BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|299737255|gb|GL376634.1|:subseq(1283980,30000) Pythium
ultimum DAOM BR144 unplaced genomic scaffold scf_1117875582037, whole
genome shotgun sequence:[translate(1)]
         (487 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
           13,389,222 sequences; 290,268,701 total letters

Searching... please wait.. done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_002896377.1| thioredoxin reductase 1 [Phytophthora infest...   801   0.0  
ref|NP_001025933.2| thioredoxin reductase 1 [Gallus gallus]           518   e-145
pdb|1H6V|A Chain A, Mammalian Thioredoxin Reductase >gi|15826813...   513   e-143
pdb|3EAN|A Chain A, Crystal Structure Of Recombinant Rat Selenop...   512   e-143
gb|EDM17072.1| thioredoxin reductase 1, isoform CRA_b [Rattus no...   511   e-143
gb|EDM17071.1| thioredoxin reductase 1, isoform CRA_a [Rattus no...   511   e-143
gb|AAH85726.1| Txnrd1 protein [Rattus norvegicus]                     511   e-143
ref|NP_777050.1| thioredoxin reductase 1, cytoplasmic [Bos tauru...   511   e-143
ref|NP_113802.2| thioredoxin reductase 1, cytoplasmic [Rattus no...   511   e-143
dbj|BAE26918.1| unnamed protein product [Mus musculus]                511   e-143
ref|XP_002798903.1| PREDICTED: thioredoxin reductase 1, cytoplas...   511   e-143
ref|XP_002181543.1| predicted protein [Phaeodactylum tricornutum...   511   e-143
ref|NP_001116141.1| thioredoxin reductase 1, cytoplasmic [Pan tr...   511   e-143
gb|EDL21377.1| thioredoxin reductase 1, isoform CRA_b [Mus muscu...   511   e-143
gb|AAH37643.1| Thioredoxin reductase 1 [Mus musculus] >gi|742122...   511   e-143
ref|NP_001035988.1| thioredoxin reductase 1, cytoplasmic isoform...   511   e-143
ref|NP_056577.2| thioredoxin reductase 1, cytoplasmic isoform 2 ...   511   e-143
sp|Q5NVA2|TRXR1_PONAB RecName: Full=Thioredoxin reductase 1, cyt...   511   e-142
ref|XP_001744219.1| hypothetical protein [Monosiga brevicollis M...   511   e-142
pdb|2ZZ0|A Chain A, Crystal Structure Of Human Thioredoxin Reduc...   510   e-142
dbj|BAH11961.1| unnamed protein product [Homo sapiens]                510   e-142
ref|XP_002594765.1| hypothetical protein BRAFLDRAFT_122807 [Bran...   510   e-142
pdb|2J3N|A Chain A, X-Ray Structure Of Human Thioredoxin Reducta...   510   e-142
ref|NP_001087240.1| thioredoxin reductase 1, cytoplasmic isoform...   510   e-142
ref|NP_003321.3| thioredoxin reductase 1, cytoplasmic isoform 1 ...   510   e-142
gb|EAW97743.1| thioredoxin reductase 1 [Homo sapiens] >gi|119618...   510   e-142
gb|EAW97745.1| thioredoxin reductase 1 [Homo sapiens] >gi|221044...   510   e-142
pdb|2CFY|A Chain A, Crystal Structure Of Human Thioredoxin Reduc...   510   e-142
emb|CAA04503.1| thioredoxin reductase [Homo sapiens] >gi|5469614...   510   e-142
ref|NP_877393.1| thioredoxin reductase 1, cytoplasmic isoform 2 ...   510   e-142
dbj|BAA13674.1| KM-102-derived reductase-like factor [Homo sapiens]   510   e-142
ref|NP_001131081.1| thioredoxin reductase 1 [Equus caballus]          510   e-142
ref|XP_002752975.1| PREDICTED: thioredoxin reductase 1, cytoplas...   509   e-142
ref|XP_002752974.1| PREDICTED: thioredoxin reductase 1, cytoplas...   509   e-142
emb|CAG38744.1| TXNRD1 [Homo sapiens]                                 509   e-142
ref|XP_003126688.1| PREDICTED: thioredoxin reductase 1, cytoplas...   508   e-142
ref|XP_001507796.1| PREDICTED: similar to thioredoxin reductase ...   508   e-142
ref|NP_898895.2| thioredoxin reductase 3 [Danio rerio]                508   e-142
gb|AAL15432.1| thioredoxin reductase 1 [Homo sapiens]                 508   e-142
gb|AAB35418.1| thioredoxin reductase [Homo sapiens] >gi|1237038|...   508   e-142
gb|AAC69621.1| thioredoxin reductase GRIM-12 [Homo sapiens]           508   e-142
gb|AAH54599.1| Thioredoxin reductase 1 [Danio rerio] >gi|1828921...   508   e-142
gb|AAI67349.1| MGC147163 protein [Xenopus (Silurana) tropicalis]      508   e-141
gb|AAI54785.1| Thioredoxin reductase 1 [Danio rerio]                  508   e-141
gb|AAC35244.2| thioredoxin reductase [Rattus norvegicus]              508   e-141
ref|NP_001127133.1| thioredoxin reductase 1, cytoplasmic [Pongo ...   508   e-141
ref|NP_999319.2| thioredoxin reductase 1, cytoplasmic [Sus scrofa]    507   e-141
ref|NP_001087786.1| thioredoxin reductase 1 [Xenopus laevis] >gi...   506   e-141
gb|AAF15900.1|AF208018_1 thioredoxin reductase [Homo sapiens]         506   e-141
ref|NP_001087660.1| thioredoxin reductase 3 [Xenopus laevis] >gi...   505   e-141
ref|XP_001365687.1| PREDICTED: similar to Thioredoxin reductase ...   504   e-141
emb|CBN80599.1| Thioredoxin reductase 3 [Dicentrarchus labrax]        503   e-140
gb|AAF32362.1|AF220760_1 thioredoxin reductase 1 [Rattus norvegi...   503   e-140
sp|Q9MYY8|TRXR1_PIG RecName: Full=Thioredoxin reductase 1, cytop...   503   e-140
gb|AAD43039.1|AF108213_1 NADPH-dependent thioredoxin reductase [...   503   e-140
ref|NP_001116145.1| thioredoxin reductase 1, cytoplasmic [Canis ...   503   e-140
sp|O89049|TRXR1_RAT RecName: Full=Thioredoxin reductase 1, cytop...   502   e-140
emb|CAH92925.2| thioredoxin reductase [Pongo abelii]                  502   e-140
ref|XP_002938124.1| PREDICTED: thioredoxin reductase 1, cytoplas...   499   e-139
ref|NP_001116249.1| thioredoxin reductase 3 [Gallus gallus]           498   e-139
gb|AAN06824.1| thioredoxin reductase [Sus scrofa]                     498   e-139
gb|EFW43678.1| thioredoxin reductase 3 [Capsaspora owczarzaki AT...   497   e-138
ref|XP_002915522.1| PREDICTED: thioredoxin reductase 1, cytoplas...   497   e-138
ref|XP_002288115.1| thioredoxin reductase [Thalassiosira pseudon...   497   e-138
dbj|BAC87474.1| unnamed protein product [Homo sapiens]                495   e-138
ref|NP_001116163.1| thioredoxin reductase 2, mitochondrial [Gall...   494   e-137
ref|XP_516719.2| PREDICTED: thioredoxin reductase 3 [Pan troglod...   494   e-137
gb|AAH30028.1| TXNRD3 protein [Homo sapiens]                          493   e-137
emb|CBK24910.2| unnamed protein product [Blastocystis hominis] >...   493   e-137
sp|Q86VQ6|TRXR3_HUMAN RecName: Full=Thioredoxin reductase 3; Alt...   492   e-137
ref|NP_443115.1| thioredoxin reductase 3 isoform 1 [Homo sapiens]     492   e-137
gb|AAH50032.1| TXNRD3 protein [Homo sapiens]                          492   e-137
gb|AAD51325.1|AF171055_1 thioredoxin reductase TR2 [Homo sapiens]     492   e-137
ref|NP_001080052.1| thioredoxin reductase 2 [Xenopus laevis]          492   e-137
ref|XP_001377333.1| PREDICTED: similar to TXNRD3 protein [Monode...   492   e-137
gb|AAH56136.1| Txnrd2 protein [Xenopus laevis]                        492   e-137
ref|NP_001120487.1| thioredoxin reductase 2 [Xenopus (Silurana) ...   491   e-137
emb|CBY19735.1| unnamed protein product [Oikopleura dioica]           491   e-136
ref|NP_001116250.1| thioredoxin reductase 3 [Canis lupus familia...   491   e-136
ref|XP_001492801.1| PREDICTED: similar to thioredoxin reductase ...   490   e-136
gb|AAD39929.1|AF133519_1 thioredoxin reductase 3 [Homo sapiens]       490   e-136
ref|XP_002923145.1| PREDICTED: thioredoxin reductase 3-like [Ail...   489   e-136
gb|EFB23450.1| hypothetical protein PANDA_012236 [Ailuropoda mel...   489   e-136
ref|XP_002108982.1| hypothetical protein TRIADDRAFT_19325 [Trich...   487   e-135
ref|NP_001171529.1| thioredoxin reductase 3 isoform 1 [Mus muscu...   486   e-135
sp|Q99MD6|TRXR3_MOUSE RecName: Full=Thioredoxin reductase 3; Alt...   486   e-135
ref|XP_001630291.1| predicted protein [Nematostella vectensis] >...   486   e-135
ref|XP_975772.1| PREDICTED: similar to thioredoxin reductase iso...   486   e-135
ref|NP_694802.2| thioredoxin reductase 3 isoform 2 [Mus musculus...   486   e-135
gb|AAD25167.1|AF044212_1 thioredoxin reductase [Homo sapiens]         486   e-135
ref|NP_006431.2| thioredoxin reductase 2, mitochondrial precurso...   486   e-135
dbj|BAB28419.1| unnamed protein product [Mus musculus] >gi|26348...   486   e-135
gb|AAD19597.1| thioredoxin reductase [Homo sapiens]                   486   e-135
ref|XP_002920642.1| PREDICTED: thioredoxin reductase 2, mitochon...   486   e-135
gb|AAI17355.1| TXNRD2 protein [Homo sapiens] >gi|313883426|gb|AD...   485   e-135
dbj|BAA77601.2| thioredoxin reductase II alpha [Homo sapiens]         485   e-135
dbj|BAA77602.2| thioredoxin reductase II beta [Homo sapiens]          485   e-135
gb|EFN85970.1| Thioredoxin reductase 1, mitochondrial [Harpegnat...   485   e-135
dbj|BAD92961.1| thioredoxin reductase 2 isoform 1 precursor vari...   485   e-135
gb|AAG47635.1|AF201385_1 mitochondrial thioredoxin reductase [Ho...   485   e-135
ref|XP_002830900.1| PREDICTED: thioredoxin reductase 2, mitochon...   484   e-134
ref|NP_001171641.1| thioredoxin reductase 3 isoform 1 [Rattus no...   484   e-134
ref|NP_001100079.2| thioredoxin reductase 3 isoform 2 [Rattus no...   484   e-134
ref|NP_001152971.1| thioredoxin reductase 2 precursor [Macaca mu...   484   e-134
gb|AAH07489.3| TXNRD2 protein [Homo sapiens]                          484   e-134
emb|CAF96941.1| unnamed protein product [Tetraodon nigroviridis]      484   e-134
gb|EFX87625.1| hypothetical protein DAPPUDRAFT_306444 [Daphnia p...   483   e-134
ref|XP_850181.1| PREDICTED: similar to thioredoxin reductase 2 i...   483   e-134
ref|XP_002713123.1| PREDICTED: Thioredoxin reductase 3-like, par...   483   e-134
pdb|2X8C|A Chain A, Thioredoxin Glutathione Reductase From Schis...   482   e-134
pdb|3H4K|A Chain A, Crystal Structure Of The Wild Type Thioredox...   482   e-134
pdb|2V6O|A Chain A, Structure Of Schistosoma Mansoni Thioredoxin...   482   e-134
gb|AAW25951.1| SJCHGC06622 protein [Schistosoma japonicum]            482   e-134
gb|AAK85233.1|AF395822_1 thioredoxin glutathione reductase [Schi...   482   e-134
ref|NP_001162173.1| thioredoxin reductase 2, mitochondrial [Sus ...   480   e-133
gb|EFN67124.1| Thioredoxin reductase 1, mitochondrial [Camponotu...   479   e-133
ref|XP_002596165.1| hypothetical protein BRAFLDRAFT_203192 [Bran...   479   e-133
pdb|3DGZ|A Chain A, Crystal Structure Of Mouse Mitochondrial Thi...   479   e-133
gb|EDK97524.1| thioredoxin reductase 2, isoform CRA_a [Mus muscu...   479   e-133
sp|Q9JLT4|TRXR2_MOUSE RecName: Full=Thioredoxin reductase 2, mit...   479   e-133
gb|AAF03359.1|AF136399_1 thioredoxin reductase [Mus musculus]         479   e-133
ref|NP_038739.2| thioredoxin reductase 2, mitochondrial precurso...   479   e-133
pdb|1ZDL|A Chain A, Crystal Structure Of Mouse Thioredoxin Reduc...   479   e-133
dbj|BAA86986.2| thioredoxin reductase 2 [Mus musculus]                479   e-133
ref|NP_777051.1| thioredoxin reductase 2, mitochondrial precurso...   479   e-133
gb|EFZ12491.1| hypothetical protein SINV_11881 [Solenopsis invicta]   479   e-133
gb|ACH86016.1| thioredoxin glutathione reductase [Schistosoma ja...   479   e-133
ref|XP_002948663.1| NADPH-dependent thioredoxin reductase 1 [Vol...   478   e-133
sp|B9A1H3|TRXR1_EMIHU RecName: Full=Thioredoxin reductase SEP1; ...   478   e-133
ref|XP_002154390.1| PREDICTED: similar to MGC81848 protein [Hydr...   478   e-133
ref|XP_002071893.1| GK24920 [Drosophila willistoni] >gi|19416797...   478   e-133
ref|XP_001662666.1| thioredoxin reductase [Aedes aegypti] >gi|10...   478   e-132
ref|XP_001662665.1| thioredoxin reductase [Aedes aegypti] >gi|10...   478   e-132
ref|XP_001488273.1| PREDICTED: similar to TXNRD2 protein [Equus ...   476   e-132
gb|EDL77943.1| thioredoxin reductase 2, isoform CRA_a [Rattus no...   476   e-132
ref|NP_072106.1| thioredoxin reductase 2, mitochondrial precurso...   476   e-132
ref|XP_002734086.1| PREDICTED: thioredoxin reductase 1-like [Sac...   475   e-132
ref|XP_001966148.1| GF19373 [Drosophila ananassae] >gi|190623033...   474   e-131
ref|XP_001696072.1| NADPH-dependent thioredoxin reductase 1 [Chl...   474   e-131
ref|XP_001455671.1| hypothetical protein [Paramecium tetraurelia...   474   e-131
ref|XP_001354460.2| GA15270 [Drosophila pseudoobscura pseudoobsc...   474   e-131
ref|XP_001425944.1| hypothetical protein [Paramecium tetraurelia...   474   e-131
gb|AAC69637.1| glutathione reductase family member [Musca domest...   473   e-131
ref|NP_001177260.1| thioredoxin reductase 3 [Ciona intestinalis]      473   e-131
gb|EFB13457.1| hypothetical protein PANDA_003518 [Ailuropoda mel...   473   e-131
ref|XP_001847793.1| thioredoxin reductase 1, mitochondrial [Cule...   473   e-131
ref|XP_002101164.1| GE15773 [Drosophila yakuba] >gi|194188688|gb...   472   e-131
ref|XP_001977919.1| GG19308 [Drosophila erecta] >gi|190649568|gb...   472   e-131
gb|AAG25640.1|AF301145_1 thioredoxin reductase-1 splice variant ...   471   e-130
ref|NP_727251.1| thioredoxin reductase-1, isoform B [Drosophila ...   471   e-130
ref|NP_511082.2| thioredoxin reductase-1, isoform A [Drosophila ...   471   e-130
ref|NP_727252.1| thioredoxin reductase-1, isoform C [Drosophila ...   471   e-130
gb|ADH94550.1| thioredoxin reductase 1 [Apis cerana cerana] >gi|...   470   e-130
ref|XP_002722800.1| PREDICTED: thioredoxin reductase 2-like [Ory...   470   e-130
ref|XP_001991610.1| GH12753 [Drosophila grimshawi] >gi|193901368...   470   e-130
pdb|3DH9|A Chain A, Crystal Structure Of Drosophila Thioredoxin ...   469   e-130
pdb|3DGH|A Chain A, Crystal Structure Of Drosophila Thioredoxin ...   469   e-130
ref|XP_001603220.1| PREDICTED: similar to thioredoxin reductase ...   469   e-130
pdb|2NVK|X Chain X, Crystal Structure Of Thioredoxin Reductase F...   469   e-130
ref|NP_001171496.1| thioredoxin reductase 1 isoform 1 [Apis mell...   469   e-130
gb|AAP93583.1| thioredoxin reductase [Apis mellifera ligustica]       469   e-130
ref|NP_001171497.1| thioredoxin reductase 1 isoform 2 [Apis mell...   469   e-130
ref|XP_002056889.1| GJ16646 [Drosophila virilis] >gi|194146656|g...   469   e-130
gb|EFV61343.1| thioredoxin reductase 1, cytoplasmic [Trichinella...   468   e-129
ref|XP_001014761.2| thioredoxin and glutathione reductase family...   468   e-129
gb|EFR25272.1| hypothetical protein AND_09546 [Anopheles darlingi]    467   e-129
ref|XP_797733.2| PREDICTED: hypothetical protein [Strongylocentr...   467   e-129
ref|XP_002697197.1| PREDICTED: thioredoxin reductase 3 [Bos taur...   467   e-129
ref|NP_001179038.1| thioredoxin reductase 3 [Bos taurus]              467   e-129
ref|XP_002010389.1| GI15898 [Drosophila mojavensis] >gi|19390883...   467   e-129
gb|ADD18525.1| thioredoxin reductase-1 [Glossina morsitans morsi...   466   e-129
gb|AAN32903.1| thioredoxin reductase TR1 [Chlamydomonas reinhard...   465   e-129
ref|XP_001958552.1| GF23459 [Drosophila ananassae] >gi|190625834...   463   e-128
ref|XP_002047939.1| GJ11643 [Drosophila virilis] >gi|194155097|g...   462   e-128
dbj|BAH11490.1| unnamed protein product [Homo sapiens]                461   e-127
gb|EGB07743.1| selenoprotein [Aureococcus anophagefferens]            461   e-127
emb|CBN76987.1| Thioredoxin reductase [Ectocarpus siliculosus]        461   e-127
ref|XP_002009206.1| GI11388 [Drosophila mojavensis] >gi|19392081...   460   e-127
ref|XP_001942650.1| PREDICTED: similar to thioredoxin reductase ...   460   e-127
ref|XP_001984837.1| GH16699 [Drosophila grimshawi] >gi|193898319...   459   e-127
ref|XP_001973742.1| GG16263 [Drosophila erecta] >gi|190655525|gb...   459   e-127
gb|EEZ99907.1| hypothetical protein TcasGA2_TC002698 [Tribolium ...   459   e-127
dbj|BAH12374.1| unnamed protein product [Homo sapiens]                459   e-127
ref|XP_514983.2| PREDICTED: thioredoxin reductase 2 isoform 4 [P...   459   e-127
ref|XP_001166615.1| PREDICTED: similar to mitochondrial thioredo...   459   e-127
ref|XP_003074475.1| thioredoxin reductase TR1 (ISS) [Ostreococcu...   458   e-127
gb|AAN63052.1| thioredoxin glutathione reductase [Echinococcus g...   458   e-127
gb|AAN63051.1| thioredoxin glutathione reductase [Echinococcus g...   458   e-127
emb|CAM96615.1| thioredoxin-glutathione reductase [Fasciola hepa...   457   e-126
ref|XP_002028236.1| GL23230 [Drosophila persimilis] >gi|19411735...   456   e-126
ref|XP_002115731.1| hypothetical protein TRIADDRAFT_50766 [Trich...   456   e-126
ref|XP_001415584.1| thioredoxin reductase, putative selenoenzyme...   456   e-126
ref|XP_001352389.2| GA10979 [Drosophila pseudoobscura pseudoobsc...   455   e-126
ref|XP_002040924.1| GM22453 [Drosophila sechellia] >gi|194122434...   455   e-126
gb|ADY41259.1| Thioredoxin reductase 1 [Ascaris suum]                 455   e-126
ref|XP_002086704.1| GE23284 [Drosophila yakuba] >gi|194186494|gb...   454   e-125
dbj|BAE72986.1| hypothetical protein [Macaca fascicularis]            454   e-125
emb|CBJ26963.1| Electron donor (NADH / NADPH)-dependent reductas...   453   e-125
ref|XP_003056182.1| thioredoxin-disufide reductase [Micromonas p...   453   e-125
gb|EAX03014.1| hCG17888, isoform CRA_b [Homo sapiens]                 453   e-125
gb|EAX03013.1| hCG17888, isoform CRA_a [Homo sapiens]                 453   e-125
ref|NP_524216.1| thioredoxin reductase 2 [Drosophila melanogaste...   452   e-125
ref|XP_310514.3| thioredoxin reductase (AGAP000565-PB) [Anophele...   452   e-125
emb|CAD30858.1| thioredoxin reductase [Anopheles gambiae]             452   e-125
ref|XP_001237264.1| AGAP000565-PA [Anopheles gambiae str. PEST] ...   452   e-125
ref|XP_002674924.1| thioredoxin reductase [Naegleria gruberi] >g...   451   e-124
gb|EFB29376.1| hypothetical protein PANDA_009396 [Ailuropoda mel...   449   e-124
ref|XP_002423998.1| thioredoxin reductase, putative [Pediculus h...   449   e-124
ref|XP_002773322.1| thioredoxin reductase 1, cytoplasmic, putati...   448   e-123
gb|DAA20379.1| thioredoxin reductase 2, mitochondrial precursor ...   447   e-123
gb|EAW79356.1| hCG40656, isoform CRA_b [Homo sapiens]                 445   e-123
gb|ACL81231.1| thioredoxin reductase 2 [Moneuplotes crassus]          442   e-122
dbj|BAE28994.1| unnamed protein product [Mus musculus]                441   e-122
gb|ACL81230.1| thioredoxin reductase 1 [Moneuplotes crassus]          441   e-121
ref|XP_002428198.1| thioredoxin reductase, putative [Pediculus h...   440   e-121
ref|XP_003093270.1| CRE-TRXR-1 protein [Caenorhabditis remanei] ...   439   e-121
ref|XP_002633065.1| C. briggsae CBR-TRXR-1 protein [Caenorhabdit...   439   e-121
ref|XP_001898729.1| Thioredoxin reductase [Brugia malayi] >gi|15...   438   e-121
ref|XP_666572.1| thioredoxin reductase [Cryptosporidium hominis ...   437   e-120
dbj|BAJ77264.1| cgd2_4320 [Cryptosporidium parvum] >gi|323510267...   437   e-120
gb|AAN05789.1| putative thioredoxin reductase [Cryptosporidium p...   437   e-120
ref|XP_626611.1| thioredoxin reductase 1 [Cryptosporidium parvum...   437   e-120
ref|XP_969619.1| PREDICTED: similar to thioredoxin reductase [Tr...   434   e-119
gb|ACV31866.1| thioredoxin reductase [Cryptosporidium parvum]         434   e-119
gb|AAD46625.1| thioredoxin reductase homolog [Caenorhabditis ele...   433   e-119
ref|NP_501085.2| ThioRedoXin Reductase family member (trxr-1) [C...   433   e-119
gb|ADL62852.1| thioredoxin reductase 1 [Haemonchus contortus]         432   e-119
ref|NP_001166984.1| thioredoxin reductase 3 isoform 2 [Homo sapi...   432   e-119
ref|XP_001614770.1| thioredoxin reductase 2 [Plasmodium vivax Sa...   432   e-119
ref|XP_002085912.1| GD15034 [Drosophila simulans] >gi|194197921|...   430   e-118
ref|XP_002258509.1| thioredoxin reductase 2 [Plasmodium knowlesi...   429   e-118
ref|XP_001427531.1| hypothetical protein [Paramecium tetraurelia...   429   e-118
gb|EAX03015.1| hCG17888, isoform CRA_c [Homo sapiens]                 429   e-118
ref|XP_003137903.1| thioredoxin reductase [Loa loa] >gi|30776693...   428   e-117
ref|XP_001459173.1| hypothetical protein [Paramecium tetraurelia...   427   e-117
ref|XP_745009.1| Thioredoxin reductase [Plasmodium chabaudi chab...   427   e-117
gb|EDK97526.1| thioredoxin reductase 2, isoform CRA_c [Mus muscu...   426   e-117
ref|XP_001166546.1| PREDICTED: thioredoxin reductase 2 isoform 2...   426   e-117
gb|AAQ03230.1|AF412308_1 mitochondrial thioredoxin reductase 2 [...   426   e-117
dbj|BAG53517.1| unnamed protein product [Homo sapiens]                424   e-116
emb|CAG09709.1| unnamed protein product [Tetraodon nigroviridis]      423   e-116
emb|CBZ54959.1| MGC84926 protein, related [Neospora caninum Live...   422   e-116
ref|XP_730274.1| thioredoxin reductase [Plasmodium yoelii yoelii...   422   e-116
ref|XP_002808951.1| thioredoxin reductase [Plasmodium falciparum...   421   e-115
sp|Q25861|TRXR_PLAF5 RecName: Full=Thioredoxin reductase; Short=...   421   e-115
ref|XP_679935.1| Thioredoxin reductase [Plasmodium berghei strai...   418   e-114
gb|EEE25525.1| thioredoxin reductase, putative [Toxoplasma gondi...   417   e-114
ref|XP_001452173.1| hypothetical protein [Paramecium tetraurelia...   416   e-114
ref|XP_001031449.2| Pyridine nucleotide-disulphide oxidoreductas...   416   e-114
ref|XP_002364220.1| thioredoxin reductase, putative [Toxoplasma ...   415   e-114
ref|XP_001519650.1| PREDICTED: hypothetical protein, partial [Or...   407   e-111
ref|XP_002404402.1| thioredoxin reductase, putative [Ixodes scap...   406   e-111
ref|XP_002142781.1| thioredoxin reductase [Cryptosporidium muris...   406   e-111
ref|XP_002680287.1| predicted protein [Naegleria gruberi] >gi|28...   405   e-111
ref|XP_001031841.1| thioredoxin and glutathione reductase family...   403   e-110
emb|CAA58583.1| thioredoxin reductase [Plasmodium falciparum]         401   e-109
ref|XP_001011080.1| thioredoxin and glutathione reductase family...   400   e-109
ref|XP_001460198.1| hypothetical protein [Paramecium tetraurelia...   399   e-109
ref|XP_002062260.1| GK16764 [Drosophila willistoni] >gi|19415834...   397   e-108
emb|CBK22083.2| unnamed protein product [Blastocystis hominis]        396   e-108
ref|XP_001453518.1| hypothetical protein [Paramecium tetraurelia...   395   e-108
gb|ADY44068.1| Glutathione reductase 2 [Ascaris suum]                 394   e-107
ref|XP_001027232.1| thioredoxin and glutathione reductase family...   394   e-107
ref|XP_001638616.1| predicted protein [Nematostella vectensis] >...   390   e-106
gb|EAX03016.1| hCG17888, isoform CRA_d [Homo sapiens]                 386   e-105
gb|AAF21432.1|AF166127_1 selenoprotein Zf2 [Homo sapiens]             386   e-105
ref|XP_001432974.1| hypothetical protein [Paramecium tetraurelia...   385   e-105
dbj|BAG61457.1| unnamed protein product [Homo sapiens]                385   e-104
gb|ADL62853.1| thioredoxin reductase 2 [Haemonchus contortus]         383   e-104
gb|EDL91334.1| thioredoxin reductase 3 (predicted) [Rattus norve...   382   e-104
ref|XP_003098207.1| CRE-TRXR-2 protein [Caenorhabditis remanei] ...   377   e-102
ref|XP_001608869.1| thiodoxin reductase [Babesia bovis T2Bo] >gi...   377   e-102
ref|NP_498971.1| ThioRedoXin Reductase family member (trxr-2) [C...   370   e-100
ref|XP_002642468.1| C. briggsae CBR-TRXR-2 protein [Caenorhabdit...   369   e-100
ref|XP_002765367.1| Thioredoxin reductase, putative [Perkinsus m...   363   4e-98
ref|XP_954814.1| thioredoxin reductase [Theileria annulata strai...   362   9e-98
ref|XP_763128.1| thioredoxin reductase [Theileria parva strain M...   359   5e-97
gb|AAB48441.1| glutathione reductase [Drosophila melanogaster]        338   1e-90
ref|XP_001032862.1| Pyridine nucleotide-disulphide oxidoreductas...   337   3e-90
ref|XP_001362937.1| PREDICTED: similar to extracellular reelin [...   336   5e-90
gb|AAK93067.1| GM14215p [Drosophila melanogaster]                     333   3e-89
gb|AAL27545.1| thioredoxin reductase 1 [Mus musculus]                 322   6e-86
ref|XP_002743594.1| PREDICTED: hypothetical protein LOC100413738...   318   2e-84
gb|AAT85828.1| putative thioredoxin reductase [Glossina morsitan...   316   4e-84
ref|XP_001440369.1| hypothetical protein [Paramecium tetraurelia...   315   1e-83
gb|ADY41842.1| Thioredoxin reductase 1 [Ascaris suum]                 310   2e-82
ref|NP_001072534.1| thioredoxin reductase 3 [Xenopus (Silurana) ...   308   2e-81
gb|EAW79355.1| hCG40656, isoform CRA_a [Homo sapiens]                 305   1e-80
dbj|BAB27905.1| unnamed protein product [Mus musculus]                303   4e-80
ref|XP_001338711.3| PREDICTED: im:7135991 [Danio rerio]               295   8e-78
gb|AAH13688.1| Txnrd2 protein [Mus musculus]                          290   4e-76
ref|ZP_01629769.1| glutathione reductase [Nodularia spumigena CC...   288   1e-75
emb|CAF29507.1| hypothetical protein [Homo sapiens] >gi|51476567...   287   3e-75
emb|CAH65367.1| hypothetical protein RCJMB04_23a5 [Gallus gallus]     286   4e-75
gb|AAH99923.1| TXNRD2 protein [Homo sapiens]                          286   5e-75
ref|XP_001166507.1| PREDICTED: hypothetical protein isoform 1 [P...   286   5e-75
ref|YP_001652255.1| glutathione reductase [Actinobacillus pleuro...   286   6e-75
ref|ZP_00135555.2| COG1249: Pyruvate/2-oxoglutarate dehydrogenas...   285   1e-74
ref|ZP_07528241.1| Glutathione reductase [Actinobacillus pleurop...   284   2e-74
ref|ZP_08066809.1| glutathione-disulfide reductase [Actinobacill...   284   2e-74
gb|ABB88584.1| glutathione reductase [Ulva fasciata]                  284   2e-74
ref|ZP_07888841.1| glutathione-disulfide reductase [Aggregatibac...   282   7e-74
ref|ZP_07339108.1| glutathione reductase [Actinobacillus pleurop...   282   7e-74
ref|YP_390410.1| glutathione reductase [Thiomicrospira crunogena...   282   7e-74
emb|CBW15027.1| glutathione oxidoreductase [Haemophilus parainfl...   282   9e-74
ref|ZP_05037269.1| FAD dependent oxidoreductase, putative [Synec...   281   1e-73
gb|AAO65266.1| thioredoxin reductase TrxR1 [Danio rerio]              281   1e-73
ref|YP_001352656.1| glutathione reductase [Janthinobacterium sp....   281   2e-73
ref|ZP_02156112.1| glutathione reductase [Shewanella benthica KT...   281   2e-73
ref|ZP_06126460.2| glutathione-disulfide reductase [Providencia ...   280   3e-73
ref|ZP_05025849.1| glutathione-disulfide reductase [Microcoleus ...   280   4e-73
ref|ZP_05619657.1| glutathione-disulfide reductase [Enhydrobacte...   280   5e-73
ref|ZP_01792982.1| glutathione reductase [Haemophilus influenzae...   280   5e-73
ref|ZP_08149145.1| glutathione-disulfide reductase [Haemophilus ...   279   8e-73
ref|YP_089177.1| glutathione reductase [Mannheimia succiniciprod...   279   8e-73
ref|YP_002152536.1| glutathione reductase [Proteus mirabilis HI4...   278   1e-72
ref|YP_001517987.1| glutathione reductase [Acaryochloris marina ...   278   1e-72
ref|ZP_01797072.1| glutathione reductase [Haemophilus influenzae...   278   1e-72
gb|AAK27157.1|AF349449_1 glutathione reductase [Brassica juncea]      278   1e-72
ref|YP_003743693.1| Glutathione reductase [Erwinia billingiae Eb...   278   1e-72
ref|ZP_01789317.1| glutathione reductase [Haemophilus influenzae...   278   1e-72
ref|YP_004136325.1| glutathione oxidoreductase [Haemophilus infl...   278   2e-72
ref|YP_001290323.1| glutathione reductase [Haemophilus influenza...   278   2e-72
ref|YP_247881.1| glutathione reductase [Haemophilus influenzae 8...   278   2e-72
gb|ADO95917.1| Glutathione oxidoreductase [Haemophilus influenza...   278   2e-72
ref|ZP_01787054.1| glutathione reductase [Haemophilus influenzae...   277   3e-72
ref|YP_001563379.1| glutathione-disulfide reductase [Delftia aci...   277   3e-72
ref|NP_438331.1| glutathione reductase [Haemophilus influenzae R...   277   3e-72
gb|ADI80343.1| glutathione reductase [Chlamydomonas sp. ICE-L]        276   4e-72
ref|YP_001402993.1| glutathione reductase [Yersinia pseudotuberc...   276   4e-72
ref|YP_072299.1| glutathione reductase [Yersinia pseudotuberculo...   276   4e-72
ref|YP_001718880.1| glutathione reductase [Yersinia pseudotuberc...   276   5e-72
ref|YP_001292054.1| glutathione reductase [Haemophilus influenza...   276   5e-72
ref|NP_191026.1| GR (GLUTATHIONE REDUCTASE); ATP binding / gluta...   276   5e-72
emb|CBW28405.1| glutathione oxidoreductase [Haemophilus influenz...   276   7e-72
gb|EDK97525.1| thioredoxin reductase 2, isoform CRA_b [Mus muscu...   276   7e-72
ref|ZP_01784260.1| glutathione reductase [Haemophilus influenzae...   276   7e-72
ref|ZP_01795383.1| Na(+)-translocating NADH-quinone reductase su...   276   7e-72
ref|YP_002985654.1| glutathione-disulfide reductase [Dickeya dad...   275   9e-72
ref|XP_001909415.1| hypothetical protein [Podospora anserina S m...   275   9e-72
ref|ZP_01237274.1| glutathione reductase [Vibrio angustum S14] >...   275   9e-72
ref|ZP_04627945.1| Glutathione reductase [Yersinia bercovieri AT...   275   9e-72
ref|XP_002877994.1| hypothetical protein ARALYDRAFT_485870 [Arab...   275   1e-71
ref|ZP_02958557.1| hypothetical protein PROSTU_00303 [Providenci...   275   1e-71
dbj|BAD27394.1| glutathione reductase [Zinnia violacea]               275   1e-71
ref|ZP_07952866.1| glutathione-disulfide reductase [Enterobacter...   275   1e-71
ref|YP_653712.1| glutathione reductase [Yersinia pestis Antiqua]...   275   1e-71
ref|YP_453748.1| glutathione reductase [Sodalis glossinidius str...   275   1e-71
ref|ZP_01917795.1| glutathione reductase [Yersinia pestis CA88-4...   275   1e-71
ref|NP_671146.1| glutathione reductase [Yersinia pestis KIM 10] ...   275   1e-71
ref|XP_002835172.1| hypothetical protein [Tuber melanosporum Mel...   274   2e-71
ref|YP_001909236.1| glutathione reductase [Erwinia tasmaniensis ...   274   2e-71
ref|YP_002379567.1| glutathione reductase [Cyanothece sp. PCC 74...   274   2e-71
ref|YP_002370657.1| glutathione reductase [Cyanothece sp. PCC 88...   274   2e-71
gb|AAK96868.1| Gluthatione reductase, chloroplast precursor [Ara...   274   2e-71
ref|ZP_04631501.1| Glutathione reductase [Yersinia frederiksenii...   274   2e-71
ref|YP_004138455.1| glutathione oxidoreductase [Haemophilus infl...   274   3e-71
ref|ZP_04640560.1| Glutathione reductase [Yersinia mollaretii AT...   274   3e-71
ref|ZP_02479102.1| aminopeptidase B [Haemophilus parasuis 29755]...   274   3e-71
ref|ZP_04611707.1| Glutathione reductase [Yersinia rohdei ATCC 4...   273   3e-71
ref|NP_246172.1| glutathione reductase [Pasteurella multocida su...   273   3e-71
ref|ZP_04636901.1| Glutathione reductase [Yersinia intermedia AT...   273   3e-71
ref|YP_001345305.1| glutathione reductase [Actinobacillus succin...   273   3e-71
ref|YP_724176.1| glutathione reductase [Trichodesmium erythraeum...   273   3e-71
ref|YP_003554885.1| glutathione reductase [Shewanella violacea D...   273   4e-71
ref|YP_003522067.1| Gor [Pantoea ananatis LMG 20103] >gi|2911543...   273   4e-71
ref|ZP_06192796.1| hypothetical protein SOD_h01970 [Serratia odo...   273   4e-71
ref|ZP_05919188.1| glutathione-disulfide reductase [Pasteurella ...   273   4e-71
ref|YP_003028213.1| glutathione reductase [Streptococcus suis BM...   273   4e-71
ref|YP_002475911.1| glutathione reductase [Haemophilus parasuis ...   273   4e-71
ref|YP_003887325.1| glutathione-disulfide reductase [Cyanothece ...   273   4e-71
ref|ZP_03826978.1| glutathione reductase [Pectobacterium carotov...   273   6e-71
ref|ZP_03319692.1| hypothetical protein PROVALCAL_02638 [Provide...   273   6e-71
ref|ZP_01160380.1| glutathione reductase [Photobacterium sp. SKA...   273   6e-71
ref|ZP_01078137.1| glutathione reductase [Marinomonas sp. MED121...   273   6e-71
ref|YP_003714407.1| glutathione oxidoreductase, nucleotide-bindi...   272   7e-71
ref|ZP_03830608.1| glutathione reductase [Pectobacterium carotov...   272   7e-71
pir||T51908 glutathione-disulfide reductase (EC 1.8.1.7) [simila...   272   7e-71
ref|XP_956448.1| glutathione reductase [Neurospora crassa OR74A]...   272   7e-71
emb|CBX82448.1| glutathione oxidoreductase [Erwinia amylovora AT...   272   1e-70
ref|YP_003932656.1| glutathione oxidoreductase [Pantoea vagans C...   272   1e-70
ref|ZP_06716457.1| glutathione-disulfide reductase [Edwardsiella...   272   1e-70
ref|ZP_06156455.1| glutathione reductase [Photobacterium damsela...   272   1e-70
ref|YP_002924646.1| lipoamide dehydrogenase, E3 component is par...   272   1e-70
ref|ZP_03626118.1| glutathione-disulfide reductase [Streptococcu...   272   1e-70
ref|YP_002281519.1| glutathione reductase [Rhizobium leguminosar...   272   1e-70
ref|ZP_06637767.1| glutathione-disulfide reductase [Serratia odo...   271   1e-70
ref|YP_003024490.1| glutathione reductase [Streptococcus suis SC...   271   1e-70
ref|XP_002108773.1| hypothetical protein TRIADDRAFT_52087 [Trich...   271   1e-70
ref|YP_001200062.1| glutathione reductase [Streptococcus suis 98...   271   1e-70
ref|YP_663759.1| glutathione-disulfide reductase [Pseudoalteromo...   271   1e-70
ref|YP_003885253.1| glutathione oxidoreductase [Dickeya dadantii...   271   2e-70
ref|YP_003469981.1| glutathione oxidoreductase, nucleotide-bindi...   271   2e-70
ref|ZP_05989915.1| glutathione-disulfide reductase [Mannheimia h...   271   2e-70
ref|YP_001471883.1| glutathione reductase [Shewanella sediminis ...   271   2e-70
ref|ZP_07248697.1| glutathione reductase [Streptococcus suis 05H...   271   2e-70
emb|CAY76180.1| glutathione oxidoreductase [Erwinia pyrifoliae D...   271   2e-70
ref|YP_003019736.1| glutathione-disulfide reductase [Pectobacter...   271   2e-70
ref|YP_003008633.1| glutathione reductase [Aggregatibacter aphro...   271   2e-70
ref|ZP_04752888.1| glutathione reductase [Actinobacillus minor N...   271   2e-70
ref|YP_002650515.1| glutathione reductase [Erwinia pyrifoliae Ep...   271   2e-70
ref|YP_002746318.1| glutathione reductase [Streptococcus equi su...   271   2e-70
ref|YP_002123239.1| glutathione reductase [Streptococcus equi su...   271   2e-70
ref|YP_768279.1| glutathione reductase [Rhizobium leguminosarum ...   271   2e-70
ref|ZP_01166092.1| glutathione reductase [Oceanospirillum sp. ME...   271   2e-70
ref|YP_003532896.1| glutathione oxidoreductase [Erwinia amylovor...   270   3e-70
ref|ZP_06635312.1| aminopeptidase B [Aggregatibacter actinomycet...   270   3e-70
ref|ZP_04976741.1| glutathione-disulfide reductase [Mannheimia h...   270   3e-70
gb|AAD28177.1|AF109694_1 glutathione reductase [Brassica juncea]      270   3e-70
ref|ZP_00514499.1| Glutathione reductase, plant [Crocosphaera wa...   270   3e-70
gb|ADP10694.1| glutathione reductase [Erwinia sp. Ejp617]             270   4e-70
ref|ZP_05969851.1| glutathione-disulfide reductase [Enterobacter...   270   4e-70
ref|YP_002544745.1| glutathione-disulfide reductase [Agrobacteri...   270   4e-70
ref|YP_003255074.1| glutathione reductase [Aggregatibacter actin...   270   5e-70
ref|YP_001978597.1| glutathione reductase protein [Rhizobium etl...   270   5e-70
ref|ZP_07895395.1| glutathione-disulfide reductase [Enterococcus...   269   6e-70
ref|ZP_07870189.1| glutathione-disulfide reductase [Listeria mar...   269   6e-70
ref|ZP_04618576.1| Glutathione reductase [Yersinia aldovae ATCC ...   269   6e-70
ref|YP_003039130.1| glutathione reductase [Photorhabdus asymbiot...   269   6e-70
ref|YP_001685169.1| glutathione-disulfide reductase [Caulobacter...   269   6e-70
ref|ZP_06355632.1| glutathione-disulfide reductase [Citrobacter ...   269   8e-70
ref|ZP_04622224.1| Glutathione reductase [Yersinia kristensenii ...   269   8e-70
ref|ZP_05972091.1| glutathione-disulfide reductase [Providencia ...   269   8e-70
ref|YP_002744622.1| glutathione reductase [Streptococcus equi su...   269   8e-70
ref|YP_002236123.1| glutathione-disulfide reductase [Klebsiella ...   269   8e-70
gb|AAB70837.1| glutathione reductase (NADPH) [Vitis vinifera]         269   8e-70
ref|ZP_00229909.1| glutathione reductase [Listeria monocytogenes...   269   8e-70
gb|EFY95687.1| glutathione-disulfide reductase [Metarhizium anis...   268   1e-69
gb|EFY88406.1| glutathione-disulfide reductase [Metarhizium acri...   268   1e-69
ref|XP_002281935.1| PREDICTED: hypothetical protein [Vitis vinif...   268   1e-69
ref|ZP_03667795.1| glutathione reductase [Listeria monocytogenes...   268   1e-69
ref|XP_002294541.1| glutathione reductase, gro-2 [Thalassiosira ...   268   1e-69
ref|YP_001456436.1| glutathione reductase [Citrobacter koseri AT...   268   1e-69
ref|YP_849090.1| glutathione reductase [Listeria welshimeri sero...   268   1e-69
ref|YP_013530.1| glutathione reductase [Listeria monocytogenes s...   268   1e-69
ref|YP_001460294.1| glutathione reductase [Escherichia coli HS] ...   268   1e-69
ref|YP_003437178.1| glutathione-disulfide reductase [Klebsiella ...   268   1e-69
ref|ZP_06013809.1| glutathione-disulfide reductase [Klebsiella p...   268   1e-69
ref|YP_003331617.1| glutathione-disulfide reductase [Dickeya dad...   268   1e-69
ref|YP_003002387.1| glutathione reductase [Dickeya zeae Ech1591]...   268   1e-69
ref|ZP_04654211.1| glutathione reductase [Salmonella enterica su...   268   1e-69
ref|YP_002921709.1| glutathione reductase [Klebsiella pneumoniae...   268   1e-69
ref|ZP_04559308.1| glutathione reductase [Citrobacter sp. 30_2] ...   268   1e-69
ref|XP_002520986.1| glutathione reductase, putative [Ricinus com...   268   1e-69
ref|YP_001806040.1| glutathione reductase [Cyanothece sp. ATCC 5...   268   1e-69
ref|NP_417957.1| glutathione oxidoreductase [Escherichia coli st...   268   1e-69
ref|YP_001464965.1| glutathione reductase [Escherichia coli E243...   268   1e-69
gb|EFR85215.1| glutathione-disulfide reductase [Listeria monocyt...   268   2e-69
ref|YP_003626426.1| glutathione-disulfide reductase [Moraxella c...   268   2e-69
emb|CBK86194.1| NADPH-glutathione reductase [Enterobacter cloaca...   268   2e-69
ref|YP_003615390.1| glutathione reductase [Enterobacter cloacae ...   268   2e-69
ref|ZP_06727687.1| glutathione-disulfide reductase [Acinetobacte...   268   2e-69
ref|ZP_03063396.1| glutathione-disulfide reductase [Shigella dys...   268   2e-69
ref|XP_775436.1| hypothetical protein CNBE1510 [Cryptococcus neo...   268   2e-69
ref|ZP_08039890.1| glutathione oxidoreductase [Serratia symbioti...   267   2e-69
emb|CBI56981.1| unnamed protein product [Sordaria macrospora]         267   2e-69
ref|ZP_07054263.1| glutathione-disulfide reductase [Listeria gra...   267   2e-69
ref|YP_002350671.1| glutathione-disulfide reductase [Listeria mo...   267   2e-69
ref|YP_001480935.1| glutathione reductase [Serratia proteamacula...   267   2e-69
ref|XP_570771.1| glutathione-disulfide reductase [Cryptococcus n...   267   2e-69
ref|NP_470246.1| glutathione reductase [Listeria innocua Clip112...   267   2e-69
gb|EGB61505.1| glutathione-disulfide reductase [Escherichia coli...   267   3e-69
ref|XP_003194185.1| glutathione-disulfide reductase [Cryptococcu...   267   3e-69
ref|ZP_07620910.1| glutathione reductase [Escherichia coli TA280]     267   3e-69
ref|XP_002667762.1| PREDICTED: glutathione reductase-like [Danio...   267   3e-69
ref|ZP_06655586.1| glutathione-disulfide reductase [Escherichia ...   267   3e-69
ref|ZP_05228824.1| glutathione-disulfide reductase [Listeria mon...   267   3e-69
ref|ZP_03612176.1| glutathione reductase [Actinobacillus minor 2...   267   3e-69
ref|YP_002384573.1| glutathione reductase [Escherichia fergusoni...   267   3e-69
ref|YP_001659640.1| glutathione reductase [Microcystis aeruginos...   267   3e-69
ref|ZP_05236781.1| glutathione reductase [Listeria monocytogenes...   267   3e-69
ref|YP_001337520.1| glutathione reductase [Klebsiella pneumoniae...   267   3e-69
ref|YP_001008198.1| glutathione reductase [Yersinia enterocoliti...   267   3e-69
ref|NP_927730.1| glutathione reductase [Photorhabdus luminescens...   267   3e-69
ref|YP_001095785.1| glutathione reductase [Shewanella loihica PV...   267   3e-69
gb|ADZ44270.1| glutathione reductase [Yersinia enterocolitica su...   266   4e-69
dbj|BAJ78609.1| glutathione reductase [Fusarium oxysporum]            266   4e-69
emb|CBY29391.1| glutathione reductase [Yersinia enterocolitica s...   266   4e-69
ref|ZP_07379801.1| glutathione-disulfide reductase [Pantoea sp. ...   266   4e-69
ref|YP_003731785.1| glutathione reductase [Acinetobacter sp. DR1...   266   4e-69
ref|YP_002399991.1| glutathione reductase [Escherichia coli ED1a...   266   4e-69
ref|YP_001440238.1| glutathione reductase [Cronobacter sakazakii...   266   4e-69
ref|NP_312399.1| glutathione reductase [Escherichia coli O157:H7...   266   4e-69
ref|YP_001784403.1| glutathione-disulfide reductase [Haemophilus...   266   4e-69
ref|YP_004210929.1| glutathione-disulfide reductase [Rahnella sp...   266   5e-69
ref|YP_003147724.1| glutathione reductase [Kangiella koreensis D...   266   5e-69
ref|ZP_05232539.1| glutathione reductase [Listeria monocytogenes...   266   5e-69
emb|CAN66042.1| hypothetical protein VITISV_014813 [Vitis vinifera]   266   5e-69
ref|YP_156710.1| glutathione reductase [Idiomarina loihiensis L2...   266   5e-69
ref|NP_709280.1| glutathione reductase [Shigella flexneri 2a str...   266   5e-69
ref|YP_542979.1| glutathione reductase [Escherichia coli UTI89] ...   266   5e-69
gb|EGC96927.1| glutathione reductase [Escherichia fergusonii ECD...   266   7e-69
gb|EFZ74198.1| glutathione-disulfide reductase [Escherichia coli...   266   7e-69
gb|EFU02952.1| glutathione-disulfide reductase [Enterococcus fae...   266   7e-69
ref|YP_003721936.1| glutathione-disulfide reductase ['Nostoc azo...   266   7e-69
ref|ZP_06896769.1| glutathione-disulfide reductase [Roseomonas c...   266   7e-69
dbj|BAI56860.1| glutathione oxidoreductase [Escherichia coli SE15]    266   7e-69
ref|ZP_03824538.1| glutathione reductase [Acinetobacter sp. ATCC...   266   7e-69
ref|ZP_05241749.1| glutathione-disulfide reductase [Listeria mon...   266   7e-69
ref|YP_001882115.1| glutathione reductase [Shigella boydii CDC 3...   266   7e-69

>ref|XP_002896377.1| thioredoxin reductase 1 [Phytophthora infestans T30-4]
 gb|EEY67612.1| thioredoxin reductase 1 [Phytophthora infestans T30-4]
          Length = 856

 Score =  801 bits (2068), Expect = 0.0
 Identities = 389/480 (81%), Positives = 427/480 (88%), Gaps = 6/480 (1%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGLACSKEAA +G+KVCVLDYVKPS  GTSWGLGGTCVNVGCIPKKL
Sbjct: 161 SYDYDLVVIGGGSGGLACSKEAASFGQKVCVLDYVKPSPQGTSWGLGGTCVNVGCIPKKL 220

Query: 61  MHQSSLIGETIHKDSKAFGWTVGE-----QTFDWAQMLKSVNSYIKSINFKYKVELRDKK 115
           MHQSSLIGE +H DS +FGW V         FDW Q++ +V+ YI+ INFKYKVELR K 
Sbjct: 221 MHQSSLIGEVLHHDSASFGWNVSSGQGSAPIFDWKQLVTNVDGYIRGINFKYKVELRSKY 280

Query: 116 VKYENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGGDLAISSDDIFW 175
           VKYEN LGSFID HTLELWHP+KG+K +TTRDVVIAVGGRP+ L   GG+ AISSDDIFW
Sbjct: 281 VKYENFLGSFIDPHTLELWHPRKGSKQITTRDVVIAVGGRPRELTIPGGEHAISSDDIFW 340

Query: 176 RK-EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVES 234
            K + PGKTLVVGASYVALECAGF+KGMGYDVK+MVRSILLRGFDQDMA+KIGE+MEV+S
Sbjct: 341 MKTKEPGKTLVVGASYVALECAGFLKGMGYDVKVMVRSILLRGFDQDMANKIGEYMEVQS 400

Query: 235 KIEFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
            IEFIR  VPQSI KLENGQLLVKWT+ DGE+CEEAFD+VLNATGRDPD+AKL LDKAGV
Sbjct: 401 GIEFIRKTVPQSITKLENGQLLVKWTSEDGESCEEAFDSVLNATGRDPDIAKLDLDKAGV 460

Query: 295 KLNPKTGRIWVENEQTSTPNVYAIGDVIDAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           KLN KTGRIWV++EQTSTPN+YAIGDVIDAPELTPVAIQAGRLL+RRLYNN T  MDYDK
Sbjct: 461 KLNEKTGRIWVKHEQTSTPNIYAIGDVIDAPELTPVAIQAGRLLSRRLYNNATVQMDYDK 520

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           VCTAVFTPIEYGCCGLSEE SI++FG+D +E+YH NF PLEWSLS+ TR AA SCYVKVI
Sbjct: 521 VCTAVFTPIEYGCCGLSEEDSIKRFGKDKIEVYHTNFVPLEWSLSTETRAAAESCYVKVI 580

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           CD+ RDK+VVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMV+ VGIHPTTAE FTTLEVTK
Sbjct: 581 CDRIRDKFVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVDTVGIHPTTAESFTTLEVTK 640


>ref|NP_001025933.2| thioredoxin reductase 1 [Gallus gallus]
          Length = 499

 Score =  518 bits (1335), Expect = e-145
 Identities = 270/482 (56%), Positives = 344/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLA +KEAAKY KKV VLD+V P+ +G SWGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIVIGGGSGGLAAAKEAAKYEKKVMVLDFVTPTPLGNSWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ FGW   E+   +W  M +SV +YI S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRKFGWQFTEEVKHNWMTMTESVQNYIGSLNWGYRVALREKKVTYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F+  HT++  + +   K  T    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGEFVGPHTVKATNKRGVEKLYTAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE+ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQDMANKIGEYME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +   +T D +  EE ++TVL A GRD    K+GLDK GV
Sbjct: 248 IREFVPIKVEQIEEGTPGRLKVTAKSTKDDQVIEEEYNTVLLAIGRDACTRKIGLDKVGV 307

Query: 295 KLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V++ EQT+ P +YAIGD++ D  ELTPVAIQAGRLL +RLY   T   DY
Sbjct: 308 KINEKTGKIPVDDMEQTNVPYIYAIGDILQDRLELTPVAIQAGRLLVQRLYAGSTLKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYG CG SEE +I+KFGE+N+E+YH +F PLEW++ S      + CY K
Sbjct: 368 VNVPTTVFTPLEYGACGYSEENAIQKFGEENIEVYHSHFWPLEWTVPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ V+GFH LGPNAGEVTQ    AMK G T DQ+ + +GIHP  AE+FTTL +
Sbjct: 425 IICNIQDNQRVIGFHVLGPNAGEVTQGFAAAMKCGLTKDQLDSTIGIHPVCAEVFTTLSI 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>pdb|1H6V|A Chain A, Mammalian Thioredoxin Reductase
 pdb|1H6V|B Chain B, Mammalian Thioredoxin Reductase
 pdb|1H6V|C Chain C, Mammalian Thioredoxin Reductase
 pdb|1H6V|D Chain D, Mammalian Thioredoxin Reductase
 pdb|1H6V|E Chain E, Mammalian Thioredoxin Reductase
 pdb|1H6V|F Chain F, Mammalian Thioredoxin Reductase
          Length = 499

 Score =  513 bits (1320), Expect = e-143
 Identities = 270/483 (55%), Positives = 344/483 (71%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT+WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KVIC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLS 483

Query: 472 VTK 474
           VTK
Sbjct: 484 VTK 486


>pdb|3EAN|A Chain A, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|B Chain B, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|C Chain C, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|D Chain D, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|E Chain E, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|F Chain F, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAO|A Chain A, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|B Chain B, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|C Chain C, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|D Chain D, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|E Chain E, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|F Chain F, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
          Length = 499

 Score =  512 bits (1318), Expect = e-143
 Identities = 270/483 (55%), Positives = 343/483 (71%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KVIC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLS 483

Query: 472 VTK 474
           VTK
Sbjct: 484 VTK 486


>gb|EDM17072.1| thioredoxin reductase 1, isoform CRA_b [Rattus norvegicus]
 gb|EDM17073.1| thioredoxin reductase 1, isoform CRA_b [Rattus norvegicus]
          Length = 497

 Score =  511 bits (1317), Expect = e-143
 Identities = 269/483 (55%), Positives = 343/483 (71%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KV+C+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLS 483

Query: 472 VTK 474
           VTK
Sbjct: 484 VTK 486


>gb|EDM17071.1| thioredoxin reductase 1, isoform CRA_a [Rattus norvegicus]
          Length = 611

 Score =  511 bits (1317), Expect = e-143
 Identities = 269/483 (55%), Positives = 343/483 (71%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 124 SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 183

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 184 MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 242

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 243 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 302

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 303 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 361

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 362 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 420

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 421 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 480

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 481 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 537

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KV+C+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 538 KVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLS 597

Query: 472 VTK 474
           VTK
Sbjct: 598 VTK 600


>gb|AAH85726.1| Txnrd1 protein [Rattus norvegicus]
          Length = 578

 Score =  511 bits (1317), Expect = e-143
 Identities = 269/483 (55%), Positives = 343/483 (71%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 91  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 150

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 151 MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 209

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 210 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 269

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 270 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 328

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 329 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 387

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 388 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 447

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 448 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 504

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KV+C+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 505 KVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLS 564

Query: 472 VTK 474
           VTK
Sbjct: 565 VTK 567


>ref|NP_777050.1| thioredoxin reductase 1, cytoplasmic [Bos taurus]
 sp|O62768|TRXR1_BOVIN RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
 gb|AAC13914.1| thioredoxin reductase [Bos taurus]
 gb|DAA29739.1| thioredoxin reductase 1 [Bos taurus]
          Length = 499

 Score =  511 bits (1317), Expect = e-143
 Identities = 267/482 (55%), Positives = 344/482 (71%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAAKY KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAAKYDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 70

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW V E    DW +M ++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 71  HQAALLGQAL-RDSRNYGWNVEETVKHDWERMTEAVQNHIGSLNWGYRVALREKKVTYEN 129

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 130 AYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC 189

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE M+ E  I+FI
Sbjct: 190 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMQ-EHGIKFI 248

Query: 240 RGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           R  VP  + ++E G     +++ K T +D +  E  ++TVL A GRD    K+GL+  GV
Sbjct: 249 RQFVPIKVEQIEAGTPGRLRVIAKSTDSD-QTIEGEYNTVLLAIGRDACTRKIGLENVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V E EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTEEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGSCGLSEEKAVEKFGEENVEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           V+C+   ++ VVGFH LGPNAGEVTQ    A+K G T DQ+ + +GIHP  AE+FTTL V
Sbjct: 425 VVCNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|NP_113802.2| thioredoxin reductase 1, cytoplasmic [Rattus norvegicus]
          Length = 499

 Score =  511 bits (1317), Expect = e-143
 Identities = 269/483 (55%), Positives = 343/483 (71%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KV+C+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLS 483

Query: 472 VTK 474
           VTK
Sbjct: 484 VTK 486


>dbj|BAE26918.1| unnamed protein product [Mus musculus]
          Length = 497

 Score =  511 bits (1317), Expect = e-143
 Identities = 270/482 (56%), Positives = 338/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW V +    DW +M +SV S+I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  I ++E G      +   +T   E  E  F+TVL A GRD     +GL+  GV
Sbjct: 248 IRQFVPTKIERIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           D V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 DNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   D+ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL V
Sbjct: 425 IICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|XP_002798903.1| PREDICTED: thioredoxin reductase 1, cytoplasmic [Macaca mulatta]
          Length = 596

 Score =  511 bits (1316), Expect = e-143
 Identities = 269/482 (55%), Positives = 342/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 109 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 169 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 227

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 228 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 287

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA KIGE ME E  I+F
Sbjct: 288 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMASKIGEHME-EHGIKF 346

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  I ++E G      +V  +T   E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 347 IRQFVPIKIEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGLETVGV 406

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 407 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 466

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 467 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 523

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 524 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 583

Query: 473 TK 474
           TK
Sbjct: 584 TK 585


>ref|XP_002181543.1| predicted protein [Phaeodactylum tricornutum CCAP 1055/1]
 gb|EEC46757.1| predicted protein [Phaeodactylum tricornutum CCAP 1055/1]
          Length = 630

