BLASTP 2.2.16 [Mar-25-2007]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|199611737|gb|ABWE01000075.1|:subseq(6034,30000)
Hyaloperonospora parasitica strain Emoy2 v-7.0.1_Cont51.5, whole
genome shotgun sequence:[translate(1)]
         (493 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
           13,389,222 sequences; 290,268,701 total letters

Searching... please wait.. done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_002896377.1| thioredoxin reductase 1 [Phytophthora infest...   808   0.0  
ref|XP_001744219.1| hypothetical protein [Monosiga brevicollis M...   473   e-131
ref|XP_002798903.1| PREDICTED: thioredoxin reductase 1, cytoplas...   473   e-131
ref|NP_001025933.2| thioredoxin reductase 1 [Gallus gallus]           472   e-131
ref|NP_001116141.1| thioredoxin reductase 1, cytoplasmic [Pan tr...   471   e-131
ref|NP_001127133.1| thioredoxin reductase 1, cytoplasmic [Pongo ...   471   e-131
sp|Q5NVA2|TRXR1_PONAB RecName: Full=Thioredoxin reductase 1, cyt...   471   e-130
gb|AAL15432.1| thioredoxin reductase 1 [Homo sapiens]                 471   e-130
gb|AAB35418.1| thioredoxin reductase [Homo sapiens] >gi|1237038|...   471   e-130
ref|NP_777050.1| thioredoxin reductase 1, cytoplasmic [Bos tauru...   471   e-130
pdb|2ZZ0|A Chain A, Crystal Structure Of Human Thioredoxin Reduc...   471   e-130
dbj|BAH11961.1| unnamed protein product [Homo sapiens]                471   e-130
pdb|2J3N|A Chain A, X-Ray Structure Of Human Thioredoxin Reducta...   471   e-130
ref|NP_001087240.1| thioredoxin reductase 1, cytoplasmic isoform...   471   e-130
ref|NP_003321.3| thioredoxin reductase 1, cytoplasmic isoform 1 ...   471   e-130
gb|EAW97743.1| thioredoxin reductase 1 [Homo sapiens] >gi|119618...   471   e-130
gb|EAW97745.1| thioredoxin reductase 1 [Homo sapiens] >gi|221044...   471   e-130
pdb|2CFY|A Chain A, Crystal Structure Of Human Thioredoxin Reduc...   471   e-130
emb|CAA04503.1| thioredoxin reductase [Homo sapiens] >gi|5469614...   471   e-130
ref|NP_877393.1| thioredoxin reductase 1, cytoplasmic isoform 2 ...   471   e-130
gb|AAC69621.1| thioredoxin reductase GRIM-12 [Homo sapiens]           471   e-130
dbj|BAA13674.1| KM-102-derived reductase-like factor [Homo sapiens]   471   e-130
ref|NP_001131081.1| thioredoxin reductase 1 [Equus caballus]          470   e-130
pdb|1H6V|A Chain A, Mammalian Thioredoxin Reductase >gi|15826813...   470   e-130
ref|XP_003126688.1| PREDICTED: thioredoxin reductase 1, cytoplas...   470   e-130
gb|EDM17072.1| thioredoxin reductase 1, isoform CRA_b [Rattus no...   470   e-130
gb|EDM17071.1| thioredoxin reductase 1, isoform CRA_a [Rattus no...   470   e-130
gb|AAH85726.1| Txnrd1 protein [Rattus norvegicus]                     470   e-130
ref|NP_113802.2| thioredoxin reductase 1, cytoplasmic [Rattus no...   470   e-130
ref|XP_002181543.1| predicted protein [Phaeodactylum tricornutum...   469   e-130
pdb|3EAN|A Chain A, Crystal Structure Of Recombinant Rat Selenop...   469   e-130
emb|CAG38744.1| TXNRD1 [Homo sapiens]                                 469   e-130
ref|NP_898895.2| thioredoxin reductase 3 [Danio rerio]                469   e-130
gb|AAH54599.1| Thioredoxin reductase 1 [Danio rerio] >gi|1828921...   469   e-130
gb|AAI54785.1| Thioredoxin reductase 1 [Danio rerio]                  469   e-130
ref|NP_999319.2| thioredoxin reductase 1, cytoplasmic [Sus scrofa]    468   e-130
gb|AAN06824.1| thioredoxin reductase [Sus scrofa]                     468   e-130
ref|XP_002752975.1| PREDICTED: thioredoxin reductase 1, cytoplas...   467   e-129
ref|XP_002752974.1| PREDICTED: thioredoxin reductase 1, cytoplas...   467   e-129
dbj|BAC87474.1| unnamed protein product [Homo sapiens]                467   e-129
ref|XP_001507796.1| PREDICTED: similar to thioredoxin reductase ...   467   e-129
gb|AAF15900.1|AF208018_1 thioredoxin reductase [Homo sapiens]         466   e-129
sp|Q9MYY8|TRXR1_PIG RecName: Full=Thioredoxin reductase 1, cytop...   466   e-129
ref|NP_001087786.1| thioredoxin reductase 1 [Xenopus laevis] >gi...   466   e-129
gb|AAC35244.2| thioredoxin reductase [Rattus norvegicus]              465   e-129
ref|XP_001365687.1| PREDICTED: similar to Thioredoxin reductase ...   465   e-129
dbj|BAE26918.1| unnamed protein product [Mus musculus]                465   e-129
gb|EDL21377.1| thioredoxin reductase 1, isoform CRA_b [Mus muscu...   464   e-128
gb|AAH37643.1| Thioredoxin reductase 1 [Mus musculus] >gi|742122...   464   e-128
ref|NP_001035988.1| thioredoxin reductase 1, cytoplasmic isoform...   464   e-128
ref|NP_056577.2| thioredoxin reductase 1, cytoplasmic isoform 2 ...   464   e-128
gb|AAI67349.1| MGC147163 protein [Xenopus (Silurana) tropicalis]      464   e-128
ref|NP_001116145.1| thioredoxin reductase 1, cytoplasmic [Canis ...   462   e-128
ref|NP_001087660.1| thioredoxin reductase 3 [Xenopus laevis] >gi...   462   e-128
emb|CAH92925.2| thioredoxin reductase [Pongo abelii]                  462   e-128
emb|CBN80599.1| Thioredoxin reductase 3 [Dicentrarchus labrax]        462   e-128
gb|EFN85970.1| Thioredoxin reductase 1, mitochondrial [Harpegnat...   462   e-128
ref|XP_002915522.1| PREDICTED: thioredoxin reductase 1, cytoplas...   462   e-128
ref|XP_516719.2| PREDICTED: thioredoxin reductase 3 [Pan troglod...   461   e-128
gb|AAH30028.1| TXNRD3 protein [Homo sapiens]                          461   e-127
ref|XP_002923145.1| PREDICTED: thioredoxin reductase 3-like [Ail...   461   e-127
gb|EFB23450.1| hypothetical protein PANDA_012236 [Ailuropoda mel...   461   e-127
gb|AAF32362.1|AF220760_1 thioredoxin reductase 1 [Rattus norvegi...   461   e-127
gb|AAD43039.1|AF108213_1 NADPH-dependent thioredoxin reductase [...   461   e-127
sp|Q86VQ6|TRXR3_HUMAN RecName: Full=Thioredoxin reductase 3; Alt...   460   e-127
ref|NP_443115.1| thioredoxin reductase 3 isoform 1 [Homo sapiens]     460   e-127
sp|O89049|TRXR1_RAT RecName: Full=Thioredoxin reductase 1, cytop...   460   e-127
gb|AAH50032.1| TXNRD3 protein [Homo sapiens]                          460   e-127
gb|AAD51325.1|AF171055_1 thioredoxin reductase TR2 [Homo sapiens]     460   e-127
ref|XP_002938124.1| PREDICTED: thioredoxin reductase 1, cytoplas...   459   e-127
ref|NP_001116249.1| thioredoxin reductase 3 [Gallus gallus]           459   e-127
ref|NP_001116250.1| thioredoxin reductase 3 [Canis lupus familia...   459   e-127
gb|AAD39929.1|AF133519_1 thioredoxin reductase 3 [Homo sapiens]       457   e-126
ref|XP_001492801.1| PREDICTED: similar to thioredoxin reductase ...   456   e-126
gb|EFW43678.1| thioredoxin reductase 3 [Capsaspora owczarzaki AT...   456   e-126
emb|CBK24910.2| unnamed protein product [Blastocystis hominis] >...   456   e-126
ref|NP_001171641.1| thioredoxin reductase 3 isoform 1 [Rattus no...   456   e-126
ref|NP_001100079.2| thioredoxin reductase 3 isoform 2 [Rattus no...   456   e-126
ref|XP_002596165.1| hypothetical protein BRAFLDRAFT_203192 [Bran...   456   e-126
ref|XP_002108982.1| hypothetical protein TRIADDRAFT_19325 [Trich...   456   e-126
ref|XP_001377333.1| PREDICTED: similar to TXNRD3 protein [Monode...   455   e-126
ref|NP_001116163.1| thioredoxin reductase 2, mitochondrial [Gall...   454   e-125
ref|XP_797733.2| PREDICTED: hypothetical protein [Strongylocentr...   454   e-125
ref|NP_001171529.1| thioredoxin reductase 3 isoform 1 [Mus muscu...   454   e-125
ref|XP_002713123.1| PREDICTED: Thioredoxin reductase 3-like, par...   454   e-125
sp|Q99MD6|TRXR3_MOUSE RecName: Full=Thioredoxin reductase 3; Alt...   454   e-125
ref|NP_694802.2| thioredoxin reductase 3 isoform 2 [Mus musculus...   454   e-125
dbj|BAB28419.1| unnamed protein product [Mus musculus] >gi|26348...   454   e-125
ref|XP_001991610.1| GH12753 [Drosophila grimshawi] >gi|193901368...   454   e-125
ref|XP_002288115.1| thioredoxin reductase [Thalassiosira pseudon...   453   e-125
ref|XP_002594765.1| hypothetical protein BRAFLDRAFT_122807 [Bran...   452   e-125
ref|XP_002056889.1| GJ16646 [Drosophila virilis] >gi|194146656|g...   452   e-125
gb|AAD25167.1|AF044212_1 thioredoxin reductase [Homo sapiens]         452   e-125
ref|NP_006431.2| thioredoxin reductase 2, mitochondrial precurso...   452   e-125
gb|AAD19597.1| thioredoxin reductase [Homo sapiens]                   452   e-125
ref|XP_850181.1| PREDICTED: similar to thioredoxin reductase 2 i...   452   e-125
gb|EFB13457.1| hypothetical protein PANDA_003518 [Ailuropoda mel...   451   e-125
gb|ADH94550.1| thioredoxin reductase 1 [Apis cerana cerana] >gi|...   451   e-124
gb|AAI17355.1| TXNRD2 protein [Homo sapiens] >gi|313883426|gb|AD...   451   e-124
dbj|BAA77601.2| thioredoxin reductase II alpha [Homo sapiens]         451   e-124
dbj|BAA77602.2| thioredoxin reductase II beta [Homo sapiens]          451   e-124
ref|NP_001120487.1| thioredoxin reductase 2 [Xenopus (Silurana) ...   451   e-124
dbj|BAD92961.1| thioredoxin reductase 2 isoform 1 precursor vari...   451   e-124
gb|AAG47635.1|AF201385_1 mitochondrial thioredoxin reductase [Ho...   451   e-124
ref|XP_001354460.2| GA15270 [Drosophila pseudoobscura pseudoobsc...   449   e-124
ref|XP_002071893.1| GK24920 [Drosophila willistoni] >gi|19416797...   449   e-124
gb|AAH07489.3| TXNRD2 protein [Homo sapiens]                          449   e-124
emb|CBY19735.1| unnamed protein product [Oikopleura dioica]           449   e-124
ref|NP_001152971.1| thioredoxin reductase 2 precursor [Macaca mu...   449   e-124
ref|NP_001171496.1| thioredoxin reductase 1 isoform 1 [Apis mell...   448   e-124
gb|AAP93583.1| thioredoxin reductase [Apis mellifera ligustica]       448   e-124
ref|NP_001171497.1| thioredoxin reductase 1 isoform 2 [Apis mell...   448   e-124
gb|EFN67124.1| Thioredoxin reductase 1, mitochondrial [Camponotu...   448   e-123
ref|XP_002830900.1| PREDICTED: thioredoxin reductase 2, mitochon...   447   e-123
ref|XP_001966148.1| GF19373 [Drosophila ananassae] >gi|190623033...   447   e-123
ref|XP_975772.1| PREDICTED: similar to thioredoxin reductase iso...   446   e-123
pdb|3DGZ|A Chain A, Crystal Structure Of Mouse Mitochondrial Thi...   446   e-123
gb|EDK97524.1| thioredoxin reductase 2, isoform CRA_a [Mus muscu...   446   e-123
sp|Q9JLT4|TRXR2_MOUSE RecName: Full=Thioredoxin reductase 2, mit...   446   e-123
gb|AAF03359.1|AF136399_1 thioredoxin reductase [Mus musculus]         446   e-123
ref|NP_038739.2| thioredoxin reductase 2, mitochondrial precurso...   446   e-123
pdb|1ZDL|A Chain A, Crystal Structure Of Mouse Thioredoxin Reduc...   446   e-123
dbj|BAA86986.2| thioredoxin reductase 2 [Mus musculus]                446   e-123
ref|XP_002920642.1| PREDICTED: thioredoxin reductase 2, mitochon...   445   e-123
ref|XP_002101164.1| GE15773 [Drosophila yakuba] >gi|194188688|gb...   445   e-123
ref|NP_001162173.1| thioredoxin reductase 2, mitochondrial [Sus ...   444   e-122
ref|XP_001455671.1| hypothetical protein [Paramecium tetraurelia...   444   e-122
gb|AAW25951.1| SJCHGC06622 protein [Schistosoma japonicum]            444   e-122
ref|XP_002734086.1| PREDICTED: thioredoxin reductase 1-like [Sac...   444   e-122
ref|NP_001080052.1| thioredoxin reductase 2 [Xenopus laevis]          444   e-122
gb|AAH56136.1| Txnrd2 protein [Xenopus laevis]                        444   e-122
gb|EFZ12491.1| hypothetical protein SINV_11881 [Solenopsis invicta]   444   e-122
pdb|2X8C|A Chain A, Thioredoxin Glutathione Reductase From Schis...   444   e-122
pdb|3H4K|A Chain A, Crystal Structure Of The Wild Type Thioredox...   444   e-122
pdb|2V6O|A Chain A, Structure Of Schistosoma Mansoni Thioredoxin...   444   e-122
ref|XP_001425944.1| hypothetical protein [Paramecium tetraurelia...   444   e-122
gb|AAK85233.1|AF395822_1 thioredoxin glutathione reductase [Schi...   444   e-122
ref|XP_002010389.1| GI15898 [Drosophila mojavensis] >gi|19390883...   443   e-122
emb|CAF96941.1| unnamed protein product [Tetraodon nigroviridis]      443   e-122
sp|B9A1H3|TRXR1_EMIHU RecName: Full=Thioredoxin reductase SEP1; ...   443   e-122
ref|XP_001847793.1| thioredoxin reductase 1, mitochondrial [Cule...   443   e-122
ref|XP_001662666.1| thioredoxin reductase [Aedes aegypti] >gi|10...   443   e-122
ref|XP_001662665.1| thioredoxin reductase [Aedes aegypti] >gi|10...   443   e-122
gb|AAC69637.1| glutathione reductase family member [Musca domest...   442   e-122
gb|ADD18525.1| thioredoxin reductase-1 [Glossina morsitans morsi...   441   e-122
ref|XP_002722800.1| PREDICTED: thioredoxin reductase 2-like [Ory...   441   e-121
ref|XP_001977919.1| GG19308 [Drosophila erecta] >gi|190649568|gb...   441   e-121
gb|ACH86016.1| thioredoxin glutathione reductase [Schistosoma ja...   440   e-121
pdb|3DH9|A Chain A, Crystal Structure Of Drosophila Thioredoxin ...   440   e-121
pdb|3DGH|A Chain A, Crystal Structure Of Drosophila Thioredoxin ...   440   e-121
ref|XP_001603220.1| PREDICTED: similar to thioredoxin reductase ...   440   e-121
pdb|2NVK|X Chain X, Crystal Structure Of Thioredoxin Reductase F...   440   e-121
gb|AAG25640.1|AF301145_1 thioredoxin reductase-1 splice variant ...   440   e-121
ref|NP_727251.1| thioredoxin reductase-1, isoform B [Drosophila ...   440   e-121
ref|NP_511082.2| thioredoxin reductase-1, isoform A [Drosophila ...   440   e-121
ref|NP_727252.1| thioredoxin reductase-1, isoform C [Drosophila ...   440   e-121
ref|XP_002697197.1| PREDICTED: thioredoxin reductase 3 [Bos taur...   439   e-121
ref|NP_001179038.1| thioredoxin reductase 3 [Bos taurus]              439   e-121
gb|EDL77943.1| thioredoxin reductase 2, isoform CRA_a [Rattus no...   439   e-121
ref|NP_072106.1| thioredoxin reductase 2, mitochondrial precurso...   439   e-121
ref|XP_001630291.1| predicted protein [Nematostella vectensis] >...   438   e-121
ref|NP_777051.1| thioredoxin reductase 2, mitochondrial precurso...   438   e-120
ref|XP_002948663.1| NADPH-dependent thioredoxin reductase 1 [Vol...   437   e-120
ref|XP_001488273.1| PREDICTED: similar to TXNRD2 protein [Equus ...   437   e-120
gb|EFX87625.1| hypothetical protein DAPPUDRAFT_306444 [Daphnia p...   437   e-120
gb|EFR25272.1| hypothetical protein AND_09546 [Anopheles darlingi]    435   e-120
ref|XP_002115731.1| hypothetical protein TRIADDRAFT_50766 [Trich...   433   e-119
gb|ACL81231.1| thioredoxin reductase 2 [Moneuplotes crassus]          431   e-118
gb|ACL81230.1| thioredoxin reductase 1 [Moneuplotes crassus]          431   e-118
ref|XP_001696072.1| NADPH-dependent thioredoxin reductase 1 [Chl...   431   e-118
ref|XP_514983.2| PREDICTED: thioredoxin reductase 2 isoform 4 [P...   431   e-118
ref|XP_001166615.1| PREDICTED: similar to mitochondrial thioredo...   431   e-118
gb|EEZ99907.1| hypothetical protein TcasGA2_TC002698 [Tribolium ...   430   e-118
ref|XP_001014761.2| thioredoxin and glutathione reductase family...   430   e-118
ref|XP_310514.3| thioredoxin reductase (AGAP000565-PB) [Anophele...   426   e-117
emb|CAD30858.1| thioredoxin reductase [Anopheles gambiae]             426   e-117
ref|XP_001237264.1| AGAP000565-PA [Anopheles gambiae str. PEST] ...   426   e-117
emb|CAM96615.1| thioredoxin-glutathione reductase [Fasciola hepa...   425   e-117
ref|XP_001942650.1| PREDICTED: similar to thioredoxin reductase ...   425   e-117
ref|XP_002009206.1| GI11388 [Drosophila mojavensis] >gi|19392081...   424   e-116
gb|EGB07743.1| selenoprotein [Aureococcus anophagefferens]            424   e-116
ref|XP_002674924.1| thioredoxin reductase [Naegleria gruberi] >g...   423   e-116
ref|NP_001177260.1| thioredoxin reductase 3 [Ciona intestinalis]      423   e-116
ref|XP_002047939.1| GJ11643 [Drosophila virilis] >gi|194155097|g...   422   e-116
emb|CBJ26963.1| Electron donor (NADH / NADPH)-dependent reductas...   422   e-116
dbj|BAH11490.1| unnamed protein product [Homo sapiens]                422   e-116
gb|EFV61343.1| thioredoxin reductase 1, cytoplasmic [Trichinella...   421   e-115
gb|AAN32903.1| thioredoxin reductase TR1 [Chlamydomonas reinhard...   421   e-115
ref|XP_002154390.1| PREDICTED: similar to MGC81848 protein [Hydr...   421   e-115
ref|XP_002028236.1| GL23230 [Drosophila persimilis] >gi|19411735...   421   e-115
ref|XP_001352389.2| GA10979 [Drosophila pseudoobscura pseudoobsc...   421   e-115
dbj|BAH12374.1| unnamed protein product [Homo sapiens]                420   e-115
gb|AAN63052.1| thioredoxin glutathione reductase [Echinococcus g...   420   e-115
gb|AAN63051.1| thioredoxin glutathione reductase [Echinococcus g...   420   e-115
dbj|BAE72986.1| hypothetical protein [Macaca fascicularis]            419   e-115
ref|XP_002423998.1| thioredoxin reductase, putative [Pediculus h...   419   e-115
dbj|BAE28994.1| unnamed protein product [Mus musculus]                416   e-114
ref|XP_002773322.1| thioredoxin reductase 1, cytoplasmic, putati...   416   e-114
ref|XP_001958552.1| GF23459 [Drosophila ananassae] >gi|190625834...   416   e-114
ref|XP_001973742.1| GG16263 [Drosophila erecta] >gi|190655525|gb...   415   e-114
gb|EAX03014.1| hCG17888, isoform CRA_b [Homo sapiens]                 414   e-113
gb|EAX03013.1| hCG17888, isoform CRA_a [Homo sapiens]                 414   e-113
gb|DAA20379.1| thioredoxin reductase 2, mitochondrial precursor ...   412   e-113
ref|XP_002086704.1| GE23284 [Drosophila yakuba] >gi|194186494|gb...   412   e-113
ref|NP_524216.1| thioredoxin reductase 2 [Drosophila melanogaste...   412   e-113
ref|XP_002040924.1| GM22453 [Drosophila sechellia] >gi|194122434...   412   e-113
gb|EAW79356.1| hCG40656, isoform CRA_b [Homo sapiens]                 412   e-113
ref|XP_003074475.1| thioredoxin reductase TR1 (ISS) [Ostreococcu...   411   e-112
gb|ADL62852.1| thioredoxin reductase 1 [Haemonchus contortus]         410   e-112
emb|CBN76987.1| Thioredoxin reductase [Ectocarpus siliculosus]        410   e-112
gb|EFB29376.1| hypothetical protein PANDA_009396 [Ailuropoda mel...   409   e-112
ref|XP_001984837.1| GH16699 [Drosophila grimshawi] >gi|193898319...   409   e-112
gb|ADY41259.1| Thioredoxin reductase 1 [Ascaris suum]                 406   e-111
ref|XP_001459173.1| hypothetical protein [Paramecium tetraurelia...   406   e-111
ref|XP_002428198.1| thioredoxin reductase, putative [Pediculus h...   404   e-110
ref|XP_003056182.1| thioredoxin-disufide reductase [Micromonas p...   404   e-110
ref|XP_003093270.1| CRE-TRXR-1 protein [Caenorhabditis remanei] ...   403   e-110
ref|XP_001415584.1| thioredoxin reductase, putative selenoenzyme...   403   e-110
ref|NP_001166984.1| thioredoxin reductase 3 isoform 2 [Homo sapi...   400   e-109
ref|XP_001427531.1| hypothetical protein [Paramecium tetraurelia...   400   e-109
ref|XP_969619.1| PREDICTED: similar to thioredoxin reductase [Tr...   399   e-109
gb|AAD46625.1| thioredoxin reductase homolog [Caenorhabditis ele...   399   e-109
ref|NP_501085.2| ThioRedoXin Reductase family member (trxr-1) [C...   399   e-109
ref|XP_002633065.1| C. briggsae CBR-TRXR-1 protein [Caenorhabdit...   399   e-109
ref|XP_001452173.1| hypothetical protein [Paramecium tetraurelia...   396   e-108
gb|EAX03015.1| hCG17888, isoform CRA_c [Homo sapiens]                 395   e-108
ref|XP_001898729.1| Thioredoxin reductase [Brugia malayi] >gi|15...   394   e-107
ref|XP_001166546.1| PREDICTED: thioredoxin reductase 2 isoform 2...   394   e-107
gb|EDK97526.1| thioredoxin reductase 2, isoform CRA_c [Mus muscu...   393   e-107
gb|AAQ03230.1|AF412308_1 mitochondrial thioredoxin reductase 2 [...   393   e-107
ref|XP_002258509.1| thioredoxin reductase 2 [Plasmodium knowlesi...   392   e-107
dbj|BAG53517.1| unnamed protein product [Homo sapiens]                391   e-106
ref|XP_002085912.1| GD15034 [Drosophila simulans] >gi|194197921|...   388   e-106
ref|XP_001614770.1| thioredoxin reductase 2 [Plasmodium vivax Sa...   387   e-105
ref|XP_002808951.1| thioredoxin reductase [Plasmodium falciparum...   386   e-105
ref|XP_001011080.1| thioredoxin and glutathione reductase family...   386   e-105
sp|Q25861|TRXR_PLAF5 RecName: Full=Thioredoxin reductase; Short=...   386   e-105
ref|XP_666572.1| thioredoxin reductase [Cryptosporidium hominis ...   385   e-105
dbj|BAJ77264.1| cgd2_4320 [Cryptosporidium parvum] >gi|323510267...   385   e-104
gb|AAN05789.1| putative thioredoxin reductase [Cryptosporidium p...   385   e-104
ref|XP_626611.1| thioredoxin reductase 1 [Cryptosporidium parvum...   385   e-104
ref|XP_003137903.1| thioredoxin reductase [Loa loa] >gi|30776693...   384   e-104
emb|CAG09709.1| unnamed protein product [Tetraodon nigroviridis]      383   e-104
ref|XP_745009.1| Thioredoxin reductase [Plasmodium chabaudi chab...   383   e-104
ref|XP_001519650.1| PREDICTED: hypothetical protein, partial [Or...   382   e-104
gb|ACV31866.1| thioredoxin reductase [Cryptosporidium parvum]         382   e-104
ref|XP_730274.1| thioredoxin reductase [Plasmodium yoelii yoelii...   379   e-103
ref|XP_002142781.1| thioredoxin reductase [Cryptosporidium muris...   377   e-102
ref|XP_002680287.1| predicted protein [Naegleria gruberi] >gi|28...   376   e-102
ref|XP_002404402.1| thioredoxin reductase, putative [Ixodes scap...   376   e-102
ref|XP_001460198.1| hypothetical protein [Paramecium tetraurelia...   375   e-102
ref|XP_679935.1| Thioredoxin reductase [Plasmodium berghei strai...   375   e-102
ref|XP_001453518.1| hypothetical protein [Paramecium tetraurelia...   375   e-101
gb|ADY44068.1| Glutathione reductase 2 [Ascaris suum]                 374   e-101
emb|CBZ54959.1| MGC84926 protein, related [Neospora caninum Live...   374   e-101
emb|CAA58583.1| thioredoxin reductase [Plasmodium falciparum]         373   e-101
ref|XP_001031841.1| thioredoxin and glutathione reductase family...   372   e-101
gb|EEE25525.1| thioredoxin reductase, putative [Toxoplasma gondi...   370   e-100
ref|XP_002364220.1| thioredoxin reductase, putative [Toxoplasma ...   369   e-100
gb|ADL62853.1| thioredoxin reductase 2 [Haemonchus contortus]         366   4e-99
ref|XP_001031449.2| Pyridine nucleotide-disulphide oxidoreductas...   366   5e-99
emb|CBK22083.2| unnamed protein product [Blastocystis hominis]        365   9e-99
ref|XP_001027232.1| thioredoxin and glutathione reductase family...   363   2e-98
ref|XP_002062260.1| GK16764 [Drosophila willistoni] >gi|19415834...   363   3e-98
ref|XP_003098207.1| CRE-TRXR-2 protein [Caenorhabditis remanei] ...   358   8e-97
ref|XP_001638616.1| predicted protein [Nematostella vectensis] >...   358   1e-96
dbj|BAG61457.1| unnamed protein product [Homo sapiens]                352   6e-95
ref|XP_001432974.1| hypothetical protein [Paramecium tetraurelia...   352   6e-95
ref|NP_498971.1| ThioRedoXin Reductase family member (trxr-2) [C...   352   1e-94
gb|EDL91334.1| thioredoxin reductase 3 (predicted) [Rattus norve...   349   6e-94
ref|XP_001608869.1| thiodoxin reductase [Babesia bovis T2Bo] >gi...   347   2e-93
gb|EAX03016.1| hCG17888, isoform CRA_d [Homo sapiens]                 347   2e-93
gb|AAF21432.1|AF166127_1 selenoprotein Zf2 [Homo sapiens]             347   2e-93
ref|XP_002642468.1| C. briggsae CBR-TRXR-2 protein [Caenorhabdit...   339   7e-91
ref|XP_002765367.1| Thioredoxin reductase, putative [Perkinsus m...   335   1e-89
ref|XP_001032862.1| Pyridine nucleotide-disulphide oxidoreductas...   332   8e-89
gb|AAK93067.1| GM14215p [Drosophila melanogaster]                     322   1e-85
ref|XP_954814.1| thioredoxin reductase [Theileria annulata strai...   320   2e-85
ref|XP_001362937.1| PREDICTED: similar to extracellular reelin [...   311   1e-82
ref|XP_763128.1| thioredoxin reductase [Theileria parva strain M...   311   1e-82
gb|AAL27545.1| thioredoxin reductase 1 [Mus musculus]                 308   1e-81
ref|XP_001440369.1| hypothetical protein [Paramecium tetraurelia...   306   6e-81
gb|AAT85828.1| putative thioredoxin reductase [Glossina morsitan...   301   2e-79
ref|XP_002743594.1| PREDICTED: hypothetical protein LOC100413738...   292   9e-77
gb|EAW79355.1| hCG40656, isoform CRA_a [Homo sapiens]                 290   3e-76
ref|NP_001072534.1| thioredoxin reductase 3 [Xenopus (Silurana) ...   289   6e-76
dbj|BAB27905.1| unnamed protein product [Mus musculus]                283   4e-74
gb|ADY41842.1| Thioredoxin reductase 1 [Ascaris suum]                 278   1e-72
gb|AAH13688.1| Txnrd2 protein [Mus musculus]                          271   2e-70
emb|CAF29507.1| hypothetical protein [Homo sapiens] >gi|51476567...   270   4e-70
gb|AAH99923.1| TXNRD2 protein [Homo sapiens]                          269   6e-70
ref|XP_001166507.1| PREDICTED: hypothetical protein isoform 1 [P...   269   8e-70
emb|CAH65367.1| hypothetical protein RCJMB04_23a5 [Gallus gallus]     266   4e-69
gb|AAO65266.1| thioredoxin reductase TrxR1 [Danio rerio]              266   5e-69
ref|ZP_01629769.1| glutathione reductase [Nodularia spumigena CC...   263   6e-68
ref|XP_001338711.3| PREDICTED: im:7135991 [Danio rerio]               262   8e-68
ref|ZP_01166092.1| glutathione reductase [Oceanospirillum sp. ME...   257   3e-66
ref|NP_191026.1| GR (GLUTATHIONE REDUCTASE); ATP binding / gluta...   257   3e-66
gb|EDK97525.1| thioredoxin reductase 2, isoform CRA_b [Mus muscu...   256   4e-66
gb|AAK27157.1|AF349449_1 glutathione reductase [Brassica juncea]      256   6e-66
ref|XP_002877994.1| hypothetical protein ARALYDRAFT_485870 [Arab...   256   7e-66
ref|YP_001517987.1| glutathione reductase [Acaryochloris marina ...   256   7e-66
ref|ZP_05037269.1| FAD dependent oxidoreductase, putative [Synec...   255   1e-65
gb|AAK96868.1| Gluthatione reductase, chloroplast precursor [Ara...   255   1e-65
ref|ZP_01623681.1| glutathione reductase [Lyngbya sp. PCC 8106] ...   254   2e-65
ref|YP_724176.1| glutathione reductase [Trichodesmium erythraeum...   254   2e-65
gb|EFU02952.1| glutathione-disulfide reductase [Enterococcus fae...   254   3e-65
ref|ZP_07888841.1| glutathione-disulfide reductase [Aggregatibac...   253   4e-65
dbj|BAD27394.1| glutathione reductase [Zinnia violacea]               253   4e-65
gb|ABZ10803.2| chloroplast glutathione reductase [Solanum lycope...   253   5e-65
ref|ZP_05560283.1| glutathione reductase [Enterococcus faecalis ...   253   5e-65
ref|YP_001227458.1| glutathione reductase [Synechococcus sp. RCC...   253   6e-65
ref|ZP_05619657.1| glutathione-disulfide reductase [Enhydrobacte...   252   8e-65
emb|CAN66042.1| hypothetical protein VITISV_014813 [Vitis vinifera]   252   8e-65
gb|AAB70837.1| glutathione reductase (NADPH) [Vitis vinifera]         252   1e-64
gb|EFU16864.1| glutathione-disulfide reductase [Enterococcus fae...   251   1e-64
gb|EFT94888.1| glutathione-disulfide reductase [Enterococcus fae...   251   1e-64
ref|ZP_05574684.1| glutathione reductase [Enterococcus faecalis ...   251   1e-64
ref|XP_002281935.1| PREDICTED: hypothetical protein [Vitis vinif...   251   1e-64
ref|NP_816867.1| glutathione reductase [Enterococcus faecalis V5...   251   1e-64
ref|YP_003885253.1| glutathione oxidoreductase [Dickeya dadantii...   251   2e-64
ref|ZP_05474836.1| glutathione reductase [Enterococcus faecalis ...   251   2e-64
gb|AAD28177.1|AF109694_1 glutathione reductase [Brassica juncea]      251   2e-64
ref|YP_003714407.1| glutathione oxidoreductase, nucleotide-bindi...   251   2e-64
ref|ZP_05577442.1| glutathione reductase [Enterococcus faecalis ...   251   2e-64
ref|YP_002985654.1| glutathione-disulfide reductase [Dickeya dad...   251   2e-64
ref|ZP_05585844.1| glutathione reductase [Enterococcus faecalis ...   250   3e-64
ref|ZP_07564061.1| glutathione-disulfide reductase [Enterococcus...   250   4e-64
ref|ZP_04436622.1| glutathione reductase [Enterococcus faecalis ...   250   4e-64
ref|YP_001352656.1| glutathione reductase [Janthinobacterium sp....   250   4e-64
ref|XP_002294541.1| glutathione reductase, gro-2 [Thalassiosira ...   249   5e-64
ref|XP_001769571.1| predicted protein [Physcomitrella patens sub...   249   7e-64
sp|P80461|GSHRP_TOBAC RecName: Full=Glutathione reductase, chlor...   249   7e-64
ref|YP_001345305.1| glutathione reductase [Actinobacillus succin...   249   7e-64
ref|ZP_05025849.1| glutathione-disulfide reductase [Microcoleus ...   249   9e-64
ref|YP_001563379.1| glutathione-disulfide reductase [Delftia aci...   249   9e-64
ref|YP_001617210.1| glutathione-disulfide reductase [Sorangium c...   248   1e-63
ref|YP_390410.1| glutathione reductase [Thiomicrospira crunogena...   248   1e-63
ref|YP_003776700.1| glutathione reductase [Herbaspirillum serope...   248   2e-63
ref|ZP_02156112.1| glutathione reductase [Shewanella benthica KT...   247   3e-63
ref|ZP_04627945.1| Glutathione reductase [Yersinia bercovieri AT...   247   3e-63
ref|YP_001412373.1| glutathione-disulfide reductase [Parvibaculu...   247   3e-63
ref|YP_663759.1| glutathione-disulfide reductase [Pseudoalteromo...   247   3e-63
ref|ZP_08066809.1| glutathione-disulfide reductase [Actinobacill...   246   4e-63
ref|ZP_07895395.1| glutathione-disulfide reductase [Enterococcus...   246   4e-63
emb|CBW15027.1| glutathione oxidoreductase [Haemophilus parainfl...   246   4e-63
ref|YP_002475911.1| glutathione reductase [Haemophilus parasuis ...   246   4e-63
gb|ABF29525.1| dual-targeted glutathione reductase [Phaseolus vu...   246   4e-63
ref|YP_072299.1| glutathione reductase [Yersinia pseudotuberculo...   246   4e-63
ref|ZP_04631501.1| Glutathione reductase [Yersinia frederiksenii...   246   4e-63
ref|ZP_08149145.1| glutathione-disulfide reductase [Haemophilus ...   245   1e-62
ref|YP_002152536.1| glutathione reductase [Proteus mirabilis HI4...   245   1e-62
ref|YP_003331617.1| glutathione-disulfide reductase [Dickeya dad...   245   1e-62
ref|YP_003002387.1| glutathione reductase [Dickeya zeae Ech1591]...   245   1e-62
ref|YP_002379567.1| glutathione reductase [Cyanothece sp. PCC 74...   245   1e-62
ref|XP_001754283.1| predicted protein [Physcomitrella patens sub...   245   1e-62
ref|ZP_01792982.1| glutathione reductase [Haemophilus influenzae...   245   1e-62
ref|ZP_01078137.1| glutathione reductase [Marinomonas sp. MED121...   245   1e-62
ref|ZP_04636901.1| Glutathione reductase [Yersinia intermedia AT...   245   1e-62
ref|XP_002520986.1| glutathione reductase, putative [Ricinus com...   244   2e-62
ref|YP_001718880.1| glutathione reductase [Yersinia pseudotuberc...   244   2e-62
ref|YP_247881.1| glutathione reductase [Haemophilus influenzae 8...   244   2e-62
ref|XP_003194185.1| glutathione-disulfide reductase [Cryptococcu...   244   2e-62
ref|YP_001659640.1| glutathione reductase [Microcystis aeruginos...   244   2e-62
ref|YP_003469981.1| glutathione oxidoreductase, nucleotide-bindi...   244   3e-62
ref|ZP_04611707.1| Glutathione reductase [Yersinia rohdei ATCC 4...   244   3e-62
ref|ZP_02479102.1| aminopeptidase B [Haemophilus parasuis 29755]...   244   3e-62
ref|ZP_01797072.1| glutathione reductase [Haemophilus influenzae...   244   3e-62
ref|YP_002924646.1| lipoamide dehydrogenase, E3 component is par...   243   4e-62
ref|ZP_03826978.1| glutathione reductase [Pectobacterium carotov...   243   4e-62
ref|YP_002544745.1| glutathione-disulfide reductase [Agrobacteri...   243   4e-62
ref|YP_001909236.1| glutathione reductase [Erwinia tasmaniensis ...   243   4e-62
ref|YP_002281519.1| glutathione reductase [Rhizobium leguminosar...   243   4e-62
ref|YP_001402993.1| glutathione reductase [Yersinia pseudotuberc...   243   4e-62
ref|YP_001471883.1| glutathione reductase [Shewanella sediminis ...   243   4e-62
ref|ZP_01789317.1| glutathione reductase [Haemophilus influenzae...   243   4e-62
ref|YP_399860.1| glutathione reductase [Synechococcus elongatus ...   243   4e-62
sp|P27456|GSHRP_PEA RecName: Full=Glutathione reductase, chlorop...   243   4e-62
emb|CAA42921.1| glutathione reductase (NADPH) [Pisum sativum]         243   4e-62
ref|YP_004210929.1| glutathione-disulfide reductase [Rahnella sp...   243   5e-62
ref|YP_004136325.1| glutathione oxidoreductase [Haemophilus infl...   243   5e-62
ref|YP_003743693.1| Glutathione reductase [Erwinia billingiae Eb...   243   5e-62
ref|YP_003255074.1| glutathione reductase [Aggregatibacter actin...   243   5e-62
ref|ZP_04640560.1| Glutathione reductase [Yersinia mollaretii AT...   243   5e-62
ref|ZP_03830608.1| glutathione reductase [Pectobacterium carotov...   243   5e-62
emb|CAO91430.1| gor [Microcystis aeruginosa PCC 7806]                 243   5e-62
ref|YP_001290323.1| glutathione reductase [Haemophilus influenza...   243   5e-62
ref|YP_653712.1| glutathione reductase [Yersinia pestis Antiqua]...   243   5e-62
ref|NP_489008.1| glutathione reductase [Nostoc sp. PCC 7120] >gi...   243   5e-62
ref|ZP_01917795.1| glutathione reductase [Yersinia pestis CA88-4...   243   5e-62
gb|ADO95917.1| Glutathione oxidoreductase [Haemophilus influenza...   243   5e-62
ref|NP_671146.1| glutathione reductase [Yersinia pestis KIM 10] ...   243   5e-62
ref|YP_003887325.1| glutathione-disulfide reductase [Cyanothece ...   243   6e-62
ref|YP_003721936.1| glutathione-disulfide reductase ['Nostoc azo...   242   8e-62
ref|YP_003554885.1| glutathione reductase [Shewanella violacea D...   242   8e-62
ref|YP_003008633.1| glutathione reductase [Aggregatibacter aphro...   242   8e-62
ref|ZP_01787054.1| glutathione reductase [Haemophilus influenzae...   242   8e-62
ref|YP_089177.1| glutathione reductase [Mannheimia succiniciprod...   242   8e-62
ref|YP_171408.1| glutathione reductase [Synechococcus elongatus ...   242   8e-62
ref|NP_438331.1| glutathione reductase [Haemophilus influenzae R...   242   8e-62
emb|CBW28405.1| glutathione oxidoreductase [Haemophilus influenz...   242   1e-61
ref|YP_003019736.1| glutathione-disulfide reductase [Pectobacter...   242   1e-61
ref|ZP_07054263.1| glutathione-disulfide reductase [Listeria gra...   242   1e-61
ref|ZP_06126460.2| glutathione-disulfide reductase [Providencia ...   242   1e-61
ref|YP_001652255.1| glutathione reductase [Actinobacillus pleuro...   242   1e-61
ref|YP_001292054.1| glutathione reductase [Haemophilus influenza...   242   1e-61
ref|YP_001280894.1| glutathione reductase [Psychrobacter sp. PRw...   242   1e-61
ref|NP_001048485.1| Os02g0813500 [Oryza sativa Japonica Group] >...   242   1e-61
ref|ZP_01114352.1| glutathione reductase [Reinekea sp. MED297] >...   242   1e-61
ref|XP_775436.1| hypothetical protein CNBE1510 [Cryptococcus neo...   242   1e-61
ref|ZP_00135555.2| COG1249: Pyruvate/2-oxoglutarate dehydrogenas...   242   1e-61
ref|ZP_07952866.1| glutathione-disulfide reductase [Enterobacter...   241   1e-61
emb|CBX82448.1| glutathione oxidoreductase [Erwinia amylovora AT...   241   1e-61
ref|ZP_07528241.1| Glutathione reductase [Actinobacillus pleurop...   241   1e-61
ref|ZP_06192796.1| hypothetical protein SOD_h01970 [Serratia odo...   241   1e-61
ref|ZP_05989915.1| glutathione-disulfide reductase [Mannheimia h...   241   1e-61
ref|ZP_04622224.1| Glutathione reductase [Yersinia kristensenii ...   241   1e-61
ref|ZP_01784260.1| glutathione reductase [Haemophilus influenzae...   241   1e-61
ref|XP_570771.1| glutathione-disulfide reductase [Cryptococcus n...   241   1e-61
ref|YP_453748.1| glutathione reductase [Sodalis glossinidius str...   241   1e-61
ref|ZP_08139743.1| glutathione reductase [Pseudomonas sp. TJI-51...   241   2e-61
ref|YP_002872566.1| glutathione reductase [Pseudomonas fluoresce...   241   2e-61
ref|ZP_05089326.1| glutathione-disulfide reductase [Ruegeria sp....   241   2e-61
ref|ZP_04976741.1| glutathione-disulfide reductase [Mannheimia h...   241   2e-61
ref|ZP_01795383.1| Na(+)-translocating NADH-quinone reductase su...   241   2e-61
ref|YP_003522067.1| Gor [Pantoea ananatis LMG 20103] >gi|2911543...   241   2e-61
ref|XP_002321515.1| glutathione reductase [Populus trichocarpa] ...   241   2e-61
ref|ZP_05076940.1| glutathione-disulfide reductase [Rhodobactera...   241   2e-61
ref|YP_260503.1| glutathione reductase [Pseudomonas fluorescens ...   240   3e-61
gb|ADZ44270.1| glutathione reductase [Yersinia enterocolitica su...   240   4e-61
ref|ZP_07339108.1| glutathione reductase [Actinobacillus pleurop...   240   4e-61
ref|YP_003532896.1| glutathione oxidoreductase [Erwinia amylovor...   240   4e-61
emb|CAY76180.1| glutathione oxidoreductase [Erwinia pyrifoliae D...   240   4e-61
ref|YP_003212379.1| glutathione reductase [Cronobacter turicensi...   240   4e-61
ref|ZP_04752888.1| glutathione reductase [Actinobacillus minor N...   240   4e-61
ref|YP_002650515.1| glutathione reductase [Erwinia pyrifoliae Ep...   240   4e-61
gb|ABB88584.1| glutathione reductase [Ulva fasciata]                  240   4e-61
ref|ZP_00960040.1| glutathione-disulfide reductase [Roseovarius ...   240   4e-61
gb|ADI80343.1| glutathione reductase [Chlamydomonas sp. ICE-L]        239   5e-61
ref|YP_002236123.1| glutathione-disulfide reductase [Klebsiella ...   239   5e-61
ref|YP_001008198.1| glutathione reductase [Yersinia enterocoliti...   239   5e-61
ref|NP_745949.1| glutathione reductase [Pseudomonas putida KT244...   239   5e-61
sp|P48640|GSHRP_SOYBN RecName: Full=Glutathione reductase, chlor...   239   5e-61
ref|YP_958634.1| pyridine nucleotide-disulphide oxidoreductase d...   239   5e-61
emb|CBY29391.1| glutathione reductase [Yersinia enterocolitica s...   239   7e-61
ref|YP_003932656.1| glutathione oxidoreductase [Pantoea vagans C...   239   7e-61
ref|ZP_06635312.1| aminopeptidase B [Aggregatibacter actinomycet...   239   7e-61
ref|ZP_05650808.1| glutathione reductase [Enterococcus gallinaru...   239   7e-61
gb|AAF26175.1|AF105199_1 glutathione reductase [Glycine max]          239   7e-61
ref|YP_001095785.1| glutathione reductase [Shewanella loihica PV...   239   7e-61
gb|ADR59608.1| Glutathione reductase [Pseudomonas putida BIRD-1]      239   9e-61
ref|YP_003437178.1| glutathione-disulfide reductase [Klebsiella ...   239   9e-61
ref|ZP_04618576.1| Glutathione reductase [Yersinia aldovae ATCC ...   239   9e-61
ref|YP_001440238.1| glutathione reductase [Cronobacter sakazakii...   239   9e-61
ref|YP_001758517.1| glutathione reductase [Shewanella woodyi ATC...   239   9e-61
ref|YP_768279.1| glutathione reductase [Rhizobium leguminosarum ...   239   9e-61
ref|YP_322757.1| glutathione reductase [Anabaena variabilis ATCC...   239   9e-61
emb|CAA61856.1| glutathione reductase (NADPH) [Nostoc sp. PCC 7120]   239   9e-61
ref|YP_743364.1| NADPH-glutathione reductase [Alkalilimnicola eh...   239   9e-61
ref|ZP_06637767.1| glutathione-disulfide reductase [Serratia odo...   238   1e-60
ref|ZP_02958557.1| hypothetical protein PROSTU_00303 [Providenci...   238   1e-60
ref|ZP_01731018.1| glutathione reductase [Cyanothece sp. CCY0110...   238   1e-60
ref|YP_048191.1| glutathione reductase [Pectobacterium atrosepti...   238   1e-60
ref|YP_004138455.1| glutathione oxidoreductase [Haemophilus infl...   238   2e-60
ref|YP_527323.1| glutathione reductase [Saccharophagus degradans...   238   2e-60
ref|YP_348659.1| glutathione reductase [Pseudomonas fluorescens ...   238   2e-60
ref|NP_246172.1| glutathione reductase [Pasteurella multocida su...   238   2e-60
ref|ZP_03063396.1| glutathione-disulfide reductase [Shigella dys...   238   2e-60
ref|ZP_06013809.1| glutathione-disulfide reductase [Klebsiella p...   238   2e-60
ref|YP_002921709.1| glutathione reductase [Klebsiella pneumoniae...   238   2e-60
ref|YP_003147724.1| glutathione reductase [Kangiella koreensis D...   238   2e-60
ref|YP_003039130.1| glutathione reductase [Photorhabdus asymbiot...   238   2e-60
ref|YP_001337520.1| glutathione reductase [Klebsiella pneumoniae...   238   2e-60
ref|YP_607911.1| glutathione reductase [Pseudomonas entomophila ...   238   2e-60
ref|YP_166571.1| glutathione-disulfide reductase [Ruegeria pomer...   238   2e-60
ref|NP_417957.1| glutathione oxidoreductase [Escherichia coli st...   238   2e-60
ref|YP_001267277.1| glutathione reductase [Pseudomonas putida F1...   238   2e-60
ref|ZP_06896769.1| glutathione-disulfide reductase [Roseomonas c...   237   3e-60
ref|ZP_06308334.1| Glutathione reductase [Cylindrospermopsis rac...   237   3e-60
ref|NP_927730.1| glutathione reductase [Photorhabdus luminescens...   237   3e-60
ref|YP_001464965.1| glutathione reductase [Escherichia coli E243...   237   3e-60
ref|YP_001460294.1| glutathione reductase [Escherichia coli HS] ...   237   3e-60
ref|ZP_00514499.1| Glutathione reductase, plant [Crocosphaera wa...   237   3e-60
ref|ZP_07775309.1| glutathione reductase (NADPH) [Pseudomonas fl...   237   4e-60
ref|ZP_07620910.1| glutathione reductase [Escherichia coli TA280]     237   4e-60
ref|ZP_06655586.1| glutathione-disulfide reductase [Escherichia ...   237   4e-60
ref|ZP_05919188.1| glutathione-disulfide reductase [Pasteurella ...   237   4e-60
gb|EEE50959.1| hypothetical protein OsJ_31517 [Oryza sativa Japo...   237   4e-60
ref|YP_002384573.1| glutathione reductase [Escherichia fergusoni...   237   4e-60
gb|EEC66940.1| hypothetical protein OsI_33569 [Oryza sativa Indi...   237   4e-60
ref|YP_001750047.1| glutathione reductase [Pseudomonas putida W6...   237   4e-60
ref|YP_001341220.1| pyridine nucleotide-disulfide oxidoreductase...   237   4e-60
gb|EGC96927.1| glutathione reductase [Escherichia fergusonii ECD...   236   5e-60
ref|ZP_07110016.1| glutathione reductase [Oscillatoria sp. PCC 6...   236   5e-60
ref|YP_002399991.1| glutathione reductase [Escherichia coli ED1a...   236   5e-60
ref|YP_001978597.1| glutathione reductase protein [Rhizobium etl...   236   5e-60
ref|ZP_01737440.1| glutathione reductase [Marinobacter sp. ELB17...   236   5e-60
ref|XP_001833633.1| glutathione-disulfide reductase [Coprinopsis...   236   5e-60
ref|NP_709280.1| glutathione reductase [Shigella flexneri 2a str...   236   5e-60
ref|NP_312399.1| glutathione reductase [Escherichia coli O157:H7...   236   5e-60

>ref|XP_002896377.1| thioredoxin reductase 1 [Phytophthora infestans T30-4]
 gb|EEY67612.1| thioredoxin reductase 1 [Phytophthora infestans T30-4]
          Length = 856

 Score =  808 bits (2088), Expect = 0.0
 Identities = 388/467 (83%), Positives = 421/467 (90%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDLVVIGGGSGGLACSKEAASFG+KVCVLDYVKPSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 161 SYDYDLVVIGGGSGGLACSKEAASFGQKVCVLDYVKPSPQGTSWGLGGTCVNVGCIPKKL 220

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQSSLIGE+LHHD ASFGWNV S  G  P FDWKQLV+NV            VELRSK 
Sbjct: 221 MHQSSLIGEVLHHDSASFGWNVSSGQGSAPIFDWKQLVTNVDGYIRGINFKYKVELRSKY 280

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGELAVSSDDIFW 180
           VKYEN LGSF+DPHTL+LWHP+KG+K+ITTR VVIAVGGRPR+L   GGE A+SSDDIFW
Sbjct: 281 VKYENFLGSFIDPHTLELWHPRKGSKQITTRDVVIAVGGRPRELTIPGGEHAISSDDIFW 340

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           MK KEPGKTLVVGASYVALECAGFLKGMGY VKVMVRSILLRGFDQDMA+KIGEYME+QS
Sbjct: 341 MKTKEPGKTLVVGASYVALECAGFLKGMGYDVKVMVRSILLRGFDQDMANKIGEYMEVQS 400

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           GIEFIRKTVPQSITKL++GQLLVKW +EDG+  EE FD+VLNATGRDPD+AKL LD+AGV
Sbjct: 401 GIEFIRKTVPQSITKLENGQLLVKWTSEDGESCEEAFDSVLNATGRDPDIAKLDLDKAGV 460

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVIDAPELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
           KLNEKTGRIWV +EQT+TPN+YAIGDVIDAPELTPVAIQAGRLLSRRLYN  TVQMDYDK
Sbjct: 461 KLNEKTGRIWVKHEQTSTPNIYAIGDVIDAPELTPVAIQAGRLLSRRLYNNATVQMDYDK 520

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           +CTAVFTPIEYGCCGLSEEDS + +G D +EVYH NFVPLEWSL+ +TR AAESCYVKV+
Sbjct: 521 VCTAVFTPIEYGCCGLSEEDSIKRFGKDKIEVYHTNFVPLEWSLSTETRAAAESCYVKVI 580

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CD+ R+ FV+GFHYLGPNAGEVTQAMGLAMKLGFTYDQ+VDTVGIHP
Sbjct: 581 CDRIRDKFVVGFHYLGPNAGEVTQAMGLAMKLGFTYDQMVDTVGIHP 627


>ref|XP_001744219.1| hypothetical protein [Monosiga brevicollis MX1]
 gb|EDQ90922.1| predicted protein [Monosiga brevicollis MX1]
          Length = 506

 Score =  473 bits (1218), Expect = e-131
 Identities = 243/469 (51%), Positives = 321/469 (68%), Gaps = 15/469 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLA SKEAAS G K  VLD+V+PSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 26  FDYDLVVVGGGSGGLAASKEAASLGAKTAVLDFVQPSPQGTTWGLGGTCVNVGCIPKKLM 85

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+++IG  +  D  SFGW++          +W  LV  V            V LR K V
Sbjct: 86  HQAAIIGHTIE-DATSFGWDLQRPEKP----NWSTLVEGVQNHIRSLNWGYRVALRDKNV 140

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  GS +D HT+   + +   + IT   +++  GGRPR     G  E  ++SDDIF 
Sbjct: 141 TYLNAYGSLLDAHTINTVNKRGKEQVITADKIILCPGGRPRYPDIPGAKEFGITSDDIFS 200

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +  +EPGKTLV+GASYVALECAGFL   GY   VMVRSILLRGFD ++A KIG++ME  +
Sbjct: 201 L-DREPGKTLVIGASYVALECAGFLAAFGYDTTVMVRSILLRGFDSEIAQKIGDHMERHA 259

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
            ++F+R+  P  I K + G+L+V + T++G+   + FDTVL A GRD   + +GLD+AGV
Sbjct: 260 HVKFVRQATPDRIEKREDGRLVVHY-TQNGEAVSDEFDTVLFAIGRDACTSTMGLDKAGV 318

Query: 301 KLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDY 358
           +LNE+ G++  N  +QT  PN+YAIGDV++  PELTPVAIQAG+LL+RRLY +    MDY
Sbjct: 319 QLNERNGKVVANEADQTNVPNIYAIGDVLEGKPELTPVAIQAGKLLARRLYGQSAALMDY 378

Query: 359 DKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVK 418
             +CT VFTP+EYGCCG SE+D+ +++G+D +EV+H++F PLEW++  +       C+ K
Sbjct: 379 QNVCTTVFTPLEYGCCGFSEDDALDQFGED-IEVFHQSFTPLEWTVPHRPE---NVCFCK 434

Query: 419 VVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +V  K+ +  VLG H+LGPNAGEVTQ  G+A+KL  T  Q  D VGIHP
Sbjct: 435 LVVQKSTDR-VLGLHFLGPNAGEVTQGFGMALKLKATKAQFDDLVGIHP 482


>ref|XP_002798903.1| PREDICTED: thioredoxin reductase 1, cytoplasmic [Macaca mulatta]
          Length = 596

 Score =  473 bits (1217), Expect = e-131
 Identities = 253/474 (53%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 109 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 169 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 223

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 224 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 283

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMASKIGE+ME +
Sbjct: 284 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMASKIGEHME-E 341

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +V   T   +  E  ++TVL A GRD    K+GL
Sbjct: 342 HGIKFIRQFVPIKIEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGL 401

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 402 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 461

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 462 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 518

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 519 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 572


>ref|NP_001025933.2| thioredoxin reductase 1 [Gallus gallus]
          Length = 499

 Score =  472 bits (1214), Expect = e-131
 Identities = 254/474 (53%), Positives = 320/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL+VIGGGSGGLA +KEAA + KKV VLD+V P+P G SWGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIVIGGGSGGLAAAKEAAKYEKKVMVLDFVTPTPLGNSWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       +    +W  +  +V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRKFGWQFT----EEVKHNWMTMTESVQNYIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G FV PHT+K  + +   K  T    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VTYENAYGEFVGPHTVKATNKRGVEKLYTAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGEYME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQDMANKIGEYME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + +++ G      +    T+D    EE ++TVL A GRD    K+GL
Sbjct: 243 HGIKFIREFVPIKVEQIEEGTPGRLKVTAKSTKDDQVIEEEYNTVLLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           D+ GVK+NEKTG+I V++ EQT  P +YAIGD++ D  ELTPVAIQAGRLL +RLY   T
Sbjct: 303 DKVGVKINEKTGKIPVDDMEQTNVPYIYAIGDILQDRLELTPVAIQAGRLLVQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           ++ DY  + T VFTP+EYG CG SEE++ +++G++++EVYH +F PLEW++  +      
Sbjct: 363 LKCDYVNVPTTVFTPLEYGACGYSEENAIQKFGEENIEVYHSHFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    AMK G T DQL  T+GIHP
Sbjct: 420 KCYAKIICNIQDNQRVIGFHVLGPNAGEVTQGFAAAMKCGLTKDQLDSTIGIHP 473


>ref|NP_001116141.1| thioredoxin reductase 1, cytoplasmic [Pan troglodytes]
          Length = 499

 Score =  471 bits (1213), Expect = e-131
 Identities = 251/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TVL A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>ref|NP_001127133.1| thioredoxin reductase 1, cytoplasmic [Pongo abelii]
 emb|CAI30275.1| hypothetical protein [Pongo abelii]
          Length = 499

 Score =  471 bits (1213), Expect = e-131
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNRIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTL+VGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TVL A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPVKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>sp|Q5NVA2|TRXR1_PONAB RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
          Length = 499

 Score =  471 bits (1212), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTL+VGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TVL A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>gb|AAL15432.1| thioredoxin reductase 1 [Homo sapiens]
          Length = 647

 Score =  471 bits (1212), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 160 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 219

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 220 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 274

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 275 VVYENAYGQFIGPHRIKATNNKGKEKIYSAESFLIATGERPRYLGIPGDKEYCISSDDLF 334

