BLASTP 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman 
(1997), "Gapped BLAST and PSI-BLAST: a new generation of 
protein database search programs", Nucleic Acids Res. 25:3389-3402.

RID: 1142614792-18728-71940883066.BLASTQ1


Database: Non-redundant SwissProt sequences
           192,555 sequences; 71,789,538 total letters
 
If you have any problems or questions with the results of this search 
please refer to the BLAST FAQs
Taxonomy reports


Query=  apo2_4|geneid_v1.2_predicted_protein_4|1392_AA
Length=1391

                                                                   Score     E
Sequences producing significant alignments:                        (Bits)  Value

gi|113992|sp|P02647|APOA1_HUMAN  Apolipoprotein A-I precursor ...   473    2e-133  
gi|59798973|sp|Q9H0K1|SN1L2_HUMAN  Serine/threonine-protein ki...   385    8e-107  
gi|59803093|sp|P57059|SN1L1_HUMAN  Serine/threonine-protein ki...   348    7e-96 
gi|62510922|sp|Q7KZI7|MARK2_HUMAN  Serine/threonine-protein ki...   336    3e-92   
gi|62510939|sp|Q9P0L2|MARK1_HUMAN  Serine/threonine-protein ki...   332    5e-91   
gi|29840797|sp|Q96L34|MARK4_HUMAN  MAP/microtubule affinity-re...   332    8e-91   
gi|29337165|sp|P27448|MARK3_HUMAN  MAP/microtubule affinity-re...   322    5e-88   
gi|34395849|sp|Q8IWQ3|BRSK2_HUMAN  BR serine/threonine-protein...   253    3e-67   
gi|34395684|sp|Q8TDC3|BRSK1_HUMAN  BR serine/threonine-protein ki   253    4e-67   
gi|20178276|sp|P54646|AAPK2_HUMAN  5'-AMP-activated protein ki...   237    3e-62   
gi|78099208|sp|Q13131|AAPK1_HUMAN  5'-AMP-activated protein ki...   233    4e-61 
gi|14424095|sp|O60285|NUAK1_HUMAN  NUAK family, SNF1-like kinase    220    4e-57   
gi|50400857|sp|Q14680|MELK_HUMAN  Maternal embryonic leucine z...   199    7e-51   
gi|30316282|sp|Q9BXA7|TSSK1_HUMAN  Testis-specific serine/thre...   182    1e-45   
gi|9973393|sp|P57058|HUNK_HUMAN  Hormonally up-regulated neu t...   172    1e-42   
gi|30316269|sp|Q96PF2|TSSK2_HUMAN  Testis-specific serine/thre...   162    9e-40   
gi|2499586|sp|Q16566|KCC4_HUMAN  Calcium/calmodulin-dependent ...   161    2e-39   
gi|30316270|sp|Q96PN8|TSSK3_HUMAN  Testis-specific serine/thre...   160    3e-39   
gi|27805738|sp|Q9UQB9|AURKC_HUMAN  Serine/threonine-protein ki...   155    8e-38   
gi|3122301|sp|Q14012|KCC1A_HUMAN  Calcium/calmodulin-dependent...   150    3e-36   
gi|67466915|sp|Q6P2M8|KCC1B_HUMAN  Calcium/calmodulin-dependen...   147    2e-35   
gi|56404610|sp|Q8IU85|KCC1D_HUMAN  Calcium/calmodulin-dependen...   147    4e-35   
gi|62287888|sp|Q6SA08|TSSK4_HUMAN  Testis-specific serine/thre...   146    5e-35   
gi|38605718|sp|P53355|DAPK1_HUMAN  Death-associated protein kinas   144    3e-34   
gi|27805737|sp|Q96GD4|AURKB_HUMAN  Serine/threonine-protein ki...   143    6e-34   
gi|27923855|sp|O14965|STK6_HUMAN  Serine/threonine-protein kin...   143    6e-34   
gi|74759724|sp|Q8IYT8|ULK2_HUMAN  Serine/threonine-protein kinase   138    1e-32   
gi|6685284|sp|O96017|CHK2_HUMAN  Serine/threonine-protein kinase    138    2e-32   
gi|2833281|sp|Q16816|PHKG1_HUMAN  Phosphorylase b kinase gamma...   137    2e-32   
gi|125536|sp|P15735|PHKG2_HUMAN  Phosphorylase b kinase gamma ...   137    2e-32   
gi|17379144|sp|P11801|KPSH1_HUMAN  Serine/threonine-protein kinas   137    3e-32   
gi|7531055|sp|O14757|CHK1_HUMAN  Serine/threonine-protein kinase    137    3e-32   
gi|6136124|sp|O75385|ULK1_HUMAN  Serine/threonine-protein kinase    137    4e-32   
gi|51316189|sp|O00444|PLK4_HUMAN  Serine/threonine-protein kin...   136    5e-32   
gi|73620970|sp|Q96NX5|KCC1G_HUMAN  Calcium/calmodulin-dependen...   136    7e-32 
gi|74762688|sp|Q96QS6|KPSH2_HUMAN  Serine/threonine-protein kinas   135    9e-32   
gi|38604691|sp|O43293|DAPK3_HUMAN  Death-associated protein ki...   135    9e-32   
gi|6225242|sp|O15075|DCAK1_HUMAN  Serine/threonine-protein kin...   134    2e-31   
gi|1170703|sp|P31751|AKT2_HUMAN  RAC-beta serine/threonine-pro...   134    2e-31   
gi|20177970|sp|Q9UQM7|KCC2A_HUMAN  Calcium/calmodulin-dependen...   134    3e-31   
gi|37999482|sp|O75582|KS6A5_HUMAN  Ribosomal protein S6 kinase...   133    4e-31   
gi|62512173|sp|Q13555|KCC2G_HUMAN  Calcium/calmodulin-dependen...   132    8e-31 
gi|12643414|sp|Q13557|KCC2D_HUMAN  Calcium/calmodulin-dependen...   132    1e-30   
gi|11133131|sp|Q9UK32|KS6A6_HUMAN  Ribosomal protein S6 kinase...   131    2e-30   
gi|12643413|sp|Q13554|KCC2B_HUMAN  Calcium/calmodulin-dependen...   131    2e-30   
gi|38605084|sp|Q9UIK4|DAPK2_HUMAN  Death-associated protein ki...   131    2e-30   
gi|1709648|sp|P51817|PRKX_HUMAN  Serine/threonine-protein kinase    129    6e-30   
gi|14423930|sp|Q9UEE5|ST17A_HUMAN  Serine/threonine-protein ki...   129    8e-30   
gi|59797954|sp|Q8N568|DCAK2_HUMAN  Serine/threonine-protein ki...   128    1e-29   
gi|68067736|sp|Q05513|KPCZ_HUMAN  Protein kinase C zeta type (nPK   128    2e-29 
gi|12643943|sp|Q9Y243|AKT3_HUMAN  RAC-gamma serine/threonine-p...   127    2e-29   
gi|33860173|sp|P22612|KAPCG_HUMAN  cAMP-dependent protein kina...   127    3e-29   
gi|125210|sp|P22694|KAPCB_HUMAN  cAMP-dependent protein kinase...   127    3e-29   
gi|1730070|sp|P51812|KS6A3_HUMAN  Ribosomal protein S6 kinase ...   125    9e-29   
gi|41017453|sp|O43930|PRKY_HUMAN  Serine/threonine-protein kinase   125    2e-28   
gi|125205|sp|P17612|KAPCA_HUMAN  cAMP-dependent protein kinase...   124    2e-28   
gi|60391226|sp|P31749|AKT1_HUMAN  RAC-alpha serine/threonine-p...   124    3e-28 
gi|37999483|sp|O75676|KS6A4_HUMAN  Ribosomal protein S6 kinase...   124    3e-28   
gi|51338822|sp|Q9H4B4|PLK3_HUMAN  Serine/threonine-protein kin...   124    4e-28   
gi|1170688|sp|P41743|KPCI_HUMAN  Protein kinase C iota type (n...   123    6e-28   
gi|20178306|sp|Q15418|KS6A1_HUMAN  Ribosomal protein S6 kinase...   122    8e-28   
gi|27735175|sp|O14936|CSKP_HUMAN  Peripheral plasma membrane p...   121    2e-27   
gi|1346538|sp|P49137|MAPK2_HUMAN  MAP kinase-activated protein...   120    3e-27   
gi|41017502|sp|Q96RG2|PASK_HUMAN  PAS domain-containing serine...   120    4e-27   
gi|6226833|sp|Q13237|KGP2_HUMAN  cGMP-dependent protein kinase...   119    7e-27   
gi|6166243|sp|Q15349|KS6A2_HUMAN  Ribosomal protein S6 kinase ...   119    9e-27   
gi|74762148|sp|Q16644|MAPK3_HUMAN  MAP kinase-activated protei...   119    1e-26   
gi|22096374|sp|Q9NYY3|PLK2_HUMAN  Serine/threonine-protein kin...   117    3e-26   
gi|34098463|sp|Q86SG6|NEK8_HUMAN  Serine/threonine-protein kin...   116    6e-26   
gi|28558166|sp|Q9HBY8|SGK2_HUMAN  Serine/threonine-protein kin...   115    1e-25   
gi|462455|sp|P05129|KPCG_HUMAN  Protein kinase C gamma type (PKC-   115    1e-25   
gi|400135|sp|Q02156|KPCE_HUMAN  Protein kinase C epsilon type (nP   115    1e-25   
gi|1346393|sp|P24723|KPCL_HUMAN  Protein kinase C eta type (nPKC-   115    1e-25   
gi|3024670|sp|Q15831|STK11_HUMAN  Serine/threonine-protein kin...   113    5e-25   
gi|125549|sp|P17252|KPCA_HUMAN  Protein kinase C alpha type (PKC-   113    6e-25   
gi|56404656|sp|Q96RR4|KKCC2_HUMAN  Calcium/calmodulin-dependen...   112    8e-25   
gi|1709658|sp|P53350|PLK1_HUMAN  Serine/threonine-protein kina...   111    2e-24   
gi|125379|sp|P14619|KGP1B_HUMAN  cGMP-dependent protein kinase...   110    4e-24   
gi|6225588|sp|Q13976|KGP1A_HUMAN  cGMP-dependent protein kinas...   110    4e-24   
gi|24211884|sp|Q9H1R3|MYLK2_HUMAN  Myosin light chain kinase 2, s   110    5e-24   
gi|1709252|sp|P51955|NEK2_HUMAN  Serine/threonine-protein kina...   110    5e-24   
gi|20138711|sp|Q9BZL6|KPCD2_HUMAN  Protein kinase D2 (nPKC-D2)      110    5e-24   
gi|12644418|sp|Q15746|MYLK_HUMAN  Myosin light chain kinase, s...   109    7e-24   
gi|20141488|sp|P05771|KPCB_HUMAN  Protein kinase C beta type (PKC   109    7e-24   
gi|3914977|sp|O00141|SGK1_HUMAN  Serine/threonine-protein kina...   108    1e-23   
gi|22256934|sp|Q96PY6|NEK1_HUMAN  Serine/threonine-protein kin...   108    1e-23   
gi|2499575|sp|Q15139|KPCD1_HUMAN  Protein kinase D1 (nPKC-D1) ...   108    2e-23   
gi|17380162|sp|O15530|PDPK1_HUMAN  3-phosphoinositide-dependent p   107    3e-23   
gi|56404620|sp|Q8N5S9|KKCC1_HUMAN  Calcium/calmodulin-dependen...   106    6e-23   
gi|82592942|sp|O60307|MAST3_HUMAN  Microtubule-associated serine/   106    8e-23 
gi|12643872|sp|Q9UBS0|KS6B2_HUMAN  Ribosomal protein S6 kinase...   105    1e-22   
gi|52000829|sp|Q8IW41|MAPK5_HUMAN  MAP kinase-activated protei...   105    1e-22   
gi|12230239|sp|O94806|KPCD3_HUMAN  Protein kinase D3 (Protein ...   105    2e-22   
gi|74762208|sp|Q5MAI5|CDKL4_HUMAN  Cyclin-dependent kinase-like 4   104    2e-22   
gi|28558163|sp|Q96BR1|SGK3_HUMAN  Serine/threonine-protein kin...   104    3e-22   
gi|20141582|sp|Q04759|KPCT_HUMAN  Protein kinase C theta type (nP   104    3e-22   
gi|38502964|sp|Q86V86|PIM3_HUMAN  Serine/threonine-protein kinase   103    5e-22   
gi|60390226|sp|Q9Y2H9|MAST1_HUMAN  Microtubule-associated seri...   103    5e-22   
gi|54041234|sp|P23443|KS6B1_HUMAN  Ribosomal protein S6 kinase...   103    6e-22   
gi|82654922|sp|Q00532|CDKL1_HUMAN  Cyclin-dependent kinase-lik...   102    8e-22 
gi|3041712|sp|Q13177|PAK2_HUMAN  Serine/threonine-protein kina...   102    1e-21   
gi|83305339|sp|P11309|PIM1_HUMAN  Proto-oncogene serine/threonine   102    1e-21 
gi|6225859|sp|Q16513|PKN2_HUMAN  Protein kinase N2 (Protein ki...   101    2e-21   
gi|547803|sp|Q05655|KPCD_HUMAN  Protein kinase C delta type (nPKC   101    2e-21   
gi|14423909|sp|O94768|ST17B_HUMAN  Serine/threonine-protein ki...   101    2e-21   
gi|62287152|sp|Q6P0Q8|MAST2_HUMAN  Microtubule-associated serine/   100    3e-21   
gi|47605999|sp|Q13464|ROCK1_HUMAN  Rho-associated protein kina...   100    5e-21   
gi|20139243|sp|Q9P1W9|PIM2_HUMAN  Serine/threonine-protein kinase   100    5e-21   
gi|8928460|sp|O75962|TRIO_HUMAN  Triple functional domain protein  99.8    7e-21   
gi|74749130|sp|Q6P5Z2|PKN3_HUMAN  Protein kinase N3 (Protein k...  99.4    9e-21   
gi|6174910|sp|Q16512|PKN1_HUMAN  Protein kinase N1 (Protein ki...  98.6    2e-20   
gi|20178297|sp|P51956|NEK3_HUMAN  Serine/threonine-protein kin...  98.2    2e-20   
gi|2499643|sp|Q13153|PAK1_HUMAN  Serine/threonine-protein kina...  97.8    3e-20   
gi|47117818|sp|O75914|PAK3_HUMAN  Serine/threonine-protein kin...  97.8    3e-20   
gi|30316125|sp|Q9HBH9|MKNK2_HUMAN  MAP kinase-interacting seri...  97.8    3e-20   
gi|74762639|sp|Q92772|CDKL2_HUMAN  Cyclin-dependent kinase-lik...  97.4    4e-20   
gi|13626607|sp|Q9Y6E0|STK24_HUMAN  Serine/threonine-protein ki...  97.1    5e-20   
gi|73621232|sp|Q9P289|MST4_HUMAN  Serine/threonine-protein kin...  96.7    6e-20   
gi|1705489|sp|P51813|BMX_HUMAN  Cytoplasmic tyrosine-protein k...  95.9    1e-19   
gi|47605963|sp|O75116|ROCK2_HUMAN  Rho-associated protein kina...  95.5    1e-19   
gi|12585288|sp|O96013|PAK4_HUMAN  Serine/threonine-protein kin...  95.5    1e-19   
gi|2499640|sp|Q99759|M3K3_HUMAN  Mitogen-activated protein kin...  95.1    2e-19   
gi|6685620|sp|Q9Y2U5|M3K2_HUMAN  Mitogen-activated protein kin...  94.7    2e-19   
gi|12643529|sp|O00506|STK25_HUMAN  Serine/threonine-protein ki...  94.4    3e-19   
gi|73621340|sp|O95747|OXSR1_HUMAN  Serine/threonine-protein ki...  94.4    3e-19   
gi|6175070|sp|O76039|CDKL5_HUMAN  Cyclin-dependent kinase-like...  93.6    5e-19   
gi|12585290|sp|Q9P286|PAK7_HUMAN  Serine/threonine-protein kin...  93.6    5e-19   
gi|74715639|sp|Q8NG66|NEK11_HUMAN  Serine/threonine-protein ki...  92.8    9e-19   
gi|34098605|sp|Q8TD19|NEK9_HUMAN  Serine/threonine-protein kin...  92.4    1e-18   
gi|74762479|sp|Q8IVW4|CDKL3_HUMAN  Cyclin-dependent kinase-lik...  92.4    1e-18   
gi|231726|sp|Q00526|CDK3_HUMAN  Cell division protein kinase 3     92.0    1e-18   
gi|74746874|sp|Q5VT25|MRCKA_HUMAN  Serine/threonine-protein ki...  92.0    1e-18   
gi|3915762|sp|P53667|LIMK1_HUMAN  LIM domain kinase 1 (LIMK-1)     91.3    3e-18   
gi|74762299|sp|Q6DT37|MRCKG_HUMAN  Serine/threonine-protein ki...  90.1    6e-18   
gi|23396789|sp|Q9NQU5|PAK6_HUMAN  Serine/threonine-protein kin...  89.4    1e-17   
gi|2833269|sp|Q15835|RK_HUMAN  Rhodopsin kinase precursor (RK)...  89.0    1e-17   
gi|1708824|sp|P53671|LIMK2_HUMAN  LIM domain kinase 2 (LIMK-2)     89.0    1e-17   
gi|46396051|sp|Q9Y2A5|DUET_HUMAN  Serine/threonine-protein kin...  89.0    1e-17   
gi|125480|sp|P07948|LYN_HUMAN  Tyrosine-protein kinase Lyn         88.6    2e-17   
gi|115922|sp|P06493|CDC2_HUMAN  Cell division control protein ...  88.6    2e-17   
gi|12643880|sp|Q9UEW8|STK39_HUMAN  STE20/SPS1-related proline-...  88.6    2e-17   
gi|56749668|sp|Q9Y2H1|ST38L_HUMAN  Serine/threonine-protein ki...  88.2    2e-17   
gi|4033704|sp|Q00535|CDK5_HUMAN  Cell division protein kinase ...  87.8    3e-17   
gi|1709347|sp|P51957|NEK4_HUMAN  Serine/threonine-protein kina...  87.4    4e-17   
gi|116051|sp|P24941|CDK2_HUMAN  Cell division protein kinase 2 (p  87.4    4e-17   
gi|74762068|sp|Q9Y5S2|MRCKB_HUMAN  Serine/threonine-protein ki...  87.0    5e-17   
gi|83305929|sp|Q96RU8|TRIB1_HUMAN  Tribbles homolog 1 (TRB-1) ...  86.7    6e-17   
gi|14285498|sp|O15111|IKKA_HUMAN  Inhibitor of nuclear factor ...  86.3    8e-17   
gi|462203|sp|P34947|GRK5_HUMAN  G protein-coupled receptor kin...  86.3    8e-17   
gi|30316115|sp|Q9BUB5|MKNK1_HUMAN  MAP kinase-interacting seri...  85.9    1e-16   
gi|85700366|sp|P45984|MK09_HUMAN  Mitogen-activated protein ki...  85.5    1e-16 
gi|20141386|sp|P43250|GRK6_HUMAN  G protein-coupled receptor k...  85.1    2e-16   
gi|125474|sp|P06239|LCK_HUMAN  Proto-oncogene tyrosine-protein...  85.1    2e-16   
gi|57015279|sp|O14578|CTRO_HUMAN  Citron Rho-interacting kinas...  85.1    2e-16   
gi|114006|sp|P06727|APOA4_HUMAN  Apolipoprotein A-IV precursor (A  85.1    2e-16   
gi|125351|sp|P16591|FER_HUMAN  Proto-oncogene tyrosine-protein ki  84.0    4e-16   
gi|1169745|sp|P42685|FRK_HUMAN  Tyrosine-protein kinase FRK (N...  84.0    4e-16   
gi|2507195|sp|P45983|MK08_HUMAN  Mitogen-activated protein kin...  83.6    5e-16   
gi|34222826|sp|Q86UE8|TLK2_HUMAN  Serine/threonine-protein kin...  83.2    7e-16   
gi|56749457|sp|Q15208|STK38_HUMAN  Serine/threonine-protein ki...  82.8    9e-16   
gi|19857975|sp|P29322|EPHA8_HUMAN  Ephrin type-A receptor 8 pr...  82.4    1e-15   
gi|85681908|sp|P00519|ABL1_HUMAN  Proto-oncogene tyrosine-prot...  82.4    1e-15 
gi|74759739|sp|Q8IZL9|CCRK_HUMAN  Cell cycle-related kinase (C...  82.4    1e-15   
gi|12643825|sp|Q9NYV4|CD2L7_HUMAN  Cell division cycle 2-relat...  82.4    1e-15   
gi|8928302|sp|Q13882|PTK6_HUMAN  Tyrosine-protein kinase 6 (Br...  82.0    2e-15   
gi|1351326|sp|P42681|TXK_HUMAN  Tyrosine-protein kinase TXK        82.0    2e-15   
gi|12643358|sp|O94804|STK10_HUMAN  Serine/threonine-protein kinas  82.0    2e-15   
gi|125711|sp|P12931|SRC_HUMAN  Proto-oncogene tyrosine-protein...  81.6    2e-15   
gi|1168268|sp|P42684|ABL2_HUMAN  Tyrosine-protein kinase ABL2 ...  81.6    2e-15   
gi|34223086|sp|Q9UKI8|TLK1_HUMAN  Serine/threonine-protein kin...  81.3    3e-15   
gi|74762638|sp|Q92519|TRIB2_HUMAN  Tribbles homolog 2 (TRB-2)      81.3    3e-15   
gi|585361|sp|Q08881|ITK_HUMAN  Tyrosine-protein kinase ITK/TSK...  81.3    3e-15   
gi|20178302|sp|Q07002|PCTK3_HUMAN  Serine/threonine-protein ki...  81.3    3e-15   
gi|8488988|sp|Q13233|M3K1_HUMAN  Mitogen-activated protein kin...  80.9    3e-15   
gi|1730068|sp|P10398|ARAF_HUMAN  A-Raf proto-oncogene serine/t...  80.9    3e-15   
gi|400274|sp|Q02750|MP2K1_HUMAN  Dual specificity mitogen-acti...  80.9    3e-15   
gi|20141296|sp|P08631|HCK_HUMAN  Tyrosine-protein kinase HCK (...  80.9    3e-15   
gi|266425|sp|Q00536|PCTK1_HUMAN  Serine/threonine-protein kina...  80.5    4e-15   
gi|14285497|sp|O14920|IKKB_HUMAN  Inhibitor of nuclear factor ...  80.5    4e-15   
gi|50403720|sp|P15056|BRAF1_HUMAN  B-Raf proto-oncogene serine...  80.5    4e-15   
gi|68052263|sp|O43283|M3K13_HUMAN  Mitogen-activated protein k...  80.5    4e-15   
gi|27805732|sp|Q9H3Y6|SRMS_HUMAN  Tyrosine-protein kinase Srms     80.5    4e-15   
gi|59803097|sp|Q00537|PCTK2_HUMAN  Serine/threonine-protein ki...  80.1    6e-15 
gi|46577700|sp|Q13188|STK3_HUMAN  Serine/threonine-protein kin...  79.7    8e-15   
gi|2507196|sp|P53779|MK10_HUMAN  Mitogen-activated protein kin...  79.7    8e-15   
gi|125370|sp|P06241|FYN_HUMAN  Proto-oncogene tyrosine-protein...  79.7    8e-15   
gi|37537965|sp|Q8TDX7|NEK7_HUMAN  Serine/threonine-protein kin...  79.7    8e-15   
gi|41688789|sp|Q96J92|WNK4_HUMAN  Serine/threonine-protein kin...  79.7    8e-15   
gi|13124559|sp|Q13043|STK4_HUMAN  Serine/threonine-protein kin...  79.3    1e-14   
gi|50400798|sp|Q9UBE8|NLK_HUMAN  Serine/threonine kinase NLK (Nem  79.3    1e-14   
gi|1174630|sp|P42680|TEC_HUMAN  Tyrosine-protein kinase Tec        79.3    1e-14   
gi|41688799|sp|Q9Y3S1|WNK2_HUMAN  Serine/threonine-protein kin...  79.3    1e-14   
gi|6685621|sp|Q9Y6R4|M3K4_HUMAN  Mitogen-activated protein kin...  79.0    1e-14   
gi|125651|sp|P04049|RAF1_HUMAN  RAF proto-oncogene serine/thre...  79.0    1e-14   
gi|125870|sp|P07947|YES_HUMAN  Proto-oncogene tyrosine-protein ki  79.0    1e-14   
gi|68067660|sp|P50750|CDK9_HUMAN  Cell division protein kinase...  79.0    1e-14 
gi|1706450|sp|Q09013|DMPK_HUMAN  Myotonin-protein kinase (Myot...  79.0    1e-14   
gi|1705485|sp|P51451|BLK_HUMAN  Tyrosine-protein kinase BLK (B ly  78.2    2e-14   
gi|66774048|sp|Q14004|CD2L5_HUMAN  Cell division cycle 2-like ...  78.2    2e-14 
gi|41688792|sp|Q9BYP7|WNK3_HUMAN  Serine/threonine-protein kin...  77.8    3e-14   
gi|41688795|sp|Q9H4A3|WNK1_HUMAN  Serine/threonine-protein kin...  77.8    3e-14   
gi|74761996|sp|Q9UL54|TAOK2_HUMAN  Serine/threonine-protein ki...  76.6    6e-14   
gi|2499600|sp|Q16539|MK14_HUMAN  Mitogen-activated protein kin...  76.6    6e-14   
gi|37537993|sp|Q9HC98|NEK6_HUMAN  Serine/threonine-protein kin...  76.3    8e-14   
gi|3183518|sp|Q05397|FAK1_HUMAN  Focal adhesion kinase 1 (FADK...  76.3    8e-14   
gi|125358|sp|P09769|FGR_HUMAN  Proto-oncogene tyrosine-protein ki  76.3    8e-14   
gi|2851522|sp|P53778|MK12_HUMAN  Mitogen-activated protein kin...  76.3    8e-14   
gi|729887|sp|P41240|CSK_HUMAN  Tyrosine-protein kinase CSK (C-...  76.3    8e-14   
gi|547759|sp|Q06187|BTK_HUMAN  Tyrosine-protein kinase BTK (Br...  76.3    8e-14   
gi|78099183|sp|Q9H2K8|TAOK3_HUMAN  Serine/threonine-protein ki...  75.9    1e-13   
gi|125387|sp|P29320|EPHA3_HUMAN  Ephrin type-A receptor 3 prec...  75.5    1e-13   
gi|543848|sp|P35626|ARBK2_HUMAN  Beta-adrenergic receptor kina...  74.7    2e-13   
gi|1706628|sp|P54756|EPHA5_HUMAN  Ephrin type-A receptor 5 pre...  74.3    3e-13   
gi|74759012|sp|Q7L7X3|TAOK1_HUMAN  Serine/threonine-protein ki...  74.3    3e-13   
gi|2499633|sp|Q13163|MP2K5_HUMAN  Dual specificity mitogen-act...  74.3    3e-13   
gi|71153819|sp|Q16584|M3K11_HUMAN  Mitogen-activated protein k...  74.3    3e-13   
gi|18202489|sp|Q12852|M3K12_HUMAN  Mitogen-activated protein k...  73.9    4e-13   
gi|120049|sp|P21802|FGFR2_HUMAN  Fibroblast growth factor rece...  73.9    4e-13   
gi|232066|sp|P27361|MK03_HUMAN  Mitogen-activated protein kina...  73.6    5e-13   
gi|399448|sp|P31152|MK04_HUMAN  Mitogen-activated protein kina...  73.6    5e-13   
gi|29427834|sp|Q8N4C8|MINK1_HUMAN  Misshapen-like kinase 1 (Mi...  73.2    7e-13   
gi|120046|sp|P11362|FGFR1_HUMAN  Basic fibroblast growth facto...  73.2    7e-13   
gi|547915|sp|P36507|MP2K2_HUMAN  Dual specificity mitogen-acti...  72.8    9e-13   
gi|21263659|sp|Q8WTQ7|GRK7_HUMAN  G protein-coupled receptor k...  72.8    9e-13   
gi|29427817|sp|Q8IVH8|M4K3_HUMAN  Mitogen-activated protein ki...  72.8    9e-13   
gi|68565604|sp|Q96GX5|MASTL_HUMAN  Microtubule-associated serine/  72.4    1e-12   
gi|1706663|sp|P54762|EPHB1_HUMAN  Ephrin type-B receptor 1 pre...  72.4    1e-12   
gi|114152|sp|P25098|ARBK1_HUMAN  Beta-adrenergic receptor kina...  72.4    1e-12   
gi|22653927|sp|O94921|PFTK1_HUMAN  Serine/threonine-protein kinas  72.4    1e-12   
gi|28201830|sp|Q96RU7|TRIB3_HUMAN  Tribbles homolog 3 (TRB-3) ...  72.0    2e-12   
gi|29840818|sp|Q9UKE5|TNIK_HUMAN  TRAF2 and NCK-interacting kinas  72.0    2e-12   
gi|400127|sp|P07332|FES_HUMAN  Proto-oncogene tyrosine-protein ki  71.6    2e-12   
gi|68565548|sp|Q9NYL2|MLTK_HUMAN  Mitogen-activated protein ki...  71.6    2e-12   
gi|1177044|sp|P43403|ZAP70_HUMAN  Tyrosine-protein kinase ZAP-...  71.2    3e-12   
gi|20455241|sp|Q9Y572|RIPK3_HUMAN  Receptor-interacting serine...  71.2    3e-12   
gi|76803654|sp|P29323|EPHB2_HUMAN  Ephrin type-B receptor 2 pr...  71.2    3e-12 
gi|1711371|sp|P54764|EPHA4_HUMAN  Ephrin type-A receptor 4 pre...  71.2    3e-12   
gi|125333|sp|P29317|EPHA2_HUMAN  Ephrin type-A receptor 2 prec...  71.2    3e-12   
gi|74762569|sp|Q8NFD2|ANKK1_HUMAN  Ankyrin repeat and protein ...  71.2    3e-12   
gi|2499596|sp|Q16659|MK06_HUMAN  Mitogen-activated protein kin...  70.9    4e-12   
gi|68846922|sp|Q15375|EPHA7_HUMAN  Ephrin type-A receptor 7 pr...  70.9    4e-12 
gi|464971|sp|P33981|TTK_HUMAN  Dual specificity protein kinase...  70.5    5e-12   
gi|1705722|sp|P50613|CDK7_HUMAN  Cell division protein kinase ...  70.5    5e-12   
gi|12643557|sp|O43318|M3K7_HUMAN  Mitogen-activated protein ki...  70.5    5e-12   
gi|46577075|sp|Q8NEV4|MYO3A_HUMAN  Myosin IIIA                     70.5    5e-12   
gi|47117832|sp|P21709|EPHA1_HUMAN  Ephrin type-A receptor 1 pr...  70.5    5e-12   
gi|6685617|sp|Q99683|M3K5_HUMAN  Mitogen-activated protein kin...  70.1    6e-12   
gi|6166188|sp|P32298|GRK4_HUMAN  G protein-coupled receptor ki...  69.7    8e-12   
gi|2499660|sp|Q15569|TESK1_HUMAN  Dual specificity testis-spec...  69.3    1e-11   
gi|14548079|sp|Q14164|IKKE_HUMAN  Inhibitor of nuclear factor ...  69.3    1e-11   
gi|45593475|sp|Q12851|M4K2_HUMAN  Mitogen-activated protein ki...  68.9    1e-11   
gi|30316147|sp|Q9Y4K4|M4K5_HUMAN  Mitogen-activated protein ki...  68.6    2e-11   
gi|119554|sp|P28482|MK01_HUMAN  Mitogen-activated protein kina...  68.6    2e-11   
gi|17375734|sp|O14976|GAK_HUMAN  Cyclin G-associated kinase        68.6    2e-11   
gi|29427585|sp|O95819|M4K4_HUMAN  Mitogen-activated protein ki...  68.6    2e-11   
gi|56405328|sp|P29597|TYK2_HUMAN  Non-receptor tyrosine-protein k  68.2    2e-11   
gi|48428273|sp|Q9UPZ9|ICK_HUMAN  Serine/threonine-protein kina...  68.2    2e-11   
gi|12644292|sp|P49840|GSK3A_HUMAN  Glycogen synthase kinase-3 alp  68.2    2e-11   
gi|13432166|sp|P20794|MAK_HUMAN  Serine/threonine-protein kina...  67.8    3e-11   
gi|76803655|sp|P54753|EPHB3_HUMAN  Ephrin type-B receptor 3 pr...  67.8    3e-11 
gi|2499603|sp|Q15759|MK11_HUMAN  Mitogen-activated protein kin...  67.8    3e-11   
gi|1345718|sp|P49336|CDK8_HUMAN  Cell division protein kinase 8 (  67.8    3e-11   
gi|20455502|sp|P49841|GSK3B_HUMAN  Glycogen synthase kinase-3 bet  67.8    3e-11   
gi|55977123|sp|P68400|CSK21_HUMAN  Casein kinase II, alpha chain   67.8    3e-11   
gi|23831382|sp|Q13523|PRP4B_HUMAN  Serine/threonine-protein ki...  67.4    4e-11   
gi|6685614|sp|O95382|M3K6_HUMAN  Mitogen-activated protein kinase  67.4    4e-11 
gi|12643404|sp|O60674|JAK2_HUMAN  Tyrosine-protein kinase JAK2 (J  67.4    4e-11   
gi|1169123|sp|P42679|MATK_HUMAN  Megakaryocyte-associated tyro...  67.4    4e-11   
gi|1174527|sp|P43405|KSYK_HUMAN  Tyrosine-protein kinase SYK (Spl  67.0    5e-11   
gi|119534|sp|P21860|ERBB3_HUMAN  Receptor tyrosine-protein kin...  67.0    5e-11   
gi|68571767|sp|P80192|M3K9_HUMAN  Mitogen-activated protein ki...  66.6    7e-11 
gi|74762512|sp|Q8N165|PDK1L_HUMAN  Serine/threonine-protein ki...  66.6    7e-11   
gi|19860819|sp|P54760|EPHB4_HUMAN  Ephrin type-B receptor 4 pr...  66.6    7e-11   
gi|50403745|sp|P52333|JAK3_HUMAN  Tyrosine-protein kinase JAK3...  66.6    7e-11   
gi|266423|sp|Q00534|CDK6_HUMAN  Cell division protein kinase 6...  66.6    7e-11   
gi|25009462|sp|Q96S53|TESK2_HUMAN  Dual specificity testis-spe...  66.6    7e-11   
gi|52783106|sp|O95835|LATS1_HUMAN  Serine/threonine-protein ki...  66.6    7e-11   
gi|60393639|sp|Q13546|RIPK1_HUMAN  Receptor-interacting serine...  66.2    9e-11 
gi|55976573|sp|Q99640|PMYT1_HUMAN  Membrane-associated tyrosin...  66.2    9e-11   
gi|13432140|sp|P22455|FGFR4_HUMAN  Fibroblast growth factor re...  66.2    9e-11   
gi|6831583|sp|O14733|MP2K7_HUMAN  Dual specificity mitogen-act...  66.2    9e-11   
gi|120050|sp|P22607|FGFR3_HUMAN  Fibroblast growth factor rece...  66.2    9e-11   
gi|74761953|sp|Q9UHD2|TBK1_HUMAN  Serine/threonine-protein kin...  66.2    9e-11   
gi|6685642|sp|O15264|MK13_HUMAN  Mitogen-activated protein kin...  65.9    1e-10   
gi|52783149|sp|Q9NRM7|LATS2_HUMAN  Serine/threonine-protein ki...  65.9    1e-10   
gi|27923858|sp|Q8TDR2|STK35_HUMAN  Serine/threonine-protein ki...  65.5    1e-10   
gi|1170596|sp|P45985|MP2K4_HUMAN  Dual specificity mitogen-act...  65.5    1e-10   
gi|50401181|sp|Q9NWZ3|IRAK4_HUMAN  Interleukin-1 receptor-asso...  65.1    2e-10   
gi|3913590|sp|Q15303|ERBB4_HUMAN  Receptor tyrosine-protein ki...  65.1    2e-10   
gi|71153820|sp|Q5TCX8|M3KL4_HUMAN  Mitogen-activated protein k...  65.1    2e-10   
gi|24211444|sp|Q96Q40|AL2S7_HUMAN  Serine/threonine-protein ki...  65.1    2e-10   
gi|60391917|sp|Q9BWU1|CD2L6_HUMAN  Cell division cycle 2-like ...  64.7    3e-10   
gi|2499599|sp|Q13164|MK07_HUMAN  Mitogen-activated protein kin...  64.7    3e-10   
gi|46577085|sp|Q8WXR4|MYO3B_HUMAN  Myosin IIIB                     64.7    3e-10   
gi|1168867|sp|P11802|CDK4_HUMAN  Cell division protein kinase ...  64.3    3e-10   
gi|549081|sp|P35590|TIE1_HUMAN  Tyrosine-protein kinase receptor   63.9    4e-10   
gi|2497562|sp|Q16288|NTRK3_HUMAN  NT-3 growth factor receptor ...  63.9    4e-10   
gi|1717829|sp|Q06418|TYRO3_HUMAN  Tyrosine-protein kinase rece...  63.9    4e-10   
gi|74708170|sp|Q5S007|LRRK2_HUMAN  Leucine-rich repeat protein ki  63.9    4e-10   
gi|547807|sp|P07949|RET_HUMAN  Proto-oncogene tyrosine-protein...  63.5    6e-10   
gi|2497560|sp|Q16620|NTRK2_HUMAN  BDNF/NT-3 growth factors rec...  63.2    7e-10   
gi|74762207|sp|Q5JZY3|EPHAA_HUMAN  Ephrin type-A receptor 10 prec  63.2    7e-10   
gi|37999491|sp|Q07912|ACK1_HUMAN  Activated CDC42 kinase 1 (AC...  62.8    1e-09   
gi|1709088|sp|P52564|MP2K6_HUMAN  Dual specificity mitogen-act...  62.4    1e-09   
gi|60391728|sp|Q6Q788|APOA5_HUMAN  Apolipoprotein A-V precurso...  62.4    1e-09   
gi|119533|sp|P04626|ERBB2_HUMAN  Receptor tyrosine-protein kin...  62.0    2e-09   
gi|729008|sp|Q08345|DDR1_HUMAN  Epithelial discoidin domain-co...  62.0    2e-09   
gi|125266|sp|P19784|CSK22_HUMAN  Casein kinase II, alpha' chain (  61.2    3e-09   
gi|14285588|sp|Q99558|M3K14_HUMAN  Mitogen-activated protein k...  61.2    3e-09   
gi|32172458|sp|Q9BQI3|E2AK1_HUMAN  Eukaryotic translation init...  60.8    4e-09   
gi|6226784|sp|Q15131|CDK10_HUMAN  Cell division protein kinase...  60.8    4e-09   
gi|2497564|sp|Q16832|DDR2_HUMAN  Discoidin domain-containing r...  60.8    4e-09   
gi|2811086|sp|P00533|EGFR_HUMAN  Epidermal growth factor recep...  60.1    6e-09   
gi|29427916|sp|Q92918|M4K1_HUMAN  Mitogen-activated protein ki...  60.1    6e-09   
gi|50403742|sp|P41279|M3K8_HUMAN  Mitogen-activated protein ki...  59.7    8e-09   
gi|59896668|sp|Q13470|TNK1_HUMAN  Non-receptor tyrosine-protei...  59.7    8e-09   
gi|125060|sp|P23458|JAK1_HUMAN  Tyrosine-protein kinase JAK1 (Jan  59.3    1e-08   
gi|82582303|sp|Q59H18|TNI3K_HUMAN  Serine/threonine-protein ki...  58.5    2e-08 
gi|464868|sp|Q02763|TIE2_HUMAN  Angiopoietin-1 receptor precur...  58.2    2e-08   
gi|3183003|sp|Q14289|FAK2_HUMAN  Protein tyrosine kinase 2 bet...  58.2    2e-08   
gi|34222653|sp|Q9NSY1|BMP2K_HUMAN  BMP-2-inducible protein kinase  58.2    2e-08   
gi|12644000|sp|P14616|INSRR_HUMAN  Insulin receptor-related pr...  57.8    3e-08   
gi|13878706|sp|Q01974|ROR2_HUMAN  Tyrosine-protein kinase tran...  57.8    3e-08   
gi|41017258|sp|Q9UQ07|MOK_HUMAN  MAPK/MAK/MRK overlapping kina...  57.8    3e-08   
gi|33112647|sp|P06213|INSR_HUMAN  Insulin receptor precursor (...  57.8    3e-08   
gi|10719883|sp|P57078|RIPK4_HUMAN  Serine/threonine-protein ki...  57.0    5e-08   
gi|20455217|sp|O43353|RIPK2_HUMAN  Receptor-interacting serine...  57.0    5e-08   
gi|19924290|sp|Q01973|ROR1_HUMAN  Tyrosine-protein kinase tran...  57.0    5e-08   
gi|125527|sp|P19525|E2AK2_HUMAN  Interferon-induced, double-st...  57.0    5e-08   
gi|61213019|sp|Q9P2K8|E2AK4_HUMAN  Eukaryotic translation init...  57.0    5e-08   
gi|34922255|sp|Q9UQ88|CD2L2_HUMAN  PITSLRE serine/threonine-pr...  57.0    5e-08   
gi|34978359|sp|P21127|CD2L1_HUMAN  PITSLRE serine/threonine-pr...  56.6    7e-08   
gi|2851601|sp|P04629|NTRK1_HUMAN  High affinity nerve growth f...  56.2    9e-08   
gi|6686295|sp|Q02779|M3K10_HUMAN  Mitogen-activated protein ki...  55.1    2e-07   
gi|68566308|sp|Q9NR20|DYRK4_HUMAN  Dual specificity tyrosine-phos  54.7    3e-07 
gi|125497|sp|P00540|MOS_HUMAN  Proto-oncogene serine/threonine...  54.7    3e-07   
gi|48429194|sp|P30530|UFO_HUMAN  Tyrosine-protein kinase receptor  54.7    3e-07   
gi|51315812|sp|O75460|ERN1_HUMAN  Serine/threonine-protein kin...  54.3    3e-07   
gi|18203329|sp|Q9NZJ5|E2AK3_HUMAN  Eukaryotic translation init...  54.3    3e-07   
gi|125484|sp|P08581|MET_HUMAN  Hepatocyte growth factor recept...  54.3    3e-07   
gi|56749062|sp|Q6VAB6|KSR2_HUMAN  Kinase suppressor of ras-2 (hKS  54.3    3e-07   
gi|13626369|sp|O43781|DYRK3_HUMAN  Dual specificity tyrosine-phos  54.3    3e-07   
gi|24638466|sp|P46734|MP2K3_HUMAN  Dual specificity mitogen-ac...  53.5    6e-07   
gi|46577677|sp|O75716|STK16_HUMAN  Serine/threonine-protein ki...  53.1    8e-07   
gi|1705918|sp|P49759|CLK1_HUMAN  Dual specificity protein kinase   52.8    1e-06   
gi|13626380|sp|Q92630|DYRK2_HUMAN  Dual specificity tyrosine-phos  52.4    1e-06   
gi|9296963|sp|Q9Y463|DYR1B_HUMAN  Dual specificity tyrosine-ph...  52.4    1e-06   
gi|124240|sp|P08069|IGF1R_HUMAN  Insulin-like growth factor 1 ...  52.4    1e-06   
gi|20532386|sp|Q13705|AVR2B_HUMAN  Activin receptor type 2B pr...  52.4    1e-06   
gi|125361|sp|P17948|VGFR1_HUMAN  Vascular endothelial growth f...  51.6    2e-06   
gi|6919882|sp|O15197|EPHB6_HUMAN  Ephrin type-B receptor 6 pre...  51.6    2e-06   
gi|8134650|sp|Q13308|PTK7_HUMAN  Tyrosine-protein kinase-like ...  51.6    2e-06   
gi|62901083|sp|Q6J9G0|STYK1_HUMAN  Tyrosine protein-kinase STY...  51.6    2e-06   
gi|61252444|sp|P36894|BMR1A_HUMAN  Bone morphogenetic protein ...  51.2    3e-06 
gi|3219996|sp|Q13627|DYR1A_HUMAN  Dual specificity tyrosine-ph...  51.2    3e-06   
gi|56749095|sp|Q8IVT5|KSR1_HUMAN  Kinase suppressor of ras-1 (Kin  51.2    3e-06   
gi|585912|sp|Q04912|RON_HUMAN  Macrophage-stimulating protein ...  50.8    4e-06   
gi|2506798|sp|P08922|ROS_HUMAN  Proto-oncogene tyrosine-protein k  50.8    4e-06   
gi|50400806|sp|O15146|MUSK_HUMAN  Muscle, skeletal receptor ty...  50.8    4e-06   
gi|10720097|sp|Q12866|MERTK_HUMAN  Proto-oncogene tyrosine-pro...  50.4    5e-06   
gi|114722|sp|P27037|AVR2A_HUMAN  Activin receptor type 2A prec...  50.1    6e-06   
gi|74762722|sp|Q9C0K7|AL2S2_HUMAN  Serine/threonine-protein ki...  50.1    6e-06   
gi|1351419|sp|P30291|WEE1_HUMAN  Wee1-like protein kinase (WEE1hu  49.7    8e-06   
gi|1718189|sp|P35916|VGFR3_HUMAN  Vascular endothelial growth ...  49.7    8e-06   
gi|34922132|sp|Q9HAZ1|CLK4_HUMAN  Dual specificity protein kinase  49.7    8e-06   
gi|9087218|sp|P35968|VGFR2_HUMAN  Vascular endothelial growth ...  48.5    2e-05   
gi|51315898|sp|Q76MJ5|ERN2_HUMAN  Serine/threonine-protein kin...  48.5    2e-05   
gi|1706243|sp|P51841|GUC2F_HUMAN  Retinal guanylyl cyclase 2 p...  48.1    2e-05   
gi|20137251|sp|Q9UM73|ALK_HUMAN  ALK tyrosine kinase receptor ...  47.0    5e-05   
gi|21431782|sp|Q9H2X6|HIPK2_HUMAN  Homeodomain-interacting protei  46.6    7e-05   
gi|34395641|sp|Q86Z02|HIPK1_HUMAN  Homeodomain-interacting protei  45.8    1e-04   
gi|113916|sp|P20594|ANPRB_HUMAN  Atrial natriuretic peptide re...  45.8    1e-04   
gi|114039|sp|P02649|APOE_HUMAN  Apolipoprotein E precursor (Apo-E  45.4    2e-04   
gi|462447|sp|Q04771|ACVR1_HUMAN  Activin receptor type I precu...  45.4    2e-04   
gi|544320|sp|P36888|FLT3_HUMAN  FL cytokine receptor precursor...  45.4    2e-04   
gi|61213741|sp|Q9H422|HIPK3_HUMAN  Homeodomain-interacting pro...  45.1    2e-04   
gi|12230224|sp|O43187|IRAK2_HUMAN  Interleukin-1 receptor-associa  45.1    2e-04   
gi|586086|sp|P37173|TGFR2_HUMAN  TGF-beta receptor type II pre...  44.7    3e-04   
gi|3915750|sp|P37023|ACVL1_HUMAN  Serine/threonine-protein kin...  44.7    3e-04   
gi|1170674|sp|P29376|LTK_HUMAN  Leukocyte tyrosine kinase rece...  44.3    4e-04   
gi|129892|sp|P16234|PGFRA_HUMAN  Alpha platelet-derived growth...  43.5    6e-04   
gi|1346369|sp|P49674|KC1E_HUMAN  Casein kinase I isoform epsilon   43.5    6e-04   
gi|27923980|sp|P48730|KC1D_HUMAN  Casein kinase I isoform delta (  43.5    6e-04   
gi|47117932|sp|Q9Y6M4|KC1G3_HUMAN  Casein kinase I isoform gamma-  43.1    8e-04   
gi|6226778|sp|O00238|BMR1B_HUMAN  Bone morphogenetic protein r...  43.1    8e-04   
gi|18202957|sp|Q9HCP0|KC1G1_HUMAN  Casein kinase I isoform gamma-  43.1    8e-04   
gi|125472|sp|P10721|KIT_HUMAN  Mast/stem cell growth factor re...  42.7    0.001   
gi|1345920|sp|Q02846|GUC2D_HUMAN  Retinal guanylyl cyclase 1 p...  42.7    0.001   
gi|24211880|sp|Q8TAS1|UHMK1_HUMAN  Serine/threonine-protein ki...  42.4    0.001   
gi|129890|sp|P09619|PGFRB_HUMAN  Beta platelet-derived growth ...  42.4    0.001   
gi|1705919|sp|P49760|CLK2_HUMAN  Dual specificity protein kinase   42.0    0.002   
gi|113912|sp|P16066|ANPRA_HUMAN  Atrial natriuretic peptide re...  41.2    0.003   
gi|547775|sp|P36896|ACV1B_HUMAN  Activin receptor type 1B prec...  41.2    0.003   
gi|55584013|sp|Q9Y616|IRAK3_HUMAN  Interleukin-1 receptor-asso...  40.8    0.004   
gi|3024060|sp|P78368|KC1G2_HUMAN  Casein kinase I isoform gamma-2  40.4    0.005   
gi|67476728|sp|P42566|EP15_HUMAN  Epidermal growth factor rece...  40.4    0.005 
gi|547777|sp|P36897|TGFR1_HUMAN  TGF-beta receptor type I prec...  40.0    0.007   
gi|20141240|sp|P49761|CLK3_HUMAN  Dual specificity protein kinase  39.7    0.009   
gi|34222508|sp|Q15075|EEA1_HUMAN  Early endosome antigen 1 (En...  39.7    0.009   
gi|547770|sp|P07333|CSF1R_HUMAN  Macrophage colony-stimulating...  39.3    0.011   
gi|12643724|sp|Q13873|BMPR2_HUMAN  Bone morphogenetic protein ...  38.9    0.015   
gi|123682|sp|P25092|GUC2C_HUMAN  Heat-stable enterotoxin recep...  38.9    0.015   
gi|23822112|sp|Q9P2E9|RRBP1_HUMAN  Ribosome-binding protein 1 ...  38.5    0.019   
gi|21264536|sp|P45379|TNNT2_HUMAN  Troponin T, cardiac muscle ...  38.5    0.019   
gi|83305809|sp|Q96KB5|TOPK_HUMAN  T-lymphokine-activated kille...  38.5    0.019 
gi|9973397|sp|Q13418|ILK1_HUMAN  Integrin-linked protein kinas...  38.1    0.025   
gi|31077177|sp|P48729|KC1A_HUMAN  Casein kinase I isoform alpha (  38.1    0.025   
gi|9973390|sp|P57043|ILK2_HUMAN  Integrin-linked protein kinase 2  37.7    0.033   
gi|20178343|sp|Q14141|SEPT6_HUMAN  Septin-6                        37.4    0.043   
gi|82581558|sp|Q8TDY2|RBCC1_HUMAN  RB1-inducible coiled-coil prot  36.6    0.074 
gi|417216|sp|P33176|KINH_HUMAN  Kinesin heavy chain (Ubiquitous k  36.6    0.074   
gi|74753268|sp|Q9UDT6|CYLN2_HUMAN  Cytoplasmic linker protein ...  36.2    0.096   
gi|8928535|sp|P51617|IRAK1_HUMAN  Interleukin-1 receptor-associat  36.2    0.096   
gi|1710811|sp|P34925|RYK_HUMAN  Tyrosine-protein kinase RYK precu  36.2    0.096   
gi|14194461|sp|Q99996|AKAP9_HUMAN  A-kinase anchor protein 9 (...  36.2    0.096   
gi|17375490|sp|Q14203|DYNA_HUMAN  Dynactin-1 (150 kDa dynein-a...  35.8    0.13    
gi|33518637|sp|P45378|TNNT3_HUMAN  Troponin T, fast skeletal m...  35.8    0.13    
gi|1709851|sp|P23246|SFPQ_HUMAN  Splicing factor, proline- and...  35.4    0.16    
gi|1174800|sp|P13805|TNNT1_HUMAN  Troponin T, slow skeletal mu...  35.4    0.16    
gi|1346640|sp|P35580|MYH10_HUMAN  Myosin-10 (Myosin heavy chai...  35.4    0.16    
gi|33301318|sp|Q92614|MY18A_HUMAN  Myosin-18A (Myosin XVIIIa) ...  35.0    0.21    
gi|20455324|sp|Q9H2D6|TARA_HUMAN  TRIO and F-actin binding pro...  35.0    0.21    
gi|1346343|sp|P04264|K2C1_HUMAN  Keratin, type II cytoskeletal...  35.0    0.21    
gi|586120|sp|Q07283|TRHY_HUMAN  Trichohyalin                       35.0    0.21    
gi|45593722|sp|Q86Y07|VRK2_HUMAN  Serine/threonine-protein kin...  35.0    0.21    
gi|71151982|sp|Q7Z406|MYH14_HUMAN  Myosin-14 (Myosin heavy cha...  35.0    0.21    
gi|47115840|sp|Q8N752|KC1AL_HUMAN  Casein kinase I isoform alpha-  35.0    0.21    
gi|50403702|sp|O95613|PCNT_HUMAN  Pericentrin (Pericentrin B) (Ke  35.0    0.21    
gi|48428484|sp|Q9BXM7|PINK1_HUMAN  Serine/threonine-protein ki...  34.7    0.28    
gi|68068057|sp|Q8NHQ8|RASF8_HUMAN  Ras association domain-cont...  34.7    0.28  
gi|88909227|sp|Q6WCQ1|MRIP_HUMAN  Myosin phosphatase Rho-inter...  34.7    0.28  
gi|62511032|sp|Q6UVJ0|SAS6_HUMAN  Spindle assembly abnormal prote  34.3    0.37    
gi|21759000|sp|Q12955|ANK3_HUMAN  Ankyrin-3 (ANK-3) (Ankyrin G)    34.3    0.37    
gi|2493434|sp|Q01082|SPTB2_HUMAN  Spectrin beta chain, brain 1...  34.3    0.37    
gi|76803557|sp|P11532|DMD_HUMAN  Dystrophin                        34.3    0.37  
gi|41688595|sp|Q9UJC3|HOOK1_HUMAN  Hook homolog 1 (h-hook1) (hHK1  33.9    0.48    
gi|25009466|sp|Q9UIF3|TEKT2_HUMAN  Tektin-2 (Testicular tektin...  33.9    0.48    
gi|32469766|sp|Q92805|GOGA1_HUMAN  Golgin subfamily A member 1 (G  33.9    0.48  
gi|23831094|sp|O00291|HIP1_HUMAN  Huntingtin-interacting protein   33.9    0.48    
gi|17372543|sp|Q12934|BFSP1_HUMAN  Filensin (Beaded filament s...  33.5    0.62    
gi|62899891|sp|Q9HC77|CENPJ_HUMAN  Centromere protein J (Centr...  33.5    0.62    
gi|417031|sp|P32455|GBP1_HUMAN  Interferon-induced guanylate-b...  33.5    0.62    
gi|1730008|sp|P53804|TTC3_HUMAN  Tetratricopeptide repeat prot...  33.5    0.62    
gi|29839561|sp|Q8NF91|SYNE1_HUMAN  Nesprin-1 (Nuclear envelope...  33.5    0.62    
gi|30912698|sp|Q8NB25|CF060_HUMAN  Hypothetical protein C6orf60    33.5    0.62    
gi|14195007|sp|Q15149|PLEC1_HUMAN  Plectin 1 (PLTN) (PCN) (Hemide  33.1    0.82    
gi|47606000|sp|Q15276|RABE1_HUMAN  Rab GTPase binding effector...  33.1    0.82  
gi|84029264|sp|Q3T8J9|GON4_HUMAN  Protein GON4 (GON-4 homolog) (G  33.1    0.82  
gi|62288025|sp|Q66GS9|CEP4_HUMAN  Centrosomal protein 4 (Centr...  33.1    0.82    
gi|12643718|sp|Q13439|GOGA4_HUMAN  Golgin subfamily A member 4...  33.1    0.82    
gi|56405385|sp|Q9HCM9|TRI39_HUMAN  Tripartite motif protein 39...  32.7    1.1     
gi|50401687|sp|Q9NVA2|SEP11_HUMAN  Septin-11                       32.7    1.1     
gi|547754|sp|P35908|K22E_HUMAN  Keratin, type II cytoskeletal ...  32.7    1.1     
gi|84027766|sp|Q5VTR2|BRE1A_HUMAN  Ubiquitin ligase protein BR...  32.7    1.1   
gi|28201804|sp|Q14789|GOGB1_HUMAN  Golgin subfamily B member 1...  32.7    1.1     
gi|12643528|sp|O00311|CDC7_HUMAN  Cell division cycle 7-relate...  32.7    1.1     
gi|266902|sp|P30622|REST_HUMAN  Restin (Cytoplasmic linker pro...  32.3    1.4     
gi|20138952|sp|Q15025|NAF1_HUMAN  Nef-associated factor 1 (Naf...  32.3    1.4     
gi|3041707|sp|P13535|MYH8_HUMAN  Myosin-8 (Myosin heavy chain,...  32.3    1.4     
gi|68068009|sp|P49756|RBM25_HUMAN  Probable RNA-binding protei...  32.3    1.4   
gi|71153344|sp|Q96KP6|TNIP3_HUMAN  TNFAIP3-interacting protein...  32.3    1.4     
gi|20532393|sp|O15230|LAMA5_HUMAN  Laminin alpha-5 chain precurso  32.3    1.4     
gi|48474671|sp|Q9NSB2|KRHB4_HUMAN  Keratin, type II cuticular Hb4  32.0    1.8     
gi|67472134|sp|Q86YS3|RFIP4_HUMAN  Rab11 family-interacting prote  32.0    1.8     
gi|56405387|sp|Q9UPN3|MACF1_HUMAN  Microtubule-actin crosslink...  32.0    1.8     
gi|29337005|sp|Q9UQE7|SMC3_HUMAN  Structural maintenance of ch...  32.0    1.8     
gi|23503070|sp|Q06547|GABP2_HUMAN  GA binding protein beta cha...  32.0    1.8     
gi|30316105|sp|Q96PK2|MACF4_HUMAN  Microtubule-actin crosslinking  32.0    1.8     
gi|6136547|sp|O60299|Y0552_HUMAN  Hypothetical protein KIAA0552    31.6    2.4     
gi|23396633|sp|Q15058|KIF14_HUMAN  Kinesin-like protein KIF14      31.6    2.4     
gi|32470610|sp|Q08378|GOGA3_HUMAN  Golgin subfamily A member 3...  31.6    2.4     
gi|1350802|sp|Q05823|RN5A_HUMAN  2-5A-dependent ribonuclease (...  31.6    2.4     
gi|61223942|sp|Q9UBC2|EP15R_HUMAN  Epidermal growth factor rec...  31.6    2.4     
gi|60392986|sp|Q92878|RAD50_HUMAN  DNA repair protein RAD50 (hRAD  31.2    3.1     
gi|8134814|sp|Q9UPW0|FOXJ3_HUMAN  Forkhead box protein J3          31.2    3.1     
gi|3913957|sp|O14782|KIF3C_HUMAN  Kinesin-like protein KIF3C       31.2    3.1     
gi|62286590|sp|O94986|CE152_HUMAN  Centrosomal protein of 152 kDa  31.2    3.1     
gi|2498313|sp|Q16643|DREB_HUMAN  Drebrin (Developmentally regulat  31.2    3.1     
gi|17367904|sp|O15020|SPTN2_HUMAN  Spectrin beta chain, brain ...  31.2    3.1     
gi|68565596|sp|Q8IZL2|MAML2_HUMAN  Mastermind-like protein 2 (Mam  31.2    3.1     
gi|68840132|sp|Q96SN8|CK5P2_HUMAN  CDK5 regulatory subunit-ass...  31.2    3.1   
gi|54035738|sp|Q9Y2D8|ADIP_HUMAN  Afadin- and alpha-actinin-bi...  30.8    4.0     
gi|42558969|sp|Q13136|LIPA1_HUMAN  Liprin-alpha-1 (Protein tyr...  30.8    4.0     
gi|25008939|sp|O75626|PRDM1_HUMAN  PR-domain zinc finger prote...  30.8    4.0     
gi|62512161|sp|O95239|KIF4A_HUMAN  Chromosome-associated kinesin   30.8    4.0     
gi|32469788|sp|Q9NYA3|GOGA6_HUMAN  Golgin subfamily A member 6...  30.8    4.0     
gi|17373489|sp|Q13111|CAF1A_HUMAN  Chromatin assembly factor 1...  30.8    4.0     
gi|400793|sp|Q00722|PLCB2_HUMAN  1-phosphatidylinositol-4,5-bi...  30.8    4.0     
gi|55976299|sp|Q14134|TRI29_HUMAN  Tripartite motif protein 29...  30.8    4.0     
gi|14194715|sp|Q92817|EVPL_HUMAN  Envoplakin (210 kDa paraneop...  30.8    4.0     
gi|22653665|sp|Q9NRL2|BAZ1A_HUMAN  Bromodomain adjacent to zin...  30.8    4.0     
gi|29839588|sp|Q8WXH0|SYNE2_HUMAN  Nesprin-2 (Nuclear envelope...  30.8    4.0     
gi|28201884|sp|P78424|PO6F2_HUMAN  POU domain, class 6, transc...  30.8    4.0     
gi|73620945|sp|O94833|BPAEA_HUMAN  Bullous pemphigoid antigen ...  30.8    4.0   
gi|12643326|sp|Q9ULV3|CIZ1_HUMAN  Cip1-interacting zinc finger pr  30.8    4.0     
gi|12643319|sp|O75665|OFD1_HUMAN  Oral-facial-digital syndrome 1   30.4    5.3     
gi|74745646|sp|Q5T9A4|ATD3B_HUMAN  ATPase family AAA domain-conta  30.4    5.3     
gi|6166599|sp|P35579|MYH9_HUMAN  Myosin-9 (Myosin heavy chain,...  30.4    5.3     
gi|83288393|sp|Q92954|PRG4_HUMAN  Proteoglycan-4 precursor (Lu...  30.4    5.3     
gi|20454925|sp|Q96RT7|GCP6_HUMAN  Gamma-tubulin complex component  30.4    5.3     
gi|1345731|sp|P49454|CENPF_HUMAN  CENP-F kinetochore protein (...  30.4    5.3     
gi|1709078|sp|P50221|MEOX1_HUMAN  Homeobox protein MOX-1 (Mesench  30.4    5.3     
gi|45593726|sp|Q99986|VRK1_HUMAN  Serine/threonine-protein kin...  30.4    5.3     
gi|51701377|sp|O15083|ERC2_HUMAN  ERC protein 2                    30.4    5.3     
gi|13432177|sp|P35749|MYH11_HUMAN  Myosin-11 (Myosin heavy chain,  30.4    5.3     
gi|33112673|sp|Q9Y496|KIF3A_HUMAN  Kinesin-like protein KIF3A ...  30.4    5.3     
gi|77416379|sp|Q9UPN4|AZI1_HUMAN  5-azacytidine-induced protei...  30.4    5.3     
gi|57015374|sp|P49750|YLPM1_HUMAN  YLP motif containing protein 1  30.4    5.3     
gi|68053233|sp|Q9H7L9|SDS3_HUMAN  Sin3 histone deacetylase corepr  30.0    6.9     
gi|13124568|sp|Q9UPE1|STK23_HUMAN  Serine/threonine-protein ki...  30.0    6.9     
gi|18202959|sp|Q9HCU9|BRMS1_HUMAN  Breast cancer metastasis-suppr  30.0    6.9     
gi|134798|sp|P11277|SPTB1_HUMAN  Spectrin beta chain, erythrocyte  30.0    6.9     
gi|25452905|sp|Q9H501|CT006_HUMAN  Hypothetical protein C20orf6    30.0    6.9     
gi|74749877|sp|Q7L014|DDX46_HUMAN  Probable ATP-dependent RNA ...  30.0    6.9     
gi|14916998|sp|P00390|GSHR_HUMAN  Glutathione reductase, mitochon  30.0    6.9     
gi|1169868|sp|P32456|GBP2_HUMAN  Interferon-induced guanylate-...  30.0    6.9     
gi|731165|sp|Q02040|XE7_HUMAN  B-lymphocyte antigen precursor ...  30.0    6.9     
gi|2498204|sp|Q05682|CALD1_HUMAN  Caldesmon (CDM)                  30.0    6.9     
gi|88909601|sp|Q5BJE1|CR034_HUMAN  Protein C18orf34                30.0    6.9   
gi|51338794|sp|P78559|MAP1A_HUMAN  Microtubule-associated prot...  30.0    6.9     
gi|14195666|sp|O60841|IF2P_HUMAN  Eukaryotic translation initi...  30.0    6.9     
gi|45645200|sp|Q92599|SEPT8_HUMAN  Septin-8                        29.6    9.0     
gi|38372394|sp|Q9NUV9|GIMA4_HUMAN  GTPase, IMAP family member ...  29.6    9.0     
gi|2833266|sp|Q15696|U2AFM_HUMAN  U2 small nuclear ribonucleop...  29.6    9.0     
gi|20139283|sp|Q9UL16|CCD19_HUMAN  Coiled-coil domain-containi...  29.6    9.0     
gi|8134347|sp|O43683|BUB1_HUMAN  Mitotic checkpoint serine/thr...  29.6    9.0     
gi|55583953|sp|Q8N3L3|TXLNB_HUMAN  Beta-taxilin (Muscle-derived p  29.6    9.0     
gi|51827892|sp|Q8IUD2|RB6I2_HUMAN  RAB6-interacting protein 2 (ER  29.6    9.0     
gi|33302627|sp|Q15643|TRIPB_HUMAN  Thyroid receptor-interactin...  29.6    9.0     
gi|1730009|sp|P12270|TPR_HUMAN  Nucleoprotein TPR                  29.6    9.0     
gi|3023440|sp|Q92793|CBP_HUMAN  CREB-binding protein               29.6    9.0     
gi|52000729|sp|Q8WWM7|ATX2L_HUMAN  Ataxin-2-like protein (Atax...  29.6    9.0     
gi|23503097|sp|P57071|PRD15_HUMAN  PR-domain zinc finger protein   29.6    9.0     
gi|6226826|sp|O75330|HMMR_HUMAN  Hyaluronan mediated motility ...  29.6    9.0     
gi|41017595|sp|O95153|RIMB1_HUMAN  Peripheral-type benzodiazep...  29.6    9.0     
gi|20178341|sp|P47974|TISD_HUMAN  Butyrate response factor 2 (...  29.6    9.0     

