Estudi d'homologia del gen RARA en altres espècies
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
5 15 25 35 45 55
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ATGGCGGGCA AAGGCAACCC AGTGCCGGGC CCCCACCTCA ACGGCTTCCC TGTGCCCGCC
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
65 75 85 95 105 115
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---ATGGAAA CGGTTGAAAG TGTTGATTCA TCAGTAGATT CAAGAAGTCA CATGGAATCT
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon TACTCGTATT TCTTCCCCCA CATGCTGGGG AGCCTGTCGC CGCCGGGCCT GCCTGGTCTT
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
125 135 145 155 165 175
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes TCCCAAACTT TACAAAGGAA ATCTTCCATT GACAGCCAAG CTACAACGGC TGAAAGTCTT
CionaSavig ------ACGT ACCAGAGAAA GCCGTCGGTG GACAGCCAAT CCACCACCAC AGAGAGCAGT
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon CCCATCAGTG GGTACAGCAC TCCTTCACCG GCCAGTAAGG CCTTCTCTAC CGGGCAAAGA
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
185 195 205 215 225 235
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes GGTTCTCCTT CACCGAGAAT ATTGTTATCC CCTTCACCCC AACCTTTACC ATTCTTTCCA
CionaSavig GGTTCCCCAC CCCATGCCCT TGTATTACCA CCTTCACCAC AGCCGATGTC GTATTACCAA
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon AATGGAATTG ATACCAGTGA CTCTCCCTCT CAATCATCAG TCAAAAAAGA AGAGATAAAA
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
245 255 265 275 285 295
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes CATTATACAG CCCAG---TT TTATGGTCTT GGAACATCAG AATCTCCAAA ACATTTCAAA
CionaSavig CCCAGCACTG CACAGATGTT CCATGGACTC CGAAGGTCTG ATTCACCACA ATACA--AAG
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon GCGAGGCAGG AGAGGGACCT CTCGTCAAGC AGCTGGGCAG AGGTGAGCCA GAGTGGAGAG
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
305 315 325 335 345 355
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes TCAGCTTCAT CTGCTTCAAA CATGTCCTCT CATCCCTCTG TTTCTGCCTC GCAAAGTGA-
CionaSavig CTAGC----- -------AAC CATG------ CAGCACAAAG TAGCAAT--- ----AATGA-
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon AAGATCGCAG GAATTCGCCC CAGTTTGAAG TATTTCCAGA ATGCCGATAG CCATAATGGA
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
365 375 385 395 405 415
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes -TTACCATAA ACAGTTTATG TCCCAGGCCT TATCCATGGC AATGATGCCG CCCAGCTTCC
CionaSavig -TTATCACAA CCAACTAATG TCTCAAGCCT TGTCGATGGC GATGTTGCAA CCAGGGTTTA
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon TTTATGAGTA GGCCACACTT AGTGTGGCAG CCTGCATCTT CCCAAAGTTT CCAGCTCCGC
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
425 435 445 455 465 475
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes CACCAAGTTA TGGAATTGG- -TGGCTATAA TTCTGCA--- -GTTGACATT CAAGGTTTCT
CionaSavig CTCCAAGTTA CGCTGGTAAA TTGACTAAAC TTCCTCATCC CATAGATTTA CAAGGCTTCC
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon TGTGGGAAAA GTGGGCACAT TCATGACTCA GTGACTTTAC CGCTTTTGTT CCTGGATGTG
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
485 495 505 515 525 535
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes TAATAAGTGC TGCAGCGCAA GCAATGAGTG CTGCGTTGAA ACCTCACGCC CTGAATTCCA
CionaSavig TACTGAGTGC AGCGGCACAG GCAATGAGTG CTGCGTTGAA TCCGTGTCAA CAAAGT---A
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon TGCTGGGTGA GCAGACTGAG GAGCTTCTCT GGGCAGCGCT CGAGGAAAGG CCTAATGGTG
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
545 555 565 575 585 595
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ACAGCCCTCC CTCTGCCCAA TCCTCATGGA AGTTGCCACC TACATCGTGC ACTGCATCCC
CionaSavig AGAACCAAAC CTGCGA---- ---TAGTAGA TGGAACCAAC CTAAGTTTAA CCTCCATTCC
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- -ATGTACGAG
DarioRerio ---------- ---------- ---------- ---------- ---------- -ATGTACGAG
Takifugu ---------- ---------- ---------- ---------- ---------- -ATGTATGAG
Tetraodon CTACACCGGG TGTGGAAGTT CGCGTCCGGC TCTGGTCTCT CGCTGCGTAT GATGTACGAG
Xenopus ---------- ---------- ---------- ---------- ---------- -ATGTACGAG
Erinaceus ---------- ---------- ---------- ---------- ---------- -ATGTACGAG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
605 615 625 635 645 655
Mus ---------- -ATGGCCAGC AATAGCAGTT CCTGCCCAAC ACCTGGGGGC GGGCACCTCA
Rattus ---------- -ATGGCCAGC AATAGCAGTT CCTGCCCGAC ACCTGGGGGC GGGCACCTCA
Canis ---------- -ATGGCCAGC AACAGCAGCT CCTGCCCGAC ACCTGGGGGA GGGCACCTCA
Monodelphi ---------- -ATGGCCAGC AATAGCAGCT CTTGCCCGAC GCCTGGGGGT GGGCACCTAA
CionaIntes CTGTTGGCAA TTATCTTCAC AAATCCCATA CA-AGTTCAG GTCGAGGCGC TGATCGGC-T
CionaSavig ACACCAGTAA ATATTCAAAT ATTTATTGAG TGTAACGTGC GTCATTACCT ACGTCATT-T
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---AGGGCGC CTCTCGCCTC TCGGGGGA-T
DarioRerio AGCGTGGACG TTGTGGGACT GACCCCTAGC CCGAACCCGT TTTTAAGCAT GGATTACTAC
DarioRerio AGCGTGGACG TTGTGGGACT GACCCCTAGC CCGAACCCGT TTTTAAGCAT GGATTACTAC
Takifugu AGTGTGGACG TGGTGGGACT GAATCCCAGC CCGAACCCCT TTTTAATGAT GGAATACTAC
Tetraodon AGTGTGGACG TGGTGGGACT GAACCCCAGC CCGAATCCCT TTTTGATGAT GGAATACTAC
Xenopus AATGTGGACG TTCCTGGTTT GGGCACTAGC CCGACGCACT ACCATATGAT GGATTTCTAT
Erinaceus AGTGTGGAAG TGGGGGGGCT CACTCCCACC CCCAACCCGT TCCTGGTGGT GGATTTCTAT
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
665 675 685 695 705 715
Mus ATGGGTACCC AGTACCCCCC TACGCCTTCT TCTTTCCCCC TATGCTGGGT GGACTCTCCC
Rattus ATGGGTACCC AGTACCCCCC TACGCCTTCT TCTTCCCCCC TATGCTGGGT GGACTCTCCC
Canis ATGGCTACCC GGTGCCCCCC TACGCCTTCT TCTTCCCACC TATGCTGGGT GGACTCTCAC
Monodelphi ACGGGTACCC GGTGCCTCAC TATGCCTTCT TCTTCCCTCC CATGCTGGGC GGACTTTCTC
CionaIntes AAATGAGGTG GACTGCATGC CAAACCCATC TCATTTTAAT GGCACAGCGA --ACCATGGA
CionaSavig GTCCGCAGTT AGCCCGCCGT CGTGCG-ATC CAAGGGCAAC CAAACCAAGC --GACACAAG
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste GTACGAAAGC G--TGGATGT TGTGGC-TTT TAGCCCCAAC ----CCGAGC --AGCCCCAG
DarioRerio CACCAGAACC GCGGCTGTTT GATCCCGGAT AAAGGCCTCG TGTCGGGAGC --GGCCC---
DarioRerio CACCAGAACC GCGGCTGTTT GATCCCGGAT AAAGGCCTCG TGTCGGGAGC --GGCCC---
Takifugu AACCAGAGCA GAGGATGCTT GATCCCAGAG AAAGGACTGG TGCCCGGGGC --GCCCCATC
Tetraodon AACCAGAGCA GAGGATGCTT GATCCCAGAG AAGGGGCTGG TGCCCGGGGC --GCCCCATC
Xenopus AGCCAGAACC GGGCTTGCCT ATTGCAGGAG AAAGGACTCG GG-ACCATGC --ATCCCTA-
Erinaceus AACCAGAACC GGGCCTGTTT GCTCCCCGAG AAGGGGCTTC CCGCCTCGGG --TCCCTACT
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
725 735 745 755 765 775
Mus CACCCGGCGC TCTCACCAGC CTCCAGCACC AGCTTCCAGT CAGTGGTTAC AGCACACCGT
Rattus CACCAGGCGC TCTCACCAGC CTCCAGCATC AGCTCCCAGT TAGCGGCTAC AGCACACCGT
Canis CGCCAGGCGC GCTGACCACT CTCCAGCACC AGCTCCCAGT CAGCGGCTAT AGCACACCAT
Monodelphi CACCTGGCAC CCTGACAAGT ATCCAGCACC AGCTTCCTGT CAGTGGGTAC AGCACTCCAT
CionaIntes CAA-GAGAAT GCGAAACGGA GGAAAATGTC AGAAATGCGA GATGGAGGAC GTGAGAGAAA
CionaSavig CACCGGGCAT GCAAAGCGCA GGAAAATATC GGAT---CGT GATGGACCAC GTGATCGAAA
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste TCCCGGCTCC TTCCTGAGCA TGGAC-TACT ACCACCGCCC CCCGGGGCTC GGGCCGGAGA
