TRANSFAC FACTOR TABLE, Release 7.0 - public - 2005-09-30, (C) Biobase GmbH

This version of the TRANSFAC database is free for users from non-profit organizations only.
Users from commercial organizations have to license the TRANSFAC databases and accompanying programs.
TRANSFAC FACTOR TABLE, Release 7.0 - public - 2005-09-30, (C) Biobase GmbH


AC   T00386
XX
ID   T00386
XX
DT   15.10.1992 (created); ewi.
DT   09.03.1998 (updated); tme.
CO   Copyright (C), Biobase GmbH.
XX
FA   HSTF
XX
SY   dHSF (Drosophila heat shock factor); HAP; heat shock transcription factor; HSF; HSTF.
XX
OS   fruit fly, Drosophila melanogaster
OC   eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
CL   3.4.1.0.4.
XX
SZ   691 AA; 76.9 kDa (cDNA)
XX
SQ   MSRSRSSAKAVQFKHESEEEEEDEEEQLPSRRMHSYGDAAAIGSGVPAFLAKLWRLVDDA
SQ   DTNRLICWTKDGQSFVIQNQAQFAKELLPLNYKHNNMASFIRQLNMYGFHKITSIDNGGL
SQ   RFDRDEIEFSHPFFKRNSPFLLDQIKRKISNNKNGDDKGVLKPEAMSKILTDVKVMRGRQ
SQ   DNLDSRFSAMKQENEVLWREIASLRQKHAKQQQIVNKLIQFLITIVQPSRNMSGVKRHVQ
SQ   LMINNTPEIDRARTTSETESESGGGPVIHELREELLDEVMNPSPAGYTAASHYDQESVSP
SQ   PAVERPRSNMSISSHNVDYSNQSVEDLLLQGNGTAGGNILVGGAASPMAQSVSQSPAQHD
SQ   VYTVTEAPDSHVQEVPNSPPYYEEQNVLTTPMVREQEQQKRQQLKENNKLRRQAGDVILD
SQ   AGDILVDSSSPKAQRTSIQHSTQPDVMVQPMIIKSEPENSSGLMDLMTPANDLYSVNFIS
SQ   EDMPTDIFEDALLPDGVEEAAKLDQQQKFGQSTVSSGKFASNFDVPTNSTLLDANQASTS
SQ   KAAAKAQASEEEGMAVAKYSGAENGNNRDTNNSQLLRMASVDELHGHLESMQDELETLKD
SQ   LLRGDGVAIDQNMLMGLFNDSDLMDNYGLSFPNDSISSEKKAPSGSELISYQPMYDLSDI
SQ   LDTDDGNNDQEASRRQMQTQSSVLNTPRHEL
XX
SC   SwissProt #P22813
XX
FT       33    163      winged helix homology (weak) [1].
FT       45    148      SM00415; HSF.
FT       46    150      DNA binding Domain [2].
FT       47    241      PF00447; HSF_DNA-bind.
FT      579    610      hydrophobic repeat.



