BLASTP 2.2.26 [Sep-21-2011] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|344164181|gb|JH000884.1|:subseq(579901,2794) Cricetulus griseus cell line CHO-K1 unplaced genomic scaffold scaffold913, whole genome shotgun sequence:[translate(1)] (277 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects 21,473,622 sequences; -1,227,654,391 total letters Searching... please wait.. done Score E Sequences producing significant alignments: (bits) Value ref|NP_001243713.1| type III iodothyronine deiodinase [Cricetulu... 572 0.0 sp|P49897|IOD3_RAT RecName: Full=Type III iodothyronine deiodina... 560 0.0 ref|NP_058906.3| type III iodothyronine deiodinase [Rattus norve... 560 0.0 sp|Q91ZI8|IOD3_MOUSE RecName: Full=Type III iodothyronine deiodi... 558 0.0 ref|NP_742117.2| type III iodothyronine deiodinase [Mus musculus] 558 0.0 ref|XP_003919601.1| PREDICTED: type III iodothyronine deiodinase... 541 0.0 ref|NP_001116121.2| type III iodothyronine deiodinase [Macaca mu... 541 0.0 sp|P55073|IOD3_HUMAN RecName: Full=Type III iodothyronine deiodi... 539 0.0 ref|XP_003846113.1| PREDICTED: type III iodothyronine deiodinase... 539 0.0 ref|NP_001353.4| type III iodothyronine deiodinase [Homo sapiens] 539 0.0 gb|AAB35616.2| type 3 iodothyronine deiodinase [Homo sapiens] 537 0.0 ref|XP_003734125.1| PREDICTED: LOW QUALITY PROTEIN: type III iod... 537 0.0 ref|XP_003780591.1| PREDICTED: type III iodothyronine deiodinase... 537 0.0 gb|EGV99748.1| Type III iodothyronine deiodinase [Cricetulus gri... 522 0.0 ref|NP_001116122.1| type III iodothyronine deiodinase [Ovis arie... 521 0.0 sp|Q5I3B1|IOD3_BOVIN RecName: Full=Type III iodothyronine deiodi... 519 0.0 ref|NP_001010993.2| type III iodothyronine deiodinase [Bos taurus] 519 0.0 ref|NP_001157660.1| type III iodothyronine deiodinase [Canis lup... 518 0.0 ref|NP_001001625.2| type III iodothyronine deiodinase [Sus scrofa] 518 0.0 ref|XP_002926780.1| PREDICTED: LOW QUALITY PROTEIN: type III iod... 517 0.0 sp|Q6QN11|IOD3_PIG RecName: Full=Type III iodothyronine deiodina... 516 0.0 ref|XP_004001503.1| PREDICTED: type III iodothyronine deiodinase... 511 e-180 gb|ACX42083.1| type III iodothyronine deiodinase, partial [Crice... 486 e-172 ref|XP_001917251.1| PREDICTED: LOW QUALITY PROTEIN: type III iod... 442 e-155 ref|XP_002721754.1| PREDICTED: deiodinase, iodothyronine, type I... 414 e-143 ref|XP_003314554.1| PREDICTED: LOW QUALITY PROTEIN: type III iod... 402 e-139 ref|NP_001116120.1| type III iodothyronine deiodinase [Gallus ga... 348 e-117 gb|ACH42530.1| deiodinase iodothyronine type III [Ornithorhynchu... 348 e-117 ref|XP_003756592.1| PREDICTED: type III iodothyronine deiodinase... 342 e-114 gb|ACH42531.1| deiodinase iodothyronine type III [Macropus eugenii] 341 e-113 sp|O42412|IOD3_CHICK RecName: Full=Type III iodothyronine deiodi... 338 e-113 emb|CAA72136.1| type III iodothyronine deiodinase [Gallus gallus] 338 e-113 gb|ACZ59442.1| hepatic iodothyronine deiodinase type III [Pituop... 338 e-113 gb|AEO36972.1| deiodinase 3 [Microtus arvalis] 330 e-111 gb|ABX60542.1| iodothyronine deiodinase type 3 [Chiloscyllium pu... 332 e-111 ref|NP_001107139.2| deiodinase, iodothyronine, type III [Xenopus... 328 e-109 ref|NP_001081332.1| type III iodothyronine deiodinase [Xenopus l... 324 e-107 sp|P49898|IOD3_RANCA RecName: Full=Type III iodothyronine deiodi... 315 e-104 gb|ACF47589.1| deiodinase iodothyronine type III [Peromyscus pol... 307 e-103 gb|AAR05175.1| deiodinase type III [Neoceratodus forsteri] 311 e-102 emb|CAP16956.1| putative thyroxine 5-deiodinase [Solea senegalen... 302 3e-99 emb|CAA71997.1| Type III iodothyronine deiodinase [Oreochromis n... 302 4e-99 gb|ABP64747.1| deiodinase type 3 [Carassius auratus] 301 9e-99 gb|EDL18680.1| deiodinase, iodothyronine type III [Mus musculus]... 295 3e-98 sp|A7YD35|IOD3_SPAAU RecName: Full=Type III iodothyronine deiodi... 298 8e-98 dbj|BAG15908.1| iodothyronine deiodinase type III [Paralichthys ... 298 1e-97 ref|NP_001129619.1| type III iodothyronine deiodinase b [Takifug... 295 1e-96 gb|ADD82415.1| iodothyronine deiodinase type 3 [Chrysiptera cyanea] 295 1e-96 gb|ADC92287.1| type III iodothyronine deiodinase [Siganus guttatus] 295 2e-96 ref|NP_001129618.1| type III iodothyronine deiodinase a [Takifug... 291 4e-95 ref|NP_001171406.2| type III iodothyronine deiodinase [Danio rerio] 291 5e-95 gb|ADD38971.1| deiodinase 3 [Danio rerio] 288 1e-93 ref|NP_001242932.1| type III iodothyronine deiodinase-like [Dani... 283 1e-91 gb|EHH28178.1| hypothetical protein EGK_18555 [Macaca mulatta] 278 2e-91 gb|EAW81747.1| deiodinase, iodothyronine, type III [Homo sapiens] 276 5e-91 ref|XP_003941651.1| PREDICTED: type III iodothyronine deiodinase... 277 6e-91 emb|CAD61926.1| unnamed protein product [Homo sapiens] 276 1e-90 dbj|BAF84999.1| unnamed protein product [Homo sapiens] 275 2e-90 gb|ADC92286.2| type III iodothyronine deiodinase [Halichoeres tr... 265 8e-85 gb|AER97245.1| Type III iodothyronine deiodinase [Mustela putori... 258 5e-84 gb|AEK78061.1| iodothyronine deiodinase type 3 [Scarus taeniopte... 249 1e-79 gb|ADC80775.1| iodothyronine deiodinase type III, partial [Gobio... 244 2e-77 emb|CAG01826.1| unnamed protein product [Tetraodon nigroviridis] 236 2e-74 gb|AFD01668.1| iodothyronine deiodinase type III, partial [Parus... 235 3e-74 gb|ABN54803.1| iodothyronine deiodinase type III [Sander vitreus] 206 6e-63 gb|ADI86261.1| iodothyronine deiodinase type 3 [Scarus iseri] 196 4e-59 gb|ACJ03410.1| type III iodothyronine deiodinase [Phodopus sungo... 178 2e-53 gb|AEH68217.1| type III iodothyronine deiodinase, partial [Engys... 178 1e-52 gb|AAI06401.1| Dio3 protein [Xenopus laevis] 177 3e-52 ref|NP_001087559.1| MGC84484 protein [Xenopus laevis] >gi|512588... 174 4e-51 gb|AAI57249.1| dio3 protein [Xenopus (Silurana) tropicalis] 174 5e-51 sp|O42449|IOD1_ORENI RecName: Full=Type I iodothyronine deiodina... 162 5e-45 ref|XP_003439849.1| PREDICTED: LOW QUALITY PROTEIN: type I iodot... 162 5e-45 sp|P49896|IOD2_RANCA RecName: Full=Type II iodothyronine deiodin... 162 5e-45 sp|O42411|IOD1_CHICK RecName: Full=Type I iodothyronine deiodina... 161 8e-45 emb|CAA71996.1| Type I iodothyronine deiodinase [Gallus gallus] 161 8e-45 ref|NP_001091083.1| type I iodothyronine deiodinase [Gallus gallus] 161 9e-45 ref|XP_003793192.1| PREDICTED: type I iodothyronine deiodinase [... 160 4e-44 gb|ACB59241.1| type 2 iodothyronine 5'-deiodinase [Coturnix japo... 160 4e-44 ref|NP_067685.5| type I iodothyronine deiodinase [Rattus norvegi... 160 4e-44 emb|CAA41063.1| thyroxine deiodinase [Rattus norvegicus] 160 4e-44 gb|AAK40121.1| type II deodinase [Xenopus laevis] 160 5e-44 gb|ABI93489.1| iodothyronine deiodinase type III [Hippoglossus h... 155 7e-44 sp|Q9IAX2|IOD2_CHICK RecName: Full=Type II iodothyronine deiodin... 159 1e-43 ref|NP_001243688.1| type I iodothyronine deiodinase [Cricetulus ... 159 1e-43 sp|Q61153|IOD1_MOUSE RecName: Full=Type I iodothyronine deiodina... 159 1e-43 gb|AAH19786.1| Deiodinase, iodothyronine, type I [Mus musculus] 159 1e-43 ref|NP_031886.3| type I iodothyronine deiodinase [Mus musculus] ... 159 1e-43 ref|XP_003208923.1| PREDICTED: LOW QUALITY PROTEIN: type I iodot... 158 1e-43 ref|NP_989445.2| type II iodothyronine deiodinase [Gallus gallus] 159 2e-43 sp|Q804E1|IOD1_FUNHE RecName: Full=Type I iodothyronine deiodina... 157 4e-43 gb|ABI93488.1| iodothyronine deiodinase type I [Hippoglossus hip... 155 5e-43 ref|NP_001007127.1| type I iodothyronine deiodinase [Canis lupus... 157 5e-43 ref|XP_003206693.1| PREDICTED: LOW QUALITY PROTEIN: type II iodo... 157 6e-43 ref|NP_001116124.1| type I iodothyronine deiodinase [Macaca mula... 156 8e-43 dbj|BAG15906.1| iodothyronine deiodinase type I [Paralichthys ol... 156 1e-42 ref|NP_001159924.1| deiodinase, iodothyronine, type I [Equus cab... 155 1e-42 ref|NP_001257898.1| deiodinase, iodothyronine, type II [Taeniopy... 156 2e-42 ref|NP_997954.2| type II iodothyronine deiodinase [Danio rerio] ... 155 2e-42 ref|XP_003411116.1| PREDICTED: LOW QUALITY PROTEIN: type I iodot... 155 2e-42 prf||1705292A iodothyronine deiodinase I 155 3e-42 ref|XP_003214410.1| PREDICTED: LOW QUALITY PROTEIN: type II iodo... 155 3e-42 ref|XP_002915789.1| PREDICTED: LOW QUALITY PROTEIN: type I iodot... 154 5e-42 ref|XP_003220351.1| PREDICTED: LOW QUALITY PROTEIN: type I iodot... 154 5e-42 ref|NP_001116065.1| type I iodothyronine deiodinase [Bos taurus]... 154 6e-42 ref|XP_001634053.1| predicted protein [Nematostella vectensis] >... 152 9e-42 sp|Q8UVX8|IOD2_NEOFS RecName: Full=Type II iodothyronine deiodin... 154 1e-41 emb|CAF02303.1| putative iodothyronine deiodinase type 1 [Sparus... 153 2e-41 ref|NP_001009267.1| type I iodothyronine deiodinase [Felis catus... 152 2e-41 ref|NP_001184161.2| type II iodothyronine deiodinase [Xenopus (S... 153 2e-41 gb|AFE86483.1| type I iodothyronine deiodinase [Bubalus bubalis] 152 2e-41 ref|NP_000783.2| type I iodothyronine deiodinase isoform a [Homo... 152 2e-41 ref|NP_001001627.1| type I iodothyronine deiodinase [Sus scrofa]... 152 2e-41 ref|NP_001243226.1| deiodinase, iodothyronine, type 1 [Xenopus (... 152 2e-41 ref|NP_001243691.1| type II iodothyronine deiodinase [Cricetulus... 152 3e-41 ref|NP_034180.1| type II iodothyronine deiodinase [Mus musculus]... 152 3e-41 ref|NP_001089136.1| type I iodothyronine deiodinase [Xenopus lae... 152 5e-41 ref|NP_113908.3| type II iodothyronine deiodinase [Rattus norveg... 152 5e-41 gb|AEO36971.1| deiodinase 2 [Microtus arvalis] 152 5e-41 ref|NP_001129993.1| iodothyronine deiodinase type II [Oryzias la... 152 6e-41 gb|AFP99133.1| deiodinase 1 [Sebastiscus marmoratus] 151 9e-41 ref|XP_002750893.2| PREDICTED: LOW QUALITY PROTEIN: type I iodot... 151 9e-41 ref|NP_001116123.1| type I iodothyronine deiodinase [Pan troglod... 150 1e-40 dbj|BAA25186.1| type II iodothyronine deiodinase [Rattus rattus] 151 1e-40 ref|NP_001244906.1| type II iodothyronine deiodinase [Cavia porc... 151 1e-40 sp|Q95N00|IOD1_SUNMU RecName: Full=Type I iodothyronine deiodina... 150 1e-40 ref|NP_001093428.1| type I iodothyronine deiodinase [Oryctolagus... 150 2e-40 ref|XP_003339533.1| PREDICTED: LOW QUALITY PROTEIN: type II iodo... 150 3e-40 ref|NP_001244903.1| type I iodothyronine deiodinase [Cavia porce... 149 3e-40 ref|NP_001243229.1| deiodinase, iodothyronine, type II [Oryctola... 150 4e-40 dbj|BAG15907.1| iodothyronine deiodinase type II [Paralichthys o... 150 4e-40 ref|NP_001159927.1| type II iodothyronine deiodinase [Equus caba... 149 5e-40 gb|ADB46158.1| type II iodothyronine deiodinase [Siganus guttatus] 149 6e-40 ref|NP_001116110.1| type II iodothyronine deiodinase isoform 2 [... 149 8e-40 gb|ABO21650.1| iodothyronine type II deiodinase [Oryctolagus cun... 149 9e-40 ref|NP_001117740.1| type II iodothyronine deiodinase [Oncorhynch... 149 1e-39 ref|XP_002590630.1| hypothetical protein BRAFLDRAFT_123596 [Bran... 152 1e-39 ref|XP_003756244.1| PREDICTED: type II iodothyronine deiodinase ... 148 1e-39 ref|NP_054644.1| type II iodothyronine deiodinase isoform a [Hom... 148 2e-39 ref|NP_001001626.1| type II iodothyronine deiodinase [Sus scrofa... 148 2e-39 gb|AAC95470.1| type 2 iodothyronine deiodinase [Homo sapiens] 148 2e-39 sp|Q6QN12|IOD2_PIG RecName: Full=Type II iodothyronine deiodinas... 148 2e-39 ref|NP_001116117.1| type II iodothyronine deiodinase [Canis lupu... 148 2e-39 ref|NP_001010992.1| type II iodothyronine deiodinase [Bos taurus... 148 2e-39 gb|ACX31206.1| deiodinase 2 [Ovis aries] 147 2e-39 gb|AAB39651.2| type II iodothyronine deiodinase [Fundulus hetero... 147 4e-39 sp|P79747|IOD2_FUNHE RecName: Full=Type II iodothyronine deiodin... 147 4e-39 ref|XP_002919093.1| PREDICTED: LOW QUALITY PROTEIN: type II iodo... 147 4e-39 ref|NP_001129616.1| iodothyronine deiodinase type I [Takifugu ru... 146 5e-39 gb|ACX31205.1| deiodinase 1 [Ovis aries] 143 7e-39 ref|NP_001007284.2| type I iodothyronine deiodinase [Danio rerio... 146 8e-39 gb|ADD82413.1| iodothyronine deiodinase type 2 [Chrysiptera cyanea] 146 8e-39 ref|XP_001628745.1| predicted protein [Nematostella vectensis] >... 143 2e-38 ref|NP_001129617.1| iodothyronine deiodinase type II [Takifugu r... 145 2e-38 ref|XP_003770386.1| PREDICTED: type I iodothyronine deiodinase [... 146 3e-38 gb|ACX31203.1| deiodinase 2, partial [Cricetus cricetus] 144 3e-38 gb|ABM47422.1| iodothyronine type II deiodinase [Xenopus (Silura... 141 1e-37 gb|AAR25890.1| iodothyronine deiodinase [Halocynthia roretzi] 142 2e-37 gb|ADD82414.1| iodothyronine deiodinase type 1 [Chrysiptera cyanea] 142 2e-37 emb|CAP16957.1| putative thyroxine 5'-deiodinase [Solea senegale... 140 5e-37 ref|XP_003891983.1| PREDICTED: type I iodothyronine deiodinase [... 142 7e-37 emb|CAG10462.1| unnamed protein product [Tetraodon nigroviridis] 135 4e-36 gb|ACO57581.1| iodothyronine deiodinase type I [Gillichthys seta] 137 4e-36 gb|ACO57580.1| iodothyronine deiodinase type I [Gillichthys mira... 137 4e-36 emb|CCD22053.1| putative iodothyronine deiodinase type 2.2, part... 135 1e-35 ref|NP_998758.1| type I iodothyronine deiodinase isoform b [Homo... 135 2e-35 ref|XP_003787003.1| PREDICTED: LOW QUALITY PROTEIN: type II iodo... 138 2e-35 ref|XP_003924661.1| PREDICTED: type II iodothyronine deiodinase ... 138 3e-35 ref|XP_001641736.1| predicted protein [Nematostella vectensis] >... 134 4e-35 gb|AFR11377.1| deiodinase 2, partial [Ovis aries] 133 1e-34 emb|CAO02453.1| deiodinase iodothyronine type II [Tremarctos orn... 132 2e-34 ref|XP_003734100.1| PREDICTED: LOW QUALITY PROTEIN: type II iodo... 135 2e-34 emb|CAO02448.1| deiodinase iodothyronine type II [Ursus arctos] ... 132 2e-34 ref|NP_001116109.1| type II iodothyronine deiodinase isoform 1 [... 135 3e-34 gb|ACZ37063.1| deiodinase type III [Cyclorana alboguttata] 128 4e-34 ref|XP_003808941.1| PREDICTED: type II iodothyronine deiodinase ... 134 6e-34 ref|NP_001007024.1| type II iodothyronine deiodinase isoform b [... 134 6e-34 ref|XP_001636571.1| predicted protein [Nematostella vectensis] >... 133 7e-34 ref|XP_002825039.2| PREDICTED: type II iodothyronine deiodinase ... 134 8e-34 ref|NP_001152766.1| type II iodothyronine deiodinase [Macaca mul... 134 8e-34 ref|XP_003987942.1| PREDICTED: type II iodothyronine deiodinase ... 134 1e-33 ref|XP_003902172.1| PREDICTED: LOW QUALITY PROTEIN: type II iodo... 133 2e-33 dbj|BAB16838.1| type II iodothyronine deiodinase [Homo sapiens] 132 6e-33 gb|AAO65268.1| iodothyronine deiodinase type I Deio1 [Danio rerio] 128 3e-32 gb|ADH94050.1| type II iodothyronine deiodinase [Halichoeres tri... 126 4e-32 gb|ABY40369.1| iodothyronine deiodinase type III, partial [Caras... 124 4e-32 dbj|BAI43476.1| type II iodothyronine deiodinase [Mesocricetus a... 126 1e-31 gb|AEX08671.1| deiodinase [Chlamys farreri] 126 6e-31 emb|CAO02450.1| deiodinase iodothyronine type II [Helarctos mala... 122 9e-31 emb|CAO02447.1| deiodinase iodothyronine type II [Ursus maritimus] 122 1e-30 gb|EHH28085.1| hypothetical protein EGK_18431 [Macaca mulatta] 122 9e-30 dbj|BAE54452.1| type II iodothyronine deiodinase [Anguilla japon... 117 8e-29 gb|EHB12960.1| Type II iodothyronine deiodinase [Heterocephalus ... 116 1e-27 gb|ACX37406.1| iodothyronine deiodinase type I [Phodopus sungorus] 110 7e-27 gb|EKC42322.1| Type I iodothyronine deiodinase [Crassostrea gigas] 109 2e-26 gb|ABN54801.1| iodothyronine deiodinase type I [Sander vitreus] 108 2e-26 gb|AAQ05027.1| deiodinase 2 [Scophthalmus maximus] 108 4e-26 gb|ABD60086.1| type III iodothyronine deiodinase [Rana pipiens] 106 1e-25 gb|ABP64746.1| deiodinase type 2 [Carassius auratus] 108 2e-25 gb|EAX06720.1| deiodinase, iodothyronine, type I [Homo sapiens] ... 106 2e-25 gb|EGW05819.1| Type II iodothyronine deiodinase [Cricetulus gris... 108 5e-25 emb|CCD22052.1| putative iodothyronine deiodinase type 2.11, par... 107 8e-25 gb|ADI86260.1| iodothyronine deiodinase type 2 [Scarus iseri] 103 2e-24 gb|EAX06722.1| deiodinase, iodothyronine, type I [Homo sapiens] 104 2e-24 gb|AEK78060.1| iodothyronine deiodinase type 2 [Scarus taeniopte... 103 5e-24 gb|AEH68216.1| type II iodothyronine deiodinase, partial [Engyst... 102 6e-24 gb|AEQ37342.1| deiodinase iodothyronine type 3, partial [Rana sy... 100 2e-23 ref|XP_002585701.1| hypothetical protein BRAFLDRAFT_73773 [Branc... 102 5e-23 dbj|BAE46994.1| deiodinase iodothyronine type II [Capra hircus] 102 5e-23 ref|XP_002603395.1| hypothetical protein BRAFLDRAFT_80387 [Branc... 99 1e-22 gb|AEB16009.1| 5-deiodinase type III [Rana luteiventris] 97 3e-22 ref|XP_002602532.1| hypothetical protein BRAFLDRAFT_93837 [Branc... 96 4e-21 gb|AAO65269.1| iodothyronine deiodinase type II Deio2 [Danio rerio] 96 6e-21 ref|XP_002602534.1| hypothetical protein BRAFLDRAFT_227250 [Bran... 94 7e-21 gb|EDL81667.1| rCG20972 [Rattus norvegicus] 96 7e-21 gb|AAK15277.1| hepatic type I 5'-deiodinase [Bos taurus] 94 8e-21 ref|XP_643546.2| thyroxine 5'-deiodinase [Dictyostelium discoide... 91 1e-18 emb|CAG01446.1| unnamed protein product [Tetraodon nigroviridis] 88 8e-18 ref|XP_001619399.1| hypothetical protein NEMVEDRAFT_v1g224218 [N... 84 8e-17 gb|ABY40367.1| iodothyronine deiodinase type I, partial [Carassi... 81 2e-16 emb|CBY15603.1| unnamed protein product [Oikopleura dioica] 80 6e-16 emb|CBY11881.1| unnamed protein product [Oikopleura dioica] 80 6e-16 emb|CBY15960.1| unnamed protein product [Oikopleura dioica] 80 6e-16 ref|NP_001034805.1| type I iodothyronine deiodinase isoform d [H... 81 7e-16 gb|ABI93490.1| iodothyronine deiodinase type II [Hippoglossus hi... 79 8e-16 emb|CBY40202.1| unnamed protein product [Oikopleura dioica] 80 1e-15 gb|ABK20155.1| iodothyronine deiodinase 2 [Sparus aurata] 79 1e-15 emb|CBY06719.1| unnamed protein product [Oikopleura dioica] >gi|... 79 2e-15 gb|EAX06724.1| deiodinase, iodothyronine, type I [Homo sapiens] 76 1e-14 gb|ABP64745.1| deiodinase type 1 [Carassius auratus] 76 1e-14 gb|EHH14806.1| hypothetical protein EGK_00786 [Macaca mulatta] >... 78 2e-14 gb|ABY40368.1| iodothyronine deiodinase type II, partial [Carass... 75 3e-14 ref|XP_003815051.1| PREDICTED: type I iodothyronine deiodinase [... 77 5e-14 ref|XP_003273125.1| PREDICTED: type I iodothyronine deiodinase-l... 77 5e-14 ref|XP_002810846.1| PREDICTED: type I iodothyronine deiodinase [... 77 5e-14 ref|NP_001034804.1| type I iodothyronine deiodinase isoform c [H... 76 7e-14 ref|XP_003921585.1| PREDICTED: type I iodothyronine deiodinase [... 76 1e-13 gb|ADI86259.1| iodothyronine deiodinase type I [Scarus iseri] 72 2e-13 emb|CBY41529.1| unnamed protein product [Oikopleura dioica] >gi|... 72 5e-13 ref|XP_002611468.1| hypothetical protein BRAFLDRAFT_117208 [Bran... 77 6e-13 emb|CBY38343.1| unnamed protein product [Oikopleura dioica] 71 2e-12 gb|AEQ37341.1| deiodinase iodothyronine type 2, partial [Rana sy... 70 4e-12 gb|AFD01667.1| iodothyronine deiodinase type II, partial [Parus ... 69 1e-11 ref|XP_002740369.1| PREDICTED: deiodinase, iodothyronine, type I... 69 4e-11 gb|EGV91737.1| Type I iodothyronine deiodinase [Cricetulus griseus] 66 3e-10 gb|EHB18225.1| Type I iodothyronine deiodinase [Heterocephalus g... 65 4e-10 ref|XP_002112802.1| hypothetical protein TRIADDRAFT_56321 [Trich... 64 5e-10 ref|XP_002112745.1| hypothetical protein TRIADDRAFT_56187 [Trich... 65 6e-10 ref|XP_002114085.1| hypothetical protein TRIADDRAFT_58195 [Trich... 65 7e-10 gb|EFA74533.1| thyroxine 5'-deiodinase [Polysphondylium pallidum... 65 1e-09 gb|EKC43235.1| Type III iodothyronine deiodinase [Crassostrea gi... 62 2e-09 ref|XP_002118802.1| hypothetical protein TRIADDRAFT_34769 [Trich... 61 7e-09 ref|XP_002114084.1| hypothetical protein TRIADDRAFT_58192 [Trich... 62 7e-09 gb|AEB16011.1| iodothyronine deiodinase type II [Rana luteiventris] 59 1e-08 ref|XP_002602531.1| hypothetical protein BRAFLDRAFT_93836 [Branc... 59 3e-08 ref|XP_002738953.1| PREDICTED: deiodinase, iodothyronine, type I... 61 6e-08 ref|YP_824751.1| hypothetical protein Acid_3493 [Candidatus Soli... 60 2e-07 ref|NP_001167642.1| type I iodothyronine deiodinase-like [Saccog... 59 3e-07 ref|XP_003294566.1| hypothetical protein DICPUDRAFT_43625 [Dicty... 58 4e-07 gb|EFA74534.1| thyroxine 5'-deiodinase [Polysphondylium pallidum... 57 6e-07 ref|XP_002114412.1| hypothetical protein TRIADDRAFT_58193 [Trich... 57 6e-07 ref|XP_002735847.1| PREDICTED: hypothetical protein [Saccoglossu... 58 1e-06 ref|XP_003726828.1| PREDICTED: type I iodothyronine deiodinase-l... 55 1e-06 ref|XP_003725688.1| PREDICTED: type III iodothyronine deiodinase... 56 2e-06 ref|XP_002600517.1| hypothetical protein BRAFLDRAFT_70110 [Branc... 56 2e-06 ref|XP_002114083.1| hypothetical protein TRIADDRAFT_58190 [Trich... 55 4e-06 gb|ABN54802.1| iodothyronine deiodinase type II [Sander vitreus] 53 4e-06 gb|EKC43234.1| Type III iodothyronine deiodinase [Crassostrea gi... 52 6e-06 gb|EDL90437.1| deiodinase, iodothyronine, type I [Rattus norvegi... 53 6e-06 ref|XP_002114413.1| hypothetical protein TRIADDRAFT_58194 [Trich... 53 7e-06 ref|XP_002112307.1| hypothetical protein TRIADDRAFT_56198 [Trich... 52 3e-05 gb|AAB00228.1| type 1 deiodinase [Mus musculus] 50 7e-05 gb|AAH37080.1| Dio1 protein, partial [Mus musculus] 50 9e-05 gb|EGD76896.1| hypothetical protein PTSG_08241 [Salpingoeca sp. ... 51 2e-04 gb|EAX06721.1| deiodinase, iodothyronine, type I [Homo sapiens] ... 48 3e-04 ref|ZP_11135160.1| hypothetical protein B30_18292 [Celeribacter ... 49 5e-04 ref|YP_593856.1| alkyl hydroperoxide reductase [Candidatus Korib... 49 5e-04 ref|XP_002733917.1| PREDICTED: Type I iodothyronine deiodinase-l... 47 7e-04 ref|XP_002735986.1| PREDICTED: putative thyroxine 5-deiodinase-l... 49 0.001 ref|XP_003260875.1| PREDICTED: type II iodothyronine deiodinase-... 45 0.002 dbj|BAF84899.1| unnamed protein product [Homo sapiens] 45 0.002 gb|AAH63118.1| DIO2 protein [Homo sapiens] 45 0.002 gb|AFE76074.1| type II iodothyronine deiodinase isoform a [Macac... 45 0.003 gb|ACE74243.1| type I iodothyronine deiodinase [Gobiocypris rarus] 42 0.010 ref|ZP_02164430.1| alkyl hydroperoxide reductase/ Thiol specific... 44 0.017 ref|ZP_07758391.1| antioxidant, AhpC/TSA family [Megasphaera mic... 44 0.019 emb|CBY20015.1| unnamed protein product [Oikopleura dioica] 41 0.048 ref|XP_001430403.1| hypothetical protein [Paramecium tetraurelia... 40 0.16 gb|AEM37686.1| iodothyronine deiodinase type I [Epinephelus brun... 40 0.18 ref|YP_004493455.1| alkyl hydroperoxide reductase/ thiol specifi... 41 0.21 ref|YP_005357658.1| hypothetical protein KQS_08320 [Flavobacteri... 41 0.23 gb|AAH76008.1| Deiodinase, iodothyronine, type I [Danio rerio] 39 0.27 ref|YP_003714955.1| Thiol-disulfide isomerase/thioredoxin-like p... 39 0.78 gb|EGG15861.1| thyroxine 5'-deiodinase [Dictyostelium fasciculatum] 37 1.0 ref|YP_006416829.1| thiol-disulfide isomerase-like thioredoxin [... 38 1.9 ref|YP_517428.1| hypothetical protein DSY1195 [Desulfitobacteriu... 38 2.0 gb|EHL05645.1| antioxidant, AhpC/TSA family [Desulfitobacterium ... 37 3.6 gb|EHB56044.1| alkyl hydroperoxide reductase/ Thiol specific ant... 37 4.6 ref|ZP_11194980.1| alkyl hydroperoxide reductase/ thiol specific... 37 4.6 ref|ZP_08845605.1| redoxin domain protein [Anaerophaga thermohal... 36 6.4 ref|ZP_09669849.1| alkyl hydroperoxide reductase/ Thiol specific... 36 8.4 ref|ZP_07932774.1| redoxin protein [Anaerostipes sp. 3_2_56FAA] ... 36 8.4 ref|YP_590750.1| deiodinase, iodothyronine, type I [Candidatus K... 34 8.6 ref|ZP_11223909.1| thiol-disulfide oxidoreductase [Gillisia sp. ... 35 8.7 >ref|NP_001243713.1| type III iodothyronine deiodinase [Cricetulus griseus] Length = 304 Score = 572 bits (1474), Expect = 0.0 Identities = 276/277 (99%), Positives = 276/277 (99%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 27 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF Sbjct: 87 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQGSRPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSQRILDYAQGSRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 303 >sp|P49897|IOD3_RAT RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|AAC52241.2| type III iodiothyronine deiodinase [Rattus norvegicus] Length = 278 Score = 560 bits (1443), Expect = 0.0 Identities = 269/277 (97%), Positives = 272/277 (98%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 1 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEE+P DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+RPDGF Sbjct: 61 NSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 181 WVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHGTRPRR Sbjct: 241 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPRR 277 >ref|NP_058906.3| type III iodothyronine deiodinase [Rattus norvegicus] Length = 304 Score = 560 bits (1443), Expect = 0.0 Identities = 269/277 (97%), Positives = 272/277 (98%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEE+P DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+RPDGF Sbjct: 87 NSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHGTRPRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPRR 303 >sp|Q91ZI8|IOD3_MOUSE RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|AAL23960.1|AF426023_1 type 3 iodothyronine deiodinase [Mus musculus] dbj|BAE24483.1| unnamed protein product [Mus musculus] dbj|BAE26869.1| unnamed protein product [Mus musculus] gb|AAI06848.1| Deiodinase, iodothyronine type III [Mus musculus] gb|AAI06849.1| Deiodinase, iodothyronine type III [Mus musculus] Length = 278 Score = 558 bits (1438), Expect = 0.0 Identities = 268/277 (96%), Positives = 271/277 (97%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 1 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEE+P DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+RPDGF Sbjct: 61 NSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 181 WVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHGTRP R Sbjct: 241 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPHR 277 >ref|NP_742117.2| type III iodothyronine deiodinase [Mus musculus] Length = 304 Score = 558 bits (1438), Expect = 0.0 Identities = 268/277 (96%), Positives = 271/277 (97%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEE+P DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+RPDGF Sbjct: 87 NSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHGTRP R Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPHR 303 >ref|XP_003919601.1| PREDICTED: type III iodothyronine deiodinase [Papio anubis] Length = 304 Score = 541 bits (1394), Expect = 0.0 Identities = 263/277 (94%), Positives = 265/277 (95%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSQRILDYAQGNRPLVLNFGSCTXPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 303 >ref|NP_001116121.2| type III iodothyronine deiodinase [Macaca mulatta] Length = 304 Score = 541 bits (1394), Expect = 0.0 Identities = 263/277 (94%), Positives = 265/277 (95%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSQRILDYAQGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 303 >sp|P55073|IOD3_HUMAN RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|AAH17717.2| Deiodinase, iodothyronine, type III [Homo sapiens] Length = 278 Score = 539 bits (1389), Expect = 0.0 Identities = 262/277 (94%), Positives = 264/277 (95%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 1 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 61 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQ ILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QSQHILDYAQGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 181 WVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 241 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 277 >ref|XP_003846113.1| PREDICTED: type III iodothyronine deiodinase, partial [Pan paniscus] Length = 298 Score = 539 bits (1389), Expect = 0.0 Identities = 262/277 (94%), Positives = 264/277 (95%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 21 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 80 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 81 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 140 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQ ILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 141 QSQHILDYAQGNRPLVLNFGSCTXPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 200 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 201 WVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 260 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 261 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 