 Score =  511 bits (1316), Expect = e-143
 Identities = 260/492 (52%), Positives = 335/492 (68%), Gaps = 26/492 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGG+A +KEAA  G KV  LD+VKPS  GT+WGLGGTCVNVGCIPKKL 
Sbjct: 135 YDYDLVVIGGGSGGMAAAKEAAVLGAKVACLDFVKPSPAGTTWGLGGTCVNVGCIPKKLF 194

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT------------------FDWAQMLKSVNSYIKSI 103
           H  SL+ E++ KD+ +FG  +GE                      W  + +++ +YI+ +
Sbjct: 195 HIGSLLHESVRKDTPSFGIRLGEPNGASATDELSGIVPDPSTQMRWELVRENIQNYIRGL 254

Query: 104 NFKYKVELRDKKVKYENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG 163
           NFKY+V LR+K+V Y N L  F D HT+E    K  +  +T    ++AVGGRP PL+CEG
Sbjct: 255 NFKYRVRLREKEVTYFNKLAKFTDKHTIEAVDKKGRSSLITAARFLVAVGGRPSPLSCEG 314

Query: 164 GDLAISSDDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMA 223
            + AISSDD+F  ++ PGKTL VGASY++LECAGF+ GMG DV + VRSILLRGFD++ A
Sbjct: 315 AEHAISSDDVFAMEKCPGKTLCVGASYISLECAGFLAGMGLDVTVAVRSILLRGFDRECA 374

Query: 224 DKIGEFMEVESKIEFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPD 283
           DKIG++M V+  + F R  +P  + K+E GQ  V ++    +  EE +DTVL A GR  D
Sbjct: 375 DKIGDYM-VDHGVRFKRDVIPSKLEKIETGQTKVLFS----DGTEEVYDTVLAAVGRMAD 429

Query: 284 VAKLGLDKAGVKLNPKTGRIWVENEQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRL 342
             KLGL+  GV+ NPK  RI  + EQT  PN+YAIGDV+D  PELTPVAIQAG  LARRL
Sbjct: 430 TDKLGLESVGVETNPKNRRIIGKFEQTHCPNIYAIGDVLDKTPELTPVAIQAGLYLARRL 489

Query: 343 YNNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSAT 402
           +  +   MDY  VCT VFTPIEY C GLSEE ++ K+G++N+E+YH+ F PLEWSLS + 
Sbjct: 490 FGGDKEAMDYQNVCTTVFTPIEYACVGLSEEDAVAKYGQNNIEVYHREFVPLEWSLSMSR 549

Query: 403 RPAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPT 462
             + ++ Y KVI DKS  + V+G HY+GPNAGEV Q  G +MK G T   + + VGIHPT
Sbjct: 550 --SHNAAYTKVIVDKSPQENVLGIHYVGPNAGEVMQGYGTSMKQGLTLKTLTDTVGIHPT 607

Query: 463 TAEIFTTLEVTK 474
           ++E   TL +TK
Sbjct: 608 SSEEIVTLSITK 619


>ref|NP_001116141.1| thioredoxin reductase 1, cytoplasmic [Pan troglodytes]
          Length = 499

 Score =  511 bits (1316), Expect = e-143
 Identities = 268/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>gb|EDL21377.1| thioredoxin reductase 1, isoform CRA_b [Mus musculus]
          Length = 611

 Score =  511 bits (1316), Expect = e-143
 Identities = 270/482 (56%), Positives = 338/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 124 SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 183

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW V +    DW +M +SV S+I S+N+ Y+V LR+KKV YE
Sbjct: 184 MHQAALLGQAL-KDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYE 242

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 243 NAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 302

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 303 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 361

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  I ++E G      +   +T   E  E  F+TVL A GRD     +GL+  GV
Sbjct: 362 IRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGV 421

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY
Sbjct: 422 KINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDY 481

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           D V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 482 DNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYAK 538

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   D+ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL V
Sbjct: 539 IICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSV 598

Query: 473 TK 474
           TK
Sbjct: 599 TK 600


>gb|AAH37643.1| Thioredoxin reductase 1 [Mus musculus]
 dbj|BAE40292.1| unnamed protein product [Mus musculus]
 gb|EDL21375.1| thioredoxin reductase 1, isoform CRA_a [Mus musculus]
 gb|EDL21376.1| thioredoxin reductase 1, isoform CRA_a [Mus musculus]
          Length = 497

 Score =  511 bits (1316), Expect = e-143
 Identities = 270/482 (56%), Positives = 338/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW V +    DW +M +SV S+I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  I ++E G      +   +T   E  E  F+TVL A GRD     +GL+  GV
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           D V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 DNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   D+ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL V
Sbjct: 425 IICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|NP_001035988.1| thioredoxin reductase 1, cytoplasmic isoform 1 [Mus musculus]
 sp|Q9JMH6|TRXR1_MOUSE RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
 gb|AAK01140.1|AF333036_1 thioredoxin reductase 1 [Mus musculus]
          Length = 613

 Score =  511 bits (1316), Expect = e-143
 Identities = 270/482 (56%), Positives = 338/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 124 SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 183

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW V +    DW +M +SV S+I S+N+ Y+V LR+KKV YE
Sbjct: 184 MHQAALLGQAL-KDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYE 242

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 243 NAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 302

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 303 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 361

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  I ++E G      +   +T   E  E  F+TVL A GRD     +GL+  GV
Sbjct: 362 IRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGV 421

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY
Sbjct: 422 KINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDY 481

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           D V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 482 DNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYAK 538

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   D+ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL V
Sbjct: 539 IICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSV 598

Query: 473 TK 474
           TK
Sbjct: 599 TK 600


>ref|NP_056577.2| thioredoxin reductase 1, cytoplasmic isoform 2 [Mus musculus]
 ref|NP_001035978.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Mus musculus]
 ref|NP_001035979.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Mus musculus]
 dbj|BAA86985.2| thioredoxin reductase 1 [Mus musculus]
          Length = 499

 Score =  511 bits (1316), Expect = e-143
 Identities = 270/482 (56%), Positives = 338/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW V +    DW +M +SV S+I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  I ++E G      +   +T   E  E  F+TVL A GRD     +GL+  GV
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           D V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 DNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   D+ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL V
Sbjct: 425 IICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>sp|Q5NVA2|TRXR1_PONAB RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
          Length = 499

 Score =  511 bits (1315), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL+VGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|XP_001744219.1| hypothetical protein [Monosiga brevicollis MX1]
 gb|EDQ90922.1| predicted protein [Monosiga brevicollis MX1]
          Length = 506

 Score =  511 bits (1315), Expect = e-142
 Identities = 258/477 (54%), Positives = 348/477 (72%), Gaps = 11/477 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLA SKEAA  G K  VLD+V+PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 26  FDYDLVVVGGGSGGLAASKEAASLGAKTAVLDFVQPSPQGTTWGLGGTCVNVGCIPKKLM 85

Query: 62  HQSSLIGETIHKDSKAFGWTVGE-QTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ+++IG TI +D+ +FGW +   +  +W+ +++ V ++I+S+N+ Y+V LRDK V Y N
Sbjct: 86  HQAAIIGHTI-EDATSFGWDLQRPEKPNWSTLVEGVQNHIRSLNWGYRVALRDKNVTYLN 144

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             GS +DAHT+   + +   + +T   +++  GGRP+     G  +  I+SDDIF     
Sbjct: 145 AYGSLLDAHTINTVNKRGKEQVITADKIILCPGGRPRYPDIPGAKEFGITSDDIFSLDRE 204

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLV+GASYVALECAGF+   GYD  +MVRSILLRGFD ++A KIG+ ME  + ++F+
Sbjct: 205 PGKTLVIGASYVALECAGFLAAFGYDTTVMVRSILLRGFDSEIAQKIGDHMERHAHVKFV 264

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           R   P  I K E+G+L+V + T +GEA  + FDTVL A GRD   + +GLDKAGV+LN +
Sbjct: 265 RQATPDRIEKREDGRLVVHY-TQNGEAVSDEFDTVLFAIGRDACTSTMGLDKAGVQLNER 323

Query: 300 TGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            G++   E +QT+ PN+YAIGDV++  PELTPVAIQAG+LLARRLY     LMDY  VCT
Sbjct: 324 NGKVVANEADQTNVPNIYAIGDVLEGKPELTPVAIQAGKLLARRLYGQSAALMDYQNVCT 383

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGCCG SE+ ++++FGED +E++HQ+FTPLEW++    RP  + C+ K++  K
Sbjct: 384 TVFTPLEYGCCGFSEDDALDQFGED-IEVFHQSFTPLEWTVPH--RP-ENVCFCKLVVQK 439

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           S D+ V+G H+LGPNAGEVTQ  G+A+KL  T  Q  ++VGIHPT AE  TT+++TK
Sbjct: 440 STDR-VLGLHFLGPNAGEVTQGFGMALKLKATKAQFDDLVGIHPTVAETLTTMDITK 495


>pdb|2ZZ0|A Chain A, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZ0|B Chain B, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZ0|C Chain C, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZ0|D Chain D, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZB|A Chain A, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZB|B Chain B, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZB|C Chain C, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZB|D Chain D, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZC|A Chain A, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
 pdb|2ZZC|B Chain B, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
 pdb|2ZZC|C Chain C, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
 pdb|2ZZC|D Chain D, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
          Length = 513

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 24  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 83

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 84  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 142

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 143 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 202

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 203 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 261

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 262 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 321

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 322 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 381

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 382 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 438

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 439 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 498

Query: 473 TK 474
           TK
Sbjct: 499 TK 500


>dbj|BAH11961.1| unnamed protein product [Homo sapiens]
          Length = 547

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 60  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 119

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 120 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 178

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 179 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 238

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 239 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 297

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 298 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 357

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 358 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 417

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 418 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 474

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 475 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 534

Query: 473 TK 474
           TK
Sbjct: 535 TK 536


>ref|XP_002594765.1| hypothetical protein BRAFLDRAFT_122807 [Branchiostoma floridae]
 gb|EEN50776.1| hypothetical protein BRAFLDRAFT_122807 [Branchiostoma floridae]
          Length = 596

 Score =  510 bits (1314), Expect = e-142
 Identities = 261/479 (54%), Positives = 340/479 (70%), Gaps = 11/479 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA SKEA K+GKKV V D+VKPS +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 112 YDYDLIVIGGGSGGLAASKEAGKFGKKVLVCDFVKPSPIGTTWGLGGTCVNVGCIPKKLM 171

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G +I +DS+ FGW V E+   +W  M +++ +YI S+N+ Y+V LRDK VKYEN
Sbjct: 172 HQAALLGHSI-EDSRKFGWEVSEEVKHNWHTMKEAIQNYIGSLNWGYRVALRDKGVKYEN 230

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
               F+D HT++  + +    T T    ++AVG RP+     G  +  I+SDD+F     
Sbjct: 231 AYAEFVDPHTIKTVNRRGKENTATAERFLVAVGMRPRYPDIPGAKEYGITSDDLFSLPYC 290

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLV+GASYVALECAGF++G+G D  +MVRSILLRGFDQ MADK+G +ME +  ++FI
Sbjct: 291 PGKTLVIGASYVALECAGFLRGIGLDTTVMVRSILLRGFDQQMADKVGAYME-KGGMKFI 349

Query: 240 RGCVPQSIMKLENGQ--LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           RGCVP  + +LE GQ   L      DG+      +T+L   GRD     + L+KAGV+ N
Sbjct: 350 RGCVPTKVERLEEGQPGKLRVTGMQDGKEVVWEGNTILFGIGRDACTEGIHLEKAGVQFN 409

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
            K G+I+  + EQT+ P++YAIGDV++   ELTPVAIQAG+LLA+RLY    T  DY  V
Sbjct: 410 TKNGKIYGNDVEQTNQPHIYAIGDVLEGKLELTPVAIQAGKLLAQRLYGGAQTKTDYINV 469

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYG CGLSEE +I K+GEDN+E+YH NF PLEW++        + CY K++C
Sbjct: 470 PTTVFTPLEYGACGLSEEDAIAKYGEDNIEVYHSNFQPLEWTVPGHD---VNDCYAKILC 526

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           ++  ++ VVGFH LGPNAGE+TQ  G AMK G T  Q+   +GIHPT AEIFTT+++TK
Sbjct: 527 NRQDNERVVGFHVLGPNAGEITQGYGAAMKCGMTKAQLDTTIGIHPTNAEIFTTMDITK 585


>pdb|2J3N|A Chain A, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|B Chain B, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|C Chain C, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|D Chain D, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|E Chain E, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|F Chain F, X-Ray Structure Of Human Thioredoxin Reductase 1
          Length = 519

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 30  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 89

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 90  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 148

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 149 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 208

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 209 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 267

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 268 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 327

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 328 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 387

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 388 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 444

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 445 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 504

Query: 473 TK 474
           TK
Sbjct: 505 TK 506


>ref|NP_001087240.1| thioredoxin reductase 1, cytoplasmic isoform 3 [Homo sapiens]
 sp|Q16881|TRXR1_HUMAN RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Gene associated with retinoic and
           interferon-induced mortality 12 protein; Short=GRIM-12;
           Short=Gene associated with retinoic and IFN-induced
           mortality 12 protein; AltName: Full=KM-102-derived
           reductase-like factor; AltName: Full=Thioredoxin
           reductase TR1
          Length = 649

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 160 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 219

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 220 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 278

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 279 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 338

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 339 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 397

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 398 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 457

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 458 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 517

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 518 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 574

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 575 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 634

Query: 473 TK 474
           TK
Sbjct: 635 TK 636


>ref|NP_003321.3| thioredoxin reductase 1, cytoplasmic isoform 1 [Homo sapiens]
          Length = 551

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 62  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 121

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 122 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 180

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 181 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 240

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 241 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 299

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 300 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 359

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 360 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 419

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 420 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 476

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 477 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 536

Query: 473 TK 474
           TK
Sbjct: 537 TK 538


>gb|EAW97743.1| thioredoxin reductase 1 [Homo sapiens]
 gb|EAW97744.1| thioredoxin reductase 1 [Homo sapiens]
          Length = 623

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 136 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 195

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 196 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 254

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 255 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 314

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 315 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 373

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 374 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 433

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 434 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 493

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 494 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 550

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 551 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 610

Query: 473 TK 474
           TK
Sbjct: 611 TK 612


>gb|EAW97745.1| thioredoxin reductase 1 [Homo sapiens]
 dbj|BAH14140.1| unnamed protein product [Homo sapiens]
          Length = 647

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 160 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 219

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 220 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 278

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 279 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 338

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 339 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 397

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 398 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 457

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 458 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 517

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 518 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 574

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 575 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 634

Query: 473 TK 474
           TK
Sbjct: 635 TK 636


>pdb|2CFY|A Chain A, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|B Chain B, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|C Chain C, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|D Chain D, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|E Chain E, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|F Chain F, Crystal Structure Of Human Thioredoxin Reductase 1
          Length = 521

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 32  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 91

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 92  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 150

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 151 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 210

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 211 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 269

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 270 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 329

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 330 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 389

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 390 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 446

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 447 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 506

Query: 473 TK 474
           TK
Sbjct: 507 TK 508


>emb|CAA04503.1| thioredoxin reductase [Homo sapiens]
 gb|AAV38446.1| thioredoxin reductase 1 [Homo sapiens]
 gb|AAZ67916.1| thioredoxin reductase 1 [Homo sapiens]
 dbj|BAG35193.1| unnamed protein product [Homo sapiens]
          Length = 497

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|NP_877393.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Homo sapiens]
 ref|NP_877419.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Homo sapiens]
 ref|NP_877420.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Homo sapiens]
 gb|AAH18122.2| Thioredoxin reductase 1 [Homo sapiens]
          Length = 499

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>dbj|BAA13674.1| KM-102-derived reductase-like factor [Homo sapiens]
          Length = 549

 Score =  510 bits (1314), Expect = e-142
 Identities = 267/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 62  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 121

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 122 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 180

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 181 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 240

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 241 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 299

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 300 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 359

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 360 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 419

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 420 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 476

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 477 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 536

Query: 473 TK 474
           TK
Sbjct: 537 TK 538


>ref|NP_001131081.1| thioredoxin reductase 1 [Equus caballus]
          Length = 499

 Score =  510 bits (1313), Expect = e-142
 Identities = 268/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAAKY KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAKYNKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M ++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-RDSRNYGWNVEEMVKHDWEKMTEAVQNHIGSLNWGYRVALREKKVTYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKTTNNKGKEKIYSAEKFLIATGERPRYLDIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  ++F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGVKF 247

Query: 239 IRGCVPQSIMKLE---NGQL-LVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           I+  VP  + ++E    GQL +V  +T   E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 248 IKQFVPIKVEQIEAGTPGQLRVVAQSTKGDETIEGEYNTVLLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEENAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL V
Sbjct: 425 IICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|XP_002752975.1| PREDICTED: thioredoxin reductase 1, cytoplasmic isoform 2
           [Callithrix jacchus]
          Length = 549

 Score =  509 bits (1312), Expect = e-142
 Identities = 266/481 (55%), Positives = 342/481 (71%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKLM
Sbjct: 63  YDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 122

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 123 HQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYEN 181

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 182 AYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC 241

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTL+VGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+FI
Sbjct: 242 PGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKFI 300

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + ++E G      +V  +T + E  E  ++TVL A GRD    K+GL+  GVK
Sbjct: 301 RQFVPIKVEQIEAGTPGRLRVVAQSTNNEEIIEGEYNTVLLAIGRDACTRKIGLETVGVK 360

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   DY+
Sbjct: 361 INEKTGKIPVTDEEQTNVPYIYAIGDILEGKVELTPVAIQAGRLLAQRLYAGSTVKCDYE 420

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K+
Sbjct: 421 NVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAKI 477

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+    + VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL VT
Sbjct: 478 ICNTKDSERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 537

Query: 474 K 474
           K
Sbjct: 538 K 538


>ref|XP_002752974.1| PREDICTED: thioredoxin reductase 1, cytoplasmic isoform 1
           [Callithrix jacchus]
          Length = 649

 Score =  509 bits (1312), Expect = e-142
 Identities = 266/481 (55%), Positives = 342/481 (71%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKLM
Sbjct: 163 YDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 222

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 223 HQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYEN 281

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 282 AYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC 341

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTL+VGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+FI
Sbjct: 342 PGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKFI 400

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + ++E G      +V  +T + E  E  ++TVL A GRD    K+GL+  GVK
Sbjct: 401 RQFVPIKVEQIEAGTPGRLRVVAQSTNNEEIIEGEYNTVLLAIGRDACTRKIGLETVGVK 460

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   DY+
Sbjct: 461 INEKTGKIPVTDEEQTNVPYIYAIGDILEGKVELTPVAIQAGRLLAQRLYAGSTVKCDYE 520

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K+
Sbjct: 521 NVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAKI 577

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+    + VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL VT
Sbjct: 578 ICNTKDSERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 637

Query: 474 K 474
           K
Sbjct: 638 K 638


>emb|CAG38744.1| TXNRD1 [Homo sapiens]
          Length = 497

 Score =  509 bits (1311), Expect = e-142
 Identities = 266/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    ++GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRRIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|XP_003126688.1| PREDICTED: thioredoxin reductase 1, cytoplasmic-like [Sus scrofa]
          Length = 497

 Score =  508 bits (1309), Expect = e-142
 Identities = 264/482 (54%), Positives = 343/482 (71%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA++ K+V VLD+V P+ +GT WGLGGTCVNVGCIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 70

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW V E    DW +M ++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 71  HQAALLGQAL-RDSRNYGWNVEETIKHDWERMTEAVQNHIGSLNWGYRVALREKKVTYEN 129

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 130 AYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC 189

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  ++FI
Sbjct: 190 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGVKFI 248

Query: 240 RGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           R  VP  + ++E G     ++  K T +D E  E  ++TVL A GRD     +GL+  GV
Sbjct: 249 RQFVPIKVEQIEAGMPGRLRVTAKATNSD-ETIEGEYNTVLLAIGRDACTRNIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           ++N KTG+I V + EQT+ P VYAIGD+++  PELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 EINEKTGKIPVTDEEQTNVPYVYAIGDILEGKPELTPVAIQAGRLLAQRLYGGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+EIYH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEIYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           ++C+   ++ VVGFH LGPNAGEVTQ    A+K G T DQ+ + +GIHP  AE+FTTL V
Sbjct: 425 IVCNIKDNERVVGFHILGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|XP_001507796.1| PREDICTED: similar to thioredoxin reductase 1 [Ornithorhynchus
           anatinus]
          Length = 621

 Score =  508 bits (1309), Expect = e-142
 Identities = 270/482 (56%), Positives = 339/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           ++DYDL+VIGGGSGGLA +KEAAKYGKKV VLD+V P+ +G  WGLGGTCVNVGCIPKKL
Sbjct: 134 SFDYDLIVIGGGSGGLAAAKEAAKYGKKVMVLDFVTPTPLGNRWGLGGTCVNVGCIPKKL 193

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    +W  M ++V +YI S+N+ Y+V LR+ KV YE
Sbjct: 194 MHQAALLGQAL-QDSRKYGWQVEETVKHNWESMTEAVQNYIGSLNWGYRVALRENKVTYE 252

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F+  H ++  + K      T    +IA G RP+ L   G     ISSDD+F    
Sbjct: 253 NAYGEFVGPHKIKATNQKGKENFYTAEKFLIATGERPRYLGIPGDKKYCISSDDLFSLPY 312

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 313 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 371

Query: 239 IRGCVPQSIMKLEN---GQLLVKWTTADG-EACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           I+  VP  I ++E    G+L V   + DG E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 372 IKKFVPIKIEQIEEGMPGKLKVVAQSTDGQETIEGEYNTVLLAVGRDSCTRKIGLENVGV 431

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGDV++   ELTPVAIQAGRLLARRLY+  T   DY
Sbjct: 432 KINEKTGKIPVTDEEQTNVPYIYAIGDVLEGKLELTPVAIQAGRLLARRLYSGSTVKCDY 491

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           D V T VFTP+EYG CG SEE + EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 492 DNVPTTVFTPLEYGACGFSEEKAAEKFGEENIEVYHSYFWPLEWTVPSRDN---NKCYAK 548

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T +Q+ + +GIHP  AEIFTTL V
Sbjct: 549 IICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKEQLDSTIGIHPVCAEIFTTLTV 608

Query: 473 TK 474
           TK
Sbjct: 609 TK 610


>ref|NP_898895.2| thioredoxin reductase 3 [Danio rerio]
          Length = 602

 Score =  508 bits (1309), Expect = e-142
 Identities = 270/482 (56%), Positives = 339/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPQGTAWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G T  +D++ FGW   EQ T +W  M  +VN+YI S+N+ Y+V LRDK V Y N
Sbjct: 174 HQTALLG-TAMEDARKFGWEFAEQVTHNWETMKTAVNNYIGSLNWGYRVSLRDKNVNYVN 232

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
               F++ H ++  + K+G +T  T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 233 AYAEFVEPHKIKATN-KRGKETFYTAAQFVLATGERPRYLGIPGDKEFCITSDDLFSLPY 291

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALEC GF+ G+G DV IMVRSILLRGFDQDMAD+ GE+ME    ++F
Sbjct: 292 CPGKTLVVGASYVALECGGFLAGLGLDVTIMVRSILLRGFDQDMADRAGEYMETHG-VKF 350

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           +R  VP  I +LE G      +   +T   E  E  ++TVL A GRD    K+GLDKAGV
Sbjct: 351 LRKFVPTKIEQLEAGTPGRIKVTAKSTESEEVFEGEYNTVLIAVGRDACTGKIGLDKAGV 410

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G++ V + EQT+ P++YAIGD+++   ELTPVAIQAG+LLARRLY   T   DY
Sbjct: 411 KINEKNGKVPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYAGATMKCDY 470

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYG CG  EE +I+ +G++NLE+YH  F PLE+++        + CY K
Sbjct: 471 VNVPTTVFTPMEYGSCGHPEEKAIQMYGQENLEVYHSLFWPLEFTVPGRDN---NKCYAK 527

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  +  V+GFHYLGPNAGEVTQ  G AMK G T DQ+ N +GIHPT AEIFTT+EV
Sbjct: 528 IICNKLDNLRVIGFHYLGPNAGEVTQGFGAAMKCGITKDQLDNTIGIHPTCAEIFTTMEV 587

Query: 473 TK 474
           TK
Sbjct: 588 TK 589


>gb|AAL15432.1| thioredoxin reductase 1 [Homo sapiens]
          Length = 647

 Score =  508 bits (1309), Expect = e-142
 Identities = 266/482 (55%), Positives = 342/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 160 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 219

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 220 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 278

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 279 NAYGQFIGPHRIKATNNKGKEKIYSAESFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 338

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G  V +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 339 CPGKTLVVGASYVALECAGFLAGIGLGVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 397

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 398 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 457

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 458 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 517

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 518 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 574

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 575 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 634

Query: 473 TK 474
           TK
Sbjct: 635 TK 636


>gb|AAB35418.1| thioredoxin reductase [Homo sapiens]
 emb|CAA62629.1| thioredoxin reductase (NADPH) [Homo sapiens]
          Length = 497

 Score =  508 bits (1309), Expect = e-142
 Identities = 266/482 (55%), Positives = 342/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAESFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G  V +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLGVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>gb|AAC69621.1| thioredoxin reductase GRIM-12 [Homo sapiens]
          Length = 497

 Score =  508 bits (1309), Expect = e-142
 Identities = 266/482 (55%), Positives = 343/482 (71%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G +V +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLNVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>gb|AAH54599.1| Thioredoxin reductase 1 [Danio rerio]
 gb|AAI65853.1| Txnrd1 protein [Danio rerio]
          Length = 600

 Score =  508 bits (1309), Expect = e-142
 Identities = 270/482 (56%), Positives = 339/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPQGTAWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G T  +D++ FGW   EQ T +W  M  +VN+YI S+N+ Y+V LRDK V Y N
Sbjct: 174 HQTALLG-TAMEDARKFGWEFAEQVTHNWETMKTAVNNYIGSLNWGYRVSLRDKNVNYVN 232

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
               F++ H ++  + K+G +T  T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 233 AYAEFVEPHKIKATN-KRGKETFYTAAQFVLATGERPRYLGIPGDKEFCITSDDLFSLPY 291

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALEC GF+ G+G DV IMVRSILLRGFDQDMAD+ GE+ME    ++F
Sbjct: 292 CPGKTLVVGASYVALECGGFLAGLGLDVTIMVRSILLRGFDQDMADRAGEYMETHG-VKF 350

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           +R  VP  I +LE G      +   +T   E  E  ++TVL A GRD    K+GLDKAGV
Sbjct: 351 LRKFVPTKIEQLEAGTPGRIKVTAKSTESEEVFEGEYNTVLIAVGRDACTGKIGLDKAGV 410

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G++ V + EQT+ P++YAIGD+++   ELTPVAIQAG+LLARRLY   T   DY
Sbjct: 411 KINEKNGKVPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYAGATMKCDY 470

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYG CG  EE +I+ +G++NLE+YH  F PLE+++        + CY K
Sbjct: 471 VNVPTTVFTPMEYGSCGHPEEKAIQMYGQENLEVYHSLFWPLEFTVPGRDN---NKCYAK 527

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  +  V+GFHYLGPNAGEVTQ  G AMK G T DQ+ N +GIHPT AEIFTT+EV
Sbjct: 528 IICNKLDNLRVIGFHYLGPNAGEVTQGFGAAMKCGITKDQLDNTIGIHPTCAEIFTTMEV 587

Query: 473 TK 474
           TK
Sbjct: 588 TK 589


>gb|AAI67349.1| MGC147163 protein [Xenopus (Silurana) tropicalis]
          Length = 596

 Score =  508 bits (1307), Expect = e-141
 Identities = 262/483 (54%), Positives = 342/483 (70%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYDL+VIGGGSGGLACSKEAA +GKKV VLDYV P+  GTSWGLGGTCVNVGCIPKKL
Sbjct: 109 TYDYDLIVIGGGSGGLACSKEAASFGKKVMVLDYVVPTPKGTSWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++++G+++ KDS+ FGW   EQ   +W  M +++ +YI S+N+ Y+V LRDK+V+YE
Sbjct: 169 MHQAAILGQSL-KDSRNFGWEYEEQVKHNWDTMREAIQNYIGSLNWGYRVSLRDKQVRYE 227

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F++ H ++  + +      T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 228 NAYGEFVEPHKIKATNKRGKESFFTAEKFVVATGERPRYLNIPGDKEYCITSDDLFSLPY 287

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G D  +MVRSILLRGFDQ+MA++ G +ME    ++F
Sbjct: 288 CPGKTLVVGASYVALECAGFLAGLGLDATVMVRSILLRGFDQEMANRAGAYMETHG-VKF 346

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           I+  VP S+  LE G     ++  K T  D +  E+ ++TVL A GRD     +GL+K G
Sbjct: 347 IKQFVPISVELLEEGTPGRLKVTAKATEGD-QIIEDEYNTVLIAVGRDACTRNIGLEKIG 405

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N + G+I V + EQTS P VYAIGD++D   ELTPVAIQAGRLLARRLY       D
Sbjct: 406 VKVNERNGKIPVSDEEQTSVPYVYAIGDILDGKLELTPVAIQAGRLLARRLYKGSKLKCD 465

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCG +EE +IE +GE+NLE+YH  F PLEW++ S      ++C+ 
Sbjct: 466 YVNVPTTVFTPLEYGCCGYAEEKAIEIYGEENLEVYHTLFWPLEWTVPSRDN---NTCFA 522

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K  D  VVGFH LGPNAGE+TQ  G A+K G T +++   +GIHPT AE+FTT++
Sbjct: 523 KIICNKQDDDRVVGFHVLGPNAGEITQGFGAAIKCGLTKEKLDETIGIHPTCAEVFTTMD 582

Query: 472 VTK 474
           V+K
Sbjct: 583 VSK 585


>gb|AAI54785.1| Thioredoxin reductase 1 [Danio rerio]
          Length = 602

 Score =  508 bits (1307), Expect = e-141
 Identities = 270/482 (56%), Positives = 339/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPQGTAWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G T  +D++ FGW   EQ T +W  M  +VN+YI S+N+ Y+V LRDK V Y N
Sbjct: 174 HQTALLG-TAMEDARKFGWEFAEQVTHNWETMKTAVNNYIGSLNWGYRVSLRDKNVNYVN 232

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
               F++ H ++  + K+G +T  T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 233 AYAEFVEPHKIKATN-KRGKETFYTAAQFVLATGERPRYLGIPGDKEFCITSDDLFSLPY 291

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALEC GF+ G+G DV IMVRSILLRGFDQDMAD+ GE+ME    ++F
Sbjct: 292 CPGKTLVVGASYVALECGGFLAGLGLDVTIMVRSILLRGFDQDMADRAGEYMETHG-VKF 350

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           +R  VP  I +LE G      +   +T   E  E  ++TVL A GRD    K+GLDKAGV
Sbjct: 351 LRKFVPTKIEQLEAGTPGRIKVTAKSTESEEFFEGEYNTVLIAVGRDACTGKIGLDKAGV 410

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G++ V + EQT+ P++YAIGD+++   ELTPVAIQAG+LLARRLY   T   DY
Sbjct: 411 KINEKNGKVPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYAGATMKCDY 470

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYG CG  EE +I+ +G++NLE+YH  F PLE+++        + CY K
Sbjct: 471 VNVPTTVFTPMEYGSCGHPEEKAIQMYGQENLEVYHSLFWPLEFTVPGRDN---NKCYAK 527

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  +  V+GFHYLGPNAGEVTQ  G AMK G T DQ+ N +GIHPT AEIFTT+EV
Sbjct: 528 IICNKLDNLRVIGFHYLGPNAGEVTQGFGAAMKCGITKDQLDNTIGIHPTCAEIFTTMEV 587

Query: 473 TK 474
           TK
Sbjct: 588 TK 589


>gb|AAC35244.2| thioredoxin reductase [Rattus norvegicus]
          Length = 497

 Score =  508 bits (1307), Expect = e-141
 Identities = 269/483 (55%), Positives = 343/483 (71%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KVIC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLS 483

Query: 472 VTK 474
           VTK
Sbjct: 484 VTK 486


>ref|NP_001127133.1| thioredoxin reductase 1, cytoplasmic [Pongo abelii]
 emb|CAI30275.1| hypothetical protein [Pongo abelii]
          Length = 499

 Score =  508 bits (1307), Expect = e-141
 Identities = 266/482 (55%), Positives = 341/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V + I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNRIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL+VGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 248 IRQFVPVKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
            K
Sbjct: 485 AK 486


>ref|NP_999319.2| thioredoxin reductase 1, cytoplasmic [Sus scrofa]
          Length = 499

 Score =  507 bits (1305), Expect = e-141
 Identities = 263/482 (54%), Positives = 342/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA++ K+V VLD+V P+ +GT WGLGGTCVNVGCIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 70

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW V E    DW +M ++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 71  HQAALLGQAL-RDSRNYGWNVEETIKHDWERMTEAVQNHIGSLNWGYRVALREKKVTYEN 129

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 130 AYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC 189

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  ++FI
Sbjct: 190 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGVKFI 248

Query: 240 RGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           R  VP  + ++E G     ++  K T +D E  E  ++TVL A GRD     +GL+  GV
Sbjct: 249 RQFVPIKVEQIEAGMPGRLRVTAKATNSD-ETIEGEYNTVLLAIGRDACTRNIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           ++N KTG+I V + EQT+ P VY IGD+++  PELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 EINEKTGKIPVTDEEQTNVPYVYTIGDILEGKPELTPVAIQAGRLLAQRLYGGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+EIYH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEIYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           ++C+   ++ VVGFH LGPNAGEVTQ    A+K G T DQ+ + +GIHP  AE+FTTL V
Sbjct: 425 IVCNIKDNERVVGFHILGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|NP_001087786.1| thioredoxin reductase 1 [Xenopus laevis]
 gb|AAH81224.1| MGC85342 protein [Xenopus laevis]
          Length = 531

 Score =  506 bits (1302), Expect = e-141
 Identities = 267/481 (55%), Positives = 338/481 (70%), Gaps = 12/481 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYDL+VIGGGSGGLA SKEAAKYGKKV VLD+V PS +GT WGLGGTCVNVGCIPKKL
Sbjct: 45  TYDYDLIVIGGGSGGLAASKEAAKYGKKVLVLDFVTPSPLGTKWGLGGTCVNVGCIPKKL 104

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+ + + KDS+ +GW + +    +W  M  SV +YI S+NF Y+V L +  VKYE
Sbjct: 105 MHQAALLRQAL-KDSQKYGWQIADNIQHNWETMTDSVQNYIGSLNFNYRVALMENNVKYE 163

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F+  +T++  + +  +K  T    +IA G RP+ L   G  +  I+SDD+F    
Sbjct: 164 NGYGEFVGPNTIKSTNSRGKSKYFTAEKFLIATGERPRYLGIPGDKEYCITSDDLFSLTY 223

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQ MA+KIGE+ME E  ++F
Sbjct: 224 CPGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQQMANKIGEYME-EHGVKF 282

Query: 239 IRGCVPQSIMKLE---NGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           IR  VP  I ++E    G+L V     DG    + ++TVL A GRD     +GL+  GVK
Sbjct: 283 IRQFVPTKIEQIEAGMPGRLKVTSQAPDGTETTDEYNTVLLAIGRDACTRNIGLEIPGVK 342

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N KTG+I V + EQT+ P +YAIGDVI D  ELTPVAIQAGRLLA+RLY + T   DY 
Sbjct: 343 INEKTGKIPVNDEEQTNVPYIYAIGDVIQDKLELTPVAIQAGRLLAKRLYGDSTLKSDYV 402

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYG CGLSEE +I ++GE+N+E+YH  F PLEW++ +      + CY K+
Sbjct: 403 NVPTTVFTPLEYGACGLSEENAIRQYGEENVEVYHSYFWPLEWTVPARDN---NKCYAKI 459

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+   ++ VVGFH L PNAGE+TQ   +A+K G T DQ+ N +GIHP  AEIFTTL VT
Sbjct: 460 ICNLKDNERVVGFHVLSPNAGEITQGFAVAIKCGLTKDQLDNTIGIHPVCAEIFTTLTVT 519

Query: 474 K 474
           K
Sbjct: 520 K 520


>gb|AAF15900.1|AF208018_1 thioredoxin reductase [Homo sapiens]
          Length = 497

 Score =  506 bits (1302), Expect = e-141
 Identities = 265/482 (54%), Positives = 341/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KE A+YGKKV VLD+  P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEPAQYGKKVMVLDFGTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|NP_001087660.1| thioredoxin reductase 3 [Xenopus laevis]
 gb|AAH81053.1| MGC81848 protein [Xenopus laevis]
          Length = 596

 Score =  505 bits (1300), Expect = e-141
 Identities = 259/483 (53%), Positives = 341/483 (70%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYDL+VIGGGSGGLACSKEAA +GKKV VLD+V P+  GTSWGLGGTCVNVGCIPKKL
Sbjct: 109 TYDYDLIVIGGGSGGLACSKEAASFGKKVMVLDFVVPTPQGTSWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++++G+++ KDS+ FGW   EQ   +W  M +++ +YI S+N+ Y+V LRDK+V+YE
Sbjct: 169 MHQAAILGQSL-KDSRKFGWEYEEQVKHNWETMREAIQNYIGSLNWGYRVALRDKQVRYE 227

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F+++H ++  + K      T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 228 NAYGEFVESHKIKATNKKGKESFFTAEKFVVATGERPRYLNIPGDKEYCITSDDLFSLPY 287

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G D  +MVRSI LRGFDQ+MA++ G +ME    ++F
Sbjct: 288 CPGKTLVVGASYVALECAGFLAGIGLDATVMVRSIFLRGFDQEMANRAGAYMETHG-VKF 346

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           I+  VP  +  LE G     ++  K T  D +  E+ ++TVL A GRD     +GL+K G
Sbjct: 347 IKQFVPIKVELLEEGTPGRIKVTAKSTQGD-QIIEDEYNTVLIAVGRDACTRNIGLEKIG 405

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N + G+I V + EQTS P+VYAIGD++D   ELTPVAIQAGRLLARRLY       D
Sbjct: 406 VKINERNGKIPVSDEEQTSVPHVYAIGDILDGKLELTPVAIQAGRLLARRLYRGSKVKCD 465

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCG +EE +IE +GE+NLE+YH  F PLEW++ S      ++C+ 
Sbjct: 466 YINVPTTVFTPLEYGCCGYAEEKAIEIYGEENLEVYHTLFWPLEWTVPSRDN---NTCFA 522

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K  +  V+GFH LGPNAGE+TQ  G AMK G T +++   +GIHPT AEIFTT++
Sbjct: 523 KIICNKQDNDRVIGFHVLGPNAGEITQGFGAAMKCGLTKEKLDETIGIHPTCAEIFTTMD 582

Query: 472 VTK 474
            +K
Sbjct: 583 TSK 585


>ref|XP_001365687.1| PREDICTED: similar to Thioredoxin reductase 1, cytoplasmic (TR)
           (TR1) [Monodelphis domestica]
          Length = 497

 Score =  504 bits (1299), Expect = e-141
 Identities = 266/481 (55%), Positives = 339/481 (70%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA+YGKK+ VLD+V P+ +G  WGLGGTCVNVGCIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAARYGKKILVLDFVTPTPLGNRWGLGGTCVNVGCIPKKLM 70

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW + E+   +W  M ++V +YI S+N+ Y+V LR+ +V YEN
Sbjct: 71  HQAALLGQAL-QDSRKYGWQLSEEVKHNWESMTEAVQNYIGSLNWGYRVALRENRVTYEN 129

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  T    +IA G RP+     G  +  ISSDD+F     
Sbjct: 130 AYGEFVGPHKIKATNNKGKEKFYTAERFLIATGERPRYPGIPGDKEYCISSDDLFSLSYC 189

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME +  I+FI
Sbjct: 190 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-DHGIKFI 248

Query: 240 RGCVPQSIMKLEN---GQLLVKWTTADG-EACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           +  VP  I +++    G L V   + DG E  E  ++TVL A GRD    K+GL+  GVK
Sbjct: 249 KKFVPIKIEQIKEGTPGTLRVVAQSTDGKETIEGEYNTVLLAIGRDSCTRKIGLETVGVK 308

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N KTG+I V + EQT+ P +YAIGDV+ D  ELTPVAIQAGRLLARRLY   T   DYD
Sbjct: 309 INEKTGKIPVNDEEQTNVPYIYAIGDVLEDKLELTPVAIQAGRLLARRLYAGSTIKCDYD 368

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY KV
Sbjct: 369 NVPTTVFTPLEYGACGLSEERAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAKV 425

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC    ++ VVGFH LGPNAGEVTQ    A+K G T +Q+ + +GIHP  AE+FTTL VT
Sbjct: 426 ICHVRDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKNQLDSTIGIHPVCAEVFTTLSVT 485

Query: 474 K 474
           K
Sbjct: 486 K 486


>emb|CBN80599.1| Thioredoxin reductase 3 [Dicentrarchus labrax]
          Length = 600

 Score =  503 bits (1295), Expect = e-140
 Identities = 270/483 (55%), Positives = 342/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAAMLGKKVMVLDYVVPTPKGTSWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G T  +D++ FGW   E    +W  M  +VN+YI S+N+ Y+V LRDK V Y N
Sbjct: 174 HQTALLG-TAMQDARKFGWEFEETVKHNWETMKTAVNNYIGSLNWGYRVALRDKNVNYVN 232

Query: 121 LLGSFIDAHTLELWHPKKGTKTV-TTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
               FI+ H ++  + K+G +T+ T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 233 AYAEFIEPHKIKATN-KRGKETLYTAAKFVLATGERPRYLGIPGDKEYCITSDDLFSLSY 291

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLV+GASYVALEC GF+ G+G DV +MVRSILLRGFDQDMA++ GE ME E  ++F
Sbjct: 292 CPGKTLVIGASYVALECGGFLAGLGLDVTVMVRSILLRGFDQDMANRAGEHME-EHGVKF 350

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  VP  + +LE G     ++  K T +D E  E  ++TVL A GRD    K+GLDKAG
Sbjct: 351 LRKYVPVKVEELEAGTPGRLKVTAKSTESD-EIIEGEYNTVLIAVGRDACTDKIGLDKAG 409

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+NPK G+I V + EQT+ P++YAIGD+++   ELTPVAIQAG+LLARRLY       D
Sbjct: 410 VKVNPKNGKIPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYGGSKLKCD 469

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYG CGLSEE + E +G++N+E+YH    PLE+++        + CY 
Sbjct: 470 YINVPTTVFTPLEYGACGLSEERATELYGQENIEVYHSLLWPLEFTVPGRDN---NRCYS 526

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K  +  V+GFHYLGPNAGEVTQ  G+AMK G T +Q+ N +GIHPT AEIFTTLE
Sbjct: 527 KIICNKLDNDRVIGFHYLGPNAGEVTQGFGVAMKCGATKEQLDNTIGIHPTCAEIFTTLE 586

Query: 472 VTK 474
           VTK
Sbjct: 587 VTK 589


>gb|AAF32362.1|AF220760_1 thioredoxin reductase 1 [Rattus norvegicus]
          Length = 498

 Score =  503 bits (1295), Expect = e-140
 Identities = 269/483 (55%), Positives = 344/483 (71%), Gaps = 16/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KVIC+   ++ VVGFH LGPNAGEVTQA+   +K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVICNLKDNERVVGFHVLGPNAGEVTQAL-QPLKCGLTKQQLDSTIGIHPVCAEIFTTLS 482

Query: 472 VTK 474
           VTK
Sbjct: 483 VTK 485


>sp|Q9MYY8|TRXR1_PIG RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
 gb|AAF78791.1|AF277894_1 redox enzyme thioredoxin reductase [Sus scrofa]
          Length = 499

 Score =  503 bits (1295), Expect = e-140
 Identities = 262/481 (54%), Positives = 339/481 (70%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA++ K+V VLD+V P+ +GT WGLGGTCVNV CIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVSCIPKKLM 70

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW V E    DW +M ++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 71  HQAALLGQAL-RDSRNYGWNVEETIKHDWERMTEAVQNHIGSLNWGYRVALREKKVTYEN 129

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 130 AYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC 189

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+FI
Sbjct: 190 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKFI 248

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GVK
Sbjct: 249 RQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVK 308

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY+
Sbjct: 309 INEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYE 368

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K+
Sbjct: 369 NVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAKI 425

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL VT
Sbjct: 426 ICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVT 485

Query: 474 K 474
           K
Sbjct: 486 K 486


>gb|AAD43039.1|AF108213_1 NADPH-dependent thioredoxin reductase [Rattus norvegicus]
          Length = 496

 Score =  503 bits (1295), Expect = e-140
 Identities = 269/483 (55%), Positives = 344/483 (71%), Gaps = 16/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KVIC+   ++ VVGFH LGPNAGEVTQA+   +K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVICNLKDNERVVGFHVLGPNAGEVTQAL-QPLKCGLTKQQLDSTIGIHPVCAEIFTTLS 482

Query: 472 VTK 474
           VTK
Sbjct: 483 VTK 485


>ref|NP_001116145.1| thioredoxin reductase 1, cytoplasmic [Canis lupus familiaris]
          Length = 655

 Score =  503 bits (1294), Expect = e-140
 Identities = 262/481 (54%), Positives = 339/481 (70%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA+Y KK+ VLD+V P+  GT WGLGGTCVNVGCIPKKLM
Sbjct: 167 YDYDLIIIGGGSGGLAAAKEAARYNKKIMVLDFVTPTPRGTRWGLGGTCVNVGCIPKKLM 226

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW+  E    DW +M ++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 227 HQAALLGQAL-QDSRNYGWSTEETVKHDWDKMTEAVQNHIGSLNWGYRVALREKKVTYEN 285

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 286 AYGQFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDREYCISSDDLFSLPYC 345

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  ++FI
Sbjct: 346 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGVKFI 404

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + ++E G      +V  +T+  E  E  ++TVL A GRD    K+GL+  GVK
Sbjct: 405 RQFVPIKVEQIEAGTPGRLRVVAQSTSSSETIEGEYNTVLLAIGRDACTRKIGLETVGVK 464

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY+
Sbjct: 465 INEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYAGSNVKCDYE 524

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY KV
Sbjct: 525 NVPTTVFTPLEYGACGLSEERAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAKV 581

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL VT
Sbjct: 582 ICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKMQLDSTIGIHPICAEVFTTLSVT 641

Query: 474 K 474
           K
Sbjct: 642 K 642


>sp|O89049|TRXR1_RAT RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=NADPH-dependent thioredoxin reductase;
           AltName: Full=Thioredoxin reductase TR1
          Length = 498

 Score =  502 bits (1293), Expect = e-140
 Identities = 269/483 (55%), Positives = 342/483 (70%), Gaps = 16/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW + +    DW +M +SV ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           IR  VP  I ++E G     ++  K T ++ E  E+ F+TVL A GRD     +GL+  G
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLKVTAKSTNSE-ETIEDEFNTVLLAVGRDSCTRTIGLETVG 306

Query: 294 VKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY   T   D
Sbjct: 307 VKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCD 366

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           YD V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY 
Sbjct: 367 YDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYA 423

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KVIC+   ++ VVGFH LGPNAGEVTQ    A K G T  Q+ + +GIHP  AEIFTTL 
Sbjct: 424 KVICNLKDNERVVGFHVLGPNAGEVTQGFA-AAKCGLTKQQLDSTIGIHPVCAEIFTTLS 482

Query: 472 VTK 474
           VTK
Sbjct: 483 VTK 485


>emb|CAH92925.2| thioredoxin reductase [Pongo abelii]
          Length = 499

 Score =  502 bits (1292), Expect = e-140
 Identities = 265/482 (54%), Positives = 341/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VLD+V P+ +GT WGL GTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLEGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 70  MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL+VGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 248 IRQFVPIKVGQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLE ++ S      + CY K
Sbjct: 368 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLERTIPSRDN---NKCYAK 424

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 425 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 484

Query: 473 TK 474
           TK
Sbjct: 485 TK 486


>ref|XP_002938124.1| PREDICTED: thioredoxin reductase 1, cytoplasmic-like [Xenopus
           (Silurana) tropicalis]
          Length = 651

 Score =  499 bits (1286), Expect = e-139
 Identities = 264/480 (55%), Positives = 333/480 (69%), Gaps = 12/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA SKEAA YGKKV VLD+V P+ +GT WGLGGTCVNVGCIPKKLM
Sbjct: 166 YDYDLIVIGGGSGGLAASKEAANYGKKVLVLDFVTPTPLGTKWGLGGTCVNVGCIPKKLM 225

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+ + + KDS+ +GW + +    +W  M  SV +YI S+NF Y+V L    VKYEN
Sbjct: 226 HQAALLRQAL-KDSQKYGWQIEDNIQHNWEIMTDSVLNYIGSLNFNYRVSLMQNNVKYEN 284

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ HT++  + +   K  T    +IA G RP+ L   G  +  I+SDD+F     
Sbjct: 285 GYGEFVEPHTIKSTNSRGKEKYFTAEKFLIATGERPRYLGIPGDKEYCITSDDLFSLPYC 344

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQ MA+ IGE+ME E  ++FI
Sbjct: 345 PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQQMANMIGEYME-EHGVKFI 403

Query: 240 RGCVPQSIMKLE---NGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           + CVP  I ++E    G+L V    +DG    E ++TVL A GRD     +GL+  GVK+
Sbjct: 404 KQCVPTKIEQIEAGTPGRLKVTSQASDGAETTEEYNTVLLAIGRDACTRNIGLEIPGVKI 463

Query: 297 NPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           N KTG+I V + EQT+ P +YAIGDV+ D  ELTPVAIQAGRLLARRLY + T   DY  
Sbjct: 464 NEKTGKIPVNDEEQTNVPYIYAIGDVLQDKLELTPVAIQAGRLLARRLYGDSTVKCDYVN 523

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EYG CGLSEE +I ++ E+N+E+YH  F PLEW++ +      + CY K+I
Sbjct: 524 VPTTVFTPLEYGACGLSEEHAIRQYEEENIEVYHSYFWPLEWTVPARDN---NKCYAKII 580

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           C+      VVGFH L PNAGE+TQ   +A+K G T DQ+ N +GIHP  AEIFTTL VTK
Sbjct: 581 CNLKDKGRVVGFHVLSPNAGEITQGFAVAIKCGLTKDQLDNTIGIHPVCAEIFTTLTVTK 640


>ref|NP_001116249.1| thioredoxin reductase 3 [Gallus gallus]
          Length = 606

 Score =  498 bits (1282), Expect = e-139
 Identities = 261/482 (54%), Positives = 338/482 (70%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+ +GTSWGLGGTCVNVGCIPKKL
Sbjct: 117 TYDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPLGTSWGLGGTCVNVGCIPKKL 176

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+A+GW   EQ   +W  M+++V +YI S+N+ Y++ LR+K V Y+
Sbjct: 177 MHQAALLGQAL-KDSRAYGWQYDEQVKHNWEIMVEAVQNYIGSLNWGYRLSLREKSVTYQ 235

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F++ H ++  + K      T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 236 NSYGEFVEPHKIKATNRKGQVTYHTAETFVLATGERPRYLGIPGDKEYCITSDDLFSLPY 295

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQ+MA+KIG  ME    + F
Sbjct: 296 CPGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEMAEKIGAHMETHG-VTF 354

Query: 239 IRGCVPQSIMKLEN---GQLLVKWTTADG-EACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + +LE+   G+L V   + +G E  E  ++TVL A GRD     +GL   GV
Sbjct: 355 IRKFVPTQVERLEDGTPGRLKVTAKSTEGPEFFEGEYNTVLIAIGRDACTRNIGLQTIGV 414

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G++ V + E+T+ P VYAIGD++D   ELTPVAIQAG+LLARRLY   +T  DY
Sbjct: 415 KINEKNGKVPVNDEERTNVPYVYAIGDILDGKLELTPVAIQAGKLLARRLYGGSSTKCDY 474

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYG CGL+EE +IE++G+ NLE+YH  F PLEW++        ++CY K
Sbjct: 475 INVPTTVFTPLEYGSCGLAEEKAIEEYGKQNLEVYHSLFWPLEWTVPGRDN---NTCYAK 531

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K     VVGFH LGPNAGEVTQ    A+K G T + +   +GIHPT AE+FTT+++
Sbjct: 532 IICNKLDGNRVVGFHVLGPNAGEVTQGFAAAIKCGLTKELLDETIGIHPTCAEVFTTMDI 591

Query: 473 TK 474
           TK
Sbjct: 592 TK 593


>gb|AAN06824.1| thioredoxin reductase [Sus scrofa]
          Length = 480

 Score =  498 bits (1282), Expect = e-139
 Identities = 258/476 (54%), Positives = 337/476 (70%), Gaps = 15/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA++ K+V VLD+V P+ +GT WGLGGTCVNVGCIPKKLM
Sbjct: 5   YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 64

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW V E    DW +M ++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 65  HQAALLGQAL-RDSRNYGWNVEETIKHDWERMTEAVQNHIGSLNWGYRVALREKKVTYEN 123

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 124 AYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC 183

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  ++FI
Sbjct: 184 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGVKFI 242

Query: 240 RGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           R  VP  + ++E G     ++  K T +D E  E  ++TVL A GRD     +GL+  GV
Sbjct: 243 RQFVPIKVEQIEAGMPGRLRVTAKATNSD-ETIEGEYNTVLLAIGRDACTRNIGLETVGV 301

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           ++N KTG+I V + EQT+ P VY IGD+++  PELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 302 EINEKTGKIPVTDEEQTNVPYVYTIGDILEGKPELTPVAIQAGRLLAQRLYGGSTVKCDY 361

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+EIYH  F PLEW++ S      + CY K
Sbjct: 362 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEIYHSYFWPLEWTIPSRDN---NKCYAK 418

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFT 468
           ++C+   ++ VVGFH LGPNAGEVTQ    A+K G T DQ+ + +GIHP  AE+FT
Sbjct: 419 IVCNIKDNERVVGFHILGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHPVCAEVFT 474


>gb|EFW43678.1| thioredoxin reductase 3 [Capsaspora owczarzaki ATCC 30864]
          Length = 500

 Score =  497 bits (1280), Expect = e-138
 Identities = 263/486 (54%), Positives = 342/486 (70%), Gaps = 19/486 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+V+GGGSGGLA SK+AAK GK+VCVLD+VKPS  G++WGLGGTCVNVGCIPKKLM
Sbjct: 10  YDYDLIVVGGGSGGLALSKQAAKLGKRVCVLDFVKPSPQGSTWGLGGTCVNVGCIPKKLM 69

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+ L+GE I +D++ FGW V +     DW++++  V+ +I  +NF Y+V LR+  V Y 
Sbjct: 70  HQACLLGEAI-EDAEKFGWEVEKANIKHDWSKLVMGVSDHIGGLNFAYRVSLRENNVTYL 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F DAHT+E    K+   T+T    V+AVGGRPK     G  +L I+SDD+F    
Sbjct: 129 NAYGVFKDAHTIECTDKKRKVTTLTAEHFVLAVGGRPKYPDIPGARELGITSDDMFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTLVVGASYVALECAGF+ G+GYD  +M RSI LRGFDQ  A++I  +M  E   +F
Sbjct: 189 APGKTLVVGASYVALECAGFLTGLGYDTTVMARSIFLRGFDQQCAEQIAAYMS-EHGTKF 247

Query: 239 IRGCVPQSIMKLE------NGQLLVKWTTADGEACE---EAFDTVLNATGRDPDVAKLGL 289
           +R CVP S+ ++E       G+  ++ T  DG A E   + FDTVL A GR+   + +GL
Sbjct: 248 LRRCVPLSLERIEPEADSATGRHRIRVTWEDGLANEPGSDVFDTVLFAIGREAVTSTIGL 307

Query: 290 DKAGVKLNPKTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETT 348
           +  G+K N  +G++    EQTS PNV+AIGDVI+  PELTPVAIQAGRLLA+RLY   TT
Sbjct: 308 EALGLKAN-ASGKVDAPLEQTSVPNVFAIGDVINGRPELTPVAIQAGRLLAKRLYGGATT 366

Query: 349 LMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASS 408
            MDY  + T VFTP+EYGC G++EE +I  + E+N+E++HQ F PLEW++  A RP AS+
Sbjct: 367 QMDYANIPTTVFTPLEYGCIGMAEEDAIALYKEENIEVFHQYFQPLEWTV--AHRP-AST 423

Query: 409 CYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFT 468
           CY K+IC+K  +  V+G H LGPNAGE+TQ  G+A +LG T D     VGIHPT +E FT
Sbjct: 424 CYCKLICNKLDNMRVIGLHILGPNAGEITQGYGVAFRLGATKDDFDMTVGIHPTCSENFT 483

Query: 469 TLEVTK 474
           TL++T+
Sbjct: 484 TLDITR 489


>ref|XP_002915522.1| PREDICTED: thioredoxin reductase 1, cytoplasmic-like [Ailuropoda
           melanoleuca]
          Length = 651

 Score =  497 bits (1280), Expect = e-138
 Identities = 259/482 (53%), Positives = 339/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+++GGGSGGLA +KEAAKY KK+ VLD+V P+  GT WGLGGTCVNVGCIPKKLM
Sbjct: 165 YDYDLIIVGGGSGGLAAAKEAAKYDKKIMVLDFVTPTPHGTRWGLGGTCVNVGCIPKKLM 224

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ +GW   E    DW +M ++V ++I S+N+ Y+V LR+KKV YEN
Sbjct: 225 HQAALLGQAL-RDSRNYGWDTEETVKHDWNKMTEAVQNHIGSLNWGYRVALREKKVTYEN 283

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F     
Sbjct: 284 AYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDREYCISSDDLFSLPYC 343

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  ++FI
Sbjct: 344 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGVKFI 402

Query: 240 RGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           +  VP  + ++E G     +++ K T++D E  E  ++TVL A GRD    K+GL+  GV
Sbjct: 403 KQFVPIKVEQIEAGTPGRLRVVAKSTSSD-ETIEGEYNTVLLAIGRDACTRKIGLETVGV 461

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY
Sbjct: 462 KINEKNGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYAGSNVKCDY 521

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++E FGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 522 ENVPTTVFTPLEYGACGLSEEKAVETFGEENIEVYHSFFWPLEWTIPSRDN---NKCYAK 578

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE+FTTL V
Sbjct: 579 IICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSV 638

Query: 473 TK 474
           TK
Sbjct: 639 TK 640


>ref|XP_002288115.1| thioredoxin reductase [Thalassiosira pseudonana CCMP1335]
 gb|EED95558.1| thioredoxin reductase [Thalassiosira pseudonana CCMP1335]
          Length = 503

 Score =  497 bits (1280), Expect = e-138
 Identities = 261/489 (53%), Positives = 335/489 (68%), Gaps = 24/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDL+V+GGGSGGLA SKEAA +G +V VLDYVKPS  G++WGLGGTCVNVGCIPKKLM
Sbjct: 12  YEYDLLVLGGGSGGLAASKEAAAHGARVAVLDYVKPSPAGSTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGETIHKDSKAFGWTVGE-QTFDWAQMLK--------------SVNSYIKSINFK 106
           H ++L+      D   +G  V E QT +W  M +              +V ++I+ +NFK
Sbjct: 72  HTAALLNYQQKVDQPHYGINVSESQTEEWMGMSQDNADAPHSWGILKNNVQNHIRGLNFK 131

Query: 107 YKVELRDKKVKYENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGGDL 166
           Y+V+LR+K+V Y N+LG F DAHT+E    K    ++T    +IAVGGRP PL CEGG+L
Sbjct: 132 YRVDLREKEVTYLNMLGKFKDAHTVETVDKKGNVGSITASRFLIAVGGRPSPLDCEGGEL 191

Query: 167 AISSDDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKI 226
           AISSDD+F  +  PGK L VGASY++LECAGF+KG+G DV + VRSILLRGFD++ AD I
Sbjct: 192 AISSDDVFSLENDPGKVLCVGASYISLECAGFLKGIGKDVTVAVRSILLRGFDRECADLI 251

Query: 227 GEFMEVESKIEFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAK 286
           GE M  E  I F    VP+ ++K E G++ V ++  D     E +DTVL A GR  D +K
Sbjct: 252 GEHMRHEG-IVFKEEVVPKKLVKTEGGRIAVTFSNGD----VEEYDTVLAAIGRTGDTSK 306

Query: 287 LGLDKAGVKLNPKTGRIWVENEQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNN 345
           LGL+  G+ +NPK  +I  + EQT TPN+Y IGDV+D  PELTPVAI AG++L+RRL+  
Sbjct: 307 LGLENVGIDVNPKNAKIPAKLEQTCTPNIYVIGDVMDGCPELTPVAIHAGKMLSRRLFAG 366

