CLUSTAL W (1.83) multiple sequence alignment Mus ---------------------MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENE 39 Rattus ---------------------MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENE 39 Homo ---------------------MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENE 39 Pan ---------------------MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENE 39 Pongo ---------------------MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENE 39 Macaca ---------------------MEDSMDMDMSLLRPQNYLFGCELKADKDDHFKVDNDENE 39 Canis ---------------------MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENE 39 Bos ---------------------MEDSMDMDMSPLRPQNYLFGCELKADRDYHFKVDNDENE 39 Monodelphis MAAQCSFRKTSGARQRRRQSAMEDSMEMDMSPLRPQNFLFGCELKADKDYHFKVDNDENE 60 *****:**** *****:*********:* ********** Mus HQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVV 99 Rattus HQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVV 99 Homo HQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVV 99 Pan HQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVV 99 Pongo HQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVV 99 Macaca HQLSLRTISLGAGAKDELYIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGAFEITPPVV 99 Canis HQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVV 99 Bos HQLSLRTVSLGAGAKDELHVVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVV 99 Monodelphis HQLSLRTVSLGAGAKDELHIVEAEALNYEGNPIKVTLASLKMSVQPTVSLGGFEITPPVV 120 *******:**********::*****:****.*******:************.******** Mus LRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLD 159 Rattus LRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLD 159 Homo LRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLA 159 Pan LRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLA 159 Pongo LRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLA 159 Macaca LRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLA 159 Canis LRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGSGSKVPQKKVKLA 159 Bos LRLKCGSGPVHISGQHLVAVEEDAESEEEEEEEVKLLSISGKRSAPGSGSKVPQKKVKLA 159 Monodelphis LRLKCGSGPVHVSGQHLVALEEDAESDDEEEDDMKLLNMSGKRSAPGVGSKVPQKKVKLS 180 ***********:*******:******::*:*:::***.:******** *.********* Mus EDDE-DDDEDDEDDE--DDDDDDFDEEETEEKVP-VKKSVRDTPAKNAQKSNQNGKDLKP 215 Rattus EDDD-EDDEDDEDDE--DDDDDDFDEEETEEKVP-VKKSVRDTPAKNAQKSNQNGKDLKP 215 Homo ADED-DDDDDEEDDD-EDDDDDDFDDEEAEEKAP-VKKSIRDTPAKNAQKSNQNGKDSKP 216 Pan ADED-DDDDDEEDDD-EDDDDDDFDDEEAEEKAP-VKKSIRDTPAKNAQKSNQNGKDSKP 216 Pongo ADED-DDDDDDEDDDDEDDDDDDFDDEEAEEKAP-VKKSIRDTPAKNAQKSNQNGKDSKP 217 Macaca ADED-DDDDEDDDDE--DDDDDDFDDEEAEEKAP-VKKSIRDTPAKNAQKSNQNGKDSKP 215 Canis ADED-DDDDDDDDDDDEDDDDDDFDDEEAEEKAP-VKKSIRDTPAKNAQKSNQNGKDSKP 217 Bos ADEDEDDDDDDDDDDDEDDDDDDFD-EEVEEKAP-VKKSVRDTPAKNAQKSNQNGKDSKP 217 Monodelphis EEDE-EDDEEDDDDE--DDDDDDFEDEESEEKTPPVKKSVRDTAAKNAQKSNQNGKDSKP 237 ::: :**::::**: *******: ** ***.* ****:***.************* ** Mus S-TPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 274 Rattus S-TPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 274 Homo SSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 276 Pan SSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 276 Pongo SSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 277 Macaca SSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 275 Canis S-TPRTKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 276 Bos S-TPRSKGQESFKKQEKTPKTPRGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCF 276 Monodelphis S-TPKAKGQDSFKKQDKTPKTPKGPTSLEDIKAKMQASIEKGGSLPKVEGKFINYVKNCF 296 * **::***:*****:******:**:*:*********************.********** Mus RMTDQEAIQDLWQWRKSL------------------ 292 Rattus RMTDQEAIQDLWQWRKSL------------------ 292 Homo RMTDQEAIQDLWQWRKSL------------------ 294 Pan RMTDQEAIQDLWQWRKSL------------------ 294 Pongo RMTDQEAIQDLWQWRKSLYENSLNNLLKIFRLISFL 313 Macaca QMTDQEAIQDLWQWRKSL------------------ 293 Canis RMTDQEAIQDLWQWRKSL------------------ 294 Bos RMTDQEAIQDLWQWRKSL------------------ 294 Monodelphis RMSDQEAIQDLWLWRKSL------------------ 314 :*:********* *****