297 >ref|NP_001353.4| type III iodothyronine deiodinase [Homo sapiens] Length = 304 Score = 539 bits (1389), Expect = 0.0 Identities = 262/277 (94%), Positives = 264/277 (95%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQ ILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSQHILDYAQGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 303 >gb|AAB35616.2| type 3 iodothyronine deiodinase [Homo sapiens] Length = 278 Score = 537 bits (1383), Expect = 0.0 Identities = 261/277 (94%), Positives = 263/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M SLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 1 MLHSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGKPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 61 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQ ILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QSQHILDYAQGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 181 WVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 241 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 277 >ref|XP_003734125.1| PREDICTED: LOW QUALITY PROTEIN: type III iodothyronine deiodinase [Callithrix jacchus] Length = 304 Score = 537 bits (1384), Expect = 0.0 Identities = 260/277 (93%), Positives = 265/277 (95%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEP+VEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPDVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QS+RILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSRRILDYAQGNRPLVLNFGSCTXPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAA+VLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYIIPQHRSLEDRVSAAKVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 303 >ref|XP_003780591.1| PREDICTED: type III iodothyronine deiodinase [Pongo abelii] Length = 304 Score = 537 bits (1383), Expect = 0.0 Identities = 261/277 (94%), Positives = 263/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQ ILDYAQG+RPLVLNFGSCT PPFMARMSAFQRLVTKYQ DVDFLIIYIEEAHPSDG Sbjct: 147 QSQHILDYAQGNRPLVLNFGSCTXPPFMARMSAFQRLVTKYQSDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 207 WVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG RPRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRR 303 >gb|EGV99748.1| Type III iodothyronine deiodinase [Cricetulus griseus] Length = 284 Score = 522 bits (1345), Expect = 0.0 Identities = 257/277 (92%), Positives = 257/277 (92%), Gaps = 20/277 (7%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 27 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF Sbjct: 87 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 QSQRILDYAQGSRPL RLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QSQRILDYAQGSRPL--------------------RLVTKYQRDVDFLIIYIEEAHPSDG 186 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 187 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 246 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR Sbjct: 247 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 283 >ref|NP_001116122.1| type III iodothyronine deiodinase [Ovis aries] sp|Q6DN07|IOD3_SHEEP RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|AAT74923.1| type 3 iodothyronine deiodinase [Ovis aries] Length = 278 Score = 521 bits (1343), Expect = 0.0 Identities = 251/277 (90%), Positives = 261/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKH L RR PE EVEL Sbjct: 1 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NS+GEEVP DDPP+CVSDDNRLCTLASL+AVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 61 NSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY+IPQHRSLEDRVSAARVLQQGAP CALVLDTM NSSSSAYGAYFERLY+IQS Sbjct: 181 WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQS 240 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YDEQLHG +PRR Sbjct: 241 GTIMYQGGRGPDGYQVSELRTWLERYDEQLHGPQPRR 277 >sp|Q5I3B1|IOD3_BOVIN RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|AAW51124.1| type III iodothyronine deiodinase [Bos taurus] gb|DAA17289.1| type III iodothyronine deiodinase [Bos taurus] Length = 278 Score = 519 bits (1337), Expect = 0.0 Identities = 249/277 (89%), Positives = 261/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLC+QTASCLVLFPRFLGTAFMLWLLDFLCIRKH L RR PE EVEL Sbjct: 1 MLRSLLLHSLRLCSQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NS+GEEVP DDPP+CVSDDNRLCTLASL+AVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 61 NSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY+IPQHRSLEDRVSAARVLQQGAP CALVLDTM NSSSSAYGAYFERLY+IQS Sbjct: 181 WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQS 240 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSE+RTWLE YDEQLHG +PRR Sbjct: 241 GTIMYQGGRGPDGYQVSEVRTWLERYDEQLHGPQPRR 277 >ref|NP_001010993.2| type III iodothyronine deiodinase [Bos taurus] Length = 301 Score = 519 bits (1337), Expect = 0.0 Identities = 249/277 (89%), Positives = 261/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLC+QTASCLVLFPRFLGTAFMLWLLDFLCIRKH L RR PE EVEL Sbjct: 24 MLRSLLLHSLRLCSQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVEL 83 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NS+GEEVP DDPP+CVSDDNRLCTLASL+AVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 84 NSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 143 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 144 QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 203 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY+IPQHRSLEDRVSAARVLQQGAP CALVLDTM NSSSSAYGAYFERLY+IQS Sbjct: 204 WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQS 263 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSE+RTWLE YDEQLHG +PRR Sbjct: 264 GTIMYQGGRGPDGYQVSEVRTWLERYDEQLHGPQPRR 300 >ref|NP_001157660.1| type III iodothyronine deiodinase [Canis lupus familiaris] Length = 304 Score = 518 bits (1335), Expect = 0.0 Identities = 247/277 (89%), Positives = 262/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEP VEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPAVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 +S+GEE+P DDPP+CVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ P+GF Sbjct: 87 DSDGEELPPDDPPVCVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPNGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAF RLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFHRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY+IPQHRSLEDRVSAA+VLQQGAP C+LVLDTMANSSSSAYGAYFERLYVIQ+ Sbjct: 207 WVTTDSPYSIPQHRSLEDRVSAAQVLQQGAPSCSLVLDTMANSSSSAYGAYFERLYVIQN 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GT+MYQGGRGPDGYQVSELRTWLE YDEQLHG +PRR Sbjct: 267 GTVMYQGGRGPDGYQVSELRTWLERYDEQLHGAQPRR 303 >ref|NP_001001625.2| type III iodothyronine deiodinase [Sus scrofa] Length = 305 Score = 518 bits (1334), Expect = 0.0 Identities = 250/277 (90%), Positives = 261/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTA MLWLLDFLCIRKH L RR PE EVEL Sbjct: 28 MLRSLLLHSLRLCAQTASCLVLFPRFLGTACMLWLLDFLCIRKHLLGRRRRGEPETEVEL 87 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NS+G+EVP DDPPICVSDDNRLCTLASL+AVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 88 NSDGDEVPPDDPPICVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 147 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 148 QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 207 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY+IPQHRSLEDRVSAARVLQQGAP C+LVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 208 WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECSLVLDTMANSSSSAYGAYFERLYVIQS 267 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YD+QLHG +PRR Sbjct: 268 GTIMYQGGRGPDGYQVSELRTWLERYDQQLHGPQPRR 304 >ref|XP_002926780.1| PREDICTED: LOW QUALITY PROTEIN: type III iodothyronine deiodinase-like [Ailuropoda melanoleuca] Length = 304 Score = 517 bits (1332), Expect = 0.0 Identities = 248/277 (89%), Positives = 261/277 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEP VEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPAVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 +S+GEEVP DDPP+CVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ P+GF Sbjct: 87 DSDGEEVPPDDPPVCVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPNGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAF RLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 147 QNQHILDYARGNRPLVLNFGSCTXPPFMARMSAFHRLVTKYQRDVDFLIIYIEEAHPSDG 206 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY+IPQHRSLEDRVSAA+VLQQGAP C+LVLDTMANSSSSAYGAYFERLYVIQ+ Sbjct: 207 WVTTDSPYSIPQHRSLEDRVSAAQVLQQGAPSCSLVLDTMANSSSSAYGAYFERLYVIQN 266 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE Y EQLHG +PRR Sbjct: 267 GTIMYQGGRGPDGYQVSELRTWLERYHEQLHGAQPRR 303 >sp|Q6QN11|IOD3_PIG RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|AAS48449.1| type III iodothyronine deiodinase [Sus scrofa] gb|ADQ20115.1| iodothyronine deiodinase type III [Sus scrofa] Length = 278 Score = 516 bits (1329), Expect = 0.0 Identities = 249/277 (89%), Positives = 260/277 (93%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M SLLLHSLRLCAQTASCLVLFPRFLGTA MLWLLDFLCIRKH L RR PE EVEL Sbjct: 1 MLHSLLLHSLRLCAQTASCLVLFPRFLGTACMLWLLDFLCIRKHLLGRRRRGEPETEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NS+G+EVP DDPPICVSDDNRLCTLASL+AVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 61 NSDGDEVPPDDPPICVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WVTTDSPY+IPQHRSLEDRVSAARVLQQGAP C+LVLDTMANSSSSAYGAYFERLYVIQS Sbjct: 181 WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECSLVLDTMANSSSSAYGAYFERLYVIQS 240 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 GTIMYQGGRGPDGYQVSELRTWLE YD+QLHG +PRR Sbjct: 241 GTIMYQGGRGPDGYQVSELRTWLERYDQQLHGPQPRR 277 >ref|XP_004001503.1| PREDICTED: type III iodothyronine deiodinase-like [Felis catus] Length = 307 Score = 511 bits (1315), Expect = e-180 Identities = 247/280 (88%), Positives = 260/280 (92%), Gaps = 3/280 (1%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL---RRRHPDHPEPE 57 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RRR PEP Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRRRRGQPEPA 86 Query: 58 VELNSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRP 117 EL+S+GEEVP DDPP+CVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ P Sbjct: 87 AELDSDGEEVPPDDPPVCVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLP 146 Query: 118 DGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHP 177 +GFQ+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHP Sbjct: 147 NGFQNQHILDYARGNRPLVLNFGSCTXPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHP 206 Query: 178 SDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYV 237 SDGWVTTDSPY+IPQHRSLEDRVSAA VLQQGAP C+LVLDTMANSSSSAYGAYFERLYV Sbjct: 207 SDGWVTTDSPYSIPQHRSLEDRVSAAEVLQQGAPSCSLVLDTMANSSSSAYGAYFERLYV 266 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 +Q+GTIMYQGGRGPDGYQVSELRTWLE YD QL G +PRR Sbjct: 267 VQNGTIMYQGGRGPDGYQVSELRTWLERYDAQLRGGQPRR 306 >gb|ACX42083.1| type III iodothyronine deiodinase, partial [Cricetus cricetus] Length = 239 Score = 486 bits (1250), Expect = e-172 Identities = 236/239 (98%), Positives = 236/239 (98%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 1 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF Sbjct: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Q QRILDYAQGSRPLVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG Sbjct: 121 QRQRILDYAQGSRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQ 239 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQ Sbjct: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQ 239 >ref|XP_001917251.1| PREDICTED: LOW QUALITY PROTEIN: type III iodothyronine deiodinase, partial [Equus caballus] Length = 240 Score = 442 bits (1138), Expect = e-155 Identities = 212/240 (88%), Positives = 222/240 (92%) Query: 37 DFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQK 96 DFLCIRKHFL R+ PEPEVELN +GEEVP DDPPICVSDDNRLCT KAVW+GQK Sbjct: 1 DFLCIRKHFLSRQRRGGPEPEVELNCDGEEVPPDDPPICVSDDNRLCTWRRXKAVWYGQK 60 Query: 97 LDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQR 156 LDFFKQAHEGGPAPNSEV+ PDGFQ+Q ILDYA+G+RPLVLNFGSCT PPFMARMSAF+R Sbjct: 61 LDFFKQAHEGGPAPNSEVVLPDGFQNQHILDYARGNRPLVLNFGSCTXPPFMARMSAFRR 120 Query: 157 LVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALV 216 LVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPY IPQHRSLEDRVSAARVLQQGAPGC+LV Sbjct: 121 LVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCSLV 180 Query: 217 LDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPR 276 LDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE YDEQL G +PR Sbjct: 181 LDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLRGAQPR 240 >ref|XP_002721754.1| PREDICTED: deiodinase, iodothyronine, type III [Oryctolagus cuniculus] Length = 281 Score = 414 bits (1063), Expect = e-143 Identities = 213/279 (76%), Positives = 218/279 (78%), Gaps = 27/279 (9%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL-RRRHPDHPEPEVE 59 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKH L RRR PEPEVE Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHILGRRRRRGQPEPEVE 86 Query: 60 LNSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPA-PNSEVIRPD 118 LNS+GEEV DDPPICVSDDNRLCTLASL+AVWHG F + G P P P Sbjct: 87 LNSDGEEVSPDDPPICVSDDNRLCTLASLRAVWHGPAAGFLQAGARGRPRRPTPRWFCPT 146 Query: 119 GFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPS 178 FQSQRILDYAQG+RPL YQRDVDFLIIYIEEAHPS Sbjct: 147 AFQSQRILDYAQGNRPL-------------------------YQRDVDFLIIYIEEAHPS 181 Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGWVTTDSPY IPQHRSLEDRV AARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI Sbjct: 182 DGWVTTDSPYVIPQHRSLEDRVRAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 241 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRPRR 277 QSGTIMYQGGRGPDGYQVSELR WL YD+QL G RPRR Sbjct: 242 QSGTIMYQGGRGPDGYQVSELRAWLRRYDQQLRGARPRR 280 >ref|XP_003314554.1| PREDICTED: LOW QUALITY PROTEIN: type III iodothyronine deiodinase, partial [Pan troglodytes] Length = 204 Score = 402 bits (1032), Expect = e-139 Identities = 194/203 (95%), Positives = 196/203 (96%) Query: 75 CVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRP 134 CVSD NRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGFQSQ ILDYAQG+RP Sbjct: 1 CVSDXNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQHILDYAQGNRP 60 Query: 135 LVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHR 194 LVLNFGSCT PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPY IPQHR Sbjct: 61 LVLNFGSCTXPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHR 120 Query: 195 SLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGY 254 SLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGY Sbjct: 121 SLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGY 180 Query: 255 QVSELRTWLEHYDEQLHGTRPRR 277 QVSELRTWLE YDEQLHG RPRR Sbjct: 181 QVSELRTWLERYDEQLHGARPRR 203 >ref|NP_001116120.1| type III iodothyronine deiodinase [Gallus gallus] Length = 274 Score = 348 bits (892), Expect = e-117 Identities = 167/270 (61%), Positives = 208/270 (77%), Gaps = 6/270 (2%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M SL H+L+L Q A+C++LFPRFL TA MLWLLDFLCIRK L P E E Sbjct: 1 MLHSLGAHTLQLLTQAAACILLFPRFLLTAVMLWLLDFLCIRKKMLTM-----PTAE-EA 54 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 GE P DDPP+CVSD NR+ TL SLKAVWHGQKLDFFK AH G PAPN EVI+ DG Sbjct: 55 AGAGEGPPPDDPPVCVSDSNRMFTLESLKAVWHGQKLDFFKSAHVGSPAPNPEVIQLDGQ 114 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 + RILD+A+G RPL+LNFGSCT PPFMAR+ +F+RL + DFL++YIEEAHPSDG Sbjct: 115 KRLRILDFARGKRPLILNFGSCTUPPFMARLRSFRRLAAHFVDIADFLLVYIEEAHPSDG 174 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WV++D+ Y+IP+H+ L+DR+ AA+++++GAP C L +DTM N+SS+AYGAYFERLYVIQ Sbjct: 175 WVSSDAAYSIPKHQCLQDRLRAAQLMREGAPDCPLAVDTMDNASSAAYGAYFERLYVIQE 234 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQL 270 +MYQGGRGP+GY++SELR+WL+ Y +L Sbjct: 235 EKVMYQGGRGPEGYKISELRSWLDQYKTRL 264 >gb|ACH42530.1| deiodinase iodothyronine type III [Ornithorhynchus anatinus] Length = 298 Score = 348 bits (894), Expect = e-117 Identities = 170/286 (59%), Positives = 209/286 (73%), Gaps = 11/286 (3%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEV-- 58 M SL +H+ L AQ A+C +LFPRFL TA MLWLLDFLCIRK L PE E Sbjct: 1 MLHSLRVHTSALLAQAAACFLLFPRFLLTALMLWLLDFLCIRKKVLHGPGEAGPEAEQGP 60 Query: 59 ELNSEGE---------EVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPA 109 + +GE E P DDPP+ VSD NRLCTL SLKAVWHGQKLD FK A G PA Sbjct: 61 QRARDGEAPAAGPAPPEPPPDDPPVLVSDSNRLCTLESLKAVWHGQKLDHFKSARVGAPA 120 Query: 110 PNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLI 169 PN V+ PDG +R+LD+A+G+RPLVLNFGSCT PPFM R+ +FQRL ++ D L+ Sbjct: 121 PNPVVVAPDGPTRRRLLDFARGARPLVLNFGSCTUPPFMVRLRSFQRLAARFLDVADCLL 180 Query: 170 IYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYG 229 +YIEEAHPSDGWV++D+PY IP+HR L+DR+ AAR++Q+GAPGC L +DTM N++S+AYG Sbjct: 181 VYIEEAHPSDGWVSSDAPYDIPKHRCLQDRLRAARLMQRGAPGCRLAVDTMDNAASAAYG 240 Query: 230 AYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTRP 275 AYFERLYV+Q ++YQGGRGP+GY++SELR WLE Y +L G P Sbjct: 241 AYFERLYVVQDARVVYQGGRGPEGYKISELRLWLEQYRLRLRGPGP 286 >ref|XP_003756592.1| PREDICTED: type III iodothyronine deiodinase [Sarcophilus harrisii] Length = 330 Score = 342 bits (878), Expect = e-114 Identities = 168/284 (59%), Positives = 205/284 (72%), Gaps = 17/284 (5%) Query: 4 SLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKH-FLRRRHPDHPEPEVELNS 62 SLL+H+L Q A+C L PRFL TA LWLLDFLCIRK LRRRH E + Sbjct: 36 SLLVHTLGFLTQVAACCFLGPRFLATALTLWLLDFLCIRKKVLLRRRHEGEAEEPWKAGG 95 Query: 63 EGEE----------------VPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEG 106 G +P DDPPI VSD NRLCT+ SLKAVWHGQK+DFFK AH+G Sbjct: 96 GGSRGGGEEEDGAAVILFPGLPPDDPPIWVSDSNRLCTIESLKAVWHGQKMDFFKTAHKG 155 Query: 107 GPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVD 166 APN EVI+ DG + RILD+A+GSRPLVLNFGSCT PPF AR+ AFQRL + + D Sbjct: 156 SLAPNPEVIQLDGLKRLRILDFARGSRPLVLNFGSCTXPPFTARLRAFQRLASTFLDIAD 215 Query: 167 FLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSS 226 FL++YIEEAHPSDGW ++D+ Y IP+H+ L+DR+ AAR+LQ+GAPGC L +DTM N+SS+ Sbjct: 216 FLLVYIEEAHPSDGWASSDAAYDIPKHQCLQDRLRAARLLQEGAPGCLLAVDTMDNASSA 275 Query: 227 AYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQL 270 AYGAY ERLY+IQ +MYQGGRGP+GY++SELR WL+ Y ++L Sbjct: 276 AYGAYSERLYIIQEARVMYQGGRGPEGYKISELRHWLDQYKDRL 319 >gb|ACH42531.1| deiodinase iodothyronine type III [Macropus eugenii] Length = 330 Score = 341 bits (874), Expect = e-113 Identities = 170/284 (59%), Positives = 206/284 (72%), Gaps = 17/284 (5%) Query: 4 SLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL--RRRHPDHPEPEVELN 61 SLL+H+L Q A+C L PRFL TA LWLLDFLCIRK L RR D +P Sbjct: 36 SLLVHTLGFLTQVAACCFLGPRFLATAVTLWLLDFLCIRKKVLMRHRREGDAEDPWKAGG 95 Query: 62 SEG-----EE----------VPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEG 106 G EE +P DDPPI VSD NR CT+ SLKAVWHGQK+DFFK AH+G Sbjct: 96 GGGGGGREEEDAAAVILSPGLPPDDPPIWVSDSNRFCTIESLKAVWHGQKMDFFKTAHKG 155 Query: 107 GPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVD 166 PAPN EVI+ DG + RILD+A+GSRPLVLNFGSCT PPF AR+ AFQ L + + D Sbjct: 156 SPAPNPEVIQLDGLKRLRILDFARGSRPLVLNFGSCTUPPFTARLRAFQHLASTFLDIAD 215 Query: 167 FLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSS 226 FL++YIEEAHPSDGWVT+D+ Y IP+H+ L+DR+ AAR+LQ+GAPGC L +DTM N+SS+ Sbjct: 216 FLLVYIEEAHPSDGWVTSDAAYDIPKHQCLQDRLRAARLLQEGAPGCLLAVDTMDNASSA 275 Query: 227 AYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQL 270 AYGAY ERLY+IQ +MYQGGRGP+GY++SELR WL+ Y ++L Sbjct: 276 AYGAYSERLYIIQEARVMYQGGRGPEGYKISELRHWLDQYKDRL 319 >sp|O42412|IOD3_CHICK RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase Length = 258 Score = 338 bits (866), Expect = e-113 Identities = 161/254 (63%), Positives = 199/254 (78%), Gaps = 6/254 (2%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A+C++LFPRFL TA MLWLLDFLCIRK L P E E GE P DDPP+CV Sbjct: 1 AACILLFPRFLLTAVMLWLLDFLCIRKKMLTM-----PTAE-EAAGAGEGPPPDDPPVCV 54 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLV 136 SD NR+ TL SLKAVWHGQKLDFFK AH G PAPN EVI+ DG + RILD+A+G RPL+ Sbjct: 55 SDSNRMFTLESLKAVWHGQKLDFFKSAHVGSPAPNPEVIQLDGQKRLRILDFARGKRPLI 114 Query: 137 LNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSL 196 LNFGSCT PPFMAR+ +F+RL + DFL++YIEEAHPSDGWV++D+ Y+IP+H+ L Sbjct: 115 LNFGSCTUPPFMARLRSFRRLAADFVDIADFLLVYIEEAHPSDGWVSSDAAYSIPKHQCL 174 Query: 197 EDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 +DR+ AA+++++GAP C L +DTM N+SS+AYGAYFERLYVIQ +MYQGGRGP+GY++ Sbjct: 175 QDRLRAAQLMREGAPDCPLAVDTMDNASSAAYGAYFERLYVIQEEKVMYQGGRGPEGYKI 234 Query: 257 SELRTWLEHYDEQL 270 SELRTWL+ Y +L Sbjct: 235 SELRTWLDQYKTRL 248 >emb|CAA72136.1| type III iodothyronine deiodinase [Gallus gallus] Length = 258 Score = 338 bits (866), Expect = e-113 Identities = 161/254 (63%), Positives = 199/254 (78%), Gaps = 6/254 (2%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A+C++LFPRFL TA MLWLLDFLCIRK L P E E GE P DDPP+CV Sbjct: 1 AACILLFPRFLLTAVMLWLLDFLCIRKKMLTM-----PTAE-EAAGAGEGPPPDDPPVCV 54 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLV 136 SD NR+ TL SLKAVWHGQKLDFFK AH G PAPN EVI+ DG + RILD+A+G RPL+ Sbjct: 55 SDSNRMFTLESLKAVWHGQKLDFFKSAHVGSPAPNPEVIQLDGQKRLRILDFARGKRPLI 114 Query: 137 LNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSL 196 LNFGSCT PPFMAR+ +F+RL + DFL++YIEEAHPSDGWV++D+ Y+IP+H+ L Sbjct: 115 LNFGSCTXPPFMARLRSFRRLAADFVDIADFLLVYIEEAHPSDGWVSSDAAYSIPKHQCL 174 Query: 197 EDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 +DR+ AA+++++GAP C L +DTM N+SS+AYGAYFERLYVIQ +MYQGGRGP+GY++ Sbjct: 175 QDRLRAAQLMREGAPDCPLAVDTMDNASSAAYGAYFERLYVIQEEKVMYQGGRGPEGYKI 234 Query: 257 SELRTWLEHYDEQL 270 SELRTWL+ Y +L Sbjct: 235 SELRTWLDQYKTRL 248 >gb|ACZ59442.1| hepatic iodothyronine deiodinase type III [Pituophis deppei] Length = 286 Score = 338 bits (866), Expect = e-113 Identities = 163/275 (59%), Positives = 204/275 (74%), Gaps = 5/275 (1%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M SL H+L+ +Q A+ ++L PRFL TA M WLLDFLCIRK L P E EL Sbjct: 1 MLHSLGAHTLQALSQVAAGVLLLPRFLLTAVMRWLLDFLCIRKKLLLTAAAATPGEEQEL 60 Query: 61 NSEGEE-----VPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVI 115 +E + P DDPP+CVSD NR+ TL SLKAVWHGQKLDFFK AH G APN EV+ Sbjct: 61 AAEDGDSSDGTCPPDDPPLCVSDSNRMFTLESLKAVWHGQKLDFFKAAHVGATAPNPEVV 120 Query: 116 RPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEA 175 + DG RILDYA+G RPL+LNFGSCT PPFMAR+ AF+RL T++ DFL++YIEEA Sbjct: 121 QLDGRTRLRILDYARGKRPLILNFGSCTUPPFMARLRAFERLATRFVDVADFLLVYIEEA 180 Query: 176 HPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERL 235 HPSDGWV++D+ Y IP+H+ L+DR+ AA+++++GAPGC L +DTM N+SS+AYGAYFER Sbjct: 181 HPSDGWVSSDAAYDIPKHQCLQDRLRAAQLMKEGAPGCPLAVDTMDNASSAAYGAYFERT 240 Query: 236 YVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQL 270 Y+IQ +MYQGGRGP+GY++SELR WL+ Y L Sbjct: 241 YIIQERKVMYQGGRGPEGYKISELRRWLDQYKSSL 275 >gb|AEO36972.1| deiodinase 3 [Microtus arvalis] Length = 159 Score = 330 bits (845), Expect = e-111 Identities = 156/159 (98%), Positives = 156/159 (98%) Query: 29 TAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDDNRLCTLASL 88 TAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVP DDPPICVSDDNRLCTLASL Sbjct: 1 TAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASL 60 Query: 89 KAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFM 148 KAVWHGQKLDFFKQAHEGGPAPNSEVIRPD FQSQRILDYAQGSRPLVLNFGSCT PPFM Sbjct: 61 KAVWHGQKLDFFKQAHEGGPAPNSEVIRPDSFQSQRILDYAQGSRPLVLNFGSCTUPPFM 120 Query: 149 ARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSP 187 ARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSP Sbjct: 121 ARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSP 159 >gb|ABX60542.1| iodothyronine deiodinase type 3 [Chiloscyllium punctatum] Length = 259 Score = 332 bits (852), Expect = e-111 Identities = 157/262 (59%), Positives = 197/262 (75%), Gaps = 12/262 (4%) Query: 12 LCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADD 71 L + + L+L PRF TAFMLWLLD LCIRK L +R E E ADD Sbjct: 3 LLKEIVAILILLPRFFITAFMLWLLDILCIRKRLLPKRR------------EQTEGSADD 50 Query: 72 PPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQG 131 PP+CVSD NR+ TL S+KA+W+GQKLDFFK AH G PAPN+EV++ + R+LDY++G Sbjct: 51 PPLCVSDTNRMFTLESVKAIWYGQKLDFFKSAHVGSPAPNTEVVQLQDQRKVRLLDYSRG 110 Query: 132 SRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIP 191 +RPLVLNFGSCT PPFMAR+ +FQR+ T+Y DFL+IYIEEAHPSDGWV+TD+PY IP Sbjct: 111 ARPLVLNFGSCTUPPFMARLKSFQRVATQYADIADFLLIYIEEAHPSDGWVSTDAPYNIP 170 Query: 192 QHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGP 251 +HRSLEDR+ AA ++ + +PGC +V DTM NSS+SAYGAYFERLYV++ ++YQGGRGP Sbjct: 171 RHRSLEDRLKAASLIDKESPGCLVVADTMDNSSNSAYGAYFERLYVLRDQKVVYQGGRGP 230 Query: 252 DGYQVSELRTWLEHYDEQLHGT 273 +GY++SELR WLE Y Q H + Sbjct: 231 EGYKISELRLWLEQYKSQSHNS 252 >ref|NP_001107139.2| deiodinase, iodothyronine, type III [Xenopus (Silurana) tropicalis] Length = 271 Score = 328 bits (840), Expect = e-109 Identities = 154/266 (57%), Positives = 199/266 (74%), Gaps = 12/266 (4%) Query: 8 HSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEV 67 H+ +L Q A+C +L PRFL TA MLWLLDF CIR+ L + PE+E Sbjct: 8 HTSKLLKQVAACCLLLPRFLLTALMLWLLDFQCIRRRVLVTAR-EESSPELE-------- 58 Query: 68 PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILD 127 DPP+CVSD NR+CT+ SL+AVWHGQKLD+FK AH G APN+EV+ +G + RILD Sbjct: 59 ---DPPLCVSDSNRMCTVESLRAVWHGQKLDYFKSAHLGSSAPNTEVVMLEGRRLCRILD 115 Query: 128 YAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSP 187 ++QG RPLV+NFGSCT PPFMAR+ A++RL ++ DFL++YIEEAHPSDGWV+TD+ Sbjct: 116 FSQGKRPLVVNFGSCTUPPFMARLQAYRRLAAQHVGTADFLLVYIEEAHPSDGWVSTDAS 175 Query: 188 YTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQG 247 Y IPQH+ L+DR++AA+++ QG PGC +V DTM NSS++AYGAYFERLY+I G ++YQG Sbjct: 176 YQIPQHQCLQDRLAAAQLMLQGVPGCRVVADTMDNSSNAAYGAYFERLYIILEGKVVYQG 235 Query: 248 GRGPDGYQVSELRTWLEHYDEQLHGT 273 GRGP+GY++SELR WLE Y + GT Sbjct: 236 GRGPEGYKISELRMWLEQYQQGTIGT 261 >ref|NP_001081332.1| type III iodothyronine deiodinase [Xenopus laevis] sp|P49899|IOD3_XENLA RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase; AltName: Full=XL-15 gb|AAA49971.2| iodothyronine 5-deiodinase type III [Xenopus laevis] Length = 271 Score = 324 bits (830), Expect = e-107 Identities = 150/267 (56%), Positives = 199/267 (74%), Gaps = 12/267 (4%) Query: 8 HSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEV 67 H+ +L Q A+C +L PRFL T MLWLLDF CIR+ L E Sbjct: 8 HTGKLVKQVAACCLLLPRFLLTGLMLWLLDFQCIRRRVLLTAR------------EESTA 55 Query: 68 PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILD 127 +DPP+CVSD NR+CT+ SL+AVWHGQKLD+FK AH G APN+EV+ +G + +ILD Sbjct: 56 EHEDPPLCVSDSNRMCTVESLRAVWHGQKLDYFKSAHLGCSAPNTEVVMLEGRRLCKILD 115 Query: 128 YAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSP 187 ++QG RPLV+NFGSCT PPFMAR+ A++RL ++ DFL++YIEEAHPSDGW++TD+ Sbjct: 116 FSQGKRPLVVNFGSCTUPPFMARLQAYRRLAAQHVGIADFLLVYIEEAHPSDGWLSTDAS 175 Query: 188 YTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQG 247 Y IPQH+ L+DR++AA+++ QGAPGC +V+DTM NSS++AYGAYFERLY++ G ++YQG Sbjct: 176 YQIPQHQCLQDRLAAAQLMLQGAPGCRVVVDTMDNSSNAAYGAYFERLYIVLEGKVVYQG 235 Query: 248 GRGPDGYQVSELRTWLEHYDEQLHGTR 274 GRGP+GY++SELR WLE Y + L GT+ Sbjct: 236 GRGPEGYKISELRMWLEQYQQGLMGTK 262 >sp|P49898|IOD3_RANCA RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|AAA82941.2| 5-deiodinase type III [Rana catesbeiana] Length = 269 Score = 315 bits (807), Expect = e-104 Identities = 150/263 (57%), Positives = 192/263 (73%), Gaps = 12/263 (4%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHP-EPEVELNSEGEEVPA 69 RL Q +C +L PRFL T +LWLLDF C+R+ +R + P PE E Sbjct: 10 RLLQQLLACCLLLPRFLLTVLLLWLLDFPCVRRRVIRGAKEEDPGAPERE---------- 59 Query: 70 DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYA 129 DPP+CVSD NR+CTL SLKAVW+GQKLDFFK AH GG APN+EV+ +G + RILD++ Sbjct: 60 -DPPLCVSDTNRMCTLESLKAVWYGQKLDFFKSAHLGGGAPNTEVVTLEGQRLCRILDFS 118 Query: 130 QGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYT 189 +G RPLVLNFGSCT PPFMAR+ A+QRL + DFL++YIEEAHP DGW++TD+ Y Sbjct: 119 KGHRPLVLNFGSCTUPPFMARLQAYQRLAAQRLDFADFLLVYIEEAHPCDGWLSTDAAYQ 178 Query: 190 IPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGR 249 IP H+ L+DR+ AA+++ QGAPGC +V DTM N+S++AYGAYFERLYVI G ++YQGGR Sbjct: 179 IPTHQCLQDRLRAAQLMLQGAPGCRVVADTMTNASNAAYGAYFERLYVILDGKVVYQGGR 238 Query: 250 GPDGYQVSELRTWLEHYDEQLHG 272 GP+GY++ ELR WL+ Y + G Sbjct: 239 GPEGYKIGELRNWLDQYQTRATG 261 >gb|ACF47589.1| deiodinase iodothyronine type III [Peromyscus polionotus subgriseus] gb|ACF47590.1| deiodinase