Command line: [exonerate -m p2g --showtargetgff -q sars2_hs.aa.fa.canviat -t genomesars2_JXSJ01000068.1.fa] Hostname: [ws101182u] C4 Alignment: ------------ Query: SPP00002939_2.0 # Protein # seryl-tRNA synthetase 2, mitochondrial (SARS2) # Human Target: JXSJ01000068.1:subseq(306430,105116) Miichthys miiuy scaffold68, whole genome shotgun sequence Model: protein2genome:local Raw score: 1327 Query range: 40 -> 512 Target range: 49999 -> 57113 41 : ArgAsnLeuLeuTyrGluTyrAlaArgGluGlyTyrSerAlaLeuProGlnLeuAspIle : 60 |||!:! !|||||||||:!!!.!|||||||||||||||! ! !|||:!!||||||::: ArgSerSerLeuTyrGluHisValArgGluGlyTyrSerAspLysProGluLeuAspMet 50000 : CGGAGCAGTTTGTACGAACATGTCCGCGAAGGTTACAGCGACAAACCCGAGCTGGACatg : 50057 61 : GluArgPheCysAlaCysProGluGluAlaAlaHisAlaLeuGluLeuArgLysGlyGlu : 80 ... ||| !!!!::!!!.! ! !:!!||| !|||||||||!!: ArgGlyValCysGluGluThrAspLysValIleAlaAsnValGluAsnArgLysGlyAsp 50058 : agaggagtgtgtgaggaGACCGACAAAGTCATAGCGAATGTGGAGAACAGGAAGGGCGAC : 50117 81 : Leu >>>> Target Intron 1 >>>> ArgSerAlaAspLeuProAlaIleIleS : 91 ||| 1201 bp !!.! !||| ! !|||:!! !| Leu-- ++AlaLysAsnAspLysLysAlaLeuAlaS 50118 : CTGcg.........................agGCCAAGAATGACAAGAAAGCCCTCGCCA : 51351 92 : erThrTrpGlnGluLeuArgGlnLeuGlnGluGlnIleArgSerLeuGluGluGluLysA : 111 ||..! ! ..! ||| !|||!!!||| ! !! !! !||| !.!.:!!...! erValSerSerIleLeuAlaGlnPheGlnLeuPheAsnThrLeuLeuLeuAsnGlnSerV 51352 : GTGTAAGTTCAATTTTGGCACAATTTCAGCTCTTTAACACTTTGTTATTGAATCAGTCTG : 51411 112 : laAlaValThrGluAlaValArgAlaLeuLeuAlaAsnGlnAspSerGlyGluValGlnG : 131 .! !! ! !..!:!!|||! ! !! !:!! !:!!|||..!! ! ! :!! ! alMetGluHisArgSerValIleAsnGlnIleLeuAspGlnSerLeuLeuPheIleThr* 51412 : TCATGGAGCACCGATCAGTGATAAATCAGATTTTGGACCAGTCCTTGTTGTTTATCACGT : 51471 132 : lnAspProLysTyrGlnGlyLeuArgAlaArgGlyArgGluIleArgLysGluLeuValH : 151 !! !|||:!!||| ! ! ! !!:!|||||||||||||||!!...!||| !! **LeuProGluTyrThrGlnAlaValGlnLysGlyArgGluIleArgAsnArgLeuAsnG 51472 : AGCTTCCAGAGTACACCCAGGCTGTGCAGAAGGGTCGAGAGATCCGCAACAGACTGAACC : 51531 152 : isLeuTyrProArgGluAlaGlnLeuGluGluGlnPheTyrLeuGlnAlaLeuLysLeuP : 171 !.|||||||||!:!|||.!!:!!|||!!::!!:!! !||| !!:!||||||!:!|||| lnLeuTyrProLysGluThrGluLeuAspGlnGluHisTyrGlyArgAlaLeuArgLeuP 51532 : AGCTGTACCCCAAAGAGACTGAGCTGGATCAGGAACACTACGGACGAGCGCTCAGACTGC : 51591 172 : roAsnGlnThrHisProAspVal >>>> Target Intron 2 >>>> ProValGl : 181 ||||| :!!|||||||||||| 121 bp |||||||| roAsnThrSerHisProAspVal++ ++ProValGl 51592 : CCAACACCTCACACCCTGATGTGgt.........................agccAGTTGG : 51742 182 : yAspGluSerGlnAlaArgValLeuHisMetValGlyAspLysPro{V} >>>> Targ : 197 ||||||||||||||||||||||:!!.!.:!!||||||.!.||||||{!} yAspGluSerGlnAlaArgValValGluLeuValGlyGlnLysPro{G}++ 51743 : AGATGAGAGCCAGGCGAGGGTGGTGGAGCTGGTTGGACAGAAACCA{G}gt......... : 51793 198 : et Intron 3 >>>> {al}PheSerPheGlnProArgGlyHisLeuGluIleGlyGl : 210 84 bp { !}|||..!|||:!!||||||||||||:!!|||:!:||||| ++{lu}PheAspPheLysProArgGlyHisValGluLeuGlyGl 51794 : ................ag{AG}TTTGACTTCAAGCCCAGGGGTCATGTAGAGCTGGGGGA : 51913 211 : uLysLeuAspIleIleArgGln{Ly} >>>> Target Intron 4 >>>> {s}Ar : 219 |:!!|||! !:!!|||||||||{!:} 237 bp {!}!. uGluLeuGlyLeuIleArgGln{Ar}++ ++{g}Hi 51914 : GGAGTTGGGTCTCATCAGACAA{AG}gt.........................ag{A}CA : 52177 220 : gLeuSerHisValSerGlyHisArgSerTyrTyrLeuArgGlyAlaGlyAlaLeuLeuGl : 239 !|||:!!||||||||||||||||||||||||||||||||||||.!!|||||| !||||| sLeuAlaHisValSerGlyHisArgSerTyrTyrLeuArgGlyThrGlyAlaArgLeuGl 52178 : TCTGGCTCATGTCTCAGGCCACAGGTCGTACTATCTGAGGGGAACAGGGGCCAGACTTCA : 52237 240 : nHisGlyLeuValAsnPheThrPheAsnLysLeuLeuArgArg >>>> Target Int : 254 | !!.!||| !||||||.!!.!!:!!! !|||! !|||||| 97 bp nThrAlaLeuGlnAsnPheAlaLeuAspThrLeuGlnArgArg++ 52238 : GACTGCACTCCAAAACTTTGCCCTTGACACGCTGCAGCGACGGgt............... : 52284 255 : ron 5 >>>> GlyPheThrProMetThrValProAspLeuLeuArgGlyAlaValPhe : 269 ||||||! !