Alignments

>gi|113992|sp|P02647|APOA1_HUMAN  Apolipoprotein A-I precursor (Apo-AI) (ApoA-I) [Contains: Apolipoprotein 
A-I(1-242)]
Length=267

 Score =  473 bits (1217),  Expect = 2e-133
 Identities = 253/253 (100%), Positives = 253/253 (100%), Gaps = 0/253 (0%)

Query  1139  GSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNW  1198
             GSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNW
Sbjct  15    GSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNW  74

Query  1199  DSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQE  1258
             DSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQE
Sbjct  75    DSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQE  134

Query  1259  EMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDel  1318
             EMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDEL
Sbjct  135   EMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDEL  194

Query  1319  rqrlaarlealkeNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFL  1378
             RQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFL
Sbjct  195   RQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFL  254

Query  1379  SALEEYTKKLNTQ  1391
             SALEEYTKKLNTQ
Sbjct  255   SALEEYTKKLNTQ  267


>gi|59798973|sp|Q9H0K1|SN1L2_HUMAN  Serine/threonine-protein kinase SNF1-like kinase 2 (Qin-induced 
kinase)
Length=926

 Score =  385 bits (988),  Expect = 8e-107
 Identities = 200/360 (55%), Positives = 251/360 (69%), Gaps = 37/360 (10%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIKIIDK+QLD  NL+KI+REVQIMKML HPHII+LYQVMET+ M+YLVTEYA  GEI
Sbjct  45   EVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEI  104

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            FD+L  HGR+ E EARRKF QI++AV +CH R IVHRDLKAENLLLD N+NIKIADFGF 
Sbjct  105  FDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFG  164

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
            N F  G+LL TWCGSPPYAAPE+FEG++Y+GP++DIWS+GVVLYVLVCGALPFDG TL  
Sbjct  165  NFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPI  224

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            LR RVL G+FRIP+FMS                              +CEHLIR MLVLD
Sbjct  225  LRQRVLEGRFRIPYFMS-----------------------------EDCEHLIRRMLVLD  255

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKE  309
            P+KRL++ QI +HKWM +   +    R +   Q+ + E  +   NE VL  M  +G+D++
Sbjct  256  PSKRLTIAQIKEHKWMLI---EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQ  312

Query  310  QTLQSLRSDAYDHYSAIYSLLCDRHKRHKT-----LRLGALPSMPRALAFQAPVNIQPDG  364
            +T++SL++ +Y+H++AIY LL +R K H++      RL      P  +A Q     Q  G
Sbjct  313  KTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVG  372


>gi|59803093|sp|P57059|SN1L1_HUMAN  Serine/threonine-protein kinase SNF1-like kinase 1 (Serine/threonine-protein 
kinase SNF1LK)
Length=783

 Score =  348 bits (894),  Expect = 7e-96
 Identities = 173/332 (52%), Positives = 233/332 (70%), Gaps = 37/332 (11%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIKIIDKT+LD  NL+KI+REVQ+MK+L HPHII+LYQVMET+ M+Y+VTE+A  GE+
Sbjct  52   QVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEM  111

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            FD+L ++G ++E EAR+KF QI++AV +CH  +IVHRDLK ENLLLD N++IK+ADFGF 
Sbjct  112  FDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFG  171

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
            N +  G+ L TWCGSPPYAAPE+FEGKEY+GP++DIWSLGVVLYVLVCG+LPFDG  L  
Sbjct  172  NFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPT  231

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            LR RVL G+FRIPFFMS                              +CE LIR MLV+D
Sbjct  232  LRQRVLEGRFRIPFFMS-----------------------------QDCESLIRRMLVVD  262

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPL---NEDVLLAMEDMGL  306
            P +R+++ QI +H+WM+     P        C           L   +E  L  M+ +G+
Sbjct  263  PARRITIAQIRQHRWMRAEPCLPG-----PACPAFSAHSYTSNLGDYDEQALGIMQTLGV  317

Query  307  DKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHK  338
            D+++T++SL++ +Y+H++AIY LL +R K ++
Sbjct  318  DRQRTVESLQNSSYNHFAAIYYLLLERLKEYR  349


>gi|62510922|sp|Q7KZI7|MARK2_HUMAN  Serine/threonine-protein kinase MARK2 (MAP/microtubule affinity-regulating 
kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog)
Length=788

 Score =  336 bits (862),  Expect = 3e-92
 Identities = 171/321 (53%), Positives = 223/321 (69%), Gaps = 37/321 (11%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VA+KIIDKTQL+  +L+K+FREV+IMK+L HP+I++L++V+ETE+ +YLV EYASGGE+
Sbjct  78   EVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEV  137

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            FD+LVAHGRM EKEAR KF+QIV+AV +CH + IVHRDLKAENLLLDA++NIKIADFGFS
Sbjct  138  FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS  197

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
            N FT G  L T+CGSPPYAAPELF+GK+YDGP+VD+WSLGV+LY LV G+LPFDG  L+ 
Sbjct  198  NEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE  257

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            LR RVL GK+RIPF+MST                             +CE+L++  L+L+
Sbjct  258  LRERVLRGKYRIPFYMST-----------------------------DCENLLKKFLILN  288

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKE  309
            P+KR ++EQI K +WM +G  D      +      K+ R+ +         M  MG  +E
Sbjct  289  PSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTE--------LMVSMGYTRE  340

Query  310  QTLQSLRSDAYDHYSAIYSLL  330
            +   SL    Y+   A Y LL
Sbjct  341  EIQDSLVGQRYNEVMATYLLL  361


>gi|62510939|sp|Q9P0L2|MARK1_HUMAN  Serine/threonine-protein kinase MARK1 (MAP/microtubule affinity-regulating 
kinase 1)
Length=795

 Score =  332 bits (852),  Expect = 5e-91
 Identities = 174/323 (53%), Positives = 226/323 (69%), Gaps = 41/323 (12%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VA+KIIDKTQL+  +L+K+FREV+IMK+L HP+I++L++V+ETE+ +YLV EYASGGE+
Sbjct  85   EVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEV  144

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            FD+LVAHGRM EKEAR KF+QIV+AV +CH + IVHRDLKAENLLLD ++NIKIADFGFS
Sbjct  145  FDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFS  204

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
            N FT G  L T+CGSPPYAAPELF+GK+YDGP+VD+WSLGV+LY LV G+LPFDG  L+ 
Sbjct  205  NEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE  264

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            LR RVL GK+RIPF+MST                             +CE+L++ +LVL+
Sbjct  265  LRERVLRGKYRIPFYMST-----------------------------DCENLLKKLLVLN  295

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV--LLAMEDMGLD  307
            P KR S+EQI K +WM +G           E ++LK   + DP   D   +  M  MG  
Sbjct  296  PIKRGSLEQIMKDRWMNVGH----------EEEELKPYTEPDPDFNDTKRIDIMVTMGFA  345

Query  308  KEQTLQSLRSDAYDHYSAIYSLL  330
            +++   +L +  YD   A Y LL
Sbjct  346  RDEINDALINQKYDEVMATYILL  368


>gi|29840797|sp|Q96L34|MARK4_HUMAN  MAP/microtubule affinity-regulating kinase 4 (MAP/microtubule 
affinity-regulating kinase-like 1)
Length=752

 Score =  332 bits (850),  Expect = 8e-91
 Identities = 175/323 (54%), Positives = 225/323 (69%), Gaps = 41/323 (12%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIKIIDKTQL+  +L+K+FREV+IMK L HP+I++L++V+ETE+ +YLV EYAS GE+
Sbjct  84   EVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEV  143

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            FD+LV+HGRM EKEAR KF+QIV+AV++CH +NIVHRDLKAENLLLDA  NIKIADFGFS
Sbjct  144  FDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFS  203

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
            N FT G  L T+CGSPPYAAPELF+GK+YDGP+VDIWSLGV+LY LV G+LPFDG  L+ 
Sbjct  204  NEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKE  263

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            LR RVL GK+R+PF+MST                             +CE ++R  LVL+
Sbjct  264  LRERVLRGKYRVPFYMST-----------------------------DCESILRRFLVLN  294

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLK--EERQVDPLNEDVLLAMEDMGLD  307
            P KR ++EQI K KW+ +G           E ++LK   E + D  +   +  M  MG  
Sbjct  295  PAKRCTLEQIMKDKWINIG----------YEGEELKPYTEPEEDFGDTKRIEVMVGMGYT  344

Query  308  KEQTLQSLRSDAYDHYSAIYSLL  330
            +E+  +SL S  Y+  +A Y LL
Sbjct  345  REEIKESLTSQKYNEVTATYLLL  367


>gi|29337165|sp|P27448|MARK3_HUMAN  MAP/microtubule affinity-regulating kinase 3 (Cdc25C-associated 
protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein 
kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase 
STK10)
Length=776

 Score =  322 bits (826),  Expect = 5e-88
 Identities = 170/344 (49%), Positives = 225/344 (65%), Gaps = 60/344 (17%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIKIIDKTQL+  +L+K+FREV+IMK+L HP+I++L++V+ETE+ +YL+ EYASGGE+
Sbjct  81   EVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEV  140

Query  70   FDHLVAHGRMAEKEARRKFKQ-----------------------IVTAVYFCHCRNIVHR  106
            FD+LVAHGRM EKEAR KF+Q                       IV+AV +CH + IVHR
Sbjct  141  FDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHR  200

Query  107  DLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIW  166
            DLKAENLLLDA++NIKIADFGFSN FT G  L T+CGSPPYAAPELF+GK+YDGP+VD+W
Sbjct  201  DLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW  260

Query  167  SLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDK  226
            SLGV+LY LV G+LPFDG  L+ LR RVL GK+RIPF+MST                   
Sbjct  261  SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMST-------------------  301

Query  227  RLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE  286
                      +CE+L++  LVL+P KR ++EQI K +W+  G  +      +     + +
Sbjct  302  ----------DCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISD  351

Query  287  ERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLL  330
            ++++D         M  MG  +E+  +SL    YD  +A Y LL
Sbjct  352  QKRID--------IMVGMGYSQEEIQESLSKMKYDEITATYLLL  387


>gi|34395849|sp|Q8IWQ3|BRSK2_HUMAN  BR serine/threonine-protein kinase 2 (Serine/threonine-protein 
kinase 29) (SAD1B)
Length=736

 Score =  253 bits (647),  Expect = 3e-67
 Identities = 136/339 (40%), Positives = 202/339 (59%), Gaps = 31/339 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KVAIKI+++ +L E  L K+ RE+ I+K++ HPH+++L+ V E ++ +YLV E+ SGGE+
Sbjct  44   KVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL  103

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            FD+LV  GR+  KEAR+ F+QI++A+ FCH  +I HRDLK ENLLLD   NI+IADFG +
Sbjct  104  FDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMA  163

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
            +L     LL+T CGSP YA PE+  G++YDG K D+WS GV+L+ L+ GALPFD   L+ 
Sbjct  164  SLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQ  223

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            L  +V  G F +P F+                               +C+ L+R M  +D
Sbjct  224  LLEKVKRGVFHMPHFIP-----------------------------PDCQSLLRGMSEVD  254

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL--D  307
              +RL++E I KH W   G  +P  ++ I    Q++    ++ ++ DVL +M  +G   D
Sbjct  255  AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRD  314

Query  308  KEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALP  346
            + + LQ L S+  +    IY LL DR +R+ +     LP
Sbjct  315  RNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLP  353


>gi|34395684|sp|Q8TDC3|BRSK1_HUMAN  BR serine/threonine-protein kinase 1 (SAD1 kinase) (SAD1A)
Length=794

 Score =  253 bits (646),  Expect = 4e-67
 Identities = 139/341 (40%), Positives = 203/341 (59%), Gaps = 33/341 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KVAIKI+++ +L E  L K+ RE+ I+K++ HPH+++L+ V E ++ +YLV E+ SGGE+
Sbjct  75   KVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL  134

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            FD+LV  GR+  KEAR+ F+QIV+A+ FCH  +I HRDLK ENLLLD   NI+IADFG +
Sbjct  135  FDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMA  194

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
            +L     LL+T CGSP YA PE+ +G++YDG + D+WS GV+L+ L+ GALPFD   L+ 
Sbjct  195  SLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQ  254

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            L  +V  G F +P F+                               +C+ L+R M+ ++
Sbjct  255  LLEKVKRGVFHMPHFIP-----------------------------PDCQSLLRGMIEVE  285

Query  250  PNKRLSMEQICKHKWMKLG--DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL-  306
            P KRLS+EQI KH W   G  + DP  +        ++       L+ DVL +M  +G  
Sbjct  286  PEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCF  345

Query  307  -DKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALP  346
             D+E+  + LRS+  +    IY LL DR +R+ +     LP
Sbjct  346  RDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLP  386


>gi|20178276|sp|P54646|AAPK2_HUMAN  5'-AMP-activated protein kinase catalytic alpha-2 chain (AMPK 
alpha-2 chain)
Length=552

 Score =  237 bits (604),  Expect = 3e-62
 Identities = 132/334 (39%), Positives = 194/334 (58%), Gaps = 50/334 (14%)

Query  10   KVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            KVA+KI+++ ++   + + KI RE+Q +K+  HPHII+LYQV+ T    ++V EY SGGE
Sbjct  41   KVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGE  100

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            +FD++  HGR+ E EARR F+QI++AV +CH   +VHRDLK EN+LLDA++N KIADFG 
Sbjct  101  LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL  160

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
            SN+ + G+ L+T CGSP YAAPE+  G+ Y GP+VDIWS GV+LY L+CG LPFD   + 
Sbjct  161  SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP  220

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVL  248
             L  ++  G F IP +++                           S+A    L+ HML +
Sbjct  221  TLFKKIRGGVFYIPEYLNR--------------------------SVAT---LLMHMLQV  251