iodothyronine type III [Peromyscus maniculatus bairdii] Length = 148 Score = 307 bits (786), Expect = e-103 Identities = 145/148 (97%), Positives = 146/148 (98%) Query: 41 IRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFF 100 IRKHFLRRRHPDHPEPEVELNSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFF Sbjct: 1 IRKHFLRRRHPDHPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFF 60 Query: 101 KQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTK 160 KQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT PPFMARMSAFQRLVTK Sbjct: 61 KQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCTUPPFMARMSAFQRLVTK 120 Query: 161 YQRDVDFLIIYIEEAHPSDGWVTTDSPY 188 YQRDVDFLIIYIEEAHPSDGWVT+DSPY Sbjct: 121 YQRDVDFLIIYIEEAHPSDGWVTSDSPY 148 >gb|AAR05175.1| deiodinase type III [Neoceratodus forsteri] Length = 271 Score = 311 bits (796), Expect = e-102 Identities = 146/274 (53%), Positives = 201/274 (73%), Gaps = 11/274 (4%) Query: 1 MFRSLLLHSLR-LCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVE 59 M++S +H++ + Q +C +L PRFL TA MLWLLDFLC+R+ L + Sbjct: 1 MYQSSGVHTMNEVLKQAFACFILLPRFLVTALMLWLLDFLCVRRRVLLH---------MS 51 Query: 60 LNSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDG 119 E ++P D+P +CVSD NR+ TL SL+AVWH QKLDFFK AH G APN+EVI+ +G Sbjct: 52 RRQEASDLP-DEPELCVSDSNRMFTLKSLRAVWHDQKLDFFKAAHIGLVAPNTEVIKLEG 110 Query: 120 FQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSD 179 + +IL++ G RPL+LNFGSCT PPFMAR+ AF+ + T+Y+ DFL+IYIEEAHPSD Sbjct: 111 QRKAKILEFGGGKRPLILNFGSCTUPPFMARLKAFRGVATQYKDVADFLLIYIEEAHPSD 170 Query: 180 GWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQ 239 GWV+TD+PY IP+H+ LEDR+ AA+++ PGC +V+DTM N+S++AYGA+FERLY++Q Sbjct: 171 GWVSTDAPYQIPKHQCLEDRLKAAQLMNLEIPGCLVVVDTMDNASNAAYGAFFERLYIVQ 230 Query: 240 SGTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGT 273 ++YQGGRGP+GY++SEL+ WL+ Y QL + Sbjct: 231 QERVVYQGGRGPEGYKISELKNWLDQYKSQLQNS 264 >emb|CAP16956.1| putative thyroxine 5-deiodinase [Solea senegalensis] Length = 268 Score = 302 bits (774), Expect = 3e-99 Identities = 146/264 (55%), Positives = 188/264 (71%), Gaps = 13/264 (4%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPAD 70 R A CL+L PRFL A MLWLLDFLCIRK L++ PE Sbjct: 12 RALKHAALCLMLLPRFLLAAVMLWLLDFLCIRKKVLQKMGERQDSPE------------- 58 Query: 71 DPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQ 130 DPP+CVSD N++ TL SL+AVW+GQKLDFFK AH G APN+EV+ + RILD + Sbjct: 59 DPPVCVSDSNKMFTLESLRAVWYGQKLDFFKSAHLGRTAPNTEVVLVQERRRVRILDCMK 118 Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTI 190 G RPL+LNFGSC+ PPFM R++AFQR+V +Y DFL++YIEEAHPSDGWV++D+PY I Sbjct: 119 GKRPLILNFGSCSUPPFMTRLAAFQRVVNQYADIADFLVVYIEEAHPSDGWVSSDAPYQI 178 Query: 191 PQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRG 250 P+HR LEDR++AA+++ + PG +V+D M NSS++AYGAYFERLY+I+ ++YQGGRG Sbjct: 179 PKHRCLEDRLTAAQLMLRELPGGNVVVDDMDNSSNAAYGAYFERLYIIRDERVVYQGGRG 238 Query: 251 PDGYQVSELRTWLEHYDEQLHGTR 274 P+GY++S LR WLE Y L +R Sbjct: 239 PEGYRISGLRNWLEQYKSDLMNSR 262 >emb|CAA71997.1| Type III iodothyronine deiodinase [Oreochromis niloticus] Length = 267 Score = 302 bits (773), Expect = 4e-99 Identities = 145/254 (57%), Positives = 186/254 (73%), Gaps = 13/254 (5%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A CL+L PRFL A MLWLLDFLCIRK L + E +E P DDPP+CV Sbjct: 17 ALCLMLLPRFLLAAVMLWLLDFLCIRKKVLLKM------------GERQESP-DDPPVCV 63 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLV 136 SD N++ TL SL+AVWHGQKLDF K AH G PAPN+EV+ + RILD +G+RPL+ Sbjct: 64 SDSNKMFTLESLRAVWHGQKLDFLKSAHLGHPAPNTEVVLVQERKQVRILDCVKGNRPLI 123 Query: 137 LNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSL 196 LNFGSC+ PPFM R++AFQR+V++Y DFL++YIEEAHPSDGWV++D+PY IP+HR L Sbjct: 124 LNFGSCSXPPFMTRLTAFQRVVSQYADIADFLVVYIEEAHPSDGWVSSDAPYQIPKHRCL 183 Query: 197 EDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 EDR+ AA+++ P +V+D M NS ++AYGAYFERLY+++ ++YQGGRGP+GY++ Sbjct: 184 EDRLRAAQLMLTEVPETNVVVDNMDNSCNAAYGAYFERLYIVRDEKVVYQGGRGPEGYRI 243 Query: 257 SELRTWLEHYDEQL 270 SELR WLE Y L Sbjct: 244 SELRNWLEQYRNDL 257 >gb|ABP64747.1| deiodinase type 3 [Carassius auratus] Length = 274 Score = 301 bits (771), Expect = 9e-99 Identities = 147/260 (56%), Positives = 187/260 (71%), Gaps = 16/260 (6%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A CL+L PRFL A ML LDFLCIR+ L + P DDPP+CV Sbjct: 20 AVCLMLLPRFLLAAVMLLFLDFLCIRRKVLTKMRESDLSP-------------DDPPLCV 66 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ---SQRILDYAQGSR 133 SD N++ TL SL+AVW+G KLDFFK A GG APN+EV+ D +QRILDYA+G R Sbjct: 67 SDSNKMFTLESLRAVWYGHKLDFFKTARLGGAAPNTEVVPLDSASRRGAQRILDYARGRR 126 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PL+LNFGSC+ PPFM R++AFQR+ +Y D L++YIEEAHPSDGWV++D+PY IPQH Sbjct: 127 PLILNFGSCSUPPFMTRLAAFQRVARQYADIADSLLVYIEEAHPSDGWVSSDAPYQIPQH 186 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 + LEDR+ AA+++ + APG A+V+DTM NSS+SAYGAYFERLY+++ ++YQGGRGP+G Sbjct: 187 QCLEDRLRAAQLMNREAPGSAVVVDTMENSSNSAYGAYFERLYILKDDKVVYQGGRGPEG 246 Query: 254 YQVSELRTWLEHYDEQLHGT 273 Y+VSELR WLE Y L + Sbjct: 247 YRVSELRDWLERYRSDLEAS 266 >gb|EDL18680.1| deiodinase, iodothyronine type III [Mus musculus] gb|EDL97515.1| deiodinase, iodothyronine, type III [Rattus norvegicus] Length = 143 Score = 295 bits (755), Expect = 3e-98 Identities = 138/143 (96%), Positives = 141/143 (98%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL Sbjct: 1 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEE+P DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+RPDGF Sbjct: 61 NSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT 143 QSQRILDYAQG+RPLVLNFGSCT Sbjct: 121 QSQRILDYAQGTRPLVLNFGSCT 143 >sp|A7YD35|IOD3_SPAAU RecName: Full=Type III iodothyronine deiodinase; AltName: Full=5DIII; AltName: Full=DIOIII; AltName: Full=Type 3 DI; AltName: Full=Type-III 5'-deiodinase gb|ABK20156.1| iodothyronine deiodinase 3 [Sparus aurata] Length = 267 Score = 298 bits (764), Expect = 8e-98 Identities = 144/256 (56%), Positives = 186/256 (72%), Gaps = 13/256 (5%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPAD 70 R A CL+L PRFL A MLWLLDFLCIRK L + E ++ P D Sbjct: 11 RALKHAALCLMLLPRFLLAAVMLWLLDFLCIRKKVLLKM------------GERQDGP-D 57 Query: 71 DPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQ 130 DPP+CVSD N++ TL SL+AVW+GQKLDF K AH G APN+EV+ + RILD + Sbjct: 58 DPPVCVSDSNKMFTLESLRAVWYGQKLDFLKSAHLGRTAPNTEVMLVQERRQVRILDCMK 117 Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTI 190 G RPL+LNFGSC+ PPFM R++AFQR+V++Y DFL++YIEEAHPSDGWV++D+PY I Sbjct: 118 GKRPLILNFGSCSUPPFMTRLAAFQRVVSQYADIADFLVVYIEEAHPSDGWVSSDAPYQI 177 Query: 191 PQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRG 250 P+HR LEDR+ AA+++ PG +V+D M NSS++AYGAYFERLY+++ ++YQGGRG Sbjct: 178 PKHRCLEDRLRAAQLMLAEVPGSNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRG 237 Query: 251 PDGYQVSELRTWLEHY 266 P+GY++SELR WLE Y Sbjct: 238 PEGYRISELRNWLEQY 253 >dbj|BAG15908.1| iodothyronine deiodinase type III [Paralichthys olivaceus] Length = 259 Score = 298 bits (762), Expect = 1e-97 Identities = 144/260 (55%), Positives = 187/260 (71%), Gaps = 13/260 (5%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPAD 70 R A CL+L PRFL A MLWLLDFLCIRK L + E ++ P D Sbjct: 3 RALKHAALCLMLLPRFLLAAVMLWLLDFLCIRKKVLLKM------------GERQDGP-D 49 Query: 71 DPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQ 130 DPP+CVSD N++ TL SL+AVW+GQ+LDFFK AH G APN+EV+ + RILD + Sbjct: 50 DPPVCVSDSNKMFTLESLRAVWYGQRLDFFKSAHLGRAAPNTEVVLVQEGRQVRILDCMK 109 Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTI 190 G RPL+LNFGSC+ PPFM R++AFQR+V++Y DFL++YIEEAHPSDGWV++D+P+ I Sbjct: 110 GKRPLILNFGSCSUPPFMTRLAAFQRVVSQYADIADFLVVYIEEAHPSDGWVSSDAPFQI 169 Query: 191 PQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRG 250 P+HR LEDR+ AA+++ PG +V+D M NSS++AYGAYFERLY+++ ++YQGGRG Sbjct: 170 PKHRCLEDRLRAAQLMLSEVPGGNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRG 229 Query: 251 PDGYQVSELRTWLEHYDEQL 270 P+GYQ+S LR WLE Y L Sbjct: 230 PEGYQISGLRDWLEQYRSDL 249 >ref|NP_001129619.1| type III iodothyronine deiodinase b [Takifugu rubripes] dbj|BAG12774.1| iodothyronine deiodinase type III [Takifugu rubripes] Length = 262 Score = 295 bits (756), Expect = 1e-96 Identities = 142/265 (53%), Positives = 186/265 (70%), Gaps = 13/265 (4%) Query: 6 LLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGE 65 ++++++ VL PRFL A M WLLDFLCIRK R + + Sbjct: 1 MMNTIKSIKNALVFFVLLPRFLVAAVMFWLLDFLCIRKRVFFRM-------------KEQ 47 Query: 66 EVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRI 125 E A DPP+C+SD NRL T+ SLKAVWHG KLDF K AH G APN+EV++ + + RI Sbjct: 48 EDDAVDPPLCISDSNRLFTVESLKAVWHGHKLDFLKAAHLGQGAPNTEVVQLEDQRRSRI 107 Query: 126 LDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTD 185 LDYA+ RPL+LNFGSCT PPFMAR+ AFQ +V + D +++YIEEAHPSDGWV+TD Sbjct: 108 LDYAKDKRPLILNFGSCTUPPFMARLKAFQGVVEQNADIADSVVVYIEEAHPSDGWVSTD 167 Query: 186 SPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMY 245 +PY IP+HR L DR+ AA++++ PGC +V+D+M NSS+ AYGAYF+RLY++Q G I+Y Sbjct: 168 APYQIPKHRCLADRLGAAQLMRLEVPGCLIVVDSMENSSNVAYGAYFDRLYILQEGKIVY 227 Query: 246 QGGRGPDGYQVSELRTWLEHYDEQL 270 QGGRGP+GY+++ELR WL Y E L Sbjct: 228 QGGRGPEGYRITELRDWLVEYRESL 252 >gb|ADD82415.1| iodothyronine deiodinase type 3 [Chrysiptera cyanea] Length = 267 Score = 295 bits (756), Expect = 1e-96 Identities = 143/260 (55%), Positives = 185/260 (71%), Gaps = 13/260 (5%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPAD 70 R A L+L PRFL A MLWLLDFLCIRK L L + +D Sbjct: 11 RALKHAALSLMLLPRFLLAAVMLWLLDFLCIRKKVL-------------LKMGERQDGSD 57 Query: 71 DPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQ 130 DPP+CVSD N++ TL SL+AVW+GQKLDF K AH G APN+EV+ + + RILD + Sbjct: 58 DPPVCVSDSNKMFTLESLRAVWYGQKLDFLKSAHLGHAAPNTEVVLVEERKQVRILDCMK 117 Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTI 190 G RPL+LNFGSC+ PPFMAR++AFQR+V++Y DFL++YIEEAHPSDGWV +D+P+ I Sbjct: 118 GKRPLILNFGSCSUPPFMARLAAFQRVVSQYADIADFLVVYIEEAHPSDGWVNSDAPFQI 177 Query: 191 PQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRG 250 P+HR LEDR+ AA+++ PG +V+D M NSS++AYGAYFERLY+++ ++YQGGRG Sbjct: 178 PKHRCLEDRLRAAQLMLSEVPGGNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRG 237 Query: 251 PDGYQVSELRTWLEHYDEQL 270 P+GY++SELR WLE Y L Sbjct: 238 PEGYRISELRNWLEQYRNDL 257 >gb|ADC92287.1| type III iodothyronine deiodinase [Siganus guttatus] Length = 268 Score = 295 bits (755), Expect = 2e-96 Identities = 141/270 (52%), Positives = 192/270 (71%), Gaps = 13/270 (4%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M S + R A C +L PRF+ A MLWLLDFLC RK L + Sbjct: 2 MHDSCGVQKARALKHAALCGMLVPRFILAAVMLWLLDFLCSRKKVLVKM----------- 50 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 +G+++P DDPP+CVSD N++ T SL+AVW+GQKLDF K AH G APN+EV+ Sbjct: 51 -GKGQDIP-DDPPVCVSDSNKMFTSESLRAVWYGQKLDFLKSAHLGRAAPNTEVMLVQER 108 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 + RIL +G P++LNFGSC+ PPFM R++AFQR+V++Y DFL++YIEEAHPSDG Sbjct: 109 RQVRILVCMKGKSPVILNFGSCSUPPFMTRLAAFQRVVSQYADIADFLVVYIEEAHPSDG 168 Query: 181 WVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQS 240 WV+TD+PY IP+HR LEDR++AA+++ PGC +V+D+M NSS++AYGAYF+RLY++Q Sbjct: 169 WVSTDAPYQIPKHRCLEDRLNAAQLMHLEVPGCEVVVDSMENSSNAAYGAYFDRLYILQE 228 Query: 241 GTIMYQGGRGPDGYQVSELRTWLEHYDEQL 270 G I+YQGGRGP+GY+++EL+ WL+ Y + L Sbjct: 229 GKIVYQGGRGPEGYRITELKVWLDQYRKTL 258 >ref|NP_001129618.1| type III iodothyronine deiodinase a [Takifugu rubripes] dbj|BAG12773.1| iodothyronine deiodinase type III [Takifugu rubripes] Length = 268 Score = 291 bits (746), Expect = 4e-95 Identities = 142/250 (56%), Positives = 180/250 (72%), Gaps = 13/250 (5%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A CL+L PRFL TA MLWLLDF CIR+ L + P DDPP+CV Sbjct: 18 ALCLMLLPRFLLTAVMLWLLDFSCIRRKVLLQMGQRQKSP-------------DDPPVCV 64 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLV 136 SD NR+ TL SL AVW+GQKLDFFK AH G APN+EV+ + RILD +G RPL+ Sbjct: 65 SDSNRMFTLESLGAVWYGQKLDFFKSAHLGSAAPNTEVMLVQERRQVRILDCMKGKRPLI 124 Query: 137 LNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSL 196 LNFGSC+ PPFM R++AFQR+V +Y DFL++YIEEAHPSDGWV+TD+PY IP+HR L Sbjct: 125 LNFGSCSUPPFMTRLAAFQRVVQQYADIADFLVVYIEEAHPSDGWVSTDAPYQIPKHRCL 184 Query: 197 EDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 EDR+ AA+++ P +V+D M NSS++AYGAYFERLY+++ ++YQGGRGP+GY++ Sbjct: 185 EDRLRAAQLMLAEVPESNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRGPEGYRI 244 Query: 257 SELRTWLEHY 266 SELR+ LE Y Sbjct: 245 SELRSRLEQY 254 >ref|NP_001171406.2| type III iodothyronine deiodinase [Danio rerio] Length = 269 Score = 291 bits (746), Expect = 5e-95 Identities = 143/252 (56%), Positives = 185/252 (73%), Gaps = 14/252 (5%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A C++L PRFL A ML LLDFLCIR+ L + EG DDPP+ V Sbjct: 18 AVCVLLLPRFLLAALMLCLLDFLCIRRKLLLKMQ------------EGAFSSPDDPPLRV 65 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ--SQRILDYAQGSRP 134 SD N++ TL SL+AVW+GQKLDFFK A GG APN+EV DG ++RILDYA+G RP Sbjct: 66 SDSNKMFTLESLRAVWYGQKLDFFKSARLGGAAPNTEVFPLDGDARAAERILDYARGRRP 125 Query: 135 LVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHR 194 L+LNFGSC+ PPFM R+SAFQR+ +Y D L++YIEEAHPSDGWV++D+P IP+HR Sbjct: 126 LILNFGSCSUPPFMTRLSAFQRVARQYADIADSLLVYIEEAHPSDGWVSSDAPVQIPRHR 185 Query: 195 SLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGY 254 LEDR+ AA++L + A G A+V+D+M NS ++AYGAYFERLY+++ T++YQGGRGP+GY Sbjct: 186 CLEDRLRAAQMLHREAAGSAVVVDSMQNSCNAAYGAYFERLYIVKDATVVYQGGRGPEGY 245 Query: 255 QVSELRTWLEHY 266 +++ELR WLE Y Sbjct: 246 RIAELRDWLERY 257 >gb|ADD38971.1| deiodinase 3 [Danio rerio] Length = 269 Score = 288 bits (736), Expect = 1e-93 Identities = 141/252 (55%), Positives = 183/252 (72%), Gaps = 14/252 (5%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A C++L PRFL A ML LLDFLCIR+ L + EG DDPP+ V Sbjct: 18 AVCVLLLPRFLLAALMLCLLDFLCIRRKLLLKMQ------------EGAFSSPDDPPLRV 65 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ--SQRILDYAQGSRP 134 SD N++ TL SL+AVW+GQKLDFFK A GG APN+EV DG ++RILDYA+G RP Sbjct: 66 SDSNKMFTLESLRAVWYGQKLDFFKSARLGGAAPNTEVFPLDGDARAAERILDYARGRRP 125 Query: 135 LVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHR 194 L+LNFGSC+ PPFM R+SAFQR+ +Y D L++YIEEAHP DGWV++D+P IP+HR Sbjct: 126 LILNFGSCSUPPFMTRLSAFQRVARQYADIADSLLVYIEEAHPPDGWVSSDAPVQIPRHR 185 Query: 195 SLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGY 254 LEDR+ AA++L + A G A+V+D+M NS ++AYGAYFERLY+++ ++YQGGRGP+GY Sbjct: 186 CLEDRLRAAQMLHREAAGSAVVVDSMQNSCNAAYGAYFERLYIVKDAAVVYQGGRGPEGY 245 Query: 255 QVSELRTWLEHY 266 +++ELR WLE Y Sbjct: 246 RIAELRDWLERY 257 >ref|NP_001242932.1| type III iodothyronine deiodinase-like [Danio rerio] Length = 264 Score = 283 bits (723), Expect = 1e-91 Identities = 135/252 (53%), Positives = 187/252 (74%), Gaps = 7/252 (2%) Query: 19 CLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSD 78 CL++ PRFL AFMLW LDFLC+RK L H + E E E+ ++ P+C+SD Sbjct: 13 CLLILPRFLVAAFMLWCLDFLCVRKRVLV-----HLQERAE--EEEEDAEEEEEPLCISD 65 Query: 79 DNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLN 138 +R+ + SLKAV+HG KLD+ K A G AP+SEV + R+L++A+G RPLVL+ Sbjct: 66 SSRMFSWESLKAVFHGHKLDYMKSARLGHAAPDSEVFPLAEPRRGRVLEFARGHRPLVLS 125 Query: 139 FGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLED 198 FGSC+ PPFM R+ AF+RLV +Y D L+IYIEEAHPSDGW ++D+P+ I +HRSLE+ Sbjct: 126 FGSCSUPPFMRRLKAFRRLVLRYADVADALLIYIEEAHPSDGWRSSDAPHQIRRHRSLEE 185 Query: 199 RVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSE 258 R+SAAR++++ APGCA+V D M N+++SAYGAYF+RLY++Q G ++YQGGRGP+G+++SE Sbjct: 186 RLSAARLMEREAPGCAVVADGMENAANSAYGAYFDRLYIVQDGRVVYQGGRGPEGFRISE 245 Query: 259 LRTWLEHYDEQL 270 LR WL+ Y E+L Sbjct: 246 LRHWLDRYRERL 257 >gb|EHH28178.1| hypothetical protein EGK_18555 [Macaca mulatta] Length = 169 Score = 278 bits (712), Expect = 2e-91 Identities = 133/143 (93%), Positives = 135/143 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT 143 QSQRILDYAQG+RPLVLNFGSCT Sbjct: 147 QSQRILDYAQGNRPLVLNFGSCT 169 >gb|EAW81747.1| deiodinase, iodothyronine, type III [Homo sapiens] Length = 143 Score = 276 bits (707), Expect = 5e-91 Identities = 132/143 (92%), Positives = 134/143 (93%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 1 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 61 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT 143 QSQ ILDYAQG+RPLVLNFGSCT Sbjct: 121 QSQHILDYAQGNRPLVLNFGSCT 143 >ref|XP_003941651.1| PREDICTED: type III iodothyronine deiodinase [Saimiri boliviensis boliviensis] Length = 169 Score = 277 bits (709), Expect = 6e-91 Identities = 132/143 (92%), Positives = 135/143 (94%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEP+VEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPDVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT 143 QSQRILDYAQG+RPLVLNFGSCT Sbjct: 147 QSQRILDYAQGNRPLVLNFGSCT 169 >emb|CAD61926.1| unnamed protein product [Homo sapiens] Length = 169 Score = 276 bits (707), Expect = 1e-90 Identities = 132/143 (92%), Positives = 134/143 (93%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 27 MLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 86 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 87 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 146 Query: 121 QSQRILDYAQGSRPLVLNFGSCT 143 QSQ ILDYAQG+RPLVLNFGSCT Sbjct: 147 QSQHILDYAQGNRPLVLNFGSCT 169 >dbj|BAF84999.1| unnamed protein product [Homo sapiens] Length = 143 Score = 275 bits (703), Expect = 2e-90 Identities = 131/143 (91%), Positives = 133/143 (93%) Query: 1 MFRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVEL 60 M RSLLLHSLR CAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFL RR PEPEVEL Sbjct: 1 MLRSLLLHSLRFCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVEL 60 Query: 61 NSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 NSEGEEVP DDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEV+ PDGF Sbjct: 61 NSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF 120 Query: 121 QSQRILDYAQGSRPLVLNFGSCT 143 QSQ ILDYAQG+RPLVLNFGSCT Sbjct: 121 QSQHILDYAQGNRPLVLNFGSCT 143 >gb|ADC92286.2| type III iodothyronine deiodinase [Halichoeres trimaculatus] Length = 248 Score = 265 bits (676), Expect = 8e-85 Identities = 131/260 (50%), Positives = 170/260 (65%), Gaps = 33/260 (12%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPAD 70 R A CL+L PRF+ A MLWLLD LCIRK + + Sbjct: 12 RALKHAALCLMLMPRFVLAAVMLWLLDLLCIRKKVVVK---------------------- 49 Query: 71 DPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQ 130 + TL SL+AVW+GQKLDF K AH G APN+EV+ + RILD + Sbjct: 50 -----------MFTLESLRAVWYGQKLDFLKSAHLGSAAPNTEVMLVQERRQVRILDCMK 98 Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTI 190 G RPL+LNFGSC+ PPFM R++AFQR+V +Y+ DFL++YIEEAHPSDGWV+TD+PY I Sbjct: 99 GKRPLILNFGSCSUPPFMTRLAAFQRIVRQYEDIADFLVVYIEEAHPSDGWVSTDAPYQI 158 Query: 191 PQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRG 250 P+H+ LEDR+ AAR++ P +V+D M NSS++AYGAYFERLY+++ ++YQGGRG Sbjct: 159 PKHQCLEDRLRAARLMLAEVPSSNVVVDNMDNSSNAAYGAYFERLYIVRDERVVYQGGRG 218 Query: 251 PDGYQVSELRTWLEHYDEQL 270 P+GY++SELR WLE Y L Sbjct: 219 PEGYRISELRNWLEQYRNDL 238 >gb|AER97245.1| Type III iodothyronine deiodinase [Mustela putorius furo] Length = 133 Score = 258 bits (660), Expect = 5e-84 Identities = 123/132 (93%), Positives = 129/132 (97%) Query: 146 PFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARV 205 PFMARMSAF RLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPY+IPQHRSLEDRVSAA+V Sbjct: 1 PFMARMSAFHRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYSIPQHRSLEDRVSAAQV 60 Query: 206 LQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEH 265 LQQGAP C+LVLDTMANSSSSAYGAYFERLYVIQ+GTIMYQGGRGPDGYQVSELRTWLEH Sbjct: 61 LQQGAPSCSLVLDTMANSSSSAYGAYFERLYVIQNGTIMYQGGRGPDGYQVSELRTWLEH 120 Query: 266 YDEQLHGTRPRR 277 Y+EQLHG +PRR Sbjct: 121 YEEQLHGAQPRR 132 >gb|AEK78061.1| iodothyronine deiodinase type 3 [Scarus taeniopterus] Length = 201 Score = 249 bits (637), Expect = 1e-79 Identities = 121/214 (56%), Positives = 157/214 (73%), Gaps = 13/214 (6%) Query: 33 LWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDDNRLCTLASLKAVW 92 LWLLDFLCIRK L + EG++ P DDPP+CVSD N++ TL SL+AVW Sbjct: 1 LWLLDFLCIRKKVLLKM------------GEGQDSP-DDPPVCVSDSNKMFTLESLRAVW 47 Query: 93 HGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMS 152 +GQKLDF K AH G APN+EV+ + RILD +G RPL+LNFGSC+ PPFM R++ Sbjct: 48 YGQKLDFLKSAHLGRAAPNTEVMLLTDRRQVRILDCMKGKRPLILNFGSCSUPPFMTRLA 107 Query: 153 AFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPG 212 AFQR+V +YQ DFL++YIEEAHPSDGWV++D+PY IP+HR LEDR+ AAR++ PG Sbjct: 108 AFQRVVRQYQDIADFLVVYIEEAHPSDGWVSSDAPYQIPKHRCLEDRLRAARLMLAEVPG 167 Query: 213 CALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQ 246 +V+D M NSS++AYGAYFERLY+++ ++YQ Sbjct: 168 SNVVVDNMDNSSNAAYGAYFERLYILRDERVVYQ 201 >gb|ADC80775.1| iodothyronine deiodinase type III, partial [Gobiocypris rarus] Length = 201 Score = 244 bits (622), Expect = 2e-77 Identities = 121/210 (57%), Positives = 152/210 (72%), Gaps = 15/210 (7%) Query: 33 LWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDDNRLCTLASLKAVW 92 L LDFLCIR+ L + E + DDPP+CVSD NR+ TL SL+AVW Sbjct: 1 LLFLDFLCIRRKVLMKMR------------ESDVGSPDDPPMCVSDSNRMFTLESLRAVW 48 Query: 93 HGQKLDFFKQAHEGGPAPNSEVIRPDGFQ---SQRILDYAQGSRPLVLNFGSCT*PPFMA 149 +GQKLDFFK AH G APN+EV+ D +QRILDYA+G RPL+LNFGSC+ PPFM Sbjct: 49 YGQKLDFFKTAHLGDAAPNTEVVPLDSESRRGTQRILDYARGRRPLILNFGSCSUPPFMT 108 Query: 150 RMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQG 209 R+SAFQR+ +Y D L++YIEEAHPSDGWV++D+PY IP+HR LEDR+ AA ++ Q Sbjct: 109 RLSAFQRVARQYADIADSLLVYIEEAHPSDGWVSSDAPYQIPRHRCLEDRLRAAELMNQK 168 Query: 210 APGCALVLDTMANSSSSAYGAYFERLYVIQ 239 PG A+V+DTM NSS+SAYGAYFERLY+++ Sbjct: 169 VPGSAVVVDTMENSSNSAYGAYFERLYILK 198 >emb|CAG01826.1| unnamed protein product [Tetraodon nigroviridis] Length = 205 Score = 236 bits (603), Expect = 2e-74 Identities = 123/250 (49%), Positives = 158/250 (63%), Gaps = 46/250 (18%) Query: 17 ASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 A CL+L PRFL TA LWLLDFLCIR+ L L + ADDPP+CV Sbjct: 1 ALCLMLLPRFLLTAVALWLLDFLCIRRKVL-------------LQMGQRQKSADDPPVCV 47 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLV 136 SD N++ TL SL+AVW+GQKLDF K AH G APN+EV+ Q +R Sbjct: 48 SDSNKMFTLESLRAVWYGQKLDFLKSAHLGSAAPNTEVML---VQERR------------ 92 Query: 137 LNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSL 196 QR+V +Y DFL++YIEEAHPSDGWV+TD+P+ IP+HR L Sbjct: 93 ------------------QRIVRQYADIADFLVVYIEEAHPSDGWVSTDAPHQIPKHRCL 134 Query: 197 EDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 EDR+ AA+++ P +V+D M NSS++AYGAYFERLY+++ ++YQGGRGP+GY++ Sbjct: 135 EDRLRAAQLMLAEVPESNVVVDNMDNSSNAAYGAYFERLYILRDERVVYQGGRGPEGYRI 194 Query: 257 SELRTWLEHY 266 SELRTWLE Y Sbjct: 195 SELRTWLEQY 204 >gb|AFD01668.1| iodothyronine deiodinase type III, partial [Parus major] Length = 182 Score = 235 bits (600), Expect = 3e-74 Identities = 106/172 (61%), Positives = 139/172 (80%) Query: 99 FFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLV 158 FFK AH G APN EVI+ DG + RILD+A+G RPL+LNFGSCT PPFMAR+ +FQRL Sbjct: 1 FFKSAHVGSLAPNPEVIQLDGQKRLRILDFARGKRPLILNFGSCTUPPFMARLRSFQRLA 60 Query: 159 TKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLD 218 + DFL++YIEEAHPSDGWV++D+ Y IP+H+ L+DR+ AA+++++GAP C L +D Sbjct: 61 AHFVDIADFLLVYIEEAHPSDGWVSSDAAYNIPKHQCLQDRLRAAQLMREGAPDCPLAVD 120 Query: 219 TMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQL 270 TM N+SS+AYGAYFERLY+IQ +MYQGGRGP+GY++SELR+WL+ Y +L Sbjct: 121 TMDNASSAAYGAYFERLYIIQEEKVMYQGGRGPEGYKISELRSWLDQYKTRL 172 >gb|ABN54803.1| iodothyronine deiodinase type III [Sander vitreus] Length = 177 Score = 206 bits (524), Expect = 6e-63 Identities = 101/190 (53%), Positives = 132/190 (69%), Gaps = 13/190 (6%) Query: 39 LCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLD 98 LCIRK L + P DDPP+CVSD N++ TL SL+AVW+GQKLD Sbjct: 1 LCIRKKVLLKMKERQDSP-------------DDPPVCVSDSNKMFTLESLRAVWYGQKLD 47 Query: 99 FFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLV 158 F K AH G APN+EV+ + RILD +G RPL+LNFGSC+ PPFM R++AFQR+V Sbjct: 48 FLKSAHLGRAAPNTEVMMVQERRRVRILDCIKGKRPLILNFGSCSUPPFMTRLAAFQRVV 107 Query: 159 TKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLD 218 ++Y DFL++YIEEAHPSDGWV++D+PY IP+HR LEDR+ AA+++ PG +V+D Sbjct: 108 SQYLDIADFLVVYIEEAHPSDGWVSSDAPYQIPKHRCLEDRLRAAQLMLAQVPGSNVVVD 167 Query: 219 TMANSSSSAY 228 M NSS++AY Sbjct: 168 NMDNSSNAAY 177 >gb|ADI86261.1| iodothyronine deiodinase type 3 [Scarus iseri] Length = 159 Score = 196 bits (497), Expect = 4e-59 Identities = 92/154 (59%), Positives = 119/154 (77%), Gaps = 1/154 (0%) Query: 63 EGEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQS 122 EG++ P DDPP+CVSD N++ TL SL+AVW+GQKLDF K AH G APN+EV+ + Sbjct: 7 EGQDSP-DDPPVCVSDSNKMFTLESLRAVWYGQKLDFLKSAHLGRAAPNTEVMLLTDRRQ 65 Query: 123 QRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWV 182 RILD +G RPL+LNFGSC+ PPFM R++AFQR+V +YQ DFL++YIEEAHPSDGWV Sbjct: 66 VRILDCMKGKRPLILNFGSCSUPPFMTRLAAFQRVVRQYQDIADFLVVYIEEAHPSDGWV 125 Query: 183 TTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALV 216 ++D+PY IP+HR LEDR+ AAR++ PG +V Sbjct: 126 SSDAPYQIPKHRCLEDRLRAARLMLAEVPGSNVV 159 >gb|ACJ03410.1| type III iodothyronine deiodinase [Phodopus sungorus] Length = 83 Score = 178 bits (452), Expect = 2e-53 Identities = 81/83 (97%), Positives = 83/83 (100%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPAD 70 R+CAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVP+D Sbjct: 1 RVCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPSD 60 Query: 71 DPPICVSDDNRLCTLASLKAVWH 93 DPPICVSDDNRLCTLASLKAVWH Sbjct: 61 DPPICVSDDNRLCTLASLKAVWH 83 >gb|AEH68217.1| type III iodothyronine deiodinase, partial [Engystomops pustulosus] Length = 129 Score = 178 bits (451), Expect = 1e-52 Identities = 82/129 (63%), Positives = 106/129 (82%) Query: 82 LCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGS 141 +CTL SLKAVWHGQKLD+FK AH G APN+EV+ +G + RILD++QG RPLV+NFGS Sbjct: 1 MCTLESLKAVWHGQKLDYFKSAHLGCSAPNTEVVMLEGQRLCRILDFSQGHRPLVVNFGS 60 Query: 142 CT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVS 201 CT PPFMAR+ A+ RL +++ DFL++YIEEAHPSDGWV+TD+ Y IP+H+SL+DRV Sbjct: 61 CTUPPFMARLQAYHRLASQHIDIADFLLVYIEEAHPSDGWVSTDASYQIPKHQSLQDRVR 120 Query: 202 AARVLQQGA 210 AA+++ QGA Sbjct: 121 AAQLMLQGA 129 >gb|AAI06401.1| Dio3 protein [Xenopus laevis] Length = 136 Score = 177 bits (449), Expect = 3e-52 Identities = 76/127 (59%), Positives = 106/127 (83%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 MAR+ A++RL ++ DFL++YIEEAHPSDGW++TD+ Y IPQH+ L+DR++AA+++ Sbjct: 1 MARLQAYRRLAAQHVGIADFLLVYIEEAHPSDGWLSTDASYQIPQHQCLQDRLAAAQLML 60 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYD 267 QGAPGC +V+DTM NSS++AYGAYFERLY++ G ++YQGGRGP+GY++SELR WLE Y Sbjct: 61 QGAPGCRVVVDTMDNSSNAAYGAYFERLYIVLEGKVVYQGGRGPEGYKISELRMWLEQYQ 120 Query: 268 EQLHGTR 274 + L GT+ Sbjct: 121 QGLMGTK 127 >ref|NP_001087559.1| MGC84484 protein [Xenopus laevis] gb|AAH80103.1| MGC84484 protein [Xenopus laevis] Length = 134 Score = 174 bits (441), Expect = 4e-51 Identities = 74/123 (60%), Positives = 103/123 (83%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 MAR+ A+ RLV ++ DFL++YIEEAHP+DGW++TD+ Y IPQHR L++R++AA+++ Sbjct: 1 MARLQAYSRLVAQHVAIADFLLVYIEEAHPTDGWISTDASYQIPQHRCLQERLAAAQLML 60 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYD 267 QGAPGC +V DTM NSS++AYGAYFERLY+I G ++YQGGRGP+GY++SELR WLE Y Sbjct: 61 QGAPGCRVVADTMDNSSNAAYGAYFERLYIILEGKVVYQGGRGPEGYKISELRLWLERYQ 120 Query: 268 EQL 270 +++ Sbjct: 121 QRI 123 >gb|AAI57249.1| dio3 protein [Xenopus (Silurana) tropicalis] Length = 136 Score = 174 bits (441), Expect = 5e-51 Identities = 76/126 (60%), Positives = 102/126 (80%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 MAR+ A++RL ++ DFL++YIEEAHPSDGWV+TD+ Y IPQH+ L+DR++AA+++ Sbjct: 1 MARLQAYRRLAAQHVGTADFLLVYIEEAHPSDGWVSTDASYQIPQHQCLQDRLAAAQLML 60 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYD 267 QG PGC +V DTM NSS++AYGAYFERLY+I G ++YQGGRGP+GY++SELR WLE Y Sbjct: 61 QGVPGCRVVADTMDNSSNAAYGAYFERLYIILEGKVVYQGGRGPEGYKISELRMWLEQYQ 120 Query: 268 EQLHGT 273 + GT Sbjct: 121 QGTIGT 126 >sp|O42449|IOD1_ORENI RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase Length = 248 Score = 162 bits (410), Expect = 5e-45 Identities = 99/251 (39%), Positives = 145/251 (57%), Gaps = 20/251 (7%) Query: 18 SCLVLFPRFLGTAFMLWLLDFLC--IRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPIC 75 S +F LG ML +L F + K F+ R GE++ P Sbjct: 11 STACMFCYMLGKFLMLVILQFFSPSLAKKFILRM--------------GEKITMTQNPRF 56 Query: 76 VSDDNRLC--TLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 +D L +LA +K L ++A GG