DarioRerio ------GCGG GT---TCAGG AACCCTCACT GGAGCGGCTC GAATCACT-- ----------
DarioRerio ------GCGG GT---TCAGG AACCCTCACT GGAGCGGCTC GAATCACT-- ----------
Takifugu CCTACAGCAC GTCCATCAGG AACCAGCACT GGAACGGCTC CAACCACT-- ----------
Tetraodon CCTACAGCAC GTCCATCAGG AACCAGCACT GGAACGGCTC CAACCACTGT AGCAGGAGGC
Xenopus ----CGGGAC GCCACTTCGA AGTCAACACT GGAGCAGTTC CAACCACT-- ----------
Erinaceus ------CCAC CCCGCTCCGG ACTCCACTGT GGAATGGCTC TAACCACT-- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- --TCTCCTCC CGCCC--CCC CAACAGCC-- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ---GATTTTT
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- ---------- ---------- ----------
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
785 795 805 815 825 835
Mus CCCCAGCCA- ---------- ---------- ---------- ---------- ----------
Rattus CCCCAGCCA- ---------- ---------- ---------- ---------- ----------
Canis CCCCAGCCAG AATTC----- ---------- ------CAGG CAGGTGTAGC TGGGGTTCCG
Monodelphi CACCAGCCA- ---------- ---------- ---------- ---------- ----------
CionaIntes TCCCATTGAG AGCTCGGTGT CGCCTACTAG TGTTGGTCTC AACAACCACA CAGGGGAAAA
CionaSavig CCACCCGAAC GAC---GACT CGCCGACGAG TGG------- AGCGATTAC- -AGGGGACAA
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste -------AGG GGCT---GCT GTCCGGCGCG GGGGGGCTCC AGCGCCCGTT CGGAGGGTCC
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon TCCATCGCAG GCTTGCCCTG AGCTGGCCTA CTTTGGACTG TTTGATCTCA TTGTGGAACG
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ATAACCAGAA CCGGGCCTGT TTGCTCCCGG AGAAGGGGCT CCCCGCCCCC GGCCCCTACA
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca ---------- ---------- ---------- -------ATG TACGAGAGTG TAGAAGTGGG
Pan ---------- ---------- ---------- -------ATG TACGAGAGTG TAGAAGTGGG
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
845 855 865 875 885 895
Mus ---------- ---------- ---------- ---------- --CCATCGAG ACCCAGAGCA
Rattus ---------- ---------- ---------- ---------- --CCATCGAG ACCCAGAGCA
Canis GCTTTGCCAC TACTACAGAG TGGAGTCCAA GTCTTGGGTT TGCCATTGAG ACCCAGAGCA
Monodelphi ---------- ---------- ---------- ---------- --CCATTGAA ACTCAGAGCA
CionaIntes ATGTAGGGCT TCTCCCGACA GCGTCGGCCT CTCATCCACT GGCAGTAGTT ACTCTG-GTT
CionaSavig GTGCTGTGCA TCGCCCGATA GTATCGGCCT CTCATCGACT GGCAGCAGCT ATTCCG-GCT
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste CTGGTGAGCG GCCGGCACTG GAGTGGATC- --CAGCCACT --CCATAGAG ACGGAGAGCA
DarioRerio ---------- ---------- ---------- ---------- --CTGTGGAG ACCCAGAGCA
DarioRerio ---------- ---------- ---------- ---------- --CTGTGGAG ACCCAGAGCA
Takifugu ---------- ---------- ---------- ---------- --CCATAGAA ACCCAGAGCA
Tetraodon GTGAAGCGTT GGAGCCTGTG CCTAAGGCGG ATACGCAGAA GGCCATAGAA ACCCAGAGTA
Xenopus ---------- ---------- ---------- ---------- --CCATTGAG ACTCAGAGCA
Erinaceus ---------- ---------- ---------- ---------- --CTATTGAG ACCCAGAGCA
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ----ATCGAG ACCCAGAGCA
Oryctolagu ---------- ---------- ---------- ---------- ----ATTGAG ACCCAGAGCA
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus CCACCCCGCT CCGGACTCCG CTTTGGAATG GCTCAAACCA CTNNNNNNNN NNNNNNNNNN
Loxodonta ---------- ---------- ---------- ---------- ----GTTGAG ACCCAGAGCA
Macaca GGGTCCCACC CCTAACCCCT TCCTAGTGG- ---TGGATTT TTATAACCAG AACCGGGCCT
Pan GGGTCCCACC CCTAACCCCT TCCTAGTGG- ---TGGATTT TTATAACCAG AACCGGGCCT
Echinops ---------- ---------- ---------- ---------- ----ATCGAG ACCCAGAGCA
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
905 915 925 935 945 955
Mus GCAGTTCCGA AGAGAT---- --AGTACCCA GCCCTCCCTC ACCACCGCCC CTGCCCCGCA
Rattus GCAGTTCGGA AGAGAT---- --AGTGCCCA GCCCTCCCTC ACCACCACCC CTGCCTCGAA
Canis GCAGTTCCGA AGAGAT---- --AGTGCCCA GTCCTCCCTC GCCACCCCCC CTCCCCCGCA
Monodelphi GCAGTTCAGA GGAGAT---- --CGTACCCA GCCCCCCCTC ACCACCTCCT CTCCCCCGGA
CionaIntes CGGAATCCGA TGGTCTTCAC CCCGGCCAAT GTCCCCCCTC CCCACCCCCA CCACCTCGTA
CionaSavig CCGAGTCGGA CGGGATCCAT CCCGGCCAGT GCCCGCCCTC ACCGCCCCCG CCGCCCCGCA
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste CGAGTTCGGG AGAGGACCTG CTCGTCCCCA GCCCGGCCTC CCCCCCGCCT CCGCCCCGCA
DarioRerio CAAGCTCAGA GGAGAT---- --CGTACCCA GCCCTCCTTC ACCGCCACCT CCACCACGGG
DarioRerio CAAGCTCAGA GGAGAT---- --CGTACCCA GCCCTCCTTC ACCGCCACCT CCACCACGGG
Takifugu CCAGCTCGGA AGAGAT---- --AGTGCCAA GCCCACCTTC GCCTCCCCCG CCACCCCGCG
Tetraodon CCAGCTCGGA AGAGAT---- --AGTGCCAA GCCCGCCTTC GCCTCCCCCG CCGCCCCGGG
Xenopus CCAGTTCGGA GGAGAT---- --TGTGCCTA GCCCCCCATC CCCGCCGCCC CTCCCCAGAA
Erinaceus GCAGTTCAGA GGAGAT---- --CGTGCCCA GCCCCCCCTC GCCACCCCCT CTCCCCCGTA
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy CGAGTTCTGA AGAAAT---- --CGTGCCCA GCCCCCCTTC GCCGCCGCCC CTCCCCCGCA
Oryctolagu GCAGTTCGGA AGAGAT---- --AGTGCCCA GCCCTCCCTC GCCACCCCCC CTCCCCCGCA
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus NNNNNNNNNN NNNNNN---- --NNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta GCAGTTCAGA AGACAT---- --AGTGCCCA GCCCTCCCTC ACCACCCCCT CTTCCCCGTA
Macaca GTTTGCTCCC AGAGAA---- --GGGGCTCC CCGCCCCGGG TCCGTACTCC ACCCCGCTCC
Pan GTTTGCTCCC AGAGAA---- --GGGGCTCC CCGCCCCGGG TCCGTACTCC ACCCCGCTCC
Echinops GCAGCTCTGA AGACAT---- --AGTGCCTA GCCCGCCCTC GCCGCCCCCT CTGCCCCGCA
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
965 975 985 995 1005 1015
Mus TCTACAAGCC TTGCTTTGTT TGTCAAGACA AATCATCCGG CTACCACTAT GGGGTCAGCG
Rattus TCTACAAGCC TTGCTTTGTT TGTCAAGACA AGTCATCCGG CTACCACTAT GGGGTTAGCG
Canis TCTACAAGCC TTGCTTTGTC TGTCAAGACA AATCTTCAGG CTACCACTAT GGGGTCAGCG
Monodelphi TCTACAAGCC CTGTTTTGTC TGCCAGGACA AGTCCTCGGG GTATCACTAT GGGGTCAGCG
CionaIntes TATACAAACC CTGTTTTGTA TGTGGAGACA AATCATCTGG TTATCATTAC GGAGTGGCAT
CionaSavig TCTACAAACC GTGCTTTGTG TGCGGAGACA AGTCATCGGG CTATCACTAC GGCGTCGCTT
Oryzias ---------- ---------- ---------A AGTCCTCAGG GTACCACTAT GGTGTCAGCG
Gasteroste TCTACAAGCC CTGCTTCGTC TGCCAGGACA AGTCCTCAGG GTACCACTAT GGAGTCAGCG
DarioRerio TCTACAAGCC CTGTTTTGTC TGCCAGGACA AGTCCTCGGG CTACCACTAT GGAGTCAGCG
DarioRerio TCTACAAGCC CTGTTTTGTC TGCCAGGACA AGTCCTCGGG CTACCACTAT GGAGTCAGCG
Takifugu TCTACAAGCC CTGCTTTGTG TGCCAGGACA AGTCCTCAGG GTACCACTAT GGTGTCAGTG
Tetraodon TCTACAAGCC CTGCTTTGTG TGCCAGGACA AGTCCTCAGG GTACCACTAT GGTGTCAGTG
Xenopus TCTACAAACC CTGCTTTGTG TGTCAGGACA AGAGTTCTGG GTATCACTAT GGAGTCAGCG
Erinaceus TCTACAAGCC CTGCTTTGTC TGTCAGGACA AGTCCTCAGG CTACCACTAT GGGGTCAGTG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy TCTACAAGCC ATGCTTCGTG TGTCAGGACA AGTCCTCGGG CTACCACTAC GGCGTCAGCG
Oryctolagu TCTACAAGCC CTGCTTTGTC TGCCAAGACA AATCCTCTGG CTACCACTAT GGGGTCAGCG
CaviaPorce ---------- ---------- ---------- -----TCATA CCAGCACCAT GGTATTGTTG
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta TCTACAAGCC TTGCTTTGTC TGTCAAGACA AGTCCTCCGG CTACCACTAT GGGGTCAGCG
Macaca GGACTCCGCT TTGGAATGGC TCAAACCACT CCATTGAGAC CCAGAGCAGC AGTTCTGAAG