Query  249  DPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAME  302
            DP KR +++ I +H+W K      L   DP++D  + + + +KE               E
Sbjct  252  DPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKE-------------VCE  298

Query  303  DMGLDKEQTLQSLRS-DAYDHYSAIYSLLCDRHK  335
                 + + + SL S D  D  +  Y L+ D  +
Sbjct  299  KFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRR  332


>gi|78099208|sp|Q13131|AAPK1_HUMAN  5'-AMP-activated protein kinase catalytic alpha-1 chain (AMPK 
alpha-1 chain)
Length=550

 Score =  233 bits (594),  Expect = 4e-61
 Identities = 144/409 (35%), Positives = 214/409 (52%), Gaps = 67/409 (16%)

Query  10   KVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            KVA+KI+++ ++   + + KI RE+Q +K+  HPHII+LYQV+ T   I++V EY SGGE
Sbjct  43   KVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGE  102

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            +FD++  +GR+ EKE+RR F+QI++ V +CH   +VHRDLK EN+LLDA++N KIADFG 
Sbjct  103  LFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL  162

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
            SN+ + G+ L+T CGSP YAAPE+  G+ Y GP+VDIWS GV+LY L+CG LPFD   + 
Sbjct  163  SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVP  222

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVL  248
             L  ++  G F  P +++     LL                             +HML +
Sbjct  223  TLFKKICDGIFYTPQYLNPSVISLL-----------------------------KHMLQV  253

Query  249  DPNKRLSMEQICKHKWMK------LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAME  302
            DP KR +++ I +H+W K      L   DP++   + + + LKE               E
Sbjct  254  DPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKE-------------VCE  300

Query  303  DMGLDKEQTLQSL-RSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQ  361
                 +E+ L  L   +  D  +  Y L+ D  +     +   L + P            
Sbjct  301  KFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSP------------  348

Query  362  PDGTLNLDSDEGEEPSPEA---LVRYLSMRRHTVGVADPRTEVMEDLQK  407
            PD    LD      P PE    LV      RHT+   +P+    + ++K
Sbjct  349  PDSF--LDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRK  395


>gi|14424095|sp|O60285|NUAK1_HUMAN  NUAK family, SNF1-like kinase 1 (AMPK-related protein kinase 
5)
Length=661

 Score =  220 bits (560),  Expect = 4e-57
 Identities = 117/288 (40%), Positives = 175/288 (60%), Gaps = 37/288 (12%)

Query  1    KTPTFQFAAKV-AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY  58
            K  T +F+ +V AIK I K ++ DE+++  I RE++IM  L HPHII +Y+V E +  I 
Sbjct  70   KRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIV  129

Query  59   LVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN  118
            ++ EYAS GE++D++    R++E+E R  F+QIV+AV++CH   +VHRDLK EN+LLD N
Sbjct  130  IIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDN  189

Query  119  LNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
             NIKIADFG SNL+   + L+T+CGSP YA+PE+  G+ Y GP+VD W+LGV+LY LV G
Sbjct  190  CNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYG  249

Query  179  ALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAEC  238
             +PFDG   +NL  ++ SG++R P                                 ++ 
Sbjct  250  TMPFDGFDHKNLIRQISSGEYREP------------------------------TQPSDA  279

Query  239  EHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE  286
              LIR ML+++P++R ++E I  H W+  G     +   + +C  L +
Sbjct  280  RGLIRWMLMVNPDRRATIEDIANHWWVNWG-----YKSSVCDCDALHD  322


>gi|50400857|sp|Q14680|MELK_HUMAN  Maternal embryonic leucine zipper kinase (hMELK) (Protein kinase 
PK38) (hPK38)
Length=651

 Score =  199 bits (506),  Expect = 7e-51
 Identities = 120/335 (35%), Positives = 180/335 (53%), Gaps = 42/335 (12%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIKI+DK  L  + L +I  E++ +K L H HI +LY V+ET   I++V EY  GGE+F
Sbjct  37   VAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELF  95

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF--  128
            D++++  R++E+E R  F+QIV+AV + H +   HRDLK ENLL D    +K+ DFG   
Sbjct  96   DYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCA  155

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                     L+T CGS  YAAPEL +GK Y G + D+WS+G++LYVL+CG LPFD   + 
Sbjct  156  KPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVM  215

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVL  248
             L  +++ GK+ +P ++S     LL                             + ML +
Sbjct  216  ALYKKIMRGKYDVPKWLSPSSILLL-----------------------------QQMLQV  246

Query  249  DPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDK  308
            DP KR+SM+ +  H W+     D N+        + + +     L++D +  +     + 
Sbjct  247  DPKKRISMKNLLNHPWIM---QDYNYP------VEWQSKNPFIHLDDDCVTELSVHHRNN  297

Query  309  EQTLQSLRS-DAYDHYSAIYSLLCDRHKRHKTLRL  342
             QT++ L S   YDH +A Y LL  +  R K +RL
Sbjct  298  RQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRL  332


>gi|30316282|sp|Q9BXA7|TSSK1_HUMAN  Testis-specific serine/threonine-protein kinase 1 (TSSK-1) (Testis-specific 
kinase 1) (TSK-1) (Serine/threonine-protein kinase 
22A)
Length=367

 Score =  182 bits (461),  Expect = 1e-45
 Identities = 104/263 (39%), Positives = 152/263 (57%), Gaps = 34/263 (12%)

Query  11   VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETER-MIYLVTEYASGGE  68
            VAIKIID+ +   + L+K   RE++I+ ML H  II+ Y++ ET    +Y+V E A  G+
Sbjct  38   VAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGD  97

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            + + +   G + E EAR+KF Q+  A+ +CH  ++VHRDLK +NLLLD + NIK++DF F
Sbjct  98   LLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSF  157

Query  129  SNLFTPGQ-----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD  183
            S            L KT+CGSP YAAPE+ +G  Y     DIWSLGV+LY++VCG++P+D
Sbjct  158  SKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYD  217

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIR  243
             S ++ +    +  + R+ F  S    HL G                      EC+ LI 
Sbjct  218  DSNIKKMLR--IQKEHRVNFPRSK---HLTG----------------------ECKDLIY  250

Query  244  HMLVLDPNKRLSMEQICKHKWMK  266
            HML  D N+RL +++I  H WM+
Sbjct  251  HMLQPDVNRRLHIDEILSHCWMQ  273


>gi|9973393|sp|P57058|HUNK_HUMAN  Hormonally up-regulated neu tumor-associated kinase (Serine/threonine-protein 
kinase MAK-V) (B19)
Length=714

 Score =  172 bits (435),  Expect = 1e-42
 Identities = 114/334 (34%), Positives = 172/334 (51%), Gaps = 38/334 (11%)

Query  10   KVAIKIIDKTQLDEENL--KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
            KVAIK+IDK +  ++    K + RE QI +M+ HP+I +L  ++ETE   YLV E   GG
Sbjct  87   KVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGG  146

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
             +   +    R+ E EARR  +Q+++AV   H   +VHRDLK ENLLLD + NIK+ DFG
Sbjct  147  NLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFG  206

Query  128  FSN---LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
             SN   +        T CGSP YAAPEL   K+Y GPK+D+WS+GV +Y ++ G LPF  
Sbjct  207  LSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLPF--  263

Query  185  STLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRH  244
             T++    R L  K                   +  +N    +L  G +S       +R 
Sbjct  264  -TVEPFSLRALYQKM-----------------VDKEMNPLPTQLSTGAIS------FLRS  299

Query  245  MLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAM-ED  303
            +L  DP KR +++Q   ++W+     + N+   +           ++ L+  V+L M E 
Sbjct  300  LLEPDPVKRPNIQQALANRWL-----NENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEK  354

Query  304  MGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRH  337
            +G      + ++ S+   H  AIY LL  + +R+
Sbjct  355  LGYKNSDVINTVLSNRACHILAIYFLLNKKLERY  388


>gi|30316269|sp|Q96PF2|TSSK2_HUMAN  Testis-specific serine/threonine-protein kinase 2 (TSSK-2) (Testis-specific 
kinase 2) (TSK-2) (Serine/threonine-protein kinase 
22B) (DiGeorge syndrome protein G)
Length=358

 Score =  162 bits (410),  Expect = 9e-40
 Identities = 93/263 (35%), Positives = 151/263 (57%), Gaps = 34/263 (12%)

Query  11   VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMET-ERMIYLVTEYASGGE  68
            VA+KIID+ +   + +++   RE+ I+  + H  II+ Y++ ET +  IY++ E    G+
Sbjct  38   VAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGD  97

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            + + +   G + E  AR+ F+Q+ +AV +CH  +IVHRDLK ENLLLD + NIK++DFGF
Sbjct  98   LLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGF  157

Query  129  SNLF---TPGQLL--KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD  183
            S      + G+++  KT+CGS  YAAPE+ +   Y     DIWSLGV+LY++VCG++P+D
Sbjct  158  SKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYD  217

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIR  243
             S ++ +    +  + R+ F                    + K L        EC+ LI 
Sbjct  218  DSDIRKMLR--IQKEHRVDF-------------------PRSKNL------TCECKDLIY  250

Query  244  HMLVLDPNKRLSMEQICKHKWMK  266
             ML  D ++RL +++I  H W++
Sbjct  251  RMLQPDVSQRLHIDEILSHSWLQ  273


>gi|2499586|sp|Q16566|KCC4_HUMAN  Calcium/calmodulin-dependent protein kinase type IV (CAM kinase-GR) 
(CaMK IV)
Length=473

 Score =  161 bits (408),  Expect = 2e-39
 Identities = 104/259 (40%), Positives = 150/259 (57%), Gaps = 36/259 (13%)

Query  12   AIKIIDKTQLDEENLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K++ KT +D    KKI R E+ ++  L HP+II+L ++ ET   I LV E  +GGE+F
Sbjct  73   ALKVLKKT-VD----KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELF  127

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA---NLNIKIADFG  127
            D +V  G  +E++A    KQI+ AV + H   IVHRDLK ENLL      +  +KIADFG
Sbjct  128  DRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFG  187

Query  128  FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF-DGST  186
             S +     L+KT CG+P Y APE+  G  Y GP+VD+WS+G++ Y+L+CG  PF D   
Sbjct  188  LSKIVEHQVLMKTVCGTPGYCAPEILRGCAY-GPEVDMWSVGIITYILLCGFEPFYDERG  246

Query  187  LQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHML  246
             Q +  R+L+ ++   +F+S  +         V LNAKD               L+R ++
Sbjct  247  DQFMFRRILNCEY---YFISPWW-------DEVSLNAKD---------------LVRKLI  281

Query  247  VLDPNKRLSMEQICKHKWM  265
            VLDP KRL+  Q  +H W+
Sbjct  282  VLDPKKRLTTFQALQHPWV  300


>gi|30316270|sp|Q96PN8|TSSK3_HUMAN  Testis-specific serine/threonine-protein kinase 3 (TSSK-3) (Testis-specific 
kinase 3) (TSK-3) (Serine/threonine-protein kinase 
22C)
Length=268

 Score =  160 bits (405),  Expect = 3e-39
 Identities = 93/260 (35%), Positives = 148/260 (56%), Gaps = 33/260 (12%)

Query  10   KVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMET-ERMIYLVTEYASGG  67
            KVAIK+IDK    EE +++   RE+QI++ L H +II++Y+++E+ +  I LV E A GG
Sbjct  35   KVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLVMELAEGG  94

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
            ++FD ++  G + E  A+  F+Q+V A+ +CH   + HRDLK EN LL    N+K+ DFG
Sbjct  95   DVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQG-FNLKLTDFG  153

Query  128  FSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            F+ +      +L +T+CGS  YAAPE+ +G  +D  K D+WS+GVVLYV++C +LPFD +
Sbjct  154  FAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDT  213

Query  186  TLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHM  245
             +  +  +   G    P  +S                             A+C+ L++ +
Sbjct  214  DIPKMLWQQQKG-VSFPTHLSIS---------------------------ADCQDLLKRL  245

Query  246  LVLDPNKRLSMEQICKHKWM  265
            L  D   R S+E++  H W+
Sbjct  246  LEPDMILRPSIEEVSWHPWL  265


>gi|27805738|sp|Q9UQB9|AURKC_HUMAN  Serine/threonine-protein kinase 13 (Aurora/Ipl1/Eg2 protein 2) 
(Aurora/Ipl1-related kinase 3) (Aurora-C)
Length=309

 Score =  155 bits (393),  Expect = 8e-38
 Identities = 92/275 (33%), Positives = 146/275 (53%), Gaps = 37/275 (13%)

Query  11   VAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VA+K++ K+Q+++E L+ ++ RE++I   L HP+I+RLY      R +YL+ EYA  GE+
Sbjct  69   VALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGEL  128

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            +  L    ++ E+      +++  A+ +CH + ++HRD+K ENLLL     +KIADFG+S
Sbjct  129  YKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWS  188

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
             + TP    KT CG+  Y  PE+ EG+ YD  KVD+W +GV+ Y L+ G  PF+ ++   
Sbjct  189  -VHTPSLRRKTMCGTLDYLPPEMIEGRTYD-EKVDLWCIGVLCYELLVGYPPFESASHSE  246

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
               R+L    R P  M  G              A+D               LI  +L   
Sbjct  247  TYRRILKVDVRFPLSMPLG--------------ARD---------------LISRLLRYQ  277

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQL  284
            P +RL + QI KH W++      +  R++  C Q+
Sbjct  278  PLERLPLAQILKHPWVQ-----AHSRRVLPPCAQM  307


>gi|3122301|sp|Q14012|KCC1A_HUMAN  Calcium/calmodulin-dependent protein kinase type 1 (CaM kinase 
I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)
Length=370

 Score =  150 bits (380),  Expect = 3e-36
 Identities = 96/275 (34%), Positives = 144/275 (52%), Gaps = 33/275 (12%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK I K  L+ +    +  E+ ++  + HP+I+ L  + E+   +YL+ +  SGGE+F
Sbjct  46   VAIKCIAKEALEGKE-GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELF  104

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL---LDANLNIKIADFG  127
            D +V  G   E++A R   Q++ AV + H   IVHRDLK ENLL   LD +  I I+DFG
Sbjct  105  DRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFG  164

Query  128  FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
             S +  PG +L T CG+P Y APE+   K Y    VD WS+GV+ Y+L+CG  PF     
Sbjct  165  LSKMEDPGSVLSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDEND  223

Query  188  QNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLV  247
              L  ++L  ++       + Y+       ++  +AKD                IRH++ 
Sbjct  224  AKLFEQILKAEYE----FDSPYWD------DISDSAKD---------------FIRHLME  258

Query  248  LDPNKRLSMEQICKHKWMKLGDA--DPNFDRLIAE  280
             DP KR + EQ  +H W+  GD   D N  + ++E
Sbjct  259  KDPEKRFTCEQALQHPWI-AGDTALDKNIHQSVSE  292


>gi|67466915|sp|Q6P2M8|KCC1B_HUMAN  Calcium/calmodulin-dependent protein kinase type 1B (CaM kinase 
IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy 
up-regulated non-ubiquitously expressed CaM kinase)
Length=343

 Score =  147 bits (372),  Expect = 2e-35
 Identities = 96/271 (35%), Positives = 141/271 (52%), Gaps = 38/271 (14%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K I K  L  +    +  E+ +++ + HP+I+ L  V E+   +YL  E  +GGE+F
Sbjct  41   VALKCIPKKALRGKEAL-VENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELF  99

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA---NLNIKIADFG  127
            D ++  G   EK+A     Q++ AV + H   IVHRDLK ENLL      +  I ++DFG
Sbjct  100  DRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFG  159

Query  128  FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
             S +   G +L T CG+P Y APEL E K Y G  VD+W+LGV+ Y+L+CG  PF   + 
Sbjct  160  LSKI-QAGNMLGTACGTPGYVAPELLEQKPY-GKAVDVWALGVISYILLCGYPPFYDESD  217

Query  188  QNLRARVL--SGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHM  245
              L +++L  S +F  PF+             ++  +AKD                IRH+
Sbjct  218  PELFSQILRASYEFDSPFW------------DDISESAKD---------------FIRHL  250

Query  246  LVLDPNKRLSMEQICKHKWMKLGDADPNFDR  276
            L  DP KR + +Q  +H W+     D  FDR
Sbjct  251  LERDPQKRFTCQQALRHLWI---SGDTAFDR  278


>gi|56404610|sp|Q8IU85|KCC1D_HUMAN  Calcium/calmodulin-dependent protein kinase type 1D (CaM kinase 
ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI 
delta) (Camk1D) (CamKI-like protein kinase) (CKLiK)
Length=385

 Score =  147 bits (370),  Expect = 4e-35
 Identities = 88/257 (34%), Positives = 133/257 (51%), Gaps = 30/257 (11%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+K I K  L  +    I  E+ +++ + H +I+ L  + E+   +YLV +  SGGE+FD
Sbjct  50   AVKCIPKKALKGKE-SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFD  108

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIADFGF  128
             +V  G   EK+A    +Q++ AVY+ H   IVHRDLK ENLL    D    I I+DFG 
Sbjct  109  RIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL  168

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
            S +   G ++ T CG+P Y APE+   K Y    VD WS+GV+ Y+L+CG  PF      
Sbjct  169  SKMEGKGDVMSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDS  227

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVL  248
             L  ++L  ++       + Y+       ++  +AKD                IR+++  
Sbjct  228  KLFEQILKAEYE----FDSPYWD------DISDSAKD---------------FIRNLMEK  262

Query  249  DPNKRLSMEQICKHKWM  265
            DPNKR + EQ  +H W+
Sbjct  263  DPNKRYTCEQAARHPWI  279


>gi|62287888|sp|Q6SA08|TSSK4_HUMAN  Testis-specific serine/threonine-protein kinase 4 (TSSK-4) (Testis-specific 
kinase 4) (TSK-4) (Serine/threonine-protein kinase 
22E)
Length=328

 Score =  146 bits (369),  Expect = 5e-35
 Identities = 76/197 (38%), Positives = 115/197 (58%), Gaps = 17/197 (8%)

Query  11   VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VA+KII K +  ++ L K   RE+Q+MK+L H ++I  Y+ +E+   +Y++ E A GG++
Sbjct  51   VAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDV  110

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             + +  +G  +E  A + F Q+   + + H ++IVHRDLK ENLLLD   N+KI+DFGF+
Sbjct  111  LEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFA  170

Query  130  NLFTPGQ----------------LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY  173
             +    Q                L +T+CGS  YA PE+  G  Y+    D WS+GV+LY
Sbjct  171  KMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILY  230

Query  174  VLVCGALPFDGSTLQNL  190
             LV   LPFD + L+ L
Sbjct  231  TLVVAHLPFDDTNLKKL  247


>gi|38605718|sp|P53355|DAPK1_HUMAN  Death-associated protein kinase 1 (DAP kinase 1)
Length=1432

 Score =  144 bits (363),  Expect = 3e-34
 Identities = 97/282 (34%), Positives = 142/282 (50%), Gaps = 34/282 (12%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            K+   Q+AAK   K   K+     + + I REV I+K + HP++I L++V E +  + L+
Sbjct  33   KSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILI  92

Query  61   TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL  119
             E  +GGE+FD L     + E+EA    KQI+  VY+ H   I H DLK EN +LLD N+
Sbjct  93   LELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNV  152

Query  120  ---NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
                IKI DFG ++    G   K   G+P + APE+    E  G + D+WS+GV+ Y+L+
Sbjct  153  PKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILL  211

Query  177  CGALPFDGSTLQNLRARV--LSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLS  234
             GA PF G T Q   A V  ++ +F   +F +T               AKD         
Sbjct  212  SGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSAL------------AKD---------  250

Query  235  IAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDR  276
                   IR +LV DP KR++++   +H W+K  D      R
Sbjct  251  ------FIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSR  286


>gi|27805737|sp|Q96GD4|AURKB_HUMAN  Serine/threonine-protein kinase 12 (Aurora- and Ipl1-like midbody-associated 
protein 1) (AIM-1) (Aurora/IPL1-related kinase 
2) (Aurora-related kinase 2) (STK-1) (Aurora-B)
Length=344

 Score =  143 bits (360),  Expect = 6e-34
 Identities = 81/257 (31%), Positives = 137/257 (53%), Gaps = 32/257 (12%)

Query  11   VAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VA+K++ K+Q+++E ++ ++ RE++I   L HP+I+RLY      R IYL+ EYA  GE+
Sbjct  103  VALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGEL  162

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            +  L       E+      +++  A+ +CH + ++HRD+K ENLLL     +KIADFG+S
Sbjct  163  YKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS  222

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
             +  P    KT CG+  Y  PE+ EG+ ++  KVD+W +GV+ Y L+ G  PF+ ++   
Sbjct  223  -VHAPSLRRKTMCGTLDYLPPEMIEGRMHN-EKVDLWCIGVLCYELLVGNPPFESASHNE  280

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
               R++    + P  + TG   L+                           L+RH    +
Sbjct  281  TYRRIVKVDLKFPASVPTGAQDLISK-------------------------LLRH----N  311

Query  250  PNKRLSMEQICKHKWMK  266
            P++RL + Q+  H W++
Sbjct  312  PSERLPLAQVSAHPWVR  328


>gi|27923855|sp|O14965|STK6_HUMAN  Serine/threonine-protein kinase 6 (Serine/threonine kinase 15) 
(Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) 
(Aurora-A) (Breast-tumor-amplified kinase)
Length=403

 Score =  143 bits (360),  Expect = 6e-34
 Identities = 82/264 (31%), Positives = 138/264 (52%), Gaps = 32/264 (12%)

Query  11   VAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +A+K++ K QL++  ++ ++ REV+I   L HP+I+RLY        +YL+ EYA  G +
Sbjct  159  LALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTV  218

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            +  L    +  E+       ++  A+ +CH + ++HRD+K ENLLL +   +KIADFG+S
Sbjct  219  YRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS  278

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
             +  P     T CG+  Y  PE+ EG+ +D  KVD+WSLGV+ Y  + G  PF+ +T Q 
Sbjct  279  -VHAPSSRRTTLCGTLDYLPPEMIEGRMHD-EKVDLWSLGVLCYEFLVGKPPFEANTYQE  336

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
               R+   +F  P F++ G              A+D               LI  +L  +
Sbjct  337  TYKRISRVEFTFPDFVTEG--------------ARD---------------LISRLLKHN  367

Query  250  PNKRLSMEQICKHKWMKLGDADPN  273
            P++R  + ++ +H W+    + P+
Sbjct  368  PSQRPMLREVLEHPWITANSSKPS  391


>gi|74759724|sp|Q8IYT8|ULK2_HUMAN  Serine/threonine-protein kinase ULK2 (Unc-51-like kinase 2)
Length=1036

 Score =  138 bits (348),  Expect = 1e-32
 Identities = 74/191 (38%), Positives = 111/191 (58%), Gaps = 11/191 (5%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIK I+K  L +  +  + +E++I+K L H +I+ LY V E    ++LV EY +GG++
Sbjct  35   EVAIKSINKKNLSKSQIL-LGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDL  93

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD---------ANLN  120
             D+L A G ++E   R    QI  A+   H + I+HRDLK +N+LL          + + 
Sbjct  94   ADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIR  153

Query  121  IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL  180
            IKIADFGF+       +  T CGSP Y APE+   + YD  K D+WS+G V+Y  + G  
Sbjct  154  IKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDA-KADLWSIGTVIYQCLVGKP  212

Query  181  PFDGSTLQNLR  191
            PF  ++ Q+LR
Sbjct  213  PFQANSPQDLR  223


>gi|6685284|sp|O96017|CHK2_HUMAN  Serine/threonine-protein kinase Chk2 (Cds1)
Length=543

 Score =  138 bits (347),  Expect = 2e-32
 Identities = 94/284 (33%), Positives = 144/284 (50%), Gaps = 40/284 (14%)

Query  10   KVAIKIIDKTQL------DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            KVAIKII K +       + +    +  E++I+K L HP II++    + E   Y+V E 
Sbjct  245  KVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDY-YIVLEL  303

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLN  120
              GGE+FD +V + R+ E   +  F Q++ AV + H   I+HRDLK EN+LL   + +  
Sbjct  304  MEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCL  363

Query  121  IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELF--EGKEYDGPKVDIWSLGVVLYVLVCG  178
            IKI DFG S +     L++T CG+P Y APE+    G       VD WSLGV+L++ + G
Sbjct  364  IKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSG  423

Query  179  ALPF-DGSTLQNLRARVLSGKFR-IPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIA  236
              PF +  T  +L+ ++ SGK+  IP                V     +K L        
Sbjct  424  YPPFSEHRTQVSLKDQITSGKYNFIP---------------EVWAEVSEKAL--------  460

Query  237  ECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAE  280
                L++ +LV+DP  R + E+  +H W++  D    F  L++E
Sbjct  461  ---DLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSE  501


>gi|2833281|sp|Q16816|PHKG1_HUMAN  Phosphorylase b kinase gamma catalytic chain, skeletal muscle 
isoform (Phosphorylase kinase gamma subunit 1)
Length=387

 Score =  137 bits (346),  Expect = 2e-32
 Identities = 78/211 (36%), Positives = 121/211 (57%), Gaps = 16/211 (7%)

Query  3    PTFQFAAKVAIKIIDKT---QLDEENLKKI----FREVQIMKMLC-HPHIIRLYQVMETE  54
            PT Q   + A+K+ID T       E ++++     +EV I++ +  HP+II+L    ET 
Sbjct  41   PTSQ---EYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETN  97

Query  55   RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL  114
               +LV +    GE+FD+L     ++EKE R+  + ++  +   H  NIVHRDLK EN+L
Sbjct  98   TFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENIL  157

Query  115  LDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD-----GPKVDIWSLG  169
            LD N+NIK+ DFGFS    PG+ L+  CG+P Y APE+ E    +     G +VD+WS G
Sbjct  158  LDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTG  217

Query  170  VVLYVLVCGALPFDGSTLQNLRARVLSGKFR  200
            V++Y L+ G+ PF       +   ++SG ++
Sbjct  218  VIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQ  248


>gi|125536|sp|P15735|PHKG2_HUMAN  Phosphorylase b kinase gamma catalytic chain, testis/liver isoform 
(PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3)
Length=406

 Score =  137 bits (346),  Expect = 2e-32
 Identities = 89/267 (33%), Positives = 141/267 (52%), Gaps = 37/267 (13%)

Query  12   AIKIIDKT--QLDEENLKKIF----REVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYA  64
            A+KI++ T  +L  E L+++     RE  I++ +  HPHII L    E+   ++LV +  
Sbjct  51   AVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLM  110

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA  124
              GE+FD+L     ++EKE R   + ++ AV F H  NIVHRDLK EN+LLD N+ I+++
Sbjct  111  RKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLS  170

Query  125  DFGFSNLFTPGQLLKTWCGSPPYAAPELF-----EGKEYDGPKVDIWSLGVVLYVLVCGA  179
            DFGFS    PG+ L+  CG+P Y APE+      E     G +VD+W+ GV+L+ L+ G+
Sbjct  171  DFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGS  230

Query  180  LPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECE  239
             PF       +   ++ G+++   F S  +               D R        +  +
Sbjct  231  PPFWHRRQILMLRMIMEGQYQ---FSSPEW---------------DDR-------SSTVK  265

Query  240  HLIRHMLVLDPNKRLSMEQICKHKWMK  266
             LI  +L +DP  RL+ EQ  +H + +
Sbjct  266  DLISRLLQVDPEARLTAEQALQHPFFE  292


>gi|17379144|sp|P11801|KPSH1_HUMAN  Serine/threonine-protein kinase H1 (PSK-H1)
Length=424

 Score =  137 bits (345),  Expect = 3e-32
 Identities = 86/260 (33%), Positives = 133/260 (51%), Gaps = 35/260 (13%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            AIK+I+      E  +    E+++++ + H +II+L +V ET+  +Y+V E A+GGE+FD
Sbjct  125  AIKMIETKY--REGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFD  182

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIADFGF  128
             ++A G   E++A R  + ++  V + H   I HRDLK ENLL      +  I I DFG 
Sbjct  183  RIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGL  242

Query  129  SNLFTPGQ--LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
            ++    G   L+KT CG+P Y APE+   K Y    VD+W+LGV+ Y+L+ G +PF+   
Sbjct  243  ASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN-SVDMWALGVIAYILLSGTMPFEDDN  301

Query  187  LQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLN-AKDKRLKAGCLSIAECEHLIRHM  245
               L  ++L GK+              G     V N AKD                I  +
Sbjct  302  RTRLYRQILRGKYSYS-----------GEPWPSVSNLAKD---------------FIDRL  335

Query  246  LVLDPNKRLSMEQICKHKWM  265
            L +DP  R++  Q  +H W+
Sbjct  336  LTVDPGARMTALQALRHPWV  355


>gi|7531055|sp|O14757|CHK1_HUMAN  Serine/threonine-protein kinase Chk1
Length=476

 Score =  137 bits (345),  Expect = 3e-32
 Identities = 76/178 (42%), Positives = 108/178 (60%), Gaps = 8/178 (4%)

Query  11   VAIKIID-KTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            VA+KI+D K  +D  EN+KK   E+ I KML H ++++ Y       + YL  EY SGGE
Sbjct  35   VAVKIVDMKRAVDCPENIKK---EICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGE  91

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            +FD +     M E +A+R F Q++  V + H   I HRD+K ENLLLD   N+KI+DFG 
Sbjct  92   LFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGL  151

Query  129  SNLF---TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD  183
            + +F      +LL   CG+ PY APEL + +E+    VD+WS G+VL  ++ G LP+D
Sbjct  152  ATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWD  209


>gi|6136124|sp|O75385|ULK1_HUMAN  Serine/threonine-protein kinase ULK1 (Unc-51-like kinase 1)
Length=1050

 Score =  137 bits (344),  Expect = 4e-32
 Identities = 77/202 (38%), Positives = 114/202 (56%), Gaps = 11/202 (5%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VA+K I+K  L +     + +E++I+K L H +I+ LY   E    +YLV EY +GG++
Sbjct  42   EVAVKCINKKNLAKSQTL-LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDL  100

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD------ANLN---  120
             D+L A   ++E   R   +QI  A+   H + I+HRDLK +N+LL       AN N   
Sbjct  101  ADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIR  160

Query  121  IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL  180
            +KIADFGF+       +  T CGSP Y APE+   + YDG K D+WS+G ++Y  + G  
Sbjct  161  VKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKA  219

Query  181  PFDGSTLQNLRARVLSGKFRIP  202
            PF  S+ Q+LR      K  +P
Sbjct  220  PFQASSPQDLRLFYEKNKTLVP  241


>gi|51316189|sp|O00444|PLK4_HUMAN  Serine/threonine-protein kinase PLK4 (Polo-like kinase 4) (PLK-4) 
(Serine/threonine-protein kinase Sak) (Serine/threonine-protein 
kinase 18)
Length=970

 Score =  136 bits (343),  Expect = 5e-32
 Identities = 90/269 (33%), Positives = 135/269 (50%), Gaps = 33/269 (12%)

Query  10   KVAIKIIDKTQLDEENL-KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            +VAIK+IDK  + +  + +++  EV+I   L HP I+ LY   E    +YLV E    GE
Sbjct  37   EVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGE  96

Query  69   IFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
            +  +L    +  +E EAR    QI+T + + H   I+HRDL   NLLL  N+NIKIADFG
Sbjct  97   MNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFG  156

Query  128  F-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
              + L  P +   T CG+P Y +PE+   +   G + D+WSLG + Y L+ G  PFD  T
Sbjct  157  LATQLKMPHEKHYTLCGTPNYISPEI-ATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDT  215

Query  187  LQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHML  246
            ++N   +V+   + +P F+S              + AKD               LI  +L
Sbjct  216  VKNTLNKVVLADYEMPTFLS--------------IEAKD---------------LIHQLL  246

Query  247  VLDPNKRLSMEQICKHKWMKLGDADPNFD  275
              +P  RLS+  +  H +M    +  + D
Sbjct  247  RRNPADRLSLSSVLDHPFMSRNSSTKSKD  275


>gi|73620970|sp|Q96NX5|KCC1G_HUMAN  Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase 
IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI 
gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
Length=476

 Score =  136 bits (342),  Expect = 7e-32
 Identities = 87/259 (33%), Positives = 132/259 (50%), Gaps = 36/259 (13%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+K I K+    ++   +  E+ ++K + H +I+ L  + E+    YLV +  SGGE+FD
Sbjct  50   ALKCIKKSPAFRDS--SLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFD  107

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIADFGF  128
             ++  G   EK+A    +Q+++AV + H   IVHRDLK ENLL    + N  I I DFG 
Sbjct  108  RILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGL  167

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
            S +   G ++ T CG+P Y APE+   K Y    VD WS+GV+ Y+L+CG  PF   T  
Sbjct  168  SKMEQNG-IMSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFYEETES  225

Query  189  NLRARVLSG--KFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHML  246
             L  ++  G  +F  PF+             ++  +AKD                I H+L
Sbjct  226  KLFEKIKEGYYEFESPFW------------DDISESAKD---------------FICHLL  258

Query  247  VLDPNKRLSMEQICKHKWM  265
              DPN+R + E+   H W+
Sbjct  259  EKDPNERYTCEKALSHPWI  277


>gi|74762688|sp|Q96QS6|KPSH2_HUMAN  Serine/threonine-protein kinase H2 (PSK-H2)
Length=385

 Score =  135 bits (341),  Expect = 9e-32
 Identities = 88/276 (31%), Positives = 134/276 (48%), Gaps = 36/276 (13%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            AIK+++  +   E  +    E+ +++ + H +I++L ++ ETE  +Y+V E A+GGE+FD
Sbjct  90   AIKVMETRE--REGREACVSELSVLRRVSHRYIVQLMEIFETEDQVYMVMELATGGELFD  147

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIADFG-  127
             L+A G   E++A R  + +   + + H   I HR+LK ENLL         I I DFG 
Sbjct  148  RLIAQGSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYYHPGEESKILITDFGL  207

Query  128  -FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
             +S   +    +KT CG+P Y APE+   K Y    VD+W+LGV+ Y L+ G LPFD  +
Sbjct  208  AYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTS-AVDMWALGVITYALLSGFLPFDDES  266

Query  187  LQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHML  246
               L  ++L GK+           HL          AKD                I  +L
Sbjct  267  QTRLYRKILKGKYNYTGEPWPSISHL----------AKD---------------FIDKLL  301

Query  247  VLDPNKRLSMEQICKHKW---MKLGDADPNFDRLIA  279
            +L+   R+S  Q   H W   M  G +  N  R I+
Sbjct  302  ILEAGHRMSAGQALDHPWVITMAAGSSMKNLQRAIS  337


>gi|38604691|sp|O43293|DAPK3_HUMAN  Death-associated protein kinase 3 (DAP kinase 3) (DAP-like kinase) 
(Dlk) (ZIP-kinase)
Length=454

 Score =  135 bits (341),  Expect = 9e-32
 Identities = 90/263 (34%), Positives = 134/263 (50%), Gaps = 34/263 (12%)

Query  12   AIKIIDKTQLDEE----NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
            A K I K +L       + ++I REV I++ + HP+II L+ + E +  + L+ E  SGG
Sbjct  40   AAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGG  99

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL---NIKI  123
            E+FD L     + E EA +  KQI+  V++ H + I H DLK EN +LLD N+    IK+
Sbjct  100  ELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKL  159

Query  124  ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD  183
             DFG ++    G   K   G+P + APE+    E  G + D+WS+GV+ Y+L+ GA PF 
Sbjct  160  IDFGIAHKIEAGNEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFL  218

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIR  243
            G T Q      L+    + +     YF       N    AKD                IR
Sbjct  219  GETKQ----ETLTNISAVNYDFDEEYF------SNTSELAKD---------------FIR  253

Query  244  HMLVLDPNKRLSMEQICKHKWMK  266
             +LV DP +R+++ Q  +H W+K
Sbjct  254  RLLVKDPKRRMTIAQSLEHSWIK  276


>gi|6225242|sp|O15075|DCAK1_HUMAN  Serine/threonine-protein kinase DCAMKL1 (Doublecortin-like and 
CAM kinase-like 1)
Length=740

 Score =  134 bits (338),  Expect = 2e-31
 Identities = 100/329 (30%), Positives = 163/329 (49%), Gaps = 41/329 (12%)

Query  8    AAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
            A + A+KII K++   +    I  EV I++ + HP+I+ L + M+    +YLV E   GG
Sbjct  413  AREYALKIIKKSKCRGKE-HMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGG  471

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKI  123
            ++FD + +  +  E++A      + +A+ + H  NIVHRD+K ENLL+    D + ++K+
Sbjct  472  DLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKL  531

Query  124  ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD  183
             DFG + +      L T CG+P Y APE+     Y G KVDIW+ GV+ Y+L+CG  PF 
Sbjct  532  GDFGLATIVDGP--LYTVCGTPTYVAPEIIAETGY-GLKVDIWAAGVITYILLCGFPPFR  588

Query  184  GS--TLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHL  241
            GS    + L  ++L G+   P    + Y+       NV  +AK+               L
Sbjct  589  GSGDDQEVLFDQILMGQVDFP----SPYWD------NVSDSAKE---------------L  623

Query  242  IRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV---L  298
            I  ML++D ++R S  Q+ +H W+   D  P  +  ++   ++K+     P        +
Sbjct  624  ITMMLLVDVDQRFSAVQVLEHPWVN-DDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGV  682

Query  299  LAMEDMGLDKEQTLQSLR--SDAYDHYSA  325
              +    LDKE+ +   R   D    Y A
Sbjct  683  SVIATTALDKERQVFRRRRNQDVRSRYKA  711


>gi|1170703|sp|P31751|AKT2_HUMAN  RAC-beta serine/threonine-protein kinase (RAC-PK-beta) (Protein 
kinase Akt-2) (Protein kinase B, beta) (PKB beta)
Length=481

 Score =  134 bits (338),  Expect = 2e-31
 Identities = 94/329 (28%), Positives = 155/329 (47%), Gaps = 48/329 (14%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+ K  +  ++ +     E ++++   HP +  L    +T   +  V EYA+GGE+F
Sbjct  179  AMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELF  238

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S  129
             HL       E+ AR    +IV+A+ + H R++V+RD+K ENL+LD + +IKI DFG   
Sbjct  239  FHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCK  298

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
               + G  +KT+CG+P Y APE+ E  +Y G  VD W LGVV+Y ++CG LPF     + 
Sbjct  299  EGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHER  357

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            L   +L  + R P  +S                              E + L+  +L  D
Sbjct  358  LFELILMEEIRFPRTLS-----------------------------PEAKSLLAGLLKKD  388

Query  250  PNKRL-----SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDM  304
            P +RL       +++ +H++            L    Q + +++ + P    V   ++  
Sbjct  389  PKQRLGGGPSDAKEVMEHRFF-----------LSINWQDVVQKKLLPPFKPQVTSEVDTR  437

Query  305  GLDKEQTLQSLRSDAYDHYSAIYSLLCDR  333
              D E T QS+     D Y ++  L  D+
Sbjct  438  YFDDEFTAQSITITPPDRYDSLGLLELDQ  466


>gi|20177970|sp|Q9UQM7|KCC2A_HUMAN  Calcium/calmodulin-dependent protein kinase type II alpha chain 
(CaM-kinase II alpha chain) (CaM kinase II alpha subunit) 
(CaMK-II alpha subunit)
Length=478

 Score =  134 bits (336),  Expect = 3e-31
 Identities = 85/258 (32%), Positives = 133/258 (51%), Gaps = 30/258 (11%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A KII+  +L   + +K+ RE +I ++L HP+I+RL+  +  E   YL+ +  +GGE+F+
Sbjct  40   AAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFE  99

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFGF  128
             +VA    +E +A    +QI+ AV  CH   +VHRDLK ENLLL + L    +K+ADFG 
Sbjct  100  DIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGL  159

Query  129  S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
            +  +    Q    + G+P Y +PE+     Y G  VD+W+ GV+LY+L+ G  PF     
Sbjct  160  AIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQ  218

