| ORF | Protein showing similar identity | Comments | Aligment |
|---|---|---|---|
| EHV-1 | |||
| >gi|M86664|herpesvirus equí 1| 346-912 | Unknown function | There is an identity of 100% between the predicted orf and the unknown protein of EHV1 of which the strain is not said, also in position 346 to 912. This fragment, however, is not described in M86664 (EHV1 strain Ab4p), where the first orf is in position 1298, very distant from our prediction. Moreover, our orfs includes a region (383 to 728) described as repetitive. As a consecuence, this orf have high probabilities to belong to a protein not yet annotated for the strain Ab4p, although is a non-identifyed protein. | See aligment |
| >gi|M86664|herpesvirus equí 1| 113956-116160 >gi|M86664|herpesvirus equí 1|complem 149202-146998 | Probable antigen nuclear | There is a high homology, with very conserved fragments, between aminoacid 49 to 571 of the predicted orf (one in the normal sense and other in complementary) and aminoacid 382 to 881 and 593 to 1094 of the two protein obtained with Blast. These ones belong to two different strains of suid herpesvirus (or pseudorabia virus), member of the genus Varicellovirus, subfamily Alphaherpesvirinae (Evolutionary relatedness of Herpesvirus and their Subfamilies), identifyed as probable nuclear antigen and hypotethical protein respectively. Moreover, although the two suid herpesvirus proteins are different, the compared fragments are identical, so we can assume that form a common domain in the two proteins, shared with EHV1. So far, that orf could correspond also to a nuclear antigen for EHV1. | See aligment |
| >gi|M86664|herpesvirus equí 1| 121246-121944 >gi|M86664|herpesvirus equí 1|complem 141912-141214 | IR4 protein | Fragment 15 to 40 and subfragment 22 to 40 of the predicted orfs, show a high homology with fragments 84 to 109 and 66 to 84 ,respectively, of the protein IR4 of EHV1 strain Kentucky A. If we analise the alignment we can see that the aligned fragment is longer, but after that positions it seems due to random aminoacidic coincidence. As a consecuence, we can say that the aligned fragments may correspond to the same proteic domain present once in EHV1 strain Ab4p and twice in EHV1 strain Kentucky A. | See alignment 1(with positions 84 to 109 of strain Kentucky A) See alignment 2(with positions 66 to 84 of strain Kentucky A) |
| >gi|M86664|herpesvirus equí 1| 141933-142316 >gi|M86664|herpesvirus equí 1|complem 121225-120842 | Tegument protein | Fragment 2 to 40 of the predicted orf shares 5 repetitions of the aminoacidic sequence RPPT with 10 repetitions in the cercopitecine herpesvirus 1 (CHV1), member of the genus Simplexvirus, subfamily Alphaherpesvirinae (Evolutionary relatedness of Herpesvirus and their Subfamilies). This fragment belongs to the nucleous of the repeated sequence DHRPPTT and AGPRPPRP respectively. Aminoacids RPPT might then belong to an important domain for the function of the protein, conserved as a consecuence within the two genomes. However, it may also be due to random repetitions.Further investigation is needed to accept or discard this alignment as significative or not. | See alignment 1(with positions 507 to 545 of EHV1 -identical for positions 521 to 559, 514 to 552 and 528 to 560 of EHV1-) See alignment 2(with positions 502 to 538 of EHV1) |
| >gi|M86664|herpesvirus equí 1|complem 58188-57514 | Protein related to a DNA | There is a high homology within aminoacid 1 to 160 of the predicted orf and aminoacid 391 to 547 of a protein annoted as specific orf (afterwards identifyed as a DNA binding protein) of simplex human herpesvirus 2, member of the genus Simplexvirus, subfamily Alphaherpesvirinae (Evolutionary relatedness of Herpesvirus and their Subfamilies). We can think that this fragment belongs to a common domain between the two proteins. Furthemore, our orf may also be a DNA binding protein. | See aligment |
| EHV-4 | |||
| >gi|AF030027|herpesvirus equí 4| 12168-12482 | Tegument protein/B4 protein | There is an identity of 100% whitin aminoacid 1 to 63 of the predicted orf and aminoacid 1 to 63 of a tegument protein of EHV4 strain 1942. As a consecuence, this orf have high probabilities be a tegument protein not yet annotated for strain NS80507 | See aligment |