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 335 SLPYC-PGKTLVVGASYVALECAGFLAGIGLGVTVMVRSILLRGFDQDMANKIGEHME-E 392

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 393 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 452

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 453 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 512

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 513 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 569

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 570 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 623


>gb|AAB35418.1| thioredoxin reductase [Homo sapiens]
 emb|CAA62629.1| thioredoxin reductase (NADPH) [Homo sapiens]
          Length = 497

 Score =  471 bits (1212), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAESFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLGVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>ref|NP_777050.1| thioredoxin reductase 1, cytoplasmic [Bos taurus]
 sp|O62768|TRXR1_BOVIN RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
 gb|AAC13914.1| thioredoxin reductase [Bos taurus]
 gb|DAA29739.1| thioredoxin reductase 1 [Bos taurus]
          Length = 499

 Score =  471 bits (1212), Expect = e-130
 Identities = 252/473 (53%), Positives = 320/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA + KKV VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAAKYDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 70

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GWNV     +    DW+++   V            V LR K+V
Sbjct: 71  HQAALLGQALR-DSRNYGWNVE----ETVKHDWERMTEAVQNHIGSLNWGYRVALREKKV 125

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 126 TYENAYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFS 185

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+M+ + 
Sbjct: 186 LPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMQ-EH 243

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           GI+FIR+ VP  + ++++G      ++   T+     E  ++TVL A GRD    K+GL+
Sbjct: 244 GIKFIRQFVPIKVEQIEAGTPGRLRVIAKSTDSDQTIEGEYNTVLLAIGRDACTRKIGLE 303

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTV 354
             GVK+NEKTG+I V   EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   TV
Sbjct: 304 NVGVKINEKTGKIPVTEEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTV 363

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G+++VEVYH  F PLEW++  +       
Sbjct: 364 KCDYENVPTTVFTPLEYGSCGLSEEKAVEKFGEENVEVYHSYFWPLEWTIPSRDN---NK 420

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY KVVC+   N  V+GFH LGPNAGEVTQ    A+K G T DQL  T+GIHP
Sbjct: 421 CYAKVVCNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHP 473


>pdb|2ZZ0|A Chain A, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZ0|B Chain B, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZ0|C Chain C, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZ0|D Chain D, Crystal Structure Of Human Thioredoxin Reductase I (Secys
           498 Cys)
 pdb|2ZZB|A Chain A, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZB|B Chain B, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZB|C Chain C, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZB|D Chain D, Crystal Structure Of Human Thioredoxin Reductase I And
           Terpyridine Platinum(Ii)
 pdb|2ZZC|A Chain A, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
 pdb|2ZZC|B Chain B, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
 pdb|2ZZC|C Chain C, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
 pdb|2ZZC|D Chain D, Crystal Structure Of Nadp(H):human Thioredoxin Reductase I
          Length = 513

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 24  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 83

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 84  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 138

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 139 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 198

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 199 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 256

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 257 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 316

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 317 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 376

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 377 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 433

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 434 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 487


>dbj|BAH11961.1| unnamed protein product [Homo sapiens]
          Length = 547

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 60  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 119

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 120 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 174

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 175 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 234

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 235 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 292

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 293 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 352

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 353 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 412

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 413 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 469

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 470 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 523


>pdb|2J3N|A Chain A, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|B Chain B, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|C Chain C, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|D Chain D, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|E Chain E, X-Ray Structure Of Human Thioredoxin Reductase 1
 pdb|2J3N|F Chain F, X-Ray Structure Of Human Thioredoxin Reductase 1
          Length = 519

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 30  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 89

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 90  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 144

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 145 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 204

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 205 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 262

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 263 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 322

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 323 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 382

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 383 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 439

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 440 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 493


>ref|NP_001087240.1| thioredoxin reductase 1, cytoplasmic isoform 3 [Homo sapiens]
 sp|Q16881|TRXR1_HUMAN RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Gene associated with retinoic and
           interferon-induced mortality 12 protein; Short=GRIM-12;
           Short=Gene associated with retinoic and IFN-induced
           mortality 12 protein; AltName: Full=KM-102-derived
           reductase-like factor; AltName: Full=Thioredoxin
           reductase TR1
          Length = 649

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 160 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 219

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 220 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 274

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 275 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 334

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 335 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 392

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 393 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 452

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 453 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 512

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 513 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 569

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 570 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 623


>ref|NP_003321.3| thioredoxin reductase 1, cytoplasmic isoform 1 [Homo sapiens]
          Length = 551

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 62  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 121

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 122 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 176

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 177 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 236

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 237 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 294

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 295 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 354

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 355 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 414

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 415 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 471

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 472 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 525


>gb|EAW97743.1| thioredoxin reductase 1 [Homo sapiens]
 gb|EAW97744.1| thioredoxin reductase 1 [Homo sapiens]
          Length = 623

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 136 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 195

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 196 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 250

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 251 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 310

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 311 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 368

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 369 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 428

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 429 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 488

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 489 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 545

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 546 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 599


>gb|EAW97745.1| thioredoxin reductase 1 [Homo sapiens]
 dbj|BAH14140.1| unnamed protein product [Homo sapiens]
          Length = 647

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 160 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 219

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 220 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 274

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 275 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 334

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 335 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 392

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 393 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 452

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 453 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 512

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 513 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 569

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 570 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 623


>pdb|2CFY|A Chain A, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|B Chain B, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|C Chain C, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|D Chain D, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|E Chain E, Crystal Structure Of Human Thioredoxin Reductase 1
 pdb|2CFY|F Chain F, Crystal Structure Of Human Thioredoxin Reductase 1
          Length = 521

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 32  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 91

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 92  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 146

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 147 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 206

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 207 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 264

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 265 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 324

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 325 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 384

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 385 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 441

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 442 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 495


>emb|CAA04503.1| thioredoxin reductase [Homo sapiens]
 gb|AAV38446.1| thioredoxin reductase 1 [Homo sapiens]
 gb|AAZ67916.1| thioredoxin reductase 1 [Homo sapiens]
 dbj|BAG35193.1| unnamed protein product [Homo sapiens]
          Length = 497

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>ref|NP_877393.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Homo sapiens]
 ref|NP_877419.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Homo sapiens]
 ref|NP_877420.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Homo sapiens]
 gb|AAH18122.2| Thioredoxin reductase 1 [Homo sapiens]
          Length = 499

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>gb|AAC69621.1| thioredoxin reductase GRIM-12 [Homo sapiens]
          Length = 497

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLNVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>dbj|BAA13674.1| KM-102-derived reductase-like factor [Homo sapiens]
          Length = 549

 Score =  471 bits (1211), Expect = e-130
 Identities = 250/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 62  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 121

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 122 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 176

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 177 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 236

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 237 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 294

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 295 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 354

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 355 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 414

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 415 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 471

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 472 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 525


>ref|NP_001131081.1| thioredoxin reductase 1 [Equus caballus]
          Length = 499

 Score =  470 bits (1210), Expect = e-130
 Identities = 250/474 (52%), Positives = 326/474 (68%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA + KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAKYNKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GWNV     ++   DW+++   V            V LR K+
Sbjct: 70  MHQAALLGQALR-DSRNYGWNVE----EMVKHDWEKMTEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VTYENAYGQFIGPHRIKTTNNKGKEKIYSAEKFLIATGERPRYLDIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDS---GQL-LVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++FI++ VP  + ++++   GQL +V   T+  +  E  ++TVL A GRD    K+GL
Sbjct: 243 HGVKFIKQFVPIKVEQIEAGTPGQLRVVAQSTKGDETIEGEYNTVLLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE++ E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEENAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>pdb|1H6V|A Chain A, Mammalian Thioredoxin Reductase
 pdb|1H6V|B Chain B, Mammalian Thioredoxin Reductase
 pdb|1H6V|C Chain C, Mammalian Thioredoxin Reductase
 pdb|1H6V|D Chain D, Mammalian Thioredoxin Reductase
 pdb|1H6V|E Chain E, Mammalian Thioredoxin Reductase
 pdb|1H6V|F Chain F, Mammalian Thioredoxin Reductase
          Length = 499

 Score =  470 bits (1210), Expect = e-130
 Identities = 250/474 (52%), Positives = 320/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT+WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KV+C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>ref|XP_003126688.1| PREDICTED: thioredoxin reductase 1, cytoplasmic-like [Sus scrofa]
          Length = 497

 Score =  470 bits (1209), Expect = e-130
 Identities = 249/473 (52%), Positives = 320/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA F K+V VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 70

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GWNV     +    DW+++   V            V LR K+V
Sbjct: 71  HQAALLGQALR-DSRNYGWNVE----ETIKHDWERMTEAVQNHIGSLNWGYRVALREKKV 125

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 126 TYENAYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFS 185

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME + 
Sbjct: 186 LPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EH 243

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++FIR+ VP  + ++++G      +    T   +  E  ++TVL A GRD     +GL+
Sbjct: 244 GVKFIRQFVPIKVEQIEAGMPGRLRVTAKATNSDETIEGEYNTVLLAIGRDACTRNIGLE 303

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
             GV++NEKTG+I V + EQT  P VYAIGD+++  PELTPVAIQAGRLL++RLY   TV
Sbjct: 304 TVGVEINEKTGKIPVTDEEQTNVPYVYAIGDILEGKPELTPVAIQAGRLLAQRLYGGSTV 363

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G++++E+YH  F PLEW++  +       
Sbjct: 364 KCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEIYHSYFWPLEWTIPSRDN---NK 420

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K+VC+   N  V+GFH LGPNAGEVTQ    A+K G T DQL  T+GIHP
Sbjct: 421 CYAKIVCNIKDNERVVGFHILGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHP 473


>gb|EDM17072.1| thioredoxin reductase 1, isoform CRA_b [Rattus norvegicus]
 gb|EDM17073.1| thioredoxin reductase 1, isoform CRA_b [Rattus norvegicus]
          Length = 497

 Score =  470 bits (1209), Expect = e-130
 Identities = 251/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KVVC+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>gb|EDM17071.1| thioredoxin reductase 1, isoform CRA_a [Rattus norvegicus]
          Length = 611

 Score =  470 bits (1209), Expect = e-130
 Identities = 251/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 124 SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 183

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 184 MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 238

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 239 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 298

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 299 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 356

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 357 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 416

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 417 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 476

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 477 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 533

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KVVC+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 534 KCYAKVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 587


>gb|AAH85726.1| Txnrd1 protein [Rattus norvegicus]
          Length = 578

 Score =  470 bits (1209), Expect = e-130
 Identities = 251/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 91  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 150

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 151 MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 205

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 206 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 265

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 266 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 323

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 324 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 383

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 384 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 443

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 444 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 500

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KVVC+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 501 KCYAKVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 554


>ref|NP_113802.2| thioredoxin reductase 1, cytoplasmic [Rattus norvegicus]
          Length = 499

 Score =  470 bits (1209), Expect = e-130
 Identities = 251/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KVVC+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKVVCNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>ref|XP_002181543.1| predicted protein [Phaeodactylum tricornutum CCAP 1055/1]
 gb|EEC46757.1| predicted protein [Phaeodactylum tricornutum CCAP 1055/1]
          Length = 630

 Score =  469 bits (1208), Expect = e-130
 Identities = 254/480 (52%), Positives = 309/480 (64%), Gaps = 22/480 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGG+A +KEAA  G KV  LD+VKPSP GT+WGLGGTCVNVGCIPKKL 
Sbjct: 135 YDYDLVVIGGGSGGMAAAKEAAVLGAKVACLDFVKPSPAGTTWGLGGTCVNVGCIPKKLF 194

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFD-------------WKQLVSNVXXXXXXX 108
           H  SL+ E +  D  SFG  +G  NG   T +             W+ +  N+       
Sbjct: 195 HIGSLLHESVRKDTPSFGIRLGEPNGASATDELSGIVPDPSTQMRWELVRENIQNYIRGL 254

Query: 109 XXXXXVELRSKQVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG 168
                V LR K+V Y N L  F D HT++    K  +  IT    ++AVGGRP  L+C G
Sbjct: 255 NFKYRVRLREKEVTYFNKLAKFTDKHTIEAVDKKGRSSLITAARFLVAVGGRPSPLSCEG 314

Query: 169 GELAVSSDDIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDM 228
            E A+SSDD+F M +K PGKTL VGASY++LECAGFL GMG  V V VRSILLRGFD++ 
Sbjct: 315 AEHAISSDDVFAM-EKCPGKTLCVGASYISLECAGFLAGMGLDVTVAVRSILLRGFDREC 373

Query: 229 ASKIGEYMEMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDP 288
           A KIG+YM +  G+ F R  +P  + K+++GQ   K +  DG   EE +DTVL A GR  
Sbjct: 374 ADKIGDYM-VDHGVRFKRDVIPSKLEKIETGQ--TKVLFSDGT--EEVYDTVLAAVGRMA 428

Query: 289 DVAKLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRR 347
           D  KLGL+  GV+ N K  RI    EQT  PN+YAIGDV+D  PELTPVAIQAG  L+RR
Sbjct: 429 DTDKLGLESVGVETNPKNRRIIGKFEQTHCPNIYAIGDVLDKTPELTPVAIQAGLYLARR 488

Query: 348 LYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQ 407
           L+      MDY  +CT VFTPIEY C GLSEED+  +YG +++EVYH+ FVPLEWSL+  
Sbjct: 489 LFGGDKEAMDYQNVCTTVFTPIEYACVGLSEEDAVAKYGQNNIEVYHREFVPLEWSLSMS 548

Query: 408 TRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              +  + Y KV+ DK+    VLG HY+GPNAGEV Q  G +MK G T   L DTVGIHP
Sbjct: 549 R--SHNAAYTKVIVDKSPQENVLGIHYVGPNAGEVMQGYGTSMKQGLTLKTLTDTVGIHP 606


>pdb|3EAN|A Chain A, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|B Chain B, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|C Chain C, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|D Chain D, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|E Chain E, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAN|F Chain F, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Reduced C-Terminal Tail
 pdb|3EAO|A Chain A, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|B Chain B, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|C Chain C, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|D Chain D, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|E Chain E, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
 pdb|3EAO|F Chain F, Crystal Structure Of Recombinant Rat Selenoprotein
           Thioredoxin Reductase 1 With Oxidized C-Terminal Tail
          Length = 499

 Score =  469 bits (1208), Expect = e-130
 Identities = 250/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KV+C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>emb|CAG38744.1| TXNRD1 [Homo sapiens]
          Length = 497

 Score =  469 bits (1208), Expect = e-130
 Identities = 249/474 (52%), Positives = 321/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    ++GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRRIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>ref|NP_898895.2| thioredoxin reductase 3 [Danio rerio]
          Length = 602

 Score =  469 bits (1207), Expect = e-130
 Identities = 250/473 (52%), Positives = 317/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA+ GKKV VLDYV P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPQGTAWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G  +  D   FGW       +  T +W+ + + V            V LR K V
Sbjct: 174 HQTALLGTAM-EDARKFGWEF----AEQVTHNWETMKTAVNNYIGSLNWGYRVSLRDKNV 228

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N    FV+PH +K  + +      T    V+A G RPR L   G  E  ++SDD+F 
Sbjct: 229 NYVNAYAEFVEPHKIKATNKRGKETFYTAAQFVLATGERPRYLGIPGDKEFCITSDDLFS 288

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALEC GFL G+G  V +MVRSILLRGFDQDMA + GEYME   
Sbjct: 289 LPYC-PGKTLVVGASYVALECGGFLAGLGLDVTIMVRSILLRGFDQDMADRAGEYMETH- 346

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++F+RK VP  I +L++G      +    TE  + FE  ++TVL A GRD    K+GLD
Sbjct: 347 GVKFLRKFVPTKIEQLEAGTPGRIKVTAKSTESEEVFEGEYNTVLIAVGRDACTGKIGLD 406

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTV 354
           +AGVK+NEK G++ VN+ EQT  P++YAIGD+++   ELTPVAIQAG+LL+RRLY   T+
Sbjct: 407 KAGVKINEKNGKVPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYAGATM 466

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY  + T VFTP+EYG CG  EE + + YG +++EVYH  F PLE+++  +       
Sbjct: 467 KCDYVNVPTTVFTPMEYGSCGHPEEKAIQMYGQENLEVYHSLFWPLEFTVPGRDN---NK 523

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+K  N  V+GFHYLGPNAGEVTQ  G AMK G T DQL +T+GIHP
Sbjct: 524 CYAKIICNKLDNLRVIGFHYLGPNAGEVTQGFGAAMKCGITKDQLDNTIGIHP 576


>gb|AAH54599.1| Thioredoxin reductase 1 [Danio rerio]
 gb|AAI65853.1| Txnrd1 protein [Danio rerio]
          Length = 600

 Score =  469 bits (1207), Expect = e-130
 Identities = 250/473 (52%), Positives = 317/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA+ GKKV VLDYV P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPQGTAWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G  +  D   FGW       +  T +W+ + + V            V LR K V
Sbjct: 174 HQTALLGTAM-EDARKFGWEF----AEQVTHNWETMKTAVNNYIGSLNWGYRVSLRDKNV 228

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N    FV+PH +K  + +      T    V+A G RPR L   G  E  ++SDD+F 
Sbjct: 229 NYVNAYAEFVEPHKIKATNKRGKETFYTAAQFVLATGERPRYLGIPGDKEFCITSDDLFS 288

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALEC GFL G+G  V +MVRSILLRGFDQDMA + GEYME   
Sbjct: 289 LPYC-PGKTLVVGASYVALECGGFLAGLGLDVTIMVRSILLRGFDQDMADRAGEYMETH- 346

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++F+RK VP  I +L++G      +    TE  + FE  ++TVL A GRD    K+GLD
Sbjct: 347 GVKFLRKFVPTKIEQLEAGTPGRIKVTAKSTESEEVFEGEYNTVLIAVGRDACTGKIGLD 406

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTV 354
           +AGVK+NEK G++ VN+ EQT  P++YAIGD+++   ELTPVAIQAG+LL+RRLY   T+
Sbjct: 407 KAGVKINEKNGKVPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYAGATM 466

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY  + T VFTP+EYG CG  EE + + YG +++EVYH  F PLE+++  +       
Sbjct: 467 KCDYVNVPTTVFTPMEYGSCGHPEEKAIQMYGQENLEVYHSLFWPLEFTVPGRDN---NK 523

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+K  N  V+GFHYLGPNAGEVTQ  G AMK G T DQL +T+GIHP
Sbjct: 524 CYAKIICNKLDNLRVIGFHYLGPNAGEVTQGFGAAMKCGITKDQLDNTIGIHP 576


>gb|AAI54785.1| Thioredoxin reductase 1 [Danio rerio]
          Length = 602

 Score =  469 bits (1206), Expect = e-130
 Identities = 250/473 (52%), Positives = 317/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLACSKEAA+ GKKV VLDYV P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 114 YDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPQGTAWGLGGTCVNVGCIPKKLM 173

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G  +  D   FGW       +  T +W+ + + V            V LR K V
Sbjct: 174 HQTALLGTAM-EDARKFGWEF----AEQVTHNWETMKTAVNNYIGSLNWGYRVSLRDKNV 228

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N    FV+PH +K  + +      T    V+A G RPR L   G  E  ++SDD+F 
Sbjct: 229 NYVNAYAEFVEPHKIKATNKRGKETFYTAAQFVLATGERPRYLGIPGDKEFCITSDDLFS 288

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALEC GFL G+G  V +MVRSILLRGFDQDMA + GEYME   
Sbjct: 289 LPYC-PGKTLVVGASYVALECGGFLAGLGLDVTIMVRSILLRGFDQDMADRAGEYMETH- 346

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++F+RK VP  I +L++G      +    TE  + FE  ++TVL A GRD    K+GLD
Sbjct: 347 GVKFLRKFVPTKIEQLEAGTPGRIKVTAKSTESEEFFEGEYNTVLIAVGRDACTGKIGLD 406

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTV 354
           +AGVK+NEK G++ VN+ EQT  P++YAIGD+++   ELTPVAIQAG+LL+RRLY   T+
Sbjct: 407 KAGVKINEKNGKVPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYAGATM 466

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY  + T VFTP+EYG CG  EE + + YG +++EVYH  F PLE+++  +       
Sbjct: 467 KCDYVNVPTTVFTPMEYGSCGHPEEKAIQMYGQENLEVYHSLFWPLEFTVPGRDN---NK 523

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+K  N  V+GFHYLGPNAGEVTQ  G AMK G T DQL +T+GIHP
Sbjct: 524 CYAKIICNKLDNLRVIGFHYLGPNAGEVTQGFGAAMKCGITKDQLDNTIGIHP 576


>ref|NP_999319.2| thioredoxin reductase 1, cytoplasmic [Sus scrofa]
          Length = 499

 Score =  468 bits (1205), Expect = e-130
 Identities = 248/473 (52%), Positives = 319/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA F K+V VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 70

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GWNV     +    DW+++   V            V LR K+V
Sbjct: 71  HQAALLGQALR-DSRNYGWNVE----ETIKHDWERMTEAVQNHIGSLNWGYRVALREKKV 125

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 126 TYENAYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFS 185

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME + 
Sbjct: 186 LPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EH 243

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++FIR+ VP  + ++++G      +    T   +  E  ++TVL A GRD     +GL+
Sbjct: 244 GVKFIRQFVPIKVEQIEAGMPGRLRVTAKATNSDETIEGEYNTVLLAIGRDACTRNIGLE 303

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
             GV++NEKTG+I V + EQT  P VY IGD+++  PELTPVAIQAGRLL++RLY   TV
Sbjct: 304 TVGVEINEKTGKIPVTDEEQTNVPYVYTIGDILEGKPELTPVAIQAGRLLAQRLYGGSTV 363

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G++++E+YH  F PLEW++  +       
Sbjct: 364 KCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEIYHSYFWPLEWTIPSRDN---NK 420

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K+VC+   N  V+GFH LGPNAGEVTQ    A+K G T DQL  T+GIHP
Sbjct: 421 CYAKIVCNIKDNERVVGFHILGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHP 473


>gb|AAN06824.1| thioredoxin reductase [Sus scrofa]
          Length = 480

 Score =  468 bits (1205), Expect = e-130
 Identities = 248/473 (52%), Positives = 319/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA F K+V VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 5   YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 64

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GWNV     +    DW+++   V            V LR K+V
Sbjct: 65  HQAALLGQALR-DSRNYGWNVE----ETIKHDWERMTEAVQNHIGSLNWGYRVALREKKV 119

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 120 TYENAYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFS 179

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME + 
Sbjct: 180 LPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EH 237

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++FIR+ VP  + ++++G      +    T   +  E  ++TVL A GRD     +GL+
Sbjct: 238 GVKFIRQFVPIKVEQIEAGMPGRLRVTAKATNSDETIEGEYNTVLLAIGRDACTRNIGLE 297

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
             GV++NEKTG+I V + EQT  P VY IGD+++  PELTPVAIQAGRLL++RLY   TV
Sbjct: 298 TVGVEINEKTGKIPVTDEEQTNVPYVYTIGDILEGKPELTPVAIQAGRLLAQRLYGGSTV 357

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G++++E+YH  F PLEW++  +       
Sbjct: 358 KCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEIYHSYFWPLEWTIPSRDN---NK 414

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K+VC+   N  V+GFH LGPNAGEVTQ    A+K G T DQL  T+GIHP
Sbjct: 415 CYAKIVCNIKDNERVVGFHILGPNAGEVTQGFAAALKCGLTKDQLDSTIGIHP 467


>ref|XP_002752975.1| PREDICTED: thioredoxin reductase 1, cytoplasmic isoform 2
           [Callithrix jacchus]
          Length = 549

 Score =  467 bits (1202), Expect = e-129
 Identities = 247/473 (52%), Positives = 321/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 63  YDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 122

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+V
Sbjct: 123 HQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKV 177

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 178 VYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFS 237

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTL+VGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME + 
Sbjct: 238 LPYC-PGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EH 295

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           GI+FIR+ VP  + ++++G      +V   T + +  E  ++TVL A GRD    K+GL+
Sbjct: 296 GIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNNEEIIEGEYNTVLLAIGRDACTRKIGLE 355

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTV 354
             GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   TV
Sbjct: 356 TVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKVELTPVAIQAGRLLAQRLYAGSTV 415

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +       
Sbjct: 416 KCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NK 472

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+   +  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 473 CYAKIICNTKDSERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 525


>ref|XP_002752974.1| PREDICTED: thioredoxin reductase 1, cytoplasmic isoform 1
           [Callithrix jacchus]
          Length = 649

 Score =  467 bits (1202), Expect = e-129
 Identities = 247/473 (52%), Positives = 321/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 163 YDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM 222

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+V
Sbjct: 223 HQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKV 277

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 278 VYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFS 337

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTL+VGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME + 
Sbjct: 338 LPYC-PGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EH 395

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           GI+FIR+ VP  + ++++G      +V   T + +  E  ++TVL A GRD    K+GL+
Sbjct: 396 GIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNNEEIIEGEYNTVLLAIGRDACTRKIGLE 455

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTV 354
             GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   TV
Sbjct: 456 TVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKVELTPVAIQAGRLLAQRLYAGSTV 515

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +       
Sbjct: 516 KCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NK 572

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+   +  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 573 CYAKIICNTKDSERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 625


>dbj|BAC87474.1| unnamed protein product [Homo sapiens]
          Length = 581

 Score =  467 bits (1202), Expect = e-129
 Identities = 249/474 (52%), Positives = 320/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VL +V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 109 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLVFVTPTPLGTRWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 169 MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 223

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 224 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 283

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 284 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 341

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 342 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 401

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 402 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 461

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 462 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 518

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 519 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 572


>ref|XP_001507796.1| PREDICTED: similar to thioredoxin reductase 1 [Ornithorhynchus
           anatinus]
          Length = 621

 Score =  467 bits (1201), Expect = e-129
 Identities = 250/474 (52%), Positives = 317/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           S+DYDL+VIGGGSGGLA +KEAA +GKKV VLD+V P+P G  WGLGGTCVNVGCIPKKL
Sbjct: 134 SFDYDLIVIGGGSGGLAAAKEAAKYGKKVMVLDFVTPTPLGNRWGLGGTCVNVGCIPKKL 193

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   +GW V     +    +W+ +   V            V LR  +
Sbjct: 194 MHQAALLGQALQ-DSRKYGWQVE----ETVKHNWESMTEAVQNYIGSLNWGYRVALRENK 248

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGE-LAVSSDDIF 179
           V YEN  G FV PH +K  + K      T    +IA G RPR L   G +   +SSDD+F
Sbjct: 249 VTYENAYGEFVGPHKIKATNQKGKENFYTAEKFLIATGERPRYLGIPGDKKYCISSDDLF 308

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 309 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 366

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FI+K VP  I +++ G      +V   T+  +  E  ++TVL A GRD    K+GL
Sbjct: 367 HGIKFIKKFVPIKIEQIEEGMPGKLKVVAQSTDGQETIEGEYNTVLLAVGRDSCTRKIGL 426

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGDV++   ELTPVAIQAGRLL+RRLY+  T
Sbjct: 427 ENVGVKINEKTGKIPVTDEEQTNVPYIYAIGDVLEGKLELTPVAIQAGRLLARRLYSGST 486

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYG CG SEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 487 VKCDYDNVPTTVFTPLEYGACGFSEEKAAEKFGEENIEVYHSYFWPLEWTVPSRDN---N 543

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T +QL  T+GIHP
Sbjct: 544 KCYAKIICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKEQLDSTIGIHP 597


>gb|AAF15900.1|AF208018_1 thioredoxin reductase [Homo sapiens]
          Length = 497

 Score =  466 bits (1199), Expect = e-129
 Identities = 248/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KE A +GKKV VLD+  P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEPAQYGKKVMVLDFGTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>sp|Q9MYY8|TRXR1_PIG RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
 gb|AAF78791.1|AF277894_1 redox enzyme thioredoxin reductase [Sus scrofa]
          Length = 499

 Score =  466 bits (1199), Expect = e-129
 Identities = 249/473 (52%), Positives = 319/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA F K+V VLD+V P+P GT WGLGGTCVNV CIPKKLM
Sbjct: 11  YDYDLIIIGGGSGGLAAAKEAARFNKRVMVLDFVTPTPLGTRWGLGGTCVNVSCIPKKLM 70

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GWNV     +    DW+++   V            V LR K+V
Sbjct: 71  HQAALLGQALR-DSRNYGWNVE----ETIKHDWERMTEAVQNHIGSLNWGYRVALREKKV 125

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 126 TYENAYGQFVGPHRIKATNNKGKEKIYSAEKFLIATGERPRYLGIPGDKEYCISSDDLFS 185

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME + 
Sbjct: 186 LPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EH 243

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           GI+FIR+ VP  + ++++G      +V   T   +  E  ++TV+ A GRD    K+GL+
Sbjct: 244 GIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLE 303

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTV 354
             GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   TV
Sbjct: 304 TVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTV 363

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +       
Sbjct: 364 KCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NK 420

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 421 CYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>ref|NP_001087786.1| thioredoxin reductase 1 [Xenopus laevis]
 gb|AAH81224.1| MGC85342 protein [Xenopus laevis]
          Length = 531

 Score =  466 bits (1198), Expect = e-129
 Identities = 253/473 (53%), Positives = 322/473 (68%), Gaps = 16/473 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLA SKEAA +GKKV VLD+V PSP GT WGLGGTCVNVGCIPKKL
Sbjct: 45  TYDYDLIVIGGGSGGLAASKEAAKYGKKVLVLDFVTPSPLGTKWGLGGTCVNVGCIPKKL 104

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+ + L  D   +GW +   N Q    +W+ +  +V            V L    
Sbjct: 105 MHQAALLRQALK-DSQKYGWQIAD-NIQ---HNWETMTDSVQNYIGSLNFNYRVALMENN 159

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           VKYEN  G FV P+T+K  + +  +K  T    +IA G RPR L   G  E  ++SDD+F
Sbjct: 160 VKYENGYGEFVGPNTIKSTNSRGKSKYFTAEKFLIATGERPRYLGIPGDKEYCITSDDLF 219

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ MA+KIGEYME +
Sbjct: 220 SLTYC-PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQQMANKIGEYME-E 277

Query: 240 SGIEFIRKTVPQSITKLDS---GQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
            G++FIR+ VP  I ++++   G+L V     DG    + ++TVL A GRD     +GL+
Sbjct: 278 HGVKFIRQFVPTKIEQIEAGMPGRLKVTSQAPDGTETTDEYNTVLLAIGRDACTRNIGLE 337

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTV 354
             GVK+NEKTG+I VN+ EQT  P +YAIGDVI D  ELTPVAIQAGRLL++RLY + T+
Sbjct: 338 IPGVKINEKTGKIPVNDEEQTNVPYIYAIGDVIQDKLELTPVAIQAGRLLAKRLYGDSTL 397

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY  + T VFTP+EYG CGLSEE++  +YG+++VEVYH  F PLEW++  +       
Sbjct: 398 KSDYVNVPTTVFTPLEYGACGLSEENAIRQYGEENVEVYHSYFWPLEWTVPARDN---NK 454

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+   N  V+GFH L PNAGE+TQ   +A+K G T DQL +T+GIHP
Sbjct: 455 CYAKIICNLKDNERVVGFHVLSPNAGEITQGFAVAIKCGLTKDQLDNTIGIHP 507


>gb|AAC35244.2| thioredoxin reductase [Rattus norvegicus]
          Length = 497

 Score =  465 bits (1197), Expect = e-129
 Identities = 249/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KV+C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>ref|XP_001365687.1| PREDICTED: similar to Thioredoxin reductase 1, cytoplasmic (TR)
           (TR1) [Monodelphis domestica]
          Length = 497

 Score =  465 bits (1196), Expect = e-129
 Identities = 251/474 (52%), Positives = 315/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGLA +KEAA +GKK+ VLD+V P+P G  WGLGGTCVNVGCIPKKL
Sbjct: 10  AYDYDLIIIGGGSGGLAAAKEAARYGKKILVLDFVTPTPLGNRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   +GW +     +    +W+ +   V            V LR  +
Sbjct: 70  MHQAALLGQALQ-DSRKYGWQLS----EEVKHNWESMTEAVQNYIGSLNWGYRVALRENR 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G FV PH +K  + K   K  T    +IA G RPR     G  E  +SSDD+F
Sbjct: 125 VTYENAYGEFVGPHKIKATNNKGKEKFYTAERFLIATGERPRYPGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME  
Sbjct: 185 SLSYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-D 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FI+K VP  I ++  G      +V   T+  +  E  ++TVL A GRD    K+GL
Sbjct: 243 HGIKFIKKFVPIKIEQIKEGTPGTLRVVAQSTDGKETIEGEYNTVLLAIGRDSCTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I VN+ EQT  P +YAIGDV+ D  ELTPVAIQAGRLL+RRLY   T
Sbjct: 303 ETVGVKINEKTGKIPVNDEEQTNVPYIYAIGDVLEDKLELTPVAIQAGRLLARRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           ++ DYD + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 IKCDYDNVPTTVFTPLEYGACGLSEERAVEKFGEENIEVYHSYFWPLEWTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KV+C    N  V+GFH LGPNAGEVTQ    A+K G T +QL  T+GIHP
Sbjct: 420 KCYAKVICHVRDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKNQLDSTIGIHP 473


>dbj|BAE26918.1| unnamed protein product [Mus musculus]
          Length = 497

 Score =  465 bits (1196), Expect = e-129
 Identities = 250/474 (52%), Positives = 318/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKVEDT----VKHDWEKMTESVQSHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEET----FDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +T      EET    F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIERIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSN 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   +  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>gb|EDL21377.1| thioredoxin reductase 1, isoform CRA_b [Mus musculus]
          Length = 611

 Score =  464 bits (1195), Expect = e-128
 Identities = 250/474 (52%), Positives = 318/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 124 SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 183

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V          DW+++  +V            V LR K+
Sbjct: 184 MHQAALLGQALK-DSRNYGWKVEDT----VKHDWEKMTESVQSHIGSLNWGYRVALREKK 238

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 239 VVYENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 298

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 299 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 356

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEET----FDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +T      EET    F+TVL A GRD     +GL
Sbjct: 357 HGIKFIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGL 416

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    
Sbjct: 417 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSN 476

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 477 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 533

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   +  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 534 KCYAKIICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 587


>gb|AAH37643.1| Thioredoxin reductase 1 [Mus musculus]
 dbj|BAE40292.1| unnamed protein product [Mus musculus]
 gb|EDL21375.1| thioredoxin reductase 1, isoform CRA_a [Mus musculus]
 gb|EDL21376.1| thioredoxin reductase 1, isoform CRA_a [Mus musculus]
          Length = 497

 Score =  464 bits (1195), Expect = e-128
 Identities = 250/474 (52%), Positives = 318/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKVEDT----VKHDWEKMTESVQSHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEET----FDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +T      EET    F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSN 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   +  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>ref|NP_001035988.1| thioredoxin reductase 1, cytoplasmic isoform 1 [Mus musculus]
 sp|Q9JMH6|TRXR1_MOUSE RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=Thioredoxin reductase TR1
 gb|AAK01140.1|AF333036_1 thioredoxin reductase 1 [Mus musculus]
          Length = 613

 Score =  464 bits (1195), Expect = e-128
 Identities = 250/474 (52%), Positives = 318/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 124 SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 183

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V          DW+++  +V            V LR K+
Sbjct: 184 MHQAALLGQALK-DSRNYGWKVEDT----VKHDWEKMTESVQSHIGSLNWGYRVALREKK 238

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 239 VVYENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 298

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 299 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 356

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEET----FDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +T      EET    F+TVL A GRD     +GL
Sbjct: 357 HGIKFIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGL 416

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    
Sbjct: 417 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSN 476

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 477 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 533

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   +  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 534 KCYAKIICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 587


>ref|NP_056577.2| thioredoxin reductase 1, cytoplasmic isoform 2 [Mus musculus]
 ref|NP_001035978.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Mus musculus]
 ref|NP_001035979.1| thioredoxin reductase 1, cytoplasmic isoform 2 [Mus musculus]
 dbj|BAA86985.2| thioredoxin reductase 1 [Mus musculus]
          Length = 499

 Score =  464 bits (1195), Expect = e-128
 Identities = 250/474 (52%), Positives = 318/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKVEDT----VKHDWEKMTESVQSHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEET----FDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +T      EET    F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSN 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   +  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNLKDDERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHP 473


>gb|AAI67349.1| MGC147163 protein [Xenopus (Silurana) tropicalis]
          Length = 596

 Score =  464 bits (1193), Expect = e-128
 Identities = 247/474 (52%), Positives = 324/474 (68%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLACSKEAASFGKKV VLDYV P+P GTSWGLGGTCVNVGCIPKKL
Sbjct: 109 TYDYDLIVIGGGSGGLACSKEAASFGKKVMVLDYVVPTPKGTSWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++++G+ L  D  +FGW       +    +W  +   +            V LR KQ
Sbjct: 169 MHQAAILGQSL-KDSRNFGWEY----EEQVKHNWDTMREAIQNYIGSLNWGYRVSLRDKQ 223

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+YEN  G FV+PH +K  + +      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 224 VRYENAYGEFVEPHKIKATNKRGKESFFTAEKFVVATGERPRYLNIPGDKEYCITSDDLF 283

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G    VMVRSILLRGFDQ+MA++ G YME  
Sbjct: 284 SLPYC-PGKTLVVGASYVALECAGFLAGLGLDATVMVRSILLRGFDQEMANRAGAYMETH 342

Query: 240 SGIEFIRKTVPQSITKLDS---GQLLVKWITEDGD-CFEETFDTVLNATGRDPDVAKLGL 295
            G++FI++ VP S+  L+    G+L V     +GD   E+ ++TVL A GRD     +GL
Sbjct: 343 -GVKFIKQFVPISVELLEEGTPGRLKVTAKATEGDQIIEDEYNTVLIAVGRDACTRNIGL 401

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NE+ G+I V++ EQT+ P VYAIGD++D   ELTPVAIQAGRLL+RRLY    
Sbjct: 402 EKIGVKVNERNGKIPVSDEEQTSVPYVYAIGDILDGKLELTPVAIQAGRLLARRLYKGSK 461

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           ++ DY  + T VFTP+EYGCCG +EE + E YG++++EVYH  F PLEW++  +      
Sbjct: 462 LKCDYVNVPTTVFTPLEYGCCGYAEEKAIEIYGEENLEVYHTLFWPLEWTVPSRDN---N 518

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +C+ K++C+K  ++ V+GFH LGPNAGE+TQ  G A+K G T ++L +T+GIHP
Sbjct: 519 TCFAKIICNKQDDDRVVGFHVLGPNAGEITQGFGAAIKCGLTKEKLDETIGIHP 572


>ref|NP_001116145.1| thioredoxin reductase 1, cytoplasmic [Canis lupus familiaris]
          Length = 655

 Score =  462 bits (1190), Expect = e-128
 Identities = 246/473 (52%), Positives = 317/473 (67%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA +KEAA + KK+ VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 167 YDYDLIIIGGGSGGLAAAKEAARYNKKIMVLDFVTPTPRGTRWGLGGTCVNVGCIPKKLM 226

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G+ L  D  ++GW+      +    DW ++   V            V LR K+V
Sbjct: 227 HQAALLGQALQ-DSRNYGWSTE----ETVKHDWDKMTEAVQNHIGSLNWGYRVALREKKV 281

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F 
Sbjct: 282 TYENAYGQFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDREYCISSDDLFS 341

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME + 
Sbjct: 342 LPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-EH 399

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++FIR+ VP  + ++++G      +V   T   +  E  ++TVL A GRD    K+GL+
Sbjct: 400 GVKFIRQFVPIKVEQIEAGTPGRLRVVAQSTSSSETIEGEYNTVLLAIGRDACTRKIGLE 459

Query: 297 EAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTV 354
             GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    V
Sbjct: 460 TVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYAGSNV 519

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLEW++  +       
Sbjct: 520 KCDYENVPTTVFTPLEYGACGLSEERAVEKFGEENIEVYHSYFWPLEWTIPSRDN---NK 576

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY KV+C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 577 CYAKVICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKMQLDSTIGIHP 629


>ref|NP_001087660.1| thioredoxin reductase 3 [Xenopus laevis]
 gb|AAH81053.1| MGC81848 protein [Xenopus laevis]
          Length = 596

 Score =  462 bits (1190), Expect = e-128
 Identities = 246/474 (51%), Positives = 322/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLACSKEAASFGKKV VLD+V P+P GTSWGLGGTCVNVGCIPKKL
Sbjct: 109 TYDYDLIVIGGGSGGLACSKEAASFGKKVMVLDFVVPTPQGTSWGLGGTCVNVGCIPKKL 168

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++++G+ L  D   FGW       +    +W+ +   +            V LR KQ
Sbjct: 169 MHQAAILGQSL-KDSRKFGWEY----EEQVKHNWETMREAIQNYIGSLNWGYRVALRDKQ 223

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+YEN  G FV+ H +K  + K      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 224 VRYENAYGEFVESHKIKATNKKGKESFFTAEKFVVATGERPRYLNIPGDKEYCITSDDLF 283

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G    VMVRSI LRGFDQ+MA++ G YME  
Sbjct: 284 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDATVMVRSIFLRGFDQEMANRAGAYMETH 342

Query: 240 SGIEFIRKTVPQSITKLDS---GQLLVKWITEDGD-CFEETFDTVLNATGRDPDVAKLGL 295
            G++FI++ VP  +  L+    G++ V   +  GD   E+ ++TVL A GRD     +GL
Sbjct: 343 -GVKFIKQFVPIKVELLEEGTPGRIKVTAKSTQGDQIIEDEYNTVLIAVGRDACTRNIGL 401

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NE+ G+I V++ EQT+ P+VYAIGD++D   ELTPVAIQAGRLL+RRLY    
Sbjct: 402 EKIGVKINERNGKIPVSDEEQTSVPHVYAIGDILDGKLELTPVAIQAGRLLARRLYRGSK 461

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY  + T VFTP+EYGCCG +EE + E YG++++EVYH  F PLEW++  +      
Sbjct: 462 VKCDYINVPTTVFTPLEYGCCGYAEEKAIEIYGEENLEVYHTLFWPLEWTVPSRDN---N 518

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +C+ K++C+K  N+ V+GFH LGPNAGE+TQ  G AMK G T ++L +T+GIHP
Sbjct: 519 TCFAKIICNKQDNDRVIGFHVLGPNAGEITQGFGAAMKCGLTKEKLDETIGIHP 572


>emb|CAH92925.2| thioredoxin reductase [Pongo abelii]
          Length = 499

 Score =  462 bits (1189), Expect = e-128
 Identities = 248/474 (52%), Positives = 319/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL++IGGGSGGLA +KEAA +GKKV VLD+V P+P GT WGL GTCVNVGCIPKKL
Sbjct: 10  SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLEGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V     +    DW +++  V            V LR K+
Sbjct: 70  MHQAALLGQALQ-DSRNYGWKVE----ETVKHDWDRMIEAVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTL+VGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLIVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  + ++++G      +V   T   +  E  ++TVL A GRD    K+GL
Sbjct: 243 HGIKFIRQFVPIKVGQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVLLAIGRDACTRKIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD++ D  ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E++G++++EVYH  F PLE ++  +      
Sbjct: 363 VKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLERTIPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 420 KCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 473


>emb|CBN80599.1| Thioredoxin reductase 3 [Dicentrarchus labrax]
          Length = 600

 Score =  462 bits (1188), Expect = e-128
 Identities = 246/474 (51%), Positives = 318/474 (67%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+P GTSWGLGGTCVNVGCIPKKL
Sbjct: 113 AYDYDLIVIGGGSGGLACSKEAAMLGKKVMVLDYVVPTPKGTSWGLGGTCVNVGCIPKKL 172

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  +  D   FGW       +    +W+ + + V            V LR K 
Sbjct: 173 MHQTALLGTAM-QDARKFGWEF----EETVKHNWETMKTAVNNYIGSLNWGYRVALRDKN 227

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N    F++PH +K  + +      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 228 VNYVNAYAEFIEPHKIKATNKRGKETLYTAAKFVLATGERPRYLGIPGDKEYCITSDDLF 287

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLV+GASYVALEC GFL G+G  V VMVRSILLRGFDQDMA++ GE+ME +
Sbjct: 288 SLSYC-PGKTLVIGASYVALECGGFLAGLGLDVTVMVRSILLRGFDQDMANRAGEHME-E 345

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F+RK VP  + +L++G      +    TE  +  E  ++TVL A GRD    K+GL
Sbjct: 346 HGVKFLRKYVPVKVEELEAGTPGRLKVTAKSTESDEIIEGEYNTVLIAVGRDACTDKIGL 405

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           D+AGVK+N K G+I VN+ EQT  P++YAIGD+++   ELTPVAIQAG+LL+RRLY    
Sbjct: 406 DKAGVKVNPKNGKIPVNDEEQTNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYGGSK 465

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           ++ DY  + T VFTP+EYG CGLSEE + E YG +++EVYH    PLE+++  +      
Sbjct: 466 LKCDYINVPTTVFTPLEYGACGLSEERATELYGQENIEVYHSLLWPLEFTVPGRDN---N 522

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+K  N+ V+GFHYLGPNAGEVTQ  G+AMK G T +QL +T+GIHP
Sbjct: 523 RCYSKIICNKLDNDRVIGFHYLGPNAGEVTQGFGVAMKCGATKEQLDNTIGIHP 576


>gb|EFN85970.1| Thioredoxin reductase 1, mitochondrial [Harpegnathos saltator]
          Length = 544

 Score =  462 bits (1188), Expect = e-128
 Identities = 236/468 (50%), Positives = 316/468 (67%), Gaps = 10/468 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLA +KEA   G KV VLDYV PSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 59  YKYDLLVIGGGSGGLAAAKEAVGLGAKVAVLDYVSPSPRGTTWGLGGTCVNVGCIPKKLM 118

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+GE + H+ A+FGW +   + +    DW+ L + V            VELR+K++
Sbjct: 119 HQAALLGEAI-HEAATFGWQL--PDPKTIKIDWEALRTAVQNHVKSVNWVTRVELRTKEI 175

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N LG F D HT+     K   K IT +++++AVGGRPR     G  E  +SSDDIF 
Sbjct: 176 DYINALGHFKDAHTIAGITKKGEEKIITAKNILLAVGGRPRYPDIPGALEYGISSDDIFS 235

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           + +  PGKTLVVGA Y+ LECAGFL G+GY   VMVRSI+LRGFDQ MA+ + E M+ Q 
Sbjct: 236 L-EHAPGKTLVVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMANIVAEEMQ-QR 293

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           G+ FI +  P+ + K D G+LLV W+ +DG+  ++ +DTVL A GR P   +L  + AG+
Sbjct: 294 GVHFIYQAKPKKVAKQDDGRLLVDWVDKDGEVHQDVYDTVLFAIGRRPLTEELKPENAGL 353

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
           KL+ ++G+I   NEQT  PN+YA+GD++   PELTPVAI AG+LL++RL++  + QMDY 
Sbjct: 354 KLHSESGKIEATNEQTNVPNIYAVGDILHKKPELTPVAIHAGKLLAKRLFDNSSEQMDYT 413

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKV 419
            + T VF+P+EYGC GLSEE +   YG++ +EVYH  + P E+ + ++       CYVKV
Sbjct: 414 NVATTVFSPLEYGCVGLSEEAAVAHYGEEEIEVYHAYYKPTEFFVPQKD---VSHCYVKV 470

Query: 420 VCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +  +  +  VLG H++GPNAGEV Q    A+K G T+ +L  TVGIHP
Sbjct: 471 IALRNGDQKVLGMHFVGPNAGEVIQGFSAAVKCGLTFPKLKSTVGIHP 518


>ref|XP_002915522.1| PREDICTED: thioredoxin reductase 1, cytoplasmic-like [Ailuropoda
           melanoleuca]
          Length = 651

 Score =  462 bits (1188), Expect = e-128
 Identities = 243/474 (51%), Positives = 317/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+++GGGSGGLA +KEAA + KK+ VLD+V P+PHGT WGLGGTCVNVGCIPKKL
Sbjct: 164 AYDYDLIIVGGGSGGLAAAKEAAKYDKKIMVLDFVTPTPHGTRWGLGGTCVNVGCIPKKL 223

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW+      +    DW ++   V            V LR K+
Sbjct: 224 MHQAALLGQALR-DSRNYGWDTE----ETVKHDWNKMTEAVQNHIGSLNWGYRVALREKK 278

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 279 VTYENAYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDREYCISSDDLF 338

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 339 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 396

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++FI++ VP  + ++++G      +V   T   +  E  ++TVL A GRD    K+GL
Sbjct: 397 HGVKFIKQFVPIKVEQIEAGTPGRLRVVAKSTSSDETIEGEYNTVLLAIGRDACTRKIGL 456

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEK G+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    
Sbjct: 457 ETVGVKINEKNGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYAGSN 516

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DY+ + T VFTP+EYG CGLSEE + E +G++++EVYH  F PLEW++  +      
Sbjct: 517 VKCDYENVPTTVFTPLEYGACGLSEEKAVETFGEENIEVYHSFFWPLEWTIPSRDN---N 573

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 574 KCYAKIICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 627


>ref|XP_516719.2| PREDICTED: thioredoxin reductase 3 [Pan troglodytes]
          Length = 752

 Score =  461 bits (1187), Expect = e-128
 Identities = 250/475 (52%), Positives = 319/475 (67%), Gaps = 19/475 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 265 AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 324

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 325 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMTKAIQNHISSLNWGYRLSLREKA 379

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 380 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 439

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 440 SLPYC-PGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 497

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 498 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 556

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL+RRL+   
Sbjct: 557 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLARRLFGAS 616

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
             + DY  + T VFTP+EYGCCGLSEE + E Y  +++E+YH  F PLEW++A +     
Sbjct: 617 LEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN--- 673

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 674 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 728


>gb|AAH30028.1| TXNRD3 protein [Homo sapiens]
          Length = 678

 Score =  461 bits (1186), Expect = e-127
 Identities = 249/475 (52%), Positives = 320/475 (67%), Gaps = 19/475 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 191 AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 250

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ ++  +            + LR K 
Sbjct: 251 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMIKAIQNHISSLNWGYRLSLREKA 305

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 306 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 365

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 366 SLPYC-PGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 423

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 424 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 482

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL++RL+   
Sbjct: 483 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGAS 542

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
             + DY  + T VFTP+EYGCCGLSEE + E Y  +++E+YH  F PLEW++A +     
Sbjct: 543 LEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN--- 599

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 600 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 654


>ref|XP_002923145.1| PREDICTED: thioredoxin reductase 3-like [Ailuropoda melanoleuca]
          Length = 656

 Score =  461 bits (1185), Expect = e-127
 Identities = 248/474 (52%), Positives = 316/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PSP GTSWGLGGTCVNVGC+PKKL
Sbjct: 169 AYDYDLIVIGGGSGGLACAQEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCVPKKL 228

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       Q    +W+ +   +            + LR K 
Sbjct: 229 MHQAALLGQAL-SDARKFGWEY----HQQVKHNWETMTEAIQNHIGSLNWGYRLSLREKA 283

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 284 VAYVNSYGEFVEHHKIKATNRKGQETYYTAAKFVLATGERPRYLGIRGDKEYCITSDDLF 343

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 344 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 401

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F+RK +P  + +L+ G      +V   TE  +  EE ++TVL A GRD    K+GL
Sbjct: 402 HGVKFLRKFIPVLVQQLEKGSPGKLKVVAKSTEGPETIEEIYNTVLLAIGRDSCTRKIGL 461

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK+G+I VN+ EQT  P VYA+GD+++   ELTPVAIQAG+LL+RRL+    
Sbjct: 462 EKIGVKINEKSGKIPVNDMEQTNVPYVYAVGDILEGKLELTPVAIQAGKLLARRLFAGRL 521

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 522 EKCDYVNVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEVYHTLFWPLEWTVAGRDN---N 578

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGE+TQ    AMK G T  QL DT+GIHP
Sbjct: 579 TCYAKIICNKFDNYRVIGFHVLGPNAGEITQGFAAAMKCGLTKQQLDDTIGIHP 632


>gb|EFB23450.1| hypothetical protein PANDA_012236 [Ailuropoda melanoleuca]
          Length = 540

 Score =  461 bits (1185), Expect = e-127
 Identities = 248/474 (52%), Positives = 316/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PSP GTSWGLGGTCVNVGC+PKKL
Sbjct: 53  AYDYDLIVIGGGSGGLACAQEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCVPKKL 112

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       Q    +W+ +   +            + LR K 
Sbjct: 113 MHQAALLGQAL-SDARKFGWEY----HQQVKHNWETMTEAIQNHIGSLNWGYRLSLREKA 167

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 168 VAYVNSYGEFVEHHKIKATNRKGQETYYTAAKFVLATGERPRYLGIRGDKEYCITSDDLF 227

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 228 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 285

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F+RK +P  + +L+ G      +V   TE  +  EE ++TVL A GRD    K+GL
Sbjct: 286 HGVKFLRKFIPVLVQQLEKGSPGKLKVVAKSTEGPETIEEIYNTVLLAIGRDSCTRKIGL 345

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK+G+I VN+ EQT  P VYA+GD+++   ELTPVAIQAG+LL+RRL+    
Sbjct: 346 EKIGVKINEKSGKIPVNDMEQTNVPYVYAVGDILEGKLELTPVAIQAGKLLARRLFAGRL 405

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 406 EKCDYVNVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEVYHTLFWPLEWTVAGRDN---N 462

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGE+TQ    AMK G T  QL DT+GIHP
Sbjct: 463 TCYAKIICNKFDNYRVIGFHVLGPNAGEITQGFAAAMKCGLTKQQLDDTIGIHP 516


>gb|AAF32362.1|AF220760_1 thioredoxin reductase 1 [Rattus norvegicus]
          Length = 498

 Score =  461 bits (1185), Expect = e-127
 Identities = 249/474 (52%), Positives = 320/474 (67%), Gaps = 18/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KV+C+   N  V+GFH LGPNAGEVTQA+   +K G T  QL  T+GIHP
Sbjct: 420 KCYAKVICNLKDNERVVGFHVLGPNAGEVTQAL-QPLKCGLTKQQLDSTIGIHP 472


>gb|AAD43039.1|AF108213_1 NADPH-dependent thioredoxin reductase [Rattus norvegicus]
          Length = 496

 Score =  461 bits (1185), Expect = e-127
 Identities = 249/474 (52%), Positives = 320/474 (67%), Gaps = 18/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KV+C+   N  V+GFH LGPNAGEVTQA+   +K G T  QL  T+GIHP
Sbjct: 420 KCYAKVICNLKDNERVVGFHVLGPNAGEVTQAL-QPLKCGLTKQQLDSTIGIHP 472


>sp|Q86VQ6|TRXR3_HUMAN RecName: Full=Thioredoxin reductase 3; AltName: Full=Thioredoxin
           and glutathione reductase; AltName: Full=Thioredoxin
           reductase TR2
          Length = 682

 Score =  460 bits (1183), Expect = e-127
 Identities = 249/475 (52%), Positives = 319/475 (67%), Gaps = 19/475 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 193 AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 252

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 253 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMTKAIQNHISSLNWGYRLSLREKA 307

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 308 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 367

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 368 SLPYC-PGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 425

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 426 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 484

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL++RL+   
Sbjct: 485 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGAS 544

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
             + DY  + T VFTP+EYGCCGLSEE + E Y  +++E+YH  F PLEW++A +     
Sbjct: 545 LEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN--- 601

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 602 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 656


>ref|NP_443115.1| thioredoxin reductase 3 isoform 1 [Homo sapiens]
          Length = 643

 Score =  460 bits (1183), Expect = e-127
 Identities = 249/475 (52%), Positives = 319/475 (67%), Gaps = 19/475 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 154 AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 213

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 214 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMTKAIQNHISSLNWGYRLSLREKA 268

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 269 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 328

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 329 SLPYC-PGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 386

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 387 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 445

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL++RL+   
Sbjct: 446 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGAS 505

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
             + DY  + T VFTP+EYGCCGLSEE + E Y  +++E+YH  F PLEW++A +     
Sbjct: 506 LEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN--- 562

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 563 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 617


>sp|O89049|TRXR1_RAT RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR;
           AltName: Full=NADPH-dependent thioredoxin reductase;
           AltName: Full=Thioredoxin reductase TR1
          Length = 498

 Score =  460 bits (1183), Expect = e-127
 Identities = 249/474 (52%), Positives = 318/474 (67%), Gaps = 18/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT+ GLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTNGGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW +          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKLEDT----VKHDWEKMTESVQNHIGSLNWGYRVALREKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +    T   +  E+ F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY   T
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGST 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY KV+C+   N  V+GFH LGPNAGEVTQ    A K G T  QL  T+GIHP
Sbjct: 420 KCYAKVICNLKDNERVVGFHVLGPNAGEVTQGFA-AAKCGLTKQQLDSTIGIHP 472


>gb|AAH50032.1| TXNRD3 protein [Homo sapiens]
          Length = 681

 Score =  460 bits (1183), Expect = e-127
 Identities = 249/475 (52%), Positives = 319/475 (67%), Gaps = 19/475 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 194 AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 253

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 254 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMTKAIQNHISSLNWGYRLSLREKA 308

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 309 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 368

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 369 SLPYC-PGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 426

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 427 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 485

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL++RL+   
Sbjct: 486 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGAS 545

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
             + DY  + T VFTP+EYGCCGLSEE + E Y  +++E+YH  F PLEW++A +     
Sbjct: 546 LEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN--- 602

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 603 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 657


>gb|AAD51325.1|AF171055_1 thioredoxin reductase TR2 [Homo sapiens]
          Length = 579

 Score =  460 bits (1183), Expect = e-127
 Identities = 249/475 (52%), Positives = 319/475 (67%), Gaps = 19/475 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 90  AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 149

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 150 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMTKAIQNHISSLNWGYRLSLREKA 204

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 205 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 264

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 265 SLPYC-PGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 322

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 323 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 381

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL++RL+   
Sbjct: 382 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGAS 441

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
             + DY  + T VFTP+EYGCCGLSEE + E Y  +++E+YH  F PLEW++A +     
Sbjct: 442 LEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN--- 498

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 499 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 553


>ref|XP_002938124.1| PREDICTED: thioredoxin reductase 1, cytoplasmic-like [Xenopus
           (Silurana) tropicalis]
          Length = 651

 Score =  459 bits (1182), Expect = e-127
 Identities = 250/472 (52%), Positives = 318/472 (67%), Gaps = 16/472 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA SKEAA++GKKV VLD+V P+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 166 YDYDLIVIGGGSGGLAASKEAANYGKKVLVLDFVTPTPLGTKWGLGGTCVNVGCIPKKLM 225

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+ + L  D   +GW +   N Q    +W+ +  +V            V L    V
Sbjct: 226 HQAALLRQALK-DSQKYGWQIED-NIQ---HNWEIMTDSVLNYIGSLNFNYRVSLMQNNV 280

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           KYEN  G FV+PHT+K  + +   K  T    +IA G RPR L   G  E  ++SDD+F 
Sbjct: 281 KYENGYGEFVEPHTIKSTNSRGKEKYFTAEKFLIATGERPRYLGIPGDKEYCITSDDLFS 340