Query  188  QNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLV  247
              L  ++ +G +  P                V   AKD               LI  ML 
Sbjct  219  HRLYQQIKAGAYDFP----------SPEWDTVTPEAKD---------------LINKMLT  253

Query  248  LDPNKRLSMEQICKHKWM  265
            ++P+KR++  +  KH W+
Sbjct  254  INPSKRITAAEALKHPWI  271


>gi|37999482|sp|O75582|KS6A5_HUMAN  Ribosomal protein S6 kinase alpha 5 (Nuclear mitogen-and stress-activated 
protein kinase 1) (90 kDa ribosomal protein S6 
kinase 5) (RSK-like protein kinase) (RLSK)
Length=802

 Score =  133 bits (335),  Expect = 4e-31
 Identities = 98/264 (37%), Positives = 139/264 (52%), Gaps = 33/264 (12%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLC--HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+KII K    E N +K   E+  +K LC  HP+I++L++V   +   +LV E  +GGE+
Sbjct  453  AVKIISKRM--EANTQK---EITALK-LCEGHPNIVKLHEVFHDQLHTFLVMELLNGGEL  506

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIADF  126
            F+ +      +E EA    +++V+AV   H   +VHRDLK ENLL    + NL IKI DF
Sbjct  507  FERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDF  566

Query  127  GFSNLFTP-GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            GF+ L  P  Q LKT C +  YAAPEL     YD    D+WSLGV+LY ++ G +PF   
Sbjct  567  GFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ESCDLWSLGVILYTMLSGQVPFQSH  625

Query  186  TLQNLRARVLSGKFRIPFFMSTGYFHLLG-SHCNVVLNAKDKRLKAGCLSIAECEHLIRH  244
                 R+   +    I   +  G F   G +  NV   AKD               LI+ 
Sbjct  626  D----RSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD---------------LIQG  666

Query  245  MLVLDPNKRLSMEQICKHKWMKLG  268
            +L +DPNKRL M  +  ++W++ G
Sbjct  667  LLTVDPNKRLKMSGLRYNEWLQDG  690


 Score =  107 bits (267),  Expect = 3e-23
 Identities = 67/198 (33%), Positives = 105/198 (53%), Gaps = 12/198 (6%)

Query  42   PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR  101
            P ++ L+   +TE  ++L+ +Y +GGE+F HL    R  E E +    +IV A+   H  
Sbjct  112  PFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKL  171

Query  102  NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLK--TWCGSPPYAAPELFEGKEYD  159
             I++RD+K EN+LLD+N ++ + DFG S  F   +  +  ++CG+  Y AP++  G +  
Sbjct  172  GIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSG  231

Query  160  GPK-VDIWSLGVVLYVLVCGALPFDGSTLQNLRA----RVLSGKFRIPFFMSTGYFHLLG  214
              K VD WSLGV++Y L+ GA PF     +N +A    R+L  +   P  MS      L 
Sbjct  232  HDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSA-----LA  286

Query  215  SHCNVVLNAKDKRLKAGC  232
                  L  KD + + GC
Sbjct  287  KDLIQRLLMKDPKKRLGC  304


>gi|62512173|sp|Q13555|KCC2G_HUMAN  Calcium/calmodulin-dependent protein kinase type II gamma chain 
(CaM-kinase II gamma chain) (CaM kinase II gamma subunit) 
(CaMK-II gamma subunit)
Length=558

 Score =  132 bits (333),  Expect = 8e-31
 Identities = 88/269 (32%), Positives = 138/269 (51%), Gaps = 34/269 (12%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            KT T ++AAK    II+  +L   + +K+ RE +I ++L HP+I+RL+  +  E   YLV
Sbjct  34   KTSTQEYAAK----IINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV  89

Query  61   TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN  120
             +  +GGE+F+ +VA    +E +A     QI+ +V   H  +IVHRDLK ENLLL +   
Sbjct  90   FDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCK  149

Query  121  ---IKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
               +K+ADFG +  +    Q    + G+P Y +PE+     Y G  VDIW+ GV+LY+L+
Sbjct  150  GAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACGVILYILL  208

Query  177  CGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIA  236
             G  PF       L  ++ +G +  P               + V                
Sbjct  209  VGYPPFWDEDQHKLYQQIKAGAYDFP-----------SPEWDTV--------------TP  243

Query  237  ECEHLIRHMLVLDPNKRLSMEQICKHKWM  265
            E ++LI  ML ++P KR++ +Q  KH W+
Sbjct  244  EAKNLINQMLTINPAKRITADQALKHPWV  272


>gi|12643414|sp|Q13557|KCC2D_HUMAN  Calcium/calmodulin-dependent protein kinase type II delta chain 
(CaM-kinase II delta chain) (CaM kinase II delta subunit) 
(CaMK-II delta subunit)
Length=499

 Score =  132 bits (331),  Expect = 1e-30
 Identities = 89/269 (33%), Positives = 135/269 (50%), Gaps = 33/269 (12%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            K PT Q     A KII+  +L   + +K+ RE +I ++L HP+I+RL+  +  E   YLV
Sbjct  33   KIPTGQ---GYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV  89

Query  61   TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN  120
             +  +GGE+F+ +VA    +E +A    +QI+ +V  CH   IVHRDLK ENLLL +   
Sbjct  90   FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK  149

Query  121  ---IKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
               +K+ADFG +  +    Q    + G+P Y +PE+     Y G  VD+W+ GV+LY+L+
Sbjct  150  GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDMWACGVILYILL  208

Query  177  CGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIA  236
             G  PF       L  ++ +G +  P                V   AKD           
Sbjct  209  VGYPPFWDEDQHRLYQQIKAGAYDFP----------SPEWDTVTPEAKD-----------  247

Query  237  ECEHLIRHMLVLDPNKRLSMEQICKHKWM  265
                LI  ML ++P KR++  +  KH W+
Sbjct  248  ----LINKMLTINPAKRITASEALKHPWI  272


>gi|11133131|sp|Q9UK32|KS6A6_HUMAN  Ribosomal protein S6 kinase alpha 6 (S6K-alpha 6) (90 kDa ribosomal 
protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 
4) (RSK-4) (pp90RSK4)
Length=745

 Score =  131 bits (330),  Expect = 2e-30
 Identities = 93/270 (34%), Positives = 137/270 (50%), Gaps = 39/270 (14%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+KIIDK++ D     +I     +M+   HP+II L  V +  R +YLVT+   GGE+ D
Sbjct  453  AVKIIDKSKRDPSEEIEI-----LMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLD  507

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANL---NIKIADFG  127
             ++     +E+EA      I   V + HC+ +VHRDLK  N+L +D +    +I+I DFG
Sbjct  508  RILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFG  567

Query  128  FS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---D  183
            F+  L     LL T C +  + APE+   + YD    DIWSLGV+ Y ++ G  PF    
Sbjct  568  FAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDA-ACDIWSLGVLFYTMLAGYTPFANGP  626

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIR  243
              T + +  R+ +GKF +            G+  N+   AKD               L+ 
Sbjct  627  NDTPEEILLRIGNGKFSLSG----------GNWDNISDGAKD---------------LLS  661

Query  244  HMLVLDPNKRLSMEQICKHKWMKLGDADPN  273
            HML +DP++R + EQI KH W+   D  PN
Sbjct  662  HMLHMDPHQRYTAEQILKHSWITHRDQLPN  691


 Score =  107 bits (266),  Expect = 4e-23
 Identities = 67/235 (28%), Positives = 113/235 (48%), Gaps = 10/235 (4%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+K++ K  L   +  +   E  I+  + HP I++L+   +TE  +YL+ ++  GG++F 
Sbjct  103  AMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFT  162

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-N  130
             L       E++ +    ++  A+   H   IV+RDLK EN+LLD   +IK+ DFG S  
Sbjct  163  RLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKE  222

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
                 +   ++CG+  Y APE+   + +     D WS GV+++ ++ G LPF G      
Sbjct  223  SVDQEKKAYSFCGTVEYMAPEVVNRRGH-SQSADWWSYGVLMFEMLTGTLPFQGKDRNET  281

Query  191  RARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHM  245
               +L  K  +P F+S        +    +L    KR  A  L     E + RH+
Sbjct  282  MNMILKAKLGMPQFLS--------AEAQSLLRMLFKRNPANRLGSEGVEEIKRHL  328


>gi|12643413|sp|Q13554|KCC2B_HUMAN  Calcium/calmodulin-dependent protein kinase type II beta chain 
(CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II 
beta subunit)
Length=664

 Score =  131 bits (329),  Expect = 2e-30
 Identities = 84/258 (32%), Positives = 132/258 (51%), Gaps = 30/258 (11%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A KII+  +L   + +K+ RE +I ++L H +I+RL+  +  E   YLV +  +GGE+F+
Sbjct  41   AAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFE  100

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFGF  128
             +VA    +E +A    +QI+ AV  CH   +VHRDLK ENLLL +      +K+ADFG 
Sbjct  101  DIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGL  160

Query  129  S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
            +  +    Q    + G+P Y +PE+   KE  G  VDIW+ GV+LY+L+ G  PF     
Sbjct  161  AIEVQGDQQAWFGFAGTPGYLSPEVLR-KEAYGKPVDIWACGVILYILLVGYPPFWDEDQ  219

Query  188  QNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLV  247
              L  ++ +G +  P               + V                E ++LI  ML 
Sbjct  220  HKLYQQIKAGAYDFP-----------SPEWDTV--------------TPEAKNLINQMLT  254

Query  248  LDPNKRLSMEQICKHKWM  265
            ++P KR++  +  KH W+
Sbjct  255  INPAKRITAHEALKHPWV  272


>gi|38605084|sp|Q9UIK4|DAPK2_HUMAN  Death-associated protein kinase 2 (DAP kinase 2) (DAP-kinase-related 
protein 1) (DRP-1)
Length=370

 Score =  131 bits (329),  Expect = 2e-30
 Identities = 89/271 (32%), Positives = 136/271 (50%), Gaps = 34/271 (12%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            K+   ++AAK   K   +      + ++I REV I++ + H ++I L+ V E    + L+
Sbjct  43   KSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLI  102

Query  61   TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL  119
             E  SGGE+FD L     ++E+EA    KQI+  V + H + I H DLK EN +LLD N+
Sbjct  103  LELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNI  162

Query  120  ---NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
               +IK+ DFG ++    G   K   G+P + APE+    E  G + D+WS+GV+ Y+L+
Sbjct  163  PIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILL  221

Query  177  CGALPFDGSTLQNLRARV--LSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLS  234
             GA PF G T Q   A +  +S  F   FF  T               AKD         
Sbjct  222  SGASPFLGDTKQETLANITAVSYDFDEEFFSQTSEL------------AKD---------  260

Query  235  IAECEHLIRHMLVLDPNKRLSMEQICKHKWM  265
                   IR +LV +  KRL++++  +H W+
Sbjct  261  ------FIRKLLVKETRKRLTIQEALRHPWI  285


>gi|1709648|sp|P51817|PRKX_HUMAN  Serine/threonine-protein kinase PRKX (Protein kinase PKX1)
Length=358

 Score =  129 bits (325),  Expect = 6e-30
 Identities = 84/276 (30%), Positives = 137/276 (49%), Gaps = 44/276 (15%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            KT    FA KV + I D  +L +E  + +  E  ++K + HP +IRL+     ER +Y++
Sbjct  69   KTAKHFFALKV-MSIPDVIRLKQE--QHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYML  125

Query  61   TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN  120
             EY  GGE+F +L   GR +         +I+ A+ + H + IV+RDLK EN+LLD + +
Sbjct  126  MEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGH  185

Query  121  IKIADFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
            IK+ DFGF+         +TW  CG+P Y APE+ + K + G  VD W+LG++++ ++ G
Sbjct  186  IKLTDFGFAKKLVD----RTWTLCGTPEYLAPEVIQSKGH-GRAVDWWALGILIFEMLSG  240

Query  179  ALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAEC  238
              PF       +  ++L+GK   P  +    FH+                          
Sbjct  241  FPPFFDDNPFGIYQKILAGKIDFPRHLD---FHV--------------------------  271

Query  239  EHLIRHMLVLDPNKRL-----SMEQICKHKWMKLGD  269
            + LI+ +LV+D  +RL         +  H+W +  D
Sbjct  272  KDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD  307


>gi|14423930|sp|Q9UEE5|ST17A_HUMAN  Serine/threonine-protein kinase 17A (DAP kinase-related apoptosis-inducing 
protein kinase 1)
Length=414

 Score =  129 bits (324),  Expect = 8e-30
 Identities = 97/315 (30%), Positives = 154/315 (48%), Gaps = 48/315 (15%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A K + K +  ++   +I  E+ ++++   +P +I L++V ET   + LV EYA+GGEIF
Sbjct  88   AAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIF  147

Query  71   DHLVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKIAD  125
            D  VA    A  EK+ +R  +QI+  V+F H R++VH DLK +N+LL +     +IKI D
Sbjct  148  DQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVD  207

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFD  183
            FG S +    + L+   G+P Y APE+     YD      D+WS+GV+ YV++ G  PF 
Sbjct  208  FGLSRILKNSEELREIMGTPEYVAPEIL---SYDPISMATDMWSIGVLTYVMLTGISPFL  264

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIR  243
            G+  Q     +     ++    S   F +L        +A D                IR
Sbjct  265  GNDKQETFLNI----SQMNLSYSEEEFDVLSE------SAVD---------------FIR  299

Query  244  HMLVLDPNKRLSMEQICKHKWMKLGD-ADPNF--DRLIAECQQLKEERQVDPLNEDVLLA  300
             +LV  P  R + E+  KH W+      +P+F  ++ + E   L+E   V  +N D    
Sbjct  300  TLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDT---  356

Query  301  MEDMGLDKEQTLQSL  315
                  DK +T +S+
Sbjct  357  ------DKSETEESI  365


>gi|59797954|sp|Q8N568|DCAK2_HUMAN  Serine/threonine-protein kinase DCAMKL2 (Doublecortin-like and 
CAM kinase-like 2)
Length=766

 Score =  128 bits (322),  Expect = 1e-29
 Identities = 87/261 (33%), Positives = 137/261 (52%), Gaps = 37/261 (14%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KIIDK +   +E+L  I  EV I++ + HP+II L + MET   ++LV E   GG++F
Sbjct  421  ALKIIDKAKCCGKEHL--IENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLF  478

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADF  126
            D + +  +  E++       +  A+ + H  +IVHRD+K ENLL+    D   ++K+ DF
Sbjct  479  DAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDF  538

Query  127  GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF--DG  184
            G + +      L T CG+P Y APE+     Y G KVDIW+ GV+ Y+L+CG  PF  + 
Sbjct  539  GLATVVEGP--LYTVCGTPTYVAPEIIAETGY-GLKVDIWAAGVITYILLCGFPPFRSEN  595

Query  185  STLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRH  244
            +  ++L  ++L+GK   P      Y+       N+  +AK+               LI  
Sbjct  596  NLQEDLFDQILAGKLEFP----APYWD------NITDSAKE---------------LISQ  630

Query  245  MLVLDPNKRLSMEQICKHKWM  265
            ML ++   R +  QI  H W+
Sbjct  631  MLQVNVEARCTAGQILSHPWV  651


>gi|68067736|sp|Q05513|KPCZ_HUMAN  Protein kinase C zeta type (nPKC-zeta)
Length=592

 Score =  128 bits (321),  Expect = 2e-29
 Identities = 77/231 (33%), Positives = 127/231 (54%), Gaps = 16/231 (6%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K  + D+E++  +  E  + +    +P ++ L+   +T   ++LV EY +GG++
Sbjct  279  AMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDL  338

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
              H+    ++ E+ AR    +I  A+ F H R I++RDLK +N+LLDA+ +IK+ D+G  
Sbjct  339  MFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMC  398

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF------  182
                 PG    T+CG+P Y APE+  G+EY G  VD W+LGV+++ ++ G  PF      
Sbjct  399  KEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMAGRSPFDIITDN  457

Query  183  -DGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGC  232
             D +T   L   +L    RIP F+S    H+L    N     KD + + GC
Sbjct  458  PDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLN-----KDPKERLGC  503


>gi|12643943|sp|Q9Y243|AKT3_HUMAN  RAC-gamma serine/threonine-protein kinase (RAC-PK-gamma) (Protein 
kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2)
Length=479

 Score =  127 bits (320),  Expect = 2e-29
 Identities = 90/311 (28%), Positives = 144/311 (46%), Gaps = 48/311 (15%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+ K  +  ++ +     E +++K   HP +  L    +T+  +  V EY +GGE+F
Sbjct  175  AMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELF  234

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S  129
             HL      +E   R    +IV+A+ + H   IV+RDLK ENL+LD + +IKI DFG   
Sbjct  235  FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK  294

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
               T    +KT+CG+P Y APE+ E  +Y G  VD W LGVV+Y ++CG LPF     + 
Sbjct  295  EGITDAATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEK  353

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            L   +L    + P  +S                             ++ + L+  +L+ D
Sbjct  354  LFELILMEDIKFPRTLS-----------------------------SDAKSLLSGLLIKD  384

Query  250  PNKRL-----SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDM  304
            PNKRL       ++I +H +                 Q + +++ V P    V    +  
Sbjct  385  PNKRLGGGPDDAKEIMRHSFFS-----------GVNWQDVYDKKLVPPFKPQVTSETDTR  433

Query  305  GLDKEQTLQSL  315
              D+E T Q++
Sbjct  434  YFDEEFTAQTI  444


>gi|33860173|sp|P22612|KAPCG_HUMAN  cAMP-dependent protein kinase, gamma-catalytic subunit (PKA C-gamma)
Length=351

 Score =  127 bits (319),  Expect = 3e-29
 Identities = 76/223 (34%), Positives = 123/223 (55%), Gaps = 8/223 (3%)

Query  12   AIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI++K ++ + + ++ I  E +I++ +  P +++L    +    +YLV EY  GGE+F
Sbjct  71   AMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMF  130

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
              L   GR +E  A     Q+V AV + H  +++HRDLK ENLL+D    +++ DFGF+ 
Sbjct  131  SRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAK  190

Query  131  LFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                    +TW  CG+P Y APE+   K Y+   VD W+LGV++Y +  G  PF      
Sbjct  191  RVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAVGFPPFYADQPI  245

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAG  231
             +  +++SG+ R P  +S+   HLL S   V L  +   L+ G
Sbjct  246  QIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNG  288


>gi|125210|sp|P22694|KAPCB_HUMAN  cAMP-dependent protein kinase, beta-catalytic subunit (PKA C-beta)
Length=351

 Score =  127 bits (319),  Expect = 3e-29
 Identities = 78/227 (34%), Positives = 121/227 (53%), Gaps = 8/227 (3%)

Query  12   AIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+DK ++ + + ++    E +I++ +  P ++RL    +    +Y+V EY  GGE+F
Sbjct  71   AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF  130

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
             HL   GR +E  AR    QIV    + H  ++++RDLK ENLL+D    I++ DFGF+ 
Sbjct  131  SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK  190

Query  131  LFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                    +TW  CG+P Y APE+   K Y+   VD W+LGV++Y +  G  PF      
Sbjct  191  RVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPI  245

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSI  235
             +  +++SGK R P   S+    LL +   V L  +   LK G   I
Sbjct  246  QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDI  292


>gi|1730070|sp|P51812|KS6A3_HUMAN  Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal 
protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 
2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) 
(ISPK-1)
Length=740

 Score =  125 bits (315),  Expect = 9e-29
 Identities = 93/272 (34%), Positives = 141/272 (51%), Gaps = 41/272 (15%)

Query  12   AIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KIIDK++ D  E ++ + R  Q      HP+II L  V +  + +Y+VTE   GGE+ 
Sbjct  449  AVKIIDKSKRDPTEEIEILLRYGQ------HPNIITLKDVYDDGKYVYVVTELMKGGELL  502

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANLN---IKIADF  126
            D ++     +E+EA      I   V + H + +VHRDLK  N+L +D + N   I+I DF
Sbjct  503  DKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDF  562

Query  127  GFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---  182
            GF+  L     LL T C +  + APE+ + + YD    DIWSLGV+LY ++ G  PF   
Sbjct  563  GFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGVLLYTMLTGYTPFANG  621

Query  183  DGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLI  242
               T + + AR+ SGKF     +S GY++      +V   AKD               L+
Sbjct  622  PDDTPEEILARIGSGKFS----LSGGYWN------SVSDTAKD---------------LV  656

Query  243  RHMLVLDPNKRLSMEQICKHKWMKLGDADPNF  274
              ML +DP++RL+   + +H W+   D  P +
Sbjct  657  SKMLHVDPHQRLTAALVLRHPWIVHWDQLPQY  688


 Score =  108 bits (269),  Expect = 2e-23
 Identities = 58/196 (29%), Positives = 102/196 (52%), Gaps = 2/196 (1%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+K++ K  L   +  +   E  I+  + HP I++L+   +TE  +YL+ ++  GG++F 
Sbjct  98   AMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFT  157

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-N  130
             L       E++ +    ++  A+   H   I++RDLK EN+LLD   +IK+ DFG S  
Sbjct  158  RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE  217

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
                 +   ++CG+  Y APE+   + +     D WS GV+++ ++ G LPF G   +  
Sbjct  218  SIDHEKKAYSFCGTVEYMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGTLPFQGKDRKET  276

Query  191  RARVLSGKFRIPFFMS  206
               +L  K  +P F+S
Sbjct  277  MTMILKAKLGMPQFLS  292


>gi|41017453|sp|O43930|PRKY_HUMAN  Serine/threonine-protein kinase PRKY
Length=277

 Score =  125 bits (313),  Expect = 2e-28
 Identities = 73/214 (34%), Positives = 117/214 (54%), Gaps = 14/214 (6%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            KT    FA KV + I D  +  +E  + +  E  ++K + HP +IRL+     ER +Y++
Sbjct  69   KTAKHFFALKV-MSIPDVIRRKQE--QHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYML  125

Query  61   TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN  120
             EY  GGE+F +L   G  +         +I+ A+ + H + IV+RDLK EN+LLD + +
Sbjct  126  MEYVPGGELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGH  185

Query  121  IKIADFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
            IK+ DFGF+         +TW  CG+P Y APE+ + K + G  VD W+LG++++ ++ G
Sbjct  186  IKLTDFGFAKKLVD----RTWTLCGTPEYLAPEVIQSKGH-GRAVDWWALGILIFEMLSG  240

Query  179  ALPFDGSTLQNLRARVLSGKFRIP----FFMSTG  208
              PF       +  ++L+GK   P    F + TG
Sbjct  241  FPPFFDDNPFGIYQKILAGKLYFPRHLDFHVKTG  274


>gi|125205|sp|P17612|KAPCA_HUMAN  cAMP-dependent protein kinase, alpha-catalytic subunit (PKA C-alpha)
Length=351

 Score =  124 bits (312),  Expect = 2e-28
 Identities = 76/223 (34%), Positives = 120/223 (53%), Gaps = 8/223 (3%)

Query  12   AIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+DK ++ + + ++    E +I++ +  P +++L    +    +Y+V EY  GGE+F
Sbjct  71   AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF  130

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
             HL   GR +E  AR    QIV    + H  ++++RDLK ENLL+D    I++ DFGF+ 
Sbjct  131  SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK  190

Query  131  LFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                    +TW  CG+P Y APE+   K Y+   VD W+LGV++Y +  G  PF      
Sbjct  191  RVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQPI  245

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAG  231
             +  +++SGK R P   S+    LL +   V L  +   LK G
Sbjct  246  QIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNG  288


>gi|60391226|sp|P31749|AKT1_HUMAN  RAC-alpha serine/threonine-protein kinase (RAC-PK-alpha) (Protein 
kinase B) (PKB) (C-AKT)
Length=480

 Score =  124 bits (311),  Expect = 3e-28
 Identities = 73/194 (37%), Positives = 110/194 (56%), Gaps = 4/194 (2%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+ K  +  ++ +     E ++++   HP +  L    +T   +  V EYA+GGE+F
Sbjct  177  AMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELF  236

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHC-RNIVHRDLKAENLLLDANLNIKIADFGF-  128
             HL      +E  AR    +IV+A+ + H  +N+V+RDLK ENL+LD + +IKI DFG  
Sbjct  237  FHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLC  296

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                  G  +KT+CG+P Y APE+ E  +Y G  VD W LGVV+Y ++CG LPF     +
Sbjct  297  KEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHE  355

Query  189  NLRARVLSGKFRIP  202
             L   +L  + R P
Sbjct  356  KLFELILMEEIRFP  369


>gi|37999483|sp|O75676|KS6A4_HUMAN  Ribosomal protein S6 kinase alpha 4 (Nuclear mitogen-and stress-activated 
protein kinase 2) (90 kDa ribosomal protein S6 
kinase 4) (Ribosomal protein kinase B) (RSKB)
Length=772

 Score =  124 bits (311),  Expect = 3e-28
 Identities = 89/272 (32%), Positives = 140/272 (51%), Gaps = 31/272 (11%)

Query  6    QFAAKVAIKIIDKTQLDEENLKKIFREVQIMKML-CHPHIIRLYQVMETERMIYLVTEYA  64
            Q   + A+KI+ +    E N +   REV  +++   HP+++ L++V   +   YLV E  
Sbjct  432  QSGQEFAVKILSRRL--EANTQ---REVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELL  486

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR-NIVHRDLKAENLLL---DANLN  120
             GGE+ +H+      +E EA +  + +V+AV F H    +VHRDLK EN+L         
Sbjct  487  RGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP  546

Query  121  IKIADFGFSNL--FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
            +KI DFGF+ L   +PG  ++T C +  YAAPEL   + YD    D+WSLGV+LY+++ G
Sbjct  547  VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD-ESCDLWSLGVILYMMLSG  605

Query  179  ALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAEC  238
             +PF G++ Q  +++      +I      G F L G     V                E 
Sbjct  606  QVPFQGASGQGGQSQAAEIMCKI----REGRFSLDGEAWQGVSE--------------EA  647

Query  239  EHLIRHMLVLDPNKRLSMEQICKHKWMKLGDA  270
            + L+R +L +DP KRL +E +    W++ G A
Sbjct  648  KELVRGLLTVDPAKRLKLEGLRGSSWLQDGSA  679


 Score =  108 bits (270),  Expect = 2e-23
 Identities = 59/155 (38%), Positives = 88/155 (56%), Gaps = 2/155 (1%)

Query  42   PHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR  101
            P ++ L+   +T+  ++L+ +Y SGGE+F HL       E E R    +IV A+   H  
Sbjct  96   PFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKL  155

Query  102  NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKT--WCGSPPYAAPELFEGKEYD  159
             I++RDLK EN+LLD+  +I + DFG S  F   +  +T  +CG+  Y APE+   K   
Sbjct  156  GIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGH  215

Query  160  GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARV  194
            G  VD WSLG++L+ L+ GA PF     +N +A V
Sbjct  216  GKAVDWWSLGILLFELLTGASPFTLEGERNTQAEV  250


>gi|51338822|sp|Q9H4B4|PLK3_HUMAN  Serine/threonine-protein kinase PLK3 (Polo-like kinase 3) (PLK-3) 
(Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible 
kinase) (Proliferation-related kinase)
Length=646

 Score =  124 bits (310),  Expect = 4e-28
 Identities = 101/370 (27%), Positives = 161/370 (43%), Gaps = 41/370 (11%)

Query  12   AIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K+I ++++ + + + KI  E+++ + L H HI+R     E    IY+  E  S   + 
Sbjct  89   AVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLA  148

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S  129
                A   + E E R   +QI++ + + H R I+HRDLK  N  +  N+ +K+ DFG  +
Sbjct  149  HIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAA  208

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
             L  P Q  KT CG+P Y APE+   ++  GP+ D+WSLG V+Y L+CG+ PF+ + L+ 
Sbjct  209  RLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKE  267

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
                +    + +P  +S                                  L+  +L   
Sbjct  268  TYRCIKQVHYTLPASLS-----------------------------LPARQLLAAILRAS  298

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRL-IAECQQLKEERQVDPLNEDVLLAMEDMGLDK  308
            P  R S++QI +H +   G      DRL I+ C  + +    +P     L A     L  
Sbjct  299  PRDRPSIDQILRHDFFTKGYTP---DRLPISSCVTVPDLTPPNPARS--LFAKVTKSLFG  353

Query  309  EQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLR---LGALPSMPRALAFQAPVNIQPDGT  365
             +      +   D  S + S L      H+  R     A    P +L   AP +  P GT
Sbjct  354  RKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGT  413

Query  366  LNLDSDEGEE  375
            L    D  EE
Sbjct  414  LASSGDGFEE  423


>gi|1170688|sp|P41743|KPCI_HUMAN  Protein kinase C iota type (nPKC-iota) (Atypical protein kinase 
C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota)
Length=587

 Score =  123 bits (308),  Expect = 6e-28
 Identities = 74/233 (31%), Positives = 126/233 (54%), Gaps = 18/233 (7%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K  + D+E++  +  E  + +    HP ++ L+   +TE  ++ V EY +GG++
Sbjct  272  AMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDL  331

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
              H+    ++ E+ AR    +I  A+ + H R I++RDLK +N+LLD+  +IK+ D+G  
Sbjct  332  MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMC  391

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF------  182
                 PG    T+CG+P Y APE+  G++Y G  VD W+LGV+++ ++ G  PF      
Sbjct  392  KEGLRPGDTTSTFCGTPNYIAPEILRGEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSS  450

Query  183  ---DGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGC  232
               D +T   L   +L  + RIP  +S     +L S  N     KD + + GC
Sbjct  451  DNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLN-----KDPKERLGC  498


>gi|20178306|sp|Q15418|KS6A1_HUMAN  Ribosomal protein S6 kinase alpha 1 (S6K-alpha 1) (90 kDa ribosomal 
protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 
1) (RSK-1) (pp90RSK1)
Length=735

 Score =  122 bits (307),  Expect = 8e-28
 Identities = 91/271 (33%), Positives = 138/271 (50%), Gaps = 43/271 (15%)

Query  12   AIKIIDKTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K+IDK++ D  E ++ + R  Q      HP+II L  V +  + +YLVTE   GGE+ 
Sbjct  445  AVKVIDKSKRDPSEEIEILLRYGQ------HPNIITLKDVYDDGKHVYLVTELMRGGELL  498

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANLN---IKIADF  126
            D ++     +E+EA      I   V + H + +VHRDLK  N+L +D + N   ++I DF
Sbjct  499  DKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDF  558

Query  127  GFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---  182
            GF+  L     LL T C +  + APE+ + + YD    DIWSLG++LY ++ G  PF   
Sbjct  559  GFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD-EGCDIWSLGILLYTMLAGYTPFANG  617

Query  183  DGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVL-NAKDKRLKAGCLSIAECEHL  241
               T + +  R+ SGKF            L G + N V   AKD               L
Sbjct  618  PSDTPEEILTRIGSGKFT-----------LSGGNWNTVSETAKD---------------L  651

Query  242  IRHMLVLDPNKRLSMEQICKHKWMKLGDADP  272
            +  ML +DP++RL+ +Q+ +H W+   D  P
Sbjct  652  VSKMLHVDPHQRLTAKQVLQHPWVTQKDKLP  682


 Score =  108 bits (269),  Expect = 2e-23
 Identities = 57/197 (28%), Positives = 103/197 (52%), Gaps = 2/197 (1%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+K++ K  L   +  +   E  I+  + HP +++L+   +TE  +YL+ ++  GG++F 
Sbjct  92   AMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFT  151

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-N  130
             L       E++ +    ++   +   H   I++RDLK EN+LLD   +IK+ DFG S  
Sbjct  152  RLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE  211

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
                 +   ++CG+  Y APE+   ++      D WS GV+++ ++ G+LPF G   +  
Sbjct  212  AIDHEKKAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKET  270

Query  191  RARVLSGKFRIPFFMST  207
               +L  K  +P F+ST
Sbjct  271  MTLILKAKLGMPQFLST  287


>gi|27735175|sp|O14936|CSKP_HUMAN  Peripheral plasma membrane protein CASK (hCASK) (Calcium/calmodulin-dependent 
serine protein kinase) (Lin-2 homolog)
Length=926

 Score =  121 bits (304),  Expect = 2e-27
 Identities = 93/306 (30%), Positives = 148/306 (48%), Gaps = 40/306 (13%)

Query  6    QFAAKVA--IKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            QFA K+    K      L  E+LK   RE  I  ML HPHI+ L +   ++ M+Y+V E+
Sbjct  37   QFAVKIVDVAKFTSSPGLSTEDLK---REASICHMLKHPHIVELLETYSSDGMLYMVFEF  93

Query  64   ASGGEIFDHLVAHGRM----AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL  119
              G ++   +V         +E  A    +QI+ A+ +CH  NI+HRD+K   +LL +  
Sbjct  94   MDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKE  153

Query  120  N---IKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
            N   +K+  FG +  L   G +     G+P + APE+ + + Y  P VD+W  GV+L++L
Sbjct  154  NSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKP-VDVWGCGVILFIL  212

Query  176  VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSI  235
            + G LPF G T + L   ++ GK+++       + H+  S       AKD          
Sbjct  213  LSGCLPFYG-TKERLFEGIIKGKYKMN---PRQWSHISES-------AKD----------  251

Query  236  AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNE  295
                 L+R ML+LDP +R+++ +   H W+K  D       L    +QL++      L  
Sbjct  252  -----LVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKG  306

Query  296  DVLLAM  301
             VL A+
Sbjct  307  AVLAAV  312


>gi|1346538|sp|P49137|MAPK2_HUMAN  MAP kinase-activated protein kinase 2 (MAPK-activated protein 
kinase 2) (MAPKAP kinase 2) (MAPKAPK-2)
Length=400

 Score =  120 bits (302),  Expect = 3e-27
 Identities = 92/318 (28%), Positives = 148/318 (46%), Gaps = 48/318 (15%)

Query  42   PHIIRLYQVMET----ERMIYLVTEYASGGEIFDHLVAHGRMA--EKEARRKFKQIVTAV  95
            PHI+R+  V E      + + +V E   GGE+F  +   G  A  E+EA    K I  A+
Sbjct  115  PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI  174

Query  96   YFCHCRNIVHRDLKAENLLLDA---NLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPEL  152
             + H  NI HRD+K ENLL  +   N  +K+ DFGF+   T    L T C +P Y APE+
Sbjct  175  QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV  234

Query  153  FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG----STLQNLRARVLSGKFRIPFFMSTG  208
               ++YD    D+WSLGV++Y+L+CG  PF      +    ++ R+  G++  P      
Sbjct  235  LGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP------  287

Query  209  YFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG  268
                         N +   +        E + LIR++L  +P +R+++ +   H W+   
Sbjct  288  -------------NPEWSEVS------EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS  328

Query  269  DADPNFDRLIAECQQLKEERQ-VDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIY  327
               P     +   + LKE+++  + + E++  A+  M +D EQ       DA +      
Sbjct  329  TKVPQTP--LHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASN------  380

Query  328  SLLCDRHKRHKTLRLGAL  345
             LL  R K+ + L   AL
Sbjct  381  PLLLKRRKKARALEAAAL  398


>gi|41017502|sp|Q96RG2|PASK_HUMAN  PAS domain-containing serine/threonine-protein kinase (PAS-kinase) 
(PASKIN) (hPASK)
Length=1323

 Score =  120 bits (301),  Expect = 4e-27
 Identities = 60/170 (35%), Positives = 102/170 (60%), Gaps = 1/170 (0%)

Query  14    KIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE-YASGGEIFDH  72
             K+++   +++  L K+  E+ I+  + H +II++  + E +    LV E + SG ++F  
Sbjct  1034  KVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAF  1093

Query  73    LVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF  132
             +  H R+ E  A   F+Q+V+AV +   ++I+HRD+K EN+++  +  IK+ DFG +   
Sbjct  1094  IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYL  1153

Query  133   TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
               G+L  T+CG+  Y APE+  G  Y GP++++WSLGV LY LV    PF
Sbjct  1154  ERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF  1203


>gi|6226833|sp|Q13237|KGP2_HUMAN  cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II cGMP-dependent 
protein kinase)
Length=762

 Score =  119 bits (299),  Expect = 7e-27
 Identities = 66/193 (34%), Positives = 106/193 (54%), Gaps = 2/193 (1%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K I K  + D +  + ++ E +I++ LC P I++LY+  +  + +Y++ E   GGE++
Sbjct  480  AMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELW  539

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
              L   G   E  ++     +  A  + H   I++RDLK ENL+LDA   +K+ DFGF+ 
Sbjct  540  SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK  599

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
                GQ   T+CG+P Y APE+   K +D   VD WSLG+++Y L+ G  PF G      
Sbjct  600  KIGSGQKTWTFCGTPEYVAPEVILNKGHDF-SVDFWSLGILVYELLTGNPPFSGVDQMMT  658

Query  191  RARVLSGKFRIPF  203
               +L G  ++ F
Sbjct  659  YNLILKGIEKMDF  671


>gi|6166243|sp|Q15349|KS6A2_HUMAN  Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal 
protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 
3) (RSK-3) (pp90RSK3)
Length=733

 Score =  119 bits (298),  Expect = 9e-27
 Identities = 82/263 (31%), Positives = 133/263 (50%), Gaps = 41/263 (15%)

Query  12   AIKIIDKTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KIIDK++ D  E ++ + R  Q      HP+II L  V +  + +YLV E   GGE+ 
Sbjct  442  AVKIIDKSKRDPSEEIEILLRYGQ------HPNIITLKDVYDDGKFVYLVMELMRGGELL  495

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADF  126
            D ++     +E+EA      I   + + H + +VHRDLK  N+L      +  +I++ DF
Sbjct  496  DRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDF  555

Query  127  GFSNLFTPGQ-LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---  182
            GF+     G  LL T C +  + APE+ + + YD    DIWSLG++LY ++ G  PF   
Sbjct  556  GFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGILLYTMLAGFTPFANG  614

Query  183  DGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLI  242
               T + + AR+ SGK+            L G + + + +A               + ++
Sbjct  615  PDDTPEEILARIGSGKYA-----------LSGGNWDSISDA--------------AKDVV  649

Query  243  RHMLVLDPNKRLSMEQICKHKWM  265
              ML +DP++RL+  Q+ KH W+
Sbjct  650  SKMLHVDPHQRLTAMQVLKHPWV  672


 Score =  110 bits (276),  Expect = 3e-24
 Identities = 60/196 (30%), Positives = 104/196 (53%), Gaps = 2/196 (1%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+K++ K  L   +  +   E  I+  + HP I++L+   +TE  +YL+ ++  GG++F 
Sbjct  89   AMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFT  148

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-N  130
             L       E++ +    ++  A+   H   I++RDLK EN+LLD   +IKI DFG S  
Sbjct  149  RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE  208

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
                 +   ++CG+  Y APE+   + +     D WS GV+++ ++ G+LPF G   +  
Sbjct  209  AIDHDKRAYSFCGTIEYMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGSLPFQGKDRKET  267

Query  191  RARVLSGKFRIPFFMS  206
             A +L  K  +P F+S
Sbjct  268  MALILKAKLGMPQFLS  283


>gi|74762148|sp|Q16644|MAPK3_HUMAN  MAP kinase-activated protein kinase 3 (MAPK-activated protein 
kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) 
(3pK)
Length=382

 Score =  119 bits (297),  Expect = 1e-26
 Identities = 85/282 (30%), Positives = 136/282 (48%), Gaps = 41/282 (14%)

Query  42   PHIIRLYQVMET----ERMIYLVTEYASGGEIFDHLVAHGRMA--EKEARRKFKQIVTAV  95
            PHI+ +  V E     +R + ++ E   GGE+F  +   G  A  E+EA    + I TA+
Sbjct  95   PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI  154

Query  96   YFCHCRNIVHRDLKAENLLL---DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPEL  152
             F H  NI HRD+K ENLL    + +  +K+ DFGF+   T    L+T C +P Y APE+
Sbjct  155  QFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEV  213

Query  153  FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ----NLRARVLSGKFRIPFFMSTG  208
               ++YD    D+WSLGV++Y+L+CG  PF  +T Q     ++ R+  G++  P      
Sbjct  214  LGPEKYD-KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFP------  266