AP+S V+ D + I Y +G+R Sbjct: 57 NYEDWGLTFMSLAFIKTASSHMWLSLGEEAFVGGEAPDSPVVTMDR-EKTSISKYLKGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVL+FGSCT PPFM ++ F++LV + DFL+IYI EAH +DGW ++ Y I QH Sbjct: 116 PLVLSFGSCTUPPFMYKLDEFKQLVKDFSDVADFLVIYIAEAHSTDGWAFKNN-YDINQH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 +SLEDR+SAA+VL Q P C +V+D M + ++ YGA ERL+++Q+G ++Y+GG+GP G Sbjct: 175 QSLEDRLSAAQVLVQSEPLCPVVVDEMTDVTTIKYGALPERLFILQAGKVLYKGGKGPWG 234 Query: 254 YQVSELRTWLE 264 Y +E+R++LE Sbjct: 235 YNPAEVRSFLE 245 >ref|XP_003439849.1| PREDICTED: LOW QUALITY PROTEIN: type I iodothyronine deiodinase [Oreochromis niloticus] emb|CAA71995.1| Type I iodothyronine deiodinase [Oreochromis niloticus] Length = 248 Score = 162 bits (410), Expect = 5e-45 Identities = 99/251 (39%), Positives = 145/251 (57%), Gaps = 20/251 (7%) Query: 18 SCLVLFPRFLGTAFMLWLLDFLC--IRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPIC 75 S +F LG ML +L F + K F+ R GE++ P Sbjct: 11 STACMFCYMLGKFLMLVILQFFSPSLAKKFILRM--------------GEKITMTQNPRF 56 Query: 76 VSDDNRLC--TLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 +D L +LA +K L ++A GG AP+S V+ D + I Y +G+R Sbjct: 57 NYEDWGLTFMSLAFIKTASSHMWLSLGEEAFVGGEAPDSPVVTMDR-EKTSISKYLKGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVL+FGSCT PPFM ++ F++LV + DFL+IYI EAH +DGW ++ Y I QH Sbjct: 116 PLVLSFGSCTXPPFMYKLDEFKQLVKDFSDVADFLVIYIAEAHSTDGWAFKNN-YDINQH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 +SLEDR+SAA+VL Q P C +V+D M + ++ YGA ERL+++Q+G ++Y+GG+GP G Sbjct: 175 QSLEDRLSAAQVLVQSEPLCPVVVDEMTDVTTIKYGALPERLFILQAGKVLYKGGKGPWG 234 Query: 254 YQVSELRTWLE 264 Y +E+R++LE Sbjct: 235 YNPAEVRSFLE 245 >sp|P49896|IOD2_RANCA RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAC42231.2| iodothyronine deiodinase type II [Rana catesbeiana] Length = 264 Score = 162 bits (411), Expect = 5e-45 Identities = 96/257 (37%), Positives = 141/257 (54%), Gaps = 32/257 (12%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDD 79 L + P F L L D + + KH L + + +S G+ Sbjct: 12 LQILPGFFSNCLFLALYDSVVLVKHVLLQLNRSK-------SSHGQW------------- 51 Query: 80 NRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQ--------RILDYAQG 131 R+ T L+ VW+ LD +KQ GG APNS VI S +LD+A Sbjct: 52 RRMLTPEGLRCVWNSFLLDAYKQVKLGGDAPNSNVIHVTDKNSSSGKPGTPCHLLDFASS 111 Query: 132 SRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTD-SPYTI 190 RPLV+NFGS T PPF++++ AF ++V ++ DFL++YI+EAHPSDGW S Y + Sbjct: 112 ERPLVVNFGSATUPPFISQLPAFSKMVEEFSAVADFLLVYIDEAHPSDGWAAPGISSYEV 171 Query: 191 PQHRSLEDRVSAA-RVLQQGA--PGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQG 247 +HR+ EDR +AA ++L+Q + P C +V D M N++++AYG FER+ ++Q I+Y G Sbjct: 172 KKHRNQEDRCAAANKLLEQYSLPPQCQVVADCMDNNTNAAYGVSFERVCIVQRQKIVYLG 231 Query: 248 GRGPDGYQVSELRTWLE 264 G+GP Y + E+R WLE Sbjct: 232 GKGPFFYNLQEVRQWLE 248 >sp|O42411|IOD1_CHICK RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase Length = 245 Score = 161 bits (408), Expect = 8e-45 Identities = 83/163 (50%), Positives = 108/163 (66%), Gaps = 2/163 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +AHEG PAPN+ V+ +G + Q + + + +RPL+LNFGSCT P FM + F +LV + Sbjct: 82 EAHEGRPAPNTPVVALNG-EMQHLFSFMRDNRPLILNFGSCTUPSFMLKFDEFNKLVKDF 140 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMA 221 DFLIIYIEEAH DGW ++ I HRSLEDR +AA+ LQQ P C +VLDTM Sbjct: 141 SSIADFLIIYIEEAHAVDGWAFRNN-VVIKNHRSLEDRKTAAQFLQQKNPLCPVVLDTME 199 Query: 222 NSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 N SSS Y A ERLY++Q+G ++Y+GG GP Y E+R LE Sbjct: 200 NLSSSKYAALPERLYILQAGNVIYKGGVGPWNYHPQEIRAVLE 242 >emb|CAA71996.1| Type I iodothyronine deiodinase [Gallus gallus] Length = 245 Score = 161 bits (408), Expect = 8e-45 Identities = 83/163 (50%), Positives = 108/163 (66%), Gaps = 2/163 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +AHEG PAPN+ V+ +G + Q + + + +RPL+LNFGSCT P FM + F +LV + Sbjct: 82 EAHEGRPAPNTPVVALNG-EMQHLFSFMRDNRPLILNFGSCTXPSFMLKFDEFNKLVKDF 140 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMA 221 DFLIIYIEEAH DGW ++ I HRSLEDR +AA+ LQQ P C +VLDTM Sbjct: 141 SSIADFLIIYIEEAHAVDGWAFRNN-VVIKNHRSLEDRKTAAQFLQQKNPLCPVVLDTME 199 Query: 222 NSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 N SSS Y A ERLY++Q+G ++Y+GG GP Y E+R LE Sbjct: 200 NLSSSKYAALPERLYILQAGNVIYKGGVGPWNYHPQEIRAVLE 242 >ref|NP_001091083.1| type I iodothyronine deiodinase [Gallus gallus] Length = 246 Score = 161 bits (408), Expect = 9e-45 Identities = 83/163 (50%), Positives = 108/163 (66%), Gaps = 2/163 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +AHEG PAPN+ V+ +G + Q + + + +RPL+LNFGSCT P FM + F +LV + Sbjct: 83 EAHEGRPAPNTPVVALNG-EMQHLFSFMRDNRPLILNFGSCTUPSFMLKFDEFNKLVKDF 141 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMA 221 DFLIIYIEEAH DGW ++ I HRSLEDR +AA+ LQQ P C +VLDTM Sbjct: 142 SSIADFLIIYIEEAHAVDGWAFRNN-VVIKNHRSLEDRKTAAQFLQQKNPLCPVVLDTME 200 Query: 222 NSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 N SSS Y A ERLY++Q+G ++Y+GG GP Y E+R LE Sbjct: 201 NLSSSKYAALPERLYILQAGNVIYKGGVGPWNYHPQEIRAVLE 243 >ref|XP_003793192.1| PREDICTED: type I iodothyronine deiodinase [Otolemur garnettii] Length = 249 Score = 160 bits (404), Expect = 4e-44 Identities = 90/194 (46%), Positives = 117/194 (60%), Gaps = 5/194 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + GG APN V+R G Q I D+ QG+R Sbjct: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDMTERGGLAPNCPVVRLSG-QKCNIWDFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RLV + DFLIIYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTXPSFLFKFDQFKRLVEDFSSVADFLIIYIEEAHASDGWAFKNN-VDIRTH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYV+Q G I+Y+G GP Sbjct: 175 QNLQDRLQAAHLLLARSPQCPVVVDTMENQSSQLYAALPERLYVLQEGRILYKGKSGPWN 234 Query: 254 YQVSELRTWLEHYD 267 YQ E+R LE +D Sbjct: 235 YQPEEVRAVLEKFD 248 >gb|ACB59241.1| type 2 iodothyronine 5'-deiodinase [Coturnix japonica] Length = 252 Score = 160 bits (404), Expect = 4e-44 Identities = 102/270 (37%), Positives = 137/270 (50%), Gaps = 48/270 (17%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 L + P F L L D + + KH FL R E L SEG Sbjct: 4 LQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEG------------ 51 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR----PDGFQSQ--------- 123 L+ VW+ LD +KQ GG APNS VI DG S Sbjct: 52 -----------LRCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKDNDGSSSGWKSVGGKCG 100 Query: 124 ---RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 R+LD+A RPLV+NFGS T PPF +++SAF +LV ++ DFL++YI+EAHPSDG Sbjct: 101 TKCRLLDFANSERPLVVNFGSATUPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDG 160 Query: 181 WVT---TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFER 234 W + S + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER Sbjct: 161 WAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFER 220 Query: 235 LYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + ++Q I Y GG+GP Y + E+R WLE Sbjct: 221 VCIVQRQKIAYLGGKGPFFYNLQEVRLWLE 250 >ref|NP_067685.5| type I iodothyronine deiodinase [Rattus norvegicus] sp|P24389|IOD1_RAT RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|AAH83557.1| Deiodinase, iodothyronine, type I [Rattus norvegicus] Length = 257 Score = 160 bits (404), Expect = 4e-44 Identities = 91/189 (48%), Positives = 116/189 (61%), Gaps = 5/189 (2%) Query: 79 DNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPL 135 DN + T S++ W K+ + + +A GG APN V+R G Q + D+ QGSRPL Sbjct: 59 DNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSG-QKCNVWDFIQGSRPL 117 Query: 136 VLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRS 195 VLNFGSCT P F+ + F+RLV + DFLIIYIEEAH +DGW ++ I QHRS Sbjct: 118 VLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNN-VDIRQHRS 176 Query: 196 LEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQ 255 L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVIQ G I Y+G GP Y Sbjct: 177 LQDRLRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKPGPWNYN 236 Query: 256 VSELRTWLE 264 E+R LE Sbjct: 237 PEEVRAVLE 245 >emb|CAA41063.1| thyroxine deiodinase [Rattus norvegicus] Length = 257 Score = 160 bits (404), Expect = 4e-44 Identities = 91/189 (48%), Positives = 116/189 (61%), Gaps = 5/189 (2%) Query: 79 DNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPL 135 DN + T S++ W K+ + + +A GG APN V+R G Q + D+ QGSRPL Sbjct: 59 DNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSG-QKCNVWDFIQGSRPL 117 Query: 136 VLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRS 195 VLNFGSCT P F+ + F+RLV + DFLIIYIEEAH +DGW ++ I QHRS Sbjct: 118 VLNFGSCTXPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNN-VDIRQHRS 176 Query: 196 LEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQ 255 L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVIQ G I Y+G GP Y Sbjct: 177 LQDRLRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKPGPWNYN 236 Query: 256 VSELRTWLE 264 E+R LE Sbjct: 237 PEEVRAVLE 245 >gb|AAK40121.1| type II deodinase [Xenopus laevis] Length = 262 Score = 160 bits (404), Expect = 5e-44 Identities = 96/269 (35%), Positives = 139/269 (51%), Gaps = 35/269 (13%) Query: 11 RLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPAD 70 RL L + P F L L D + + KH L ++LN Sbjct: 8 RLSVDLLITLQILPGFFSNCLFLALYDSVVLVKHVL-----------LQLNRSKSSQ--- 53 Query: 71 DPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQR------ 124 S R+ T L+ VW+ LD +KQ G APNS VI+ ++ + Sbjct: 54 ------SQWRRMLTPEGLRCVWNSFLLDAYKQVKLGQDAPNSNVIQVSNNRTSKSVQRKF 107 Query: 125 -----ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSD 179 +LD+A RPLV+NFGS T PPF++++ AF +LV ++ DF+++YI+EAHPSD Sbjct: 108 AGKCHLLDFASSERPLVVNFGSATUPPFISQLPAFSKLVEEFSSVADFVLVYIDEAHPSD 167 Query: 180 GWVTT-DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERL 235 GW + Y + +HRS E+R +AA L Q P C +V D M N+++ AYG FER+ Sbjct: 168 GWAAPGTASYEVKKHRSQEERCAAASKLLQHFSIPPQCQVVADCMDNNANVAYGVSFERV 227 Query: 236 YVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 ++Q I+Y GG+GP Y + E+R WLE Sbjct: 228 CIVQRQKIVYLGGKGPFFYNIQEIRRWLE 256 >gb|ABI93489.1| iodothyronine deiodinase type III [Hippoglossus hippoglossus] Length = 125 Score = 155 bits (392), Expect = 7e-44 Identities = 65/105 (61%), Positives = 91/105 (86%) Query: 166 DFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSS 225 D +++YIEEAHPSDGW++TD+PY IP+HR LEDR++AA++++ PGC LV+D+M NSS+ Sbjct: 11 DSVVVYIEEAHPSDGWMSTDAPYQIPKHRCLEDRLNAAQLMRLEVPGCLLVVDSMENSSN 70 Query: 226 SAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQL 270 +AYGAYF+RLY++Q G I+YQGGRGP+GY++SELR WL+ Y +L Sbjct: 71 AAYGAYFDRLYILQEGKIVYQGGRGPEGYRISELRDWLDQYRGRL 115 >sp|Q9IAX2|IOD2_CHICK RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAD33251.1|AF125575_1 type 2 iodothyronine 5'-deiodinase [Gallus gallus] Length = 279 Score = 159 bits (403), Expect = 1e-43 Identities = 103/278 (37%), Positives = 138/278 (49%), Gaps = 48/278 (17%) Query: 12 LCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEVP 68 L A L + P F L L D + + KH FL R E L SEG Sbjct: 4 LSADLLITLQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEG---- 59 Query: 69 ADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR----PDGFQSQ- 123 L+ VW+ LD +KQ GG APNS VI DG S Sbjct: 60 -------------------LRCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKGNDGSNSSW 100 Query: 124 -----------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYI 172 +LD+A RPLV+NFGS T PPF +++SAF +LV ++ DFL++YI Sbjct: 101 KSVGGKCGTKCHLLDFANSERPLVVNFGSATUPPFTSQLSAFSKLVEEFSGVADFLLVYI 160 Query: 173 EEAHPSDGWVT---TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSS 226 +EAHPSDGW + S + + +HR+ EDR +AA L + P C +V D M N+++ Sbjct: 161 DEAHPSDGWAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANV 220 Query: 227 AYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 221 AYGVSFERVCIVQRQKIAYLGGKGPFFYNLQEVRLWLE 258 >ref|NP_001243688.1| type I iodothyronine deiodinase [Cricetulus griseus] Length = 257 Score = 159 bits (401), Expect = 1e-43 Identities = 91/191 (47%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S++ W K+ + + +A GG APN V+R G Q I D+ QG+R Sbjct: 57 SPDNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSG-QKCNIWDFIQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RLV + DFL+IYIEEAH +DGW ++ I QH Sbjct: 116 PLVLNFGSCTUPSFLFKFDQFKRLVDDFASTADFLVIYIEEAHATDGWAFKNN-VDIRQH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 RSL+DR+ AA +L P C +V+DTM N SS Y A ERLYVIQ G I Y+G GP Sbjct: 175 RSLQDRLQAAHLLLARNPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKPGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YNPEEVRAVLE 245 >sp|Q61153|IOD1_MOUSE RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase Length = 257 Score = 159 bits (401), Expect = 1e-43 Identities = 92/189 (48%), Positives = 116/189 (61%), Gaps = 5/189 (2%) Query: 79 DNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPL 135 DN + T S++ W K+ + + +A GG APN V+ G Q I D+ QGSRPL Sbjct: 59 DNWVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSG-QKCNIWDFIQGSRPL 117 Query: 136 VLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRS 195 VLNFGSCT P F+ + F+RLV + DFLIIYIEEAH +DGW ++ I QHRS Sbjct: 118 VLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNN-VDIRQHRS 176 Query: 196 LEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQ 255 L++RV AAR+L +P C +V+DTM N SS Y A ERLYVIQ G I Y+G GP Y Sbjct: 177 LQERVRAARLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKAGPWNYN 236 Query: 256 VSELRTWLE 264 E+R LE Sbjct: 237 PEEVRAVLE 245 >gb|AAH19786.1| Deiodinase, iodothyronine, type I [Mus musculus] Length = 257 Score = 159 bits (401), Expect = 1e-43 Identities = 92/189 (48%), Positives = 116/189 (61%), Gaps = 5/189 (2%) Query: 79 DNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPL 135 DN + T S++ W K+ + + +A GG APN V+ G Q I D+ QGSRPL Sbjct: 59 DNWVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSG-QKCNIWDFIQGSRPL 117 Query: 136 VLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRS 195 VLNFGSCT P F+ + F+RLV + DFLIIYIEEAH +DGW ++ I QHRS Sbjct: 118 VLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNN-VDIRQHRS 176 Query: 196 LEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQ 255 L++RV AAR+L +P C +V+DTM N SS Y A ERLYVIQ G I Y+G GP Y Sbjct: 177 LQERVRAARLLLARSPRCPVVVDTMQNQSSQLYAALPERLYVIQEGRIRYKGKAGPWNYN 236 Query: 256 VSELRTWLE 264 E+R LE Sbjct: 237 PEEVRAVLE 245 >ref|NP_031886.3| type I iodothyronine deiodinase [Mus musculus] gb|AAH89608.1| Deiodinase, iodothyronine, type I [Mus musculus] Length = 257 Score = 159 bits (401), Expect = 1e-43 Identities = 92/189 (48%), Positives = 116/189 (61%), Gaps = 5/189 (2%) Query: 79 DNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPL 135 DN + T S++ W K+ + + +A GG APN V+ G Q I D+ QGSRPL Sbjct: 59 DNWVPTFFSIQYFWFVLKVRWQRLEDRAEFGGLAPNCTVVCLSG-QKCNIWDFIQGSRPL 117 Query: 136 VLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRS 195 VLNFGSCT P F+ + F+RLV + DFLIIYIEEAH +DGW ++ I QHRS Sbjct: 118 VLNFGSCTUPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNN-VDIRQHRS 176 Query: 196 LEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQ 255 L++RV AAR+L +P C +V+DTM N SS Y A ERLYVIQ G I Y+G GP Y Sbjct: 177 LQERVRAARMLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKAGPWNYN 236 Query: 256 VSELRTWLE 264 E+R LE Sbjct: 237 PEEVRAVLE 245 >ref|XP_003208923.1| PREDICTED: LOW QUALITY PROTEIN: type I iodothyronine deiodinase-like [Meleagris gallopavo] Length = 246 Score = 158 bits (400), Expect = 1e-43 Identities = 82/163 (50%), Positives = 110/163 (67%), Gaps = 2/163 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +A+EG PAPN+ V+ +G + +++ + + +RPL+LNFGSCT P FM + F +LV + Sbjct: 83 KAYEGHPAPNTPVVALNG-EIRQLSSFMRDNRPLILNFGSCTXPSFMLKFDEFNKLVKDF 141 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMA 221 DFLIIYIEEAH DGW ++ I HRSLEDR +AA+ LQQ P C +VLDTM Sbjct: 142 SSVADFLIIYIEEAHAVDGWAFKNN-VVIKNHRSLEDRKTAAQFLQQKNPLCPVVLDTME 200 Query: 222 NSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 N SSS Y A ERLY++Q+G ++Y+GG GP Y E+RT LE Sbjct: 201 NLSSSQYAALPERLYILQAGNVIYKGGVGPWNYHPQEIRTVLE 243 >ref|NP_989445.2| type II iodothyronine deiodinase [Gallus gallus] Length = 279 Score = 159 bits (401), Expect = 2e-43 Identities = 101/270 (37%), Positives = 136/270 (50%), Gaps = 48/270 (17%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 L + P F L L D + + KH FL R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEG------------ 59 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR----PDGFQSQ--------- 123 L+ VW+ LD +KQ GG APNS VI DG S Sbjct: 60 -----------LRCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKGNDGSNSSWKSVGGKCG 108 Query: 124 ---RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 +LD+A RPLV+NFGS T PPF +++SAF +LV ++ DFL++YI+EAHPSDG Sbjct: 109 TKCHLLDFANSERPLVVNFGSATUPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDG 168 Query: 181 WVT---TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFER 234 W + S + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER Sbjct: 169 WAAPGISPSSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVSFER 228 Query: 235 LYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + ++Q I Y GG+GP Y + E+R WLE Sbjct: 229 VCIVQRQKIAYLGGKGPFFYNLQEVRLWLE 258 >sp|Q804E1|IOD1_FUNHE RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|AAO31952.1| deiodinase type I [Fundulus heteroclitus] Length = 248 Score = 157 bits (397), Expect = 4e-43 Identities = 88/203 (43%), Positives = 128/203 (63%), Gaps = 4/203 (1%) Query: 64 GEEVPADDPPICVSDDNRLC--TLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ 121 GE+V P +D L +LA +K L ++A G AP+S V+ DG + Sbjct: 45 GEKVTMTQNPKFSYEDWGLTYGSLAFIKVASQTMWLSLGQEAFVGEDAPDSPVVTVDGER 104 Query: 122 SQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW 181 + I +Y +G+RPLVL+FGSCT PPFM ++ F++LV + DFL++Y+ EAH +DGW Sbjct: 105 TS-ICNYLKGNRPLVLSFGSCTUPPFMFKLGEFKQLVRDFVDVADFLVVYVAEAHSTDGW 163 Query: 182 VTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSG 241 + + + I QHRSLEDR+SAAR+L Q P C +V+D M+N S+ Y A ERLYV+Q+G Sbjct: 164 -SFGNNFDIRQHRSLEDRLSAARILVQNDPLCPVVVDEMSNVSAIKYAAQPERLYVLQAG 222 Query: 242 TIMYQGGRGPDGYQVSELRTWLE 264 ++Y+G GP GY E+R+ L+ Sbjct: 223 KVLYKGAMGPWGYNPQEVRSVLQ 245 >gb|ABI93488.1| iodothyronine deiodinase type I [Hippoglossus hippoglossus] Length = 204 Score = 155 bits (393), Expect = 5e-43 Identities = 79/168 (47%), Positives = 117/168 (69%), Gaps = 2/168 (1%) Query: 97 LDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQR 156 L ++A GG AP+S V+ +G +S + + +G+RPLVL+FGSCT PPF+ ++ F++ Sbjct: 36 LSLGQEAFVGGEAPDSPVVTMEGEKSS-LCKFIKGNRPLVLSFGSCTUPPFIYKLDEFKQ 94 Query: 157 LVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALV 216 LV + DFL++YI EAH +DGW T++ Y I QHRSLE+R+SAAR+L Q P C +V Sbjct: 95 LVRDFGDVADFLVVYIAEAHSTDGWAFTNN-YDINQHRSLEERLSAARILVQQEPLCPVV 153 Query: 217 LDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 +D M + ++ YGA ERLYV+Q+G ++Y+GG GP Y S++R +LE Sbjct: 154 VDEMNDVAAIKYGALPERLYVLQAGKVIYEGGMGPWDYNPSDVRLFLE 201 >ref|NP_001007127.1| type I iodothyronine deiodinase [Canis lupus familiaris] sp|P49894|IOD1_CANFA RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|AAA53207.2| type I iodothyronine deiodinase [Canis lupus familiaris] Length = 244 Score = 157 bits (396), Expect = 5e-43 Identities = 89/191 (46%), Positives = 117/191 (61%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN TL S++ W K+ + + + GG APN V+R G Q I D+ QG+R Sbjct: 52 SYDNWAPTLYSMQYFWFVLKVQWQRLEDRTEPGGLAPNCPVVRLSG-QRCNIWDFMQGNR 110 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RL+ + DFLIIYIEEAH SDGW ++ I H Sbjct: 111 PLVLNFGSCTUPSFLFKFDQFKRLIEDFCSTADFLIIYIEEAHASDGWAFKNN-VNIRTH 169 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AAR+L AP C +V+DTM N SS Y A ERL+V+Q G I+Y+G GP Sbjct: 170 QTLQDRLQAARLLLDRAPPCPVVVDTMRNQSSQFYAALPERLFVLQEGRILYKGKPGPWN 229 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 230 YHPEEVRAVLE 240 >ref|XP_003206693.1| PREDICTED: LOW QUALITY PROTEIN: type II iodothyronine deiodinase-like [Meleagris gallopavo] Length = 264 Score = 157 bits (397), Expect = 6e-43 Identities = 101/270 (37%), Positives = 136/270 (50%), Gaps = 48/270 (17%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 L + P F L L D + + KH FL R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSARGEWRRMLTSEG------------ 59 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR----PDGFQSQ--------- 123 L+ VW+ LD +KQ GG APNS VI DG S Sbjct: 60 -----------LRCVWNSFLLDAYKQVKLGGEAPNSSVIHIANGNDGSGSSWKSVGGKCG 108 Query: 124 ---RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 +LD+A RPLV+NFGS T PPF +++SAF +LV ++ DFL++YI+EAHPSDG Sbjct: 109 TKCHLLDFANSERPLVVNFGSATXPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDG 168 Query: 181 WVT---TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFER 234 W + S + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER Sbjct: 169 WAAPGISPSSFEVKKHRNQEDRCAAAYQLLERFSLPPQCQVVADCMDNNANVAYGVSFER 228 Query: 235 LYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + ++Q I Y GG+GP Y + E+R WLE Sbjct: 229 VCIVQRQKIAYLGGKGPFFYNLQEVRLWLE 258 >ref|NP_001116124.1| type I iodothyronine deiodinase [Macaca mulatta] Length = 249 Score = 156 bits (395), Expect = 8e-43 Identities = 90/191 (47%), Positives = 114/191 (59%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + GG APN V+R G Q I D+ QG+R Sbjct: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSG-QRCNIWDFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P FM + F+RL+ + DFLIIYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLIIYIEEAHASDGWAFKNN-MDIRNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 R+L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVIQ G I+Y+G GP Sbjct: 175 RNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRILYKGKSGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YNPEEVRAVLE 245 >dbj|BAG15906.1| iodothyronine deiodinase type I [Paralichthys olivaceus] Length = 248 Score = 156 bits (394), Expect = 1e-42 Identities = 79/168 (47%), Positives = 117/168 (69%), Gaps = 2/168 (1%) Query: 97 LDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQR 156 L ++A GG AP+S V+ +G +S + + +GSRPLVL+FGSCT PPF+ ++ F++ Sbjct: 80 LSLGQEAFVGGEAPDSPVVTMEGKKSS-VCKFIRGSRPLVLSFGSCTUPPFIYKLDEFKQ 138 Query: 157 LVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALV 216 LV + DF+++YI EAH +DGW T++ + I QHRSLE+R+SAA++L Q P C +V Sbjct: 139 LVRDFSDVADFMVVYIAEAHSTDGWAFTNN-FDINQHRSLEERLSAAQILVQQEPLCPVV 197 Query: 217 LDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 +D M + S+ YGA ERLYV+Q+G ++Y+GG GP GY E+R+ LE Sbjct: 198 VDEMNDVSAIKYGALPERLYVLQAGKVIYKGGMGPWGYNPLEVRSLLE 245 >ref|NP_001159924.1| deiodinase, iodothyronine, type I [Equus caballus] Length = 244 Score = 155 bits (393), Expect = 1e-42 Identities = 90/193 (46%), Positives = 118/193 (61%), Gaps = 9/193 (4%) Query: 77 SDDNRLCTLASLKAVW-----HGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQG 131 S DN + TL S + W H Q+L+ GG APNS V+R G Q I D+ QG Sbjct: 52 SYDNWVPTLYSTQYFWFVLKVHWQRLE--DTTKRGGLAPNSPVVRLSG-QRCNIWDFMQG 108 Query: 132 SRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIP 191 +RPLVLNFGSCT P F+ + F+RL+ + DFLIIYIEEAH SDGW ++ I Sbjct: 109 NRPLVLNFGSCTUPSFLFKFDQFKRLIEDFSSIADFLIIYIEEAHASDGWAFKNN-VVIR 167 Query: 192 QHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGP 251 HR+L+DR+ AAR+L +P C +V+D+M N SS Y A +RLYV+Q+ I+Y+G GP Sbjct: 168 NHRNLQDRLRAARLLLDRSPPCPVVVDSMENRSSQLYAALPDRLYVLQARRILYKGKPGP 227 Query: 252 DGYQVSELRTWLE 264 Y E+R LE Sbjct: 228 WNYHPEEVRAVLE 240 >ref|NP_001257898.1| deiodinase, iodothyronine, type II [Taeniopygia guttata] Length = 279 Score = 156 bits (395), Expect = 2e-42 Identities = 99/270 (36%), Positives = 135/270 (50%), Gaps = 48/270 (17%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 L + P F L L D + + KH FL R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSGRGEWRRMLTSEG------------ 59 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR----PDGFQSQ--------- 123 L+ VW+ LD +KQ GG APNS VI DG Sbjct: 60 -----------LRCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKGSDGSSGSWKNVGGKCG 108 Query: 124 ---RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 +LD+A RPLV+NFGS T PPF +++SAF +LV ++ DFL++YI+EAHPSDG Sbjct: 109 TKCHLLDFANSERPLVVNFGSATUPPFTSQLSAFSKLVEEFSGVADFLLVYIDEAHPSDG 168 Query: 181 WVT---TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFER 234 W + S + + +H+S E+R +AA L + P C +V D M N+++ AYG FER Sbjct: 169 WAAPGISPSSFEVKKHKSQEERCAAAHQLLEHFSLPPQCQVVADCMDNNANVAYGVSFER 228 Query: 235 LYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + ++Q I Y GG+GP Y + E+R WLE Sbjct: 229 VCIVQRQKIAYLGGKGPFFYNLQEVRLWLE 258 >ref|NP_997954.2| type II iodothyronine deiodinase [Danio rerio] gb|AAH59608.2| Deiodinase, iodothyronine, type II [Danio rerio] Length = 257 Score = 155 bits (393), Expect = 2e-42 Identities = 79/201 (39%), Positives = 122/201 (60%), Gaps = 17/201 (8%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ-----------SQRILDYA 129 R+ T A ++++W+ LD +KQ G APNS+V++ G +LD+ Sbjct: 52 RMLTTAGVRSIWNSFLLDAYKQVKLGEAAPNSKVVKVTGINRCWSISGKTHNQCHLLDFE 111 Query: 130 QGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWV---TTDS 186 RPLV+NFGS T PPF++++ F+R+V ++ DFL++YI+EAHPSDGWV + Sbjct: 112 SPDRPLVVNFGSATUPPFISQLPVFRRMVEEFSDVADFLLVYIDEAHPSDGWVGPPMENF 171 Query: 187 PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTI 243 + + +HR+LE+R+ AAR L + P C LV D M N+++ AYG +ER+ ++Q I Sbjct: 172 SFEVRKHRNLEERMFAARTLLEHFSLPPQCQLVADCMDNNANIAYGVSYERVCIVQKNKI 231 Query: 244 MYQGGRGPDGYQVSELRTWLE 264 Y GG+GP Y + ++R WLE Sbjct: 232 AYLGGKGPFFYNLKDVRRWLE 252 >ref|XP_003411116.1| PREDICTED: LOW QUALITY PROTEIN: type I iodothyronine deiodinase-like [Loxodonta africana] Length = 241 Score = 155 bits (391), Expect = 2e-42 Identities = 86/177 (48%), Positives = 112/177 (63%), Gaps = 6/177 (3%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPF 147 LK W Q+L+ + EGGPAP+ V+ G Q I D+ QG RPLVLNFGSCT P F Sbjct: 67 LKVYW--QRLE--DKTEEGGPAPDCPVVCLSG-QRCNISDFMQGIRPLVLNFGSCTXPSF 121 Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 ++++ F+RLV + DFLIIYIEEAH +DGW ++ I HR+L+DR+ AA +L Sbjct: 122 LSKLDQFKRLVEDFSSMADFLIIYIEEAHATDGWAFKNN-VAIRNHRNLQDRLQAAHLLL 180 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 +P C +V+DTM N SS Y A ERLYV+Q G I+Y+G GP Y E+R LE Sbjct: 181 DRSPQCPVVVDTMQNVSSQLYAALPERLYVLQEGRILYKGKPGPWNYHPEEVRAVLE 237 >prf||1705292A iodothyronine deiodinase I Length = 258 Score = 155 bits (392), Expect = 3e-42 Identities = 91/190 (47%), Positives = 116/190 (61%), Gaps = 6/190 (3%) Query: 79 DNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPL 135 DN + T S++ W K+ + + +A GG APN V+R G Q + D+ QGSRPL Sbjct: 59 DNWVPTFFSIQYFWFVLKVRWQRLEDRAEYGGLAPNCTVVRLSG-QKCNVWDFIQGSRPL 117 Query: 136 VLNFGSCT*-PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHR 194 VLNFGSCT P F+ + F+RLV + DFLIIYIEEAH +DGW ++ I QHR Sbjct: 118 VLNFGSCTSCPSFLLKFDQFKRLVDDFASTADFLIIYIEEAHATDGWAFKNN-VDIRQHR 176 Query: 195 SLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGY 254 SL+DR+ AA +L +P C +V+DTM N SS Y A ERLYVIQ G I Y+G GP Y Sbjct: 177 SLQDRLRAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRICYKGKPGPWNY 236 Query: 255 QVSELRTWLE 264 E+R LE Sbjct: 237 NPEEVRAVLE 246 >ref|XP_003214410.1| PREDICTED: LOW QUALITY PROTEIN: type II iodothyronine deiodinase-like [Anolis carolinensis] Length = 266 Score = 155 bits (392), Expect = 3e-42 Identities = 86/208 (41%), Positives = 118/208 (56%), Gaps = 24/208 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-PDGFQSQ---------------- 123 R+ T L+ VW+ LD +KQ GG APNS VI P G Sbjct: 53 RMLTSEGLRCVWNSFLLDAYKQVKLGGEAPNSNVIHIPSGTGDNSNSSSRWKNSSGRYGM 112 Query: 124 --RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW 181 +LD+A+ RPLV+NFGS T PPF ++SAF +LV ++ DFL++YI+EAHPSDGW Sbjct: 113 ECHLLDFAKSERPLVVNFGSATXPPFTNQLSAFGKLVEEFSSVADFLLVYIDEAHPSDGW 172 Query: 182 VT--TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLY 236 S + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ Sbjct: 173 AAPGVSSSFEVKKHRNQEDRCAAAHQLLKRFSLPPQCQIVADCMDNNANVAYGVSFERVC 232 Query: 237 VIQSGTIMYQGGRGPDGYQVSELRTWLE 264 ++Q I Y GG+GP Y + E+R WLE Sbjct: 233 IVQRQKIAYLGGKGPFFYNLQEVRLWLE 260 >ref|XP_002915789.1| PREDICTED: LOW QUALITY PROTEIN: type I iodothyronine deiodinase-like [Ailuropoda melanoleuca] Length = 244 Score = 154 bits (389), Expect = 5e-42 Identities = 88/191 (46%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN L T ++ W K+ + + + GG APN V++ G QS I D+ QG+R Sbjct: 52 SYDNWLPTFYGMQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVQLSG-QSCNIWDFMQGNR 110 