Pan GGACTCCGCT TTGGAATGGT TCAAACCACT CCATTGAGAC CCAGAGCAGC AGTTCTGAAG
Echinops TCTACAAGCC TTGCTTTGTT TGTCAAGACA AGTCCTCCGG CTACCACTAT GGGGTCAGCG
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1025 1035 1045 1055 1065 1075
Mus CCTGTGAGGG CTGTAAGGGC TTCTTCCGAC GAAGCATCCA GAAGAACATG GTGTATACGT
Rattus CCTGTGAGGG CTGTAAGGGC TTCTTCCGAC GCAGTATCCA AAAGAACATG GTGTATACGT
Canis CCTGTGAGGG CTGCAAGGGC TTCTTCCGCC GCAGCATCCA GAAGAACATG GTGTACACGT
Monodelphi CCTGTGAAGG CTGTAAGGGC TTCTTTCGTC GAAGCATCCA GAAAAACATG GTGTATACAT
CionaIntes CTTGCGAGGG TTGCAAGGGC TTCTTTCGAC GTAGTGTGCA GAAGAACATG CAGTATACTT
CionaSavig CGTGCGAAGG CTGCAAGGGC TTCTTCCGCC GCAGTGTGCA GAAGAACATG CAGTACACCT
Oryzias CCTGTGAAGG CTGCAAGGGC TTCTTTCGGA GAAGCATCCA GAAAAACATG GTGTACACTT
Gasteroste CCTGCGAGGG CTGCAAGGGT TTCTTTCGGA GAAGCATCCA AAAGAACATG GTGTACACGT
DarioRerio CATGTGAAGG GTGTAAGGGT TTTTTCCGGA GAAGCATTCA GAAGAACATG GTGTACACCT
DarioRerio CATGTGAAGG GTGTAAGGGT TTTTTCCGGA GAAGCATTCA GAAGAACATG GTGTACACCT
Takifugu CCTGTGAGGG CTGTAAGGGC TTCTTTCGGA GAAGCATCCA GAAGAACATG GTGTATACTT
Tetraodon CCTGTGAGGG CTGCAAGGGC TTCTTTCGGA GGAGCATCCA GAAGAACATG GTGTACACTT
Xenopus CTTGTGAAGG CTGTAAGGGC TTTTTCCGTC GCAGTATCCA GAAGAATATG GTGTATACAT
Erinaceus CCTGTGAGGG CTGCAAGGGC TCTCCC---- --AGCATCCA GGAGAACTT- ---TTTCACC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy CCTGCGAAGG TTGCAAGAG- ---------- --ACTAGGTA AGCATGTTC- ---TCTCCCT
Oryctolagu CCTGTGAGGG CTGCAAGGGC TTCTTCCGCC GCAGCATCCA GAAGAACATG GTGTACACGT
CaviaPorce CCTGTGAGGG CTGCACCNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta CCTGTGAGGG CTGCAAGGGC TTCTTCCGCC GCAGCATCCA GAAGAACATG GTGTACACAT
Macaca AGATAGTGCC CAGCCCTCCC TCGCCGCCCC CTCTACCCCG CATCTACAAG CCTTGCTTTG
Pan AGATAGTGCC CAGCCCTCCC TCGCCACCCC CTCTACCCCG CATCTACAAG CCTTGCTTTG
Echinops CCTGCGAGGG CTGCAAGGGC TTCTTCCGCC GCAGCATCCA GAAGAACATG GTGTACACAT
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1085 1095 1105 1115 1125 1135
Mus GTCACCGGGA CAAGAACTGC ATCATCAACA AGGTGACCCG GAACCGCTGC CAGTACTGCC
Rattus GTCACCGGGA CAAGAACTGC ATCATCAACA AGGTGACCCG GAACCGCTGC CAGTACTGCC
Canis GTCACCGGGA CAAGAACTGT ATCATCAATA AGGTGACCCG GAACCGCTGC CAGTACTGCC
Monodelphi GTCACCGGGA TAAGAACTGT ATCATCAACA AGGTGACGAG AAATCGCTGT CAGTACTGCC
CionaIntes GTCATCGTAA CAAACAATGT CTCATCAACA AGTCTACAAG GAGCCGATGT CAGTATTGCC
CionaSavig GCCACCGCAA CAAGCAATGC CTCATCAACA AATCCACTAG GAGCAGATGT CAGTTCTGCA
Oryzias GTCACCGGGA GAAGAACTGC ATCATCAACA AAGTCACCCG CAACCGCTGC CAGTACTGTC
Gasteroste GTCACCGAGA CAAAGTGTGT GTGATAAACA AGGTGACGAG GAACCGGTGC CAGTCCTGCC
DarioRerio GCCACAGAGA GAAGAGCTGT ATCATCAACA AGGTCACCCG AAACCGCTGC CAGTACTGCC
DarioRerio GCCACAGAGA GAAGAGCTGT ATCATCAACA AGGTCACCCG AAACCGCTGC CAGTACTGCC
Takifugu GTCACCGGGA GAAAAATTGC ATCATCAACA AGGTCACTCG CAACCGCTGC CAGTACTGTC
Tetraodon GTCACCGGGA GAAGAACTGC ATCATCAACA AGGTCACCCG CAACCGCTGC CAGTACTGTC
Xenopus GCCATCGAGA CAAGAACTGC ATCATAAACA AGGTGACGCG GAACCGCTGC CAGTACTGCC
Erinaceus GGTCCCCGGG CCCTGGACAC ATCTAACAAA GG--GACCGG AAACTCCTCC CGGTC---CC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy GCAGGAGAAA TTCTATCAGT GTCACTTAGG GGCTGAGCAA AGGAACAAAT GGGGA---GA
Oryctolagu GTCACCGCGA CAAGAACTGC ATCATCAACA AGGTGACCCG GAACCGCTGC CAGTACTGCC
CaviaPorce NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta GTCACCGGGA CAAGAACTGC ATCATCAACA AGGTGACCCG GAACCGCTGC CAGTACTGCC
Macaca TCTGTCAGGA CAAGTCCTCA GGCTACCACT ATGGGGTCAG CGCCTGTGAG GGCTGCAAGG
Pan TCTGTCAGGA CAAGTCCTCA GGCTACCACT ATGGGGTCAG CGCCTGTGAG GGCTGCAAGG
Echinops GTCACCGAGA CAAGAACTGC ATCATCAACA AGGTGACCCG GAACCGCTGC CAGTACTGCC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1145 1155 1165 1175 1185 1195
Mus GGCTGCAGAA ATGTTTCGAC GTGGGCATGT CCAAGGAGTC GGTGCGAAAC GATCGAAACA
Rattus GGCTGCAGAA ATGCTTCGAA GTGGGCATGT CCAAGGAGTC GGTGCGAAAC GACCGAAACA
Canis GGCTGCAGAA GTGCTTTGAA GTGGGCATGT CCAAGGAGTC TGTGAGGAAC GACAGAAACA
Monodelphi GGCTACAGAA ATGCTTTGAA GTGGGCATGT CCAAGGAGTC TGTGAGGAAC GATCGGAACA
CionaIntes GCTTGCAGAA ATGCATCCAA GCTGGGATGC TACGTGAATC GGTCAGAAAC GATCGTAACA
CionaSavig GACTCCAGAA GTGTTTCCAA GCTGGGATGC TTCGTGAATC GGTGCGGAAC GACCGCAACA
Oryzias GGTTACAGAA GTGCCTGGAA GTCGGCATGT CGAAGGAATG TGAGCAAATA AATGNTGACA
Gasteroste GGCTGCAGAA ATGCCTCGAG GTCGGCATGT CCAAAGAGCT GGTGCGAAAC GACCGCATGA
DarioRerio GACTGCAGAA GTGCCTGGAA GTGGGCATGT CTAAAGAATC TGTTAGGAAC GACCGGAACA
DarioRerio GACTGCAGAA GTGCCTGGAA GTGGGCATGT CTAAAGAATC TGTTAGGAAC GACCGGAACA
Takifugu GACTGCAGAA GTGCCTGGAA GTCGGAATGT CCAAGGAGTC TGTGAGGAAT GACCGAAACA
Tetraodon GACTGCAGAA GTGCCTGGAA GTGGGAATGT CCAAGGAGTC TGTGAGGAAT GACCGGAACA
Xenopus GGTTGCAGAA ATGTTTTGAG GTCGGCATGT CTAAAGAATC TGTACGGAAT GACCGCAACA
Erinaceus GGCTGGCAAA ATGCTTGGAA G------TGG GCTCCAAGTC TGTGAGGAAC GACCGGAACA
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy AAGGATCATG GACTATGGCC C------TAC CCCCCCAGCC -GTGCGGAAC GACCGGAACA
Oryctolagu GGCTGCAGAA GTGCTTCGAA GTGGGCATGT CCAAGGAGTC TGTGCGGAAC GACCGGAACA
CaviaPorce NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta GGCTGCAGAA ATGCTTCGAA GTGGGCATGT CGAAGGAGTC TGTGAGGAAT GACCGAAACA
Macaca GCTTCTTCCG CCGCAGCATC CAGAAGAACA TGGTGTACAC GTGTCACCGG GACAAGAACT
Pan GCTTCTTCCG CCGCAGCATC CAGAAGAACA TGGTGTACAC GTGTCACCGG GACAAGAACT
Echinops GGCTGCAGAA GTGCTTCGAA GTGGGCATGT CCAAGGAGTC GGTGCGGAAT GACCGGAACA
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1205 1215 1225 1235 1245 1255
Mus AAAA------ ---GAAGAAA GAGGCACCCA AG---CCCGA GTGCTCAGA- -GAGCTACAC
Rattus AAAA------ ---GAAGAAA GAAACACCCA AG---CCCGA GTGCTCAGA- -GAGCTACAC
Canis AGAA------ ---GAAGAAG GAGGCGCCCA AG---CCCGA GTGCTCTGA- -GAGCTACAC
Monodelphi AGAA------ ---AAAGAAA GAGACGCCCA AA---GCAGA GTGTTCAGA- -GAGCTACAC
CionaIntes AGAAGCGTGG AAAGGAAAAG GAAGGAAAGT CGGATCAGAA TGGAGTTGAC GAGCCTTCGT
CionaSavig AGAAGCGAGG CAAGGAGAAG GAGGGGAAAT CC--CCCGAG CAGAAC-GAT GACGTCACCT
Oryzias GGAA---CAA GAAGAAGAAG GATGAGAAGA AG---CAGGA GTGCACGGA- -GAGCTACGT
Gasteroste AGAA------ ---GAAGAAG GAGGACAAGA GG---CAGGG GGAGACGGA- -GATCTACGT
DarioRerio AAAG------ ---GAAGAAA GACGACAAGA AG---CAAGA ATGTTTGGA- -AAATTACGT
DarioRerio AAAG------ ---GAAGAAA GACGACAAGA AG---CAAGA ATGTTTGGA- -AAATTACGT
Takifugu AGAA------ ---GAAAAAG GACGAGAAAA AG---CCAGA GTGCATAGA- -GAACTATGT
Tetraodon AGAA------ ---GAAAAAG GATGAGAAGA AG---CCGGA GTGCATAGA- -GAACTATGT
Xenopus AGAA------ ---GAAAAAG GAGCCCCCAA AG---GCCGA CGTGATGGA- -GAGTTACGT
Erinaceus AGAA------ ---GAAGAAG GAGGTTCCCA AG---CCCGA GTGCTCTGA- -GAGTTACAC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy AGAA------ ---GAAGAAG GAACCGTCCA AG---GCCGA GTGCTCGGA- -GAGCTGCAG
Oryctolagu AGAA------ ---GAAGAAG GAGGCGCCCA AG---CCCGA GTGCTCCGA- -GAGCTACAC
CaviaPorce NNNN------ ---NNNNNNN NNNNNNNNNN NN---NNNNN NNNNNNNNN- -NNNNNNNNN
Dasypus NNNN------ ---NNNNNNN NNNNNNNNNN NN---NNNNN NNNNNNNNN- -NNNNNNNNN
Loxodonta AGAA------ ---GAAGAAG GAGGTGCCCA AG---CCCGA GTGCTCTGA- -GAGCTACAC
Macaca GCAT------ ---CATCAAC AAGGTGACCC GG---AACCG CTGCCAGTA- -CTGCCGACT