Query: 346 ETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPA 405
            T  MDY  VCT VFTP+EYG  G SE+ +I +FG++N+E+YH+ F PLEWSLS +   +
Sbjct: 367 STAPMDYRNVCTTVFTPLEYGTVGYSEDDAIAEFGKENVEVYHKYFIPLEWSLSPSRSES 426

Query: 406 ASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
              C  K I  K+  K V+G HYLGPNAGEV Q  G AMKLG  ++ +   VGIHPTTAE
Sbjct: 427 QGFC--KAIVYKATRK-VLGLHYLGPNAGEVMQGFGTAMKLGCKFEDITETVGIHPTTAE 483

Query: 466 IFTTLEVTK 474
             TTL +TK
Sbjct: 484 ELTTLSITK 492


>dbj|BAC87474.1| unnamed protein product [Homo sapiens]
          Length = 581

 Score =  495 bits (1275), Expect = e-138
 Identities = 260/476 (54%), Positives = 336/476 (70%), Gaps = 13/476 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA+YGKKV VL +V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 109 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLVFVTPTPLGTRWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + +DS+ +GW V E    DW +M+++V ++I S+N+ Y+V LR+KKV YE
Sbjct: 169 MHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYE 227

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 228 NAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 287

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 288 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 346

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  + ++E G      +V  +T   E  E  ++TV+ A GRD    K+GL+  GV
Sbjct: 347 IRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGV 406

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD++ D  ELTPVAIQAGRLLA+RLY   T   DY
Sbjct: 407 KINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDY 466

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           + V T VFTP+EYG CGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 467 ENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAK 523

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFT 468
           +IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE F+
Sbjct: 524 IICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEFFS 579


>ref|NP_001116163.1| thioredoxin reductase 2, mitochondrial [Gallus gallus]
          Length = 518

 Score =  494 bits (1271), Expect = e-137
 Identities = 253/484 (52%), Positives = 349/484 (72%), Gaps = 19/484 (3%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           +YDL+VIGGGSGGLAC+KEAA++GK V VLDYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 29  EYDLLVIGGGSGGLACAKEAAQFGKNVAVLDYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 88

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  + KD++ +GW+V      +W+ M ++V +Y+KS+N+ ++V+L+DKKVKY N+
Sbjct: 89  QAALLGGAL-KDAQHYGWSVAHPVHHNWSVMAQAVQNYVKSLNWGHRVQLQDKKVKYFNM 147

Query: 122 LGSFIDAHTLELWHPKKGTK--TVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
            GSF D+HT  +    KG K  T+T   +VIA GGRPK P    G  +  I+SDD+FW K
Sbjct: 148 KGSFSDSHT--VCGIAKGGKETTLTAEKIVIATGGRPKYPTHITGALEYGITSDDLFWLK 205

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYD----VKIMVRSILLRGFDQDMADKIGEFMEVE 233
           ++PGKTLVVGASYV+LECAGF+ G+G D    ++I++RSI LRGFDQ MA  + E ME  
Sbjct: 206 DSPGKTLVVGASYVSLECAGFLTGIGLDTTVIMRIIMRSIPLRGFDQQMASLVTEHME-S 264

Query: 234 SKIEFIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKA 292
              +F++ CVP  + KLE+ +L V W   + G    ++FDTV+ A GR PD+  L LD  
Sbjct: 265 YGTKFLKKCVPAKVEKLESSRLQVTWKNTELGTEETDSFDTVMWAVGRVPDIKTLNLDSV 324

Query: 293 GVKLNPKTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLM 350
           GVK N +TG+I V+ +E TS P++YAIGD+ +  PELTP AI AG+LLARRL+ + + LM
Sbjct: 325 GVKTNSETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLARRLFGHSSELM 384

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DYD V T VFTP+EYGC GLSEE +++ +G DN+E++H  + PLE++++      A+ CY
Sbjct: 385 DYDNVPTTVFTPLEYGCVGLSEEKAVQCYGSDNVEVFHAYYKPLEFTVAERD---AAQCY 441

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
           +K++C + R++ ++G H++GPNAGEV Q   L +K G TY Q++  +GIHPT AE  T L
Sbjct: 442 IKMVCLREREQRILGLHFIGPNAGEVIQGFALGIKCGATYPQLMKTIGIHPTCAEEITKL 501

Query: 471 EVTK 474
            +TK
Sbjct: 502 HITK 505


>ref|XP_516719.2| PREDICTED: thioredoxin reductase 3 [Pan troglodytes]
          Length = 752

 Score =  494 bits (1271), Expect = e-137
 Identities = 259/483 (53%), Positives = 341/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 266 YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 325

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 326 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVN 384

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 385 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 443

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 444 CPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 502

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 503 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 561

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLARRL+       D
Sbjct: 562 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLARRLFGASLEKCD 621

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLEIYH  F PLEW+++       ++CY 
Sbjct: 622 YINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN---NTCYA 678

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 679 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 738

Query: 472 VTK 474
           +TK
Sbjct: 739 ITK 741


>gb|AAH30028.1| TXNRD3 protein [Homo sapiens]
          Length = 678

 Score =  493 bits (1270), Expect = e-137
 Identities = 258/483 (53%), Positives = 342/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 192 YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 251

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M+K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 252 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMIKAIQNHISSLNWGYRLSLREKAVAYVN 310

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 311 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 369

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 370 CPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 428

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 429 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 487

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLA+RL+       D
Sbjct: 488 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCD 547

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLEIYH  F PLEW+++       ++CY 
Sbjct: 548 YINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN---NTCYA 604

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 605 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 664

Query: 472 VTK 474
           +TK
Sbjct: 665 ITK 667


>emb|CBK24910.2| unnamed protein product [Blastocystis hominis]
 emb|CBK23629.2| unnamed protein product [Blastocystis hominis]
          Length = 497

 Score =  493 bits (1268), Expect = e-137
 Identities = 257/479 (53%), Positives = 330/479 (68%), Gaps = 12/479 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYDL+VIGGGSGGLA SKEAA  G  V + DYVKPS  G++WGLGGTCVNVGCIPKKL
Sbjct: 15  TYDYDLIVIGGGSGGLAASKEAADLGATVALFDYVKPSPQGSTWGLGGTCVNVGCIPKKL 74

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MHQ+++IGE + +D+ +FGW V E    W  ++ +V  YI+ +N+ Y+V L  K V Y N
Sbjct: 75  MHQAAIIGEFV-RDASSFGWDVPEVHHHWNTLVDNVQDYIRGLNYNYRVSLMSKHVTYYN 133

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGGDLAISSDDIFWRKEAP 180
            L    DAHT+E           T R +++AVGGRP  L C G +LA++SDD+F     P
Sbjct: 134 QLAYVKDAHTVEGTDVFGDKHIYTCRRIIVAVGGRPNKLGCPGEELAVTSDDLFMLDHPP 193

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
            KTL+VGAS++ALECAGF+  +G+DV +MVRSILLRGFDQ+ A+KIG+FM+ E  I F+ 
Sbjct: 194 KKTLLVGASFIALECAGFLHHLGFDVTVMVRSILLRGFDQECANKIGDFMK-EEGIHFLH 252

Query: 241 GCVPQSIMKLENGQLLVKWT---TADGE-ACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
             VP  + +L NG++LVK+     A+ E   EE FDTV++  GR  D  +LGLD+ GVK 
Sbjct: 253 NTVPTELQRLPNGRILVKYQGSGFANSELRGEEEFDTVVSCIGRYADTERLGLDQLGVK- 311

Query: 297 NPKTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
             + G+I    EQTS PN+Y IGDV+    ELTPVAIQ G+LLARRLY   +  MDY+ V
Sbjct: 312 -TRRGKILSVQEQTSVPNIYGIGDVLYGKQELTPVAIQTGKLLARRLYGGSSVQMDYENV 370

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
              VFTP+EYG CGL+EEA++E+FGEDN+E+Y   FTPLEW +S   R     C+ K+I 
Sbjct: 371 PMTVFTPLEYGNCGLTEEAALERFGEDNVEVYVSQFTPLEWQISPHRRKEV--CFAKLI- 427

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            K  D  ++GFH L PNAGE+TQ  GLA +   TY  ++++VGIHPT AE FTTL VTK
Sbjct: 428 TKRDDGLILGFHILSPNAGEITQGFGLAFQTKATYQNLMDLVGIHPTIAEEFTTLSVTK 486


>sp|Q86VQ6|TRXR3_HUMAN RecName: Full=Thioredoxin reductase 3; AltName: Full=Thioredoxin
           and glutathione reductase; AltName: Full=Thioredoxin
           reductase TR2
          Length = 682

 Score =  492 bits (1267), Expect = e-137
 Identities = 258/483 (53%), Positives = 341/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 194 YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 253

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 254 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVN 312

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 313 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 371

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 372 CPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 430

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 431 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 489

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLA+RL+       D
Sbjct: 490 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCD 549

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLEIYH  F PLEW+++       ++CY 
Sbjct: 550 YINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN---NTCYA 606

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 607 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 666

Query: 472 VTK 474
           +TK
Sbjct: 667 ITK 669


>ref|NP_443115.1| thioredoxin reductase 3 isoform 1 [Homo sapiens]
          Length = 643

 Score =  492 bits (1267), Expect = e-137
 Identities = 258/483 (53%), Positives = 341/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 155 YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 214

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 215 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVN 273

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 274 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 332

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 333 CPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 391

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 392 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 450

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLA+RL+       D
Sbjct: 451 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCD 510

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLEIYH  F PLEW+++       ++CY 
Sbjct: 511 YINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN---NTCYA 567

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 568 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 627

Query: 472 VTK 474
           +TK
Sbjct: 628 ITK 630


>gb|AAH50032.1| TXNRD3 protein [Homo sapiens]
          Length = 681

 Score =  492 bits (1267), Expect = e-137
 Identities = 258/483 (53%), Positives = 341/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 195 YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 254

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 255 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVN 313

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 314 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 372

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 373 CPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 431

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 432 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 490

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLA+RL+       D
Sbjct: 491 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCD 550

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLEIYH  F PLEW+++       ++CY 
Sbjct: 551 YINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN---NTCYA 607

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 608 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 667

Query: 472 VTK 474
           +TK
Sbjct: 668 ITK 670


>gb|AAD51325.1|AF171055_1 thioredoxin reductase TR2 [Homo sapiens]
          Length = 579

 Score =  492 bits (1267), Expect = e-137
 Identities = 258/483 (53%), Positives = 341/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 91  YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 150

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 151 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVN 209

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 210 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 268

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 269 CPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 327

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 328 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 386

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLA+RL+       D
Sbjct: 387 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCD 446

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLEIYH  F PLEW+++       ++CY 
Sbjct: 447 YINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN---NTCYA 503

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 504 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 563

Query: 472 VTK 474
           +TK
Sbjct: 564 ITK 566


>ref|NP_001080052.1| thioredoxin reductase 2 [Xenopus laevis]
          Length = 504

 Score =  492 bits (1266), Expect = e-137
 Identities = 253/480 (52%), Positives = 342/480 (71%), Gaps = 13/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL+VIGGGSGGLAC+K+AA++GKKV V DYV+PS  GT WG+GGTCVNVGCIPKKLM
Sbjct: 18  HDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLM 77

Query: 62  HQSSLIGETIHKDSKAFGW-TVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++LIG T+ KD+  +GW T  E   DW +M  +V +Y+KS+N+ ++++L+DKKVKY N
Sbjct: 78  HQAALIGSTM-KDAPHYGWGTPYEIQHDWGKMAGAVQNYVKSLNWGHRIQLQDKKVKYFN 136

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           L  +F+D H +     K G +T VT +++VIA GGRPK P    G  +  I+SDD+FW K
Sbjct: 137 LKANFVDEHCIR-GVTKAGKETLVTAQNIVIATGGRPKYPTHVPGALEYGITSDDLFWLK 195

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           E+PGKTLVVGASYV+LECAGF+ G+G +   MVRSI LRGFDQ MA  + ++ME     +
Sbjct: 196 ESPGKTLVVGASYVSLECAGFLTGIGLNTTAMVRSIPLRGFDQQMAYLVADYMESHG-TK 254

Query: 238 FIRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+  C P  + KL+NG+L V W  T  G+   + +DTV+ A GR  +   L L+K GVK+
Sbjct: 255 FLWKCTPSHVEKLKNGKLQVTWKNTQSGKEGVDIYDTVMWAVGRAAETQYLNLEKVGVKI 314

Query: 297 NPKTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDK 354
            P+TG+I V+ +E TS P++YAIGD+ +  PELTP AI AG+LLA RL++    LMDYD 
Sbjct: 315 KPETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLAIRLFSGSAELMDYDS 374

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EYGC G+SEE + E++G+DN+E++H  + PLE++++      AS CY+K+I
Sbjct: 375 VPTTVFTPLEYGCVGISEEEAKERYGDDNIEVFHAFYKPLEFTVAERD---ASQCYIKII 431

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           C +  D+ ++G H  GPNAGEV Q   L +K G TY Q++  VGIHPT AE  T L +TK
Sbjct: 432 CLRKHDQRILGLHLTGPNAGEVIQGFALGIKCGATYPQLMCTVGIHPTCAEEVTKLHITK 491


>ref|XP_001377333.1| PREDICTED: similar to TXNRD3 protein [Monodelphis domestica]
          Length = 721

 Score =  492 bits (1266), Expect = e-137
 Identities = 255/482 (52%), Positives = 333/482 (69%), Gaps = 13/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TY+YDL+VIGGGSGGLACSKEAA +GKKV VLDYV P+ +G SWGLGGTCVNVGCIPKKL
Sbjct: 234 TYEYDLIVIGGGSGGLACSKEAANWGKKVMVLDYVTPTPLGKSWGLGGTCVNVGCIPKKL 293

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ FGW   E    +W  M +++ +YI S+N+ Y+V LR+K V Y 
Sbjct: 294 MHQAALLGQAL-KDSRKFGWEYEENVKHNWETMTEAIQNYIGSLNWGYRVSLREKSVSYI 352

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G F++ HT++  + K      T    VIA G RP+ L   G  +  I+SDD+F    
Sbjct: 353 NSYGEFVEHHTIKAINRKGQETFYTAERFVIATGERPRYLGIPGDKEYCITSDDLFSLPY 412

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL++GASYVALEC GF+ G+G DV IMVRSILLRGFDQ++A+KIG +ME+   + F
Sbjct: 413 CPGKTLIIGASYVALECGGFLAGIGLDVTIMVRSILLRGFDQEIAEKIGSYMEMHG-VTF 471

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           +R  +P +I +LE G      +V  +T   E  E  ++TVL A GR+    K+GL+K GV
Sbjct: 472 LRQYIPVTIQQLEEGTPGRLKVVAKSTEGSETIEGEYNTVLIAIGRESCTRKIGLEKIGV 531

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N  TG+I V + EQT+   VYA+GDV+ D  ELTPVAIQAG+LLARRLY  +    DY
Sbjct: 532 KINENTGKIPVNDEEQTNVSYVYAVGDVLEDKLELTPVAIQAGKLLARRLYGGQLEKCDY 591

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYGCCG SEE + E F +DN+E++H  F PLEW+++        +C+ K
Sbjct: 592 INVPTTVFTPLEYGCCGFSEEKARELFNKDNIEVFHTYFWPLEWTIAGREN---DTCFGK 648

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  +  V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE+
Sbjct: 649 IICNKRDNNRVIGFHVLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEI 708

Query: 473 TK 474
           TK
Sbjct: 709 TK 710


>gb|AAH56136.1| Txnrd2 protein [Xenopus laevis]
          Length = 502

 Score =  492 bits (1266), Expect = e-137
 Identities = 253/480 (52%), Positives = 342/480 (71%), Gaps = 13/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL+VIGGGSGGLAC+K+AA++GKKV V DYV+PS  GT WG+GGTCVNVGCIPKKLM
Sbjct: 18  HDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLM 77

Query: 62  HQSSLIGETIHKDSKAFGW-TVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++LIG T+ KD+  +GW T  E   DW +M  +V +Y+KS+N+ ++++L+DKKVKY N
Sbjct: 78  HQAALIGSTM-KDAPHYGWGTPYEIQHDWGKMAGAVQNYVKSLNWGHRIQLQDKKVKYFN 136

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           L  +F+D H +     K G +T VT +++VIA GGRPK P    G  +  I+SDD+FW K
Sbjct: 137 LKANFVDEHCIR-GVTKAGKETLVTAQNIVIATGGRPKYPTHVPGALEYGITSDDLFWLK 195

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           E+PGKTLVVGASYV+LECAGF+ G+G +   MVRSI LRGFDQ MA  + ++ME     +
Sbjct: 196 ESPGKTLVVGASYVSLECAGFLTGIGLNTTAMVRSIPLRGFDQQMAYLVADYMESHG-TK 254

Query: 238 FIRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+  C P  + KL+NG+L V W  T  G+   + +DTV+ A GR  +   L L+K GVK+
Sbjct: 255 FLWKCTPSHVEKLKNGKLQVTWKNTQSGKEGVDIYDTVMWAVGRAAETQYLNLEKVGVKI 314

Query: 297 NPKTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDK 354
            P+TG+I V+ +E TS P++YAIGD+ +  PELTP AI AG+LLA RL++    LMDYD 
Sbjct: 315 KPETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLAIRLFSGSAELMDYDS 374

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EYGC G+SEE + E++G+DN+E++H  + PLE++++      AS CY+K+I
Sbjct: 375 VPTTVFTPLEYGCVGISEEEAKERYGDDNIEVFHAFYKPLEFTVAERD---ASQCYIKII 431

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           C +  D+ ++G H  GPNAGEV Q   L +K G TY Q++  VGIHPT AE  T L +TK
Sbjct: 432 CLRKHDQRILGLHLTGPNAGEVIQGFALGIKCGATYPQLMCTVGIHPTCAEEVTKLHITK 491


>ref|NP_001120487.1| thioredoxin reductase 2 [Xenopus (Silurana) tropicalis]
 gb|AAI61360.1| LOC100145605 protein [Xenopus (Silurana) tropicalis]
          Length = 502

 Score =  491 bits (1265), Expect = e-137
 Identities = 251/480 (52%), Positives = 341/480 (71%), Gaps = 13/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL+VIGGGSGGLAC+K+AA++GKKV V DYV+PS  GT WG+GGTCVNVGCIPKKLM
Sbjct: 18  HDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLM 77

Query: 62  HQSSLIGETIHKDSKAFGW-TVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++LIG T+ KD+  +GW T  E   +W +M K+V +Y+KS+N+ ++++L+DKKVKY N
Sbjct: 78  HQAALIGSTL-KDAPHYGWDTPNEIQHNWGKMAKAVQNYVKSLNWGHRIQLQDKKVKYFN 136

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           +  SF+D H +     K G +T VT  ++VIA GGRPK P    G  +  I+SDD+FW K
Sbjct: 137 MKASFVDEHCIR-GVTKAGKETLVTAENIVIATGGRPKYPTHVPGALEYGITSDDLFWLK 195

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           E+PGKTLVVGASYV+LECAGF+ G+G D   MVRSI LRGFDQ MA  + ++ME+    +
Sbjct: 196 ESPGKTLVVGASYVSLECAGFLTGIGLDTAAMVRSIPLRGFDQQMAYLVTDYMELHG-TK 254

Query: 238 FIRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+  C P ++ KL+NG+L V W  T  G+   + +DTV+ A GR  +   L L+K GV +
Sbjct: 255 FLWKCTPSNVEKLKNGKLEVTWKNTESGKEGADIYDTVMWAVGRAAETQYLNLEKVGVDV 314

Query: 297 NPKTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDK 354
              TG+I V  +E TS P++YAIGD+ +  PELTP AI AG+LLA RL++    LMDYD 
Sbjct: 315 KSDTGKIIVNASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLASRLFSGSAELMDYDS 374

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EYGC G+SEE + E++G+DN+E++H  + PLE+ ++       S CY+K+I
Sbjct: 375 VPTTVFTPLEYGCVGISEEDAKERYGDDNIEVFHAFYKPLEFIVAERN---GSQCYIKII 431

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           C +++D+ ++G H+ GPNAGEV Q   L +K G TY Q++  VGIHPT AE  T L +TK
Sbjct: 432 CLRTQDQRILGLHFTGPNAGEVIQGFALGIKCGATYHQLMRTVGIHPTCAEEVTKLHITK 491


>emb|CBY19735.1| unnamed protein product [Oikopleura dioica]
          Length = 596

 Score =  491 bits (1264), Expect = e-136
 Identities = 263/478 (55%), Positives = 329/478 (68%), Gaps = 12/478 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLA SKEAAK GKKV VLD+VKPS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 115 YDYDLVVIGGGSGGLAASKEAAKLGKKVAVLDFVKPSPAGTQWGLGGTCVNVGCIPKKLM 174

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ--TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQS+L+GE IH D+K +GW V  +  +  W +M  +V  YI SIN+ YKVELRD  VKY 
Sbjct: 175 HQSALLGEAIH-DAKKYGWNVEPEKISHSWEKMQMAVGDYIGSINWGYKVELRDNNVKYL 233

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGGDLAISSDDIFWRKEA 179
           N  G   D HT+   + +  T+ +TT+++++A G RP+     G + AISSDD+FW  E 
Sbjct: 234 NSYGEIKDRHTVVCTNKRGKTEELTTQNILVATGERPRLPDIPGIEHAISSDDLFWLPEC 293

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+KG+G DV I VRSI LRGFDQ  AD +G  +E E+  + I
Sbjct: 294 PGKTLVVGASYVALECAGFLKGLGLDVDICVRSIFLRGFDQQCADIVGNHLEKEAGCKMI 353

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           R   P SI KLENG L V    ++G    + + TVL A GRDP  + +GL+   V+L  +
Sbjct: 354 RPATPTSIEKLENGMLKVH--ISNGTTVVDEYKTVLMAIGRDPCTSGIGLENVKVEL-AE 410

Query: 300 TGRIWV-ENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           +G++ V + E+T+  NV+AIGD++ D  ELTPVAIQAGRLLARR+Y      M Y+ V T
Sbjct: 411 SGKVIVNDGEETNIENVFAIGDILKDRLELTPVAIQAGRLLARRMYAGAVEKMSYNTVAT 470

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EY  CGLSEE +IEK+G DN+E+YH+ F PLEW++       A+ CY+K I  +
Sbjct: 471 TVFTPLEYSACGLSEEKAIEKYGLDNIEVYHRKFWPLEWTVPGKD---ANLCYMKAITIR 527

Query: 418 SR-DKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              ++ V+G HY+GPNAGEV Q    AMK G T   +   VGIHP  AE FT L +TK
Sbjct: 528 HEPNEPVIGLHYVGPNAGEVMQGFSAAMKSGLTKTILDGTVGIHPVNAEWFTDLSITK 585


>ref|NP_001116250.1| thioredoxin reductase 3 [Canis lupus familiaris]
          Length = 586

 Score =  491 bits (1263), Expect = e-136
 Identities = 254/481 (52%), Positives = 337/481 (70%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 98  YDYDLIVIGGGSGGLACAQEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 157

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +D++ FGW   +Q    W  M +++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 158 HQAALLGQAL-RDARKFGWEYSQQVKHTWETMTEAIQNHIGSLNWGYRLSLREKAVAYVN 216

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ H ++  + K      T    V+A G RP+ L  +G  +  I+SDD+F     
Sbjct: 217 SYGEFVEHHKIKATNRKGQETCYTAAKFVLATGQRPRYLGIQGDKEYCITSDDLFSLPYC 276

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV IMVRSILLRGFDQ+MA+K+G +ME +  ++F+
Sbjct: 277 PGKTLVVGASYVALECAGFLAGIGLDVTIMVRSILLRGFDQEMAEKVGSYME-QHGVKFL 335

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + +LE G      +V  +T   E  EE ++TVL A GRD    K+GL+K GVK
Sbjct: 336 RKFVPVLVQQLEKGSPGKLKVVAKSTEGPETIEEIYNTVLLAIGRDSCTRKIGLEKIGVK 395

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N K+G+I V + EQT+ P VYA+GD+++   ELTPVAIQAG+LLARRL+       DY 
Sbjct: 396 INEKSGKIPVNDVEQTNVPYVYAVGDILEGKLELTPVAIQAGKLLARRLFAGRLEKCDYV 455

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY K+
Sbjct: 456 NVPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---NTCYAKI 512

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  +  V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE+T
Sbjct: 513 ICNKLDNYRVIGFHVLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEIT 572

Query: 474 K 474
           K
Sbjct: 573 K 573


>ref|XP_001492801.1| PREDICTED: similar to thioredoxin reductase 3 [Equus caballus]
          Length = 565

 Score =  490 bits (1261), Expect = e-136
 Identities = 257/481 (53%), Positives = 336/481 (69%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 79  YDYDLIVIGGGSGGLACAQEAAVLGKKVMVLDFVLPSPQGTSWGLGGTCVNVGCIPKKLM 138

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M +++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 139 HQAALLGQAL-IDSRKFGWEYNQQVKHNWETMTEAIQNHIGSLNWGYRLSLREKAVAYVN 197

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ H ++  + K      T    VIA G RP+ L  +G  +  I+SDD+F     
Sbjct: 198 SYGEFVEHHKIKATNRKGQETCYTAAKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYC 257

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F+
Sbjct: 258 PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKFL 316

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  I +LE G      +V  +T    A E  ++TVL A GRD    K+GL+K GVK
Sbjct: 317 RKFVPVMIQQLEKGSPGKLRVVAESTEGPGAVEGVYNTVLLAIGRDSCTRKIGLEKIGVK 376

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N K+G+I V + EQT+ P VYAIGD+++   ELTPVAIQAG+LLARRL+       DY 
Sbjct: 377 INEKSGKIPVNDVEQTNVPYVYAIGDILEGKLELTPVAIQAGKLLARRLFGGRLEKCDYI 436

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYGCCGLSEE +IE   ++NLE+YH  F PLEW+++       ++CY K+
Sbjct: 437 NVPTTVFTPLEYGCCGLSEEKAIEVHKKENLEVYHTLFWPLEWTVAGRDN---NTCYAKI 493

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  ++ VVGFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE+T
Sbjct: 494 ICNKFDNERVVGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEIT 553

Query: 474 K 474
           K
Sbjct: 554 K 554


>gb|AAD39929.1|AF133519_1 thioredoxin reductase 3 [Homo sapiens]
          Length = 577

 Score =  490 bits (1261), Expect = e-136
 Identities = 257/483 (53%), Positives = 340/483 (70%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 89  YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 148

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 149 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVN 207

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 208 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 266

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGK LVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 267 CPGKPLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 325

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 326 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 384

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLA+RL+       D
Sbjct: 385 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCD 444

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLEIYH  F PLEW+++       ++CY 
Sbjct: 445 YINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN---NTCYA 501

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 502 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 561

Query: 472 VTK 474
           +TK
Sbjct: 562 ITK 564


>ref|XP_002923145.1| PREDICTED: thioredoxin reductase 3-like [Ailuropoda melanoleuca]
          Length = 656

 Score =  489 bits (1260), Expect = e-136
 Identities = 251/481 (52%), Positives = 337/481 (70%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PS  GTSWGLGGTCVNVGC+PKKLM
Sbjct: 170 YDYDLIVIGGGSGGLACAQEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCVPKKLM 229

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  D++ FGW   +Q   +W  M +++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 230 HQAALLGQAL-SDARKFGWEYHQQVKHNWETMTEAIQNHIGSLNWGYRLSLREKAVAYVN 288

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ H ++  + K      T    V+A G RP+ L   G  +  I+SDD+F     
Sbjct: 289 SYGEFVEHHKIKATNRKGQETYYTAAKFVLATGERPRYLGIRGDKEYCITSDDLFSLPYC 348

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F+
Sbjct: 349 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKFL 407

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  +P  + +LE G      +V  +T   E  EE ++TVL A GRD    K+GL+K GVK
Sbjct: 408 RKFIPVLVQQLEKGSPGKLKVVAKSTEGPETIEEIYNTVLLAIGRDSCTRKIGLEKIGVK 467

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N K+G+I V + EQT+ P VYA+GD+++   ELTPVAIQAG+LLARRL+       DY 
Sbjct: 468 INEKSGKIPVNDMEQTNVPYVYAVGDILEGKLELTPVAIQAGKLLARRLFAGRLEKCDYV 527

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY K+
Sbjct: 528 NVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEVYHTLFWPLEWTVAGRDN---NTCYAKI 584

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  +  V+GFH LGPNAGE+TQ    AMK G T  Q+ + +GIHPT  E+FTTLE+T
Sbjct: 585 ICNKFDNYRVIGFHVLGPNAGEITQGFAAAMKCGLTKQQLDDTIGIHPTCGEVFTTLEIT 644

Query: 474 K 474
           K
Sbjct: 645 K 645


>gb|EFB23450.1| hypothetical protein PANDA_012236 [Ailuropoda melanoleuca]
          Length = 540

 Score =  489 bits (1260), Expect = e-136
 Identities = 251/481 (52%), Positives = 337/481 (70%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PS  GTSWGLGGTCVNVGC+PKKLM
Sbjct: 54  YDYDLIVIGGGSGGLACAQEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCVPKKLM 113

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  D++ FGW   +Q   +W  M +++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 114 HQAALLGQAL-SDARKFGWEYHQQVKHNWETMTEAIQNHIGSLNWGYRLSLREKAVAYVN 172

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ H ++  + K      T    V+A G RP+ L   G  +  I+SDD+F     
Sbjct: 173 SYGEFVEHHKIKATNRKGQETYYTAAKFVLATGERPRYLGIRGDKEYCITSDDLFSLPYC 232

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F+
Sbjct: 233 PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKFL 291

Query: 240 RGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  +P  + +LE G      +V  +T   E  EE ++TVL A GRD    K+GL+K GVK
Sbjct: 292 RKFIPVLVQQLEKGSPGKLKVVAKSTEGPETIEEIYNTVLLAIGRDSCTRKIGLEKIGVK 351

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N K+G+I V + EQT+ P VYA+GD+++   ELTPVAIQAG+LLARRL+       DY 
Sbjct: 352 INEKSGKIPVNDMEQTNVPYVYAVGDILEGKLELTPVAIQAGKLLARRLFAGRLEKCDYV 411

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY K+
Sbjct: 412 NVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEVYHTLFWPLEWTVAGRDN---NTCYAKI 468

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  +  V+GFH LGPNAGE+TQ    AMK G T  Q+ + +GIHPT  E+FTTLE+T
Sbjct: 469 ICNKFDNYRVIGFHVLGPNAGEITQGFAAAMKCGLTKQQLDDTIGIHPTCGEVFTTLEIT 528

Query: 474 K 474
           K
Sbjct: 529 K 529


>ref|XP_002108982.1| hypothetical protein TRIADDRAFT_19325 [Trichoplax adhaerens]
 gb|EDV29780.1| hypothetical protein TRIADDRAFT_19325 [Trichoplax adhaerens]
          Length = 489

 Score =  487 bits (1253), Expect = e-135
 Identities = 254/481 (52%), Positives = 338/481 (70%), Gaps = 15/481 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+V+GGGSGGLACSKEAA+ G  V +LD+VKP+ +G SWGLGGTCVNVGCIPKKLM
Sbjct: 5   YSYDLIVVGGGSGGLACSKEAAEQGLTVALLDFVKPTPLGCSWGLGGTCVNVGCIPKKLM 64

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ+SL+GE+IH D+  +GW + E  +  W +M  +V ++I SINF Y+V+LRD+KVKY N
Sbjct: 65  HQASLLGESIH-DASHYGWEINENCSHSWEKMKDNVQNHIGSINFGYRVQLRDRKVKYLN 123

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G+ +D HT++    +     +T ++ VI+ G RP+     G  +  ++SDD+F  ++ 
Sbjct: 124 AYGTLVDPHTIKAVDRRGKETLLTAKNFVISSGCRPRYPDIPGAKEHCVTSDDLFSLEKC 183

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLV+GASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+++G++M+ +  I+FI
Sbjct: 184 PGKTLVIGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQDMAERVGKYMK-DIGIKFI 242

Query: 240 RGCVPQSI--MKLENGQ--LLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           R  VP S+  + + +G+  L V +T  D G   ++ FDTVL A GRDP    +GLD AGV
Sbjct: 243 RPAVPLSVEAITMNDGKKVLNVNYTMLDNGNKAQDKFDTVLLAIGRDPCTVNIGLDNAGV 302

Query: 295 KLNPKTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYD 353
            +  K G I   NEQT+ P++Y IGD++ D PELTPVAI AGRLLA+RL    T   DYD
Sbjct: 303 VVE-KNGYIKTVNEQTNVPSIYGIGDILYDKPELTPVAIHAGRLLAKRLSGVSTQQCDYD 361

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            + T +FTP+EY CCGLSEE +IEK G+D +E+YH  F PLEW++        +SCY+K+
Sbjct: 362 SIPTTIFTPLEYSCCGLSEEVAIEKLGDD-VEVYHAQFMPLEWTIPHRDE---NSCYLKL 417

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K   + V+G H LGPN+GEV Q    AMK G T     + VGIHPT AE FTTL +T
Sbjct: 418 ICNKRDQERVIGIHILGPNSGEVMQGFATAMKCGATKAHFDDTVGIHPTNAEWFTTLRIT 477

Query: 474 K 474
           +
Sbjct: 478 R 478


>ref|NP_001171529.1| thioredoxin reductase 3 isoform 1 [Mus musculus]
          Length = 652

 Score =  486 bits (1252), Expect = e-135
 Identities = 253/482 (52%), Positives = 338/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 164 HDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLM 223

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G  + +D+K +GW   +Q   +W  M +++ S+I S+N+ Y+V LR+K V Y N
Sbjct: 224 HQAALLGHAL-QDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVN 282

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F+D H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 283 SFGEFVDLHKIKATN-KKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 341

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG TLVVGASYV LECAGF+ G+G DV +MVRS+LLRGFDQ+MA+K+G ++E +  ++F
Sbjct: 342 CPGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-QQGVKF 400

Query: 239 IRGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
            R   P  + +LE G      +V  +T   E  E  ++TVL A GRD    K+GL+K GV
Sbjct: 401 QRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGV 460

Query: 295 KLNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G+I V + EQT+ P+VYAIGD++D  PELTPVAIQAG+LLARRL+       DY
Sbjct: 461 KINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDY 520

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             + T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY K
Sbjct: 521 INIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---NTCYAK 577

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  ++ VVGFH LGPNAGE+TQ    AMK G T   + + +GIHPT  E+FTTLE+
Sbjct: 578 IICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEI 637

Query: 473 TK 474
           TK
Sbjct: 638 TK 639


>sp|Q99MD6|TRXR3_MOUSE RecName: Full=Thioredoxin reductase 3; AltName: Full=Thioredoxin
           and glutathione reductase; AltName: Full=Thioredoxin
           reductase TR2
          Length = 697

 Score =  486 bits (1252), Expect = e-135
 Identities = 253/482 (52%), Positives = 338/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 209 HDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLM 268

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G  + +D+K +GW   +Q   +W  M +++ S+I S+N+ Y+V LR+K V Y N
Sbjct: 269 HQAALLGHAL-QDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVN 327

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F+D H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 328 SFGEFVDLHKIKATN-KKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 386

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG TLVVGASYV LECAGF+ G+G DV +MVRS+LLRGFDQ+MA+K+G ++E +  ++F
Sbjct: 387 CPGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-QQGVKF 445

Query: 239 IRGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
            R   P  + +LE G      +V  +T   E  E  ++TVL A GRD    K+GL+K GV
Sbjct: 446 QRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGV 505

Query: 295 KLNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G+I V + EQT+ P+VYAIGD++D  PELTPVAIQAG+LLARRL+       DY
Sbjct: 506 KINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDY 565

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             + T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY K
Sbjct: 566 INIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---NTCYAK 622

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  ++ VVGFH LGPNAGE+TQ    AMK G T   + + +GIHPT  E+FTTLE+
Sbjct: 623 IICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEI 682

Query: 473 TK 474
           TK
Sbjct: 683 TK 684


>ref|XP_001630291.1| predicted protein [Nematostella vectensis]
 gb|EDO38228.1| predicted protein [Nematostella vectensis]
          Length = 593

 Score =  486 bits (1252), Expect = e-135
 Identities = 251/482 (52%), Positives = 342/482 (70%), Gaps = 14/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDL+VIGGGSGGLAC+KEAA+ G+KV VLD+VKP+  GT+WGLGGTCVNVGCIPKKL
Sbjct: 107 SYEYDLIVIGGGSGGLACAKEAAQLGRKVAVLDFVKPTPKGTTWGLGGTCVNVGCIPKKL 166

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+GE + KD++ +GW   E+   +W  + + V ++I S+N+ Y+V+LR+K V Y+
Sbjct: 167 MHQAALLGEAL-KDARLYGWEFDEKVKHNWESLREGVQNHIGSLNWGYRVQLREKSVTYK 225

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDV-VIAVGGRPK-PLACEGGDLAISSDDIFWRK 177
           N  G FID HT++    K+GT+T+ T +  V+A+G RP+ P      +  I+SDD+F   
Sbjct: 226 NAFGEFIDNHTIKA-TDKRGTETIMTAETFVLAMGLRPRYPNIPGAKEYGITSDDLFSLP 284

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG T+++GASYV+LECAGF+  MG DV ++VRSILLRGFDQ MA+K G FME    ++
Sbjct: 285 YCPGTTVLIGASYVSLECAGFLAAMGLDVTVVVRSILLRGFDQQMAEKAGSFMETHG-VK 343

Query: 238 FIRGCVPQSIMKLEN---GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           F R  VP  + +LE    G+L V +    GE      +TV+ A GRD     +GL+K GV
Sbjct: 344 FKRPAVPTKVEQLEEGSPGKLRVHYKLEGGEEGHLDCNTVVFAIGRDACTTGIGLEKVGV 403

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           KLNPK  ++   +NEQ+S PN+YAIGD++D   ELTPVAIQAGRLL+RRLY N+T L DY
Sbjct: 404 KLNPKNQKVIAGDNEQSSVPNIYAIGDILDGKLELTPVAIQAGRLLSRRLYRNDTKLCDY 463

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYG  G SEE +I+KFG++N+E+YH  F PLE++++  ++     CY K
Sbjct: 464 INVATTVFTPLEYGAIGYSEEDAIQKFGQENVEVYHTLFQPLEYTVAQRSK---DDCYAK 520

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K+  + VVGFH LGPNAGE+TQ   +A K G T +   + +GIHPT +E FT L+V
Sbjct: 521 LICNKADSERVVGFHVLGPNAGEITQGYAVAFKCGATKEHFDDTIGIHPTCSETFTLLDV 580

Query: 473 TK 474
           TK
Sbjct: 581 TK 582


>ref|XP_975772.1| PREDICTED: similar to thioredoxin reductase isoform 2 [Tribolium
           castaneum]
          Length = 492

 Score =  486 bits (1252), Expect = e-135
 Identities = 251/477 (52%), Positives = 337/477 (70%), Gaps = 11/477 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           +YDLVVIGGGSGGLA +KEAA  G KV VLDYV PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   EYDLVVIGGGSGGLAAAKEAAGLGAKVAVLDYVTPSPKGTKWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGETIHKDSKAFGWTVGEQ---TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           Q++L+GE I +D+K++GW   +      DWA + ++V ++IKS+N+  +VELRDKKV+Y 
Sbjct: 69  QAALLGEAI-EDAKSYGWQFPQPENIKHDWASLRQAVQNHIKSVNWVTRVELRDKKVEYI 127

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N LG F D HT+     K+G +T+T++  +IAVGGRP+     G  +  I+SDDIF  +E
Sbjct: 128 NGLGVFKDPHTVHT-VTKQGERTLTSKYFLIAVGGRPRYPNIPGAVEYGITSDDIFSLEE 186

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTLVVGA Y+ LECAGF++G+GYD  +MVRS++LRGFDQ MA  I   ME E  ++F
Sbjct: 187 APGKTLVVGAGYIGLECAGFLRGLGYDATVMVRSVVLRGFDQQMAKLIASAME-EKGVKF 245

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           +  C+P+S+ K  + +LLVKW+   G+  E+ FDTVL A GR     +L LDKAGVK+  
Sbjct: 246 LHKCLPKSVEKRSDNKLLVKWSNETGQEFEDVFDTVLFAIGRRALTRELHLDKAGVKVAG 305

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
              +I   NEQ++ P+++A+GDV+   PELTPVAI AGRLLARRL+ N T  MDYD V T
Sbjct: 306 DGEKIDAMNEQSNVPHIFAVGDVLYKKPELTPVAIHAGRLLARRLFGNSTVQMDYDNVAT 365

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VF+P+EYG  G+SEE +I++FGE+N+EIYH  + P E+ +    + + + CY+KV+  +
Sbjct: 366 TVFSPLEYGSVGISEETAIQRFGENNIEIYHAYYKPTEFFI---PQRSIAHCYLKVVAKR 422

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H++GP AGEV Q    AMK   T + +++ VGIHPT AE FT + +TK
Sbjct: 423 EGPQQVLGMHFIGPQAGEVIQGFAAAMKCNLTVNALMSTVGIHPTIAEEFTRINITK 479


>ref|NP_694802.2| thioredoxin reductase 3 isoform 2 [Mus musculus]
 gb|AAK31172.1|AF349659_1 thioredoxin and glutathione reductase [Mus musculus]
          Length = 615

 Score =  486 bits (1252), Expect = e-135
 Identities = 253/482 (52%), Positives = 338/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 127 HDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLM 186

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G  + +D+K +GW   +Q   +W  M +++ S+I S+N+ Y+V LR+K V Y N
Sbjct: 187 HQAALLGHAL-QDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVN 245

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F+D H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 246 SFGEFVDLHKIKATN-KKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 304

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG TLVVGASYV LECAGF+ G+G DV +MVRS+LLRGFDQ+MA+K+G ++E +  ++F
Sbjct: 305 CPGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-QQGVKF 363

Query: 239 IRGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
            R   P  + +LE G      +V  +T   E  E  ++TVL A GRD    K+GL+K GV
Sbjct: 364 QRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGV 423

Query: 295 KLNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G+I V + EQT+ P+VYAIGD++D  PELTPVAIQAG+LLARRL+       DY
Sbjct: 424 KINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDY 483

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             + T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY K
Sbjct: 484 INIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---NTCYAK 540

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  ++ VVGFH LGPNAGE+TQ    AMK G T   + + +GIHPT  E+FTTLE+
Sbjct: 541 IICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEI 600

Query: 473 TK 474
           TK
Sbjct: 601 TK 602


>gb|AAD25167.1|AF044212_1 thioredoxin reductase [Homo sapiens]
          Length = 521

 Score =  486 bits (1252), Expect = e-135
 Identities = 250/479 (52%), Positives = 341/479 (71%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 36  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 95

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 96  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 154

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 155 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 213

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 214 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 272

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 273 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 332

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP+AI AGRLL +RL+   + LMDYD V
Sbjct: 333 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNV 392

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 393 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 449

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 450 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 508


>ref|NP_006431.2| thioredoxin reductase 2, mitochondrial precursor [Homo sapiens]
 sp|Q9NNW7|TRXR2_HUMAN RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Selenoprotein Z; Short=SelZ; AltName: Full=TR-beta;
           AltName: Full=Thioredoxin reductase TR3; Flags:
           Precursor
 gb|AAD51324.1|AF171054_1 thioredoxin reductase TR3 [Homo sapiens]
          Length = 524

 Score =  486 bits (1252), Expect = e-135
 Identities = 250/479 (52%), Positives = 341/479 (71%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 99  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 157

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 158 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 216

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 217 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 275

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 276 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 335

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP+AI AGRLL +RL+   + LMDYD V
Sbjct: 336 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNV 395

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 396 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 452

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 453 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 511


>dbj|BAB28419.1| unnamed protein product [Mus musculus]
 dbj|BAC37890.1| unnamed protein product [Mus musculus]
 gb|AAH76605.1| Thioredoxin reductase 3 [Mus musculus]
 gb|EDK99269.1| thioredoxin reductase 3 [Mus musculus]
          Length = 613

 Score =  486 bits (1252), Expect = e-135
 Identities = 253/482 (52%), Positives = 338/482 (70%), Gaps = 15/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 127 HDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLM 186

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G  + +D+K +GW   +Q   +W  M +++ S+I S+N+ Y+V LR+K V Y N
Sbjct: 187 HQAALLGHAL-QDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVN 245

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F+D H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 246 SFGEFVDLHKIKATN-KKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 304

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG TLVVGASYV LECAGF+ G+G DV +MVRS+LLRGFDQ+MA+K+G ++E +  ++F
Sbjct: 305 CPGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-QQGVKF 363

Query: 239 IRGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
            R   P  + +LE G      +V  +T   E  E  ++TVL A GRD    K+GL+K GV
Sbjct: 364 QRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGV 423

Query: 295 KLNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N K G+I V + EQT+ P+VYAIGD++D  PELTPVAIQAG+LLARRL+       DY
Sbjct: 424 KINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDY 483

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             + T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY K
Sbjct: 484 INIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---NTCYAK 540

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC+K  ++ VVGFH LGPNAGE+TQ    AMK G T   + + +GIHPT  E+FTTLE+
Sbjct: 541 IICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEI 600

Query: 473 TK 474
           TK
Sbjct: 601 TK 602


>gb|AAD19597.1| thioredoxin reductase [Homo sapiens]
          Length = 524

 Score =  486 bits (1251), Expect = e-135
 Identities = 250/479 (52%), Positives = 341/479 (71%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 99  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 157

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 158 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 216

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 217 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 275

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 276 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 335

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP+AI AGRLL +RL+   + LMDYD V
Sbjct: 336 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNV 395

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 396 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 452

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 453 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 511


>ref|XP_002920642.1| PREDICTED: thioredoxin reductase 2, mitochondrial-like [Ailuropoda
           melanoleuca]
          Length = 493

 Score =  486 bits (1250), Expect = e-135
 Identities = 250/478 (52%), Positives = 336/478 (70%), Gaps = 12/478 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+VIGGGSGGLAC+KEAA+ GKKV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 11  DYDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVEPSPRGTRWGLGGTCVNVGCIPKKLMH 70

Query: 63  QSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           Q++L+G  I +D+  +GW V     DW  M ++V +Y+KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 71  QAALLGGMI-RDAPHYGWAVQPVLHDWRTMAEAVQNYVKSLNWGHRVQLQDRKVKYFNIK 129

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEA 179
            SF++ HT+     K G +T+ + + +VIA GGRPK P   EG  +  I+SDDIFW KE+
Sbjct: 130 ASFVNEHTV-CGVAKDGKETLLSAEHIVIATGGRPKYPTHIEGALEYGITSDDIFWLKES 188

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E+M  +    F+
Sbjct: 189 PGKTLVVGASYVALECAGFLTGLGLDTTVMIRSIPLRGFDQQMSSLVTEYMASQG-TRFL 247

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           RGC P  +  L +GQL V W     G+     F+TVL A GR P+   L L+KAGV  NP
Sbjct: 248 RGCTPSRVRGLPDGQLQVTWEDLTSGKEDMGTFNTVLWAIGRIPETRSLNLEKAGVNTNP 307

Query: 299 KTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
            + +I V+  E TS P++YAIGD+ +  PELTP AI AG+LLA+RL    + +MDYD V 
Sbjct: 308 NSQKILVDAQETTSVPHIYAIGDIAEGRPELTPTAIMAGKLLAQRLCGQSSDVMDYDNVP 367

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EYGC GLSEE ++ + GE+++E+YH  + PLE++++      AS CY+K++C 
Sbjct: 368 TTVFTPLEYGCVGLSEEEAVARHGEEHVEVYHAYYKPLEFTVAERD---ASQCYIKMVCL 424

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT AE    L ++K
Sbjct: 425 RKPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCAEEVAKLRISK 482


>gb|AAI17355.1| TXNRD2 protein [Homo sapiens]
 gb|ADR83199.1| Unknown protein [synthetic construct]
          Length = 492

 Score =  485 bits (1249), Expect = e-135
 Identities = 250/479 (52%), Positives = 340/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 69  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 127

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 128 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 186

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 187 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 245

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 246 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 305

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 306 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 365

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 366 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 422

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 423 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 481


>dbj|BAA77601.2| thioredoxin reductase II alpha [Homo sapiens]
          Length = 524

 Score =  485 bits (1249), Expect = e-135
 Identities = 250/479 (52%), Positives = 340/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 99  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 157

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 158 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 216

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 217 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 275

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 276 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 335

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 336 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 395

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 396 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 452

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 453 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 511


>dbj|BAA77602.2| thioredoxin reductase II beta [Homo sapiens]
          Length = 494

 Score =  485 bits (1249), Expect = e-135
 Identities = 250/479 (52%), Positives = 340/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 69  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 127

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 128 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 186

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 187 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 245

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 246 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 305

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 306 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 365

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 366 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 422

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 423 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 481


>gb|EFN85970.1| Thioredoxin reductase 1, mitochondrial [Harpegnathos saltator]
          Length = 544

 Score =  485 bits (1248), Expect = e-135
 Identities = 245/478 (51%), Positives = 334/478 (69%), Gaps = 10/478 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLA +KEA   G KV VLDYV PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 59  YKYDLLVIGGGSGGLAAAKEAVGLGAKVAVLDYVSPSPRGTTWGLGGTCVNVGCIPKKLM 118

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ---TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ++L+GE IH ++  FGW + +      DW  +  +V +++KS+N+  +VELR K++ Y
Sbjct: 119 HQAALLGEAIH-EAATFGWQLPDPKTIKIDWEALRTAVQNHVKSVNWVTRVELRTKEIDY 177

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LG F DAHT+     K   K +T +++++AVGGRP+     G  +  ISSDDIF  +
Sbjct: 178 INALGHFKDAHTIAGITKKGEEKIITAKNILLAVGGRPRYPDIPGALEYGISSDDIFSLE 237

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
            APGKTLVVGA Y+ LECAGF+ G+GYD  +MVRSI+LRGFDQ MA+ + E M+ +  + 
Sbjct: 238 HAPGKTLVVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMANIVAEEMQ-QRGVH 296

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           FI    P+ + K ++G+LLV W   DGE  ++ +DTVL A GR P   +L  + AG+KL+
Sbjct: 297 FIYQAKPKKVAKQDDGRLLVDWVDKDGEVHQDVYDTVLFAIGRRPLTEELKPENAGLKLH 356

Query: 298 PKTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
            ++G+I   NEQT+ PN+YA+GD++   PELTPVAI AG+LLA+RL++N +  MDY  V 
Sbjct: 357 SESGKIEATNEQTNVPNIYAVGDILHKKPELTPVAIHAGKLLAKRLFDNSSEQMDYTNVA 416

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VF+P+EYGC GLSEEA++  +GE+ +E+YH  + P E+ +    +   S CYVKVI  
Sbjct: 417 TTVFSPLEYGCVGLSEEAAVAHYGEEEIEVYHAYYKPTEFFV---PQKDVSHCYVKVIAL 473

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           ++ D+ V+G H++GPNAGEV Q    A+K G T+ ++ + VGIHPTTAE FT L +TK
Sbjct: 474 RNGDQKVLGMHFVGPNAGEVIQGFSAAVKCGLTFPKLKSTVGIHPTTAEEFTRLFITK 531


>dbj|BAD92961.1| thioredoxin reductase 2 isoform 1 precursor variant [Homo sapiens]
          Length = 511

 Score =  485 bits (1248), Expect = e-135
 Identities = 250/479 (52%), Positives = 340/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 28  DYDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 87

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 88  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 146

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 147 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 205

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 206 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 264

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 265 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 324

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 325 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 384

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 385 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 441

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 442 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 500


>gb|AAG47635.1|AF201385_1 mitochondrial thioredoxin reductase [Homo sapiens]
          Length = 521

 Score =  485 bits (1248), Expect = e-135
 Identities = 250/479 (52%), Positives = 340/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 38  DYDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 97

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 98  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 156

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 157 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 215

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 216 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 274

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 275 LRGCAPSRVKRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 334

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 335 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 394

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 395 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 451

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 452 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 510


>ref|XP_002830900.1| PREDICTED: thioredoxin reductase 2, mitochondrial-like [Pongo
           abelii]
          Length = 522

 Score =  484 bits (1247), Expect = e-134
 Identities = 250/479 (52%), Positives = 340/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 99  QAALLGGLI-QDAPHYGWEVAQPVLHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 157

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 158 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 216

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 217 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSLVIEHM-ASHGTRF 275

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W   A G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 276 LRGCAPSRVRRLPDGQLQVTWEDRATGKEDMGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 335

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 336 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 395

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 396 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 452

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + ++G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 453 LREPPQLLLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 511


>ref|NP_001171641.1| thioredoxin reductase 3 isoform 1 [Rattus norvegicus]
          Length = 652

 Score =  484 bits (1247), Expect = e-134
 Identities = 252/483 (52%), Positives = 338/483 (69%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T+DYDL+VIGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKL
Sbjct: 163 THDYDLIVIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 222

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G  + +D++ +GW   +Q   +W  M +++ ++I S+N+ Y+V LR+K V Y 
Sbjct: 223 MHQAALLGHAL-QDARKYGWDYNQQVKHNWETMREAIQNHIGSLNWGYRVTLREKGVTYV 281

Query: 120 NLLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N  G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F   
Sbjct: 282 NSFGEFVELHKIKATN-KKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLP 340

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG TL+VGASYV LECAGF+ G+G DV +MVRS+LLRGFDQ+MA+K+G ++E +  ++
Sbjct: 341 YCPGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-QQGVK 399

Query: 238 FIRGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           F R   P  + +LE G      +V  +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 400 FQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGLEKIG 459

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K G+I V + EQT+ P+VYAIGDV++  PELTPVAIQAG+LLARRL+       D
Sbjct: 460 VKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISLEKCD 519

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY 
Sbjct: 520 YINVPTTVFTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDN---NTCYA 576

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K  +  V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTT+E
Sbjct: 577 KIICNKFDNDRVIGFHLLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTME 636

Query: 472 VTK 474
           +TK
Sbjct: 637 ITK 639


>ref|NP_001100079.2| thioredoxin reductase 3 isoform 2 [Rattus norvegicus]
          Length = 615

 Score =  484 bits (1247), Expect = e-134
 Identities = 252/483 (52%), Positives = 338/483 (69%), Gaps = 15/483 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T+DYDL+VIGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKL
Sbjct: 126 THDYDLIVIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 185

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G  + +D++ +GW   +Q   +W  M +++ ++I S+N+ Y+V LR+K V Y 
Sbjct: 186 MHQAALLGHAL-QDARKYGWDYNQQVKHNWETMREAIQNHIGSLNWGYRVTLREKGVTYV 244

Query: 120 NLLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N  G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F   
Sbjct: 245 NSFGEFVELHKIKATN-KKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLP 303

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG TL+VGASYV LECAGF+ G+G DV +MVRS+LLRGFDQ+MA+K+G ++E +  ++
Sbjct: 304 YCPGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-QQGVK 362

Query: 238 FIRGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           F R   P  + +LE G      +V  +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 363 FQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGLEKIG 422

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K G+I V + EQT+ P+VYAIGDV++  PELTPVAIQAG+LLARRL+       D
Sbjct: 423 VKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISLEKCD 482

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGCCGLSEE +IE + ++NLE+YH  F PLEW+++       ++CY 
Sbjct: 483 YINVPTTVFTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDN---NTCYA 539

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K  +  V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTT+E
Sbjct: 540 KIICNKFDNDRVIGFHLLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTME 599

Query: 472 VTK 474
           +TK
Sbjct: 600 ITK 602


>ref|NP_001152971.1| thioredoxin reductase 2 precursor [Macaca mulatta]
          Length = 524

 Score =  484 bits (1245), Expect = e-134
 Identities = 249/479 (51%), Positives = 339/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+VIGGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVIGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 99  QAALLGGLI-QDAPHYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 157

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 158 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 216

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E M      +F
Sbjct: 217 SPGKTLVVGASYVALECAGFLTGIGLDTTVMIRSIPLRGFDQQMSSMVIEHM-ASHGTQF 275

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +G L V W     G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 276 LRGCAPSRVRRLPDGHLQVTWEDCTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 335

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 336 PDTQKILVDSREGTSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 395

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 396 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 452

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 453 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 511


>gb|AAH07489.3| TXNRD2 protein [Homo sapiens]
          Length = 485

 Score =  484 bits (1245), Expect = e-134
 Identities = 249/478 (52%), Positives = 340/478 (71%), Gaps = 13/478 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 1   YDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQ 60

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 61  AALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 119

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEA 179
            SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE+
Sbjct: 120 ASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKES 178

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F+
Sbjct: 179 PGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRFL 237

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +P
Sbjct: 238 RGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSP 297

Query: 299 KTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
            T +I V++ E TS P++YAIGDV++  PELTP+AI AGRLL +RL+   + LMDYD V 
Sbjct: 298 DTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVP 357

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C 
Sbjct: 358 TTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVCL 414

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 415 REPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 472


>emb|CAF96941.1| unnamed protein product [Tetraodon nigroviridis]
          Length = 629

 Score =  484 bits (1245), Expect = e-134
 Identities = 267/511 (52%), Positives = 338/511 (66%), Gaps = 44/511 (8%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAALLGKKVMVLDYVVPTPKGTSWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+  T  +D++ FGW   E  T +W  M  ++N YI S+N+ Y+V LRDK V Y N
Sbjct: 174 HQTALL-RTAIQDARKFGWEFDEAVTHNWETMKTAINDYIGSLNWGYRVSLRDKNVNYVN 232

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
               F+D H ++  + K+G +T  T    V+A G RP+ L   G  +  I+SDD+F    
Sbjct: 233 AYAEFVDPHKIKATN-KRGKETFYTAARFVLATGERPRYLGVPGDKEYCITSDDLFSLPY 291

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLV+GASYVALEC GF+ G+G DV +MVRSILLRGFDQDMA++ G++ME E  ++F
Sbjct: 292 CPGKTLVIGASYVALECGGFLAGLGLDVTVMVRSILLRGFDQDMANRAGQYME-EHGVKF 350

Query: 239 IRGCVP--------------------------QSIMKLEN------GQLLV-KWTTADGE 265
           +R  VP                           S+ ++E       G+L V   +T   E
Sbjct: 351 LRKYVPVQVGGPRKRAGVGARLVLHVQKSSSLTSVWQIEELEAGTPGRLKVTAKSTESDE 410

Query: 266 ACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDA 324
             EE ++TVL A GR+    K+GLDK GVK+NPK G+I V + EQTS P++YAIGD+++ 
Sbjct: 411 IIEEEYNTVLIAVGRNACTDKIGLDKVGVKVNPKNGKIPVNDEEQTSVPHIYAIGDILEE 470

Query: 325 P-ELTPVAIQAGRLLARRLYNNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDN 383
             ELTPVAIQAGRLLARRLY       DY  V T VFTP+EYG CGLSEE ++  +G++N
Sbjct: 471 KWELTPVAIQAGRLLARRLYGGSKVKCDYVNVPTTVFTPMEYGACGLSEERAVGLYGQEN 530

Query: 384 LEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLA 443
           +E++H  F PLE+++        + CY K+IC+K     VVGFHYLGPNAGEVTQ    A
Sbjct: 531 IEVFHTQFWPLEFTVPGRDN---NKCYAKIICNKLDSGRVVGFHYLGPNAGEVTQGFSAA 587

Query: 444 MKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           MK G T +Q+   +GIHPT AEIFTTLEVTK
Sbjct: 588 MKCGATKEQLDGTIGIHPTCAEIFTTLEVTK 618


>gb|EFX87625.1| hypothetical protein DAPPUDRAFT_306444 [Daphnia pulex]
          Length = 611

 Score =  483 bits (1244), Expect = e-134
 Identities = 253/485 (52%), Positives = 334/485 (68%), Gaps = 17/485 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLA SKEAA  G KV V D+V P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 121 YDYDLVVIGGGSGGLAASKEAAMLGAKVAVCDFVVPTPIGTAWGLGGTCVNVGCIPKKLM 180

Query: 62  HQSSLIGETIHKDSKAFGWTVGE-QTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++++G+++  D+K FGW + E  T +W  M++++ ++I S+N+ Y+V LR+KKV Y N
Sbjct: 181 HQAAILGQSV-SDAKKFGWELPETATHNWKTMVEAIQAHIGSLNWGYRVALREKKVNYLN 239

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
               F+D HTL+    KK   T+T + +++A GGRP+     G  +  I+SDDIF     
Sbjct: 240 AFAEFVDPHTLKTTDKKKKETTITAKYILLATGGRPRYPDIPGAQEFGITSDDIFSLPRH 299

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTL+VGASY+ALECAGF+ G+G D  +MVRSILLRGFDQ MA+ IG +ME +  I F 
Sbjct: 300 PGKTLLVGASYIALECAGFLAGLGIDATVMVRSILLRGFDQQMANLIGSYME-KHGIRFQ 358