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ MA+ IGEYME + 
Sbjct: 341 LPYC-PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQQMANMIGEYME-EH 398

Query: 241 GIEFIRKTVPQSITKLDS---GQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           G++FI++ VP  I ++++   G+L V     DG    E ++TVL A GRD     +GL+ 
Sbjct: 399 GVKFIKQCVPTKIEQIEAGTPGRLKVTSQASDGAETTEEYNTVLLAIGRDACTRNIGLEI 458

Query: 298 AGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
            GVK+NEKTG+I VN+ EQT  P +YAIGDV+ D  ELTPVAIQAGRLL+RRLY + TV+
Sbjct: 459 PGVKINEKTGKIPVNDEEQTNVPYIYAIGDVLQDKLELTPVAIQAGRLLARRLYGDSTVK 518

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
            DY  + T VFTP+EYG CGLSEE +  +Y ++++EVYH  F PLEW++  +       C
Sbjct: 519 CDYVNVPTTVFTPLEYGACGLSEEHAIRQYEEENIEVYHSYFWPLEWTVPARDN---NKC 575

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y K++C+      V+GFH L PNAGE+TQ   +A+K G T DQL +T+GIHP
Sbjct: 576 YAKIICNLKDKGRVVGFHVLSPNAGEITQGFAVAIKCGLTKDQLDNTIGIHP 627


>ref|NP_001116249.1| thioredoxin reductase 3 [Gallus gallus]
          Length = 606

 Score =  459 bits (1182), Expect = e-127
 Identities = 249/474 (52%), Positives = 314/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLACSKEAA+ GKKV VLDYV P+P GTSWGLGGTCVNVGCIPKKL
Sbjct: 117 TYDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPLGTSWGLGGTCVNVGCIPKKL 176

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW       +    +W+ +V  V            + LR K 
Sbjct: 177 MHQAALLGQAL-KDSRAYGWQY----DEQVKHNWEIMVEAVQNYIGSLNWGYRLSLREKS 231

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y+N  G FV+PH +K  + K      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 232 VTYQNSYGEFVEPHKIKATNRKGQVTYHTAETFVLATGERPRYLGIPGDKEYCITSDDLF 291

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ+MA KIG +ME  
Sbjct: 292 SLPYC-PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEMAEKIGAHMETH 350

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G+ FIRK VP  + +L+ G      +    TE  + FE  ++TVL A GRD     +GL
Sbjct: 351 -GVTFIRKFVPTQVERLEDGTPGRLKVTAKSTEGPEFFEGEYNTVLIAIGRDACTRNIGL 409

Query: 296 DEAGVKLNEKTGRIWVNNEQ-TTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
              GVK+NEK G++ VN+E+ T  P VYAIGD++D   ELTPVAIQAG+LL+RRLY   +
Sbjct: 410 QTIGVKINEKNGKVPVNDEERTNVPYVYAIGDILDGKLELTPVAIQAGKLLARRLYGGSS 469

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYG CGL+EE + EEYG  ++EVYH  F PLEW++  +      
Sbjct: 470 TKCDYINVPTTVFTPLEYGSCGLAEEKAIEEYGKQNLEVYHSLFWPLEWTVPGRDN---N 526

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K   N V+GFH LGPNAGEVTQ    A+K G T + L +T+GIHP
Sbjct: 527 TCYAKIICNKLDGNRVVGFHVLGPNAGEVTQGFAAAIKCGLTKELLDETIGIHP 580


>ref|NP_001116250.1| thioredoxin reductase 3 [Canis lupus familiaris]
          Length = 586

 Score =  459 bits (1180), Expect = e-127
 Identities = 249/474 (52%), Positives = 314/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 97  AYDYDLIVIGGGSGGLACAQEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 156

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       Q     W+ +   +            + LR K 
Sbjct: 157 MHQAALLGQAL-RDARKFGWEY----SQQVKHTWETMTEAIQNHIGSLNWGYRLSLREKA 211

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 212 VAYVNSYGEFVEHHKIKATNRKGQETCYTAAKFVLATGQRPRYLGIQGDKEYCITSDDLF 271

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V +MVRSILLRGFDQ+MA K+G YME Q
Sbjct: 272 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTIMVRSILLRGFDQEMAEKVGSYME-Q 329

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F+RK VP  + +L+ G      +V   TE  +  EE ++TVL A GRD    K+GL
Sbjct: 330 HGVKFLRKFVPVLVQQLEKGSPGKLKVVAKSTEGPETIEEIYNTVLLAIGRDSCTRKIGL 389

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK+G+I VN+ EQT  P VYA+GD+++   ELTPVAIQAG+LL+RRL+    
Sbjct: 390 EKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEGKLELTPVAIQAGKLLARRLFAGRL 449

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 450 EKCDYVNVPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---N 506

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 507 TCYAKIICNKLDNYRVIGFHVLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 560


>gb|AAD39929.1|AF133519_1 thioredoxin reductase 3 [Homo sapiens]
          Length = 577

 Score =  457 bits (1177), Expect = e-126
 Identities = 248/475 (52%), Positives = 318/475 (66%), Gaps = 19/475 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 88  AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 147

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 148 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMTKAIQNHISSLNWGYRLSLREKA 202

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 203 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 262

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGK LVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 263 SLPYC-PGKPLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 320

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 321 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 379

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL++RL+   
Sbjct: 380 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRLFGAS 439

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
             + DY  + T VFTP+EYGCCGLSEE + E Y  +++E+YH  F PLEW++A +     
Sbjct: 440 LEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTLFWPLEWTVAGREN--- 496

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 497 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 551


>ref|XP_001492801.1| PREDICTED: similar to thioredoxin reductase 3 [Equus caballus]
          Length = 565

 Score =  456 bits (1174), Expect = e-126
 Identities = 253/474 (53%), Positives = 315/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLAC++EAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 78  AYDYDLIVIGGGSGGLACAQEAAVLGKKVMVLDFVLPSPQGTSWGLGGTCVNVGCIPKKL 137

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 138 MHQAALLGQAL-IDSRKFGW---EYNQQV-KHNWETMTEAIQNHIGSLNWGYRLSLREKA 192

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 193 VAYVNSYGEFVEHHKIKATNRKGQETCYTAAKFVIATGERPRYLGIQGDKEYCITSDDLF 252

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 253 SLPYC-PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 310

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F+RK VP  I +L+ G      +V   TE     E  ++TVL A GRD    K+GL
Sbjct: 311 HGVKFLRKFVPVMIQQLEKGSPGKLRVVAESTEGPGAVEGVYNTVLLAIGRDSCTRKIGL 370

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK+G+I VN+ EQT  P VYAIGD+++   ELTPVAIQAG+LL+RRL+    
Sbjct: 371 EKIGVKINEKSGKIPVNDVEQTNVPYVYAIGDILEGKLELTPVAIQAGKLLARRLFGGRL 430

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCGLSEE + E +  +++EVYH  F PLEW++A +      
Sbjct: 431 EKCDYINVPTTVFTPLEYGCCGLSEEKAIEVHKKENLEVYHTLFWPLEWTVAGRDN---N 487

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 488 TCYAKIICNKFDNERVVGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 541


>gb|EFW43678.1| thioredoxin reductase 3 [Capsaspora owczarzaki ATCC 30864]
          Length = 500

 Score =  456 bits (1173), Expect = e-126
 Identities = 245/477 (51%), Positives = 316/477 (66%), Gaps = 21/477 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+V+GGGSGGLA SK+AA  GK+VCVLD+VKPSP G++WGLGGTCVNVGCIPKKLM
Sbjct: 10  YDYDLIVVGGGSGGLALSKQAAKLGKRVCVLDFVKPSPQGSTWGLGGTCVNVGCIPKKLM 69

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+GE +  D   FGW V   N +    DW +LV  V            V LR   V
Sbjct: 70  HQACLLGEAI-EDAEKFGWEVEKANIK---HDWSKLVMGVSDHIGGLNFAYRVSLRENNV 125

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G F D HT++    K+    +T  H V+AVGGRP+     G  EL ++SDD+F 
Sbjct: 126 TYLNAYGVFKDAHTIECTDKKRKVTTLTAEHFVLAVGGRPKYPDIPGARELGITSDDMFS 185

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL G+GY   VM RSI LRGFDQ  A +I  YM  + 
Sbjct: 186 LPY-APGKTLVVGASYVALECAGFLTGLGYDTTVMARSIFLRGFDQQCAEQIAAYMS-EH 243

Query: 241 GIEFIRKTVPQSITKLD------SGQLLVKWITEDGDCFE---ETFDTVLNATGRDPDVA 291
           G +F+R+ VP S+ +++      +G+  ++   EDG   E   + FDTVL A GR+   +
Sbjct: 244 GTKFLRRCVPLSLERIEPEADSATGRHRIRVTWEDGLANEPGSDVFDTVLFAIGREAVTS 303

Query: 292 KLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYN 350
            +GL+  G+K N  +G++    EQT+ PNV+AIGDVI+  PELTPVAIQAGRLL++RLY 
Sbjct: 304 TIGLEALGLKAN-ASGKVDAPLEQTSVPNVFAIGDVINGRPELTPVAIQAGRLLAKRLYG 362

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
             T QMDY  I T VFTP+EYGC G++EED+   Y ++++EV+H+ F PLEW++A +   
Sbjct: 363 GATTQMDYANIPTTVFTPLEYGCIGMAEEDAIALYKEENIEVFHQYFQPLEWTVAHR--- 419

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            A +CY K++C+K  N  V+G H LGPNAGE+TQ  G+A +LG T D    TVGIHP
Sbjct: 420 PASTCYCKLICNKLDNMRVIGLHILGPNAGEITQGYGVAFRLGATKDDFDMTVGIHP 476


>emb|CBK24910.2| unnamed protein product [Blastocystis hominis]
 emb|CBK23629.2| unnamed protein product [Blastocystis hominis]
          Length = 497

 Score =  456 bits (1172), Expect = e-126
 Identities = 249/476 (52%), Positives = 317/476 (66%), Gaps = 26/476 (5%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLA SKEAA  G  V + DYVKPSP G++WGLGGTCVNVGCIPKKL
Sbjct: 15  TYDYDLIVIGGGSGGLAASKEAADLGATVALFDYVKPSPQGSTWGLGGTCVNVGCIPKKL 74

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+++IGE +  D +SFGW+V  V+       W  LV NV            V L SK 
Sbjct: 75  MHQAAIIGEFV-RDASSFGWDVPEVH-----HHWNTLVDNVQDYIRGLNYNYRVSLMSKH 128

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEI-TTRHVVIAVGGRPRQLACLGGELAVSSDDIF 179
           V Y N L    D HT++      G K I T R +++AVGGRP +L C G ELAV+SDD+F
Sbjct: 129 VTYYNQLAYVKDAHTVE-GTDVFGDKHIYTCRRIIVAVGGRPNKLGCPGEELAVTSDDLF 187

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            M    P KTL+VGAS++ALECAGFL  +G+ V VMVRSILLRGFDQ+ A+KIG++M+ +
Sbjct: 188 -MLDHPPKKTLLVGASFIALECAGFLHHLGFDVTVMVRSILLRGFDQECANKIGDFMK-E 245

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCF-------EETFDTVLNATGRDPDVAK 292
            GI F+  TVP  + +L +G++LVK+    G  F       EE FDTV++  GR  D  +
Sbjct: 246 EGIHFLHNTVPTELQRLPNGRILVKY---QGSGFANSELRGEEEFDTVVSCIGRYADTER 302

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNE 351
           LGLD+ GVK   + G+I    EQT+ PN+Y IGDV+    ELTPVAIQ G+LL+RRLY  
Sbjct: 303 LGLDQLGVK--TRRGKILSVQEQTSVPNIYGIGDVLYGKQELTPVAIQTGKLLARRLYGG 360

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            +VQMDY+ +   VFTP+EYG CGL+EE + E +G+D+VEVY   F PLEW ++   R  
Sbjct: 361 SSVQMDYENVPMTVFTPLEYGNCGLTEEAALERFGEDNVEVYVSQFTPLEWQISPHRR-- 418

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            E C+ K++  K  +  +LGFH L PNAGE+TQ  GLA +   TY  L+D VGIHP
Sbjct: 419 KEVCFAKLI-TKRDDGLILGFHILSPNAGEITQGFGLAFQTKATYQNLMDLVGIHP 473


>ref|NP_001171641.1| thioredoxin reductase 3 isoform 1 [Rattus norvegicus]
          Length = 652

 Score =  456 bits (1172), Expect = e-126
 Identities = 249/474 (52%), Positives = 316/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDL+VIGGGSGGL+C+KEAA+ GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 163 THDYDLIVIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 222

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  L  D   +GW+    N QV   +W+ +   +            V LR K 
Sbjct: 223 MHQAALLGHAL-QDARKYGWD---YNQQV-KHNWETMREAIQNHIGSLNWGYRVTLREKG 277

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 278 VTYVNSFGEFVELHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLF 337

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TL+VGASYV LECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G Y+E Q
Sbjct: 338 SLPYC-PGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-Q 395

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F RK  P  + +L+ G      +V   TE  +  E T++TVL A GRD    K+GL
Sbjct: 396 QGVKFQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGL 455

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK G+I VN+ EQT  P+VYAIGDV++  PELTPVAIQAG+LL+RRL+    
Sbjct: 456 EKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISL 515

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 516 EKCDYINVPTTVFTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDN---N 572

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N+ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 573 TCYAKIICNKFDNDRVIGFHLLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 626


>ref|NP_001100079.2| thioredoxin reductase 3 isoform 2 [Rattus norvegicus]
          Length = 615

 Score =  456 bits (1172), Expect = e-126
 Identities = 249/474 (52%), Positives = 316/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDL+VIGGGSGGL+C+KEAA+ GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 126 THDYDLIVIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 185

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  L  D   +GW+    N QV   +W+ +   +            V LR K 
Sbjct: 186 MHQAALLGHAL-QDARKYGWD---YNQQV-KHNWETMREAIQNHIGSLNWGYRVTLREKG 240

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 241 VTYVNSFGEFVELHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLF 300

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TL+VGASYV LECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G Y+E Q
Sbjct: 301 SLPYC-PGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-Q 358

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F RK  P  + +L+ G      +V   TE  +  E T++TVL A GRD    K+GL
Sbjct: 359 QGVKFQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGL 418

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK G+I VN+ EQT  P+VYAIGDV++  PELTPVAIQAG+LL+RRL+    
Sbjct: 419 EKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISL 478

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 479 EKCDYINVPTTVFTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDN---N 535

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N+ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 536 TCYAKIICNKFDNDRVIGFHLLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 589


>ref|XP_002596165.1| hypothetical protein BRAFLDRAFT_203192 [Branchiostoma floridae]
 gb|EEN52177.1| hypothetical protein BRAFLDRAFT_203192 [Branchiostoma floridae]
          Length = 487

 Score =  456 bits (1172), Expect = e-126
 Identities = 238/471 (50%), Positives = 313/471 (66%), Gaps = 15/471 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLACSKEAA  G +V VLDYV PSP G+ WGLGG CVNVGCIPKKLM
Sbjct: 3   HDYDLVVVGGGSGGLACSKEAAQLGARVLVLDYVDPSPQGSRWGLGGCCVNVGCIPKKLM 62

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           H ++L+G  +  D   +GWN        PT DW  L + V            V+L+ KQV
Sbjct: 63  HHAALLGHAVQ-DSKKYGWNAHVD----PTIDWTTLTTVVQQHVKSLNWGHRVQLKDKQV 117

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y+N  GS +DPHT+++       K +T  ++V+AVGGRP+     G  E A++SDD+F 
Sbjct: 118 DYQNAKGSLLDPHTVRVVSANGKEKTVTASNIVLAVGGRPKYPDIPGAMEHAITSDDLF- 176

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           M +K PGKTLV+GASYV+LECAGFL G+G+   VM+RSI LRGFD+ MA  + ++ME  S
Sbjct: 177 MLEKPPGKTLVIGASYVSLECAGFLTGLGFDTTVMIRSIPLRGFDRQMADLVTDHME-GS 235

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           G  F+R+ VP +I K DSGQL V W    G   + TFDTV+ A GR  +   LGLD  GV
Sbjct: 236 GTRFLRQHVPSAIDKTDSGQLQVTWRDGSGQEGQGTFDTVMMAVGRFANTGTLGLDTVGV 295

Query: 301 KLNEKTGRI---WVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
           +   ++G++     N EQ++ P+++AIGD++   PELTPVAI+AGRLL+ RL+      M
Sbjct: 296 EWYSESGKVIGREENPEQSSVPHIFAIGDILHGRPELTPVAIKAGRLLAHRLFAATREHM 355

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DYDK+ T VFTP+EYG  GLSEE + E +G D VE+YH  + PLE+ + E+    A  CY
Sbjct: 356 DYDKVPTTVFTPLEYGSVGLSEEAALERFGPDQVEIYHAFYKPLEYYIPERD---ASQCY 412

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +K VC +  +  ++G H+LGPNAGEVTQ   +A++ G TY QL  +VGIHP
Sbjct: 413 IKAVCKRDGDQEIVGLHFLGPNAGEVTQGFAVALRSGLTYQQLASSVGIHP 463


>ref|XP_002108982.1| hypothetical protein TRIADDRAFT_19325 [Trichoplax adhaerens]
 gb|EDV29780.1| hypothetical protein TRIADDRAFT_19325 [Trichoplax adhaerens]
          Length = 489

 Score =  456 bits (1172), Expect = e-126
 Identities = 250/473 (52%), Positives = 320/473 (67%), Gaps = 19/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+V+GGGSGGLACSKEAA  G  V +LD+VKP+P G SWGLGGTCVNVGCIPKKLM
Sbjct: 5   YSYDLIVVGGGSGGLACSKEAAEQGLTVALLDFVKPTPLGCSWGLGGTCVNVGCIPKKLM 64

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE +H D + +GW +     +  +  W+++  NV            V+LR ++V
Sbjct: 65  HQASLLGESIH-DASHYGWEIN----ENCSHSWEKMKDNVQNHIGSINFGYRVQLRDRKV 119

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           KY N  G+ VDPHT+K    +     +T ++ VI+ G RPR     G  E  V+SDD+F 
Sbjct: 120 KYLNAYGTLVDPHTIKAVDRRGKETLLTAKNFVISSGCRPRYPDIPGAKEHCVTSDDLFS 179

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           + +K PGKTLV+GASYVALECAGFL G+G  V VMVRSILLRGFDQDMA ++G+YM+   
Sbjct: 180 L-EKCPGKTLVIGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQDMAERVGKYMK-DI 237

Query: 241 GIEFIRKTVP---QSITKLDSGQLL-VKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
           GI+FIR  VP   ++IT  D  ++L V + + ++G+  ++ FDTVL A GRDP    +GL
Sbjct: 238 GIKFIRPAVPLSVEAITMNDGKKVLNVNYTMLDNGNKAQDKFDTVLLAIGRDPCTVNIGL 297

Query: 296 DEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTV 354
           D AGV + EK G I   NEQT  P++Y IGD++ D PELTPVAI AGRLL++RL    T 
Sbjct: 298 DNAGVVV-EKNGYIKTVNEQTNVPSIYGIGDILYDKPELTPVAIHAGRLLAKRLSGVSTQ 356

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           Q DYD I T +FTP+EY CCGLSEE + E+ GDD VEVYH  F+PLEW++  +      S
Sbjct: 357 QCDYDSIPTTIFTPLEYSCCGLSEEVAIEKLGDD-VEVYHAQFMPLEWTIPHRDE---NS 412

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K++C+K     V+G H LGPN+GEV Q    AMK G T     DTVGIHP
Sbjct: 413 CYLKLICNKRDQERVIGIHILGPNSGEVMQGFATAMKCGATKAHFDDTVGIHP 465


>ref|XP_001377333.1| PREDICTED: similar to TXNRD3 protein [Monodelphis domestica]
          Length = 721

 Score =  455 bits (1170), Expect = e-126
 Identities = 245/474 (51%), Positives = 315/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDL+VIGGGSGGLACSKEAA++GKKV VLDYV P+P G SWGLGGTCVNVGCIPKKL
Sbjct: 234 TYEYDLIVIGGGSGGLACSKEAANWGKKVMVLDYVTPTPLGKSWGLGGTCVNVGCIPKKL 293

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       +    +W+ +   +            V LR K 
Sbjct: 294 MHQAALLGQAL-KDSRKFGWEY----EENVKHNWETMTEAIQNYIGSLNWGYRVSLREKS 348

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ HT+K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 349 VSYINSYGEFVEHHTIKAINRKGQETFYTAERFVIATGERPRYLGIPGDKEYCITSDDLF 408

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTL++GASYVALEC GFL G+G  V +MVRSILLRGFDQ++A KIG YMEM 
Sbjct: 409 SLPYC-PGKTLIIGASYVALECGGFLAGIGLDVTIMVRSILLRGFDQEIAEKIGSYMEMH 467

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G+ F+R+ +P +I +L+ G      +V   TE  +  E  ++TVL A GR+    K+GL
Sbjct: 468 -GVTFLRQYIPVTIQQLEEGTPGRLKVVAKSTEGSETIEGEYNTVLIAIGRESCTRKIGL 526

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NE TG+I VN+ EQT    VYA+GDV+ D  ELTPVAIQAG+LL+RRLY    
Sbjct: 527 EKIGVKINENTGKIPVNDEEQTNVSYVYAVGDVLEDKLELTPVAIQAGKLLARRLYGGQL 586

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCG SEE ++E +  D++EV+H  F PLEW++A +     +
Sbjct: 587 EKCDYINVPTTVFTPLEYGCCGFSEEKARELFNKDNIEVFHTYFWPLEWTIAGREN---D 643

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +C+ K++C+K  NN V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 644 TCFGKIICNKRDNNRVIGFHVLGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 697


>ref|NP_001116163.1| thioredoxin reductase 2, mitochondrial [Gallus gallus]
          Length = 518

 Score =  454 bits (1169), Expect = e-125
 Identities = 246/476 (51%), Positives = 322/476 (67%), Gaps = 23/476 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           +YDL+VIGGGSGGLAC+KEAA FGK V VLDYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 29  EYDLLVIGGGSGGLACAKEAAQFGKNVAVLDYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 88

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G  L  D   +GW+V          +W  +   V            V+L+ K+VK
Sbjct: 89  QAALLGGAL-KDAQHYGWSV----AHPVHHNWSVMAQAVQNYVKSLNWGHRVQLQDKKVK 143

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+ GSF D HT  +    KG KE  +T   +VIA GGRP+    + G  E  ++SDD+
Sbjct: 144 YFNMKGSFSDSHT--VCGIAKGGKETTLTAEKIVIATGGRPKYPTHITGALEYGITSDDL 201

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMG----YAVKVMVRSILLRGFDQDMASKIGE 234
           FW+K   PGKTLVVGASYV+LECAGFL G+G      +++++RSI LRGFDQ MAS + E
Sbjct: 202 FWLKD-SPGKTLVVGASYVSLECAGFLTGIGLDTTVIMRIIMRSIPLRGFDQQMASLVTE 260

Query: 235 YMEMQSGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKL 293
           +ME   G +F++K VP  + KL+S +L V W  TE G    ++FDTV+ A GR PD+  L
Sbjct: 261 HME-SYGTKFLKKCVPAKVEKLESSRLQVTWKNTELGTEETDSFDTVMWAVGRVPDIKTL 319

Query: 294 GLDEAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNE 351
            LD  GVK N +TG+I V+ +E T+ P++YAIGD+ +  PELTP AI AG+LL+RRL+  
Sbjct: 320 NLDSVGVKTNSETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLARRLFGH 379

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            +  MDYD + T VFTP+EYGC GLSEE + + YG D+VEV+H  + PLE+++AE+    
Sbjct: 380 SSELMDYDNVPTTVFTPLEYGCVGLSEEKAVQCYGSDNVEVFHAYYKPLEFTVAERD--- 436

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           A  CY+K+VC + R   +LG H++GPNAGEV Q   L +K G TY QL+ T+GIHP
Sbjct: 437 AAQCYIKMVCLREREQRILGLHFIGPNAGEVIQGFALGIKCGATYPQLMKTIGIHP 492


>ref|XP_797733.2| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus]
 ref|XP_001181272.1| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus]
          Length = 490

 Score =  454 bits (1169), Expect = e-125
 Identities = 230/470 (48%), Positives = 317/470 (67%), Gaps = 14/470 (2%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL VIGGGSGGLAC+KEAA F KKV VLDYV PSP GT WGLGGTCVNVGCIPKKL
Sbjct: 8   SYDYDLAVIGGGSGGLACAKEAAGFDKKVIVLDYVDPSPQGTKWGLGGTCVNVGCIPKKL 67

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           +H +SL+ E + HD   +GW V    G      W  L+  +            V+L+ K 
Sbjct: 68  LHHASLLRESM-HDAKHYGWQVPDDIG----LSWSTLIGGIQGHVKSLNWGHRVQLQDKN 122

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V+Y N  GSF+D HT+K+        + +  ++V+A GGRP+    + G  E  ++SDDI
Sbjct: 123 VEYVNGKGSFIDEHTVKVKMKDGKETQFSAANIVLATGGRPKYPDKVPGAMEYGITSDDI 182

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +K   PG++LV+G SYVALECAGFL G+G+   VMVRSI LRGFDQ M+  + ++ME 
Sbjct: 183 FSLK-TPPGRSLVIGGSYVALECAGFLHGLGFPTTVMVRSICLRGFDQQMSRLVADHME- 240

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            SGI+F+ + VP+S+ K  +G L V+W ++ G      FDTV+ A GR+P+ A+LGLD  
Sbjct: 241 ASGIQFLWQQVPESVAKNQNGSLNVRWRSDQGQEGHGEFDTVMFAVGREPETAQLGLDNT 300

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV+L+E  G++  +NEQ++ P+++AIGD++++  ELTPVAI+ G+LL++RL+ +GT  M+
Sbjct: 301 GVQLSE-GGKVMGSNEQSSVPHIHAIGDILESGIELTPVAIRTGKLLAQRLFGQGTEHMN 359

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYV 417
           Y+++ T VFTP+EY C GLSEE + E YG+D +EVYH  + PLE+ +  +    AE CY+
Sbjct: 360 YEQVATTVFTPLEYSCVGLSEETATERYGEDHIEVYHAFYKPLEYVVPNK---PAEQCYI 416

Query: 418 KVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           K +C +  +  +LG H  GP AGE+ Q   LA+K+G TY  L  T+GIHP
Sbjct: 417 KAICLRDGDQRILGLHITGPGAGEIMQGFALAVKMGATYQHLSSTIGIHP 466


>ref|NP_001171529.1| thioredoxin reductase 3 isoform 1 [Mus musculus]
          Length = 652

 Score =  454 bits (1168), Expect = e-125
 Identities = 248/474 (52%), Positives = 313/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDL++IGGGSGGL+C+KEAA+ GKKV VLD+V PSP GT+WGLGGTCVNVGCIPKKL
Sbjct: 163 AHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKL 222

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  L  D   +GW     N QV   +W+ +   +            V LR K 
Sbjct: 223 MHQAALLGHAL-QDAKKYGW---EYNQQV-KHNWEAMTEAIQSHIGSLNWGYRVTLREKG 277

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FVD H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 278 VTYVNSFGEFVDLHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLF 337

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TLVVGASYV LECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G Y+E Q
Sbjct: 338 SLPYC-PGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-Q 395

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F RK  P  + +L+ G      +V   TE  +  E  ++TVL A GRD    K+GL
Sbjct: 396 QGVKFQRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGL 455

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK G+I VN+ EQT  P+VYAIGD++D  PELTPVAIQAG+LL+RRL+    
Sbjct: 456 EKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSL 515

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  I T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 516 EKCDYINIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---N 572

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGE+TQ    AMK G T   L DT+GIHP
Sbjct: 573 TCYAKIICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHP 626


>ref|XP_002713123.1| PREDICTED: Thioredoxin reductase 3-like, partial [Oryctolagus
           cuniculus]
          Length = 673

 Score =  454 bits (1168), Expect = e-125
 Identities = 243/474 (51%), Positives = 316/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDL+VIGGGSGGL+C+KEAA  G+KV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 186 AYEYDLIVIGGGSGGLSCAKEAAILGRKVMVLDFVVPSPRGTSWGLGGTCVNVGCIPKKL 245

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       Q    +W+ +   +            + LR + 
Sbjct: 246 MHQAALLGQAL-RDSRKFGWEY----SQQVKHNWETMTEAIQNHIGSLNWGYRLSLRERG 300

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ HT+K  + K      T+ + VIA G RPR L   G  E  ++SDD+F
Sbjct: 301 VTYVNSYGEFVEHHTVKATNRKGQETYYTSANFVIATGERPRYLGIPGDKEFCITSDDLF 360

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ++A K+G YM+ Q
Sbjct: 361 SLPYC-PGKTLVVGASYVALECAGFLAGLGLDVTVMVRSILLRGFDQEVAEKVGSYMQ-Q 418

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F+RK VP  + +L+ G      +    TE  +  E  ++TVL A GRD     +GL
Sbjct: 419 HGVKFLRKFVPVMVQQLEKGSPGKLKVTAKSTEGPETIEGVYNTVLLAIGRDSCTRNIGL 478

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GV++NEK G+I VN+ EQT  P VYA+GDV++  PELTPVAIQAG+LL+RRL+   +
Sbjct: 479 EKIGVRINEKNGKIPVNDVEQTNVPYVYAVGDVLEGKPELTPVAIQAGKLLARRLHGASS 538

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  I T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 539 EKCDYFSIPTTVFTPLEYGCCGLSEEKATELYMKENLEVYHTLFWPLEWTVAGRDN---N 595

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K   + V+GFH LGPNAGE+TQ    AMK G T   L +T+GIHP
Sbjct: 596 TCYAKIICNKLDQDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDETIGIHP 649


>sp|Q99MD6|TRXR3_MOUSE RecName: Full=Thioredoxin reductase 3; AltName: Full=Thioredoxin
           and glutathione reductase; AltName: Full=Thioredoxin
           reductase TR2
          Length = 697

 Score =  454 bits (1168), Expect = e-125
 Identities = 248/474 (52%), Positives = 313/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDL++IGGGSGGL+C+KEAA+ GKKV VLD+V PSP GT+WGLGGTCVNVGCIPKKL
Sbjct: 208 AHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKL 267

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  L  D   +GW     N QV   +W+ +   +            V LR K 
Sbjct: 268 MHQAALLGHAL-QDAKKYGW---EYNQQV-KHNWEAMTEAIQSHIGSLNWGYRVTLREKG 322

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FVD H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 323 VTYVNSFGEFVDLHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLF 382

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TLVVGASYV LECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G Y+E Q
Sbjct: 383 SLPYC-PGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-Q 440

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F RK  P  + +L+ G      +V   TE  +  E  ++TVL A GRD    K+GL
Sbjct: 441 QGVKFQRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGL 500

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK G+I VN+ EQT  P+VYAIGD++D  PELTPVAIQAG+LL+RRL+    
Sbjct: 501 EKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSL 560

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  I T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 561 EKCDYINIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---N 617

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGE+TQ    AMK G T   L DT+GIHP
Sbjct: 618 TCYAKIICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHP 671


>ref|NP_694802.2| thioredoxin reductase 3 isoform 2 [Mus musculus]
 gb|AAK31172.1|AF349659_1 thioredoxin and glutathione reductase [Mus musculus]
          Length = 615

 Score =  454 bits (1168), Expect = e-125
 Identities = 248/474 (52%), Positives = 313/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDL++IGGGSGGL+C+KEAA+ GKKV VLD+V PSP GT+WGLGGTCVNVGCIPKKL
Sbjct: 126 AHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKL 185

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  L  D   +GW     N QV   +W+ +   +            V LR K 
Sbjct: 186 MHQAALLGHAL-QDAKKYGW---EYNQQV-KHNWEAMTEAIQSHIGSLNWGYRVTLREKG 240

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FVD H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 241 VTYVNSFGEFVDLHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLF 300

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TLVVGASYV LECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G Y+E Q
Sbjct: 301 SLPYC-PGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-Q 358

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F RK  P  + +L+ G      +V   TE  +  E  ++TVL A GRD    K+GL
Sbjct: 359 QGVKFQRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGL 418

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK G+I VN+ EQT  P+VYAIGD++D  PELTPVAIQAG+LL+RRL+    
Sbjct: 419 EKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSL 478

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  I T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 479 EKCDYINIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---N 535

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGE+TQ    AMK G T   L DT+GIHP
Sbjct: 536 TCYAKIICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHP 589


>dbj|BAB28419.1| unnamed protein product [Mus musculus]
 dbj|BAC37890.1| unnamed protein product [Mus musculus]
 gb|AAH76605.1| Thioredoxin reductase 3 [Mus musculus]
 gb|EDK99269.1| thioredoxin reductase 3 [Mus musculus]
          Length = 613

 Score =  454 bits (1168), Expect = e-125
 Identities = 248/474 (52%), Positives = 313/474 (66%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDL++IGGGSGGL+C+KEAA+ GKKV VLD+V PSP GT+WGLGGTCVNVGCIPKKL
Sbjct: 126 AHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKL 185

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  L  D   +GW     N QV   +W+ +   +            V LR K 
Sbjct: 186 MHQAALLGHAL-QDAKKYGW---EYNQQV-KHNWEAMTEAIQSHIGSLNWGYRVTLREKG 240

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FVD H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 241 VTYVNSFGEFVDLHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLF 300

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TLVVGASYV LECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G Y+E Q
Sbjct: 301 SLPYC-PGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLE-Q 358

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++F RK  P  + +L+ G      +V   TE  +  E  ++TVL A GRD    K+GL
Sbjct: 359 QGVKFQRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGL 418

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK G+I VN+ EQT  P+VYAIGD++D  PELTPVAIQAG+LL+RRL+    
Sbjct: 419 EKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSL 478

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  I T VFTP+EYGCCGLSEE + E Y  +++EVYH  F PLEW++A +      
Sbjct: 479 EKCDYINIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDN---N 535

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N  V+GFH LGPNAGE+TQ    AMK G T   L DT+GIHP
Sbjct: 536 TCYAKIICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHP 589


>ref|XP_001991610.1| GH12753 [Drosophila grimshawi]
 gb|EDW00235.1| GH12753 [Drosophila grimshawi]
          Length = 596

 Score =  454 bits (1167), Expect = e-125
 Identities = 251/471 (53%), Positives = 318/471 (67%), Gaps = 17/471 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDLVVIGGGSGGLAC+KEA + G +V  LDYVKP+P GT WG+GGTCVNVGCIPKKL
Sbjct: 113 SYDYDLVVIGGGSGGLACAKEAVANGARVACLDYVKPTPIGTKWGVGGTCVNVGCIPKKL 172

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + H+ A++GWNV          DWK+LVS+V            V+LR K+
Sbjct: 173 MHQASLLGEAV-HEAAAYGWNVDDKIKP----DWKKLVSSVQNHIKSVNWVTRVDLRDKK 227

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LGSFVDPHTL     K G + IT +  VIAVGGRPR     G  E  ++SDD+F
Sbjct: 228 VEYINGLGSFVDPHTLSA-KLKNGDRTITAQTFVIAVGGRPRYPNIPGAVEYGITSDDLF 286

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA+ +   ME +
Sbjct: 287 SL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAASME-E 344

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            GI F+R+TVP S+ K   G+LLVK+  TE G+   + FDTVL A GR   V  L L  A
Sbjct: 345 RGIPFLRRTVPLSVEKQPDGRLLVKYECTETGEIGSDVFDTVLWAVGRKGLVDDLNLPNA 404

Query: 299 GVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV  +    +I V+ +E T  P++YA+GD+I   PELTPVA+ AGRLL+RRLY +  ++M
Sbjct: 405 GVLAH--NDKIQVDCDEATNVPHIYAVGDIIHGKPELTPVAVLAGRLLARRLYADSDLRM 462

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY  + T VFTP+EY C GLSEED+ + +G D +EV+H  + P E+ + ++   +   CY
Sbjct: 463 DYADVATTVFTPLEYACVGLSEEDAVKAHGADEIEVFHGYYKPTEFFIPQK---SVRYCY 519

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           VK V  +  +  V G HYLGP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 520 VKAVAQRHGDQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHP 570


>ref|XP_002288115.1| thioredoxin reductase [Thalassiosira pseudonana CCMP1335]
 gb|EED95558.1| thioredoxin reductase [Thalassiosira pseudonana CCMP1335]
          Length = 503

 Score =  453 bits (1166), Expect = e-125
 Identities = 247/478 (51%), Positives = 312/478 (65%), Gaps = 22/478 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDL+V+GGGSGGLA SKEAA+ G +V VLDYVKPSP G++WGLGGTCVNVGCIPKKLM
Sbjct: 12  YEYDLLVLGGGSGGLAASKEAAAHGARVAVLDYVKPSPAGSTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGEILHHDCASFGWNVGSV-----------NGQVPTFDWKQLVSNVXXXXXXXXX 110
           H ++L+      D   +G NV              N   P   W  L +NV         
Sbjct: 72  HTAALLNYQQKVDQPHYGINVSESQTEEWMGMSQDNADAP-HSWGILKNNVQNHIRGLNF 130

Query: 111 XXXVELRSKQVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGE 170
              V+LR K+V Y N+LG F D HT++    K     IT    +IAVGGRP  L C GGE
Sbjct: 131 KYRVDLREKEVTYLNMLGKFKDAHTVETVDKKGNVGSITASRFLIAVGGRPSPLDCEGGE 190

Query: 171 LAVSSDDIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMAS 230
           LA+SSDD+F + + +PGK L VGASY++LECAGFLKG+G  V V VRSILLRGFD++ A 
Sbjct: 191 LAISSDDVFSL-ENDPGKVLCVGASYISLECAGFLKGIGKDVTVAVRSILLRGFDRECAD 249

Query: 231 KIGEYMEMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDV 290
            IGE+M    GI F  + VP+ + K + G++ V +   +GD   E +DTVL A GR  D 
Sbjct: 250 LIGEHMR-HEGIVFKEEVVPKKLVKTEGGRIAVTF--SNGDV--EEYDTVLAAIGRTGDT 304

Query: 291 AKLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRLY 349
           +KLGL+  G+ +N K  +I    EQT TPN+Y IGDV+D  PELTPVAI AG++LSRRL+
Sbjct: 305 SKLGLENVGIDVNPKNAKIPAKLEQTCTPNIYVIGDVMDGCPELTPVAIHAGKMLSRRLF 364

Query: 350 NEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR 409
              T  MDY  +CT VFTP+EYG  G SE+D+  E+G ++VEVYHK F+PLEWSL+  +R
Sbjct: 365 AGSTAPMDYRNVCTTVFTPLEYGTVGYSEDDAIAEFGKENVEVYHKYFIPLEWSLS-PSR 423

Query: 410 IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             ++     +V   TR   VLG HYLGPNAGEV Q  G AMKLG  ++ + +TVGIHP
Sbjct: 424 SESQGFCKAIVYKATRK--VLGLHYLGPNAGEVMQGFGTAMKLGCKFEDITETVGIHP 479


>ref|XP_002594765.1| hypothetical protein BRAFLDRAFT_122807 [Branchiostoma floridae]
 gb|EEN50776.1| hypothetical protein BRAFLDRAFT_122807 [Branchiostoma floridae]
          Length = 596

 Score =  452 bits (1163), Expect = e-125
 Identities = 243/472 (51%), Positives = 309/472 (65%), Gaps = 15/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLA SKEA  FGKKV V D+VKPSP GT+WGLGGTCVNVGCIPKKL
Sbjct: 111 AYDYDLIVIGGGSGGLAASKEAGKFGKKVLVCDFVKPSPIGTTWGLGGTCVNVGCIPKKL 170

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  +  D   FGW V     +    +W  +   +            V LR K 
Sbjct: 171 MHQAALLGHSI-EDSRKFGWEV----SEEVKHNWHTMKEAIQNYIGSLNWGYRVALRDKG 225

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           VKYEN    FVDPHT+K  + +      T    ++AVG RPR     G  E  ++SDD+F
Sbjct: 226 VKYENAYAEFVDPHTIKTVNRRGKENTATAERFLVAVGMRPRYPDIPGAKEYGITSDDLF 285

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLV+GASYVALECAGFL+G+G    VMVRSILLRGFDQ MA K+G YME +
Sbjct: 286 SLPYC-PGKTLVIGASYVALECAGFLRGIGLDTTVMVRSILLRGFDQQMADKVGAYME-K 343

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWIT--EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
            G++FIR  VP  + +L+ GQ     +T  +DG       +T+L   GRD     + L++
Sbjct: 344 GGMKFIRGCVPTKVERLEEGQPGKLRVTGMQDGKEVVWEGNTILFGIGRDACTEGIHLEK 403

Query: 298 AGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV+ N K G+I+ N+ EQT  P++YAIGDV++   ELTPVAIQAG+LL++RLY     +
Sbjct: 404 AGVQFNTKNGKIYGNDVEQTNQPHIYAIGDVLEGKLELTPVAIQAGKLLAQRLYGGAQTK 463

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
            DY  + T VFTP+EYG CGLSEED+  +YG+D++EVYH NF PLEW++          C
Sbjct: 464 TDYINVPTTVFTPLEYGACGLSEEDAIAKYGEDNIEVYHSNFQPLEWTVPGHD---VNDC 520

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y K++C++  N  V+GFH LGPNAGE+TQ  G AMK G T  QL  T+GIHP
Sbjct: 521 YAKILCNRQDNERVVGFHVLGPNAGEITQGYGAAMKCGMTKAQLDTTIGIHP 572


>ref|XP_002056889.1| GJ16646 [Drosophila virilis]
 gb|EDW62375.1| GJ16646 [Drosophila virilis]
          Length = 556

 Score =  452 bits (1163), Expect = e-125
 Identities = 249/471 (52%), Positives = 319/471 (67%), Gaps = 17/471 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGL+C+KEA + G +V  LD+VKP+P GT WG+GGTCVNVGCIPKKL
Sbjct: 73  NYDYDLVVIGGGSGGLSCAKEAVAHGARVACLDFVKPTPIGTKWGVGGTCVNVGCIPKKL 132

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + H+ A++GWNV          DW +LVS+V            V+LR K+
Sbjct: 133 MHQASLLGEAV-HEAAAYGWNVDDKIKP----DWNKLVSSVQNHIKSVNWVTRVDLRDKK 187

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LGSFVDPHTL     K G + IT +  VIAVGGRPR     G  E  ++SDD+F
Sbjct: 188 VEYINGLGSFVDPHTLSA-KLKSGDRTITAQTFVIAVGGRPRYPNIPGAVEYGITSDDLF 246

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA+ +   ME +
Sbjct: 247 SL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAASME-E 304

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            GI F+RKTVP S+ K   G+LLVK+  TE G+   + FDTVL A GR   V  L L  A
Sbjct: 305 RGIPFLRKTVPLSVEKQSDGRLLVKYENTETGEIDSDVFDTVLWAIGRKGLVEDLNLHNA 364

Query: 299 GVKLNEKTGRIWVNNEQTT-TPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV  ++   +I V+ E+TT  P++YA+GD+I   PELTPVA+ AGRLL+RRLY +  ++M
Sbjct: 365 GVLTHK--DKIQVDCEETTNVPHIYAVGDIIYGKPELTPVAVLAGRLLARRLYADSDLRM 422

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY  + T VFTP+EY C GLSEED+ + YG + +EV+H  + P E+ + ++   +   CY
Sbjct: 423 DYADVATTVFTPLEYACVGLSEEDAVKTYGAEEIEVFHGYYKPTEFFIPQK---SVRYCY 479

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           VK V  ++    V G HYLGP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 480 VKAVAQRSGEQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHP 530


>gb|AAD25167.1|AF044212_1 thioredoxin reductase [Homo sapiens]
          Length = 521

 Score =  452 bits (1163), Expect = e-125
 Identities = 245/474 (51%), Positives = 319/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 36  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 95

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 96  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 150

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 151 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 208

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 209 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 266

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 267 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 324

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP+AI AGRLL +RL+   +
Sbjct: 325 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSS 384

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 385 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 441

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 442 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 495


>ref|NP_006431.2| thioredoxin reductase 2, mitochondrial precursor [Homo sapiens]
 sp|Q9NNW7|TRXR2_HUMAN RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Selenoprotein Z; Short=SelZ; AltName: Full=TR-beta;
           AltName: Full=Thioredoxin reductase TR3; Flags:
           Precursor
 gb|AAD51324.1|AF171054_1 thioredoxin reductase TR3 [Homo sapiens]
          Length = 524

 Score =  452 bits (1163), Expect = e-125
 Identities = 245/474 (51%), Positives = 319/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 99  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 153

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 154 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 211

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 212 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 269

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 270 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 327

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP+AI AGRLL +RL+   +
Sbjct: 328 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSS 387

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 388 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 444

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 445 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 498


>gb|AAD19597.1| thioredoxin reductase [Homo sapiens]
          Length = 524

 Score =  452 bits (1162), Expect = e-125
 Identities = 245/474 (51%), Positives = 319/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 99  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 153

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 154 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 211

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 212 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 269

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 270 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 327

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP+AI AGRLL +RL+   +
Sbjct: 328 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSS 387

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 388 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 444

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 445 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 498


>ref|XP_850181.1| PREDICTED: similar to thioredoxin reductase 2 isoform 1 precursor
           [Canis familiaris]
          Length = 509

 Score =  452 bits (1162), Expect = e-125
 Identities = 246/472 (52%), Positives = 314/472 (66%), Gaps = 19/472 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           +YDL+VIGGGSGGLAC+KEAA  GKKV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 26  NYDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 85

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D   +GW+V     Q    DW+ +   V            V+L+ ++V 
Sbjct: 86  QAALLGSMI-RDAPHYGWDV----AQPVLHDWRTMAEAVQNHVKSLNWGHRVQLQDRKVT 140

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y NV  SFV+ HT  +    KG KE  ++  H+VIA GGRPR    + G  E  ++SDDI
Sbjct: 141 YFNVKASFVNEHT--VCGVAKGGKETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDI 198

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + EYM  
Sbjct: 199 FWLKE-SPGKTLVVGASYVALECAGFLTGLGLDTTIMIRSIPLRGFDQQMSSLVTEYMAS 257

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           Q G  F+R   P  + +L  GQL V W     G     TFDTVL A GR P+   L L++
Sbjct: 258 Q-GTRFLRGCTPSRVRRLPDGQLQVTWENLTSGKEDVGTFDTVLWAIGRIPETKSLNLEK 316

Query: 298 AGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV  N  + +I VN  E T+ P++YAIGDV +  PELTP AI AGRLL++RL  + +  
Sbjct: 317 AGVNTNPNSQKILVNAQEATSIPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLCGQASDV 376

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDYD + T VFTP+EYGC GLSEE++   +G++ VEVYH  + PLE+++AE+    A  C
Sbjct: 377 MDYDNVPTTVFTPLEYGCVGLSEEEAVTRHGEEHVEVYHAYYKPLEFTVAERD---ASQC 433

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           YVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 434 YVKMVCLRKPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 485


>gb|EFB13457.1| hypothetical protein PANDA_003518 [Ailuropoda melanoleuca]
          Length = 539

 Score =  451 bits (1161), Expect = e-125
 Identities = 240/476 (50%), Positives = 315/476 (66%), Gaps = 19/476 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEA--ASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPK 58
           +YDYDL+++GGGSGGLA +K    + + KK+ VLD+V P+PHGT WGLGGTCVNVGCIPK
Sbjct: 70  AYDYDLIIVGGGSGGLAAAKARLLSKYDKKIMVLDFVTPTPHGTRWGLGGTCVNVGCIPK 129

Query: 59  KLMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRS 118
           KLMHQ++L+G+ L  D  ++GW+      +    DW ++   V            V LR 
Sbjct: 130 KLMHQAALLGQALR-DSRNYGWDTE----ETVKHDWNKMTEAVQNHIGSLNWGYRVALRE 184

Query: 119 KQVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDD 177
           K+V YEN  G FV PH +K  + K   K  +    +IA G RPR L   G  E  +SSDD
Sbjct: 185 KKVTYENAYGEFVGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDREYCISSDD 244

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           +F +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME
Sbjct: 245 LFSLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME 303

Query: 238 MQSGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKL 293
            + G++FI++ VP  + ++++G      +V   T   +  E  ++TVL A GRD    K+
Sbjct: 304 -EHGVKFIKQFVPIKVEQIEAGTPGRLRVVAKSTSSDETIEGEYNTVLLAIGRDACTRKI 362

Query: 294 GLDEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNE 351
           GL+  GVK+NEK G+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY  
Sbjct: 363 GLETVGVKINEKNGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYAG 422

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
             V+ DY+ + T VFTP+EYG CGLSEE + E +G++++EVYH  F PLEW++  +    
Sbjct: 423 SNVKCDYENVPTTVFTPLEYGACGLSEEKAVETFGEENIEVYHSFFWPLEWTIPSRDN-- 480

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              CY K++C+   N  V+GFH LGPNAGEVTQ    A+K G T  QL  T+GIHP
Sbjct: 481 -NKCYAKIICNIKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHP 535


>gb|ADH94550.1| thioredoxin reductase 1 [Apis cerana cerana]
 gb|ADH94551.1| thioredoxin reductase 1 [Apis cerana cerana]
          Length = 494

 Score =  451 bits (1160), Expect = e-124
 Identities = 240/467 (51%), Positives = 314/467 (67%), Gaps = 12/467 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA +FG KV VLD+V PSP G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 11  YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 70

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+GE + HD  S+GW +   + +    DW+ L + V            VELR+K+++Y
Sbjct: 71  AALLGESI-HDSVSYGWQL--PDPKTIKNDWQALRTAVQNHVKSVNWVTRVELRTKKIEY 127

Query: 124 ENVLGSFVDPHTLKLWHPKKG-TKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWM 181
            N LG F D HT+ L   K G  KE T ++++IAVGGRPR     G  E  ++SDDIF +
Sbjct: 128 FNALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSL 186

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
            +K PGKTL+VGA Y+ LECAGFL G+GY   VMVRSI+LRGFDQ MAS + + ME + G
Sbjct: 187 -EKAPGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRG 244

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVK 301
           I FI +  P  I K   G+LLV W+ +D    ++TFDTVL A GR P   +L  +  G+K
Sbjct: 245 IHFIYEAKPSKIEKQTDGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLK 304

Query: 302 LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
           L  +T +I   +EQT  PNVYA+GDV+   PELTPVAI AGRLL+RRL+   T QMDY  
Sbjct: 305 LVPETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVN 364

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           + T VF+P+EYGC GLSEE +   +GDD +E+YH  + P E+ + ++      +CY+KV+
Sbjct: 365 VATTVFSPLEYGCVGLSEEAAIAIHGDDKIEIYHAYYKPTEFFIPQKD---VSNCYLKVI 421

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             +  +  VLG H++GPNAGEV Q    A+K   T+ +L DTVGIHP
Sbjct: 422 AFRNGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHP 468


>gb|AAI17355.1| TXNRD2 protein [Homo sapiens]
 gb|ADR83199.1| Unknown protein [synthetic construct]
          Length = 492

 Score =  451 bits (1160), Expect = e-124
 Identities = 245/474 (51%), Positives = 318/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 69  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 123

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 124 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 181

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 182 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 239

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 240 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 297

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 298 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 357

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 358 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 414

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 415 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 468


>dbj|BAA77601.2| thioredoxin reductase II alpha [Homo sapiens]
          Length = 524

 Score =  451 bits (1160), Expect = e-124
 Identities = 245/474 (51%), Positives = 318/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 99  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 153

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 154 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 211

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 212 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 269

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 270 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 327

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 328 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 387

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 388 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 444

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 445 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 498


>dbj|BAA77602.2| thioredoxin reductase II beta [Homo sapiens]
          Length = 494

 Score =  451 bits (1160), Expect = e-124
 Identities = 245/474 (51%), Positives = 318/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 69  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 123

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 124 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 181

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 182 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 239

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 240 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 297

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 298 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 357

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 358 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 414

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 415 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 468


>ref|NP_001120487.1| thioredoxin reductase 2 [Xenopus (Silurana) tropicalis]
 gb|AAI61360.1| LOC100145605 protein [Xenopus (Silurana) tropicalis]
          Length = 502

 Score =  451 bits (1159), Expect = e-124
 Identities = 237/473 (50%), Positives = 318/473 (67%), Gaps = 19/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL+VIGGGSGGLAC+K+AA FGKKV V DYV+PSP GT WG+GGTCVNVGCIPKKLM
Sbjct: 18  HDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLM 77

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++LIG  L  D   +GW+  +        +W ++   V            ++L+ K+V
Sbjct: 78  HQAALIGSTL-KDAPHYGWDTPN----EIQHNWGKMAKAVQNYVKSLNWGHRIQLQDKKV 132

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDD 177
           KY N+  SFVD H ++     K  KE  +T  ++VIA GGRP+    + G  E  ++SDD
Sbjct: 133 KYFNMKASFVDEHCIR--GVTKAGKETLVTAENIVIATGGRPKYPTHVPGALEYGITSDD 190

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           +FW+K+  PGKTLVVGASYV+LECAGFL G+G     MVRSI LRGFDQ MA  + +YME
Sbjct: 191 LFWLKE-SPGKTLVVGASYVSLECAGFLTGIGLDTAAMVRSIPLRGFDQQMAYLVTDYME 249

Query: 238 MQSGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           +  G +F+ K  P ++ KL +G+L V W  TE G    + +DTV+ A GR  +   L L+
Sbjct: 250 LH-GTKFLWKCTPSNVEKLKNGKLEVTWKNTESGKEGADIYDTVMWAVGRAAETQYLNLE 308

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           + GV +   TG+I VN +E T+ P++YAIGD+ +  PELTP AI AG+LL+ RL++    
Sbjct: 309 KVGVDVKSDTGKIIVNASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLASRLFSGSAE 368

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDYD + T VFTP+EYGC G+SEED+KE YGDD++EV+H  + PLE+ +AE+       
Sbjct: 369 LMDYDSVPTTVFTPLEYGCVGISEEDAKERYGDDNIEVFHAFYKPLEFIVAERN---GSQ 425

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K++C +T++  +LG H+ GPNAGEV Q   L +K G TY QL+ TVGIHP
Sbjct: 426 CYIKIICLRTQDQRILGLHFTGPNAGEVIQGFALGIKCGATYHQLMRTVGIHP 478


>dbj|BAD92961.1| thioredoxin reductase 2 isoform 1 precursor variant [Homo sapiens]
          Length = 511

 Score =  451 bits (1159), Expect = e-124
 Identities = 245/474 (51%), Positives = 318/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 28  DYDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 87

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 88  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 142

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 143 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 200

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 201 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 258

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 259 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 316

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 317 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 376

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 377 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 433

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 434 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 487


>gb|AAG47635.1|AF201385_1 mitochondrial thioredoxin reductase [Homo sapiens]
          Length = 521

 Score =  451 bits (1159), Expect = e-124
 Identities = 245/474 (51%), Positives = 318/474 (67%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 38  DYDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 97

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 98  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 152

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 153 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 210

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 211 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 268

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 269 SHGTRFLRGCAPSRVKRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 326

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 327 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 386

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 387 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 443

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 444 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 497


>ref|XP_001354460.2| GA15270 [Drosophila pseudoobscura pseudoobscura]
 gb|EAL31513.2| GA15270 [Drosophila pseudoobscura pseudoobscura]
          Length = 490

 Score =  449 bits (1156), Expect = e-124
 Identities = 247/470 (52%), Positives = 316/470 (67%), Gaps = 15/470 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGS GLAC+KEA   G +V  LDYVKP+P GT WG+GGTCVNVGCIPKKL
Sbjct: 7   TYDYDLVVIGGGSAGLACAKEAVQNGARVACLDYVKPTPIGTKWGVGGTCVNVGCIPKKL 66

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + H+ A++GWNV          DW +LVS+V            V+LR K+
Sbjct: 67  MHQASLLGEAV-HEAAAYGWNVDDKIKP----DWSKLVSSVQNHIKSVNWVTRVDLRDKK 121

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LGSFVD HT+ +   K G + IT +  VIAVGGRPR     G  E  ++SDD+F
Sbjct: 122 VEYINGLGSFVDRHTM-VAKLKSGDRTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLF 180

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +   EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   M+ +
Sbjct: 181 SL-DHEPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVASSMD-E 238

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            GI F+RKTVP S+TK D+G+LLVK+  TE G+  E+T+DTVL A GR   V  L L  A
Sbjct: 239 RGIPFLRKTVPLSVTKQDNGKLLVKYKNTETGEEGEDTYDTVLWAVGRKGLVEDLNLSNA 298

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV   +   ++    E T   N++A+GD+I   PELTPVA+ AGRLL+RRLY     +MD
Sbjct: 299 GVTTFKDKIQV-DTKEATNVANIFAVGDIIYGKPELTPVAVLAGRLLARRLYGGSNQRMD 357

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYV 417
           Y  + T VFTP+EY C GLSEED+ +++G D VEV+H  + P E+ + ++   +   CY+
Sbjct: 358 YSDVATTVFTPLEYACVGLSEEDAVKQHGADGVEVFHGYYKPTEFFIPQK---SVRYCYL 414

Query: 418 KVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           K V ++T +  V G HYLGP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 415 KAVAERTGDQRVYGLHYLGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 464


>ref|XP_002071893.1| GK24920 [Drosophila willistoni]
 gb|EDW82879.1| GK24920 [Drosophila willistoni]
          Length = 550

 Score =  449 bits (1156), Expect = e-124
 Identities = 250/471 (53%), Positives = 318/471 (67%), Gaps = 17/471 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGS GLAC+KEA + G +V  LD+VKP+P GT WG+GGTCVNVGCIPKKL
Sbjct: 67  NYDYDLVVIGGGSAGLACAKEAVTNGARVACLDFVKPTPIGTKWGVGGTCVNVGCIPKKL 126

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + H+ A++GWNV          DW +LVS+V            V+LR K+
Sbjct: 127 MHQASLLGEAV-HEAAAYGWNVDDKIKP----DWSKLVSSVQNHIKSVNWVTRVDLRDKK 181

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+F
Sbjct: 182 VEYINGLGSFVDSHTL-LAKLKSGERTITAQSFVIAVGGRPRYPEIPGAVEYGITSDDLF 240

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +   EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME +
Sbjct: 241 SL-DHEPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME-E 298

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            GI F+RKTVP S+ K + G+LLVK+  TE G+  E+ FDTVL A GR   V  L L  A
Sbjct: 299 RGIPFLRKTVPLSVEKQEDGRLLVKYENTETGEVSEDVFDTVLWAIGRKGLVDDLNLPNA 358

Query: 299 GVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV +++   +I V++ E T   ++YA+GD+I   PELTPVA+ AGRLL+RRL+   T +M
Sbjct: 359 GVLVHK--DKIQVDSLETTNVGHIYAVGDIIYGKPELTPVAVLAGRLLARRLFANATQRM 416

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY  + T VFTP+EY C GLSEED+ + YG++ VEVYH  + P E+ + ++   +   CY
Sbjct: 417 DYADVATTVFTPLEYACVGLSEEDAIKTYGEEEVEVYHGYYKPTEFFIPQK---SVRYCY 473