||||||..!|||||||||:!!|||!:!|||||||||||| ++GlyPheIleProMetValValProAspMetLeuLysGlyAlaValPhe 52285 : ..........agGGCTTCATTCCCATGGTTGTACCTGACATGCTGAAGGGGGCAGTATTT : 52424 270 : >>>> Target Intron 6 >>>> GluGlyCysGlyMetThrProAsnAlaAsnP : 280 185 bp ||||||||||||||| !|||||||||:!!! ++ ++GluGlyCysGlyMetGlnProAsnAlaHisA 52425 : gt.........................agGAGGGTTGTGGGATGCAGCCCAACGCCCATC : 52642 281 : roSerGlnIleTyrAsnIleAspProAlaArgPheLysAspLeuAsnLeuAlaGlyThrA : 300 !||||||:!!|||::::!:||||||||||||||| !|||||||||||||||||||||! rgSerGlnValTyrSerLeuAspProAlaArgPheProAspLeuAsnLeuAlaGlyThrG 52643 : GTTCTCAAGTTTATTCACTGGACCCGGCACGTTTCCCGGACCTCAACCTGGCTGGAACTG : 52702 301 : laGluValGlyLeuAla{G} >>>> Target Intron 7 >>>> {ly}TyrPheM : 309 .!|||||||||:!!|||{|} 893 bp {||}||||||| lyGluValGlyValAla{G}++ ++{ly}TyrPheM 52703 : GAGAGGTCGGGGTGGCa{g}gt.........................ag{GT}TATTTCA : 53622 310 : etAspHisThrValAlaPheArgAspLeuProVal{Ar} >>>> Target Intron : 321 ||||||||.!!||| !!::!:!||||||||||||{||} 82 bp etAspHisAlaValAsnTrpLysAspLeuProVal{Ar}++ 53623 : TGGATCATGCAGTAAACTGGAAGGATCTGCCTGTC{AG}gt................... : 53662 322 : 8 >>>> {g}MetValCysSerSerThrCysTyrArgAlaGluThrAsnThrGlyGlnG : 338 {|}! !|||||||||||||||||||||||||||||||||:!!||||||::!| ++{g}ThrValCysSerSerThrCysTyrArgAlaGluThrAspThrGlyArgG 53663 : ......ag{G}ACGGTGTGCAGCAGCACCTGCTACAGAGCAGAGACGGACACGGGCAGAG : 53791 339 : luProArgGlyLeuTyrArgValHisHisPheThrLys >>>> Target Intron 9 : 351 || !! !!||||||||||||||||||||||||!.!||| 270 bp luThrTrpGlyLeuTyrArgValHisHisPheAsnLys++ 53792 : AGACGTGGGGGCTGTACAGAGTCCATCACTTCAACAAGgt.................... : 53832 352 : >>>> ValGluMetPheGlyValThrGlyProGlyLeu<->GluGlnSerSerGlnLe : 367 ::!||||||||||||||||||!.! ...:::||||||||||| ++IleGluMetPheGlyValThrAlaAspGluThrGlyArgGluSerSerGlnLe 53833 : .....agatAGAGATGTTTGGAGTGACAGCAgatgagacaggaagagagagctCTCAGCT : 54151 368 : uLeuGluGluPheLeuSerLeuGlnMetGluIleLeuThrGluLeuGlyLeuHisPhe{A : 387 |||||||||||||:!!|||||||||! |||!!:!!!:!!! !|||! !||||||!:!{| uLeuGluGluPheValSerLeuGlnLysGluMetPheSerAlaLeuGluLeuHisTyr{A 54152 : GCTGGAGGAGTTTGTCTCTTTGCAGAAAGAGATGTTTTCTGCACTGGAACTACACTAC{A : 54211 388 : r} >>>> Target Intron 10 >>>> {g}ValLeuAspMetProThrGlnGluL : 396 |} 76 bp {|}||||||||||||||||||||||||| r}++ ++{g}ValLeuAspMetProThrGlnGluL 54212 : g}gt..........................ag{A}GTGCTGGACATGCCGACACAGGAGC : 54314 397 : euGlyLeuProAlaTyrArgLysPheAspIleGluAlaTrpMetProGlyArgGlyArgP : 416 |||||! !||||||:!!||||||!:!|||||||||||||||||||||||||||..! !!! euGlyProProAlaHisArgLysTyrAspIleGluAlaTrpMetProGlyArgAsnGlyT 54315 : TGGGCCCTCCAGCACACAGGAAGTACGACATTGAAGCGTGGATGCCTGGGAGGAACGGTT : 54374 417 : heGlyGlu >>>> Target Intron 11 >>>> ValThrSerAlaSerAsnCysT : 426 :!|||||| 638 bp :!!:!!|||!.!|||||||||| yrGlyGlu++ ++IleSerSerGlySerAsnCysT 54375 : ACGGAGAGgt..........................agATTTCCAGTGGGTCCAATTGTA : 55042 427 : hrAspPheGlnSerArgArgLeuHisIleMetPheGlnThrGluAlaGlyGluLeuGlnP : 446 |||||!:!|||||||||||||||:!!|||:!!!:!:!!! !|||! !|||...||||||! hrAspTyrGlnSerArgArgLeuAsnIleLeuTyrGluArgGluAspGlySerLeuGlnT 55043 : CAGACTACCAGAGCCGACGTCTCAACATCCTGTATGAGAGAGAGGATGGCAGCCTGCAGT : 55102 447 : heAlaHisThr >>>> Target Intron 12 >>>> ValAsnAlaThrAlaCysA : 456 :!||||||||| 97 bp ||||||||||||||||||| yrAlaHisThr++ ++ValAsnAlaThrAlaCysA 55103 : ACGCCCACACAgt..........................aggTGAATGCTACAGCGTGTG : 55229 457 : laValProArgLeuLeuIleAlaLeuLeuGluSerAsnGlnGlnLys >>>> Target : 472 ||:!!|||||| !:!!||||||:!!||||||::::::||| ||| 1 laIleProArgThrIleIleAlaIleLeuGluThrHisGlnThrLys++ 55230 : CCATCCCCCGAACCATCATCGCTATCCTTgagactcatcagaccaaagt........... : 55279 473 : Intron 13 >>>> AspGlySerValLeuValProProAlaLeuGlnSerTyrLeuG : 486 714 bp !!:|||!!!|||! !||||||! !