Pan GTAT------ ---CATCAAC AAGGTGACTC GG---AACCG CTGCCAGTA- -CTGCCGACT
Echinops AAAA------ ---GAAGAAG GAGGCGCCCA AG---CCCGA GTGCTCGGA- -GAACTACAC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1265 1275 1285 1295 1305 1315
Mus GCTGACGCCT GAGGTGGGCG AGCTCATTGA GAAGGTTCGC A--------- ----------
Rattus GCTGACACCG GAGGTGGGGG AACTCATCGA GAAGGTGCGC A--------- ----------
Canis GCTGACGCCC GAGGTGGGGG AGCTCATCGA GAAGGTGCGC A--------- ----------
Monodelphi ACTGACTCCT GAGGTGGAGG AGCTGATTGA GAAAGTTCGA A--------- ----------
CionaIntes GTTCA--CCT GAAATCGAAG CGTTAGTTAC ATCTGTTCAT A--------- ----------
CionaSavig GCTCG--CCT GAGATAGAAG CGCTGGTTGC ATCTGTGTAC A--------- ----------
Oryzias GCTGAGTCCC GACACGGAGC AGATGATCGA CAGGGTTCGC A--------- ----------
Gasteroste CCTGTCGGCA GACACCGAGC AGATGATCGA AGGGGTCCGC C--------- ----------
DarioRerio CTTAAGTCCA GATACGGAGA AGATGATCGA GCAGGTGAGG A--------- ----------
DarioRerio CTTAAGTCCA GATACGGAGA AGATGATCGA GCAGGTGAGG A--------- ----------
Takifugu GCTGAGTCCT GATACTGAGC AGATGATCAA CAGGGTTCGC A--------- ----------
Tetraodon GTTGAGCCCT GACACCGAGC AGATGATCAA CAGGGTTCGC A--------- ----------
Xenopus ACTGAGCCCA GAGACAGAAG ATCTCATTGA GAAAGTGCGC A--------- ----------
Erinaceus ACTGACGCCC GAGGTGGGGG AGCTCATCG- ---AGTGCGC A--------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy CCTGACGCCC GAGGTGGAGG AGCTGATCGG CAAAGTGCGC A--------- ----------
Oryctolagu GCTGACGCCG GAGGTGGGGG AGCTCATCG- ---AGTGCGC A--------- ----------
CaviaPorce NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNN--- ---------- ----------
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNN--- ---------- ----------
Loxodonta GCTGACGCCG GAGGTGGGGG AGCTCATTGA GTGCGCA--- ---------- ----------
Macaca GCAGAAGTGC TTCGAAGTGG GCATGTCCAA GGAGTCTGTG AGAAATGACC GAAACAAGAA
Pan GCAGAAGTGC TTCGAAGTGG GCATGTCCAA GGAG------ ---------- ----------
Echinops GCTGACGCCG GAGGTGGGCG AGCTCATCGA GTGCGGA--- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1325 1335 1345 1355 1365 1375
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus ---------- ---------- ---------- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ---------- ---------- ---------- ---------- ---------- ----------
Loxodonta ---------- ---------- ---------- ---------- ---------- ----------
Macaca GAAGAAGGAG GTGCCCAAGC CCGAGTGCTC CGAGAGCTAC ACGCTGACGC CGGAGGTGGG
Pan ---------- ---------- ---------- ---------- ---------- ----------
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1385 1395 1405 1415 1425 1435
Mus ---------- ---------A AGCGCACCAG GAGACCTTCC CGGCCCTCTG CCAGCTGGGC
Rattus ---------- ---------A AGCACACCAG GAGACCTTCC CGGCCCTCTG CCAGCTGGGC
Canis ---------- ---------A AGCACACCAG GAAACCTTCC CTGCACTCTG CCAGCTGGGC
Monodelphi ---------- ---------A AGCCCACCAG GAAACCTTCC CTGCCCTCTG CCAACTCGGG
CionaIntes ---------- ---------A ATTTCATGTT GAAACTTTTC CACTCAGCTC AGAATTAAAG
CionaSavig ---------- ---------A ATACCACGTT GATACCTTTC CGCTGAACTC CAATCTGCGG
Oryzias ---------- ---------A GGCACATCAG GAAACTTTCC CCTCTCTCTG CCAGCTGGGC
Gasteroste ---------- ---------G GGCCCACCAG GCAACCTTTC CCTCCCTCGG TCAGCTGGGA
DarioRerio ---------- ---------A GGCCCATCAG GAAACCTTCC CCTCGCTCTG TCAGCTGGGA
DarioRerio ---------- ---------A GGCCCATCAG GAAACCTTCC CCTCGCTCTG TCAGCTGGGA
Takifugu ---------- ---------A AGCCCATCAG GAAACTTTCC CCTCTCTCTG CCAGCTGGGC
Tetraodon ---------- ---------A GGCCCATCAG GAAACCTTCC CTTCTCTCTG CCAGCTGGGC
Xenopus ---------- ---------A AGCCCATCAG GAGACGTTCC CTGCACTGTG CCAGCTGGGC
Erinaceus ---------- ---------A AGCGCACCAG GAGACCTTCC CTGCCCTCTG CCAGCTGGGC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------A GGCTCACCAG GAGACCTTCC CTGCCCTCTG CCAACTGGGC
Oryctolagu ---------- ---------A AGCGCACCAG GAGACCTTCC CCGCCCTCTG CCAGCTGGGC
CaviaPorce ---------- ---------N NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Dasypus ---------- ---------N NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta ---------- ---------A AGCGCACCAG GAAACCTTCC CCGCCCTCTG CCAGCTGGGC
Macaca GGAGCTCATT GAGTGCGCAA AGCGCACCAG GAAACCTTCC CTGCCCTCTG CCAGCTGGGC
Pan ---------- ---------A AGCGCACCAG GAAACCTTCC CTGCCCTCTG CCAGCTG---
Echinops ---------- ---------A GGCGCACCAG GAGACCTTCC CCGCCCTCTG CCAGCTGGGC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1445 1455 1465 1475 1485 1495
Mus AAGTACACTA -CGAACAACA GCTCAGAACA ACGAGTCTCC CTG------- ----GACATT
Rattus AAGTACACTA -CGAACAACA GCTCAGAACA ACGTGTCTCT CTG------- ----GACATT
Canis AAATACACTA -CGAACAACA GCTCAGAGCA ACGTGTCTCT CTG------- ----GACATT
Monodelphi AAATACACTA -CGAACAACA GCTCGGAACA ACGGGTCTCT CTG------- ----GATATT
CionaIntes AAATATCAAA TTCCTTCCCC GCCGATTGTG AAAGACACTA GTGCGAAGA- --CGGACAGC
CionaSavig AAATACAAGA TCGCGTCTCC GGTCGCAACG ACGGAACTCG AAACGAAGAA AACCGACTCC
Oryzias AAATACACTA -CGTCTAACA GCTCAGAACG CCGCGTTTCC TTG------- ----GACATT
Gasteroste AAATACACCA -CGAGCGACA GCTCGGAGCA CCGCGTGGCT CTG------- ----GACGTC
DarioRerio AAATACACCA -CGAACAACA GCGCAGACCA CAGGGTGGCT CTG------- ----GATGTC
DarioRerio AAATACACCA -CGAACAACA GCGCAGACCA CAGGGTGGCT CTG------- ----GATGTC
Takifugu AAATACACTA -CGACAAACA GCTCAGAACG ACGTGTAGCT TTG------- ----GATGTA
Tetraodon AAATACACTA -CGACAAACA GCTCGGAGCG GCGTGTGGCT TTG------- ----GACGTG
Xenopus AAATACACTA -CAAATTTCA GCTCTGAAGA GCGGGTCTCT CTG------- ----GACATC
Erinaceus AAATACACTA -CGAACAACA GCTCAGAACA ACGTGTCTCT CTG------- ----GACATT
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy AAATACACTA -CGAACAACA GCTCGGAGCA GCGGGTGTCC CTG------- ----GACGTG
Oryctolagu AAGTACACTA -CGAACAACA GCTCAGAGCA GCGCGTCTCC CTG------- ----GACATC
CaviaPorce NNNNNNNNNN -NNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNN------- ----NNNNNN
Dasypus NNNNNNNNNN -NNAACAACA GCTCAGAACA ACGTGTCTCT CTG------- ----GACATT
Loxodonta AAATACACTA -CGNNNNNNN NNNNNNNNNN NNNNNNNNNN NNN------- ----NNNNNN
Macaca AAATACACTA -CGAACAACA GCTCAGAACA ACGTGTCTCT CTG------- ----GACATT
Pan ---TACACTA -CGAACAACA GCTCAGAACA ACGTGTCTCT CTG------- ----GACATT
Echinops AAATACACTA -CGAACAACA GCTCCGAGCA GCGTGTCTCC CTG------- ----GACATT
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1505 1515 1525 1535 1545 1555
Mus GACCTCTGGG ACAAGTTCAG TGAACTCTCC ACCAAGTGCA TCATTAAGAC TGTGGAGTTC
Rattus GACCTCTGGG ACAAGTTCAG TGAACTCTCC ACCAAGTGTA TCATTAAGAC TGTGGAGTTC
Canis GACCTCTGGG ACAAGTTCAG TGAACTCTCA ACCAAGTGCA TCATTAAGAC TGTGGAGTTC
Monodelphi GACCTCTGGG ACAAGTTCAG TGAACTCTCC ACCAAATGTA TCATCAAAAC TGTGGAGTTT
CionaIntes AACTTATGGG AGAAATTCGC TGAACTATCC ACCAAATGTA TTGTGAAGAT AGTAGAGTTC
CionaSavig AATTTGTGGG AAAAATTCGC CGAGTTGTCG ACCAAGTGCA TTGTGAAGAT CGTCGAATTT
Oryzias GACCTGTGGG ACAAGTTCAG CGAGCTCTCC ACCAAGTGCA TCATCAAGAC GGTGGAGTTT
Gasteroste AGTCTCTGGG ACAAGTTCAG CGAGTTGTCC ACCAAGTGCA TCATCAAGAC GGTGGAGTTC
DarioRerio GACCTGTGGG ACAAATTTAG CGAGCTCTCC ACCAAATGCA TCATTAAAAC AGTGGAGTTC
DarioRerio GACCTGTGGG ACAAATTTAG CGAGCTCTCC ACCAAATGCA TCATTAAAAC AGTGGAGTTC