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           VK V ++     V G HYLGP+AGEV Q    A+K G T   L++TVGIHP
Sbjct: 474 VKAVAERNGQQRVYGLHYLGPSAGEVIQGFAAALKSGLTVHTLMNTVGIHP 524


>gb|AAH07489.3| TXNRD2 protein [Homo sapiens]
          Length = 485

 Score =  449 bits (1156), Expect = e-124
 Identities = 244/473 (51%), Positives = 318/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 1   YDLLVVGGGSGGLACAKEAAQLGRKVSVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQ 60

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VKY
Sbjct: 61  AALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKY 115

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDIF
Sbjct: 116 FNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIF 173

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M   
Sbjct: 174 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-AS 231

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L+
Sbjct: 232 HGTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLE 289

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP+AI AGRLL +RL+   + 
Sbjct: 290 KAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSD 349

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A  
Sbjct: 350 LMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQ 406

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 407 CYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 459


>emb|CBY19735.1| unnamed protein product [Oikopleura dioica]
          Length = 596

 Score =  449 bits (1155), Expect = e-124
 Identities = 244/470 (51%), Positives = 313/470 (66%), Gaps = 14/470 (2%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGLA SKEAA  GKKV VLD+VKPSP GT WGLGGTCVNVGCIPKKL
Sbjct: 114 NYDYDLVVIGGGSGGLAASKEAAKLGKKVAVLDFVKPSPAGTQWGLGGTCVNVGCIPKKL 173

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQS+L+GE + HD   +GWN   V  +  +  W+++   V            VELR   
Sbjct: 174 MHQSALLGEAI-HDAKKYGWN---VEPEKISHSWEKMQMAVGDYIGSINWGYKVELRDNN 229

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGELAVSSDDIFW 180
           VKY N  G   D HT+   + +  T+E+TT+++++A G RPR     G E A+SSDD+FW
Sbjct: 230 VKYLNSYGEIKDRHTVVCTNKRGKTEELTTQNILVATGERPRLPDIPGIEHAISSDDLFW 289

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           + +  PGKTLVVGASYVALECAGFLKG+G  V + VRSI LRGFDQ  A  +G ++E ++
Sbjct: 290 LPEC-PGKTLVVGASYVALECAGFLKGLGLDVDICVRSIFLRGFDQQCADIVGNHLEKEA 348

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           G + IR   P SI KL++G L V     +G    + + TVL A GRDP  + +GL+   V
Sbjct: 349 GCKMIRPATPTSIEKLENGMLKVH--ISNGTTVVDEYKTVLMAIGRDPCTSGIGLENVKV 406

Query: 301 KLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDY 358
           +L E +G++ VN+ E+T   NV+AIGD++ D  ELTPVAIQAGRLL+RR+Y     +M Y
Sbjct: 407 ELAE-SGKVIVNDGEETNIENVFAIGDILKDRLELTPVAIQAGRLLARRMYAGAVEKMSY 465

Query: 359 DKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVK 418
           + + T VFTP+EY  CGLSEE + E+YG D++EVYH+ F PLEW++  +    A  CY+K
Sbjct: 466 NTVATTVFTPLEYSACGLSEEKAIEKYGLDNIEVYHRKFWPLEWTVPGKD---ANLCYMK 522

Query: 419 VVCDKTR-NNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +  +   N  V+G HY+GPNAGEV Q    AMK G T   L  TVGIHP
Sbjct: 523 AITIRHEPNEPVIGLHYVGPNAGEVMQGFSAAMKSGLTKTILDGTVGIHP 572


>ref|NP_001152971.1| thioredoxin reductase 2 precursor [Macaca mulatta]
          Length = 524

 Score =  449 bits (1155), Expect = e-124
 Identities = 246/474 (51%), Positives = 317/474 (66%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+VIGGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVIGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D   +GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 99  QAALLGGLI-QDAPHYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 153

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 154 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 211

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+M  
Sbjct: 212 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMIRSIPLRGFDQQMSSMVIEHM-A 269

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G +F+R   P  + +L  G L V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 270 SHGTQFLRGCAPSRVRRLPDGHLQVTW--EDCTTGKEDTGTFDTVLWAIGRVPDTRSLNL 327

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 328 EKAGVDTSPDTQKILVDSREGTSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 387

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 388 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 444

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 445 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 498


>ref|NP_001171496.1| thioredoxin reductase 1 isoform 1 [Apis mellifera]
          Length = 537

 Score =  448 bits (1153), Expect = e-124
 Identities = 238/467 (50%), Positives = 314/467 (67%), Gaps = 12/467 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA +FG KV VLD+V PSP G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 54  YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 113

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+GE + HD  S+GW +   + +    DW+ L + V            VELR+K+++Y
Sbjct: 114 AALLGESI-HDSVSYGWQL--PDPKTIKNDWEALRTAVQNHVKSVNWVTRVELRTKKIEY 170

Query: 124 ENVLGSFVDPHTLKLWHPKKG-TKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWM 181
            N LG F D HT+ L   K G  KE T ++++IAVGGRPR     G  E  ++SDDIF +
Sbjct: 171 FNALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSL 229

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
            +K PGKTL+VGA Y+ LECAGFL G+GY   VMVRSI+LRGFDQ MAS + + ME + G
Sbjct: 230 -EKAPGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRG 287

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVK 301
           + FI +  P  I K   G+LLV W+ +D    ++TFDTVL A GR P   +L  +  G+K
Sbjct: 288 VHFIYEAKPSKIEKQADGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLK 347

Query: 302 LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
           L  +T +I   +EQT  PNVYA+GDV+   PELTPVAI AGRLL+RRL+   T QMDY  
Sbjct: 348 LVPETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVN 407

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           + T VF+P+EYGC GLSEE +   +G+D +E+YH  + P E+ + ++      +CY+KV+
Sbjct: 408 VATTVFSPLEYGCVGLSEEAAIAIHGNDKIEIYHAYYKPTEFFIPQKD---VSNCYLKVI 464

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             +  +  VLG H++GPNAGEV Q    A+K   T+ +L DTVGIHP
Sbjct: 465 AFRNGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHP 511


>gb|AAP93583.1| thioredoxin reductase [Apis mellifera ligustica]
          Length = 485

 Score =  448 bits (1153), Expect = e-124
 Identities = 238/467 (50%), Positives = 314/467 (67%), Gaps = 12/467 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA +FG KV VLD+V PSP G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 2   YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 61

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+GE + HD  S+GW +   + +    DW+ L + V            VELR+K+++Y
Sbjct: 62  AALLGESI-HDSVSYGWQL--PDPKTIKNDWEALRTAVQNHVKSVNWVTRVELRTKKIEY 118

Query: 124 ENVLGSFVDPHTLKLWHPKKG-TKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWM 181
            N LG F D HT+ L   K G  KE T ++++IAVGGRPR     G  E  ++SDDIF +
Sbjct: 119 FNALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSL 177

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
            +K PGKTL+VGA Y+ LECAGFL G+GY   VMVRSI+LRGFDQ MAS + + ME + G
Sbjct: 178 -EKAPGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRG 235

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVK 301
           + FI +  P  I K   G+LLV W+ +D    ++TFDTVL A GR P   +L  +  G+K
Sbjct: 236 VHFIYEAKPSKIEKQADGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLK 295

Query: 302 LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
           L  +T +I   +EQT  PNVYA+GDV+   PELTPVAI AGRLL+RRL+   T QMDY  
Sbjct: 296 LVPETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVN 355

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           + T VF+P+EYGC GLSEE +   +G+D +E+YH  + P E+ + ++      +CY+KV+
Sbjct: 356 VATTVFSPLEYGCVGLSEEAAIAIHGNDKIEIYHAYYKPTEFFIPQKD---VSNCYLKVI 412

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             +  +  VLG H++GPNAGEV Q    A+K   T+ +L DTVGIHP
Sbjct: 413 AFRNGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHP 459


>ref|NP_001171497.1| thioredoxin reductase 1 isoform 2 [Apis mellifera]
          Length = 494

 Score =  448 bits (1153), Expect = e-124
 Identities = 238/467 (50%), Positives = 314/467 (67%), Gaps = 12/467 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLA +KEA +FG KV VLD+V PSP G++WGLGGTCVNVGCIPKKLMHQ
Sbjct: 11  YDLIVIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRGSTWGLGGTCVNVGCIPKKLMHQ 70

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+GE + HD  S+GW +   + +    DW+ L + V            VELR+K+++Y
Sbjct: 71  AALLGESI-HDSVSYGWQL--PDPKTIKNDWEALRTAVQNHVKSVNWVTRVELRTKKIEY 127

Query: 124 ENVLGSFVDPHTLKLWHPKKG-TKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWM 181
            N LG F D HT+ L   K G  KE T ++++IAVGGRPR     G  E  ++SDDIF +
Sbjct: 128 FNALGYFKDQHTI-LGKLKNGEEKEFTAQNILIAVGGRPRYPDIPGALEYGITSDDIFSL 186

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
            +K PGKTL+VGA Y+ LECAGFL G+GY   VMVRSI+LRGFDQ MAS + + ME + G
Sbjct: 187 -EKAPGKTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEME-RRG 244

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVK 301
           + FI +  P  I K   G+LLV W+ +D    ++TFDTVL A GR P   +L  +  G+K
Sbjct: 245 VHFIYEAKPSKIEKQADGRLLVHWVDKDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLK 304

Query: 302 LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
           L  +T +I   +EQT  PNVYA+GDV+   PELTPVAI AGRLL+RRL+   T QMDY  
Sbjct: 305 LVPETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYVN 364

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           + T VF+P+EYGC GLSEE +   +G+D +E+YH  + P E+ + ++      +CY+KV+
Sbjct: 365 VATTVFSPLEYGCVGLSEEAAIAIHGNDKIEIYHAYYKPTEFFIPQKD---VSNCYLKVI 421

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             +  +  VLG H++GPNAGEV Q    A+K   T+ +L DTVGIHP
Sbjct: 422 AFRNGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHP 468


>gb|EFN67124.1| Thioredoxin reductase 1, mitochondrial [Camponotus floridanus]
          Length = 537

 Score =  448 bits (1152), Expect = e-123
 Identities = 235/468 (50%), Positives = 313/468 (66%), Gaps = 10/468 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLA +KEA     KV VLDYV PSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 52  YTYDLLVIGGGSGGLAAAKEAVGLNAKVAVLDYVTPSPLGTTWGLGGTCVNVGCIPKKLM 111

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+GE + H+ A+FGW +   + +    +W+ L + V            VELR+K+V
Sbjct: 112 HQAALLGEAV-HEAATFGWQL--PDPKTVKINWEALKTAVQNHVKSVNWVTRVELRTKKV 168

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N LG F+D HT+     K   K  T ++++IAVGGRPR     G  E  +SSDDIF 
Sbjct: 169 DYFNALGHFMDAHTVVGVTKKGEEKVFTAKNILIAVGGRPRYPDIPGALEYGISSDDIFS 228

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           + ++ PGKTLVVGA Y+ LECAGFL G+GY   +MVRSI+LRGFDQ MA+ + E ME Q 
Sbjct: 229 L-ERAPGKTLVVGAGYIGLECAGFLNGLGYDTTIMVRSIVLRGFDQQMANLVAEEME-QR 286

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           G+ FI +  P+ + K + G+LLV W+ +DG   ++ +DTVL A GR     +L  + AG+
Sbjct: 287 GVHFIYQAKPKKVAKQEDGRLLVDWVDKDGQIHQDVYDTVLFAIGRRALTEELKPENAGL 346

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
           KL  +T +I   NEQT  PN+YA+GDV+   PELTPVAI AG+LL+RRL++  T QMDY 
Sbjct: 347 KLVPETNKIEAINEQTNVPNIYAVGDVLHKRPELTPVAIHAGKLLARRLFDNSTEQMDYT 406

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKV 419
            + T VF+P+EYGC GLSEE +   +G++ +E+YH  + P E+ + ++     + CYVKV
Sbjct: 407 NVATTVFSPLEYGCVGLSEEAAIGLHGEEEIEIYHAYYKPTEFFVPQKD---VDRCYVKV 463

Query: 420 VCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           V  ++ +  VLG H++GPNAGEV Q    A+K G T  +L  TVGIHP
Sbjct: 464 VAFRSGDQRVLGIHFVGPNAGEVIQGFAAAIKCGLTIPKLKATVGIHP 511


>ref|XP_002830900.1| PREDICTED: thioredoxin reductase 2, mitochondrial-like [Pongo
           abelii]
          Length = 522

 Score =  447 bits (1151), Expect = e-123
 Identities = 244/474 (51%), Positives = 317/474 (66%), Gaps = 23/474 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 98

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D   +GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 99  QAALLGGLI-QDAPHYGWEV----AQPVLHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 153

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 154 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 211

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 212 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSLVIEHM-A 269

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 270 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDRATGKEDMGTFDTVLWAIGRVPDTRSLNL 327

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 328 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 387

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 388 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 444

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     +LG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 445 QCYVKMVCLREPPQLLLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 498


>ref|XP_001966148.1| GF19373 [Drosophila ananassae]
 gb|EDV38557.1| GF19373 [Drosophila ananassae]
          Length = 537

 Score =  447 bits (1149), Expect = e-123
 Identities = 253/472 (53%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LDYVKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 53  SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDYVKPTPTLGTKWGVGGTCVNVGCIPKK 112

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + AS+GWNV          DW +LV +V            V+LR K
Sbjct: 113 LMHQASLLGEAVH-EAASYGWNVDDKIKP----DWGKLVQSVQNHIKSVNWVTRVDLRDK 167

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDDI
Sbjct: 168 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDI 226

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +   EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 227 FSLDH-EPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVASSME- 284

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K + G+LLVK+   E G+  E+TFDTVL A GR   V  L L  
Sbjct: 285 ERGIPFLRKTVPLSVEKQEDGKLLVKFKNVETGEEAEDTFDTVLWAIGRKGLVDDLNLPN 344

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV  N +  +I V++++ T   N+YA+GD+I   PELTPVAI AGRLL+RRLY   T +
Sbjct: 345 AGV--NTQKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAILAGRLLARRLYGGATQR 402

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ ++YG D VEV+H  + P E+ + ++   +   C
Sbjct: 403 MDYADVATTVFTPLEYACVGLSEEDAVKQYGADEVEVFHGYYKPTEFFIPQK---SVRYC 459

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 460 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 511


>ref|XP_975772.1| PREDICTED: similar to thioredoxin reductase isoform 2 [Tribolium
           castaneum]
          Length = 492

 Score =  446 bits (1148), Expect = e-123
 Identities = 237/467 (50%), Positives = 309/467 (66%), Gaps = 11/467 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           +YDLVVIGGGSGGLA +KEAA  G KV VLDYV PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   EYDLVVIGGGSGGLAAAKEAAGLGAKVAVLDYVTPSPKGTKWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+GE +  D  S+GW            DW  L   V            VELR K+V+
Sbjct: 69  QAALLGEAI-EDAKSYGWQFPQPEN--IKHDWASLRQAVQNHIKSVNWVTRVELRDKKVE 125

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWM 181
           Y N LG F DPHT+     K+G + +T+++ +IAVGGRPR     G  E  ++SDDIF +
Sbjct: 126 YINGLGVFKDPHTVHT-VTKQGERTLTSKYFLIAVGGRPRYPNIPGAVEYGITSDDIFSL 184

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
            ++ PGKTLVVGA Y+ LECAGFL+G+GY   VMVRS++LRGFDQ MA  I   ME + G
Sbjct: 185 -EEAPGKTLVVGAGYIGLECAGFLRGLGYDATVMVRSVVLRGFDQQMAKLIASAME-EKG 242

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVK 301
           ++F+ K +P+S+ K    +LLVKW  E G  FE+ FDTVL A GR     +L LD+AGVK
Sbjct: 243 VKFLHKCLPKSVEKRSDNKLLVKWSNETGQEFEDVFDTVLFAIGRRALTRELHLDKAGVK 302

Query: 302 LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
           +     +I   NEQ+  P+++A+GDV+   PELTPVAI AGRLL+RRL+   TVQMDYD 
Sbjct: 303 VAGDGEKIDAMNEQSNVPHIFAVGDVLYKKPELTPVAIHAGRLLARRLFGNSTVQMDYDN 362

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           + T VF+P+EYG  G+SEE + + +G++++E+YH  + P E+ + ++   +   CY+KVV
Sbjct: 363 VATTVFSPLEYGSVGISEETAIQRFGENNIEIYHAYYKPTEFFIPQR---SIAHCYLKVV 419

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             +     VLG H++GP AGEV Q    AMK   T + L+ TVGIHP
Sbjct: 420 AKREGPQQVLGMHFIGPQAGEVIQGFAAAMKCNLTVNALMSTVGIHP 466


>pdb|3DGZ|A Chain A, Crystal Structure Of Mouse Mitochondrial Thioredoxin
           Reductase, C-Terminal 3-Residue Truncation
          Length = 488

 Score =  446 bits (1146), Expect = e-123
 Identities = 243/473 (51%), Positives = 317/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 7   FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 66

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 67  AALLGGMI-RDAHHYGWEV----AQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 121

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 122 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 179

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 180 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHME-S 237

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 238 HGTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 295

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 296 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 355

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EYGC GLSEE++   +G + VEVYH  + PLE+++A++    A  
Sbjct: 356 LMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQ 412

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 413 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 465


>gb|EDK97524.1| thioredoxin reductase 2, isoform CRA_a [Mus musculus]
          Length = 525

 Score =  446 bits (1146), Expect = e-123
 Identities = 243/473 (51%), Positives = 317/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 43  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 102

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 103 AALLGGMI-RDAHHYGWEV----AQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 157

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 158 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 215

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 216 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHME-S 273

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 274 HGTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 331

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 332 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 391

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EYGC GLSEE++   +G + VEVYH  + PLE+++A++    A  
Sbjct: 392 LMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQ 448

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 449 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 501


>sp|Q9JLT4|TRXR2_MOUSE RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Thioredoxin reductase TR3; Flags: Precursor
 gb|AAD51323.1|AF171053_1 thioredoxin reductase TR3 [Mus musculus]
          Length = 524

 Score =  446 bits (1146), Expect = e-123
 Identities = 243/473 (51%), Positives = 317/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 40  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 99

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 100 AALLGGMI-RDAHHYGWEV----AQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 154

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 155 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 212

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 213 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHME-S 270

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 271 HGTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 328

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 329 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 388

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EYGC GLSEE++   +G + VEVYH  + PLE+++A++    A  
Sbjct: 389 LMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQ 445

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 446 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 498


>gb|AAF03359.1|AF136399_1 thioredoxin reductase [Mus musculus]
          Length = 528

 Score =  446 bits (1146), Expect = e-123
 Identities = 243/473 (51%), Positives = 317/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 44  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 103

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 104 AALLGGMI-RDAHHYGWEV----AQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 158

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 159 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 216

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 217 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHME-S 274

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 275 HGTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 332

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 333 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 392

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EYGC GLSEE++   +G + VEVYH  + PLE+++A++    A  
Sbjct: 393 LMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQ 449

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 450 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 502


>ref|NP_038739.2| thioredoxin reductase 2, mitochondrial precursor [Mus musculus]
 gb|AAL90457.1| thioredoxin reductase [Mus musculus]
 gb|AAH52157.3| Thioredoxin reductase 2 [Mus musculus]
          Length = 527

 Score =  446 bits (1146), Expect = e-123
 Identities = 243/473 (51%), Positives = 317/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 43  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 102

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 103 AALLGGMI-RDAHHYGWEV----AQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 157

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 158 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 215

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 216 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHME-S 273

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 274 HGTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 331

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 332 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 391

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EYGC GLSEE++   +G + VEVYH  + PLE+++A++    A  
Sbjct: 392 LMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQ 448

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 449 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 501


>pdb|1ZDL|A Chain A, Crystal Structure Of Mouse Thioredoxin Reductase Type 2
 pdb|1ZKQ|A Chain A, Crystal Structure Of Mouse Thioredoxin Reductase Type 2
          Length = 517

 Score =  446 bits (1146), Expect = e-123
 Identities = 243/473 (51%), Positives = 317/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 33  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 92

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 93  AALLGGMI-RDAHHYGWEV----AQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 147

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 148 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 205

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 206 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHME-S 263

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 264 HGTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 321

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 322 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 381

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EYGC GLSEE++   +G + VEVYH  + PLE+++A++    A  
Sbjct: 382 LMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQ 438

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 439 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 491


>dbj|BAA86986.2| thioredoxin reductase 2 [Mus musculus]
          Length = 520

 Score =  446 bits (1146), Expect = e-123
 Identities = 243/473 (51%), Positives = 317/473 (67%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 36  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 95

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 96  AALLGGMI-RDAHHYGWEV----AQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 150

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 151 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 208

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 209 WLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHME-S 266

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 267 HGTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 324

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 325 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 384

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EYGC GLSEE++   +G + VEVYH  + PLE+++A++    A  
Sbjct: 385 LMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRD---ASQ 441

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 442 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 494


>ref|XP_002920642.1| PREDICTED: thioredoxin reductase 2, mitochondrial-like [Ailuropoda
           melanoleuca]
          Length = 493

 Score =  445 bits (1144), Expect = e-123
 Identities = 243/474 (51%), Positives = 317/474 (66%), Gaps = 24/474 (5%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+VIGGGSGGLAC+KEAA  GKKV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 11  DYDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVEPSPRGTRWGLGGTCVNVGCIPKKLMH 70

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D   +GW V     Q    DW+ +   V            V+L+ ++VK
Sbjct: 71  QAALLGGMI-RDAPHYGWAV-----QPVLHDWRTMAEAVQNYVKSLNWGHRVQLQDRKVK 124

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFV+ HT  +    K  KE  ++  H+VIA GGRP+    + G  E  ++SDDI
Sbjct: 125 YFNIKASFVNEHT--VCGVAKDGKETLLSAEHIVIATGGRPKYPTHIEGALEYGITSDDI 182

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + EYM  
Sbjct: 183 FWLKE-SPGKTLVVGASYVALECAGFLTGLGLDTTVMIRSIPLRGFDQQMSSLVTEYMAS 241

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
           Q G  F+R   P  +  L  GQL V W  ED    +E   TF+TVL A GR P+   L L
Sbjct: 242 Q-GTRFLRGCTPSRVRGLPDGQLQVTW--EDLTSGKEDMGTFNTVLWAIGRIPETRSLNL 298

Query: 296 DEAGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  N  + +I V+ ++TT+ P++YAIGD+ +  PELTP AI AG+LL++RL  + +
Sbjct: 299 EKAGVNTNPNSQKILVDAQETTSVPHIYAIGDIAEGRPELTPTAIMAGKLLAQRLCGQSS 358

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G++ VEVYH  + PLE+++AE+    A 
Sbjct: 359 DVMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGEEHVEVYHAYYKPLEFTVAERD---AS 415

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 416 QCYIKMVCLRKPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 469


>ref|XP_002101164.1| GE15773 [Drosophila yakuba]
 gb|EDX02272.1| GE15773 [Drosophila yakuba]
          Length = 491

 Score =  445 bits (1144), Expect = e-123
 Identities = 248/472 (52%), Positives = 318/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LDYVKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDYVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDDKIKP----DWNKLVQSVQNHIKSVNWVTRVDLRDK 121

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 122 KVEYINGLGSFVDSHTL-LAKIKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F + ++EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 181 FSL-EREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 238

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RK+VP S+ K D G+LLVK+   E G+  E+ FDTVL A GR   V  L L  
Sbjct: 239 ERGIPFLRKSVPLSVEKQDDGKLLVKYKNVETGEEAEDVFDTVLWAIGRKGLVDDLNLPN 298

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 299 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGATQR 356

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +EYG D +EV+H  + P E+ + ++   +   C
Sbjct: 357 MDYKDVATTVFTPLEYACVGLSEEDAVKEYGADEIEVFHGYYKPTEFFIPQK---SVRYC 413

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 414 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 465


>ref|NP_001162173.1| thioredoxin reductase 2, mitochondrial [Sus scrofa]
 gb|ACZ63265.1| thioredoxin reductase 2 [Sus scrofa]
          Length = 513

 Score =  444 bits (1143), Expect = e-122
 Identities = 241/471 (51%), Positives = 313/471 (66%), Gaps = 19/471 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA  GKKV V+DYV PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 31  YDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVSPSPRGTRWGLGGTCVNVGCIPKKLMHQ 90

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q     W+++   V            V+L+ ++VKY
Sbjct: 91  AALLGGVI-RDAPHYGWEV----VQPALHSWRKMAEAVQNHVKSLNWGHRVQLQDRKVKY 145

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N   SFV+ HT  +    KG KEI  +  H+VIA GGRPR  A + G  E  ++SDDIF
Sbjct: 146 FNFKASFVNKHT--VCGVSKGGKEILLSAEHIVIATGGRPRYPAHIEGAVEYGITSDDIF 203

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LR FDQ MAS + E+M + 
Sbjct: 204 WLKE-SPGKTLVVGASYVALECAGFLTGLGLDATIMIRSIPLRAFDQQMASLVIEHMAVH 262

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFE-ETFDTVLNATGRDPDVAKLGLDEA 298
            G   ++  +P  + KL  GQL V W+    D  +  TFDTVL ATGR P++  L L++A
Sbjct: 263 -GTRILKGCMPLRVEKLPDGQLQVTWVDLASDRKDVGTFDTVLWATGRVPEIGSLNLEKA 321

Query: 299 GVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV  N  T +I V+  + T+ P++YAIGDV +  PELTP A+ AGRLL++RL    +  M
Sbjct: 322 GVHTNPHTQKILVDAQDATSVPHIYAIGDVAEGRPELTPTAVMAGRLLAQRLCGRSSDLM 381

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DYD + T VFTP+EYGC GLSEE +   +G++ VEVYH  + PLE+++ E+    A  CY
Sbjct: 382 DYDNVPTTVFTPLEYGCVGLSEEAAVARHGEEGVEVYHAYYKPLEFTVPERD---ASQCY 438

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +K+VC +     V G H+LGPNAGEVTQ   LA+K G +Y+Q++ TVGIHP
Sbjct: 439 IKMVCLREPPQLVRGLHFLGPNAGEVTQGFALALKCGASYEQVMRTVGIHP 489


>ref|XP_001455671.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK88274.1| unnamed protein product [Paramecium tetraurelia]
          Length = 486

 Score =  444 bits (1143), Expect = e-122
 Identities = 240/469 (51%), Positives = 316/469 (67%), Gaps = 17/469 (3%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL VIGGGSGGLAC+K+AA  G KV + D+VKPSP GT WGLGGTCVNVGCIPKKLMH 
Sbjct: 7   YDLFVIGGGSGGLACAKQAAKLGAKVALADFVKPSPLGTKWGLGGTCVNVGCIPKKLMHF 66

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPT-FDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           ++ +GE L HD    GW    V+ QV +  +W+++V NV             +L    VK
Sbjct: 67  AATLGE-LRHDQVEAGW----VDTQVDSKHNWEKMVENVNNHIRKLNFGYKNQLMRGDVK 121

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIFW 180
           Y N L   +D +T+KL   K   + +T ++++IAVGGRP     +    +L ++SDD+FW
Sbjct: 122 YYNKLAELIDANTIKLTDNKGQIETVTAKNILIAVGGRPSYPENIPNIQKLVITSDDLFW 181

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           + Q+ PGKTLVVGASYVALEC GFL G+G  V +MVRSILLRGFDQ++A KIG YME + 
Sbjct: 182 L-QENPGKTLVVGASYVALECGGFLHGIGNEVAIMVRSILLRGFDQEIAEKIGLYME-EK 239

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           GI FIR  VP  I   +  +  V WI  +G  +EE FDTVL ATGR  D  KL L++ GV
Sbjct: 240 GIRFIRGCVPDMIEATEDNKRKVTWII-NGQKYEEIFDTVLVATGRISDTQKLNLEKVGV 298

Query: 301 KLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDY 358
            +N K G+I  + +++T+ PN++AIGD ++  PELTP AI+ G+LL+ RL+N+ T  M Y
Sbjct: 299 NMN-KNGKILCSADDKTSVPNIFAIGDCVEGRPELTPTAIKCGQLLANRLFNKATELMSY 357

Query: 359 DKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVK 418
           + + T VFTP+EYGC G SEED+ +++G+D + VYH  F PLEW+  E    + ESC+ K
Sbjct: 358 EFVATTVFTPLEYGCIGYSEEDAIKKFGEDKITVYHSIFKPLEWNYFEMH--SGESCFAK 415

Query: 419 VVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           ++     N  V+GFHYLGP+AGEVTQ   +AMK+G T +Q   TVGIHP
Sbjct: 416 LIV-LNDNRRVIGFHYLGPHAGEVTQGYAVAMKMGVTKEQFDSTVGIHP 463


>gb|AAW25951.1| SJCHGC06622 protein [Schistosoma japonicum]
          Length = 615

 Score =  444 bits (1143), Expect = e-122
 Identities = 238/476 (50%), Positives = 305/476 (64%), Gaps = 19/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA  KEAA +G K  VLDYV+P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 125 YDYDLIIIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLM 184

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+   L  D   FGW   S++    + DW  +V  V            V LR   V
Sbjct: 185 HQAGLLSHSL-EDAQHFGW---SLDKSKISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAV 240

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G  ++PH +++    K    IT   +++A G RP+     G  E  ++SDD+F 
Sbjct: 241 TYLNARGMLLNPHEVQITEKNKKVSTITGNKIILATGERPKYPEIPGAIEYGITSDDLFS 300

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALECAGFL  +G  V VMVRSILLRGFDQ MA K+G+YME   
Sbjct: 301 LPY-FPGKTLVVGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NH 358

Query: 241 GIEFIRKTVPQSITKL--------DSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAK 292
           G++F +  VP  IT+L          G LLVK    DG  FEE F+TV+ A GR+P ++K
Sbjct: 359 GVKFAKLCVPDEITQLKPVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSK 418

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNE 351
           L  +  GVKL++    +  ++EQTT  N+YAIGD+    P+LTPVAI AGR L+RRL+  
Sbjct: 419 LNCEAVGVKLDKNGRVVCSDDEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAG 478

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            T   DY  + T VFTP+EYG CGLSEED+ E+YGD+ +EVYH +F PLEW++A +    
Sbjct: 479 ATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVAHR---E 535

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              CY+K+VC  + N  VLG H LGPNAGE+TQ   +A+K+G T +    T+GIHP
Sbjct: 536 DNVCYMKLVCRISDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHP 591


>ref|XP_002734086.1| PREDICTED: thioredoxin reductase 1-like [Saccoglossus kowalevskii]
          Length = 600

 Score =  444 bits (1142), Expect = e-122
 Identities = 237/473 (50%), Positives = 310/473 (65%), Gaps = 16/473 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL+VIGGGSGGLA SK+AA  G+KV V D+VKP+P GT+WGLGGTCVNVGCIPKKL
Sbjct: 114 SYDYDLIVIGGGSGGLAASKKAAEHGQKVAVFDFVKPTPKGTTWGLGGTCVNVGCIPKKL 173

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G  L  D   +GW          + +W  +   +            V+LR K 
Sbjct: 174 MHQAALLGHSLE-DAKKYGWEFDDK----ASHNWTTMRDAIQNHIGSLNWGYRVDLRDKN 228

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N    F DPHT+K  + K     +T +  +IAVGGRPR     G  E  ++SDD+F
Sbjct: 229 VTYHNAYAEFTDPHTVKAVNKKGKETVMTAKRFIIAVGGRPRYPDIPGAKEYCITSDDLF 288

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLV+GASYVALECAGFL G+GY   VMVRSILLRGFDQDMA++IG+YME  
Sbjct: 289 SLPYN-PGKTLVIGASYVALECAGFLAGIGYDTTVMVRSILLRGFDQDMANRIGDYMETH 347

Query: 240 SGIEFIRKTVPQSITKLDS---GQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++FI++ +P  + +L+    G+L V +  T  G+      +TV+ A GRD     +GL
Sbjct: 348 -GVKFIKEHIPTMVEQLEEGSPGKLRVSYKATNGGEIKTIECNTVIIAVGRDACTQTIGL 406

Query: 296 DEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           D+AGV+ N K G+I    E+T   ++YA+GDV++  PELTPVAIQAG LL+ RLY     
Sbjct: 407 DKAGVEYNVKNGKIPAQFEETNVSHIYALGDVLEGKPELTPVAIQAGTLLANRLYGGHVA 466

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY  + T VFTP+EYGCCGLSEED+  +YGD  VEV+H  F PLE ++A++       
Sbjct: 467 RCDYVNVPTTVFTPLEYGCCGLSEEDAINKYGDQLVEVFHTYFKPLEHTVAQR---EDNV 523

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C +  +N V+GFH LGPNAGE+TQ  G+AMK G +   L  ++GIHP
Sbjct: 524 CYGKIICHRVDSNRVVGFHVLGPNAGEITQGYGVAMKCGLSKGLLDLSIGIHP 576


>ref|NP_001080052.1| thioredoxin reductase 2 [Xenopus laevis]
          Length = 504

 Score =  444 bits (1142), Expect = e-122
 Identities = 234/473 (49%), Positives = 316/473 (66%), Gaps = 19/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL+VIGGGSGGLAC+K+AA FGKKV V DYV+PSP GT WG+GGTCVNVGCIPKKLM
Sbjct: 18  HDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLM 77

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++LIG  +  D   +GW            DW ++   V            ++L+ K+V
Sbjct: 78  HQAALIGSTM-KDAPHYGWG----TPYEIQHDWGKMAGAVQNYVKSLNWGHRIQLQDKKV 132

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDD 177
           KY N+  +FVD H ++     K  KE  +T +++VIA GGRP+    + G  E  ++SDD
Sbjct: 133 KYFNLKANFVDEHCIR--GVTKAGKETLVTAQNIVIATGGRPKYPTHVPGALEYGITSDD 190

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           +FW+K+  PGKTLVVGASYV+LECAGFL G+G     MVRSI LRGFDQ MA  + +YME
Sbjct: 191 LFWLKE-SPGKTLVVGASYVSLECAGFLTGIGLNTTAMVRSIPLRGFDQQMAYLVADYME 249

Query: 238 MQSGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
              G +F+ K  P  + KL +G+L V W  T+ G    + +DTV+ A GR  +   L L+
Sbjct: 250 -SHGTKFLWKCTPSHVEKLKNGKLQVTWKNTQSGKEGVDIYDTVMWAVGRAAETQYLNLE 308

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           + GVK+  +TG+I V+ +E T+ P++YAIGD+ +  PELTP AI AG+LL+ RL++    
Sbjct: 309 KVGVKIKPETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLAIRLFSGSAE 368

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDYD + T VFTP+EYGC G+SEE++KE YGDD++EV+H  + PLE+++AE+    A  
Sbjct: 369 LMDYDSVPTTVFTPLEYGCVGISEEEAKERYGDDNIEVFHAFYKPLEFTVAERD---ASQ 425

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K++C +  +  +LG H  GPNAGEV Q   L +K G TY QL+ TVGIHP
Sbjct: 426 CYIKIICLRKHDQRILGLHLTGPNAGEVIQGFALGIKCGATYPQLMCTVGIHP 478


>gb|AAH56136.1| Txnrd2 protein [Xenopus laevis]
          Length = 502

 Score =  444 bits (1142), Expect = e-122
 Identities = 234/473 (49%), Positives = 316/473 (66%), Gaps = 19/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDL+VIGGGSGGLAC+K+AA FGKKV V DYV+PSP GT WG+GGTCVNVGCIPKKLM
Sbjct: 18  HDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLM 77

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++LIG  +  D   +GW            DW ++   V            ++L+ K+V
Sbjct: 78  HQAALIGSTM-KDAPHYGWG----TPYEIQHDWGKMAGAVQNYVKSLNWGHRIQLQDKKV 132

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDD 177
           KY N+  +FVD H ++     K  KE  +T +++VIA GGRP+    + G  E  ++SDD
Sbjct: 133 KYFNLKANFVDEHCIR--GVTKAGKETLVTAQNIVIATGGRPKYPTHVPGALEYGITSDD 190

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           +FW+K+  PGKTLVVGASYV+LECAGFL G+G     MVRSI LRGFDQ MA  + +YME
Sbjct: 191 LFWLKE-SPGKTLVVGASYVSLECAGFLTGIGLNTTAMVRSIPLRGFDQQMAYLVADYME 249

Query: 238 MQSGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
              G +F+ K  P  + KL +G+L V W  T+ G    + +DTV+ A GR  +   L L+
Sbjct: 250 -SHGTKFLWKCTPSHVEKLKNGKLQVTWKNTQSGKEGVDIYDTVMWAVGRAAETQYLNLE 308

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           + GVK+  +TG+I V+ +E T+ P++YAIGD+ +  PELTP AI AG+LL+ RL++    
Sbjct: 309 KVGVKIKPETGKIIVDASEATSVPHIYAIGDITEGRPELTPTAIAAGKLLAIRLFSGSAE 368

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDYD + T VFTP+EYGC G+SEE++KE YGDD++EV+H  + PLE+++AE+    A  
Sbjct: 369 LMDYDSVPTTVFTPLEYGCVGISEEEAKERYGDDNIEVFHAFYKPLEFTVAERD---ASQ 425

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K++C +  +  +LG H  GPNAGEV Q   L +K G TY QL+ TVGIHP
Sbjct: 426 CYIKIICLRKHDQRILGLHLTGPNAGEVIQGFALGIKCGATYPQLMCTVGIHP 478


>gb|EFZ12491.1| hypothetical protein SINV_11881 [Solenopsis invicta]
          Length = 545

 Score =  444 bits (1141), Expect = e-122
 Identities = 234/468 (50%), Positives = 313/468 (66%), Gaps = 11/468 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLA +KEA   G KV VLDYV PSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 61  YMYDLLVIGGGSGGLAAAKEAVGLGAKVAVLDYVTPSPLGTTWGLGGTCVNVGCIPKKLM 120

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+GE L HD A+FGW    ++ +    DW+ + + V            VELR+K+V
Sbjct: 121 HQAALLGESL-HDAAAFGW---QLDPKSIKNDWETMKNVVQNHVKSVNWVTRVELRTKKV 176

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           +Y N LG F D HT+     K   K +T ++++IAVGGRPR     G  E  +SSDDIF 
Sbjct: 177 EYFNALGYFKDAHTVAGVSKKGDEKILTAKNIIIAVGGRPRYPDIPGALEYGISSDDIFS 236

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           + ++ PGKTLVVGA Y+ LECAGFL G+GY   ++VR+I+LRGFD+ MA  I E M+ Q 
Sbjct: 237 L-ERAPGKTLVVGAGYIGLECAGFLNGLGYDTTLIVRTIVLRGFDRQMAQHITEEMQ-QR 294

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           G+ FI +   + ++K + G+LL  W+ +DG+  ++ +DTVL A GR     +L  + AG+
Sbjct: 295 GVNFIYEAKLKKVSKREDGRLLTDWVDKDGNVHQDVYDTVLFAIGRRSLTQELKPENAGL 354

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
           KL  +TG+I   NEQT  PN+YA+GDV+   PELTPVAI AG+LL++RL+   T +MDY 
Sbjct: 355 KLVPETGKIDAVNEQTNVPNIYAVGDVLHKKPELTPVAIHAGKLLAKRLFGNSTDKMDYT 414

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKV 419
            + T VFTP+EYGC GLSEE + E +G+D +E++H  + P E+ + ++     + CYVKV
Sbjct: 415 NVATTVFTPLEYGCVGLSEEAAVELHGEDQIEIFHAYYKPTEFFVPQKN---VDRCYVKV 471

Query: 420 VCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           V  +  +  VLG H++GPNAGEV Q    A+K G T   L  TVGIHP
Sbjct: 472 VALRHHDEKVLGMHFIGPNAGEVIQGFAAAIKCGLTIPLLKSTVGIHP 519


>pdb|2X8C|A Chain A, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           With The Reduced C-Terminal End
 pdb|2X8C|B Chain B, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           With The Reduced C-Terminal End
 pdb|2X8G|A Chain A, Oxidized Thioredoxin Glutathione Reductase From
           Schistosoma Mansoni
 pdb|2X8H|A Chain A, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           In Complex With Gsh
 pdb|2X99|A Chain A, Thioredoxin Glutathione Reductase From Schistosoma Mansoni
           In Complex With Nadph
          Length = 598

 Score =  444 bits (1141), Expect = e-122
 Identities = 239/476 (50%), Positives = 304/476 (63%), Gaps = 19/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAA +G K  VLDYV+P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+   L  D   FGW   S++    + +W  +V  V            V LR  QV
Sbjct: 166 HQAGLLSHAL-EDAEHFGW---SLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQV 221

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G  + PH +++    +    IT   +++A G RP+     G  E  ++SDD+F 
Sbjct: 222 TYLNAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFS 281

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLV+GASYVALECAGFL  +G  V VMVRSILLRGFDQ MA K+G+YME   
Sbjct: 282 LPY-FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NH 339

Query: 241 GIEFIRKTVPQSITKL--------DSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAK 292
           G++F +  VP  I +L          G LLVK    DG  FEE F+TV+ A GR+P ++K
Sbjct: 340 GVKFAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSK 399

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNE 351
           +  +  GVKL++    +  ++EQTT  NVYAIGD+    P+LTPVAIQAGR L+RRL+  
Sbjct: 400 VLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAG 459

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            T   DY  + T VFTP+EYG CGLSEED+ E+YGD  +EVYH NF PLEW++A +    
Sbjct: 460 ATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHR---E 516

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              CY+K+VC K+ N  VLG H LGPNAGE+TQ   +A+K+G T      T+GIHP
Sbjct: 517 DNVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHP 572


>pdb|3H4K|A Chain A, Crystal Structure Of The Wild Type Thioredoxin Glutatione
           Reductase From Schistosoma Mansoni In Complex With
           Auranofin
          Length = 598

 Score =  444 bits (1141), Expect = e-122
 Identities = 239/476 (50%), Positives = 304/476 (63%), Gaps = 19/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAA +G K  VLDYV+P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+   L  D   FGW   S++    + +W  +V  V            V LR  QV
Sbjct: 166 HQAGLLSHAL-EDAEHFGW---SLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQV 221

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G  + PH +++    +    IT   +++A G RP+     G  E  ++SDD+F 
Sbjct: 222 TYLNAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFS 281

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLV+GASYVALECAGFL  +G  V VMVRSILLRGFDQ MA K+G+YME   
Sbjct: 282 LPY-FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NH 339

Query: 241 GIEFIRKTVPQSITKL--------DSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAK 292
           G++F +  VP  I +L          G LLVK    DG  FEE F+TV+ A GR+P ++K
Sbjct: 340 GVKFAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSK 399

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNE 351
           +  +  GVKL++    +  ++EQTT  NVYAIGD+    P+LTPVAIQAGR L+RRL+  
Sbjct: 400 VLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAG 459

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            T   DY  + T VFTP+EYG CGLSEED+ E+YGD  +EVYH NF PLEW++A +    
Sbjct: 460 ATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHR---E 516

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              CY+K+VC K+ N  VLG H LGPNAGE+TQ   +A+K+G T      T+GIHP
Sbjct: 517 DNVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHP 572


>pdb|2V6O|A Chain A, Structure Of Schistosoma Mansoni Thioredoxin-Glutathione
           Reductase (Smtgr)
          Length = 596

 Score =  444 bits (1141), Expect = e-122
 Identities = 239/476 (50%), Positives = 304/476 (63%), Gaps = 19/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAA +G K  VLDYV+P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+   L  D   FGW   S++    + +W  +V  V            V LR  QV
Sbjct: 166 HQAGLLSHAL-EDAEHFGW---SLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQV 221

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G  + PH +++    +    IT   +++A G RP+     G  E  ++SDD+F 
Sbjct: 222 TYLNAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFS 281

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLV+GASYVALECAGFL  +G  V VMVRSILLRGFDQ MA K+G+YME   
Sbjct: 282 LPY-FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NH 339

Query: 241 GIEFIRKTVPQSITKL--------DSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAK 292
           G++F +  VP  I +L          G LLVK    DG  FEE F+TV+ A GR+P ++K
Sbjct: 340 GVKFAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSK 399

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNE 351
           +  +  GVKL++    +  ++EQTT  NVYAIGD+    P+LTPVAIQAGR L+RRL+  
Sbjct: 400 VLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAG 459

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            T   DY  + T VFTP+EYG CGLSEED+ E+YGD  +EVYH NF PLEW++A +    
Sbjct: 460 ATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHR---E 516

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              CY+K+VC K+ N  VLG H LGPNAGE+TQ   +A+K+G T      T+GIHP
Sbjct: 517 DNVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHP 572


>ref|XP_001425944.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK58546.1| unnamed protein product [Paramecium tetraurelia]
          Length = 486

 Score =  444 bits (1141), Expect = e-122
 Identities = 239/469 (50%), Positives = 312/469 (66%), Gaps = 15/469 (3%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL VIGGGSGGLAC+K+AA  G KV + D+VKPSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 6   EFDLFVIGGGSGGLACAKQAAKLGAKVALADFVKPSPLGTKWGLGGTCVNVGCIPKKLMH 65

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
            +S +GE L HD    GW    V+ +    +W+++V NV             +L    VK
Sbjct: 66  FASTLGE-LRHDQVEAGWIDTQVDSK---HNWEKMVENVNNHIRKLNFGYKNQLMRGDVK 121

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIFW 180
           Y N L   +D +T+KL   K   + +  + +VIAVGGRP     +    +L ++SDD+FW
Sbjct: 122 YYNKLAELIDANTIKLTDNKGKIETVRAKTIVIAVGGRPSYPENIPNIQKLVITSDDLFW 181

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           + Q+ PGKTLVVGASYVALEC GFL G+G  V +MVRSILLRGFDQ++A KIG YME + 
Sbjct: 182 L-QENPGKTLVVGASYVALECGGFLHGIGNEVAIMVRSILLRGFDQEIAEKIGLYME-EK 239

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           GI FIR  VP  I   +  +  V WI  +G  +EE FDTVL ATGR  D  KL L++ GV
Sbjct: 240 GIRFIRGCVPDMIEATEDNKRKVTWIL-NGQKYEEIFDTVLVATGRISDTQKLNLEKVGV 298

Query: 301 KLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDY 358
            LN K G+I  + +++T+ PN++AIGD ++  PELTP AI+ G+LL+ RL+N+    M Y
Sbjct: 299 NLN-KNGKILCSADDKTSVPNIFAIGDCVEGRPELTPTAIKCGQLLANRLFNKANELMSY 357

Query: 359 DKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVK 418
           D + T VFTP+EYGC G SEED+ +++G+D + VYH  F PLEW+  E    + ESC+ K
Sbjct: 358 DYVATTVFTPLEYGCIGYSEEDAIKKFGEDKITVYHSIFKPLEWNYFEMH--SGESCFAK 415

Query: 419 VVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           ++     N  V+GFHYLGP+AGEVTQ   +AMK+G T +Q   TVGIHP
Sbjct: 416 LIV-LNNNRRVIGFHYLGPHAGEVTQGYAVAMKMGVTKEQFDSTVGIHP 463


>gb|AAK85233.1|AF395822_1 thioredoxin glutathione reductase [Schistosoma mansoni]
          Length = 598

 Score =  444 bits (1141), Expect = e-122
 Identities = 239/476 (50%), Positives = 304/476 (63%), Gaps = 19/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLA  KEAA +G K  VLDYV+P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+   L  D   FGW   S++    + +W  +V  V            V LR  QV
Sbjct: 166 HQAGLLSHAL-EDAEHFGW---SLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQV 221

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G  + PH +++    +    IT   +++A G RP+     G  E  ++SDD+F 
Sbjct: 222 TYLNAKGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYPEIPGAVEYGITSDDLFS 281

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLV+GASYVALECAGFL  +G  V VMVRSILLRGFDQ MA K+G+YME   
Sbjct: 282 LPY-FPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NH 339

Query: 241 GIEFIRKTVPQSITKL--------DSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAK 292
           G++F +  VP  I +L          G LLVK    DG  FEE F+TV+ A GR+P ++K
Sbjct: 340 GVKFAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSK 399

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNE 351
           +  +  GVKL++    +  ++EQTT  NVYAIGD+    P+LTPVAIQAGR L+RRL+  
Sbjct: 400 VLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAG 459

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            T   DY  + T VFTP+EYG CGLSEED+ E+YGD  +EVYH NF PLEW++A +    
Sbjct: 460 ATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHR---E 516

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              CY+K+VC K+ N  VLG H LGPNAGE+TQ   +A+K+G T      T+GIHP
Sbjct: 517 DNVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHP 572


>ref|XP_002010389.1| GI15898 [Drosophila mojavensis]
 gb|EDW07706.1| GI15898 [Drosophila mojavensis]
          Length = 601

 Score =  443 bits (1140), Expect = e-122
 Identities = 246/471 (52%), Positives = 316/471 (67%), Gaps = 17/471 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGL+C+KEA + G +V  LD+VKP+P GT WG+GGTCVNVGCIPKKL
Sbjct: 118 NYDYDLVVIGGGSGGLSCAKEAVAHGARVACLDFVKPTPLGTKWGVGGTCVNVGCIPKKL 177

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+GE + H+ A++GWNV          DW +LV+ V            V+LR K+
Sbjct: 178 MHQAALLGEAV-HEAAAYGWNVDDKIKP----DWSKLVTAVQNHIKSVNWVTRVDLRDKK 232

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LGSFVD HT+     K G + IT +  VIAVGGRPR     G  E  ++SDD+F
Sbjct: 233 VEYINGLGSFVDSHTISA-KLKGGERTITAQTFVIAVGGRPRYPNIPGAVEYGITSDDLF 291

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +   EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA+ +   ME +
Sbjct: 292 SL-DHEPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAAAME-E 349

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            GI F+RKTVP S+ K   G+LLVK+  TE G+   + FDTVL A GR   V  L LD A
Sbjct: 350 RGIPFLRKTVPLSVEKQSDGRLLVKYENTETGEVDSDVFDTVLWAIGRKGLVDDLNLDNA 409

Query: 299 GVKLNEKTGRIWVNNEQTT-TPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV  ++   +I V+ E+TT  P++YA+GD+I   PELTPVA+ AGRLL+RRLY +  ++M
Sbjct: 410 GVLTHK--DKIQVDCEETTNVPHIYAVGDIIYGKPELTPVAVLAGRLLARRLYADSELRM 467

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY  + T VFTP+EY C GLSEED+ + YG + +EV+H  + P E+ + ++   +   CY
Sbjct: 468 DYVDVATTVFTPLEYACVGLSEEDAIKLYGAEEIEVFHGYYKPTEFFIPQK---SVRYCY 524

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           VK V  +     V G HYLGP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 525 VKAVAQRNGEQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHP 575


>emb|CAF96941.1| unnamed protein product [Tetraodon nigroviridis]
          Length = 629

 Score =  443 bits (1140), Expect = e-122
 Identities = 246/503 (48%), Positives = 314/503 (62%), Gaps = 46/503 (9%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGLACSKEAA  GKKV VLDYV P+P GTSWGLGGTCVNVGCIPKKL
Sbjct: 113 AYDYDLIVIGGGSGGLACSKEAALLGKKVMVLDYVVPTPKGTSWGLGGTCVNVGCIPKKL 172

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+   +  D   FGW       +  T +W+ + + +            V LR K 
Sbjct: 173 MHQTALLRTAI-QDARKFGWEF----DEAVTHNWETMKTAINDYIGSLNWGYRVSLRDKN 227

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N    FVDPH +K  + +      T    V+A G RPR L   G  E  ++SDD+F
Sbjct: 228 VNYVNAYAEFVDPHKIKATNKRGKETFYTAARFVLATGERPRYLGVPGDKEYCITSDDLF 287

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLV+GASYVALEC GFL G+G  V VMVRSILLRGFDQDMA++ G+YME +
Sbjct: 288 SLPYC-PGKTLVIGASYVALECGGFLAGLGLDVTVMVRSILLRGFDQDMANRAGQYME-E 345

Query: 240 SGIEFIRKTVPQSI----TKLDSGQLLVKWI----------------------------- 266
            G++F+RK VP  +     +   G  LV  +                             
Sbjct: 346 HGVKFLRKYVPVQVGGPRKRAGVGARLVLHVQKSSSLTSVWQIEELEAGTPGRLKVTAKS 405

Query: 267 TEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIG 325
           TE  +  EE ++TVL A GR+    K+GLD+ GVK+N K G+I VN+ EQT+ P++YAIG
Sbjct: 406 TESDEIIEEEYNTVLIAVGRNACTDKIGLDKVGVKVNPKNGKIPVNDEEQTSVPHIYAIG 465

Query: 326 DVIDAP-ELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEE 384
           D+++   ELTPVAIQAGRLL+RRLY    V+ DY  + T VFTP+EYG CGLSEE +   
Sbjct: 466 DILEEKWELTPVAIQAGRLLARRLYGGSKVKCDYVNVPTTVFTPMEYGACGLSEERAVGL 525

Query: 385 YGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQ 444
           YG +++EV+H  F PLE+++  +       CY K++C+K  +  V+GFHYLGPNAGEVTQ
Sbjct: 526 YGQENIEVFHTQFWPLEFTVPGRDN---NKCYAKIICNKLDSGRVVGFHYLGPNAGEVTQ 582

Query: 445 AMGLAMKLGFTYDQLVDTVGIHP 467
               AMK G T +QL  T+GIHP
Sbjct: 583 GFSAAMKCGATKEQLDGTIGIHP 605


>sp|B9A1H3|TRXR1_EMIHU RecName: Full=Thioredoxin reductase SEP1; Short=EhSEP1
 dbj|BAH20464.1| thioredoxin reductase [Emiliania huxleyi]
          Length = 495

 Score =  443 bits (1139), Expect = e-122
 Identities = 239/474 (50%), Positives = 302/474 (63%), Gaps = 22/474 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLACSK AAS GKKV V D+VKPSP GT+WGLGGTCVNVGCIPKKLMHQ
Sbjct: 8   YDLLVIGGGSGGLACSKRAASHGKKVAVCDFVKPSPPGTTWGLGGTCVNVGCIPKKLMHQ 67

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+GE +  D  SFGW V +     P  +W+ +V NV             +L S  VKY
Sbjct: 68  AALLGEGM-TDAESFGWEVAA-----PKHNWETMVGNVQGHIKSLNFGYRSDLMSNGVKY 121

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWMK 182
            N   +F+DPHT++    K    +IT   +VI  GGRPR     G  EL ++SDD+F +K
Sbjct: 122 YNAYATFLDPHTVEAVDKKGKVTKITASEIVICTGGRPRYPDIPGAKELGITSDDVFALK 181

Query: 183 QKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSGI 242
              PG+TLVVGASYVALECAGF+KG+GY   VM+RSI LRGFDQ MA     YM+ + G+
Sbjct: 182 -SPPGRTLVVGASYVALECAGFIKGVGYDTTVMMRSIPLRGFDQQMAGLCKTYMQ-EHGV 239

Query: 243 EFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKL 302
            FI   VP ++    SG   V W   DG      +DTVL A GRD   + +G+D+AGVKL
Sbjct: 240 AFIEGAVPTAVEATPSGAKKVSWKLADGSVGSGEYDTVLFAIGRDVCTSAIGIDKAGVKL 299

Query: 303 NEKTGRIWVNNEQTTTPNVYAIGDVID---------APELTPVAIQAGRLLSRRLYNEGT 353
           +   G++   NEQT  P++YAIGD+ID           ELTPVAIQAG+LL+ RLY   +
Sbjct: 300 S-SNGKVPTVNEQTNVPHIYAIGDIIDGEALNPPSATTELTPVAIQAGKLLADRLYAGKS 358

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDY  + T V+TP+EYG  GL EE++ + +G+D++EVYH  F PLEW+L  +      
Sbjct: 359 ALMDYSMVATTVYTPLEYGAVGLPEEEAIKLHGEDNIEVYHSYFKPLEWTLPHR---GDN 415

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C K     V+G H  GPNAGE+TQ   +A+K G T     DTVGIHP
Sbjct: 416 VCYAKLICLKPEGERVIGLHVCGPNAGEMTQGFAVAIKAGATKAHFDDTVGIHP 469


>ref|XP_001847793.1| thioredoxin reductase 1, mitochondrial [Culex quinquefasciatus]
 gb|EDS26956.1| thioredoxin reductase 1, mitochondrial [Culex quinquefasciatus]
          Length = 536

 Score =  443 bits (1139), Expect = e-122
 Identities = 243/472 (51%), Positives = 311/472 (65%), Gaps = 13/472 (2%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGLAC+KEA  FG KV VLD+V PSP GT WGLGGTCVNVGCIPKKL
Sbjct: 47  NYDYDLVVIGGGSGGLACAKEAIQFGAKVAVLDFVVPSPRGTKWGLGGTCVNVGCIPKKL 106

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + HD   +GW            DW  L  +V            V+LR K+
Sbjct: 107 MHQASLLGEAI-HDSQPYGWKFAEPAS--VKHDWATLTESVQNHIKSVNWVTRVDLRDKK 163

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N  G F D H +      K  + ++T++VVIAVGGRPR     G  E  ++SDDIF
Sbjct: 164 VEYVNGFGYFKDAHNVVAVMKNKTERVLSTKYVVIAVGGRPRYPNIPGAEEYGITSDDIF 223

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            + Q EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSILLRGFDQ MA+ +G+ M ++
Sbjct: 224 SLPQ-EPGKTLVVGAGYIGLECAGFLKGLGYDATVMVRSILLRGFDQQMATMVGDAM-VE 281

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAG 299
            GI+F+ KT P S+ K + G+LLVK+ +++G    + +DTVL A GR      L LD+AG
Sbjct: 282 KGIKFMHKTQPTSVEKQEDGRLLVKYASDEGVEGSDVYDTVLFAIGRTACTKDLKLDQAG 341

Query: 300 VKLNE--KTGRIWVN-NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           +   E  K+ ++ V   EQT   NV+A+GDV+   PELTPVAI AGRLL+RRL+N  +  
Sbjct: 342 IVTAEGNKSDKLDVTVQEQTNVDNVFAVGDVLYKKPELTPVAIHAGRLLARRLFNNQSDV 401

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VF+P+EYGC GLSEED++ +YG ++VEVYH  + P E+ + ++   +   C
Sbjct: 402 MDYTDVATTVFSPLEYGCVGLSEEDAEAKYGKENVEVYHAYYKPTEFFVPQR---SVRYC 458

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V     +  VLG H+LGP AGEV Q    A+K G T   L +TVGIHP
Sbjct: 459 YLKAVALLEGDQKVLGLHFLGPAAGEVIQGFAAAVKSGLTMKILKNTVGIHP 510


>ref|XP_001662666.1| thioredoxin reductase [Aedes aegypti]
 gb|EAT45854.1| thioredoxin reductase [Aedes aegypti]
          Length = 521

 Score =  443 bits (1139), Expect = e-122
 Identities = 243/472 (51%), Positives = 312/472 (66%), Gaps = 13/472 (2%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDLVVIGGGSGGLAC+KEA  FG KV VLD+VKPSP GT WGLGGTCVNVGCIPKKL
Sbjct: 32  NFDYDLVVIGGGSGGLACAKEAVQFGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKL 91