XX
SF   asymmetric molecular shape of the monomer, even higher asymmetry found for the trimer [5];
XX
FF   cooperative DNA-binding to multiple elements (HSE) after trimerization [4] [5] [9];
FF   inducing signals cause a transition from the inactive monomeric to the active trimeric state [5];
XX
IN   T01264 HST; yeast, Kluyveromyces lactis.
XX
MX   M00028 I$HSF_01.
MX   M00163 I$HSF_02.
MX   M00164 I$HSF_03.
MX   M00165 I$HSF_04.
MX   M00166 I$HSF_05.
XX
BS   R00751 DROME$HSP70_01; Quality: 6; hsp70, G000109; fruit fly, Drosophila melanogaster.
BS   R00752 DROME$HSP70_02; Quality: 6; hsp70, G000109; fruit fly, Drosophila melanogaster.
BS   R00753 DROME$HSP70_03; Quality: 6; hsp70, G000109; fruit fly, Drosophila melanogaster.
BS   R00754 DROME$HSP70_04; Quality: 6; hsp70, G000109; fruit fly, Drosophila melanogaster.
BS   R00755 DROME$HSP70_05; Quality: 6; hsp70, G000109; fruit fly, Drosophila melanogaster.
BS   R00756 DROME$HSP70_06; Quality: 4; hsp70, G000109; fruit fly, Drosophila melanogaster.
BS   R00773 DROME$HSP83_01; Quality: 6; hsp83, G000110; fruit fly, Drosophila melanogaster.
BS   R00762 HS$HSP70_03; Quality: 6; hsp70, G000286; human, Homo sapiens.
BS   R00775 Y$HSP83_03; Quality: 2; hsp83, G000935; yeast, Saccharomyces cerevisiae.
BS   R00776 Y$HSP83_04; Quality: 2; hsp83, G000935; yeast, Saccharomyces cerevisiae.
XX
DR   TRANSPATH: MO000045953.
DR   EMBL: M60070; DMHSPHEX.
DR   SWISSPROT: P22813; HSF_DROME.
DR   PIR: A36295; A36295.
DR   FLYBASE: FBgn0001222; Hsf.
DR   PDB: 1hks.
DR   PDB: 1hkt.
XX
RN   [1]; RE0006687.
RX   PUBMED: 8286326.
RA   Vuister G. W., Kim S.-J., Wu C., Bax A.
RT   NMR Evidence for Similarities between the DNA-Binding Regions of Drosophila melanogaster Heat Shock Factor AND Helix-Turn-Helix and HNF-3/forkhead Families of Transcription Factors
RL   Biochemistry 33:10-16 (1994).
RN   [2]; RE0006688.
RX   PUBMED: 7634100.
RA   Vuister G. W., Kim S.-J., Orosz A., Marquardt J., Wu C., Bax A.
RT   Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor
RL   Nat. Struct. Biol. 1:605-614 (1994).
RN   [3]; RE0001702.
RX   PUBMED: 8423799.
RA   Gallo G. J., Prentice H., Kingston R. E.
RT   Heat shock factor is required for growth at normal temperatures in the fission yeast Schizosaccharomyces pombe
RL   Mol. Cell. Biol. 13:749-761 (1993).
RN   [4]; RE0005280.
RX   PUBMED: 8421783.
RA   Rabindran S. K., Haroun R. I., Clos J., Wisniewski J., Wu C.
RT   Regulation of heat shock factor trimer formation: role of a conserved leucine zipper
RL   Science 259:230-234 (1993).
RN   [5]; RE0005284.
RX   PUBMED: 8497263.
RA   Westwood J. T., Wu C.
RT   Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition
RL   Mol. Cell. Biol. 13:3481-3486 (1993).
RN   [6]; RE0000209.
RX   PUBMED: 1899357.
RA   Xiao H., Perisic O., Lis J. T.
RT   Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit
RL   Cell 64:585-593 (1991).
RN   [7]; RE0000154.
RX   PUBMED: 2590940.
RA   Perisic O., Xiao H., Lis J. T.
RT   Stable Binding of Drosophila Heat Shock Factor to Head-to-Head and Tail-to-Tail Repeats of a Conserved 5 bp Recognition Unit
RL   Cell 59:797-806 (1989).
RN   [8]; RE0000082.
RX   PUBMED: 3100052.
RA   Wiederrecht G., Shuey D. J., Kibbe W. A., Parker C. S.
RT   The Saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties
RL   Cell 48:507-515 (1987).
RN   [9]; RE0000850.
RX   PUBMED: 3711119.
RA   Shuey D. J., Parker C. S.
RT   Binding of Drosophila Heat-Shock Gene Transcription Factor to the hsp 70 Promoter
RL   J. Biol. Chem. 261:7934-7940 (1986).
RN   [10]; RE0000081.
RX   PUBMED: 4028160.
RA   Topol J., Ruden D. M., Parker C. S.
RT   Sequences required for in vitro transcriptional activation of a Drosophila hsp 70 gene
RL   Cell 42:527-537 (1985).
RN   [11]; RE0001792.
RX   PUBMED: 6325944.
RA   Wu C.
RT   Two protein-binding sites in chromatin implicated in the activation of heat-shock genes
RL   Nature 309:229-234 (1984).
XX
//
This version of the TRANSFAC database is free for users from non-profit organizations only.
Users from commercial organizations have to license the TRANSFAC databases and accompanying programs.