Takifugu GACCTTTGGG ACAAGTTCAG TGAACTCTCT ACAAAGTGTA TCATAAAGAC AGTGGAGTTT
Tetraodon GACCTCTGGG ACAAGTTCAG TGAACTCTCC ACCAAGTGTA TCATAAAGAC GGTGGAGTTT
Xenopus GACCTCTGGG ACAAGTTTAG CGAGCTCTCC ACTAAATGCA TCATCAAGAC GGTGGAATTT
Erinaceus GACCTCTGGG ACAAGTTCAG TGAACTCTCC A--AAGTGTA TCATTAAGAC TGTGGAGTTC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy GACCTGTGGG ACAAGTTCAG TGAACTCTCC ACCAAGTGCA TCATCAAGAC GGTGGAGTTC
Oryctolagu GACCTCTGGG ACAAGTTCAG TGAACTCTCC A--AAGTGCA TCATCAAGAC CGTGGAGTTT
CaviaPorce NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN N--NNNNNNN NNNNNNNNNN NNNNNNNNNN
Dasypus GACCTCTGGG ACAAGTTCAG TGAACTCTCC A--AAGTGCA TCATTAAGAC TGTGGAGTTC
Loxodonta NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN N--NNNNNNN NNNNNNNNNN NNNNNNNNNN
Macaca GACCTCTGGG ACAAGTTCAG TGAACTCTCC A--AAGTGCA TCATTAAGAC TGTGGAGTTC
Pan GACCTCTGGG ACAAGTTCAG TGAACTCTCC A--AAGTGCA TCATTAAGAC TGTGGAGTTC
Echinops GACCTCTGGG ACAAGTTCAG TGAGCTCTCC A--AAGTGCA TCATTAAGAC GGTGGAATTC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1565 1575 1585 1595 1605 1615
Mus GCCAAGCAGC TTCCCGGCTT CACCACCCTC ACCATCGCCG ACCAGATCAC CCTCCTCAAG
Rattus GCCAAGCAGC TTCCCGGCTT CACCACCCTC ACCATTGCCG ACCAGATTAC CCTTCTCAAG
Canis GCCAAGCAAC TGCCCGGCTT CACCACCCTC ACCATTGCTG ACCAGATCAC CCTCCTCAAG
Monodelphi GCCAAACAGC TTCCCGGCTT TACCACTCTT ACCATTGCTG ATCAGATCAC CCTTCTTAAG
CionaIntes GCTAAGGGGA TCCCAGGGTT CCAGGACTTC ACAATAGCTG ACCAAATTAC GCTGTTGAAA
CionaSavig GCGAAGGGGG TTCCCGGATT CCAGGACTTC ACCATCGCTG ACCAGATAAC CCTGCTGAAG
Oryzias GCAAAGCAGC TGCCCGGCTT CACCACGCTC ACCATCGCTG ACCAGATCAC TCTGCTCAAG
Gasteroste GCCAAGCAGC TGCCCGGCTT CACCACGCTG ACCATCGCCG ACCAGATCAC CCTGCTCAAA
DarioRerio GCCAAGCAGT TACCCGGCTT CACCACGCTC ACCATCGCAG ATCAGATCAC CCTGTTAAAG
DarioRerio GCCAAGCAGT TACCCGGCTT CACCACGCTC ACCATCGCAG ATCAGATCAC CCTGTTAAAG
Takifugu GCGAAGCAGC TGCCTGGCTT TGTGACGCTT ACCATCGCAG ATCAGATTAC TCTACTCAAA
Tetraodon GCTAAGCAGC TGCCTGGCTT TGTGACCCTC ACCATCGCAG ATCAGATCAC TCTCCTCAAG
Xenopus GCCAAACAGT TGCCGGGATT CACCACTCTG ACCATCGCCG ACCAGATCAC CCTCCTCAAA
Erinaceus GCCAAGCAGC TGCCCGGCTT CACCACCCTC ACCATTGCTG ACCAGATCAC CCTCCTCAAG
Gallus ---------- -----GCCGT CCGCAACGAC CGCAATAAGA AGAAGAAGGA CGTGCCGAAG
Ornithorhy GCCAAGCAGC TGCCTGGCTT CACCACGCTC ACCATCGCCG ACCAGATCAC CTTGCTCAAG
Oryctolagu GCCAAGCAGC TGCCCGGCTT CACCACCCTC ACCATCGCTG ACCAGATCAC CCTCCTCAAG
CaviaPorce NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Dasypus GCCAAGCAGC TGCCCGGCTT CACCACCCTC ACCATTGCCG ACCAGATCAC CCTCCTCAAG
Loxodonta NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Macaca GCCAAGCAGC TGCCCGGCTT CACCACCCTC ACCATCGCCG ACCAGATCAC CCTCCTCAAG
Pan GCCAAGCAGC TGCCCGGCTT CACCACCCTC ACCATCGCTG ACCAGATCAC CCTCCTCAAG
Echinops GCCAAGCAGC TGCCCGGCTT CACCACCCTC ACCATTGCTG ACCAGATCAC CCTCCTCAAG
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1625 1635 1645 1655 1665 1675
Mus GCTGCCTGCC TGGATATCCT GATTCTGCGA ATCTGCACGC GGTACACGCC TGAGCAAGAC
Rattus GCTGCCTGCC TGGACATCCT GATTCTGCGA ATCTGCACGC GGTACACACC TGAGCAAGAC
Canis GCTGCCTGCC TGGACATCCT GATCCTGCGG ATCTGCACGC GGTACACGCC CGAGCAGGAC
Monodelphi GCTGCCTGCT TAGACATCCT GATTCTTCGG ATCTGCA--- GGTACACGCC AGAACAGGAC
CionaIntes TGCGCTTGCC TAGAAGTGCT GTTTCTTCGA ATTTGCTCAC GGTTTTCACC AGAGCACGAC
CionaSavig TGTGCCTGTC TCGAAGTCTT GTTTCTTCGG ATCTGTTCGC GCTTCTCGCC CGAGCAAGAC
Oryzias GCCGCCTGTC TGGACATTCT GATTCTGCGG ATCTGCACAC GCTACACGCC GGAACAGGAC
Gasteroste GCCGCCTGCC TGGACATACT GATTCTGAGG ATCTGCACCC GCTACACGCC AGACAAGGAC
DarioRerio GCCGCCTGTC TCGACATCCT GATCCTGCGA ATATGTACAC GCTACACACC CGATCAGGAC
DarioRerio GCCGCCTGTC TCGACATCCT GATCCTGCGA ATATGTACAC GCTACACACC CGATCAGGAC
Takifugu GCAGCCTGTC TGGACATCCT GATACTCCGG ATCTGTACGC GCTACACGCC AGAACAAGAC
Tetraodon GCCGCCTGTC TGGACATCCT GATACTCCGG ATCTGTACGC GCTACACGCC AGAACAGGAC
Xenopus TCCGCCTGCT TGGATATTCT TATCCTGCGA ATTTGCACAC GTTACACCCC TGATCAGGAC
Erinaceus GCTGCCTGCC TGAATATTCT GNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Gallus ACGGAGTGCT CGGAGAGT-T ACATCGTCAC CCCCGAGGTG GAGGAGCTGA TCGAGAAGGT
Ornithorhy GCCGCCTGCC TGGACATCCT GGTG------ ---------- ---------- ----------
Oryctolagu GCTGCCTGCC TGGACATCCT GATCCTGCGG ATCTGCACGC GGTACACGCC CGAGCAGGAC
CaviaPorce NNNNNNNNNN NNNNNNNNNN NATCCTGCGG ATCTGCACGC GGTACACACC CGAGCAGGAC
Dasypus GCTGCCTGCC TGGACATCCT GNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta NNNNNNNNNN NNNNNNNNNN NATCCTGCGG ATCTGCACGC GGTACACACC TGAGCAGGAC
Macaca GCTGCCTGCC TGGACATCCT GATCCTGCGG ATCTGCACGC GGTACACACC CGAGCAGGAC
Pan GCTGCCTGCC TGGACATCCT GATCCTGCGG ATCTGCACGC GGTACACGCC CGAGCAGGAC
Echinops GGTGCTTGCC TGGACATCCT GATCCTTCGG ATCTGCACGC GGTACACCCC GGAGCAGGAC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1685 1695 1705 1715 1725 1735
Mus ACAATGACCT TCTCAGATGG ACTGACCCTG AACCGGACTC AGATGCACAA CGCTGGCTTT
Rattus ACAATGACCT TCTCAGATGG ACTGACCCTG AACCGGACTC AGATGCACAA CGCTGGCTTT
Canis ACCATGACCT TCTCAGATGG GCTGACCTTG AACCGGACCC AGATGCACAA TGCCGGCTTT
Monodelphi ACAATGACCT TCTCAGATGG GCTGACCCTG AACCGGACAC AGATGCACAA TGCAGGTTTT
CionaIntes ACGATGACTT TCTCGGATGG CCTCACACTT ACACGCAAAC AAATGAGGGT GTGCGGGTTC
CionaSavig ACGATGACGT TTTCCGATGG TCTCACCCTC ACCAGGAAGC AAATGAGGGT TTGTGGCTTC
Oryzias ACCATGACCT TCTCCGACGG ACTCACGTTA AACCGGACCC AGATGCACAA CGCCGGCTTC
Gasteroste ACCATGACCT TCTCCGACGG TCTGACCCTC AACCGCACAC AGATGCACAA CGCCGGCTTC
DarioRerio ACCATGACGT TTTCAGATGG TCTGACACTG AACCGCACAC AGATGCACAA CGCCGGCTTT
DarioRerio ACCATGACGT TTTCAGATGG TCTGACACTG AACCGCACAC AGATGCACAA CGCCGGCTTT
Takifugu ACCATGACTT TCTCAGATGG TCTAACGCTA AACCGAACTC AGATGCACAA CGCAGGTTTT
Tetraodon ACCATGACGT TCTCAGATGG ACTAACGCTA AACCGAACCC AAATGCACAA CGCGGGCTTC
Xenopus ACCATGACGT TCTCAGATGG ACTAACCCTA AACCGCACGC AGATGCACAA CGCAGGGTTC
Erinaceus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Gallus CCGCAAAGCG CACCAGGAGA CGTTCCCTGC GCTGTGCCAG CTGGGCAAAT ACACCACGAA
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ACGATGACCT TCTCGGATGG ACTGACCCTG AACCGGACCC AGATGCACAA CGCTGGCTTC
CaviaPorce ACCATGACCT TCTCTGATGG GCTGACCCTG AACCGGACCC AGATGCACAA TGCTGGCTTT
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta ACAATGACCT TCTCAGACGG GCTGACCCTG AATCGGACCC AGATGCACAA TGCTGGTTTC
Macaca ACCATGACCT TCTCGGACGG GCTGACCCTG AACCGGACCC AGATGCACAA CGCTGGCTTC
Pan ACCATGACCT TCTCGGACGG GCTGACCCTG AACCGGACCC AGATGCACAA CGCTGGCTTC
Echinops ACGATGACCT TCTCGGATGG GCTGACGCTG AACCGGACGC AGATGCACAA CGCTGGCTTC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1745 1755 1765 1775 1785 1795
Mus GGCCCCCTCA CCGACTTGGT CTTTGCCTTC GCCAACCAGC TGCTGCCCCT GGAGATGGAC
Rattus GGCCCCCTCA CCGACTTGGT CTTTGCCTTC GCCAACCAGC TGCTGCCCCT GGAGATGGAC
Canis GGCCCCCTCA CAGACCTGGT CTTCGCCTTC GCCAACCAGC TGCTGCCCCT GGAGATGGAT
Monodelphi GGGCCCCTCA CCGACCTGGT CTTTGCCTTC GCCAACCAGC TGCTGCCACT GGAGATGGAT
CionaIntes GGACCAATCA CGGAACAGGT TTTCTCGTTC GCACAATCTT TGCATCCGTT GAACGCTGAC
CionaSavig GGACCAATCA CAGAGCAGGT GTTCACATTC GCCCAATCAT TGTACCCGCT CGATGCTGAC