Query  209  YFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG  268
                         N +   +        + + LIR +L  DP +RL++ Q   H W+   
Sbjct  267  -------------NPEWSEVS------EDAKQLIRLLLKTDPTERLTITQFMNHPWINQS  307

Query  269  DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ  310
               P      A   Q +++   D + E++  A+  M +D +Q
Sbjct  308  MVVPQTPLHTARVLQ-EDKDHWDEVKEEMTSALATMRVDYDQ  348


>gi|22096374|sp|Q9NYY3|PLK2_HUMAN  Serine/threonine-protein kinase PLK2 (Polo-like kinase 1) (PLK-2) 
(Serine/threonine-protein kinase SNK) (Serum-inducible 
kinase)
Length=685

 Score =  117 bits (294),  Expect = 3e-26
 Identities = 75/272 (27%), Positives = 133/272 (48%), Gaps = 35/272 (12%)

Query  12   AIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A KII  +++ + + + KI +E+++ ++L H H+++ Y   E +  IY++ EY S   + 
Sbjct  109  AAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMA  168

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
              L A   + E E R   +QIV+ + + H + I+HRDLK  N  ++  + +K+ DFG + 
Sbjct  169  HILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAA  228

Query  131  LFTP-GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
               P     +T CG+P Y +PE+   K+  G + DIW+LG V+Y ++ G  PF+ + L+ 
Sbjct  229  RLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKE  287

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
                +   ++ +P  +                             +A  +HLI  ML  +
Sbjct  288  TYRCIREARYTMPSSL-----------------------------LAPAKHLIASMLSKN  318

Query  250  PNKRLSMEQICKHKWMKLGDADPNFDRLIAEC  281
            P  R S++ I +H +   G      DRL + C
Sbjct  319  PEDRPSLDDIIRHDFFLQGFTP---DRLSSSC  347


>gi|34098463|sp|Q86SG6|NEK8_HUMAN  Serine/threonine-protein kinase Nek8 (NimA-related protein kinase 
8) (NIMA-related kinase 12a)
Length=692

 Score =  116 bits (291),  Expect = 6e-26
 Identities = 68/192 (35%), Positives = 107/192 (55%), Gaps = 4/192 (2%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            V IK I   Q+ +E  +    E Q++K+L HP++I  Y+    ++ + +  EYA GG + 
Sbjct  30   VIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLA  89

Query  71   DHLV--AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN-LNIKIADFG  127
            + +    +  + E+     F QI+ A++  H   I+HRDLK +N+LLD + + +KI DFG
Sbjct  90   EFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFG  149

Query  128  FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
             S + +      T  G+P Y +PEL EGK Y+  K DIW+LG VLY L      F+ + L
Sbjct  150  ISKILSSKSKAYTVVGTPCYISPELCEGKPYN-QKSDIWALGCVLYELASLKRAFEAANL  208

Query  188  QNLRARVLSGKF  199
              L  +++SG F
Sbjct  209  PALVLKIMSGTF  220


>gi|28558166|sp|Q9HBY8|SGK2_HUMAN  Serine/threonine-protein kinase Sgk2 (Serum/glucocorticoid regulated 
kinase 2)
Length=427

 Score =  115 bits (289),  Expect = 1e-25
 Identities = 73/223 (32%), Positives = 112/223 (50%), Gaps = 9/223 (4%)

Query  12   AIKIIDKTQ-LDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K   L ++    I  E  ++ K + HP ++ L    +T   +Y V +Y +GGE+
Sbjct  122  AVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGEL  181

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
            F HL    R  E  AR    ++ +A+ + H  NI++RDLK EN+LLD   ++ + DFG  
Sbjct  182  FFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLC  241

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                 P     T+CG+P Y APE+   + YD   VD W LG VLY ++ G  PF    + 
Sbjct  242  KEGVEPEDTTSTFCGTPEYLAPEVLRKEPYD-RAVDWWCLGAVLYEMLHGLPPFYSQDVS  300

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAG  231
             +   +L    +IP   +     LL S     L  KD+R + G
Sbjct  301  QMYENILHQPLQIPGGRTVAACDLLQS-----LLHKDQRQRLG  338


>gi|462455|sp|P05129|KPCG_HUMAN  Protein kinase C gamma type (PKC-gamma)
Length=697

 Score =  115 bits (288),  Expect = 1e-25
 Identities = 62/168 (36%), Positives = 95/168 (56%), Gaps = 5/168 (2%)

Query  42   PHII-RLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC  100
            PH + +L+   +T   +Y V EY +GG++  H+   G+  E  A     +I   ++F H 
Sbjct  414  PHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHN  473

Query  101  RNIVHRDLKAENLLLDANLNIKIADFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEY  158
            + I++RDLK +N++LDA  +IKI DFG    N+F PG   +T+CG+P Y APE+   + Y
Sbjct  474  QGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVF-PGTTTRTFCGTPDYIAPEIIAYQPY  532

Query  159  DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMS  206
             G  VD WS GV+LY ++ G  PFDG   + L   ++      P  +S
Sbjct  533  -GKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLS  579


>gi|400135|sp|Q02156|KPCE_HUMAN  Protein kinase C epsilon type (nPKC-epsilon)
Length=737

 Score =  115 bits (288),  Expect = 1e-25
 Identities = 68/235 (28%), Positives = 123/235 (52%), Gaps = 9/235 (3%)

Query  12   AIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K   L ++++     E +I+ +   HP++ +LY   +T+  ++ V EY +GG++
Sbjct  435  AVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDL  494

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
               +    +  E  +R    ++ +A+ F H   +++RDLK +N+LLDA  + K+ADFG  
Sbjct  495  MFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMC  554

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                  G    T+CG+P Y APE+ +  EY GP VD W+LGV++Y ++ G  PF+     
Sbjct  555  KEGILNGVTTTTFCGTPDYIAPEILQELEY-GPSVDWWALGVLMYEMMAGQPPFEADNED  613

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIR  243
            +L   +L      P ++S     +L +        K+   + GC++    E  I+
Sbjct  614  DLFESILHDDVLYPVWLSKEAVSILKA-----FMTKNPHKRLGCVASQNGEDAIK  663


>gi|1346393|sp|P24723|KPCL_HUMAN  Protein kinase C eta type (nPKC-eta) (PKC-L)
Length=682

 Score =  115 bits (288),  Expect = 1e-25
 Identities = 70/236 (29%), Positives = 126/236 (53%), Gaps = 9/236 (3%)

Query  12   AIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K   L +++++    E +I+ +   HP + +L+   +T   ++ V E+ +GG++
Sbjct  381  AVKVLKKDVILLDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDL  440

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
              H+    R  E  AR    +I++A+ F H + I++RDLK +N+LLD   + K+ADFG  
Sbjct  441  MFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMC  500

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                  G    T+CG+P Y APE+ +   Y GP VD W++GV+LY ++CG  PF+     
Sbjct  501  KEGICNGVTTATFCGTPDYIAPEILQEMLY-GPAVDWWAMGVLLYEMLCGHAPFEAENED  559

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRH  244
            +L   +L+ +   P ++      +L S        K+  ++ G L+      ++RH
Sbjct  560  DLFEAILNDEVVYPTWLHEDATGILKS-----FMTKNPTMRLGSLTQGGEHAILRH  610


>gi|3024670|sp|Q15831|STK11_HUMAN  Serine/threonine-protein kinase 11 (Serine/threonine-protein 
kinase LKB1)
Length=433

 Score =  113 bits (283),  Expect = 5e-25
 Identities = 83/268 (30%), Positives = 128/268 (47%), Gaps = 46/268 (17%)

Query  12   AIKIIDKTQL-----DEENLKKIFREVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYA  64
            A+KI+ K +L      E N+KK   E+Q+++ L H ++I+L  V+  E ++ +Y+V EY 
Sbjct  76   AVKILKKKKLRRIPNGEANVKK---EIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYC  132

Query  65   SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK  122
              G  E+ D  V   R    +A   F Q++  + + H + IVH+D+K  NLLL     +K
Sbjct  133  VCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLK  191

Query  123  IADFGFSNLFTP---GQLLKTWCGSPPYAAPELFEGKE-YDGPKVDIWSLGVVLYVLVCG  178
            I+D G +    P       +T  GSP +  PE+  G + + G KVDIWS GV LY +  G
Sbjct  192  ISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTG  251

Query  179  ALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAEC  238
              PF+G  +  L   +  G + IP              C   L+                
Sbjct  252  LYPFEGDNIYKLFENIGKGSYAIP------------GDCGPPLS----------------  283

Query  239  EHLIRHMLVLDPNKRLSMEQICKHKWMK  266
              L++ ML  +P KR S+ QI +H W +
Sbjct  284  -DLLKGMLEYEPAKRFSIRQIRQHSWFR  310


>gi|125549|sp|P17252|KPCA_HUMAN  Protein kinase C alpha type (PKC-alpha) (PKC-A)
Length=672

 Score =  113 bits (282),  Expect = 6e-25
 Identities = 65/198 (32%), Positives = 109/198 (55%), Gaps = 4/198 (2%)

Query  12   AIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHII-RLYQVMETERMIYLVTEYASGGEI  69
            AIKI+ K   + +++++    E +++ +L  P  + +L+   +T   +Y V EY +GG++
Sbjct  366  AIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL  425

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
              H+   G+  E +A     +I   ++F H R I++RDLK +N++LD+  +IKIADFG  
Sbjct  426  MYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMC  485

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                  G   +T+CG+P Y APE+   + Y G  VD W+ GV+LY ++ G  PFDG    
Sbjct  486  KEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDED  544

Query  189  NLRARVLSGKFRIPFFMS  206
             L   ++      P  +S
Sbjct  545  ELFQSIMEHNVSYPKSLS  562


>gi|56404656|sp|Q96RR4|KKCC2_HUMAN  Calcium/calmodulin-dependent protein kinase kinase 2 (Calcium/calmodulin-dependent 
protein kinase kinase beta) (CaM-kinase 
kinase beta) (CaM-KK beta) (CaMKK beta)
Length=588

 Score =  112 bits (281),  Expect = 8e-25
 Identities = 71/252 (28%), Positives = 126/252 (50%), Gaps = 33/252 (13%)

Query  26   LKKIFREVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKE  83
            ++++++E+ I+K L HP++++L +V++   E  +Y+V E  + G + + +     ++E +
Sbjct  230  IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQ  288

Query  84   ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ-LLKTWC  142
            AR  F+ ++  + + H + I+HRD+K  NLL+  + +IKIADFG SN F     LL    
Sbjct  289  ARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTV  348

Query  143  GSPPYAAPELFE--GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR  200
            G+P + APE      K + G  +D+W++GV LY  V G  PF    +  L +++ S    
Sbjct  349  GTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALE  408

Query  201  IPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQIC  260
             P               ++  + KD               LI  ML  +P  R+ + +I 
Sbjct  409  FP------------DQPDIAEDLKD---------------LITRMLDKNPESRIVVPEIK  441

Query  261  KHKWMKLGDADP  272
             H W+    A+P
Sbjct  442  LHPWVTRHGAEP  453


>gi|1709658|sp|P53350|PLK1_HUMAN  Serine/threonine-protein kinase PLK1 (Polo-like kinase 1) (PLK-1) 
(Serine/threonine-protein kinase 13) (STPK13)
Length=603

 Score =  111 bits (278),  Expect = 2e-24
 Identities = 62/197 (31%), Positives = 101/197 (51%), Gaps = 5/197 (2%)

Query  7    FAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG  66
            FA K+  K +    L     +K+  E+ I + L H H++  +   E    +++V E    
Sbjct  79   FAGKIVPKSL---LLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRR  135

Query  67   GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF  126
              + +       + E EAR   +QIV    + H   ++HRDLK  NL L+ +L +KI DF
Sbjct  136  RSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDF  195

Query  127  GF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            G  + +   G+  KT CG+P Y APE+   K +   +VD+WS+G ++Y L+ G  PF+ S
Sbjct  196  GLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSF-EVDVWSIGCIMYTLLVGKPPFETS  254

Query  186  TLQNLRARVLSGKFRIP  202
             L+    R+   ++ IP
Sbjct  255  CLKETYLRIKKNEYSIP  271


>gi|125379|sp|P14619|KGP1B_HUMAN  cGMP-dependent protein kinase 1, beta isozyme (cGK 1 beta) (cGKI-beta)
Length=686

 Score =  110 bits (275),  Expect = 4e-24
 Identities = 66/193 (34%), Positives = 100/193 (51%), Gaps = 2/193 (1%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+ K  + D    + I  E QIM+      I+RLY+  +  + +Y++ E   GGE++
Sbjct  403  AMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELW  462

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
              L   G   +   R     +V A  + H + I++RDLK ENL+LD     K+ DFGF+ 
Sbjct  463  TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK  522

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
                G+   T+CG+P Y APE+   K +D    D WSLG+++Y L+ G+ PF G      
Sbjct  523  KIGFGKKTWTFCGTPEYVAPEIILNKGHD-ISADYWSLGILMYELLTGSPPFSGPDPMKT  581

Query  191  RARVLSGKFRIPF  203
               +L G   I F
Sbjct  582  YNIILRGIDMIEF  594


>gi|6225588|sp|Q13976|KGP1A_HUMAN  cGMP-dependent protein kinase 1, alpha isozyme (CGK 1 alpha) 
(cGKI-alpha)
Length=671

 Score =  110 bits (275),  Expect = 4e-24
 Identities = 66/193 (34%), Positives = 100/193 (51%), Gaps = 2/193 (1%)

Query  12   AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+ K  + D    + I  E QIM+      I+RLY+  +  + +Y++ E   GGE++
Sbjct  388  AMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELW  447

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
              L   G   +   R     +V A  + H + I++RDLK ENL+LD     K+ DFGF+ 
Sbjct  448  TILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK  507

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
                G+   T+CG+P Y APE+   K +D    D WSLG+++Y L+ G+ PF G      
Sbjct  508  KIGFGKKTWTFCGTPEYVAPEIILNKGHD-ISADYWSLGILMYELLTGSPPFSGPDPMKT  566

Query  191  RARVLSGKFRIPF  203
               +L G   I F
Sbjct  567  YNIILRGIDMIEF  579


>gi|24211884|sp|Q9H1R3|MYLK2_HUMAN  Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2)
Length=596

 Score =  110 bits (274),  Expect = 5e-24
 Identities = 76/262 (29%), Positives = 121/262 (46%), Gaps = 37/262 (14%)

Query  10   KVAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            K+A K+I K T  D+E    +  E+++M  L H ++I+LY  +ET   I L  EY  GGE
Sbjct  310  KLAAKVIKKQTPKDKE---MVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGE  366

Query  69   IFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN--IKIAD  125
            +F+ +V     + E +     +QI   + F H   ++H DLK EN+L        +KI D
Sbjct  367  LFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIID  426

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFD  183
            FG +  + P + LK   G+P + +PE+     YD    K D+WS+GV+ Y+L+ G  PF 
Sbjct  427  FGLARRYNPNEKLKVNFGTPEFLSPEVV---NYDQISDKTDMWSMGVITYMLLSGLSPFL  483

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIR  243
            G         VLSG     ++     F  +                       E +  + 
Sbjct  484  GDDDTETLNNVLSGN----WYFDEETFEAVSD---------------------EAKDFVS  518

Query  244  HMLVLDPNKRLSMEQICKHKWM  265
            +++V D   R++  Q   H W+
Sbjct  519  NLIVKDQRARMNAAQCLAHPWL  540


>gi|1709252|sp|P51955|NEK2_HUMAN  Serine/threonine-protein kinase Nek2 (NimA-related protein kinase 
2) (NimA-like protein kinase 1) (HSPK 21)
Length=445

 Score =  110 bits (274),  Expect = 5e-24
 Identities = 109/416 (26%), Positives = 184/416 (44%), Gaps = 42/416 (10%)

Query  14   KIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQ--VMETERMIYLVTEYASGGEIFD  71
            K +D   + E   + +  EV +++ L HP+I+R Y   +  T   +Y+V EY  GG++  
Sbjct  37   KELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLAS  96

Query  72   HLVAHGR----MAEKEARRKFKQIVTAVYFCHCRN-----IVHRDLKAENLLLDANLNIK  122
             +    +    + E+   R   Q+  A+  CH R+     ++HRDLK  N+ LD   N+K
Sbjct  97   VITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVK  156

Query  123  IADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP  181
            + DFG + +        KT+ G+P Y +PE      Y+  K DIWSLG +LY L     P
Sbjct  157  LGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYN-EKSDIWSLGCLLYELCALMPP  215

Query  182  FDGSTLQNLRARVLSGKF-RIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEH  240
            F   + + L  ++  GKF RIP+     Y   L      +LN KD    +        E 
Sbjct  216  FTAFSQKELAGKIREGKFRRIPY----RYSDELNEIITRMLNLKDYHRPS-------VEE  264

Query  241  LIRHMLVLD---PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV  297
            ++ + L+ D     +R ++E+    +  +LG+ + + D      +   +E Q+    E  
Sbjct  265  ILENPLIADLVADEQRRNLER----RGRQLGEPEKSQDSSPVLSELKLKEIQLQE-RERA  319

Query  298  LLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRH--KRHKTLRLGALPSMPR--ALA  353
            L A E+    KEQ L      A D  +   +LL +    K  K L L + P +    +  
Sbjct  320  LKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSV  379

Query  354  FQAPVNIQPDGTLNLDSDEGEEP--SPEALVRYLSMRRHTVGVADPRTEVMEDLQK  407
             +  V+   +   N+   E  E   + ++  + L  R H    A  R + + D++K
Sbjct  380  IKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLH---AAQLRAQALSDIEK  432


>gi|20138711|sp|Q9BZL6|KPCD2_HUMAN  Protein kinase D2 (nPKC-D2)
Length=878

 Score =  110 bits (274),  Expect = 5e-24
 Identities = 73/261 (27%), Positives = 135/261 (51%), Gaps = 34/261 (13%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K+IDK +   +   ++  EV I++ L HP I+ L  + ET   +++V E    G++ 
Sbjct  577  VAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLH-GDML  635

Query  71   DHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIAD  125
            + +++   GR+ E+  +    QI+ A+   H +NIVH DLK EN+LL   D    +K+ D
Sbjct  636  EMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCD  695

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            FGF+ +       ++  G+P Y APE+   + Y+   +D+WS+GV++YV + G  PF+  
Sbjct  696  FGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYN-RSLDMWSVGVIMYVSLSGTFPFNED  754

Query  186  TLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHM  245
              +++  ++ +  F  P   ++ + H                + AG +       LI ++
Sbjct  755  --EDINDQIQNAAFMYP---ASPWSH----------------ISAGAID------LINNL  787

Query  246  LVLDPNKRLSMEQICKHKWMK  266
            L +   KR S+++   H W++
Sbjct  788  LQVKMRKRYSVDKSLSHPWLQ  808


>gi|12644418|sp|Q15746|MYLK_HUMAN  Myosin light chain kinase, smooth muscle and non-muscle isozymes 
(MLCK) [Contains: Telokin (Kinase-related protein) (KRP)]
Length=1914

 Score =  109 bits (273),  Expect = 7e-24
 Identities = 83/302 (27%), Positives = 137/302 (45%), Gaps = 30/302 (9%)

Query  22    DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHG-RMA  80
             ++EN+++   E+ IM  L HP +++     E +  I +V E  SGGE+F+ ++     + 
Sbjct  1502  EKENIRQ---EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELT  1558

Query  81    EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLL  138
             E+E  +  +QI   V + H + IVH DLK EN++        IK+ DFG +        L
Sbjct  1559  ERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSL  1618

Query  139   KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGK  198
             K   G+P + APE+    E  G   D+WS+GV+ Y+LV G  PF G       A V S  
Sbjct  1619  KVLFGTPEFVAPEVI-NYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSAT  1677

Query  199   FRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ  258
             +    F    +  +     + + N   K +K    +  +C   ++H  ++   K +  ++
Sbjct  1678  WD---FDDEAFDEISDDAKDFISNLLKKDMK----NRLDCTQCLQHPWLMKDTKNMEAKK  1730

Query  259   ICK---------HKWMKLGDADPNFDRL--IAECQQLKEERQ-----VDPLNEDVLLAME  302
             + K          KW K G+A     RL  +A    L   +        PLN + L + E
Sbjct  1731  LSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEE  1790

Query  303   DM  304
             D+
Sbjct  1791  DV  1792


>gi|20141488|sp|P05771|KPCB_HUMAN  Protein kinase C beta type (PKC-beta) (PKC-B)
Length=671

 Score =  109 bits (273),  Expect = 7e-24
 Identities = 64/199 (32%), Positives = 109/199 (54%), Gaps = 6/199 (3%)

Query  12   AIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHII-RLYQVMETERMIYLVTEYASGGEI  69
            A+KI+ K   + +++++    E +++ +   P  + +L+   +T   +Y V EY +GG++
Sbjct  369  AVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDL  428

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
              H+   GR  E  A     +I   ++F   + I++RDLK +N++LD+  +IKIADFG  
Sbjct  429  MYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMC  488

Query  129  -SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
              N++  G   KT+CG+P Y APE+   + Y G  VD W+ GV+LY ++ G  PF+G   
Sbjct  489  KENIW-DGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDE  546

Query  188  QNLRARVLSGKFRIPFFMS  206
              L   ++      P  MS
Sbjct  547  DELFQSIMEHNVAYPKSMS  565


>gi|3914977|sp|O00141|SGK1_HUMAN  Serine/threonine-protein kinase Sgk1 (Serum/glucocorticoid-regulated 
kinase 1)
Length=431

 Score =  108 bits (271),  Expect = 1e-23
 Identities = 68/205 (33%), Positives = 106/205 (51%), Gaps = 4/205 (1%)

Query  12   AIKIIDKTQ-LDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K   L ++  K I  E  ++ K + HP ++ L+   +T   +Y V +Y +GGE+
Sbjct  125  AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL  184

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
            F HL       E  AR    +I +A+ + H  NIV+RDLK EN+LLD+  +I + DFG  
Sbjct  185  FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLC  244

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                       T+CG+P Y APE+   + YD   VD W LG VLY ++ G  PF      
Sbjct  245  KENIEHNSTTSTFCGTPEYLAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTA  303

Query  189  NLRARVLSGKFRIPFFMSTGYFHLL  213
             +   +L+   ++   ++    HLL
Sbjct  304  EMYDNILNKPLQLKPNITNSARHLL  328


>gi|22256934|sp|Q96PY6|NEK1_HUMAN  Serine/threonine-protein kinase Nek1 (NimA-related protein kinase 
1) (NY-REN-55 antigen)
Length=1258

 Score =  108 bits (271),  Expect = 1e-23
 Identities = 61/190 (32%), Positives = 109/190 (57%), Gaps = 4/190 (2%)

Query  13   IKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDH  72
            IK I+ +++  +  ++  REV ++  + HP+I++  +  E    +Y+V +Y  GG++F  
Sbjct  32   IKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKR  91

Query  73   LVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            + A   +   E +    F QI  A+   H R I+HRD+K++N+ L  +  +++ DFG + 
Sbjct  92   INAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIAR  151

Query  131  -LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
             L +  +L +T  G+P Y +PE+ E K Y+  K DIW+LG VLY L      F+  +++N
Sbjct  152  VLNSTVELARTCIGTPYYLSPEICENKPYNN-KSDIWALGCVLYELCTLKHAFEAGSMKN  210

Query  190  LRARVLSGKF  199
            L  +++SG F
Sbjct  211  LVLKIISGSF  220


>gi|2499575|sp|Q15139|KPCD1_HUMAN  Protein kinase D1 (nPKC-D1) (Protein kinase D) (Protein kinase 
C mu type) (nPKC-mu)
Length=912

 Score =  108 bits (270),  Expect = 2e-23
 Identities = 74/261 (28%), Positives = 128/261 (49%), Gaps = 34/261 (13%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIKIIDK +   +   ++  EV I++ L HP ++ L  + ET   +++V E    G++ 
Sbjct  609  VAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLH-GDML  667

Query  71   DHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIAD  125
            + +++   GR+ E   +    QI+ A+   H +NIVH DLK EN+LL   D    +K+ D
Sbjct  668  EMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCD  727

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            FGF+ +       ++  G+P Y APE+   K Y+   +D+WS+GV++YV + G  PF+  
Sbjct  728  FGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYN-RSLDMWSVGVIIYVSLSGTFPFNED  786

Query  186  TLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHM  245
              +++  ++ +  F  P        H                         E   LI ++
Sbjct  787  --EDIHDQIQNAAFMYPPNPWKEISH-------------------------EAIDLINNL  819

Query  246  LVLDPNKRLSMEQICKHKWMK  266
            L +   KR S+++   H W++
Sbjct  820  LQVKMRKRYSVDKTLSHPWLQ  840


>gi|17380162|sp|O15530|PDPK1_HUMAN  3-phosphoinositide-dependent protein kinase 1 (hPDK1)
Length=556

 Score =  107 bits (267),  Expect = 3e-23
 Identities = 71/254 (27%), Positives = 120/254 (47%), Gaps = 38/254 (14%)

Query  12   AIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            AIKI++K  + +EN +  + RE  +M  L HP  ++LY   + +  +Y    YA  GE+ 
Sbjct  109  AIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELL  168

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
             ++   G   E   R    +IV+A+ + H + I+HRDLK EN+LL+ +++I+I DFG + 
Sbjct  169  KYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAK  228

Query  131  LFTPGQ---LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
            + +P        ++ G+  Y +PEL   K       D+W+LG ++Y LV G  PF     
Sbjct  229  VLSPESKQARANSFVGTAQYVSPELLTEKS-ACKSSDLWALGCIIYQLVAGLPPFRAGNE  287

Query  188  QNLRARVLSGKFRIP--FFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHM  245
              +  +++  ++  P  FF                                +   L+  +
Sbjct  288  YLIFQKIIKLEYDFPEKFF-------------------------------PKARDLVEKL  316

Query  246  LVLDPNKRLSMEQI  259
            LVLD  KRL  E++
Sbjct  317  LVLDATKRLGCEEM  330


>gi|56404620|sp|Q8N5S9|KKCC1_HUMAN  Calcium/calmodulin-dependent protein kinase kinase 1 (Calcium/calmodulin-dependent 
protein kinase kinase alpha) (CaM-kinase 
kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase 
IV kinase)
Length=505

 Score =  106 bits (265),  Expect = 6e-23
 Identities = 68/252 (26%), Positives = 121/252 (48%), Gaps = 33/252 (13%)

Query  26   LKKIFREVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKE  83
            L+++++E+ I+K L H ++++L +V++   E  +YLV +    G + + +      +E++
Sbjct  193  LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQ  251

Query  84   ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL-LKTWC  142
            AR   + ++  + + HC+ IVHRD+K  NLLL  + ++KIADFG SN F      L +  
Sbjct  252  ARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTA  311

Query  143  GSPPYAAPELF--EGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR  200
            G+P + APE     G+ + G  +D+W+ GV LY  V G  PF    +  L  ++ +    
Sbjct  312  GTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVV  371

Query  201  IPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQIC  260
             P                     ++  +        E + LI  ML  +P  R+ +  I 
Sbjct  372  FP---------------------EEPEIS------EELKDLILKMLDKNPETRIGVPDIK  404

Query  261  KHKWMKLGDADP  272
             H W+     +P
Sbjct  405  LHPWVTKNGEEP  416


>gi|82592942|sp|O60307|MAST3_HUMAN  Microtubule-associated serine/threonine-protein kinase 3
Length=1309

 Score =  106 bits (264),  Expect = 8e-23
 Identities = 70/210 (33%), Positives = 107/210 (50%), Gaps = 18/210 (8%)

Query  10   KVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            + AIK I+K  L   N ++++F E  I+    +P ++ ++   ET R + +V EY  GG+
Sbjct  392  RFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGD  451

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
                L   G +    AR  F + V A+ + H   IVHRDLK +NLL+ +  +IK+ DFG 
Sbjct  452  CATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGL  511

Query  129  SNLFTPGQ----------------LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL  172
            S +                     + K  CG+P Y APE+   + Y G  VD W++GVVL
Sbjct  512  SKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGY-GKPVDWWAMGVVL  570

Query  173  YVLVCGALPFDGSTLQNLRARVLSGKFRIP  202
            Y  + G +PF G T + L  +V+S +   P
Sbjct  571  YEFLVGCVPFFGDTPEELFGQVVSDEIMWP  600


>gi|12643872|sp|Q9UBS0|KS6B2_HUMAN  Ribosomal protein S6 kinase 2 (S6K2) (70 kDa ribosomal protein 
S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 
S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related 
kinase) (SRK) (Serine/threonine-protein kinase 
14 beta)
Length=482

 Score =  105 bits (263),  Expect = 1e-22
 Identities = 60/198 (30%), Positives = 105/198 (53%), Gaps = 4/198 (2%)

Query  12   AIKIIDKTQL--DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K ++  + ++      E  I++ + HP I+ L    +T   +YL+ E  SGGE+
Sbjct  97   AMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGEL  156

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
            F HL   G   E  A     +I  A+   H + I++RDLK EN++L +  +IK+ DFG  
Sbjct  157  FTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLC  216

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                  G +  T+CG+  Y APE+     ++   VD WSLG ++Y ++ G+ PF     +
Sbjct  217  KESIHEGAVTHTFCGTIEYMAPEILVRSGHN-RAVDWWSLGALMYDMLTGSPPFTAENRK  275

Query  189  NLRARVLSGKFRIPFFMS  206
                +++ GK  +P +++
Sbjct  276  KTMDKIIRGKLALPPYLT  293


>gi|52000829|sp|Q8IW41|MAPK5_HUMAN  MAP kinase-activated protein kinase 5 (MAPK-activated protein 
kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein 
kinase)
Length=473

 Score =  105 bits (263),  Expect = 1e-22
 Identities = 86/320 (26%), Positives = 145/320 (45%), Gaps = 68/320 (21%)

Query  36   MKMLC--HPHIIRLYQVMETE----------RMIYLVTEYASGGEIFDHLVAHGRMAEKE  83
            + M+C  HP+I+++ +V                + +V E   GGE+F  +  H    EK+
Sbjct  65   LHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQ  124

Query  84   ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN---LNIKIADFGFSNLFTPGQLLKT  140
            A +  KQI  A+  CH  NI HRDLK ENLL   N     +K+ DFGF+ +   G L+ T
Sbjct  125  ASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKI-DQGDLM-T  182

Query  141  WCGSPPYAAPELFEG-----KEYDG------------PKVDIWSLGVVLYVLVCGALPF-  182
               +P Y AP++ E      KE  G               D+WSLGV++YV++CG  PF 
Sbjct  183  PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY  242

Query  183  ----DGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAEC  238
                  +  +++R ++++G F  P                +   AKD             
Sbjct  243  SKHHSRTIPKDMRRKIMTGSFEFP----------EEEWSQISEMAKD-------------  279

Query  239  EHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVL  298
              ++R +L + P +RL++E +  H W+   +A    D ++   Q + ++  V  + +   
Sbjct  280  --VVRKLLKVKPEERLTIEGVLDHPWLNSTEA---LDNVLPSAQLMMDKAVVAGIQQAHA  334

Query  299  LAMEDMGL-DKEQTLQSLRS  317
              + +M + D + +L+ L S
Sbjct  335  EQLANMRIQDLKVSLKPLHS  354


>gi|12230239|sp|O94806|KPCD3_HUMAN  Protein kinase D3 (Protein kinase C nu type) (nPKC-nu) (Protein 
kinase EPK2)
Length=890

 Score =  105 bits (261),  Expect = 2e-22
 Identities = 72/261 (27%), Positives = 130/261 (49%), Gaps = 34/261 (13%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK+IDK +   +   ++  EV I++ L HP I+ L  + ET   +++V E    G++ 
Sbjct  602  VAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLH-GDML  660

Query  71   DHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIAD  125
            + +++    R+ E+  +    QI+ A+   H +NIVH DLK EN+LL   +    +K+ D
Sbjct  661  EMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCD  720

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            FGF+ +       ++  G+P Y APE+   K Y+   +D+WS+GV++YV + G  PF+  
Sbjct  721  FGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYN-RSLDMWSVGVIIYVSLSGTFPFNED  779

Query  186  TLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHM  245
              +++  ++ +  F  P      +  + G                      E   LI ++
Sbjct  780  --EDINDQIQNAAFMYP---PNPWREISG----------------------EAIDLINNL  812

Query  246  LVLDPNKRLSMEQICKHKWMK  266
            L +   KR S+++   H W++
Sbjct  813  LQVKMRKRYSVDKSLSHPWLQ  833


>gi|74762208|sp|Q5MAI5|CDKL4_HUMAN  Cyclin-dependent kinase-like 4
Length=315

 Score =  104 bits (260),  Expect = 2e-22
 Identities = 66/206 (32%), Positives = 104/206 (50%), Gaps = 5/206 (2%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K   +++ D    K   RE++++K L HP+++ L +V   +R ++LV EY     + 
Sbjct  30   VAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLN  89

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            +       +A+   +    Q + A+ FCH  N +HRD+K EN+L+     IKI DFGF+ 
Sbjct  90   ELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQ  149

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG-STLQN  189
            +  PG     +  +  Y APEL  G    G  VDIW++G V   L+ G   + G S +  
Sbjct  150  ILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQ  209

Query  190  LRARVLSGKFRIP----FFMSTGYFH  211
            L   + +    IP     F S G+FH
Sbjct  210  LYLIIRTLGKLIPRHQSIFKSNGFFH  235


>gi|28558163|sp|Q96BR1|SGK3_HUMAN  Serine/threonine-protein kinase Sgk3 (Serum/glucocorticoid regulated 
kinase 3) (Serum/glucocorticoid regulated kinase-like)
Length=496

 Score =  104 bits (259),  Expect = 3e-22
 Identities = 61/174 (35%), Positives = 94/174 (54%), Gaps = 4/174 (2%)

Query  12   AIKIIDKT-QLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K   L+ +  K I  E  ++ K + HP ++ L+   +T   +Y V ++ +GGE+
Sbjct  189  AVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGEL  248

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
            F HL       E  AR    +I +A+ + H   IV+RDLK EN+LLD+  ++ + DFG  
Sbjct  249  FFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLC  308

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
                       T+CG+P Y APE+   + YD   VD W LG VLY ++ G  PF
Sbjct  309  KEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN-TVDWWCLGAVLYEMLYGLPPF  361


>gi|20141582|sp|Q04759|KPCT_HUMAN  Protein kinase C theta type (nPKC-theta)
Length=706

 Score =  104 bits (259),  Expect = 3e-22
 Identities = 60/182 (32%), Positives = 102/182 (56%), Gaps = 4/182 (2%)

Query  12   AIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            AIK + K   L +++++    E +++ +   HP +  ++   +T+  ++ V EY +GG++
Sbjct  407  AIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDL  466

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              H+ +  +     A     +I+  + F H + IV+RDLK +N+LLD + +IKIADFG  
Sbjct  467  MYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMC  526

Query  130  NLFTPGQL-LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                 G     T+CG+P Y APE+  G++Y+   VD WS GV+LY ++ G  PF G   +
Sbjct  527  KENMLGDAKTNTFCGTPDYIAPEILLGQKYN-HSVDWWSFGVLLYEMLIGQSPFHGQDEE  585

Query  189  NL  190
             L
Sbjct  586  EL  587


>gi|38502964|sp|Q86V86|PIM3_HUMAN  Serine/threonine-protein kinase Pim-3
Length=326

 Score =  103 bits (257),  Expect = 5e-22
 Identities = 73/224 (32%), Positives = 102/224 (45%), Gaps = 38/224 (16%)

Query  44   IIRLYQVMETERMIYLVTEYASGGE-IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN  102
            +IRL    E      LV E     + +FD +   G + E  ARR F Q++ AV  CH   
Sbjct  106  VIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCG  165

Query  103  IVHRDLKAENLLLDANL-NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP  161
            +VHRD+K ENLL+D     +K+ DFG S       +   + G+  Y+ PE      Y G 
Sbjct  166  VVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGR  224

Query  162  KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVL  221
               +WSLGV+LY +VCG +PF+    + LR R+L  +   P                   
Sbjct  225  SATVWSLGVLLYDMVCGDIPFEQDE-EILRGRLLFRRRVSP-------------------  264

Query  222  NAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM  265
                           EC+ LIR  L L P++R S++QI  H WM
Sbjct  265  ---------------ECQQLIRWCLSLRPSERPSLDQIAAHPWM  293


>gi|60390226|sp|Q9Y2H9|MAST1_HUMAN  Microtubule-associated serine/threonine-protein kinase 1 (Syntrophin-associated 
serine/threonine-protein kinase)
Length=1570

 Score =  103 bits (257),  Expect = 5e-22
 Identities = 69/204 (33%), Positives = 107/204 (52%), Gaps = 18/204 (8%)

Query  10   KVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            + A+K I+K  L   N +++ F E  I+    +P ++ ++   ET R + +V EY  GG+
Sbjct  399  RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGD  458

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
                L   G +  + AR  F + V A+ + H   IVHRDLK +NLL+ +  +IK+ DFG 
Sbjct  459  CATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGL  518

Query  129  S---------NLF-------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL  172
            S         NL+           L K  CG+P Y APE+   + Y G  VD W++G++L
Sbjct  519  SKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY-GKPVDWWAMGIIL  577

Query  173  YVLVCGALPFDGSTLQNLRARVLS  196
            Y  + G +PF G T + L  +V+S
Sbjct  578  YEFLVGCVPFFGDTPEELFGQVIS  601


>gi|54041234|sp|P23443|KS6B1_HUMAN  Ribosomal protein S6 kinase 1 (S6K) (S6K1) (70 kDa ribosomal 
protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) 
(p70-S6K) (p70-alpha)
Length=525

 Score =  103 bits (256),  Expect = 6e-22
 Identities = 61/198 (30%), Positives = 104/198 (52%), Gaps = 4/198 (2%)

Query  12   AIKIIDKTQL--DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K++ K  +  + ++      E  I++ + HP I+ L    +T   +YL+ EY SGGE+
Sbjct  121  AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL  180

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
            F  L   G   E  A     +I  A+   H + I++RDLK EN++L+   ++K+ DFG  
Sbjct  181  FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC  240

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
                  G +  T+CG+  Y APE+     ++   VD WSLG ++Y ++ GA PF G   +
Sbjct  241  KESIHDGTVTHTFCGTIEYMAPEILMRSGHN-RAVDWWSLGALMYDMLTGAPPFTGENRK  299

Query  189  NLRARVLSGKFRIPFFMS  206
                ++L  K  +P +++
Sbjct  300  KTIDKILKCKLNLPPYLT  317


>gi|82654922|sp|Q00532|CDKL1_HUMAN  Cyclin-dependent kinase-like 1 (Serine/threonine-protein kinase 
KKIALRE) (Protein kinase p42 KKIALRE)
Length=357

 Score =  102 bits (255),  Expect = 8e-22
 Identities = 84/269 (31%), Positives = 132/269 (49%), Gaps = 23/269 (8%)

Query  11   VAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VAIK   +++ D+  +KKI  RE++++K L HP+++ L +V   +R ++LV EY      
Sbjct  30   VAIKKFLESE-DDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYC-----  83

Query  70   FDHLVAHGR------MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI  123
             DH V H        + E   +    Q + AV FCH  N +HRD+K EN+L+  +  IK+
Sbjct  84   -DHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKL  142

Query  124  ADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
             DFGF+ L T P      +  +  Y +PEL  G    GP VD+W++G V   L+ G   +
Sbjct  143  CDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLW  202

Query  183  DG-STLQNLRARVLSGKFRIP----FFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAE  237
             G S +  L     +    IP     F +  YF   G       + +   LK   +S   
Sbjct  203  PGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFS--GVKIPDPEDMEPLELKFPNISYPA  260

Query  238  CEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
               L++  L +DP +RL+ EQ+  H + +
Sbjct  261  L-GLLKGCLHMDPTQRLTCEQLLHHPYFE  288


>gi|3041712|sp|Q13177|PAK2_HUMAN  Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2) 
(PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase)
Length=524

 Score =  102 bits (254),  Expect = 1e-21
 Identities = 61/174 (35%), Positives = 99/174 (56%), Gaps = 5/174 (2%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIK I+  +  ++ L  I  E+ +MK L +P+I+           +++V EY +GG +
Sbjct  274  EVAIKQINLQKQPKKEL--IINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSL  331