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + HD   +GW       +    DW  L  +V            V+LR K+
Sbjct: 92  MHQASLLGEAI-HDAQPYGWKF--AEPESVKHDWATLTESVQNHIKSVNWVTRVDLRDKK 148

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LG F D H +      +  + + T++VVIAVGGRPR     G  E  ++SDDIF
Sbjct: 149 VEYVNGLGYFKDAHNVVAVMKNQTERVLNTKNVVIAVGGRPRYPNIPGALEHGITSDDIF 208

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +   EPGKTLVVGA Y+ LECAGFLKG GY   VMVRSILLRGFDQ MA+ +G+ M ++
Sbjct: 209 SLPH-EPGKTLVVGAGYIGLECAGFLKGFGYDATVMVRSILLRGFDQQMATMVGDAM-VE 266

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAG 299
            GI+F+ KT PQS+ K   G+LLVK+ ++DG    + +DTVL A GR      L LD+AG
Sbjct: 267 KGIKFLHKTQPQSVEKQADGRLLVKYRSDDGTEGSDVYDTVLFAIGRTACTDDLKLDQAG 326

Query: 300 VKLNE--KTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           V   E  K+ ++ V++ E T  PN++A+GDV+   PELTPVAI AGRLL+RRL+N  T  
Sbjct: 327 VVTAEGGKSDKLDVDSFETTNVPNIFAVGDVLYKRPELTPVAIHAGRLLARRLFNNQTDI 386

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VF+P+EYGC G+SEE+++ ++G D VEVYH  + P E+ + ++   +   C
Sbjct: 387 MDYADVATTVFSPLEYGCVGMSEENAEAKFGKDKVEVYHAYYKPTEFFVPQR---SVRYC 443

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V     +  VLG H+LGP AGEV Q    A+K G T   L +TVGIHP
Sbjct: 444 YLKAVALLEGDQKVLGLHFLGPVAGEVIQGFAAALKSGLTMKILKNTVGIHP 495


>ref|XP_001662665.1| thioredoxin reductase [Aedes aegypti]
 gb|EAT45853.1| thioredoxin reductase [Aedes aegypti]
          Length = 497

 Score =  443 bits (1139), Expect = e-122
 Identities = 243/472 (51%), Positives = 312/472 (66%), Gaps = 13/472 (2%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDLVVIGGGSGGLAC+KEA  FG KV VLD+VKPSP GT WGLGGTCVNVGCIPKKL
Sbjct: 8   NFDYDLVVIGGGSGGLACAKEAVQFGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKL 67

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + HD   +GW       +    DW  L  +V            V+LR K+
Sbjct: 68  MHQASLLGEAI-HDAQPYGWKF--AEPESVKHDWATLTESVQNHIKSVNWVTRVDLRDKK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LG F D H +      +  + + T++VVIAVGGRPR     G  E  ++SDDIF
Sbjct: 125 VEYVNGLGYFKDAHNVVAVMKNQTERVLNTKNVVIAVGGRPRYPNIPGALEHGITSDDIF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +   EPGKTLVVGA Y+ LECAGFLKG GY   VMVRSILLRGFDQ MA+ +G+ M ++
Sbjct: 185 SLPH-EPGKTLVVGAGYIGLECAGFLKGFGYDATVMVRSILLRGFDQQMATMVGDAM-VE 242

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAG 299
            GI+F+ KT PQS+ K   G+LLVK+ ++DG    + +DTVL A GR      L LD+AG
Sbjct: 243 KGIKFLHKTQPQSVEKQADGRLLVKYRSDDGTEGSDVYDTVLFAIGRTACTDDLKLDQAG 302

Query: 300 VKLNE--KTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           V   E  K+ ++ V++ E T  PN++A+GDV+   PELTPVAI AGRLL+RRL+N  T  
Sbjct: 303 VVTAEGGKSDKLDVDSFETTNVPNIFAVGDVLYKRPELTPVAIHAGRLLARRLFNNQTDI 362

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VF+P+EYGC G+SEE+++ ++G D VEVYH  + P E+ + ++   +   C
Sbjct: 363 MDYADVATTVFSPLEYGCVGMSEENAEAKFGKDKVEVYHAYYKPTEFFVPQR---SVRYC 419

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V     +  VLG H+LGP AGEV Q    A+K G T   L +TVGIHP
Sbjct: 420 YLKAVALLEGDQKVLGLHFLGPVAGEVIQGFAAALKSGLTMKILKNTVGIHP 471


>gb|AAC69637.1| glutathione reductase family member [Musca domestica]
          Length = 495

 Score =  442 bits (1138), Expect = e-122
 Identities = 237/470 (50%), Positives = 317/470 (67%), Gaps = 14/470 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGGLAC+KEA + G KV  LDYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 10  YDYDLIVIGGGSGGLACAKEAVANGAKVACLDYVKPTPLGTKWGIGGTCVNVGCIPKKLM 69

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GW + +     P   W+ LV  V            V+LR K+V
Sbjct: 70  HQASLLGESI-HEATAYGWEIPNKEAIKP--KWENLVQAVQNHIKSVNWVTRVDLRDKKV 126

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           +Y N  GSF DPHT+         + +T R+VVIAVGGRPR     G  E  ++SDD+F 
Sbjct: 127 EYINGAGSFKDPHTVVAKMKNGSERTLTGRNVVIAVGGRPRYPDIPGAVEYGITSDDLFS 186

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +  KEPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA+ + + M ++ 
Sbjct: 187 L-DKEPGKTLVVGAGYIGLECAGFLKGLGYDATVMVRSIVLRGFDQQMANMVADSM-VER 244

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWI-TEDGDCFEETFDTVLNATGRDPDVAKLGLDEAG 299
           GI F+ KT+P+S+ K   G+LLVK++ TE  +   + +DTVL A GR   V  L L  AG
Sbjct: 245 GIPFLHKTIPKSVEKTQDGRLLVKYVNTETQEEGSDVYDTVLWAIGRKGLVDDLNLGAAG 304

Query: 300 VKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           +++  K  +I VN  EQT  P+++A+GD+I   PELTPVAI AGRLL+RRL+      MD
Sbjct: 305 IEV--KADKIAVNEAEQTNVPHIFAVGDIIHGRPELTPVAIHAGRLLARRLFGGSKQIMD 362

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYV 417
           Y  + T VF+P+EY C G++EED+ +++G+D++EV+H  + P E+ + ++   +   CYV
Sbjct: 363 YTDVATTVFSPLEYACVGMAEEDAIQKFGEDNIEVFHGFYKPTEFFIPQK---SVRYCYV 419

Query: 418 KVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           K V +++ +  VLG HYLGP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 420 KAVAERSGDQKVLGLHYLGPVAGEVIQGFAAAVKSGLTMKILLNTVGIHP 469


>gb|ADD18525.1| thioredoxin reductase-1 [Glossina morsitans morsitans]
          Length = 499

 Score =  441 bits (1135), Expect = e-122
 Identities = 231/469 (49%), Positives = 313/469 (66%), Gaps = 13/469 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y YDL+VIGGGSGGLAC+KEA   G KV  LD+VKP+PHG+ WGLGGTCVNVGC+PKKLM
Sbjct: 15  YGYDLIVIGGGSGGLACAKEAIVNGAKVACLDFVKPTPHGSKWGLGGTCVNVGCVPKKLM 74

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE L  D  ++GW +       P  DW +LV +V            V+LR K++
Sbjct: 75  HQASLLGEAL-SDAQAYGWEIPDAKNIKP--DWGKLVQSVQNHIKSVNWVTRVDLRDKKI 131

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGELAVSSDDIFWM 181
           +Y N LGSF D HT+ +       + ++ R++VIAVGGRPR     G EL ++SDD+F +
Sbjct: 132 EYLNGLGSFRDSHTILVKMKNNTERTVSARNIVIAVGGRPRYPNIPGAELGITSDDLFSL 191

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
             K PG+TL+VGA Y+ LECAGFL+G+GY   VMVRSI+LRGFDQ MA+ + + M ++ G
Sbjct: 192 -DKPPGRTLIVGAGYIGLECAGFLRGLGYDATVMVRSIILRGFDQQMANMVADSM-VERG 249

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           ++FI KT+P+S+ K      LVK+I  E  +   + +DTV+ A GR   +  L L   G+
Sbjct: 250 VKFIHKTIPKSVEKTGHNTYLVKYINIETKEEGSDEYDTVMWAIGRKGLLEDLNLTSIGI 309

Query: 301 KLNEKTGRIWVNN-EQTTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNEGTVQMDY 358
           +L  K  +I VN+ EQT   NVYA+GD+    PELTPVAI AGRLL+RRL+   T  MDY
Sbjct: 310 EL--KNDKILVNDAEQTNVSNVYAVGDITYGRPELTPVAIHAGRLLARRLFGNSTQLMDY 367

Query: 359 DKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVK 418
             + T VF+P+EY C G+SEED+ +EYG+D++EV+H  + P E+ + ++   +   CYVK
Sbjct: 368 CNVATTVFSPLEYACVGMSEEDAAQEYGEDNIEVFHGFYKPTEFFIPQK---SVRYCYVK 424

Query: 419 VVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            V +++ +  VLG HYLGP AGE+ Q    A+K G T   L++TVGIHP
Sbjct: 425 AVAERSGDQRVLGLHYLGPVAGEIIQGFAAAVKCGLTMKILMNTVGIHP 473


>ref|XP_002722800.1| PREDICTED: thioredoxin reductase 2-like [Oryctolagus cuniculus]
          Length = 491

 Score =  441 bits (1134), Expect = e-121
 Identities = 235/471 (49%), Positives = 309/471 (65%), Gaps = 19/471 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA  G+KV VLDYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 9   YDLLVIGGGSGGLACAKEAAQLGRKVAVLDYVEPSPRGTRWGLGGTCVNVGCIPKKLMHQ 68

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G  +  D   +GW V     Q    DW ++   +            V+L+ ++VKY
Sbjct: 69  AALLGGAI-RDAGRYGWEV----AQPARHDWSKMAEAIQNHVRSLNWGHRVQLQERKVKY 123

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIFWM 181
            NV   F+D HT+      K    ++  H+VIA GGRPR    + G  E  ++SDDIFW+
Sbjct: 124 LNVKARFIDKHTVLGVSKDKKETLLSADHIVIATGGRPRYPTLIQGASEYGITSDDIFWL 183

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
           K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ MAS + ++M    G
Sbjct: 184 KE-SPGKTLVVGASYVALECAGFLTGLGLDTTIMIRSIPLRGFDQQMASLVTDHM-ASHG 241

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLDEA 298
              +R   P  + +L  G+L V W  ED  C +E    F+TVL A GR P+   L L+ A
Sbjct: 242 TRILRGCTPSRVARLPDGRLQVTW--EDRTCGKEDSGVFNTVLWAIGRVPETRGLNLEGA 299

Query: 299 GVKLNEKTGRIWVNNEQTTT-PNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV+ N ++ +I V+   TT+ P++YAIGDV +  PELTP AI AG+LL++RL+   +  M
Sbjct: 300 GVETNPESQKILVDARDTTSVPHIYAIGDVAEGRPELTPTAIMAGKLLAQRLFGGSSDLM 359

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY  + T VFTP+EYGC GLSEE++   +G + +EVYH  + PLE+++AEQ    A  CY
Sbjct: 360 DYSNVPTTVFTPLEYGCVGLSEEEAVARHGQEQIEVYHAYYKPLEFTVAEQD---ASQCY 416

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y+Q++ TVGIHP
Sbjct: 417 IKMVCLRQPPQPVLGLHFLGPNAGEVTQGFALGIKCGASYEQVIRTVGIHP 467


>ref|XP_001977919.1| GG19308 [Drosophila erecta]
 gb|EDV46846.1| GG19308 [Drosophila erecta]
          Length = 491

 Score =  441 bits (1134), Expect = e-121
 Identities = 246/472 (52%), Positives = 320/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LDYVKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDYVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV   N ++   DW +LV +V            V+LR K
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNV---NEKIKP-DWNKLVQSVQNHIKSVNWVTRVDLRDK 121

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 122 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 181 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 238

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RK+VP S+ K D G+LLVK+   E  +  E+ FDTVL A GR   V  L L  
Sbjct: 239 ERGIPFLRKSVPLSVQKQDDGKLLVKYKNVETDEEAEDVFDTVLWAIGRKGLVDDLNLPN 298

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 299 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGATQR 356

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY+ + T VFTP+EY C GLSEE++ ++YG D +EV+H  + P E+ + ++   +   C
Sbjct: 357 MDYNDVATTVFTPLEYACVGLSEEEAVKQYGADEIEVFHGYYKPTEFFIPQK---SVRYC 413

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 414 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 465


>gb|ACH86016.1| thioredoxin glutathione reductase [Schistosoma japonicum]
          Length = 596

 Score =  440 bits (1132), Expect = e-121
 Identities = 236/476 (49%), Positives = 304/476 (63%), Gaps = 19/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL++IGGGSGGLA  KEAA +G K+ VLDYV+P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 106 YDYDLIIIGGGSGGLAAGKEAAKYGAKIAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLM 165

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+   L  D   FGW   S++    + DW  +V  V            V LR   V
Sbjct: 166 HQAGLLSHSL-EDAQHFGW---SLDKSEISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAV 221

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G  + PH +++    K    IT   +++A   RP+     G  E  ++SDD+F 
Sbjct: 222 TYLNARGMLLSPHEVQITEKNKKVSTITGNKIILATVERPKYPEIPGAIEYGITSDDLFS 281

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVAL+CAGFL  +G  V VMVRSILLRGFDQ MA K+G+YME   
Sbjct: 282 LPY-FPGKTLVVGASYVALKCAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYME-NH 339

Query: 241 GIEFIRKTVPQSITKL--------DSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAK 292
           G++F +  VP  IT+L          G LLVK    DG  FEE F+TV+ A GR+P ++K
Sbjct: 340 GVKFAKLCVPDEITQLKPVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSK 399

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNE 351
           L  +  GVKL++    +  ++EQTT  N+YAIGD+    P+LTPVAI AGR L+RRL+  
Sbjct: 400 LNCEAVGVKLDKNGRVVCSDDEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAG 459

Query: 352 GTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIA 411
            T   DY  + T VFTP+EYG CGLSEED+ E+YGD+ +EVYH +F PLEW++A +    
Sbjct: 460 ATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVAHR---E 516

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              CY+K+VC  + N  VLG H LGPNAGE+TQ   +A+K+G T +    T+GIHP
Sbjct: 517 DNVCYMKLVCRISDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHP 572


>pdb|3DH9|A Chain A, Crystal Structure Of Drosophila Thioredoxin Reductase,
           Wild- Type
 pdb|3DH9|B Chain B, Crystal Structure Of Drosophila Thioredoxin Reductase,
           Wild- Type
          Length = 482

 Score =  440 bits (1131), Expect = e-121
 Identities = 245/472 (51%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 3   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 62

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 63  LMHQASLLGEAVH-EAAAYGWNVDDKIKP----DWHKLVQSVQNHIKSVNWVTRVDLRDK 117

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 118 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 176

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 177 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 234

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K D G+LLVK+   E G+  E+ +DTVL A GR   V  L L  
Sbjct: 235 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPN 294

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 295 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQR 352

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +++G D +EV+H  + P E+ + ++   +   C
Sbjct: 353 MDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQK---SVRYC 409

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 410 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 461


>pdb|3DGH|A Chain A, Crystal Structure Of Drosophila Thioredoxin Reductase, C-
           Terminal 8-Residue Truncation
 pdb|3DGH|B Chain B, Crystal Structure Of Drosophila Thioredoxin Reductase, C-
           Terminal 8-Residue Truncation
          Length = 483

 Score =  440 bits (1131), Expect = e-121
 Identities = 245/472 (51%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDDKIKP----DWHKLVQSVQNHIKSVNWVTRVDLRDK 121

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 122 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 181 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 238

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K D G+LLVK+   E G+  E+ +DTVL A GR   V  L L  
Sbjct: 239 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPN 298

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 299 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQR 356

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +++G D +EV+H  + P E+ + ++   +   C
Sbjct: 357 MDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQK---SVRYC 413

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 414 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 465


>ref|XP_001603220.1| PREDICTED: similar to thioredoxin reductase [Nasonia vitripennis]
          Length = 539

 Score =  440 bits (1131), Expect = e-121
 Identities = 232/468 (49%), Positives = 302/468 (64%), Gaps = 10/468 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y YDLVV+GGGSGGLA +K+A   G KV V DYV PSP GT WGLGGTCVNVGCIPKKLM
Sbjct: 54  YQYDLVVLGGGSGGLAAAKQATELGAKVAVFDYVIPSPQGTKWGLGGTCVNVGCIPKKLM 113

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+GE + H+  +FGW +  V       DW+ L + V            VELR+K+V
Sbjct: 114 HQAALLGEAV-HEATAFGWQIPEVKS--VKIDWEALTTAVQNHVKSVNWVTRVELRNKKV 170

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           +Y N LG F DPHT+         K +T ++V+IAVGGRP      G  E  ++SDDIF 
Sbjct: 171 EYINALGYFKDPHTIGGIMKNGEEKVVTAKNVLIAVGGRPNYPDIPGAVEYGITSDDIFS 230

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +  K PGKTLVVGA Y+ LECAGFL G+GY   +MVRSI+LRGFDQ MA+ I E ME + 
Sbjct: 231 L-SKPPGKTLVVGAGYIGLECAGFLNGLGYDATIMVRSIILRGFDQQMANIIAEEMETR- 288

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           G+ FI +  P+++ K   G +LV W+ +DG   ++ +DTVL A GR      L L+ AGV
Sbjct: 289 GVHFIYQAKPKALEKQADGSILVHWVDKDGQIHKDVYDTVLFAIGRKALTKDLKLENAGV 348

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
            +  +  +I   NEQT  P+VYA+GDV+   PELTPVAI AG+LL++RLY   T  MDY 
Sbjct: 349 FVVPENEKIDALNEQTNVPHVYAVGDVLHKKPELTPVAIHAGKLLAKRLYGNATELMDYT 408

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKV 419
            + T VF+P+EYGC GLSEE +   +G+DS+E+YH  + P E+ + ++       CY+KV
Sbjct: 409 NVATTVFSPLEYGCVGLSEEQAIAIHGEDSIEIYHAYYKPTEFFVPQKDN---SRCYLKV 465

Query: 420 VCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           V  +  +  VLG H++GPNAGEV Q    A+K   T+  L  TVGIHP
Sbjct: 466 VALRNNDQKVLGLHFVGPNAGEVIQGFATAIKCNLTFPLLKSTVGIHP 513


>pdb|2NVK|X Chain X, Crystal Structure Of Thioredoxin Reductase From Drosophila
           Melanogaster
          Length = 488

 Score =  440 bits (1131), Expect = e-121
 Identities = 245/472 (51%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDDKIKP----DWHKLVQSVQNHIKSVNWVTRVDLRDK 121

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 122 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 181 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 238

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K D G+LLVK+   E G+  E+ +DTVL A GR   V  L L  
Sbjct: 239 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPN 298

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 299 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQR 356

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +++G D +EV+H  + P E+ + ++   +   C
Sbjct: 357 MDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQK---SVRYC 413

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 414 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 465


>gb|AAG25640.1|AF301145_1 thioredoxin reductase-1 splice variant [Drosophila melanogaster]
          Length = 491

 Score =  440 bits (1131), Expect = e-121
 Identities = 245/472 (51%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDEKIKP----DWHKLVQSVQNHIKSVNWVTRVDLRDK 121

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 122 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 181 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 238

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K D G+LLVK+   E G+  E+ +DTVL A GR   V  L L  
Sbjct: 239 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPN 298

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 299 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQR 356

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +++G D +EV+H  + P E+ + ++   +   C
Sbjct: 357 MDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQK---SVRYC 413

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 414 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 465


>ref|NP_727251.1| thioredoxin reductase-1, isoform B [Drosophila melanogaster]
 sp|P91938|TRXR1_DROME RecName: Full=Thioredoxin reductase 1, mitochondrial; Short=TrxR-1;
           Flags: Precursor
 gb|AAF46355.2| thioredoxin reductase-1, isoform B [Drosophila melanogaster]
          Length = 596

 Score =  440 bits (1131), Expect = e-121
 Identities = 245/472 (51%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 112 SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 171

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 172 LMHQASLLGEAVH-EAAAYGWNVDEKIKP----DWHKLVQSVQNHIKSVNWVTRVDLRDK 226

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 227 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 285

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 286 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 343

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K D G+LLVK+   E G+  E+ +DTVL A GR   V  L L  
Sbjct: 344 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPN 403

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 404 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQR 461

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +++G D +EV+H  + P E+ + ++   +   C
Sbjct: 462 MDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQK---SVRYC 518

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 519 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 570


>ref|NP_511082.2| thioredoxin reductase-1, isoform A [Drosophila melanogaster]
 gb|AAG25639.1|AF301144_1 thioredoxin reductase-1 [Drosophila melanogaster]
 gb|AAF46354.1| thioredoxin reductase-1, isoform A [Drosophila melanogaster]
 gb|AAO25023.1| LD21729p [Drosophila melanogaster]
 gb|ACL84476.1| Trxr-1-PA [synthetic construct]
 gb|ACL89485.1| Trxr-1-PA [synthetic construct]
          Length = 491

 Score =  440 bits (1131), Expect = e-121
 Identities = 245/472 (51%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 7   SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 66

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 67  LMHQASLLGEAVH-EAAAYGWNVDEKIKP----DWHKLVQSVQNHIKSVNWVTRVDLRDK 121

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 122 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 181 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 238

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K D G+LLVK+   E G+  E+ +DTVL A GR   V  L L  
Sbjct: 239 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPN 298

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 299 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQR 356

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +++G D +EV+H  + P E+ + ++   +   C
Sbjct: 357 MDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQK---SVRYC 413

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 414 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 465


>ref|NP_727252.1| thioredoxin reductase-1, isoform C [Drosophila melanogaster]
 gb|AAN09228.1| thioredoxin reductase-1, isoform C [Drosophila melanogaster]
 gb|ABE73241.1| IP15366p [Drosophila melanogaster]
          Length = 508

 Score =  440 bits (1131), Expect = e-121
 Identities = 245/472 (51%), Positives = 317/472 (67%), Gaps = 18/472 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPH-GTSWGLGGTCVNVGCIPKK 59
           SYDYDL+VIGGGS GLAC+KEA   G +V  LD+VKP+P  GT WG+GGTCVNVGCIPKK
Sbjct: 24  SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 83

Query: 60  LMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           LMHQ+SL+GE +H + A++GWNV          DW +LV +V            V+LR K
Sbjct: 84  LMHQASLLGEAVH-EAAAYGWNVDEKIKP----DWHKLVQSVQNHIKSVNWVTRVDLRDK 138

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +V+Y N LGSFVD HTL L   K G + IT +  VIAVGGRPR     G  E  ++SDD+
Sbjct: 139 KVEYINGLGSFVDSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDL 197

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  +EPGKTLVVGA Y+ LECAGFLKG+GY   VMVRSI+LRGFDQ MA  +   ME 
Sbjct: 198 FSL-DREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASME- 255

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWIT-EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + GI F+RKTVP S+ K D G+LLVK+   E G+  E+ +DTVL A GR   V  L L  
Sbjct: 256 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPN 315

Query: 298 AGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV + +   +I V++++ T   N+YA+GD+I   PELTPVA+ AGRLL+RRLY   T +
Sbjct: 316 AGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQR 373

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY  + T VFTP+EY C GLSEED+ +++G D +EV+H  + P E+ + ++   +   C
Sbjct: 374 MDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQK---SVRYC 430

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K V ++  +  V G HY+GP AGEV Q    A+K G T + L++TVGIHP
Sbjct: 431 YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHP 482


>ref|XP_002697197.1| PREDICTED: thioredoxin reductase 3 [Bos taurus]
 gb|DAA16756.1| thioredoxin reductase 3 [Bos taurus]
          Length = 790

 Score =  439 bits (1130), Expect = e-121
 Identities = 239/474 (50%), Positives = 309/474 (65%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGL+C++EAA  G+KV VLD+V PSP GT+WGLGGTCVNVGCIPKKL
Sbjct: 303 AYDYDLIVIGGGSGGLSCAQEAAVLGRKVMVLDFVVPSPRGTAWGLGGTCVNVGCIPKKL 362

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       Q     W  +   +            + LR K 
Sbjct: 363 MHQAALLGQAL-TDSRKFGWEY----SQQVRHSWATMTEAIQSHIGSLSWGHRLALREKA 417

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 418 VTYVNSFGEFVEHHKVKATNEKGQEVLYTAAKFVIATGERPRYLGIPGDREYCITSDDLF 477

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TLVVGASYVALECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G  M+ Q
Sbjct: 478 SLPYC-PGATLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGASMQ-Q 535

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G+ F+RK VP  + +L+ G      +V   TE  +  E  ++TVL A GRD    KLGL
Sbjct: 536 LGVRFLRKFVPVEVQQLERGLPGRLKVVAKSTEGTETIEGIYNTVLLAIGRDSCTKKLGL 595

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GV ++EKTG+I VN+ EQT+   VYA+GDV++  P+LTPVA+QAG+LL+RRL+   +
Sbjct: 596 EKIGVNVSEKTGKIPVNDEEQTSVSYVYAVGDVLEGKPQLTPVAVQAGKLLARRLFGGRS 655

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCG SEE + E Y  +++ VYH  F PLEW++A +      
Sbjct: 656 EKCDYVNVPTVVFTPLEYGCCGYSEEKAGEVYQAENLNVYHTLFWPLEWTVAGRDN---N 712

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N+ V+GFH LGPNAGE+TQ    AMK G T   L DT+GIHP
Sbjct: 713 TCYAKIICNKLDNDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHP 766


>ref|NP_001179038.1| thioredoxin reductase 3 [Bos taurus]
          Length = 578

 Score =  439 bits (1130), Expect = e-121
 Identities = 239/474 (50%), Positives = 309/474 (65%), Gaps = 17/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL+VIGGGSGGL+C++EAA  G+KV VLD+V PSP GT+WGLGGTCVNVGCIPKKL
Sbjct: 91  AYDYDLIVIGGGSGGLSCAQEAAVLGRKVMVLDFVVPSPRGTAWGLGGTCVNVGCIPKKL 150

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       Q     W  +   +            + LR K 
Sbjct: 151 MHQAALLGQAL-TDSRKFGWEY----SQQVRHSWATMTEAIQSHIGSLSWGHRLALREKA 205

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 206 VTYVNSFGEFVEHHKVKATNEKGQEVLYTAAKFVIATGERPRYLGIPGDREYCITSDDLF 265

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PG TLVVGASYVALECAGFL G+G  V VMVRS+LLRGFDQ+MA K+G  M+ Q
Sbjct: 266 SLPYC-PGATLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGASMQ-Q 323

Query: 240 SGIEFIRKTVPQSITKLDSG----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G+ F+RK VP  + +L+ G      +V   TE  +  E  ++TVL A GRD    KLGL
Sbjct: 324 LGVRFLRKFVPVEVQQLERGLPGRLKVVAKSTEGTETIEGIYNTVLLAIGRDSCTKKLGL 383

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++ GV ++EKTG+I VN+ EQT+   VYA+GDV++  P+LTPVA+QAG+LL+RRL+   +
Sbjct: 384 EKIGVNVSEKTGKIPVNDEEQTSVSYVYAVGDVLEGKPQLTPVAVQAGKLLARRLFGGRS 443

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
            + DY  + T VFTP+EYGCCG SEE + E Y  +++ VYH  F PLEW++A +      
Sbjct: 444 EKCDYVNVPTVVFTPLEYGCCGYSEEKAGEVYQAENLNVYHTLFWPLEWTVAGRDN---N 500

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +CY K++C+K  N+ V+GFH LGPNAGE+TQ    AMK G T   L DT+GIHP
Sbjct: 501 TCYAKIICNKLDNDRVIGFHVLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHP 554


>gb|EDL77943.1| thioredoxin reductase 2, isoform CRA_a [Rattus norvegicus]
          Length = 524

 Score =  439 bits (1129), Expect = e-121
 Identities = 235/472 (49%), Positives = 315/472 (66%), Gaps = 19/472 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL+VIGGGSGGLAC+KEAA  G+KV V DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 41  NFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 100

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VK
Sbjct: 101 QAALLGGMI-RDAQHYGWEV----AQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVK 155

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGEL--AVSSDDIFW 180
           Y N+  SFV+ HT+          +++ +H+VIA GGRP+    + G L   ++SDDIFW
Sbjct: 156 YFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFW 215

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +K+  PGKTLVVGASYVALECAGFL G+G    VM+RS+ LRGFDQ MAS + E+ME   
Sbjct: 216 LKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHME-SH 273

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLDE 297
           G  F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L++
Sbjct: 274 GTRFLKGCVPSLIRKLPTNQLQVTW--EDLASGKEDVGTFDTVLWAIGRVPETRNLNLEK 331

Query: 298 AGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + +  
Sbjct: 332 AGVNTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTL 391

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           M+Y  + T VFTP+EYGC GLSEE++   +G + +EVYH  + PLE+++A++    A  C
Sbjct: 392 MNYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRD---ASQC 448

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K+VC +     VLG H+LGPNAGEVTQ   L ++ G +Y Q++ TVGIHP
Sbjct: 449 YIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHP 500


>ref|NP_072106.1| thioredoxin reductase 2, mitochondrial precursor [Rattus
           norvegicus]
 sp|Q9Z0J5|TRXR2_RAT RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Thioredoxin reductase TR3; Flags: Precursor
 gb|AAD13801.1| thioredoxin reductase [Rattus norvegicus]
 gb|AAH85734.1| Thioredoxin reductase 2 [Rattus norvegicus]
          Length = 526

 Score =  439 bits (1129), Expect = e-121
 Identities = 235/472 (49%), Positives = 315/472 (66%), Gaps = 19/472 (4%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL+VIGGGSGGLAC+KEAA  G+KV V DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 41  NFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMH 100

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VK
Sbjct: 101 QAALLGGMI-RDAQHYGWEV----AQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVK 155

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGEL--AVSSDDIFW 180
           Y N+  SFV+ HT+          +++ +H+VIA GGRP+    + G L   ++SDDIFW
Sbjct: 156 YFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFW 215

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +K+  PGKTLVVGASYVALECAGFL G+G    VM+RS+ LRGFDQ MAS + E+ME   
Sbjct: 216 LKE-SPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHME-SH 273

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLDE 297
           G  F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L++
Sbjct: 274 GTRFLKGCVPSLIRKLPTNQLQVTW--EDLASGKEDVGTFDTVLWAIGRVPETRNLNLEK 331

Query: 298 AGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQ 355
           AGV  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + +  
Sbjct: 332 AGVNTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTL 391

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           M+Y  + T VFTP+EYGC GLSEE++   +G + +EVYH  + PLE+++A++    A  C
Sbjct: 392 MNYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRD---ASQC 448

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+K+VC +     VLG H+LGPNAGEVTQ   L ++ G +Y Q++ TVGIHP
Sbjct: 449 YIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHP 500


>ref|XP_001630291.1| predicted protein [Nematostella vectensis]
 gb|EDO38228.1| predicted protein [Nematostella vectensis]
          Length = 593

 Score =  438 bits (1127), Expect = e-121
 Identities = 237/474 (50%), Positives = 315/474 (66%), Gaps = 18/474 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SY+YDL+VIGGGSGGLAC+KEAA  G+KV VLD+VKP+P GT+WGLGGTCVNVGCIPKKL
Sbjct: 107 SYEYDLIVIGGGSGGLACAKEAAQLGRKVAVLDFVKPTPKGTTWGLGGTCVNVGCIPKKL 166

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+GE L  D   +GW       +    +W+ L   V            V+LR K 
Sbjct: 167 MHQAALLGEAL-KDARLYGWEF----DEKVKHNWESLREGVQNHIGSLNWGYRVQLREKS 221

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHV-VIAVGGRPRQLACLGG-ELAVSSDDI 178
           V Y+N  G F+D HT+K    K+GT+ I T    V+A+G RPR     G  E  ++SDD+
Sbjct: 222 VTYKNAFGEFIDNHTIKA-TDKRGTETIMTAETFVLAMGLRPRYPNIPGAKEYGITSDDL 280

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +    PG T+++GASYV+LECAGFL  MG  V V+VRSILLRGFDQ MA K G +ME 
Sbjct: 281 FSLPYC-PGTTVLIGASYVSLECAGFLAAMGLDVTVVVRSILLRGFDQQMAEKAGSFMET 339

Query: 239 QSGIEFIRKTVPQSITKLDS---GQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
             G++F R  VP  + +L+    G+L V +  E G+      +TV+ A GRD     +GL
Sbjct: 340 H-GVKFKRPAVPTKVEQLEEGSPGKLRVHYKLEGGEEGHLDCNTVVFAIGRDACTTGIGL 398

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVKLN K  ++   +NEQ++ PN+YAIGD++D   ELTPVAIQAGRLLSRRLY   T
Sbjct: 399 EKVGVKLNPKNQKVIAGDNEQSSVPNIYAIGDILDGKLELTPVAIQAGRLLSRRLYRNDT 458

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
              DY  + T VFTP+EYG  G SEED+ +++G ++VEVYH  F PLE+++A++++   +
Sbjct: 459 KLCDYINVATTVFTPLEYGAIGYSEEDAIQKFGQENVEVYHTLFQPLEYTVAQRSK---D 515

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY K++C+K  +  V+GFH LGPNAGE+TQ   +A K G T +   DT+GIHP
Sbjct: 516 DCYAKLICNKADSERVVGFHVLGPNAGEITQGYAVAFKCGATKEHFDDTIGIHP 569


>ref|NP_777051.1| thioredoxin reductase 2, mitochondrial precursor [Bos taurus]
 sp|Q9N2I8|TRXR2_BOVIN RecName: Full=Thioredoxin reductase 2, mitochondrial; AltName:
           Full=Thioredoxin reductase TR3; Flags: Precursor
 dbj|BAA82153.1| thioredoxin reductase [Bos taurus]
          Length = 511

 Score =  438 bits (1126), Expect = e-120
 Identities = 241/471 (51%), Positives = 309/471 (65%), Gaps = 20/471 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA  GKKV VLDYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 28  YDLLVIGGGSGGLACAKEAAQLGKKVAVLDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQ 87

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q P   W  L   V            ++L+ ++VKY
Sbjct: 88  AALLGGMI-RDAPHYGWGV----AQAP-HSWATLADAVQNHVKSLNWGHRIQLQDRKVKY 141

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            NV  SFVD HT  +    KG +E  ++  H+VIA GGRPR    + G  E  ++SDD+F
Sbjct: 142 FNVKASFVDTHT--VCGVSKGGEETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDLF 199

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAG L G+G    VM+RS+ LR FDQ MAS + E+M   
Sbjct: 200 WLKE-SPGKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPLRAFDQQMASLVTEHM-AG 257

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE-TFDTVLNATGRDPDVAKLGLDEA 298
            G   +R   P+ + KL   QL V W+    D  +  TFDTVL A GR P+ A L L++A
Sbjct: 258 HGTRILRGCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKA 317

Query: 299 GVKLNEKTGRIWVNNEQTTT-PNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV  N  TG+I V+ ++TT+ P++YAIGDV +  PELTP AI AGRLL++RL    +  M
Sbjct: 318 GVHTNPVTGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLM 377

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY  + T VFTP+EYGC GLSEE +   +G++ VEVYH  + PLE+++ ++    A  CY
Sbjct: 378 DYSSVPTTVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRD---ASQCY 434

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +K+VC +     VLG H+LGPNAGEV Q   L +K G +Y QL+ TVGIHP
Sbjct: 435 IKMVCLREPPQLVLGLHFLGPNAGEVIQGFALGIKCGASYQQLMRTVGIHP 485


>ref|XP_002948663.1| NADPH-dependent thioredoxin reductase 1 [Volvox carteri f.
           nagariensis]
 gb|EFJ50043.1| NADPH-dependent thioredoxin reductase 1 [Volvox carteri f.
           nagariensis]
          Length = 511

 Score =  437 bits (1125), Expect = e-120
 Identities = 243/475 (51%), Positives = 309/475 (65%), Gaps = 18/475 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL+VIGGGSGGLAC+KEAA  GKKVC+LDYV PSP GT+WGLGGTCVNVGCIPKKL 
Sbjct: 20  YDWDLIVIGGGSGGLACAKEAAKLGKKVCLLDYVVPSPQGTTWGLGGTCVNVGCIPKKLF 79

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+GE    D  S+GW +     +    DW+ LV  V            V LR   V
Sbjct: 80  HQAGLLGEGF-SDARSYGWKL----PEGVDLDWEALVMGVQSHIGSLNWGYRVALRDASV 134

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTK-EITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           KY N  G F+DPHT++    + GTK  +T   +VIAVGGRP+ L   G  EL ++SDDIF
Sbjct: 135 KYLNAKGHFIDPHTVEAVE-RNGTKTSLTAERIVIAVGGRPKFLGVPGDQELCLTSDDIF 193

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
             +  +PGKTLVVGASY+ALECAGFL  +G+ V VM RSI LRGFDQ++A  IG  +E +
Sbjct: 194 -SRTTKPGKTLVVGASYIALECAGFLHALGFPVAVMARSIFLRGFDQEIAEMIGRDLE-R 251

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITED-GDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            G+  +R  VP +  + D  Q+   +   D G    E+FDTVL A GRD   + LGLD A
Sbjct: 252 RGVRILRPAVPTAFER-DGEQVRCTFKNLDFGLEMSESFDTVLLAVGRDACTSDLGLDRA 310

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV ++ ++G+I V  EQT  P +YAIGDV++   ELTPVAI+AG  L+RRLY   T+QMD
Sbjct: 311 GVTVDPRSGKIPVVAEQTNVPWIYAIGDVLENRQELTPVAIKAGVRLARRLYGAATLQMD 370

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA----- 412
           YD + T VFTP+EYGC G SEE +  +YG+D+VEVY     PLEW++  +          
Sbjct: 371 YDAVPTTVFTPLEYGCVGYSEEAATAKYGEDNVEVYVSYLKPLEWTMNHEEHNGQPVRED 430

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            S Y K++ +K+ N  V+G HYLGPNAGE+ Q M +A+K G T     D +GIHP
Sbjct: 431 NSVYCKLITNKSDNERVVGVHYLGPNAGEIIQGMAVAIKAGATKADFDDCIGIHP 485


>ref|XP_001488273.1| PREDICTED: similar to TXNRD2 protein [Equus caballus]
          Length = 489

 Score =  437 bits (1125), Expect = e-120
 Identities = 243/473 (51%), Positives = 313/473 (66%), Gaps = 23/473 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA  GKKV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 7   YDLLVIGGGSGGLACAKEAAQLGKKVAVVDYVEPSPRGTRWGLGGTCVNVGCIPKKLMHQ 66

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V  +   VP  DW+++   V            V+L+ ++VKY
Sbjct: 67  AALLGGMI-RDAPHYGWEVPPL---VP-HDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKY 121

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFV+ H   +    K  KE  ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 122 FNIKASFVNEH--MVCGVTKDGKETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDIF 179

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VMVRSI LRGFDQ M+S + EYM   
Sbjct: 180 WLKE-SPGKTLVVGASYVALECAGFLTGLGLDATVMVRSIPLRGFDQQMSSLVTEYM-AS 237

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITED---GDCFEETFDTVLNATGRDPDVAKLGLD 296
            G  F+R   P  + +L  GQL V W  ED   G     TFDTVL A GR P+   L L+
Sbjct: 238 HGTRFLRGCTPSRVGRLPDGQLQVTW--EDLASGKKDVGTFDTVLWAIGRVPETRSLHLE 295

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
            AGV  +  + +I V+  E T+ P++YAIGDV +  PELTP A+ AG+LL+RRL  + + 
Sbjct: 296 NAGVNTHPNSQKILVDAGEATSVPHIYAIGDVAEGRPELTPPAVMAGKLLARRLCGQSSD 355

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDYD + T VFTP+EYGC GLSEE +   +G++ VEVYH  + PLE+++AE+    A  
Sbjct: 356 LMDYDNVPTTVFTPLEYGCVGLSEEKAVARHGEEHVEVYHAYYKPLEFTVAERD---ASQ 412

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ T+GIHP
Sbjct: 413 CYIKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTLGIHP 465


>gb|EFX87625.1| hypothetical protein DAPPUDRAFT_306444 [Daphnia pulex]
          Length = 611

 Score =  437 bits (1124), Expect = e-120
 Identities = 234/477 (49%), Positives = 307/477 (64%), Gaps = 21/477 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLA SKEAA  G KV V D+V P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 121 YDYDLVVIGGGSGGLAASKEAAMLGAKVAVCDFVVPTPIGTAWGLGGTCVNVGCIPKKLM 180

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++++G+ +  D   FGW +     +  T +WK +V  +            V LR K+V
Sbjct: 181 HQAAILGQSVS-DAKKFGWELP----ETATHNWKTMVEAIQAHIGSLNWGYRVALREKKV 235

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N    FVDPHTLK    KK    IT +++++A GGRPR     G  E  ++SDDIF 
Sbjct: 236 NYLNAFAEFVDPHTLKTTDKKKKETTITAKYILLATGGRPRYPDIPGAQEFGITSDDIFS 295

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +  + PGKTL+VGASY+ALECAGFL G+G    VMVRSILLRGFDQ MA+ IG YME + 
Sbjct: 296 LP-RHPGKTLLVGASYIALECAGFLAGLGIDATVMVRSILLRGFDQQMANLIGSYME-KH 353

Query: 241 GIEFIRKTVPQSITKLDS--------GQLLVKWITEDGDCFEETFDTVLNATGRDPDVAK 292
           GI F    VP  + +++          ++ V    E G+  EE ++TVL A GRD    K
Sbjct: 354 GIRFQHGYVPTKLERIEEACIEKGTPARIKVTSQNEQGELMEEEYNTVLFAIGRDACTNK 413

Query: 293 LGLDEAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYN 350
           +G+++A V LN K G++  +  EQT  P++YAIGD++D   ELTPVAIQAGRLL++RL+ 
Sbjct: 414 IGIEKANVMLNPKNGKVICDEKEQTNIPHIYAIGDILDGKLELTPVAIQAGRLLAQRLFG 473

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
            GT+  DY  + T VFTP+EYGCCGLSEED+ ++YG   +EVYH    PLE ++ ++   
Sbjct: 474 NGTLLTDYVNVPTTVFTPLEYGCCGLSEEDAIDKYGAKDIEVYHSYLTPLEVTVPKRD-- 531

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
                Y K++C K+ N  V+G H + PNAGE+TQ   + +KLG T     + +GIHP
Sbjct: 532 -DNEGYAKLICVKSLNEKVVGLHIVSPNAGEITQGFAIGLKLGATKADFDNLIGIHP 587


>gb|EFR25272.1| hypothetical protein AND_09546 [Anopheles darlingi]
          Length = 510

 Score =  435 bits (1119), Expect = e-120
 Identities = 241/475 (50%), Positives = 312/475 (65%), Gaps = 16/475 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGLAC+K+A   G KV VLD+VKPSP GT WGLGGTCVNVGCIPKKL
Sbjct: 18  NYDYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPQGTRWGLGGTCVNVGCIPKKL 77

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + HD   +GW     +      DW  L  +V            V+LR ++
Sbjct: 78  MHQASLLGEAI-HDSQPYGWQF--TDPASVRHDWATLTESVQNHIKSVNWVTRVDLRDQK 134

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N LG F D HT+         +E+ T+HVVIAVGGRPR     G  E  ++SDDIF
Sbjct: 135 VEYINGLGYFRDAHTVVARMKNDTERELRTKHVVIAVGGRPRYPDIPGAVEHCITSDDIF 194

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +  + PGKTL+VGA Y+ LECAGFLKG+GY V VMVRSILLRGFDQ MA+ IG+ M ++
Sbjct: 195 SL-PRAPGKTLLVGAGYIGLECAGFLKGLGYDVTVMVRSILLRGFDQQMATMIGDSM-VE 252

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITE--DGDCFEETFDTVLNATGRDPDVAKLGLDE 297
            GI F  KT P ++ K   G+LLV++ TE  +    E+TFDTVL A GR  +   L LD+
Sbjct: 253 KGIRFHHKTRPLAVEKQPDGRLLVRYETEGAESGTAEDTFDTVLFAIGRQAETGSLQLDK 312

Query: 298 AGVKLNE--KTGRIWVNNE--QTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           AGV   +  K+ ++ V++E  +T   NVYA+GDV+   PELTPVAI AGR+++RRL+   
Sbjct: 313 AGVVTADGGKSDKLDVDDESHRTNVENVYAVGDVLYRKPELTPVAIHAGRIIARRLFGGS 372

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
           +  MDY  + T VFTP+EYGC GLSEE ++  +G D++EVYH  + P E+ + ++   + 
Sbjct: 373 SETMDYRDVATTVFTPLEYGCVGLSEEAAEAAHGKDNIEVYHAYYKPTEFFVPQR---SV 429

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             CY+K V  +  +  VLG H+LGP AGEV Q    A+K G T   L +TVGIHP
Sbjct: 430 RYCYLKTVALREGDQRVLGLHFLGPAAGEVIQGFAAALKCGLTMKVLRNTVGIHP 484


>ref|XP_002115731.1| hypothetical protein TRIADDRAFT_50766 [Trichoplax adhaerens]
 gb|EDV21583.1| hypothetical protein TRIADDRAFT_50766 [Trichoplax adhaerens]
          Length = 522

 Score =  433 bits (1114), Expect = e-119
 Identities = 234/468 (50%), Positives = 315/468 (67%), Gaps = 20/468 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DLVVIGGGSGGLAC+KEA++ GKKV ++D+V+P+ HGT+WGLGGTCVNVGCIPKKLMHQ
Sbjct: 47  FDLVVIGGGSGGLACAKEASTLGKKVAIVDHVEPTVHGTTWGLGGTCVNVGCIPKKLMHQ 106

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G+ L  D   +GW + S + +     W+ L   V            V+L++K++ Y
Sbjct: 107 AALLGQSL-QDARHYGWQLPSSSYE---HSWETLRDGVRNYIKSLNWGYRVQLKNKKIDY 162

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIFWM 181
            N  G+F+  H +K+   K G       + VIAVGGRPR    + G  E A+SSDD+F +
Sbjct: 163 LNGKGTFLSRHEIKV-DLKSG------NNYVIAVGGRPRIPNNIPGAREYAISSDDLFSL 215

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
             K PGK L++GA Y+ALECAGFL G+G    +M RSI LR FDQDM S I E ME + G
Sbjct: 216 -DKAPGKVLIIGAGYIALECAGFLSGIGCDTSIMARSICLRSFDQDMVSLITENME-EEG 273

Query: 242 IEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           I FIRK+ P  ++K    ++ V++  TE G      +D V+ A GRDP  A L L+ A V
Sbjct: 274 ISFIRKSQPLRMSKTTGDKIEVEYENTETGLKSIGLYDNVMFAVGRDPTTASLNLNVANV 333

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
           K++ ++ +I   NEQTT PN+YAIGDV+   PELTPVAI AGRLL+RRL N  + QMDY 
Sbjct: 334 KIHPESKKILAENEQTTCPNIYAIGDVLHGKPELTPVAIHAGRLLARRLCNVSSTQMDYA 393

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKV 419
           +I T +FTP+EYGC G+SE  ++E Y  +++EVYH  ++PLE+++   T+   + CYVK 
Sbjct: 394 QIPTTIFTPLEYGCIGISEAKAEELYFKENIEVYHAFYLPLEYAI---TQRVCKQCYVKA 450

Query: 420 VCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           VC K+ N  ++G H+LGPNAGEV Q    AMK G TYDQ+V+T+GIHP
Sbjct: 451 VCLKSDNERIIGLHFLGPNAGEVIQGFATAMKCGVTYDQVVNTIGIHP 498


>gb|ACL81231.1| thioredoxin reductase 2 [Moneuplotes crassus]
          Length = 508

 Score =  431 bits (1108), Expect = e-118
 Identities = 230/471 (48%), Positives = 304/471 (64%), Gaps = 14/471 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHG---TSWGLGGTCVNVGCIPK 58
           YDYDL VIGGGSGGLAC+K A   G KV V D+VKPSPHG    +WG+GGTCVNVGCIPK
Sbjct: 21  YDYDLFVIGGGSGGLACAKAAQECGAKVAVADFVKPSPHGYGVVTWGVGGTCVNVGCIPK 80

Query: 59  KLMHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRS 118
           KL+H S+ +GE  + D AS GW+      + P  DW +++SN+             +LR 
Sbjct: 81  KLLHYSANLGEA-YVDRASSGWD-----HEKPKHDWGKMISNINNHIRAINFSIKTDLRK 134

Query: 119 KQVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDD 177
           + +K+   L SF DPHT++L + K  T+ +T  H+VIA GGRP      G  E  ++SDD
Sbjct: 135 RGIKFYEKLASFADPHTIQLLNKKGKTELVTANHIVIATGGRPLYPDIPGAKEYGITSDD 194

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           IFW+K K PGKTLV+GASY+ALECAGFL   G  V V VRS+ LRGFDQDMA+ + + ME
Sbjct: 195 IFWLK-KNPGKTLVIGASYIALECAGFLHSFGNDVSVCVRSVFLRGFDQDMANMLAKDME 253

Query: 238 MQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
              G++FI+ ++P  I K +    L+ ++T   +      DTVL A GR      L L+ 
Sbjct: 254 EHGGVKFIKNSIPTKIEKDEETGKLICYLTSREEEITIEVDTVLFAIGRYAVTKDLNLEN 313

Query: 298 AGVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTVQM 356
           AG+K+      I    +QT   N+YAIGDVI    ELTP AIQ G+LL+RRLY   T  M
Sbjct: 314 AGLKVESNGKFITDEFQQTNVENIYAIGDVIHGKLELTPTAIQTGKLLARRLYAGETTTM 373

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           D+  I T +FTP+EYGC G SEE++KE+YG D+++VYH  F PLEW+ A+       +CY
Sbjct: 374 DFCDIPTTIFTPLEYGCVGYSEEEAKEKYG-DAIKVYHTYFKPLEWNYAKSI-YKYRNCY 431

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           VKV+ + T N+ V+G+H L PNAGE+TQ + +A+K+G T  +L + VGIHP
Sbjct: 432 VKVIINTTENDRVIGYHLLAPNAGEITQGIAIAIKIGLTKHKLDNCVGIHP 482


>gb|ACL81230.1| thioredoxin reductase 1 [Moneuplotes crassus]
          Length = 498

 Score =  431 bits (1108), Expect = e-118
 Identities = 240/470 (51%), Positives = 304/470 (64%), Gaps = 14/470 (2%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL VIGGGSGGLAC+K A   G KV V D+VKP+P GT W +GGTCVNVGCIPKKL
Sbjct: 14  SYDYDLFVIGGGSGGLACAKVAQEAGAKVAVADFVKPTPKGTKWKVGGTCVNVGCIPKKL 73

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH S+L+G   +HD    GW       + P+ DW ++++NV             ++R + 
Sbjct: 74  MHYSALLGNS-YHDQVESGWE-----HEKPSHDWGKMITNVNNHIRGINFGYKADMRKRG 127

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           +K+     SFVDPHT++L   K  T+ IT+ + VIA GGRP      G  E A++SDDIF
Sbjct: 128 IKFHEKFASFVDPHTVQLVDKKGKTEMITSNYFVIATGGRPLYPDIPGAKEHAITSDDIF 187

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           WMK   PGKTLVVGASYVALECAGFL   G  V V VRSI LRGFDQDMA KI + ME+ 
Sbjct: 188 WMKDN-PGKTLVVGASYVALECAGFLHHFGNEVSVCVRSIFLRGFDQDMAQKIAKDMEL- 245

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAG 299
           SGI FIR +VP  I K +    L  ++T  G+      DTVL A GR    A L L  AG
Sbjct: 246 SGINFIRDSVPTKIEKDEETGKLTCFLTVGGEETTVEVDTVLFAIGRYAVTADLNLGNAG 305

Query: 300 VKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTVQMD 357
           + + EK G+   +  ++T   N+YAIGDV+    ELTP AIQAGRLL+ RL+  GT  MD
Sbjct: 306 L-IAEKNGKFITDKYQKTNVDNIYAIGDVLHGKLELTPTAIQAGRLLADRLFAGGTTTMD 364

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYV 417
           +  + T +FTP+EYGC G SEED++EEYG D ++VYH  F PLEW+ A+       +CYV
Sbjct: 365 FYDVPTTIFTPLEYGCVGYSEEDAREEYG-DFIKVYHTYFQPLEWNFAKSI-YKERNCYV 422

Query: 418 KVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           K++ +   N+ V+GFH L PNAGE+TQ + +A+K+G T  QL + VGIHP
Sbjct: 423 KIIVNTADNDRVIGFHILCPNAGEITQGIAIAIKVGVTKPQLDNCVGIHP 472


>ref|XP_001696072.1| NADPH-dependent thioredoxin reductase 1 [Chlamydomonas reinhardtii]
 gb|EDP01021.1| NADPH-dependent thioredoxin reductase 1 [Chlamydomonas reinhardtii]
          Length = 505

 Score =  431 bits (1108), Expect = e-118
 Identities = 242/476 (50%), Positives = 308/476 (64%), Gaps = 18/476 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDLVVIGGGSGGLAC+KEAA  GKKVC+LDYV PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 13  AYEYDLVVIGGGSGGLACAKEAAKLGKKVCLLDYVVPSPAGTSWGLGGTCVNVGCIPKKL 72

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH + L+GE    D   +GW +     +    +W+ LV  V            V LR   
Sbjct: 73  MHNAGLLGEGF-SDARGYGWKL----PEKIEMNWEDLVMGVQNHIGSLNWGYRVALREAS 127

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKE-ITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           VKY N  GSFVD HT++    + GTK  +T   VVIAVGGRP+ L   G  EL ++SDDI
Sbjct: 128 VKYLNAKGSFVDAHTVEAVE-RNGTKHTLTAERVVIAVGGRPKYLGVPGDKELCITSDDI 186

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F  +   PGKTLVVGASY+ALECAGFL+ +GY V VM RSI LRGFDQ++A  IG+ ME 
Sbjct: 187 F-SRATPPGKTLVVGASYIALECAGFLRALGYEVAVMARSIFLRGFDQEIAELIGKDME- 244

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITED-GDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + G+  I+  VP +  + D  Q+   +   D G    E+FDTVL A GRD     LGL++
Sbjct: 245 RRGVRMIKPAVPTAFER-DGEQIKCTFKNLDFGVEMSESFDTVLLAVGRDACTFDLGLEK 303

Query: 298 AGVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
            GV  ++ +G+I V  EQT  P++YAIGDV+++  ELTPVAI+AG  L+RRLY   T+QM
Sbjct: 304 VGVTYDKSSGKIPVTAEQTNVPSIYAIGDVLESRQELTPVAIKAGIRLARRLYAGATLQM 363

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR-----IA 411
           DYD + T VFTP+EYGC G SEE +  +YG D++EVY     PLEW++  +        A
Sbjct: 364 DYDAVPTTVFTPLEYGCVGYSEEAATVKYGADNIEVYVSYLKPLEWTMNHEEHNGEPVRA 423

Query: 412 AESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             S +VK++ +   N  V+G HYLGPNAGE+ Q + +A+K   T     D +GIHP
Sbjct: 424 DNSVFVKLITNTADNERVVGAHYLGPNAGEIIQGVAVAVKANATKADFDDCIGIHP 479


>ref|XP_514983.2| PREDICTED: thioredoxin reductase 2 isoform 4 [Pan troglodytes]
          Length = 450

 Score =  431 bits (1108), Expect = e-118
 Identities = 235/458 (51%), Positives = 306/458 (66%), Gaps = 23/458 (5%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 7   DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 66

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 67  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 121

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 122 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 179

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 180 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 237

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 238 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDCTTGKEDTGTFDTVLWAIGRVPDTRSLNL 295

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YA+GDV++  PELTP AI AGRLL +RL+   +
Sbjct: 296 EKAGVDTSPDTQKILVDSREATSVPHIYAVGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 355

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 356 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVAHHGQEHVEVYHAHYKPLEFTVAGRD---AS 412

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMK 451
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K
Sbjct: 413 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIK 450


>ref|XP_001166615.1| PREDICTED: similar to mitochondrial thioredoxin reductase isoform 3
           [Pan troglodytes]
          Length = 481

 Score =  431 bits (1108), Expect = e-118
 Identities = 235/458 (51%), Positives = 306/458 (66%), Gaps = 23/458 (5%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KEAA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 38  DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMH 97

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 98  QAALLGGLI-QDAPNYGWEV----AQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 152

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT  +    KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 153 YFNIKASFVDEHT--VCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 210

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 211 FWLKE-SPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHM-A 268

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 269 SHGTRFLRGCAPSRVRRLPDGQLQVTW--EDCTTGKEDTGTFDTVLWAIGRVPDTRSLNL 326

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YA+GDV++  PELTP AI AGRLL +RL+   +
Sbjct: 327 EKAGVDTSPDTQKILVDSREATSVPHIYAVGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 386

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 387 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVAHHGQEHVEVYHAHYKPLEFTVAGRD---AS 443

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMK 451
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K
Sbjct: 444 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIK 481


>gb|EEZ99907.1| hypothetical protein TcasGA2_TC002698 [Tribolium castaneum]
          Length = 450

 Score =  430 bits (1106), Expect = e-118
 Identities = 229/451 (50%), Positives = 299/451 (66%), Gaps = 11/451 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           +YDLVVIGGGSGGLA +KEAA  G KV VLDYV PSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   EYDLVVIGGGSGGLAAAKEAAGLGAKVAVLDYVTPSPKGTKWGLGGTCVNVGCIPKKLMH 68

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+GE +  D  S+GW            DW  L   V            VELR K+V+
Sbjct: 69  QAALLGEAI-EDAKSYGWQFPQPEN--IKHDWASLRQAVQNHIKSVNWVTRVELRDKKVE 125

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWM 181
           Y N LG F DPHT+     K+G + +T+++ +IAVGGRPR     G  E  ++SDDIF +
Sbjct: 126 YINGLGVFKDPHTVHT-VTKQGERTLTSKYFLIAVGGRPRYPNIPGAVEYGITSDDIFSL 184

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
            ++ PGKTLVVGA Y+ LECAGFL+G+GY   VMVRS++LRGFDQ MA  I   ME + G
Sbjct: 185 -EEAPGKTLVVGAGYIGLECAGFLRGLGYDATVMVRSVVLRGFDQQMAKLIASAME-EKG 242

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVK 301
           ++F+ K +P+S+ K    +LLVKW  E G  FE+ FDTVL A GR     +L LD+AGVK
Sbjct: 243 VKFLHKCLPKSVEKRSDNKLLVKWSNETGQEFEDVFDTVLFAIGRRALTRELHLDKAGVK 302

Query: 302 LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
           +     +I   NEQ+  P+++A+GDV+   PELTPVAI AGRLL+RRL+   TVQMDYD 
Sbjct: 303 VAGDGEKIDAMNEQSNVPHIFAVGDVLYKKPELTPVAIHAGRLLARRLFGNSTVQMDYDN 362