Query: 240 RGCVPQSIMKLEN--------GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDK 291
            G VP  + ++E          ++ V      GE  EE ++TVL A GRD    K+G++K
Sbjct: 359 HGYVPTKLERIEEACIEKGTPARIKVTSQNEQGELMEEEYNTVLFAIGRDACTNKIGIEK 418

Query: 292 AGVKLNPKTGR-IWVENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTL 349
           A V LNPK G+ I  E EQT+ P++YAIGD++D   ELTPVAIQAGRLLA+RL+ N T L
Sbjct: 419 ANVMLNPKNGKVICDEKEQTNIPHIYAIGDILDGKLELTPVAIQAGRLLAQRLFGNGTLL 478

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
            DY  V T VFTP+EYGCCGLSEE +I+K+G  ++E+YH   TPLE    +  +   +  
Sbjct: 479 TDYVNVPTTVFTPLEYGCCGLSEEDAIDKYGAKDIEVYHSYLTPLE---VTVPKRDDNEG 535

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y K+IC KS ++ VVG H + PNAGE+TQ   + +KLG T     N++GIHPT AE+FTT
Sbjct: 536 YAKLICVKSLNEKVVGLHIVSPNAGEITQGFAIGLKLGATKADFDNLIGIHPTIAEVFTT 595

Query: 470 LEVTK 474
           L+ TK
Sbjct: 596 LKSTK 600


>ref|XP_850181.1| PREDICTED: similar to thioredoxin reductase 2 isoform 1 precursor
           [Canis familiaris]
          Length = 509

 Score =  483 bits (1243), Expect = e-134
 Identities = 252/479 (52%), Positives = 336/479 (70%), Gaps = 13/479 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           +YDL+VIGGGSGGLAC+KEAA+ GKKV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 26  NYDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 85

Query: 63  QSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW  M ++V +++KS+N+ ++V+L+D+KV Y N+
Sbjct: 86  QAALLGSMI-RDAPHYGWDVAQPVLHDWRTMAEAVQNHVKSLNWGHRVQLQDRKVTYFNV 144

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF++ HT+     K G +T+ + + +VIA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 145 KASFVNEHTV-CGVAKGGKETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDIFWLKE 203

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E+M  +    F
Sbjct: 204 SPGKTLVVGASYVALECAGFLTGLGLDTTIMIRSIPLRGFDQQMSSLVTEYMASQG-TRF 262

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W     G+     FDTVL A GR P+   L L+KAGV  N
Sbjct: 263 LRGCTPSRVRRLPDGQLQVTWENLTSGKEDVGTFDTVLWAIGRIPETKSLNLEKAGVNTN 322

Query: 298 PKTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P + +I V   E TS P++YAIGDV +  PELTP AI AGRLLA+RL    + +MDYD V
Sbjct: 323 PNSQKILVNAQEATSIPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLCGQASDVMDYDNV 382

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + GE+++E+YH  + PLE++++      AS CYVK++C
Sbjct: 383 PTTVFTPLEYGCVGLSEEEAVTRHGEEHVEVYHAYYKPLEFTVAERD---ASQCYVKMVC 439

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT AE    L +TK
Sbjct: 440 LRKPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCAEEVAKLRITK 498


>ref|XP_002713123.1| PREDICTED: Thioredoxin reductase 3-like, partial [Oryctolagus
           cuniculus]
          Length = 673

 Score =  483 bits (1242), Expect = e-134
 Identities = 248/481 (51%), Positives = 338/481 (70%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDL+VIGGGSGGL+C+KEAA  G+KV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 187 YEYDLIVIGGGSGGLSCAKEAAILGRKVMVLDFVVPSPRGTSWGLGGTCVNVGCIPKKLM 246

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ + +DS+ FGW   +Q   +W  M +++ ++I S+N+ Y++ LR++ V Y N
Sbjct: 247 HQAALLGQAL-RDSRKFGWEYSQQVKHNWETMTEAIQNHIGSLNWGYRLSLRERGVTYVN 305

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ HT++  + K      T+ + VIA G RP+ L   G  +  I+SDD+F     
Sbjct: 306 SYGEFVEHHTVKATNRKGQETYYTSANFVIATGERPRYLGIPGDKEFCITSDDLFSLPYC 365

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQ++A+K+G +M+ +  ++F+
Sbjct: 366 PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEVAEKVGSYMQ-QHGVKFL 424

Query: 240 RGCVPQSIMKLEN---GQLLVKWTTADG-EACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + +LE    G+L V   + +G E  E  ++TVL A GRD     +GL+K GV+
Sbjct: 425 RKFVPVMVQQLEKGSPGKLKVTAKSTEGPETIEGVYNTVLLAIGRDSCTRNIGLEKIGVR 484

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +N K G+I V + EQT+ P VYA+GDV++  PELTPVAIQAG+LLARRL+   +   DY 
Sbjct: 485 INEKNGKIPVNDVEQTNVPYVYAVGDVLEGKPELTPVAIQAGKLLARRLHGASSEKCDYF 544

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            + T VFTP+EYGCCGLSEE + E + ++NLE+YH  F PLEW+++       ++CY K+
Sbjct: 545 SIPTTVFTPLEYGCCGLSEEKATELYMKENLEVYHTLFWPLEWTVAGRDN---NTCYAKI 601

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K     V+GFH LGPNAGE+TQ    AMK G T   +   +GIHPT  E+FTTLE+T
Sbjct: 602 ICNKLDQDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDETIGIHPTCGEVFTTLEIT 661

Query: 474 K 474
           K
Sbjct: 662 K 662


>pdb|2X8C|A Chain A, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           With The Reduced C-Terminal End
 pdb|2X8C|B Chain B, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           With The Reduced C-Terminal End
 pdb|2X8G|A Chain A, Oxidized Thioredoxin Glutathione Reductase From
           Schistosoma Mansoni
 pdb|2X8H|A Chain A, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           In Complex With Gsh
 pdb|2X99|A Chain A, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           In Complex With Nadph
          Length = 598

 Score =  482 bits (1241), Expect = e-134
 Identities = 249/485 (51%), Positives = 332/485 (68%), Gaps = 17/485 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAAKYG K  VLDYV+P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ--TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+ L+   + +D++ FGW++     + +W+ M++ V S+I S+N+ YKV LRD +V Y 
Sbjct: 166 HQAGLLSHAL-EDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYL 224

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G  I  H +++    +   T+T   +++A G RPK     G  +  I+SDD+F    
Sbjct: 225 NAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFSLPY 284

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLV+GASYVALECAGF+  +G DV +MVRSILLRGFDQ MA+K+G++ME    ++F
Sbjct: 285 FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NHGVKF 343

Query: 239 IRGCVPQSIMKL-----EN---GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLD 290
            + CVP  I +L     EN   G LLVK    DG+  EE F+TV+ A GR+P ++K+  +
Sbjct: 344 AKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLCE 403

Query: 291 KAGVKLNPKTGRIWVENEQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTL 349
             GVKL+     +  ++EQT+  NVYAIGD+    P+LTPVAIQAGR LARRL+   T L
Sbjct: 404 TVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATEL 463

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
            DY  V T VFTP+EYG CGLSEE +IEK+G+ ++E+YH NF PLEW+++       + C
Sbjct: 464 TDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVA---HREDNVC 520

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y+K++C KS +  V+G H LGPNAGE+TQ   +A+K+G T       +GIHPT +E FTT
Sbjct: 521 YMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTT 580

Query: 470 LEVTK 474
           L VTK
Sbjct: 581 LHVTK 585


>pdb|3H4K|A Chain A, Crystal Structure Of The Wild Type Thioredoxin Glutatione
           Reductase From Schistosoma Mansoni In Complex With
           Auranofin
          Length = 598

 Score =  482 bits (1241), Expect = e-134
 Identities = 249/485 (51%), Positives = 332/485 (68%), Gaps = 17/485 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAAKYG K  VLDYV+P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ--TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+ L+   + +D++ FGW++     + +W+ M++ V S+I S+N+ YKV LRD +V Y 
Sbjct: 166 HQAGLLSHAL-EDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYL 224

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G  I  H +++    +   T+T   +++A G RPK     G  +  I+SDD+F    
Sbjct: 225 NAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFSLPY 284

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLV+GASYVALECAGF+  +G DV +MVRSILLRGFDQ MA+K+G++ME    ++F
Sbjct: 285 FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NHGVKF 343

Query: 239 IRGCVPQSIMKL-----EN---GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLD 290
            + CVP  I +L     EN   G LLVK    DG+  EE F+TV+ A GR+P ++K+  +
Sbjct: 344 AKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLCE 403

Query: 291 KAGVKLNPKTGRIWVENEQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTL 349
             GVKL+     +  ++EQT+  NVYAIGD+    P+LTPVAIQAGR LARRL+   T L
Sbjct: 404 TVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATEL 463

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
            DY  V T VFTP+EYG CGLSEE +IEK+G+ ++E+YH NF PLEW+++       + C
Sbjct: 464 TDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVA---HREDNVC 520

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y+K++C KS +  V+G H LGPNAGE+TQ   +A+K+G T       +GIHPT +E FTT
Sbjct: 521 YMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTT 580

Query: 470 LEVTK 474
           L VTK
Sbjct: 581 LHVTK 585


>pdb|2V6O|A Chain A, Structure Of Schistosoma Mansoni Thioredoxin-Glutathione
           Reductase (Smtgr)
          Length = 596

 Score =  482 bits (1241), Expect = e-134
 Identities = 249/485 (51%), Positives = 332/485 (68%), Gaps = 17/485 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAAKYG K  VLDYV+P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ--TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+ L+   + +D++ FGW++     + +W+ M++ V S+I S+N+ YKV LRD +V Y 
Sbjct: 166 HQAGLLSHAL-EDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYL 224

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G  I  H +++    +   T+T   +++A G RPK     G  +  I+SDD+F    
Sbjct: 225 NAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFSLPY 284

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLV+GASYVALECAGF+  +G DV +MVRSILLRGFDQ MA+K+G++ME    ++F
Sbjct: 285 FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NHGVKF 343

Query: 239 IRGCVPQSIMKL-----EN---GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLD 290
            + CVP  I +L     EN   G LLVK    DG+  EE F+TV+ A GR+P ++K+  +
Sbjct: 344 AKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLCE 403

Query: 291 KAGVKLNPKTGRIWVENEQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTL 349
             GVKL+     +  ++EQT+  NVYAIGD+    P+LTPVAIQAGR LARRL+   T L
Sbjct: 404 TVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATEL 463

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
            DY  V T VFTP+EYG CGLSEE +IEK+G+ ++E+YH NF PLEW+++       + C
Sbjct: 464 TDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVA---HREDNVC 520

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y+K++C KS +  V+G H LGPNAGE+TQ   +A+K+G T       +GIHPT +E FTT
Sbjct: 521 YMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTT 580

Query: 470 LEVTK 474
           L VTK
Sbjct: 581 LHVTK 585


>gb|AAW25951.1| SJCHGC06622 protein [Schistosoma japonicum]
          Length = 615

 Score =  482 bits (1241), Expect = e-134
 Identities = 247/485 (50%), Positives = 334/485 (68%), Gaps = 17/485 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA  KEAAKYG K  VLDYV+P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 125 YDYDLIIIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLM 184

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ--TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+ L+  ++ +D++ FGW++ +   + DW+ M++ V S+I S+N+ YKV LRD  V Y 
Sbjct: 185 HQAGLLSHSL-EDAQHFGWSLDKSKISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAVTYL 243

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G  ++ H +++    K   T+T   +++A G RPK     G  +  I+SDD+F    
Sbjct: 244 NARGMLLNPHEVQITEKNKKVSTITGNKIILATGERPKYPEIPGAIEYGITSDDLFSLPY 303

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+  +G DV +MVRSILLRGFDQ MA+K+G++ME    ++F
Sbjct: 304 FPGKTLVVGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NHGVKF 362

Query: 239 IRGCVPQSIMKL-----EN---GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLD 290
            + CVP  I +L     EN   G LLVK    DG+  EE F+TV+ A GR+P ++KL  +
Sbjct: 363 AKLCVPDEITQLKPVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKLNCE 422

Query: 291 KAGVKLNPKTGRIWVENEQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTL 349
             GVKL+     +  ++EQT+  N+YAIGD+    P+LTPVAI AGR LARRL+   T L
Sbjct: 423 AVGVKLDKNGRVVCSDDEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAGATEL 482

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
            DY  V T VFTP+EYG CGLSEE +IEK+G++++E+YH +F PLEW+++       + C
Sbjct: 483 TDYSNVATTVFTPLEYGACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVA---HREDNVC 539

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y+K++C  S +  V+G H LGPNAGE+TQ   +A+K+G T +     +GIHPT +E FTT
Sbjct: 540 YMKLVCRISDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHPTCSETFTT 599

Query: 470 LEVTK 474
           L VTK
Sbjct: 600 LHVTK 604


>gb|AAK85233.1|AF395822_1 thioredoxin glutathione reductase [Schistosoma mansoni]
          Length = 598

 Score =  482 bits (1241), Expect = e-134
 Identities = 249/485 (51%), Positives = 332/485 (68%), Gaps = 17/485 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAAKYG K  VLDYV+P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ--TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+ L+   + +D++ FGW++     + +W+ M++ V S+I S+N+ YKV LRD +V Y 
Sbjct: 166 HQAGLLSHAL-EDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYL 224

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G  I  H +++    +   T+T   +++A G RPK     G  +  I+SDD+F    
Sbjct: 225 NAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFSLPY 284

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLV+GASYVALECAGF+  +G DV +MVRSILLRGFDQ MA+K+G++ME    ++F
Sbjct: 285 FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NHGVKF 343

Query: 239 IRGCVPQSIMKL-----EN---GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLD 290
            + CVP  I +L     EN   G LLVK    DG+  EE F+TV+ A GR+P ++K+  +
Sbjct: 344 AKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLCE 403

Query: 291 KAGVKLNPKTGRIWVENEQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTL 349
             GVKL+     +  ++EQT+  NVYAIGD+    P+LTPVAIQAGR LARRL+   T L
Sbjct: 404 TVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATEL 463

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
            DY  V T VFTP+EYG CGLSEE +IEK+G+ ++E+YH NF PLEW+++       + C
Sbjct: 464 TDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVA---HREDNVC 520

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y+K++C KS +  V+G H LGPNAGE+TQ   +A+K+G T       +GIHPT +E FTT
Sbjct: 521 YMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTT 580

Query: 470 LEVTK 474
           L VTK
Sbjct: 581 LHVTK 585


>ref|NP_001162173.1| thioredoxin reductase 2, mitochondrial [Sus scrofa]
 gb|ACZ63265.1| thioredoxin reductase 2 [Sus scrofa]
          Length = 513

 Score =  480 bits (1236), Expect = e-133
 Identities = 253/479 (52%), Positives = 332/479 (69%), Gaps = 15/479 (3%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA+ GKKV V+DYV PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 31  YDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVSPSPRGTRWGLGGTCVNVGCIPKKLMHQ 90

Query: 64  SSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +     W +M ++V +++KS+N+ ++V+L+D+KVKY N  
Sbjct: 91  AALLGGVI-RDAPHYGWEVVQPALHSWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNFK 149

Query: 123 GSFIDAHTLELWHPKKGTKTV--TTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
            SF++ HT  +    KG K +  +   +VIA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 150 ASFVNKHT--VCGVSKGGKEILLSAEHIVIATGGRPRYPAHIEGAVEYGITSDDIFWLKE 207

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LR FDQ MA  + E M V      
Sbjct: 208 SPGKTLVVGASYVALECAGFLTGLGLDATIMIRSIPLRAFDQQMASLVIEHMAVHG-TRI 266

Query: 239 IRGCVPQSIMKLENGQLLVKWT-TADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           ++GC+P  + KL +GQL V W   A        FDTVL ATGR P++  L L+KAGV  N
Sbjct: 267 LKGCMPLRVEKLPDGQLQVTWVDLASDRKDVGTFDTVLWATGRVPEIGSLNLEKAGVHTN 326

Query: 298 PKTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V+  + TS P++YAIGDV +  PELTP A+ AGRLLA+RL    + LMDYD V
Sbjct: 327 PHTQKILVDAQDATSVPHIYAIGDVAEGRPELTPTAVMAGRLLAQRLCGRSSDLMDYDNV 386

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEEA++ + GE+ +E+YH  + PLE+++       AS CY+K++C
Sbjct: 387 PTTVFTPLEYGCVGLSEEAAVARHGEEGVEVYHAYYKPLEFTVPERD---ASQCYIKMVC 443

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V G H+LGPNAGEVTQ   LA+K G +Y+Q++  VGIHPT AE    L ++K
Sbjct: 444 LREPPQLVRGLHFLGPNAGEVTQGFALALKCGASYEQVMRTVGIHPTCAEEVAKLRISK 502


>gb|EFN67124.1| Thioredoxin reductase 1, mitochondrial [Camponotus floridanus]
          Length = 537

 Score =  479 bits (1234), Expect = e-133
 Identities = 250/478 (52%), Positives = 327/478 (68%), Gaps = 10/478 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLA +KEA     KV VLDYV PS +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 52  YTYDLLVIGGGSGGLAAAKEAVGLNAKVAVLDYVTPSPLGTTWGLGGTCVNVGCIPKKLM 111

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ---TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ++L+GE +H ++  FGW + +      +W  +  +V +++KS+N+  +VELR KKV Y
Sbjct: 112 HQAALLGEAVH-EAATFGWQLPDPKTVKINWEALKTAVQNHVKSVNWVTRVELRTKKVDY 170

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LG F+DAHT+     K   K  T ++++IAVGGRP+     G  +  ISSDDIF  +
Sbjct: 171 FNALGHFMDAHTVVGVTKKGEEKVFTAKNILIAVGGRPRYPDIPGALEYGISSDDIFSLE 230

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
            APGKTLVVGA Y+ LECAGF+ G+GYD  IMVRSI+LRGFDQ MA+ + E ME +  + 
Sbjct: 231 RAPGKTLVVGAGYIGLECAGFLNGLGYDTTIMVRSIVLRGFDQQMANLVAEEME-QRGVH 289

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           FI    P+ + K E+G+LLV W   DG+  ++ +DTVL A GR     +L  + AG+KL 
Sbjct: 290 FIYQAKPKKVAKQEDGRLLVDWVDKDGQIHQDVYDTVLFAIGRRALTEELKPENAGLKLV 349

Query: 298 PKTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
           P+T +I   NEQT+ PN+YA+GDV+   PELTPVAI AG+LLARRL++N T  MDY  V 
Sbjct: 350 PETNKIEAINEQTNVPNIYAVGDVLHKRPELTPVAIHAGKLLARRLFDNSTEQMDYTNVA 409

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VF+P+EYGC GLSEEA+I   GE+ +EIYH  + P E+ +    +     CYVKV+  
Sbjct: 410 TTVFSPLEYGCVGLSEEAAIGLHGEEEIEIYHAYYKPTEFFV---PQKDVDRCYVKVVAF 466

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +S D+ V+G H++GPNAGEV Q    A+K G T  ++   VGIHPT AE FT + VTK
Sbjct: 467 RSGDQRVLGIHFVGPNAGEVIQGFAAAIKCGLTIPKLKATVGIHPTVAEEFTRISVTK 524


>ref|XP_002596165.1| hypothetical protein BRAFLDRAFT_203192 [Branchiostoma floridae]
 gb|EEN52177.1| hypothetical protein BRAFLDRAFT_203192 [Branchiostoma floridae]
          Length = 487

 Score =  479 bits (1234), Expect = e-133
 Identities = 246/479 (51%), Positives = 332/479 (69%), Gaps = 11/479 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLACSKEAA+ G +V VLDYV PS  G+ WGLGG CVNVGCIPKKLM
Sbjct: 3   HDYDLVVVGGGSGGLACSKEAAQLGARVLVLDYVDPSPQGSRWGLGGCCVNVGCIPKKLM 62

Query: 62  HQSSLIGETIHKDSKAFGWTVG-EQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H ++L+G  + +DSK +GW    + T DW  +   V  ++KS+N+ ++V+L+DK+V Y+N
Sbjct: 63  HHAALLGHAV-QDSKKYGWNAHVDPTIDWTTLTTVVQQHVKSLNWGHRVQLKDKQVDYQN 121

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             GS +D HT+ +       KTVT  ++V+AVGGRPK     G  + AI+SDD+F  ++ 
Sbjct: 122 AKGSLLDPHTVRVVSANGKEKTVTASNIVLAVGGRPKYPDIPGAMEHAITSDDLFMLEKP 181

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLV+GASYV+LECAGF+ G+G+D  +M+RSI LRGFD+ MAD + + ME  S   F+
Sbjct: 182 PGKTLVIGASYVSLECAGFLTGLGFDTTVMIRSIPLRGFDRQMADLVTDHME-GSGTRFL 240

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           R  VP +I K ++GQL V W    G+  +  FDTV+ A GR  +   LGLD  GV+   +
Sbjct: 241 RQHVPSAIDKTDSGQLQVTWRDGSGQEGQGTFDTVMMAVGRFANTGTLGLDTVGVEWYSE 300

Query: 300 TGRI--WVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           +G++    EN EQ+S P+++AIGD++   PELTPVAI+AGRLLA RL+      MDYDKV
Sbjct: 301 SGKVIGREENPEQSSVPHIFAIGDILHGRPELTPVAIKAGRLLAHRLFAATREHMDYDKV 360

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYG  GLSEEA++E+FG D +EIYH  + PLE+ +       AS CY+K +C
Sbjct: 361 PTTVFTPLEYGSVGLSEEAALERFGPDQVEIYHAFYKPLEYYIPERD---ASQCYIKAVC 417

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +  D+ +VG H+LGPNAGEVTQ   +A++ G TY Q+ + VGIHPT AE    + +TK
Sbjct: 418 KRDGDQEIVGLHFLGPNAGEVTQGFAVALRSGLTYQQLASSVGIHPTCAEEVVKMGITK 476


>pdb|3DGZ|A Chain A, Crystal Structure Of Mouse Mitochondrial Thioredoxin
           Reductase, C-Terminal 3-Residue Truncation
          Length = 488

 Score =  479 bits (1233), Expect = e-133
 Identities = 246/477 (51%), Positives = 332/477 (69%), Gaps = 11/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 7   FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 66

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 67  AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 125

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 126 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 185

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 186 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 244

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 245 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 304

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V T
Sbjct: 305 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPT 364

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C +
Sbjct: 365 TVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQCYIKMVCMR 421

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 422 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 478


>gb|EDK97524.1| thioredoxin reductase 2, isoform CRA_a [Mus musculus]
          Length = 525

 Score =  479 bits (1233), Expect = e-133
 Identities = 246/477 (51%), Positives = 332/477 (69%), Gaps = 11/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 43  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 102

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 103 AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 161

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 162 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 221

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 222 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 280

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 281 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 340

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V T
Sbjct: 341 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPT 400

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C +
Sbjct: 401 TVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQCYIKMVCMR 457

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 458 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 514


>sp|Q9JLT4|TRXR2_MOUSE RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Thioredoxin reductase TR3; Flags: Precursor
 gb|AAD51323.1|AF171053_1 thioredoxin reductase TR3 [Mus musculus]
          Length = 524

 Score =  479 bits (1233), Expect = e-133
 Identities = 246/477 (51%), Positives = 332/477 (69%), Gaps = 11/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 40  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 99

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 100 AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 158

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 159 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 218

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 219 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 277

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 278 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 337

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V T
Sbjct: 338 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPT 397

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C +
Sbjct: 398 TVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQCYIKMVCMR 454

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 455 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 511


>gb|AAF03359.1|AF136399_1 thioredoxin reductase [Mus musculus]
          Length = 528

 Score =  479 bits (1233), Expect = e-133
 Identities = 246/477 (51%), Positives = 332/477 (69%), Gaps = 11/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 44  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 103

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 104 AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 162

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 163 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 222

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 223 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 281

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 282 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 341

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V T
Sbjct: 342 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPT 401

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C +
Sbjct: 402 TVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQCYIKMVCMR 458

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 459 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 515


>ref|NP_038739.2| thioredoxin reductase 2, mitochondrial precursor [Mus musculus]
 gb|AAL90457.1| thioredoxin reductase [Mus musculus]
 gb|AAH52157.3| Thioredoxin reductase 2 [Mus musculus]
          Length = 527

 Score =  479 bits (1233), Expect = e-133
 Identities = 246/477 (51%), Positives = 332/477 (69%), Gaps = 11/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 43  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 102

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 103 AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 161

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 162 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 221

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 222 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 280

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 281 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 340

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V T
Sbjct: 341 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPT 400

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C +
Sbjct: 401 TVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQCYIKMVCMR 457

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 458 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 514


>pdb|1ZDL|A Chain A, Crystal Structure Of Mouse Thioredoxin Reductase Type 2
 pdb|1ZKQ|A Chain A, Crystal Structure Of Mouse Thioredoxin Reductase Type 2
          Length = 517

 Score =  479 bits (1233), Expect = e-133
 Identities = 246/477 (51%), Positives = 332/477 (69%), Gaps = 11/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 33  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 92

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 93  AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 151

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 152 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 211

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 212 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 270

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 271 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 330

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V T
Sbjct: 331 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPT 390

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C +
Sbjct: 391 TVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQCYIKMVCMR 447

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 448 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 504


>dbj|BAA86986.2| thioredoxin reductase 2 [Mus musculus]
          Length = 520

 Score =  479 bits (1233), Expect = e-133
 Identities = 246/477 (51%), Positives = 332/477 (69%), Gaps = 11/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 36  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 95

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 96  AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 154

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 155 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 214

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 215 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 273

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 274 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 333

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V T
Sbjct: 334 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPT 393

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C +
Sbjct: 394 TVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQCYIKMVCMR 450

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 451 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 507


>ref|NP_777051.1| thioredoxin reductase 2, mitochondrial precursor [Bos taurus]
 sp|Q9N2I8|TRXR2_BOVIN RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Thioredoxin reductase TR3; Flags: Precursor
 dbj|BAA82153.1| thioredoxin reductase [Bos taurus]
          Length = 511

 Score =  479 bits (1233), Expect = e-133
 Identities = 248/477 (51%), Positives = 330/477 (69%), Gaps = 12/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA+ GKKV VLDYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 28  YDLLVIGGGSGGLACAKEAAQLGKKVAVLDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQ 87

Query: 64  SSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLLG 123
           ++L+G  I +D+  +GW V +    WA +  +V +++KS+N+ ++++L+D+KVKY N+  
Sbjct: 88  AALLGGMI-RDAPHYGWGVAQAPHSWATLADAVQNHVKSLNWGHRIQLQDRKVKYFNVKA 146

Query: 124 SFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
           SF+D HT+     K G +T+ + + +VIA GGRP+ P   EG  +  I+SDD+FW KE+P
Sbjct: 147 SFVDTHTV-CGVSKGGEETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDLFWLKESP 205

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAG + G+G D  +M+RS+ LR FDQ MA  + E M        +R
Sbjct: 206 GKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPLRAFDQQMASLVTEHMAGHG-TRILR 264

Query: 241 GCVPQSIMKLENGQLLVKWTTADGEACEE-AFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GC P+ + KL   QL V W     +  +   FDTVL A GR P+ A L L+KAGV  NP 
Sbjct: 265 GCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKAGVHTNPV 324

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           TG+I V+  E TS P++YAIGDV +  PELTP AI AGRLLA+RL    + LMDY  V T
Sbjct: 325 TGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLMDYSSVPT 384

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEEA++ + GE+++E+YH  + PLE+++       AS CY+K++C +
Sbjct: 385 TVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRD---ASQCYIKMVCLR 441

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEV Q   L +K G +Y Q++  VGIHPT AE    L ++K
Sbjct: 442 EPPQLVLGLHFLGPNAGEVIQGFALGIKCGASYQQLMRTVGIHPTCAEEVAKLRISK 498


>gb|EFZ12491.1| hypothetical protein SINV_11881 [Solenopsis invicta]
          Length = 545

 Score =  479 bits (1232), Expect = e-133
 Identities = 248/477 (51%), Positives = 326/477 (68%), Gaps = 9/477 (1%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLA +KEA   G KV VLDYV PS +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 61  YMYDLLVIGGGSGGLAAAKEAVGLGAKVAVLDYVTPSPLGTTWGLGGTCVNVGCIPKKLM 120

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ++L+GE++H D+ AFGW +  ++   DW  M   V +++KS+N+  +VELR KKV+Y 
Sbjct: 121 HQAALLGESLH-DAAAFGWQLDPKSIKNDWETMKNVVQNHVKSVNWVTRVELRTKKVEYF 179

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N LG F DAHT+     K   K +T ++++IAVGGRP+     G  +  ISSDDIF  + 
Sbjct: 180 NALGYFKDAHTVAGVSKKGDEKILTAKNIIIAVGGRPRYPDIPGALEYGISSDDIFSLER 239

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTLVVGA Y+ LECAGF+ G+GYD  ++VR+I+LRGFD+ MA  I E M+ +  + F
Sbjct: 240 APGKTLVVGAGYIGLECAGFLNGLGYDTTLIVRTIVLRGFDRQMAQHITEEMQ-QRGVNF 298

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           I     + + K E+G+LL  W   DG   ++ +DTVL A GR     +L  + AG+KL P
Sbjct: 299 IYEAKLKKVSKREDGRLLTDWVDKDGNVHQDVYDTVLFAIGRRSLTQELKPENAGLKLVP 358

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           +TG+I   NEQT+ PN+YA+GDV+   PELTPVAI AG+LLA+RL+ N T  MDY  V T
Sbjct: 359 ETGKIDAVNEQTNVPNIYAVGDVLHKKPELTPVAIHAGKLLAKRLFGNSTDKMDYTNVAT 418

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEEA++E  GED +EI+H  + P E+ +          CYVKV+  +
Sbjct: 419 TVFTPLEYGCVGLSEEAAVELHGEDQIEIFHAYYKPTEFFVPQKN---VDRCYVKVVALR 475

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             D+ V+G H++GPNAGEV Q    A+K G T   + + VGIHPT AE FT + +TK
Sbjct: 476 HHDEKVLGMHFIGPNAGEVIQGFAAAIKCGLTIPLLKSTVGIHPTVAEEFTRIFITK 532


>gb|ACH86016.1| thioredoxin glutathione reductase [Schistosoma japonicum]
          Length = 596

 Score =  479 bits (1232), Expect = e-133
 Identities = 246/485 (50%), Positives = 333/485 (68%), Gaps = 17/485 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA  KEAAKYG K+ VLDYV+P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIIIGGGSGGLAAGKEAAKYGAKIAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+ L+  ++ +D++ FGW++   E + DW+ M++ V S+I S+N+ YKV LRD  V Y 
Sbjct: 166 HQAGLLSHSL-EDAQHFGWSLDKSEISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAVTYL 224

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G  +  H +++    K   T+T   +++A   RPK     G  +  I+SDD+F    
Sbjct: 225 NARGMLLSPHEVQITEKNKKVSTITGNKIILATVERPKYPEIPGAIEYGITSDDLFSLPY 284

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVAL+CAGF+  +G DV +MVRSILLRGFDQ MA+K+G++ME    ++F
Sbjct: 285 FPGKTLVVGASYVALKCAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NHGVKF 343

Query: 239 IRGCVPQSIMKL-----EN---GQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLD 290
            + CVP  I +L     EN   G LLVK    DG+  EE F+TV+ A GR+P ++KL  +
Sbjct: 344 AKLCVPDEITQLKPVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKLNCE 403

Query: 291 KAGVKLNPKTGRIWVENEQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTL 349
             GVKL+     +  ++EQT+  N+YAIGD+    P+LTPVAI AGR LARRL+   T L
Sbjct: 404 AVGVKLDKNGRVVCSDDEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAGATEL 463

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
            DY  V T VFTP+EYG CGLSEE +IEK+G++++E+YH +F PLEW+++       + C
Sbjct: 464 TDYSNVATTVFTPLEYGACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVA---HREDNVC 520

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y+K++C  S +  V+G H LGPNAGE+TQ   +A+K+G T +     +GIHPT +E FTT
Sbjct: 521 YMKLVCRISDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHPTCSETFTT 580

Query: 470 LEVTK 474
           L VTK
Sbjct: 581 LHVTK 585


>ref|XP_002948663.1| NADPH-dependent thioredoxin reductase 1 [Volvox carteri f.
           nagariensis]
 gb|EFJ50043.1| NADPH-dependent thioredoxin reductase 1 [Volvox carteri f.
           nagariensis]
          Length = 511

 Score =  478 bits (1231), Expect = e-133
 Identities = 260/483 (53%), Positives = 332/483 (68%), Gaps = 14/483 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL+VIGGGSGGLAC+KEAAK GKKVC+LDYV PS  GT+WGLGGTCVNVGCIPKKL 
Sbjct: 20  YDWDLIVIGGGSGGLACAKEAAKLGKKVCLLDYVVPSPQGTTWGLGGTCVNVGCIPKKLF 79

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ+ L+GE    D++++GW + E    DW  ++  V S+I S+N+ Y+V LRD  VKY N
Sbjct: 80  HQAGLLGEGF-SDARSYGWKLPEGVDLDWEALVMGVQSHIGSLNWGYRVALRDASVKYLN 138

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G FID HT+E    + GTKT +T   +VIAVGGRPK L   G  +L ++SDDIF R  
Sbjct: 139 AKGHFIDPHTVEAVE-RNGTKTSLTAERIVIAVGGRPKFLGVPGDQELCLTSDDIFSRTT 197

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASY+ALECAGF+  +G+ V +M RSI LRGFDQ++A+ IG  +E    +  
Sbjct: 198 KPGKTLVVGASYIALECAGFLHALGFPVAVMARSIFLRGFDQEIAEMIGRDLE-RRGVRI 256

Query: 239 IRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +R  VP +  + +  Q+   +   D G    E+FDTVL A GRD   + LGLD+AGV ++
Sbjct: 257 LRPAVPTAFER-DGEQVRCTFKNLDFGLEMSESFDTVLLAVGRDACTSDLGLDRAGVTVD 315

Query: 298 PKTGRIWVENEQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
           P++G+I V  EQT+ P +YAIGDV++   ELTPVAI+AG  LARRLY   T  MDYD V 
Sbjct: 316 PRSGKIPVVAEQTNVPWIYAIGDVLENRQELTPVAIKAGVRLARRLYGAATLQMDYDAVP 375

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAA-----SSCYV 411
           T VFTP+EYGC G SEEA+  K+GEDN+E+Y     PLEW+++            +S Y 
Sbjct: 376 TTVFTPLEYGCVGYSEEAATAKYGEDNVEVYVSYLKPLEWTMNHEEHNGQPVREDNSVYC 435

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+I +KS ++ VVG HYLGPNAGE+ Q M +A+K G T     + +GIHPT AE FT LE
Sbjct: 436 KLITNKSDNERVVGVHYLGPNAGEIIQGMAVAIKAGATKADFDDCIGIHPTVAEEFTILE 495

Query: 472 VTK 474
           VTK
Sbjct: 496 VTK 498


>sp|B9A1H3|TRXR1_EMIHU RecName: Full=Thioredoxin reductase SEP1; Short=EhSEP1
 dbj|BAH20464.1| thioredoxin reductase [Emiliania huxleyi]
          Length = 495

 Score =  478 bits (1231), Expect = e-133
 Identities = 250/481 (51%), Positives = 318/481 (66%), Gaps = 16/481 (3%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLACSK AA +GKKV V D+VKPS  GT+WGLGGTCVNVGCIPKKLMHQ
Sbjct: 8   YDLLVIGGGSGGLACSKRAASHGKKVAVCDFVKPSPPGTTWGLGGTCVNVGCIPKKLMHQ 67

Query: 64  SSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLLG 123
           ++L+GE +  D+++FGW V     +W  M+ +V  +IKS+NF Y+ +L    VKY N   
Sbjct: 68  AALLGEGM-TDAESFGWEVAAPKHNWETMVGNVQGHIKSLNFGYRSDLMSNGVKYYNAYA 126

Query: 124 SFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEAPGK 182
           +F+D HT+E    K     +T  ++VI  GGRP+     G  +L I+SDD+F  K  PG+
Sbjct: 127 TFLDPHTVEAVDKKGKVTKITASEIVICTGGRPRYPDIPGAKELGITSDDVFALKSPPGR 186

Query: 183 TLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIRGC 242
           TLVVGASYVALECAGF+KG+GYD  +M+RSI LRGFDQ MA     +M+ E  + FI G 
Sbjct: 187 TLVVGASYVALECAGFIKGVGYDTTVMMRSIPLRGFDQQMAGLCKTYMQ-EHGVAFIEGA 245

Query: 243 VPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPKTGR 302
           VP ++    +G   V W  ADG      +DTVL A GRD   + +G+DKAGVKL+   G+
Sbjct: 246 VPTAVEATPSGAKKVSWKLADGSVGSGEYDTVLFAIGRDVCTSAIGIDKAGVKLS-SNGK 304

Query: 303 IWVENEQTSTPNVYAIGDVID---------APELTPVAIQAGRLLARRLYNNETTLMDYD 353
           +   NEQT+ P++YAIGD+ID           ELTPVAIQAG+LLA RLY  ++ LMDY 
Sbjct: 305 VPTVNEQTNVPHIYAIGDIIDGEALNPPSATTELTPVAIQAGKLLADRLYAGKSALMDYS 364

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T V+TP+EYG  GL EE +I+  GEDN+E+YH  F PLEW+L        + CY K+
Sbjct: 365 MVATTVYTPLEYGAVGLPEEEAIKLHGEDNIEVYHSYFKPLEWTL---PHRGDNVCYAKL 421

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC K   + V+G H  GPNAGE+TQ   +A+K G T     + VGIHPT AE FT L  T
Sbjct: 422 ICLKPEGERVIGLHVCGPNAGEMTQGFAVAIKAGATKAHFDDTVGIHPTVAEEFTLLAAT 481

Query: 474 K 474
           K
Sbjct: 482 K 482


>ref|XP_002154390.1| PREDICTED: similar to MGC81848 protein [Hydra magnipapillata]
          Length = 591

 Score =  478 bits (1231), Expect = e-133
 Identities = 253/481 (52%), Positives = 327/481 (67%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL VIGGGSGGLACSKEAA  G KV V D+V PS  G++WGLGGTCVNVGCIPKKLM
Sbjct: 105 YDFDLFVIGGGSGGLACSKEAADLGAKVAVADFVVPSPAGSTWGLGGTCVNVGCIPKKLM 164

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+GE IH DS+ +GW + E  + DWA+M+ ++  +I+S+N+ YKV LR K VKY N
Sbjct: 165 HQAALLGEAIH-DSRHYGWNIEENISHDWAKMVDAIQQHIRSLNWGYKVNLRQKNVKYYN 223

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
           +  +F+D HTL+L       +TVT    V+A GGRP      G  + AI+SDDIF     
Sbjct: 224 MYATFLDNHTLQLTDKSGKVETVTADKFVLATGGRPTYPDIPGAKECAITSDDIFSLPYV 283

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGK L  GASY+ALECAGF  G+G D  +M+RSI LRGFDQ MA+K+ ++ME    I+F+
Sbjct: 284 PGKVLFCGASYIALECAGFTHGIGMDTTVMMRSIPLRGFDQFMANKVVDYMETIG-IKFL 342

Query: 240 RGCVPQSIMKLENGQL-LVKWTTADGEACEE---AFDTVLNATGRDPDVAKLGLDKAGVK 295
           +   P  + K+E G    +K T  +    EE    F+TV+ A GR P    LGL+  GVK
Sbjct: 343 KKYTPIKMEKVEEGTPGKIKVTYMNHNTNEEESDIFNTVVVAIGRSPCTKGLGLENLGVK 402

Query: 296 LNPKTG-RIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYD 353
           LNP  G  I  E ++T+  N+Y IGD++D  PELTPVAIQAG+LLA+RL+N      DY 
Sbjct: 403 LNPLNGFLISDEYDRTNIENIYGIGDILDGKPELTPVAIQAGKLLAKRLFNGSKVTCDYT 462

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYG CGLSEE +IEK+GEDN+E+YH NFTPLE   ++      + CY KV
Sbjct: 463 NVATTVFTPLEYGACGLSEETAIEKYGEDNIEVYHSNFTPLE---ATVPHRLDNVCYAKV 519

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  ++ ++G H LGPNAGE+ Q   +A K+G     + +++GIHPT AEIFTTLE T
Sbjct: 520 ICNKKDEERILGMHVLGPNAGEIIQGFSIAFKVGAKKQHLDDLIGIHPTNAEIFTTLEKT 579

Query: 474 K 474
           K
Sbjct: 580 K 580


>ref|XP_002071893.1| GK24920 [Drosophila willistoni]
 gb|EDW82879.1| GK24920 [Drosophila willistoni]
          Length = 550

 Score =  478 bits (1230), Expect = e-133
 Identities = 254/478 (53%), Positives = 336/478 (70%), Gaps = 13/478 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGS GLAC+KEA   G +V  LD+VKP+ +GT WG+GGTCVNVGCIPKKLM
Sbjct: 68  YDYDLVVIGGGSAGLACAKEAVTNGARVACLDFVKPTPIGTKWGVGGTCVNVGCIPKKLM 127

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ+SL+GE +H ++ A+GW V ++   DW++++ SV ++IKS+N+  +V+LRDKKV+Y N
Sbjct: 128 HQASLLGEAVH-EAAAYGWNVDDKIKPDWSKLVSSVQNHIKSVNWVTRVDLRDKKVEYIN 186

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
            LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F     
Sbjct: 187 GLGSFVDSHTL-LAKLKSGERTITAQSFVIAVGGRPRYPEIPGAVEYGITSDDLFSLDHE 245

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I F+
Sbjct: 246 PGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIPFL 304

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           R  VP S+ K E+G+LLVK+  T  GE  E+ FDTVL A GR   V  L L  AGV ++ 
Sbjct: 305 RKTVPLSVEKQEDGRLLVKYENTETGEVSEDVFDTVLWAIGRKGLVDDLNLPNAGVLVH- 363

Query: 299 KTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
              +I V++ E T+  ++YA+GD+I   PELTPVA+ AGRLLARRL+ N T  MDY  V 
Sbjct: 364 -KDKIQVDSLETTNVGHIYAVGDIIYGKPELTPVAVLAGRLLARRLFANATQRMDYADVA 422

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EY C GLSEE +I+ +GE+ +E+YH  + P E+ +    + +   CYVK + +
Sbjct: 423 TTVFTPLEYACVGLSEEDAIKTYGEEEVEVYHGYYKPTEFFI---PQKSVRYCYVKAVAE 479

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           ++  + V G HYLGP+AGEV Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 480 RNGQQRVYGLHYLGPSAGEVIQGFAAALKSGLTVHTLMNTVGIHPTTAEEFTRLSITK 537


>ref|XP_001662666.1| thioredoxin reductase [Aedes aegypti]
 gb|EAT45854.1| thioredoxin reductase [Aedes aegypti]
          Length = 521

 Score =  478 bits (1229), Expect = e-132
 Identities = 258/484 (53%), Positives = 333/484 (68%), Gaps = 19/484 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVVIGGGSGGLAC+KEA ++G KV VLD+VKPS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 33  FDYDLVVIGGGSGGLACAKEAVQFGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLM 92

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ---TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE IH D++ +GW   E      DWA + +SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 93  HQASLLGEAIH-DAQPYGWKFAEPESVKHDWATLTESVQNHIKSVNWVTRVDLRDKKVEY 151

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK----PLACEGGDLAISSDDIF 174
            N LG F DAH +      +  + + T++VVIAVGGRP+    P A E G   I+SDDIF
Sbjct: 152 VNGLGYFKDAHNVVAVMKNQTERVLNTKNVVIAVGGRPRYPNIPGALEHG---ITSDDIF 208

Query: 175 WRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVES 234
                PGKTLVVGA Y+ LECAGF+KG GYD  +MVRSILLRGFDQ MA  +G+ M VE 
Sbjct: 209 SLPHEPGKTLVVGAGYIGLECAGFLKGFGYDATVMVRSILLRGFDQQMATMVGDAM-VEK 267

Query: 235 KIEFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
            I+F+    PQS+ K  +G+LLVK+ + DG    + +DTVL A GR      L LD+AGV
Sbjct: 268 GIKFLHKTQPQSVEKQADGRLLVKYRSDDGTEGSDVYDTVLFAIGRTACTDDLKLDQAGV 327

Query: 295 KL--NPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLM 350
                 K+ ++ V++ E T+ PN++A+GDV+   PELTPVAI AGRLLARRL+NN+T +M
Sbjct: 328 VTAEGGKSDKLDVDSFETTNVPNIFAVGDVLYKRPELTPVAIHAGRLLARRLFNNQTDIM 387

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DY  V T VF+P+EYGC G+SEE +  KFG+D +E+YH  + P E+ +    + +   CY
Sbjct: 388 DYADVATTVFSPLEYGCVGMSEENAEAKFGKDKVEVYHAYYKPTEFFV---PQRSVRYCY 444

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
           +K +     D+ V+G H+LGP AGEV Q    A+K G T   + N VGIHPT AE FT L
Sbjct: 445 LKAVALLEGDQKVLGLHFLGPVAGEVIQGFAAALKSGLTMKILKNTVGIHPTVAEEFTRL 504

Query: 471 EVTK 474
            +TK
Sbjct: 505 LITK 508


>ref|XP_001662665.1| thioredoxin reductase [Aedes aegypti]
 gb|EAT45853.1| thioredoxin reductase [Aedes aegypti]
          Length = 497

 Score =  478 bits (1229), Expect = e-132
 Identities = 258/484 (53%), Positives = 333/484 (68%), Gaps = 19/484 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVVIGGGSGGLAC+KEA ++G KV VLD+VKPS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 9   FDYDLVVIGGGSGGLACAKEAVQFGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLM 68

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ---TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE IH D++ +GW   E      DWA + +SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 69  HQASLLGEAIH-DAQPYGWKFAEPESVKHDWATLTESVQNHIKSVNWVTRVDLRDKKVEY 127

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK----PLACEGGDLAISSDDIF 174
            N LG F DAH +      +  + + T++VVIAVGGRP+    P A E G   I+SDDIF
Sbjct: 128 VNGLGYFKDAHNVVAVMKNQTERVLNTKNVVIAVGGRPRYPNIPGALEHG---ITSDDIF 184

Query: 175 WRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVES 234
                PGKTLVVGA Y+ LECAGF+KG GYD  +MVRSILLRGFDQ MA  +G+ M VE 
Sbjct: 185 SLPHEPGKTLVVGAGYIGLECAGFLKGFGYDATVMVRSILLRGFDQQMATMVGDAM-VEK 243

Query: 235 KIEFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
            I+F+    PQS+ K  +G+LLVK+ + DG    + +DTVL A GR      L LD+AGV
Sbjct: 244 GIKFLHKTQPQSVEKQADGRLLVKYRSDDGTEGSDVYDTVLFAIGRTACTDDLKLDQAGV 303

Query: 295 KL--NPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLM 350
                 K+ ++ V++ E T+ PN++A+GDV+   PELTPVAI AGRLLARRL+NN+T +M
Sbjct: 304 VTAEGGKSDKLDVDSFETTNVPNIFAVGDVLYKRPELTPVAIHAGRLLARRLFNNQTDIM 363

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DY  V T VF+P+EYGC G+SEE +  KFG+D +E+YH  + P E+ +    + +   CY
Sbjct: 364 DYADVATTVFSPLEYGCVGMSEENAEAKFGKDKVEVYHAYYKPTEFFV---PQRSVRYCY 420

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
           +K +     D+ V+G H+LGP AGEV Q    A+K G T   + N VGIHPT AE FT L
Sbjct: 421 LKAVALLEGDQKVLGLHFLGPVAGEVIQGFAAALKSGLTMKILKNTVGIHPTVAEEFTRL 480

Query: 471 EVTK 474
            +TK
Sbjct: 481 LITK 484


>ref|XP_001488273.1| PREDICTED: similar to TXNRD2 protein [Equus caballus]
          Length = 489

 Score =  476 bits (1224), Expect = e-132
 Identities = 249/478 (52%), Positives = 335/478 (70%), Gaps = 13/478 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA+ GKKV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 7   YDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVEPSPRGTRWGLGGTCVNVGCIPKKLMHQ 66

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V      DW +M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 67  AALLGGMI-RDAPHYGWEVPPLVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 125

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEA 179
            SF++ H +     K G +T+ + + +VIA GGRP+ P   EG  +  I+SDDIFW KE+
Sbjct: 126 ASFVNEH-MVCGVTKDGKETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDIFWLKES 184

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G D  +MVRSI LRGFDQ M+  + E+M       F+
Sbjct: 185 PGKTLVVGASYVALECAGFLTGLGLDATVMVRSIPLRGFDQQMSSLVTEYM-ASHGTRFL 243

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           RGC P  + +L +GQL V W   A G+     FDTVL A GR P+   L L+ AGV  +P
Sbjct: 244 RGCTPSRVGRLPDGQLQVTWEDLASGKKDVGTFDTVLWAIGRVPETRSLHLENAGVNTHP 303

Query: 299 KTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
            + +I V+  E TS P++YAIGDV +  PELTP A+ AG+LLARRL    + LMDYD V 
Sbjct: 304 NSQKILVDAGEATSVPHIYAIGDVAEGRPELTPPAVMAGKLLARRLCGQSSDLMDYDNVP 363

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EYGC GLSEE ++ + GE+++E+YH  + PLE++++      AS CY+K++C 
Sbjct: 364 TTVFTPLEYGCVGLSEEKAVARHGEEHVEVYHAYYKPLEFTVAERD---ASQCYIKMVCL 420

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  +GIHPT AE    L +TK
Sbjct: 421 REPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTLGIHPTCAEEVAKLRITK 478


>gb|EDL77943.1| thioredoxin reductase 2, isoform CRA_a [Rattus norvegicus]
          Length = 524

 Score =  476 bits (1224), Expect = e-132
 Identities = 244/478 (51%), Positives = 334/478 (69%), Gaps = 11/478 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL+VIGGGSGGLAC+KEAA+ G+KV V DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 41  NFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 100

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D++ +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 101 QAALLGGMI-RDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 159

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEA 179
             SF++ HT+           ++ + +VIA GGRPK P   +G  +  I+SDDIFW KE+
Sbjct: 160 KASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKES 219

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G D  +M+RS+ LRGFDQ MA  + E ME      F+
Sbjct: 220 PGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHG-TRFL 278

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           +GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAGV  NP
Sbjct: 279 KGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNP 338

Query: 299 KTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
           K  +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLM+Y  V 
Sbjct: 339 KNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVP 398

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C 
Sbjct: 399 TTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRD---ASQCYIKMVCM 455

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +   + V+G H+LGPNAGEVTQ   L ++ G +Y Q++  VGIHPT +E    L ++K
Sbjct: 456 REPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISK 513


>ref|NP_072106.1| thioredoxin reductase 2, mitochondrial precursor [Rattus
           norvegicus]
 sp|Q9Z0J5|TRXR2_RAT RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Thioredoxin reductase TR3; Flags: Precursor
 gb|AAD13801.1| thioredoxin reductase [Rattus norvegicus]
 gb|AAH85734.1| Thioredoxin reductase 2 [Rattus norvegicus]
          Length = 526

 Score =  476 bits (1224), Expect = e-132
 Identities = 244/478 (51%), Positives = 334/478 (69%), Gaps = 11/478 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL+VIGGGSGGLAC+KEAA+ G+KV V DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 41  NFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 100

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D++ +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 101 QAALLGGMI-RDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 159

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEA 179
             SF++ HT+           ++ + +VIA GGRPK P   +G  +  I+SDDIFW KE+
Sbjct: 160 KASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKES 219

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G D  +M+RS+ LRGFDQ MA  + E ME      F+
Sbjct: 220 PGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHG-TRFL 278

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           +GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAGV  NP
Sbjct: 279 KGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNP 338

Query: 299 KTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
           K  +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLM+Y  V 
Sbjct: 339 KNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVP 398

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EYGC GLSEE ++   G++++E+YH  + PLE++++      AS CY+K++C 
Sbjct: 399 TTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRD---ASQCYIKMVCM 455

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +   + V+G H+LGPNAGEVTQ   L ++ G +Y Q++  VGIHPT +E    L ++K
Sbjct: 456 REPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISK 513


>ref|XP_002734086.1| PREDICTED: thioredoxin reductase 1-like [Saccoglossus kowalevskii]
          Length = 600

 Score =  475 bits (1222), Expect = e-132
 Identities = 251/482 (52%), Positives = 338/482 (70%), Gaps = 14/482 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLA SK+AA++G+KV V D+VKP+  GT+WGLGGTCVNVGCIPKKL
Sbjct: 114 SYDYDLIVIGGGSGGLAASKKAAEHGQKVAVFDFVKPTPKGTTWGLGGTCVNVGCIPKKL 173

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G ++ +D+K +GW   ++ + +W  M  ++ ++I S+N+ Y+V+LRDK V Y 
Sbjct: 174 MHQAALLGHSL-EDAKKYGWEFDDKASHNWTTMRDAIQNHIGSLNWGYRVDLRDKNVTYH 232

Query: 120 NLLGSFIDAHTLELWHPKKGTKTV-TTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N    F D HT++  + KKG +TV T +  +IAVGGRP+     G  +  I+SDD+F   
Sbjct: 233 NAYAEFTDPHTVKAVN-KKGKETVMTAKRFIIAVGGRPRYPDIPGAKEYCITSDDLFSLP 291

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLV+GASYVALECAGF+ G+GYD  +MVRSILLRGFDQDMA++IG++ME    ++
Sbjct: 292 YNPGKTLVIGASYVALECAGFLAGIGYDTTVMVRSILLRGFDQDMANRIGDYMETHG-VK 350

Query: 238 FIRGCVPQSIMKLEN---GQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           FI+  +P  + +LE    G+L V +  T  GE      +TV+ A GRD     +GLDKAG
Sbjct: 351 FIKEHIPTMVEQLEEGSPGKLRVSYKATNGGEIKTIECNTVIIAVGRDACTQTIGLDKAG 410

Query: 294 VKLNPKTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDY 352
           V+ N K G+I  + E+T+  ++YA+GDV++  PELTPVAIQAG LLA RLY       DY
Sbjct: 411 VEYNVKNGKIPAQFEETNVSHIYALGDVLEGKPELTPVAIQAGTLLANRLYGGHVARCDY 470

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EYGCCGLSEE +I K+G+  +E++H  F PLE +++   +   + CY K
Sbjct: 471 VNVPTTVFTPLEYGCCGLSEEDAINKYGDQLVEVFHTYFKPLEHTVA---QREDNVCYGK 527

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
           +IC +     VVGFH LGPNAGE+TQ  G+AMK G +   +   +GIHPT AEIFTTL V
Sbjct: 528 IICHRVDSNRVVGFHVLGPNAGEITQGYGVAMKCGLSKGLLDLSIGIHPTCAEIFTTLSV 587

Query: 473 TK 474
           TK
Sbjct: 588 TK 589


>ref|XP_001966148.1| GF19373 [Drosophila ananassae]
 gb|EDV38557.1| GF19373 [Drosophila ananassae]
          Length = 537

 Score =  474 bits (1221), Expect = e-131
 Identities = 252/480 (52%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LDYVKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 53  SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDYVKPTPTLGTKWGVGGTCVNVGCIPKK 112

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ ++GW V ++   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 113 LMHQASLLGEAVH-EAASYGWNVDDKIKPDWGKLVQSVQNHIKSVNWVTRVDLRDKKVEY 171

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDDIF   
Sbjct: 172 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDIFSLD 230

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 231 HEPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVASSME-ERGIP 289

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K E+G+LLVK+   + GE  E+ FDTVL A GR   V  L L  AGV  
Sbjct: 290 FLRKTVPLSVEKQEDGKLLVKFKNVETGEEAEDTFDTVLWAIGRKGLVDDLNLPNAGV-- 347

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           N +  +I V++++ T+  N+YA+GD+I   PELTPVAI AGRLLARRLY   T  MDY  
Sbjct: 348 NTQKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAILAGRLLARRLYGGATQRMDYAD 407

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE +++++G D +E++H  + P E+ +    + +   CY+K +
Sbjct: 408 VATTVFTPLEYACVGLSEEDAVKQYGADEVEVFHGYYKPTEFFI---PQKSVRYCYLKAV 464

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 465 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLNITK 524


>ref|XP_001696072.1| NADPH-dependent thioredoxin reductase 1 [Chlamydomonas reinhardtii]
 gb|EDP01021.1| NADPH-dependent thioredoxin reductase 1 [Chlamydomonas reinhardtii]
          Length = 505

 Score =  474 bits (1221), Expect = e-131
 Identities = 258/483 (53%), Positives = 333/483 (68%), Gaps = 14/483 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDLVVIGGGSGGLAC+KEAAK GKKVC+LDYV PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 14  YEYDLVVIGGGSGGLACAKEAAKLGKKVCLLDYVVPSPAGTSWGLGGTCVNVGCIPKKLM 73

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H + L+GE    D++ +GW + E+   +W  ++  V ++I S+N+ Y+V LR+  VKY N
Sbjct: 74  HNAGLLGEGF-SDARGYGWKLPEKIEMNWEDLVMGVQNHIGSLNWGYRVALREASVKYLN 132

Query: 121 LLGSFIDAHTLELWHPKKGTK-TVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             GSF+DAHT+E    + GTK T+T   VVIAVGGRPK L   G  +L I+SDDIF R  
Sbjct: 133 AKGSFVDAHTVEAVE-RNGTKHTLTAERVVIAVGGRPKYLGVPGDKELCITSDDIFSRAT 191

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASY+ALECAGF++ +GY+V +M RSI LRGFDQ++A+ IG+ ME    +  
Sbjct: 192 PPGKTLVVGASYIALECAGFLRALGYEVAVMARSIFLRGFDQEIAELIGKDME-RRGVRM 250

Query: 239 IRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           I+  VP +  + +  Q+   +   D G    E+FDTVL A GRD     LGL+K GV  +
Sbjct: 251 IKPAVPTAFER-DGEQIKCTFKNLDFGVEMSESFDTVLLAVGRDACTFDLGLEKVGVTYD 309

Query: 298 PKTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
             +G+I V  EQT+ P++YAIGDV+++  ELTPVAI+AG  LARRLY   T  MDYD V 
Sbjct: 310 KSSGKIPVTAEQTNVPSIYAIGDVLESRQELTPVAIKAGIRLARRLYAGATLQMDYDAVP 369

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR-----PAASSCYV 411
           T VFTP+EYGC G SEEA+  K+G DN+E+Y     PLEW+++          A +S +V
Sbjct: 370 TTVFTPLEYGCVGYSEEAATVKYGADNIEVYVSYLKPLEWTMNHEEHNGEPVRADNSVFV 429

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+I + + ++ VVG HYLGPNAGE+ Q + +A+K   T     + +GIHPT AE FT LE
Sbjct: 430 KLITNTADNERVVGAHYLGPNAGEIIQGVAVAVKANATKADFDDCIGIHPTVAEEFTILE 489

Query: 472 VTK 474
           VTK
Sbjct: 490 VTK 492


>ref|XP_001455671.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK88274.1| unnamed protein product [Paramecium tetraurelia]
          Length = 486

 Score =  474 bits (1220), Expect = e-131
 Identities = 255/477 (53%), Positives = 331/477 (69%), Gaps = 13/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL VIGGGSGGLAC+K+AAK G KV + D+VKPS +GT WGLGGTCVNVGCIPKKLMH 
Sbjct: 7   YDLFVIGGGSGGLACAKQAAKLGAKVALADFVKPSPLGTKWGLGGTCVNVGCIPKKLMHF 66

Query: 64  SSLIGETIHKDSKAFGW--TVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           ++ +GE  H   +A GW  T  +   +W +M+++VN++I+ +NF YK +L    VKY N 
Sbjct: 67  AATLGELRHDQVEA-GWVDTQVDSKHNWEKMVENVNNHIRKLNFGYKNQLMRGDVKYYNK 125

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEG-GDLAISSDDIFWRKEA 179
           L   IDA+T++L   K   +TVT ++++IAVGGRP  P        L I+SDD+FW +E 
Sbjct: 126 LAELIDANTIKLTDNKGQIETVTAKNILIAVGGRPSYPENIPNIQKLVITSDDLFWLQEN 185

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALEC GF+ G+G +V IMVRSILLRGFDQ++A+KIG +ME E  I FI
Sbjct: 186 PGKTLVVGASYVALECGGFLHGIGNEVAIMVRSILLRGFDQEIAEKIGLYME-EKGIRFI 244

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           RGCVP  I   E+ +  V W   +G+  EE FDTVL ATGR  D  KL L+K GV +N K
Sbjct: 245 RGCVPDMIEATEDNKRKVTW-IINGQKYEEIFDTVLVATGRISDTQKLNLEKVGVNMN-K 302