Oryzias GGCCCGCTCA CGGACCTGGT TTTCGCTTTC GCCAACCAAC TCCTCCCTCT GGAGATGGAC
Gasteroste GGGCCGCTCA CGGACCTGGT GTTCTCCTTC GCCAACCAGC TGCTGCCGCT GGAGATGGAC
DarioRerio GGCCCTCTCA CAGATCTGGT GTTCGCTTTC GCCAACCAGC TTCTGCCTCT GGAGATGGAT
DarioRerio GGCCCTCTCA CAGATCTGGT GTTCGCTTTC GCCAACCAGC TTCTGCCTCT GGAGATGGAT
Takifugu GGTCCTCTTA CCGACCTGGT TTTTGCATTT GCGAACCAGC TCCTTCCCCT GGAGATGGAC
Tetraodon GGTCCTCTTA CCGACCTGGT GTTTGCCTTT GCGAACCAGC TCCTTCCTCT GGAGATGGAC
Xenopus GGACCCCTCA CCGACCTGGT CTTCGCCTTC GCTAACCAGC TGCTACCACT TGAAATGGAT
Erinaceus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Gallus CAACAGCTCG GAGCAGCGCG TGTCGCTGGA CATCGACCTG TGGGACAAAT TCAGCGAGCT
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu GGACCTCTCA CCGACTTGGT CTTCGCCTTC GCCAACCAGC TGCTGCCCCT GGAGATGGAC
CaviaPorce GGCCCCCTCA CCGACCTGGT CTTTGCCTTC GCCAACCAGC TGCTGCCCCT GGAGATGGAC
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
Loxodonta GGCCCCCTCA CCGACCTGGT CTTCGCCTTT GCCAACCAGC TGCTGCCCCT GGAGATGGAT
Macaca GGCCCCCTCA CCGACCTGGT CTTTGCCTTC GCCAACCAGC TGCTGCCCCT GGAGATGGAT
Pan GGCCCCCTCA CCGACCTGGT CTTTGCCTTC GCCAACCAGC TGCTGCCCCT GGAGATGGAT
Echinops GGCCCCCTCA CCGACCTGGT CTTCGCCTTT GCCAACCAGC TGCTGCCCCT GGAGATGGAC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1805 1815 1825 1835 1845 1855
Mus GATGCTGAGA CTGGACTGCT CAGTGCCATC TGCCTCATCT GTGGAGACCG ACAGGACCTG
Rattus GATGCTGAGA CCGGACTGCT CAGTGCCATC TGCCTCATCT GTGGAGACCG ACAGGACCTG
Canis GATGCTGAGA CTGGTCTTCT CAGTGCCATT TGTCTCATCT GTGGAGACCG GCAGGACCTG
Monodelphi GACGCTGAGA CTGGGCTCCT CAGTGCCATC TGCCTCATCT GTGGAGACCG GCAGGACTTG
CionaIntes GCCACAGAAA TCGGCTTGCT CAGTGCTATT TGTCTCGTAT CCGCAGATCG AGTTGACCTC
CionaSavig GCTGCTGAGA TTGGATTGTT GAGCGCGATT TGCCTCGTGT CGGCAGACCG CCCCGACCTA
Oryzias GATGCAGAGA CGGGACTGCT GAGCGCCATC TGCCTGCTGT GTGGAGATCG GCAGGACTTG
Gasteroste GACGCGGAGA CAGGGCTGCT CAGCGCCATC TGCCTGCTCT GCGGAGACCG TCAGGATCTG
DarioRerio GATGCAGAGA CTGGGCTTCT TAGCGCCATC TGTCTGCTGT GTGGAGATCG GCAGGATCTA
DarioRerio GATGCAGAGA CTGGGCTTCT TAGCGCCATC TGTCTGCTGT GTGGAGATCG GCAGGATCTA
Takifugu GATGCAGAGA CCGGACTACT CAGCGCCATC TGTTTGCTGT GTGGAGATCG TCAGGACTTG
Tetraodon GATGCAGAGA CTGGACTGCT CAGCGCCATC TGCCTGCTGT GTGGAGATCG TCAGGACTTG
Xenopus GACGCCGAGA CTGGTCTTCT GAGCGCCATC TGCCTCATCT GTGGAGACCG GCAGGACCTG
Erinaceus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNACCG GCAGGACCTG
Gallus GTCCACGAAG TGCATCATCA AGACGGTGGA GTTCGCCAAG CAGCTGCCCG GCTTCACCAC
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu GATGCCGAGA CTGGGCTGCT TAGCGCCATC TGCCTCATCT GTGGAGACCG GCAGGACCTG
CaviaPorce GATGCAGAGA CAGGGCTGCT CAGCGCTATC TGCCTCATCT GTGGAGACCG GCAGGACCTG
Dasypus NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNACCG GCAGGACCTA
Loxodonta GACGCCGAGA CTGGGCTGCT CAGTGCCATT TGCCTCATCT GTGGAGACCG GCAGGACCTG
Macaca GATGCGGAGA CGGGGCTGCT CAGCGCCATC TGCCTCATCT GCGGAGACCG TCAGGACCTG
Pan GATGCGGAGA CGGGGCTGCT CAGCGCCATC TGCCTCATCT GCGGAGACCG CCAGGACCTG
Echinops GATGCGGAGA CCGGGCTGCT CAGCGCCATT TGCCTCATCT GTGGAGACCG GCAGGACCTG
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1865 1875 1885 1895 1905 1915
Mus GAGCAGCCAG ACAAGGTGGA CATGCTGCAA GAGCCGCTGC TGGAAGCACT GAAAGTCTAC
Rattus GAGCAGCCAG ACAAGGTGGA CATGCTGCAG GAGCCGCTGT TGGAAGCACT GAAAGTCTAT
Canis GAGCAGCCAG ACAGGGTGGA CATGCTTCAA GAGCCGCTGC TGGAGGCGCT GAAGGTCTAT
Monodelphi GAGCAACCAG ACAAAGTGGA CACGCTCCAG GAGCCACTGT TGGAGGCCCT CAAGGTCTAC
CionaIntes GAGGAGCCCG ACAAAGTTGA GTTGCTGCAA GAGTCTTTGG TCGAAGGTTT GAAATATTAT
CionaSavig GAGGAGCCGG ACAAGGTGGA GATGCTACAG GAGACATTGG TGGAAGGATT GAAGTGGTAC
Oryzias GAAGAGGCAG ACAAAGTGGA CGTCCTGCAG GAGCCACTTC TGGAGGCGCT GAAGATTTAC
Gasteroste GAGGAGTCGG ACAAGGTGGA TGTTCTCCAG GAGCCGATGC TTGAAGCCTT GAAGATCTAC
DarioRerio GAGCAGTCTG ATAAGGTGGA TGAACTTCAG GAGCCCTTGC TGGAGGCCCT GAAGATCTAC
DarioRerio GAGCAGTCTG ATAAGGTGGA TGAACTTCAG GAGCCCTTGC TGGAGGCCCT GAAGATCTAC
Takifugu GAACAGGCAG AGAAGGTGGA CATCCTACAG GAGCCTCTGC TGGAGGCACT GAAGATCTAT
Tetraodon GAACAGGCGG AGAAGGTGGA CGTCCTACAG GAGCCTCTCC TGGAGGCACT GAAGATATAC
Xenopus GAGCAGCCAG ATAAAGTGGA CAAGCTGCAG GAGCCCCTTT TGGAAGCATT GAAGATCTAT
Erinaceus GAGCAGCCAG ACAGAGTGGA CATGCTGCAG GAGCCATTGC TGGAGGCGCT GAAGGTCTAT
Gallus GCTC------ ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu GAGCAGCCAG ACAGGGTGGA CATGCTGCAC GAGCCGCTGC TCGAGGCGCT GAAGGTGTAC
CaviaPorce GAGCAGCCAG AGCGCGTGGA CCTGCTGCAG GAGCCGCTGC TGGAAGCTCT GAAGGTCTAC
Dasypus GAACAACCAG ACAGGGTGGA CATGCTACAG GAGCCGCTAC TCGAGGCGCT GAAGGTCTAC
Loxodonta GAGCAGCCAG AAAGAGTGGA CATGCTGCAG GAGCCACTGC TGGAGGCGCT GAAGGTCTAT
Macaca GAGCAGCCTG ACCGTGTGGA CATGCTGCAG GAGCCGCTGC TGGAGGCGCT AAAGGTCTAC
Pan GAGCAGCCGG ACCGGGTGGA CATGCTGCAG GAGCCGCTGC TGGAGGCGCT AAAGGTCTAC
Echinops GAGCAGCCGG ACAGAGTGGA CCTGCTGCAG GAGCCACTGC TGGAGGCACT GAAGGTCTAC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1925 1935 1945 1955 1965 1975
Mus GTCCGGAAAC GGAGGCCCAG CCGACCCCAC ATGTTCCCCA AGATGCTGAT GAAGATCACA
Rattus GTCCGGAAAC GGAGGCCCAG CCGACCCCAC ATGTTCCCCA AGATGCTGAT GAAGATCACG
Canis GTGCGGAAAC GGAGGCCCAG CCGCCCCCAC ATGTTCCCCA AGATGCTGAT GAAGATCACA
Monodelphi GTGAGGAAAC GGCGGCCCAG CCGGCCTCAC ATGTTCCCCA AAATGCTTAT GAAGATCACA
CionaIntes GCTCGGAAAA GAAGGCCGCA CACGCCACAA GTTTTTCCAA AACTTATAAT TAAAATCTCA
CionaSavig GCCCGCAAGC GACGACCCAA CGCCCCCCAA GTCTTCCCCA AACTTATCAT CAAAATATCC
Oryzias GTGAGGAAGA GAAGGCCCCA CAAACCGCAC ATGTTCCCCA AG-------- ----------
Gasteroste GTGAGGAGGA GGAGGCCCGA AAAACCTTGC ATGTTTCCCA AGATACTGAT GAAGATTACT
DarioRerio GTGAGAAATC GGAGACCTCA TAAACCACAC ATGTTCCCTA AGATGCTGAT GAAGATCACA
DarioRerio GTGAGAAATC GGAGACCTCA TAAACCACAC ATGTTTCCTA AGATGCTGAT GAAGATCACA
Takifugu GTAAGAAGGA GGAGGCCTCA CAAACCCCAC ATGTTCCCCA AGATGCTGAT GAAGATCACT
Tetraodon GTAAGGAGGA GGAGGCCTCA CAAACCCCAC ATGTTCCCCA AGATGTTGAT GAAGATCACT
Xenopus GTCAGGAACA GGCGACCCAA AAAGCCACAC ATGCTACCCG CACCCCTACT AAGGCTAGCA
Erinaceus GTGCGGAAAC GGAGGCCCAG CCGACCCCAC ATGTTCCCCA AGATGCTCAT GAAGATCACG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu GTGCGGAAGC GGAGACCCAG CCGCCCCCAC ATGTTCCCCA AGATGCTGAT GACGATCACC
CaviaPorce GTGAGGAAGC GCAGGCCCAG CCGCCCCCAC ATGTTCCCCA AGATGCTCAT GAAGATCACA
Dasypus GTGCGGAAGC GGAGGCCCAG CCGCCCCCAC ATGTTCCCCA AGATGCTGAT GAAGATCACA
Loxodonta GTGCGGAAAC GGAGGCCCAG CCGCCCGCAC ATGTTCCCCA AGATGCTGAT GAAGATCACA
Macaca GTGCGAAAGC GGAGGCCCAG CCGCCCCCAC ATGTTCCCCA AGATGCTGAT GAAGATCACT
Pan GTGCGGAAGC GGAGGCCCAG CCGCCCCCAC ATGTTCCCCA AGATGCTAAT GAAGATTACT
Echinops GTGCGGAAAC GGAGGCCCAG CCGGCCCCAC ATGTTCCCCA AGATGCTGAT GAAGATCACA
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
1985 1995 2005 2015 2025 2035
Mus GACCTTCGGA GCATCAGCGC CAAGGG---A GCTGAACGGG TGATCACATT GAAGATGGAG
Rattus GACCTTCGGA GTATCAGCGC CAAGGG---A GCTGAACGGG TGATCACATT GAAGATGGAG
Canis GACCTGCGAA GCATCAGTGC AAAGGG---G GCTGAGCGGG TGATCACGCT GAAGATGGAG
Monodelphi GACCTTCGAA GCATTAGCGC CAAGGG---A GCTGAGCGAG TGATCACGCT GAAGATGGAA