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             D +V    M E +     ++ + A+ F H   ++HRD+K++N+LL    ++K+ DFGF 
Sbjct  332  TD-VVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFC  390

Query  130  NLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
               TP Q  + T  G+P + APE+   K Y GPKVDIWSLG++   +V G  P+
Sbjct  391  AQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY  443


>gi|83305339|sp|P11309|PIM1_HUMAN  Proto-oncogene serine/threonine-protein kinase Pim-1
Length=404

 Score =  102 bits (254),  Expect = 1e-21
 Identities = 78/264 (29%), Positives = 125/264 (47%), Gaps = 44/264 (16%)

Query  11   VAIKIIDKTQLDE----ENLKKIFREVQIMKMLCHPH--IIRLYQVMETERMIYLVTEYA  64
            VAIK ++K ++ +     N  ++  EV ++K +      +IRL    E      L+ E  
Sbjct  155  VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP  214

Query  65   SG-GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL-NIK  122
                ++FD +   G + E+ AR  F Q++ AV  CH   ++HRD+K EN+L+D N   +K
Sbjct  215  EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK  274

Query  123  IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            + DFG S       +   + G+  Y+ PE      Y G    +WSLG++LY +VCG +PF
Sbjct  275  LIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF  333

Query  183  DGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLI  242
            +    + +R +V    FR                         +R+       +EC+HLI
Sbjct  334  EHDE-EIIRGQVF---FR-------------------------QRVS------SECQHLI  358

Query  243  RHMLVLDPNKRLSMEQICKHKWMK  266
            R  L L P+ R + E+I  H WM+
Sbjct  359  RWCLALRPSDRPTFEEIQNHPWMQ  382


>gi|6225859|sp|Q16513|PKN2_HUMAN  Protein kinase N2 (Protein kinase C-like 2) (Protein-kinase C-related 
kinase 2)
Length=984

 Score =  101 bits (252),  Expect = 2e-21
 Identities = 61/182 (33%), Positives = 96/182 (52%), Gaps = 6/182 (3%)

Query  27   KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARR  86
            K+IF  V  ++   HP ++ L+   +T+  +  V EYA+GG++  H+      +E  A  
Sbjct  706  KRIFETVNSVR---HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVF  761

Query  87   KFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-SNLFTPGQLLKTWCGSP  145
                +V  + + H   IV+RDLK +NLLLD    +KIADFG        G    T+CG+P
Sbjct  762  YAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTP  821

Query  146  PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFM  205
             + APE+     Y    VD W LGV++Y ++ G  PF G   + +   +++ + R P F+
Sbjct  822  EFLAPEVLTETSYT-RAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFL  880

Query  206  ST  207
            ST
Sbjct  881  ST  882


>gi|547803|sp|Q05655|KPCD_HUMAN  Protein kinase C delta type (nPKC-delta)
Length=676

 Score =  101 bits (252),  Expect = 2e-21
 Identities = 60/177 (33%), Positives = 101/177 (57%), Gaps = 6/177 (3%)

Query  12   AIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            AIK + K   L +++++    E +++ +   +P +  L    +T+  ++ V E+ +GG++
Sbjct  376  AIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDL  435

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
              H+   GR     A     +I+  + F H + I++RDLK +N+LLD + +IKIADFG  
Sbjct  436  MYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMC  495

Query  129  -SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
              N+F   +   T+CG+P Y APE+ +G +Y    VD WS GV+LY ++ G  PF G
Sbjct  496  KENIFGESR-ASTFCGTPDYIAPEILQGLKYTF-SVDWWSFGVLLYEMLIGQSPFHG  550


>gi|14423909|sp|O94768|ST17B_HUMAN  Serine/threonine-protein kinase 17B (DAP kinase-related apoptosis-inducing 
protein kinase 2)
Length=372

 Score =  101 bits (252),  Expect = 2e-21
 Identities = 78/272 (28%), Positives = 126/272 (46%), Gaps = 38/272 (13%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCH-PHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A K + K +  ++   +I  E+ ++++    P +I L++V E    I L+ EYA+GGEIF
Sbjct  60   AAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIF  119

Query  71   DHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKIAD  125
               +      ++E +  R  KQI+  VY+ H  NIVH DLK +N+LL +     +IKI D
Sbjct  120  SLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVD  179

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFD  183
            FG S        L+   G+P Y APE+     YD      D+W++G++ Y+L+    PF 
Sbjct  180  FGMSRKIGHACELREIMGTPEYLAPEIL---NYDPITTATDMWNIGIIAYMLLTHTSPFV  236

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAE-CEHLI  242
            G   Q     +                    S  NV  + +         S+++     I
Sbjct  237  GEDNQETYLNI--------------------SQVNVDYSEET------FSSVSQLATDFI  270

Query  243  RHMLVLDPNKRLSMEQICKHKWMKLGDADPNF  274
            + +LV +P KR + E    H W++  D +  F
Sbjct  271  QSLLVKNPEKRPTAEICLSHSWLQQWDFENLF  302


>gi|62287152|sp|Q6P0Q8|MAST2_HUMAN  Microtubule-associated serine/threonine-protein kinase 2
Length=1798

 Score =  100 bits (250),  Expect = 3e-21
 Identities = 68/210 (32%), Positives = 108/210 (51%), Gaps = 18/210 (8%)

Query  10   KVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            + A+K I+K  L   N +++ F E  I+    +P ++ ++   +T+R + +V EY  GG+
Sbjct  537  RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGD  596

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
                L   G +     R  F + V A+ + H   IVHRDLK +NLL+ +  +IK+ DFG 
Sbjct  597  CATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGL  656

Query  129  S---------NLF-------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL  172
            S         NL+           L K  CG+P Y APE+   + Y G  VD W++G++L
Sbjct  657  SKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY-GKPVDWWAMGIIL  715

Query  173  YVLVCGALPFDGSTLQNLRARVLSGKFRIP  202
            Y  + G +PF G T + L  +V+S +   P
Sbjct  716  YEFLVGCVPFFGDTPEELFGQVISDEIVWP  745


>gi|47605999|sp|Q13464|ROCK1_HUMAN  Rho-associated protein kinase 1 (Rho-associated, coiled-coil 
containing protein kinase 1) (p160 ROCK-1) (p160ROCK)
Length=1354

 Score =  100 bits (248),  Expect = 5e-21
 Identities = 59/198 (29%), Positives = 110/198 (55%), Gaps = 7/198 (3%)

Query  12   AIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K++ K ++ + +    F  E  IM     P +++L+   + +R +Y+V EY  GG++ 
Sbjct  103  AMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV  162

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            + L+++  + EK AR    ++V A+   H    +HRD+K +N+LLD + ++K+ADFG   
Sbjct  163  N-LMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCM  221

Query  131  LFTPGQLLK--TWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
                  +++  T  G+P Y +PE+ +   G  Y G + D WS+GV LY ++ G  PF   
Sbjct  222  KMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD  281

Query  186  TLQNLRARVLSGKFRIPF  203
            +L    +++++ K  + F
Sbjct  282  SLVGTYSKIMNHKNSLTF  299


>gi|20139243|sp|Q9P1W9|PIM2_HUMAN  Serine/threonine-protein kinase Pim-2 (Pim-2h)
Length=311

 Score =  100 bits (248),  Expect = 5e-21
 Identities = 67/228 (29%), Positives = 101/228 (44%), Gaps = 38/228 (16%)

Query  41   HPHIIRLYQVMETERMIYLVTEYA-SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH  99
            HP +IRL    ET+    LV E      ++FD++   G + E  +R  F Q+V A+  CH
Sbjct  96   HPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCH  155

Query  100  CRNIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY  158
             R +VHRD+K EN+L+D      K+ DFG S      +    + G+  Y+ PE     +Y
Sbjct  156  SRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPPEWISRHQY  214

Query  159  DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCN  218
                  +WSLG++LY +VCG +PF+          +L  +   P  +S            
Sbjct  215  HALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVS------------  256

Query  219  VVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
                              +C  LIR  L   P+ R S+E+I    WM+
Sbjct  257  -----------------PDCCALIRRCLAPKPSSRPSLEEILLDPWMQ  287


>gi|8928460|sp|O75962|TRIO_HUMAN  Triple functional domain protein (PTPRF-interacting protein)
Length=3038

 Score = 99.8 bits (247),  Expect = 7e-21
 Identities = 79/290 (27%), Positives = 129/290 (44%), Gaps = 36/290 (12%)

Query  11    VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
             VA K ++K  +  +   ++  E+ I++ L HP ++ L    ET     LV E A  G + 
Sbjct  2763  VATKFVNKKLMKRD---QVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLL  2819

Query  71    DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKIADFG  127
             D +V  G + E + R    +++ AV + H   I H DLK EN+L+D +L    IK+ADFG
Sbjct  2820  DCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFG  2879

Query  128   FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
              +        +    G+P +AAPE+  G        D WS+GV+ YVL+ G  PF   ++
Sbjct  2880  DAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTS-DTWSVGVLTYVLLSGVSPFLDDSV  2938

Query  188   QNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLV  247
             +     +     R+ F     YF        V   AK+                +  +L 
Sbjct  2939  EETCLNIC----RLDFSFPDDYFK------GVSQKAKE---------------FVCFLLQ  2973

Query  248   LDPNKRLSMEQICKHKWMKLGDADP----NFDRLIAECQQLKEERQVDPL  293
              DP KR S     + +W++ G+       +  RL +  ++ K +  V P+
Sbjct  2974  EDPAKRPSAALALQEQWLQAGNGRSTGVLDTSRLTSFIERRKHQNDVRPI  3023


>gi|74749130|sp|Q6P5Z2|PKN3_HUMAN  Protein kinase N3 (Protein kinase PKN-beta) (Protein-kinase C-related 
kinase 3)
Length=889

 Score = 99.4 bits (246),  Expect = 9e-21
 Identities = 70/225 (31%), Positives = 114/225 (50%), Gaps = 10/225 (4%)

Query  12   AIKIIDKTQ-LDEENLKKIFREVQIMKML-C--HPHIIRLYQVMETERMIYLVTEYASGG  67
            AIK + K + L  + ++ ++ E +I++ + C  HP ++ L    +T      VTE+  GG
Sbjct  586  AIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGG  645

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
            ++    +      E +AR     +V  + F H + I++RDLK +NLLLDA   +KIADFG
Sbjct  646  DLMMQ-IHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFG  704

Query  128  F-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
                    G    T+CG+P + APE+   + Y    VD W LGV+LY ++ G  PF G T
Sbjct  705  LCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYT-RAVDWWGLGVLLYEMLVGECPFPGDT  763

Query  187  LQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAG  231
             + +   +++     P F+S      +     ++    +KRL AG
Sbjct  764  EEEVFDCIVNMDAPYPGFLSVQGLEFIQ---KLLQKCPEKRLGAG  805


>gi|6174910|sp|Q16512|PKN1_HUMAN  Protein kinase N1 (Protein kinase C-like 1) (Protein-kinase C-related 
kinase 1) (Protein kinase C-like PKN) (Serine-threonine 
protein kinase N) (Protein kinase PKN-alpha)
Length=942

 Score = 98.6 bits (244),  Expect = 2e-20
 Identities = 67/206 (32%), Positives = 104/206 (50%), Gaps = 4/206 (1%)

Query  3    PTFQFAAKVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVT  61
            P+ +  A  A+K  D    DE E+L    R +  +    HP ++ L+   +T   +  V 
Sbjct  636  PSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVM  695

Query  62   EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
            EY++GG++  H+ +    +E  A      +V  + F H   IV+RDLK +NLLLD    +
Sbjct  696  EYSAGGDLMLHIHSDV-FSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYV  754

Query  122  KIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL  180
            KIADFG        G    T+CG+P + APE+     Y    VD W LGV+LY ++ G  
Sbjct  755  KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYT-RAVDWWGLGVLLYEMLVGES  813

Query  181  PFDGSTLQNLRARVLSGKFRIPFFMS  206
            PF G   + +   +++ + R P F+S
Sbjct  814  PFPGDDEEEVFDSIVNDEVRYPRFLS  839


>gi|20178297|sp|P51956|NEK3_HUMAN  Serine/threonine-protein kinase Nek3 (NimA-related protein kinase 
3) (HSPK 36)
Length=506

 Score = 98.2 bits (243),  Expect = 2e-20
 Identities = 56/176 (31%), Positives = 93/176 (52%), Gaps = 4/176 (2%)

Query  25   NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH-GRM-AEK  82
            N +   +E  ++  + HP+I+   +  E E  +Y+V EY  GG++   +    G++  E 
Sbjct  43   NTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPED  102

Query  83   EARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFT-PGQLLKTW  141
                 F Q+   V   H + ++HRD+K++N+ L  N  +K+ DFG + L + P     T+
Sbjct  103  MILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTY  162

Query  142  CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSG  197
             G+P Y  PE++E   Y+  K DIWSLG +LY L     PF  ++ +NL  +V  G
Sbjct  163  VGTPYYVPPEIWENLPYNN-KSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG  217


>gi|2499643|sp|Q13153|PAK1_HUMAN  Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1) 
(PAK-1) (P65-PAK) (Alpha-PAK)
Length=545

 Score = 97.8 bits (242),  Expect = 3e-20
 Identities = 58/174 (33%), Positives = 99/174 (56%), Gaps = 5/174 (2%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIK ++  Q  ++ L  I  E+ +M+   +P+I+           +++V EY +GG +
Sbjct  295  EVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL  352

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             D +V    M E +     ++ + A+ F H   ++HRD+K++N+LL  + ++K+ DFGF 
Sbjct  353  TD-VVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC  411

Query  130  NLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
               TP Q  + T  G+P + APE+   K Y GPKVDIWSLG++   ++ G  P+
Sbjct  412  AQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMIEGEPPY  464


>gi|47117818|sp|O75914|PAK3_HUMAN  Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3) 
(PAK-3) (Beta-PAK) (Oligophrenin-3)
Length=559

 Score = 97.8 bits (242),  Expect = 3e-20
 Identities = 59/174 (33%), Positives = 99/174 (56%), Gaps = 5/174 (2%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIK ++  Q  ++ L  I  E+ +M+   +P+I+           +++V EY +GG +
Sbjct  308  EVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSL  365

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             D +V    M E +     ++ + A+ F H   ++HRD+K++N+LL  + ++K+ DFGF 
Sbjct  366  TD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFC  424

Query  130  NLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
               TP Q  + T  G+P + APE+   K Y GPKVDIWSLG++   +V G  P+
Sbjct  425  AQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY  477


>gi|30316125|sp|Q9HBH9|MKNK2_HUMAN  MAP kinase-interacting serine/threonine-protein kinase 2 (MAP 
kinase signal-integrating kinase 2) (Mnk2)
Length=418

 Score = 97.8 bits (242),  Expect = 3e-20
 Identities = 89/289 (30%), Positives = 128/289 (44%), Gaps = 64/289 (22%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KII+K      +  ++FREV+++ +   H +++ L +  E E   YLV E   GG I 
Sbjct  64   AVKIIEKQPGHIRS--RVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSIL  121

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFG  127
             H+       E EA    + + +A+ F H + I HRDLK EN+L +       +KI DF 
Sbjct  122  SHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFD  181

Query  128  F----------SNLFTPGQLLKTWCGSPPYAAPELF-----EGKEYDGPKVDIWSLGVVL  172
                       S + TP   L T CGS  Y APE+      E   YD  + D+WSLGV+L
Sbjct  182  LGSGIKLNGDCSPISTPE--LLTPCGSAEYMAPEVVEAFSEEASIYD-KRCDLWSLGVIL  238

Query  173  YVLVCGALPFDG--------------STLQN-LRARVLSGKFRIPFFMSTGYFHLLGSHC  217
            Y+L+ G  PF G                 QN L   +  GK+  P      + H      
Sbjct  239  YILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFP---DKDWAH------  289

Query  218  NVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
             +   AKD               LI  +LV D  +RLS  Q+ +H W++
Sbjct  290  -ISCAAKD---------------LISKLLVRDAKQRLSAAQVLQHPWVQ  322


>gi|74762639|sp|Q92772|CDKL2_HUMAN  Cyclin-dependent kinase-like 2 (Serine/threonine-protein kinase 
KKIAMRE) (Protein kinase p56 KKIAMRE)
Length=493

 Score = 97.4 bits (241),  Expect = 4e-20
 Identities = 52/167 (31%), Positives = 94/167 (56%), Gaps = 2/167 (1%)

Query  22   DEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMA  80
            D++ +KKI  RE++++K L H +++ L +V + ++  YLV E+     + D  +    + 
Sbjct  40   DDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLD  99

Query  81   EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-NLFTPGQLLK  139
             +  ++   QI+  + FCH  NI+HRD+K EN+L+  +  +K+ DFGF+  L  PG++  
Sbjct  100  YQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYT  159

Query  140  TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
             +  +  Y APEL  G    G  VD+W++G ++  +  G   F G +
Sbjct  160  DYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDS  206


>gi|13626607|sp|Q9Y6E0|STK24_HUMAN  Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3) 
(Mammalian STE20-like protein kinase 3)
Length=443

 Score = 97.1 bits (240),  Expect = 5e-20
 Identities = 55/172 (31%), Positives = 95/172 (55%), Gaps = 4/172 (2%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIKIID  + ++E ++ I +E+ ++     P++ + Y     +  ++++ EY  GG   
Sbjct  62   VAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSAL  120

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            D L+  G + E +     ++I+  + + H    +HRD+KA N+LL  +  +K+ADFG + 
Sbjct  121  D-LLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAG  179

Query  131  LFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP  181
              T  Q+ + T+ G+P + APE+ +   YD  K DIWSLG+    L  G  P
Sbjct  180  QLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS-KADIWSLGITAIELARGEPP  230


>gi|73621232|sp|Q9P289|MST4_HUMAN  Serine/threonine-protein kinase MST4 (STE20-like kinase MST4) 
(MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein 
kinase MASK) (Mst3 and SOK1-related kinase)
Length=416

 Score = 96.7 bits (239),  Expect = 6e-20
 Identities = 78/286 (27%), Positives = 129/286 (45%), Gaps = 17/286 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIKIID  + ++E ++ I +E+ ++      ++ + Y        ++++ EY  GG   
Sbjct  50   VAIKIIDLEEAEDE-IEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSAL  108

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            D L A G   E +     K+I+  + + H    +HRD+KA N+LL    ++K+ADFG + 
Sbjct  109  DLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAG  167

Query  131  LFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
              T  Q+ + T+ G+P + APE+ +   YD  K DIWSLG+    L  G  P   S +  
Sbjct  168  QLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS-KADIWSLGITAIELAKGEPP--NSDMHP  224

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            +R   L  K   P         L+G          D  L          + L++H  ++ 
Sbjct  225  MRVLFLIPKNNPP--------TLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVK  276

Query  250  PNKRLS--MEQICKHK-WMKLGDADPNFDRLIAECQQLKEERQVDP  292
             +K+ S   E I + K W   G +D   D   ++ +    E    P
Sbjct  277  NSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHP  322


>gi|1705489|sp|P51813|BMX_HUMAN  Cytoplasmic tyrosine-protein kinase BMX (Bone marrow tyrosine 
kinase gene in chromosome X protein) (Epithelial and endothelial 
tyrosine kinase) (ETK) (NTK38)
Length=675

 Score = 95.9 bits (237),  Expect = 1e-19
 Identities = 56/177 (31%), Positives = 95/177 (53%), Gaps = 8/177 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K+I +  + E+   + F+E Q M  L HP +++ Y V   E  IY+VTEY S G + 
Sbjct  442  VAVKMIKEGSMSED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLL  498

Query  71   DHLVAHGRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            ++L +HG+  E  +       +   + F      +HRDL A N L+D +L +K++DFG +
Sbjct  499  NYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMT  558

Query  130  NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFD  183
                  Q + +     P  ++APE+F   +Y   K D+W+ G++++ V   G  P+D
Sbjct  559  RYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSS-KSDVWAFGILMWEVFSLGKQPYD  614


>gi|47605963|sp|O75116|ROCK2_HUMAN  Rho-associated protein kinase 2 (Rho-associated, coiled-coil 
containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2)
Length=1388

 Score = 95.5 bits (236),  Expect = 1e-19
 Identities = 57/198 (28%), Positives = 109/198 (55%), Gaps = 7/198 (3%)

Query  12   AIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K++ K ++ + +    F  E  IM     P +++L+   + +R +Y+V EY  GG++ 
Sbjct  119  AMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLV  178

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            + L+++  + EK A+    ++V A+   H   ++HRD+K +N+LLD + ++K+ADFG   
Sbjct  179  N-LMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCM  237

Query  131  LFTPGQLL--KTWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
                  ++   T  G+P Y +PE+ +   G  + G + D WS+GV LY ++ G  PF   
Sbjct  238  KMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD  297

Query  186  TLQNLRARVLSGKFRIPF  203
            +L    ++++  K  + F
Sbjct  298  SLVGTYSKIMDHKNSLCF  315


>gi|12585288|sp|O96013|PAK4_HUMAN  Serine/threonine-protein kinase PAK 4 (p21-activated kinase 4) 
(PAK-4)
Length=591

 Score = 95.5 bits (236),  Expect = 1e-19
 Identities = 55/173 (31%), Positives = 98/173 (56%), Gaps = 5/173 (2%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K +D  +     L  +F EV IM+   H +++ +Y        +++V E+  GG + 
Sbjct  347  VAVKKMDLRKQQRREL--LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALT  404

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S  129
            D +V H RM E++       ++ A+   H + ++HRD+K++++LL  +  +K++DFGF +
Sbjct  405  D-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA  463

Query  130  NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
             +       K+  G+P + APEL     Y GP+VDIWSLG+++  +V G  P+
Sbjct  464  QVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPY  515


>gi|2499640|sp|Q99759|M3K3_HUMAN  Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase 
kinase 3) (MEK kinase 3) (MEKK 3)
Length=626

 Score = 95.1 bits (235),  Expect = 2e-19
 Identities = 51/157 (32%), Positives = 87/157 (55%), Gaps = 7/157 (4%)

Query  32   EVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK  89
            E+Q++K L H  I++ Y  +    E+ + +  EY  GG + D L A+G + E   R+  +
Sbjct  412  EIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR  471

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS----NLFTPGQLLKTWCGSP  145
            QI+  + + H   IVHRD+K  N+L D+  N+K+ DFG S     +   G  +++  G+P
Sbjct  472  QILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTP  531

Query  146  PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
             + +PE+  G+ Y G K D+WSLG  +  ++    P+
Sbjct  532  YWMSPEVISGEGY-GRKADVWSLGCTVVEMLTEKPPW  567


>gi|6685620|sp|Q9Y2U5|M3K2_HUMAN  Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase 
kinase 2) (MEK kinase 2) (MEKK 2)
Length=618

 Score = 94.7 bits (234),  Expect = 2e-19
 Identities = 51/157 (32%), Positives = 86/157 (54%), Gaps = 7/157 (4%)

Query  32   EVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK  89
            E+Q++K   H  I++ Y  +    E+ + +  EY  GG I D L A+G + E   R+  +
Sbjct  405  EIQLLKNFLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTR  464

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS----NLFTPGQLLKTWCGSP  145
            QI+  V++ H   I+HRD+K  N+L D+  N+K+ DFG S     +   G  +K+  G+P
Sbjct  465  QILEGVHYLHSNMILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTP  524

Query  146  PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
             + +PE+  G+ Y G K DIWS+   +  ++    P+
Sbjct  525  YWMSPEVISGQGY-GRKADIWSVACTVVEMLTEKPPW  560


>gi|12643529|sp|O00506|STK25_HUMAN  Serine/threonine-protein kinase 25 (Sterile 20/oxidant stress-response 
kinase 1) (Ste20/oxidant stress response kinase 1) 
(SOK-1) (Ste20-like kinase)
Length=426

 Score = 94.4 bits (233),  Expect = 3e-19
 Identities = 61/189 (32%), Positives = 99/189 (52%), Gaps = 6/189 (3%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIKIID  + ++E ++ I +E+ ++     P+I R +        ++++ EY  GG   
Sbjct  46   VAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSAL  104

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            D L+  G + E       ++I+  + + H    +HRD+KA N+LL    ++K+ADFG + 
Sbjct  105  D-LLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAG  163

Query  131  LFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
              T  Q+ + T+ G+P + APE+ +   YD  K DIWSLG+    L  G  P   S L  
Sbjct  164  QLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF-KADIWSLGITAIELAKGEPP--NSDLHP  220

Query  190  LRARVLSGK  198
            +R   L  K
Sbjct  221  MRVLFLIPK  229


>gi|73621340|sp|O95747|OXSR1_HUMAN  Serine/threonine-protein kinase OSR1 (Oxidative stress-responsive 
1 protein)
Length=527

 Score = 94.4 bits (233),  Expect = 3e-19
 Identities = 58/187 (31%), Positives = 97/187 (51%), Gaps = 15/187 (8%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KVAIK I+  +  + ++ ++ +E+Q M    HP+I+  Y     +  ++LV +  SGG +
Sbjct  42   KVAIKRINLEKC-QTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSV  100

Query  70   FD---HLVAHGR-----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
             D   H+VA G      + E       ++++  + + H    +HRD+KA N+LL  + ++
Sbjct  101  LDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV  160

Query  122  KIADFGFSNLFTPG------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
            +IADFG S     G      ++ KT+ G+P + APE+ E       K DIWS G+    L
Sbjct  161  QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIEL  220

Query  176  VCGALPF  182
              GA P+
Sbjct  221  ATGAAPY  227


>gi|6175070|sp|O76039|CDKL5_HUMAN  Cyclin-dependent kinase-like 5 (Serine/threonine-protein kinase 
9)
Length=1030

 Score = 93.6 bits (231),  Expect = 5e-19
 Identities = 79/264 (29%), Positives = 130/264 (49%), Gaps = 20/264 (7%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG--E  68
            VAIK    ++ +EE  +   RE+++++ L   +I+ L +       +YLV EY      E
Sbjct  39   VAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLE  98

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            + + +  +G   EK  +    Q++ A+++CH  +IVHRD+K ENLL+  N  +K+ DFGF
Sbjct  99   LLEEM-PNGVPPEK-VKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGF  156

Query  129  SNLFTPGQLLK--TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS-  185
            +   + G       +  +  Y +PEL  G  Y G  VD+WS+G +L  L  G   F G  
Sbjct  157  ARNLSEGNNANYTEYVATRWYRSPELLLGAPY-GKSVDMWSVGCILGELSDGQPLFPGES  215

Query  186  ------TLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKD-KRLKAGCLSIAEC  238
                  T+Q +   + S + ++  F S   FH  G     V + +  +R   G L+    
Sbjct  216  EIDQLFTIQKVLGPLPSEQMKL--FYSNPRFH--GLRFPAVNHPQSLERRYLGILNSVLL  271

Query  239  EHLIRHMLVLDPNKRLSMEQICKH  262
            + L++++L LDP  R   EQ   H
Sbjct  272  D-LMKNLLKLDPADRYLTEQCLNH  294


>gi|12585290|sp|Q9P286|PAK7_HUMAN  Serine/threonine-protein kinase PAK 7 (p21-activated kinase 7) 
(PAK-7) (PAK-5)
Length=719

 Score = 93.6 bits (231),  Expect = 5e-19
 Identities = 57/184 (30%), Positives = 105/184 (57%), Gaps = 6/184 (3%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VA+K +D  +     L  +F EV IM+   H +++ +Y        +++V E+  GG +
Sbjct  474  QVAVKKMDLRKQQRREL--LFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGAL  531

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
             D +V H RM E++       ++ A+ + H + ++HRD+K++++LL ++  IK++DFGF 
Sbjct  532  TD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFC  590

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP-FDGSTL  187
            + +       K+  G+P + APE+     Y G +VDIWSLG+++  ++ G  P F+   L
Sbjct  591  AQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWSLGIMVIEMIDGEPPYFNEPPL  649

Query  188  QNLR  191
            Q +R
Sbjct  650  QAMR  653


>gi|74715639|sp|Q8NG66|NEK11_HUMAN  Serine/threonine-protein kinase Nek11 (NimA-related protein kinase 
11) (Never in mitosis A-related kinase 11)
Length=645

 Score = 92.8 bits (229),  Expect = 9e-19
 Identities = 59/190 (31%), Positives = 96/190 (50%), Gaps = 7/190 (3%)

Query  13   IKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDH  72
            +K I   +L+     +   E Q++  L HP I++ +     +    ++TEY  G ++ D 
Sbjct  60   LKEISVGELNPNETVQANLEAQLLSKLDHPAIVKFHASFVEQDNFCIITEYCEGRDLDDK  119

Query  73   LVAHGRMA----EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            +  + +      E +    F Q++  V + H R I+HRDLK++N+ L  NL +KI DFG 
Sbjct  120  IQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKNNL-LKIGDFGV  178

Query  129  SNLFTPG-QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
            S L      L  T  G+P Y +PE  + + YD  K DIWSL  +LY + C    F GS  
Sbjct  179  SRLLMGSCDLATTLTGTPHYMSPEALKHQGYD-TKSDIWSLACILYEMCCMNHAFAGSNF  237

Query  188  QNLRARVLSG  197
             ++  +++ G
Sbjct  238  LSIVLKIVEG  247


>gi|34098605|sp|Q8TD19|NEK9_HUMAN  Serine/threonine-protein kinase Nek9 (NimA-related protein kinase 
9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8)
Length=979

 Score = 92.4 bits (228),  Expect = 1e-18
 Identities = 59/190 (31%), Positives = 102/190 (53%), Gaps = 4/190 (2%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            V  K +D T+L E+  +    E+ I+ +L H +II  Y        + +  EY +GG ++
Sbjct  78   VVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLY  137

Query  71   DHLVAH-GRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            D ++    ++ E+E    +  QIV+AV   H   I+HRD+K  N+ L     IK+ D+G 
Sbjct  138  DKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGL  197

Query  129  S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
            +  L +   + +T  G+P Y +PEL +G +Y+  K DIW++G V++ L+     FD +  
Sbjct  198  AKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF-KSDIWAVGCVIFELLTLKRTFDATNP  256

Query  188  QNLRARVLSG  197
             NL  +++ G
Sbjct  257  LNLCVKIVQG  266


>gi|74762479|sp|Q8IVW4|CDKL3_HUMAN  Cyclin-dependent kinase-like 3 (Serine/threonine protein kinase 
NKIAMRE)
Length=592

 Score = 92.4 bits (228),  Expect = 1e-18
 Identities = 77/264 (29%), Positives = 128/264 (48%), Gaps = 18/264 (6%)

Query  11   VAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VAIKI    +  E+++ KI  RE++ +K   H +++ L +V   ++ I+LV E+     +
Sbjct  30   VAIKIF--YERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDH-TV  86

Query  70   FDHL--VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
             D L    HG +  K  R+   QI+ A+ + H  NI+HRD+K EN+L+  +   K+ DFG
Sbjct  87   LDELQHYCHG-LESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFG  145

Query  128  FS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
            F+  L  PG +   +  +  Y APEL       G  VDIW+LG ++  +  G      S+
Sbjct  146  FARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSS  205

Query  187  LQNLRARV------LSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEH  240
              +L  ++      LS   +  F  S  +  ++        NA+ K  K   L +A+  H
Sbjct  206  DLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGL-LADIVH  264

Query  241  LIRHMLVLDPNKRLSMEQICKHKW  264
                 L +DP  R+S   +  H++
Sbjct  265  A---CLQIDPADRISSSDLLHHEY  285


>gi|231726|sp|Q00526|CDK3_HUMAN  Cell division protein kinase 3
Length=305

 Score = 92.0 bits (227),  Expect = 1e-18
 Identities = 64/191 (33%), Positives = 97/191 (50%), Gaps = 28/191 (14%)

Query  11   VAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS----  65
            VA+K I +  L+ E +     RE+ ++K L HP+I+RL  V+  ER +YLV E+ S    
Sbjct  30   VALKKI-RLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLK  88

Query  66   -------GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN  118
                   G E+  HL+          +    Q++  V FCH   ++HRDLK +NLL++  
Sbjct  89   KYMDSTPGSELPLHLI----------KSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINEL  138

Query  119  LNIKIADFGFSNLFTPGQLLKTWCGSPP---YAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
              IK+ADFG +  F  G  L+T+        Y APE+  G ++    VDIWS+G +   +
Sbjct  139  GAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEM  196

Query  176  VCGALPFDGST  186
            V     F G +
Sbjct  197  VTRKALFPGDS  207


>gi|74746874|sp|Q5VT25|MRCKA_HUMAN  Serine/threonine-protein kinase MRCK alpha (CDC42-binding protein 
kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding 
kinase alpha) (Myotonic dystrophy protein kinase-like 
alpha) (MRCK alpha) (DMPK-like alpha)
Length=1732

 Score = 92.0 bits (227),  Expect = 1e-18
 Identities = 62/200 (31%), Positives = 106/200 (53%), Gaps = 8/200 (4%)

Query  12   AIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI++K ++ +      FRE + ++    +  I  L+   + +  +YLV +Y  GG++ 
Sbjct  104  AMKILNKWEMLKRAETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLL  163

Query  71   DHLVA-HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L     R+ E  AR    ++V A+   H  + VHRD+K +N+L+D N +I++ADFG  
Sbjct  164  TLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSC  223

Query  130  -NLFTPGQLLKTWC-GSPPYAAPELF----EGKEYDGPKVDIWSLGVVLYVLVCGALPFD  183
              L   G +  +   G+P Y +PE+     +GK   GP+ D WSLGV +Y ++ G  PF 
Sbjct  224  LKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFY  283

Query  184  GSTLQNLRARVLSGKFRIPF  203
              +L     ++++ K R  F
Sbjct  284  AESLVETYGKIMNHKERFQF  303


 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 33/135 (24%), Positives = 65/135 (48%), Gaps = 20/135 (14%)

Query  1182  EGSALGKQLN--LKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQ-------  1232
             E +A+ ++L+   + +  ++    T  + RE L     +  + L+ +++ L+        
Sbjct  515   EANAVRQELDDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKL  574

Query  1233  ------EMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQ--EGARQKLHE  1284
                   E+++ L E+  + Q      + K +EE++L  QKVE LR EL+  E A+++L  
Sbjct  575   AMQEFMEINERLTELHTQKQKLARHVRDK-EEEVDLVMQKVESLRQELRRTERAKKELEV  633

Query  1285  LQEKLSPLGEEMRDR  1299
               E L+   E  +DR
Sbjct  634   HTEALA--AEASKDR  646


>gi|3915762|sp|P53667|LIMK1_HUMAN  LIM domain kinase 1 (LIMK-1)
Length=647

 Score = 91.3 bits (225),  Expect = 3e-18
 Identities = 53/173 (30%), Positives = 91/173 (52%), Gaps = 17/173 (9%)

Query  20   QLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRM  79
            + DEE  +   +EV++M+ L HP++++   V+  ++ +  +TEY  GG +   + +    
Sbjct  372  RFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQ  431

Query  80   AEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF----TP  134
                 R  F K I + + + H  NI+HRDL + N L+  N N+ +ADFG + L     T 
Sbjct  432  YPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQ  491

Query  135  GQLLK-----------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
             + L+           T  G+P + APE+  G+ YD  KVD++S G+VL  ++
Sbjct  492  PEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYD-EKVDVFSFGIVLCEII  543


>gi|74762299|sp|Q6DT37|MRCKG_HUMAN  Serine/threonine-protein kinase MRCK gamma (CDC42-binding protein 
kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding 
kinase gamma) (Myotonic dystrophy protein kinase-like 
alpha) (MRCK gamma) (DMPK-like gamma)
Length=1551

 Score = 90.1 bits (222),  Expect = 6e-18
 Identities = 61/200 (30%), Positives = 105/200 (52%), Gaps = 8/200 (4%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPH-IIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K++ K ++ +      FRE + + +      +  L+   + E  +YLV +Y +GG++ 
Sbjct  98   AMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLL  157

Query  71   DHLVA-HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L     R+  + A+    ++V A++  H    VHRD+K +N+LLD N +I++ADFG  
Sbjct  158  TLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSC  217

Query  130  -NLFTPGQL-LKTWCGSPPYAAPELF----EGKEYDGPKVDIWSLGVVLYVLVCGALPFD  183
              L T G +      G+P Y +PE+     EGK + GP+ D WSLGV  Y L+ G  PF 
Sbjct  218  LRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFY  277

Query  184  GSTLQNLRARVLSGKFRIPF  203
              +L     ++++ +  + F
Sbjct  278  AESLVETYGKIMNHEDHLQF  297


>gi|23396789|sp|Q9NQU5|PAK6_HUMAN  Serine/threonine-protein kinase PAK 6 (p21-activated kinase 6) 
(PAK-6) (PAK-5)
Length=681

 Score = 89.4 bits (220),  Expect = 1e-17
 Identities = 52/184 (28%), Positives = 106/184 (57%), Gaps = 6/184 (3%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VA+K++D  +     L  +F EV IM+   H +++ +Y+       ++++ E+  GG +
Sbjct  432  QVAVKMMDLRKQQRREL--LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGAL  489

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
             D +V+  R+ E++     + ++ A+ + H + ++HRD+K++++LL  +  +K++DFGF 
Sbjct  490  TD-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFC  548

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP-FDGSTL  187
            + +       K+  G+P + APE+     Y   +VDIWSLG+++  +V G  P F  S +
Sbjct  549  AQISKDVPKRKSLVGTPYWMAPEVISRSLY-ATEVDIWSLGIMVIEMVDGEPPYFSDSPV  607

Query  188  QNLR  191
            Q ++
Sbjct  608  QAMK  611


>gi|2833269|sp|Q15835|RK_HUMAN  Rhodopsin kinase precursor (RK) (G protein-coupled receptor kinase 
1)
Length=563

 Score = 89.0 bits (219),  Expect = 1e-17
 Identities = 81/259 (31%), Positives = 123/259 (47%), Gaps = 22/259 (8%)

Query  10   KVAIKIIDKTQLDEENLKK------IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            K   K+    +L+++ LKK         E +I+  +    I+ L    ET+  + LV   
Sbjct  210  KATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTI  269

Query  64   ASGGEIFDHL--VAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANL  119
             +GG+I  H+  V        E R  F   QI+  +   H R IV+RDLK EN+LLD + 
Sbjct  270  MNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDG  329

Query  120  NIKIADFGFSNLFTPGQ-LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
            N++I+D G +     GQ   K + G+P + APEL +G+EYD   VD ++LGV LY ++  
Sbjct  330  NVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDF-SVDYFALGVTLYEMIAA  388

Query  179  ALPF--DGSTLQN--LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLS  234
              PF   G  ++N  L+ R++S   + P      +       C  +L  KD   + G   
Sbjct  389  RGPFRARGEKVENKELKHRIISEPVKYP----DKFSQASKDFCEALLE-KDPEKRLG-FR  442

Query  235  IAECEHLIRHMLVLDPNKR  253
               C+ L  H L  D N R
Sbjct  443  DETCDKLRAHPLFKDLNWR  461


>gi|1708824|sp|P53671|LIMK2_HUMAN  LIM domain kinase 2 (LIMK-2)
Length=638

 Score = 89.0 bits (219),  Expect = 1e-17
 Identities = 55/176 (31%), Positives = 89/176 (50%), Gaps = 22/176 (12%)

Query  22   DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAE  81
            DEE  K    EV++M+ L HP++++   V+  ++ + L+TEY  GG + D L +      
Sbjct  366  DEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPW  425

Query  82   KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF---------  132
            ++  R  K I + + + H   I+HRDL + N L+  +  + +ADFG S L          
Sbjct  426  QQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPM  485

Query  133  ----TPGQLLK--------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
                T  + L+        T  G+P + APE+  GK YD   VDI+S G+VL  ++
Sbjct  486  EKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYD-ETVDIFSFGIVLCEII  540


>gi|46396051|sp|Q9Y2A5|DUET_HUMAN  Serine/threonine-protein kinase Duet (Serine/threonine kinase 
with Dbl- and pleckstrin homology domain)
Length=1289