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            G+I    +++TS PN++AIGD ++  PELTP AI+ G+LLA RL+N  T LM Y+ V T
Sbjct: 303 NGKILCSADDKTSVPNIFAIGDCVEGRPELTPTAIKCGQLLANRLFNKATELMSYEFVAT 362

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC G SEE +I+KFGED + +YH  F PLEW+       +  SC+ K+I   
Sbjct: 363 TVFTPLEYGCIGYSEEDAIKKFGEDKITVYHSIFKPLEWNYFE--MHSGESCFAKLIV-L 419

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + ++ V+GFHYLGP+AGEVTQ   +AMK+G T +Q  + VGIHPT +E    +   K
Sbjct: 420 NDNRRVIGFHYLGPHAGEVTQGYAVAMKMGVTKEQFDSTVGIHPTCSEELVQVTAVK 476


>ref|XP_001354460.2| GA15270 [Drosophila pseudoobscura pseudoobscura]
 gb|EAL31513.2| GA15270 [Drosophila pseudoobscura pseudoobscura]
          Length = 490

 Score =  474 bits (1219), Expect = e-131
 Identities = 249/479 (51%), Positives = 332/479 (69%), Gaps = 13/479 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYDLVVIGGGS GLAC+KEA + G +V  LDYVKP+ +GT WG+GGTCVNVGCIPKKL
Sbjct: 7   TYDYDLVVIGGGSAGLACAKEAVQNGARVACLDYVKPTPIGTKWGVGGTCVNVGCIPKKL 66

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ+SL+GE +H ++ A+GW V ++   DW++++ SV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 67  MHQASLLGEAVH-EAAAYGWNVDDKIKPDWSKLVSSVQNHIKSVNWVTRVDLRDKKVEYI 125

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N LGSF+D HT+ +   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F    
Sbjct: 126 NGLGSFVDRHTM-VAKLKSGDRTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDH 184

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   M+ E  I F
Sbjct: 185 EPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVASSMD-ERGIPF 243

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +R  VP S+ K +NG+LLVK+  T  GE  E+ +DTVL A GR   V  L L  AGV   
Sbjct: 244 LRKTVPLSVTKQDNGKLLVKYKNTETGEEGEDTYDTVLWAVGRKGLVEDLNLSNAGV--T 301

Query: 298 PKTGRIWVE-NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
               +I V+  E T+  N++A+GD+I   PELTPVA+ AGRLLARRLY      MDY  V
Sbjct: 302 TFKDKIQVDTKEATNVANIFAVGDIIYGKPELTPVAVLAGRLLARRLYGGSNQRMDYSDV 361

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EY C GLSEE ++++ G D +E++H  + P E+ +    + +   CY+K + 
Sbjct: 362 ATTVFTPLEYACVGLSEEDAVKQHGADGVEVFHGYYKPTEFFI---PQKSVRYCYLKAVA 418

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +++ D+ V G HYLGP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 419 ERTGDQRVYGLHYLGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLSITK 477


>ref|XP_001425944.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK58546.1| unnamed protein product [Paramecium tetraurelia]
          Length = 486

 Score =  474 bits (1219), Expect = e-131
 Identities = 255/469 (54%), Positives = 327/469 (69%), Gaps = 13/469 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL VIGGGSGGLAC+K+AAK G KV + D+VKPS +GT WGLGGTCVNVGCIPKKLMH
Sbjct: 6   EFDLFVIGGGSGGLACAKQAAKLGAKVALADFVKPSPLGTKWGLGGTCVNVGCIPKKLMH 65

Query: 63  QSSLIGETIHKDSKAFGW--TVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
            +S +GE  H   +A GW  T  +   +W +M+++VN++I+ +NF YK +L    VKY N
Sbjct: 66  FASTLGELRHDQVEA-GWIDTQVDSKHNWEKMVENVNNHIRKLNFGYKNQLMRGDVKYYN 124

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEG-GDLAISSDDIFWRKE 178
            L   IDA+T++L   K   +TV  + +VIAVGGRP  P        L I+SDD+FW +E
Sbjct: 125 KLAELIDANTIKLTDNKGKIETVRAKTIVIAVGGRPSYPENIPNIQKLVITSDDLFWLQE 184

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALEC GF+ G+G +V IMVRSILLRGFDQ++A+KIG +ME E  I F
Sbjct: 185 NPGKTLVVGASYVALECGGFLHGIGNEVAIMVRSILLRGFDQEIAEKIGLYME-EKGIRF 243

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           IRGCVP  I   E+ +  V W   +G+  EE FDTVL ATGR  D  KL L+K GV LN 
Sbjct: 244 IRGCVPDMIEATEDNKRKVTW-ILNGQKYEEIFDTVLVATGRISDTQKLNLEKVGVNLN- 301

Query: 299 KTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
           K G+I    +++TS PN++AIGD ++  PELTP AI+ G+LLA RL+N    LM YD V 
Sbjct: 302 KNGKILCSADDKTSVPNIFAIGDCVEGRPELTPTAIKCGQLLANRLFNKANELMSYDYVA 361

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EYGC G SEE +I+KFGED + +YH  F PLEW+       +  SC+ K+I  
Sbjct: 362 TTVFTPLEYGCIGYSEEDAIKKFGEDKITVYHSIFKPLEWNYFE--MHSGESCFAKLIV- 418

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
            + ++ V+GFHYLGP+AGEVTQ   +AMK+G T +Q  + VGIHPT +E
Sbjct: 419 LNNNRRVIGFHYLGPHAGEVTQGYAVAMKMGVTKEQFDSTVGIHPTCSE 467


>gb|AAC69637.1| glutathione reductase family member [Musca domestica]
          Length = 495

 Score =  473 bits (1218), Expect = e-131
 Identities = 249/480 (51%), Positives = 335/480 (69%), Gaps = 14/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLAC+KEA   G KV  LDYVKP+ +GT WG+GGTCVNVGCIPKKLM
Sbjct: 10  YDYDLIVIGGGSGGLACAKEAVANGAKVACLDYVKPTPLGTKWGIGGTCVNVGCIPKKLM 69

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF---DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE+IH ++ A+GW +  +      W  ++++V ++IKS+N+  +V+LRDKKV+Y
Sbjct: 70  HQASLLGESIH-EATAYGWEIPNKEAIKPKWENLVQAVQNHIKSVNWVTRVDLRDKKVEY 128

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N  GSF D HT+         +T+T R+VVIAVGGRP+     G  +  I+SDD+F   
Sbjct: 129 INGAGSFKDPHTVVAKMKNGSERTLTGRNVVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 188

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           + PGKTLVVGA Y+ LECAGF+KG+GYD  +MVRSI+LRGFDQ MA+ + + M VE  I 
Sbjct: 189 KEPGKTLVVGAGYIGLECAGFLKGLGYDATVMVRSIVLRGFDQQMANMVADSM-VERGIP 247

Query: 238 FIRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+   +P+S+ K ++G+LLVK+  T   E   + +DTVL A GR   V  L L  AG+++
Sbjct: 248 FLHKTIPKSVEKTQDGRLLVKYVNTETQEEGSDVYDTVLWAIGRKGLVDDLNLGAAGIEV 307

Query: 297 NPKTGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             K  +I V E EQT+ P+++A+GD+I   PELTPVAI AGRLLARRL+     +MDY  
Sbjct: 308 --KADKIAVNEAEQTNVPHIFAVGDIIHGRPELTPVAIHAGRLLARRLFGGSKQIMDYTD 365

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VF+P+EY C G++EE +I+KFGEDN+E++H  + P E+ +    + +   CYVK +
Sbjct: 366 VATTVFSPLEYACVGMAEEDAIQKFGEDNIEVFHGFYKPTEFFI---PQKSVRYCYVKAV 422

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++S D+ V+G HYLGP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 423 AERSGDQKVLGLHYLGPVAGEVIQGFAAAVKSGLTMKILLNTVGIHPTTAEEFTRLAITK 482


>ref|NP_001177260.1| thioredoxin reductase 3 [Ciona intestinalis]
          Length = 623

 Score =  473 bits (1217), Expect = e-131
 Identities = 255/483 (52%), Positives = 336/483 (69%), Gaps = 17/483 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDL+VIGGGSGGLA SK A++ GKKV V D+V+P+  G SWGLGGTCVNVGCIPKKLM
Sbjct: 135 YEYDLIVIGGGSGGLAASKRASELGKKVAVCDFVQPTPKGVSWGLGGTCVNVGCIPKKLM 194

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+S++G++I +D+K+FGW +  +     W  M+++V +YI S+N+ Y+V+LR+KKV Y 
Sbjct: 195 HQASMLGKSI-EDAKSFGWQLTSEPVKNKWEGMVEAVQNYIGSLNWGYRVQLREKKVNYV 253

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N    F D HT+   + ++G +T  T D  ++AVG RP+     G  +  I+SDD+F   
Sbjct: 254 NAYAKFEDQHTITTVN-RRGKETKMTADKFIVAVGERPRYPDIPGAKEHCITSDDLFSLP 312

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLV+GASYVALECAGF+KG+G DV +MVRSI LRGFDQ MADK   +ME E  ++
Sbjct: 313 YCPGKTLVIGASYVALECAGFLKGIGLDVTVMVRSIFLRGFDQQMADKAAGYMEKEG-VQ 371

Query: 238 FIRGCVPQSIMKLENGQL-LVKWT---TADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           F+R CVP  I ++E G+  L++ T   T +GE     ++TV+ A GRD     +GLDK  
Sbjct: 372 FLRRCVPVKIEQVEAGEPGLLRVTGKMTENGEEVTGDYNTVILAIGRDSVTKTIGLDKIN 431

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMD 351
           V+++ K G++ V + +QT+  N++ IGD  +  PELTPVAI AGRLL+ RLY   T   D
Sbjct: 432 VQVS-KNGKVPVNDYDQTNVENIFCIGDNGEGKPELTPVAIHAGRLLSERLYGGSTLKCD 490

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y+ V T VFTP+EY CCGLSEEA+I K+GEDNLE+YH N  PLEWS+        ++CYV
Sbjct: 491 YEGVPTTVFTPLEYSCCGLSEEAAIAKYGEDNLEVYHTNVWPLEWSVPGHDN---NTCYV 547

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K I +K   + V+G HYLGPNAGEV Q    AMK G T  Q+   +GIHPTTAE+FTTL 
Sbjct: 548 KAITNKLDSERVIGLHYLGPNAGEVMQGFAAAMKCGITKAQLDQTIGIHPTTAELFTTLN 607

Query: 472 VTK 474
           VTK
Sbjct: 608 VTK 610


>gb|EFB13457.1| hypothetical protein PANDA_003518 [Ailuropoda melanoleuca]
          Length = 539

 Score =  473 bits (1216), Expect = e-131
 Identities = 249/475 (52%), Positives = 329/475 (69%), Gaps = 17/475 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEA--AKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKK 59
           YDYDL+++GGGSGGLA +K    +KY KK+ VLD+V P+  GT WGLGGTCVNVGCIPKK
Sbjct: 71  YDYDLIIVGGGSGGLAAAKARLLSKYDKKIMVLDFVTPTPHGTRWGLGGTCVNVGCIPKK 130

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ++L+G+ + +DS+ +GW   E    DW +M ++V ++I S+N+ Y+V LR+KKV Y
Sbjct: 131 LMHQAALLGQAL-RDSRNYGWDTEETVKHDWNKMTEAVQNHIGSLNWGYRVALREKKVTY 189

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           EN  G F+  H ++  + K   K  +    +IA G RP+ L   G  +  ISSDD+F   
Sbjct: 190 ENAYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDREYCISSDDLFSLP 249

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  ++
Sbjct: 250 YCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGVK 308

Query: 238 FIRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKA 292
           FI+  VP  + ++E G     +++ K T++D E  E  ++TVL A GRD    K+GL+  
Sbjct: 309 FIKQFVPIKVEQIEAGTPGRLRVVAKSTSSD-ETIEGEYNTVLLAIGRDACTRKIGLETV 367

Query: 293 GVKLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLM 350
           GVK+N K G+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       
Sbjct: 368 GVKINEKNGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYAGSNVKC 427

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DY+ V T VFTP+EYG CGLSEE ++E FGE+N+E+YH  F PLEW++ S      + CY
Sbjct: 428 DYENVPTTVFTPLEYGACGLSEEKAVETFGEENIEVYHSFFWPLEWTIPSRDN---NKCY 484

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
            K+IC+   ++ VVGFH LGPNAGEVTQ    A+K G T  Q+ + +GIHP  AE
Sbjct: 485 AKIICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAE 539


>ref|XP_001847793.1| thioredoxin reductase 1, mitochondrial [Culex quinquefasciatus]
 gb|EDS26956.1| thioredoxin reductase 1, mitochondrial [Culex quinquefasciatus]
          Length = 536

 Score =  473 bits (1216), Expect = e-131
 Identities = 254/481 (52%), Positives = 330/481 (68%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLAC+KEA ++G KV VLD+V PS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 48  YDYDLVVIGGGSGGLACAKEAIQFGAKVAVLDFVVPSPRGTKWGLGGTCVNVGCIPKKLM 107

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT---FDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE IH DS+ +GW   E      DWA + +SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 108 HQASLLGEAIH-DSQPYGWKFAEPASVKHDWATLTESVQNHIKSVNWVTRVDLRDKKVEY 166

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRK 177
            N  G F DAH +      K  + ++T+ VVIAVGGRP+ P      +  I+SDDIF   
Sbjct: 167 VNGFGYFKDAHNVVAVMKNKTERVLSTKYVVIAVGGRPRYPNIPGAEEYGITSDDIFSLP 226

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           + PGKTLVVGA Y+ LECAGF+KG+GYD  +MVRSILLRGFDQ MA  +G+ M VE  I+
Sbjct: 227 QEPGKTLVVGAGYIGLECAGFLKGLGYDATVMVRSILLRGFDQQMATMVGDAM-VEKGIK 285

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL- 296
           F+    P S+ K E+G+LLVK+ + +G    + +DTVL A GR      L LD+AG+   
Sbjct: 286 FMHKTQPTSVEKQEDGRLLVKYASDEGVEGSDVYDTVLFAIGRTACTKDLKLDQAGIVTA 345

Query: 297 -NPKTGRIWVE-NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYD 353
              K+ ++ V   EQT+  NV+A+GDV+   PELTPVAI AGRLLARRL+NN++ +MDY 
Sbjct: 346 EGNKSDKLDVTVQEQTNVDNVFAVGDVLYKKPELTPVAIHAGRLLARRLFNNQSDVMDYT 405

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VF+P+EYGC GLSEE +  K+G++N+E+YH  + P E+ +    + +   CY+K 
Sbjct: 406 DVATTVFSPLEYGCVGLSEEDAEAKYGKENVEVYHAYYKPTEFFV---PQRSVRYCYLKA 462

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           +     D+ V+G H+LGP AGEV Q    A+K G T   + N VGIHPT AE FT L +T
Sbjct: 463 VALLEGDQKVLGLHFLGPAAGEVIQGFAAAVKSGLTMKILKNTVGIHPTVAEEFTRLLIT 522

Query: 474 K 474
           K
Sbjct: 523 K 523


>ref|XP_002101164.1| GE15773 [Drosophila yakuba]
 gb|EDX02272.1| GE15773 [Drosophila yakuba]
          Length = 491

 Score =  472 bits (1214), Expect = e-131
 Identities = 249/480 (51%), Positives = 338/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LDYVKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDYVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V ++   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDDKIKPDWNKLVQSVQNHIKSVNWVTRVDLRDKKVEY 125

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F  +
Sbjct: 126 INGLGSFVDSHTL-LAKIKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLE 184

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 185 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 243

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ FDTVL A GR   V  L L  AGV +
Sbjct: 244 FLRKSVPLSVEKQDDGKLLVKYKNVETGEEAEDVFDTVLWAIGRKGLVDDLNLPNAGVTV 303

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 304 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGATQRMDYKD 361

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE +++++G D +E++H  + P E+ +    + +   CY+K +
Sbjct: 362 VATTVFTPLEYACVGLSEEDAVKEYGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 418

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 419 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 478


>ref|XP_001977919.1| GG19308 [Drosophila erecta]
 gb|EDV46846.1| GG19308 [Drosophila erecta]
          Length = 491

 Score =  472 bits (1214), Expect = e-131
 Identities = 249/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LDYVKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDYVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V E+   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVNEKIKPDWNKLVQSVQNHIKSVNWVTRVDLRDKKVEY 125

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 126 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 184

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 185 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 243

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   +  E  E+ FDTVL A GR   V  L L  AGV +
Sbjct: 244 FLRKSVPLSVQKQDDGKLLVKYKNVETDEEAEDVFDTVLWAIGRKGLVDDLNLPNAGVTV 303

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY+ 
Sbjct: 304 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGATQRMDYND 361

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE +++++G D +E++H  + P E+ +    + +   CY+K +
Sbjct: 362 VATTVFTPLEYACVGLSEEEAVKQYGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 418

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 419 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 478


>gb|AAG25640.1|AF301145_1 thioredoxin reductase-1 splice variant [Drosophila melanogaster]
          Length = 491

 Score =  471 bits (1212), Expect = e-130
 Identities = 249/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V E+   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 125

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 126 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 184

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 185 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 243

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ +DTVL A GR   V  L L  AGV +
Sbjct: 244 FLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV 303

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 304 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 361

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE ++++FG D +E++H  + P E+ +    + +   CY+K +
Sbjct: 362 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 418

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 419 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 478


>ref|NP_727251.1| thioredoxin reductase-1, isoform B [Drosophila melanogaster]
 sp|P91938|TRXR1_DROME RecName: Full=Thioredoxin reductase 1, mitochondrial; Short=TrxR-1;
           Flags: Precursor
 gb|AAF46355.2| thioredoxin reductase-1, isoform B [Drosophila melanogaster]
          Length = 596

 Score =  471 bits (1212), Expect = e-130
 Identities = 249/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 112 SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 171

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V E+   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 172 LMHQASLLGEAVH-EAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 230

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 231 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 289

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 290 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 348

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ +DTVL A GR   V  L L  AGV +
Sbjct: 349 FLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV 408

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 409 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 466

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE ++++FG D +E++H  + P E+ +    + +   CY+K +
Sbjct: 467 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 523

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 524 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 583


>ref|NP_511082.2| thioredoxin reductase-1, isoform A [Drosophila melanogaster]
 gb|AAG25639.1|AF301144_1 thioredoxin reductase-1 [Drosophila melanogaster]
 gb|AAF46354.1| thioredoxin reductase-1, isoform A [Drosophila melanogaster]
 gb|AAO25023.1| LD21729p [Drosophila melanogaster]
 gb|ACL84476.1| Trxr-1-PA [synthetic construct]
 gb|ACL89485.1| Trxr-1-PA [synthetic construct]
          Length = 491

 Score =  471 bits (1212), Expect = e-130
 Identities = 249/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V E+   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 125

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 126 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 184

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 185 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 243

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ +DTVL A GR   V  L L  AGV +
Sbjct: 244 FLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV 303

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 304 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 361

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE ++++FG D +E++H  + P E+ +    + +   CY+K +
Sbjct: 362 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 418

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 419 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 478


>ref|NP_727252.1| thioredoxin reductase-1, isoform C [Drosophila melanogaster]
 gb|AAN09228.1| thioredoxin reductase-1, isoform C [Drosophila melanogaster]
 gb|ABE73241.1| IP15366p [Drosophila melanogaster]
          Length = 508

 Score =  471 bits (1212), Expect = e-130
 Identities = 249/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 24  SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 83

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V E+   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 84  LMHQASLLGEAVH-EAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 142

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 143 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 201

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 202 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 260

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ +DTVL A GR   V  L L  AGV +
Sbjct: 261 FLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV 320

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 321 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 378

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE ++++FG D +E++H  + P E+ +    + +   CY+K +
Sbjct: 379 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 435

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 436 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 495


>gb|ADH94550.1| thioredoxin reductase 1 [Apis cerana cerana]
 gb|ADH94551.1| thioredoxin reductase 1 [Apis cerana cerana]
          Length = 494

 Score =  470 bits (1210), Expect = e-130
 Identities = 248/477 (51%), Positives = 328/477 (68%), Gaps = 12/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA  +G KV VLD+V PS  G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 11  YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 70

Query: 64  SSLIGETIHKDSKAFGWTVGEQTF---DWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           ++L+GE+IH DS ++GW + +      DW  +  +V +++KS+N+  +VELR KK++Y N
Sbjct: 71  AALLGESIH-DSVSYGWQLPDPKTIKNDWQALRTAVQNHVKSVNWVTRVELRTKKIEYFN 129

Query: 121 LLGSFIDAHTLELWHPKKG-TKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
            LG F D HT+ L   K G  K  T ++++IAVGGRP+     G  +  I+SDDIF  ++
Sbjct: 130 ALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSLEK 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTL+VGA Y+ LECAGF+ G+GYD  +MVRSI+LRGFDQ MA  + + ME    I F
Sbjct: 189 APGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRGIHF 247

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           I    P  I K  +G+LLV W   D +  ++ FDTVL A GR P   +L  +  G+KL P
Sbjct: 248 IYEAKPSKIEKQTDGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLKLVP 307

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           +T +I   +EQT+ PNVYA+GDV+   PELTPVAI AGRLLARRL+ N T  MDY  V T
Sbjct: 308 ETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVNVAT 367

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VF+P+EYGC GLSEEA+I   G+D +EIYH  + P E+ +    +   S+CY+KVI  +
Sbjct: 368 TVFSPLEYGCVGLSEEAAIAIHGDDKIEIYHAYYKPTEFFI---PQKDVSNCYLKVIAFR 424

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + D+ V+G H++GPNAGEV Q    A+K   T+ ++ + VGIHPT AE FT + VTK
Sbjct: 425 NGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHPTVAEEFTRISVTK 481


>ref|XP_002722800.1| PREDICTED: thioredoxin reductase 2-like [Oryctolagus cuniculus]
          Length = 491

 Score =  470 bits (1210), Expect = e-130
 Identities = 242/478 (50%), Positives = 336/478 (70%), Gaps = 13/478 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA+ G+KV VLDYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 9   YDLLVIGGGSGGLACAKEAAQLGRKVAVLDYVEPSPRGTRWGLGGTCVNVGCIPKKLMHQ 68

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    DW++M +++ ++++S+N+ ++V+L+++KVKY N+ 
Sbjct: 69  AALLGGAI-RDAGRYGWEVAQPARHDWSKMAEAIQNHVRSLNWGHRVQLQERKVKYLNVK 127

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEG-GDLAISSDDIFWRKEA 179
             FID HT+ L   K   +T+ + D +VIA GGRP+ P   +G  +  I+SDDIFW KE+
Sbjct: 128 ARFIDKHTV-LGVSKDKKETLLSADHIVIATGGRPRYPTLIQGASEYGITSDDIFWLKES 186

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ MA  + + M        +
Sbjct: 187 PGKTLVVGASYVALECAGFLTGLGLDTTIMIRSIPLRGFDQQMASLVTDHM-ASHGTRIL 245

Query: 240 RGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           RGC P  + +L +G+L V W     G+     F+TVL A GR P+   L L+ AGV+ NP
Sbjct: 246 RGCTPSRVARLPDGRLQVTWEDRTCGKEDSGVFNTVLWAIGRVPETRGLNLEGAGVETNP 305

Query: 299 KTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
           ++ +I V+  + TS P++YAIGDV +  PELTP AI AG+LLA+RL+   + LMDY  V 
Sbjct: 306 ESQKILVDARDTTSVPHIYAIGDVAEGRPELTPTAIMAGKLLAQRLFGGSSDLMDYSNVP 365

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VFTP+EYGC GLSEE ++ + G++ +E+YH  + PLE++++      AS CY+K++C 
Sbjct: 366 TTVFTPLEYGCVGLSEEEAVARHGQEQIEVYHAYYKPLEFTVAEQD---ASQCYIKMVCL 422

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +   + V+G H+LGPNAGEVTQ   L +K G +Y+Q++  VGIHPT AE    L ++K
Sbjct: 423 RQPPQPVLGLHFLGPNAGEVTQGFALGIKCGASYEQVIRTVGIHPTCAEEMVKLRISK 480


>ref|XP_001991610.1| GH12753 [Drosophila grimshawi]
 gb|EDW00235.1| GH12753 [Drosophila grimshawi]
          Length = 596

 Score =  470 bits (1209), Expect = e-130
 Identities = 252/479 (52%), Positives = 328/479 (68%), Gaps = 13/479 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGLAC+KEA   G +V  LDYVKP+ +GT WG+GGTCVNVGCIPKKL
Sbjct: 113 SYDYDLVVIGGGSGGLACAKEAVANGARVACLDYVKPTPIGTKWGVGGTCVNVGCIPKKL 172

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ+SL+GE +H ++ A+GW V ++   DW +++ SV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 173 MHQASLLGEAVH-EAAAYGWNVDDKIKPDWKKLVSSVQNHIKSVNWVTRVDLRDKKVEYI 231

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N LGSF+D HTL     K G +T+T +  VIAVGGRP+     G  +  I+SDD+F    
Sbjct: 232 NGLGSFVDPHTLSA-KLKNGDRTITAQTFVIAVGGRPRYPNIPGAVEYGITSDDLFSLDR 290

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I F
Sbjct: 291 EPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAASME-ERGIPF 349

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +R  VP S+ K  +G+LLVK+  T  GE   + FDTVL A GR   V  L L  AGV  +
Sbjct: 350 LRRTVPLSVEKQPDGRLLVKYECTETGEIGSDVFDTVLWAVGRKGLVDDLNLPNAGVLAH 409

Query: 298 PKTGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
               +I V+ +E T+ P++YA+GD+I   PELTPVA+ AGRLLARRLY +    MDY  V
Sbjct: 410 --NDKIQVDCDEATNVPHIYAVGDIIHGKPELTPVAVLAGRLLARRLYADSDLRMDYADV 467

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EY C GLSEE +++  G D +E++H  + P E+ +    + +   CYVK + 
Sbjct: 468 ATTVFTPLEYACVGLSEEDAVKAHGADEIEVFHGYYKPTEFFI---PQKSVRYCYVKAVA 524

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +  D+ V G HYLGP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 525 QRHGDQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHPTTAEEFTRLSITK 583


>pdb|3DH9|A Chain A, Crystal Structure Of Drosophila Thioredoxin Reductase,
           Wild- Type
 pdb|3DH9|B Chain B, Crystal Structure Of Drosophila Thioredoxin Reductase,
           Wild- Type
          Length = 482

 Score =  469 bits (1208), Expect = e-130
 Identities = 248/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 3   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 62

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V ++   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 63  LMHQASLLGEAVH-EAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 121

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 122 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 180

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 181 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 239

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ +DTVL A GR   V  L L  AGV +
Sbjct: 240 FLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPNAGVTV 299

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 300 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 357

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE ++++FG D +E++H  + P E+ +    + +   CY+K +
Sbjct: 358 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 414

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 415 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 474


>pdb|3DGH|A Chain A, Crystal Structure Of Drosophila Thioredoxin Reductase, C-
           Terminal 8-Residue Truncation
 pdb|3DGH|B Chain B, Crystal Structure Of Drosophila Thioredoxin Reductase, C-
           Terminal 8-Residue Truncation
          Length = 483

 Score =  469 bits (1208), Expect = e-130
 Identities = 248/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V ++   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 125

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 126 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 184

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 185 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 243

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ +DTVL A GR   V  L L  AGV +
Sbjct: 244 FLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPNAGVTV 303

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 304 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 361

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE ++++FG D +E++H  + P E+ +    + +   CY+K +
Sbjct: 362 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 418

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 419 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 478


>ref|XP_001603220.1| PREDICTED: similar to thioredoxin reductase [Nasonia vitripennis]
          Length = 539

 Score =  469 bits (1208), Expect = e-130
 Identities = 246/478 (51%), Positives = 321/478 (67%), Gaps = 10/478 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y YDLVV+GGGSGGLA +K+A + G KV V DYV PS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 54  YQYDLVVLGGGSGGLAAAKQATELGAKVAVFDYVIPSPQGTKWGLGGTCVNVGCIPKKLM 113

Query: 62  HQSSLIGETIHKDSKAFGWTVGE---QTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ++L+GE +H ++ AFGW + E      DW  +  +V +++KS+N+  +VELR+KKV+Y
Sbjct: 114 HQAALLGEAVH-EATAFGWQIPEVKSVKIDWEALTTAVQNHVKSVNWVTRVELRNKKVEY 172

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LG F D HT+         K VT ++V+IAVGGRP      G  +  I+SDDIF   
Sbjct: 173 INALGYFKDPHTIGGIMKNGEEKVVTAKNVLIAVGGRPNYPDIPGAVEYGITSDDIFSLS 232

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           + PGKTLVVGA Y+ LECAGF+ G+GYD  IMVRSI+LRGFDQ MA+ I E ME    + 
Sbjct: 233 KPPGKTLVVGAGYIGLECAGFLNGLGYDATIMVRSIILRGFDQQMANIIAEEMETRG-VH 291

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           FI    P+++ K  +G +LV W   DG+  ++ +DTVL A GR      L L+ AGV + 
Sbjct: 292 FIYQAKPKALEKQADGSILVHWVDKDGQIHKDVYDTVLFAIGRKALTKDLKLENAGVFVV 351

Query: 298 PKTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
           P+  +I   NEQT+ P+VYA+GDV+   PELTPVAI AG+LLA+RLY N T LMDY  V 
Sbjct: 352 PENEKIDALNEQTNVPHVYAVGDVLHKKPELTPVAIHAGKLLAKRLYGNATELMDYTNVA 411

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T VF+P+EYGC GLSEE +I   GED++EIYH  + P E+ +        S CY+KV+  
Sbjct: 412 TTVFSPLEYGCVGLSEEQAIAIHGEDSIEIYHAYYKPTEFFVPQKDN---SRCYLKVVAL 468

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           ++ D+ V+G H++GPNAGEV Q    A+K   T+  + + VGIHPT AE FT + +TK
Sbjct: 469 RNNDQKVLGLHFVGPNAGEVIQGFATAIKCNLTFPLLKSTVGIHPTIAEEFTRVNITK 526


>pdb|2NVK|X Chain X, Crystal Structure Of Thioredoxin Reductase From Drosophila
           Melanogaster
          Length = 488

 Score =  469 bits (1208), Expect = e-130
 Identities = 248/480 (51%), Positives = 337/480 (70%), Gaps = 14/480 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPS-LVGTSWGLGGTCVNVGCIPKK 59
           +YDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+  +GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           LMHQ+SL+GE +H ++ A+GW V ++   DW ++++SV ++IKS+N+  +V+LRDKKV+Y
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 125

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LGSF+D+HTL L   K G +T+T +  VIAVGGRP+     G  +  I+SDD+F   
Sbjct: 126 INGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLD 184

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I 
Sbjct: 185 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-ERGIP 243

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+R  VP S+ K ++G+LLVK+   + GE  E+ +DTVL A GR   V  L L  AGV +
Sbjct: 244 FLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPNAGVTV 303

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +  +I V++++ T+  N+YA+GD+I   PELTPVA+ AGRLLARRLY   T  MDY  
Sbjct: 304 --QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 361

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C GLSEE ++++FG D +E++H  + P E+ +    + +   CY+K +
Sbjct: 362 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFI---PQKSVRYCYLKAV 418

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            ++  D+ V G HY+GP AGEV Q    A+K G T + ++N VGIHPTTAE FT L +TK
Sbjct: 419 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITK 478


>ref|NP_001171496.1| thioredoxin reductase 1 isoform 1 [Apis mellifera]
          Length = 537

 Score =  469 bits (1207), Expect = e-130
 Identities = 247/477 (51%), Positives = 327/477 (68%), Gaps = 12/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA  +G KV VLD+V PS  G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 54  YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 113

Query: 64  SSLIGETIHKDSKAFGWTVGEQTF---DWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           ++L+GE+IH DS ++GW + +      DW  +  +V +++KS+N+  +VELR KK++Y N
Sbjct: 114 AALLGESIH-DSVSYGWQLPDPKTIKNDWEALRTAVQNHVKSVNWVTRVELRTKKIEYFN 172

Query: 121 LLGSFIDAHTLELWHPKKG-TKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
            LG F D HT+ L   K G  K  T ++++IAVGGRP+     G  +  I+SDDIF  ++
Sbjct: 173 ALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSLEK 231

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTL+VGA Y+ LECAGF+ G+GYD  +MVRSI+LRGFDQ MA  + + ME    + F
Sbjct: 232 APGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRGVHF 290

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           I    P  I K  +G+LLV W   D +  ++ FDTVL A GR P   +L  +  G+KL P
Sbjct: 291 IYEAKPSKIEKQADGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLKLVP 350

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           +T +I   +EQT+ PNVYA+GDV+   PELTPVAI AGRLLARRL+ N T  MDY  V T
Sbjct: 351 ETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVNVAT 410

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VF+P+EYGC GLSEEA+I   G D +EIYH  + P E+ +    +   S+CY+KVI  +
Sbjct: 411 TVFSPLEYGCVGLSEEAAIAIHGNDKIEIYHAYYKPTEFFI---PQKDVSNCYLKVIAFR 467

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + D+ V+G H++GPNAGEV Q    A+K   T+ ++ + VGIHPT AE FT + VTK
Sbjct: 468 NGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHPTVAEEFTRISVTK 524


>gb|AAP93583.1| thioredoxin reductase [Apis mellifera ligustica]
          Length = 485

 Score =  469 bits (1207), Expect = e-130
 Identities = 247/477 (51%), Positives = 327/477 (68%), Gaps = 12/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA  +G KV VLD+V PS  G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 2   YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 61

Query: 64  SSLIGETIHKDSKAFGWTVGEQTF---DWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           ++L+GE+IH DS ++GW + +      DW  +  +V +++KS+N+  +VELR KK++Y N
Sbjct: 62  AALLGESIH-DSVSYGWQLPDPKTIKNDWEALRTAVQNHVKSVNWVTRVELRTKKIEYFN 120

Query: 121 LLGSFIDAHTLELWHPKKG-TKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
            LG F D HT+ L   K G  K  T ++++IAVGGRP+     G  +  I+SDDIF  ++
Sbjct: 121 ALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSLEK 179

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTL+VGA Y+ LECAGF+ G+GYD  +MVRSI+LRGFDQ MA  + + ME    + F
Sbjct: 180 APGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRGVHF 238

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           I    P  I K  +G+LLV W   D +  ++ FDTVL A GR P   +L  +  G+KL P
Sbjct: 239 IYEAKPSKIEKQADGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLKLVP 298

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           +T +I   +EQT+ PNVYA+GDV+   PELTPVAI AGRLLARRL+ N T  MDY  V T
Sbjct: 299 ETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVNVAT 358

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VF+P+EYGC GLSEEA+I   G D +EIYH  + P E+ +    +   S+CY+KVI  +
Sbjct: 359 TVFSPLEYGCVGLSEEAAIAIHGNDKIEIYHAYYKPTEFFI---PQKDVSNCYLKVIAFR 415

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + D+ V+G H++GPNAGEV Q    A+K   T+ ++ + VGIHPT AE FT + VTK
Sbjct: 416 NGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHPTVAEEFTRISVTK 472


>ref|NP_001171497.1| thioredoxin reductase 1 isoform 2 [Apis mellifera]
          Length = 494

 Score =  469 bits (1207), Expect = e-130
 Identities = 247/477 (51%), Positives = 327/477 (68%), Gaps = 12/477 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA  +G KV VLD+V PS  G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 11  YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 70

Query: 64  SSLIGETIHKDSKAFGWTVGEQTF---DWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           ++L+GE+IH DS ++GW + +      DW  +  +V +++KS+N+  +VELR KK++Y N
Sbjct: 71  AALLGESIH-DSVSYGWQLPDPKTIKNDWEALRTAVQNHVKSVNWVTRVELRTKKIEYFN 129

Query: 121 LLGSFIDAHTLELWHPKKG-TKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
            LG F D HT+ L   K G  K  T ++++IAVGGRP+     G  +  I+SDDIF  ++
Sbjct: 130 ALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSLEK 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTL+VGA Y+ LECAGF+ G+GYD  +MVRSI+LRGFDQ MA  + + ME    + F
Sbjct: 189 APGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRGVHF 247

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           I    P  I K  +G+LLV W   D +  ++ FDTVL A GR P   +L  +  G+KL P
Sbjct: 248 IYEAKPSKIEKQADGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLKLVP 307

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           +T +I   +EQT+ PNVYA+GDV+   PELTPVAI AGRLLARRL+ N T  MDY  V T
Sbjct: 308 ETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVNVAT 367

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VF+P+EYGC GLSEEA+I   G D +EIYH  + P E+ +    +   S+CY+KVI  +
Sbjct: 368 TVFSPLEYGCVGLSEEAAIAIHGNDKIEIYHAYYKPTEFFI---PQKDVSNCYLKVIAFR 424

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + D+ V+G H++GPNAGEV Q    A+K   T+ ++ + VGIHPT AE FT + VTK
Sbjct: 425 NGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHPTVAEEFTRISVTK 481


>ref|XP_002056889.1| GJ16646 [Drosophila virilis]
 gb|EDW62375.1| GJ16646 [Drosophila virilis]
          Length = 556

 Score =  469 bits (1206), Expect = e-130
 Identities = 248/477 (51%), Positives = 328/477 (68%), Gaps = 11/477 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGL+C+KEA  +G +V  LD+VKP+ +GT WG+GGTCVNVGCIPKKLM
Sbjct: 74  YDYDLVVIGGGSGGLSCAKEAVAHGARVACLDFVKPTPIGTKWGVGGTCVNVGCIPKKLM 133

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ+SL+GE +H ++ A+GW V ++   DW +++ SV ++IKS+N+  +V+LRDKKV+Y N
Sbjct: 134 HQASLLGEAVH-EAAAYGWNVDDKIKPDWNKLVSSVQNHIKSVNWVTRVDLRDKKVEYIN 192

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
            LGSF+D HTL     K G +T+T +  VIAVGGRP+     G  +  I+SDD+F     
Sbjct: 193 GLGSFVDPHTLSA-KLKSGDRTITAQTFVIAVGGRPRYPNIPGAVEYGITSDDLFSLDRE 251

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I F+
Sbjct: 252 PGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAASME-ERGIPFL 310

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           R  VP S+ K  +G+LLVK+  T  GE   + FDTVL A GR   V  L L  AGV  + 
Sbjct: 311 RKTVPLSVEKQSDGRLLVKYENTETGEIDSDVFDTVLWAIGRKGLVEDLNLHNAGVLTHK 370

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
              ++  E E T+ P++YA+GD+I   PELTPVA+ AGRLLARRLY +    MDY  V T
Sbjct: 371 DKIQVDCE-ETTNVPHIYAVGDIIYGKPELTPVAVLAGRLLARRLYADSDLRMDYADVAT 429

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EY C GLSEE +++ +G + +E++H  + P E+ +    + +   CYVK +  +
Sbjct: 430 TVFTPLEYACVGLSEEDAVKTYGAEEIEVFHGYYKPTEFFI---PQKSVRYCYVKAVAQR 486

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           S ++ V G HYLGP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 487 SGEQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHPTTAEEFTRLSITK 543


>gb|EFV61343.1| thioredoxin reductase 1, cytoplasmic [Trichinella spiralis]
          Length = 598

 Score =  468 bits (1203), Expect = e-129
 Identities = 240/481 (49%), Positives = 331/481 (68%), Gaps = 11/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YDLVVIGGGSGGLA +K+AA  GK+V VLD+V P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 110 HQYDLVVIGGGSGGLAAAKDAALAGKRVAVLDFVTPTPLGTTWGLGGTCVNVGCIPKKLM 169

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H +SL+G+ +  D++ FGW  GE+    W  M+ ++ S+I ++N+ Y+V+LR+K V Y N
Sbjct: 170 HCTSLLGKNL-ADARKFGWKYGEEVKHSWTDMVTAIQSHITALNWNYRVQLREKSVTYLN 228

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG-GDLAISSDDIFWRKEA 179
             G+F+ +H+++    +   + +T+   +IA G RP+ L   G  +  I+SDD+F     
Sbjct: 229 AFGTFVGSHSIKATDKRNKEQIITSDRFIIATGLRPRYLDVPGVKEYCITSDDLFSLPYC 288

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTL VGASYV+LECAGF++G+G DV +MVRSILLRGFDQDMA++IG  M+    + FI
Sbjct: 289 PGKTLCVGASYVSLECAGFLRGLGLDVTVMVRSILLRGFDQDMANRIGNHMQTVEGVRFI 348

Query: 240 RGCVPQSIMKLENGQLLVKWTTA---DGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
             C+P  I +L++GQ  +   TA   DGE   + ++TVL A GRD     L LDK GV+ 
Sbjct: 349 YKCIPTKIERLQDGQPGLFRVTAKKEDGEEVVDEYNTVLIAIGRDALTDALNLDKVGVET 408

Query: 297 NPKTGRI--WVENEQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYD 353
           NP+  +I  +   + T+ P +YAIGDV+D   ELTPVAI+AGRLLA+R++   + L D  
Sbjct: 409 NPENKKILCYANEQSTTAPYIYAIGDVLDRGLELTPVAIKAGRLLAKRMFGLSSILCDRY 468

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
              T VFTP+EYGCCG+SEE +IE++GE N+E++H  FTPLE+++    R  +  CY K+
Sbjct: 469 LTPTTVFTPLEYGCCGMSEEEAIEEYGEINIEVFHSYFTPLEYTVPK--RDDSEHCYAKL 526

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  D  ++GFH LGPNAGE+TQ   + +KL  T      +VGIHPT AE+FT L VT
Sbjct: 527 ICNKQDDMRILGFHLLGPNAGEITQGFAIGLKLKATKHDFDLLVGIHPTCAEVFTQLTVT 586

Query: 474 K 474
           K
Sbjct: 587 K 587


>ref|XP_001014761.2| thioredoxin and glutathione reductase family protein [Tetrahymena
           thermophila]
 gb|EAR94708.2| thioredoxin and glutathione reductase family protein [Tetrahymena
           thermophila SB210]
          Length = 489

 Score =  468 bits (1203), Expect = e-129
 Identities = 251/479 (52%), Positives = 328/479 (68%), Gaps = 10/479 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YD  VIGGGSGGLA +KEAA +G +V V D+VKPS VGT WGLGGTCVNVGCIPKKLM
Sbjct: 5   FKYDFFVIGGGSGGLAAAKEAASFGARVAVADFVKPSPVGTKWGLGGTCVNVGCIPKKLM 64

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT--FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           H ++  GE+ H+  K  GWT  ++    +W  M++ V ++IK +N+ YKVEL +K+VKY 
Sbjct: 65  HFAASYGES-HEAQKNMGWTEIKEKNKHEWQPMVERVQAHIKKLNWGYKVELAEKEVKYY 123

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGGD-LAISSDDIFWRKE 178
           N L S +  +T+EL + K   + VT + ++IAVGGRP  L     + L I+SDDIF  + 
Sbjct: 124 NSLASIVGKNTIELTNRKGEKEQVTAKYILIAVGGRPTFLDIPNTEKLVITSDDIFSMQN 183

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASY+ALECAGF+ G GYDV +MVRSILLRGFDQ++A+KIGE+M      +F
Sbjct: 184 PPGKTLVVGASYIALECAGFLAGFGYDVTVMVRSILLRGFDQEIAEKIGEYM-ARHGTKF 242

Query: 239 IRGCVPQSIMKLENGQLLVKWTT-ADGEA-CEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           IRG VP  I    +G+  V W +  +G+   EE FDTV+ A GR  D   +G++  G+K 
Sbjct: 243 IRGTVPHHIEATPDGRRRVVWKSPVEGQGDVEEIFDTVMLAIGRTSDTKNIGVETMGIKT 302

Query: 297 NPKTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
            P    I  +++ T+  N++AIGD +D  PELTP AI+AGRLLARRL+N +T LMDY+ +
Sbjct: 303 KPNGKIIANDDDTTNVENIFAIGDCVDKRPELTPTAIKAGRLLARRLFNGDTKLMDYNSI 362

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTPIEYG  GLSEE +  K+GEDN+++Y+  FTPL+WS S          + K+I 
Sbjct: 363 PTTVFTPIEYGTIGLSEEDAKTKYGEDNIKVYYSIFTPLDWSYSDHKHD--DKGHAKLIV 420

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +K+ D+ VVGFHYLGP+AGEVTQ   +A K   T     +VVGIHPT AE FTTL+  K
Sbjct: 421 NKADDERVVGFHYLGPHAGEVTQGFAIAFKFKATKANFDDVVGIHPTYAEEFTTLKNVK 479


>gb|EFR25272.1| hypothetical protein AND_09546 [Anopheles darlingi]
          Length = 510

 Score =  467 bits (1202), Expect = e-129
 Identities = 255/484 (52%), Positives = 328/484 (67%), Gaps = 16/484 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLAC+K+A + G KV VLD+VKPS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 19  YDYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPQGTRWGLGGTCVNVGCIPKKLM 78

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT---FDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE IH DS+ +GW   +      DWA + +SV ++IKS+N+  +V+LRD+KV+Y
Sbjct: 79  HQASLLGEAIH-DSQPYGWQFTDPASVRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEY 137

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N LG F DAHT+         + + T+ VVIAVGGRP+     G  +  I+SDDIF   
Sbjct: 138 INGLGYFRDAHTVVARMKNDTERELRTKHVVIAVGGRPRYPDIPGAVEHCITSDDIFSLP 197

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
            APGKTL+VGA Y+ LECAGF+KG+GYDV +MVRSILLRGFDQ MA  IG+ M VE  I 
Sbjct: 198 RAPGKTLLVGAGYIGLECAGFLKGLGYDVTVMVRSILLRGFDQQMATMIGDSM-VEKGIR 256

Query: 238 FIRGCVPQSIMKLENGQLLVKWTT--ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           F     P ++ K  +G+LLV++ T  A+    E+ FDTVL A GR  +   L LDKAGV 
Sbjct: 257 FHHKTRPLAVEKQPDGRLLVRYETEGAESGTAEDTFDTVLFAIGRQAETGSLQLDKAGVV 316

Query: 296 L--NPKTGRIWVENE--QTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLM 350
                K+ ++ V++E  +T+  NVYA+GDV+   PELTPVAI AGR++ARRL+   +  M
Sbjct: 317 TADGGKSDKLDVDDESHRTNVENVYAVGDVLYRKPELTPVAIHAGRIIARRLFGGSSETM 376

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DY  V T VFTP+EYGC GLSEEA+    G+DN+E+YH  + P E+ +    + +   CY
Sbjct: 377 DYRDVATTVFTPLEYGCVGLSEEAAEAAHGKDNIEVYHAYYKPTEFFV---PQRSVRYCY 433

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
           +K +  +  D+ V+G H+LGP AGEV Q    A+K G T   + N VGIHPT AE FT L
Sbjct: 434 LKTVALREGDQRVLGLHFLGPAAGEVIQGFAAALKCGLTMKVLRNTVGIHPTVAEEFTRL 493

Query: 471 EVTK 474
            +TK
Sbjct: 494 AITK 497


>ref|XP_797733.2| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus]
 ref|XP_001181272.1| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus]
          Length = 490

 Score =  467 bits (1202), Expect = e-129
 Identities = 238/482 (49%), Positives = 337/482 (69%), Gaps = 18/482 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL VIGGGSGGLAC+KEAA + KKV VLDYV PS  GT WGLGGTCVNVGCIPKKL
Sbjct: 8   SYDYDLAVIGGGSGGLACAKEAAGFDKKVIVLDYVDPSPQGTKWGLGGTCVNVGCIPKKL 67

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           +H +SL+ E++H D+K +GW V +     W+ ++  +  ++KS+N+ ++V+L+DK V+Y 
Sbjct: 68  LHHASLLRESMH-DAKHYGWQVPDDIGLSWSTLIGGIQGHVKSLNWGHRVQLQDKNVEYV 126

Query: 120 NLLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPK-----PLACEGGDLAISSDDI 173
           N  GSFID HT+++   K G +T  +  ++V+A GGRPK     P A E G   I+SDDI
Sbjct: 127 NGKGSFIDEHTVKV-KMKDGKETQFSAANIVLATGGRPKYPDKVPGAMEYG---ITSDDI 182

Query: 174 FWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVE 233
           F  K  PG++LV+G SYVALECAGF+ G+G+   +MVRSI LRGFDQ M+  + + ME  
Sbjct: 183 FSLKTPPGRSLVIGGSYVALECAGFLHGLGFPTTVMVRSICLRGFDQQMSRLVADHMEA- 241

Query: 234 SKIEFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           S I+F+   VP+S+ K +NG L V+W +  G+     FDTV+ A GR+P+ A+LGLD  G
Sbjct: 242 SGIQFLWQQVPESVAKNQNGSLNVRWRSDQGQEGHGEFDTVMFAVGREPETAQLGLDNTG 301

Query: 294 VKLNPKTGRIWVENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           V+L+ + G++   NEQ+S P+++AIGD++++  ELTPVAI+ G+LLA+RL+   T  M+Y
Sbjct: 302 VQLS-EGGKVMGSNEQSSVPHIHAIGDILESGIELTPVAIRTGKLLAQRLFGQGTEHMNY 360

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           ++V T VFTP+EY C GLSEE + E++GED++E+YH  + PLE+ + +     A  CY+K
Sbjct: 361 EQVATTVFTPLEYSCVGLSEETATERYGEDHIEVYHAFYKPLEYVVPN---KPAEQCYIK 417

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
            IC +  D+ ++G H  GP AGE+ Q   LA+K+G TY  + + +GIHPT AE    + +
Sbjct: 418 AICLRDGDQRILGLHITGPGAGEIMQGFALAVKMGATYQHLSSTIGIHPTCAEEVVKIHI 477

Query: 473 TK 474
           TK
Sbjct: 478 TK 479


>ref|XP_002697197.1| PREDICTED: thioredoxin reductase 3 [Bos taurus]
 gb|DAA16756.1| thioredoxin reductase 3 [Bos taurus]
          Length = 790

 Score =  467 bits (1201), Expect = e-129
 Identities = 243/481 (50%), Positives = 328/481 (68%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGL+C++EAA  G+KV VLD+V PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 304 YDYDLIVIGGGSGGLSCAQEAAVLGRKVMVLDFVVPSPRGTAWGLGGTCVNVGCIPKKLM 363

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q    WA M +++ S+I S+++ +++ LR+K V Y N
Sbjct: 364 HQAALLGQAL-TDSRKFGWEYSQQVRHSWATMTEAIQSHIGSLSWGHRLALREKAVTYVN 422

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ H ++  + K      T    VIA G RP+ L   G  +  I+SDD+F     
Sbjct: 423 SFGEFVEHHKVKATNEKGQEVLYTAAKFVIATGERPRYLGIPGDREYCITSDDLFSLPYC 482

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PG TLVVGASYVALECAGF+ G+G +V +MVRS+LLRGFDQ+MA+K+G  M+ +  + F+
Sbjct: 483 PGATLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGASMQ-QLGVRFL 541

Query: 240 RGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + +LE G      +V  +T   E  E  ++TVL A GRD    KLGL+K GV 
Sbjct: 542 RKFVPVEVQQLERGLPGRLKVVAKSTEGTETIEGIYNTVLLAIGRDSCTKKLGLEKIGVN 601

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYD 353
           ++ KTG+I V + EQTS   VYA+GDV++  P+LTPVA+QAG+LLARRL+   +   DY 
Sbjct: 602 VSEKTGKIPVNDEEQTSVSYVYAVGDVLEGKPQLTPVAVQAGKLLARRLFGGRSEKCDYV 661

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYGCCG SEE + E +  +NL +YH  F PLEW+++       ++CY K+
Sbjct: 662 NVPTVVFTPLEYGCCGYSEEKAGEVYQAENLNVYHTLFWPLEWTVAGRDN---NTCYAKI 718

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  +  V+GFH LGPNAGE+TQ    AMK G T   + + +GIHPT  E+FTTLE+T
Sbjct: 719 ICNKLDNDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEIT 778

Query: 474 K 474
           K
Sbjct: 779 K 779


>ref|NP_001179038.1| thioredoxin reductase 3 [Bos taurus]
          Length = 578

 Score =  467 bits (1201), Expect = e-129
 Identities = 243/481 (50%), Positives = 328/481 (68%), Gaps = 13/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGL+C++EAA  G+KV VLD+V PS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 92  YDYDLIVIGGGSGGLSCAQEAAVLGRKVMVLDFVVPSPRGTAWGLGGTCVNVGCIPKKLM 151

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q    WA M +++ S+I S+++ +++ LR+K V Y N
Sbjct: 152 HQAALLGQAL-TDSRKFGWEYSQQVRHSWATMTEAIQSHIGSLSWGHRLALREKAVTYVN 210

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
             G F++ H ++  + K      T    VIA G RP+ L   G  +  I+SDD+F     
Sbjct: 211 SFGEFVEHHKVKATNEKGQEVLYTAAKFVIATGERPRYLGIPGDREYCITSDDLFSLPYC 270

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PG TLVVGASYVALECAGF+ G+G +V +MVRS+LLRGFDQ+MA+K+G  M+ +  + F+
Sbjct: 271 PGATLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGASMQ-QLGVRFL 329

Query: 240 RGCVPQSIMKLENG----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           R  VP  + +LE G      +V  +T   E  E  ++TVL A GRD    KLGL+K GV 
Sbjct: 330 RKFVPVEVQQLERGLPGRLKVVAKSTEGTETIEGIYNTVLLAIGRDSCTKKLGLEKIGVN 389

Query: 296 LNPKTGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYD 353
           ++ KTG+I V + EQTS   VYA+GDV++  P+LTPVA+QAG+LLARRL+   +   DY 
Sbjct: 390 VSEKTGKIPVNDEEQTSVSYVYAVGDVLEGKPQLTPVAVQAGKLLARRLFGGRSEKCDYV 449

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EYGCCG SEE + E +  +NL +YH  F PLEW+++       ++CY K+
Sbjct: 450 NVPTVVFTPLEYGCCGYSEEKAGEVYQAENLNVYHTLFWPLEWTVAGRDN---NTCYAKI 506

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           IC+K  +  V+GFH LGPNAGE+TQ    AMK G T   + + +GIHPT  E+FTTLE+T
Sbjct: 507 ICNKLDNDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEIT 566

Query: 474 K 474
           K
Sbjct: 567 K 567


>ref|XP_002010389.1| GI15898 [Drosophila mojavensis]
 gb|EDW07706.1| GI15898 [Drosophila mojavensis]
          Length = 601

 Score =  467 bits (1201), Expect = e-129
 Identities = 246/477 (51%), Positives = 331/477 (69%), Gaps = 11/477 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGL+C+KEA  +G +V  LD+VKP+ +GT WG+GGTCVNVGCIPKKLM
Sbjct: 119 YDYDLVVIGGGSGGLSCAKEAVAHGARVACLDFVKPTPLGTKWGVGGTCVNVGCIPKKLM 178

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF-DWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+GE +H ++ A+GW V ++   DW++++ +V ++IKS+N+  +V+LRDKKV+Y N
Sbjct: 179 HQAALLGEAVH-EAAAYGWNVDDKIKPDWSKLVTAVQNHIKSVNWVTRVDLRDKKVEYIN 237

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
            LGSF+D+HT+     K G +T+T +  VIAVGGRP+     G  +  I+SDD+F     
Sbjct: 238 GLGSFVDSHTISA-KLKGGERTITAQTFVIAVGGRPRYPNIPGAVEYGITSDDLFSLDHE 296

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGA Y+ LECAGF+KG+GY+  +MVRSI+LRGFDQ MA+ +   ME E  I F+
Sbjct: 297 PGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAAAME-ERGIPFL 355

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           R  VP S+ K  +G+LLVK+  T  GE   + FDTVL A GR   V  L LD AGV  + 
Sbjct: 356 RKTVPLSVEKQSDGRLLVKYENTETGEVDSDVFDTVLWAIGRKGLVDDLNLDNAGVLTHK 415

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
              ++  E E T+ P++YA+GD+I   PELTPVA+ AGRLLARRLY +    MDY  V T
Sbjct: 416 DKIQVDCE-ETTNVPHIYAVGDIIYGKPELTPVAVLAGRLLARRLYADSELRMDYVDVAT 474

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EY C GLSEE +I+ +G + +E++H  + P E+ +    + +   CYVK +  +
Sbjct: 475 TVFTPLEYACVGLSEEDAIKLYGAEEIEVFHGYYKPTEFFI---PQKSVRYCYVKAVAQR 531

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + ++ V G HYLGP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 532 NGEQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHPTTAEEFTRLSITK 588


>gb|ADD18525.1| thioredoxin reductase-1 [Glossina morsitans morsitans]
          Length = 499

 Score =  466 bits (1200), Expect = e-129
 Identities = 239/479 (49%), Positives = 333/479 (69%), Gaps = 13/479 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLAC+KEA   G KV  LD+VKP+  G+ WGLGGTCVNVGC+PKKLM
Sbjct: 15  YGYDLIVIGGGSGGLACAKEAIVNGAKVACLDFVKPTPHGSKWGLGGTCVNVGCVPKKLM 74

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF---DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE +  D++A+GW + +      DW ++++SV ++IKS+N+  +V+LRDKK++Y
Sbjct: 75  HQASLLGEAL-SDAQAYGWEIPDAKNIKPDWGKLVQSVQNHIKSVNWVTRVDLRDKKIEY 133

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGGDLAISSDDIFWRKE 178
            N LGSF D+HT+ +       +TV+ R++VIAVGGRP+     G +L I+SDD+F   +
Sbjct: 134 LNGLGSFRDSHTILVKMKNNTERTVSARNIVIAVGGRPRYPNIPGAELGITSDDLFSLDK 193

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG+TL+VGA Y+ LECAGF++G+GYD  +MVRSI+LRGFDQ MA+ + + M VE  ++F
Sbjct: 194 PPGRTLIVGAGYIGLECAGFLRGLGYDATVMVRSIILRGFDQQMANMVADSM-VERGVKF 252

Query: 239 IRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           I   +P+S+ K  +   LVK+   +  E   + +DTV+ A GR   +  L L   G++L 
Sbjct: 253 IHKTIPKSVEKTGHNTYLVKYINIETKEEGSDEYDTVMWAIGRKGLLEDLNLTSIGIEL- 311

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
            K  +I V + EQT+  NVYA+GD+    PELTPVAI AGRLLARRL+ N T LMDY  V
Sbjct: 312 -KNDKILVNDAEQTNVSNVYAVGDITYGRPELTPVAIHAGRLLARRLFGNSTQLMDYCNV 370

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VF+P+EY C G+SEE + +++GEDN+E++H  + P E+ +    + +   CYVK + 
Sbjct: 371 ATTVFSPLEYACVGMSEEDAAQEYGEDNIEVFHGFYKPTEFFI---PQKSVRYCYVKAVA 427

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           ++S D+ V+G HYLGP AGE+ Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 428 ERSGDQRVLGLHYLGPVAGEIIQGFAAAVKCGLTMKILMNTVGIHPTTAEEFTRLNITK 486


>gb|AAN32903.1| thioredoxin reductase TR1 [Chlamydomonas reinhardtii]
          Length = 533

 Score =  465 bits (1196), Expect = e-129
 Identities = 259/511 (50%), Positives = 333/511 (65%), Gaps = 42/511 (8%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDLVVIGGGSGGLAC+KEAAK GKKVC+LDYV PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 14  YEYDLVVIGGGSGGLACAKEAAKLGKKVCLLDYVVPSPAGTSWGLGGTCVNVGCIPKKLM 73

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H + L+GE    D++ +GW + E+   +W  ++  V ++I S+N+ Y+V LR+  VKY N
Sbjct: 74  HNAGLLGEGF-SDARGYGWKLPEKIEMNWEDLVMGVQNHIGSLNWGYRVALREASVKYLN 132

Query: 121 LLGSFIDAHTLELWHPKKGTK-TVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             GSF+DAHT+E    + GTK T+T   VVIAVGGRPK L   G  +L I+SDDIF R  
Sbjct: 133 AKGSFVDAHTVEAVE-RNGTKHTLTAERVVIAVGGRPKYLGVPGDKELCITSDDIFSRAT 191

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASY+ALECAGF++ +GY+V +M RSI LRGFDQ++A+ IG+ ME    +  
Sbjct: 192 PPGKTLVVGASYIALECAGFLRALGYEVAVMARSIFLRGFDQEIAELIGKDME-RRGVRM 250

Query: 239 IRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           I+  VP +  + +  Q+   +   D G    E+FDTVL A GRD     LGL+K GV  +
Sbjct: 251 IKPAVPTAFER-DGEQIKCTFKNLDFGVEMSESFDTVLLAVGRDACTFDLGLEKVGVTYD 309

Query: 298 PKTGRIWVENEQTSTPNVYAIGDVID-----------------------------APELT 328
             +G+I V  EQT+ P++YAIGDV++                             A ELT
Sbjct: 310 KSSGKIPVTAEQTNVPSIYAIGDVLESRQVPGQGGRKLMGLTCSLAQTLSPPDPLAQELT 369