CionaIntes GACCTTCGAA GCATCAGCTT GAAAGG---C GCTGACAGAG TAGTAACTGT AAAAACCGAG
CionaSavig GATCTGCGGA GCATCAGTTT GAAAGG---A GCCGACCGCG TGGTGTCAGT AAAGAGCGAG
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste GACCTCAGGA GCATCAGTGT GAAGGGTGGA GCAGAGCGAG TGATCACGCT GAAGATGGAA
DarioRerio GACCTGAGGA GCATCAGCGC TAAAGG---A GCGGAGCGAG TAATAACGCT GAAAATGGAG
DarioRerio GACCTGAGGA GCATCAGCGC TAAAGG---A GCGGAGCGAG TAATAACGCT GAAAATGGAG
Takifugu GATCTAAGAA GCATCAGCGC TAAAGG---A GCTGAGCGAG TCATCACTCT GAAGATGGAG
Tetraodon GATCTGAGAA GCATCAGCGC TAAAGG---A GCCGAGCGAG TCATCACTCT GAAGATGGAG
Xenopus CTCTTAAGTT CTGCTCTTTG TCTCGCAGGT GCGGAGCGCG TCATCACTCT GAAGATGGAA
Erinaceus GACCTTCGAA GCATCAGTGC TAAGGG---A GCAGAGCGGG TAATCACATT GAAAATGGAG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu GACCTGCGGA GCATCAGCGC CATG------ ---------- ---------- ----------
CaviaPorce GACCTGCGCA GCATCAGCGC CAAGGG---C GCCGAGCGCG TGATCACGCT GAAGATGGAG
Dasypus GACCTGAGAA GCATCAGCGC CAAAGG---G GCCGAGCGGG TGATCACGCT GAAGATGGAG
Loxodonta GACCTGCGAA GCATCAGTGC TAAGGG---G GCTGAGCGGG TGATCACGCT GAAGATGGAG
Macaca GACCTGCGAA GCATCAGCGC CAAGGG---G GCTGAGCGGG TGATCACGCT GAAGATGGAG
Pan GACCTGCGAA GCATCAGCGC CAAGGG---G GCTGAGCGGG TGATCACGCT GAAGATGGAG
Echinops GACCTGCGAA GCATCAGCGC CAAGGG---A GCTGAGCGGG TGATCACGCT GAAGATGGAG
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2045 2055 2065 2075 2085 2095
Mus ATCCC---AG GCTCCATGCC ACCGCTGATC CAGGAAATGC TGGAGAACTC TGAGGGCTTG
Rattus ATCCC---TG GTTCCATGCC ACCACTTATC CAGGAAATGT TGGAGAACTC TGAGGGCTTG
Canis ATCCC---GG GCTCCATGCC ACCTCTCATC CAGGAAATGC TGGAGAACTC CGAGGGCCTG
Monodelphi ATCCC---GG GCTCCATGCC ACCCCTCATC CAGGAGATGC TGGAGAATTC CGAGGGCCTG
CionaIntes ATTCCGTGCG GAGCCATGCC ACCCCTTATG TCCGAGATGT TGGAAAAC-- -GACGAGGTC
CionaSavig ATCCCGTCAG GCGCGATGCC ACCACTCATG TCCGAGATGT TGGAAGGC-- -GACGAGACG
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ATACC---CG GCTCAATGCC GCCTCTCATC CAGGAAATGC TGGAGAACTC TGAGGGGCTG
DarioRerio ATCCC---AG GCTCCATGCC TCCGCTCATT CAGGAGATGC TGGAAAATTC AGAGGGTCTG
DarioRerio ATCCC---AG GCTCCATGCC TCCGCTCATT CAGGAGATGC TGGAAAATTC AGAGGGTCTG
Takifugu ATCCC---AG GCTCCATGCC TCCTCTCATC CAGGAGATGT TGGAGAACTC TGAAGGTCTG
Tetraodon ATCCC---AG GCTCCATGCC CCCCCTCATC CAGGAGATGC TGGAGAACTC GGAAGGTCTG
Xenopus ATCCC---AG GTTCCATGCC TCCCCTCATC CAGGAGATGT TGGAGAACTC AGAAGGGTTG
Erinaceus ATCCC---GG GCTCCATGCC ACCTCTCATC CAGGAAATGC TGGAGAACTC AGAGGGCCTG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ATCCC---GG GTTCCATGCC GCCGCTCATC CAGGAGATGC TGGAGAACTC CGAGGGCTTG
Dasypus ATCCC---GG GCTCCATGCC ACCGCTCATC CAGGAGATGC TGGAGAACTC AGAGGGCCTG
Loxodonta ATCCC---AG GCTCCATGCC ACCTCTCATC CAGGAGATGC TGGAGAACTC AGAGGGCCTG
Macaca ATCCC---GG GCTCCATGCC GCCTCTCATC CAGGAAATGC TGGAGAACTC AGAGGGCCTG
Pan ATCCC---GG GCTCCATGCC GCCTCTCATC CAGGAAATGT TGGAGAACTC AGAGGGCCTG
Echinops ATCCC---GG GCTCCATGCC GCCGCTCATC CAGGAAATGC TGGAGAACTC CGAGGGCCTG
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2105 2115 2125 2135 2145 2155
Mus GACACTCTAA GCGGACAGTC GGGGGGCGGA ACACGAGATG GGGGTGG--- ---CCTGGCC
Rattus GACACTCTAA GCGGACAGTC GGGGGGCGGA ACACGAGATG GGGGTGG--- ---CCTGGCC
Canis GACACTCTGA GTGGACAACC GGGGGGCGGG GGGCGGGATG GGGGCGG--- ---CCTGGCC
Monodelphi GACACTCTGA GTGGACAGCC AGGGGGCGGG GGGAGGGAAG GGAGCGGGAG CAGCCTGGCC
CionaIntes GAA------- ---------- ---------- ---------- ---------- ----------
CionaSavig GATTGA---- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste GAGGGGCATG GAGCCGGGGG AGGGAAAGGA GCAGGAGGAG GGAAAGGTTG ---CGCCGGA
DarioRerio GAGGGAGGCG GGTCGAAAGG AGCTGGAGGA GGTGGTGGTG GTGGTGGTGG ---AAAGGGA
DarioRerio GAGGGAGGCG GGTCGAAAGG AGCTGGAGGA GGTGGTGGTG GTGGTGGTGG ---AAAGGGA
Takifugu GAGAGCGG-- ---------- TGCTACAGGC AGCCGGCCCA GTGGTG---- ----------
Tetraodon GAGAGTGG-- ---------- AGCCTCAGGC AGCCGGCCCA GCGGTG---- ----------
Xenopus GACACATT-- ----GGGGGG GGGAGGAGGG GCATCCGGAG GGGCACCGCC ---CACACCA
Erinaceus GACACTCTGA GCGGACAGTC GGGGGGTGGG GGGCGGGATG GGGGCGG--- -------CAT
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce GACACTCTGA ACGGACAGTC GGGGGTCGGC GGGCGGGAC- -----GGGGG ----AGGCCT
Dasypus GACACTCTGG GCGGACAGTC GGGGGGCGGG GGCCGGGAT- -----GGGGG ----TGGCCT
Loxodonta GACACTCTGA GTGGACAGCC GGGGGGCAGG GGGCGGGACC GAGACGGGGG ----TGGCCT
Macaca GACACTCTGA GCGGACAGCC GGGGGGCGGG GGGCGGGAC- -----GGGAG ----TGGGCC
Pan GACACTCTGA GCGGACAGCC GGGGGGTGGG GGGCGGGAC- -----GGGGG ----TGGCCT
Echinops GACACTCTCA GCGGACAGCA GGGGGGCAGG GCACGGGAC- -----GGGGG ----CAGCTT
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2165 2175 2185 2195 2205 2215
Mus CCCCCTCCGG GTAGCTGTAG CCCCAGCCTC AGTCCCAGCT CCCACAGAAG CAGCCCAGCC
Rattus CCTCCTCCGG GTAGCTGTAG CCCCAGCCTC AGTCCCAGCT CCCACAGAAG CAGCCCAGCC
Canis CCCCCACCCG GCAGCTGTAG CCCTAGCCTC AGCCCCAGCT CAAACAGAAG CAGCCCGGCC
Monodelphi CCGCCCCCGG GCAGCTGCAG CCCCAGCCTC TCTCCCAGCT CCAACAGAAG CAGCCCGGCC
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste GGCACAGAAG AGGACGAATC AGAGCTCGGA AGCCGCCGTC AGAGTCCGTC GCCGGAGTCT
DarioRerio GCTCCACCAG GAAGCTGCAG CCCCAGTTTG TCTCCCAGTT CGGCACACAG CAGCCCCTCG
DarioRerio GCTCCACCAG GAAGCTGCAG CCCCAGTTTG TCTCCCAGTT CGGCACACAG CAGCCCCTCG
Takifugu -CACCCCCAG GCAGCTGCAG CCCCAGTCTG TCCCCCAGCT CGGCCCAAAG CAGTCCACCC
Tetraodon -CCCCCCCAG GCAGCTGCAG CCCCAGCCTG TCCCCGAGCT CTGCCCAAAG CAGTCCACCC
Xenopus GTACCACCAA GGAGCTGCAG TCCCAGCCTG TCACCCAGTT CCACTCACAG CAGCCCCTCT
Erinaceus GCCCCACCTG GCAGCTGCAG TCCCAGCCTC AGCCCCAGCT CTAACAGAAG CAGCCCAGCC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce GCCCCGCCAG GCATCTGTA- ---------- ---------- ---------- ----------
Dasypus GCCCCTCCAG GCAGCTGTAG CCCCAGCCTC AGCCCCAGCT CCAACAGAAG CAGCCCGGCC
Loxodonta GCCCCGCCAG GCAGCTGTAG CCCCAGTCTC AGCCCTAGCT CAAACAGAAG CAGCCCGGCC
Macaca CCCCCGCCCG GCAGCTGTAG CCCCAGCCTC AGCCCCAGCT CCAACAGAAG CAGCCCGGCC
Pan GCCCCGCCAG GCAGCTGTAG CCCCAGCCTC AGCCCCAGCT CCAACAGAAG CAGCCCGGCC
Echinops GCTCCACCGG GCAGCTGCAG CCCCAGCCTC AGCCCCAGCT CCAACAGAAG CAGCCCGGCC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2225 2235 2245 2255 2265 2275
Mus ACCCAATCCC CATGA----- ---------- ---------- ---------- ----------
Rattus ACTCAATCCC CATGA----- ---------- ---------- ---------- ----------
Canis ACCCACTCCC CGTGA----- ---------- ---------- ---------- ----------
Monodelphi ACCCATTCCC CCTGA----- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste GCT------- ---------- ---------- ---------- ---------- ----------
DarioRerio GCTCACTCTC CTTGA----- ---------- ---------- ---------- ----------
DarioRerio GCTCACTCTC CTTGA----- ---------- ---------- ---------- ----------
Takifugu ACACAATCAC CGTAG----- ---------- ---------- ---------- ----------
Tetraodon ACACAATCAC CATAG----- ---------- ---------- ---------- ----------
Xenopus ACACACTCCC CCTGA----- ---------- ---------- ---------- ----------
Erinaceus ACCCACTCCC CGTGACTGCT GTGGCGTGGA CTCTGCCCTT GCCCCAAGCA CTGGCTTTTC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ACCCACTCTC CATGACCGCC TGCGCCCCAT GGACACAGTC CTCGCCCCAA ACCCCGGCTT