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           + T VF+P+EYG  G+SEE + + +G++++E+YH  + P E+ + ++   +   CY+KVV
Sbjct: 363 VATTVFSPLEYGSVGISEETAIQRFGENNIEIYHAYYKPTEFFIPQR---SIAHCYLKVV 419

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMK 451
             +     VLG H++GP AGEV Q    AMK
Sbjct: 420 AKREGPQQVLGMHFIGPQAGEVIQGFAAAMK 450


>ref|XP_001014761.2| thioredoxin and glutathione reductase family protein [Tetrahymena
           thermophila]
 gb|EAR94708.2| thioredoxin and glutathione reductase family protein [Tetrahymena
           thermophila SB210]
          Length = 489

 Score =  430 bits (1105), Expect = e-118
 Identities = 240/472 (50%), Positives = 307/472 (65%), Gaps = 16/472 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YD  VIGGGSGGLA +KEAASFG +V V D+VKPSP GT WGLGGTCVNVGCIPKKLM
Sbjct: 5   FKYDFFVIGGGSGGLAAAKEAASFGARVAVADFVKPSPVGTKWGLGGTCVNVGCIPKKLM 64

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           H ++  GE  H    + GW       +    +W+ +V  V            VEL  K+V
Sbjct: 65  HFAASYGES-HEAQKNMGWTEIKEKNK---HEWQPMVERVQAHIKKLNWGYKVELAEKEV 120

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGE-LAVSSDDIFW 180
           KY N L S V  +T++L + K   +++T ++++IAVGGRP  L     E L ++SDDIF 
Sbjct: 121 KYYNSLASIVGKNTIELTNRKGEKEQVTAKYILIAVGGRPTFLDIPNTEKLVITSDDIFS 180

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           M Q  PGKTLVVGASY+ALECAGFL G GY V VMVRSILLRGFDQ++A KIGEYM  + 
Sbjct: 181 M-QNPPGKTLVVGASYIALECAGFLAGFGYDVTVMVRSILLRGFDQEIAEKIGEYM-ARH 238

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKW---ITEDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           G +FIR TVP  I     G+  V W   +   GD  EE FDTV+ A GR  D   +G++ 
Sbjct: 239 GTKFIRGTVPHHIEATPDGRRRVVWKSPVEGQGD-VEEIFDTVMLAIGRTSDTKNIGVET 297

Query: 298 AGVKLNEKTGRIWVNNEQTT-TPNVYAIGDVID-APELTPVAIQAGRLLSRRLYNEGTVQ 355
            G+K  +  G+I  N++ TT   N++AIGD +D  PELTP AI+AGRLL+RRL+N  T  
Sbjct: 298 MGIK-TKPNGKIIANDDDTTNVENIFAIGDCVDKRPELTPTAIKAGRLLARRLFNGDTKL 356

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           MDY+ I T VFTPIEYG  GLSEED+K +YG+D+++VY+  F PL+WS ++      +  
Sbjct: 357 MDYNSIPTTVFTPIEYGTIGLSEEDAKTKYGEDNIKVYYSIFTPLDWSYSDHKH--DDKG 414

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           + K++ +K  +  V+GFHYLGP+AGEVTQ   +A K   T     D VGIHP
Sbjct: 415 HAKLIVNKADDERVVGFHYLGPHAGEVTQGFAIAFKFKATKANFDDVVGIHP 466


>ref|XP_310514.3| thioredoxin reductase (AGAP000565-PB) [Anopheles gambiae str. PEST]
 emb|CAD70158.1| thioredoxin-disulfide reductase [Anopheles gambiae]
 gb|EAA06298.3| thioredoxin reductase (AGAP000565-PB) [Anopheles gambiae str. PEST]
          Length = 505

 Score =  426 bits (1094), Expect = e-117
 Identities = 234/477 (49%), Positives = 308/477 (64%), Gaps = 18/477 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDLVVIGGGSGGLAC+K+A   G KV VLD+VKPSP GT WGLGGTCVNVGCIPKKL
Sbjct: 11  NYEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKL 70

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + HD   +GW +   +      DW  L  +V            V+LR ++
Sbjct: 71  MHQASLLGEAI-HDSQPYGWQL--PDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQK 127

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDIF 179
           V+Y N LG F D HT+      +  +E+  +HVVIAVGGRPR     G  E  ++SDDIF
Sbjct: 128 VEYVNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIF 187

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            + Q  PG+TL+VGA Y+ LECAGFLKG+GY V VMVRSILLRGFDQ MA+ +G+ M ++
Sbjct: 188 SLPQ-APGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSM-VE 245

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITED----GDCFEETFDTVLNATGRDPDVAKLGL 295
            GI F  ++ P ++ K   G+LLV++ T D        E+ FDTVL A GR  +   L L
Sbjct: 246 KGIRFHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKL 305

Query: 296 DEAGVKLNE--KTGRIWVN--NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYN 350
             AGV   E  K+ ++ V+  + +T  P++YA+GDV+   PELTPVAI AGR+++RRL+ 
Sbjct: 306 ANAGVVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFG 365

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
               +MDY  + T VFTP+EYGC GLSEE ++  +G D +EVYH  + P E+ + ++   
Sbjct: 366 GSEERMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFVPQR--- 422

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +   CY+K V  +  N  VLG H+LGP AGEV Q    A+K G T   L +TVGIHP
Sbjct: 423 SVRYCYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHP 479


>emb|CAD30858.1| thioredoxin reductase [Anopheles gambiae]
          Length = 502

 Score =  426 bits (1094), Expect = e-117
 Identities = 234/477 (49%), Positives = 308/477 (64%), Gaps = 18/477 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDLVVIGGGSGGLAC+K+A   G KV VLD+VKPSP GT WGLGGTCVNVGCIPKKL
Sbjct: 8   NYEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKL 67

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + HD   +GW +   +      DW  L  +V            V+LR ++
Sbjct: 68  MHQASLLGEAI-HDSQPYGWQL--PDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQK 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDIF 179
           V+Y N LG F D HT+      +  +E+  +HVVIAVGGRPR     G  E  ++SDDIF
Sbjct: 125 VEYVNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            + Q  PG+TL+VGA Y+ LECAGFLKG+GY V VMVRSILLRGFDQ MA+ +G+ M ++
Sbjct: 185 SLPQ-APGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSM-VE 242

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITED----GDCFEETFDTVLNATGRDPDVAKLGL 295
            GI F  ++ P ++ K   G+LLV++ T D        E+ FDTVL A GR  +   L L
Sbjct: 243 KGIRFHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKL 302

Query: 296 DEAGVKLNE--KTGRIWVN--NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYN 350
             AGV   E  K+ ++ V+  + +T  P++YA+GDV+   PELTPVAI AGR+++RRL+ 
Sbjct: 303 ANAGVVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFG 362

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
               +MDY  + T VFTP+EYGC GLSEE ++  +G D +EVYH  + P E+ + ++   
Sbjct: 363 GSEERMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFVPQR--- 419

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +   CY+K V  +  N  VLG H+LGP AGEV Q    A+K G T   L +TVGIHP
Sbjct: 420 SVRYCYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHP 476


>ref|XP_001237264.1| AGAP000565-PA [Anopheles gambiae str. PEST]
 emb|CAD70159.1| thioredoxin-disulfide reductase [Anopheles gambiae]
 gb|EAU77244.1| AGAP000565-PA [Anopheles gambiae str. PEST]
          Length = 529

 Score =  426 bits (1094), Expect = e-117
 Identities = 234/477 (49%), Positives = 308/477 (64%), Gaps = 18/477 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDLVVIGGGSGGLAC+K+A   G KV VLD+VKPSP GT WGLGGTCVNVGCIPKKL
Sbjct: 35  NYEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKL 94

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+SL+GE + HD   +GW +   +      DW  L  +V            V+LR ++
Sbjct: 95  MHQASLLGEAI-HDSQPYGWQL--PDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQK 151

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDIF 179
           V+Y N LG F D HT+      +  +E+  +HVVIAVGGRPR     G  E  ++SDDIF
Sbjct: 152 VEYVNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIF 211

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            + Q  PG+TL+VGA Y+ LECAGFLKG+GY V VMVRSILLRGFDQ MA+ +G+ M ++
Sbjct: 212 SLPQ-APGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSM-VE 269

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITED----GDCFEETFDTVLNATGRDPDVAKLGL 295
            GI F  ++ P ++ K   G+LLV++ T D        E+ FDTVL A GR  +   L L
Sbjct: 270 KGIRFHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKL 329

Query: 296 DEAGVKLNE--KTGRIWVN--NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYN 350
             AGV   E  K+ ++ V+  + +T  P++YA+GDV+   PELTPVAI AGR+++RRL+ 
Sbjct: 330 ANAGVVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFG 389

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
               +MDY  + T VFTP+EYGC GLSEE ++  +G D +EVYH  + P E+ + ++   
Sbjct: 390 GSEERMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFVPQR--- 446

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +   CY+K V  +  N  VLG H+LGP AGEV Q    A+K G T   L +TVGIHP
Sbjct: 447 SVRYCYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHP 503


>emb|CAM96615.1| thioredoxin-glutathione reductase [Fasciola hepatica]
          Length = 598

 Score =  425 bits (1093), Expect = e-117
 Identities = 229/477 (48%), Positives = 303/477 (63%), Gaps = 20/477 (4%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDLVVIGGGSGGLA SKEAA FG K  V D+V P+P  T+ GLGGTCVNVGCIPKKL
Sbjct: 106 TYDYDLVVIGGGSGGLAASKEAARFGAKTAVFDFVVPTPQDTTRGLGGTCVNVGCIPKKL 165

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+ E +  D   FGW     + +    DW Q+V N+             +LRS  
Sbjct: 166 MHQAALLREGMP-DSVHFGWKW---DPEKIEHDWAQIVENIGNHIHSLNWGYRTQLRSIN 221

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V+Y N     VDPHT+K     K T  +T + +++A G RPR     G  E A++SDD+F
Sbjct: 222 VEYVNAFAEVVDPHTIKYTKKNKETGTVTAKVIILATGERPRYPGIPGDKEYAITSDDLF 281

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+    PGKTLVVGASYVALECAGFL   G+   VMVRSI LRGFDQ MA  IGEYM+ +
Sbjct: 282 WLPYP-PGKTLVVGASYVALECAGFLTRFGFDTTVMVRSIFLRGFDQQMADMIGEYMK-E 339

Query: 240 SGIEFIRKTVPQSITKLDS--------GQLLVKWITEDGDCFEETFDTVLNATGRDPDVA 291
            G +F+R  VP +I ++++        G   VK   E+G+ F   F+T++ A GRDP   
Sbjct: 340 HGTKFVRSCVPTAIEEIEARDKENQKPGLYRVKGKYENGEEFVGEFNTIVMAIGRDPTWD 399

Query: 292 KLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYN 350
           +  ++  G+KL++    I  +NEQ++  ++YAIGD++   P+LTPVAI AGR L+RRLY 
Sbjct: 400 RKAMESVGLKLDKAKRVICADNEQSSVDSIYAIGDIVSGKPQLTPVAIHAGRYLARRLYA 459

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
                 DY  + T +FTPIEYG CGLSEED+  +YG +++EVYH +F+PLEW++  +   
Sbjct: 460 GDIELTDYVNVPTTIFTPIEYGACGLSEEDAITKYGKENIEVYHSHFIPLEWTVPHR--- 516

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             E  Y K++C K+ +  V+G H LGPNAGE+TQ   +AMK G T      T+GIHP
Sbjct: 517 -PEDGYAKIICLKSDSERVIGLHVLGPNAGEMTQGFSVAMKAGATKADFDRTIGIHP 572


>ref|XP_001942650.1| PREDICTED: similar to thioredoxin reductase [Acyrthosiphon pisum]
          Length = 493

 Score =  425 bits (1092), Expect = e-117
 Identities = 227/468 (48%), Positives = 303/468 (64%), Gaps = 12/468 (2%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL+VIGGGSGGLAC+KEA+SFGK+V VLD+V PS  GT+WG+GGTCVNVGCIPKKLM
Sbjct: 10  YDFDLLVIGGGSGGLACAKEASSFGKQVVVLDFVIPSEKGTTWGIGGTCVNVGCIPKKLM 69

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE +  +  S+GWN+        +F+W+ LV  V            V+LR K++
Sbjct: 70  HQASLLGESI-QEARSYGWNI----PDPISFNWESLVEAVQNHIKSVNWVTRVQLRDKKI 124

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDIFW 180
           +Y N  G F D HT+         + IT + +VIAVGGRPR     G  E  ++SDD+F 
Sbjct: 125 EYVNGHGVFEDAHTVIAKMKNGKERRITAKDIVIAVGGRPRYPDFPGCKEYCITSDDLFS 184

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           M    PG TLV+GA Y+ LECAGFLKG+GY   VMVRS+LLRGFD+ M   +   ME   
Sbjct: 185 M-PTSPGNTLVIGAGYIGLECAGFLKGLGYEATVMVRSMLLRGFDRGMVDLVQAEME-HK 242

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           G+ F+   +P  ++K  +G+LLV+W   D       FDTVL ATGR     +L    AG+
Sbjct: 243 GVNFLFGKIPVKVSKQPNGKLLVEWKGGDEVSSAWEFDTVLVATGRKALSEELNPSAAGL 302

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
           +++ ++ +   N EQT  PN+YA+GDV+ + PELTPVAIQAG+LL+ RLYN    QMDYD
Sbjct: 303 QVHPESFKFITNAEQTNIPNIYAVGDVLHERPELTPVAIQAGKLLAGRLYNGIQEQMDYD 362

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKV 419
            + T VF+P+EYGC GL+EE++   Y ++ +EVYH  + P E+ + ++     + CY+KV
Sbjct: 363 NVATTVFSPLEYGCVGLTEEEAINRYTENGIEVYHAYYKPTEFFIPQKN---VKHCYLKV 419

Query: 420 VCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +        VLG H++GP AGEV Q    A+K G TY  L DTVGIHP
Sbjct: 420 ITLLEAPQKVLGMHFIGPQAGEVIQGYAAAIKAGLTYQHLKDTVGIHP 467


>ref|XP_002009206.1| GI11388 [Drosophila mojavensis]
 gb|EDW19682.1| GI11388 [Drosophila mojavensis]
          Length = 515

 Score =  424 bits (1091), Expect = e-116
 Identities = 233/473 (49%), Positives = 312/473 (65%), Gaps = 21/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLAC+KEA  +G +V  LDYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 31  FDYDLVVLGGGSGGLACAKEAVEYGARVLCLDYVKPTPAGTKWGVGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE +H +  ++GWNV   N +    DWK+LV  V            V+LR K+V
Sbjct: 91  HQASLLGEAVH-EAVAYGWNV---NDRDIKPDWKKLVKVVQNHIKSVNWVTRVDLRDKKV 146

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           +Y N +GSFV+PHT+K    +   K++T ++VVIAVGGRPR     G  EL ++SDDIF 
Sbjct: 147 EYVNSIGSFVNPHTIKYKTKQGELKQLTAQYVVIAVGGRPRYPPIKGAIELGITSDDIF- 205

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
             +KEPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M  + 
Sbjct: 206 SYEKEPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSEFLAAMM-TER 264

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKW----ITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           GI F+  T+P  + +   G+LLV++       DG    + FDTVL A GR   +  L L 
Sbjct: 265 GIHFLNTTIPMGVERTPEGKLLVQYRNTTTQTDG---SDVFDTVLWAIGRKGLIEDLNLG 321

Query: 297 EAGVK-LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTV 354
            AGV+  N+K   I  + E T+ P+++A+GD+I   PELTPVAI +GRLL+RRL+   T 
Sbjct: 322 AAGVQTYNDKV--IVDHTEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQ 379

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EY C G+SEE + E  G D++EV+H  + P E+ + ++   +   
Sbjct: 380 LMDYTDVATTVFTPLEYSCVGMSEEMAIERLGADNIEVFHGYYKPTEFFIPQK---SFRH 436

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K V + + +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 437 CYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 489


>gb|EGB07743.1| selenoprotein [Aureococcus anophagefferens]
          Length = 498

 Score =  424 bits (1090), Expect = e-116
 Identities = 228/471 (48%), Positives = 296/471 (62%), Gaps = 15/471 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYD+VV+GGGSGGLACSKE A  G KV VLD+VKPSP G++WGLGGTCVNVGCIPKKLM
Sbjct: 12  FDYDVVVVGGGSGGLACSKECAKLGAKVAVLDFVKPSPAGSTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           H +S+IGE L  D A+FGW   +        DW+ + S V            V LR   +
Sbjct: 72  HTASIIGETLKDDAAAFGWKDAAAGAH----DWESMKSTVQDHIKSLNFKYRVALREAGI 127

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGELAVSSDDIFWM 181
            Y N LG F D +T+ L   K     +T    ++AVGGRP +L C GGE A+ SDD+F +
Sbjct: 128 TYLNRLGEFEDKNTISLTDKKGNKTSVTAARFIVAVGGRPNKLGCPGGEHAIDSDDLFSL 187

Query: 182 KQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSG 241
             K PG+ L VG  Y+ALEC GF  GMGY    MVRSILLRGFD++   KI  +++   G
Sbjct: 188 -PKAPGRVLCVGGGYIALECGGFTAGMGYPTTCMVRSILLRGFDRECVGKIEAHIK-HHG 245

Query: 242 IEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDE---A 298
           ++      P  I K  +  +L   +T+ G    E +DTVL ATGR  D A LG+D    A
Sbjct: 246 VQLQVGVTPAKIEKDAATGVLT--VTDSGGGVHE-YDTVLVATGRYADTAALGIDNVPGA 302

Query: 299 GVKLNEKTGRIWVNNEQTT-TPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
              +N KT ++   +EQ    P+VYAIGDV++  PELTPVAI+AG  L+RRL+   T  M
Sbjct: 303 SANVNAKTKKLECVDEQLPGAPHVYAIGDVVEGRPELTPVAIEAGLRLARRLFGGKTEPM 362

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY+ + T +FTP+EYG  GLSE+D+K + G+ +VE Y   F PLE++L+E      + C+
Sbjct: 363 DYECVATTIFTPLEYGTIGLSEDDAKAQLGECNVESYISEFAPLEYALSETRSERGDGCF 422

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            K+V DK+    V+GFHYLGPNAGE+TQ   +AM+ G TY   + TVGIHP
Sbjct: 423 AKLVVDKSTGK-VVGFHYLGPNAGEITQGFSIAMRKGATYADFISTVGIHP 472


>ref|XP_002674924.1| thioredoxin reductase [Naegleria gruberi]
 gb|EFC42180.1| thioredoxin reductase [Naegleria gruberi]
          Length = 500

 Score =  423 bits (1088), Expect = e-116
 Identities = 240/477 (50%), Positives = 310/477 (64%), Gaps = 23/477 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDL+VIGGGSGG+A +KEA + G KV V DY+KPSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 17  YDYDLIVIGGGSGGIALAKEANALGAKVAVFDYIKPSPQGTTWGLGGTCVNVGCIPKKLM 76

Query: 62  HQSSLIGEILHHDCASFGW--NVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           H ++LIG+    D  +FGW  +VG    + P   W +LV  V             +LR K
Sbjct: 77  HTAALIGD-RSQDGTAFGWTNSVGHGTERKPHHQWGKLVEMVQDHIHGLNFKYRTDLRKK 135

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKE---ITTRHVVIAVGGRPRQLACLGG-ELAVSS 175
            + Y N+  SF+D HT++    K G +E    T R   IAVGGRP      G  E  +SS
Sbjct: 136 GITYHNLYASFIDAHTVE--GKKDGQEEGKRFTARRFAIAVGGRPLYPDIPGAKEYCISS 193

Query: 176 DDIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEY 235
           DDIF M +KEPGK+LVVGASYVALEC GFL G+G    +MVRS+ LRGFD++ A KI   
Sbjct: 194 DDIFSM-EKEPGKSLVVGASYVALECGGFLHGIGNDTTIMVRSVPLRGFDRECADKIVNV 252

Query: 236 MEMQSGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLG 294
           M    G++F +  VP S+ KL+SG+L V++   E  +   E FDTVL ATGR      L 
Sbjct: 253 MS-DEGVKFYQPCVPLSVNKLESGKLSVEYENVETKEKKTEEFDTVLFATGRYALTQALN 311

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L+  GVK  +K G+I+VN  EQ++ P++YAIGDVI    ELTPVAI+AG+LL+ RLYN  
Sbjct: 312 LENIGVK-TDKVGKIFVNKYEQSSVPHIYAIGDVIVGGLELTPVAIKAGKLLAARLYNSS 370

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
              MDYDK+ T VFTP+EYG CGL+EE++ + YG +++ +Y K++  LE+         A
Sbjct: 371 KKMMDYDKVPTTVFTPVEYGSCGLTEEEAVKRYGAENLTIYKKSYYVLEY------EPPA 424

Query: 413 ESC--YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             C  +VK++C++  N  VLGFHY+GPNAGEVTQ   +AM+   T +   DTVGIHP
Sbjct: 425 RECQAFVKLICNELDNERVLGFHYVGPNAGEVTQGFAVAMRCNATKEDFDDTVGIHP 481


>ref|NP_001177260.1| thioredoxin reductase 3 [Ciona intestinalis]
          Length = 623

 Score =  423 bits (1087), Expect = e-116
 Identities = 231/473 (48%), Positives = 307/473 (64%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDL+VIGGGSGGLA SK A+  GKKV V D+V+P+P G SWGLGGTCVNVGCIPKKLM
Sbjct: 135 YEYDLIVIGGGSGGLAASKRASELGKKVAVCDFVQPTPKGVSWGLGGTCVNVGCIPKKLM 194

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+S++G+ +  D  SFGW + S   +     W+ +V  V            V+LR K+V
Sbjct: 195 HQASMLGKSI-EDAKSFGWQLTS---EPVKNKWEGMVEAVQNYIGSLNWGYRVQLREKKV 250

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N    F D HT+   + +    ++T    ++AVG RPR     G  E  ++SDD+F 
Sbjct: 251 NYVNAYAKFEDQHTITTVNRRGKETKMTADKFIVAVGERPRYPDIPGAKEHCITSDDLFS 310

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLV+GASYVALECAGFLKG+G  V VMVRSI LRGFDQ MA K   YME + 
Sbjct: 311 LPYC-PGKTLVIGASYVALECAGFLKGIGLDVTVMVRSIFLRGFDQQMADKAAGYME-KE 368

Query: 241 GIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           G++F+R+ VP  I ++++G+     +   +TE+G+     ++TV+ A GRD     +GLD
Sbjct: 369 GVQFLRRCVPVKIEQVEAGEPGLLRVTGKMTENGEEVTGDYNTVILAIGRDSVTKTIGLD 428

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +  V+++ K G++ VN+ +QT   N++ IGD  +  PELTPVAI AGRLLS RLY   T+
Sbjct: 429 KINVQVS-KNGKVPVNDYDQTNVENIFCIGDNGEGKPELTPVAIHAGRLLSERLYGGSTL 487

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
           + DY+ + T VFTP+EY CCGLSEE +  +YG+D++EVYH N  PLEWS+         +
Sbjct: 488 KCDYEGVPTTVFTPLEYSCCGLSEEAAIAKYGEDNLEVYHTNVWPLEWSVPGHDN---NT 544

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CYVK + +K  +  V+G HYLGPNAGEV Q    AMK G T  QL  T+GIHP
Sbjct: 545 CYVKAITNKLDSERVIGLHYLGPNAGEVMQGFAAAMKCGITKAQLDQTIGIHP 597


>ref|XP_002047939.1| GJ11643 [Drosophila virilis]
 gb|EDW70281.1| GJ11643 [Drosophila virilis]
          Length = 517

 Score =  422 bits (1086), Expect = e-116
 Identities = 229/473 (48%), Positives = 311/473 (65%), Gaps = 21/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGSGGLAC+KEA  +G  V   D+VKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 33  YDYDLVVLGGGSGGLACAKEAVEYGAHVLCFDFVKPTPAGTKWGVGGTCVNVGCIPKKLM 92

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE +H +  ++GWNV   N +    DWK+LV +V            V+LR K+V
Sbjct: 93  HQASLLGEAVH-EAVAYGWNVNDQNIKP---DWKKLVKSVQDHIKSVNWVTRVDLRDKKV 148

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           +Y N +G FVDPHT++    +   K++T ++VV+AVGGRPR  +  G  E  ++SDDIF 
Sbjct: 149 EYVNSIGRFVDPHTIEYIQKQGERKQLTAKYVVVAVGGRPRYPSIPGATEFGITSDDIF- 207

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
             +KEPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M ++ 
Sbjct: 208 SYEKEPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSEFLAAMM-LER 266

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKW----ITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           GI F+  T+P ++ +   G+LLVK+       DG    + FDTVL A GR      L L 
Sbjct: 267 GIRFLNTTIPLAVERRADGKLLVKYQNTTTKTDG---SDVFDTVLWAIGRKGLTEDLNLG 323

Query: 297 EAGVK-LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTV 354
            AGV+  N+K   I  + E T  P+++A+GD+I   PELTPVAI +GRLL+RRL+   T 
Sbjct: 324 AAGVQTYNDKI--IVDHTEATNVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQ 381

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EY C G+SEE + E+ G +++EV+H  + P E+ + ++   +   
Sbjct: 382 LMDYTDVATTVFTPLEYSCVGMSEEMAIEKMGAENIEVFHAYYKPTEFFIPQK---SVRH 438

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K V + + +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 439 CYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 491


>emb|CBJ26963.1| Electron donor (NADH / NADPH)-dependent reductase [Ectocarpus
           siliculosus]
          Length = 520

 Score =  422 bits (1085), Expect = e-116
 Identities = 239/490 (48%), Positives = 306/490 (62%), Gaps = 33/490 (6%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYDYDL VIGGGSGG+A +K+AAS+GKKV + D+VKPSP GT WGLGGTCVNVGC+PKKL
Sbjct: 10  SYDYDLAVIGGGSGGMAVAKKAASYGKKVVLFDFVKPSPQGTKWGLGGTCVNVGCVPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH + L+G  + HD  +FGW VG+     P  DW+ +V  V            V L+S Q
Sbjct: 70  MHYAGLLGAGM-HDAKAFGWKVGN-----PEHDWEAMVETVQNHVKMLNFRYRVGLKSAQ 123

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V Y N L     PH +      K TK  T   V+IAVGGRP     + G  E A++SDD+
Sbjct: 124 VTYVNGLARLTGPHEVTCEKRGKETKH-TAARVIIAVGGRPVIPDDVPGAREHALTSDDL 182

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F ++   PGKTLVVGASY+ALECAGF++ +G  V V VRSILLRGFDQ +A K+G+ M+ 
Sbjct: 183 FSLR-TSPGKTLVVGASYIALECAGFMRELGLDVTVAVRSILLRGFDQQVAEKLGDVMK- 240

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDG--DCFEETFDTVLNATGRDPDVAKLGLD 296
             G++F+R  VP  I K   G+L V  +      +  + T+D+V  ATGR  D + +GL+
Sbjct: 241 DLGVKFVRPAVPSKIEKTSDGKLEVTLVDSKSGEEVSKGTYDSVFYATGRKADTSGIGLE 300

Query: 297 EAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-----------PELTPVAIQAGRLLS 345
            AGVK+N   G+I V NEQT   +++AIGD               PELTPVA+QAG LL+
Sbjct: 301 TAGVKVN-PNGKIPVENEQTNVEHIFAIGDCTSVDVMFHESHWANPELTPVAVQAGELLA 359

Query: 346 RRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLA 405
            RLY   T QMDY  + TAVFTP+EYGCCGLSEED+   YG+D VE Y   F  LE S A
Sbjct: 360 SRLYARATEQMDYSLVATAVFTPVEYGCCGLSEEDAIRLYGEDDVETYLFGFGTLEQSAA 419

Query: 406 EQTR-IAAE-------SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYD 457
            + + +  E       +   K+VC K++   V+GFH++GPNAGE+TQ  GLA++LG    
Sbjct: 420 HRVKHVEGEEEDDMPATNLSKLVCLKSQGEKVIGFHFVGPNAGEITQGFGLAVRLGAKKS 479

Query: 458 QLVDTVGIHP 467
                VGIHP
Sbjct: 480 DFNKLVGIHP 489


>dbj|BAH11490.1| unnamed protein product [Homo sapiens]
          Length = 459

 Score =  422 bits (1085), Expect = e-116
 Identities = 227/444 (51%), Positives = 294/444 (66%), Gaps = 17/444 (3%)

Query: 31  VLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQSSLIGEILHHDCASFGWNVGSVNGQVP 90
           VLD+V P+P GT WGLGGTCVNVGCIPKKLMHQ++L+G+ L  D  ++GW V     +  
Sbjct: 2   VLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQ-DSRNYGWKVE----ETV 56

Query: 91  TFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKYENVLGSFVDPHTLKLWHPKKGTKEITT 150
             DW +++  V            V LR K+V YEN  G F+ PH +K  + K   K  + 
Sbjct: 57  KHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKDKEKIYSA 116

Query: 151 RHVVIAVGGRPRQLACLGG-ELAVSSDDIFWMKQKEPGKTLVVGASYVALECAGFLKGMG 209
              +IA G RPR L   G  E  +SSDD+F +    PGKTLVVGASYVALECAGFL G+G
Sbjct: 117 ERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC-PGKTLVVGASYVALECAGFLAGIG 175

Query: 210 YAVKVMVRSILLRGFDQDMASKIGEYMEMQSGIEFIRKTVPQSITKLDSGQ----LLVKW 265
             V VMVRSILLRGFDQDMA+KIGE+ME + GI+FIR+ VP  + ++++G      +V  
Sbjct: 176 LDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQ 234

Query: 266 ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKLNEKTGRIWV-NNEQTTTPNVYAI 324
            T   +  E  ++TV+ A GRD    K+GL+  GVK+NEKTG+I V + EQT  P +YAI
Sbjct: 235 STNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAI 294

Query: 325 GDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKE 383
           GD++ D  ELTPVAIQAGRLL++RLY   TV+ DY+ + T VFTP+EYG CGLSEE + E
Sbjct: 295 GDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVE 354

Query: 384 EYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVT 443
           ++G++++EVYH  F PLEW++  +       CY K++C+   N  V+GFH LGPNAGEVT
Sbjct: 355 KFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAKIICNTKDNERVVGFHVLGPNAGEVT 411

Query: 444 QAMGLAMKLGFTYDQLVDTVGIHP 467
           Q    A+K G T  QL  T+GIHP
Sbjct: 412 QGFAAALKCGLTKKQLDSTIGIHP 435


>gb|EFV61343.1| thioredoxin reductase 1, cytoplasmic [Trichinella spiralis]
          Length = 598

 Score =  421 bits (1083), Expect = e-115
 Identities = 230/473 (48%), Positives = 308/473 (65%), Gaps = 15/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YDLVVIGGGSGGLA +K+AA  GK+V VLD+V P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 110 HQYDLVVIGGGSGGLAAAKDAALAGKRVAVLDFVTPTPLGTTWGLGGTCVNVGCIPKKLM 169

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           H +SL+G+ L  D   FGW  G    +     W  +V+ +            V+LR K V
Sbjct: 170 HCTSLLGKNLA-DARKFGWKYG----EEVKHSWTDMVTAIQSHITALNWNYRVQLREKSV 224

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDIFW 180
            Y N  G+FV  H++K    +   + IT+   +IA G RPR L   G  E  ++SDD+F 
Sbjct: 225 TYLNAFGTFVGSHSIKATDKRNKEQIITSDRFIIATGLRPRYLDVPGVKEYCITSDDLFS 284

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTL VGASYV+LECAGFL+G+G  V VMVRSILLRGFDQDMA++IG +M+   
Sbjct: 285 LPYC-PGKTLCVGASYVSLECAGFLRGLGLDVTVMVRSILLRGFDQDMANRIGNHMQTVE 343

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWIT---EDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
           G+ FI K +P  I +L  GQ  +  +T   EDG+   + ++TVL A GRD     L LD+
Sbjct: 344 GVRFIYKCIPTKIERLQDGQPGLFRVTAKKEDGEEVVDEYNTVLIAIGRDALTDALNLDK 403

Query: 298 AGVKLNEKTGRI--WVNNEQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRLYNEGTV 354
            GV+ N +  +I  + N + TT P +YAIGDV+D   ELTPVAI+AGRLL++R++   ++
Sbjct: 404 VGVETNPENKKILCYANEQSTTAPYIYAIGDVLDRGLELTPVAIKAGRLLAKRMFGLSSI 463

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
             D     T VFTP+EYGCCG+SEE++ EEYG+ ++EV+H  F PLE+++ +  R  +E 
Sbjct: 464 LCDRYLTPTTVFTPLEYGCCGMSEEEAIEEYGEINIEVFHSYFTPLEYTVPK--RDDSEH 521

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY K++C+K  +  +LGFH LGPNAGE+TQ   + +KL  T       VGIHP
Sbjct: 522 CYAKLICNKQDDMRILGFHLLGPNAGEITQGFAIGLKLKATKHDFDLLVGIHP 574


>gb|AAN32903.1| thioredoxin reductase TR1 [Chlamydomonas reinhardtii]
          Length = 533

 Score =  421 bits (1083), Expect = e-115
 Identities = 243/504 (48%), Positives = 308/504 (61%), Gaps = 46/504 (9%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +Y+YDLVVIGGGSGGLAC+KEAA  GKKVC+LDYV PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 13  AYEYDLVVIGGGSGGLACAKEAAKLGKKVCLLDYVVPSPAGTSWGLGGTCVNVGCIPKKL 72

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH + L+GE    D   +GW +     +    +W+ LV  V            V LR   
Sbjct: 73  MHNAGLLGEGF-SDARGYGWKL----PEKIEMNWEDLVMGVQNHIGSLNWGYRVALREAS 127

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKE-ITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           VKY N  GSFVD HT++    + GTK  +T   VVIAVGGRP+ L   G  EL ++SDDI
Sbjct: 128 VKYLNAKGSFVDAHTVEAVE-RNGTKHTLTAERVVIAVGGRPKYLGVPGDKELCITSDDI 186

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F  +   PGKTLVVGASY+ALECAGFL+ +GY V VM RSI LRGFDQ++A  IG+ ME 
Sbjct: 187 F-SRATPPGKTLVVGASYIALECAGFLRALGYEVAVMARSIFLRGFDQEIAELIGKDME- 244

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITED-GDCFEETFDTVLNATGRDPDVAKLGLDE 297
           + G+  I+  VP +  + D  Q+   +   D G    E+FDTVL A GRD     LGL++
Sbjct: 245 RRGVRMIKPAVPTAFER-DGEQIKCTFKNLDFGVEMSESFDTVLLAVGRDACTFDLGLEK 303

Query: 298 AGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID---------------------------- 329
            GV  ++ +G+I V  EQT  P++YAIGDV++                            
Sbjct: 304 VGVTYDKSSGKIPVTAEQTNVPSIYAIGDVLESRQVPGQGGRKLMGLTCSLAQTLSPPDP 363

Query: 330 -APELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDD 388
            A ELTPVAI+AG  L+RRLY   T+QMDYD + T VFTP+EYGC G SEE +  +YG D
Sbjct: 364 LAQELTPVAIKAGIRLARRLYAGATLQMDYDAVPTTVFTPLEYGCVGYSEEAATVKYGAD 423

Query: 389 SVEVYHKNFVPLEWSLAEQTR-----IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVT 443
           ++EVY     PLEW++  +        A  S +VK++ +   N  V+G HYLGPNAGE+ 
Sbjct: 424 NIEVYVSYLKPLEWTMNHEEHNGEPVRADNSVFVKLITNTADNERVVGAHYLGPNAGEII 483

Query: 444 QAMGLAMKLGFTYDQLVDTVGIHP 467
           Q + +A+K   T     D +GIHP
Sbjct: 484 QGVAVAVKANATKADFDDCIGIHP 507


>ref|XP_002154390.1| PREDICTED: similar to MGC81848 protein [Hydra magnipapillata]
          Length = 591

 Score =  421 bits (1082), Expect = e-115
 Identities = 228/473 (48%), Positives = 303/473 (64%), Gaps = 17/473 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL VIGGGSGGLACSKEAA  G KV V D+V PSP G++WGLGGTCVNVGCIPKKLM
Sbjct: 105 YDFDLFVIGGGSGGLACSKEAADLGAKVAVADFVVPSPAGSTWGLGGTCVNVGCIPKKLM 164

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+GE + HD   +GWN+     +  + DW ++V  +            V LR K V
Sbjct: 165 HQAALLGEAI-HDSRHYGWNI----EENISHDWAKMVDAIQQHIRSLNWGYKVNLRQKNV 219

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           KY N+  +F+D HTL+L       + +T    V+A GGRP      G  E A++SDDIF 
Sbjct: 220 KYYNMYATFLDNHTLQLTDKSGKVETVTADKFVLATGGRPTYPDIPGAKECAITSDDIFS 279

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGK L  GASY+ALECAGF  G+G    VM+RSI LRGFDQ MA+K+ +YME   
Sbjct: 280 LPY-VPGKVLFCGASYIALECAGFTHGIGMDTTVMMRSIPLRGFDQFMANKVVDYME-TI 337

Query: 241 GIEFIRKTVPQSITKLDS---GQLLVKWITEDGDCFE-ETFDTVLNATGRDPDVAKLGLD 296
           GI+F++K  P  + K++    G++ V ++  + +  E + F+TV+ A GR P    LGL+
Sbjct: 338 GIKFLKKYTPIKMEKVEEGTPGKIKVTYMNHNTNEEESDIFNTVVVAIGRSPCTKGLGLE 397

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
             GVKLN   G +  +  ++T   N+Y IGD++D  PELTPVAIQAG+LL++RL+N   V
Sbjct: 398 NLGVKLNPLNGFLISDEYDRTNIENIYGIGDILDGKPELTPVAIQAGKLLAKRLFNGSKV 457

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
             DY  + T VFTP+EYG CGLSEE + E+YG+D++EVYH NF PLE ++  +       
Sbjct: 458 TCDYTNVATTVFTPLEYGACGLSEETAIEKYGEDNIEVYHSNFTPLEATVPHR---LDNV 514

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY KV+C+K     +LG H LGPNAGE+ Q   +A K+G     L D +GIHP
Sbjct: 515 CYAKVICNKKDEERILGMHVLGPNAGEIIQGFSIAFKVGAKKQHLDDLIGIHP 567


>ref|XP_002028236.1| GL23230 [Drosophila persimilis]
 gb|EDW39395.1| GL23230 [Drosophila persimilis]
          Length = 512

 Score =  421 bits (1082), Expect = e-115
 Identities = 234/473 (49%), Positives = 313/473 (66%), Gaps = 21/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEA   G +V   DYVKP+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 28  YDYDLVVLGGGSAGLACAKEAVDNGARVLCFDYVKPTPVGTKWGLGGTCVNVGCIPKKLM 87

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE +H +  ++GWNV   N +    DW++LV +V            V+LR K+V
Sbjct: 88  HQASLLGEAVH-EAVAYGWNVNDQNIKP---DWQKLVKSVQNHIKSVNWVTRVDLRDKKV 143

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE-ITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           +Y N +G+FVDPHT++ +  K G K+  T  +VV+AVGGRPR    LG  E  ++SDDIF
Sbjct: 144 EYVNSMGAFVDPHTIE-YSVKGGPKQQATAEYVVVAVGGRPRYPPILGATEFGITSDDIF 202

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
               +EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M S++ E M  +
Sbjct: 203 -SYDREPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQM-SELLEAMMSE 260

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW---ITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
            G++F+  T+P S+ +   G+LLVK+    TE  D   + FDTVL A GR   +  L L 
Sbjct: 261 RGVQFLHTTIPSSVERQGDGRLLVKYRNTTTEKED--SDVFDTVLWAIGRKGLIEDLNLP 318

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
            AGV+   K  +I V++ E T  P+++A+GD+I   PEL+PVAI +GRLL+RRL+     
Sbjct: 319 AAGVE--TKNDKIVVDSTEATNVPHIFAVGDIIHGRPELSPVAILSGRLLARRLFAGSKQ 376

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EY C G+SEE + + +G D++EV+H  + P E+ +    R +   
Sbjct: 377 LMDYADVATTVFTPLEYSCVGMSEEMAIQTHGPDNIEVFHGYYKPTEFFI---PRKSVRH 433

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K V + T +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 434 CYLKAVAEITGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 486


>ref|XP_001352389.2| GA10979 [Drosophila pseudoobscura pseudoobscura]
 gb|EAL29885.2| GA10979 [Drosophila pseudoobscura pseudoobscura]
          Length = 512

 Score =  421 bits (1081), Expect = e-115
 Identities = 234/473 (49%), Positives = 313/473 (66%), Gaps = 21/473 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEA   G +V   DYVKP+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 28  YDYDLVVLGGGSAGLACAKEAVDNGARVLCFDYVKPTPVGTKWGLGGTCVNVGCIPKKLM 87

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE +H +  ++GWNV   N +    DW++LV +V            V+LR K+V
Sbjct: 88  HQASLLGEAVH-EAVAYGWNVNDQNIKP---DWQKLVKSVQNHIKSVNWVTRVDLRDKKV 143

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE-ITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           +Y N +G+FVDPHT++ +  K G K+  T  +VV+AVGGRPR    LG  E  ++SDDIF
Sbjct: 144 EYVNSMGTFVDPHTIE-YSVKGGPKQQATAAYVVVAVGGRPRYPPILGATEFGITSDDIF 202

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
               +EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M S++ E M  +
Sbjct: 203 -SYDREPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQM-SELLEAMMSE 260

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW---ITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
            G++F+  T+P S+ +   G+LLVK+    TE  D   + FDTVL A GR   +  L L 
Sbjct: 261 RGVQFLHTTIPSSVERQGDGRLLVKYRNTTTEKED--SDVFDTVLWAIGRKGLIEDLNLP 318

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
            AGV+   K  +I V++ E T  P+++A+GD+I   PEL+PVAI +GRLL+RRL+     
Sbjct: 319 AAGVE--TKNDKIVVDSKEATNVPHIFAVGDIIHGRPELSPVAILSGRLLARRLFAGSKQ 376

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY  + T VFTP+EY C G+SEE + + +G D++EV+H  + P E+ +    R +   
Sbjct: 377 LMDYADVATTVFTPLEYSCVGMSEEMAIQTHGPDNIEVFHGYYKPTEFFI---PRKSVRH 433

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K V + T +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 434 CYLKAVAEITGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 486


>dbj|BAH12374.1| unnamed protein product [Homo sapiens]
          Length = 459

 Score =  420 bits (1080), Expect = e-115
 Identities = 226/444 (50%), Positives = 293/444 (65%), Gaps = 17/444 (3%)

Query: 31  VLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQSSLIGEILHHDCASFGWNVGSVNGQVP 90
           VLD+V P+P GT WGLGGTCVNVGCIPKKLMHQ++L+G+ L  D  ++GW V     +  
Sbjct: 2   VLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQ-DSRNYGWKVE----ETV 56

Query: 91  TFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKYENVLGSFVDPHTLKLWHPKKGTKEITT 150
             DW +++  V            V LR K+V YEN  G F+ PH +K  + K   K  + 
Sbjct: 57  KHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSA 116

Query: 151 RHVVIAVGGRPRQLACLGG-ELAVSSDDIFWMKQKEPGKTLVVGASYVALECAGFLKGMG 209
              +IA G RPR L   G  E  +SSDD+F +    PGKTLVVGASYVALECAGFL G+G
Sbjct: 117 ERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYC-PGKTLVVGASYVALECAGFLAGIG 175

Query: 210 YAVKVMVRSILLRGFDQDMASKIGEYMEMQSGIEFIRKTVPQSITKLDSGQ----LLVKW 265
             V VMVRSILLRGFDQDMA+KIGE+ME + GI+FIR+ VP  + ++++G      +V  
Sbjct: 176 LDVTVMVRSILLRGFDQDMANKIGEHME-EHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQ 234

Query: 266 ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKLNEKTGRIWV-NNEQTTTPNVYAI 324
            T   +  E  ++T + A GRD    K+GL+  GVK+NEKTG+I V + EQT  P +YAI
Sbjct: 235 STNSEEIIEGEYNTAMLAMGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAI 294

Query: 325 GDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKE 383
           GD++ D  ELTPVAIQAGRLL++RLY   TV+ DY+ + T VFTP+EYG CGLSEE + E
Sbjct: 295 GDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVE 354

Query: 384 EYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVT 443
           ++G++++EVYH  F PLEW++  +       CY K++C+   N  V+GFH LGPNAGEVT
Sbjct: 355 KFGEENIEVYHSYFWPLEWTIPSRDN---NKCYAKIICNTKDNERVVGFHVLGPNAGEVT 411

Query: 444 QAMGLAMKLGFTYDQLVDTVGIHP 467
           Q    A+K G T  QL  T+GIHP
Sbjct: 412 QGFAAALKCGLTKKQLDSTIGIHP 435


>gb|AAN63052.1| thioredoxin glutathione reductase [Echinococcus granulosus]
          Length = 597

 Score =  420 bits (1080), Expect = e-115
 Identities = 228/477 (47%), Positives = 306/477 (64%), Gaps = 24/477 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYD+V+IGGGSGGLA +KE+A  G KV +LD+V P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 108 YDYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNVGCIPKKLM 167

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+   +  D  SFGW+V          DW ++V  +              + +  V
Sbjct: 168 HQAALLNHYME-DAKSFGWDVDK-----GPHDWVKMVEGIQDHIHALNFGYRSSMMNANV 221

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           KY N LG  VDPHT+K  + +   K ITT  +++A G RPR     G  E  ++SDD+F 
Sbjct: 222 KYLNALGEIVDPHTIKTTNKQGIVKNITTNTIIVATGERPRYPPIPGAKEYGITSDDLFT 281

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTL VGASYV+LECAGFL  +G  V VMVRSI LRGFDQ MA  I +Y+  + 
Sbjct: 282 LDHN-PGKTLCVGASYVSLECAGFLSSIGCDVTVMVRSIFLRGFDQQMAGLISDYI-AKY 339

Query: 241 GIEFIRKTVPQSITKL-----DSGQLLVKWIT---EDGDCFEETFDTVLNATGRDPDVAK 292
           G++F+R  VP S+  L     +SG+L +  +    EDG  F++TF+TVL A GRDP    
Sbjct: 340 GVKFVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDPCTTN 399

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQ-TTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYN 350
           +GL    VK     GR+ V++E+ T  PN+YAIGDV +A  +LTP+AIQAG+ L+RRLY 
Sbjct: 400 IGLQNVDVKTT--NGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARRLYT 457

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
               + DY  + T VFTP+EYGC GLSEE++  ++G+D++EV+H  F PLEW++  +   
Sbjct: 458 ADDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPHR--- 514

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              +CY K++ +K  +N V+GFH  GPNAGEVTQ   +AM LG   +    T+GIHP
Sbjct: 515 PDNTCYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHP 571


>gb|AAN63051.1| thioredoxin glutathione reductase [Echinococcus granulosus]
          Length = 624

 Score =  420 bits (1080), Expect = e-115
 Identities = 228/477 (47%), Positives = 306/477 (64%), Gaps = 24/477 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYD+V+IGGGSGGLA +KE+A  G KV +LD+V P+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 135 YDYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNVGCIPKKLM 194

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+   +  D  SFGW+V          DW ++V  +              + +  V
Sbjct: 195 HQAALLNHYME-DAKSFGWDVDK-----GPHDWVKMVEGIQDHIHALNFGYRSSMMNANV 248

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           KY N LG  VDPHT+K  + +   K ITT  +++A G RPR     G  E  ++SDD+F 
Sbjct: 249 KYLNALGEIVDPHTIKTTNKQGIVKNITTNTIIVATGERPRYPPIPGAKEYGITSDDLFT 308

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTL VGASYV+LECAGFL  +G  V VMVRSI LRGFDQ MA  I +Y+  + 
Sbjct: 309 LDHN-PGKTLCVGASYVSLECAGFLSSIGCDVTVMVRSIFLRGFDQQMAGLISDYI-AKY 366

Query: 241 GIEFIRKTVPQSITKL-----DSGQLLVKWIT---EDGDCFEETFDTVLNATGRDPDVAK 292
           G++F+R  VP S+  L     +SG+L +  +    EDG  F++TF+TVL A GRDP    
Sbjct: 367 GVKFVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDPCTTN 426

Query: 293 LGLDEAGVKLNEKTGRIWVNNEQ-TTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYN 350
           +GL    VK     GR+ V++E+ T  PN+YAIGDV +A  +LTP+AIQAG+ L+RRLY 
Sbjct: 427 IGLQNVDVKTT--NGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARRLYT 484

Query: 351 EGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRI 410
               + DY  + T VFTP+EYGC GLSEE++  ++G+D++EV+H  F PLEW++  +   
Sbjct: 485 ADDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPHR--- 541

Query: 411 AAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              +CY K++ +K  +N V+GFH  GPNAGEVTQ   +AM LG   +    T+GIHP
Sbjct: 542 PDNTCYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHP 598


>dbj|BAE72986.1| hypothetical protein [Macaca fascicularis]
          Length = 499

 Score =  419 bits (1078), Expect = e-115
 Identities = 233/468 (49%), Positives = 304/468 (64%), Gaps = 23/468 (4%)

Query: 9   IGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQSSLIG 68
           + GG  G A    AA  G+KV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ++L+G
Sbjct: 22  VAGGVRGAARGAAAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLG 81

Query: 69  EILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKYENVLG 128
            ++  D   +GW V     Q    DW+++   V            V+L+ ++VKY N+  
Sbjct: 82  GLIQ-DAPHYGWEVA----QPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKA 136

Query: 129 SFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDIFWMKQK 184
           SFVD HT+      KG KEI  +  H++IA GGRPR    + G  E  ++SDDIFW+K+ 
Sbjct: 137 SFVDEHTV--CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKES 194

Query: 185 EPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSGIEF 244
            PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+M    G +F
Sbjct: 195 -PGKTLVVGASYVALECAGFLTGIGLDTTVMIRSIPLRGFDQQMSSMVIEHMASH-GTQF 252

Query: 245 IRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLDEAGVK 301
           +R   P  + +L  G L V W  ED    +E   TFDTVL A GR PD   L L++AGV 
Sbjct: 253 LRGCAPSRVRRLPDGHLQVTW--EDCTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVD 310

Query: 302 LNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
            +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +  MDYD
Sbjct: 311 TSPDTQKILVDSREGTSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYD 370

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKV 419
            + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A  CYVK+
Sbjct: 371 NVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---ASQCYVKM 427

Query: 420 VCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           VC +     VLG H+LGPNAGEVTQ + L +K G +Y Q++ TVGIHP
Sbjct: 428 VCLREPPQLVLGLHFLGPNAGEVTQGLALGIKCGASYAQVMRTVGIHP 475


>ref|XP_002423998.1| thioredoxin reductase, putative [Pediculus humanus corporis]
 gb|EEB11260.1| thioredoxin reductase, putative [Pediculus humanus corporis]
          Length = 802

 Score =  419 bits (1076), Expect = e-115
 Identities = 226/471 (47%), Positives = 307/471 (65%), Gaps = 15/471 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGSGGLA +KEAA+ G+ V + D+VKP+P GT+WGLGGTCVNVGCIPKKLM
Sbjct: 317 YDYDLVVVGGGSGGLAAAKEAATLGRTVALCDFVKPTPMGTTWGLGGTCVNVGCIPKKLM 376

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+S+  E  HHD +SFGWN  + +G      W+ +V NV             EL  ++V
Sbjct: 377 HQASIHAEN-HHDSSSFGWNFHTSDGH---HTWETMVENVQNYIKSLNFGYRKELNKRKV 432

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           KY N    FV PH LKL + K    E++ + ++IAVGGRP      G  E  ++SDD+F 
Sbjct: 433 KYLNAYAEFVAPHKLKLTNKKGEVSEVSAKDIIIAVGGRPAYPNVPGAKEFCITSDDLFS 492

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +  K PGKTL+VGASY+ALEC GFLKG+GY V +MVRSILLRGFD+ +A  IGE+ME + 
Sbjct: 493 LS-KPPGKTLIVGASYIALECGGFLKGLGYDVTIMVRSILLRGFDRQIADLIGEHME-KI 550

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGD-CFEETFDTVLNATGRDPDVAKLGLDE-A 298
           GI+F+++  P    K + G++ V   ++ GD      FDTV+ A GR+    KLGL+   
Sbjct: 551 GIKFVKEYEPIGFNKTNEGKIKVAAKSKKGDEIVVSGFDTVVLAIGREACTGKLGLENLP 610

Query: 299 GVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
            +K+N K  +I V+  E+++ P+VYAIGDVID  PELTPVAI AG+ L++R+        
Sbjct: 611 NLKINPKNKKIIVDEFERSSVPHVYAIGDVIDGKPELTPVAIHAGKYLAQRICGVHNKTT 670

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           +Y ++ T VFTP+EYG  GLSEE++   +G +++ VYH  F PLE +L+ +  +     Y
Sbjct: 671 NYKQVPTTVFTPLEYGTVGLSEEEAFNIFGKENIVVYHNAFKPLEHALSREDTLG----Y 726

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            K++C K+    V+GFH L PNAGE+TQ   +A+KL        D +GIHP
Sbjct: 727 AKLICVKSLEELVVGFHVLSPNAGEITQGYAIALKLNAKKSDFDDLIGIHP 777


>dbj|BAE28994.1| unnamed protein product [Mus musculus]
          Length = 431

 Score =  416 bits (1070), Expect = e-114
 Identities = 225/429 (52%), Positives = 289/429 (67%), Gaps = 17/429 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SYD+DL++IGGGSGGLA +KEAA F KKV VLD+V P+P GT WGLGGTCVNVGCIPKKL
Sbjct: 10  SYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTPLGTRWGLGGTCVNVGCIPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D  ++GW V          DW+++  +V            V LR K+
Sbjct: 70  MHQAALLGQALK-DSRNYGWKVEDT----VKHDWEKMTESVQSHIGSLNWGYRVALREKE 124

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V YEN  G F+ PH +   + K   K  +    +IA G RPR L   G  E  +SSDD+F
Sbjct: 125 VVYENAYGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQDMA+KIGE+ME +
Sbjct: 185 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHME-E 242

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEET----FDTVLNATGRDPDVAKLGL 295
            GI+FIR+ VP  I ++++G      +T      EET    F+TVL A GRD     +GL
Sbjct: 243 HGIKFIRQFVPTKIEQIEAGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGL 302

Query: 296 DEAGVKLNEKTGRIWV-NNEQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           +  GVK+NEKTG+I V + EQT  P +YAIGD+++   ELTPVAIQAGRLL++RLY    
Sbjct: 303 ETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSN 362

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
           V+ DYD + T VFTP+EYGCCGLSEE + E++G++++EVYH  F PLEW++  +      
Sbjct: 363 VKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDN---N 419

Query: 414 SCYVKVVCD 422
            CY K++C+
Sbjct: 420 KCYAKIICN 428


>ref|XP_002773322.1| thioredoxin reductase 1, cytoplasmic, putative [Perkinsus marinus
           ATCC 50983]
 gb|EER05138.1| thioredoxin reductase 1, cytoplasmic, putative [Perkinsus marinus
           ATCC 50983]
          Length = 495

 Score =  416 bits (1069), Expect = e-114
 Identities = 233/474 (49%), Positives = 299/474 (63%), Gaps = 20/474 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YD+DL VIGGGSGGLA +K AA+ G +V + D+VKPSP GT+WGLGGTCVNVGCIPKKL+
Sbjct: 9   YDWDLFVIGGGSGGLAAAKTAAALGARVALADFVKPSPQGTTWGLGGTCVNVGCIPKKLL 68

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           H S+   E    D A  GW + +      + +W+ ++ NV             ELRS  V
Sbjct: 69  HMSAHTAETAG-DSAGLGWELTA------SHNWEAMIQNVTTYISSLNWGYKSELRSTNV 121

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDIFW 180
           KY N   +F+D +TLKL   +     +T R+++IA GGRP      G GE  ++SDDIF 
Sbjct: 122 KYFNSFATFIDRNTLKLTDKRGKESIVTARYILIATGGRPNLGGYPGAGECCITSDDIF- 180

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
            ++  PGKTLVVGASY+ALECAGF+ G GY   VMVRSILLRGFDQDMA +IG+YME+  
Sbjct: 181 RRKAPPGKTLVVGASYIALECAGFIAGFGYDTTVMVRSILLRGFDQDMAQRIGKYMELH- 239

Query: 241 GIEFIRKTVPQSITKLDSGQLLV-----KWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
           G +F+ + +P    K + G++ V          D D     FDTVL A GR      L L
Sbjct: 240 GTKFVHEMIPTKFEKTEDGKVRVYAKSSSDTMSDADSEFGVFDTVLMAVGRTGCAGWLSL 299

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           D AGV  N   G+I V+  E T   N+YAIGDV++   ELTPVAIQ+G++L+ RL+   +
Sbjct: 300 DNAGVHYNPDKGKIPVDKFEMTNIDNIYAIGDVVEGMLELTPVAIQSGKMLAARLFGGAS 359

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDY  + T VFTPIEYG  G SEE++KEEYGDD + VYH  F PL W+L +    A  
Sbjct: 360 RLMDYHNVPTTVFTPIEYGSVGSSEENAKEEYGDDLI-VYHSFFKPLLWALNKDRGDA-- 416

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY+KV+C+   +  V+G H LGP+AGE+ Q + +AMK G T   L DTVGIHP
Sbjct: 417 DCYMKVLCENKGDKKVVGIHILGPDAGEMIQGLAVAMKAGCTKANLDDTVGIHP 470


>ref|XP_001958552.1| GF23459 [Drosophila ananassae]
 gb|EDV41358.1| GF23459 [Drosophila ananassae]
          Length = 514

 Score =  416 bits (1068), Expect = e-114
 Identities = 229/475 (48%), Positives = 310/475 (65%), Gaps = 24/475 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGS GLAC+KEA   G +V   DYVKP+P GT WGLGGTCVNVGCIPKKLM
Sbjct: 29  FDYDLVVLGGGSAGLACAKEAVDCGARVLCFDYVKPTPVGTKWGLGGTCVNVGCIPKKLM 88

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GWNV   N +    DW +LV +V            V+LR K+V
Sbjct: 89  HQASLLGEAV-HEAVAYGWNVNDKNIRP---DWCKLVRSVQNHIKSVNWVTRVDLRDKKV 144

Query: 122 KYENVLGSFVDPHTLKLWHPKKG--TKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
           +Y N +G+FVD HT++ + PK G     +T ++VV+AVGGRPR  +  G  E  ++SDDI
Sbjct: 145 EYVNSMGAFVDGHTIE-YVPKSGQAKSRVTAKNVVVAVGGRPRYPSIPGATEFGITSDDI 203

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F    +EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M  
Sbjct: 204 F-SYDREPGRTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSELLAAMMS- 261

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKW----ITEDGDCFEETFDTVLNATGRDPDVAKLG 294
           + GI F+  T+P S+ +   G+LLV++       DG    + FDTVL A GR   +  L 
Sbjct: 262 ERGISFLETTIPSSVERQSDGRLLVRFRNTTTQTDG---SDVFDTVLWAIGRRGLIEDLN 318