||||||||| !!||||||| ++GluGlyThrValArgValProArgAlaLeuGlnProTyrLeuG 55280 : ...............agGAGGGAACAGTACGCGTCCCACGAGCACTGCAGCCTTATCTGG : 57033 487 : lyThrAspArgIleThrAlaProThrHisValProLeuGlnTyrIleGlyProAsnGlnP : 506 || !!!: !||| ! !|||! !:!!..!||||||:!!||||||||||||||||||| lyLeuGluValIleGluLysProLysTyrThrProLeuLysTyrIleGlyProAsnGlnP 57034 : GTCTAGAAGTGATCGAAAAGCCAAAGTACACTCCACTGAAATATATCGGACCCAACCAGC : 57093 507 : roArgLysProGlyLeuPro : 512 ||!.!::!||| ! !||| roAsnArgProProArgPro 57094 : CCAATCGACCGCCCAGACCT : 57113 vulgar: SPP00002939_2.0 40 512 . JXSJ01000068.1:subseq(306430,105116) 49999 57113 + 1327 M 41 123 5 0 2 I 0 1197 3 0 2 M 97 291 5 0 2 I 0 117 3 0 2 M 18 54 S 0 1 5 0 2 I 0 80 3 0 2 S 1 2 M 20 60 S 0 2 5 0 2 I 0 233 3 0 2 S 1 1 M 35 105 5 0 2 I 0 93 3 0 2 M 16 48 5 0 2 I 0 181 3 0 2 M 36 108 S 0 1 5 0 2 I 0 889 3 0 2 S 1 2 M 14 42 S 0 2 5 0 2 I 0 78 3 0 2 S 1 1 M 29 87 5 0 2 I 0 266 3 0 2 M 11 33 G 0 3 M 25 75 S 0 2 5 0 2 I 0 72 3 0 2 S 1 1 M 31 93 5 0 2 I 0 634 3 0 2 M 31 93 5 0 2 I 0 93 3 0 2 M 22 66 5 0 2 I 0 1710 3 0 2 M 41 123 # --- START OF GFF DUMP --- # # ##gff-version 2 ##source-version exonerate:protein2genome:local 2.2.0 ##date 2016-11-29 ##type DNA # # # seqname source feature start end score strand frame attributes # JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local gene 50000 57113 1327 + . gene_id 1 ; sequence SPP00002939_2.0 ; gene_orientation + JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 50000 50122 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 50000 50122 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 50123 50124 . + . intron_id 1 ; splice_site "CG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 50123 51323 . + . intron_id 1 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 51322 51323 . + . intron_id 0 ; splice_site "AG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 51324 51614 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 51324 51614 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 51615 51616 . + . intron_id 2 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 51615 51735 . + . intron_id 2 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 51734 51735 . + . intron_id 1 ; splice_site "ag" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 51736 51790 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 51736 51790 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 51791 51792 . + . intron_id 3 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 51791 51874 . + . intron_id 3 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 51873 51874 . + . intron_id 2 ; splice_site "ag" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 51875 51938 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 51875 51938 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 51939 51940 . + . intron_id 4 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 51939 52175 . + . intron_id 4 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 52174 52175 . + . intron_id 3 ; splice_site "AG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 52176 52281 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 52176 52281 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 52282 52283 . + . intron_id 5 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 52282 52378 . + . intron_id 5 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 52377 52378 . + . intron_id 4 ; splice_site "AG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 52379 52426 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 52379 52426 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 52427 52428 . + . intron_id 6 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 52427 52611 . + . intron_id 6 