Query: 329 PVAIQAGRLLARRLYNNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYH 388
           PVAI+AG  LARRLY   T  MDYD V T VFTP+EYGC G SEEA+  K+G DN+E+Y 
Sbjct: 370 PVAIKAGIRLARRLYAGATLQMDYDAVPTTVFTPLEYGCVGYSEEAATVKYGADNIEVYV 429

Query: 389 QNFTPLEWSLSSATR-----PAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLA 443
               PLEW+++          A +S +VK+I + + ++ VVG HYLGPNAGE+ Q + +A
Sbjct: 430 SYLKPLEWTMNHEEHNGEPVRADNSVFVKLITNTADNERVVGAHYLGPNAGEIIQGVAVA 489

Query: 444 MKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           +K   T     + +GIHPT AE FT LEVTK
Sbjct: 490 VKANATKADFDDCIGIHPTVAEEFTILEVTK 520


>ref|XP_001958552.1| GF23459 [Drosophila ananassae]
 gb|EDV41358.1| GF23459 [Drosophila ananassae]
          Length = 514

 Score =  463 bits (1191), Expect = e-128
 Identities = 243/484 (50%), Positives = 334/484 (69%), Gaps = 22/484 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGS GLAC+KEA   G +V   DYVKP+ VGT WGLGGTCVNVGCIPKKLM
Sbjct: 29  FDYDLVVLGGGSAGLACAKEAVDCGARVLCFDYVKPTPVGTKWGLGGTCVNVGCIPKKLM 88

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V ++    DW ++++SV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 89  HQASLLGEAVH-EAVAYGWNVNDKNIRPDWCKLVRSVQNHIKSVNWVTRVDLRDKKVEYV 147

Query: 120 NLLGSFIDAHTLELWHPKKG--TKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWR 176
           N +G+F+D HT+E + PK G     VT ++VV+AVGGRP+  +  G  +  I+SDDIF  
Sbjct: 148 NSMGAFVDGHTIE-YVPKSGQAKSRVTAKNVVVAVGGRPRYPSIPGATEFGITSDDIFSY 206

Query: 177 KEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKI 236
              PG+TLVVGA YV LECA F+KG+GYD  +MVRSI+LRGFD+ M++ +   M  E  I
Sbjct: 207 DREPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSELLAAMMS-ERGI 265

Query: 237 EFIRGCVPQSIMKLENGQLLVKW----TTADGEACEEAFDTVLNATGRDPDVAKLGLDKA 292
            F+   +P S+ +  +G+LLV++    T  DG    + FDTVL A GR   +  L L+ A
Sbjct: 266 SFLETTIPSSVERQSDGRLLVRFRNTTTQTDG---SDVFDTVLWAIGRRGLIEDLNLEAA 322

Query: 293 GVKLNPKTGRIWVE-NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLM 350
           GVK   +  +I V+ +E T+ P+++A+GD++   PELTPVAI AGRLLARRL+   T LM
Sbjct: 323 GVK--TQNDKIVVDRSEATNVPHIFAVGDIVYGRPELTPVAILAGRLLARRLFAGSTQLM 380

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DY  V T VFTP+EY C G+SEE +IEK G DN+E++H  + P E+ +    + +   CY
Sbjct: 381 DYADVATTVFTPLEYACVGMSEETAIEKHGADNIEVFHGYYKPTEFFI---PQKSVRFCY 437

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
           +K + + + D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L
Sbjct: 438 LKAVAEIAGDQKILGLHYMGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRL 497

Query: 471 EVTK 474
            +TK
Sbjct: 498 SITK 501


>ref|XP_002047939.1| GJ11643 [Drosophila virilis]
 gb|EDW70281.1| GJ11643 [Drosophila virilis]
          Length = 517

 Score =  462 bits (1188), Expect = e-128
 Identities = 242/482 (50%), Positives = 328/482 (68%), Gaps = 19/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGSGGLAC+KEA +YG  V   D+VKP+  GT WG+GGTCVNVGCIPKKLM
Sbjct: 33  YDYDLVVLGGGSGGLACAKEAVEYGAHVLCFDFVKPTPAGTKWGVGGTCVNVGCIPKKLM 92

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V +Q    DW +++KSV  +IKS+N+  +V+LRDKKV+Y 
Sbjct: 93  HQASLLGEAVH-EAVAYGWNVNDQNIKPDWKKLVKSVQDHIKSVNWVTRVDLRDKKVEYV 151

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N +G F+D HT+E    +   K +T + VV+AVGGRP+  +  G  +  I+SDDIF  ++
Sbjct: 152 NSIGRFVDPHTIEYIQKQGERKQLTAKYVVVAVGGRPRYPSIPGATEFGITSDDIFSYEK 211

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG+TLVVGA YV LECA F+KG+GYD  +MVRSI+LRGFD+ M++ +   M +E  I F
Sbjct: 212 EPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSEFLAAMM-LERGIRF 270

Query: 239 IRGCVPQSIMKLENGQLLVKW----TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           +   +P ++ +  +G+LLVK+    T  DG    + FDTVL A GR      L L  AGV
Sbjct: 271 LNTTIPLAVERRADGKLLVKYQNTTTKTDG---SDVFDTVLWAIGRKGLTEDLNLGAAGV 327

Query: 295 K-LNPKTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           +  N K   I    E T+ P+++A+GD+I   PELTPVAI +GRLLARRL+   T LMDY
Sbjct: 328 QTYNDKI--IVDHTEATNVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDY 385

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EY C G+SEE +IEK G +N+E++H  + P E+ +    + +   CY+K
Sbjct: 386 TDVATTVFTPLEYSCVGMSEEMAIEKMGAENIEVFHAYYKPTEFFI---PQKSVRHCYLK 442

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
            + + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +
Sbjct: 443 AVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSI 502

Query: 473 TK 474
           TK
Sbjct: 503 TK 504


>dbj|BAH11490.1| unnamed protein product [Homo sapiens]
          Length = 459

 Score =  461 bits (1186), Expect = e-127
 Identities = 244/452 (53%), Positives = 315/452 (69%), Gaps = 13/452 (2%)

Query: 31  VLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQSSLIGETIHKDSKAFGWTVGEQT-FDW 89
           VLD+V P+ +GT WGLGGTCVNVGCIPKKLMHQ++L+G+ + +DS+ +GW V E    DW
Sbjct: 2   VLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQAL-QDSRNYGWKVEETVKHDW 60

Query: 90  AQMLKSVNSYIKSINFKYKVELRDKKVKYENLLGSFIDAHTLELWHPKKGTKTVTTRDVV 149
            +M+++V ++I S+N+ Y+V LR+KKV YEN  G FI  H ++  + K   K  +    +
Sbjct: 61  DRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKDKEKIYSAERFL 120

Query: 150 IAVGGRPKPLACEGG-DLAISSDDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKI 208
           IA G RP+ L   G  +  ISSDD+F     PGKTLVVGASYVALECAGF+ G+G DV +
Sbjct: 121 IATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTV 180

Query: 209 MVRSILLRGFDQDMADKIGEFMEVESKIEFIRGCVPQSIMKLENGQ----LLVKWTTADG 264
           MVRSILLRGFDQDMA+KIGE ME E  I+FIR  VP  + ++E G      +V  +T   
Sbjct: 181 MVRSILLRGFDQDMANKIGEHME-EHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSE 239

Query: 265 EACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPKTGRIWV-ENEQTSTPNVYAIGDVI- 322
           E  E  ++TV+ A GRD    K+GL+  GVK+N KTG+I V + EQT+ P +YAIGD++ 
Sbjct: 240 EIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILE 299

Query: 323 DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGED 382
           D  ELTPVAIQAGRLLA+RLY   T   DY+ V T VFTP+EYG CGLSEE ++EKFGE+
Sbjct: 300 DKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEE 359

Query: 383 NLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGL 442
           N+E+YH  F PLEW++ S      + CY K+IC+   ++ VVGFH LGPNAGEVTQ    
Sbjct: 360 NIEVYHSYFWPLEWTIPSRDN---NKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAA 416

Query: 443 AMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           A+K G T  Q+ + +GIHP  AE+FTTL VTK
Sbjct: 417 ALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTK 448


>gb|EGB07743.1| selenoprotein [Aureococcus anophagefferens]
          Length = 498

 Score =  461 bits (1185), Expect = e-127
 Identities = 249/480 (51%), Positives = 311/480 (64%), Gaps = 13/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYD+VV+GGGSGGLACSKE AK G KV VLD+VKPS  G++WGLGGTCVNVGCIPKKLM
Sbjct: 12  FDYDVVVVGGGSGGLACSKECAKLGAKVAVLDFVKPSPAGSTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGETIHKDSKAFGWT-VGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H +S+IGET+  D+ AFGW        DW  M  +V  +IKS+NFKY+V LR+  + Y N
Sbjct: 72  HTASIIGETLKDDAAAFGWKDAAAGAHDWESMKSTVQDHIKSLNFKYRVALREAGITYLN 131

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGGDLAISSDDIFWRKEA 179
            LG F D +T+ L   KKG KT VT    ++AVGGRP  L C GG+ AI SDD+F   +A
Sbjct: 132 RLGEFEDKNTISLTD-KKGNKTSVTAARFIVAVGGRPNKLGCPGGEHAIDSDDLFSLPKA 190

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PG+ L VG  Y+ALEC GF  GMGY    MVRSILLRGFD++   KI    E   K   +
Sbjct: 191 PGRVLCVGGGYIALECGGFTAGMGYPTTCMVRSILLRGFDRECVGKI----EAHIKHHGV 246

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDK---AGVKL 296
           +  V  +  K+E        T  D       +DTVL ATGR  D A LG+D    A   +
Sbjct: 247 QLQVGVTPAKIEKDAATGVLTVTDSGGGVHEYDTVLVATGRYADTAALGIDNVPGASANV 306

Query: 297 NPKTGRIWVENEQ-TSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           N KT ++   +EQ    P+VYAIGDV++  PELTPVAI+AG  LARRL+  +T  MDY+ 
Sbjct: 307 NAKTKKLECVDEQLPGAPHVYAIGDVVEGRPELTPVAIEAGLRLARRLFGGKTEPMDYEC 366

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T +FTP+EYG  GLSE+ +  + GE N+E Y   F PLE++LS         C+ K++
Sbjct: 367 VATTIFTPLEYGTIGLSEDDAKAQLGECNVESYISEFAPLEYALSETRSERGDGCFAKLV 426

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            DKS  K VVGFHYLGPNAGE+TQ   +AM+ G TY   ++ VGIHPT AE FT++ VTK
Sbjct: 427 VDKSTGK-VVGFHYLGPNAGEITQGFSIAMRKGATYADFISTVGIHPTVAEEFTSMTVTK 485


>emb|CBN76987.1| Thioredoxin reductase [Ectocarpus siliculosus]
          Length = 773

 Score =  461 bits (1185), Expect = e-127
 Identities = 248/499 (49%), Positives = 316/499 (63%), Gaps = 66/499 (13%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLAC+KEAA+ GKKV  LD+VKPS++G+ WGLGGTCVNVGCIPKKLM
Sbjct: 304 YDYDLVVIGGGSGGLACAKEAARLGKKVACLDFVKPSVMGSKWGLGGTCVNVGCIPKKLM 363

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ----------------------TFDWAQMLKSVNSY 99
           HQ++L+     KD+  FGW  G +                      T DW  M++ V +Y
Sbjct: 364 HQAALLAGHA-KDAPFFGWPAGPEGEDGSRLEEAGGVAGGEGKRSVTHDWEVMVQGVQNY 422

Query: 100 IKSINFKYKVELRDKKVKYENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPL 159
           IK +NFKY+ +LR K V+Y N LG   DAHT+         + ++   VV+AVGGRP  L
Sbjct: 423 IKGLNFKYRTDLRSKGVEYINALGRLQDAHTVVATDKNNKERVLSCGSVVVAVGGRPNQL 482

Query: 160 ACEGGDLAISSDDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFD 219
            CEGG+LA++SDDIF  +  PGKTLVVGASYVALECAGF+ G+G D  +MVRSILLRGFD
Sbjct: 483 PCEGGELAMTSDDIFALRTPPGKTLVVGASYVALECAGFLTGLGVDTTVMVRSILLRGFD 542

Query: 220 QDMADKIGEFMEVESKIEFIRGCVPQSIMKLENGQLLVKWTTADGE---ACEEAFDTVLN 276
           Q +A++IG FME E    F+R  VPQ I K E G+LLV+W   +G+     EE FDTVL 
Sbjct: 543 QGIAERIGSFMEAEG-TRFLRPAVPQRISKTEQGRLLVRWREGEGDDQTTKEEEFDTVLA 601

Query: 277 ATGRDPDVAKLGLDKAGVKLNPKTGRIWVENEQTSTPNVYAIGDVID-APELTPVAIQAG 335
           ATGR  D   LGL++ GV L+   G++   NE+T+   V+ IGD ++  PELTP A+QAG
Sbjct: 602 ATGRRADTQGLGLERLGVTLS-NNGKMVCRNEETTVAGVFGIGDAVEGVPELTPSAVQAG 660

Query: 336 RLLARRLYNNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLE 395
           RLLA RL+  E                                   +N+E++H  FTPLE
Sbjct: 661 RLLAMRLFGGE-----------------------------------ENVEVFHSAFTPLE 685

Query: 396 WSLSSATRPAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVN 455
           W ++S  RP  ++CYVK +CD +  + VVG H+LGPNAGEV Q  G+ ++LG T D +  
Sbjct: 686 WQMNS-ERP-QNACYVKAVCDLTDSQRVVGLHFLGPNAGEVMQGFGVGIRLGMTMDDLRQ 743

Query: 456 VVGIHPTTAEIFTTLEVTK 474
           +VGIHPT AE  T L+ TK
Sbjct: 744 LVGIHPTVAEELTLLQTTK 762


>ref|XP_002009206.1| GI11388 [Drosophila mojavensis]
 gb|EDW19682.1| GI11388 [Drosophila mojavensis]
          Length = 515

 Score =  460 bits (1184), Expect = e-127
 Identities = 242/482 (50%), Positives = 330/482 (68%), Gaps = 19/482 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLAC+KEA +YG +V  LDYVKP+  GT WG+GGTCVNVGCIPKKLM
Sbjct: 31  FDYDLVVLGGGSGGLACAKEAVEYGARVLCLDYVKPTPAGTKWGVGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V ++    DW +++K V ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 91  HQASLLGEAVH-EAVAYGWNVNDRDIKPDWKKLVKVVQNHIKSVNWVTRVDLRDKKVEYV 149

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N +GSF++ HT++    +   K +T + VVIAVGGRP+    +G  +L I+SDDIF  ++
Sbjct: 150 NSIGSFVNPHTIKYKTKQGELKQLTAQYVVIAVGGRPRYPPIKGAIELGITSDDIFSYEK 209

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG+TLVVGA YV LECA F+KG+GYD  +MVRSI+LRGFD+ M++ +   M  E  I F
Sbjct: 210 EPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSEFLAAMM-TERGIHF 268

Query: 239 IRGCVPQSIMKLENGQLLVKW----TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           +   +P  + +   G+LLV++    T  DG    + FDTVL A GR   +  L L  AGV
Sbjct: 269 LNTTIPMGVERTPEGKLLVQYRNTTTQTDG---SDVFDTVLWAIGRKGLIEDLNLGAAGV 325

Query: 295 K-LNPKTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDY 352
           +  N K   I    E TS P+++A+GD+I   PELTPVAI +GRLLARRL+   T LMDY
Sbjct: 326 QTYNDKV--IVDHTEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDY 383

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
             V T VFTP+EY C G+SEE +IE+ G DN+E++H  + P E+ +    + +   CY+K
Sbjct: 384 TDVATTVFTPLEYSCVGMSEEMAIERLGADNIEVFHGYYKPTEFFI---PQKSFRHCYLK 440

Query: 413 VICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEV 472
            + + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +
Sbjct: 441 AVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSI 500

Query: 473 TK 474
           TK
Sbjct: 501 TK 502


>ref|XP_001942650.1| PREDICTED: similar to thioredoxin reductase [Acyrthosiphon pisum]
          Length = 493

 Score =  460 bits (1183), Expect = e-127
 Identities = 231/476 (48%), Positives = 328/476 (68%), Gaps = 8/476 (1%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL+VIGGGSGGLAC+KEA+ +GK+V VLD+V PS  GT+WG+GGTCVNVGCIPKKLM
Sbjct: 10  YDFDLLVIGGGSGGLACAKEASSFGKQVVVLDFVIPSEKGTTWGIGGTCVNVGCIPKKLM 69

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ+SL+GE+I ++++++GW + +  +F+W  ++++V ++IKS+N+  +V+LRDKK++Y N
Sbjct: 70  HQASLLGESI-QEARSYGWNIPDPISFNWESLVEAVQNHIKSVNWVTRVQLRDKKIEYVN 128

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG-GDLAISSDDIFWRKEA 179
             G F DAHT+         + +T +D+VIAVGGRP+     G  +  I+SDD+F    +
Sbjct: 129 GHGVFEDAHTVIAKMKNGKERRITAKDIVIAVGGRPRYPDFPGCKEYCITSDDLFSMPTS 188

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PG TLV+GA Y+ LECAGF+KG+GY+  +MVRS+LLRGFD+ M D +   ME    + F+
Sbjct: 189 PGNTLVIGAGYIGLECAGFLKGLGYEATVMVRSMLLRGFDRGMVDLVQAEME-HKGVNFL 247

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
            G +P  + K  NG+LLV+W   D  +    FDTVL ATGR     +L    AG++++P+
Sbjct: 248 FGKIPVKVSKQPNGKLLVEWKGGDEVSSAWEFDTVLVATGRKALSEELNPSAAGLQVHPE 307

Query: 300 TGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCTA 358
           + +     EQT+ PN+YA+GDV+ + PELTPVAIQAG+LLA RLYN     MDYD V T 
Sbjct: 308 SFKFITNAEQTNIPNIYAVGDVLHERPELTPVAIQAGKLLAGRLYNGIQEQMDYDNVATT 367

Query: 359 VFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKS 418
           VF+P+EYGC GL+EE +I ++ E+ +E+YH  + P E+ +          CY+KVI    
Sbjct: 368 VFSPLEYGCVGLTEEEAINRYTENGIEVYHAYYKPTEFFIPQKN---VKHCYLKVITLLE 424

Query: 419 RDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             + V+G H++GP AGEV Q    A+K G TY  + + VGIHPT +E FT + +TK
Sbjct: 425 APQKVLGMHFIGPQAGEVIQGYAAAIKAGLTYQHLKDTVGIHPTVSEEFTRVAITK 480


>ref|XP_001984837.1| GH16699 [Drosophila grimshawi]
 gb|EDV97185.1| GH16699 [Drosophila grimshawi]
          Length = 514

 Score =  459 bits (1182), Expect = e-127
 Identities = 238/479 (49%), Positives = 329/479 (68%), Gaps = 13/479 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLAC+KEA +YG +V   DYVKP+  GT WG+GGTCVNVGCIPKKLM
Sbjct: 30  HDYDLVVLGGGSGGLACAKEAVEYGARVLCFDYVKPTPAGTKWGVGGTCVNVGCIPKKLM 89

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V ++    +W ++++SV ++IKS+N+  +V+LRDK+V+Y 
Sbjct: 90  HQASLLGEAVH-EAVAYGWNVNDRDIKPNWKKLIQSVQNHIKSVNWVTRVDLRDKQVEYV 148

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRKE 178
           N +G+F+DAHT+E    +   K ++  +VVIAVGGRP+ PL     +  I+SDDIF  + 
Sbjct: 149 NSMGAFVDAHTIEYRTKQGERKQLSAENVVIAVGGRPRYPLIPGAIEFGITSDDIFSYET 208

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PG+TLVVGA YV LECA F+KG+GY+  +MVRSI+LRGFD+ M++ +   M  +  I F
Sbjct: 209 EPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TDRGIPF 267

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEE-AFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +  C+P ++ +  NG LLVK+     +  E   FDTVL A GR      L L  AGVK  
Sbjct: 268 LNTCIPTAVQRQANGSLLVKYLNTTTQKEESGVFDTVLWAIGRKGLTEDLNLVAAGVK-- 325

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
               +I V++ E T+ P++YA+GD+I   PELTPVAI +GRLLARRL+     LMDY  V
Sbjct: 326 TVNDKIAVDHTEATNVPHIYAVGDIIYGRPELTPVAILSGRLLARRLFAGSKQLMDYTDV 385

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EY C G+SEE +IEK G +N+E++H  + P E+ +    + +   CY+K + 
Sbjct: 386 ATTVFTPLEYSCVGMSEEMAIEKLGAENIEVFHGYYKPTEFFI---PQKSVRYCYLKAVA 442

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 443 EVSGDQKILGLHYMGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSITK 501


>ref|XP_001973742.1| GG16263 [Drosophila erecta]
 gb|EDV52768.1| GG16263 [Drosophila erecta]
          Length = 518

 Score =  459 bits (1182), Expect = e-127
 Identities = 245/485 (50%), Positives = 335/485 (69%), Gaps = 22/485 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+ VGT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V ++    DW ++++SV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 91  HQASLLGEAVH-EAVAYGWNVDDKNLRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYV 149

Query: 120 NLLGSFIDAHTLEL---WHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFW 175
           N +GSF D+HT+E      P   ++ VT+  VV+AVGGRP+     G  +L I+SDDIF 
Sbjct: 150 NSMGSFRDSHTIEYVASTSPGAESRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFS 209

Query: 176 RKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESK 235
            +  PG+TLVVGA YV LECA F+KG+GY+  +MVRSI+LRGFD+ M+D +   M  E  
Sbjct: 210 YEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSDLLAAMM-TERG 268

Query: 236 IEFIRGCVPQSIMKLENGQLLVKW----TTADGEACEEAFDTVLNATGRDPDVAKLGLDK 291
           I F+   +P+++ +  +G+LLV++    T ADG    + FDTVL A GR   + +L L+ 
Sbjct: 269 IPFLGTTIPKAVERQADGRLLVRYRNTTTQADG---SDVFDTVLWAIGRKGLIEELNLEA 325

Query: 292 AGVKLNPKTGRIWVE-NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTL 349
           AGV+   +  +I V+  E TS P+++A+GD+I   PELTPVAI AGRLLARRL+   T L
Sbjct: 326 AGVR--TQDDKIVVDAAEATSVPHIFAVGDIIFGRPELTPVAILAGRLLARRLFAGATQL 383

Query: 350 MDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSC 409
           MDYD V T VFTP+EY C G+SEE +I   G DN+E++H  + P E+ +    + +   C
Sbjct: 384 MDYDDVATTVFTPLEYSCVGMSEETAIALRGADNIEVFHGYYKPTEFFI---PQKSVRHC 440

Query: 410 YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTT 469
           Y+K + + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT 
Sbjct: 441 YLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTR 500

Query: 470 LEVTK 474
           L +TK
Sbjct: 501 LSITK 505


>gb|EEZ99907.1| hypothetical protein TcasGA2_TC002698 [Tribolium castaneum]
          Length = 450

 Score =  459 bits (1181), Expect = e-127
 Identities = 238/448 (53%), Positives = 318/448 (70%), Gaps = 11/448 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           +YDLVVIGGGSGGLA +KEAA  G KV VLDYV PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   EYDLVVIGGGSGGLAAAKEAAGLGAKVAVLDYVTPSPKGTKWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGETIHKDSKAFGWTVGEQ---TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           Q++L+GE I +D+K++GW   +      DWA + ++V ++IKS+N+  +VELRDKKV+Y 
Sbjct: 69  QAALLGEAI-EDAKSYGWQFPQPENIKHDWASLRQAVQNHIKSVNWVTRVELRDKKVEYI 127

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N LG F D HT+     K+G +T+T++  +IAVGGRP+     G  +  I+SDDIF  +E
Sbjct: 128 NGLGVFKDPHTVHT-VTKQGERTLTSKYFLIAVGGRPRYPNIPGAVEYGITSDDIFSLEE 186

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           APGKTLVVGA Y+ LECAGF++G+GYD  +MVRS++LRGFDQ MA  I   ME E  ++F
Sbjct: 187 APGKTLVVGAGYIGLECAGFLRGLGYDATVMVRSVVLRGFDQQMAKLIASAME-EKGVKF 245

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           +  C+P+S+ K  + +LLVKW+   G+  E+ FDTVL A GR     +L LDKAGVK+  
Sbjct: 246 LHKCLPKSVEKRSDNKLLVKWSNETGQEFEDVFDTVLFAIGRRALTRELHLDKAGVKVAG 305

Query: 299 KTGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
              +I   NEQ++ P+++A+GDV+   PELTPVAI AGRLLARRL+ N T  MDYD V T
Sbjct: 306 DGEKIDAMNEQSNVPHIFAVGDVLYKKPELTPVAIHAGRLLARRLFGNSTVQMDYDNVAT 365

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VF+P+EYG  G+SEE +I++FGE+N+EIYH  + P E+ +    + + + CY+KV+  +
Sbjct: 366 TVFSPLEYGSVGISEETAIQRFGENNIEIYHAYYKPTEFFI---PQRSIAHCYLKVVAKR 422

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMK 445
              + V+G H++GP AGEV Q    AMK
Sbjct: 423 EGPQQVLGMHFIGPQAGEVIQGFAAAMK 450


>dbj|BAH12374.1| unnamed protein product [Homo sapiens]
          Length = 459

 Score =  459 bits (1181), Expect = e-127
 Identities = 243/452 (53%), Positives = 314/452 (69%), Gaps = 13/452 (2%)

Query: 31  VLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQSSLIGETIHKDSKAFGWTVGEQT-FDW 89
           VLD+V P+ +GT WGLGGTCVNVGCIPKKLMHQ++L+G+ + +DS+ +GW V E    DW
Sbjct: 2   VLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQAL-QDSRNYGWKVEETVKHDW 60

Query: 90  AQMLKSVNSYIKSINFKYKVELRDKKVKYENLLGSFIDAHTLELWHPKKGTKTVTTRDVV 149
            +M+++V ++I S+N+ Y+V LR+KKV YEN  G FI  H ++  + K   K  +    +
Sbjct: 61  DRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFL 120

Query: 150 IAVGGRPKPLACEGG-DLAISSDDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKI 208
           IA G RP+ L   G  +  ISSDD+F     PGKTLVVGASYVALECAGF+ G+G DV +
Sbjct: 121 IATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTV 180

Query: 209 MVRSILLRGFDQDMADKIGEFMEVESKIEFIRGCVPQSIMKLENGQ----LLVKWTTADG 264
           MVRSILLRGFDQDMA+KIGE ME E  I+FIR  VP  + ++E G      +V  +T   
Sbjct: 181 MVRSILLRGFDQDMANKIGEHME-EHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSE 239

Query: 265 EACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPKTGRIWV-ENEQTSTPNVYAIGDVI- 322
           E  E  ++T + A GRD    K+GL+  GVK+N KTG+I V + EQT+ P +YAIGD++ 
Sbjct: 240 EIIEGEYNTAMLAMGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILE 299

Query: 323 DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGED 382
           D  ELTPVAIQAGRLLA+RLY   T   DY+ V T VFTP+EYG CGLSEE ++EKFGE+
Sbjct: 300 DKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEE 359

Query: 383 NLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGL 442
           N+E+YH  F PLEW++ S      + CY K+IC+   ++ VVGFH LGPNAGEVTQ    
Sbjct: 360 NIEVYHSYFWPLEWTIPSRDN---NKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAA 416

Query: 443 AMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           A+K G T  Q+ + +GIHP  AE+FTTL VTK
Sbjct: 417 ALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTK 448


>ref|XP_514983.2| PREDICTED: thioredoxin reductase 2 isoform 4 [Pan troglodytes]
          Length = 450

 Score =  459 bits (1180), Expect = e-127
 Identities = 237/450 (52%), Positives = 320/450 (71%), Gaps = 13/450 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 7   DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 66

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 67  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 125

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 126 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 184

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 185 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 243

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W     G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 244 LRGCAPSRVRRLPDGQLQVTWEDCTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 303

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YA+GDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 304 PDTQKILVDSREATSVPHIYAVGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 363

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++   G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 364 PTTVFTPLEYGCVGLSEEEAVAHHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 420

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMK 445
            +   + V+G H+LGPNAGEVTQ   L +K
Sbjct: 421 LREPPQLVLGLHFLGPNAGEVTQGFALGIK 450


>ref|XP_001166615.1| PREDICTED: similar to mitochondrial thioredoxin reductase isoform 3
           [Pan troglodytes]
          Length = 481

 Score =  459 bits (1180), Expect = e-127
 Identities = 237/450 (52%), Positives = 320/450 (71%), Gaps = 13/450 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMH
Sbjct: 38  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 97

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 98  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 156

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 157 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 215

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 216 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-ASHGTRF 274

Query: 239 IRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W     G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 275 LRGCAPSRVRRLPDGQLQVTWEDCTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 334

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YA+GDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 335 PDTQKILVDSREATSVPHIYAVGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 394

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++   G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 395 PTTVFTPLEYGCVGLSEEEAVAHHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 451

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMK 445
            +   + V+G H+LGPNAGEVTQ   L +K
Sbjct: 452 LREPPQLVLGLHFLGPNAGEVTQGFALGIK 481


>ref|XP_003074475.1| thioredoxin reductase TR1 (ISS) [Ostreococcus tauri]
 emb|CAL50326.1| thioredoxin reductase TR1 (ISS) [Ostreococcus tauri]
          Length = 540

 Score =  458 bits (1179), Expect = e-127
 Identities = 246/484 (50%), Positives = 327/484 (67%), Gaps = 14/484 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YD+VVIGGGSGGLA +KEAAK+G K   LD+VKPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 12  YEYDVVVIGGGSGGLAAAKEAAKHGAKTACLDFVKPSPAGTTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           HQ+ L+GE+   D++ +GW +  +  DW +M++ + ++I S+NF Y+  LR+K V Y N 
Sbjct: 72  HQAGLLGESF-SDAREYGWKLASEGHDWPKMVEQIQNHIGSLNFGYRTTLREKNVTYINA 130

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGGDLAISSDDIFWRKEA 179
            G F DAHT+ +   K GT+ + T D VVIAVGGRP  P A    +  I+SDDIF + +A
Sbjct: 131 YGKFKDAHTI-VATKKNGTEQIITTDKVVIAVGGRPAYPDAPGAKECCITSDDIFSKPDA 189

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTL VGASY++LE AGF+  +G+D  + +RSI LRGFDQ++A+KI ++M  +    F+
Sbjct: 190 PGKTLCVGASYISLETAGFLTALGFDTSVAIRSIPLRGFDQEVAEKICKYMG-KHGTRFL 248

Query: 240 RGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           R   P    K E+G++ V +  T  G   EE FDTV+ A GRD     L L  AGV+ N 
Sbjct: 249 RDSQPSQFEKQEDGKIKVTFENTMFGNTFEETFDTVVCAVGRDAVTEGLDLPAAGVEFNA 308

Query: 299 KTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNE--TTLMDYDKV 355
           K G+I   +EQT+ PN+YAIGDV+D   ELTPVAI+AG  L RR++ +      M+YD V
Sbjct: 309 KNGKIPCVDEQTNVPNIYAIGDVLDTRQELTPVAIKAGVRLMRRVFADTPYKEKMNYDLV 368

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAA-----SSCY 410
            T VFTP+EYG  G+SEE ++E +G DN+E Y   F PLEW+++            ++C+
Sbjct: 369 PTTVFTPLEYGTIGMSEELAVETYGADNVECYISYFKPLEWTVNHEEHNGVPVRDDNACF 428

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
           VK+I + + D+ VVGFHYLGPNAGEVTQ   +AMK+G T       VGIHPT +E FT L
Sbjct: 429 VKLITNLADDERVVGFHYLGPNAGEVTQGYAVAMKMGATKRDFDETVGIHPTVSEEFTIL 488

Query: 471 EVTK 474
           E+TK
Sbjct: 489 EITK 492


>gb|AAN63052.1| thioredoxin glutathione reductase [Echinococcus granulosus]
          Length = 597

 Score =  458 bits (1179), Expect = e-127
 Identities = 241/484 (49%), Positives = 326/484 (67%), Gaps = 18/484 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYD+V+IGGGSGGLA +KE+AK G KV +LD+V P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 108 YDYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNVGCIPKKLM 167

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           HQ++L+   + +D+K+FGW V +   DW +M++ +  +I ++NF Y+  + +  VKY N 
Sbjct: 168 HQAALLNHYM-EDAKSFGWDVDKGPHDWVKMVEGIQDHIHALNFGYRSSMMNANVKYLNA 226

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEAP 180
           LG  +D HT++  + +   K +TT  +++A G RP+     G  +  I+SDD+F     P
Sbjct: 227 LGEIVDPHTIKTTNKQGIVKNITTNTIIVATGERPRYPPIPGAKEYGITSDDLFTLDHNP 286

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTL VGASYV+LECAGF+  +G DV +MVRSI LRGFDQ MA  I +++  +  ++F+R
Sbjct: 287 GKTLCVGASYVSLECAGFLSSIGCDVTVMVRSIFLRGFDQQMAGLISDYI-AKYGVKFVR 345

Query: 241 GCVPQSIMKL-----ENGQLL---VKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKA 292
            CVP S+  L     E+G+L    V+    DG   ++ F+TVL A GRDP    +GL   
Sbjct: 346 PCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDPCTTNIGLQNV 405

Query: 293 GVKLNPKTGRIWVENEQ-TSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLM 350
            VK     GR+ V++E+ T+ PN+YAIGDV +A  +LTP+AIQAG+ LARRLY  +    
Sbjct: 406 DVKTT--NGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARRLYTADDCRT 463

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DY  V T VFTP+EYGC GLSEE +I KFGEDN+E++H  F PLEW++    RP  ++CY
Sbjct: 464 DYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPH--RP-DNTCY 520

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
            K+I +K  D  VVGFH  GPNAGEVTQ   +AM LG   +     +GIHPT +E FTTL
Sbjct: 521 AKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHPTCSETFTTL 580

Query: 471 EVTK 474
            VTK
Sbjct: 581 RVTK 584


>gb|AAN63051.1| thioredoxin glutathione reductase [Echinococcus granulosus]
          Length = 624

 Score =  458 bits (1179), Expect = e-127
 Identities = 241/484 (49%), Positives = 326/484 (67%), Gaps = 18/484 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYD+V+IGGGSGGLA +KE+AK G KV +LD+V P+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 135 YDYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNVGCIPKKLM 194

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           HQ++L+   + +D+K+FGW V +   DW +M++ +  +I ++NF Y+  + +  VKY N 
Sbjct: 195 HQAALLNHYM-EDAKSFGWDVDKGPHDWVKMVEGIQDHIHALNFGYRSSMMNANVKYLNA 253

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEAP 180
           LG  +D HT++  + +   K +TT  +++A G RP+     G  +  I+SDD+F     P
Sbjct: 254 LGEIVDPHTIKTTNKQGIVKNITTNTIIVATGERPRYPPIPGAKEYGITSDDLFTLDHNP 313

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTL VGASYV+LECAGF+  +G DV +MVRSI LRGFDQ MA  I +++  +  ++F+R
Sbjct: 314 GKTLCVGASYVSLECAGFLSSIGCDVTVMVRSIFLRGFDQQMAGLISDYI-AKYGVKFVR 372

Query: 241 GCVPQSIMKL-----ENGQLL---VKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKA 292
            CVP S+  L     E+G+L    V+    DG   ++ F+TVL A GRDP    +GL   
Sbjct: 373 PCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDPCTTNIGLQNV 432

Query: 293 GVKLNPKTGRIWVENEQ-TSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLM 350
            VK     GR+ V++E+ T+ PN+YAIGDV +A  +LTP+AIQAG+ LARRLY  +    
Sbjct: 433 DVKTT--NGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARRLYTADDCRT 490

Query: 351 DYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCY 410
           DY  V T VFTP+EYGC GLSEE +I KFGEDN+E++H  F PLEW++    RP  ++CY
Sbjct: 491 DYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPH--RP-DNTCY 547

Query: 411 VKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTL 470
            K+I +K  D  VVGFH  GPNAGEVTQ   +AM LG   +     +GIHPT +E FTTL
Sbjct: 548 AKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHPTCSETFTTL 607

Query: 471 EVTK 474
            VTK
Sbjct: 608 RVTK 611


>emb|CAM96615.1| thioredoxin-glutathione reductase [Fasciola hepatica]
          Length = 598

 Score =  457 bits (1176), Expect = e-126
 Identities = 243/486 (50%), Positives = 320/486 (65%), Gaps = 18/486 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYDLVVIGGGSGGLA SKEAA++G K  V D+V P+   T+ GLGGTCVNVGCIPKKL
Sbjct: 106 TYDYDLVVIGGGSGGLAASKEAARFGAKTAVFDFVVPTPQDTTRGLGGTCVNVGCIPKKL 165

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           MHQ++L+ E +  DS  FGW    +    DWAQ+++++ ++I S+N+ Y+ +LR   V+Y
Sbjct: 166 MHQAALLREGM-PDSVHFGWKWDPEKIEHDWAQIVENIGNHIHSLNWGYRTQLRSINVEY 224

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
            N     +D HT++     K T TVT + +++A G RP+     G  + AI+SDD+FW  
Sbjct: 225 VNAFAEVVDPHTIKYTKKNKETGTVTAKVIILATGERPRYPGIPGDKEYAITSDDLFWLP 284

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGASYVALECAGF+   G+D  +MVRSI LRGFDQ MAD IGE+M+ E   +
Sbjct: 285 YPPGKTLVVGASYVALECAGFLTRFGFDTTVMVRSIFLRGFDQQMADMIGEYMK-EHGTK 343

Query: 238 FIRGCVPQSIMKLE--------NGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGL 289
           F+R CVP +I ++E         G   VK    +GE     F+T++ A GRDP   +  +
Sbjct: 344 FVRSCVPTAIEEIEARDKENQKPGLYRVKGKYENGEEFVGEFNTIVMAIGRDPTWDRKAM 403

Query: 290 DKAGVKLNPKTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETT 348
           +  G+KL+     I  +NEQ+S  ++YAIGD++   P+LTPVAI AGR LARRLY  +  
Sbjct: 404 ESVGLKLDKAKRVICADNEQSSVDSIYAIGDIVSGKPQLTPVAIHAGRYLARRLYAGDIE 463

Query: 349 LMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASS 408
           L DY  V T +FTPIEYG CGLSEE +I K+G++N+E+YH +F PLEW++    RP    
Sbjct: 464 LTDYVNVPTTIFTPIEYGACGLSEEDAITKYGKENIEVYHSHFIPLEWTVPH--RP--ED 519

Query: 409 CYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFT 468
            Y K+IC KS  + V+G H LGPNAGE+TQ   +AMK G T       +GIHPT  E FT
Sbjct: 520 GYAKIICLKSDSERVIGLHVLGPNAGEMTQGFSVAMKAGATKADFDRTIGIHPTCFEGFT 579

Query: 469 TLEVTK 474
           T+ VTK
Sbjct: 580 TMHVTK 585


>ref|XP_002028236.1| GL23230 [Drosophila persimilis]
 gb|EDW39395.1| GL23230 [Drosophila persimilis]
          Length = 512

 Score =  456 bits (1174), Expect = e-126
 Identities = 243/481 (50%), Positives = 331/481 (68%), Gaps = 17/481 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEA   G +V   DYVKP+ VGT WGLGGTCVNVGCIPKKLM
Sbjct: 28  YDYDLVVLGGGSAGLACAKEAVDNGARVLCFDYVKPTPVGTKWGLGGTCVNVGCIPKKLM 87

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V +Q    DW +++KSV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 88  HQASLLGEAVH-EAVAYGWNVNDQNIKPDWQKLVKSVQNHIKSVNWVTRVDLRDKKVEYV 146

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGGDLAISSDDIFWRK 177
           N +G+F+D HT+E +  K G K   T + VV+AVGGRP+ P      +  I+SDDIF   
Sbjct: 147 NSMGAFVDPHTIE-YSVKGGPKQQATAEYVVVAVGGRPRYPPILGATEFGITSDDIFSYD 205

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG+TLVVGA YV LECA F+KG+GYD  +MVRSI+LRGFD+ M++ + E M  E  ++
Sbjct: 206 REPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSELL-EAMMSERGVQ 264

Query: 238 FIRGCVPQSIMKLENGQLLVKW--TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           F+   +P S+ +  +G+LLVK+  TT + E   + FDTVL A GR   +  L L  AGV+
Sbjct: 265 FLHTTIPSSVERQGDGRLLVKYRNTTTEKED-SDVFDTVLWAIGRKGLIEDLNLPAAGVE 323

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYD 353
              K  +I V++ E T+ P+++A+GD+I   PEL+PVAI +GRLLARRL+     LMDY 
Sbjct: 324 --TKNDKIVVDSTEATNVPHIFAVGDIIHGRPELSPVAILSGRLLARRLFAGSKQLMDYA 381

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EY C G+SEE +I+  G DN+E++H  + P E+ +    R +   CY+K 
Sbjct: 382 DVATTVFTPLEYSCVGMSEEMAIQTHGPDNIEVFHGYYKPTEFFI---PRKSVRHCYLKA 438

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           + + + D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +T
Sbjct: 439 VAEITGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSIT 498

Query: 474 K 474
           K
Sbjct: 499 K 499


>ref|XP_002115731.1| hypothetical protein TRIADDRAFT_50766 [Trichoplax adhaerens]
 gb|EDV21583.1| hypothetical protein TRIADDRAFT_50766 [Trichoplax adhaerens]
          Length = 522

 Score =  456 bits (1173), Expect = e-126
 Identities = 238/480 (49%), Positives = 330/480 (68%), Gaps = 18/480 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T  +DLVVIGGGSGGLAC+KEA+  GKKV ++D+V+P++ GT+WGLGGTCVNVGCIPKKL
Sbjct: 44  TAHFDLVVIGGGSGGLACAKEASTLGKKVAIVDHVEPTVHGTTWGLGGTCVNVGCIPKKL 103

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFD--WAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           MHQ++L+G+++ +D++ +GW +   +++  W  +   V +YIKS+N+ Y+V+L++KK+ Y
Sbjct: 104 MHQAALLGQSL-QDARHYGWQLPSSSYEHSWETLRDGVRNYIKSLNWGYRVQLKNKKIDY 162

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWR 176
            N  G+F+  H +++   K G       + VIAVGGRP+ P    G  + AISSDD+F  
Sbjct: 163 LNGKGTFLSRHEIKV-DLKSG------NNYVIAVGGRPRIPNNIPGAREYAISSDDLFSL 215

Query: 177 KEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKI 236
            +APGK L++GA Y+ALECAGF+ G+G D  IM RSI LR FDQDM   I E ME E  I
Sbjct: 216 DKAPGKVLIIGAGYIALECAGFLSGIGCDTSIMARSICLRSFDQDMVSLITENME-EEGI 274

Query: 237 EFIRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
            FIR   P  + K    ++ V++  T  G      +D V+ A GRDP  A L L+ A VK
Sbjct: 275 SFIRKSQPLRMSKTTGDKIEVEYENTETGLKSIGLYDNVMFAVGRDPTTASLNLNVANVK 334

Query: 296 LNPKTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           ++P++ +I  ENEQT+ PN+YAIGDV+   PELTPVAI AGRLLARRL N  +T MDY +
Sbjct: 335 IHPESKKILAENEQTTCPNIYAIGDVLHGKPELTPVAIHAGRLLARRLCNVSSTQMDYAQ 394

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           + T +FTP+EYGC G+SE  + E + ++N+E+YH  + PLE+++   T+     CYVK +
Sbjct: 395 IPTTIFTPLEYGCIGISEAKAEELYFKENIEVYHAFYLPLEYAI---TQRVCKQCYVKAV 451

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           C KS ++ ++G H+LGPNAGEV Q    AMK G TYDQ+VN +GIHPT AE    L +++
Sbjct: 452 CLKSDNERIIGLHFLGPNAGEVIQGFATAMKCGVTYDQVVNTIGIHPTCAEEVVKLRISR 511


>ref|XP_001415584.1| thioredoxin reductase, putative selenoenzyme? [Ostreococcus
           lucimarinus CCE9901]
 gb|ABO93876.1| thioredoxin reductase, putative selenoenzyme [Ostreococcus
           lucimarinus CCE9901]
          Length = 503

 Score =  456 bits (1172), Expect = e-126
 Identities = 242/483 (50%), Positives = 322/483 (66%), Gaps = 12/483 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           ++YD+VVIGGGSGGLA +KEAAK+G K   LD+VKPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 12  HEYDVVVIGGGSGGLAAAKEAAKHGAKTMCLDFVKPSPAGTTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           HQ+ ++GE+   D++ +GW +  +  DW +M++ + ++I S+NF Y+  LR+K V Y N 
Sbjct: 72  HQAGILGESF-SDAREYGWKLASEGHDWGKMVEQIQNHIGSLNFGYRTTLREKNVTYVNA 130

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRKEAP 180
            G F D +T+         + +TT  VV+AVGGRP  P A    +  I+SDDIF + EAP
Sbjct: 131 YGRFKDKNTIIATKKNGQEQVITTDKVVVAVGGRPSYPDAPGAKECCITSDDIFSKPEAP 190

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTL VGASY++LE AGF+  +G+D  + +RSI LRGFDQ++A+KI ++M  E    F+R
Sbjct: 191 GKTLCVGASYISLETAGFLTALGFDTAVAIRSIPLRGFDQEVAEKIVKYMG-EHGTRFLR 249

Query: 241 GCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
              P    K E+G++ V +  T  G   EE FDTV+ A GRD     L L  AGV+ NPK
Sbjct: 250 DSQPTVFEKQEDGKIKVTFENTMFGNTFEETFDTVVCAVGRDAVTEGLDLPAAGVEFNPK 309

Query: 300 TGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNE--TTLMDYDKVC 356
            G+I   +EQT+  N+YAIGDV+D   ELTPVAI+AG  L RR++ +      M+YD V 
Sbjct: 310 NGKIACVDEQTNVDNIYAIGDVLDTRQELTPVAIKAGVRLMRRVFADTPYKEKMNYDLVP 369

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAA-----SSCYV 411
           T VFTP+EYG  G+SEE ++E +G DN+E Y   F PLEW+L+            ++CYV
Sbjct: 370 TTVFTPLEYGTIGMSEELAVETYGADNVECYVSYFKPLEWTLNHEEHKGVPVRGDNACYV 429

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+I + + D+ VVGFHYLGPNAGEVTQ   +AMK+G T       VGIHPT +E FT LE
Sbjct: 430 KLITNLADDERVVGFHYLGPNAGEVTQGYAVAMKMGATKKDFDETVGIHPTVSEEFTILE 489

Query: 472 VTK 474
           +TK
Sbjct: 490 ITK 492


>ref|XP_001352389.2| GA10979 [Drosophila pseudoobscura pseudoobscura]
 gb|EAL29885.2| GA10979 [Drosophila pseudoobscura pseudoobscura]
          Length = 512

 Score =  455 bits (1171), Expect = e-126
 Identities = 243/481 (50%), Positives = 330/481 (68%), Gaps = 17/481 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEA   G +V   DYVKP+ VGT WGLGGTCVNVGCIPKKLM
Sbjct: 28  YDYDLVVLGGGSAGLACAKEAVDNGARVLCFDYVKPTPVGTKWGLGGTCVNVGCIPKKLM 87

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V +Q    DW +++KSV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 88  HQASLLGEAVH-EAVAYGWNVNDQNIKPDWQKLVKSVQNHIKSVNWVTRVDLRDKKVEYV 146

Query: 120 NLLGSFIDAHTLELWHPKKGTK-TVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRK 177
           N +G+F+D HT+E +  K G K   T   VV+AVGGRP+ P      +  I+SDDIF   
Sbjct: 147 NSMGTFVDPHTIE-YSVKGGPKQQATAAYVVVAVGGRPRYPPILGATEFGITSDDIFSYD 205

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG+TLVVGA YV LECA F+KG+GYD  +MVRSI+LRGFD+ M++ + E M  E  ++
Sbjct: 206 REPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSELL-EAMMSERGVQ 264

Query: 238 FIRGCVPQSIMKLENGQLLVKW--TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           F+   +P S+ +  +G+LLVK+  TT + E   + FDTVL A GR   +  L L  AGV+
Sbjct: 265 FLHTTIPSSVERQGDGRLLVKYRNTTTEKED-SDVFDTVLWAIGRKGLIEDLNLPAAGVE 323

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYD 353
              K  +I V++ E T+ P+++A+GD+I   PEL+PVAI +GRLLARRL+     LMDY 
Sbjct: 324 --TKNDKIVVDSKEATNVPHIFAVGDIIHGRPELSPVAILSGRLLARRLFAGSKQLMDYA 381

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTP+EY C G+SEE +I+  G DN+E++H  + P E+ +    R +   CY+K 
Sbjct: 382 DVATTVFTPLEYSCVGMSEEMAIQTHGPDNIEVFHGYYKPTEFFI---PRKSVRHCYLKA 438

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           + + + D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +T
Sbjct: 439 VAEITGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSIT 498

Query: 474 K 474
           K
Sbjct: 499 K 499


>ref|XP_002040924.1| GM22453 [Drosophila sechellia]
 gb|EDW44477.1| GM22453 [Drosophila sechellia]
          Length = 516

 Score =  455 bits (1171), Expect = e-126
 Identities = 243/483 (50%), Positives = 333/483 (68%), Gaps = 20/483 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+ VGT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V ++    DW ++++SV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 91  HQASLLGEAVH-EAVAYGWNVDDKNIRPDWGKLVRSVQNHIKSVNWVTRVDLRDKKVEYV 149

Query: 120 NLLGSFIDAHTLE-LWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N +GSF D+HT+E +  P    + VT+  VV+AVGGRP+     G  +L I+SDDIF  +
Sbjct: 150 NSMGSFRDSHTIEYVAMPDAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYE 209

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG+TLVVGA YV LECA F+KG+GY+  +MVRSI+LRGFD+ M++ +   M  E  I 
Sbjct: 210 REPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TERGIP 268

Query: 238 FIRGCVPQSIMKLENGQLLVKW----TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           F+   +P+++ +  +G+LLV++    T  DG    + FDTVL A GR   +  L L+ AG
Sbjct: 269 FLGTTIPKAVERQADGRLLVRYRNTTTQMDG---SDVFDTVLWAIGRKGLIEDLNLEAAG 325

Query: 294 VKLNPKTGRIWVE-NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK +    +I V+  E TS P+++A+GD+I   PELTPVAI +GRLLARRL+   T LMD
Sbjct: 326 VKTH--DDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMD 383

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EY C G+SEE +IE  G DN+E++H  + P E+ +    + +   CY+
Sbjct: 384 YADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFI---PQKSVRHCYL 440

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K + + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L 
Sbjct: 441 KAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLS 500

Query: 472 VTK 474
           +TK
Sbjct: 501 ITK 503


>gb|ADY41259.1| Thioredoxin reductase 1 [Ascaris suum]
          Length = 685

 Score =  455 bits (1170), Expect = e-126
 Identities = 247/487 (50%), Positives = 329/487 (67%), Gaps = 20/487 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           ++YDLVVIGGGSGGLA +KEAA+ GKKV  LD+VKPS++GT+WGLGGTCVNVGCIPKKLM
Sbjct: 194 HNYDLVVIGGGSGGLAAAKEAARLGKKVLCLDFVKPSVMGTTWGLGGTCVNVGCIPKKLM 253

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ++L+GE I  D+K FGW +  G+   +W +M  ++  +I S+N+ Y+V+LR++ V Y 
Sbjct: 254 HQAALLGEYI-GDAKKFGWEIPKGDMKLNWEKMRNAIQDHIASLNWGYRVQLRERSVTYS 312

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRKE 178
           N  G F  +H L   + KK  + VT    +IA G RP+ P      +  ISSDD+F    
Sbjct: 313 NAYGVFTGSHELTTTNKKKKVEKVTADRFIIATGLRPRYPDVPGAKECCISSDDLFSLTY 372

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL VGASYV+LECAGF+KG+G DV +MVRSILLRGFDQDMA++I   M +  +I+F
Sbjct: 373 NPGKTLCVGASYVSLECAGFLKGIGNDVTVMVRSILLRGFDQDMAERIRRHM-MTHEIKF 431

Query: 239 IRGCVPQSIMKLEN------GQLLVKW--TTADGE--ACEEAFDTVLNATGRDPDVAKLG 288
           I   VP    ++E       G + V W  T+ DGE   C + F+TVL A GRD    ++G
Sbjct: 432 I-NAVPTKYERIEEPADDKPGLVRVYWEETSQDGEKTPCTQDFNTVLMAIGRDAVTDEMG 490

Query: 289 LDKAGVKLNPKTGRIWVENEQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNET 347
           L+  GV+   K+G+I    EQ++ P VY IGDV++  PELTPVAIQAGR+L RRL    +
Sbjct: 491 LELVGVE-RTKSGKIVGRREQSTCPYVYGIGDVLNGCPELTPVAIQAGRVLMRRLITGNS 549

Query: 348 TLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAAS 407
            L +YD+V T VFTP+EYGCCGL+EEA+I+K+G++N+ +YH  F PLE+S+    R   S
Sbjct: 550 ELTEYDQVPTTVFTPLEYGCCGLAEEAAIQKYGKENINVYHNVFIPLEYSVPE--RVENS 607

Query: 408 SCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIF 467
            CY K+IC K+    V+G+H L PNAGE+TQ   + +KL         ++GIHPT AE  
Sbjct: 608 HCYCKLICLKTEQDLVLGYHILAPNAGEITQGFAIGLKLKAKKADFDRLIGIHPTVAENL 667

Query: 468 TTLEVTK 474
           TTL + K
Sbjct: 668 TTLTLVK 674


>ref|XP_002086704.1| GE23284 [Drosophila yakuba]
 gb|EDX00106.1| GE23284 [Drosophila yakuba]
          Length = 516

 Score =  454 bits (1168), Expect = e-125
 Identities = 241/480 (50%), Positives = 331/480 (68%), Gaps = 14/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+ VGT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V +Q    DW ++++SV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 91  HQASLLGEAVH-EAVAYGWNVDDQNLRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYV 149

Query: 120 NLLGSFIDAHTLE-LWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N + SF D+HT+E +  P    + VT+  VV+AVGGRP+     G  +L I+SDDIF  +
Sbjct: 150 NSMCSFRDSHTIEYVAMPGAENRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYE 209

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG+TLVVGA YV LECA F+KG+GY+  +MVRSI+LRGFD+ M++ +   M  E  I 
Sbjct: 210 REPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TERGIP 268

Query: 238 FIRGCVPQSIMKLENGQLLVKW-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           F+   +P+++ +  +G+LLV++  T   +   + FDTVL A GR   +  L L+ AGVK 
Sbjct: 269 FLGTTIPKAVERQADGRLLVRYHNTTTQKDGSDVFDTVLWAIGRKGLIEDLNLEAAGVKT 328

Query: 297 NPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           +    +I V+  E TS P+++A+GD+I   PELTPVAI +GRLLARRL+   T LMDY  
Sbjct: 329 H--DDKIVVDGAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYAD 386

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EY C G+SEE +IE  G DN+E++H  + P E+ +    + +   CY+K +
Sbjct: 387 VATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFI---PQKSVRHCYLKAV 443

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L +TK
Sbjct: 444 AEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSITK 503


>dbj|BAE72986.1| hypothetical protein [Macaca fascicularis]
          Length = 499

 Score =  454 bits (1168), Expect = e-125
 Identities = 236/473 (49%), Positives = 326/473 (68%), Gaps = 13/473 (2%)

Query: 9   IGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQSSLIG 68
           + GG  G A    AA+ G+KV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ++L+G
Sbjct: 22  VAGGVRGAARGAAAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLG 81

Query: 69  ETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLLGSFID 127
             I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+  SF+D
Sbjct: 82  GLI-QDAPHYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVD 140

Query: 128 AHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAPGKTL 184
            HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE+PGKTL
Sbjct: 141 EHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTL 199

Query: 185 VVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIRGCVP 244
           VVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E M      +F+RGC P
Sbjct: 200 VVGASYVALECAGFLTGIGLDTTVMIRSIPLRGFDQQMSSMVIEHMASHGT-QFLRGCAP 258

Query: 245 QSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPKTGRI 303
             + +L +G L V W     G+     FDTVL A GR PD   L L+KAGV  +P T +I
Sbjct: 259 SRVRRLPDGHLQVTWEDCTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKI 318

Query: 304 WVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCTAVFT 361
            V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V T VFT
Sbjct: 319 LVDSREGTSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFT 378

Query: 362 PIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKSRDK 421
           P+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C +   +
Sbjct: 379 PLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVCLREPPQ 435

Query: 422 YVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            V+G H+LGPNAGEVTQ + L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 436 LVLGLHFLGPNAGEVTQGLALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 488


>emb|CBJ26963.1| Electron donor (NADH / NADPH)-dependent reductase [Ectocarpus
           siliculosus]
          Length = 520

 Score =  453 bits (1165), Expect = e-125
 Identities = 248/501 (49%), Positives = 330/501 (65%), Gaps = 35/501 (6%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL VIGGGSGG+A +K+AA YGKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 10  SYDYDLAVIGGGSGGMAVAKKAASYGKKVVLFDFVKPSPQGTKWGLGGTCVNVGCVPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH + L+G  +H D+KAFGW VG    DW  M+++V +++K +NF+Y+V L+  +V Y N
Sbjct: 70  MHYAGLLGAGMH-DAKAFGWKVGNPEHDWEAMVETVQNHVKMLNFRYRVGLKSAQVTYVN 128

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
            L      H +      K TK    R V+IAVGGRP  P    G  + A++SDD+F  + 
Sbjct: 129 GLARLTGPHEVTCEKRGKETKHTAAR-VIIAVGGRPVIPDDVPGAREHALTSDDLFSLRT 187

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASY+ALECAGFM+ +G DV + VRSILLRGFDQ +A+K+G+ M+ +  ++F
Sbjct: 188 SPGKTLVVGASYIALECAGFMRELGLDVTVAVRSILLRGFDQQVAEKLGDVMK-DLGVKF 246

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEE----AFDTVLNATGRDPDVAKLGLDKAGV 294
           +R  VP  I K  +G+L V  T  D ++ EE     +D+V  ATGR  D + +GL+ AGV
Sbjct: 247 VRPAVPSKIEKTSDGKLEV--TLVDSKSGEEVSKGTYDSVFYATGRKADTSGIGLETAGV 304

Query: 295 KLNPKTGRIWVENEQTSTPNVYAIGDVIDA-----------PELTPVAIQAGRLLARRLY 343
           K+NP  G+I VENEQT+  +++AIGD               PELTPVA+QAG LLA RLY
Sbjct: 305 KVNP-NGKIPVENEQTNVEHIFAIGDCTSVDVMFHESHWANPELTPVAVQAGELLASRLY 363

Query: 344 NNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR 403
              T  MDY  V TAVFTP+EYGCCGLSEE +I  +GED++E Y   F  LE S +   +
Sbjct: 364 ARATEQMDYSLVATAVFTPVEYGCCGLSEEDAIRLYGEDDVETYLFGFGTLEQSAAHRVK 423

Query: 404 ----------PAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQM 453
                     PA +    K++C KS+ + V+GFH++GPNAGE+TQ  GLA++LG      
Sbjct: 424 HVEGEEEDDMPATN--LSKLVCLKSQGEKVIGFHFVGPNAGEITQGFGLAVRLGAKKSDF 481

Query: 454 VNVVGIHPTTAEIFTTLEVTK 474
             +VGIHP+ AE F  + +T+
Sbjct: 482 NKLVGIHPSDAESFCAMGITR 502


>ref|XP_003056182.1| thioredoxin-disufide reductase [Micromonas pusilla CCMP1545]
 gb|EEH59558.1| thioredoxin-disufide reductase [Micromonas pusilla CCMP1545]
          Length = 497

 Score =  453 bits (1165), Expect = e-125
 Identities = 239/481 (49%), Positives = 309/481 (64%), Gaps = 10/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLA +KEAAK G KV  LD+VKPS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 8   FDYDLVVVGGGSGGLATAKEAAKLGAKVACLDFVKPSPAGTSWGLGGTCVNVGCIPKKLM 67

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           HQ+ ++GE+   D++ FGW +     DW++M+  +  +I S+NF Y+  LRD  V Y N 
Sbjct: 68  HQAGILGESF-SDAREFGWKLRSDGHDWSKMVNGIQDHIGSLNFGYRTALRDNNVTYINA 126

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEAP 180
            GSFID HT+           +T+   VIAVGGRP  L   G  +  I+SDD+F   + P
Sbjct: 127 FGSFIDEHTITATKKNGKVDKITSERFVIAVGGRPSYLDVPGARECCITSDDVFSLPKPP 186