Query: 295 LDEAGVKL-NEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L+ AGVK  N+K   +   +E T  P+++A+GD++   PELTPVAI AGRLL+RRL+   
Sbjct: 319 LEAAGVKTQNDKI--VVDRSEATNVPHIFAVGDIVYGRPELTPVAILAGRLLARRLFAGS 376

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
           T  MDY  + T VFTP+EY C G+SEE + E++G D++EV+H  + P E+ + ++   + 
Sbjct: 377 TQLMDYADVATTVFTPLEYACVGMSEETAIEKHGADNIEVFHGYYKPTEFFIPQK---SV 433

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             CY+K V +   +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 434 RFCYLKAVAEIAGDQKILGLHYMGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 488


>ref|XP_001973742.1| GG16263 [Drosophila erecta]
 gb|EDV52768.1| GG16263 [Drosophila erecta]
          Length = 518

 Score =  415 bits (1067), Expect = e-114
 Identities = 228/474 (48%), Positives = 314/474 (66%), Gaps = 20/474 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GWNV   N +    DW++LV +V            V+LR K+V
Sbjct: 91  HQASLLGEAV-HEAVAYGWNVDDKNLRP---DWRKLVRSVQNHIKSVNWVTRVDLRDKKV 146

Query: 122 KYENVLGSFVDPHTLKL---WHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDD 177
           +Y N +GSF D HT++      P   ++++T+ +VV+AVGGRPR     G  EL ++SDD
Sbjct: 147 EYVNSMGSFRDSHTIEYVASTSPGAESRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDD 206

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           IF   ++EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M 
Sbjct: 207 IF-SYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSDLLAAMM- 264

Query: 238 MQSGIEFIRKTVPQSITKLDSGQLLVKW--ITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            + GI F+  T+P+++ +   G+LLV++   T   D   + FDTVL A GR   + +L L
Sbjct: 265 TERGIPFLGTTIPKAVERQADGRLLVRYRNTTTQAD-GSDVFDTVLWAIGRKGLIEELNL 323

Query: 296 DEAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           + AGV+  +   +I V+  E T+ P+++A+GD+I   PELTPVAI AGRLL+RRL+   T
Sbjct: 324 EAAGVRTQD--DKIVVDAAEATSVPHIFAVGDIIFGRPELTPVAILAGRLLARRLFAGAT 381

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EY C G+SEE +    G D++EV+H  + P E+ + ++   +  
Sbjct: 382 QLMDYDDVATTVFTPLEYSCVGMSEETAIALRGADNIEVFHGYYKPTEFFIPQK---SVR 438

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY+K V + + +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 439 HCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 492


>gb|EAX03014.1| hCG17888, isoform CRA_b [Homo sapiens]
          Length = 473

 Score =  414 bits (1064), Expect = e-113
 Identities = 233/474 (49%), Positives = 303/474 (63%), Gaps = 42/474 (8%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 9   DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 49

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 50  QAALLGGLIQ-DAPNYGWEVA----QPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 104

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT+      KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 105 YFNIKASFVDEHTV--CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 162

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 163 FWLKES-PGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 221

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 222 H-GTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 278

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 279 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 338

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 339 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 395

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 396 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 449


>gb|EAX03013.1| hCG17888, isoform CRA_a [Homo sapiens]
          Length = 503

 Score =  414 bits (1064), Expect = e-113
 Identities = 233/474 (49%), Positives = 303/474 (63%), Gaps = 42/474 (8%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 80  QAALLGGLIQ-DAPNYGWEVA----QPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 134

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT+      KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 135 YFNIKASFVDEHTV--CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 192

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 193 FWLKES-PGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 251

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 252 H-GTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 308

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 309 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 368

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 369 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 425

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 426 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 479


>gb|DAA20379.1| thioredoxin reductase 2, mitochondrial precursor [Bos taurus]
          Length = 460

 Score =  412 bits (1059), Expect = e-113
 Identities = 228/446 (51%), Positives = 293/446 (65%), Gaps = 20/446 (4%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           YDL+VIGGGSGGLAC+KEAA  GKKV VLDYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 28  YDLLVIGGGSGGLACAKEAAQLGKKVAVLDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQ 87

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q P   W  L   V            ++L+ ++VKY
Sbjct: 88  AALLGGMI-RDAPHYGWGV----AQAP-HSWATLADAVQNHVKSLNWGHRIQLQDRKVKY 141

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            NV  SFVD HT  +    KG +E  ++  H+VIA GGRPR    + G  E  ++SDD+F
Sbjct: 142 FNVKASFVDTHT--VCGVSKGGEETLLSAEHIVIATGGRPRYPTHIEGALEYGITSDDLF 199

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAG L G+G    VM+RS+ LR FDQ MAS + E+M   
Sbjct: 200 WLKE-SPGKTLVVGASYVALECAGLLTGLGLDTTVMIRSVPLRAFDQQMASLVTEHM-AG 257

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE-TFDTVLNATGRDPDVAKLGLDEA 298
            G   +R   P+ + KL   QL V W+    D  +  TFDTVL A GR P+ A L L++A
Sbjct: 258 HGTRILRGCAPEKVEKLPGQQLRVTWVDLTSDRKDAGTFDTVLWAIGRVPETASLNLEKA 317

Query: 299 GVKLNEKTGRIWVNNEQTTT-PNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV  N  TG+I V+ ++TT+ P++YAIGDV +  PELTP AI AGRLL++RL    +  M
Sbjct: 318 GVHTNPVTGKILVDAQETTSVPHIYAIGDVAEGRPELTPTAIMAGRLLAQRLSGRTSDLM 377

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           DY  + T VFTP+EYGC GLSEE +   +G++ VEVYH  + PLE+++ ++    A  CY
Sbjct: 378 DYSSVPTTVFTPLEYGCVGLSEEAAVARHGEEHVEVYHAFYKPLEFTVPQRD---ASQCY 434

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEV 442
           +K+VC +     VLG H+LGPNAGEV
Sbjct: 435 IKMVCLREPPQLVLGLHFLGPNAGEV 460


>ref|XP_002086704.1| GE23284 [Drosophila yakuba]
 gb|EDX00106.1| GE23284 [Drosophila yakuba]
          Length = 516

 Score =  412 bits (1059), Expect = e-113
 Identities = 227/474 (47%), Positives = 314/474 (66%), Gaps = 22/474 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GWNV   N +    DW++LV +V            V+LR K+V
Sbjct: 91  HQASLLGEAV-HEAVAYGWNVDDQNLRP---DWRKLVRSVQNHIKSVNWVTRVDLRDKKV 146

Query: 122 KYENVLGSFVDPHTLK-LWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           +Y N + SF D HT++ +  P    +++T+ +VV+AVGGRPR     G  EL ++SDDIF
Sbjct: 147 EYVNSMCSFRDSHTIEYVAMPGAENRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIF 206

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
              ++EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M  +
Sbjct: 207 -SYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TE 264

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW----ITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI F+  T+P+++ +   G+LLV++      +DG    + FDTVL A GR   +  L L
Sbjct: 265 RGIPFLGTTIPKAVERQADGRLLVRYHNTTTQKDG---SDVFDTVLWAIGRKGLIEDLNL 321

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           + AGVK ++   +I V+  E T+ P+++A+GD+I   PELTPVAI +GRLL+RRL+   T
Sbjct: 322 EAAGVKTHD--DKIVVDGAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGST 379

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDY  + T VFTP+EY C G+SEE + E  G D++EV+H  + P E+ + ++   +  
Sbjct: 380 QLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQK---SVR 436

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY+K V + + +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 437 HCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 490


>ref|NP_524216.1| thioredoxin reductase 2 [Drosophila melanogaster]
 sp|Q9VNT5|TRXR2_DROME RecName: Full=Thioredoxin reductase 2, mitochondrial; Short=TrxR-2;
           Flags: Precursor
 gb|AAF64152.1|AF236866_1 thioredoxin reductase 2 [Drosophila melanogaster]
 gb|AAF51835.1| thioredoxin reductase 2 [Drosophila melanogaster]
 gb|AAM51940.1| AT28243p [Drosophila melanogaster]
 gb|ACL87413.1| Trxr-2-PA [synthetic construct]
          Length = 516

 Score =  412 bits (1059), Expect = e-113
 Identities = 227/474 (47%), Positives = 313/474 (66%), Gaps = 22/474 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GWNV   N +    DW++LV +V            V+LR K+V
Sbjct: 91  HQASLLGEAV-HEAVAYGWNVDDTNIRP---DWRKLVRSVQNHIKSVNWVTRVDLRDKKV 146

Query: 122 KYENVLGSFVDPHTLK-LWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           +Y N + +F D HT++ +  P    +++T+ +VV+AVGGRPR     G  EL ++SDDIF
Sbjct: 147 EYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIF 206

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
              ++EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M  +
Sbjct: 207 -SYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TE 264

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW----ITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI F+  T+P+++ +   G+LLV++       DG    + FDTVL A GR   +  L L
Sbjct: 265 RGIPFLGTTIPKAVERQADGRLLVRYRNTTTQMDG---SDVFDTVLWAIGRKGLIEDLNL 321

Query: 296 DEAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           D AGVK ++   +I V+  E T+ P+++A+GD+I   PELTPVAI +GRLL+RRL+   T
Sbjct: 322 DAAGVKTHD--DKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGST 379

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDY  + T VFTP+EY C G+SEE + E  G D++EV+H  + P E+ + ++   +  
Sbjct: 380 QLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQK---SVR 436

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY+K V + + +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 437 HCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHP 490


>ref|XP_002040924.1| GM22453 [Drosophila sechellia]
 gb|EDW44477.1| GM22453 [Drosophila sechellia]
          Length = 516

 Score =  412 bits (1058), Expect = e-113
 Identities = 228/474 (48%), Positives = 313/474 (66%), Gaps = 22/474 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVV+GGGS GLAC+KEAA  G +V   DYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GWNV   N +    DW +LV +V            V+LR K+V
Sbjct: 91  HQASLLGEAV-HEAVAYGWNVDDKNIRP---DWGKLVRSVQNHIKSVNWVTRVDLRDKKV 146

Query: 122 KYENVLGSFVDPHTLK-LWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           +Y N +GSF D HT++ +  P    +++T+ +VV+AVGGRPR     G  EL ++SDDIF
Sbjct: 147 EYVNSMGSFRDSHTIEYVAMPDAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIF 206

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
              ++EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M  +
Sbjct: 207 -SYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TE 264

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW----ITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI F+  T+P+++ +   G+LLV++       DG    + FDTVL A GR   +  L L
Sbjct: 265 RGIPFLGTTIPKAVERQADGRLLVRYRNTTTQMDG---SDVFDTVLWAIGRKGLIEDLNL 321

Query: 296 DEAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           + AGVK ++   +I V+  E T+ P+++A+GD+I   PELTPVAI +GRLL+RRL+   T
Sbjct: 322 EAAGVKTHD--DKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGST 379

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDY  + T VFTP+EY C G+SEE + E  G D++EV+H  + P E+ + ++   +  
Sbjct: 380 QLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQK---SVR 436

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY+K V + + +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 437 HCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 490


>gb|EAW79356.1| hCG40656, isoform CRA_b [Homo sapiens]
          Length = 459

 Score =  412 bits (1058), Expect = e-113
 Identities = 227/445 (51%), Positives = 292/445 (65%), Gaps = 19/445 (4%)

Query: 31  VLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQSSLIGEILHHDCASFGWNVGSVNGQVP 90
           VLD+V PSP GTSWGLGGTCVNVGCIPKKLMHQ++L+G+ L  D   FGW     N QV 
Sbjct: 2   VLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALC-DSRKFGWEY---NQQV- 56

Query: 91  TFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKYENVLGSFVDPHTLKLWHPKKGTKEITT 150
             +W+ +   +            + LR K V Y N  G FV+ H +K  + K      T 
Sbjct: 57  RHNWETMTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTA 116

Query: 151 RHVVIAVGGRPRQLACLGG-ELAVSSDDIFWMKQKEPGKTLVVGASYVALECAGFLKGMG 209
              VIA G RPR L   G  E  ++SDD+F +    PGKTLVVGASYVALECAGFL G G
Sbjct: 117 AQFVIATGERPRYLGIQGDKEYCITSDDLFSLPYC-PGKTLVVGASYVALECAGFLAGFG 175

Query: 210 YAVKVMVRSILLRGFDQDMASKIGEYMEMQSGIEFIRKTVPQSITKLDSG-----QLLVK 264
             V VMVRSILLRGFDQ+MA K+G YME Q G++F+RK +P  + +L+ G     ++L K
Sbjct: 176 LDVTVMVRSILLRGFDQEMAEKVGSYME-QHGVKFLRKFIPVMVQQLEKGSPGKLKVLAK 234

Query: 265 WITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKLNEKTGRIWVNN-EQTTTPNVYA 323
             TE  +  E  ++TVL A GRD    K+GL++ GVK+NEK+G+I VN+ EQT  P VYA
Sbjct: 235 -STEGTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYA 293

Query: 324 IGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSK 382
           +GD++ D PELTPVAIQ+G+LL++RL+     + DY  + T VFTP+EYGCCGLSEE + 
Sbjct: 294 VGDILEDKPELTPVAIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAI 353

Query: 383 EEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEV 442
           E Y  +++E+YH  F PLEW++A +      +CY K++C+K  ++ V+GFH LGPNAGEV
Sbjct: 354 EVYKKENLEIYHTLFWPLEWTVAGREN---NTCYAKIICNKFDHDRVIGFHILGPNAGEV 410

Query: 443 TQAMGLAMKLGFTYDQLVDTVGIHP 467
           TQ    AMK G T   L DT+GIHP
Sbjct: 411 TQGFAAAMKCGLTKQLLDDTIGIHP 435


>ref|XP_003074475.1| thioredoxin reductase TR1 (ISS) [Ostreococcus tauri]
 emb|CAL50326.1| thioredoxin reductase TR1 (ISS) [Ostreococcus tauri]
          Length = 540

 Score =  411 bits (1056), Expect = e-112
 Identities = 235/477 (49%), Positives = 299/477 (62%), Gaps = 20/477 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y+YD+VVIGGGSGGLA +KEAA  G K   LD+VKPSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 12  YEYDVVVIGGGSGGLAAAKEAAKHGAKTACLDFVKPSPAGTTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ L+GE    D   +GW + S        DW ++V  +              LR K V
Sbjct: 72  HQAGLLGESF-SDAREYGWKLASEG-----HDWPKMVEQIQNHIGSLNFGYRTTLREKNV 125

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE-ITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
            Y N  G F D HT+ +   K GT++ ITT  VVIAVGGRP      G  E  ++SDDIF
Sbjct: 126 TYINAYGKFKDAHTI-VATKKNGTEQIITTDKVVIAVGGRPAYPDAPGAKECCITSDDIF 184

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
             K   PGKTL VGASY++LE AGFL  +G+   V +RSI LRGFDQ++A KI +YM  +
Sbjct: 185 -SKPDAPGKTLCVGASYISLETAGFLTALGFDTSVAIRSIPLRGFDQEVAEKICKYMG-K 242

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            G  F+R + P    K + G++ V +  T  G+ FEETFDTV+ A GRD     L L  A
Sbjct: 243 HGTRFLRDSQPSQFEKQEDGKIKVTFENTMFGNTFEETFDTVVCAVGRDAVTEGLDLPAA 302

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV--Q 355
           GV+ N K G+I   +EQT  PN+YAIGDV+D   ELTPVAI+AG  L RR++ +     +
Sbjct: 303 GVEFNAKNGKIPCVDEQTNVPNIYAIGDVLDTRQELTPVAIKAGVRLMRRVFADTPYKEK 362

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA--- 412
           M+YD + T VFTP+EYG  G+SEE + E YG D+VE Y   F PLEW++  +        
Sbjct: 363 MNYDLVPTTVFTPLEYGTIGMSEELAVETYGADNVECYISYFKPLEWTVNHEEHNGVPVR 422

Query: 413 --ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
              +C+VK++ +   +  V+GFHYLGPNAGEVTQ   +AMK+G T     +TVGIHP
Sbjct: 423 DDNACFVKLITNLADDERVVGFHYLGPNAGEVTQGYAVAMKMGATKRDFDETVGIHP 479


>gb|ADL62852.1| thioredoxin reductase 1 [Haemonchus contortus]
          Length = 625

 Score =  410 bits (1054), Expect = e-112
 Identities = 233/482 (48%), Positives = 310/482 (64%), Gaps = 28/482 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           ++YDL+V+GGGSGGLA +K AA  GKKV VLD+VKPSP G++WGLGGTCVNVGCIPKKLM
Sbjct: 129 HNYDLIVVGGGSGGLAAAKMAALHGKKVAVLDFVKPSPQGSTWGLGGTCVNVGCIPKKLM 188

Query: 62  HQSSLIGEILHHDCASFGWNV--GSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           HQ++++G  +  D   FGW +  G +N      +W+ L + V            V+LR K
Sbjct: 189 HQAAILGHSI-KDAKMFGWKIPEGEIN-----HNWENLRNAVQDHISSLNWGYRVQLREK 242

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDD 177
           QV Y N  G F  P  +   + K   +++T    +IA G RPR    + G  E  V+SDD
Sbjct: 243 QVTYINSYGRFTGPFEISATNKKGEVEKLTADRFLIATGLRPRYPPDVPGVREYCVTSDD 302

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           +F +    PGKTL VGASYV+LECAGFL+G+GY V VMVRSILLRGFDQDMA +I  +M+
Sbjct: 303 LFSLPY-PPGKTLCVGASYVSLECAGFLQGLGYDVTVMVRSILLRGFDQDMAERIRAHMK 361

Query: 238 MQSGIEFIRKTVPQSI------TKLDSGQLLVKWITEDGDC----FEETFDTVLNATGRD 287
            + G++F    VP  I      TK  +G+L V +  +  D       E F+TV+ A GRD
Sbjct: 362 -ECGVKF-ENAVPTRIEEIEPKTKKQAGRLRVFFARKISDTETEEHSEEFNTVVIAIGRD 419

Query: 288 PDVAKLGLDEAGVKLNEKTGRIWVNNEQT-TTPNVYAIGDV-IDAPELTPVAIQAGRLLS 345
                +GLD  GV+     G++    EQ+ T P VYAIGDV  + PELTPVAIQAG++L 
Sbjct: 420 AMTKDIGLDVVGVE-TASNGKVKGRREQSLTCPYVYAIGDVPANTPELTPVAIQAGKVLM 478

Query: 346 RRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLA 405
            RLY    +  +YD++ T VFTP+EYGCCGL+EE++K+ YG+D+V VYH  F+PLE+++A
Sbjct: 479 NRLYYGSDLLTEYDEVPTTVFTPLEYGCCGLTEENAKQRYGEDNVIVYHAVFIPLEYTVA 538

Query: 406 EQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGI 465
           E  R+  + CY K++C  + N  V+GFH L PNAGE+TQ  G+A+KLG T       +GI
Sbjct: 539 E--RMDKDHCYCKLICLASDNERVIGFHILAPNAGEITQGFGIALKLGGTKADFDRLIGI 596

Query: 466 HP 467
           HP
Sbjct: 597 HP 598


>emb|CBN76987.1| Thioredoxin reductase [Ectocarpus siliculosus]
          Length = 773

 Score =  410 bits (1053), Expect = e-112
 Identities = 235/487 (48%), Positives = 290/487 (59%), Gaps = 62/487 (12%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLAC+KEAA  GKKV  LD+VKPS  G+ WGLGGTCVNVGCIPKKLM
Sbjct: 304 YDYDLVVIGGGSGGLACAKEAARLGKKVACLDFVKPSVMGSKWGLGGTCVNVGCIPKKLM 363

Query: 62  HQSSLIGEILHHDCASFGW-------------NVGSVNG----QVPTFDWKQLVSNVXXX 104
           HQ++L+      D   FGW               G V G    +  T DW+ +V  V   
Sbjct: 364 HQAALLAGHA-KDAPFFGWPAGPEGEDGSRLEEAGGVAGGEGKRSVTHDWEVMVQGVQNY 422

Query: 105 XXXXXXXXXVELRSKQVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQL 164
                     +LRSK V+Y N LG   D HT+         + ++   VV+AVGGRP QL
Sbjct: 423 IKGLNFKYRTDLRSKGVEYINALGRLQDAHTVVATDKNNKERVLSCGSVVVAVGGRPNQL 482

Query: 165 ACLGGELAVSSDDIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGF 224
            C GGELA++SDDIF ++   PGKTLVVGASYVALECAGFL G+G    VMVRSILLRGF
Sbjct: 483 PCEGGELAMTSDDIFALR-TPPGKTLVVGASYVALECAGFLTGLGVDTTVMVRSILLRGF 541

Query: 225 DQDMASKIGEYMEMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGD---CFEETFDTVL 281
           DQ +A +IG +ME + G  F+R  VPQ I+K + G+LLV+W   +GD     EE FDTVL
Sbjct: 542 DQGIAERIGSFMEAE-GTRFLRPAVPQRISKTEQGRLLVRWREGEGDDQTTKEEEFDTVL 600

Query: 282 NATGRDPDVAKLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID-APELTPVAIQA 340
            ATGR  D   LGL+  GV L+   G++   NE+TT   V+ IGD ++  PELTP A+QA
Sbjct: 601 AATGRRADTQGLGLERLGVTLS-NNGKMVCRNEETTVAGVFGIGDAVEGVPELTPSAVQA 659

Query: 341 GRLLSRRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPL 400
           GRLL+ RL+                                    G+++VEV+H  F PL
Sbjct: 660 GRLLAMRLFG-----------------------------------GEENVEVFHSAFTPL 684

Query: 401 EWSLAEQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLV 460
           EW +  +      +CYVK VCD T +  V+G H+LGPNAGEV Q  G+ ++LG T D L 
Sbjct: 685 EWQMNSER--PQNACYVKAVCDLTDSQRVVGLHFLGPNAGEVMQGFGVGIRLGMTMDDLR 742

Query: 461 DTVGIHP 467
             VGIHP
Sbjct: 743 QLVGIHP 749


>gb|EFB29376.1| hypothetical protein PANDA_009396 [Ailuropoda melanoleuca]
          Length = 464

 Score =  409 bits (1050), Expect = e-112
 Identities = 226/455 (49%), Positives = 298/455 (65%), Gaps = 24/455 (5%)

Query: 22  AASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQSSLIGEILHHDCASFGWN 81
           AA  GKKV V+DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ++L+G ++  D   +GW 
Sbjct: 1   AAQLGKKVAVVDYVEPSPRGTRWGLGGTCVNVGCIPKKLMHQAALLGGMIR-DAPHYGWA 59

Query: 82  VGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKYENVLGSFVDPHTLKLWHP 141
           V  V       DW+ +   V            V+L+ ++VKY N+  SFV+ HT+     
Sbjct: 60  VQPV-----LHDWRTMAEAVQNYVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTV--CGV 112

Query: 142 KKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIFWMKQKEPGKTLVVGASYV 197
            K  KE  ++  H+VIA GGRP+    + G  E  ++SDDIFW+K+  PGKTLVVGASYV
Sbjct: 113 AKDGKETLLSAEHIVIATGGRPKYPTHIEGALEYGITSDDIFWLKES-PGKTLVVGASYV 171

Query: 198 ALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSGIEFIRKTVPQSITKLD 257
           ALECAGFL G+G    VM+RSI LRGFDQ M+S + EYM  Q G  F+R   P  +  L 
Sbjct: 172 ALECAGFLTGLGLDTTVMIRSIPLRGFDQQMSSLVTEYMASQ-GTRFLRGCTPSRVRGLP 230

Query: 258 SGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLDEAGVKLNEKTGRIWVNNE 314
            GQL V W  ED    +E   TF+TVL A GR P+   L L++AGV  N  + +I V+ +
Sbjct: 231 DGQLQVTW--EDLTSGKEDMGTFNTVLWAIGRIPETRSLNLEKAGVNTNPNSQKILVDAQ 288

Query: 315 QTTT-PNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFTPIEYG 372
           +TT+ P++YAIGD+ +  PELTP AI AG+LL++RL  + +  MDYD + T VFTP+EYG
Sbjct: 289 ETTSVPHIYAIGDIAEGRPELTPTAIMAGKLLAQRLCGQSSDVMDYDNVPTTVFTPLEYG 348

Query: 373 CCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVCDKTRNNFVLGF 432
           C GLSEE++   +G++ VEVYH  + PLE+++AE+    A  CY+K+VC +     VLG 
Sbjct: 349 CVGLSEEEAVARHGEEHVEVYHAYYKPLEFTVAERD---ASQCYIKMVCLRKPPQLVLGL 405

Query: 433 HYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 406 HFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHP 440


>ref|XP_001984837.1| GH16699 [Drosophila grimshawi]
 gb|EDV97185.1| GH16699 [Drosophila grimshawi]
          Length = 514

 Score =  409 bits (1050), Expect = e-112
 Identities = 224/470 (47%), Positives = 304/470 (64%), Gaps = 15/470 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           +DYDLVV+GGGSGGLAC+KEA  +G +V   DYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 30  HDYDLVVLGGGSGGLACAKEAVEYGARVLCFDYVKPTPAGTKWGVGGTCVNVGCIPKKLM 89

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GWN   VN +    +WK+L+ +V            V+LR KQV
Sbjct: 90  HQASLLGEAV-HEAVAYGWN---VNDRDIKPNWKKLIQSVQNHIKSVNWVTRVDLRDKQV 145

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
           +Y N +G+FVD HT++    +   K+++  +VVIAVGGRPR     G  E  ++SDDIF 
Sbjct: 146 EYVNSMGAFVDAHTIEYRTKQGERKQLSAENVVIAVGGRPRYPLIPGAIEFGITSDDIF- 204

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
             + EPG+TLVVGA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M    
Sbjct: 205 SYETEPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TDR 263

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE-TFDTVLNATGRDPDVAKLGLDEAG 299
           GI F+   +P ++ +  +G LLVK++       E   FDTVL A GR      L L  AG
Sbjct: 264 GIPFLNTCIPTAVQRQANGSLLVKYLNTTTQKEESGVFDTVLWAIGRKGLTEDLNLVAAG 323

Query: 300 VK-LNEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMD 357
           VK +N+K      + E T  P++YA+GD+I   PELTPVAI +GRLL+RRL+      MD
Sbjct: 324 VKTVNDKIA--VDHTEATNVPHIYAVGDIIYGRPELTPVAILSGRLLARRLFAGSKQLMD 381

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYV 417
           Y  + T VFTP+EY C G+SEE + E+ G +++EV+H  + P E+ + ++   +   CY+
Sbjct: 382 YTDVATTVFTPLEYSCVGMSEEMAIEKLGAENIEVFHGYYKPTEFFIPQK---SVRYCYL 438

Query: 418 KVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           K V + + +  +LG HY+GP AGEV Q    A+K G T   L++TVGIHP
Sbjct: 439 KAVAEVSGDQKILGLHYMGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHP 488


>gb|ADY41259.1| Thioredoxin reductase 1 [Ascaris suum]
          Length = 685

 Score =  406 bits (1043), Expect = e-111
 Identities = 229/479 (47%), Positives = 307/479 (64%), Gaps = 24/479 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           ++YDLVVIGGGSGGLA +KEAA  GKKV  LD+VKPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 194 HNYDLVVIGGGSGGLAAAKEAARLGKKVLCLDFVKPSVMGTTWGLGGTCVNVGCIPKKLM 253

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+GE +  D   FGW +   + ++   +W+++ + +            V+LR + V
Sbjct: 254 HQAALLGEYI-GDAKKFGWEIPKGDMKL---NWEKMRNAIQDHIASLNWGYRVQLRERSV 309

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G F   H L   + KK  +++T    +IA G RPR     G  E  +SSDD+F 
Sbjct: 310 TYSNAYGVFTGSHELTTTNKKKKVEKVTADRFIIATGLRPRYPDVPGAKECCISSDDLFS 369

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTL VGASYV+LECAGFLKG+G  V VMVRSILLRGFDQDMA +I  +M M  
Sbjct: 370 LTY-NPGKTLCVGASYVSLECAGFLKGIGNDVTVMVRSILLRGFDQDMAERIRRHM-MTH 427

Query: 241 GIEFIRKTVPQSITKLDS------GQLLVKW--ITEDGD---CFEETFDTVLNATGRDPD 289
            I+FI   VP    +++       G + V W   ++DG+   C ++ F+TVL A GRD  
Sbjct: 428 EIKFI-NAVPTKYERIEEPADDKPGLVRVYWEETSQDGEKTPCTQD-FNTVLMAIGRDAV 485

Query: 290 VAKLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRL 348
             ++GL+  GV+   K+G+I    EQ+T P VY IGDV++  PELTPVAIQAGR+L RRL
Sbjct: 486 TDEMGLELVGVE-RTKSGKIVGRREQSTCPYVYGIGDVLNGCPELTPVAIQAGRVLMRRL 544

Query: 349 YNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQT 408
               +   +YD++ T VFTP+EYGCCGL+EE + ++YG +++ VYH  F+PLE+S+ E  
Sbjct: 545 ITGNSELTEYDQVPTTVFTPLEYGCCGLAEEAAIQKYGKENINVYHNVFIPLEYSVPE-- 602

Query: 409 RIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           R+    CY K++C KT  + VLG+H L PNAGE+TQ   + +KL          +GIHP
Sbjct: 603 RVENSHCYCKLICLKTEQDLVLGYHILAPNAGEITQGFAIGLKLKAKKADFDRLIGIHP 661


>ref|XP_001459173.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK91776.1| unnamed protein product [Paramecium tetraurelia]
          Length = 475

 Score =  406 bits (1043), Expect = e-111
 Identities = 224/471 (47%), Positives = 302/471 (64%), Gaps = 18/471 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y YD+ VIGGGSGGL    EA   GK+V + DY+KPSPHGT WG GGTC NVGCIPKKLM
Sbjct: 5   YQYDIFVIGGGSGGLTVVDEAQRLGKRVGLADYIKPSPHGTQWGTGGTCPNVGCIPKKLM 64

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVEL-RSKQ 120
           H ++LIGEI  H+  + GW     + +    DW  LV+ V              L  +  
Sbjct: 65  HMTALIGEI-RHELTATGWQGVDPHSK---NDWNILVNEVQRQVKGINKGNDDWLIATNG 120

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           + Y N LG   D HT++L      ++ +T  ++VIAVG RP     +    +L ++SDD+
Sbjct: 121 ITYYNKLGKLKDDHTIELIDKDGQSEFVTAEYIVIAVGSRPSFPTDIPNVKQLTITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +K K PGKTLVVGASYVALECAGFL G+GY V VMVRSILLRGFDQ+MA +IGE+M++
Sbjct: 181 FSLK-KAPGKTLVVGASYVALECAGFLTGLGYDVTVMVRSILLRGFDQEMAERIGEFMKI 239

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
             G +FIR T+P SI  +D G+ LVKW+  +G    E FDTVL A GR  D   LGL++ 
Sbjct: 240 H-GTKFIRGTIPSSIEDVD-GKRLVKWVL-NGQEQSEVFDTVLLAIGRSADTQNLGLEQV 296

Query: 299 GVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV+ N+++G+I  N+ + T+ PN++AIGD +    ELTP AI  G+ L +RLY+ G   M
Sbjct: 297 GVQTNKESGKIIANDADSTSVPNIFAIGDCVQGRLELTPTAIMCGKRLIKRLYSNGNQIM 356

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           +Y  + T VFTP+EYGC G SEE + +++G D+++++   F PL W+ A +      +CY
Sbjct: 357 EYSDVSTTVFTPLEYGCVGYSEEAAIQKFGKDNLKIFTSEFTPLFWNFANR----KGTCY 412

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            K++  K  ++ V+GFHYLGP+A EVTQ  G+ +KL      L + VGIHP
Sbjct: 413 AKLIVKKD-DDVVIGFHYLGPDAAEVTQGFGVVIKLKAKKSDLDNVVGIHP 462


>ref|XP_002428198.1| thioredoxin reductase, putative [Pediculus humanus corporis]
 gb|EEB15460.1| thioredoxin reductase, putative [Pediculus humanus corporis]
          Length = 490

 Score =  404 bits (1039), Expect = e-110
 Identities = 209/466 (44%), Positives = 302/466 (64%), Gaps = 11/466 (2%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+K+A++ G  VC++DYV PSP G +WG+GGTCVNVGCIPKKLMHQ
Sbjct: 8   FDLIVIGGGSGGLACAKQASTLGASVCLIDYVTPSPKGNTWGMGGTCVNVGCIPKKLMHQ 67

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+GE +  D A++GW +  ++      DW++L   +            V L+  +++Y
Sbjct: 68  AALLGEAI-QDAAAYGWVINDLD--KVKIDWERLKQAIQNHIKSVNWVTRVILKENKIEY 124

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFWMK 182
            N +G F+D +T+++   K  +K I  ++++IAVGGRP+     G  E  +SSDDIF + 
Sbjct: 125 INGIGKFIDKNTIEV-TTKTDSKNIYGKNILIAVGGRPKYPDIPGAVEYGISSDDIFNL- 182

Query: 183 QKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSGI 242
              PGK LVVGA Y+ALECAGFL    + V VMVRS+ LR FDQ MA  I + +    G+
Sbjct: 183 PSAPGKVLVVGAGYIALECAGFLNSFKFPVTVMVRSVTLRNFDQQMAHLIEKNLS-DRGV 241

Query: 243 EFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKL 302
            F+++T+P  I K +    +    +++     E FD VL A GR      L L   GVK+
Sbjct: 242 TFLKETLPVKIEKNNKNLTVTYKNSKNDQIKNENFDNVLFAIGRKTSTEGLNLQAIGVKI 301

Query: 303 NEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDYDKI 361
           ++++G+I   NE+T  PN+YA+GDV+   PELTPVAI+AG+LL++RL+      M+Y+ I
Sbjct: 302 DKESGKIIAENERTNIPNIYAVGDVLHGKPELTPVAIEAGKLLAKRLFGNSNEYMNYENI 361

Query: 362 CTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVC 421
            T +F P+EYGC GLSEE + E++G+ ++EVYH  + P E+ + ++   +A  CY+KVV 
Sbjct: 362 ATTIFCPLEYGCVGLSEEKAIEKFGEANIEVYHTFYKPTEFFIPDK---SAAQCYLKVVT 418

Query: 422 DKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +     VLG H++GP+AGE+ Q    AMK  FT DQL+ TVGIHP
Sbjct: 419 MRNDPKLVLGMHFVGPSAGEIIQGYAAAMKCKFTMDQLIATVGIHP 464


>ref|XP_003056182.1| thioredoxin-disufide reductase [Micromonas pusilla CCMP1545]
 gb|EEH59558.1| thioredoxin-disufide reductase [Micromonas pusilla CCMP1545]
          Length = 497

 Score =  404 bits (1038), Expect = e-110
 Identities = 224/475 (47%), Positives = 291/475 (61%), Gaps = 16/475 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++DYDLVV+GGGSGGLA +KEAA  G KV  LD+VKPSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 7   AFDYDLVVVGGGSGGLATAKEAAKLGAKVACLDFVKPSPAGTSWGLGGTCVNVGCIPKKL 66

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ+ ++GE    D   FGW + S        DW ++V+ +              LR   
Sbjct: 67  MHQAGILGESF-SDAREFGWKLRS-----DGHDWSKMVNGIQDHIGSLNFGYRTALRDNN 120

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  GSF+D HT+          +IT+   VIAVGGRP  L   G  E  ++SDD+F
Sbjct: 121 VTYINAFGSFIDEHTITATKKNGKVDKITSERFVIAVGGRPSYLDVPGARECCITSDDVF 180

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +  K PGKTL VGASY++LE AGFL  +GY   V +RS+ LRGFD ++A  +  +ME +
Sbjct: 181 SL-PKPPGKTLCVGASYISLETAGFLTALGYDTTVAIRSVPLRGFDSEIAEMVVSHME-R 238

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVK-WITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            G  F+R + P +  K   GQ+ V    T  G  F   FDTV+ A GR      L L  A
Sbjct: 239 HGTNFMRDSQPVAFEKAADGQIKVSIKNTVFGSEFAAVFDTVILAVGRMAVTEGLNLATA 298

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV +N K G+I   +E T  P+++AIG V+D   ELTPVAI+AG  L+RRLY+  T +MD
Sbjct: 299 GVHVNPKNGKIPAVDEVTNVPHIFAIGYVLDTRQELTPVAIKAGVRLARRLYSGSTEKMD 358

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA----- 412
           Y  + T VFTP EYGC G+SEE + E YG+++VEVYH  F PLEW++  +          
Sbjct: 359 YSLVPTTVFTPQEYGCIGMSEEQAIEMYGEENVEVYHSYFKPLEWTINHEALDGVAHRED 418

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            SCY K++ + + +  V+GFHY+GP+AGEVTQ   +AM++G        TVGIHP
Sbjct: 419 NSCYSKLITNLSDDERVIGFHYIGPHAGEVTQGYAVAMRMGAKKRDFDGTVGIHP 473


>ref|XP_003093270.1| CRE-TRXR-1 protein [Caenorhabditis remanei]
 gb|EFO94530.1| CRE-TRXR-1 protein [Caenorhabditis remanei]
          Length = 666

 Score =  403 bits (1036), Expect = e-110
 Identities = 222/479 (46%), Positives = 301/479 (62%), Gaps = 23/479 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEAA  GKKV  LD+VKPSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 173 HTYDLIVIGGGSGGLAAAKEAARLGKKVACLDFVKPSPQGTTWGLGGTCVNVGCIPKKLM 232

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+G  + HD   FGW +       P   W  L  +V            V+LR K V
Sbjct: 233 HQASLLGHSI-HDAQKFGWKLEG----KPEHQWSHLRDSVQDHIASLNWGYRVQLREKTV 287

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDIFW 180
            Y N  G F  P  +   + KK  ++IT    +IA G RP+     G  E  ++SDD+F 
Sbjct: 288 TYINSYGEFTGPFEISATNKKKKVEKITADRFLIATGLRPKYPDFPGVKEYTITSDDLFQ 347

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTL VGASYV+LECAGFL G+G+ V VMVRSILLRGFDQDMA +I ++M +  
Sbjct: 348 LPY-SPGKTLCVGASYVSLECAGFLHGLGFDVTVMVRSILLRGFDQDMAERIRKHM-IAY 405

Query: 241 GIEFIRKTVPQSITKLD------SGQLLVKWITEDGDC-----FEETFDTVLNATGRDPD 289
           G++F    VP  I +++      +G+  V W  ++ +      F E ++T+L A GR+  
Sbjct: 406 GLKF-ESGVPTKIEQIEEKTDEKAGKYRVYWPKKNEETGEMQEFSEEYNTILYAIGREAV 464

Query: 290 VAKLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRL 348
              +GL+  GV+  +    +    + TT P VYAIGDV++  PELTPVAIQAGR+L RR+
Sbjct: 465 TDDVGLETIGVERAKSKKVVGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLMRRI 524

Query: 349 YNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQT 408
           +       +YD+I T VFTP+EYGCCGL+EED+ ++YG +++ +YH  F PLE++++E  
Sbjct: 525 FEGANELTEYDQIPTTVFTPLEYGCCGLAEEDAVKKYGKENIIIYHNVFNPLEYTISE-- 582

Query: 409 RIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           R+  + CY+K++C +     V+GFH L PNAGE+TQ  G+A+KL          +GIHP
Sbjct: 583 RMDKDHCYLKLICLRNEEEKVVGFHILTPNAGEITQGFGIALKLSAKKADFDRLIGIHP 641


>ref|XP_001415584.1| thioredoxin reductase, putative selenoenzyme? [Ostreococcus
           lucimarinus CCE9901]
 gb|ABO93876.1| thioredoxin reductase, putative selenoenzyme [Ostreococcus
           lucimarinus CCE9901]
          Length = 503

 Score =  403 bits (1035), Expect = e-110
 Identities = 229/476 (48%), Positives = 294/476 (61%), Gaps = 18/476 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           ++YD+VVIGGGSGGLA +KEAA  G K   LD+VKPSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 12  HEYDVVVIGGGSGGLAAAKEAAKHGAKTMCLDFVKPSPAGTTWGLGGTCVNVGCIPKKLM 71

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+ ++GE    D   +GW + S        DW ++V  +              LR K V
Sbjct: 72  HQAGILGESF-SDAREYGWKLASEG-----HDWGKMVEQIQNHIGSLNFGYRTTLREKNV 125

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIFW 180
            Y N  G F D +T+         + ITT  VV+AVGGRP      G  E  ++SDDIF 
Sbjct: 126 TYVNAYGRFKDKNTIIATKKNGQEQVITTDKVVVAVGGRPSYPDAPGAKECCITSDDIF- 184

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
            K + PGKTL VGASY++LE AGFL  +G+   V +RSI LRGFDQ++A KI +YM  + 
Sbjct: 185 SKPEAPGKTLCVGASYISLETAGFLTALGFDTAVAIRSIPLRGFDQEVAEKIVKYMG-EH 243

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKW-ITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAG 299
           G  F+R + P    K + G++ V +  T  G+ FEETFDTV+ A GRD     L L  AG
Sbjct: 244 GTRFLRDSQPTVFEKQEDGKIKVTFENTMFGNTFEETFDTVVCAVGRDAVTEGLDLPAAG 303

Query: 300 VKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV--QM 356
           V+ N K G+I   +EQT   N+YAIGDV+D   ELTPVAI+AG  L RR++ +     +M
Sbjct: 304 VEFNPKNGKIACVDEQTNVDNIYAIGDVLDTRQELTPVAIKAGVRLMRRVFADTPYKEKM 363

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA---- 412
           +YD + T VFTP+EYG  G+SEE + E YG D+VE Y   F PLEW+L  +         
Sbjct: 364 NYDLVPTTVFTPLEYGTIGMSEELAVETYGADNVECYVSYFKPLEWTLNHEEHKGVPVRG 423

Query: 413 -ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
             +CYVK++ +   +  V+GFHYLGPNAGEVTQ   +AMK+G T     +TVGIHP
Sbjct: 424 DNACYVKLITNLADDERVVGFHYLGPNAGEVTQGYAVAMKMGATKKDFDETVGIHP 479


>ref|NP_001166984.1| thioredoxin reductase 3 isoform 2 [Homo sapiens]
          Length = 607

 Score =  400 bits (1029), Expect = e-109
 Identities = 230/475 (48%), Positives = 294/475 (61%), Gaps = 55/475 (11%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYDL++IGGGSGGL+C+KEAA  GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 154 AYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKL 213

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW     N QV   +W+ +   +            + LR K 
Sbjct: 214 MHQAALLGQAL-CDSRKFGW---EYNQQV-RHNWETMTKAIQNHISSLNWGYRLSLREKA 268

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FV+ H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 269 VAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERPRYLGIQGDKEYCITSDDLF 328

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G G  V VMVRSILLRGFDQ+MA K+G YME Q
Sbjct: 329 SLPYC-PGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILLRGFDQEMAEKVGSYME-Q 386

Query: 240 SGIEFIRKTVPQSITKLDSG-----QLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLG 294
            G++F+RK +P  + +L+ G     ++L K  TE  +  E  ++TVL A GRD    K+G
Sbjct: 387 HGVKFLRKFIPVMVQQLEKGSPGKLKVLAK-STEGTETIEGVYNTVLLAIGRDSCTRKIG 445

Query: 295 LDEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEG 352
           L++ GVK+NEK+G+I VN+ EQT  P VYA+GD++ D PELTPVAIQ+G+LL++RL    
Sbjct: 446 LEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPVAIQSGKLLAQRL---- 501

Query: 353 TVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAA 412
                                           +G    ++YH  F PLEW++A +     
Sbjct: 502 --------------------------------FGASLEKIYHTLFWPLEWTVAGREN--- 526

Query: 413 ESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +CY K++C+K  ++ V+GFH LGPNAGEVTQ    AMK G T   L DT+GIHP
Sbjct: 527 NTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLLDDTIGIHP 581


>ref|XP_001427531.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK60133.1| unnamed protein product [Paramecium tetraurelia]
          Length = 486

 Score =  400 bits (1027), Expect = e-109
 Identities = 221/469 (47%), Positives = 299/469 (63%), Gaps = 15/469 (3%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           ++D  VIGGGSGGLA +K+AAS G KV + D+VKPSP GT WGLGGTCVNVGCIPKKLMH
Sbjct: 6   EFDFFVIGGGSGGLAAAKQAASQGAKVGLADFVKPSPLGTKWGLGGTCVNVGCIPKKLMH 65

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
            ++L GE L  D    GW    + G+    DW ++  NV             +L +K+VK
Sbjct: 66  FAALAGE-LRKDQVEAGWINADIKGK---HDWNRMTENVRSHIKKLNFQYKNQLNNKEVK 121

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG--GELAVSSDDIFW 180
           Y N L      + +KL     G + + ++ ++IAVGGRP     +    +  ++SDD+FW
Sbjct: 122 YYNKLAELEKSNIVKLIDKDGGVEFVKSKFILIAVGGRPSYPEDIPEIEKKVITSDDLFW 181

Query: 181 MKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQS 240
           +    PGKTLVVGASYVALEC GFL G+G    +MVRSILLRGFDQ++A KI +YM ++S
Sbjct: 182 L-PNNPGKTLVVGASYVALECGGFLNGLGCDSSIMVRSILLRGFDQEIAGKIEDYM-VES 239

Query: 241 GIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGV 300
           GI+FI++ +P +I  ++  + LV W  + G    +TFDTVL ATGR  D +KL L+  GV
Sbjct: 240 GIKFIKEAIPINIEVIEHNRRLVTW-KQKGVQHSDTFDTVLIATGRKSDTSKLNLERVGV 298

Query: 301 KLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDYD 359
           K N+    I   +++T+  N+YAIGD ++  PELTP AI+ G+LL+ RL+      M Y 
Sbjct: 299 KTNKNGKIICTIDDRTSVANIYAIGDCVEGRPELTPTAIKCGQLLANRLFGGQKKMMCYQ 358

Query: 360 KICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVK- 418
            I T VFTP+EYGC G SEE++  ++  + + +YH  F PLEW+L E     A++C +K 
Sbjct: 359 FIPTTVFTPLEYGCIGYSEEEAINKFTQNEIIIYHSIFKPLEWNLLESH--YAQACMIKL 416

Query: 419 VVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           +V   TR   V+G HYLGPNAGEV Q   +A+KLG T +Q   T+GIHP
Sbjct: 417 IVMVSTRR--VIGLHYLGPNAGEVVQGYAVAIKLGATKEQFDATIGIHP 463


>ref|XP_969619.1| PREDICTED: similar to thioredoxin reductase [Tribolium castaneum]
 gb|EFA02207.1| hypothetical protein TcasGA2_TC007865 [Tribolium castaneum]
          Length = 524

 Score =  399 bits (1026), Expect = e-109
 Identities = 212/466 (45%), Positives = 293/466 (62%), Gaps = 10/466 (2%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           ++DL+VIGGGSGGLA +KEAA  G KV V D++ PS     WGL GTC+N+  IPKKLMH
Sbjct: 42  EFDLIVIGGGSGGLAAAKEAAELGAKVAVFDFIVPSARSLKWGLEGTCINIESIPKKLMH 101

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           + +++GE +  D  S+G+    +       +WK L   V            +ELR K+V+
Sbjct: 102 RVAILGEAVQ-DARSYGFQFPKMESL--KHNWKGLRETVQNHIKSINWVTKIELRDKRVE 158

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGELAVSSDDIFWMK 182
           Y N +G F DP+T++    K   K    ++ +I+VGGRP+     G EL +SSD++F + 
Sbjct: 159 YINSMGVFHDPYTIEA-KIKNEWKTFKAKYFLISVGGRPKYPDIPGAELGISSDEVFGL- 216

Query: 183 QKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSGI 242
           +  PGKTL++GA YV +ECAGFLKG+GY + VMVRS++LR FDQ MA  + E M +  G+
Sbjct: 217 ENAPGKTLIIGAGYVGVECAGFLKGLGYDITVMVRSVVLRAFDQQMAKLVTESM-VAKGV 275

Query: 243 EFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKL 302
            F+ K VP SI + +   LLVKWI E  +   + F TVL A GR+  +  L LD+AGV +
Sbjct: 276 RFLHKCVPTSIERSNGKMLLVKWIDETREEGCDEFQTVLFAIGREACIRALRLDKAGVSV 335

Query: 303 NEKTGRIWVNNEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGTVQMDYDKI 361
                +I   NEQT  P++YA+GDV+   P+LT VAI AG+LL+RRL+ + TV MDYD I
Sbjct: 336 VADGDKIETINEQTNVPHIYAVGDVLYKKPDLTQVAIHAGKLLARRLFAKSTVLMDYDNI 395

Query: 362 CTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVC 421
            T +FTP+EYG  GL EE + E YG+D++E+YH  + P E+ + ++T      CY+KVV 
Sbjct: 396 ATTIFTPLEYGSVGLCEETAIERYGEDNIEIYHAYYKPTEFFIPQKTN---AHCYLKVVA 452

Query: 422 DKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            +     VLG H++GP AGEV Q    A+K   T D L +TVGIHP
Sbjct: 453 KRGNQQKVLGMHFVGPQAGEVIQGFSAAIKCNLTVDNLRNTVGIHP 498


>gb|AAD46625.1| thioredoxin reductase homolog [Caenorhabditis elegans]
          Length = 525

 Score =  399 bits (1026), Expect = e-109
 Identities = 228/482 (47%), Positives = 305/482 (63%), Gaps = 28/482 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEA+  GKKV  LD+VKPSP GTSWGLGGTCVNVGCIPKKLM
Sbjct: 29  HTYDLIVIGGGSGGLAAAKEASRLGKKVACLDFVKPSPQGTSWGLGGTCVNVGCIPKKLM 88

Query: 62  HQSSLIGEILHHDCASFGWNV--GSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           HQ+SL+G  + HD   +GW +  G V  Q     W  L  +V            V+LR K
Sbjct: 89  HQASLLGHSI-HDAKKYGWKLPEGKVEHQ-----WNHLRDSVQDHIASLNWGYRVQLREK 142

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDI 178
            V Y N  G F  P  +   + KK  +++T    +I+ G RP+     G  E  ++SDD+
Sbjct: 143 TVTYINSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYPEIPGVKEYTITSDDL 202

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +    PGKTL VGASYV+LECAGFL G G+ V VMVRSILLRGFDQDMA +I ++M +
Sbjct: 203 FQLPY-SPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHM-I 260

Query: 239 QSGIEFIRKTVPQSITKLD------SGQLLVKWITEDGDCFE-----ETFDTVLNATGRD 287
             G++F    VP  I ++D      +G+  V W  ++ +  E     E ++T+L A GR+
Sbjct: 261 AYGMKF-EAGVPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGRE 319

Query: 288 PDVAKLGLDEAGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVID-APELTPVAIQAGRLLS 345
                +GL   GV+   K+ ++    EQ+TT P VYAIGDV++  PELTPVAIQAGR+L 
Sbjct: 320 AVTDDVGLTTIGVE-RAKSKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLM 378

Query: 346 RRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLA 405
           RR+++      +YD+I T VFTP+EYGCCGLSEED+  +YG D++ +YH  F PLE++++
Sbjct: 379 RRIFDGANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTIS 438

Query: 406 EQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGI 465
           E  R+  + CY+K++C +     V+GFH L PNAGEVTQ  G+A+KL          +GI
Sbjct: 439 E--RMDKDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGI 496

Query: 466 HP 467
           HP
Sbjct: 497 HP 498


>ref|NP_501085.2| ThioRedoXin Reductase family member (trxr-1) [Caenorhabditis
           elegans]
 sp|Q17745|TRXR1_CAEEL RecName: Full=Thioredoxin reductase 1; Short=TR-Se; Short=TRR
 gb|AAD41826.1|AF148217_1 thioredoxin reductase [Caenorhabditis elegans]
 gb|AAB03136.3| Thioredoxin reductase protein 1, confirmed by transcript evidence
           [Caenorhabditis elegans]
          Length = 667

 Score =  399 bits (1026), Expect = e-109
 Identities = 228/482 (47%), Positives = 305/482 (63%), Gaps = 28/482 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEA+  GKKV  LD+VKPSP GTSWGLGGTCVNVGCIPKKLM
Sbjct: 171 HTYDLIVIGGGSGGLAAAKEASRLGKKVACLDFVKPSPQGTSWGLGGTCVNVGCIPKKLM 230

Query: 62  HQSSLIGEILHHDCASFGWNV--GSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           HQ+SL+G  + HD   +GW +  G V  Q     W  L  +V            V+LR K
Sbjct: 231 HQASLLGHSI-HDAKKYGWKLPEGKVEHQ-----WNHLRDSVQDHIASLNWGYRVQLREK 284

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDI 178
            V Y N  G F  P  +   + KK  +++T    +I+ G RP+     G  E  ++SDD+
Sbjct: 285 TVTYINSYGEFTGPFEISATNKKKKVEKLTADRFLISTGLRPKYPEIPGVKEYTITSDDL 344

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +    PGKTL VGASYV+LECAGFL G G+ V VMVRSILLRGFDQDMA +I ++M +
Sbjct: 345 FQLPY-SPGKTLCVGASYVSLECAGFLHGFGFDVTVMVRSILLRGFDQDMAERIRKHM-I 402

Query: 239 QSGIEFIRKTVPQSITKLD------SGQLLVKWITEDGDCFE-----ETFDTVLNATGRD 287
             G++F    VP  I ++D      +G+  V W  ++ +  E     E ++T+L A GR+
Sbjct: 403 AYGMKF-EAGVPTRIEQIDEKTDEKAGKYRVFWPKKNEETGEMQEVSEEYNTILMAIGRE 461

Query: 288 PDVAKLGLDEAGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVID-APELTPVAIQAGRLLS 345
                +GL   GV+   K+ ++    EQ+TT P VYAIGDV++  PELTPVAIQAGR+L 
Sbjct: 462 AVTDDVGLTTIGVE-RAKSKKVLGRREQSTTIPWVYAIGDVLEGTPELTPVAIQAGRVLM 520

Query: 346 RRLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLA 405
           RR+++      +YD+I T VFTP+EYGCCGLSEED+  +YG D++ +YH  F PLE++++
Sbjct: 521 RRIFDGANELTEYDQIPTTVFTPLEYGCCGLSEEDAMMKYGKDNIIIYHNVFNPLEYTIS 580

Query: 406 EQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGI 465
           E  R+  + CY+K++C +     V+GFH L PNAGEVTQ  G+A+KL          +GI
Sbjct: 581 E--RMDKDHCYLKMICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGI 638

Query: 466 HP 467
           HP
Sbjct: 639 HP 640


>ref|XP_002633065.1| C. briggsae CBR-TRXR-1 protein [Caenorhabditis briggsae]
 emb|CAP26568.1| CBR-TRXR-1 protein [Caenorhabditis briggsae AF16]
          Length = 667

 Score =  399 bits (1026), Expect = e-109
 Identities = 224/481 (46%), Positives = 304/481 (63%), Gaps = 26/481 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YDL+VIGGGSGGLA +KEAA  GKKV  LD+VKPSP GT+WGLGGTCVNVGCIPKKLM
Sbjct: 173 HTYDLIVIGGGSGGLAAAKEAARLGKKVACLDFVKPSPQGTTWGLGGTCVNVGCIPKKLM 232

Query: 62  HQSSLIGEILHHDCASFGWNV--GSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           HQ+SL+G  + HD   FGW +  G +  Q     W  +  +V            V+LR K
Sbjct: 233 HQASLLGHSI-HDAKKFGWKLPEGKIEHQ-----WGHMRDSVQDHIASLNWGYRVQLREK 286

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLG-GELAVSSDDI 178
            V Y N  G F  P  +   + KK  +++T    +IA G RP+     G  E  ++SDD+
Sbjct: 287 TVTYINSYGEFTGPFEISATNKKKKVEKLTADRFLIATGLRPKYPDYPGVKEYTITSDDL 346

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +    PGKTL VGASYV+LECAGFL G+G+ V VMVRSILLRGFDQDMA +I ++M +
Sbjct: 347 FQLPY-SPGKTLCVGASYVSLECAGFLHGLGFDVTVMVRSILLRGFDQDMAERIRKHM-I 404

Query: 239 QSGIEFIRKTVPQSITKLD------SGQLLVKWITEDGDCFEET-----FDTVLNATGRD 287
             GI+F    VP  I +++      +G+  V W  ++ +  EET     ++T+L A GR+
Sbjct: 405 AYGIKF-ESGVPTRIEQIEEKTDEKAGRYRVFWPKKNEETGEETEVSEEYNTILYAIGRE 463

Query: 288 PDVAKLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID-APELTPVAIQAGRLLSR 346
               ++GLD  GV+  +    +    + TT P VYAIGDV++  PELTPVAIQAGR+L R
Sbjct: 464 AVTDEVGLDSIGVERAKSKKVVGRREQATTIPWVYAIGDVLEGTPELTPVAIQAGRVLMR 523

Query: 347 RLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAE 406
           R++       +Y++I T VFTP+EYGCCGL+EED+ ++YG +++ +YH  F PLE+++ E
Sbjct: 524 RIFEGVNELTEYEQIPTTVFTPLEYGCCGLAEEDAIKKYGKENIIIYHNVFNPLEYTIPE 583

Query: 407 QTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
             R+  + CY+K++C +     V+GFH L PNAGEVTQ  G+A+KL          +GIH
Sbjct: 584 --RMDKDHCYLKLICLRNEEEKVVGFHILTPNAGEVTQGFGIALKLAAKKADFDRLIGIH 641

Query: 467 P 467
           P
Sbjct: 642 P 642


>ref|XP_001452173.1| hypothetical protein [Paramecium tetraurelia strain d4-2]
 emb|CAK84776.1| unnamed protein product [Paramecium tetraurelia]
          Length = 475

 Score =  396 bits (1017), Expect = e-108
 Identities = 218/471 (46%), Positives = 300/471 (63%), Gaps = 18/471 (3%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YD+ VIGGGSGGL    EA   GK+V + DY+KPSPHGT WG GGTC NVGCIPKKLM
Sbjct: 5   FQYDIFVIGGGSGGLTVVDEAQKLGKRVGLADYIKPSPHGTQWGTGGTCPNVGCIPKKLM 64

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVEL-RSKQ 120
           H ++LIGEI  H+  + GW     + +    +W  LV+ V              L  +  
Sbjct: 65  HMTALIGEI-RHELTATGWQGVDPHSK---HNWNTLVNEVQRQVKGINKGNDDWLVTTNG 120

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           + Y N LG   D HT++L      ++ +T  ++VIAVG RP     +    +L ++SDD+
Sbjct: 121 ITYYNKLGKLKDDHTIELIDKDGQSEFVTAEYIVIAVGSRPSFPTDIPNVKQLTITSDDL 180

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +K   PGKTLVVGASYVALECAGFL G+GY V VMVRSILLRGFDQ++A +IGE+M++
Sbjct: 181 FSLK-NAPGKTLVVGASYVALECAGFLTGLGYDVTVMVRSILLRGFDQEIAERIGEFMKI 239