Loxodonta ACCCACTCCC CATGACCACC TATGCCCCAT GGACACAGTT CGTGCCT--- GCCCTGGCTT
Macaca ACCCACTCCC CGTGACCGCC CGCGCCACAT GGACACAACC CTCGCCCTCC GCCCCGGCTT
Pan ACCCACTCCC CGTGACCGCC CACGCCACAT GGACACAGCC CTCGCCTTCC GCCCTGGCTT
Echinops ACCCATTCAC CATGACCGCC CG-------- ---------- ---GCCCTGG GCCCCGGCTT
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2285 2295 2305 2315 2325 2335
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus TCTGCCTTTA TACCAACCAT GCCACCCCCC AGCCCTGCCC CCACCTACTC TTCCCTCCTG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus TTCTCTGCCT ATCTACCAAC CAGACCCCCC AGCCCTGCCC CTACCT---- --GTCTTTGC
Loxodonta TTCTCTGCCT TTCTACCAAC CATGTCACCC CCTGCCAGCC CTGCCCCCG- --GTCCTCCC
Macaca TTCTCTGCCT TTCTACCGAC CATGTGACCC C---CCAGCC CTGCCCCCAC CTGTGCTCCC
Pan TTCTCTGCCT TTCTACCGAC CATGTGACCC CGCACCAGCC CTGCCCCCAC CTGTCCTCCC
Echinops TTTTCTGCCT TTCTACCGAC CAAGTGGACC C---TCAGCC CTGCCTCCA- --GTGCCCCC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2345 2355 2365 2375 2385 2395
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus GGGGGGAAGG GAGGAGGCAG CGATCTGGAC GGAGGCCTGG TGCGGTGGAC TGCTTGCTCC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus AGACAGAACC GGGGACTTTC CCCTGGGGGA CAGGAGGGAG GAGGCGGCGA CTCTTCGGAC
Loxodonta AGACAGAACC AGGGACCTTC CCTGGGGGGC TGGAGAGAGG GAGGCTGCAA CTCTTCAGAC
Macaca GGGCAGCACT GGGGACCTTC CCTGGGGGAC GGGGAGGGAG GAGGCAGCAA CTCCTTGGAC
Pan GGGCAGTACT GGGGACCTTC CCTGGGGGAC GGGGAGGGAG GAGGCAGCGA CTCCTTGGAC
Echinops GGACAGAACC ---GACCTTC CCTGGGGGCT ------GGAG GAGGCTGCGA CTCGGCGGGC
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2405 2415 2425 2435 2445 2455
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus TGCCTGGGCT GACGTCGCCG GCGGCCATGA GTGGAGTGAG GCCCCTGGTC CTGCGCCTTG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus AGAGGCCGGG GCTTGCGACG GACTGCCCGC CCCTGCAGCC TGCGCTGGCG TC---GGGCC
Loxodonta AGAGGCCTGG GC---CGATG GACTGACCGC TCCTGCTGCC GCTGACTTCA GG---GGGCA
Macaca AGAGGCCTGG GTCCTCAGTG GACTGCCTGC TCCCACAGCC TGGGCTGACG TCAGAGGCCG
Pan AGAGGCCTGG GCCCTCAGTG GACTGCCTGC TCCCACAGCC TGGGCTGACG TCAGAGGCCG
Echinops AGTAGCCGGG GG---CTGCG GACTGAGCAC TCCTGCTGCC TCGGCTGAC- -----GGGGG
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2465 2475 2485 2495 2505 2515
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus GGATGGGGCC TGGGGGCCTC GTGTTCATCA AGACACCCCT CTGCCCGCCT CGCCACACCT
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus AGGCGGTGGA CTGAGTGAGG ACCCCGGCCC TGGCCTTCGG GGGGGGCGCC TGCAGCCTCA
Loxodonta AGGCAGTGAA CTGAGTGAGA CCCCCTGTCC TGGGCCTCGG GATGGGGCCT GGGGGCCTCG
Macaca AGGCCGGGAA CTGAGTGAG- --CCTGGTCC CGGGTCTCAG GATGGGT--- GGGGGCCTCG
Pan AGGCCGGGAA CTGAGTGAGG CCCCTGGTCC TGGGTCTCAG AATGGGTCCT GGGGGCCTCG
Echinops TGATGGTGAA CTGAGTGAG- ---------- -CAGCCTCAG GATGGGGCCT GGGGGCCTTG
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2525 2535 2545 2555 2565 2575
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus TCATCACCAG CAAACGCCAG GACCTGGCTC CCCCATCCTC AGAACTTGCA AGCCATTGCC
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus C---CATCAC GACGCCCCTC TGCCCACCTT GCCACATCTT CATCACCAGC AAATGCCAGG
Loxodonta T---GTTCAA GACACCCCTC TACCCATCTC GCCACATCTT CATCACCAGC AAATGCCAGG
Macaca TGTTCATCAG GACACCCCTC TGCCCAGCTC ACCACATCTT CATCACCAGC AAATGCCAGG
Pan TGTTCATCAA GACACCCCTC TGCCCAGCTC ACCACATCTT CATCACCAGC AAACGCCAGG
Echinops T---GTTCAA GATGCC---- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2585 2595 2605 2615 2625 2635
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus CCCTGGTTGG GGACCCCCCC TGCCTTGGTT GGTGACAGAG GGGGTGGGCC AGGGGTGGGG
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ACCTGGCTCC CCCAGCCTCA GAACTCACAA GCCATTGCTC CCCAACTGGG GA---CC---
Loxodonta AACTGGCTCC CCCATCCTCA GAACTCATAA GCCATTGCTC CCCAGTTGGG GGACCCT---
Macaca ACTTGGCTCC CCCATCCTCA GAACTCACAA GCCATTGCTC CCCAGCTGGG GAACCTCAGC
Pan ACTTGGCTCC CCCATCCTCA GAACTCACAA GCCATTGCTC CCCAGCCGGG GAACCTCAAC
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2645 2655 2665 2675 2685 2695
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus TGGGGGGGCT CCCCCTGTAC ATACCCTGCC ATACCAACCC CAGATTCTCG CTGGTTTTGT
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus CTCCCCCCTG CCTTGGTTGG TGGGGCCAGG GGTGGG---- --GGTGGGGG TTCCTCCTGT
Loxodonta CTCCCCCCTG CCTTGGTTGG TGACAGAGGG GGTGGGCCAG AGGTGGGGAG TTCCCCCTGT
Macaca CTCCCCCCTG CCTTGGTTGG TGACAGAGGG GGTGGGACAG GGGCGGGGGG TTCCCCCTGT
Pan CTCCCCCCTG CCTCGGTTGG TGACAGAGGG GGTGGGACAG GGGCGGGGGG TTCCCCCTGT
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ....|....| ....|....| ....|....| ....|....| ....|....|
2705 2715 2725 2735 2745 2755
Mus ---------- ---------- ---------- ---------- ---------- ----------
Rattus ---------- ---------- ---------- ---------- ---------- ----------
Canis ---------- ---------- ---------- ---------- ---------- ----------
Monodelphi ---------- ---------- ---------- ---------- ---------- ----------
CionaIntes ---------- ---------- ---------- ---------- ---------- ----------
CionaSavig ---------- ---------- ---------- ---------- ---------- ----------
Oryzias ---------- ---------- ---------- ---------- ---------- ----------
Gasteroste ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
DarioRerio ---------- ---------- ---------- ---------- ---------- ----------
Takifugu ---------- ---------- ---------- ---------- ---------- ----------
Tetraodon ---------- ---------- ---------- ---------- ---------- ----------
Xenopus ---------- ---------- ---------- ---------- ---------- ----------
Erinaceus TTTTATTTTA ATTTTTTTGT TTTGA----- ---------- ---------- ----------
Gallus ---------- ---------- ---------- ---------- ---------- ----------
Ornithorhy ---------- ---------- ---------- ---------- ---------- ----------
Oryctolagu ---------- ---------- ---------- ---------- ---------- ----------
CaviaPorce ---------- ---------- ---------- ---------- ---------- ----------
Dasypus ACATACCCCG CCATACCAAC CCCAGATTCT TGCTGGTTTT GTTTTAATTT TAATTTTTTT
Loxodonta TCATACCCTG TCGTACCAAC CCCAAGTATT AATTCTCGCT GGTT---TTT TAATTTTTTT
Macaca ACATACCCTG CCGTACCAAC CCCAGGTATT AATTCTCGCT GGTTTTGTTT TTATTTTAAT
Pan ACATACCCTG CCATACCAAC CCCAGGTATT AATTCTCGCT GGTTTTGTTT TTATTTTAAT
Echinops ---------- ---------- ---------- ---------- ---------- ----------
....|....| ...
2765
Mus ---------- ---
Rattus ---------- ---
Canis ---------- ---
Monodelphi ---------- ---
CionaIntes ---------- ---
CionaSavig ---------- ---
Oryzias ---------- ---
Gasteroste ---------- ---
DarioRerio ---------- ---
DarioRerio ---------- ---
Takifugu ---------- ---
Tetraodon ---------- ---
Xenopus ---------- ---
Erinaceus ---------- ---
Gallus ---------- ---
Ornithorhy ---------- ---
Oryctolagu ---------- ---
CaviaPorce ---------- ---
Dasypus TTTTTGGTTT TGA
Loxodonta GTTTTGG--- ---
Macaca TTTTTTGGTT ---
Pan TTTTTTGTTT TGA
Echinops ---------- ---