 Score = 89.0 bits (219),  Expect = 1e-17
 Identities = 58/220 (26%), Positives = 99/220 (45%), Gaps = 7/220 (3%)

Query  11    VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
             VA+K + K    +E       E  +++ L HP  I L+   E+     L+ E    G + 
Sbjct  1013  VAVKFVSKKMKKKEQAA---HEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLL  1069

Query  71    DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKIADFG  127
             D+L+ H  + E++     + I+ A+ + H   + H D+K ENLL+D  +    +K+ D  
Sbjct  1070  DYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLE  1129

Query  128   FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
              +   +    +    G+P +AAPE+ +G        DIWS+GV+ YV++ G  PF   + 
Sbjct  1130  DAVQISGHFHIHHLLGNPEFAAPEVIQGIPV-SLGTDIWSIGVLTYVMLSGVSPFLDESK  1188

Query  188   QNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKR  227
             +     V    F  P     G  +      NV+L    +R
Sbjct  1189  EETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRR  1228


>gi|125480|sp|P07948|LYN_HUMAN  Tyrosine-protein kinase Lyn
Length=512

 Score = 88.6 bits (218),  Expect = 2e-17
 Identities = 60/200 (30%), Positives = 102/200 (51%), Gaps = 10/200 (5%)

Query  8    AAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
            + KVA+K +    +   +++    E  +MK L H  ++RLY V+  E  IY++TEY + G
Sbjct  269  STKVAVKTLKPGTM---SVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKG  325

Query  68   EIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD  125
             + D L +   G++   +      QI   + +   +N +HRDL+A N+L+  +L  KIAD
Sbjct  326  SLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIAD  385

Query  126  FGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPF  182
            FG + +    +         P  + APE      +   K D+WS G++LY +V  G +P+
Sbjct  386  FGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT-IKSDVWSFGILLYEIVTYGKIPY  444

Query  183  DGSTLQNLRARVLSGKFRIP  202
             G T  ++    LS  +R+P
Sbjct  445  PGRTNADVMT-ALSQGYRMP  463


>gi|115922|sp|P06493|CDC2_HUMAN  Cell division control protein 2 homolog (p34 protein kinase) 
(Cyclin-dependent kinase 1) (CDK1)
Length=297

 Score = 88.6 bits (218),  Expect = 2e-17
 Identities = 72/258 (27%), Positives = 114/258 (44%), Gaps = 5/258 (1%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG--E  68
            VA+K I     +E       RE+ ++K L HP+I+ L  V+  +  +YL+ E+ S    +
Sbjct  30   VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKK  89

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
              D +     M     +    QI+  + FCH R ++HRDLK +NLL+D    IK+ADFG 
Sbjct  90   YLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGL  149

Query  129  SNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
            +  F  P ++      +  Y +PE+  G       VDIWS+G +   L      F G + 
Sbjct  150  ARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE  209

Query  188  QNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECE-HLIRHML  246
             +   R+       P          L  + N     K   L +   ++ E    L+  ML
Sbjct  210  IDQLFRIFRA-LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKML  268

Query  247  VLDPNKRLSMEQICKHKW  264
            + DP KR+S +    H +
Sbjct  269  IYDPAKRISGKMALNHPY  286


>gi|12643880|sp|Q9UEW8|STK39_HUMAN  STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related 
kinase) (Serine/threonine-protein kinase 39) (DCHT)
Length=547

 Score = 88.6 bits (218),  Expect = 2e-17
 Identities = 55/187 (29%), Positives = 96/187 (51%), Gaps = 15/187 (8%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIK I+  +  + ++ ++ +E+Q M    HP+++  Y     +  ++LV +  SGG +
Sbjct  90   RVAIKRINLEKC-QTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSM  148

Query  70   FD---HLVAHGR-----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
             D   ++V  G      + E       K+++  + + H    +HRDLKA N+LL  + ++
Sbjct  149  LDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSV  208

Query  122  KIADFGFSNLFTPG------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
            +IADFG S     G      ++ KT+ G+P + APE+ E       K D+WS G+    L
Sbjct  209  QIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIEL  268

Query  176  VCGALPF  182
              GA P+
Sbjct  269  ATGAAPY  275


>gi|56749668|sp|Q9Y2H1|ST38L_HUMAN  Serine/threonine-protein kinase 38-like (NDR2 protein kinase) 
(Nuclear Dbf2-related kinase 2)
Length=464

 Score = 88.2 bits (217),  Expect = 2e-17
 Identities = 62/229 (27%), Positives = 108/229 (47%), Gaps = 38/229 (16%)

Query  12   AIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+ K+  L++E +  I  E  I+       +++++   + +R +YL+ E+  GG++ 
Sbjct  117  AMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMM  176

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG---  127
              L+    + E+E +    + V A+   H    +HRD+K +NLLLDA  ++K++DFG   
Sbjct  177  TLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCT  236

Query  128  -----------------------FSNLFTPG----------QLLKTWCGSPPYAAPELFE  154
                                   F N+ +            QL  +  G+P Y APE+F 
Sbjct  237  GLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFM  296

Query  155  GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF  203
               Y+    D WSLGV++Y ++ G  PF   T Q    +V++ K  + F
Sbjct  297  QTGYN-KLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVF  344


>gi|4033704|sp|Q00535|CDK5_HUMAN  Cell division protein kinase 5 (Tau protein kinase II catalytic 
subunit) (TPKII catalytic subunit) (Serine/threonine-protein 
kinase PSSALRE)
Length=292

 Score = 87.8 bits (216),  Expect = 3e-17
 Identities = 69/271 (25%), Positives = 126/271 (46%), Gaps = 32/271 (11%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG--E  68
            VA+K +     DE       RE+ ++K L H +I+RL+ V+ +++ + LV E+      +
Sbjct  30   VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKK  89

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
             FD    +G +  +  +    Q++  + FCH RN++HRDLK +NLL++ N  +K+ADFG 
Sbjct  90   YFDS--CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGL  147

Query  129  SNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP-FDGST  186
            +  F  P +       +  Y  P++  G +     +D+WS G +   L     P F G+ 
Sbjct  148  ARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGND  207

Query  187  LQNLRARVL-----------SGKFRIPFFMSTGYFHLLGSHCNVV--LNAKDKRLKAGCL  233
            + +   R+                ++P +     +    S  NVV  LNA  +       
Sbjct  208  VDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGR-------  260

Query  234  SIAECEHLIRHMLVLDPNKRLSMEQICKHKW  264
                   L++++L  +P +R+S E+  +H +
Sbjct  261  ------DLLQNLLKCNPVQRISAEEALQHPY  285


>gi|1709347|sp|P51957|NEK4_HUMAN  Serine/threonine-protein kinase Nek4 (NimA-related protein kinase 
4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein 
kinase NRK2)
Length=841

 Score = 87.4 bits (215),  Expect = 4e-17
 Identities = 52/172 (30%), Positives = 90/172 (52%), Gaps = 5/172 (2%)

Query  31   REVQIMKMLCHPHIIRLYQVMET-ERMIYLVTEYASGGEIFDHLVAHGR--MAEKEARRK  87
            +E Q++  L HP+I+   +  E  + ++Y+V  +  GG+++  L       + E +    
Sbjct  52   QEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEW  111

Query  88   FKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN-LFTPGQLLKTWCGSPP  146
            F QI  A+ + H ++I+HRDLK +N+ L     IK+ D G +  L     +  T  G+P 
Sbjct  112  FVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPY  171

Query  147  YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGK  198
            Y +PELF  K Y+  K D+W+LG  +Y +      F+   + +L  R++ GK
Sbjct  172  YMSPELFSNKPYN-YKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGK  222


>gi|116051|sp|P24941|CDK2_HUMAN  Cell division protein kinase 2 (p33 protein kinase)
Length=298

 Score = 87.4 bits (215),  Expect = 4e-17
 Identities = 72/258 (27%), Positives = 116/258 (44%), Gaps = 9/258 (3%)

Query  16   IDKTQLDEENL---KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG-EIFD  71
            + K +LD E         RE+ ++K L HP+I++L  V+ TE  +YLV E+     + F 
Sbjct  32   LKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFM  91

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL  131
               A   +     +    Q++  + FCH   ++HRDLK +NLL++    IK+ADFG +  
Sbjct  92   DASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA  151

Query  132  FTPGQLLKTWCGSPP---YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
            F  G  ++T+        Y APE+  G +Y    VDIWSLG +   +V     F G +  
Sbjct  152  F--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI  209

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVL  248
            +   R+          +  G   +     +    A+    K       +   L+  ML  
Sbjct  210  DQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHY  269

Query  249  DPNKRLSMEQICKHKWMK  266
            DPNKR+S +    H + +
Sbjct  270  DPNKRISAKAALAHPFFQ  287


>gi|74762068|sp|Q9Y5S2|MRCKB_HUMAN  Serine/threonine-protein kinase MRCK beta (CDC42-binding protein 
kinase beta) (Myotonic dystrophy kinase-related CDC42-binding 
kinase beta) (Myotonic dystrophy protein kinase-like beta) 
(MRCK beta) (DMPK-like beta)
Length=1711

 Score = 87.0 bits (214),  Expect = 5e-17
 Identities = 60/201 (29%), Positives = 104/201 (51%), Gaps = 10/201 (4%)

Query  12   AIKIIDKTQLDEENLKKIFREVQ--IMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+KI++K ++ +      FRE +  ++   C   I  L+   + E  +YLV +Y  GG++
Sbjct  103  AMKILNKWEMLKRAETACFREERDVLVNGDCQ-WITALHYAFQDENHLYLVMDYYVGGDL  161

Query  70   FDHLVA-HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
               L     ++ E  AR    ++V A+   H  + VHRD+K +N+LLD N +I++ADFG 
Sbjct  162  LTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGS  221

Query  129  SNLFTPGQLLKT--WCGSPPYAAPELFEGKEYD----GPKVDIWSLGVVLYVLVCGALPF  182
                     +++    G+P Y +PE+ +  E      GP+ D WSLGV +Y ++ G  PF
Sbjct  222  CLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPF  281

Query  183  DGSTLQNLRARVLSGKFRIPF  203
               +L     ++++ + R  F
Sbjct  282  YAESLVETYGKIMNHEERFQF  302


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 23/82 (28%), Positives = 46/82 (56%), Gaps = 4/82 (4%)

Query  1210  EQLGPVTQEFWDNLEKETEGLRQ--EMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKV  1267
             E+L    +E  D  ++    L++  E+++ + E++A+ Q      + K +EEME+  QKV
Sbjct  554   ERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDK-EEEMEVATQKV  612

Query  1268  EPLRAELQEGARQKLHELQEKL  1289
             + +R E++  A +   EL+ +L
Sbjct  613   DAMRQEMRR-AEKLRKELEAQL  633


>gi|83305929|sp|Q96RU8|TRIB1_HUMAN  Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor 
induced protein 2) (GIG-2)
Length=372

 Score = 86.7 bits (213),  Expect = 6e-17
 Identities = 72/255 (28%), Positives = 111/255 (43%), Gaps = 34/255 (13%)

Query  41   HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC  100
            H +I  + +V+  E   Y+  E    G++  ++ +  R+ E+EA R FKQIV+AV  CH 
Sbjct  140  HSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ  198

Query  101  RNIVHRDLKAENLLL--DANLNIKIADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGK-  156
              IV  DLK    +   +    +++     +++       L    G P Y +PE+     
Sbjct  199  SAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTG  258

Query  157  EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSH  216
             Y G   D+WSLGV+LY L+ G  PF  S    L +++  G+F IP  +S          
Sbjct  259  TYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISP---------  309

Query  217  CNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDR  276
                        KA C        LIR +L  +P++RL+  +I  H W +        D 
Sbjct  310  ------------KARC--------LIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDS  349

Query  277  LIAECQQLKEERQVD  291
             I    Q+  E Q D
Sbjct  350  EIGTSDQIVPEYQED  364


>gi|14285498|sp|O15111|IKKA_HUMAN  Inhibitor of nuclear factor kappa-B kinase alpha subunit (I kappa-B 
kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) 
(I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix 
ubiquitous kinase) (Nuclear factor NFkappaB inhibitor kinase 
alpha) (NFKBIKA)
Length=745

 Score = 86.3 bits (212),  Expect = 8e-17
 Identities = 58/184 (31%), Positives = 91/184 (49%), Gaps = 13/184 (7%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY-----LVTEYA  64
            K+AIK   + +L  +N ++   E+QIMK L H ++++   V E   ++      L  EY 
Sbjct  40   KIAIKSC-RLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYC  98

Query  65   SGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD---AN  118
            SGG++   L        + E +       I + + + H   I+HRDLK EN++L      
Sbjct  99   SGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGK  158

Query  119  LNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
            +  KI D G++     G L  ++ G+  Y APELFE K Y    VD WS G +++  + G
Sbjct  159  IIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTA-TVDYWSFGTMVFECIAG  217

Query  179  ALPF  182
              PF
Sbjct  218  YRPF  221


>gi|462203|sp|P34947|GRK5_HUMAN  G protein-coupled receptor kinase 5 (G protein-coupled receptor 
kinase GRK5)
Length=590

 Score = 86.3 bits (212),  Expect = 8e-17
 Identities = 63/221 (28%), Positives = 104/221 (47%), Gaps = 10/221 (4%)

Query  20   QLDEENLKK------IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL  73
            +L+++ +KK         E QI++ +    ++ L    ET+  + LV    +GG++  H+
Sbjct  216  RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHI  275

Query  74   VAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL  131
               G    +E R  F   +I+  +   H  N V+RDLK EN+LLD   +I+I+D G +  
Sbjct  276  YNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVK  335

Query  132  FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLR  191
               G L++   G+  Y APE+   + Y G   D W LG ++Y ++ G  PF G   +  R
Sbjct  336  IPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKR  394

Query  192  ARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGC  232
              V           S  +     S C ++L  KD + + GC
Sbjct  395  EEVDRRVLETEEVYSHKFSEEAKSICKMLL-TKDAKQRLGC  434


>gi|30316115|sp|Q9BUB5|MKNK1_HUMAN  MAP kinase-interacting serine/threonine-protein kinase 1 (MAP 
kinase signal-integrating kinase 1) (Mnk1)
Length=465

 Score = 85.9 bits (211),  Expect = 1e-16
 Identities = 88/330 (26%), Positives = 132/330 (40%), Gaps = 89/330 (26%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTE  62
            + Q   + A+KII+K      +  ++FREV+ + +   + +I+ L +  E +   YLV E
Sbjct  68   SLQNGKEYAVKIIEKQA--GHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFE  125

Query  63   YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--------------------  102
               GG I  H+       E+EA R  + +  A+ F H ++                    
Sbjct  126  KLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAA  185

Query  103  ---------------------IVHRDLKAENLLLDANLNI---KIADFGF------SNLF  132
                                 I HRDLK EN+L ++   +   KI DF        +N  
Sbjct  186  PTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSC  245

Query  133  TPGQL--LKTWCGSPPYAAPELFE-----GKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            TP     L T CGS  Y APE+ E        YD  + D+WSLGVVLY+++ G  PF G 
Sbjct  246  TPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD-KRCDLWSLGVVLYIMLSGYPPFVG-  303

Query  186  TLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSI---------A  236
                       G  R             G  C V  N   + ++ G             +
Sbjct  304  -----HCGADCGWDR-------------GEVCRVCQNKLFESIQEGKYEFPDKDWAHISS  345

Query  237  ECEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
            E + LI  +LV D  +RLS  Q+ +H W++
Sbjct  346  EAKDLISKLLVRDAKQRLSAAQVLQHPWVQ  375


>gi|85700366|sp|P45984|MK09_HUMAN  Mitogen-activated protein kinase 9 (Stress-activated protein 
kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55)
Length=424

 Score = 85.5 bits (210),  Expect = 1e-16
 Identities = 65/280 (23%), Positives = 125/280 (44%), Gaps = 35/280 (12%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA  64
            VA+K + +   ++ + K+ +RE+ ++K + H +II L  V   ++       +YLV E  
Sbjct  52   VAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM  111

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA  124
                     V H  +  +       Q++  +   H   I+HRDLK  N+++ ++  +KI 
Sbjct  112  DANLC---QVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL  168

Query  125  DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
            DFG +       ++  +  +  Y APE+  G  Y    VDIWS+G ++  LV G + F G
Sbjct  169  DFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGELVKGCVIFQG  227

Query  185  ST-------------------LQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKD  225
            +                    ++ L+  V +     P +    +  L         + +D
Sbjct  228  TDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD  287

Query  226  KRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM  265
            K      +  ++   L+  MLV+DP+KR+S+++  +H ++
Sbjct  288  K------IKTSQARDLLSKMLVIDPDKRISVDEALRHPYI  321


>gi|20141386|sp|P43250|GRK6_HUMAN  G protein-coupled receptor kinase 6 (G protein-coupled receptor 
kinase GRK6)
Length=576

 Score = 85.1 bits (209),  Expect = 2e-16
 Identities = 65/221 (29%), Positives = 106/221 (47%), Gaps = 10/221 (4%)

Query  20   QLDEENLKK------IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL  73
            +L+++ +KK         E QI++ +    ++ L    ET+  + LV    +GG++  H+
Sbjct  216  KLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHI  275

Query  74   VAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL  131
               G+    EAR  F   +I   +   H   IV+RDLK EN+LLD + +I+I+D G +  
Sbjct  276  YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH  335

Query  132  FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLR  191
               GQ +K   G+  Y APE+ + + Y     D W+LG +LY ++ G  PF     +  R
Sbjct  336  VPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKR  394

Query  192  ARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGC  232
              V      +P   S  +     S C+ +L  KD   + GC
Sbjct  395  EEVERLVKEVPEEYSERFSPQARSLCSQLL-CKDPAERLGC  434


>gi|125474|sp|P06239|LCK_HUMAN  Proto-oncogene tyrosine-protein kinase LCK (p56-LCK) (Lymphocyte 
cell-specific protein-tyrosine kinase) (LSK) (T cell-specific 
protein-tyrosine kinase)
Length=509

 Score = 85.1 bits (209),  Expect = 2e-16
 Identities = 60/190 (31%), Positives = 93/190 (48%), Gaps = 14/190 (7%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KVA+K + +  +  +       E  +MK L H  ++RLY V+ T+  IY++TEY   G +
Sbjct  269  KVAVKSLKQGSMSPD---AFLAEANLMKQLQHQRLVRLYAVV-TQEPIYIITEYMENGSL  324

Query  70   FDHLVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
             D L      ++   +      QI   + F   RN +HRDL+A N+L+   L+ KIADFG
Sbjct  325  VDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFG  384

Query  128  FSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDG  184
             + L    +         P  + APE      +   K D+WS G++L  +V  G +P+ G
Sbjct  385  LARLIEDNEYTAREGAKFPIKWTAPEAINYGTFT-IKSDVWSFGILLTEIVTHGRIPYPG  443

Query  185  ST----LQNL  190
             T    +QNL
Sbjct  444  MTNPEVIQNL  453


>gi|57015279|sp|O14578|CTRO_HUMAN  Citron Rho-interacting kinase (CRIK) (Rho-interacting, serine/threonine-protein 
kinase 21)
Length=2027

 Score = 85.1 bits (209),  Expect = 2e-16
 Identities = 56/184 (30%), Positives = 92/184 (50%), Gaps = 9/184 (4%)

Query  12   AIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K++ K  L  +     F E + I+     P I +L    + +  +YLV EY  GG++ 
Sbjct  124  AMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLL  183

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  +  ++ E   +    +++ AV+  H    VHRD+K EN+L+D   +IK+ DFG +
Sbjct  184  SLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSA  243

Query  130  NLFTPGQLL--KTWCGSPPYAAPELF-----EGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
                  +++  K   G+P Y APE+      +GK   G   D WS+GV+ Y ++ G  PF
Sbjct  244  AKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPF  303

Query  183  DGST  186
               T
Sbjct  304  AEGT  307


 Score = 37.7 bits (86),  Expect = 0.033
 Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 13/120 (10%)

Query  1207  KLREQLGPVTQEFWDNLEK----ETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMEL  1262
             KL EQL  ++ +  D+ +K    E E   +E+S + EE K +++  L + Q   QE  E 
Sbjct  832   KLEEQLEKISHQ--DHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER-ES  888

Query  1263  YRQKVEPLRAELQEGARQKLHELQEKLSPLGEEM------RDRARAHVDALRTHLAPYSD  1316
                 ++  RA L+   RQ   EL+E  +   EE+      RD  +   DALR      +D
Sbjct  889   QLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD  948


>gi|114006|sp|P06727|APOA4_HUMAN  Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV)
Length=396

 Score = 85.1 bits (209),  Expect = 2e-16
 Identities = 55/229 (24%), Positives = 111/229 (48%), Gaps = 11/229 (4%)

Query  1157  DRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVT  1216
             D+V  +   Y   L ++ ++ V   + S L +QLN    D    V +    L+++L P  
Sbjct  25    DQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFA  84

Query  1217  QEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQE  1276
              E  + L K++E L++E+ K+LEE++A++ P+ ++  +K  + +   +Q++EP   +L+ 
Sbjct  85    TELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRT  144

Query  1277  GARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDelrqrlaarlealkeNGGAR  1336
                 +  +L+ +L+P  + M    R + D+L+  L P++DEL+ ++              
Sbjct  145   QVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKI-----------DQN  193

Query  1337  LAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYT  1385
             + E   + T +      K    +E+LR+ L P  +  +      LE  T
Sbjct  194   VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLT  242


 Score = 56.6 bits (135),  Expect = 7e-08
 Identities = 45/199 (22%), Positives = 87/199 (43%), Gaps = 26/199 (13%)

Query  1201  VTSTFSKLREQLGPVTQEF-----------WDNLEKETEGLRQEMSKDLEEVKAKVQPYL  1249
             V +   +LR QL P  Q               +L    + L+ ++ +++EE+K ++ PY 
Sbjct  146   VNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYA  205

Query  1250  DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRT  1309
             D+F+ K  + +E  R+ + P   + QE    +L  L  ++    EE++ R  A  + LR 
Sbjct  206   DEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQ  265

Query  1310  HLAPYSDelrqrlaarlealkeNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPV  1369
              LAP ++++R                 L        + L+ L       +E+ R+ + P 
Sbjct  266   RLAPLAEDVR---------------GNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPY  310

Query  1370  LESFKVSFLSALEEYTKKL  1388
              E+F  + +  +E+  +KL
Sbjct  311   GENFNKALVQQMEQLRQKL  329


 Score = 51.2 bits (121),  Expect = 3e-06
 Identities = 33/148 (22%), Positives = 75/148 (50%), Gaps = 9/148 (6%)

Query  1159  VKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQE  1218
             V++L        +D+      Q EG     + N + L     ++++  +LR++L P+ ++
Sbjct  216   VEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKA--RISASAEELRQRLAPLAED  273

Query  1219  FWDNLEKETEGLRQEMSK-------DLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLR  1271
                NL+  TEGL++ +++        +EE + +V+PY ++F K   ++ME  RQK+ P  
Sbjct  274   VRGNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHA  333

Query  1272  AELQEGARQKLHELQEKLSPLGEEMRDR  1299
              +++        +L++K++      +++
Sbjct  334   GDVEGHLSFLEKDLRDKVNSFFSTFKEK  361


 Score = 49.7 bits (117),  Expect = 8e-06
 Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query  1201  VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEM  1260
             +  T  +LR  L P  Q+  + L  + EGL  +M K+ EE+KA++    ++ +++     
Sbjct  212   IDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLA  271

Query  1261  ELYR-------QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAP  1313
             E  R       + ++   AEL     Q++ E + ++ P GE         ++ LR  L P
Sbjct  272   EDVRGNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGP  331

Query  1314  YS  1315
             ++
Sbjct  332   HA  333


>gi|125351|sp|P16591|FER_HUMAN  Proto-oncogene tyrosine-protein kinase FER (p94-FER) (c-FER)
Length=822

 Score = 84.0 bits (206),  Expect = 4e-16
 Identities = 61/204 (29%), Positives = 93/204 (45%), Gaps = 18/204 (8%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            T +    VA+K   K  L +E   K  +E +I+K   HP+I++L  V    + +Y++ E 
Sbjct  581  TLKDKTSVAVKTC-KEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMEL  639

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIV-------TAVYFCHCRNIVHRDLKAENLLLD  116
             SGG+    L        K+   K KQ+V         + +   +N +HRDL A N L+ 
Sbjct  640  VSGGDFLTFL------RRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVG  693

Query  117  ANLNIKIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-  173
             N  +KI+DFG S     G    +     P  + APE      Y   + D+WS G++L+ 
Sbjct  694  ENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSS-ESDVWSFGILLWE  752

Query  174  VLVCGALPFDGSTLQNLRARVLSG  197
                G  P+ G T Q  R +V  G
Sbjct  753  TFSLGVCPYPGMTNQQAREQVERG  776


>gi|1169745|sp|P42685|FRK_HUMAN  Tyrosine-protein kinase FRK (Nuclear tyrosine protein kinase 
RAK)
Length=505

 Score = 84.0 bits (206),  Expect = 4e-16
 Identities = 59/206 (28%), Positives = 100/206 (48%), Gaps = 25/206 (12%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K +    +D  +     RE QIMK L HP +I+LY V   E  IY++TE    G + 
Sbjct  259  VAVKTLKPGSMDPNDF---LREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQ  315

Query  71   DHLV--AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
            ++L      ++   +      Q+ + + +   RN +HRDL A N+L+  +   K+ADFG 
Sbjct  316  EYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGL  375

Query  129  SNLFTPG-----------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLV  176
            + +F              +L   W       APE     ++   K D+WS G++LY ++ 
Sbjct  376  ARVFKVDNEDIYESRHEIKLPVKW------TAPEAIRSNKF-SIKSDVWSFGILLYEIIT  428

Query  177  CGALPFDGSTLQNLRARVLSGKFRIP  202
             G +P+ G T   +  ++L+  +R+P
Sbjct  429  YGKMPYSGMTGAQV-IQMLAQNYRLP  453


>gi|2507195|sp|P45983|MK08_HUMAN  Mitogen-activated protein kinase 8 (Stress-activated protein 
kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46)
Length=427

 Score = 83.6 bits (205),  Expect = 5e-16
 Identities = 69/283 (24%), Positives = 130/283 (45%), Gaps = 37/283 (13%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA  64
            VAIK + +   ++ + K+ +RE+ +MK + H +II L  V   ++       +Y+V E  
Sbjct  52   VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELM  111

Query  65   SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK  122
                 ++    + H RM+         Q++  +   H   I+HRDLK  N+++ ++  +K
Sbjct  112  DANLCQVIQMELDHERMSYL-----LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK  166

Query  123  IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            I DFG +       ++  +  +  Y APE+  G  Y    VD+WS+G ++  +VC  + F
Sbjct  167  ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK-ENVDLWSVGCIMGEMVCHKILF  225

Query  183  DGSTLQNLRARVLSG-KFRIPFFMS----------------TGY-FHLLGSHCNVVLNAK  224
             G    +   +V+       P FM                  GY F  L        +++
Sbjct  226  PGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSE  285

Query  225  DKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKL  267
              +LKA     ++   L+  MLV+D +KR+S+++  +H ++ +
Sbjct  286  HNKLKA-----SQARDLLSKMLVIDASKRISVDEALQHPYINV  323


>gi|34222826|sp|Q86UE8|TLK2_HUMAN  Serine/threonine-protein kinase tousled-like 2 (Tousled-like 
kinase 2) (PKU-alpha)
Length=772

 Score = 83.2 bits (204),  Expect = 7e-16
 Identities = 72/194 (37%), Positives = 96/194 (49%), Gaps = 22/194 (11%)

Query  11   VAIKI--IDKTQLDE--ENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIYL-VTEYA  64
            VA+KI  ++K   DE  EN  K   RE +I K L HP I++LY     +   +  V EY 
Sbjct  488  VAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYC  547

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH--CRNIVHRDLKAENLLL---DANL  119
             G ++  +L  H  M+EKEAR    QIV A+ + +     I+H DLK  N+LL    A  
Sbjct  548  EGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACG  607

Query  120  NIKIADFGFSNLFTPG--------QLLKTWCGSPPYAAPELF-EGKEYD--GPKVDIWSL  168
             IKI DFG S +            +L     G+  Y  PE F  GKE      KVD+WS+
Sbjct  608  EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSV  667

Query  169  GVVLYVLVCGALPF  182
            GV+ Y  + G  PF
Sbjct  668  GVIFYQCLYGRKPF  681


>gi|56749457|sp|Q15208|STK38_HUMAN  Serine/threonine-protein kinase 38 (NDR1 protein kinase) (Nuclear 
Dbf2-related kinase 1)
Length=465

 Score = 82.8 bits (203),  Expect = 9e-16
 Identities = 60/230 (26%), Positives = 107/230 (46%), Gaps = 40/230 (17%)

Query  12   AIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+ K   L++E +  I  E  I+       +++++   + +  +YL+ E+  GG++ 
Sbjct  116  AMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMM  175

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG---  127
              L+    + E+E +    + V A+   H    +HRD+K +NLLLD+  ++K++DFG   
Sbjct  176  TLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCT  235

Query  128  -----------------------FSNLFTPGQLLKTW-----------CGSPPYAAPELF  153
                                   F N+ +  +  +TW            G+P Y APE+F
Sbjct  236  GLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKA-ETWKRNRRQLAFSTVGTPDYIAPEVF  294

Query  154  EGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF  203
                Y+    D WSLGV++Y ++ G  PF   T Q    +V++ K  + F
Sbjct  295  MQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTF  343


>gi|19857975|sp|P29322|EPHA8_HUMAN  Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor 
EEK) (EPH- and ELK-related kinase) (HEK3)
Length=1005

 Score = 82.4 bits (202),  Expect = 1e-15
 Identities = 63/198 (31%), Positives = 95/198 (47%), Gaps = 9/198 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K    E   +    E  IM    HP+IIRL  V+   R+  +VTEY   G + 
Sbjct  664  VAIKAL-KAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLD  722

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  H G+    +     + +   + +      VHRDL A N+L+D+NL  K++DFG S
Sbjct  723  TFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLS  782

Query  130  NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
             +    P     T  G  P  + APE    + +     D+WS GVV++ VL  G  P+  
Sbjct  783  RVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSAS-DVWSFGVVMWEVLAYGERPYWN  841

Query  185  STLQNLRARVLSGKFRIP  202
             T +++ + V  G +R+P
Sbjct  842  MTNRDVISSVEEG-YRLP  858


>gi|85681908|sp|P00519|ABL1_HUMAN  Proto-oncogene tyrosine-protein kinase ABL1 (p150) (c-ABL) (Abelson 
murine leukemia viral oncogene homolog 1)
Length=1130

 Score = 82.4 bits (202),  Expect = 1e-15
 Identities = 55/191 (28%), Positives = 95/191 (49%), Gaps = 11/191 (5%)

Query  6    QFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS  65
            +++  VA+K + +  ++ E   K   E  +MK + HP++++L  V   E   Y++TE+ +
Sbjct  263  KYSLTVAVKTLKEDTMEVEEFLK---EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMT  319

Query  66   GGEIFDHLVAHGRMAEKEARRKFK--QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI  123
             G + D+L    R         +   QI +A+ +   +N +HRDL A N L+  N  +K+
Sbjct  320  YGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKV  379

Query  124  ADFGFSNLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGA  179
            ADFG S L T G       G+     + APE     ++   K D+W+ GV+L+ +   G 
Sbjct  380  ADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKF-SIKSDVWAFGVLLWEIATYGM  437

Query  180  LPFDGSTLQNL  190
             P+ G  L  +
Sbjct  438  SPYPGIDLSQV  448


>gi|74759739|sp|Q8IZL9|CCRK_HUMAN  Cell cycle-related kinase (Cyclin-kinase activating kinase p42) 
(CDK-activating kinase p42) (CAK-kinase p42)
Length=346

 Score = 82.4 bits (202),  Expect = 1e-15
 Identities = 55/179 (30%), Positives = 93/179 (51%), Gaps = 7/179 (3%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTEYASG--G  67
            VA+K +   +L++    +  RE++ + +M  + ++++L  V        L  E+      
Sbjct  30   VALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLA  89

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
            E+  H  A   +A+ + +   + ++  V FCH  NIVHRDLK  NLL+ A+  +KIADFG
Sbjct  90   EVVRH--AQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFG  147

Query  128  FSNLFTP--GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
             + +F+P   +L      +  Y APEL  G       VD+WS+G ++  L+ G+  F G
Sbjct  148  LARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPG  206


>gi|12643825|sp|Q9NYV4|CD2L7_HUMAN  Cell division cycle 2-related protein kinase 7 (CDC2-related 
protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) 
(CrkRS)
Length=1490

 Score = 82.4 bits (202),  Expect = 1e-15
 Identities = 73/284 (25%), Positives = 126/284 (44%), Gaps = 50/284 (17%)

Query  16    IDKTQLDEENLK---KIFREVQIMKMLCHPHIIRLYQVMETER----------MIYLVTE  62
             + K +LD E         RE++I++ L H  ++ + +++  ++            YLV E
Sbjct  755   LKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFE  814

Query  63    YASGGEIFDH----LVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD  116
             Y       DH    L+  G    +E   +   KQ++  + +CH +N +HRD+K  N+LL+
Sbjct  815   Y------MDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLN  868

Query  117   ANLNIKIADFGFSNLFT-------PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLG  169
              +  IK+ADFG + L+          +++  W     Y  PEL  G+E   P +D+WS G
Sbjct  869   NSGQIKLADFGLARLYNSEESRPYTNKVITLW-----YRPPELLLGEERYTPAIDVWSCG  923

Query  170   VVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF------FMSTGYFHLLGSHCNVVLNA  223
              +L  L     P   + L+  +  ++S     P        +   YF+ +          
Sbjct  924   CILGELFT-KKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPK-----KQ  977

Query  224   KDKRLKAGCLSIAECE-HLIRHMLVLDPNKRLSMEQICKHKWMK  266
               +RL+     I      L+ HML LDP+KR + EQ  +  ++K
Sbjct  978   YRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK  1021


>gi|8928302|sp|Q13882|PTK6_HUMAN  Tyrosine-protein kinase 6 (Breast tumor kinase) (Tyrosine-protein 
kinase BRK)
Length=451

 Score = 82.0 bits (201),  Expect = 2e-15
 Identities = 58/197 (29%), Positives = 95/197 (48%), Gaps = 8/197 (4%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIK+I +  L  + + +   E+Q MK L H HI+ LY V+     +Y++TE  + G +
Sbjct  215  QVAIKVISRDNLLHQQMLQ--SEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSL  272

Query  70   FDHLVAHGR--MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
             + L       +   E      Q+   + +   +N +HRDL A N+L+  N   K+ DFG
Sbjct  273  LELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFG  332

Query  128  FSNLFTPGQLLKTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS  185
             + L      L      P  + APE      Y   K D+WS G++L+ +   G +P+ G 
Sbjct  333  LARLIKEDVYLSHDHNIPYKWTAPEALSRGHY-STKSDVWSFGILLHEMFSRGQVPYPGM  391

Query  186  TLQNLRARVLSGKFRIP  202
            +      RV +G +R+P
Sbjct  392  SNHEAFLRVDAG-YRMP  407


>gi|1351326|sp|P42681|TXK_HUMAN  Tyrosine-protein kinase TXK
Length=527

 Score = 82.0 bits (201),  Expect = 2e-15
 Identities = 56/197 (28%), Positives = 104/197 (52%), Gaps = 11/197 (5%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAIK I++  + EE+      E ++M  L H  +++LY V    + +Y+VTE+   G +
Sbjct  295  QVAIKAINEGSMSEEDF---IEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCL  351

Query  70   FDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
             ++L  + G++ ++      + I   + +      +HRDL A N L+ +   +KI+DFG 
Sbjct  352  LNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGM  411

Query  129  SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG-  184
            +      + + ++    P  ++ PE+F   +Y   K D+WS GV+++ V   G +PF+  
Sbjct  412  TRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSS-KSDVWSFGVLMWEVFTEGKMPFENK  470

Query  185  STLQNLRARVLSGKFRI  201
            S LQ + A  +S  FR+
Sbjct  471  SNLQVVEA--ISEGFRL  485


>gi|12643358|sp|O94804|STK10_HUMAN  Serine/threonine-protein kinase 10 (Lymphocyte-oriented kinase)
Length=968

 Score = 82.0 bits (201),  Expect = 2e-15
 Identities = 57/180 (31%), Positives = 97/180 (53%), Gaps = 12/180 (6%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            K    +  A  A K+I+     EE L+    E++I+    HP+I++L      +  ++++
Sbjct  52   KAKNKETGALAAAKVIETKS--EEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIM  109

Query  61   TEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL  119
             E+  GG +   ++   R + E + +   +Q++ A+ F H + I+HRDLKA N+L+    
Sbjct  110  IEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEG  169

Query  120  NIKIADFGFS--NLFTPGQLLKTWCGSPPYAAPEL-----FEGKEYDGPKVDIWSLGVVL  172
            +I++ADFG S  NL T  Q   ++ G+P + APE+      +   YD  K DIWSLG+ L
Sbjct  170  DIRLADFGVSAKNLKTL-QKRDSFIGTPYWMAPEVVMCETMKDTPYD-YKADIWSLGITL  227


 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query  1205  FSKLREQLGPVTQEFWDNLEKETEGLRQE-MSKDLEEVKAKVQPYLDDFQKKWQEEMELY  1263
             +++ +EQL  + +E  + +EK     R+E M + +EE   K Q    DF  K +E++EL 
Sbjct  650   YTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELA  709

Query  1264  RQKV-EPLRAELQEGARQKLHELQEKL  1289
              +++    R E+ +  R+ L + QE L
Sbjct  710   MKRLTTDNRREICDKERECLMKKQELL  736


>gi|125711|sp|P12931|SRC_HUMAN  Proto-oncogene tyrosine-protein kinase Src (p60-Src) (c-Src) 
(pp60c-src)
Length=536

 Score = 81.6 bits (200),  Expect = 2e-15
 Identities = 64/204 (31%), Positives = 100/204 (49%), Gaps = 11/204 (5%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            T+    +VAIK +    +  E      +E Q+MK L H  +++LY V+ +E  IY+VTEY
Sbjct  288  TWNGTTRVAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEY  343

Query  64   ASGGEIFDHLVAH-GRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
             S G + D L    G+     +      QI + + +    N VHRDL+A N+L+  NL  
Sbjct  344  MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC  403

Query  122  KIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-G  178
            K+ADFG + L    +         P  + APE      +   K D+WS G++L  L   G
Sbjct  404  KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILLTELTTKG  462

Query  179  ALPFDGSTLQNLRARVLSGKFRIP  202
             +P+ G   + +  +V  G +R+P
Sbjct  463  RVPYPGMVNREVLDQVERG-YRMP  485


>gi|1168268|sp|P42684|ABL2_HUMAN  Tyrosine-protein kinase ABL2 (Abelson murine leukemia viral oncogene 
homolog 2) (Tyrosine kinase ARG)
Length=1182

 Score = 81.6 bits (200),  Expect = 2e-15
 Identities = 57/191 (29%), Positives = 93/191 (48%), Gaps = 11/191 (5%)

Query  6    QFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS  65
            +++  VA+K + +  ++ E   K   E  +MK + HP++++L  V   E   Y+VTEY  
Sbjct  309  KYSLTVAVKTLKEDTMEVEEFLK---EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMP  365

Query  66   GGEIFDHLVAHGRMAEKEARRKFK--QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI  123
             G + D+L    R         +   QI +A+ +   +N +HRDL A N L+  N  +K+
Sbjct  366  YGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKV  425

Query  124  ADFGFSNLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGA  179
            ADFG S L T G       G+     + APE      +   K D+W+ GV+L+ +   G 
Sbjct  426  ADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNTF-SIKSDVWAFGVLLWEIATYGM  483

Query  180  LPFDGSTLQNL  190
             P+ G  L  +
Sbjct  484  SPYPGIDLSQV  494


>gi|34223086|sp|Q9UKI8|TLK1_HUMAN  Serine/threonine-protein kinase tousled-like 1 (Tousled-like 
kinase 1) (PKU-beta)
Length=766