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 52610 52611 . + . intron_id 5 ; splice_site "AG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 52612 52720 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 52612 52720 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 52721 52722 . + . intron_id 7 ; splice_site "gt" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 52721 53613 . + . intron_id 7 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 53612 53613 . + . intron_id 6 ; splice_site "AG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 53614 53659 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 53614 53659 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 53660 53661 . + . intron_id 8 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 53660 53741 . + . intron_id 8 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 53740 53741 . + . intron_id 7 ; splice_site "AG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 53742 53829 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 53742 53829 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 53830 53831 . + . intron_id 9 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 53830 54099 . + . intron_id 9 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 54098 54099 . + . intron_id 8 ; splice_site "ag" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 54100 54212 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 54100 54212 . + . insertions 3 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 54213 54214 . + . intron_id 10 ; splice_site "gt" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 54213 54288 . + . intron_id 10 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 54287 54288 . + . intron_id 9 ; splice_site "aG" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 54289 54382 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 54289 54382 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 54383 54384 . + . intron_id 11 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 54383 55020 . + . intron_id 11 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 55019 55020 . + . intron_id 10 ; splice_site "ag" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 55021 55113 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 55021 55113 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 55114 55115 . + . intron_id 12 ; splice_site "GT" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 55114 55210 . + . intron_id 12 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 55209 55210 . + . intron_id 11 ; splice_site "ag" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 55211 55276 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 55211 55276 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice5 55277 55278 . + . intron_id 13 ; splice_site "gt" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local intron 55277 56990 . + . intron_id 13 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local splice3 56989 56990 . + . intron_id 12 ; splice_site "ag" JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local cds 56991 57113 . + . JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local exon 56991 57113 . + . insertions 0 ; deletions 0 JXSJ01000068.1:subseq(306430,105116) exonerate:protein2genome:local similarity 50000 57113 1327 + . alignment_id 1 ; Query SPP00002939_2.0 ; Align 50000 41 123 ; Align 51324 82 291 ; Align 51736 179 54 ; Align 51877 198 60 ; Align 52177 219 105 ; Align 52379 254 48 ; Align 52612 270 108 ; Align 53616 307 42 ; Align 53743 322 87 ; Align 54100 351 33 ; Align 54136 362 75 ; Align 54290 388 93 ; Align 55021 419 93 ; Align 55211 450 66 ; Align 56991 472 123 # --- END OF GFF DUMP --- # -- completed exonerate analysis