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTL VGASY++LE AGF+  +GYD  + +RS+ LRGFD ++A+ +   ME      F+R
Sbjct: 187 GKTLCVGASYISLETAGFLTALGYDTTVAIRSVPLRGFDSEIAEMVVSHME-RHGTNFMR 245

Query: 241 GCVPQSIMKLENGQLLVK-WTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
              P +  K  +GQ+ V    T  G      FDTV+ A GR      L L  AGV +NPK
Sbjct: 246 DSQPVAFEKAADGQIKVSIKNTVFGSEFAAVFDTVILAVGRMAVTEGLNLATAGVHVNPK 305

Query: 300 TGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCTA 358
            G+I   +E T+ P+++AIG V+D   ELTPVAI+AG  LARRLY+  T  MDY  V T 
Sbjct: 306 NGKIPAVDEVTNVPHIFAIGYVLDTRQELTPVAIKAGVRLARRLYSGSTEKMDYSLVPTT 365

Query: 359 VFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEW-----SLSSATRPAASSCYVKV 413
           VFTP EYGC G+SEE +IE +GE+N+E+YH  F PLEW     +L        +SCY K+
Sbjct: 366 VFTPQEYGCIGMSEEQAIEMYGEENVEVYHSYFKPLEWTINHEALDGVAHREDNSCYSKL 425

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           I + S D+ V+GFHY+GP+AGEVTQ   +AM++G         VGIHPT +E FTTL +T
Sbjct: 426 ITNLSDDERVIGFHYIGPHAGEVTQGYAVAMRMGAKKRDFDGTVGIHPTVSEEFTTLSIT 485

Query: 474 K 474
           K
Sbjct: 486 K 486


>gb|EAX03014.1| hCG17888, isoform CRA_b [Homo sapiens]
          Length = 473

 Score =  453 bits (1165), Expect = e-125
 Identities = 239/479 (49%), Positives = 325/479 (67%), Gaps = 32/479 (6%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 49

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 50  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 108

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 109 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 167

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 168 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT-RF 226

Query: 239 IRGCVPQSIMKLENGQLLVKWT-TADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 227 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 286

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 287 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 346

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 347 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 403

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 404 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 462


>gb|EAX03013.1| hCG17888, isoform CRA_a [Homo sapiens]
          Length = 503

 Score =  453 bits (1165), Expect = e-125
 Identities = 239/479 (49%), Positives = 325/479 (67%), Gaps = 32/479 (6%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 80  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 138

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 139 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 197

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 198 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT-RF 256

Query: 239 IRGCVPQSIMKLENGQLLVKWT-TADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 257 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 316

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 317 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 376

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 377 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 433

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            +   + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 434 LREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISK 492


>ref|NP_524216.1| thioredoxin reductase 2 [Drosophila melanogaster]
 sp|Q9VNT5|TRXR2_DROME RecName: Full=Thioredoxin reductase 2, mitochondrial; Short=TrxR-2;
           Flags: Precursor
 gb|AAF64152.1|AF236866_1 thioredoxin reductase 2 [Drosophila melanogaster]
 gb|AAF51835.1| thioredoxin reductase 2 [Drosophila melanogaster]
 gb|AAM51940.1| AT28243p [Drosophila melanogaster]
 gb|ACL87413.1| Trxr-2-PA [synthetic construct]
          Length = 516

 Score =  452 bits (1163), Expect = e-125
 Identities = 242/483 (50%), Positives = 331/483 (68%), Gaps = 20/483 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+ VGT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V +     DW ++++SV ++IKS+N+  +V+LRDKKV+Y 
Sbjct: 91  HQASLLGEAVH-EAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYV 149

Query: 120 NLLGSFIDAHTLE-LWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N + +F D+HT+E +  P    + VT+  VV+AVGGRP+     G  +L I+SDDIF  +
Sbjct: 150 NSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYE 209

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG+TLVVGA YV LECA F+KG+GY+  +MVRSI+LRGFD+ M++ +   M  E  I 
Sbjct: 210 REPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TERGIP 268

Query: 238 FIRGCVPQSIMKLENGQLLVKW----TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           F+   +P+++ +  +G+LLV++    T  DG    + FDTVL A GR   +  L LD AG
Sbjct: 269 FLGTTIPKAVERQADGRLLVRYRNTTTQMDG---SDVFDTVLWAIGRKGLIEDLNLDAAG 325

Query: 294 VKLNPKTGRIWVE-NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK +    +I V+  E TS P+++A+GD+I   PELTPVAI +GRLLARRL+   T LMD
Sbjct: 326 VKTH--DDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMD 383

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EY C G+SEE +IE  G DN+E++H  + P E+ +    + +   CY+
Sbjct: 384 YADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFI---PQKSVRHCYL 440

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K + + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L 
Sbjct: 441 KAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLS 500

Query: 472 VTK 474
           +TK
Sbjct: 501 ITK 503


>ref|XP_310514.3| thioredoxin reductase (AGAP000565-PB) [Anopheles gambiae str. PEST]
 emb|CAD70158.1| thioredoxin-disulfide reductase [Anopheles gambiae]
 gb|EAA06298.3| thioredoxin reductase (AGAP000565-PB) [Anopheles gambiae str. PEST]
          Length = 505

 Score =  452 bits (1162), Expect = e-125
 Identities = 246/486 (50%), Positives = 326/486 (67%), Gaps = 18/486 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDLVVIGGGSGGLAC+K+A + G KV VLD+VKPS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 12  YEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT---FDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE IH DS+ +GW + +      DWA + +SV ++IKS+N+  +V+LRD+KV+Y
Sbjct: 72  HQASLLGEAIH-DSQPYGWQLPDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEY 130

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRK 177
            N LG F D HT+      +  + +  + VVIAVGGRP+ P      +  I+SDDIF   
Sbjct: 131 VNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIFSLP 190

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           +APG+TL+VGA Y+ LECAGF+KG+GYDV +MVRSILLRGFDQ MA  +G+ M VE  I 
Sbjct: 191 QAPGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSM-VEKGIR 249

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD--GEAC--EEAFDTVLNATGRDPDVAKLGLDKAG 293
           F     P ++ K  +G+LLV++ T D  G A   E+ FDTVL A GR  +   L L  AG
Sbjct: 250 FHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKLANAG 309

Query: 294 VKL--NPKTGRIWVE--NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETT 348
           V      K+ ++ V+  + +T+ P++YA+GDV+   PELTPVAI AGR++ARRL+     
Sbjct: 310 VVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFGGSEE 369

Query: 349 LMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASS 408
            MDY  V T VFTP+EYGC GLSEEA+    G+D +E+YH  + P E+ +    + +   
Sbjct: 370 RMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFV---PQRSVRY 426

Query: 409 CYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFT 468
           CY+K +  +  ++ V+G H+LGP AGEV Q    A+K G T   + N VGIHPT AE FT
Sbjct: 427 CYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHPTVAEEFT 486

Query: 469 TLEVTK 474
            L +TK
Sbjct: 487 RLAITK 492


>emb|CAD30858.1| thioredoxin reductase [Anopheles gambiae]
          Length = 502

 Score =  452 bits (1162), Expect = e-125
 Identities = 246/486 (50%), Positives = 326/486 (67%), Gaps = 18/486 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDLVVIGGGSGGLAC+K+A + G KV VLD+VKPS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 9   YEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLM 68

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT---FDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE IH DS+ +GW + +      DWA + +SV ++IKS+N+  +V+LRD+KV+Y
Sbjct: 69  HQASLLGEAIH-DSQPYGWQLPDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEY 127

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRK 177
            N LG F D HT+      +  + +  + VVIAVGGRP+ P      +  I+SDDIF   
Sbjct: 128 VNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIFSLP 187

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           +APG+TL+VGA Y+ LECAGF+KG+GYDV +MVRSILLRGFDQ MA  +G+ M VE  I 
Sbjct: 188 QAPGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSM-VEKGIR 246

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD--GEAC--EEAFDTVLNATGRDPDVAKLGLDKAG 293
           F     P ++ K  +G+LLV++ T D  G A   E+ FDTVL A GR  +   L L  AG
Sbjct: 247 FHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKLANAG 306

Query: 294 VKL--NPKTGRIWVE--NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETT 348
           V      K+ ++ V+  + +T+ P++YA+GDV+   PELTPVAI AGR++ARRL+     
Sbjct: 307 VVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFGGSEE 366

Query: 349 LMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASS 408
            MDY  V T VFTP+EYGC GLSEEA+    G+D +E+YH  + P E+ +    + +   
Sbjct: 367 RMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFV---PQRSVRY 423

Query: 409 CYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFT 468
           CY+K +  +  ++ V+G H+LGP AGEV Q    A+K G T   + N VGIHPT AE FT
Sbjct: 424 CYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHPTVAEEFT 483

Query: 469 TLEVTK 474
            L +TK
Sbjct: 484 RLAITK 489


>ref|XP_001237264.1| AGAP000565-PA [Anopheles gambiae str. PEST]
 emb|CAD70159.1| thioredoxin-disulfide reductase [Anopheles gambiae]
 gb|EAU77244.1| AGAP000565-PA [Anopheles gambiae str. PEST]
          Length = 529

 Score =  452 bits (1162), Expect = e-125
 Identities = 246/486 (50%), Positives = 326/486 (67%), Gaps = 18/486 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDLVVIGGGSGGLAC+K+A + G KV VLD+VKPS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 36  YEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLM 95

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT---FDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           HQ+SL+GE IH DS+ +GW + +      DWA + +SV ++IKS+N+  +V+LRD+KV+Y
Sbjct: 96  HQASLLGEAIH-DSQPYGWQLPDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEY 154

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRK 177
            N LG F D HT+      +  + +  + VVIAVGGRP+ P      +  I+SDDIF   
Sbjct: 155 VNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIFSLP 214

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           +APG+TL+VGA Y+ LECAGF+KG+GYDV +MVRSILLRGFDQ MA  +G+ M VE  I 
Sbjct: 215 QAPGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSM-VEKGIR 273

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTAD--GEAC--EEAFDTVLNATGRDPDVAKLGLDKAG 293
           F     P ++ K  +G+LLV++ T D  G A   E+ FDTVL A GR  +   L L  AG
Sbjct: 274 FHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKLANAG 333

Query: 294 VKL--NPKTGRIWVE--NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETT 348
           V      K+ ++ V+  + +T+ P++YA+GDV+   PELTPVAI AGR++ARRL+     
Sbjct: 334 VVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFGGSEE 393

Query: 349 LMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASS 408
            MDY  V T VFTP+EYGC GLSEEA+    G+D +E+YH  + P E+ +    + +   
Sbjct: 394 RMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFV---PQRSVRY 450

Query: 409 CYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFT 468
           CY+K +  +  ++ V+G H+LGP AGEV Q    A+K G T   + N VGIHPT AE FT
Sbjct: 451 CYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHPTVAEEFT 510

Query: 469 TLEVTK 474
            L +TK
Sbjct: 511 RLAITK 516


>ref|XP_002674924.1| thioredoxin reductase [Naegleria gruberi]
 gb|EFC42180.1| thioredoxin reductase [Naegleria gruberi]
          Length = 500

 Score =  451 bits (1159), Expect = e-124
 Identities = 254/486 (52%), Positives = 326/486 (67%), Gaps = 27/486 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGG+A +KEA   G KV V DY+KPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 17  YDYDLIVIGGGSGGIALAKEANALGAKVAVFDYIKPSPQGTTWGLGGTCVNVGCIPKKLM 76

Query: 62  HQSSLIGETIHKDSKAFGWT--VGEQT-----FDWAQMLKSVNSYIKSINFKYKVELRDK 114
           H ++LIG+   +D  AFGWT  VG  T       W ++++ V  +I  +NFKY+ +LR K
Sbjct: 77  HTAALIGDR-SQDGTAFGWTNSVGHGTERKPHHQWGKLVEMVQDHIHGLNFKYRTDLRKK 135

Query: 115 KVKYENLLGSFIDAHTLELWHPKKGT---KTVTTRDVVIAVGGRPKPLACEGG-DLAISS 170
            + Y NL  SFIDAHT+E    K G    K  T R   IAVGGRP      G  +  ISS
Sbjct: 136 GITYHNLYASFIDAHTVE--GKKDGQEEGKRFTARRFAIAVGGRPLYPDIPGAKEYCISS 193

Query: 171 DDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFM 230
           DDIF  ++ PGK+LVVGASYVALEC GF+ G+G D  IMVRS+ LRGFD++ ADKI   M
Sbjct: 194 DDIFSMEKEPGKSLVVGASYVALECGGFLHGIGNDTTIMVRSVPLRGFDRECADKIVNVM 253

Query: 231 EVESKIEFIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGL 289
             E  ++F + CVP S+ KLE+G+L V++   +  E   E FDTVL ATGR      L L
Sbjct: 254 SDEG-VKFYQPCVPLSVNKLESGKLSVEYENVETKEKKTEEFDTVLFATGRYALTQALNL 312

Query: 290 DKAGVKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNET 347
           +  GVK + K G+I+V   EQ+S P++YAIGDVI    ELTPVAI+AG+LLA RLYN+  
Sbjct: 313 ENIGVKTD-KVGKIFVNKYEQSSVPHIYAIGDVIVGGLELTPVAIKAGKLLAARLYNSSK 371

Query: 348 TLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAAS 407
            +MDYDKV T VFTP+EYG CGL+EE +++++G +NL IY +++  LE+       P A 
Sbjct: 372 KMMDYDKVPTTVFTPVEYGSCGLTEEEAVKRYGAENLTIYKKSYYVLEY------EPPAR 425

Query: 408 SC--YVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
            C  +VK+IC++  ++ V+GFHY+GPNAGEVTQ   +AM+   T +   + VGIHPT AE
Sbjct: 426 ECQAFVKLICNELDNERVLGFHYVGPNAGEVTQGFAVAMRCNATKEDFDDTVGIHPTCAE 485

Query: 466 IFTTLE 471
               LE
Sbjct: 486 TIVKLE 491


>gb|EFB29376.1| hypothetical protein PANDA_009396 [Ailuropoda melanoleuca]
          Length = 464

 Score =  449 bits (1156), Expect = e-124
 Identities = 233/459 (50%), Positives = 317/459 (69%), Gaps = 12/459 (2%)

Query: 22  AAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQSSLIGETIHKDSKAFGWT 81
           AA+ GKKV V+DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ++L+G  I +D+  +GW 
Sbjct: 1   AAQLGKKVAVVDYVEPSPRGTRWGLGGTCVNVGCIPKKLMHQAALLGGMI-RDAPHYGWA 59

Query: 82  VGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLLGSFIDAHTLELWHPKKGTK 141
           V     DW  M ++V +Y+KS+N+ ++V+L+D+KVKY N+  SF++ HT+     K G +
Sbjct: 60  VQPVLHDWRTMAEAVQNYVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTV-CGVAKDGKE 118

Query: 142 TVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAPGKTLVVGASYVALECAGF 198
           T+ + + +VIA GGRPK P   EG  +  I+SDDIFW KE+PGKTLVVGASYVALECAGF
Sbjct: 119 TLLSAEHIVIATGGRPKYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGF 178

Query: 199 MKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIRGCVPQSIMKLENGQLLVK 258
           + G+G D  +M+RSI LRGFDQ M+  + E+M  +    F+RGC P  +  L +GQL V 
Sbjct: 179 LTGLGLDTTVMIRSIPLRGFDQQMSSLVTEYMASQG-TRFLRGCTPSRVRGLPDGQLQVT 237

Query: 259 W-TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPKTGRIWVE-NEQTSTPNVY 316
           W     G+     F+TVL A GR P+   L L+KAGV  NP + +I V+  E TS P++Y
Sbjct: 238 WEDLTSGKEDMGTFNTVLWAIGRIPETRSLNLEKAGVNTNPNSQKILVDAQETTSVPHIY 297

Query: 317 AIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCTAVFTPIEYGCCGLSEEAS 375
           AIGD+ +  PELTP AI AG+LLA+RL    + +MDYD V T VFTP+EYGC GLSEE +
Sbjct: 298 AIGDIAEGRPELTPTAIMAGKLLAQRLCGQSSDVMDYDNVPTTVFTPLEYGCVGLSEEEA 357

Query: 376 IEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKSRDKYVVGFHYLGPNAGE 435
           + + GE+++E+YH  + PLE++++      AS CY+K++C +   + V+G H+LGPNAGE
Sbjct: 358 VARHGEEHVEVYHAYYKPLEFTVAERD---ASQCYIKMVCLRKPPQLVLGLHFLGPNAGE 414

Query: 436 VTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           VTQ   L +K G +Y Q++  VGIHPT AE    L ++K
Sbjct: 415 VTQGFALGIKCGASYAQVMRTVGIHPTCAEEVAKLRISK 453


>ref|XP_002423998.1| thioredoxin reductase, putative [Pediculus humanus corporis]
 gb|EEB11260.1| thioredoxin reductase, putative [Pediculus humanus corporis]
          Length = 802

 Score =  449 bits (1156), Expect = e-124
 Identities = 245/480 (51%), Positives = 319/480 (66%), Gaps = 13/480 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGSGGLA +KEAA  G+ V + D+VKP+ +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 317 YDYDLVVVGGGSGGLAAAKEAATLGRTVALCDFVKPTPMGTTWGLGGTCVNVGCIPKKLM 376

Query: 62  HQSSLIGETIHKDSKAFGWT--VGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+S+  E  H DS +FGW     +    W  M+++V +YIKS+NF Y+ EL  +KVKY 
Sbjct: 377 HQASIHAEN-HHDSSSFGWNFHTSDGHHTWETMVENVQNYIKSLNFGYRKELNKRKVKYL 435

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGGDLAISSDDIFWRKE 178
           N    F+  H L+L + K     V+ +D++IAVGGRP  P      +  I+SDD+F   +
Sbjct: 436 NAYAEFVAPHKLKLTNKKGEVSEVSAKDIIIAVGGRPAYPNVPGAKEFCITSDDLFSLSK 495

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL+VGASY+ALEC GF+KG+GYDV IMVRSILLRGFD+ +AD IGE ME +  I+F
Sbjct: 496 PPGKTLIVGASYIALECGGFLKGLGYDVTIMVRSILLRGFDRQIADLIGEHME-KIGIKF 554

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADG-EACEEAFDTVLNATGRDPDVAKLGLDK-AGVKL 296
           ++   P    K   G++ V   +  G E     FDTV+ A GR+    KLGL+    +K+
Sbjct: 555 VKEYEPIGFNKTNEGKIKVAAKSKKGDEIVVSGFDTVVLAIGREACTGKLGLENLPNLKI 614

Query: 297 NPKTGRIWV-ENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           NPK  +I V E E++S P+VYAIGDVID  PELTPVAI AG+ LA+R+        +Y +
Sbjct: 615 NPKNKKIIVDEFERSSVPHVYAIGDVIDGKPELTPVAIHAGKYLAQRICGVHNKTTNYKQ 674

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EYG  GLSEE +   FG++N+ +YH  F PLE +LS       +  Y K+I
Sbjct: 675 VPTTVFTPLEYGTVGLSEEEAFNIFGKENIVVYHNAFKPLEHALSRED----TLGYAKLI 730

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           C KS ++ VVGFH L PNAGE+TQ   +A+KL        +++GIHPT AEIFTTL   K
Sbjct: 731 CVKSLEELVVGFHVLSPNAGEITQGYAIALKLNAKKSDFDDLIGIHPTCAEIFTTLSRVK 790


>ref|XP_002773322.1| thioredoxin reductase 1, cytoplasmic, putative [Perkinsus marinus
           ATCC 50983]
 gb|EER05138.1| thioredoxin reductase 1, cytoplasmic, putative [Perkinsus marinus
           ATCC 50983]
          Length = 495

 Score =  448 bits (1152), Expect = e-123
 Identities = 248/481 (51%), Positives = 316/481 (65%), Gaps = 14/481 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL VIGGGSGGLA +K AA  G +V + D+VKPS  GT+WGLGGTCVNVGCIPKKL+
Sbjct: 9   YDWDLFVIGGGSGGLAAAKTAAALGARVALADFVKPSPQGTTWGLGGTCVNVGCIPKKLL 68

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           H S+   ET   DS   GW +   + +W  M+++V +YI S+N+ YK ELR   VKY N 
Sbjct: 69  HMSAHTAETAG-DSAGLGWEL-TASHNWEAMIQNVTTYISSLNWGYKSELRSTNVKYFNS 126

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG-GDLAISSDDIFWRKEAP 180
             +FID +TL+L   +     VT R ++IA GGRP      G G+  I+SDDIF RK  P
Sbjct: 127 FATFIDRNTLKLTDKRGKESIVTARYILIATGGRPNLGGYPGAGECCITSDDIFRRKAPP 186

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASY+ALECAGF+ G GYD  +MVRSILLRGFDQDMA +IG++ME+    +F+ 
Sbjct: 187 GKTLVVGASYIALECAGFIAGFGYDTTVMVRSILLRGFDQDMAQRIGKYMELHG-TKFVH 245

Query: 241 GCVPQSIMKLENGQLLV-----KWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
             +P    K E+G++ V       T +D ++    FDTVL A GR      L LD AGV 
Sbjct: 246 EMIPTKFEKTEDGKVRVYAKSSSDTMSDADSEFGVFDTVLMAVGRTGCAGWLSLDNAGVH 305

Query: 296 LNPKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYD 353
            NP  G+I V+  E T+  N+YAIGDV++   ELTPVAIQ+G++LA RL+   + LMDY 
Sbjct: 306 YNPDKGKIPVDKFEMTNIDNIYAIGDVVEGMLELTPVAIQSGKMLAARLFGGASRLMDYH 365

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKV 413
            V T VFTPIEYG  G SEE + E++G+D L +YH  F PL W+L+     A   CY+KV
Sbjct: 366 NVPTTVFTPIEYGSVGSSEENAKEEYGDD-LIVYHSFFKPLLWALNKDRGDA--DCYMKV 422

Query: 414 ICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVT 473
           +C+   DK VVG H LGP+AGE+ Q + +AMK G T   + + VGIHPT AE FTTL   
Sbjct: 423 LCENKGDKKVVGIHILGPDAGEMIQGLAVAMKAGCTKANLDDTVGIHPTCAETFTTLTQI 482

Query: 474 K 474
           K
Sbjct: 483 K 483


>gb|DAA20379.1| thioredoxin reductase 2, mitochondrial precursor [Bos taurus]
          Length = 460

 Score =  447 bits (1150), Expect = e-123
 Identities = 232/439 (52%), Positives = 308/439 (70%), Gaps = 12/439 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA+ GKKV VLDYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 28  YDLLVIGGGSGGLACAKEAAQLGKKVAVLDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQ 87

Query: 64  SSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLLG 123
           ++L+G  I +D+  +GW V +    WA +  +V +++KS+N+ ++++L+D+KVKY N+  
Sbjct: 88  AALLGGMI-RDAPHYGWGVAQAPHSWATLADAVQNHVKSLNWGHRIQLQDRKVKYFNVKA 146

Query: 124 SFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
           SF+D HT+     K G +T+ + + +VIA GGRP+ P   EG  +  I+SDD+FW KE+P
Sbjct: 147 SFVDTHTV-CGVSKGGEETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDLFWLKESP 205

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAG + G+G D  +M+RS+ LR FDQ MA  + E M        +R
Sbjct: 206 GKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPLRAFDQQMASLVTEHMAGHG-TRILR 264

Query: 241 GCVPQSIMKLENGQLLVKWTTADGEACEE-AFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GC P+ + KL   QL V W     +  +   FDTVL A GR P+ A L L+KAGV  NP 
Sbjct: 265 GCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKAGVHTNPV 324

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
           TG+I V+  E TS P++YAIGDV +  PELTP AI AGRLLA+RL    + LMDY  V T
Sbjct: 325 TGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLMDYSSVPT 384

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            VFTP+EYGC GLSEEA++ + GE+++E+YH  + PLE+++       AS CY+K++C +
Sbjct: 385 TVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRD---ASQCYIKMVCLR 441

Query: 418 SRDKYVVGFHYLGPNAGEV 436
              + V+G H+LGPNAGEV
Sbjct: 442 EPPQLVLGLHFLGPNAGEV 460


>gb|EAW79356.1| hCG40656, isoform CRA_b [Homo sapiens]
          Length = 459

 Score =  445 bits (1145), Expect = e-123
 Identities = 236/454 (51%), Positives = 315/454 (69%), Gaps = 17/454 (3%)

Query: 31  VLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQSSLIGETIHKDSKAFGWTVGEQT-FDW 89
           VLD+V PS  GTSWGLGGTCVNVGCIPKKLMHQ++L+G+ +  DS+ FGW   +Q   +W
Sbjct: 2   VLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALC-DSRKFGWEYNQQVRHNW 60

Query: 90  AQMLKSVNSYIKSINFKYKVELRDKKVKYENLLGSFIDAHTLELWHPKKGTKTV-TTRDV 148
             M K++ ++I S+N+ Y++ LR+K V Y N  G F++ H ++  + KKG +T  T    
Sbjct: 61  ETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATN-KKGQETYYTAAQF 119

Query: 149 VIAVGGRPKPLACEGG-DLAISSDDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVK 207
           VIA G RP+ L  +G  +  I+SDD+F     PGKTLVVGASYVALECAGF+ G G DV 
Sbjct: 120 VIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVT 179

Query: 208 IMVRSILLRGFDQDMADKIGEFMEVESKIEFIRGCVPQSIMKLENG-----QLLVKWTTA 262
           +MVRSILLRGFDQ+MA+K+G +ME +  ++F+R  +P  + +LE G     ++L K +T 
Sbjct: 180 VMVRSILLRGFDQEMAEKVGSYME-QHGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STE 237

Query: 263 DGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPKTGRIWVEN-EQTSTPNVYAIGDV 321
             E  E  ++TVL A GRD    K+GL+K GVK+N K+G+I V + EQT+ P VYA+GD+
Sbjct: 238 GTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDI 297

Query: 322 I-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFG 380
           + D PELTPVAIQ+G+LLA+RL+       DY  V T VFTP+EYGCCGLSEE +IE + 
Sbjct: 298 LEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYK 357

Query: 381 EDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAM 440
           ++NLEIYH  F PLEW+++       ++CY K+IC+K     V+GFH LGPNAGEVTQ  
Sbjct: 358 KENLEIYHTLFWPLEWTVAGREN---NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGF 414

Query: 441 GLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             AMK G T   + + +GIHPT  E+FTTLE+TK
Sbjct: 415 AAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITK 448


>gb|ACL81231.1| thioredoxin reductase 2 [Moneuplotes crassus]
          Length = 508

 Score =  442 bits (1138), Expect = e-122
 Identities = 233/478 (48%), Positives = 313/478 (65%), Gaps = 8/478 (1%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVG---TSWGLGGTCVNVGCIPK 58
           YDYDL VIGGGSGGLAC+K A + G KV V D+VKPS  G    +WG+GGTCVNVGCIPK
Sbjct: 21  YDYDLFVIGGGSGGLACAKAAQECGAKVAVADFVKPSPHGYGVVTWGVGGTCVNVGCIPK 80

Query: 59  KLMHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           KL+H S+ +GE  + D  + GW   +   DW +M+ ++N++I++INF  K +LR + +K+
Sbjct: 81  KLLHYSANLGEA-YVDRASSGWDHEKPKHDWGKMISNINNHIRAINFSIKTDLRKRGIKF 139

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
              L SF D HT++L + K  T+ VT   +VIA GGRP      G  +  I+SDDIFW K
Sbjct: 140 YEKLASFADPHTIQLLNKKGKTELVTANHIVIATGGRPLYPDIPGAKEYGITSDDIFWLK 199

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           + PGKTLV+GASY+ALECAGF+   G DV + VRS+ LRGFDQDMA+ + + ME    ++
Sbjct: 200 KNPGKTLVIGASYIALECAGFLHSFGNDVSVCVRSVFLRGFDQDMANMLAKDMEEHGGVK 259

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           FI+  +P  I K E    L+ + T+  E      DTVL A GR      L L+ AG+K+ 
Sbjct: 260 FIKNSIPTKIEKDEETGKLICYLTSREEEITIEVDTVLFAIGRYAVTKDLNLENAGLKVE 319

Query: 298 PKTGRIWVENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYDKVC 356
                I  E +QT+  N+YAIGDVI    ELTP AIQ G+LLARRLY  ETT MD+  + 
Sbjct: 320 SNGKFITDEFQQTNVENIYAIGDVIHGKLELTPTAIQTGKLLARRLYAGETTTMDFCDIP 379

Query: 357 TAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICD 416
           T +FTP+EYGC G SEE + EK+G D +++YH  F PLEW+ + +      +CYVKVI +
Sbjct: 380 TTIFTPLEYGCVGYSEEEAKEKYG-DAIKVYHTYFKPLEWNYAKSIY-KYRNCYVKVIIN 437

Query: 417 KSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
            + +  V+G+H L PNAGE+TQ + +A+K+G T  ++ N VGIHPT AE  T L++ K
Sbjct: 438 TTENDRVIGYHLLAPNAGEITQGIAIAIKIGLTKHKLDNCVGIHPTVAEEVTDLKIDK 495


>dbj|BAE28994.1| unnamed protein product [Mus musculus]
          Length = 431

 Score =  441 bits (1135), Expect = e-122
 Identities = 234/424 (55%), Positives = 298/424 (70%), Gaps = 13/424 (3%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YD+DL++IGGGSGGLA +KEAAK+ KKV VLD+V P+ +GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           MHQ++L+G+ + KDS+ +GW V +    DW +M +SV S+I S+N+ Y+V LR+K+V YE
Sbjct: 70  MHQAALLGQAL-KDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKEVVYE 128

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N  G FI  H +   + K   K  +    +IA G RP+ L   G  +  ISSDD+F    
Sbjct: 129 NAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPY 188

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G+G DV +MVRSILLRGFDQDMA+KIGE ME E  I+F
Sbjct: 189 CPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKF 247

Query: 239 IRGCVPQSIMKLENGQ----LLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGV 294
           IR  VP  I ++E G      +   +T   E  E  F+TVL A GRD     +GL+  GV
Sbjct: 248 IRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGV 307

Query: 295 KLNPKTGRIWV-ENEQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDY 352
           K+N KTG+I V + EQT+ P +YAIGD+++   ELTPVAIQAGRLLA+RLY       DY
Sbjct: 308 KINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDY 367

Query: 353 DKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVK 412
           D V T VFTP+EYGCCGLSEE ++EKFGE+N+E+YH  F PLEW++ S      + CY K
Sbjct: 368 DNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---NKCYAK 424

Query: 413 VICD 416
           +IC+
Sbjct: 425 IICN 428


>gb|ACL81230.1| thioredoxin reductase 1 [Moneuplotes crassus]
          Length = 498

 Score =  441 bits (1134), Expect = e-121
 Identities = 241/477 (50%), Positives = 313/477 (65%), Gaps = 8/477 (1%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL VIGGGSGGLAC+K A + G KV V D+VKP+  GT W +GGTCVNVGCIPKKL
Sbjct: 14  SYDYDLFVIGGGSGGLACAKVAQEAGAKVAVADFVKPTPKGTKWKVGGTCVNVGCIPKKL 73

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH S+L+G + H D    GW   + + DW +M+ +VN++I+ INF YK ++R + +K+  
Sbjct: 74  MHYSALLGNSYH-DQVESGWEHEKPSHDWGKMITNVNNHIRGINFGYKADMRKRGIKFHE 132

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
              SF+D HT++L   K  T+ +T+   VIA GGRP      G  + AI+SDDIFW K+ 
Sbjct: 133 KFASFVDPHTVQLVDKKGKTEMITSNYFVIATGGRPLYPDIPGAKEHAITSDDIFWMKDN 192

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTLVVGASYVALECAGF+   G +V + VRSI LRGFDQDMA KI + ME+ S I FI
Sbjct: 193 PGKTLVVGASYVALECAGFLHHFGNEVSVCVRSIFLRGFDQDMAQKIAKDMEL-SGINFI 251

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           R  VP  I K E    L  + T  GE      DTVL A GR    A L L  AG+ +  K
Sbjct: 252 RDSVPTKIEKDEETGKLTCFLTVGGEETTVEVDTVLFAIGRYAVTADLNLGNAGL-IAEK 310

Query: 300 TGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            G+   +  ++T+  N+YAIGDV+    ELTP AIQAGRLLA RL+   TT MD+  V T
Sbjct: 311 NGKFITDKYQKTNVDNIYAIGDVLHGKLELTPTAIQAGRLLADRLFAGGTTTMDFYDVPT 370

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
            +FTP+EYGC G SEE + E++G D +++YH  F PLEW+ + +      +CYVK+I + 
Sbjct: 371 TIFTPLEYGCVGYSEEDAREEYG-DFIKVYHTYFQPLEWNFAKSIY-KERNCYVKIIVNT 428

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           + +  V+GFH L PNAGE+TQ + +A+K+G T  Q+ N VGIHPT AE  T L + K
Sbjct: 429 ADNDRVIGFHILCPNAGEITQGIAIAIKVGVTKPQLDNCVGIHPTIAEEMTNLHIDK 485


>ref|XP_002428198.1| thioredoxin reductase, putative [Pediculus humanus corporis]
 gb|EEB15460.1| thioredoxin reductase, putative [Pediculus humanus corporis]
          Length = 490

 Score =  440 bits (1131), Expect = e-121
 Identities = 223/476 (46%), Positives = 320/476 (67%), Gaps = 11/476 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+K+A+  G  VC++DYV PS  G +WG+GGTCVNVGCIPKKLMHQ
Sbjct: 8   FDLIVIGGGSGGLACAKQASTLGASVCLIDYVTPSPKGNTWGMGGTCVNVGCIPKKLMHQ 67

Query: 64  SSLIGETIHKDSKAFGWTVGE---QTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           ++L+GE I +D+ A+GW + +      DW ++ +++ ++IKS+N+  +V L++ K++Y N
Sbjct: 68  AALLGEAI-QDAAAYGWVINDLDKVKIDWERLKQAIQNHIKSVNWVTRVILKENKIEYIN 126

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKEA 179
            +G FID +T+E+   K  +K +  ++++IAVGGRPK     G  +  ISSDDIF    A
Sbjct: 127 GIGKFIDKNTIEV-TTKTDSKNIYGKNILIAVGGRPKYPDIPGAVEYGISSDDIFNLPSA 185

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGK LVVGA Y+ALECAGF+    + V +MVRS+ LR FDQ MA  I + +  +  + F+
Sbjct: 186 PGKVLVVGAGYIALECAGFLNSFKFPVTVMVRSVTLRNFDQQMAHLIEKNLS-DRGVTFL 244

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           +  +P  I K      +    + + +   E FD VL A GR      L L   GVK++ +
Sbjct: 245 KETLPVKIEKNNKNLTVTYKNSKNDQIKNENFDNVLFAIGRKTSTEGLNLQAIGVKIDKE 304

Query: 300 TGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCTA 358
           +G+I  ENE+T+ PN+YA+GDV+   PELTPVAI+AG+LLA+RL+ N    M+Y+ + T 
Sbjct: 305 SGKIIAENERTNIPNIYAVGDVLHGKPELTPVAIEAGKLLAKRLFGNSNEYMNYENIATT 364

Query: 359 VFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKS 418
           +F P+EYGC GLSEE +IEKFGE N+E+YH  + P E+ +      +A+ CY+KV+  ++
Sbjct: 365 IFCPLEYGCVGLSEEKAIEKFGEANIEVYHTFYKPTEFFIPD---KSAAQCYLKVVTMRN 421

Query: 419 RDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             K V+G H++GP+AGE+ Q    AMK  FT DQ++  VGIHPT +E FT L VTK
Sbjct: 422 DPKLVLGMHFVGPSAGEIIQGYAAAMKCKFTMDQLIATVGIHPTISEEFTKLVVTK 477


>ref|XP_003093270.1| CRE-TRXR-1 protein [Caenorhabditis remanei]
 gb|EFO94530.1| CRE-TRXR-1 protein [Caenorhabditis remanei]
          Length = 666

 Score =  439 bits (1128), Expect = e-121
 Identities = 239/488 (48%), Positives = 328/488 (67%), Gaps = 21/488 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEAA+ GKKV  LD+VKPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 173 HTYDLIVIGGGSGGLAAAKEAARLGKKVACLDFVKPSPQGTTWGLGGTCVNVGCIPKKLM 232

Query: 62  HQSSLIGETIHKDSKAFGWTV-GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ+SL+G +IH D++ FGW + G+    W+ +  SV  +I S+N+ Y+V+LR+K V Y N
Sbjct: 233 HQASLLGHSIH-DAQKFGWKLEGKPEHQWSHLRDSVQDHIASLNWGYRVQLREKTVTYIN 291

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG-GDLAISSDDIFWRKEA 179
             G F     +   + KK  + +T    +IA G RPK     G  +  I+SDD+F    +
Sbjct: 292 SYGEFTGPFEISATNKKKKVEKITADRFLIATGLRPKYPDFPGVKEYTITSDDLFQLPYS 351

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTL VGASYV+LECAGF+ G+G+DV +MVRSILLRGFDQDMA++I + M +   ++F 
Sbjct: 352 PGKTLCVGASYVSLECAGFLHGLGFDVTVMVRSILLRGFDQDMAERIRKHM-IAYGLKFE 410

Query: 240 RGCVPQSIMKLEN------GQLLVKWTTADGEACE-----EAFDTVLNATGRDPDVAKLG 288
            G VP  I ++E       G+  V W   + E  E     E ++T+L A GR+     +G
Sbjct: 411 SG-VPTKIEQIEEKTDEKAGKYRVYWPKKNEETGEMQEFSEEYNTILYAIGREAVTDDVG 469

Query: 289 LDKAGVKLNPKTGRIWVENEQTST-PNVYAIGDVID-APELTPVAIQAGRLLARRLYNNE 346
           L+  GV+   K+ ++    EQ++T P VYAIGDV++  PELTPVAIQAGR+L RR++   
Sbjct: 470 LETIGVE-RAKSKKVVGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIFEGA 528

Query: 347 TTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAA 406
             L +YD++ T VFTP+EYGCCGL+EE +++K+G++N+ IYH  F PLE+++S   R   
Sbjct: 529 NELTEYDQIPTTVFTPLEYGCCGLAEEDAVKKYGKENIIIYHNVFNPLEYTISE--RMDK 586

Query: 407 SSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEI 466
             CY+K+IC ++ ++ VVGFH L PNAGE+TQ  G+A+KL         ++GIHPT AE 
Sbjct: 587 DHCYLKLICLRNEEEKVVGFHILTPNAGEITQGFGIALKLSAKKADFDRLIGIHPTVAES 646

Query: 467 FTTLEVTK 474
           FTTL + K
Sbjct: 647 FTTLTLEK 654


>ref|XP_002633065.1| C. briggsae CBR-TRXR-1 protein [Caenorhabditis briggsae]
 emb|CAP26568.1| CBR-TRXR-1 protein [Caenorhabditis briggsae AF16]
          Length = 667

 Score =  439 bits (1128), Expect = e-121
 Identities = 243/489 (49%), Positives = 326/489 (66%), Gaps = 22/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEAA+ GKKV  LD+VKPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 173 HTYDLIVIGGGSGGLAAAKEAARLGKKVACLDFVKPSPQGTTWGLGGTCVNVGCIPKKLM 232

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+G +IH D+K FGW +  G+    W  M  SV  +I S+N+ Y+V+LR+K V Y 
Sbjct: 233 HQASLLGHSIH-DAKKFGWKLPEGKIEHQWGHMRDSVQDHIASLNWGYRVQLREKTVTYI 291

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG-GDLAISSDDIFWRKE 178
           N  G F     +   + KK  + +T    +IA G RPK     G  +  I+SDD+F    
Sbjct: 292 NSYGEFTGPFEISATNKKKKVEKLTADRFLIATGLRPKYPDYPGVKEYTITSDDLFQLPY 351

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTL VGASYV+LECAGF+ G+G+DV +MVRSILLRGFDQDMA++I + M +   I+F
Sbjct: 352 SPGKTLCVGASYVSLECAGFLHGLGFDVTVMVRSILLRGFDQDMAERIRKHM-IAYGIKF 410

Query: 239 IRGCVPQSIMKLEN------GQLLVKWTTADGEACEEA-----FDTVLNATGRDPDVAKL 287
             G VP  I ++E       G+  V W   + E  EE      ++T+L A GR+    ++
Sbjct: 411 ESG-VPTRIEQIEEKTDEKAGRYRVFWPKKNEETGEETEVSEEYNTILYAIGREAVTDEV 469

Query: 288 GLDKAGVKLNPKTGRIWVENEQTST-PNVYAIGDVID-APELTPVAIQAGRLLARRLYNN 345
           GLD  GV+   K+ ++    EQ +T P VYAIGDV++  PELTPVAIQAGR+L RR++  
Sbjct: 470 GLDSIGVE-RAKSKKVVGRREQATTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIFEG 528

Query: 346 ETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPA 405
              L +Y+++ T VFTP+EYGCCGL+EE +I+K+G++N+ IYH  F PLE+++    R  
Sbjct: 529 VNELTEYEQIPTTVFTPLEYGCCGLAEEDAIKKYGKENIIIYHNVFNPLEYTIPE--RMD 586

Query: 406 ASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
              CY+K+IC ++ ++ VVGFH L PNAGEVTQ  G+A+KL         ++GIHPT AE
Sbjct: 587 KDHCYLKLICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAE 646

Query: 466 IFTTLEVTK 474
            FTTL + K
Sbjct: 647 SFTTLTLEK 655


>ref|XP_001898729.1| Thioredoxin reductase [Brugia malayi]
 gb|EDP31537.1| Thioredoxin reductase, putative [Brugia malayi]
          Length = 636

 Score =  438 bits (1127), Expect = e-121
 Identities = 239/487 (49%), Positives = 326/487 (66%), Gaps = 20/487 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           ++YDL ++GGGSGGLA +KEA + GKKV  LD+VKPS +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 145 HEYDLAIVGGGSGGLAAAKEAVRLGKKVVCLDFVKPSAMGTTWGLGGTCVNVGCIPKKLM 204

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ++L+GE I +D+K FGW +  G    +W Q+  +V ++I S+N+ Y+V+L++K V Y 
Sbjct: 205 HQAALLGEYI-EDAKKFGWEIPEGAIKLNWHQLKNAVQNHIASLNWGYRVQLKEKSVTYM 263

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N   +F  +H L + + K   + VT    +IAVG RP+     G  +  ISSDD+F    
Sbjct: 264 NSYATFTGSHELSVKNKKGKVEKVTADRFLIAVGLRPRFPDVPGALECCISSDDLFSLPY 323

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL VGASYV+LECAGF+KG+G DV +MVRS+LLRGFDQDMA++I + M  E  ++F
Sbjct: 324 NPGKTLCVGASYVSLECAGFLKGIGNDVTVMVRSVLLRGFDQDMAERIKKHM-TERGVKF 382

Query: 239 IRGCVPQSIMKL------ENGQLLVKWTTADGEACEEA---FDTVLNATGRDPDVAKLGL 289
           ++ CVP    +L      E G + V     D +  +E    F+TVL A GRD     LGL
Sbjct: 383 VQ-CVPIKYERLKKPTDSEPGMIRVHTMQEDEDGTKEVTEDFNTVLMAIGRDAMTDDLGL 441

Query: 290 DKAGVKLNPKTGRIWVENEQT-STPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNET 347
           D  GV    K+G+I    EQ+ S P VYAIGDV+  +PELTPVAIQAG++L RRL+   +
Sbjct: 442 DVVGVN-RAKSGKIIGRREQSVSCPYVYAIGDVLYGSPELTPVAIQAGKVLMRRLFTGSS 500

Query: 348 TLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAAS 407
            L +YDK+ T VFTP+EYG CGLSE ++I+K+G++N+ +YH  F PLE++++   R   +
Sbjct: 501 ELTEYDKIPTTVFTPLEYGSCGLSEYSAIQKYGKENINVYHNVFIPLEYAVTE--RKEKT 558

Query: 408 SCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIF 467
            CY K+IC K+    ++GFH L PNAGE+TQ   +A+K          ++GIHPT AE F
Sbjct: 559 HCYCKLICLKNEQDLILGFHILTPNAGEITQGFAIALKFDAKKADFDRLIGIHPTVAENF 618

Query: 468 TTLEVTK 474
           TTL + K
Sbjct: 619 TTLTLVK 625


>ref|XP_666572.1| thioredoxin reductase [Cryptosporidium hominis TU502]
 gb|EAL36345.1| thioredoxin reductase [Cryptosporidium hominis]
          Length = 521

 Score =  437 bits (1124), Expect = e-120
 Identities = 232/488 (47%), Positives = 330/488 (67%), Gaps = 23/488 (4%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T+ YDLVVIGGGSGG+A +KEAAKYGKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 25  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 84

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH S+LI  +IH D++ FG      +F+W ++++++ ++I+ +NF Y+  LR   V+Y N
Sbjct: 85  MHYSALISSSIHHDAQMFGHKT-SSSFEWGKLVETLRNHIRMLNFSYRTGLRVGNVEYIN 143

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
            L   ID H++E +      KT+T+R +++A GGRP  P    G    +I+SDDIF+  +
Sbjct: 144 ALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDIFFLSK 202

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLV+GASY+ LE AGF+  +G+D  + +RSI LRGFD+  ++KI E+M+  +  +F
Sbjct: 203 SPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMKA-TGTKF 261

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           + G VP +I K+      +K + +DG    E F+TVL ATGR+PDV  L L+  GV+++ 
Sbjct: 262 LVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAVGVEVS- 315

Query: 299 KTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            +G+I    + TS P+++A+GD+++  PELTPVA++AG LLARRL+      +DYD V T
Sbjct: 316 DSGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFIDYDFVPT 375

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRP-----------AA 406
            VFTPIEYG  GLS EA+I K+GED++E Y   F+ LE + +   +P             
Sbjct: 376 TVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENEMDFALP 435

Query: 407 SSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEI 466
            +C  K++  KS+ + VVGFH++GPNAGE+TQ   LA+KLG T     +++GIHPT AE+
Sbjct: 436 LNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIHPTDAEV 495

Query: 467 FTTLEVTK 474
           F  LEVTK
Sbjct: 496 FGILEVTK 503


>dbj|BAJ77264.1| cgd2_4320 [Cryptosporidium parvum]
 dbj|BAJ78027.1| cgd2_4320 [Cryptosporidium parvum]
          Length = 508

 Score =  437 bits (1123), Expect = e-120
 Identities = 232/488 (47%), Positives = 330/488 (67%), Gaps = 23/488 (4%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T+ YDLVVIGGGSGG+A +KEAAKYGKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 12  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 71

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH S+LI  +IH D++ FG      +F+W ++++++ ++I+ +NF Y+  LR   V+Y N
Sbjct: 72  MHYSALIASSIHHDAQMFGHKT-SSSFEWGKLVETLRNHIRMLNFSYRTGLRVGNVEYIN 130

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
            L   ID H++E +      KT+T+R +++A GGRP  P    G    +I+SDDIF+  +
Sbjct: 131 ALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDIFFLSK 189

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLV+GASY+ LE AGF+  +G+D  + +RSI LRGFD+  ++KI E+M+  +  +F
Sbjct: 190 SPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMKA-TGTKF 248

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           + G VP +I K+      +K + +DG    E F+TVL ATGR+PDV  L L+  GV+++ 
Sbjct: 249 LVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAIGVEVS- 302

Query: 299 KTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            +G+I    + TS P+++A+GD+++  PELTPVA++AG LLARRL+      +DYD V T
Sbjct: 303 DSGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFIDYDFVPT 362

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRP-----------AA 406
            VFTPIEYG  GLS EA+I K+GED++E Y   F+ LE + +   +P             
Sbjct: 363 TVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENEMDFALP 422

Query: 407 SSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEI 466
            +C  K++  KS+ + VVGFH++GPNAGE+TQ   LA+KLG T     +++GIHPT AE+
Sbjct: 423 LNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIHPTDAEV 482

Query: 467 FTTLEVTK 474
           F  LEVTK
Sbjct: 483 FGILEVTK 490


>gb|AAN05789.1| putative thioredoxin reductase [Cryptosporidium parvum]
          Length = 521

 Score =  437 bits (1123), Expect = e-120
 Identities = 232/488 (47%), Positives = 330/488 (67%), Gaps = 23/488 (4%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T+ YDLVVIGGGSGG+A +KEAAKYGKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 25  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 84

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH S+LI  +IH D++ FG      +F+W ++++++ ++I+ +NF Y+  LR   V+Y N
Sbjct: 85  MHYSALIASSIHHDAQMFGHKT-SSSFEWGKLVETLRNHIRMLNFSYRTGLRVGNVEYIN 143

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
            L   ID H++E +      KT+T+R +++A GGRP  P    G    +I+SDDIF+  +
Sbjct: 144 ALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDIFFLSK 202

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLV+GASY+ LE AGF+  +G+D  + +RSI LRGFD+  ++KI E+M+  +  +F
Sbjct: 203 SPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMKA-TGTKF 261

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           + G VP +I K+      +K + +DG    E F+TVL ATGR+PDV  L L+  GV+++ 
Sbjct: 262 LVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAIGVEVS- 315

Query: 299 KTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            +G+I    + TS P+++A+GD+++  PELTPVA++AG LLARRL+      +DYD V T
Sbjct: 316 DSGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFIDYDFVPT 375

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRP-----------AA 406
            VFTPIEYG  GLS EA+I K+GED++E Y   F+ LE + +   +P             
Sbjct: 376 TVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENEMDFALP 435

Query: 407 SSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEI 466
            +C  K++  KS+ + VVGFH++GPNAGE+TQ   LA+KLG T     +++GIHPT AE+
Sbjct: 436 LNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIHPTDAEV 495

Query: 467 FTTLEVTK 474
           F  LEVTK
Sbjct: 496 FGILEVTK 503


>ref|XP_626611.1| thioredoxin reductase 1 [Cryptosporidium parvum Iowa II]
 gb|EAK88893.1| thioredoxin reductase 1 [Cryptosporidium parvum Iowa II]
          Length = 526

 Score =  437 bits (1123), Expect = e-120
 Identities = 232/488 (47%), Positives = 330/488 (67%), Gaps = 23/488 (4%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T+ YDLVVIGGGSGG+A +KEAAKYGKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 30  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 89

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH S+LI  +IH D++ FG      +F+W ++++++ ++I+ +NF Y+  LR   V+Y N
Sbjct: 90  MHYSALIASSIHHDAQMFGHKT-SSSFEWGKLVETLRNHIRMLNFSYRTGLRVGNVEYIN 148

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
            L   ID H++E +      KT+T+R +++A GGRP  P    G    +I+SDDIF+  +
Sbjct: 149 ALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDIFFLSK 207

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLV+GASY+ LE AGF+  +G+D  + +RSI LRGFD+  ++KI E+M+  +  +F
Sbjct: 208 SPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMKA-TGTKF 266

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           + G VP +I K+      +K + +DG    E F+TVL ATGR+PDV  L L+  GV+++ 
Sbjct: 267 LVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAIGVEVS- 320

Query: 299 KTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            +G+I    + TS P+++A+GD+++  PELTPVA++AG LLARRL+      +DYD V T
Sbjct: 321 DSGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFIDYDFVPT 380

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRP-----------AA 406
            VFTPIEYG  GLS EA+I K+GED++E Y   F+ LE + +   +P             
Sbjct: 381 TVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENEMDFALP 440

Query: 407 SSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEI 466
            +C  K++  KS+ + VVGFH++GPNAGE+TQ   LA+KLG T     +++GIHPT AE+
Sbjct: 441 LNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIHPTDAEV 500

Query: 467 FTTLEVTK 474
           F  LEVTK
Sbjct: 501 FGILEVTK 508


>ref|XP_969619.1| PREDICTED: similar to thioredoxin reductase [Tribolium castaneum]
 gb|EFA02207.1| hypothetical protein TcasGA2_TC007865 [Tribolium castaneum]
          Length = 524

 Score =  434 bits (1117), Expect = e-119
 Identities = 223/476 (46%), Positives = 313/476 (65%), Gaps = 10/476 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL+VIGGGSGGLA +KEAA+ G KV V D++ PS     WGL GTC+N+  IPKKLMH
Sbjct: 42  EFDLIVIGGGSGGLAAAKEAAELGAKVAVFDFIVPSARSLKWGLEGTCINIESIPKKLMH 101

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT---FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           + +++GE + +D++++G+   +      +W  + ++V ++IKSIN+  K+ELRDK+V+Y 
Sbjct: 102 RVAILGEAV-QDARSYGFQFPKMESLKHNWKGLRETVQNHIKSINWVTKIELRDKRVEYI 160

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGGDLAISSDDIFWRKEA 179
           N +G F D +T+E    K   KT   +  +I+VGGRPK     G +L ISSD++F  + A
Sbjct: 161 NSMGVFHDPYTIEA-KIKNEWKTFKAKYFLISVGGRPKYPDIPGAELGISSDEVFGLENA 219

Query: 180 PGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFI 239
           PGKTL++GA YV +ECAGF+KG+GYD+ +MVRS++LR FDQ MA  + E M V   + F+
Sbjct: 220 PGKTLIIGAGYVGVECAGFLKGLGYDITVMVRSVVLRAFDQQMAKLVTESM-VAKGVRFL 278

Query: 240 RGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
             CVP SI +     LLVKW     E   + F TVL A GR+  +  L LDKAGV +   
Sbjct: 279 HKCVPTSIERSNGKMLLVKWIDETREEGCDEFQTVLFAIGREACIRALRLDKAGVSVVAD 338

Query: 300 TGRIWVENEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYDKVCTA 358
             +I   NEQT+ P++YA+GDV+   P+LT VAI AG+LLARRL+   T LMDYD + T 
Sbjct: 339 GDKIETINEQTNVPHIYAVGDVLYKKPDLTQVAIHAGKLLARRLFAKSTVLMDYDNIATT 398

Query: 359 VFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDKS 418
           +FTP+EYG  GL EE +IE++GEDN+EIYH  + P E+ +   T    + CY+KV+  + 
Sbjct: 399 IFTPLEYGSVGLCEETAIERYGEDNIEIYHAYYKPTEFFIPQKTN---AHCYLKVVAKRG 455

Query: 419 RDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             + V+G H++GP AGEV Q    A+K   T D + N VGIHP  AE F+ + +TK
Sbjct: 456 NQQKVLGMHFVGPQAGEVIQGFSAAIKCNLTVDNLRNTVGIHPAIAEEFSRINLTK 511


>gb|ACV31866.1| thioredoxin reductase [Cryptosporidium parvum]
          Length = 521

 Score =  434 bits (1115), Expect = e-119
 Identities = 231/488 (47%), Positives = 329/488 (67%), Gaps = 23/488 (4%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T+ YDLVVIGGGSGG+A +KEAAKYGKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 25  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 84

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH S+LI  +IH D++  G      +F+W ++++++ ++I+ +NF Y+  LR   V+Y N
Sbjct: 85  MHYSALIASSIHHDAQMSGHKT-SSSFEWGKLVETLRNHIRMLNFSYRTGLRVGNVEYIN 143

Query: 121 LLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
            L   ID H++E +      KT+T+R +++A GGRP  P    G    +I+SDDIF+  +
Sbjct: 144 ALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDIFFLSK 202

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLV+GASY+ LE AGF+  +G+D  + +RSI LRGFD+  ++KI E+M+  +  +F
Sbjct: 203 SPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMKA-TGTKF 261

Query: 239 IRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNP 298
           + G VP +I K+      +K + +DG    E F+TVL ATGR+PDV  L L+  GV+++ 
Sbjct: 262 LVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAIGVEVS- 315

Query: 299 KTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
            +G+I    + TS P+++A+GD+++  PELTPVA++AG LLARRL+      +DYD V T
Sbjct: 316 DSGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFIDYDFVPT 375

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRP-----------AA 406
            VFTPIEYG  GLS EA+I K+GED++E Y   F+ LE + +   +P             
Sbjct: 376 TVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENEMDFALP 435

Query: 407 SSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEI 466
            +C  K++  KS+ + VVGFH++GPNAGE+TQ   LA+KLG T     +++GIHPT AE+
Sbjct: 436 LNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIHPTDAEV 495

Query: 467 FTTLEVTK 474
           F  LEVTK
Sbjct: 496 FGILEVTK 503


>gb|AAD46625.1| thioredoxin reductase homolog [Caenorhabditis elegans]
          Length = 525

 Score =  433 bits (1114), Expect = e-119
 Identities = 239/489 (48%), Positives = 325/489 (66%), Gaps = 22/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEA++ GKKV  LD+VKPS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 29  HTYDLIVIGGGSGGLAAAKEASRLGKKVACLDFVKPSPQGTSWGLGGTCVNVGCIPKKLM 88

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+G +IH D+K +GW +  G+    W  +  SV  +I S+N+ Y+V+LR+K V Y 
Sbjct: 89  HQASLLGHSIH-DAKKYGWKLPEGKVEHQWNHLRDSVQDHIASLNWGYRVQLREKTVTYI 147

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG-GDLAISSDDIFWRKE 178
           N  G F     +   + KK  + +T    +I+ G RPK     G  +  I+SDD+F    
Sbjct: 148 NSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYPEIPGVKEYTITSDDLFQLPY 207

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTL VGASYV+LECAGF+ G G+DV +MVRSILLRGFDQDMA++I + M +   ++F
Sbjct: 208 SPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHM-IAYGMKF 266

Query: 239 IRGCVPQSIMKLEN------GQLLVKW-----TTADGEACEEAFDTVLNATGRDPDVAKL 287
             G VP  I +++       G+  V W      T + +   E ++T+L A GR+     +
Sbjct: 267 EAG-VPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGREAVTDDV 325

Query: 288 GLDKAGVKLNPKTGRIWVENEQTST-PNVYAIGDVID-APELTPVAIQAGRLLARRLYNN 345
           GL   GV+   K+ ++    EQ++T P VYAIGDV++  PELTPVAIQAGR+L RR+++ 
Sbjct: 326 GLTTIGVE-RAKSKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIFDG 384

Query: 346 ETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPA 405
              L +YD++ T VFTP+EYGCCGLSEE ++ K+G+DN+ IYH  F PLE+++S   R  
Sbjct: 385 ANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTISE--RMD 442

Query: 406 ASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
              CY+K+IC ++ ++ VVGFH L PNAGEVTQ  G+A+KL         ++GIHPT AE
Sbjct: 443 KDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAE 502

Query: 466 IFTTLEVTK 474
            FTTL + K
Sbjct: 503 NFTTLTLEK 511


>ref|NP_501085.2| ThioRedoXin Reductase family member (trxr-1) [Caenorhabditis
           elegans]
 sp|Q17745|TRXR1_CAEEL RecName: Full=Thioredoxin reductase 1; Short=TR-Se; Short=TRR
 gb|AAD41826.1|AF148217_1 thioredoxin reductase [Caenorhabditis elegans]
 gb|AAB03136.3| Thioredoxin reductase protein 1, confirmed by transcript evidence
           [Caenorhabditis elegans]
          Length = 667

 Score =  433 bits (1114), Expect = e-119
 Identities = 239/489 (48%), Positives = 325/489 (66%), Gaps = 22/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEA++ GKKV  LD+VKPS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 171 HTYDLIVIGGGSGGLAAAKEASRLGKKVACLDFVKPSPQGTSWGLGGTCVNVGCIPKKLM 230

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+G +IH D+K +GW +  G+    W  +  SV  +I S+N+ Y+V+LR+K V Y 
Sbjct: 231 HQASLLGHSIH-DAKKYGWKLPEGKVEHQWNHLRDSVQDHIASLNWGYRVQLREKTVTYI 289

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEG-GDLAISSDDIFWRKE 178
           N  G F     +   + KK  + +T    +I+ G RPK     G  +  I+SDD+F    
Sbjct: 290 NSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYPEIPGVKEYTITSDDLFQLPY 349

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTL VGASYV+LECAGF+ G G+DV +MVRSILLRGFDQDMA++I + M +   ++F
Sbjct: 350 SPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHM-IAYGMKF 408

Query: 239 IRGCVPQSIMKLEN------GQLLVKW-----TTADGEACEEAFDTVLNATGRDPDVAKL 287
             G VP  I +++       G+  V W      T + +   E ++T+L A GR+     +
Sbjct: 409 EAG-VPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGREAVTDDV 467

Query: 288 GLDKAGVKLNPKTGRIWVENEQTST-PNVYAIGDVID-APELTPVAIQAGRLLARRLYNN 345
           GL   GV+   K+ ++    EQ++T P VYAIGDV++  PELTPVAIQAGR+L RR+++ 
Sbjct: 468 GLTTIGVE-RAKSKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRIFDG 526

Query: 346 ETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPA 405
              L +YD++ T VFTP+EYGCCGLSEE ++ K+G+DN+ IYH  F PLE+++S   R  
Sbjct: 527 ANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTISE--RMD 584