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RLV + DFLIIYIEEAH SDGW ++ I H Sbjct: 111 PLVLNFGSCTXPSFLFKFDQFKRLVEDFCSTADFLIIYIEEAHASDGWAFKNN-VNIRTH 169 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 R+L+DR+ AAR+L P C +V+DTM N S+ Y A ERLYV++ G I+Y+G GP Sbjct: 170 RNLQDRLQAARLLLDRTPRCPVVVDTMENESNWRYAALPERLYVLREGRILYKGKSGPWN 229 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 230 YHPEEVRAVLE 240 >ref|XP_003220351.1| PREDICTED: LOW QUALITY PROTEIN: type I iodothyronine deiodinase-like [Anolis carolinensis] Length = 246 Score = 154 bits (389), Expect = 5e-42 Identities = 82/163 (50%), Positives = 107/163 (65%), Gaps = 2/163 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +A +G PAPN+ V+ DG + ILD+ Q +RPLVL FGSCT P FM R F++L+ + Sbjct: 83 KALQGCPAPNTPVVDFDG-KIHHILDFMQDNRPLVLAFGSCTXPSFMFRFGEFKKLIEDF 141 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMA 221 DFL+IYIEEAH SDGW ++ I HR+L DR+ AA +L + P C++V+DTM Sbjct: 142 SFAADFLVIYIEEAHASDGWAFKNN-IVIKSHRTLHDRMQAAEILLKQYPLCSVVMDTME 200 Query: 222 NSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 N SSS Y A ERLYV+Q G I+Y+GG GP Y E+R LE Sbjct: 201 NLSSSTYAALPERLYVLQGGNIVYKGGVGPWNYNPQEVREVLE 243 >ref|NP_001116065.1| type I iodothyronine deiodinase [Bos taurus] gb|DAA31208.1| deiodinase, iodothyronine, type I [Bos taurus] Length = 249 Score = 154 bits (389), Expect = 6e-42 Identities = 86/191 (45%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S +N + T S + W K+ + + +GG APN V+R G + I D+ QG+R Sbjct: 57 SHENWIPTFFSTQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCS-IWDFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RL+ + DFLIIYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTUPSFIFKFDQFKRLIEDFGSVADFLIIYIEEAHASDGWAFKNN-VDIKNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 R+L+DR+ AA +L +P C +V+DTM N SSS Y A ERLYV+Q G ++Y+G GP Sbjct: 175 RNLQDRLRAAHLLLDRSPPCPVVVDTMTNQSSSCYAALPERLYVLQEGRVLYKGKPGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YHPEEVRAVLE 245 >ref|XP_001634053.1| predicted protein [Nematostella vectensis] gb|EDO41990.1| predicted protein [Nematostella vectensis] Length = 191 Score = 152 bits (383), Expect = 9e-42 Identities = 81/184 (44%), Positives = 117/184 (63%), Gaps = 9/184 (4%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDG-----FQSQRILDYAQGSRPLVLNFGSC 142 L+ +W+ ++D ++ G A ++ V+ D + R+LD+A+ RPLVLNFGS Sbjct: 10 LQTIWYCMQVDNHRKIRLGSKAVSTPVLESDENNNNHMATSRLLDHAKEGRPLVLNFGSY 69 Query: 143 T*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWV-TTDSPYTIPQHRSLEDRVS 201 + P F A +S F+ LV KY DFL++YIEEAHPSDGW D+P IP H+S DR Sbjct: 70 SCPIFRAYLSEFRTLVEKYSSVADFLVVYIEEAHPSDGWAFQNDTP--IPSHKSNIDRCV 127 Query: 202 AARVLQQGA-PGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELR 260 AA++L PGC +++D++ N+SS AYGA RL+V+ G + Y+GG GP Y++SE+R Sbjct: 128 AAKLLAGAVNPGCKILIDSLLNASSIAYGATPTRLHVVLDGVVGYEGGPGPMSYRISEVR 187 Query: 261 TWLE 264 WLE Sbjct: 188 QWLE 191 >sp|Q8UVX8|IOD2_NEOFS RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAL56981.2|AF327438_1 deiodinase type II [Neoceratodus forsteri] Length = 269 Score = 154 bits (388), Expect = 1e-41 Identities = 84/203 (41%), Positives = 121/203 (59%), Gaps = 20/203 (9%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPD------------GFQSQRILDY 128 R+ T L+ VW+ LD +KQ GG APNS+V+R G +LD+ Sbjct: 53 RMLTSEGLRTVWNSFLLDAYKQVKLGGDAPNSKVVRVTSGCCRRRSFSGKGESECHLLDF 112 Query: 129 AQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW----VTT 184 A +RPLV+NFGS T PPF++++ F++LV ++ DFL++YI+EAHP+DGW V T Sbjct: 113 ASSNRPLVVNFGSATUPPFISQLPTFRKLVEEFSDVADFLLVYIDEAHPADGWAAPGVAT 172 Query: 185 DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSG 241 S + + +HRS E+R AA L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 173 KS-FEVKKHRSQEERCVAAHKLLEHFSLPPQCQVVADCMDNNTNVAYGVSFERVCIVQRQ 231 Query: 242 TIMYQGGRGPDGYQVSELRTWLE 264 I Y GG+GP Y + E+R WLE Sbjct: 232 KIAYLGGKGPFFYNLKEVRHWLE 254 >emb|CAF02303.1| putative iodothyronine deiodinase type 1 [Sparus aurata] gb|ABK20154.1| iodothyronine deiodinase 1 [Sparus aurata] Length = 248 Score = 153 bits (386), Expect = 2e-41 Identities = 79/177 (44%), Positives = 116/177 (65%), Gaps = 2/177 (1%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPF 147 +K H + ++A GG AP+S V+ G +++ I Y G+RPLVL+FGSCT PPF Sbjct: 71 IKTASHHLWMSLGQEAFVGGKAPDSPVVTMKG-ETKNICKYLNGNRPLVLSFGSCTUPPF 129 Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 + ++ F+RLV + DFL++YI EAH +DGW S I +H+SLEDR+SAA++L Sbjct: 130 IFKLEEFKRLVRDFSDVADFLVVYIAEAHSTDGWAFA-SNIDISKHQSLEDRLSAAQILV 188 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 Q P C +V+D M + ++ YGA ERLYV+Q+G ++Y+G GP GY E+R++LE Sbjct: 189 QKEPLCPVVVDEMNDGAAIKYGAMPERLYVLQAGKVVYKGIEGPWGYDPQEVRSFLE 245 >ref|NP_001009267.1| type I iodothyronine deiodinase [Felis catus] sp|Q6V915|IOD1_FELCA RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|AAQ92943.1| type I iodothyronine deiodinase [Felis catus] Length = 244 Score = 152 bits (385), Expect = 2e-41 Identities = 88/191 (46%), Positives = 117/191 (61%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN TL S++ W K+ + + + GG APN V+R G Q I D+ +G+R Sbjct: 52 SYDNWAPTLYSVQYFWFVLKVRWQRLEDRTEPGGLAPNCPVVRLSG-QRCSIWDFMKGNR 110 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RL+ + DFLIIYIEEAH SDGW ++ I H Sbjct: 111 PLVLNFGSCTUPSFLFKFDQFKRLIEDFCSIADFLIIYIEEAHASDGWAFKNN-VNIRNH 169 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 R+L+DR+ AA +L +P C +V+DTM N SS Y A ERLYV+Q+G I+Y+G GP Sbjct: 170 RNLQDRLQAACLLLDRSPRCPVVVDTMKNQSSRLYAALPERLYVLQAGRILYKGKPGPWN 229 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 230 YHPEEVRAVLE 240 >ref|NP_001184161.2| type II iodothyronine deiodinase [Xenopus (Silurana) tropicalis] Length = 258 Score = 153 bits (386), Expect = 2e-41 Identities = 80/198 (40%), Positives = 118/198 (59%), Gaps = 14/198 (7%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRI----------LDYAQ 130 R+ T L+ VW+ LD +KQ G APNS VI+ + + LD+A Sbjct: 53 RMLTPEGLRCVWNSFLLDAYKQVKLGQDAPNSNVIQVSNKICKSVQRKLVGKCHLLDFAS 112 Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT-DSPYT 189 RPLV+NFGS T PPF++++ AF +LV ++ DF+++YI+EAHPSDGW + Y Sbjct: 113 SERPLVVNFGSATUPPFISQLPAFSKLVEEFSSVADFVLVYIDEAHPSDGWAAPGTTSYE 172 Query: 190 IPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQ 246 + +HR+ E+R +AA L + P C +V D M N+++ AYG FER+ ++Q I+Y Sbjct: 173 VKKHRNQEERCAAASKLLEHFSIPPQCQVVADCMDNNANVAYGVSFERVCIVQKQKIVYL 232 Query: 247 GGRGPDGYQVSELRTWLE 264 GG+GP Y + E+R WLE Sbjct: 233 GGKGPFFYNIQEIRRWLE 250 >gb|AFE86483.1| type I iodothyronine deiodinase [Bubalus bubalis] Length = 249 Score = 152 bits (385), Expect = 2e-41 Identities = 85/191 (44%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S +N + T S + W K+ + + +GG APN V+R G + I D+ QG+R Sbjct: 57 SHENWIPTFFSAQYFWFILKVRWQRLEDMTEQGGLAPNCPVVRLSGERCS-IWDFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RL+ + DFLIIYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTUPSFIFKFDQFKRLIEDFGSIADFLIIYIEEAHASDGWAFKNN-VDIKNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AA +L +P C +V+DTM N SSS Y A ERLYV+Q G ++Y+G GP Sbjct: 175 QNLQDRLRAAHLLLDRSPQCPVVVDTMTNQSSSCYAALPERLYVLQEGRVLYKGKPGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YHPEEVRAVLE 245 >ref|NP_000783.2| type I iodothyronine deiodinase isoform a [Homo sapiens] sp|P49895|IOD1_HUMAN RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|AAB23670.2| type I 5' iodothyronine deiodinase [Homo sapiens] gb|AAT02480.1| type I iodothyronine deiodinase splice variant a [Homo sapiens] gb|AAI07172.1| Deiodinase, iodothyronine, type I [Homo sapiens] gb|AAI07171.1| Deiodinase, iodothyronine, type I [Homo sapiens] Length = 249 Score = 152 bits (385), Expect = 2e-41 Identities = 86/191 (45%), Positives = 114/191 (59%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + GG APN V+R G Q I ++ QG+R Sbjct: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSG-QRCNIWEFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P FM + F+RL+ + DFL+IYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNN-MDIRNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AA +L +P C +V+DTM N SS Y A ERLY+IQ G I+Y+G GP Sbjct: 175 QNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YNPEEVRAVLE 245 >ref|NP_001001627.1| type I iodothyronine deiodinase [Sus scrofa] sp|Q6QN13|IOD1_PIG RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|AAS48447.1| type I iodothyronine deiodinase [Sus scrofa] Length = 249 Score = 152 bits (385), Expect = 2e-41 Identities = 86/191 (45%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S +N + T S + W K+ + + + EGG APN V+ G Q I D+ QG+R Sbjct: 57 SHENWIPTFFSAQYFWFVLKVRWQRLEDKTEEGGLAPNCPVVSLSG-QRCHIWDFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P F+ + F+RL+ + DFLIIYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTUPSFIFKFDQFKRLIEDFSSIADFLIIYIEEAHASDGWAFKNN-VDIKNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYV+Q+G I+Y+G GP Sbjct: 175 QNLQDRLRAAHLLLDRSPQCPVVVDTMKNQSSRLYAALPERLYVLQAGRILYKGKPGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YHPEEVRAVLE 245 >ref|NP_001243226.1| deiodinase, iodothyronine, type 1 [Xenopus (Silurana) tropicalis] Length = 252 Score = 152 bits (385), Expect = 2e-41 Identities = 89/206 (43%), Positives = 121/206 (58%), Gaps = 3/206 (1%) Query: 60 LNSEGEEVPADDPPICVSD-DNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPD 118 L S E DP D T L++V L +A G APN+ VI + Sbjct: 46 LKSRFETTGVHDPKFQYEDWGPTFFTYKFLRSVLEIMWLRLEDEAFVGHSAPNTPVIDLN 105 Query: 119 GFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPS 178 G + I DY QG+RPLVLNFGSCT PPF+ R+ F +LV + DFLIIYI+EAH + Sbjct: 106 G-ELHHIWDYLQGTRPLVLNFGSCTUPPFLFRLGEFNKLVNDFSSIADFLIIYIDEAHAA 164 Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 D W ++ + I +HR L+DR++AA+ L + P C +VLDTM+N S+ Y A ERLY++ Sbjct: 165 DEWALKNNLH-IKKHRCLQDRLAAAKRLLEELPSCPVVLDTMSNLCSAKYAALPERLYIL 223 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP GY+ E+ + LE Sbjct: 224 QEGKIIYKGKMGPWGYKPEEVHSVLE 249 >ref|NP_001243691.1| type II iodothyronine deiodinase [Cricetulus griseus] Length = 266 Score = 152 bits (385), Expect = 3e-41 Identities = 86/205 (41%), Positives = 119/205 (58%), Gaps = 22/205 (10%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---------------PDGFQSQRI 125 R+ T L+ VW LD +KQ G APNS V+ DG + + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGSNYALEKTADGAECH-L 111 Query: 126 LDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTT 184 LD+A RPLV+NFGS T PPF ++ AF++LV ++ DFL++YI+EAHPSDGW V Sbjct: 112 LDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPG 171 Query: 185 DS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQ 239 DS + + +HRS EDR +AA L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 172 DSSLSFEVKKHRSQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQ 231 Query: 240 SGTIMYQGGRGPDGYQVSELRTWLE 264 I Y GG+GP Y + E+R+WLE Sbjct: 232 RQKIAYLGGKGPFSYNLQEVRSWLE 256 >ref|NP_034180.1| type II iodothyronine deiodinase [Mus musculus] sp|Q9Z1Y9|IOD2_MOUSE RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAD53113.1|AF177196_1 type II 5'-iodothyronine deiodinase [Mus musculus] gb|AAF00069.2|AF093137_1 type II deiodinase [Mus musculus] gb|AAD11422.1| type 2 deiodinase [Mus musculus] gb|AAI25384.1| Deiodinase, iodothyronine, type II [Mus musculus] gb|AAI25386.1| Deiodinase, iodothyronine, type II [Mus musculus] Length = 266 Score = 152 bits (385), Expect = 3e-41 Identities = 84/204 (41%), Positives = 119/204 (58%), Gaps = 20/204 (9%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQR--------------IL 126 R+ T L+ VW+ LD +KQ G APNS V+ +S +L Sbjct: 53 RMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLL 112 Query: 127 DYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTTD 185 D+A RPLV+NFGS T PPF ++ AF++LV ++ DFL++YI+EAHPSDGW V D Sbjct: 113 DFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGD 172 Query: 186 S--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQS 240 S + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 173 SSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQR 232 Query: 241 GTIMYQGGRGPDGYQVSELRTWLE 264 I Y GG+GP Y + E+R+WLE Sbjct: 233 RKIAYLGGKGPFSYNLQEVRSWLE 256 >ref|NP_001089136.1| type I iodothyronine deiodinase [Xenopus laevis] sp|Q2QEI3|IOD1_XENLA RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|AAZ43088.1| type I iodothyronine deiodinase [Xenopus laevis] Length = 252 Score = 152 bits (383), Expect = 5e-41 Identities = 78/163 (47%), Positives = 111/163 (68%), Gaps = 2/163 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +A G APN+ V+ G + I DY QG+RPLVL+FGSCT PPF+ R+ F +LV ++ Sbjct: 89 EAFVGHSAPNTPVVDLSG-ELHHIWDYLQGTRPLVLSFGSCTUPPFLFRLGEFNKLVNEF 147 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMA 221 DFLIIYI+EAH +D W ++ + I +HRSL+DR++AA+ L + +P C +VLDTM+ Sbjct: 148 NSIADFLIIYIDEAHAADEWALKNNLH-IKKHRSLQDRLAAAKRLMEESPSCPVVLDTMS 206 Query: 222 NSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 N S+ Y A ERLY++Q G I+Y+G GP GY+ E+ + LE Sbjct: 207 NLCSAKYAALPERLYILQEGKIIYKGKMGPWGYKPEEVCSVLE 249 >ref|NP_113908.3| type II iodothyronine deiodinase [Rattus norvegicus] sp|P70551|IOD2_RAT RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAC52767.1| type II iodothyronine deiodinase [Rattus norvegicus] Length = 266 Score = 152 bits (384), Expect = 5e-41 Identities = 82/205 (40%), Positives = 118/205 (57%), Gaps = 22/205 (10%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---------------PDGFQSQRI 125 R+ T L+ VW+ LD +KQ G APNS V+ DG + + Sbjct: 53 RMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGNNCASEKTADGAECH-L 111 Query: 126 LDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT-- 183 LD+A RPLV+NFGS T PPF ++ AF++LV ++ DFL++YI+EAHPSDGW Sbjct: 112 LDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPG 171 Query: 184 -TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQ 239 + + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 172 DSSMSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQ 231 Query: 240 SGTIMYQGGRGPDGYQVSELRTWLE 264 I Y GG+GP Y + E+R+WLE Sbjct: 232 RRKIAYLGGKGPFSYNLQEVRSWLE 256 >gb|AEO36971.1| deiodinase 2 [Microtus arvalis] Length = 257 Score = 152 bits (383), Expect = 5e-41 Identities = 83/204 (40%), Positives = 119/204 (58%), Gaps = 20/204 (9%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQR--------------IL 126 R+ T L+ VW LD +KQ G APNS V+ ++ +L Sbjct: 50 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSNPEADNNYALKKTADGAECHLL 109 Query: 127 DYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTTD 185 D+A RPLV+NFGS T PPF ++ AF++LV ++ DFL++YI+EAHPSDGW V D Sbjct: 110 DFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGD 169 Query: 186 S--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQS 240 S + + +HR+ EDR +AA+ L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 170 SSLSFEVKKHRNQEDRCAAAQQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQR 229 Query: 241 GTIMYQGGRGPDGYQVSELRTWLE 264 I Y GG+GP Y + E+R+WLE Sbjct: 230 QKIAYLGGKGPFNYNLQEVRSWLE 253 >ref|NP_001129993.1| iodothyronine deiodinase type II [Oryzias latipes] dbj|BAG68690.1| iodothyronine deiodinase type II [Oryzias latipes] Length = 277 Score = 152 bits (384), Expect = 6e-41 Identities = 84/212 (39%), Positives = 123/212 (58%), Gaps = 28/212 (13%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-----------------PDGFQSQ 123 R+ T A L+A+W+ LD +KQ G APNS+V++ P G ++Q Sbjct: 54 RMLTSAGLRAIWNSFLLDAYKQVKLGCEAPNSKVVKVPESPRWSSSIKSMTSVPRGARAQ 113 Query: 124 -----RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPS 178 R+LD+ RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPS Sbjct: 114 TGDECRLLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPS 173 Query: 179 DGWVTTD---SPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYF 232 DGWV ++ +H++LE+R+ AAR L + P C LV D M N+++ AYG Sbjct: 174 DGWVAPQMGPCSFSFRKHQNLEERMGAARQLTEHFSLPPQCQLVADCMDNNANVAYGVSN 233 Query: 233 ERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 ER+ ++ I Y GG+GP Y + E+R WLE Sbjct: 234 ERVCIVHQRKIAYLGGKGPFFYNLKEVRQWLE 265 >gb|AFP99133.1| deiodinase 1 [Sebastiscus marmoratus] Length = 248 Score = 151 bits (381), Expect = 9e-41 Identities = 79/177 (44%), Positives = 117/177 (66%), Gaps = 2/177 (1%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPF 147 ++A H L + A GG AP++ V+ +G ++ I Y + +RPLVL+FGSCT PPF Sbjct: 71 IRAASHHLWLSLGQDAFMGGEAPDTPVVTMEGKKTS-ICKYLKDNRPLVLSFGSCTUPPF 129 Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M ++ F++LV + DFL+IYI EAH DGW ++ + I QH+SLEDR+SAA+++ Sbjct: 130 MYKLEEFKQLVKDFSDVADFLVIYIAEAHSKDGWAFANN-FDINQHQSLEDRLSAAQIVV 188 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 Q P C +V+D M + S+ YGA ERLYV+Q+G ++Y+G GP GY E+R++LE Sbjct: 189 QKEPLCPVVVDEMNDLSTIKYGAMPERLYVLQAGKVVYKGSVGPWGYSPMEVRSFLE 245 >ref|XP_002750893.2| PREDICTED: LOW QUALITY PROTEIN: type I iodothyronine deiodinase [Callithrix jacchus] Length = 249 Score = 151 bits (381), Expect = 9e-41 Identities = 87/191 (45%), Positives = 112/191 (58%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + GG APN V+ G Q I D+ QG+R Sbjct: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVHLSG-QRCNIWDFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P FM + F+RL + DFLIIYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTXPSFMFKFDQFKRLTEDFSSVADFLIIYIEEAHASDGWAFKNN-VDIRNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AA +L +P C +V+DTM N SS Y A ERLY+IQ G I+Y+G GP Sbjct: 175 QNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSELYAALPERLYIIQEGRILYKGKSGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YNPEEVRDVLE 245 >ref|NP_001116123.1| type I iodothyronine deiodinase [Pan troglodytes] Length = 249 Score = 150 bits (380), Expect = 1e-40 Identities = 85/191 (44%), Positives = 113/191 (59%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + GG APN V+ G Q I ++ QG+R Sbjct: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVHLSG-QRCNIWEFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P FM + F+RL+ + DFL++YIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVVYIEEAHASDGWAFKNN-MDIRNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVIQ G I+Y+G GP Sbjct: 175 QNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRILYKGKSGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YNPEEVRAVLE 245 >dbj|BAA25186.1| type II iodothyronine deiodinase [Rattus rattus] Length = 266 Score = 151 bits (381), Expect = 1e-40 Identities = 82/205 (40%), Positives = 118/205 (57%), Gaps = 22/205 (10%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---------------PDGFQSQRI 125 R+ T L+ VW+ LD +KQ G APNS V+ DG + + Sbjct: 53 RMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGNNCASEKTADGAECH-L 111 Query: 126 LDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT-- 183 LD+A RPLV+NFGS T PPF ++ AF++LV ++ DFL++YI+EAHPSDGW Sbjct: 112 LDFACAERPLVVNFGSATXPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPG 171 Query: 184 -TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQ 239 + + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 172 DSSMSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQ 231 Query: 240 SGTIMYQGGRGPDGYQVSELRTWLE 264 I Y GG+GP Y + E+R+WLE Sbjct: 232 RRKIAYLGGKGPFSYNLQEVRSWLE 256 >ref|NP_001244906.1| type II iodothyronine deiodinase [Cavia porcellus] Length = 269 Score = 151 bits (381), Expect = 1e-40 Identities = 83/207 (40%), Positives = 118/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQ-------------- 123 R+ T L+ VW LD +KQ G APNS V+R P+G S Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVRVSSPEGGHSGGNRVQEKTAEGVQC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT 183 +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++YI+EAHPSDGW Sbjct: 113 HLLDFASAERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAI 172 Query: 184 ---TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 + + + +HR+ E+R +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGGSSLSFEVKKHRNQEERCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFCYNLQEVRRWLE 259 >sp|Q95N00|IOD1_SUNMU RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase dbj|BAB62750.1| type I 5'-deiodinase [Suncus murinus] Length = 257 Score = 150 bits (380), Expect = 1e-40 Identities = 83/177 (46%), Positives = 111/177 (62%), Gaps = 6/177 (3%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPF 147 LK W Q+L+ + +G AP+S V+ G Q R+ D+ QG+RPLVLNFGSC+ P F Sbjct: 75 LKVNW--QQLE--DRTKQGDIAPDSPVVHLSG-QRARLWDFMQGNRPLVLNFGSCSUPSF 129 Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 + + F+RLV + DFL +YIEEAH SDGW ++ I +HR L++R+ AAR+L Sbjct: 130 LFKFDQFKRLVEDFSSVADFLTVYIEEAHASDGWAFKNN-VDIRRHRDLQERLQAARLLL 188 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 PGC +V+DTM N SS Y A ERLYV+Q G I+Y+GG GP Y E+ LE Sbjct: 189 DRNPGCPVVVDTMENRSSQLYAALPERLYVLQEGRILYKGGPGPWNYHPEEVHAVLE 245 >ref|NP_001093428.1| type I iodothyronine deiodinase [Oryctolagus cuniculus] sp|A4GT88|IOD1_RABIT RecName: Full=Type I iodothyronine deiodinase; AltName: Full=5DI; AltName: Full=DIOI; AltName: Full=Type 1 DI; AltName: Full=Type-I 5'-deiodinase gb|ABO21318.1| type I iodothyronine deiodinase isoform a [Oryctolagus cuniculus] Length = 249 Score = 150 bits (379), Expect = 2e-40 Identities = 83/177 (46%), Positives = 110/177 (62%), Gaps = 6/177 (3%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPF 147 LK W Q+L+ GG APN V+R G Q + D+ +G+RPLVLNFGSCT P F Sbjct: 75 LKVRW--QRLE--DATEPGGLAPNCSVVRLSGQQCS-VWDFMRGNRPLVLNFGSCTUPSF 129 Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 +++ F+RL+ + DFLIIYIEEAH SDGW ++ I HR+L+DR+ AA +L Sbjct: 130 LSKFDQFKRLIQDFSSIADFLIIYIEEAHASDGWAFKNN-VDIKNHRNLQDRLRAASLLL 188 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 +P C +V+DTM N SS Y A ERLYV++ G I+Y+G GP Y E+R LE Sbjct: 189 ARSPQCPVVVDTMQNQSSQLYAALPERLYVLRQGRILYKGESGPWNYNPEEVRAVLE 245 >ref|XP_003339533.1| PREDICTED: LOW QUALITY PROTEIN: type II iodothyronine deiodinase-like [Monodelphis domestica] Length = 268 Score = 150 bits (379), Expect = 3e-40 Identities = 83/210 (39%), Positives = 118/210 (56%), Gaps = 26/210 (12%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-------------------PDGFQ 121 R+ T L+ VW LD +KQ GG APNS VI G+ Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGGDAPNSSVIHITSAEVGSGQQNNSRWKRFDGGYG 112 Query: 122 SQ-RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 ++ +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++YI+EAHPSDG Sbjct: 113 AECHLLDFANPERPLVVNFGSATXPPFTSQLPAFSKLVEEFSTVADFLLVYIDEAHPSDG 172 Query: 181 WV---TTDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFER 234 W + + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER Sbjct: 173 WAVPGNSSVSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANIAYGVSFER 232 Query: 235 LYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + ++Q I Y GG+GP Y + E+R WLE Sbjct: 233 VCIVQRQKIAYLGGKGPFFYNLQEVRLWLE 262 >ref|NP_001244903.1| type I iodothyronine deiodinase [Cavia porcellus] Length = 249 Score = 149 bits (377), Expect = 3e-40 Identities = 86/191 (45%), Positives = 115/191 (60%), Gaps = 5/191 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + A GG AP+ V+ G + + I D+ G+R Sbjct: 57 SHDNWIPTFFSTQYFWFILKVRWQRLEETAELGGLAPDCSVVCLSG-EKRTIWDFMHGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P FM + F+RL+ + DFLIIYIEEAH SDGW ++ I QH Sbjct: 116 PLVLNFGSCTUPSFMFKFDQFKRLIEDFHPIADFLIIYIEEAHASDGWAFKNN-VDIRQH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 ++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYV+Q G I+Y+G GP Sbjct: 175 QNLQDRMRAAHLLLAKSPQCPVVVDTMQNESSQLYAALPERLYVLQEGRILYKGKSGPWN 234 Query: 254 YQVSELRTWLE 264 Y E+R LE Sbjct: 235 YNPEEVRGVLE 245 >ref|NP_001243229.1| deiodinase, iodothyronine, type II [Oryctolagus cuniculus] Length = 269 Score = 150 bits (378), Expect = 4e-40 Identities = 85/207 (41%), Positives = 120/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRP----------DGFQSQ------- 123 R+ T L+ VW LD +KQ G APNS V+ +G Q + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEAGAGAGNGAQDKTADGAEC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF++LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFASSERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLAFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFCYNLQEVRRWLE 259 >dbj|BAG15907.1| iodothyronine deiodinase type II [Paralichthys olivaceus] Length = 271 Score = 150 bits (378), Expect = 4e-40 Identities = 82/212 (38%), Positives = 123/212 (58%), Gaps = 28/212 (13%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-PDG-------------------- 119 R+ T A L+++W+ LD +KQ G AP+S+V++ PDG Sbjct: 54 RMLTSAGLRSIWNSFLLDAYKQVKLGCEAPDSKVVKVPDGPWCSSNISNVTNVPTGARMR 113 Query: 120 -FQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPS 178 R+LD+ RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPS Sbjct: 114 NGDECRLLDFGSSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPS 173 Query: 179 DGWVTT---DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYF 232 DGWV S + + +H++LE+R+ AAR L + P C LV D M N+++ AYG Sbjct: 174 DGWVAPPMGSSSFNVRKHQNLEERLGAARKLTEHFSLPPQCHLVADCMDNNANVAYGVSN 233 Query: 233 ERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 ER+ ++Q I Y GG+GP Y + +++ WLE Sbjct: 234 ERVCIVQQRKIAYLGGKGPFFYNLKDVQKWLE 265 >ref|NP_001159927.1| type II iodothyronine deiodinase [Equus caballus] Length = 269 Score = 149 bits (377), Expect = 5e-40 Identities = 83/207 (40%), Positives = 121/207 (58%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVI----------RPDGFQSQRI----- 125 R+ T ++ +W LD +KQ G APNS V+ R +G Q + + Sbjct: 53 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSNPDRGDNRGNGAQGKTVDGTEC 112 Query: 126 --LDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 LD+A RPLV+NFGS T PPF++++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFASSERPLVVNFGSATUPPFISQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +H++ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLSFEVKKHQNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFYYNLQEVRRWLE 259 >gb|ADB46158.1| type II iodothyronine deiodinase [Siganus guttatus] Length = 270 Score = 149 bits (377), Expect = 6e-40 Identities = 86/221 (38%), Positives = 126/221 (57%), Gaps = 31/221 (14%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-----------------PDGFQSQ 123 R+ T A L+++W+ LD +KQ G APNS++++ PD Sbjct: 54 RMLTSAGLRSIWNSFLLDAYKQVKLGCEAPNSKLVKVPEGSRWSTTISDSSVPPDARIRN 113 Query: 124 R----ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSD 179 R +LD+ RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPSD Sbjct: 114 RDECHLLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSD 173 Query: 180 GWVTT---DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFE 233 GWV +++ +H+SLE+R+ AAR L + P C LV D M N+++ AYG E Sbjct: 174 GWVAPPMGSCSFSVRKHQSLEERLRAARKLIEHFSLPPQCQLVADCMDNNANVAYGVSNE 233 Query: 234 RLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYDEQLHGTR 274 R+ ++Q I Y GG+GP Y + E+R WL EQ +G R Sbjct: 234 RVCIVQQRKIAYLGGKGPFFYNLREVRQWL----EQTYGKR 270 >ref|NP_001116110.1| type II iodothyronine deiodinase isoform 2 [Pan troglodytes] Length = 273 Score = 149 bits (376), Expect = 8e-40 Identities = 83/207 (40%), Positives = 122/207 (58%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRP----------DGFQSQ------- 123 R+ T L+ VW LD +KQ G APNS V+ +G Q + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSAEGGDNSGNGTQEKIAEGATC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF++LV ++ DFL++YI+EAHPSDGW + Sbjct: 113 HLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAI 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +H++ EDR +AA+ L + P C +V D+M N+++ AYG FER+ + Sbjct: 173 PGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADSMDNNANIAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFSYNLQEVRHWLE 259 >gb|ABO21650.1| iodothyronine type II deiodinase [Oryctolagus cuniculus] Length = 262 Score = 149 bits (375), Expect = 9e-40 Identities = 85/207 (41%), Positives = 119/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRP----------DGFQSQ------- 123 R+ T L+ VW LD +KQ G APNS V+ +G Q + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEAGAGAGNGAQDKTADGAEC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF+ LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFASSERPLVVNFGSATUPPFTSQLPAFRXLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLAFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFCYNLQEVRRWLE 259 >ref|NP_001117740.1| type II iodothyronine deiodinase [Oncorhynchus mykiss] gb|AAL25653.1| type II iodothyronine deiodinase [Oncorhynchus