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            SG +FIR T+P SI  +D G+ LVKW+  +G    + FDTVL A GR  D   LGL++ 
Sbjct: 240 -SGTKFIRGTIPSSIEDVD-GKRLVKWVL-NGQEQTDVFDTVLLAIGRSADTQNLGLEQV 296

Query: 299 GVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGTVQM 356
           GV+ N+++G+I  N+ + T+  N++AIGD +    ELTP AI  G+ L +RLY  G   M
Sbjct: 297 GVETNKESGKIIANDADSTSVSNIFAIGDCVQGRLELTPTAIMCGKRLIKRLYQNGNQIM 356

Query: 357 DYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCY 416
           +Y  + T VFTP+EYGC G SEE + +++G ++++++   F PL W+ A +      +CY
Sbjct: 357 EYSDVSTTVFTPLEYGCVGYSEEAATKKFGKENLKIFTSEFTPLFWNFANR----KGTCY 412

Query: 417 VKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            K++  K  ++ V+GFHYLGP+A EVTQ  G+ +KL      L + VGIHP
Sbjct: 413 SKLIV-KKEDDVVIGFHYLGPDAAEVTQGFGVVIKLKAKKSDLDNVVGIHP 462


>gb|EAX03015.1| hCG17888, isoform CRA_c [Homo sapiens]
          Length = 463

 Score =  395 bits (1016), Expect = e-108
 Identities = 224/458 (48%), Positives = 291/458 (63%), Gaps = 42/458 (9%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 80  QAALLGGLIQ-DAPNYGWEVA----QPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 134

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT+      KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 135 YFNIKASFVDEHTV--CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 192

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 193 FWLKES-PGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 251

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 252 H-GTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 308

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 309 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 368

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 369 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 425

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMK 451
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K
Sbjct: 426 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIK 463


>ref|XP_001898729.1| Thioredoxin reductase [Brugia malayi]
 gb|EDP31537.1| Thioredoxin reductase, putative [Brugia malayi]
          Length = 636

 Score =  394 bits (1012), Expect = e-107
 Identities = 226/480 (47%), Positives = 301/480 (62%), Gaps = 26/480 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           ++YDL ++GGGSGGLA +KEA   GKKV  LD+VKPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 145 HEYDLAIVGGGSGGLAAAKEAVRLGKKVVCLDFVKPSAMGTTWGLGGTCVNVGCIPKKLM 204

Query: 62  HQSSLIGEILHHDCASFGWNV--GSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           HQ++L+GE +  D   FGW +  G++       +W QL + V            V+L+ K
Sbjct: 205 HQAALLGEYI-EDAKKFGWEIPEGAIK-----LNWHQLKNAVQNHIASLNWGYRVQLKEK 258

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
            V Y N   +F   H L + + K   +++T    +IAVG RPR     G  E  +SSDD+
Sbjct: 259 SVTYMNSYATFTGSHELSVKNKKGKVEKVTADRFLIAVGLRPRFPDVPGALECCISSDDL 318

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +    PGKTL VGASYV+LECAGFLKG+G  V VMVRS+LLRGFDQDMA +I ++M  
Sbjct: 319 FSLPY-NPGKTLCVGASYVSLECAGFLKGIGNDVTVMVRSVLLRGFDQDMAERIKKHM-T 376

Query: 239 QSGIEFIRKTVPQSITKL------DSGQLLVKWITEDGDCFEET---FDTVLNATGRDPD 289
           + G++F+ + VP    +L      + G + V  + ED D  +E    F+TVL A GRD  
Sbjct: 377 ERGVKFV-QCVPIKYERLKKPTDSEPGMIRVHTMQEDEDGTKEVTEDFNTVLMAIGRDAM 435

Query: 290 VAKLGLDEAGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSRR 347
              LGLD  GV    K+G+I    EQ+ + P VYAIGDV+  +PELTPVAIQAG++L RR
Sbjct: 436 TDDLGLDVVGVN-RAKSGKIIGRREQSVSCPYVYAIGDVLYGSPELTPVAIQAGKVLMRR 494

Query: 348 LYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQ 407
           L+   +   +YDKI T VFTP+EYG CGLSE  + ++YG +++ VYH  F+PLE+++ E 
Sbjct: 495 LFTGSSELTEYDKIPTTVFTPLEYGSCGLSEYSAIQKYGKENINVYHNVFIPLEYAVTE- 553

Query: 408 TRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            R     CY K++C K   + +LGFH L PNAGE+TQ   +A+K           +GIHP
Sbjct: 554 -RKEKTHCYCKLICLKNEQDLILGFHILTPNAGEITQGFAIALKFDAKKADFDRLIGIHP 612


>ref|XP_001166546.1| PREDICTED: thioredoxin reductase 2 isoform 2 [Pan troglodytes]
          Length = 463

 Score =  394 bits (1012), Expect = e-107
 Identities = 223/458 (48%), Positives = 291/458 (63%), Gaps = 42/458 (9%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 80  QAALLGGLIQ-DAPNYGWEVA----QPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 134

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SFVD HT+      KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 135 YFNIKASFVDEHTV--CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 192

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PGKTLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 193 FWLKES-PGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 251

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 252 H-GTRFLRGCAPSRVRRLPDGQLQVTW--EDCTTGKEDTGTFDTVLWAIGRVPDTRSLNL 308

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YA+GDV++  PELTP AI AGRLL +RL+   +
Sbjct: 309 EKAGVDTSPDTQKILVDSREATSVPHIYAVGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 368

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 369 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVAHHGQEHVEVYHAHYKPLEFTVAGRD---AS 425

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMK 451
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K
Sbjct: 426 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIK 463


>gb|EDK97526.1| thioredoxin reductase 2, isoform CRA_c [Mus musculus]
          Length = 498

 Score =  393 bits (1010), Expect = e-107
 Identities = 226/473 (47%), Positives = 294/473 (62%), Gaps = 54/473 (11%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 47  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 106

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 107 AALLGGMIR-DAHHYGWEVA----QPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 161

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 162 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 219

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 220 WLKES-PGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESH 278

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 279 -GTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 335

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 336 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 395

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY                                 VYH  + PLE+++A++    A  
Sbjct: 396 LMDYSN-------------------------------VYHAYYKPLEFTVADRD---ASQ 421

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 422 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 474


>gb|AAQ03230.1|AF412308_1 mitochondrial thioredoxin reductase 2 [Mus musculus]
          Length = 496

 Score =  393 bits (1010), Expect = e-107
 Identities = 226/473 (47%), Positives = 294/473 (62%), Gaps = 54/473 (11%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQ 63
           +DL+VIGGGSGGLAC+KEAA  GKKV V DYV+PSP GT WGLGGTCVNVGCIPKKLMHQ
Sbjct: 43  FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 102

Query: 64  SSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKY 123
           ++L+G ++  D   +GW V     Q    +WK +   V            V+L+ ++VKY
Sbjct: 103 AALLGGMIR-DAHHYGWEVA----QPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKY 157

Query: 124 ENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDDIF 179
            N+  SFVD HT++     KG K   ++  H+VIA GGRPR    + G  E  ++SDDIF
Sbjct: 158 FNIKASFVDEHTVR--GVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIF 215

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
           W+K+  PGKTLVVGASYVALECAGFL G+G    VM+RSI LRGFDQ M+S + E+ME  
Sbjct: 216 WLKES-PGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESH 274

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGLD 296
            G +F++  VP  I KL + QL V W  ED    +E   TFDTVL A GR P+   L L+
Sbjct: 275 -GTQFLKGCVPSHIKKLPTNQLQVTW--EDHASGKEDTGTFDTVLWAIGRVPETRTLNLE 331

Query: 297 EAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTV 354
           +AG+  N K  +I V+  E T+ P++YAIGDV +  PELTP AI+AG+LL++RL+ + + 
Sbjct: 332 KAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSST 391

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAES 414
            MDY                                 VYH  + PLE+++A++    A  
Sbjct: 392 LMDYSN-------------------------------VYHAYYKPLEFTVADRD---ASQ 417

Query: 415 CYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           CY+K+VC +     VLG H+LGPNAGEVTQ   L +K G +Y Q++ TVGIHP
Sbjct: 418 CYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHP 470


>ref|XP_002258509.1| thioredoxin reductase 2 [Plasmodium knowlesi strain H]
 emb|CAQ39281.1| thioredoxin reductase 2, putative [Plasmodium knowlesi strain H]
          Length = 623

 Score =  392 bits (1007), Expect = e-107
 Identities = 220/484 (45%), Positives = 300/484 (61%), Gaps = 28/484 (5%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYD VVIGGG GG+A +KEAAS G KV + DYVKPS  GT WG+GGTCVNVGC+PKKL
Sbjct: 120 NYDYDYVVIGGGPGGMASAKEAASHGAKVLLFDYVKPSNKGTKWGIGGTCVNVGCVPKKL 179

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH +  +G +   D   +GW+  ++       +W +LV+ V              LRS +
Sbjct: 180 MHYAGNMGSLFKMDSNPYGWSYNNL-----IHNWGKLVTTVQSHIRSLNFSYMTGLRSSK 234

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSD 176
           VKY N L S  D HT+  +     +KE  +T ++++IA G RP     + G  EL+++SD
Sbjct: 235 VKYMNGLASLKDEHTVSYYLKGDMSKEELVTAKYILIATGCRPSIPDDVEGAKELSITSD 294

Query: 177 DIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYM 236
           DIF MK K+PGKTL+VGASYVALECAGFL  +GY V V VRSI+LRGFD   A K+  YM
Sbjct: 295 DIFSMK-KDPGKTLIVGASYVALECAGFLNSLGYDVTVAVRSIVLRGFDSQCALKVKIYM 353

Query: 237 EMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           E Q G+ F    +P+ ++K++  ++ V +     D   E FDTVL ATGR  D+  L LD
Sbjct: 354 EEQ-GVLFKHGVLPKKLSKMEGEKISVLF----NDGTTELFDTVLYATGRKGDIDMLNLD 408

Query: 297 EAGVKLNEKTGRIWVNNEQ-TTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNEGTV 354
           +  +++N+ T +I  N    T   N++A+GDV +D PEL PVAI+AG +L+RRL+N+   
Sbjct: 409 QVKIQVNKNTNKIITNEVSCTNISNIFAVGDVAVDVPELAPVAIKAGEILARRLFNQSEE 468

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR----- 409
            MDY  I T+++TPIEYG CG SEE + E +G  +VEV+ + F  LE S   + +     
Sbjct: 469 IMDYTFIPTSIYTPIEYGTCGYSEEKAYEIFGTSNVEVFLQEFNNLEISAVHREKHVRAQ 528

Query: 410 ------IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTV 463
                   + +C  K+VC K  +N V+GFHY+GPNAGE+TQ M LA++L          +
Sbjct: 529 KDQYDTDVSSTCLSKLVCLKNEDNRVVGFHYVGPNAGEITQGMALALRLKAKKSDFDKCI 588

Query: 464 GIHP 467
           GIHP
Sbjct: 589 GIHP 592


>dbj|BAG53517.1| unnamed protein product [Homo sapiens]
          Length = 463

 Score =  391 bits (1005), Expect = e-106
 Identities = 222/458 (48%), Positives = 290/458 (63%), Gaps = 42/458 (9%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           DYDL+V+GGGSGGLAC+KE                   GT WGLGGTCVNVGCIPKKLMH
Sbjct: 39  DYDLLVVGGGSGGLACAKE-------------------GTRWGLGGTCVNVGCIPKKLMH 79

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
           Q++L+G ++  D  ++GW V     Q    DW+++   V            V+L+ ++VK
Sbjct: 80  QAALLGGLIQ-DAPNYGWEVA----QPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVK 134

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEI--TTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           Y N+  SF D HT+      KG KEI  +  H++IA GGRPR    + G  E  ++SDDI
Sbjct: 135 YFNIKASFGDEHTV--CGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDI 192

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           FW+K+  PG+TLVVGASYVALECAGFL G+G    +M+RSI LRGFDQ M+S + E+M  
Sbjct: 193 FWLKES-PGETLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS 251

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEE---TFDTVLNATGRDPDVAKLGL 295
             G  F+R   P  + +L  GQL V W  ED    +E   TFDTVL A GR PD   L L
Sbjct: 252 H-GTRFLRGCAPSRVRRLPDGQLQVTW--EDSTTGKEDTGTFDTVLWAIGRVPDTRSLNL 308

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGT 353
           ++AGV  +  T +I V++ E T+ P++YAIGDV++  PELTP AI AGRLL +RL+   +
Sbjct: 309 EKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSS 368

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDYD + T VFTP+EYGC GLSEE++   +G + VEVYH ++ PLE+++A +    A 
Sbjct: 369 DLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRD---AS 425

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMK 451
            CYVK+VC +     VLG H+LGPNAGEVTQ   L +K
Sbjct: 426 QCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALGIK 463


>ref|XP_002085912.1| GD15034 [Drosophila simulans]
 gb|EDX11497.1| GD15034 [Drosophila simulans]
          Length = 516

 Score =  388 bits (997), Expect = e-106
 Identities = 217/474 (45%), Positives = 305/474 (64%), Gaps = 22/474 (4%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           Y+YDLVV+GGG GG+   +  A  G +V   DYVKP+P GT WG+GGTCVNVGCIPKKLM
Sbjct: 31  YNYDLVVLGGGLGGIGVRQGGAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLM 90

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ+SL+GE + H+  ++GWNV   N +    DW +LV +V             +L  K+V
Sbjct: 91  HQASLLGEAV-HEAVAYGWNVDDKNIRP---DWGKLVRSVQNHIKSVKWVTRQDLGDKKV 146

Query: 122 KYENVLGSFVDPHTLK-LWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           +Y N +GSF D HT++ +  P    +++T+ +VV+AVGGRPR     G  EL ++SDDIF
Sbjct: 147 EYVNSMGSFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIF 206

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
              ++EPG+TLV GA YV LECA FLKG+GY   VMVRSI+LRGFD+ M+  +   M  +
Sbjct: 207 -SYEREPGRTLVKGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMM-TE 264

Query: 240 SGIEFIRKTVPQSITKLDSGQLLVKW----ITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            GI F+  T+P+++ +   G+LLV++       DG    + FDTVL A GR   +  L L
Sbjct: 265 RGIPFLGTTIPKAVERQADGRLLVRYRNTSTQMDG---SDVFDTVLWAIGRKGLIEDLNL 321

Query: 296 DEAGVKLNEKTGRIWVN-NEQTTTPNVYAIGDVI-DAPELTPVAIQAGRLLSRRLYNEGT 353
           + AGVK ++   +I V+  E T+ P+++A+GD+I   PELTPVAI +GRLL+RRL+   T
Sbjct: 322 EAAGVKTHD--DKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGST 379

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE 413
             MDY  + T VFTP+EY C G+SEE + E  G D++EV+H  + P E+ + ++   +  
Sbjct: 380 QLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQK---SVR 436

Query: 414 SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
            CY+K V + + +  +LG HY+GP AGEV Q    A+K G T   +++TVGIHP
Sbjct: 437 HCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTVLNTVGIHP 490


>ref|XP_001614770.1| thioredoxin reductase 2 [Plasmodium vivax SaI-1]
 gb|EDL45043.1| thioredoxin reductase 2, putative [Plasmodium vivax]
          Length = 546

 Score =  387 bits (994), Expect = e-105
 Identities = 220/483 (45%), Positives = 295/483 (61%), Gaps = 28/483 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYD VVIGGG GG+A +KEAA+ G KV + DYVKPS  GT WG+GGTCVNVGC+PKKLM
Sbjct: 44  YDYDYVVIGGGPGGMASAKEAAAHGAKVLLFDYVKPSSKGTKWGIGGTCVNVGCVPKKLM 103

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           H +  +G +   D   +GW    +     + +W +LVS V              LRS QV
Sbjct: 104 HYAGNMGSLFKLDSTQYGWTCKDL-----SHNWGKLVSTVQSHIRSLNFSYLTGLRSSQV 158

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDD 177
           KY N L S  D HT+  +     ++E  IT ++++IA G RP     + G  EL+++SDD
Sbjct: 159 KYINGLASLKDEHTVAYYLKGDMSQEETITAKYILIATGCRPHIPEDVEGARELSITSDD 218

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           IF MK K PGKTL+VGASYVALECAGFL  +G+ V V VRSI+LRGFD   A K+  YME
Sbjct: 219 IFSMK-KVPGKTLIVGASYVALECAGFLNSLGFDVTVAVRSIVLRGFDSQCALKVKNYME 277

Query: 238 MQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDE 297
            Q G+ F    +P+ ++K +  ++ V +     D   E +DTVL ATGR  D+A L L+ 
Sbjct: 278 EQ-GVLFKEGVLPKKLSKGEEDKVAVLFT----DGTTELYDTVLYATGRKGDIAMLHLER 332

Query: 298 AGVKLNEKTGRIWVNNEQ-TTTPNVYAIGDV-IDAPELTPVAIQAGRLLSRRLYNEGTVQ 355
             + +++   +I  N    T  PN++A+GDV +D PEL PVAI+AG +L+RRL+ +    
Sbjct: 333 LNIHVDKSANKIITNEGSCTNVPNIFAVGDVAVDVPELAPVAIKAGEILARRLFKQSQEI 392

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR------ 409
           MDY  I TA++TPIEYG CG SEE + E +G  +VEV+ + F  LE S   + +      
Sbjct: 393 MDYTFIPTAIYTPIEYGACGYSEEKAYEAFGTSNVEVFLQEFNNLEISAVHREKHVRAQK 452

Query: 410 -----IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVG 464
                  + +C  K+VC K+ +N V+GFHY+GPNAGEVTQ M LA++L          VG
Sbjct: 453 DQYDTDVSSTCLSKLVCLKSEDNRVVGFHYVGPNAGEVTQGMALALRLKARKSDFDSCVG 512

Query: 465 IHP 467
           IHP
Sbjct: 513 IHP 515


>ref|XP_002808951.1| thioredoxin reductase [Plasmodium falciparum 3D7]
 sp|P61076|TRXR2_PLAF7 RecName: Full=Thioredoxin reductase 2; Short=TrxR2
 gb|AAQ07981.1|AF508128_1 thioredoxin reductase 2 [Plasmodium falciparum]
 emb|CAX64232.1| thioredoxin reductase [Plasmodium falciparum 3D7]
          Length = 617

 Score =  386 bits (992), Expect = e-105
 Identities = 220/484 (45%), Positives = 299/484 (61%), Gaps = 29/484 (5%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYD VVIGGG GG+A +KEAA+ G +V + DYVKPS  GT WG+GGTCVNVGC+PKKL
Sbjct: 115 TYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKL 174

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH +  +G I   D  ++GW   ++       DWK+LV+ V              LRS +
Sbjct: 175 MHYAGHMGSIFKLDSKAYGWKFDNLK-----HDWKKLVTTVQSHIRSLNFSYMTGLRSSK 229

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSD 176
           VKY N L    D +T+  +     +KE  +T ++++IA G RP     + G  EL+++SD
Sbjct: 230 VKYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSD 289

Query: 177 DIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYM 236
           DIF +K K+PGKTLVVGASYVALEC+GFL  +GY V V VRSI+LRGFDQ  A K+  YM
Sbjct: 290 DIFSLK-KDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYM 348

Query: 237 EMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           E Q G+ F    +P+ +TK+D      K + E  D   E +DTVL A GR  D+  L L+
Sbjct: 349 EEQ-GVMFKNGILPKKLTKMDD-----KILVEFSDKTSELYDTVLYAIGRKGDIDGLNLE 402

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRLYNEGTV 354
              + +N+   +I  ++   T  P+++A+GDV +  PEL PVAI+AG +L+RRL+ +   
Sbjct: 403 SLNMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDE 462

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWS-LAEQTRIAAE 413
            MDY  I T+++TPIEYG CG SEE + E YG  +VEV+ + F  LE S +  Q  I A+
Sbjct: 463 IMDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQ 522

Query: 414 ----------SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTV 463
                     +C  K+VC K  +N V+GFHY+GPNAGEVTQ M LA++L        + +
Sbjct: 523 KDEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCI 582

Query: 464 GIHP 467
           GIHP
Sbjct: 583 GIHP 586


>ref|XP_001011080.1| thioredoxin and glutathione reductase family protein [Tetrahymena
           thermophila]
 gb|EAR90835.1| thioredoxin and glutathione reductase family protein [Tetrahymena
           thermophila SB210]
          Length = 485

 Score =  386 bits (992), Expect = e-105
 Identities = 214/467 (45%), Positives = 296/467 (63%), Gaps = 16/467 (3%)

Query: 3   DYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMH 62
           ++D  VIGGGSGGLA SKEAA FG KV + D+V P+P GT WGLGGTCVNVGCIPKKLMH
Sbjct: 8   EFDFFVIGGGSGGLAASKEAAQFGVKVGLADFVDPTPIGTKWGLGGTCVNVGCIPKKLMH 67

Query: 63  QSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVK 122
            ++  GE +     S GW   +VN +  T +W++LV  V            V LR  +VK
Sbjct: 68  YAATYGESMEMQRIS-GWK--NVNEEQKTHEWQKLVERVQNNVKKTNFGYKVALRENKVK 124

Query: 123 YENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGELAVSSDDIFWMK 182
           Y N   S VD +T+KL   K G   +  +H++I+VGGRP  L  +  +L ++SDD+F + 
Sbjct: 125 YFNYYASLVDKNTIKL-ENKTGVIYVKAKHILISVGGRPNYLPHIDSKLIITSDDLFSL- 182

Query: 183 QKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSGI 242
           Q  PGKTL+ G SY+ALECAGFL G+GY V V+ RS+LLRGFDQD+A ++  YM    G+
Sbjct: 183 QTPPGKTLIAGGSYIALECAGFLNGLGYDVTVLYRSVLLRGFDQDVAERMQTYM-AHHGV 241

Query: 243 EFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKL 302
           +F++  + + + +L++    V +     D    TF+TVL A GR P+  KLGL+  G+ +
Sbjct: 242 KFVQGEI-KDVKQLENETKQVVYTNGSSD----TFNTVLLAIGRIPNTKKLGLENVGIPV 296

Query: 303 NEKTGRIWVNN-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDYDK 360
             K+G+I  ++ ++TT  N+YAIGD ++   ELTP+AI+AGR L+RRLYN   + +DY  
Sbjct: 297 T-KSGKIQSDDLDRTTVENIYAIGDAVEGRMELTPLAIKAGRYLARRLYNNENISLDYKI 355

Query: 361 ICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVV 420
           + T VFTPIEY   GL+EE++ + YG ++V  Y   F PLEW L+++   +   C  K++
Sbjct: 356 VPTTVFTPIEYSAIGLTEEEAIKTYGSENVWSYVSKFKPLEWVLSDKDNDSRGYC--KLI 413

Query: 421 CDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
               +N  VLG HYLGP+A EV Q   +AM+LG T      TV IHP
Sbjct: 414 VHNKQNERVLGLHYLGPHAAEVAQGFAVAMQLGATKADFDKTVAIHP 460


>sp|Q25861|TRXR_PLAF5 RecName: Full=Thioredoxin reductase; Short=TrxR
 emb|CAA60574.1| thioredoxin reductase [Plasmodium falciparum]
          Length = 541

 Score =  386 bits (992), Expect = e-105
 Identities = 220/484 (45%), Positives = 299/484 (61%), Gaps = 29/484 (5%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYD VVIGGG GG+A +KEAA+ G +V + DYVKPS  GT WG+GGTCVNVGC+PKKL
Sbjct: 39  TYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKL 98

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH +  +G I   D  ++GW   ++       DWK+LV+ V              LRS +
Sbjct: 99  MHYAGHMGSIFKLDSKAYGWKFDNLK-----HDWKKLVTTVQSHIRSLNFSYMTGLRSSK 153

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSD 176
           VKY N L    D +T+  +     +KE  +T ++++IA G RP     + G  EL+++SD
Sbjct: 154 VKYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSD 213

Query: 177 DIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYM 236
           DIF +K K+PGKTLVVGASYVALEC+GFL  +GY V V VRSI+LRGFDQ  A K+  YM
Sbjct: 214 DIFSLK-KDPGKTLVVGASYVALECSGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYM 272

Query: 237 EMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           E Q G+ F    +P+ +TK+D      K + E  D   E +DTVL A GR  D+  L L+
Sbjct: 273 EEQ-GVMFKNGILPKKLTKMDD-----KILVEFSDKTSELYDTVLYAIGRKGDIDGLNLE 326

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRLYNEGTV 354
              + +N+   +I  ++   T  P+++A+GDV +  PEL PVAI+AG +L+RRL+ +   
Sbjct: 327 SLNMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDE 386

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWS-LAEQTRIAAE 413
            MDY  I T+++TPIEYG CG SEE + E YG  +VEV+ + F  LE S +  Q  I A+
Sbjct: 387 IMDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQ 446

Query: 414 ----------SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTV 463
                     +C  K+VC K  +N V+GFHY+GPNAGEVTQ M LA++L        + +
Sbjct: 447 KDEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCI 506

Query: 464 GIHP 467
           GIHP
Sbjct: 507 GIHP 510


>ref|XP_666572.1| thioredoxin reductase [Cryptosporidium hominis TU502]
 gb|EAL36345.1| thioredoxin reductase [Cryptosporidium hominis]
          Length = 521

 Score =  385 bits (989), Expect = e-105
 Identities = 213/481 (44%), Positives = 301/481 (62%), Gaps = 29/481 (6%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++ YDLVVIGGGSGG+A +KEAA +GKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 25  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 84

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH S+LI   +HHD   FG    S      +F+W +LV  +              LR   
Sbjct: 85  MHYSALISSSIHHDAQMFGHKTSS------SFEWGKLVETLRNHIRMLNFSYRTGLRVGN 138

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V+Y N L   +DPH+++ +      K IT+R++++A GGRP     + G  + +++SDDI
Sbjct: 139 VEYINALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDI 197

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F++  K PGKTLV+GASY+ LE AGFL  +G+   V +RSI LRGFD+  + KI EYM+ 
Sbjct: 198 FFL-SKSPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMK- 255

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            +G +F+   VP +I K++     +K    DG    E F+TVL ATGR+PDV  L L+  
Sbjct: 256 ATGTKFLVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAV 310

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV++++ +G+I    + T+ P+++A+GD+++  PELTPVA++AG LL+RRL+      +D
Sbjct: 311 GVEVSD-SGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFID 369

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR-------- 409
           YD + T VFTPIEYG  GLS E +  +YG+D +E Y   F  LE + A + +        
Sbjct: 370 YDFVPTTVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENE 429

Query: 410 ---IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
                  +C  K+V  K++   V+GFH++GPNAGE+TQ   LA+KLG T     D +GIH
Sbjct: 430 MDFALPLNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIH 489

Query: 467 P 467
           P
Sbjct: 490 P 490


>dbj|BAJ77264.1| cgd2_4320 [Cryptosporidium parvum]
 dbj|BAJ78027.1| cgd2_4320 [Cryptosporidium parvum]
          Length = 508

 Score =  385 bits (988), Expect = e-104
 Identities = 213/481 (44%), Positives = 301/481 (62%), Gaps = 29/481 (6%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++ YDLVVIGGGSGG+A +KEAA +GKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 12  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 71

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH S+LI   +HHD   FG    S      +F+W +LV  +              LR   
Sbjct: 72  MHYSALIASSIHHDAQMFGHKTSS------SFEWGKLVETLRNHIRMLNFSYRTGLRVGN 125

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V+Y N L   +DPH+++ +      K IT+R++++A GGRP     + G  + +++SDDI
Sbjct: 126 VEYINALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDI 184

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F++  K PGKTLV+GASY+ LE AGFL  +G+   V +RSI LRGFD+  + KI EYM+ 
Sbjct: 185 FFL-SKSPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMK- 242

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            +G +F+   VP +I K++     +K    DG    E F+TVL ATGR+PDV  L L+  
Sbjct: 243 ATGTKFLVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAI 297

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV++++ +G+I    + T+ P+++A+GD+++  PELTPVA++AG LL+RRL+      +D
Sbjct: 298 GVEVSD-SGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFID 356

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR-------- 409
           YD + T VFTPIEYG  GLS E +  +YG+D +E Y   F  LE + A + +        
Sbjct: 357 YDFVPTTVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENE 416

Query: 410 ---IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
                  +C  K+V  K++   V+GFH++GPNAGE+TQ   LA+KLG T     D +GIH
Sbjct: 417 MDFALPLNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIH 476

Query: 467 P 467
           P
Sbjct: 477 P 477


>gb|AAN05789.1| putative thioredoxin reductase [Cryptosporidium parvum]
          Length = 521

 Score =  385 bits (988), Expect = e-104
 Identities = 213/481 (44%), Positives = 301/481 (62%), Gaps = 29/481 (6%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++ YDLVVIGGGSGG+A +KEAA +GKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 25  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 84

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH S+LI   +HHD   FG    S      +F+W +LV  +              LR   
Sbjct: 85  MHYSALIASSIHHDAQMFGHKTSS------SFEWGKLVETLRNHIRMLNFSYRTGLRVGN 138

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V+Y N L   +DPH+++ +      K IT+R++++A GGRP     + G  + +++SDDI
Sbjct: 139 VEYINALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDI 197

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F++  K PGKTLV+GASY+ LE AGFL  +G+   V +RSI LRGFD+  + KI EYM+ 
Sbjct: 198 FFL-SKSPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMK- 255

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            +G +F+   VP +I K++     +K    DG    E F+TVL ATGR+PDV  L L+  
Sbjct: 256 ATGTKFLVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAI 310

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV++++ +G+I    + T+ P+++A+GD+++  PELTPVA++AG LL+RRL+      +D
Sbjct: 311 GVEVSD-SGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFID 369

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR-------- 409
           YD + T VFTPIEYG  GLS E +  +YG+D +E Y   F  LE + A + +        
Sbjct: 370 YDFVPTTVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENE 429

Query: 410 ---IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
                  +C  K+V  K++   V+GFH++GPNAGE+TQ   LA+KLG T     D +GIH
Sbjct: 430 MDFALPLNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIH 489

Query: 467 P 467
           P
Sbjct: 490 P 490


>ref|XP_626611.1| thioredoxin reductase 1 [Cryptosporidium parvum Iowa II]
 gb|EAK88893.1| thioredoxin reductase 1 [Cryptosporidium parvum Iowa II]
          Length = 526

 Score =  385 bits (988), Expect = e-104
 Identities = 213/481 (44%), Positives = 301/481 (62%), Gaps = 29/481 (6%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++ YDLVVIGGGSGG+A +KEAA +GKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 30  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 89

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH S+LI   +HHD   FG    S      +F+W +LV  +              LR   
Sbjct: 90  MHYSALIASSIHHDAQMFGHKTSS------SFEWGKLVETLRNHIRMLNFSYRTGLRVGN 143

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V+Y N L   +DPH+++ +      K IT+R++++A GGRP     + G  + +++SDDI
Sbjct: 144 VEYINALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDI 202

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F++  K PGKTLV+GASY+ LE AGFL  +G+   V +RSI LRGFD+  + KI EYM+ 
Sbjct: 203 FFL-SKSPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMK- 260

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            +G +F+   VP +I K++     +K    DG    E F+TVL ATGR+PDV  L L+  
Sbjct: 261 ATGTKFLVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAI 315

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV++++ +G+I    + T+ P+++A+GD+++  PELTPVA++AG LL+RRL+      +D
Sbjct: 316 GVEVSD-SGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFID 374

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR-------- 409
           YD + T VFTPIEYG  GLS E +  +YG+D +E Y   F  LE + A + +        
Sbjct: 375 YDFVPTTVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENE 434

Query: 410 ---IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
                  +C  K+V  K++   V+GFH++GPNAGE+TQ   LA+KLG T     D +GIH
Sbjct: 435 MDFALPLNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIH 494

Query: 467 P 467
           P
Sbjct: 495 P 495


>ref|XP_003137903.1| thioredoxin reductase [Loa loa]
 gb|EFO26173.1| thioredoxin reductase [Loa loa]
          Length = 637

 Score =  384 bits (985), Expect = e-104
 Identities = 225/481 (46%), Positives = 298/481 (61%), Gaps = 27/481 (5%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           + YDL V+GGGSGGLA +KEA   GKKV  LD+VKPS  GT+WGLGGTCVNVGCIPKKLM
Sbjct: 145 HQYDLAVVGGGSGGLAAAKEAVRLGKKVVCLDFVKPSTMGTTWGLGGTCVNVGCIPKKLM 204

Query: 62  HQSSLIGEILHHDCASFGWNV--GSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSK 119
           HQ++L+GE +  D   FGW +  G++       +W QL + +            V+LR +
Sbjct: 205 HQAALLGEYI-EDAKKFGWEIPEGAIK-----LNWHQLKNAIQNHITSLNWAYRVQLRER 258

Query: 120 QVKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDI 178
            V Y N   +F   H L + + K   +++T    +IAVG RPR     G  E  +SSDD+
Sbjct: 259 SVTYMNSYATFTGSHELSVKNKKGKVEKVTADRFLIAVGLRPRFPDVPGVLECCISSDDL 318

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +    PGKTL VGASYV+LECAGFL+G+G  V VMVRSILLRG DQDMA +I ++M +
Sbjct: 319 FSLPY-NPGKTLCVGASYVSLECAGFLRGIGNDVTVMVRSILLRGLDQDMAERIKKHM-I 376

Query: 239 QSGIEFIRKTVPQSITKL------DSGQLLVKWI--TEDGDCFE--ETFDTVLNATGRDP 288
           + G++F+   +P    KL      + G + V  +   EDG   E  E F+TVL A GRD 
Sbjct: 377 EHGVKFV-PYIPIKYEKLKEPTNNEPGLIRVHTVQEREDGTKEEVAEEFNTVLMAIGRDA 435

Query: 289 DVAKLGLDEAGVKLNEKTGRIWVNNEQTTT-PNVYAIGDVI-DAPELTPVAIQAGRLLSR 346
               LGLD  GV   E  G+I    EQ+ + P VYAIGDV+  +PELTPVAIQAG++L R
Sbjct: 436 MTGDLGLDLVGVDCTE-FGKIIGRREQSVSCPYVYAIGDVLHGSPELTPVAIQAGKVLMR 494

Query: 347 RLYNEGTVQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAE 406
           RL+   +   +Y K+ T VFTP+EYG CGLSE+ + ++YG +++ VYH  F+PLE+++ E
Sbjct: 495 RLFTGNSELTEYGKVPTTVFTPLEYGSCGLSEDAAIQKYGKENINVYHNMFIPLEYAVTE 554

Query: 407 QTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
             R     CY K++C K   + VLGFH L PNAGE+TQ   +A+K           +GIH
Sbjct: 555 --RKEKTHCYCKLICLKKEQDLVLGFHILAPNAGEITQGFAIALKFDAKKADFDRLIGIH 612

Query: 467 P 467
           P
Sbjct: 613 P 613


>emb|CAG09709.1| unnamed protein product [Tetraodon nigroviridis]
          Length = 472

 Score =  383 bits (984), Expect = e-104
 Identities = 223/472 (47%), Positives = 288/472 (61%), Gaps = 32/472 (6%)

Query: 2   YDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLM 61
           YDYDLVVIGGGSGGLACSKEAA  G+ V VLDYV+PS  GT WGLGGTCVNVGCIPKKLM
Sbjct: 3   YDYDLVVIGGGSGGLACSKEAAQLGQNVAVLDYVEPSIKGTKWGLGGTCVNVGCIPKKLM 62

Query: 62  HQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQV 121
           HQ++L+G  +  D   +GW +     +  + DW  +   V            V+L+ K+V
Sbjct: 63  HQAALLGTAV-KDAKKYGWQI----PEPISHDWAAMAEAVQNHVRSLNWGHRVQLQDKKV 117

Query: 122 KYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSDD 177
           KY N+ GS VD HT+K     K  KE  +T +++VIA GGRP+    + G  E  ++SDD
Sbjct: 118 KYLNMRGSLVDEHTVK--GVTKAGKETILTAKNIVIATGGRPKYPTDIPGATEHGITSDD 175

Query: 178 IFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYME 237
           IFW++ K PGKT     S VALECAGFL G+G    VMVRSI LRGFDQ MA+ + +YME
Sbjct: 176 IFWLR-KSPGKT-----SDVALECAGFLTGIGLDATVMVRSIALRGFDQQMAALVTDYME 229

Query: 238 MQSGIEFIRKTVPQSITKLDSGQLLVKWI-TEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
              G +F  K +P+ + K+ SG L V W         ++T+D VL A G      K    
Sbjct: 230 TY-GTKFAWKCIPKRVEKMPSGALQVTWTDLNTSKEQQDTYDCVLWAVGIP---TKPQQR 285

Query: 297 EAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQ 355
            +    N  +G+ W         NV      +   PELTP AI+AG+LL+ RL    T  
Sbjct: 286 PSPRNKNPGSGQAW------CAKNVRIFFFSLQGRPELTPTAIKAGKLLAHRLAGRSTEL 339

Query: 356 MDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESC 415
           M+Y  + T VFTP+EYGC GLSEED+++ +G D +EVYH  + PLE+++AE+    A  C
Sbjct: 340 MNYHNVPTTVFTPLEYGCVGLSEEDAEKRHGKDRIEVYHAFYKPLEFTVAERD---ASQC 396

Query: 416 YVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           Y+KVVC+      +LG H+ GPNAGEVTQ   L++K G TY  L+ TVGIHP
Sbjct: 397 YLKVVCEGDGGQKILGLHFTGPNAGEVTQGFALSLKCGATYSHLLQTVGIHP 448


>ref|XP_745009.1| Thioredoxin reductase [Plasmodium chabaudi chabaudi]
 emb|CAH79243.1| Thioredoxin reductase, putative [Plasmodium chabaudi chabaudi]
          Length = 532

 Score =  383 bits (983), Expect = e-104
 Identities = 215/484 (44%), Positives = 303/484 (62%), Gaps = 29/484 (5%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYD +VIGGG GG+A +KEAAS G KV + D+VKPS  GT WG+GGTCVNVGC+PKKL
Sbjct: 30  NYDYDYIVIGGGPGGMASAKEAASHGAKVLLFDFVKPSTQGTKWGIGGTCVNVGCVPKKL 89

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH +  +G +  +D   +GW+  ++       DW +LVS V            V L+S +
Sbjct: 90  MHYAGNMGTLFKNDSEKYGWDCDNLK-----HDWNKLVSTVQSHIRSLNFSYMVGLKSSK 144

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSD 176
           VKY N L    D +T+  +     +KE  +T +++++A G RP     + G  EL+++SD
Sbjct: 145 VKYINGLAKLKDKNTVSYYLKGDTSKEECVTGKYILVATGCRPNIPDDVIGAKELSITSD 204

Query: 177 DIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYM 236
           DIF +K + PGKTLVVGASYVALECAGFL  +GY V + VRSI+LRGFDQ  A+KI  YM
Sbjct: 205 DIFSLK-RCPGKTLVVGASYVALECAGFLNSLGYDVTISVRSIILRGFDQQCANKIKLYM 263

Query: 237 EMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           E Q G+ F+   +P+ +TK ++ ++LV +  +      E FDTVL A GR  D+  L L+
Sbjct: 264 EEQ-GVTFMTGVLPKKLTK-ENDKILVHFNNDT----TEVFDTVLYAIGRKGDIDGLNLE 317

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRLYNEGTV 354
           +  + +N    +I  +    T  PN++A+GD+ +  PEL PVAI+AG +L+RRL+     
Sbjct: 318 KLNININNNNKKIIADQFSCTNIPNIFAVGDIAENVPELAPVAIKAGEILARRLFKNSNE 377

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR-IAAE 413
            M YD I T+++TPIEYG CG SEE + E +G +++EV+ + F  LE S   + + I A+
Sbjct: 378 IMKYDFIPTSIYTPIEYGSCGYSEEKAYEIFGKNNIEVFLQEFNNLEISAVHRIKHIKAQ 437

Query: 414 ----------SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTV 463
                     +C+ K+VC K  +N V+GFHY+GPNAGEVTQ M LA+KL        + +
Sbjct: 438 KDEYDVDISSTCFSKLVCLKNEDNRVVGFHYVGPNAGEVTQGMALALKLNAKKSDFDNCI 497

Query: 464 GIHP 467
           GIHP
Sbjct: 498 GIHP 501


>ref|XP_001519650.1| PREDICTED: hypothetical protein, partial [Ornithorhynchus anatinus]
          Length = 407

 Score =  382 bits (981), Expect = e-104
 Identities = 214/398 (53%), Positives = 265/398 (66%), Gaps = 14/398 (3%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           SY+YDL+VIGGGSGGLACSKEAA+ GKKV VLD+V PSP GTSWGLGGTCVNVGCIPKKL
Sbjct: 17  SYEYDLIVIGGGSGGLACSKEAATLGKKVMVLDFVVPSPVGTSWGLGGTCVNVGCIPKKL 76

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MHQ++L+G+ L  D   FGW       Q    +WK +   +            V LR K 
Sbjct: 77  MHQAALLGQAL-QDSRKFGWEY----EQQVKHNWKTMTEAIQNYIGSLNWGYRVTLREKA 131

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG-ELAVSSDDIF 179
           V Y N  G FVD H +K  + K      T    VIA G RPR L   G  E  ++SDD+F
Sbjct: 132 VTYSNSFGEFVDHHKIKATNRKGQETFHTASKFVIATGERPRYLGIPGDKEYCITSDDLF 191

Query: 180 WMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQ 239
            +    PGKTLVVGASYVALECAGFL G+G  V VMVRSILLRGFDQ+MA K+G YME+ 
Sbjct: 192 SLPYC-PGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQEMAEKVGAYMELH 250

Query: 240 SGIEFIRKTVPQSITKLDSGQ----LLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGL 295
            G++FIRK VP  I +L+ G      +    TE     EE F+T+L A GRD    K+GL
Sbjct: 251 -GVKFIRKFVPFLIEQLEEGAPGKLKMTARSTEGESIIEEEFNTILIAVGRDACTKKIGL 309

Query: 296 DEAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVIDAP-ELTPVAIQAGRLLSRRLYNEGT 353
           ++ GVK+NEK G+I V++ EQT  P VYAIGD+++   ELTPVAIQAG+LL+RRL+   +
Sbjct: 310 EKIGVKVNEKNGKIPVSDEEQTNVPYVYAIGDILEGKLELTPVAIQAGKLLARRLFGGYS 369

Query: 354 VQMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVE 391
            + DY  + T VFTP+EYGCCG+SEE + E++  D++E
Sbjct: 370 EKCDYINVPTTVFTPLEYGCCGMSEEKAIEQHKKDNLE 407


>gb|ACV31866.1| thioredoxin reductase [Cryptosporidium parvum]
          Length = 521

 Score =  382 bits (980), Expect = e-104
 Identities = 212/481 (44%), Positives = 300/481 (62%), Gaps = 29/481 (6%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           ++ YDLVVIGGGSGG+A +KEAA +GKKV + D+VKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 25  TFMYDLVVIGGGSGGMAAAKEAAKYGKKVALFDFVKPSTQGTKWGLGGTCVNVGCVPKKL 84

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH S+LI   +HHD    G    S      +F+W +LV  +              LR   
Sbjct: 85  MHYSALIASSIHHDAQMSGHKTSS------SFEWGKLVETLRNHIRMLNFSYRTGLRVGN 138

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V+Y N L   +DPH+++ +      K IT+R++++A GGRP     + G  + +++SDDI
Sbjct: 139 VEYINALAKLIDPHSVE-YEDNGQKKTITSRYILLATGGRPSIPETVPGAIQYSITSDDI 197

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F++  K PGKTLV+GASY+ LE AGFL  +G+   V +RSI LRGFD+  + KI EYM+ 
Sbjct: 198 FFL-SKSPGKTLVIGASYIGLETAGFLNELGFDTTVAMRSIPLRGFDRQCSEKIVEYMK- 255

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
            +G +F+   VP +I K++     +K    DG    E F+TVL ATGR+PDV  L L+  
Sbjct: 256 ATGTKFLVGVVPINIEKVNEN---IKVSFSDGSV--EEFETVLYATGRNPDVKGLNLNAI 310

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV++++ +G+I    + T+ P+++A+GD+++  PELTPVA++AG LL+RRL+      +D
Sbjct: 311 GVEVSD-SGKIIAPKDATSVPSIFAVGDIVEGRPELTPVAVKAGILLARRLFAGSNEFID 369

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR-------- 409
           YD + T VFTPIEYG  GLS E +  +YG+D +E Y   F  LE + A + +        
Sbjct: 370 YDFVPTTVFTPIEYGHVGLSSEAAIAKYGEDDIEEYLSEFSTLEIAAAHREKPEHLRENE 429

Query: 410 ---IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
                  +C  K+V  K++   V+GFH++GPNAGE+TQ   LA+KLG T     D +GIH
Sbjct: 430 MDFALPLNCLAKLVVVKSQGEKVVGFHFVGPNAGEITQGFSLAVKLGATKKDFDDMIGIH 489

Query: 467 P 467
           P
Sbjct: 490 P 490


>ref|XP_730274.1| thioredoxin reductase [Plasmodium yoelii yoelii str. 17XNL]
 gb|EAA21839.1| thioredoxin reductase [Plasmodium yoelii yoelii]
          Length = 638

 Score =  379 bits (974), Expect = e-103
 Identities = 212/484 (43%), Positives = 298/484 (61%), Gaps = 29/484 (5%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           +YDYD +VIGGG GG+A +KEAAS G KV + D+VKPS  GT WG+GGTCVNVGC+PKKL
Sbjct: 136 NYDYDYIVIGGGPGGMASAKEAASHGAKVLLFDFVKPSSQGTKWGIGGTCVNVGCVPKKL 195

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           MH +  +G +   D   +GW   ++       DW +LVS V            V L+S +
Sbjct: 196 MHYAGNMGTLFKSDSDKYGWECDNLK-----HDWNKLVSTVQSHIRSLNFSYMVGLKSSK 250

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKE--ITTRHVVIAVGGRPRQLACLGG--ELAVSSD 176
           VKY N L    D +T+  +     +KE  +T ++++IA G RP     + G  EL+++SD
Sbjct: 251 VKYINGLAKLKDKNTVSYYLKGDTSKEDCVTGKYILIATGCRPNIPDDVIGAKELSITSD 310

Query: 177 DIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYM 236
           DIF +K K PGKTLVVGASYVALECAGFL  +G    + VRSI+LRGFDQ  A+KI  YM
Sbjct: 311 DIFSLK-KNPGKTLVVGASYVALECAGFLNSLGCDTTISVRSIILRGFDQQCANKIKLYM 369

Query: 237 EMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLD 296
           E Q G+ F+   +P+ +TK ++ ++LV +     +   E FDTVL A GR  D+  L L+
Sbjct: 370 EEQ-GVTFMCGVLPKKLTK-ENDKILVHF----NNNTTELFDTVLYAIGRKGDIDGLNLE 423

Query: 297 EAGVKLNEKTGRIWVNN-EQTTTPNVYAIGDVID-APELTPVAIQAGRLLSRRLYNEGTV 354
           +  + +N    +I  +    T  PN++A+GD+ +  PEL PVAI+AG +L+RRL+     
Sbjct: 424 KLNININNNNNKIITDKFSCTNIPNIFAVGDIAENVPELAPVAIKAGEILARRLFKNSNE 483

Query: 355 QMDYDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTR----- 409
            M Y+ I T+++TPIEYG CG SEE + E++G +++E++ + F  LE S   +T+     
Sbjct: 484 IMKYNLIPTSIYTPIEYGSCGYSEEQAYEQFGKNNIEIFLQEFNNLEISAVHRTKHLKVQ 543

Query: 410 ------IAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTV 463
                   + +C  K+VC K  +N V+GFHY+GPNAGEVTQ M LA+KL        + +
Sbjct: 544 KDEYDVDISSTCLSKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALKLNAKKSDFDNCI 603

Query: 464 GIHP 467
           GIHP
Sbjct: 604 GIHP 607


>ref|XP_002142781.1| thioredoxin reductase [Cryptosporidium muris RN66]
 gb|EEA08432.1| thioredoxin reductase, putative [Cryptosporidium muris RN66]
          Length = 506

 Score =  377 bits (968), Expect = e-102
 Identities = 218/481 (45%), Positives = 291/481 (60%), Gaps = 29/481 (6%)

Query: 1   SYDYDLVVIGGGSGGLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKL 60
           S+ YDL+VIGGGSGGLA +KEAA  GKKV + DYVKPS  GT WGLGGTCVNVGC+PKKL
Sbjct: 10  SFMYDLIVIGGGSGGLAAAKEAARLGKKVALFDYVKPSTQGTKWGLGGTCVNVGCVPKKL 69

Query: 61  MHQSSLIGEILHHDCASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQ 120
           +H ++ IG ILHHD +++G+ V S      TF W  L+  V              L S  
Sbjct: 70  IHYAANIGTILHHDTSNYGFEVTS------TFRWSNLIQTVQNHVKSLNFSYRSGLFSSG 123

Query: 121 VKYENVLGSFVDPHTLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGG--ELAVSSDDI 178
           V+Y N L +  D HT+ L+       + TT H++IAVGGRP     + G  E A++SDDI
Sbjct: 124 VEYINSLANLEDRHTV-LFKRNNEIMKYTTEHILIAVGGRPNISESVPGALEYAITSDDI 182

Query: 179 FWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEM 238
           F +  K PGKTL+VGASY+ LE AGFL  +G+   V VRSI LRGFD+  + K+   M+ 
Sbjct: 183 FSL-SKPPGKTLIVGASYIGLETAGFLTELGFEAIVAVRSIPLRGFDRQCSEKVVSMMK- 240

Query: 239 QSGIEFIRKTVPQSITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEA 298
           + G  F+   VP +I K+D     +K +  +G  + E FDTV+ ATGR PD   L L+E 
Sbjct: 241 EYGTRFLEGVVPINIEKIDDE---LKVVFSNG--YTEQFDTVIYATGRYPDTKYLKLNEI 295

Query: 299 GVKLNEKTGRIWVNNEQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMD 357
           GV L     +I   N+ T  PN++AIGDV+D  PELTPVAI+AG LL+RRL+      +D
Sbjct: 296 GVHLT-SNNKIIAPNDTTNIPNIHAIGDVVDGRPELTPVAIKAGILLARRLFGNSKEFID 354

Query: 358 YDKICTAVFTPIEYGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAE---- 413
           Y  I T +FTPIEYG  G S E +  EYG+D +E Y   F  LE + + + ++ +     
Sbjct: 355 YKYIPTTIFTPIEYGSIGYSSEAAIAEYGEDDIEEYLFEFTTLEIAASHRYKVESSRMDS 414

Query: 414 -------SCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIH 466
                  + + K++  K+ +N V+GFH++G NAGE+TQ   LA+KLG         +GIH
Sbjct: 415 GDFYMSPNSFAKLITVKSLDNKVIGFHFVGLNAGEITQGFSLAIKLGTKKSDFDSMIGIH 474

Query: 467 P 467
           P
Sbjct: 475 P 475


>ref|XP_002680287.1| predicted protein [Naegleria gruberi]
 gb|EFC47543.1| predicted protein [Naegleria gruberi]
          Length = 530

 Score =  376 bits (966), Expect = e-102
 Identities = 216/499 (43%), Positives = 308/499 (61%), Gaps = 43/499 (8%)

Query: 4   YDLVVIGGGSGGLACSKEAASFGKK---VCVLDYVKPSP----------HGTSWGLGGTC 50
           +D +VIGGGSGGL+ SK+ +S   K   +C+LDY  PS           +G  W LGGTC
Sbjct: 16  FDYIVIGGGSGGLSLSKQLSSLSSKETRICLLDYRDPSSQWLRERNGKLNGWMWQLGGTC 75

Query: 51  VNVGCIPKKLMHQSSLIGEILHHDCASFGWNVGSVNGQVP-TFDWKQLVSNVXXXXXXXX 109
           VNVGCIPKKLMH S+LIGE ++HD   FGWN G   G++    DWK LV+NV        
Sbjct: 76  VNVGCIPKKLMHNSALIGEGINHDAEYFGWNDGKQEGKLSGKHDWKTLVANVQQYIKSLN 135

Query: 110 XXXXVELRS-----------KQVKYENVLGSFVDPHTLKLWHPKKG-TKEITTRHVVIAV 157
                 +             K++ Y N+ G FVD HTL+L  P+KG TK I+ + ++++V
Sbjct: 136 FGYRTSVTQTYAFDNEDPSLKKLYYLNMKGRFVDDHTLELTDPRKGITKTISGKVIILSV 195

Query: 158 GGRPRQLACLGG--ELAVSSDDIFWMKQKEPGKTLVVGASYVALECAGFLKGMGYAVKVM 215
           GG P     + G  E A++SDDIF +K+ EPGKTLV+GASY+ALE A FLKG+GY   VM
Sbjct: 196 GGTPNIPQDVPGATEYAITSDDIFSLKE-EPGKTLVIGASYIALETASFLKGLGYESSVM 254

Query: 216 VRSILLRGFDQDMASKIGEYMEMQSGIEFIRKTVPQSITKLDSGQLLVKWITEDGD---- 271
           +RSI LRGFDQ+ A K+ + M+ + G++F+ + +P  I K    +   ++     D    
Sbjct: 255 MRSIPLRGFDQECAWKVVDGMK-ERGVKFLEQCIPVKIEKSSDHETTGEYTVHYKDLSTQ 313

Query: 272 -CFEETFDTVLNATGRDPDVAKLGLDEAGVKLNEKTGRIWVNNEQTTTPNVYAIGDVID- 329
             + E + T++ A GR     +L +D   + ++E    I  +NEQT+  ++YAIGD I+ 
Sbjct: 314 QVYTENYKTIMFAVGRRAVTKELNID---LDMDESGKIIVSDNEQTSKKHIYAIGDCINK 370

Query: 330 APELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFT-PIEYGCCGLSEEDSKEEYGDD 388
             ELTPVAI+AG+LL+ RL N+GT  MDYD + T++FT P EYGCCGLSEE++ + YG+D
Sbjct: 371 KTELTPVAIRAGKLLASRLTNKGTELMDYDNVPTSIFTHPYEYGCCGLSEEEAVQRYGED 430

Query: 389 SVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVCDKTRNNFVLGFHYLGPNAGEVTQAMGL 448
            +EVY   + P+E  L+ +        ++K++  K+ N  V+GFHY+G NAGE+TQ + +
Sbjct: 431 DIEVYISLYSPIEHQLSHRD---TNKTFMKIITLKSANEKVIGFHYVGANAGEITQGIAV 487

Query: 449 AMKLGFTYDQLVDTVGIHP 467
           A+K G T +   +T+GIHP
Sbjct: 488 AIKAGATKEHFDNTIGIHP 506


>ref|XP_002404402.1| thioredoxin reductase, putative [Ixodes scapularis]
 gb|EEC09890.1| thioredoxin reductase, putative [Ixodes scapularis]
          Length = 497

 Score =  376 bits (965), Expect = e-102
 Identities = 208/457 (45%), Positives = 280/457 (61%), Gaps = 13/457 (2%)

Query: 15  GLACSKEAASFGKKVCVLDYVKPSPHGTSWGLGGTCVNVGCIPKKLMHQSSLIGEILHHD 74
           G+  +  A + G    VLD+V+PSP G+ WGLGGTCVNVGCIPKKL HQ +L+GE L  D
Sbjct: 26  GVTFATRAQALGLSAAVLDFVEPSPRGSFWGLGGTCVNVGCIPKKLFHQGALLGEALE-D 84

Query: 75  CASFGWNVGSVNGQVPTFDWKQLVSNVXXXXXXXXXXXXVELRSKQVKYENVLGSFVDPH 134
              FGW +       P  DW  L   V            V+L+ K+V Y N LG+F++  
Sbjct: 85  ARHFGWGLADPK---PGHDWATLRDAVQGHVRSLNWGHRVQLKKKKVDYFNALGTFINKS 141

Query: 135 TLKLWHPKKGTKEITTRHVVIAVGGRPRQLACLGGEL--AVSSDDIFWMKQKEPGKTLVV 192
           +L    P    + ++  + V+AVGGRP     + G L  A++SDD+F + +K PGKTLVV
Sbjct: 142 SLSAKAPDGTEQILSASNFVVAVGGRPTLPIDVPGALEHAITSDDLFSL-EKPPGKTLVV 200

Query: 193 GASYVALECAGFLKGMGYAVKVMVRSILLRGFDQDMASKIGEYMEMQSGIEFIRKTVPQS 252
           G SYVALECAGFL G+G+ V VMVRSI LRGFDQ M+  +  +ME   G  F+   +P+ 
Sbjct: 201 GGSYVALECAGFLNGLGFDVSVMVRSICLRGFDQQMSKLVTSHME-SVGTRFLWTCLPKE 259

Query: 253 ITKLDSGQLLVKWITEDGDCFEETFDTVLNATGRDPDVAKLGLDEAGVKLNEKTGRIWVN 312
           + K   G+L V W    G   E+ FDTV+ A GR      L L+  GV+LN +  ++  +
Sbjct: 260 VKKCPDGRLQVSWTDSRGSVQEDVFDTVMFAIGRQAKTKGLNLEGVGVRLNPRNHKVVAS 319

Query: 313 N-EQTTTPNVYAIGDVIDA-PELTPVAIQAGRLLSRRLYNEGTVQMDYDKICTAVFTPIE 370
           + EQ++  N+YAIGDV+D  PELTPVAI+AG+LL+RRL      +MDYDK+ T VFTP+E
Sbjct: 320 DLEQSSVSNIYAIGDVLDGRPELTPVAIRAGKLLARRLAGVTDERMDYDKVATTVFTPLE 379

Query: 371 YGCCGLSEEDSKEEYGDDSVEVYHKNFVPLEWSLAEQTRIAAESCYVKVVCDKTRNNFVL 430
           YGC GLSEE + E +G D V+V H  + PLE+++ ++    A  CY+K V  ++ +  VL
Sbjct: 380 YGCVGLSEEAALEAHGADDVDVLHAFYKPLEYTVPQRD---ASHCYMKAVTLRSGSQPVL 436

Query: 431 GFHYLGPNAGEVTQAMGLAMKLGFTYDQLVDTVGIHP 467
           G H  GP+AGEV Q    A+K   T   L +TVGIHP
Sbjct: 437 GLHMTGPHAGEVIQGYAAALKCNLTRKVLEETVGIHP 473


  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF excluding environmental samples
  from WGS projects
    Posted date:  Mar 15, 2011  4:40 PM
  Number of letters in database: 290,268,701
  Number of sequences in database:  13,389,222
  
Lambda     K      H
   0.318    0.137 5.30e-313 

Gapped
Lambda     K      H
   0.267   0.0410 5.30e-313 

Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 13389222
Number of Hits to DB: 216679740
Number of extensions: 9210831
Number of successful extensions: 25091
Number of sequences better than 10: 446
Number of HSP's better than 10 without gapping: 0
Number of HSP's gapped: 23947
Number of HSP's successfully gapped: 524
Length of query: 493
Length of database: 4585235997
Length adjustment: 143
Effective length of query: 350
Effective length of database: 2670577251
Effective search space: 934702037850
Effective search space used: 934702037850
T: 11
A: 40
X1: 16 (7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 83 (36.6 bits)