Query: 406 ASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
              CY+K+IC ++ ++ VVGFH L PNAGEVTQ  G+A+KL         ++GIHPT AE
Sbjct: 585 KDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIHPTVAE 644

Query: 466 IFTTLEVTK 474
            FTTL + K
Sbjct: 645 NFTTLTLEK 653


>gb|ADL62852.1| thioredoxin reductase 1 [Haemonchus contortus]
          Length = 625

 Score =  432 bits (1110), Expect = e-119
 Identities = 240/489 (49%), Positives = 324/489 (66%), Gaps = 22/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           ++YDL+V+GGGSGGLA +K AA +GKKV VLD+VKPS  G++WGLGGTCVNVGCIPKKLM
Sbjct: 129 HNYDLIVVGGGSGGLAAAKMAALHGKKVAVLDFVKPSPQGSTWGLGGTCVNVGCIPKKLM 188

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ++++G +I KD+K FGW +  GE   +W  +  +V  +I S+N+ Y+V+LR+K+V Y 
Sbjct: 189 HQAAILGHSI-KDAKMFGWKIPEGEINHNWENLRNAVQDHISSLNWGYRVQLREKQVTYI 247

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK--PLACEGGDLAISSDDIFWRK 177
           N  G F     +   + K   + +T    +IA G RP+  P      +  ++SDD+F   
Sbjct: 248 NSYGRFTGPFEISATNKKGEVEKLTADRFLIATGLRPRYPPDVPGVREYCVTSDDLFSLP 307

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTL VGASYV+LECAGF++G+GYDV +MVRSILLRGFDQDMA++I   M+ E  ++
Sbjct: 308 YPPGKTLCVGASYVSLECAGFLQGLGYDVTVMVRSILLRGFDQDMAERIRAHMK-ECGVK 366

Query: 238 FIRGCVPQSIMKLE------NGQLLV----KWTTADGEACEEAFDTVLNATGRDPDVAKL 287
           F    VP  I ++E       G+L V    K +  + E   E F+TV+ A GRD     +
Sbjct: 367 F-ENAVPTRIEEIEPKTKKQAGRLRVFFARKISDTETEEHSEEFNTVVIAIGRDAMTKDI 425

Query: 288 GLDKAGVKLNPKTGRIWVENEQTST-PNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNN 345
           GLD  GV+     G++    EQ+ T P VYAIGDV  + PELTPVAIQAG++L  RLY  
Sbjct: 426 GLDVVGVE-TASNGKVKGRREQSLTCPYVYAIGDVPANTPELTPVAIQAGKVLMNRLYYG 484

Query: 346 ETTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPA 405
              L +YD+V T VFTP+EYGCCGL+EE + +++GEDN+ +YH  F PLE+++  A R  
Sbjct: 485 SDLLTEYDEVPTTVFTPLEYGCCGLTEENAKQRYGEDNVIVYHAVFIPLEYTV--AERMD 542

Query: 406 ASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAE 465
              CY K+IC  S ++ V+GFH L PNAGE+TQ  G+A+KLG T      ++GIHPT AE
Sbjct: 543 KDHCYCKLICLASDNERVIGFHILAPNAGEITQGFGIALKLGGTKADFDRLIGIHPTVAE 602

Query: 466 IFTTLEVTK 474
            FTTL + K
Sbjct: 603 SFTTLFLVK 611


>ref|NP_001166984.1| thioredoxin reductase 3 isoform 2 [Homo sapiens]
          Length = 607

 Score =  432 bits (1110), Expect = e-119
 Identities = 239/483 (49%), Positives = 318/483 (65%), Gaps = 53/483 (10%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PS  GTSWGLGGTCVNVGCIPKKLM
Sbjct: 155 YDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLM 214

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G+ +  DS+ FGW   +Q   +W  M K++ ++I S+N+ Y++ LR+K V Y N
Sbjct: 215 HQAALLGQAL-CDSRKFGWEYNQQVRHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVN 273

Query: 121 LLGSFIDAHTLELWHPKKGTKT-VTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
             G F++ H ++  + KKG +T  T    VIA G RP+ L  +G  +  I+SDD+F    
Sbjct: 274 SYGEFVEHHKIKATN-KKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLFSLPY 332

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTLVVGASYVALECAGF+ G G DV +MVRSILLRGFDQ+MA+K+G +ME +  ++F
Sbjct: 333 CPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKF 391

Query: 239 IRGCVPQSIMKLENG-----QLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           +R  +P  + +LE G     ++L K +T   E  E  ++TVL A GRD    K+GL+K G
Sbjct: 392 LRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIG 450

Query: 294 VKLNPKTGRIWVEN-EQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK+N K+G+I V + EQT+ P VYA+GD++ D PELTPVAIQ+G+LLA+RL+        
Sbjct: 451 VKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFG------- 503

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
                                 AS+EK       IYH  F PLEW+++       ++CY 
Sbjct: 504 ----------------------ASLEK-------IYHTLFWPLEWTVAGREN---NTCYA 531

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K+IC+K     V+GFH LGPNAGEVTQ    AMK G T   + + +GIHPT  E+FTTLE
Sbjct: 532 KIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLE 591

Query: 472 VTK 474
           +TK
Sbjct: 592 ITK 594


>ref|XP_001614770.1| thioredoxin reductase 2 [Plasmodium vivax SaI-1]
 gb|EDL45043.1| thioredoxin reductase 2, putative [Plasmodium vivax]
          Length = 546

 Score =  432 bits (1110), Expect = e-119
 Identities = 232/490 (47%), Positives = 312/490 (63%), Gaps = 22/490 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYD VVIGGG GG+A +KEAA +G KV + DYVKPS  GT WG+GGTCVNVGC+PKKLM
Sbjct: 44  YDYDYVVIGGGPGGMASAKEAAAHGAKVLLFDYVKPSSKGTKWGIGGTCVNVGCVPKKLM 103

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           H +  +G     DS  +GWT  + + +W +++ +V S+I+S+NF Y   LR  +VKY N 
Sbjct: 104 HYAGNMGSLFKLDSTQYGWTCKDLSHNWGKLVSTVQSHIRSLNFSYLTGLRSSQVKYING 163

Query: 122 LGSFIDAHTLE--LWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           L S  D HT+   L       +T+T + ++IA G RP  P   EG  +L+I+SDDIF  K
Sbjct: 164 LASLKDEHTVAYYLKGDMSQEETITAKYILIATGCRPHIPEDVEGARELSITSDDIFSMK 223

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           + PGKTL+VGASYVALECAGF+  +G+DV + VRSI+LRGFD   A K+  +ME E  + 
Sbjct: 224 KVPGKTLIVGASYVALECAGFLNSLGFDVTVAVRSIVLRGFDSQCALKVKNYME-EQGVL 282

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           F  G +P+ + K E  ++ V +T    +   E +DTVL ATGR  D+A L L++  + ++
Sbjct: 283 FKEGVLPKKLSKGEEDKVAVLFT----DGTTELYDTVLYATGRKGDIAMLHLERLNIHVD 338

Query: 298 PKTGRIWV-ENEQTSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
               +I   E   T+ PN++A+GDV +D PEL PVAI+AG +LARRL+     +MDY  +
Sbjct: 339 KSANKIITNEGSCTNVPNIFAVGDVAVDVPELAPVAIKAGEILARRLFKQSQEIMDYTFI 398

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR-----------P 404
            TA++TPIEYG CG SEE + E FG  N+E++ Q F  LE S     +            
Sbjct: 399 PTAIYTPIEYGACGYSEEKAYEAFGTSNVEVFLQEFNNLEISAVHREKHVRAQKDQYDTD 458

Query: 405 AASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTA 464
            +S+C  K++C KS D  VVGFHY+GPNAGEVTQ M LA++L        + VGIHPT A
Sbjct: 459 VSSTCLSKLVCLKSEDNRVVGFHYVGPNAGEVTQGMALALRLKARKSDFDSCVGIHPTDA 518

Query: 465 EIFTTLEVTK 474
           E F  L VT+
Sbjct: 519 ESFMNLSVTR 528


>ref|XP_002085912.1| GD15034 [Drosophila simulans]
 gb|EDX11497.1| GD15034 [Drosophila simulans]
          Length = 516

 Score =  430 bits (1106), Expect = e-118
 Identities = 232/483 (48%), Positives = 324/483 (67%), Gaps = 20/483 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDLVV+GGG GG+   +  A  G +V   DYVKP+ VGT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YNYDLVVLGGGLGGIGVRQGGAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTF--DWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ+SL+GE +H ++ A+GW V ++    DW ++++SV ++IKS+ +  + +L DKKV+Y 
Sbjct: 91  HQASLLGEAVH-EAVAYGWNVDDKNIRPDWGKLVRSVQNHIKSVKWVTRQDLGDKKVEYV 149

Query: 120 NLLGSFIDAHTLE-LWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRK 177
           N +GSF D+HT+E +  P    + VT+  VV+AVGGRP+     G  +L I+SDDIF  +
Sbjct: 150 NSMGSFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYE 209

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PG+TLV GA YV LECA F+KG+GY+  +MVRSI+LRGFD+ M++ +   M  E  I 
Sbjct: 210 REPGRTLVKGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TERGIP 268

Query: 238 FIRGCVPQSIMKLENGQLLVKW----TTADGEACEEAFDTVLNATGRDPDVAKLGLDKAG 293
           F+   +P+++ +  +G+LLV++    T  DG    + FDTVL A GR   +  L L+ AG
Sbjct: 269 FLGTTIPKAVERQADGRLLVRYRNTSTQMDG---SDVFDTVLWAIGRKGLIEDLNLEAAG 325

Query: 294 VKLNPKTGRIWVE-NEQTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMD 351
           VK +    +I V+  E TS P+++A+GD+I   PELTPVAI +GRLLARRL+   T LMD
Sbjct: 326 VKTH--DDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMD 383

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EY C G+SEE +IE  G DN+E++H  + P E+ +    + +   CY+
Sbjct: 384 YADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFI---PQKSVRHCYL 440

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           K + + S D+ ++G HY+GP AGEV Q    A+K G T   ++N VGIHPTTAE FT L 
Sbjct: 441 KAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTVLNTVGIHPTTAEEFTRLS 500

Query: 472 VTK 474
           +TK
Sbjct: 501 ITK 503


>ref|XP_002258509.1| thioredoxin reductase 2 [Plasmodium knowlesi strain H]
 emb|CAQ39281.1| thioredoxin reductase 2, putative [Plasmodium knowlesi strain H]
          Length = 623

 Score =  429 bits (1103), Expect = e-118
 Identities = 231/491 (47%), Positives = 312/491 (63%), Gaps = 24/491 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYD VVIGGG GG+A +KEAA +G KV + DYVKPS  GT WG+GGTCVNVGC+PKKLM
Sbjct: 121 YDYDYVVIGGGPGGMASAKEAASHGAKVLLFDYVKPSNKGTKWGIGGTCVNVGCVPKKLM 180

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           H +  +G     DS  +GW+      +W +++ +V S+I+S+NF Y   LR  KVKY N 
Sbjct: 181 HYAGNMGSLFKMDSNPYGWSYNNLIHNWGKLVTTVQSHIRSLNFSYMTGLRSSKVKYMNG 240

Query: 122 LGSFIDAHTLELWHPKKGTK--TVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           L S  D HT+  +     +K   VT + ++IA G RP  P   EG  +L+I+SDDIF  K
Sbjct: 241 LASLKDEHTVSYYLKGDMSKEELVTAKYILIATGCRPSIPDDVEGAKELSITSDDIFSMK 300

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           + PGKTL+VGASYVALECAGF+  +GYDV + VRSI+LRGFD   A K+  +ME E  + 
Sbjct: 301 KDPGKTLIVGASYVALECAGFLNSLGYDVTVAVRSIVLRGFDSQCALKVKIYME-EQGVL 359

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           F  G +P+ + K+E  ++ V +     +   E FDTVL ATGR  D+  L LD+  +++N
Sbjct: 360 FKHGVLPKKLSKMEGEKISVLF----NDGTTELFDTVLYATGRKGDIDMLNLDQVKIQVN 415

Query: 298 PKTGRIWVENEQ--TSTPNVYAIGDV-IDAPELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             T +I + NE   T+  N++A+GDV +D PEL PVAI+AG +LARRL+N    +MDY  
Sbjct: 416 KNTNKI-ITNEVSCTNISNIFAVGDVAVDVPELAPVAIKAGEILARRLFNQSEEIMDYTF 474

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR----------- 403
           + T+++TPIEYG CG SEE + E FG  N+E++ Q F  LE S     +           
Sbjct: 475 IPTSIYTPIEYGTCGYSEEKAYEIFGTSNVEVFLQEFNNLEISAVHREKHVRAQKDQYDT 534

Query: 404 PAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTT 463
             +S+C  K++C K+ D  VVGFHY+GPNAGE+TQ M LA++L          +GIHPT 
Sbjct: 535 DVSSTCLSKLVCLKNEDNRVVGFHYVGPNAGEITQGMALALRLKAKKSDFDKCIGIHPTD 594

Query: 464 AEIFTTLEVTK 474
           AE F  L +T+
Sbjct: 595 AESFMNLTITR 605


>ref|XP_001427531.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK60133.1| unnamed protein product [Paramecium tetraurelia]
          Length = 486

 Score =  429 bits (1103), Expect = e-118
 Identities = 236/479 (49%), Positives = 313/479 (65%), Gaps = 11/479 (2%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           T ++D  VIGGGSGGLA +K+AA  G KV + D+VKPS +GT WGLGGTCVNVGCIPKKL
Sbjct: 4   TQEFDFFVIGGGSGGLAAAKQAASQGAKVGLADFVKPSPLGTKWGLGGTCVNVGCIPKKL 63

Query: 61  MHQSSLIGETIHKDSKAFGWTVGE--QTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKY 118
           MH ++L GE + KD    GW   +     DW +M ++V S+IK +NF+YK +L +K+VKY
Sbjct: 64  MHFAALAGE-LRKDQVEAGWINADIKGKHDWNRMTENVRSHIKKLNFQYKNQLNNKEVKY 122

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK--PLACEGGDLAISSDDIFWR 176
            N L     ++ ++L     G + V ++ ++IAVGGRP       E     I+SDD+FW 
Sbjct: 123 YNKLAELEKSNIVKLIDKDGGVEFVKSKFILIAVGGRPSYPEDIPEIEKKVITSDDLFWL 182

Query: 177 KEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKI 236
              PGKTLVVGASYVALEC GF+ G+G D  IMVRSILLRGFDQ++A KI ++M VES I
Sbjct: 183 PNNPGKTLVVGASYVALECGGFLNGLGCDSSIMVRSILLRGFDQEIAGKIEDYM-VESGI 241

Query: 237 EFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           +FI+  +P +I  +E+ + LV W    G    + FDTVL ATGR  D +KL L++ GVK 
Sbjct: 242 KFIKEAIPINIEVIEHNRRLVTW-KQKGVQHSDTFDTVLIATGRKSDTSKLNLERVGVKT 300

Query: 297 NPKTGRIWVENEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           N     I   +++TS  N+YAIGD ++  PELTP AI+ G+LLA RL+  +  +M Y  +
Sbjct: 301 NKNGKIICTIDDRTSVANIYAIGDCVEGRPELTPTAIKCGQLLANRLFGGQKKMMCYQFI 360

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC G SEE +I KF ++ + IYH  F PLEW+L  +    A +C +K+I 
Sbjct: 361 PTTVFTPLEYGCIGYSEEEAINKFTQNEIIIYHSIFKPLEWNLLES--HYAQACMIKLIV 418

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             S  + V+G HYLGPNAGEV Q   +A+KLG T +Q    +GIHPT +E   TL   K
Sbjct: 419 MVS-TRRVIGLHYLGPNAGEVVQGYAVAIKLGATKEQFDATIGIHPTCSEEILTLTAVK 476


>gb|EAX03015.1| hCG17888, isoform CRA_c [Homo sapiens]
          Length = 463

 Score =  429 bits (1102), Expect = e-118
 Identities = 227/450 (50%), Positives = 307/450 (68%), Gaps = 32/450 (7%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 80  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 138

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 139 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 197

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 198 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT-RF 256

Query: 239 IRGCVPQSIMKLENGQLLVKWT-TADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 257 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 316

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 317 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 376

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 377 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 433

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMK 445
            +   + V+G H+LGPNAGEVTQ   L +K
Sbjct: 434 LREPPQLVLGLHFLGPNAGEVTQGFALGIK 463


>ref|XP_003137903.1| thioredoxin reductase [Loa loa]
 gb|EFO26173.1| thioredoxin reductase [Loa loa]
          Length = 637

 Score =  428 bits (1100), Expect = e-117
 Identities = 240/488 (49%), Positives = 323/488 (66%), Gaps = 21/488 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YDL V+GGGSGGLA +KEA + GKKV  LD+VKPS +GT+WGLGGTCVNVGCIPKKLM
Sbjct: 145 HQYDLAVVGGGSGGLAAAKEAVRLGKKVVCLDFVKPSTMGTTWGLGGTCVNVGCIPKKLM 204

Query: 62  HQSSLIGETIHKDSKAFGWTV--GEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYE 119
           HQ++L+GE I +D+K FGW +  G    +W Q+  ++ ++I S+N+ Y+V+LR++ V Y 
Sbjct: 205 HQAALLGEYI-EDAKKFGWEIPEGAIKLNWHQLKNAIQNHITSLNWAYRVQLRERSVTYM 263

Query: 120 NLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPKPLACEGG-DLAISSDDIFWRKE 178
           N   +F  +H L + + K   + VT    +IAVG RP+     G  +  ISSDD+F    
Sbjct: 264 NSYATFTGSHELSVKNKKGKVEKVTADRFLIAVGLRPRFPDVPGVLECCISSDDLFSLPY 323

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
            PGKTL VGASYV+LECAGF++G+G DV +MVRSILLRG DQDMA++I + M +E  ++F
Sbjct: 324 NPGKTLCVGASYVSLECAGFLRGIGNDVTVMVRSILLRGLDQDMAERIKKHM-IEHGVKF 382

Query: 239 IRGCVPQSIMKLE----NGQLLVKWTTA----DG--EACEEAFDTVLNATGRDPDVAKLG 288
           +   +P    KL+    N   L++  T     DG  E   E F+TVL A GRD     LG
Sbjct: 383 V-PYIPIKYEKLKEPTNNEPGLIRVHTVQEREDGTKEEVAEEFNTVLMAIGRDAMTGDLG 441

Query: 289 LDKAGVKLNPKTGRIWVENEQT-STPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNE 346
           LD  GV    + G+I    EQ+ S P VYAIGDV+  +PELTPVAIQAG++L RRL+   
Sbjct: 442 LDLVGVDCT-EFGKIIGRREQSVSCPYVYAIGDVLHGSPELTPVAIQAGKVLMRRLFTGN 500

Query: 347 TTLMDYDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAA 406
           + L +Y KV T VFTP+EYG CGLSE+A+I+K+G++N+ +YH  F PLE++++   R   
Sbjct: 501 SELTEYGKVPTTVFTPLEYGSCGLSEDAAIQKYGKENINVYHNMFIPLEYAVTE--RKEK 558

Query: 407 SSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEI 466
           + CY K+IC K     V+GFH L PNAGE+TQ   +A+K          ++GIHPT AE 
Sbjct: 559 THCYCKLICLKKEQDLVLGFHILAPNAGEITQGFAIALKFDAKKADFDRLIGIHPTVAEN 618

Query: 467 FTTLEVTK 474
           FTTL + K
Sbjct: 619 FTTLTLLK 626


>ref|XP_001459173.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK91776.1| unnamed protein product [Paramecium tetraurelia]
          Length = 475

 Score =  427 bits (1099), Expect = e-117
 Identities = 239/480 (49%), Positives = 309/480 (64%), Gaps = 16/480 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           Y YD+ VIGGGSGGL    EA + GK+V + DY+KPS  GT WG GGTC NVGCIPKKLM
Sbjct: 5   YQYDIFVIGGGSGGLTVVDEAQRLGKRVGLADYIKPSPHGTQWGTGGTCPNVGCIPKKLM 64

Query: 62  HQSSLIGETIHKDSKAFGWTVGE--QTFDWAQMLKSVNSYIKSINFKYKVEL-RDKKVKY 118
           H ++LIGE  H +  A GW   +     DW  ++  V   +K IN      L     + Y
Sbjct: 65  HMTALIGEIRH-ELTATGWQGVDPHSKNDWNILVNEVQRQVKGINKGNDDWLIATNGITY 123

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEG-GDLAISSDDIFWR 176
            N LG   D HT+EL      ++ VT   +VIAVG RP  P        L I+SDD+F  
Sbjct: 124 YNKLGKLKDDHTIELIDKDGQSEFVTAEYIVIAVGSRPSFPTDIPNVKQLTITSDDLFSL 183

Query: 177 KEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKI 236
           K+APGKTLVVGASYVALECAGF+ G+GYDV +MVRSILLRGFDQ+MA++IGEFM++    
Sbjct: 184 KKAPGKTLVVGASYVALECAGFLTGLGYDVTVMVRSILLRGFDQEMAERIGEFMKIHG-T 242

Query: 237 EFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           +FIRG +P SI  ++ G+ LVKW   +G+   E FDTVL A GR  D   LGL++ GV+ 
Sbjct: 243 KFIRGTIPSSIEDVD-GKRLVKW-VLNGQEQSEVFDTVLLAIGRSADTQNLGLEQVGVQT 300

Query: 297 NPKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           N ++G+I   + + TS PN++AIGD +    ELTP AI  G+ L +RLY+N   +M+Y  
Sbjct: 301 NKESGKIIANDADSTSVPNIFAIGDCVQGRLELTPTAIMCGKRLIKRLYSNGNQIMEYSD 360

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EYGC G SEEA+I+KFG+DNL+I+   FTPL W+ ++       +CY K+I
Sbjct: 361 VSTTVFTPLEYGCVGYSEEAAIQKFGKDNLKIFTSEFTPLFWNFAN----RKGTCYAKLI 416

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             K  D  V+GFHYLGP+A EVTQ  G+ +KL      + NVVGIHP+ AE    ++  K
Sbjct: 417 VKKD-DDVVIGFHYLGPDAAEVTQGFGVVIKLKAKKSDLDNVVGIHPSVAEELVQMQTWK 475


>ref|XP_745009.1| Thioredoxin reductase [Plasmodium chabaudi chabaudi]
 emb|CAH79243.1| Thioredoxin reductase, putative [Plasmodium chabaudi chabaudi]
          Length = 532

 Score =  427 bits (1098), Expect = e-117
 Identities = 230/489 (47%), Positives = 311/489 (63%), Gaps = 23/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYD +VIGGG GG+A +KEAA +G KV + D+VKPS  GT WG+GGTCVNVGC+PKKLM
Sbjct: 31  YDYDYIVIGGGPGGMASAKEAASHGAKVLLFDFVKPSTQGTKWGIGGTCVNVGCVPKKLM 90

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           H +  +G     DS+ +GW       DW +++ +V S+I+S+NF Y V L+  KVKY N 
Sbjct: 91  HYAGNMGTLFKNDSEKYGWDCDNLKHDWNKLVSTVQSHIRSLNFSYMVGLKSSKVKYING 150

Query: 122 LGSFIDAHTLELWHPKKGTK--TVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           L    D +T+  +     +K   VT + +++A G RP  P    G  +L+I+SDDIF  K
Sbjct: 151 LAKLKDKNTVSYYLKGDTSKEECVTGKYILVATGCRPNIPDDVIGAKELSITSDDIFSLK 210

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGASYVALECAGF+  +GYDV I VRSI+LRGFDQ  A+KI  +ME E  + 
Sbjct: 211 RCPGKTLVVGASYVALECAGFLNSLGYDVTISVRSIILRGFDQQCANKIKLYME-EQGVT 269

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           F+ G +P+ + K EN ++LV +         E FDTVL A GR  D+  L L+K  + +N
Sbjct: 270 FMTGVLPKKLTK-ENDKILVHF----NNDTTEVFDTVLYAIGRKGDIDGLNLEKLNININ 324

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
               +I  +    T+ PN++A+GD+ +  PEL PVAI+AG +LARRL+ N   +M YD +
Sbjct: 325 NNNKKIIADQFSCTNIPNIFAVGDIAENVPELAPVAIKAGEILARRLFKNSNEIMKYDFI 384

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR-----------P 404
            T+++TPIEYG CG SEE + E FG++N+E++ Q F  LE S     +            
Sbjct: 385 PTSIYTPIEYGSCGYSEEKAYEIFGKNNIEVFLQEFNNLEISAVHRIKHIKAQKDEYDVD 444

Query: 405 AASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTA 464
            +S+C+ K++C K+ D  VVGFHY+GPNAGEVTQ M LA+KL        N +GIHPT A
Sbjct: 445 ISSTCFSKLVCLKNEDNRVVGFHYVGPNAGEVTQGMALALKLNAKKSDFDNCIGIHPTDA 504

Query: 465 EIFTTLEVT 473
           E F  L +T
Sbjct: 505 ESFMNLTIT 513


>gb|EDK97526.1| thioredoxin reductase 2, isoform CRA_c [Mus musculus]
          Length = 498

 Score =  426 bits (1096), Expect = e-117
 Identities = 230/477 (48%), Positives = 308/477 (64%), Gaps = 42/477 (8%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 47  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 106

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 107 AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 165

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 166 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 225

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 226 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 284

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 285 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 344

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V  
Sbjct: 345 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNV-- 402

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
                                        YH  + PLE++++      AS CY+K++C +
Sbjct: 403 -----------------------------YHAYYKPLEFTVADRD---ASQCYIKMVCMR 430

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 431 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 487


>ref|XP_001166546.1| PREDICTED: thioredoxin reductase 2 isoform 2 [Pan troglodytes]
          Length = 463

 Score =  426 bits (1096), Expect = e-117
 Identities = 226/450 (50%), Positives = 305/450 (67%), Gaps = 32/450 (7%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 80  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 138

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF+D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 139 KASFVDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 197

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PGKTLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 198 SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT-RF 256

Query: 239 IRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W     G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 257 LRGCAPSRVRRLPDGQLQVTWEDCTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 316

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YA+GDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 317 PDTQKILVDSREATSVPHIYAVGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 376

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++   G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 377 PTTVFTPLEYGCVGLSEEEAVAHHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 433

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMK 445
            +   + V+G H+LGPNAGEVTQ   L +K
Sbjct: 434 LREPPQLVLGLHFLGPNAGEVTQGFALGIK 463


>gb|AAQ03230.1|AF412308_1 mitochondrial thioredoxin reductase 2 [Mus musculus]
          Length = 496

 Score =  426 bits (1096), Expect = e-117
 Identities = 230/477 (48%), Positives = 308/477 (64%), Gaps = 42/477 (8%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA+ GKKV V DYV+PS  GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 43  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 102

Query: 64  SSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENLL 122
           ++L+G  I +D+  +GW V +    +W  M ++V +++KS+N+ ++V+L+D+KVKY N+ 
Sbjct: 103 AALLGGMI-RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 161

Query: 123 GSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRKEAP 180
            SF+D HT+           ++   +VIA GGRP+ P   +G  +  I+SDDIFW KE+P
Sbjct: 162 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 221

Query: 181 GKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEFIR 240
           GKTLVVGASYVALECAGF+ G+G D  +M+RSI LRGFDQ M+  + E ME     +F++
Sbjct: 222 GKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG-TQFLK 280

Query: 241 GCVPQSIMKLENGQLLVKWTT-ADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLNPK 299
           GCVP  I KL   QL V W   A G+     FDTVL A GR P+   L L+KAG+  NPK
Sbjct: 281 GCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 340

Query: 300 TGRIWVE-NEQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKVCT 357
             +I V+  E TS P++YAIGDV +  PELTP AI+AG+LLA+RL+   +TLMDY  V  
Sbjct: 341 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNV-- 398

Query: 358 AVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVICDK 417
                                        YH  + PLE++++      AS CY+K++C +
Sbjct: 399 -----------------------------YHAYYKPLEFTVADRD---ASQCYIKMVCMR 426

Query: 418 SRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
              + V+G H+LGPNAGEVTQ   L +K G +Y Q++  VGIHPT +E    L ++K
Sbjct: 427 EPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISK 483


>dbj|BAG53517.1| unnamed protein product [Homo sapiens]
          Length = 463

 Score =  424 bits (1091), Expect = e-116
 Identities = 226/450 (50%), Positives = 306/450 (68%), Gaps = 32/450 (7%)

Query: 3   DYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGETIHKDSKAFGWTVGEQT-FDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           Q++L+G  I +D+  +GW V +    DW +M ++V +++KS+N+ ++V+L+D+KVKY N+
Sbjct: 80  QAALLGGLI-QDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 138

Query: 122 LGSFIDAHTLELWHPKKGTKTVTTRD-VVIAVGGRPK-PLACEGG-DLAISSDDIFWRKE 178
             SF D HT+     K G + + + D ++IA GGRP+ P   EG  +  I+SDDIFW KE
Sbjct: 139 KASFGDEHTV-CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKE 197

Query: 179 APGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIEF 238
           +PG+TLVVGASYVALECAGF+ G+G D  IM+RSI LRGFDQ M+  + E M       F
Sbjct: 198 SPGETLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGT-RF 256

Query: 239 IRGCVPQSIMKLENGQLLVKWT-TADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           +RGC P  + +L +GQL V W  +  G+     FDTVL A GR PD   L L+KAGV  +
Sbjct: 257 LRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTS 316

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVIDA-PELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
           P T +I V++ E TS P++YAIGDV++  PELTP AI AGRLL +RL+   + LMDYD V
Sbjct: 317 PDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYDNV 376

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVIC 415
            T VFTP+EYGC GLSEE ++ + G++++E+YH ++ PLE++++      AS CYVK++C
Sbjct: 377 PTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKMVC 433

Query: 416 DKSRDKYVVGFHYLGPNAGEVTQAMGLAMK 445
            +   + V+G H+LGPNAGEVTQ   L +K
Sbjct: 434 LREPPQLVLGLHFLGPNAGEVTQGFALGIK 463


>emb|CAG09709.1| unnamed protein product [Tetraodon nigroviridis]
          Length = 472

 Score =  423 bits (1087), Expect = e-116
 Identities = 230/483 (47%), Positives = 318/483 (65%), Gaps = 34/483 (7%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLACSKEAA+ G+ V VLDYV+PS+ GT WGLGGTCVNVGCIPKKLM
Sbjct: 3   YDYDLVVIGGGSGGLACSKEAAQLGQNVAVLDYVEPSIKGTKWGLGGTCVNVGCIPKKLM 62

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQ-TFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           HQ++L+G  + KD+K +GW + E  + DWA M ++V ++++S+N+ ++V+L+DKKVKY N
Sbjct: 63  HQAALLGTAV-KDAKKYGWQIPEPISHDWAAMAEAVQNHVRSLNWGHRVQLQDKKVKYLN 121

Query: 121 LLGSFIDAHTLELWHPKKGTKTV-TTRDVVIAVGGRPK-----PLACEGGDLAISSDDIF 174
           + GS +D HT++    K G +T+ T +++VIA GGRPK     P A E G   I+SDDIF
Sbjct: 122 MRGSLVDEHTVK-GVTKAGKETILTAKNIVIATGGRPKYPTDIPGATEHG---ITSDDIF 177

Query: 175 WRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVES 234
           W +++PGKT     S VALECAGF+ G+G D  +MVRSI LRGFDQ MA  + ++ME   
Sbjct: 178 WLRKSPGKT-----SDVALECAGFLTGIGLDATVMVRSIALRGFDQQMAALVTDYMETYG 232

Query: 235 KIEFIRGCVPQSIMKLENGQLLVKWTTAD-GEACEEAFDTVLNATG--RDPDVAKLGLDK 291
             +F   C+P+ + K+ +G L V WT  +  +  ++ +D VL A G    P       +K
Sbjct: 233 -TKFAWKCIPKRVEKMPSGALQVTWTDLNTSKEQQDTYDCVLWAVGIPTKPQQRPSPRNK 291

Query: 292 AGVKLNPKTGRIWVENEQTSTPNVYAIGDVIDAPELTPVAIQAGRLLARRLYNNETTLMD 351
                NP +G+ W          ++    +   PELTP AI+AG+LLA RL    T LM+
Sbjct: 292 -----NPGSGQAWC----AKNVRIFFF-SLQGRPELTPTAIKAGKLLAHRLAGRSTELMN 341

Query: 352 YDKVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYV 411
           Y  V T VFTP+EYGC GLSEE + ++ G+D +E+YH  + PLE++++      AS CY+
Sbjct: 342 YHNVPTTVFTPLEYGCVGLSEEDAEKRHGKDRIEVYHAFYKPLEFTVAERD---ASQCYL 398

Query: 412 KVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLE 471
           KV+C+    + ++G H+ GPNAGEVTQ   L++K G TY  ++  VGIHPT AE    + 
Sbjct: 399 KVVCEGDGGQKILGLHFTGPNAGEVTQGFALSLKCGATYSHLLQTVGIHPTCAEEVIKVN 458

Query: 472 VTK 474
           +TK
Sbjct: 459 ITK 461


>emb|CBZ54959.1| MGC84926 protein, related [Neospora caninum Liverpool]
          Length = 528

 Score =  422 bits (1086), Expect = e-116
 Identities = 236/492 (47%), Positives = 316/492 (64%), Gaps = 23/492 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL VIGGGSGGLAC+K AA +G K  V D+V+PS  G++WGLGGTCVNVGC+PK L 
Sbjct: 23  FDYDLAVIGGGSGGLACAKMAAAHGAKTVVFDFVQPSTQGSTWGLGGTCVNVGCVPKYLF 82

Query: 62  HQSSLIGETIHKDSKAFGWT-VGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H ++L+G+  H D    GW    E+  DW+  ++ V +Y+KS+NF Y+  LR   V Y N
Sbjct: 83  HHTALVGKGAHCDGPHMGWQGKFEEQIDWSVCVEKVQNYVKSLNFGYRTGLRKAGVTYIN 142

Query: 121 LLGSFIDAHTLELWHPKKG-TKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
               F   H  EL +  +G  K    R++V+A GGRP  P   EG  +LAI+SDDIF  K
Sbjct: 143 AYAKFASPH--ELAYTFRGEEKICKARNIVVAAGGRPHIPEEVEGAKELAITSDDIFSLK 200

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           +AP KTL VGASY++LECAGF++ +G+DV + VRSILLRGFD+  A+++G  +E E+ + 
Sbjct: 201 QAPNKTLCVGASYISLECAGFLRELGFDVTVAVRSILLRGFDRQCAEQVGLCLE-EAGVR 259

Query: 238 FIRGCVPQSIMKLENGQLLVKWT--TADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVK 295
           F+R  VP  ++K  +G++ V +   TA+ +   E FDTVL ATGR  D +KL L  AGV+
Sbjct: 260 FLREAVPVKMVKQPSGKIQVTFRVGTAEPKELVEEFDTVLYATGRKADTSKLNLQAAGVE 319

Query: 296 LNPKTGRIWVENE-QTSTPNVYAIGDVI-DAPELTPVAIQAGRLLARRLYNNETTLMDYD 353
              +TG+I  +++  TS+P+VYAIGD + + PELTPVAI+AG +LARRL+ N T  MD+ 
Sbjct: 320 -TTETGKIICDDDSHTSSPSVYAIGDAVQNFPELTPVAIKAGEILARRLFANSTEHMDFT 378

Query: 354 KVCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSL-----------SSAT 402
            + T VFTPIEY   G SEE +  KFG D+LEIY   F+PL +S            S   
Sbjct: 379 NIPTTVFTPIEYAHTGYSEETAEAKFGRDDLEIYLFQFSPLFFSCVHREKAEIARKSPED 438

Query: 403 RPAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPT 462
                 C  K+IC KS D+ VVG H++GPNAGE+ Q   LA++LG         +GIHPT
Sbjct: 439 VDITPPCLAKLICVKSEDEKVVGIHFVGPNAGELMQGFALAVRLGAKKRDFDKCIGIHPT 498

Query: 463 TAEIFTTLEVTK 474
            AE F  L +TK
Sbjct: 499 NAEAFMALTITK 510


>ref|XP_730274.1| thioredoxin reductase [Plasmodium yoelii yoelii str. 17XNL]
 gb|EAA21839.1| thioredoxin reductase [Plasmodium yoelii yoelii]
          Length = 638

 Score =  422 bits (1084), Expect = e-116
 Identities = 229/489 (46%), Positives = 310/489 (63%), Gaps = 23/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYD +VIGGG GG+A +KEAA +G KV + D+VKPS  GT WG+GGTCVNVGC+PKKLM
Sbjct: 137 YDYDYIVIGGGPGGMASAKEAASHGAKVLLFDFVKPSSQGTKWGIGGTCVNVGCVPKKLM 196

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           H +  +G     DS  +GW       DW +++ +V S+I+S+NF Y V L+  KVKY N 
Sbjct: 197 HYAGNMGTLFKSDSDKYGWECDNLKHDWNKLVSTVQSHIRSLNFSYMVGLKSSKVKYING 256

Query: 122 LGSFIDAHTLELWHPKKGTK--TVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           L    D +T+  +     +K   VT + ++IA G RP  P    G  +L+I+SDDIF  K
Sbjct: 257 LAKLKDKNTVSYYLKGDTSKEDCVTGKYILIATGCRPNIPDDVIGAKELSITSDDIFSLK 316

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           + PGKTLVVGASYVALECAGF+  +G D  I VRSI+LRGFDQ  A+KI  +ME E  + 
Sbjct: 317 KNPGKTLVVGASYVALECAGFLNSLGCDTTISVRSIILRGFDQQCANKIKLYME-EQGVT 375

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           F+ G +P+ + K EN ++LV +         E FDTVL A GR  D+  L L+K  + +N
Sbjct: 376 FMCGVLPKKLTK-ENDKILVHF----NNNTTELFDTVLYAIGRKGDIDGLNLEKLNININ 430

Query: 298 PKTGRIWVEN-EQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
               +I  +    T+ PN++A+GD+ +  PEL PVAI+AG +LARRL+ N   +M Y+ +
Sbjct: 431 NNNNKIITDKFSCTNIPNIFAVGDIAENVPELAPVAIKAGEILARRLFKNSNEIMKYNLI 490

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR-----------P 404
            T+++TPIEYG CG SEE + E+FG++N+EI+ Q F  LE S    T+            
Sbjct: 491 PTSIYTPIEYGSCGYSEEQAYEQFGKNNIEIFLQEFNNLEISAVHRTKHLKVQKDEYDVD 550

Query: 405 AASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTA 464
            +S+C  K++C K+ D  V+GFHY+GPNAGEVTQ M LA+KL        N +GIHPT A
Sbjct: 551 ISSTCLSKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALKLNAKKSDFDNCIGIHPTDA 610

Query: 465 EIFTTLEVT 473
           E F  L +T
Sbjct: 611 ESFMNLSIT 619


>ref|XP_002808951.1| thioredoxin reductase [Plasmodium falciparum 3D7]
 sp|P61076|TRXR2_PLAF7 RecName: Full=Thioredoxin reductase 2; Short=TrxR2
 gb|AAQ07981.1|AF508128_1 thioredoxin reductase 2 [Plasmodium falciparum]
 emb|CAX64232.1| thioredoxin reductase [Plasmodium falciparum 3D7]
          Length = 617

 Score =  421 bits (1082), Expect = e-115
 Identities = 227/490 (46%), Positives = 315/490 (64%), Gaps = 23/490 (4%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYD VVIGGG GG+A +KEAA +G +V + DYVKPS  GT WG+GGTCVNVGC+PKKL
Sbjct: 115 TYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKL 174

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH +  +G     DSKA+GW       DW +++ +V S+I+S+NF Y   LR  KVKY N
Sbjct: 175 MHYAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYIN 234

Query: 121 LLGSFIDAHTLELWHPKKGTK--TVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWR 176
            L    D +T+  +     +K  TVT + ++IA G RP  P   EG  +L+I+SDDIF  
Sbjct: 235 GLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDIFSL 294

Query: 177 KEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKI 236
           K+ PGKTLVVGASYVALEC+GF+  +GYDV + VRSI+LRGFDQ  A K+  +ME E  +
Sbjct: 295 KKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYME-EQGV 353

Query: 237 EFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
            F  G +P+ + K+++ ++LV+++    +   E +DTVL A GR  D+  L L+   + +
Sbjct: 354 MFKNGILPKKLTKMDD-KILVEFS----DKTSELYDTVLYAIGRKGDIDGLNLESLNMNV 408

Query: 297 NPKTGRIWVEN-EQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           N    +I  ++   T+ P+++A+GDV +  PEL PVAI+AG +LARRL+ +   +MDY  
Sbjct: 409 NKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIMDYSY 468

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR----------- 403
           + T+++TPIEYG CG SEE + E +G+ N+E++ Q F  LE S     +           
Sbjct: 469 IPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKDEYDL 528

Query: 404 PAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTT 463
             +S+C  K++C K+ D  V+GFHY+GPNAGEVTQ M LA++L        N +GIHPT 
Sbjct: 529 DVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGIHPTD 588

Query: 464 AEIFTTLEVT 473
           AE F  L VT
Sbjct: 589 AESFMNLFVT 598


>sp|Q25861|TRXR_PLAF5 RecName: Full=Thioredoxin reductase; Short=TrxR
 emb|CAA60574.1| thioredoxin reductase [Plasmodium falciparum]
          Length = 541

 Score =  421 bits (1082), Expect = e-115
 Identities = 227/490 (46%), Positives = 315/490 (64%), Gaps = 23/490 (4%)

Query: 1   TYDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKL 60
           TYDYD VVIGGG GG+A +KEAA +G +V + DYVKPS  GT WG+GGTCVNVGC+PKKL
Sbjct: 39  TYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKL 98

Query: 61  MHQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           MH +  +G     DSKA+GW       DW +++ +V S+I+S+NF Y   LR  KVKY N
Sbjct: 99  MHYAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYIN 158

Query: 121 LLGSFIDAHTLELWHPKKGTK--TVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWR 176
            L    D +T+  +     +K  TVT + ++IA G RP  P   EG  +L+I+SDDIF  
Sbjct: 159 GLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDIFSL 218

Query: 177 KEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKI 236
           K+ PGKTLVVGASYVALEC+GF+  +GYDV + VRSI+LRGFDQ  A K+  +ME E  +
Sbjct: 219 KKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYME-EQGV 277

Query: 237 EFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
            F  G +P+ + K+++ ++LV+++    +   E +DTVL A GR  D+  L L+   + +
Sbjct: 278 MFKNGILPKKLTKMDD-KILVEFS----DKTSELYDTVLYAIGRKGDIDGLNLESLNMNV 332

Query: 297 NPKTGRIWVEN-EQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           N    +I  ++   T+ P+++A+GDV +  PEL PVAI+AG +LARRL+ +   +MDY  
Sbjct: 333 NKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIMDYSY 392

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR----------- 403
           + T+++TPIEYG CG SEE + E +G+ N+E++ Q F  LE S     +           
Sbjct: 393 IPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKDEYDL 452

Query: 404 PAASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTT 463
             +S+C  K++C K+ D  V+GFHY+GPNAGEVTQ M LA++L        N +GIHPT 
Sbjct: 453 DVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGIHPTD 512

Query: 464 AEIFTTLEVT 473
           AE F  L VT
Sbjct: 513 AESFMNLFVT 522


>ref|XP_679935.1| Thioredoxin reductase [Plasmodium berghei strain ANKA]
 emb|CAH95193.1| Thioredoxin reductase, putative [Plasmodium berghei]
          Length = 542

 Score =  418 bits (1074), Expect = e-114
 Identities = 229/489 (46%), Positives = 309/489 (63%), Gaps = 24/489 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           YDYD +VIGGG GG+A +KEAA +G KV + D+VKPS  GT WG+GGTCVNVGC+PKKLM
Sbjct: 42  YDYDYIVIGGGPGGMASAKEAASHGAKVLLFDFVKPSSQGTKWGIGGTCVNVGCVPKKLM 101

Query: 62  HQSSLIGETIHKDSKAFGWTVGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYENL 121
           H +  +G     DS  +GW       DW +++ +V S+I+S+NF Y + L+  KVKY N 
Sbjct: 102 HYAGNMGTLFKNDSDKYGWECNNLKHDWNKLVSTVQSHIRSLNFSYMIGLK-SKVKYING 160

Query: 122 LGSFIDAHTLELWHPKKGTK--TVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
           L    + +T+  +     +K   VT + ++IA G RP  P    G  +L+I+SDDIF  K
Sbjct: 161 LAKLKNKNTVSYYLKGDSSKEDCVTGKYILIATGCRPNIPDDVIGAKELSITSDDIFSLK 220

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
             PGKTLVVGASYVALECAGF+  +GYD  + VRSI+LRGFDQ  A+KI  +ME E  + 
Sbjct: 221 NDPGKTLVVGASYVALECAGFLNSLGYDTTVSVRSIILRGFDQQCANKIKLYME-EQGVT 279

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKLN 297
           F+ G +P+ + K EN ++LV +         E FDTVL A GR  D+  L L+K  + +N
Sbjct: 280 FMCGILPKKLTK-ENDKILVHF----NNNTTELFDTVLYAIGRKGDIDGLNLEKLNININ 334

Query: 298 PKTGRIWV-ENEQTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDKV 355
               +I   E   T+ PN++A+GD+ +  PEL PVAI+AG +LARRL+ N   +M Y+ +
Sbjct: 335 SNNNKIITDEFSCTNIPNIFAVGDIAENVPELAPVAIKAGEILARRLFKNSNEIMKYNFI 394

Query: 356 CTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATR-----------P 404
            T+++TPIEYG CG SEE + E FG++N+EI+ Q F  LE S    T+            
Sbjct: 395 PTSIYTPIEYGSCGYSEEKAYELFGKNNIEIFLQEFNNLEISAVHRTKHIKAQKDEYDVD 454

Query: 405 AASSCYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTA 464
            +S+C  K++C K+ D  VVGFHY+GPNAGEVTQ M LA+KL        N +GIHPT A
Sbjct: 455 ISSTCLSKLVCLKNEDNRVVGFHYVGPNAGEVTQGMALALKLNAKKSDFDNCIGIHPTDA 514

Query: 465 EIFTTLEVT 473
           E F  L +T
Sbjct: 515 ESFMNLSIT 523


>gb|EEE25525.1| thioredoxin reductase, putative [Toxoplasma gondii GT1]
          Length = 662

 Score =  417 bits (1071), Expect = e-114
 Identities = 236/491 (48%), Positives = 310/491 (63%), Gaps = 22/491 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL VIGGGSGGLAC+K AA  G K  V D+V+PS  G++WGLGGTCVNVGC+PK L 
Sbjct: 158 FDYDLAVIGGGSGGLACAKMAAAQGAKTVVFDFVQPSTQGSTWGLGGTCVNVGCVPKYLF 217

Query: 62  HQSSLIGETIHKDSKAFGWT-VGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H + L G   H D    GW    E+  DW   ++ V +YIKS+NF Y+  LR   V Y N
Sbjct: 218 HHTGLAGANAHWDGPHMGWKGKFEEQVDWGVCVEKVQNYIKSLNFGYRTGLRKAGVTYIN 277

Query: 121 LLGSFIDAHTLELWHPKKG-TKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
               F+  H  EL +  +G  K    R++V+AVGGRP  P   EG  +LAI+SDDIF  K
Sbjct: 278 AYAKFVSPH--ELAYTFRGEDKICKARNIVVAVGGRPHIPEEVEGAKELAITSDDIFSLK 335

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           +AP KTL VGASY++LECAGF++ +G+DV + VRSILLRGFD+  A+++G  +E E+ + 
Sbjct: 336 QAPNKTLCVGASYISLECAGFLRELGFDVTVAVRSILLRGFDRQCAEQVGLCLE-EAGVR 394

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTA-DGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
            +R  +P  ++K  NG++ V +    + +   E FDTVL ATGR  D + L L  AGV+ 
Sbjct: 395 ILRETIPAKMVKQANGKIQVTFQVGKEKKELVEEFDTVLYATGRKADTSNLNLQAAGVE- 453

Query: 297 NPKTGRIWVENE-QTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +TG+I  + +  TS P+VYAIGD ++  PELTPVAI+AG +LARRL+ N T  MD+  
Sbjct: 454 TTETGKIVCDGDSHTSAPSVYAIGDAVENFPELTPVAIKAGEILARRLFANSTEHMDFTN 513

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWS-LSSATRPAASS----- 408
           + T VFTPIEY   G SEEA+  +FG D+LE+Y   F+PL +S +     P A       
Sbjct: 514 IPTTVFTPIEYAHTGYSEEAAEAEFGRDDLEVYLFQFSPLFFSCVHREKAPQARKSPEDV 573

Query: 409 -----CYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTT 463
                C  K+IC KS D+ VVG H++GPNAGE+ Q   LA++LG         VGIHPT 
Sbjct: 574 DITPPCLAKLICVKSEDEKVVGIHFVGPNAGELMQGFALAVRLGAKKRDFDKCVGIHPTN 633

Query: 464 AEIFTTLEVTK 474
           AE F  L VTK
Sbjct: 634 AEAFMALTVTK 644


>ref|XP_001452173.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK84776.1| unnamed protein product [Paramecium tetraurelia]
          Length = 475

 Score =  416 bits (1070), Expect = e-114
 Identities = 234/480 (48%), Positives = 306/480 (63%), Gaps = 16/480 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           + YD+ VIGGGSGGL    EA K GK+V + DY+KPS  GT WG GGTC NVGCIPKKLM
Sbjct: 5   FQYDIFVIGGGSGGLTVVDEAQKLGKRVGLADYIKPSPHGTQWGTGGTCPNVGCIPKKLM 64

Query: 62  HQSSLIGETIHKDSKAFGWTVGE--QTFDWAQMLKSVNSYIKSINFKYKVEL-RDKKVKY 118
           H ++LIGE  H +  A GW   +     +W  ++  V   +K IN      L     + Y
Sbjct: 65  HMTALIGEIRH-ELTATGWQGVDPHSKHNWNTLVNEVQRQVKGINKGNDDWLVTTNGITY 123

Query: 119 ENLLGSFIDAHTLELWHPKKGTKTVTTRDVVIAVGGRPK-PLACEG-GDLAISSDDIFWR 176
            N LG   D HT+EL      ++ VT   +VIAVG RP  P        L I+SDD+F  
Sbjct: 124 YNKLGKLKDDHTIELIDKDGQSEFVTAEYIVIAVGSRPSFPTDIPNVKQLTITSDDLFSL 183

Query: 177 KEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKI 236
           K APGKTLVVGASYVALECAGF+ G+GYDV +MVRSILLRGFDQ++A++IGEFM++ S  
Sbjct: 184 KNAPGKTLVVGASYVALECAGFLTGLGYDVTVMVRSILLRGFDQEIAERIGEFMKI-SGT 242

Query: 237 EFIRGCVPQSIMKLENGQLLVKWTTADGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
           +FIRG +P SI  ++ G+ LVKW   +G+   + FDTVL A GR  D   LGL++ GV+ 
Sbjct: 243 KFIRGTIPSSIEDVD-GKRLVKW-VLNGQEQTDVFDTVLLAIGRSADTQNLGLEQVGVET 300

Query: 297 NPKTGRIWVEN-EQTSTPNVYAIGDVIDAP-ELTPVAIQAGRLLARRLYNNETTLMDYDK 354
           N ++G+I   + + TS  N++AIGD +    ELTP AI  G+ L +RLY N   +M+Y  
Sbjct: 301 NKESGKIIANDADSTSVSNIFAIGDCVQGRLELTPTAIMCGKRLIKRLYQNGNQIMEYSD 360

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASSCYVKVI 414
           V T VFTP+EYGC G SEEA+ +KFG++NL+I+   FTPL W+ ++       +CY K+I
Sbjct: 361 VSTTVFTPLEYGCVGYSEEAATKKFGKENLKIFTSEFTPLFWNFAN----RKGTCYSKLI 416

Query: 415 CDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
             K  D  V+GFHYLGP+A EVTQ  G+ +KL      + NVVGIHP+ AE    ++  K
Sbjct: 417 V-KKEDDVVIGFHYLGPDAAEVTQGFGVVIKLKAKKSDLDNVVGIHPSVAEELVQMQTWK 475


>ref|XP_001031449.2| Pyridine nucleotide-disulphide oxidoreductase family protein
           [Tetrahymena thermophila]
 gb|EAR83786.2| Pyridine nucleotide-disulphide oxidoreductase family protein
           [Tetrahymena thermophila SB210]
          Length = 588

 Score =  416 bits (1068), Expect = e-114
 Identities = 239/524 (45%), Positives = 318/524 (60%), Gaps = 55/524 (10%)

Query: 4   YDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLMHQ 63
           YD+ +IGGGSGGLA + EA K G K  V D+V+ S  G SWGLGGTCVNVGCIPKKLMH 
Sbjct: 56  YDVAIIGGGSGGLAFAFEAQKLGMKAVVFDFVEESTQGNSWGLGGTCVNVGCIPKKLMHT 115

Query: 64  SSLIGETIHKDSKAFGWTVGEQTFD---------WAQMLKSVNSYIKSINFKYKVELRDK 114
           ++L  E I  +S  +G+ +  +  +         W  ++ +V SYIKSINF YK  L + 
Sbjct: 116 AALYKEVI-LNSSGYGFDLEGKNLEEKYKQEYLVWQHLVNNVQSYIKSINFGYKKSLGEL 174

Query: 115 KVKYENLLGSFIDAHTLELWHPKKGTKT------------------VTTRDVVIAVGGRP 156
            + Y N   SF D +TL ++ PK    +                  VT   +V+AVGGRP
Sbjct: 175 NIDYVNAFASFYDKNTL-VFSPKVDAISGFLKDNESYKANTEQLGYVTADKIVVAVGGRP 233

Query: 157 KPLA---CEGGD-LAISSDDIFWRKEAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRS 212
           + L+   C+  +  AI+SDDIF +K+ PGKTLV+G  Y+ALEC+GF+  +GYD  +M RS
Sbjct: 234 QLLSDSQCQNSNKYAITSDDIFMQKKPPGKTLVIGGGYIALECSGFLSTLGYDTTMMTRS 293

Query: 213 ILLRGFDQDMADKIGEFMEVESKIEFIRGCVPQSIMKLENGQLLVKWTTADGEA--CEEA 270
           + LR FDQD+A  I E ++  SK++ +   +P S+ K++   L VK    + ++   E+ 
Sbjct: 294 LYLREFDQDIAKMILENIQTHSKVKVVPTSLPVSLEKVDEDTLKVKIQNQEDKSKIYEDT 353

Query: 271 FDTVLNATGRDPDVAKLGLDKAGVKLNPKT----GRIWVENEQTSTPNVYAIGDVID-AP 325
           F+TVL A GR P+  KL L+K GV+LN K     GR   E EQTS   +YA+GDV+D  P
Sbjct: 354 FNTVLMAIGRKPNTQKLNLEKVGVQLNQKNKKIQGRFNDELEQTSVEGIYALGDVLDGVP 413

Query: 326 ELTPVAIQAGRLLARRLYNN-----------ETTLMDYDKVCTAVFTPIEYGCCGLSEEA 374
           ELTPVA + G+LLARR+ +            +   MDY+   T VFTP+EY C G SE+ 
Sbjct: 414 ELTPVAQKQGQLLARRIQHKKENKEPNTVFIQKNSMDYNDFPTTVFTPVEYSCAGYSEKQ 473

Query: 375 SIEKFGEDNLEIYHQNFTPLEWSLSSATRPAASS----CYVKVICDKSRDKYVVGFHYLG 430
           ++EKFGE+N+E+YH  FTPLE  LS        +     Y KVIC+K  ++ VVG HYLG
Sbjct: 474 AVEKFGEENIEVYHSKFTPLEEQLSPRVDENFDTIYRKAYAKVICNKLDNERVVGIHYLG 533

Query: 431 PNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTTAEIFTTLEVTK 474
           PNAGEV Q  G+AMKLG T   +   VGIHPTTAE FT L +TK
Sbjct: 534 PNAGEVMQGYGVAMKLGMTKADLDRTVGIHPTTAEEFTNLSITK 577


>ref|XP_002364220.1| thioredoxin reductase, putative [Toxoplasma gondii ME49]
 gb|EEA97079.1| thioredoxin reductase, putative [Toxoplasma gondii ME49]
 gb|EEE32689.1| thioredoxin reductase, putative [Toxoplasma gondii VEG]
          Length = 662

 Score =  415 bits (1067), Expect = e-114
 Identities = 235/491 (47%), Positives = 310/491 (63%), Gaps = 22/491 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAAKYGKKVCVLDYVKPSLVGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL VIGGGSGGLAC+K AA  G +  V D+V+PS  G++WGLGGTCVNVGC+PK L 
Sbjct: 158 FDYDLAVIGGGSGGLACAKMAAAQGAETVVFDFVQPSTQGSTWGLGGTCVNVGCVPKYLF 217

Query: 62  HQSSLIGETIHKDSKAFGWT-VGEQTFDWAQMLKSVNSYIKSINFKYKVELRDKKVKYEN 120
           H + L G   H D    GW    E+  DW   ++ V +YIKS+NF Y+  LR   V Y N
Sbjct: 218 HHTGLAGANAHWDGPHMGWKGKFEEQVDWGVCVEKVQNYIKSLNFGYRTGLRKAGVTYIN 277

Query: 121 LLGSFIDAHTLELWHPKKG-TKTVTTRDVVIAVGGRPK-PLACEGG-DLAISSDDIFWRK 177
               F+  H  EL +  +G  K    R++V+AVGGRP  P   EG  +LAI+SDDIF  K
Sbjct: 278 AYAKFVSPH--ELAYTFRGEDKICKARNIVVAVGGRPHIPEEVEGAKELAITSDDIFSLK 335

Query: 178 EAPGKTLVVGASYVALECAGFMKGMGYDVKIMVRSILLRGFDQDMADKIGEFMEVESKIE 237
           +AP KTL VGASY++LECAGF++ +G+DV + VRSILLRGFD+  A+++G  +E E+ + 
Sbjct: 336 QAPNKTLCVGASYISLECAGFLRELGFDVTVAVRSILLRGFDRQCAEQVGLCLE-EAGVR 394

Query: 238 FIRGCVPQSIMKLENGQLLVKWTTA-DGEACEEAFDTVLNATGRDPDVAKLGLDKAGVKL 296
            +R  +P  ++K  NG++ V +    + +   E FDTVL ATGR  D + L L  AGV+ 
Sbjct: 395 ILRETIPAKMVKQANGKIQVTFQVGKEKKELVEEFDTVLYATGRKADTSNLNLQAAGVE- 453

Query: 297 NPKTGRIWVENE-QTSTPNVYAIGDVID-APELTPVAIQAGRLLARRLYNNETTLMDYDK 354
             +TG+I  + +  TS P+VYAIGD ++  PELTPVAI+AG +LARRL+ N T  MD+  
Sbjct: 454 TTETGKIVCDGDSHTSAPSVYAIGDAVENFPELTPVAIKAGEILARRLFANSTEHMDFTN 513

Query: 355 VCTAVFTPIEYGCCGLSEEASIEKFGEDNLEIYHQNFTPLEWS-LSSATRPAASS----- 408
           + T VFTPIEY   G SEEA+  +FG D+LE+Y   F+PL +S +     P A       
Sbjct: 514 IPTTVFTPIEYAHTGYSEEAAEAEFGRDDLEVYLFQFSPLFFSCVHREKAPQARKSPEDV 573

Query: 409 -----CYVKVICDKSRDKYVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVNVVGIHPTT 463
                C  K+IC KS D+ VVG H++GPNAGE+ Q   LA++LG         VGIHPT 
Sbjct: 574 DITPPCLAKLICVKSEDEKVVGIHFVGPNAGELMQGFALAVRLGAKKRDFDKCVGIHPTN 633

Query: 464 AEIFTTLEVTK 474
           AE F  L VTK
Sbjct: 634 AEAFMALTVTK 644


  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF excluding environmental samples
  from WGS projects
    Posted date:  Mar 15, 2011  4:40 PM
  Number of letters in database: 290,268,701
  Number of sequences in database:  13,389,222
  
Lambda     K      H
   0.318    0.136 5.30e-313 

Gapped
Lambda     K      H
   0.267   0.0410 5.30e-313 

Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 13389222
Number of Hits to DB: 223446571
Number of extensions: 9727522
Number of successful extensions: 27852
Number of sequences better than 10: 447
Number of HSP's better than 10 without gapping: 0
Number of HSP's gapped: 26467
Number of HSP's successfully gapped: 467
Length of query: 487
Length of database: 4585235997
Length adjustment: 143
Effective length of query: 344
Effective length of database: 2670577251
Effective search space: 918678574344
Effective search space used: 918678574344
T: 11
A: 40
X1: 16 (7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 83 (36.6 bits)