mykiss] gb|AAL25715.1| type II iodothyronine deiodinase [Oncorhynchus mykiss] Length = 264 Score = 149 bits (375), Expect = 1e-39 Identities = 82/206 (39%), Positives = 121/206 (58%), Gaps = 22/206 (10%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQR---------------- 124 R+ T A L+++W+ LD +KQ G APNS+V++ G +R Sbjct: 53 RMLTSAGLRSIWNSFLLDAYKQVKLGFEAPNSKVVKVPGSIRRRSSLTSTTGPHLGDECR 112 Query: 125 ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT 184 +LD+ RPLV+NFGS T PPF++ + AF+RLV ++ DFL++YI+EAHPSDGWV Sbjct: 113 LLDFESSDRPLVVNFGSATUPPFISHLPAFRRLVEEFSDVADFLLVYIDEAHPSDGWVAP 172 Query: 185 ---DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVI 238 + + +HRSLE+RV AA+ L + C LV D M N+++ AYG ER+ ++ Sbjct: 173 AMGPRSFEVRKHRSLEERVVAAKKLIESFSLPSQCQLVADCMDNNANVAYGVSNERVCIV 232 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q I Y GG+GP Y + ++R +LE Sbjct: 233 QRRKIAYLGGKGPFFYNLKDVRQYLE 258 >ref|XP_002590630.1| hypothetical protein BRAFLDRAFT_123596 [Branchiostoma floridae] gb|EEN46641.1| hypothetical protein BRAFLDRAFT_123596 [Branchiostoma floridae] Length = 451 Score = 152 bits (385), Expect = 1e-39 Identities = 86/213 (40%), Positives = 125/213 (58%), Gaps = 9/213 (4%) Query: 65 EEVPADDPPICVSDDN----RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGF 120 + V A+ +C D TL S KA+ + Q + FK +G PA +S +++ DG Sbjct: 47 QRVLANAKSMCPKGDTFQIEEFLTLKSYKALLYSQAVGIFKVVRKGRPAEDSALVQLDGQ 106 Query: 121 QSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 +L Y G+RPLV+ FGS T PPF +S F L YQ +FL++YIEEAHPSDG Sbjct: 107 TETTLLSYTSGTRPLVVCFGSYTCPPFRDALSDFAVLAQDYQNVANFLLVYIEEAHPSDG 166 Query: 181 WVTTDSPYTIPQHRSLEDRVSAAR-VLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQ 239 W P I QHR++E R AAR +L+ + +DTM N+++ YGA+ +RLYVIQ Sbjct: 167 WRFNSGP-QIQQHRTVEQRCDAARAMLRDRGVQFDVAVDTMGNAANHTYGAFPDRLYVIQ 225 Query: 240 SGTIMYQGGRGPDGYQVSELRTWLEHYDEQLHG 272 +G + ++GG+GP + +E+R WL +E L+G Sbjct: 226 NGVVAHEGGKGPFLFNPTEVREWL---NEHLNG 255 >ref|XP_003756244.1| PREDICTED: type II iodothyronine deiodinase [Sarcophilus harrisii] Length = 268 Score = 148 bits (374), Expect = 1e-39 Identities = 81/210 (38%), Positives = 118/210 (56%), Gaps = 26/210 (12%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-------------------PDGFQ 121 R+ T L+ VW LD +KQ GG APNS V+ G+ Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGGDAPNSSVVHITSAEVGNGQQNNSKWKRFDGGYG 112 Query: 122 SQ-RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 ++ +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++YI+EAHPSDG Sbjct: 113 AECHLLDFANPERPLVVNFGSATXPPFTSQLPAFSKLVEEFSTVADFLLVYIDEAHPSDG 172 Query: 181 WV---TTDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFER 234 W + + + +H++ EDR +AA L + P C +V D M N+++ AYG FER Sbjct: 173 WAVPGNSSVSFEVKKHQNQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANIAYGVSFER 232 Query: 235 LYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + ++Q I Y GG+GP Y + E+R WLE Sbjct: 233 VCIVQRQKIAYLGGKGPFFYNLQEVRLWLE 262 >ref|NP_054644.1| type II iodothyronine deiodinase isoform a [Homo sapiens] ref|NP_000784.2| type II iodothyronine deiodinase isoform a [Homo sapiens] sp|Q92813|IOD2_HUMAN RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAD45494.1|AC007372_1 type 2 iodothyronine deiodinase [Homo sapiens] gb|AAC50663.1| type II iodothyronine deiodinase [Homo sapiens] gb|AAH74882.1| Deiodinase, iodothyronine, type II [Homo sapiens] gb|AAI36515.1| Deiodinase, iodothyronine, type II [Homo sapiens] Length = 273 Score = 148 bits (374), Expect = 2e-39 Identities = 83/207 (40%), Positives = 121/207 (58%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRP----------DGFQSQ------- 123 R+ T L+ VW LD +KQ G APNS V+ +G Q + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF++LV ++ DFL++YI+EAHPSDGW + Sbjct: 113 HLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAI 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +H++ EDR +AA+ L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFSYNLQEVRHWLE 259 >ref|NP_001001626.1| type II iodothyronine deiodinase [Sus scrofa] gb|AAS48448.1| type II iodothyronine deiodinase [Sus scrofa] Length = 265 Score = 148 bits (373), Expect = 2e-39 Identities = 82/207 (39%), Positives = 119/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQ-------------- 123 R+ T ++ +W LD +KQ G APNS V+ P+G + Sbjct: 53 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSNPEGSNNHGHGTQEKTVDGAEC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFANPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +H++ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLSFEVKKHQNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFYYNLQEVRRWLE 259 >gb|AAC95470.1| type 2 iodothyronine deiodinase [Homo sapiens] Length = 280 Score = 148 bits (374), Expect = 2e-39 Identities = 83/207 (40%), Positives = 121/207 (58%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRP----------DGFQSQ------- 123 R+ T L+ VW LD +KQ G APNS V+ +G Q + Sbjct: 60 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATC 119 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF++LV ++ DFL++YI+EAHPSDGW + Sbjct: 120 HLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAI 179 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +H++ EDR +AA+ L + P C +V D M N+++ AYG FER+ + Sbjct: 180 PGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCI 239 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 240 VQRQKIAYLGGKGPFSYNLQEVRHWLE 266 >sp|Q6QN12|IOD2_PIG RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase Length = 269 Score = 148 bits (373), Expect = 2e-39 Identities = 82/207 (39%), Positives = 119/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQ-------------- 123 R+ T ++ +W LD +KQ G APNS V+ P+G + Sbjct: 53 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSNPEGSNNHGHGTQEKTVDGAEC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFANPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +H++ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLSFEVKKHQNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFYYNLQEVRRWLE 259 >ref|NP_001116117.1| type II iodothyronine deiodinase [Canis lupus familiaris] Length = 269 Score = 148 bits (373), Expect = 2e-39 Identities = 83/207 (40%), Positives = 119/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQR------------- 124 R+ T ++ +W LD +KQ G APNS V+ +G + R Sbjct: 53 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSNSEGGDNSRNGAQVKIVDGAEC 112 Query: 125 -ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFASPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFYYNLQEVRRWLE 259 >ref|NP_001010992.1| type II iodothyronine deiodinase [Bos taurus] sp|Q5I3B2|IOD2_BOVIN RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAW51123.1| type II iodothyronine deiodinase [Bos taurus] gb|DAA25003.1| type II iodothyronine deiodinase [Bos taurus] Length = 269 Score = 148 bits (373), Expect = 2e-39 Identities = 83/207 (40%), Positives = 118/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQ-------------- 123 R+ T ++ +W LD +KQ G APNS V+ P+G + Sbjct: 53 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTEC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF ++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFASPERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDSP--YTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLFFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFFYNLQEVRRWLE 259 >gb|ACX31206.1| deiodinase 2 [Ovis aries] Length = 260 Score = 147 bits (372), Expect = 2e-39 Identities = 83/207 (40%), Positives = 119/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVI---RPDGFQSQ-------------- 123 R+ T ++ +W LD +KQ G APNS V+ P+G + Sbjct: 50 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSRVVPVSSPEGGDTAGNDAQEKTADGTEC 109 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF ++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 110 HLLDFASPERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 169 Query: 183 TTDSP--YTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +HR+ EDR +AA+ L + P C +V D M N+++ AYG FER+ + Sbjct: 170 PGDSSLFFEVKKHRNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCI 229 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 230 VQRQKIAYLGGKGPFFYNLQEVRRWLE 256 >gb|AAB39651.2| type II iodothyronine deiodinase [Fundulus heteroclitus] Length = 266 Score = 147 bits (371), Expect = 4e-39 Identities = 81/207 (39%), Positives = 120/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-PDGFQSQ---------------- 123 R+ T L+++W+ LD KQ G APNS+V++ PDG + Sbjct: 54 RMLTSEGLRSIWNSFLLDAHKQVKLGCEAPNSKVVKVPDGPRWSSTVVPCGSRIQAGGEC 113 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT 183 R+LD+ RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPSDGWV Sbjct: 114 RLLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVA 173 Query: 184 TD---SPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 ++ +H++LE+R+ AAR L + P C LV D M N+++ AYG ER+ + Sbjct: 174 PQMGACSFSFRKHQNLEERIGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVANERVCI 233 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 + I Y GG+GP Y + ++R WLE Sbjct: 234 VHQRKIAYLGGKGPFFYSLKDVRQWLE 260 >sp|P79747|IOD2_FUNHE RecName: Full=Type II iodothyronine deiodinase; AltName: Full=5DII; AltName: Full=DIOII; AltName: Full=Type 2 DI; AltName: Full=Type-II 5'-deiodinase gb|AAC79662.2| deiodinase type 2 [Fundulus heteroclitus] gb|AAL62449.1| deiodinase type 2 [Fundulus heteroclitus] Length = 266 Score = 147 bits (371), Expect = 4e-39 Identities = 81/207 (39%), Positives = 120/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-PDGFQSQ---------------- 123 R+ T L+++W+ LD KQ G APNS+V++ PDG + Sbjct: 54 RMLTSEGLRSIWNSFLLDAHKQVKLGCEAPNSKVVKVPDGPRWSSTVVPCGSRIQTGGEC 113 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT 183 R+LD+ RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPSDGWV Sbjct: 114 RLLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVA 173 Query: 184 TD---SPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 ++ +H++LE+R+ AAR L + P C LV D M N+++ AYG ER+ + Sbjct: 174 PQMGACSFSFRKHQNLEERIGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVANERVCI 233 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 + I Y GG+GP Y + ++R WLE Sbjct: 234 VHQRKIAYLGGKGPFFYSLKDVRQWLE 260 >ref|XP_002919093.1| PREDICTED: LOW QUALITY PROTEIN: type II iodothyronine deiodinase-like [Ailuropoda melanoleuca] Length = 272 Score = 147 bits (371), Expect = 4e-39 Identities = 83/207 (40%), Positives = 119/207 (57%), Gaps = 23/207 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQR------------- 124 R+ T ++ +W LD +KQ G APNS V+ +G + R Sbjct: 53 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSSVVHVSNSEGGDNGRNGAQVTMVDGAEC 112 Query: 125 -ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 113 HLLDFASPERPLVVNFGSATXPPFTSQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 172 Query: 183 TTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +HR+ EDR +AA L + P C +V D M N+++ AYG FER+ + Sbjct: 173 PGDSSLSFEVKKHRNQEDRCAAAHQLLEHFSLPPQCRVVADRMDNNANVAYGVAFERVCI 232 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 233 VQRQKIAYLGGKGPFCYNLQEVRRWLE 259 >ref|NP_001129616.1| iodothyronine deiodinase type I [Takifugu rubripes] dbj|BAG12771.1| iodothyronine deiodinase type I [Takifugu rubripes] Length = 248 Score = 146 bits (369), Expect = 5e-39 Identities = 84/203 (41%), Positives = 124/203 (61%), Gaps = 4/203 (1%) Query: 64 GEEVPADDPPICVSDDNRL--CTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ 121 GE+ P+ +D L + A +K L ++A G A +S V+ + + Sbjct: 45 GEKATMTQNPLFKYEDWGLTFASTALVKTASRHMWLSLGQEAFAGLEASDSPVVTMERKR 104 Query: 122 SQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW 181 S I + + +RPLVLNFGSCT PPFM ++ F++LV + DFL++YI EAH +DGW Sbjct: 105 SS-IGESMKANRPLVLNFGSCTUPPFMFKLEEFKQLVRDFSDVADFLVVYIAEAHSTDGW 163 Query: 182 VTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSG 241 ++ + I QHR+LEDR+SAA++L Q P C +V+D M NS + YGA ERLYV+Q+G Sbjct: 164 AFKNN-FDINQHRNLEDRLSAAQILVQKDPLCPVVVDDMNNSCAIKYGALPERLYVLQAG 222 Query: 242 TIMYQGGRGPDGYQVSELRTWLE 264 ++Y+G GP GY E+R++LE Sbjct: 223 KVLYKGAVGPWGYDPQEVRSYLE 245 >gb|ACX31205.1| deiodinase 1 [Ovis aries] Length = 146 Score = 143 bits (360), Expect = 7e-39 Identities = 73/140 (52%), Positives = 94/140 (67%), Gaps = 1/140 (0%) Query: 125 ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT 184 I D+ QG+RPLVLNFGSCT P F+ + F+RL+ ++ DFLIIYIEEAH SDGW Sbjct: 7 IWDFMQGNRPLVLNFGSCTUPSFIFKFDQFKRLIEEFGSVADFLIIYIEEAHASDGWAFK 66 Query: 185 DSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIM 244 ++ I HR+L+DR+ AA +L +P C +V+DTM N SSS Y A ERLYV+Q G I+ Sbjct: 67 NN-VDIKNHRNLQDRLRAAHLLLDRSPQCPVVVDTMKNQSSSCYAALPERLYVLQEGRIL 125 Query: 245 YQGGRGPDGYQVSELRTWLE 264 Y+G GP Y E+R LE Sbjct: 126 YKGKPGPWNYHPEEVRAVLE 145 >ref|NP_001007284.2| type I iodothyronine deiodinase [Danio rerio] gb|AAI55743.1| Deiodinase, iodothyronine, type I [Danio rerio] Length = 254 Score = 146 bits (368), Expect = 8e-39 Identities = 79/181 (43%), Positives = 116/181 (64%), Gaps = 2/181 (1%) Query: 84 TLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT 143 +LA +K ++ +A EG AP+S +I D Q + + +G+RPLVL+FGSCT Sbjct: 73 SLAFIKTLFFVNWCSLGLEAFEGHAAPDSALITLDR-QKTSVHRFLKGNRPLVLSFGSCT 131 Query: 144 *PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAA 203 PPF+ ++ F++LV + DFLI+Y+ EAH +D W ++ I H++LE+R++AA Sbjct: 132 UPPFLYKLDEFKQLVKDFSNVADFLIVYLAEAHATDAWAFKNN-VDISVHKNLEERLAAA 190 Query: 204 RVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWL 263 R L + P C +V+D M N ++S YGA ERLYVIQSG ++YQGG GP GY+ E+R L Sbjct: 191 RTLLKEDPPCPVVVDEMNNITASKYGALPERLYVIQSGKVIYQGGIGPWGYKPEEVRKVL 250 Query: 264 E 264 E Sbjct: 251 E 251 >gb|ADD82413.1| iodothyronine deiodinase type 2 [Chrysiptera cyanea] Length = 271 Score = 146 bits (369), Expect = 8e-39 Identities = 80/212 (37%), Positives = 122/212 (57%), Gaps = 28/212 (13%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-PDGFQSQ---------------- 123 R+ T L+++W+ LD +KQ G APNS+V++ PDG + Sbjct: 54 RMLTSEGLRSIWNSFLLDAYKQVKLGCEAPNSKVVKVPDGPRWSSAISSTTSVPCGAKIQ 113 Query: 124 -----RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPS 178 R+LD+ RPLV+NFGS T PPF++ + AF++LV + DF+++YI+EAHPS Sbjct: 114 NGDECRLLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFVLVYIDEAHPS 173 Query: 179 DGWVTT---DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYF 232 DGWV ++ +H++LE+R+ AAR L + P C LV D M N+++ AYG Sbjct: 174 DGWVAPPMGSCSFSFRKHQNLEERMGAARKLIEHFSLPPQCQLVADCMDNNANVAYGVSN 233 Query: 233 ERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 ER+ ++Q + Y GG+GP Y + ++R WLE Sbjct: 234 ERVCIVQQRKVAYLGGKGPFFYSLKDVRQWLE 265 >ref|XP_001628745.1| predicted protein [Nematostella vectensis] gb|EDO36682.1| predicted protein [Nematostella vectensis] Length = 194 Score = 143 bits (361), Expect = 2e-38 Identities = 75/184 (40%), Positives = 111/184 (60%), Gaps = 1/184 (0%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPF 147 L+ VW +D K+ A NS ++ R+LD+A+G RPLV+NFGS T P F Sbjct: 12 LENVWRSILVDMNKKVKLDNKAFNSPLVSLSDEGFCRLLDFAKGDRPLVVNFGSSTCPIF 71 Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M +M +++++ +++ DF+I+YIEEAHPSDGW D IP H S +R AAR L Sbjct: 72 MKKMLEYEKMIVQFKDVADFVIVYIEEAHPSDGW-AFDENNNIPTHSSQTERCVAARQLS 130 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHYD 267 C +++D+M N+++ AYGA RLY+I++ ++YQGG GP GY + ++ WL Y Sbjct: 131 SQNAICPVLVDSMLNAANVAYGALPIRLYIIRNNHVVYQGGAGPMGYCMDDVINWLSAYT 190 Query: 268 EQLH 271 Q H Sbjct: 191 CQKH 194 >ref|NP_001129617.1| iodothyronine deiodinase type II [Takifugu rubripes] dbj|BAG12772.1| iodothyronine deiodinase type II [Takifugu rubripes] Length = 270 Score = 145 bits (366), Expect = 2e-38 Identities = 80/210 (38%), Positives = 121/210 (57%), Gaps = 27/210 (12%) Query: 82 LCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR-PDGFQSQRI--------------- 125 + T A L+++W+ LD +KQ G APNS++++ PDG + I Sbjct: 55 MLTSAGLRSIWNSFLLDAYKQVKLGCEAPNSKLVKVPDGARWSSINNITNMLPGASLCNG 114 Query: 126 -----LDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG 180 LD+ +RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPSDG Sbjct: 115 IECHLLDFESSNRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDG 174 Query: 181 WVTTDS---PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFER 234 W + + +H++LE+R+ AA+ L + P C LV D M N+++ AYG ER Sbjct: 175 WKAPPMGPISFNVRKHQNLEERIGAAQKLIEHFSLPPQCQLVADCMDNNANVAYGVSNER 234 Query: 235 LYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + ++Q I Y GG+GP Y + E+R WLE Sbjct: 235 VCIVQQRKITYLGGKGPFFYNLKEVRQWLE 264 >ref|XP_003770386.1| PREDICTED: type I iodothyronine deiodinase [Sarcophilus harrisii] Length = 330 Score = 146 bits (369), Expect = 3e-38 Identities = 79/163 (48%), Positives = 105/163 (64%), Gaps = 2/163 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 QA +GG APNS V+ G +S+RI D+ +RPLVLNFGSCT P FM + FQ+L+ + Sbjct: 81 QALQGGLAPNSPVVTLSG-ESRRIWDFMNDNRPLVLNFGSCTXPSFMFKFGQFQKLIEDF 139 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMA 221 DFLIIYIEEAH +DGW ++ I QHR+L +R+ A+ L+ P C +VLDTM Sbjct: 140 SSIADFLIIYIEEAHAADGWAFANN-IEIRQHRTLRERMEASWRLRDKKPMCPVVLDTMD 198 Query: 222 NSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 N +S +Y A ER YV+ G I+++GG GP Y E+R LE Sbjct: 199 NLTSRSYAALPERFYVLLEGRILFKGGPGPWHYDPEEVRKVLE 241 >gb|ACX31203.1| deiodinase 2, partial [Cricetus cricetus] Length = 244 Score = 144 bits (363), Expect = 3e-38 Identities = 82/201 (40%), Positives = 116/201 (57%), Gaps = 20/201 (9%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQ-----------RIL 126 R+ T L+ VW LD +KQ G APNS V+ P+ + +L Sbjct: 44 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVPNPEAGSNYALEKTADWAECHLL 103 Query: 127 DYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTTD 185 D+A RPLV+NFGS T PPF ++ AF++LV ++ DFL++YI+EAHPSDGW V D Sbjct: 104 DFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGD 163 Query: 186 S--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQS 240 S + + +HRS EDR +AA L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 164 SSLSFEVKKHRSQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQR 223 Query: 241 GTIMYQGGRGPDGYQVSELRT 261 I Y GG+GP Y + E+R+ Sbjct: 224 QKIAYLGGKGPFSYNLQEVRS 244 >gb|ABM47422.1| iodothyronine type II deiodinase [Xenopus (Silurana) tropicalis] Length = 197 Score = 141 bits (355), Expect = 1e-37 Identities = 75/190 (39%), Positives = 112/190 (58%), Gaps = 14/190 (7%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRI----------LDYAQ 130 R+ T L+ VW+ LD +KQ G APNS VI+ + + LD+A Sbjct: 7 RMLTPEGLRCVWNSFLLDAYKQVKLGQDAPNSNVIQVSNKICKSVQRKLVGKCHLLDFAS 66 Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT-DSPYT 189 RPLV+NFGS T PPF++++ AF +LV ++ DF+++YI+EAHPSDGW + Y Sbjct: 67 SERPLVVNFGSATUPPFISQLPAFSKLVEEFSSVADFVLVYIDEAHPSDGWAAPGTTSYE 126 Query: 190 IPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQ 246 + +HR+ E+R +AA L + P C +V D M N+++ AYG FER+ ++Q I+Y Sbjct: 127 VKKHRNQEERCAAASKLLEHFSIPPQCQVVADCMDNNANVAYGVSFERVCIVQKQKIVYL 186 Query: 247 GGRGPDGYQV 256 GG+GP Y + Sbjct: 187 GGKGPFFYNI 196 >gb|AAR25890.1| iodothyronine deiodinase [Halocynthia roretzi] Length = 259 Score = 142 bits (359), Expect = 2e-37 Identities = 76/187 (40%), Positives = 107/187 (57%), Gaps = 5/187 (2%) Query: 78 DDNRLCTLASLKAVWHGQK----LDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 D +R + SL+ V+H K D + A GG APNS ++ + ILD+ + R Sbjct: 63 DLSRDPAMQSLRGVYHMAKSILYADVLRTAVRGGNAPNSSLVNYRTKEKCNILDFMKPGR 122 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLV+NFGSC+ PPFMA F R++ Y DFL +YIEEAH SD W ++ Y+IP H Sbjct: 123 PLVVNFGSCSUPPFMASFEIFSRIIDSYHERADFLTVYIEEAHSSDLWALKNNKYSIPSH 182 Query: 194 RSLEDRVSAARVLQQGAP-GCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPD 252 + EDR+ AA + ++ CA +DTM + ++ +YGA ER +I G + Y GG GP Sbjct: 183 ITFEDRMEAAAIFKKSVSFECAFAVDTMKDETNLSYGALPERTAIILDGKVQYIGGIGPF 242 Query: 253 GYQVSEL 259 Y + EL Sbjct: 243 NYDLVEL 249 >gb|ADD82414.1| iodothyronine deiodinase type 1 [Chrysiptera cyanea] Length = 248 Score = 142 bits (358), Expect = 2e-37 Identities = 73/164 (44%), Positives = 111/164 (67%), Gaps = 2/164 (1%) Query: 101 KQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTK 160 ++A G AP++ V +G + I Y +G+RPLVL+FGS T PPFM ++ F++LV Sbjct: 84 QEAFRGQLAPDTPVFTMEG-EKTSICKYIKGNRPLVLSFGSRTUPPFMYKLEEFKQLVKD 142 Query: 161 YQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTM 220 + DFL++YI EAH +DGW T++ I QH+SLE+R+SAA++L Q P C +V+D M Sbjct: 143 FSDVADFLVVYIAEAHSTDGWAFTNN-IDINQHQSLEERMSAAKILIQEDPLCPVVVDDM 201 Query: 221 ANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 +N ++ YGA ERLYV+ +G ++Y+G GP GY E+R++L+ Sbjct: 202 SNITAIKYGALPERLYVLHAGKVVYKGTEGPWGYSPPEVRSFLQ 245 >emb|CAP16957.1| putative thyroxine 5'-deiodinase [Solea senegalensis] Length = 205 Score = 140 bits (352), Expect = 5e-37 Identities = 78/199 (39%), Positives = 115/199 (57%), Gaps = 23/199 (11%) Query: 89 KAVWHGQKLDFFKQAHEGGPAPNSEVIR-PDGFQSQ----------------RILDYAQG 131 + +W+ LD KQ G APNS+V+ P G +S +LD+ Sbjct: 1 RCIWNSFLLDAHKQVKLGHEAPNSKVVVVPGGPRSNATTLPNAARTRNGDECHLLDFESL 60 Query: 132 SRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT---DSPY 188 RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPSDGWV S + Sbjct: 61 DRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAPPMGSSSF 120 Query: 189 TIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMY 245 + +H++LE+R+ AAR L + P C LV D M N+++ AYG ER+ ++Q I Y Sbjct: 121 NVRKHQNLEERLGAARKLTEHFSLPPQCRLVADCMDNNANVAYGVANERVCIVQHKKIAY 180 Query: 246 QGGRGPDGYQVSELRTWLE 264 GG+GP Y + +++ WLE Sbjct: 181 LGGKGPFFYSLKDVQQWLE 199 >ref|XP_003891983.1| PREDICTED: type I iodothyronine deiodinase [Papio anubis] Length = 303 Score = 142 bits (358), Expect = 7e-37 Identities = 81/173 (46%), Positives = 106/173 (61%), Gaps = 5/173 (2%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + GG APN V+R G Q I D+ QG+R Sbjct: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSG-QRCNIWDFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQH 193 PLVLNFGSCT P FM + F+RL+ ++ DFLIIYIEEAH SDGW ++ I H Sbjct: 116 PLVLNFGSCTXPSFMFKFDQFKRLIEDFRSIADFLIIYIEEAHASDGWAFKNN-MDIRNH 174 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQ 246 ++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVIQ G I+Y+ Sbjct: 175 QNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVIQEGRILYK 227 >emb|CAG10462.1| unnamed protein product [Tetraodon nigroviridis] Length = 129 Score = 135 bits (340), Expect = 4e-36 Identities = 70/140 (50%), Positives = 88/140 (62%), Gaps = 13/140 (9%) Query: 4 SLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSE 63 SL++++++ VL PRFL A M WLLDFLCIRK R + Sbjct: 3 SLMMNTMKSIKNALVFFVLLPRFLMAAVMFWLLDFLCIRKRVFFRM-------------K 49 Query: 64 GEEVPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQ 123 +E A DPP+C+SD NRL T+ SLKAVWHG KLDF K AH G APN+EV++ + + Sbjct: 50 EQEDDAVDPPLCISDSNRLFTVESLKAVWHGHKLDFLKAAHLGQGAPNTEVVQLEDQRRS 109 Query: 124 RILDYAQGSRPLVLNFGSCT 143 RILDYA+ RPL+LNFGSCT Sbjct: 110 RILDYAKDKRPLILNFGSCT 129 >gb|ACO57581.1| iodothyronine deiodinase type I [Gillichthys seta] Length = 206 Score = 137 bits (346), Expect = 4e-36 Identities = 72/153 (47%), Positives = 102/153 (66%), Gaps = 2/153 (1%) Query: 84 TLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT 143 +L+ +K L ++A EG PAP+S V+ +G +S I + + +RPLVLNFGSCT Sbjct: 56 SLSFIKVASRHMWLSMGQEAFEGWPAPDSPVVTMEGHESS-IFKFMKDNRPLVLNFGSCT 114 Query: 144 *PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAA 203 PPFM ++ F+ LV ++ DFL++YI EAH SDGW +++ Y I QH+SLEDR+SAA Sbjct: 115 UPPFMFKLGEFKELVQDFREVADFLVVYIAEAHSSDGWAFSNN-YDINQHQSLEDRLSAA 173 Query: 204 RVLQQGAPGCALVLDTMANSSSSAYGAYFERLY 236 R+L Q P C +V+D M+N ++ YGA ERLY Sbjct: 174 RILVQKDPLCPVVVDEMSNCAAINYGALPERLY 206 >gb|ACO57580.1| iodothyronine deiodinase type I [Gillichthys mirabilis] Length = 206 Score = 137 bits (346), Expect = 4e-36 Identities = 78/177 (44%), Positives = 109/177 (61%), Gaps = 4/177 (2%) Query: 62 SEGEEVPADDPPICVSDDNRLC--TLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDG 119 S GE+ P +D L +L+ +K L + A EG PAP+S V+ +G Sbjct: 32 SMGEKFTMTQNPSFTFEDWGLTFISLSFIKVASRHMWLSMGQDAFEGRPAPDSPVVTMEG 91 Query: 120 FQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSD 179 +S I + + +RPLVLNFGSCT PPFM ++ F+ LV ++ DFL++YI EAH SD Sbjct: 92 HESS-IFKFMKDNRPLVLNFGSCTUPPFMFKLGEFKELVQDFREVADFLVVYIAEAHSSD 150 Query: 180 GWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLY 236 GW +++ Y I QH+SLEDR+SAAR+L Q P C +V+D M+N ++ YGA ERLY Sbjct: 151 GWAFSNN-YDINQHQSLEDRLSAARILVQKDPLCPVVVDEMSNCAAIKYGALPERLY 206 >emb|CCD22053.1| putative iodothyronine deiodinase type 2.2, partial [Cyprinus carpio] Length = 178 Score = 135 bits (341), Expect = 1e-35 Identities = 69/172 (40%), Positives = 105/172 (61%), Gaps = 17/172 (9%) Query: 110 PNSEVIRPDGFQ-----------SQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLV 158 PNS+V++ G +LD+ RPLV+NFGS T PPF++++ F+R+V Sbjct: 1 PNSKVVKVPGINRCWSISGKTHNECHLLDFESPDRPLVVNFGSATUPPFISQLPVFRRMV 60 Query: 159 TKYQRDVDFLIIYIEEAHPSDGWVT---TDSPYTIPQHRSLEDRVSAARVLQQG---APG 212 ++ DFL++YI+EAHPSDGWV + + + +HR+LE+R+ AAR L + P Sbjct: 61 EEFSDVADFLLVYIDEAHPSDGWVAPPMENFSFEVRKHRNLEERMFAARTLLEHFSLPPQ 120 Query: 213 CALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 C LV D M N+++ AYG +ER+ ++Q I Y GG+GP Y + ++R WLE Sbjct: 121 CQLVADCMDNNTNVAYGVAYERVCIVQKNKIAYLGGKGPFFYNLKDVRHWLE 172 >ref|NP_998758.1| type I iodothyronine deiodinase isoform b [Homo sapiens] gb|AAT02481.1| type I iodothyronine deiodinase splice variant b [Homo sapiens] Length = 185 Score = 135 bits (340), Expect = 2e-35 Identities = 68/134 (50%), Positives = 88/134 (65%), Gaps = 1/134 (0%) Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTI 190 G+RPLVLNFGSCT P FM + F+RL+ + DFL+IYIEEAH SDGW ++ I Sbjct: 49 GNRPLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNN-MDI 107 Query: 191 PQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRG 250 H++L+DR+ AA +L +P C +V+DTM N SS Y A ERLY+IQ G I+Y+G G Sbjct: 108 RNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSG 167 Query: 251 PDGYQVSELRTWLE 264 P Y E+R LE Sbjct: 168 PWNYNPEEVRAVLE 181 >ref|XP_003787003.1| PREDICTED: LOW QUALITY PROTEIN: type II iodothyronine deiodinase-like [Otolemur garnettii] Length = 307 Score = 138 bits (348), Expect = 2e-35 Identities = 101/286 (35%), Positives = 140/286 (48%), Gaps = 44/286 (15%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLA-----SLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---P 117 + PP +S D ++ LA S V+ L K E APNS V+ P Sbjct: 72 YKQLNCPPSGLSKDGQILXLAYEAYRSRLLVYSYLDLQMVKLGEE---APNSSVVHVSNP 128 Query: 118 DGFQSQ-------------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRD 164 + S +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 129 EKGDSSGNGAPENAAGAECHLLDFASPERPLVVNFGSATXPPFTSQLPAFRKLVEEFSAV 188 Query: 165 VDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLD 218 DFL++YI+EAHPSDGW V DS + + +HR+ EDR +AA L + P C +V D Sbjct: 189 ADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCRVVAD 248 Query: 219 TMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 249 RMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFFYNLQEVRRWLE 294 >ref|XP_003924661.1| PREDICTED: type II iodothyronine deiodinase [Saimiri boliviensis boliviensis] Length = 308 Score = 138 bits (347), Expect = 3e-35 Identities = 97/288 (33%), Positives = 139/288 (48%), Gaps = 48/288 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEG----------EE 66 L + P F L L D + + KH L R E L SEG + Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 67 VPADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHE-------GGPAPNSEVIRPDG 119 + P S+D + L V+ K +H G APNS V+R G Sbjct: 72 YKQQNCPSGFSNDGHILXL-----VYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVRVSG 126 Query: 120 FQSQ-----------------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQ 162 + +LD+A RPLV+NFGS T PPF +++ AF +LV ++ Sbjct: 127 AEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATXPPFTSQLPAFCKLVEEFS 186 Query: 163 RDVDFLIIYIEEAHPSDGW-VTTDSPYT--IPQHRSLEDRVSAARVLQQG---APGCALV 216 DFL++YI+EAHPSDGW + DS ++ + +H+S EDR +AA+ L + P C +V Sbjct: 187 SVADFLLVYIDEAHPSDGWAIPGDSSWSFEVKKHQSQEDRCAAAQKLLERFSLPPQCRVV 246 Query: 217 LDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 ADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 294 >ref|XP_001641736.1| predicted protein [Nematostella vectensis] gb|EDO49673.1| predicted protein [Nematostella vectensis] Length = 171 Score = 134 bits (336), Expect = 4e-35 Identities = 74/165 (44%), Positives = 102/165 (61%), Gaps = 2/165 (1%) Query: 101 KQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTK 160 K A G APN E+ DG S R+LD+AQ PLV+NFGS T P F AR+ F LV Sbjct: 8 KPAICGLEAPNPELFSVDGSVSFRLLDFAQDGMPLVVNFGSYTCPVFRARLGEFGELVES 67 Query: 161 YQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAA-RVLQQGAPGCALVLDT 219 ++ F+ +Y++EAHP+D W ++ TI QH+SL +R AA ++L L++DT Sbjct: 68 FKATAKFVTVYVKEAHPTDEWFLKNNE-TIRQHKSLMERCDAAKKLLGTKTLRTPLLVDT 126 Query: 220 MANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 M N+++ AYGA RLY+IQSG + Y GG GP Y+ E++ WLE Sbjct: 127 MENAANEAYGAVPTRLYIIQSGIVQYAGGIGPTFYRPWEVKKWLE 171 >gb|AFR11377.1| deiodinase 2, partial [Ovis aries] Length = 195 Score = 133 bits (335), Expect = 1e-34 Identities = 76/182 (41%), Positives = 107/182 (58%), Gaps = 23/182 (12%) Query: 106 GGPAPNSEVI---RPDGFQSQ--------------RILDYAQGSRPLVLNFGSCT*PPFM 148 G APNS V+ P+G + +LD+A RPLV+NFGS T PPF Sbjct: 4 GEDAPNSRVVPVSSPEGGDTAGNDAQEKTADGTECHLLDFASPERPLVVNFGSATUPPFT 63 Query: 149 ARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTTDSP--YTIPQHRSLEDRVSAARV 205 ++ AF +LV ++ DFL++YI+EAHPSDGW V DS + + +HR+ EDR +AA+ Sbjct: 64 NQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVXGDSSLFFEVKKHRNQEDRCAAAQQ 123 Query: 206 LQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTW 262 L + P C +V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R W Sbjct: 124 LLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFFYNLQEVRRW 183 Query: 263 LE 264 LE Sbjct: 184 LE 185 >emb|CAO02453.1| deiodinase iodothyronine type II [Tremarctos ornatus] Length = 170 Score = 132 bits (332), Expect = 2e-34 Identities = 70/158 (44%), Positives = 102/158 (64%), Gaps = 7/158 (4%) Query: 112 SEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIY 171 ++V DG + +LD+A+ RPLV+NFGS T PPF +++ AF +LV ++ DFL++Y Sbjct: 14 AQVTMVDGAECH-LLDFARPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVY 72 Query: 172 IEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSS 225 I+EAHPSDGW V DS + + +HR+ EDR +AA L + P C +V D M N+++ Sbjct: 73 IDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLEHFSLPPQCRVVADRMDNNAN 132 Query: 226 SAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWL 263 AYG FER+ ++Q I Y GG+GP Y + E+R WL Sbjct: 133 VAYGVAFERVCIVQRQKIAYLGGKGPFCYNLQEVRRWL 170 >ref|XP_003734100.1| PREDICTED: LOW QUALITY PROTEIN: type II iodothyronine deiodinase [Callithrix jacchus] Length = 309 Score = 135 bits (341), Expect = 2e-34 Identities = 96/289 (33%), Positives = 138/289 (47%), Gaps = 49/289 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEG-------GPAPNSEVIRPD 118 + PP S+D + L V+ K +H G APNS V+ Sbjct: 72 YKQLNCPPSGFSNDGXILXL-----VYEAYKSKLLVYSHLGLWMVKLGEDAPNSSVVHVS 126 Query: 119 GFQSQ-----------------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 G + +LD+A RPLV+NFGS T PPF +++ AF +LV ++ Sbjct: 127 GAEGGDDSGNGTQEKIAEGAACHLLDFASPERPLVVNFGSATXPPFTSQLPAFCKLVEEF 186 Query: 162 QRDVDFLIIYIEEAHPSDGW-VTTDSPYT--IPQHRSLEDRVSAARVLQQG---APGCAL 215 DFL++YI+EAHPSDGW + DS ++ + +H++ EDR +AA+ L + P C + Sbjct: 187 SSVADFLLVYIDEAHPSDGWAIPGDSSWSFEVKKHQNQEDRCAAAQKLLERFSLPPQCRV 246 Query: 216 VLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 VADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 295 >emb|CAO02448.1| deiodinase iodothyronine type II [Ursus arctos] emb|CAO02449.1| deiodinase iodothyronine type II [Ursus americanus] emb|CAO02451.1| deiodinase iodothyronine type II [Melursus ursinus] Length = 170 Score = 132 bits (331), Expect = 2e-34 Identities = 70/158 (44%), Positives = 101/158 (63%), Gaps = 7/158 (4%) Query: 112 SEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIY 171 ++V DG + +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++Y Sbjct: 14 AQVTMVDGAECH-LLDFASPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVY 72 Query: 172 IEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSS 225 I+EAHPSDGW V DS + + +HR+ EDR +AA L + P C +V D M N+++ Sbjct: 73 IDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLEHFSLPPQCRVVADRMDNNAN 132 Query: 226 SAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWL 263 AYG FER+ ++Q I Y GG+GP Y + E+R WL Sbjct: 133 VAYGVAFERVCIVQRQKIAYLGGKGPFCYNLQEVRRWL 170 >ref|NP_001116109.1| type II iodothyronine deiodinase isoform 1 [Pan troglodytes] Length = 309 Score = 135 bits (340), Expect = 3e-34 Identities = 97/289 (33%), Positives = 140/289 (48%), Gaps = 49/289 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHE-------GGPAPNSEVIRP- 117 + PP S D + L V+ K +H G APNS V+ Sbjct: 72 YKQLNCPPSGFSKDGHILUL-----VYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVS 126 Query: 118 ---------DGFQSQ-------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +G Q + +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 127 SAEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEF 186 Query: 162 QRDVDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCAL 215 DFL++YI+EAHPSDGW + DS + + +H++ EDR +AA+ L + P C + Sbjct: 187 SSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRV 246 Query: 216 VLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 V D+M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 VADSMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 295 >gb|ACZ37063.1| deiodinase type III [Cyclorana alboguttata] Length = 82 Score = 128 bits (322), Expect = 4e-34 Identities = 54/82 (65%), Positives = 73/82 (89%) Query: 170 IYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYG 229 +YIEEAHPSDGWV+TD+ Y IP+H+SL+DR+ AA+++ QG PGC +V+DTM+N+S++AYG Sbjct: 1 LYIEEAHPSDGWVSTDASYQIPKHQSLQDRLRAAQLMLQGVPGCRVVVDTMSNASNAAYG 60 Query: 230 AYFERLYVIQSGTIMYQGGRGP 251 AYFERLY+I G ++YQGGRGP Sbjct: 61 AYFERLYIIVDGKVVYQGGRGP 82 >ref|XP_003808941.1| PREDICTED: type II iodothyronine deiodinase [Pan paniscus] Length = 309 Score = 134 bits (338), Expect = 6e-34 Identities = 97/289 (33%), Positives = 139/289 (48%), Gaps = 49/289 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHE-------GGPAPNSEVIRP- 117 + PP S D + L V+ K +H G APNS V+ Sbjct: 72 YKQLNCPPSGFSKDGHILXL-----VYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVS 126 Query: 118 ---------DGFQSQ-------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +G Q + +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 127 SAEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATXPPFTSQLPAFRKLVEEF 186 Query: 162 QRDVDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCAL 215 DFL++YI+EAHPSDGW + DS + + +H++ EDR +AA+ L + P C + Sbjct: 187 SSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRV 246 Query: 216 VLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 VADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 295 >ref|NP_001007024.1| type II iodothyronine deiodinase isoform b [Homo sapiens] Length = 309 Score = 134 bits (338), Expect = 6e-34 Identities = 97/289 (33%), Positives = 139/289 (48%), Gaps = 49/289 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHE-------GGPAPNSEVIRP- 117 + PP S D + L V+ K +H G APNS V+ Sbjct: 72 YKQLNCPPSGFSKDGHILUL-----VYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVS 126 Query: 118 ---------DGFQSQ-------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +G Q + +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 127 STEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEF 186 Query: 162 QRDVDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCAL 215 DFL++YI+EAHPSDGW + DS + + +H++ EDR +AA+ L + P C + Sbjct: 187 SSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRV 246 Query: 216 VLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 VADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 295 >ref|XP_001636571.1| predicted protein [Nematostella vectensis] gb|EDO44508.1| predicted protein [Nematostella vectensis] Length = 256 Score = 133 bits (334), Expect = 7e-34 Identities = 72/193 (37%), Positives = 111/193 (57%), Gaps = 6/193 (3%) Query: 87 SLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PP 146 SLKA +L+ ++A G APN ++ DG + +LD+ +GSRPL++N GSCT P Sbjct: 64 SLKAHLEMIQLELQREAVPGKIAPNPPLVSLDGKEKSHLLDHVRGSRPLIVNLGSCTCPV 123 Query: 147 FMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVL 206 FM R S F+++V ++ DF +YI+EAHPSD W + I Q R++++R AA+ L Sbjct: 124 FMKRQSEFKKIVEEFMSVADFATVYIKEAHPSDEW-KFEGNIEIQQPRTIQERCRAAQKL 182 Query: 207 QQ---GAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWL 263 ++ P L++DTM N ++ ++ RLY+I G + Y GG GP Y ++ WL Sbjct: 183 KELNKLHPSSRLLVDTMENLANKSFAGLPTRLYIIHDGRVQYAGGMGPTFYHTQDIMQWL 242 Query: 264 EHYDEQLHGTRPR 276 Y ++ TR R Sbjct: 243 AEYKKK--STRQR 253 >ref|XP_002825039.2| PREDICTED: type II iodothyronine deiodinase [Pongo abelii] Length = 309 Score = 134 bits (337), Expect = 8e-34 Identities = 97/289 (33%), Positives = 139/289 (48%), Gaps = 49/289 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHE-------GGPAPNSEVIRP- 117 + PP S D + L V+ K +H G APNS V+ Sbjct: 72 YKQLNCPPSGFSKDGHILXL-----VYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVS 126 Query: 118 ---------DGFQSQ-------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +G Q + +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 127 SAEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATXPPFTSQLPAFRKLVEEF 186 Query: 162 QRDVDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCAL 215 DFL++YI+EAHPSDGW + DS + + +H++ EDR +AA+ L + P C + Sbjct: 187 SSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRV 246 Query: 216 VLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 VADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLHEVRHWLE 295 >ref|NP_001152766.1| type II iodothyronine deiodinase [Macaca mulatta] Length = 309 Score = 134 bits (337), Expect = 8e-34 Identities = 97/289 (33%), Positives = 138/289 (47%), Gaps = 49/289 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHE-------GGPAPNSEVIRPD 118 + PP S D + L V+ K +H G APNS V+ Sbjct: 72 YKQLNCPPSGFSKDGHILUL-----VYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVS 126 Query: 119 ----------GFQSQ-------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 G Q + +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 127 SAEGGDNSGHGTQEKIAEGAACHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEF 186 Query: 162 QRDVDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCAL 215 DFL++YI+EAHPSDGW + DS + + +H++ EDR +AA+ L + P C + Sbjct: 187 SSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRV 246 Query: 216 VLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 VADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 295 >ref|XP_003987942.1| PREDICTED: type II iodothyronine deiodinase [Felis catus] Length = 315 Score = 134 bits (336), Expect = 1e-33 Identities = 76/182 (41%), Positives = 107/182 (58%), Gaps = 23/182 (12%) Query: 106 GGPAPNSEVIR---PDGFQSQR--------------ILDYAQGSRPLVLNFGSCT*PPFM 148 G APNS V+ +G + R +LD+A RPLV+NFGS T PPF Sbjct: 121 GEDAPNSSVVHVSNSEGGDNSRNGAQVKIVDGGECHLLDFASPERPLVVNFGSATXPPFT 180 Query: 149 ARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARV 205 +++ AF +LV ++ DFL++YI+EAHPSDGW V DS + + +HR+ EDR +AA Sbjct: 181 SQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQ 240 Query: 206 LQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTW 262 L + P C +V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R W Sbjct: 241 LLEHFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAYLGGKGPFYYNLQEVRRW 300 Query: 263 LE 264 LE Sbjct: 301 LE 302 >ref|XP_003902172.1| PREDICTED: LOW QUALITY PROTEIN: type II iodothyronine deiodinase-like [Papio anubis] Length = 309 Score = 133 bits (334), Expect = 2e-33 Identities = 97/285 (34%), Positives = 138/285 (48%), Gaps = 41/285 (14%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTL---ASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPD---- 118 + PP S D + L A + LD + G APNS V+ Sbjct: 72 YKQLNCPPSGFSKDGHILXLVYEAYKSRLLVYSPLDLW-MVKLGEDAPNSSVVHVSSAEG 130 Query: 119 ------GFQSQ-------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDV 165 G Q + +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 131 GDNSGHGTQEKIAEGAACHLLDFASPERPLVVNFGSATXPPFTSQLPAFRKLVEEFSSVA 190 Query: 166 DFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDT 219 DFL++YI+EAHPSDGW + DS + + +H++ EDR +AA+ L + P C +V D Sbjct: 191 DFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADR 250 Query: 220 MANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 251 MDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 295 >dbj|BAB16838.1| type II iodothyronine deiodinase [Homo sapiens] Length = 309 Score = 132 bits (331), Expect = 6e-33 Identities = 96/289 (33%), Positives = 138/289 (47%), Gaps = 49/289 (16%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEV--------- 67 L + P F L L D + + KH L R E L SEG Sbjct: 12 LQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDA 71 Query: 68 --PADDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHE-------GGPAPNSEVIRP- 117 + PP S D + L V+ K +H G APNS V+ Sbjct: 72 YKQLNCPPSGFSKDGHILUL-----VYEAYKSRLLVYSHLDLWMVKLGEDAPNSSVVHVS 126 Query: 118 ---------DGFQSQ-------RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +G Q + +LD+A RPLV+NFGS T PPF +++ AF++LV ++ Sbjct: 127 STEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEF 186 Query: 162 QRDVDFLIIYIEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCAL 215 DFL++YI+EAHPSDGW + DS + + +H++ EDR +AA+ + P C + Sbjct: 187 SSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQPLERFSLPPQCRV 246 Query: 216 VLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 V D M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R WLE Sbjct: 247 VADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLE 295 >gb|AAO65268.1| iodothyronine deiodinase type I Deio1 [Danio rerio] Length = 241 Score = 128 bits (322), Expect = 3e-32 Identities = 69/163 (42%), Positives = 104/163 (63%), Gaps = 2/163 (1%) Query: 84 TLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT 143 +LA +K ++ +A EG AP+S +I D Q + + +G+RPLVL+FGSCT Sbjct: 73 SLAFIKTLFFVNWCSLGLEAFEGHAAPDSALITLDR-QKTSVHRFLKGNRPLVLSFGSCT 131 Query: 144 *PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAA 203 PPF+ ++ F++LV + DFLI+Y+ EAH +D W ++ I H++LE+R++AA Sbjct: 132 UPPFLYKLDEFKQLVKDFSNVADFLIVYLAEAHATDAWAFKNN-VDISVHKNLEERLAAA 190 Query: 204 RVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQ 246 R L + P C +V+D M N ++S YGA ERLYVIQSG ++YQ Sbjct: 191 RTLLKEDPPCPVVVDEMNNITASKYGALPERLYVIQSGKVIYQ 233 >gb|ADH94050.1| type II iodothyronine deiodinase [Halichoeres trimaculatus] Length = 177 Score = 126 bits (316), Expect = 4e-32 Identities = 62/146 (42%), Positives = 94/146 (64%), Gaps = 6/146 (4%) Query: 125 ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT 184 +LD+ RPLV+NFGS T PPF++ + +F +LV + DFL++YI+EAHPSDGWV Sbjct: 26 LLDFETSDRPLVVNFGSATUPPFISHLPSFGQLVEDFSDVADFLLVYIDEAHPSDGWVAP 85 Query: 185 ---DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVI 238 + + +H++LE+R+ AAR L + P C LV D++ N+++ AYG ER+ ++ Sbjct: 86 PMGSCSFDVRKHQNLEERLGAARKLIEHFSLPPQCQLVADSVDNNANVAYGVSNERVCIV 145 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q I Y GG+GP Y + ++R WLE Sbjct: 146 QQRKIAYLGGKGPFFYNLKDVRQWLE 171 >gb|ABY40369.1| iodothyronine deiodinase type III, partial [Carassius auratus] Length = 104 Score = 124 bits (310), Expect = 4e-32 Identities = 63/117 (53%), Positives = 76/117 (64%), Gaps = 16/117 (13%) Query: 34 WLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDDNRLCTLASLKAVWH 93 WLLDFLCIR+ L + P DDPP+CVSD N++ TL SL+AVW+ Sbjct: 1 WLLDFLCIRRKVLTKMRESDLSP-------------DDPPLCVSDSNKMFTLESLRAVWY 47 Query: 94 GQKLDFFKQAHEGGPAPNSEVIRPDGFQ---SQRILDYAQGSRPLVLNFGSCT*PPF 147 G KLDFFK A GG APN+EV+ D +QRILDYA+G RPL+LNFGSC+ PPF Sbjct: 48 GHKLDFFKTARLGGAAPNTEVVPLDSASRRGAQRILDYARGRRPLILNFGSCSUPPF 104 >dbj|BAI43476.1| type II iodothyronine deiodinase [Mesocricetus auratus] Length = 234 Score = 126 bits (317), Expect = 1e-31 Identities = 74/180 (41%), Positives = 103/180 (57%), Gaps = 22/180 (12%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---------------PDGFQSQRI 125 R+ T L+ VW LD +KQ G APNS V+ DG + + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGNNYALEKTADGAECH-L 111 Query: 126 LDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTT 184 LD+A RPLV+NFGS T PPF ++ AF++LV ++ DFL++YI+EAHPSDGW V Sbjct: 112 LDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPG 171 Query: 185 DS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQ 239 DS + + +HRS EDR +AA L + P C +V D M N+++ AYG FER+ ++Q Sbjct: 172 DSSLSFEVKKHRSQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQ 231 >gb|AEX08671.1| deiodinase [Chlamys farreri] Length = 299 Score = 126 bits (316), Expect = 6e-31 Identities = 60/168 (35%), Positives = 100/168 (59%), Gaps = 1/168 (0%) Query: 100 FKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVT 159 F++ G APN+++ D +++ + + RPLVLNFGSC+ PPF+A++ + ++ Sbjct: 128 FRKTILGRKAPNTDLYDMDTKSYKKLYSFQKAGRPLVLNFGSCSUPPFIAKVEEMKTIIR 187 Query: 160 KYQRDVDFLIIYIEEAHPSDGWVTTDSPY-TIPQHRSLEDRVSAARVLQQGAPGCALVLD 218 + DFL IYI EAHP +GW + + H++L DRV+AA++L+ C +++D Sbjct: 188 DFADVADFLTIYIREAHPVEGWQVFGHRFEDMKDHKTLGDRVAAAKLLRDFDLKCPILID 247 Query: 219 TMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHY 266 M N ++ Y A ERLY++ T+MY G GP+ Y+ +R+WL + Sbjct: 248 PMDNQNAVQYAAVPERLYILYDNTVMYFGAVGPENYKPHAIRSWLNSF 295 >emb|CAO02450.1| deiodinase iodothyronine type II [Helarctos malayanus] emb|CAO02452.1| deiodinase iodothyronine type II [Ursus thibetanus] emb|CAO02454.1| deiodinase iodothyronine type II [Ailuropoda melanoleuca] Length = 163 Score = 122 bits (306), Expect = 9e-31 Identities = 66/151 (43%), Positives = 96/151 (63%), Gaps = 7/151 (4%) Query: 112 SEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIY 171 ++V DG + +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++Y Sbjct: 14 AQVTMVDGAECH-LLDFASPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVY 72 Query: 172 IEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSS 225 I+EAHPSDGW V DS + + +HR+ EDR +AA L + P C +V D M N+++ Sbjct: 73 IDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLEHFSLPPQCRVVADRMDNNAN 132 Query: 226 SAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 AYG FER+ ++Q I Y GG+GP Y + Sbjct: 133 VAYGVAFERVCIVQRQKIAYLGGKGPFCYNL 163 >emb|CAO02447.1| deiodinase iodothyronine type II [Ursus maritimus] Length = 163 Score = 122 bits (305), Expect = 1e-30 Identities = 66/151 (43%), Positives = 96/151 (63%), Gaps = 7/151 (4%) Query: 112 SEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIY 171 ++V DG + +LD+A RPLV+NFGS T PPF +++ AF +LV ++ DFL++Y Sbjct: 14 AQVTMVDGAKCH-LLDFASPERPLVVNFGSATUPPFTSQLPAFSKLVEEFSSVADFLLVY 72 Query: 172 IEEAHPSDGW-VTTDS--PYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSS 225 I+EAHPSDGW V DS + + +HR+ EDR +AA L + P C +V D M N+++ Sbjct: 73 IDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLEHFSLPPQCRVVADRMDNNAN 132 Query: 226 SAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 AYG FER+ ++Q I Y GG+GP Y + Sbjct: 133 VAYGVAFERVCIVQRQKIAYLGGKGPFCYNL 163 >gb|EHH28085.1| hypothetical protein EGK_18431 [Macaca mulatta] Length = 251 Score = 122 bits (305), Expect = 9e-30 Identities = 76/207 (36%), Positives = 109/207 (52%), Gaps = 37/207 (17%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPD----------GFQSQ------- 123 R+ T L+ VW LD +KQ G APNS V+ G Q + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSAEGGDNSGHGTQEKIAEGAAC 112 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLVL AF++LV ++ DFL++YI+EAHPSDGW + Sbjct: 113 HLLDFASPERPLVL--------------PAFRKLVEEFSSVADFLLVYIDEAHPSDGWAI 158 Query: 183 TTDSP--YTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYV 237 DS + + +H++ EDR +AA+ L + P C +V D M N+++ AYG FER+ + Sbjct: 159 PGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCI 218 Query: 238 IQSGTIMYQGGRGPDGYQVSELRTWLE 264 +Q I Y GG+GP Y + E+R WLE Sbjct: 219 VQRQKIAYLGGKGPFSYNLQEVRHWLE 245 >dbj|BAE54452.1| type II iodothyronine deiodinase [Anguilla japonica] Length = 187 Score = 117 bits (294), Expect = 8e-29 Identities = 69/161 (42%), Positives = 99/161 (61%), Gaps = 18/161 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVI-------RPDGFQSQ-----RILDY 128 R+ T A LK++W+ LD +KQ GG APNS+V+ R GF S+ +LD+ Sbjct: 27 RMLTSAGLKSIWNSFLLDAYKQVKLGGEAPNSKVVKVPSVSSRKLGFSSRTGDECNLLDF 86 Query: 129 AQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW---VTTD 185 A RPLV+NFGS T PPF++ + AF++LV ++ DFL++YI+EAHPSD W Sbjct: 87 ASSDRPLVVNFGSATUPPFISHLPAFRQLVEEFSDVADFLLVYIDEAHPSDIWAAPAVEA 146 Query: 186 SPYTIPQHRSLEDRVSAA-RVLQQGA--PGCALVLDTMANS 223 + + +HRSLE+RV AA R+L++ + C LV D M N+ Sbjct: 147 HSFKVQKHRSLEERVLAAQRLLERFSMPSQCQLVADCMDNN 187 >gb|EHB12960.1| Type II iodothyronine deiodinase [Heterocephalus glaber] Length = 238 Score = 116 bits (290), Expect = 1e-27 Identities = 70/193 (36%), Positives = 102/193 (52%), Gaps = 22/193 (11%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR---PDGFQSQRILDYAQGSRPLVL 137 R+ T L+ VW LD +KQ G APNS V+R P+G S G + Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVRVSSPEGAHSS-----GNGVQEKTA 107 Query: 138 NFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT---TDSPYTIPQHR 194 + + ++ AF +LV ++ DFL++YI+EAHPSDGW + + +HR Sbjct: 108 DG--------VHQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGGSSLSLEVKKHR 159 Query: 195 SLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGP 251 + EDR +AA L + P C +V D M N+++ AYG FER+ ++Q I Y GG+GP Sbjct: 160 NQEDRCAAAHQLLERFSLPPQCQVVADCMDNNANVAYGVAFERVCIVQRQKIAYLGGKGP 219 Query: 252 DGYQVSELRTWLE 264 Y + E+R WLE Sbjct: 220 FCYNLQEVRRWLE 232 >gb|ACX37406.1| iodothyronine deiodinase type I [Phodopus sungorus] Length = 113 Score = 110 bits (275), Expect = 7e-27 Identities = 59/112 (52%), Positives = 73/112 (65%), Gaps = 2/112 (1%) Query: 102 QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +A GG APN V+R G Q I D+ QG+RPLVLNFGSCT P F+ + F+RLV + Sbjct: 3 RAEYGGLAPNCTVVRLSG-QKCNIWDFIQGNRPLVLNFGSCTUPSFLFKFDQFKRLVDDF 61 Query: 162 QRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGC 213 DFLI+YIEEAH +DGW ++ I QHRSLEDR+ AAR+L P C Sbjct: 62 ASTADFLIVYIEEAHATDGWAFKNN-VDIKQHRSLEDRLHAARLLLARNPQC 112 >gb|EKC42322.1| Type I iodothyronine deiodinase [Crassostrea gigas] Length = 120 Score = 109 bits (273), Expect = 2e-26 Identities = 50/119 (42%), Positives = 75/119 (63%), Gaps = 1/119 (0%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M ++ F++LV ++ DFLI+YI EAHPSDGW ++ + I H+ + DR+ A +L Sbjct: 1 MGKLEQFKKLVARFSNVADFLIVYIAEAHPSDGWAFKNN-FDIHTHKGIHDRMKAVDILL 59 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHY 266 + P C +V+D ++N + YGA ERLY++ +G I+Y G RGP GY V E+ WL Y Sbjct: 60 KHQPNCPVVVDDISNDINYKYGAMPERLYIVLNGKIVYLGERGPRGYLVEEVEEWLTKY 118 >gb|ABN54801.1| iodothyronine deiodinase type I [Sander vitreus] Length = 105 Score = 108 bits (271), Expect = 2e-26 Identities = 55/106 (51%), Positives = 75/106 (70%), Gaps = 1/106 (0%) Query: 139 FGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLED 198 FGSCT PPFM ++ F++LV + DFL+IYI EAH +DG T++ + I QHRSLED Sbjct: 1 FGSCTUPPFMYKLEEFKQLVKDFSDVADFLVIYIAEAHATDGLAFTNN-FDINQHRSLED 59 Query: 199 RVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIM 244 R+SAA++L Q P C +V+D M N S+ YGA ERLYV+Q+G ++ Sbjct: 60 RLSAAQILVQKEPQCPVVVDEMNNVSAIKYGALPERLYVLQAGKVV 105 >gb|AAQ05027.1| deiodinase 2 [Scophthalmus maximus] Length = 133 Score = 108 bits (271), Expect = 4e-26 Identities = 54/129 (41%), Positives = 83/129 (64%), Gaps = 6/129 (4%) Query: 143 T*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDS---PYTIPQHRSLEDR 199 T PPF++ + AF++LV + DFL++YI+EAHPSDGWV +++ +H++LE+R Sbjct: 4 TUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVVPPMGPFSFSVRKHQNLEER 63 Query: 200 VSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQV 256 + AAR L + P C LV D M N+++ AYG ER+ ++Q I Y GG+GP Y + Sbjct: 64 LGAARKLTEHFSLPPQCQLVADCMDNNANVAYGVSNERVCIVQQRKIAYLGGKGPFFYNL 123 Query: 257 SELRTWLEH 265 ++R WLE+ Sbjct: 124 KDVRHWLEN 132 >gb|ABD60086.1| type III iodothyronine deiodinase [Rana pipiens] Length = 82 Score = 106 bits (264), Expect = 1e-25 Identities = 50/82 (60%), Positives = 64/82 (78%) Query: 93 HGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMS 152 +GQKLDFFK AH GG APN+EV+ +G + RILD+++G RPLV+NFGSCT PPFMAR+ Sbjct: 1 YGQKLDFFKSAHLGGGAPNTEVVTLEGQRLCRILDFSKGHRPLVVNFGSCTUPPFMARLQ 60 Query: 153 AFQRLVTKYQRDVDFLIIYIEE 174 A+QRL + DFL++YIEE Sbjct: 61 AYQRLAAQRLDFADFLLVYIEE 82 >gb|ABP64746.1| deiodinase type 2 [Carassius auratus] Length = 183 Score = 108 bits (270), Expect = 2e-25 Identities = 54/140 (38%), Positives = 86/140 (61%), Gaps = 14/140 (10%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQ-----------RILDYA 129 R+ T A ++++W LD +KQ G APNS+V++ G + +LD+ Sbjct: 33 RMLTTAGVRSIWDSFLLDAYKQVKLGEAAPNSKVVKVPGINRRWNLSSKTHNECHLLDFE 92 Query: 130 QGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT---TDS 186 +RPLV+NFGS T PPF++++ F+R+V ++ DFL++YI+EAHPSDGW + Sbjct: 93 SPNRPLVVNFGSATUPPFISQLPIFRRMVEEFSDVADFLLVYIDEAHPSDGWAAPPMENF 152 Query: 187 PYTIPQHRSLEDRVSAARVL 206 + + +HR+LE+R+ AAR L Sbjct: 153 SFEVRKHRNLEERMFAARKL 172 >gb|EAX06720.1| deiodinase, iodothyronine, type I [Homo sapiens] gb|EAX06723.1| deiodinase, iodothyronine, type I [Homo sapiens] gb|EAX06725.1| deiodinase, iodothyronine, type I [Homo sapiens] gb|EAX06726.1| deiodinase, iodothyronine, type I [Homo sapiens] Length = 120 Score = 106 bits (265), Expect = 2e-25 Identities = 54/117 (46%), Positives = 73/117 (62%), Gaps = 1/117 (0%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M + F+RL+ + DFL+IYIEEAH SDGW ++ I H++L+DR+ AA +L Sbjct: 1 MFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNN-MDIRNHQNLQDRLQAAHLLL 59 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 +P C +V+DTM N SS Y A ERLY+IQ G I+Y+G GP Y E+R LE Sbjct: 60 ARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVRAVLE 116 >gb|EGW05819.1| Type II iodothyronine deiodinase [Cricetulus griseus] Length = 226 Score = 108 bits (270), Expect = 5e-25 Identities = 69/198 (34%), Positives = 98/198 (49%), Gaps = 44/198 (22%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHE--------GGPAPNSEVIRPDGFQSQRILDYAQGS 132 R+ T L+ VW LD +KQ G APNS V+ ++ Sbjct: 53 RMLTSEGLRCVWKSFLLDAYKQVSSTLLGFVKLGEDAPNSSVVHVSNPEA---------- 102 Query: 133 RPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-VTTDSP--YT 189 AF++LV ++ DFL++YI+EAHPSDGW V DS + Sbjct: 103 --------------------AFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFE 142 Query: 190 IPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQ 246 + +HRS EDR +AA L + P C +V D M N+++ AYG FER+ ++Q I Y Sbjct: 143 VKKHRSQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRQKIAYL 202 Query: 247 GGRGPDGYQVSELRTWLE 264 GG+GP Y + E+R+WLE Sbjct: 203 GGKGPFSYNLQEVRSWLE 220 >emb|CCD22052.1| putative iodothyronine deiodinase type 2.11, partial [Cyprinus carpio] Length = 199 Score = 107 bits (267), Expect = 8e-25 Identities = 53/140 (37%), Positives = 86/140 (61%), Gaps = 14/140 (10%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQ-----------RILDYA 129 R+ T A ++++W+ LD +KQ G APNS+V++ G +LD+ Sbjct: 52 RMLTTAGVRSIWNSFLLDAYKQVKLGEAAPNSKVVKVPGINRHWSVSGKTHNECHLLDFE 111 Query: 130 QGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT---TDS 186 +RPLV+NFGS T PPF++++ F+R+V ++ DFL++YI+EAHPSDGW + Sbjct: 112 SPNRPLVVNFGSATUPPFISQLPIFRRMVEEFSDVADFLLVYIDEAHPSDGWAAPPMENF 171 Query: 187 PYTIPQHRSLEDRVSAARVL 206 + + +HR+LE+R+ AA+ L Sbjct: 172 SFEVRKHRNLEERMFAAQKL 191 >gb|ADI86260.1| iodothyronine deiodinase type 2 [Scarus iseri] Length = 120 Score = 103 bits (258), Expect = 2e-24 Identities = 51/120 (42%), Positives = 79/120 (65%), Gaps = 6/120 (5%) Query: 125 ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT 184 +LD+ RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPSDGWV Sbjct: 1 LLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAP 60 Query: 185 ---DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVI 238 + + +H++LE+R+ AA+ L + P C LV D+M N+++ AYG ER+ ++ Sbjct: 61 PMGSCSFNVRKHQNLEERLGAAQKLIEHFSLPPQCQLVADSMDNNANVAYGVSNERVCIV 120 >gb|EAX06722.1| deiodinase, iodothyronine, type I [Homo sapiens] Length = 136 Score = 104 bits (259), Expect = 2e-24 Identities = 52/113 (46%), Positives = 71/113 (62%), Gaps = 1/113 (0%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M + F+RL+ + DFL+IYIEEAH SDGW ++ I H++L+DR+ AA +L Sbjct: 1 MFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNN-MDIRNHQNLQDRLQAAHLLL 59 Query: 208 QGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELR 260 +P C +V+DTM N SS Y A ERLY+IQ G I+Y+G GP Y E+R Sbjct: 60 ARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEVR 112 >gb|AEK78060.1| iodothyronine deiodinase type 2 [Scarus taeniopterus] Length = 150 Score = 103 bits (258), Expect = 5e-24 Identities = 51/120 (42%), Positives = 79/120 (65%), Gaps = 6/120 (5%) Query: 125 ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT 184 +LD+ RPLV+NFGS T PPF++ + AF++LV + DFL++YI+EAHPSDGWV Sbjct: 31 LLDFESSDRPLVVNFGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAP 90 Query: 185 ---DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSAYGAYFERLYVI 238 + + +H++LE+R+ AA+ L + P C LV D+M N+++ AYG ER+ ++ Sbjct: 91 PMGSCSFNVRKHQNLEERLGAAQKLIEHFSLPPQCQLVADSMDNNANVAYGVSNERVCIV 150 >gb|AEH68216.1| type II iodothyronine deiodinase, partial [Engystomops pustulosus] Length = 108 Score = 102 bits (254), Expect = 6e-24 Identities = 49/107 (45%), Positives = 72/107 (67%), Gaps = 4/107 (3%) Query: 125 ILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT 184 +LD+A RPLV+NFGS T PPF++++ AF +LV ++ DFL++YI+EAHPSDGW Sbjct: 2 LLDFASSERPLVVNFGSATTPPFISQLPAFSKLVEEFSNVADFLLVYIDEAHPSDGWAAP 61 Query: 185 -DSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDTMANSSSSA 227 Y + +HR+LEDR +AA L + P C +V D M N++++A Sbjct: 62 GGGSYEVKKHRNLEDRCAAANKLLENFSLPPQCQVVADCMDNNANAA 108 >gb|AEQ37342.1| deiodinase iodothyronine type 3, partial [Rana sylvatica] Length = 67 Score = 100 bits (248), Expect = 2e-23 Identities = 46/67 (68%), Positives = 56/67 (83%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLV 136 SD NR+CTL SLKAVW+GQKLDFFK AH GG APN+EV+ +G + RILD+++G RPLV Sbjct: 1 SDTNRMCTLESLKAVWYGQKLDFFKSAHLGGGAPNTEVVTLEGQRLCRILDFSKGHRPLV 60 Query: 137 LNFGSCT 143 +NFGSCT Sbjct: 61 VNFGSCT 67 >ref|XP_002585701.1| hypothetical protein BRAFLDRAFT_73773 [Branchiostoma floridae] gb|EEN41712.1| hypothetical protein BRAFLDRAFT_73773 [Branchiostoma floridae] Length = 212 Score = 102 bits (255), Expect = 5e-23 Identities = 46/121 (38%), Positives = 77/121 (63%), Gaps = 1/121 (0%) Query: 146 PFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARV 205 PF A++ +++++ + DF+++Y+ EAHP+DGWV + I QHR LEDR++AA + Sbjct: 91 PFRAKLDMVKQIMSDFAAVADFVVVYVAEAHPTDGWVQRGN-MDIKQHRRLEDRLAAAEM 149 Query: 206 LQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEH 265 L C +++DTM N+++ AY A +RLY++ G +Y+G GP Y E+R WL+ Sbjct: 150 LDLHDIPCPILVDTMDNAAARAYAAMPDRLYIVLDGVCVYKGAPGPIRYHPEEVRDWLQK 209 Query: 266 Y 266 + Sbjct: 210 F 210 >dbj|BAE46994.1| deiodinase iodothyronine type II [Capra hircus] Length = 199 Score = 102 bits (254), Expect = 5e-23 Identities = 58/146 (39%), Positives = 83/146 (56%), Gaps = 20/146 (13%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVI---RPDGFQSQ-------------- 123 R+ T ++ +W LD +KQ G APNS V+ P+G + Sbjct: 42 RMLTSEGMRCIWKSFLLDAYKQVKLGEDAPNSRVVPVSSPEGGDTSGNGAQEKTADGTEC 101 Query: 124 RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW-V 182 +LD+A RPLV+NFGS T PPF ++ AF +LV ++ DFL++YI+EAHPSDGW V Sbjct: 102 HLLDFASPERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAV 161 Query: 183 TTDSP--YTIPQHRSLEDRVSAARVL 206 DS + + +HR+ EDR +AA+ L Sbjct: 162 PGDSSLFFEVKKHRNQEDRCAAAQQL 187 >ref|XP_002603395.1| hypothetical protein BRAFLDRAFT_80387 [Branchiostoma floridae] gb|EEN59406.1| hypothetical protein BRAFLDRAFT_80387 [Branchiostoma floridae] Length = 117 Score = 99.4 bits (246), Expect = 1e-22 Identities = 43/113 (38%), Positives = 76/113 (67%), Gaps = 1/113 (0%) Query: 155 QRLVTKYQRDVDFLIIYIEEAHPSDGW-VTTDSPYTIPQHRSLEDRVSAARVLQQGAPGC 213 +++++ + DF+++Y+ EAHP+DGW ++ I QHRSLE+R++AA +L C Sbjct: 3 KQIMSDFAAVADFVVVYVAEAHPTDGWAISGHLSMDIKQHRSLEERLAAAEMLALHDIPC 62 Query: 214 ALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHY 266 +++DTM N+++ AY A +RLY++ G +Y+G +GP+GY E+R WL+ + Sbjct: 63 PILVDTMDNAAARAYAAIPDRLYIVLDGVCVYKGEQGPNGYHPEEVREWLQKF 115 >gb|AEB16009.1| 5-deiodinase type III [Rana luteiventris] Length = 77 Score = 97.1 bits (240), Expect = 3e-22 Identities = 46/77 (59%), Positives = 59/77 (76%) Query: 93 HGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMS 152 +GQKLDFFK AH GG APN+EV+ +G + RILD+++G RPLV+NFGSCT PPFMAR+ Sbjct: 1 YGQKLDFFKSAHLGGGAPNTEVVTLEGQRLCRILDFSKGHRPLVVNFGSCTUPPFMARLQ 60 Query: 153 AFQRLVTKYQRDVDFLI 169 A+QRL + DFL+ Sbjct: 61 AYQRLAAQRLDFADFLL 77 >ref|XP_002602532.1| hypothetical protein BRAFLDRAFT_93837 [Branchiostoma floridae] gb|EEN58544.1| hypothetical protein BRAFLDRAFT_93837 [Branchiostoma floridae] Length = 136 Score = 95.5 bits (236), Expect = 4e-21 Identities = 50/133 (37%), Positives = 76/133 (57%), Gaps = 14/133 (10%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTD--------------SPYTIPQH 193 MA ++ F +V ++ DFL +YI EAH SDGW + S +H Sbjct: 1 MAHLAKFNDMVAEFADRADFLTVYIAEAHASDGWSFRNNIKIRFFAVVAFLISLGDFRKH 60 Query: 194 RSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDG 253 R+LE+R++AA++L L++DTM + ++ YGA+ ERLY++ G +MY+G GP G Sbjct: 61 RTLEERLTAAKMLADSNLSGPLLVDTMDDVANRKYGAWPERLYILLDGRVMYKGMPGPHG 120 Query: 254 YQVSELRTWLEHY 266 Y V ++R WLE Y Sbjct: 121 YHVHQVRDWLEKY 133 >gb|AAO65269.1| iodothyronine deiodinase type II Deio2 [Danio rerio] Length = 167 Score = 95.9 bits (237), Expect = 6e-21 Identities = 45/113 (39%), Positives = 70/113 (61%), Gaps = 11/113 (9%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ-----------SQRILDYA 129 R+ T A ++++W+ LD +KQ G APNS+V++ G +LD+ Sbjct: 52 RMLTTAGVRSIWNSFLLDAYKQVKLGEAAPNSKVVKVTGINRCWSISGKTHNQCHLLDFE 111 Query: 130 QGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWV 182 RPLV+NFGS T PPF++++ F+R+V ++ DFL++YI+EAHPS+GWV Sbjct: 112 SPDRPLVVNFGSATUPPFISQLPVFRRMVEEFSDVADFLLVYIDEAHPSNGWV 164 >ref|XP_002602534.1| hypothetical protein BRAFLDRAFT_227250 [Branchiostoma floridae] gb|EEN58546.1| hypothetical protein BRAFLDRAFT_227250 [Branchiostoma floridae] Length = 104 Score = 94.0 bits (232), Expect = 7e-21 Identities = 46/101 (45%), Positives = 67/101 (66%), Gaps = 1/101 (0%) Query: 166 DFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSS 225 DFL +YI EAH SDGW ++ I +HR+LE+R+ AA++L L++DTM + ++ Sbjct: 2 DFLTVYIAEAHASDGWSFRNN-IKIRKHRTLEERLIAAKMLADSNLSGPLLVDTMDDVAN 60 Query: 226 SAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLEHY 266 YGA+ ERLY++ G +MY+G GP GY V ++R WLE Y Sbjct: 61 RKYGAWPERLYILLDGRVMYKGMPGPHGYHVHQVRDWLEKY 101 >gb|EDL81667.1| rCG20972 [Rattus norvegicus] Length = 175 Score = 95.9 bits (237), Expect = 7e-21 Identities = 46/105 (43%), Positives = 67/105 (63%), Gaps = 6/105 (5%) Query: 166 DFLIIYIEEAHPSDGWVT---TDSPYTIPQHRSLEDRVSAARVLQQG---APGCALVLDT 219 DFL++YI+EAHPSDGW + + + +HR+ EDR +AA L + P C +V D Sbjct: 65 DFLLVYIDEAHPSDGWAVPGDSSMSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADR 124 Query: 220 MANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 M N+++ AYG FER+ ++Q I Y GG+GP Y + E+R+WLE Sbjct: 125 MDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLE 169 >gb|AAK15277.1| hepatic type I 5'-deiodinase [Bos taurus] Length = 97 Score = 93.6 bits (231), Expect = 8e-21 Identities = 47/97 (48%), Positives = 63/97 (64%), Gaps = 1/97 (1%) Query: 147 FMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVL 206 F+ + F+RL+ + DFLIIYIEEAH SDGW ++ I HR+L+DR+ AA +L Sbjct: 2 FIFKFDQFKRLIEDFGSVADFLIIYIEEAHASDGWAFKNN-VDIKNHRNLQDRLRAAHLL 60 Query: 207 QQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTI 243 +P C +V+DTM N SSS Y A ERLYV+Q G + Sbjct: 61 LDRSPPCPVVVDTMTNQSSSCYAALPERLYVLQEGRV 97 >ref|XP_643546.2| thyroxine 5'-deiodinase [Dictyostelium discoideum AX4] gb|EAL69621.2| thyroxine 5'-deiodinase [Dictyostelium discoideum AX4] Length = 257 Score = 91.3 bits (225), Expect = 1e-18 Identities = 57/157 (36%), Positives = 83/157 (52%), Gaps = 5/157 (3%) Query: 111 NSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLII 170 N EV D F S Q RP+VL GS T PPF +M FQ + ++ VD I+ Sbjct: 81 NQEVSLYDLFNSNNNEKSVQ-DRPMVLICGSFTUPPFRDKMCMFQDIFVDFKEWVDIYIV 139 Query: 171 YIEEAHPSDGWVTTDSPYTI--PQHRSLEDRVSAARVLQQGAPGCAL--VLDTMANSSSS 226 Y++E HP+D W ++ Q +++EDR + L++ AP C + ++D M N+ + Sbjct: 140 YLKEIHPADEWYIGGDEISLCYRQPKTMEDRREIIKDLKEYAPFCTIPFLIDKMDNNFNK 199 Query: 227 AYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWL 263 Y A ERLYV++ Y GG GP G+ ELR +L Sbjct: 200 VYDAVPERLYVLEDKKFKYVGGPGPFGFIPEELREFL 236 >emb|CAG01446.1| unnamed protein product [Tetraodon nigroviridis] Length = 199 Score = 87.8 bits (216), Expect = 8e-18 Identities = 45/86 (52%), Positives = 59/86 (68%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I QHRSLEDR+SAA++L Q P C +V+D M+NS S YGA ERLYV+ Sbjct: 113 DGWAFRNN-IEIKQHRSLEDRLSAAQILVQEEPLCPVVVDDMSNSCSVKYGAMPERLYVL 171 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q+G + Y+G GP GY E+R+ LE Sbjct: 172 QAGKVTYKGAMGPWGYNPQEVRSHLE 197 >ref|XP_001619399.1| hypothetical protein NEMVEDRAFT_v1g224218 [Nematostella vectensis] gb|EDO27299.1| predicted protein [Nematostella vectensis] Length = 158 Score = 84.0 bits (206), Expect = 8e-17 Identities = 40/94 (42%), Positives = 60/94 (63%) Query: 88 LKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQRILDYAQGSRPLVLNFGSCT*PPF 147 L+ VW +D K+ A NS ++ R+LD+A+G RPLV+NFGS T P F Sbjct: 12 LENVWRSILVDMNKKVKLDNKAFNSPLVSLSDEGFCRLLDFAKGDRPLVVNFGSSTCPIF 71 Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGW 181 M +M +++++ +++ DF+I+YIEEAHPSDGW Sbjct: 72 MKKMLEYEKMIVQFKDVADFVIVYIEEAHPSDGW 105 >gb|ABY40367.1| iodothyronine deiodinase type I, partial [Carassius auratus] Length = 85 Score = 80.9 bits (198), Expect = 2e-16 Identities = 38/86 (44%), Positives = 59/86 (68%), Gaps = 1/86 (1%) Query: 135 LVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHR 194 LVL+FGSCT PPF+ ++ F++LV + DFL++Y+ EAH +D W T++ I H+ Sbjct: 1 LVLSFGSCTUPPFLYKLDEFKQLVKDFSDVADFLVVYLAEAHATDAWAFTNN-VDISVHK 59 Query: 195 SLEDRVSAARVLQQGAPGCALVLDTM 220 +LE+R++AAR L + P C +V+D M Sbjct: 60 NLEERLAAARTLVKEDPLCPVVVDEM 85 >emb|CBY15603.1| unnamed protein product [Oikopleura dioica] Length = 122 Score = 80.5 bits (197), Expect = 6e-16 Identities = 44/118 (37%), Positives = 68/118 (57%), Gaps = 3/118 (2%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M + F+++V K+ V FL IY+ EAHP+DGW +S Y +PQ S DR+ +A++L+ Sbjct: 1 MKSILEFEKIVEKFS-SVTFLTIYVREAHPTDGWAINNS-YNLPQAISNSDRIKSAQILK 58 Query: 208 QGAPGCALVL-DTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 A +L D + + + A ERL +I++G + Y GG GP GY + E+ LE Sbjct: 59 AQAANIGTILADAIGDEIEQFFSALPERLAIIKNGKVEYVGGPGPFGYDLDEMVEKLE 116 >emb|CBY11881.1| unnamed protein product [Oikopleura dioica] Length = 122 Score = 80.5 bits (197), Expect = 6e-16 Identities = 44/118 (37%), Positives = 68/118 (57%), Gaps = 3/118 (2%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M + F+++V K+ V FL IY+ EAHP+DGW +S Y +PQ S DR+ +A++L+ Sbjct: 1 MKSILEFEKIVEKFS-SVTFLTIYVREAHPTDGWAINNS-YNLPQAISNSDRIKSAQILK 58 Query: 208 QGAPGCALVL-DTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 A +L D + + + A ERL +I++G + Y GG GP GY + E+ LE Sbjct: 59 AQAANIGTILADAIGDEIEQFFSALPERLAIIKNGKVEYVGGPGPFGYDLDEMVEKLE 116 >emb|CBY15960.1| unnamed protein product [Oikopleura dioica] Length = 122 Score = 80.5 bits (197), Expect = 6e-16 Identities = 44/118 (37%), Positives = 68/118 (57%), Gaps = 3/118 (2%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M + F+++V K+ V FL IY+ EAHP+DGW +S Y +PQ S DR+ +A++L+ Sbjct: 1 MKSILEFEKIVEKFS-SVTFLTIYVREAHPTDGWAINNS-YNLPQAISNSDRIKSAQILK 58 Query: 208 QGAPGCALVL-DTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 A +L D + + + A ERL +I++G + Y GG GP GY + E+ LE Sbjct: 59 AQAANIGTILADAIGDEIEQFFSALPERLAIIKNGKVEYLGGPGPFGYDLDEMVEKLE 116 >ref|NP_001034805.1| type I iodothyronine deiodinase isoform d [Homo sapiens] gb|AAT02484.1| type I iodothyronine deiodinase splice variant e [Homo sapiens] gb|AAH17955.2| Deiodinase, iodothyronine, type I [Homo sapiens] Length = 161 Score = 81.3 bits (199), Expect = 7e-16 Identities = 47/105 (44%), Positives = 61/105 (58%), Gaps = 4/105 (3%) Query: 77 SDDNRLCTLASLKAVWHGQKLDFFK---QAHEGGPAPNSEVIRPDGFQSQRILDYAQGSR 133 S DN + T S + W K+ + + GG APN V+R G Q I ++ QG+R Sbjct: 57 SHDNWIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSG-QRCNIWEFMQGNR 115 Query: 134 PLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPS 178 PLVLNFGSCT P FM + F+RL+ + DFL+IYIEEAH S Sbjct: 116 PLVLNFGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHAS 160 >gb|ABI93490.1| iodothyronine deiodinase type II [Hippoglossus hippoglossus] Length = 92 Score = 79.3 bits (194), Expect = 8e-16 Identities = 42/92 (45%), Positives = 61/92 (66%), Gaps = 6/92 (6%) Query: 139 FGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVT--TDSP-YTIPQHRS 195 FGS T PPF++ + AF++LV + DFL++YI+EAHPSDGWV SP + + +H++ Sbjct: 1 FGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAPPMGSPSFNVRKHQN 60 Query: 196 LEDRVSAARVLQQG---APGCALVLDTMANSS 224 LE+R+ AAR L + P C LV D M N++ Sbjct: 61 LEERLGAARNLTEHFSLPPQCHLVADCMDNNA 92 >emb|CBY40202.1| unnamed protein product [Oikopleura dioica] Length = 117 Score = 79.7 bits (195), Expect = 1e-15 Identities = 42/113 (37%), Positives = 66/113 (58%), Gaps = 3/113 (2%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M + F+++V K+ V FL IY+ EAHP+DGW +S Y +PQ S DR+ +A++L+ Sbjct: 1 MKSILEFEKIVEKFS-SVTFLTIYVREAHPTDGWAINNS-YNLPQAISNSDRIKSAQILK 58 Query: 208 QGAPGCALVL-DTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSEL 259 A +L D + + + A ERL +I++G + Y GG GP GY + E+ Sbjct: 59 AQAANIGTILADAIGDEIEQFFSALPERLAIIKNGKVEYVGGPGPFGYDLDEM 111 >gb|ABK20155.1| iodothyronine deiodinase 2 [Sparus aurata] Length = 92 Score = 79.0 bits (193), Expect = 1e-15 Identities = 40/92 (43%), Positives = 59/92 (64%), Gaps = 6/92 (6%) Query: 139 FGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT---DSPYTIPQHRS 195 FGS T PPF++ + AF++LV + DFL++YI+EAHPSDGWV + + +H++ Sbjct: 1 FGSATUPPFISHLPAFRQLVEDFSDVADFLLVYIDEAHPSDGWVAPPMGSCSFNVRKHQN 60 Query: 196 LEDRVSAARVLQQG---APGCALVLDTMANSS 224 LE+R+ AAR L + P C LV D M N++ Sbjct: 61 LEERLGAARKLIEQFSLPPQCQLVADCMDNNA 92 >emb|CBY06719.1| unnamed protein product [Oikopleura dioica] emb|CBY42217.1| unnamed protein product [Oikopleura dioica] Length = 122 Score = 79.3 bits (194), Expect = 2e-15 Identities = 43/118 (36%), Positives = 67/118 (56%), Gaps = 3/118 (2%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQ 207 M + F+++ K+ V FL IY+ EAHP+DGW +S Y +PQ S +RV +A++L+ Sbjct: 1 MKSIQEFEKIAVKFS-SVKFLTIYVREAHPTDGWAINNS-YNLPQATSNSERVKSAQILK 58 Query: 208 QGAPGCALVL-DTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 A +L D + + + A ERL +I++G + Y GG GP GY + E+ LE Sbjct: 59 AQASNIGTILADPIGDEIEQFFSALPERLAIIKNGKVEYVGGPGPFGYDLDEMVEKLE 116 >gb|EAX06724.1| deiodinase, iodothyronine, type I [Homo sapiens] Length = 91 Score = 76.3 bits (186), Expect = 1e-14 Identities = 39/86 (45%), Positives = 53/86 (61%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I H++L+DR+ AA +L +P C +V+DTM N SS Y A ERLY+I Sbjct: 3 DGWAFKNN-MDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYII 61 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP Y E+R LE Sbjct: 62 QEGRILYKGKSGPWNYNPEEVRAVLE 87 >gb|ABP64745.1| deiodinase type 1 [Carassius auratus] Length = 81 Score = 75.9 bits (185), Expect = 1e-14 Identities = 35/82 (42%), Positives = 55/82 (67%), Gaps = 1/82 (1%) Query: 139 FGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLED 198 FGSCT PPF+ ++ F++LV + DFL++Y+ EAH +D W T++ I H++LE+ Sbjct: 1 FGSCTUPPFLYKLDEFKQLVKDFSDVADFLVVYLAEAHATDAWAFTNN-VDISVHKTLEE 59 Query: 199 RVSAARVLQQGAPGCALVLDTM 220 R++AAR L + P C +V+D M Sbjct: 60 RLAAARTLVKEDPLCPVVVDEM 81 >gb|EHH14806.1| hypothetical protein EGK_00786 [Macaca mulatta] gb|EHH49923.1| hypothetical protein EGM_00664 [Macaca fascicularis] Length = 201 Score = 78.2 bits (191), Expect = 2e-14 Identities = 41/86 (47%), Positives = 53/86 (61%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I HR+L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVI Sbjct: 113 DGWAFKNN-MDIRNHRNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVI 171 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP Y E+R LE Sbjct: 172 QEGRILYKGKSGPWNYNPEEVRAVLE 197 >gb|ABY40368.1| iodothyronine deiodinase type II, partial [Carassius auratus] Length = 107 Score = 75.5 bits (184), Expect = 3e-14 Identities = 36/104 (34%), Positives = 61/104 (58%), Gaps = 11/104 (10%) Query: 81 RLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQ-----------SQRILDYA 129 R+ T A ++++W+ +D +KQ G APNS+V++ G +LD+ Sbjct: 4 RMLTTAGVRSIWNSFLMDAYKQVKLGEAAPNSKVVKVAGINRCWSVSGKTHNECHLLDFE 63 Query: 130 QGSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIE 173 RPLV+NFGS T PPF++++ F+R+V ++ DFL++YI+ Sbjct: 64 SPDRPLVVNFGSATUPPFISQLPVFRRMVEEFSDVADFLLVYID 107 >ref|XP_003815051.1| PREDICTED: type I iodothyronine deiodinase [Pan paniscus] Length = 201 Score = 76.6 bits (187), Expect = 5e-14 Identities = 40/86 (46%), Positives = 53/86 (61%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I H++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVI Sbjct: 113 DGWAFKNN-MDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVI 171 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP Y E+R LE Sbjct: 172 QEGRILYKGKSGPWNYNPEEVRAVLE 197 >ref|XP_003273125.1| PREDICTED: type I iodothyronine deiodinase-like [Nomascus leucogenys] Length = 201 Score = 76.6 bits (187), Expect = 5e-14 Identities = 40/86 (46%), Positives = 53/86 (61%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I H++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVI Sbjct: 113 DGWAFKNN-MDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVI 171 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP Y E+R LE Sbjct: 172 QEGRILYKGKSGPWNYNPEEVRAVLE 197 >ref|XP_002810846.1| PREDICTED: type I iodothyronine deiodinase [Pongo abelii] Length = 201 Score = 76.6 bits (187), Expect = 5e-14 Identities = 40/86 (46%), Positives = 53/86 (61%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I H++L+DR+ AA +L +P C +V+DTM N SS Y A ERLYVI Sbjct: 113 DGWAFKNN-MDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYVI 171 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP Y E+R LE Sbjct: 172 QEGRILYKGKSGPWNYNPEEVRAVLE 197 >ref|NP_001034804.1| type I iodothyronine deiodinase isoform c [Homo sapiens] gb|AAT02483.1| type I iodothyronine deiodinase splice variant d [Homo sapiens] Length = 201 Score = 76.3 bits (186), Expect = 7e-14 Identities = 39/86 (45%), Positives = 53/86 (61%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I H++L+DR+ AA +L +P C +V+DTM N SS Y A ERLY+I Sbjct: 113 DGWAFKNN-MDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYII 171 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP Y E+R LE Sbjct: 172 QEGRILYKGKSGPWNYNPEEVRAVLE 197 >ref|XP_003921585.1| PREDICTED: type I iodothyronine deiodinase [Saimiri boliviensis boliviensis] Length = 201 Score = 75.9 bits (185), Expect = 1e-13 Identities = 39/86 (45%), Positives = 53/86 (61%), Gaps = 1/86 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I H++L+DR+ AA +L +P C +V+DTM N SS Y A ERLY+I Sbjct: 113 DGWAFKNN-VDIRNHQNLQDRLQAAHLLLARSPQCPVVVDTMQNQSSELYAALPERLYII 171 Query: 239 QSGTIMYQGGRGPDGYQVSELRTWLE 264 Q G I+Y+G GP Y E+R LE Sbjct: 172 QEGRILYKGKSGPWNYNPEEVRDVLE 197 >gb|ADI86259.1| iodothyronine deiodinase type I [Scarus iseri] Length = 56 Score = 72.0 bits (175), Expect = 2e-13 Identities = 31/56 (55%), Positives = 42/56 (75%) Query: 131 GSRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDS 186 G+RPLVLNFGSCT PPF+ ++ F++LV + DFL+IYI EAH +DGW T++ Sbjct: 1 GNRPLVLNFGSCTUPPFIFKLEEFKQLVRDFSDVADFLVIYIAEAHSTDGWAFTNN 56 >emb|CBY41529.1| unnamed protein product [Oikopleura dioica] emb|CBY14354.1| unnamed protein product [Oikopleura dioica] Length = 125 Score = 72.4 bits (176), Expect = 5e-13 Identities = 41/124 (33%), Positives = 70/124 (56%), Gaps = 9/124 (7%) Query: 148 MARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTT--DSPYTIPQHRSLEDRVSAARV 205 MA + F+ TK V+FL++Y+ EAHP+DGW+ D P I H++ +R+ AA Sbjct: 1 MASLKKFKE-TTKTFTHVNFLVVYLSEAHPTDGWIIPIEDQP-EISSHQNATERMVAANQ 58 Query: 206 LQQGAPG-----CALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELR 260 L++ ++ DTM N S + A+ ERL V++ +++ GG+GP Y + +L Sbjct: 59 LRERMASDVGLHSKILCDTMDNRISKLFAAHPERLVVLKGEKVIFIGGKGPFDYSIDDLE 118 Query: 261 TWLE 264 ++L+ Sbjct: 119 SFLQ 122 >ref|XP_002611468.1| hypothetical protein BRAFLDRAFT_117208 [Branchiostoma floridae] gb|EEN67478.1| hypothetical protein BRAFLDRAFT_117208 [Branchiostoma floridae] Length = 2419 Score = 77.4 bits (189), Expect = 6e-13 Identities = 37/96 (38%), Positives = 59/96 (61%), Gaps = 1/96 (1%) Query: 146 PFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARV 205 PF A++ +R+++ + DF+++Y+ EAHP+DGWV I QHR LEDR++AA + Sbjct: 148 PFRAKLDMVKRIMSDFAAVADFVVVYVAEAHPTDGWVMRGG-MDIRQHRRLEDRLAAAEM 206 Query: 206 LQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSG 241 L C +++DTM N++ Y A + YVI+ G Sbjct: 207 LALHDIPCPILVDTMDNAAVRTYAAMPDSSYVIEDG 242 Score = 67.0 bits (162), Expect = 1e-09 Identities = 32/84 (38%), Positives = 53/84 (63%), Gaps = 1/84 (1%) Query: 155 QRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCA 214 +R+++ + DF+++Y+ EAHP+DGWV I QHR LEDR++AA +L C Sbjct: 3 KRIMSDFAAVADFVVVYVAEAHPTDGWVMRGG-MDIRQHRRLEDRLAAAEMLALHDIPCP 61 Query: 215 LVLDTMANSSSSAYGAYFERLYVI 238 +++DTM N++ AY A +R ++ Sbjct: 62 ILVDTMDNAAVRAYAAMPDRRQIL 85 >emb|CBY38343.1| unnamed protein product [Oikopleura dioica] Length = 153 Score = 71.2 bits (173), Expect = 2e-12 Identities = 38/99 (38%), Positives = 57/99 (57%), Gaps = 2/99 (2%) Query: 167 FLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVL-DTMANSSS 225 FL IY+ EAH +DGW +S Y +PQ S DR+ +A++L+ A +L D + + Sbjct: 50 FLTIYVREAHRTDGWAINNS-YNLPQAISNSDRIKSAQILKAQAANIGTILADAIGDEIE 108 Query: 226 SAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + A ERL +I++G + Y GG GP GY + E+ LE Sbjct: 109 QFFSALPERLAIIKNGKVEYVGGPGPFGYDLDEMVEKLE 147 >gb|AEQ37341.1| deiodinase iodothyronine type 2, partial [Rana sylvatica] Length = 137 Score = 70.1 bits (170), Expect = 4e-12 Identities = 48/150 (32%), Positives = 69/150 (46%), Gaps = 28/150 (18%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEVPADDPPICVSDD 79 L + P F L L D + + KH L + + +S G+ Sbjct: 5 LQILPGFFSNCLFLALYDSVVLVKHVLLQLNRSK-------SSHGQW------------- 44 Query: 80 NRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIRPDGFQSQ--------RILDYAQG 131 R+ T L+ VW+ LD +KQ GG APNS VI S +LD+A Sbjct: 45 RRMLTPEGLRCVWNSFLLDAYKQVKLGGDAPNSNVIHVTDKNSSSGKPGAPCHLLDFASS 104 Query: 132 SRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 RPLV+NFGS T PPF++++ AF +LV ++ Sbjct: 105 ERPLVVNFGSATUPPFISQLPAFSKLVEEF 134 >gb|AFD01667.1| iodothyronine deiodinase type II, partial [Parus major] Length = 149 Score = 69.3 bits (168), Expect = 1e-11 Identities = 53/161 (32%), Positives = 68/161 (42%), Gaps = 42/161 (26%) Query: 20 LVLFPRFLGTAFMLWLLDFLCIRKH---FLRRRHPDHPEPEVELNSEGEEVPADDPPICV 76 L + P F L L D + + KH FL R E L SEG Sbjct: 11 LQILPVFFSNCLFLALYDSVILLKHMVLFLSRSKSGRGEWRRMLTSEG------------ 58 Query: 77 SDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVIR----PDGFQSQ--------- 123 L+ VW+ LD +KQ GG APNS VI DG Sbjct: 59 -----------LRCVWNSFLLDAYKQVKLGGEAPNSSVIHIAKDSDGSSGNWKNVGGKCG 107 Query: 124 ---RILDYAQGSRPLVLNFGSCT*PPFMARMSAFQRLVTKY 161 +LD+A RPLV+NFGS T PPF +++SAF +LV ++ Sbjct: 108 TKCHLLDFANSERPLVVNFGSATUPPFTSQLSAFSKLVEEF 148 >ref|XP_002740369.1| PREDICTED: deiodinase, iodothyronine, type II-like, partial [Saccoglossus kowalevskii] Length = 247 Score = 69.3 bits (168), Expect = 4e-11 Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 17/128 (13%) Query: 156 RLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTIPQHRSLEDRVSAARVL--------- 206 ++ +Y VDF+ IY+ EAHP DGW D + QH++LEDR+ AAR+L Sbjct: 114 KMFKRYHDRVDFVFIYLLEAHPKDGWSFGDKFSAVKQHQTLEDRIEAARMLVDLNTELLS 173 Query: 207 --QQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMY------QGGRGPDGYQVSE 258 + +++D M NS + +Y A+ +R+ + + T+ + Q + P Sbjct: 174 TDHKAKNKVRVLVDNMENSFAMSYAAWPDRIIIAEGETVSFVSDHVTQVMQNPQNIMTIA 233 Query: 259 LRTWLEHY 266 WLE Y Sbjct: 234 ANAWLEQY 241 >gb|EGV91737.1| Type I iodothyronine deiodinase [Cricetulus griseus] Length = 182 Score = 65.9 bits (159), Expect = 3e-10 Identities = 35/68 (51%), Positives = 43/68 (63%), Gaps = 1/68 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I QHRSL+DR+ AA +L P C +V+DTM N SS Y A ERLYVI Sbjct: 113 DGWAFKNN-VDIRQHRSLQDRLQAAHLLLARNPQCPVVVDTMQNQSSQLYAALPERLYVI 171 Query: 239 QSGTIMYQ 246 Q G I Y+ Sbjct: 172 QEGRICYK 179 >gb|EHB18225.1| Type I iodothyronine deiodinase [Heterocephalus glaber] Length = 188 Score = 65.5 bits (158), Expect = 4e-10 Identities = 33/68 (48%), Positives = 44/68 (64%), Gaps = 1/68 (1%) Query: 179 DGWVTTDSPYTIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVI 238 DGW ++ I QHR+L+DR+ AA +L P C +V+DTM N SS Y A ERLYV+ Sbjct: 113 DGWAFKNN-MDIRQHRNLQDRMRAAHLLLTKTPQCPVVVDTMQNQSSQLYAALPERLYVL 171 Query: 239 QSGTIMYQ 246 Q G I+Y+ Sbjct: 172 QEGRILYK 179 >ref|XP_002112802.1| hypothetical protein TRIADDRAFT_56321 [Trichoplax adhaerens] gb|EDV24912.1| hypothetical protein TRIADDRAFT_56321 [Trichoplax adhaerens] Length = 115 Score = 63.9 bits (154), Expect = 5e-10 Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 5/110 (4%) Query: 160 KYQRDVDFLIIYIEEAHPSDGW----VTTDSPYTIPQHRSLEDRVSAAR-VLQQGAPGCA 214 KY F++IYI+EAH SD W + + + R LE+R+S A+ + + Sbjct: 4 KYADKAQFILIYIKEAHASDEWPLDYLNDSMDVSFKKPRVLEERMSLAKQFIDRFDIKLP 63 Query: 215 LVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 + +D + ++ + Y A ERLYVI+ G I Y+GG GP Y + EL + L+ Sbjct: 64 VYVDDIKDTMAKEYSATPERLYVIRDGKISYKGGPGPMCYDLDELESHLQ 113 >ref|XP_002112745.1| hypothetical protein TRIADDRAFT_56187 [Trichoplax adhaerens] gb|EDV24855.1| hypothetical protein TRIADDRAFT_56187 [Trichoplax adhaerens] Length = 214 Score = 65.5 bits (158), Expect = 6e-10 Identities = 41/112 (36%), Positives = 61/112 (54%), Gaps = 11/112 (9%) Query: 160 KYQRDVDFLIIYIEEAHPSDGW---VTTDSP---YTIPQHRSLEDRVSAAR--VLQQGAP 211 KY +FL +YI EAHPSDGW ++ DS Y P R +EDR+ A+ + P Sbjct: 102 KYGDRANFLTVYIAEAHPSDGWALDLSNDSIGVCYRAP--RKVEDRIYIAKEFIKNYNYP 159 Query: 212 GCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWL 263 L +D++ + + Y + ERLY+I+ G + Y+GG GP Y + E+ L Sbjct: 160 -VPLYVDSITDDTLKTYSSMPERLYIIKDGKVAYKGGPGPYCYSLEEMEEHL 210 >ref|XP_002114085.1| hypothetical protein TRIADDRAFT_58195 [Trichoplax adhaerens] gb|EDV23175.1| hypothetical protein TRIADDRAFT_58195 [Trichoplax adhaerens] Length = 177 Score = 64.7 bits (156), Expect = 7e-10 Identities = 38/105 (36%), Positives = 55/105 (52%), Gaps = 5/105 (4%) Query: 165 VDFLIIYIEEAHPSDGW----VTTDSPYTIPQHRSLEDRVSAAR-VLQQGAPGCALVLDT 219 V F+ +YI EAH SDGW V + + Q + R+ A+ + + +DT Sbjct: 67 VQFITVYILEAHASDGWAMPSVNSGLDTCLLQPKKTGARIQIAKEFVDRFDYKLPFFVDT 126 Query: 220 MANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLE 264 M + AYGA ERLYV++ G I Y+GG GP Y + +L +LE Sbjct: 127 MEGDTMKAYGAQPERLYVVKDGKIAYEGGPGPFCYSIDDLEQFLE 171 >gb|EFA74533.1| thyroxine 5'-deiodinase [Polysphondylium pallidum PN500] Length = 252 Score = 65.5 bits (158), Expect = 1e-09 Identities = 38/135 (28%), Positives = 68/135 (50%), Gaps = 3/135 (2%) Query: 132 SRPLVLNFGSCT*PPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYTI- 190 ++P+VL GS T PF ++ Q + ++ DF I+Y E H +DGW+ + Sbjct: 109 AKPIVLYCGSFTCIPFRNKLQLIQAIANEFAEYCDFYIVYTAEVHTADGWIIGGDEISTA 168 Query: 191 -PQHRSLEDRVSAARVLQQGAP-GCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGG 248 Q +++++R+ LQ+ +P ++D + N+ + Y RL+V+++ Y GG Sbjct: 169 HKQPKTMKERLKIVEALQKFSPVSIPYLVDLIDNNFNEKYDNTPLRLFVLENKKFSYVGG 228 Query: 249 RGPDGYQVSELRTWL 263 GP ELR +L Sbjct: 229 PGPFKSTPEELRDYL 243 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples from WGS projects Posted date: Nov 8, 2012 2:20 PM Number of letters in database: -1,227,654,387 Number of sequences in database: 21,473,622 Lambda K H 0.325 0.140 5.30e-313 Gapped Lambda K H 0.267 0.0410 5.30e-313 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 21473622 Number of Hits to DB: 209401744 Number of extensions: 8544605 Number of successful extensions: 21987 Number of sequences better than 10: 3 Number of HSP's better than 10 without gapping: 0 Number of HSP's gapped: 22147 Number of HSP's successfully gapped: 3 Length of query: 277 Length of database: 7362280201 Length adjustment: 140 Effective length of query: 137 Effective length of database: 4355973121 Effective search space: 596768317577 Effective search space used: 596768317577 T: 11 A: 40 X1: 15 (7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (20.0 bits) S2: 81 (35.8 bits) ka-blk-alpha gapped: 1.9 ka-blk-alpha ungapped: 0.7916 ka-blk-alpha_v gapped: 42.6028 ka-blk-alpha_v ungapped: 4.96466 ka-blk-sigma gapped: 43.6362