 Score = 81.3 bits (199),  Expect = 3e-15
 Identities = 70/193 (36%), Positives = 94/193 (48%), Gaps = 19/193 (9%)

Query  9    AKVAIKIIDKTQLDE--ENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIYL-VTEYA  64
            A V I  ++K+  DE  EN  K   RE +I K L HP I++LY     +   +  V EY 
Sbjct  482  AAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYC  541

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH--CRNIVHRDLKAENLLL---DANL  119
             G ++  +L  H  M+EKEAR    QIV A+ + +     I+H DLK  N+LL    A  
Sbjct  542  EGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACG  601

Query  120  NIKIADFGFSNLFTPG-------QLLKTWCGSPPYAAPELF-EGKEYD--GPKVDIWSLG  169
             IKI DFG S +            L     G+  Y  PE F  GKE      KVD+WS+G
Sbjct  602  EIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVG  661

Query  170  VVLYVLVCGALPF  182
            V+ +  + G  PF
Sbjct  662  VIFFQCLYGRKPF  674


>gi|74762638|sp|Q92519|TRIB2_HUMAN  Tribbles homolog 2 (TRB-2)
Length=343

 Score = 81.3 bits (199),  Expect = 3e-15
 Identities = 62/228 (27%), Positives = 102/228 (44%), Gaps = 34/228 (14%)

Query  41   HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC  100
            H +I ++ +++  E   Y+  E  S G++   +    ++ E+EA R F QI +AV  CH 
Sbjct  110  HSNINQITEIILGETKAYVFFE-RSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHD  168

Query  101  RNIVHRDLKAENLLL--DANLNIKIADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGK-  156
              +V RDLK    +   +    +K+     + +       L    G P Y +PE+     
Sbjct  169  GGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSG  228

Query  157  EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSH  216
             Y G   D+WSLGV+LY ++ G  PF      +L +++  G+F IP  +S          
Sbjct  229  SYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSP---------  279

Query  217  CNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKW  264
                        KA C        LIR +L  +P++RL+ ++I  H W
Sbjct  280  ------------KAKC--------LIRSILRREPSERLTSQEILDHPW  307


>gi|585361|sp|Q08881|ITK_HUMAN  Tyrosine-protein kinase ITK/TSK (T-cell-specific kinase) (Tyrosine-protein 
kinase Lyk) (Kinase EMT)
Length=620

 Score = 81.3 bits (199),  Expect = 3e-15
 Identities = 62/214 (28%), Positives = 104/214 (48%), Gaps = 12/214 (5%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KVAIK I +  + EE+      E ++M  L HP +++LY V   +  I LV E+   G +
Sbjct  387  KVAIKTIREGAMSEEDF---IEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCL  443

Query  70   FDHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
             D+L    G  A +        +   + +     ++HRDL A N L+  N  IK++DFG 
Sbjct  444  SDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGM  503

Query  129  SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS  185
            +      Q   +     P  +A+PE+F    Y   K D+WS GV+++ V   G +P++  
Sbjct  504  TRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS-KSDVWSFGVLMWEVFSEGKIPYENR  562

Query  186  TLQNLRARVLSGKFRI--PFFMSTGYFHLLGSHC  217
            +   +   + +G FR+  P   ST  + ++ +HC
Sbjct  563  SNSEVVEDISTG-FRLYKPRLASTHVYQIM-NHC  594


>gi|20178302|sp|Q07002|PCTK3_HUMAN  Serine/threonine-protein kinase PCTAIRE-3 (PCTAIRE-motif protein 
kinase 3)
Length=472

 Score = 81.3 bits (199),  Expect = 3e-15
 Identities = 51/162 (31%), Positives = 85/162 (52%), Gaps = 7/162 (4%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG--EIFDHLVAHGRMAEKEARRKF  88
            REV ++K L H +I+ L+ ++ T+R + LV EY      +  DH      M+    +   
Sbjct  187  REVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDH--CGNLMSMHNVKIFM  244

Query  89   KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL-FTPGQLLKTWCGSPPY  147
             Q++  + +CH R I+HRDLK +NLL++    +K+ADFG +     P +       +  Y
Sbjct  245  FQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWY  304

Query  148  AAPELFEGK-EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
              P++  G  EY  P +D+W +G + Y +  G   F GST++
Sbjct  305  RPPDVLLGSTEYSTP-IDMWGVGCIHYEMATGRPLFPGSTVK  345


>gi|8488988|sp|Q13233|M3K1_HUMAN  Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase 
kinase 1) (MEK kinase 1) (MEKK 1)
Length=1495

 Score = 80.9 bits (198),  Expect = 3e-15
 Identities = 50/188 (26%), Positives = 90/188 (47%), Gaps = 7/188 (3%)

Query  8     AAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
             A K    + + +   EE ++ +  E+++M  L HP+IIR+      +    L  E+ +GG
Sbjct  1253  AVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGG  1312

Query  68    EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA-NLNIKIADF  126
              +   L  +G   E       +Q++  + + H   I+HRD+K  NLL+D+    ++IADF
Sbjct  1313  SVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADF  1372

Query  127   GFSNLFT-----PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP  181
             G +          G+      G+  + APE+  G++Y G   D+WS+G  +  + C   P
Sbjct  1373  GAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQY-GRSCDVWSVGCAIIEMACAKPP  1431

Query  182   FDGSTLQN  189
             ++     N
Sbjct  1432  WNAEKHSN  1439


>gi|1730068|sp|P10398|ARAF_HUMAN  A-Raf proto-oncogene serine/threonine-protein kinase (A-raf-1) 
(Proto-oncogene Pks)
Length=606

 Score = 80.9 bits (198),  Expect = 3e-15
 Identities = 51/178 (28%), Positives = 95/178 (53%), Gaps = 7/178 (3%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K++  +Q   E  +    E+Q+++   H +I+ L+    T     ++T++  G  ++
Sbjct  333  VAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLY  391

Query  71   DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             HL VA  R    +     +Q    + + H +NI+HRDLK+ N+ L   L +KI DFG +
Sbjct  392  HHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLA  451

Query  130  NL---FTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPF  182
             +   ++  Q L+   GS  + A E+   ++ +    + D+++ GVVLY L+ G+LP+
Sbjct  452  TVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPY  509


>gi|400274|sp|Q02750|MP2K1_HUMAN  Dual specificity mitogen-activated protein kinase kinase 1 (MAP 
kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK 
kinase 1) (MEK1)
Length=393

 Score = 80.9 bits (198),  Expect = 3e-15
 Identities = 68/269 (25%), Positives = 124/269 (46%), Gaps = 36/269 (13%)

Query  28   KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRK  87
            +I RE+Q++     P+I+  Y    ++  I +  E+  GG +   L   GR+ E+   + 
Sbjct  110  QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV  169

Query  88   FKQIVTAV-YFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLL----KTWC  142
               ++  + Y      I+HRD+K  N+L+++   IK+ DFG S     GQL+     ++ 
Sbjct  170  SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSFV  224

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---DGSTLQNLRARVLSG--  197
            G+  Y +PE  +G  Y   + DIWS+G+ L  +  G  P    D   L+ +    + G  
Sbjct  225  GTRSYMSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA  283

Query  198  -----KFRIPFFMSTGY----------FHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLI  242
                 + R P    + Y          F LL    + ++N    +L +G  S+ E +  +
Sbjct  284  AETPPRPRTPGRPLSSYGMDSRPPMAIFELL----DYIVNEPPPKLPSGVFSL-EFQDFV  338

Query  243  RHMLVLDPNKRLSMEQICKHKWMKLGDAD  271
               L+ +P +R  ++Q+  H ++K  DA+
Sbjct  339  NKCLIKNPAERADLKQLMVHAFIKRSDAE  367


>gi|20141296|sp|P08631|HCK_HUMAN  Tyrosine-protein kinase HCK (p59-HCK/p60-HCK) (Hemopoietic cell 
kinase)
Length=526

 Score = 80.9 bits (198),  Expect = 3e-15
 Identities = 61/206 (29%), Positives = 100/206 (48%), Gaps = 15/206 (7%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            T+    KVA+K +    +  E       E  +MK L H  +++L+ V+ T+  IY++TE+
Sbjct  280  TYNKHTKVAVKTMKPGSMSVE---AFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEF  335

Query  64   ASGGEIFDHLVAHGRMAEKEARRKF----KQIVTAVYFCHCRNIVHRDLKAENLLLDANL  119
             + G + D L +      K+   K      QI   + F   RN +HRDL+A N+L+ A+L
Sbjct  336  MAKGSLLDFLKSDE--GSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL  393

Query  120  NIKIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC  177
              KIADFG + +    +         P  + APE      +   K D+WS G++L  +V 
Sbjct  394  VCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFT-IKSDVWSFGILLMEIVT  452

Query  178  -GALPFDGSTLQNLRARVLSGKFRIP  202
             G +P+ G +   +  R L   +R+P
Sbjct  453  YGRIPYPGMSNPEV-IRALERGYRMP  477


>gi|266425|sp|Q00536|PCTK1_HUMAN  Serine/threonine-protein kinase PCTAIRE-1 (PCTAIRE-motif protein 
kinase 1)
Length=496

 Score = 80.5 bits (197),  Expect = 4e-15
 Identities = 46/160 (28%), Positives = 86/160 (53%), Gaps = 3/160 (1%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK-  89
            REV ++K L H +I+ L+ ++ TE+ + LV EY    ++  +L   G +      + F  
Sbjct  210  REVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLF  268

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFT-PGQLLKTWCGSPPYA  148
            Q++  + +CH + ++HRDLK +NLL++    +K+ADFG +   + P +       +  Y 
Sbjct  269  QLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYR  328

Query  149  APELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
             P++  G      ++D+W +G + Y +  G   F GST++
Sbjct  329  PPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVE  368


>gi|14285497|sp|O14920|IKKB_HUMAN  Inhibitor of nuclear factor kappa B kinase beta subunit (I-kappa-B-kinase 
beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 
2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) 
(NFKBIKB)
Length=756

 Score = 80.5 bits (197),  Expect = 4e-15
 Identities = 56/185 (30%), Positives = 90/185 (48%), Gaps = 14/185 (7%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMI------YLVTEY  63
            ++AIK   + +L   N ++   E+QIM+ L HP+++    V E  + +       L  EY
Sbjct  40   QIAIKQC-RQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEY  98

Query  64   ASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DA  117
              GG++  +L        + E         I +A+ + H   I+HRDLK EN++L   + 
Sbjct  99   CQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQ  158

Query  118  NLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC  177
             L  KI D G++     G L  ++ G+  Y APEL E ++Y    VD WS G + +  + 
Sbjct  159  RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT-VTVDYWSFGTLAFECIT  217

Query  178  GALPF  182
            G  PF
Sbjct  218  GFRPF  222


>gi|50403720|sp|P15056|BRAF1_HUMAN  B-Raf proto-oncogene serine/threonine-protein kinase (p94) (v-Raf 
murine sarcoma viral oncogene homolog B1)
Length=766

 Score = 80.5 bits (197),  Expect = 4e-15
 Identities = 59/233 (25%), Positives = 114/233 (48%), Gaps = 25/233 (10%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K+++ T    + L+    EV +++   H +I+ L+    T+  + +VT++  G  ++
Sbjct  480  VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLY  538

Query  71   DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             HL +   +    +     +Q    + + H ++I+HRDLK+ N+ L  +L +KI DFG +
Sbjct  539  HHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA  598

Query  130  NL---FTPGQLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
             +   ++     +   GS  + APE+   + K     + D+++ G+VLY L+ G LP+  
Sbjct  599  TVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN  658

Query  185  STLQNLRARVLSGKFRIPFFMSTGY----FHLLGSHCNVVLNAKDKRLKAGCL  233
                      ++ + +I F +  GY       + S+C   +    KRL A CL
Sbjct  659  ----------INNRDQIIFMVGRGYLSPDLSKVRSNCPKAM----KRLMAECL  697


>gi|68052263|sp|O43283|M3K13_HUMAN  Mitogen-activated protein kinase kinase kinase 13 (Mixed lineage 
kinase) (MLK) (Leucine zipper-bearing kinase)
Length=966

 Score = 80.5 bits (197),  Expect = 4e-15
 Identities = 49/171 (28%), Positives = 89/171 (52%), Gaps = 5/171 (2%)

Query  16   IDKTQLDEENLKKIFRE----VQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            + K + +E  +KK+  +    ++ ++ L HP+II    V        ++ EY + G++++
Sbjct  184  LGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYE  243

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL  131
             L A  ++  +        I + + + H   I+HRDLK+ N+L+     +KI+DFG S  
Sbjct  244  VLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKE  303

Query  132  FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
             +      ++ G+  + APE+    E    KVDIWS GVVL+ L+ G +P+
Sbjct  304  LSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSFGVVLWELLTGEIPY  353


>gi|27805732|sp|Q9H3Y6|SRMS_HUMAN  Tyrosine-protein kinase Srms
Length=488

 Score = 80.5 bits (197),  Expect = 4e-15
 Identities = 61/197 (30%), Positives = 94/197 (47%), Gaps = 10/197 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK+I    +   +L K   E+Q +K L H  +IRL+ V      +Y+VTE    G + 
Sbjct  255  VAIKVIKSANMKLTDLAK---EIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQ  311

Query  71   DHL-VAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
              L    GR         F  Q+   + +   + +VHRDL A N+L+D  L  K+ADFG 
Sbjct  312  AFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGL  371

Query  129  SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS  185
            + L        +     P  + APE    + +   K D+WS GV+L+ V   G  P++G 
Sbjct  372  ARLLKDDIYSPSSSSKIPVKWTAPEAANYRVF-SQKSDVWSFGVLLHEVFTYGQCPYEGM  430

Query  186  TLQNLRARVLSGKFRIP  202
            T      +++ G +R+P
Sbjct  431  TNHETLQQIMRG-YRLP  446


>gi|59803097|sp|Q00537|PCTK2_HUMAN  Serine/threonine-protein kinase PCTAIRE-2 (PCTAIRE-motif protein 
kinase 2)
Length=523

 Score = 80.1 bits (196),  Expect = 6e-15
 Identities = 45/161 (27%), Positives = 86/161 (53%), Gaps = 3/161 (1%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK-  89
            REV ++K L H +I+ L+ ++ T++ + LV EY    ++  ++   G +      + F  
Sbjct  237  REVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDK-DLKQYMDDCGNIMSMHNVKLFLY  295

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL-FTPGQLLKTWCGSPPYA  148
            QI+  + +CH R ++HRDLK +NLL++    +K+ADFG +     P +       +  Y 
Sbjct  296  QILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYR  355

Query  149  APELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN  189
             P++  G      ++D+W +G + + +  G   F GST+++
Sbjct  356  PPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVED  396


>gi|46577700|sp|Q13188|STK3_HUMAN  Serine/threonine-protein kinase 3 (STE20-like kinase MST2) (MST-2) 
(Mammalian STE20-like protein kinase 2) (Serine/threonine-protein 
kinase Krs-1)
Length=491

 Score = 79.7 bits (195),  Expect = 8e-15
 Identities = 67/290 (23%), Positives = 125/290 (43%), Gaps = 32/290 (11%)

Query  23   EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAE  81
            E +L++I +E+ IM+    P++++ Y        +++V EY   G + D +    + + E
Sbjct  61   ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE  120

Query  82   KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLK-T  140
             E     K  +  + + H    +HRD+KA N+LL+   + K+ADFG +   T     + T
Sbjct  121  DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT  180

Query  141  WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR  200
              G+P + APE+ +   Y+    DIWSLG+    +  G  P+  + +  +RA  +     
Sbjct  181  VIGTPFWMAPEVIQEIGYN-CVADIWSLGITSIEMAEGKPPY--ADIHPMRAIFMIPTNP  237

Query  201  IPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQIC  260
             P F                            L   +    ++  LV +P +R +  Q+ 
Sbjct  238  PPTFRKPE------------------------LWSDDFTDFVKKCLVKNPEQRATATQLL  273

Query  261  KHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ  310
            +H ++K          LI E  ++K +R  +   E   L  E+   D+++
Sbjct  274  QHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRE---LEEEEENSDEDE  320


>gi|2507196|sp|P53779|MK10_HUMAN  Mitogen-activated protein kinase 10 (Stress-activated protein 
kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12)
Length=464

 Score = 79.7 bits (195),  Expect = 8e-15
 Identities = 73/282 (25%), Positives = 127/282 (45%), Gaps = 35/282 (12%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA  64
            VAIK + +   ++ + K+ +RE+ +MK + H +II L  V   ++       +YLV E  
Sbjct  90   VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM  149

Query  65   SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK  122
                 ++    + H RM+         Q++  +   H   I+HRDLK  N+++ ++  +K
Sbjct  150  DANLCQVIQMELDHERMSYL-----LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK  204

Query  123  IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            I DFG +       ++  +  +  Y APE+  G  Y    VDIWS+G ++  +V   + F
Sbjct  205  ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILF  263

Query  183  DGSTLQNLRARVLSG-KFRIPFFMSTGYFHLLGSHCNVVLNAKD------KRLKAGCLSI  235
             G    +   +V+       P FM      L  +  N V N          +L    L  
Sbjct  264  PGRDYIDQWNKVIEQLGTPCPEFMK----KLQPTVRNYVENRPKYAGLTFPKLFPDSLFP  319

Query  236  AECEH----------LIRHMLVLDPNKRLSMEQICKHKWMKL  267
            A+ EH          L+  MLV+DP KR+S++   +H ++ +
Sbjct  320  ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV  361


>gi|125370|sp|P06241|FYN_HUMAN  Proto-oncogene tyrosine-protein kinase Fyn (p59-Fyn) (Protooncogene 
Syn) (SLK)
Length=537

 Score = 79.7 bits (195),  Expect = 8e-15
 Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 11/204 (5%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            T+    KVAIK +    +  E+      E QIMK L H  +++LY V+ +E  IY+VTEY
Sbjct  289  TWNGNTKVAIKTLKPGTMSPESF---LEEAQIMKKLKHDKLVQLYAVV-SEEPIYIVTEY  344

Query  64   ASGGEIFDHLV-AHGRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
             + G + D L    GR  +         Q+   + +    N +HRDL++ N+L+   L  
Sbjct  345  MNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLIC  404

Query  122  KIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-G  178
            KIADFG + L    +         P  + APE      +   K D+WS G++L  LV  G
Sbjct  405  KIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILLTELVTKG  463

Query  179  ALPFDGSTLQNLRARVLSGKFRIP  202
             +P+ G   + +  +V  G +R+P
Sbjct  464  RVPYPGMNNREVLEQVERG-YRMP  486


>gi|37537965|sp|Q8TDX7|NEK7_HUMAN  Serine/threonine-protein kinase Nek7 (NimA-related protein kinase 
7)
Length=302

 Score = 79.7 bits (195),  Expect = 8e-15
 Identities = 47/173 (27%), Positives = 85/173 (49%), Gaps = 8/173 (4%)

Query  21   LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR--  78
            +D +      +E+ ++K L HP++I+ Y     +  + +V E A  G++   ++ H +  
Sbjct  71   MDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDL-SRMIKHFKKQ  129

Query  79   ---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF-TP  134
               + E+   + F Q+ +A+   H R ++HRD+K  N+ + A   +K+ D G    F + 
Sbjct  130  KRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK  189

Query  135  GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
                 +  G+P Y +PE      Y+  K DIWSLG +LY +     PF G  +
Sbjct  190  TTAAHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQSPFYGDKM  241


>gi|41688789|sp|Q96J92|WNK4_HUMAN  Serine/threonine-protein kinase WNK4 (Protein kinase with no 
lysine 4) (Protein kinase, lysine-deficient 4)
Length=1243

 Score = 79.7 bits (195),  Expect = 8e-15
 Identities = 94/394 (23%), Positives = 158/394 (40%), Gaps = 79/394 (20%)

Query  20   QLDEENLKKIFREVQIMKMLCHPHIIRLYQ----VMETERMIYLVTEYASGGEIFDHLVA  75
            +L     ++   EV+++K L HP+I+R Y     V+  +  I LVTE  + G +  +L  
Sbjct  209  KLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRR  268

Query  76   HGRMAEKEARRKFKQIVTAVYFCHCR--NIVHRDLKAENLLLDANL-NIKIADFGFSNLF  132
               M  +  +R  +QI+  ++F H R   I+HRDLK +N+ +     ++KI D G + L 
Sbjct  269  FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL-  327

Query  133  TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN---  189
                  K+  G+P + APE++E K YD   VD+++ G+ +  +     P+  S  QN   
Sbjct  328  KRASFAKSVIGTPEFMAPEMYEEK-YD-EAVDVYAFGMCMLEMATSEYPY--SECQNAAQ  383

Query  190  LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLD  249
            +  +V SG+           FH                     + I E + +I   +  D
Sbjct  384  IYRKVTSGR-------KPNSFHK--------------------VKIPEVKEIIEGCIRTD  416

Query  250  PNKRLSMEQICKHK-------------------------WMKLGDA----DPNFDRLIAE  280
             N+R +++ +  H                          W+++ DA     P  ++ I  
Sbjct  417  KNERFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEF  476

Query  281  CQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTL  340
              QL  +       E+V   M  +GL  E   Q +     +  +AI      R K  K  
Sbjct  477  LFQLGRDAA-----EEVAQEMVALGLVCEADYQPVARAVRERVAAIQR---KREKLRKAR  528

Query  341  RLGALPSMPRALAFQAPVNIQPDGTLNLDSDEGE  374
             L ALP  P       P+   P      + +E E
Sbjct  529  ELEALPPEPGPPPATVPMAPGPPSVFPPEPEEPE  562


>gi|13124559|sp|Q13043|STK4_HUMAN  Serine/threonine-protein kinase 4 (STE20-like kinase MST1) (MST-1) 
(Mammalian STE20-like protein kinase 1) (Serine/threonine-protein 
kinase Krs-2)
Length=487

 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 64/274 (23%), Positives = 116/274 (42%), Gaps = 39/274 (14%)

Query  23   EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAE  81
            E +L++I +E+ IM+    PH+++ Y        +++V EY   G + D +    + + E
Sbjct  64   ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTE  123

Query  82   KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLK-T  140
             E     +  +  + + H    +HRD+KA N+LL+   + K+ADFG +   T     + T
Sbjct  124  DEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT  183

Query  141  WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVL-----  195
              G+P + APE+ +   Y+    DIWSLG+    +  G  P+  + +  +RA  +     
Sbjct  184  VIGTPFWMAPEVIQEIGYN-CVADIWSLGITAIEMAEGKPPY--ADIHPMRAIFMIPTNP  240

Query  196  SGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS  255
               FR P   S  +                                ++  LV  P +R +
Sbjct  241  PPTFRKPELWSDNF-----------------------------TDFVKQCLVKSPEQRAT  271

Query  256  MEQICKHKWMKLGDADPNFDRLIAECQQLKEERQ  289
              Q+ +H +++          LI E   +K +RQ
Sbjct  272  ATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQ  305


>gi|50400798|sp|Q9UBE8|NLK_HUMAN  Serine/threonine kinase NLK (Nemo-like kinase) (LAK1 protein)
Length=515

 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 65/277 (23%), Positives = 125/277 (45%), Gaps = 27/277 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-----IYLVTEYA  64
            +VA+K +     +  + K++FRE++++    H +++    +++   +     IY+VTE  
Sbjct  151  RVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELM  210

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA  124
               ++   +V+   ++    +    QI+  + + H   I+HRD+K  NLL+++N  +KI 
Sbjct  211  QS-DLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKIC  269

Query  125  DFGFSNL--FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            DFG + +      + +     +  Y APE+  G  +    +DIWS+G +   L+   + F
Sbjct  270  DFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILF  329

Query  183  DG-STLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCN----VVLNAKDKRLKAGCL----  233
               S +Q L          I   + T     + + C      +L    K+     L    
Sbjct  330  QAQSPIQQLDL--------ITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLS  381

Query  234  --SIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG  268
              +  E  HL+  MLV DP+KR+S +    H ++  G
Sbjct  382  SQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEG  418


>gi|1174630|sp|P42680|TEC_HUMAN  Tyrosine-protein kinase Tec
Length=631

 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 54/192 (28%), Positives = 91/192 (47%), Gaps = 8/192 (4%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KVAIK I +  + EE+      E ++M  L HP +++LY V   ++ IY+VTE+   G +
Sbjct  394  KVAIKAIREGAMCEEDF---IEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCL  450

Query  70   FDHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
             + L    G  +        + +   + +    + +HRDL A N L+     +K++DFG 
Sbjct  451  LNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGM  510

Query  129  SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS  185
            +  F   Q   +     P  +  PE+F    +   K D+WS GV+++ V   G +PF+  
Sbjct  511  ARYFLDDQYTSSSGAKFPVKWCPPEVFNYSRFSS-KSDVWSFGVLMWEVFTEGRMPFEKY  569

Query  186  TLQNLRARVLSG  197
            T   +   V  G
Sbjct  570  TNYEVVTMVTRG  581


>gi|41688799|sp|Q9Y3S1|WNK2_HUMAN  Serine/threonine-protein kinase WNK2 (Protein kinase with no 
lysine 2) (Protein kinase, lysine-deficient 2)
Length=2297

 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 52/171 (30%), Positives = 89/171 (52%), Gaps = 13/171 (7%)

Query  19   TQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET----ERMIYLVTEYASGGEIFDHLV  74
            T+L+ +  K+   E +++K L HP+I+R Y   E+    +R I LVTE  + G +  +L 
Sbjct  232  TKLERQRFKE---EAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLK  288

Query  75   AHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL-NIKIADFGFSNL  131
                M  K  R   +QI+  + F H R   I+HRDLK +N+ +     ++KI D G + L
Sbjct  289  RFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL  348

Query  132  FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
                   K+  G+P + APE++E  E+    VD+++ G+ +  +     P+
Sbjct  349  -KRASFAKSVIGTPEFMAPEMYE--EHYDESVDVYAFGMCMLEMATSEYPY  396


 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 44/179 (24%), Positives = 60/179 (33%), Gaps = 34/179 (18%)

Query  884   FSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQPALMHSESM  943
             FS   A    P D  P     + ++ P +  S   Q LLS   P       PA +   S 
Sbjct  1370  FSAESAQSKQPPDSAPYKDQLSSKEQPSFLAS---QQLLSQAGPSNPPGAPPAPLAPSSP  1426

Query  944   EEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQEL------  997
                          QD  + +T T     S      GGPG P+ L   +  +Q L      
Sbjct  1427  PVTALP-------QDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEA  1479

Query  998   ---------GIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPA  1047
                      G+ P    P AA +++    REP+         P  A E   H+G   PA
Sbjct  1480  PLAVQPLVVGLAPCTPAPEAASTRDASAPREPL---------PPPAPEPSPHSGTPQPA  1529


>gi|6685621|sp|Q9Y6R4|M3K4_HUMAN  Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase 
kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1)
Length=1607

 Score = 79.0 bits (193),  Expect = 1e-14
 Identities = 59/180 (32%), Positives = 91/180 (50%), Gaps = 11/180 (6%)

Query  11    VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
             +A+K I     D + +K+   E++I + + HP+++R + V      +Y+  EY   G + 
Sbjct  1368  MAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE  1427

Query  71    DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-  129
             +  V+   + E   R   KQI  A+   H   IVHRD+K  N+ L ++  IK+ DFG S 
Sbjct  1428  E--VSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSV  1485

Query  130   ----NLFT-PGQLLKTWCGSPPYAAPELFEGK--EYDGPKVDIWSLGVVLYVLVCGALPF  182
                 N  T PG++  T  G+  Y APE+      E  G   DIWSLG V+  +V G  P+
Sbjct  1486  KLKNNAQTMPGEVNST-LGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPW  1544


>gi|125651|sp|P04049|RAF1_HUMAN  RAF proto-oncogene serine/threonine-protein kinase (Raf-1) (C-RAF) 
(cRaf)
Length=648

 Score = 79.0 bits (193),  Expect = 1e-14
 Identities = 60/233 (25%), Positives = 112/233 (48%), Gaps = 25/233 (10%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+KI+       E  +    EV +++   H +I+ L+    T+  + +VT++  G  ++
Sbjct  372  VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLY  430

Query  71   DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             HL V   +    +     +Q    + + H +NI+HRD+K+ N+ L   L +KI DFG +
Sbjct  431  KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA  490

Query  130  NL---FTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFDG  184
             +   ++  Q ++   GS  + APE+   ++ +    + D++S G+VLY L+ G LP+  
Sbjct  491  TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSH  550

Query  185  STLQNLRARVLSGKFRIPFFMSTGY----FHLLGSHCNVVLNAKDKRLKAGCL  233
                      ++ + +I F +  GY       L  +C   +    KRL A C+
Sbjct  551  ----------INNRDQIIFMVGRGYASPDLSKLYKNCPKAM----KRLVADCV  589


>gi|125870|sp|P07947|YES_HUMAN  Proto-oncogene tyrosine-protein kinase Yes (p61-Yes) (c-Yes)
Length=543

 Score = 79.0 bits (193),  Expect = 1e-14
 Identities = 67/212 (31%), Positives = 99/212 (46%), Gaps = 27/212 (12%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            T+    KVAIK +    +  E      +E QIMK L H  ++ LY V+ +E  IY+VTE+
Sbjct  295  TWNGTTKVAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEF  350

Query  64   ASGGEIFDHLVAHGRMAEKEARRKF----------KQIVTAVYFCHCRNIVHRDLKAENL  113
             S G + D L        KE   K+           QI   + +    N +HRDL+A N+
Sbjct  351  MSKGSLLDFL--------KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANI  402

Query  114  LLDANLNIKIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVV  171
            L+  NL  KIADFG + L    +         P  + APE      +   K D+WS G++
Sbjct  403  LVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGIL  461

Query  172  LYVLVC-GALPFDGSTLQNLRARVLSGKFRIP  202
               LV  G +P+ G   + +  +V  G +R+P
Sbjct  462  QTELVTKGRVPYPGMVNREVLEQVERG-YRMP  492


>gi|68067660|sp|P50750|CDK9_HUMAN  Cell division protein kinase 9 (Cyclin-dependent kinase 9) (Serine/threonine-protein 
kinase PITALRE) (C-2K) (Cell division 
cycle 2-like protein kinase 4)
Length=372

 Score = 79.0 bits (193),  Expect = 1e-14
 Identities = 71/279 (25%), Positives = 126/279 (45%), Gaps = 36/279 (12%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM--------IYLVT  61
            KVA+K +      E       RE++I+++L H +++ L ++  T+          IYLV 
Sbjct  44   KVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVF  103

Query  62   EYAS---GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN  118
            ++      G + + LV   +    E +R  + ++  +Y+ H   I+HRD+KA N+L+  +
Sbjct  104  DFCEHDLAGLLSNVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRD  160

Query  119  LNIKIADFGFSNLFT----------PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSL  168
              +K+ADFG +  F+            +++  W     Y  PEL  G+   GP +D+W  
Sbjct  161  GVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW-----YRPPELLLGERDYGPPIDLWGA  215

Query  169  GVVLYVLVCGALPFDGSTLQNLRARV--LSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDK  226
            G ++  +   +    G+T Q+  A +  L G      + +   + L      +V   K K
Sbjct  216  GCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELY-EKLELVKGQKRK  274

Query  227  ---RLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKH  262
               RLKA        + LI  +LVLDP +R+  +    H
Sbjct  275  VKDRLKAYVRDPYALD-LIDKLLVLDPAQRIDSDDALNH  312


>gi|1706450|sp|Q09013|DMPK_HUMAN  Myotonin-protein kinase (Myotonic dystrophy protein kinase) (MDPK) 
(DM-kinase) (DMK) (DMPK) (MT-PK)
Length=639

 Score = 79.0 bits (193),  Expect = 1e-14
 Identities = 57/181 (31%), Positives = 91/181 (50%), Gaps = 10/181 (5%)

Query  12   AIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI++K  + +      FRE + ++       I +L+   + E  +YLV EY  GG++ 
Sbjct  108  AMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLL  167

Query  71   DHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L   G R+  + AR    +IV A+   H    VHRD+K +N+LLD   +I++ADFG  
Sbjct  168  TLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSC  227

Query  130  NLFTPGQLLKTW--CGSPPYAAPELFE------GKEYDGPKVDIWSLGVVLYVLVCGALP  181
                    +++    G+P Y +PE+ +      G    GP+ D W+LGV  Y +  G  P
Sbjct  228  LKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTP  287

Query  182  F  182
            F
Sbjct  288  F  288


>gi|1705485|sp|P51451|BLK_HUMAN  Tyrosine-protein kinase BLK (B lymphocyte kinase) (p55-BLK)
Length=505

 Score = 78.2 bits (191),  Expect = 2e-14
 Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 10/197 (5%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KVAIK + +  +  E       E  +MK L H  ++RLY V+ T+  IY+VTEY + G +
Sbjct  265  KVAIKTLKEGTMSPE---AFLGEANMMKALQHERLVRLYAVV-TKEPIYIVTEYMARGCL  320

Query  70   FDHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
             D L      R++         QI   + +    N +HRDL+A N+L+   L  KIADFG
Sbjct  321  LDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFG  380

Query  128  FSNLFTPGQLLKTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS  185
             + +       +     P  + APE      +   K D+WS GV+L  V+  G +P+ G 
Sbjct  381  LARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFT-IKADVWSFGVLLMEVVTYGRVPYPGM  439

Query  186  TLQNLRARVLSGKFRIP  202
            +   +  R L   +R+P
Sbjct  440  SNPEV-IRNLERGYRMP  455


>gi|66774048|sp|Q14004|CD2L5_HUMAN  Cell division cycle 2-like protein kinase 5 (CDC2-related protein 
kinase 5) (Cholinesterase-related cell division controller)
Length=1512

 Score = 78.2 bits (191),  Expect = 2e-14
 Identities = 74/290 (25%), Positives = 128/290 (44%), Gaps = 50/290 (17%)

Query  16    IDKTQLDEENLK---KIFREVQIMKMLCHPHIIRLYQVMETER----------MIYLVTE  62
             + K +LD E         RE++I++ L H  II + +++  +             YLV E
Sbjct  733   LKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFE  792

Query  63    YASGGEIFDH----LVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD  116
             Y       DH    L+  G     E   +   +Q++  + +CH +N +HRD+K  N+LL+
Sbjct  793   Y------MDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLN  846

Query  117   ANLNIKIADFGFSNLFT-------PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLG  169
                 IK+ADFG + L++         +++  W     Y  PEL  G+E   P +D+WS G
Sbjct  847   NRGQIKLADFGLARLYSSEESRPYTNKVITLW-----YRPPELLLGEERYTPAIDVWSCG  901

Query  170   VVLYVLVCGALPFDGS---TLQNLRARVLSGKFRI--PFFMSTGYFHLLGSHCNVVLNAK  224
              +L  L      F  +       L +R+         P  +   YF+ +           
Sbjct  902   CILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPK-----KQY  956

Query  225   DKRLKAGCLSI-AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPN  273
              ++L+   + I A    L  +ML LDP+KR + EQ  + ++++  D +P+
Sbjct  957   RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR--DVEPS  1004


>gi|41688792|sp|Q9BYP7|WNK3_HUMAN  Serine/threonine-protein kinase WNK3 (Protein kinase with no 
lysine 3) (Protein kinase, lysine-deficient 3)
Length=1743

 Score = 77.8 bits (190),  Expect = 3e-14
 Identities = 65/239 (27%), Positives = 116/239 (48%), Gaps = 33/239 (13%)

Query  19   TQLDEENLKKIFREVQIMKMLCHPHIIRLYQ----VMETERMIYLVTEYASGGEIFDHLV  74
            T+ +++  K+   E +++K L HP+I+R Y     +++ ++ I LVTE  + G +  +L 
Sbjct  184  TKAEQQRFKE---EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK  240

Query  75   AHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL-NIKIADFGFSNL  131
                M  K  R   +QI+  + F H R   I+HRDLK +N+ +     ++KI D G + L
Sbjct  241  RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL  300

Query  132  FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN--  189
                   K+  G+P + APE++E  E+    VD+++ G+ +  +     P+  S  QN  
Sbjct  301  MRT-SFAKSVIGTPEFMAPEMYE--EHYDESVDVYAFGMCMLEMATSEYPY--SECQNAA  355

Query  190  -LRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHL-IRHML  246
             +  +V SG              +  +  N V + + K +  GC+   + E L IR +L
Sbjct  356  QIYRKVTSG--------------IKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLL  400


>gi|41688795|sp|Q9H4A3|WNK1_HUMAN  Serine/threonine-protein kinase WNK1 (Protein kinase with no 
lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient 
protein)
Length=2382

 Score = 77.8 bits (190),  Expect = 3e-14
 Identities = 58/188 (30%), Positives = 96/188 (51%), Gaps = 15/188 (7%)

Query  20   QLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET----ERMIYLVTEYASGGEIFDHLVA  75
            +L +   ++   E +++K L HP+I+R Y   E+    ++ I LVTE  + G +  +L  
Sbjct  256  KLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR  315

Query  76   HGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL-NIKIADFGFSNLF  132
               M  K  R   +QI+  + F H R   I+HRDLK +N+ +     ++KI D G + L 
Sbjct  316  FKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-  374

Query  133  TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN---  189
                  K+  G+P + APE++E K YD   VD+++ G+ +  +     P+  S  QN   
Sbjct  375  KRASFAKSVIGTPEFMAPEMYEEK-YD-ESVDVYAFGMCMLEMATSEYPY--SECQNAAQ  430

Query  190  LRARVLSG  197
            +  RV SG
Sbjct  431  IYRRVTSG  438


>gi|74761996|sp|Q9UL54|TAOK2_HUMAN  Serine/threonine-protein kinase TAO2 (Thousand and one amino 
acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) 
(Kinase from chicken homolog C) (hKFC-C)
Length=1235

 Score = 76.6 bits (187),  Expect = 6e-14
 Identities = 53/165 (32%), Positives = 87/165 (52%), Gaps = 10/165 (6%)

Query  11   VAIKIIDKT-QLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VAIK +  + +   E  + I +EV+ ++ L HP+ I+       E   +LV EY  G   
Sbjct  54   VAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSAS  113

Query  70   FDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
             D L  H + + E E        +  + + H  N++HRD+KA N+LL     +K+ DFG 
Sbjct  114  -DLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGS  172

Query  129  SNLFTPGQLLKTWCGSPPYAAPEL---FEGKEYDGPKVDIWSLGV  170
            +++  P     ++ G+P + APE+    +  +YDG KVD+WSLG+
Sbjct  173  ASIMAPA---NSFVGTPYWMAPEVILAMDEGQYDG-KVDVWSLGI  213


>gi|2499600|sp|Q16539|MK14_HUMAN  Mitogen-activated protein kinase 14 (Mitogen-activated protein 
kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive 
anti-inflammatory drug binding protein) (CSAID-binding 
protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) 
(SAPK2A)
Length=360

 Score = 76.6 bits (187),  Expect = 6e-14
 Identities = 78/321 (24%), Positives = 142/321 (44%), Gaps = 32/321 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEY  63
            +VA+K + +      + K+ +RE++++K + H ++I L  V    R       +YLVT  
Sbjct  49   RVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHL  108

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI  123
               G   +++V   ++ +   +    QI+  + + H  +I+HRDLK  NL ++ +  +KI
Sbjct  109  M--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKI  166

Query  124  ADFGFSNLF---TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL  180
             DFG +        G +   W     Y APE+     +    VDIWS+G ++  L+ G  
Sbjct  167  LDFGLARHTDDEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT  221

Query  181  PFDGSTLQN-----LRARVLSGKFRIPFFMSTGYFHLLGSHCNV-VLNAKDKRLKAGCLS  234
             F G+   +     LR     G   +    S    + + S   +  +N  +  + A  L+
Sbjct  222  LFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLA  281

Query  235  IAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQV----  290
            +     L+  MLVLD +KR++  Q   H +      DP+ + +     Q  E R +    
Sbjct  282  V----DLLEKMLVLDSDKRITAAQALAHAYFAQYH-DPDDEPVADPYDQSFESRDLLIDE  336

Query  291  -DPLNEDVLLAMEDMGLDKEQ  310
               L  D +++     LD+E+
Sbjct  337  WKSLTYDEVISFVPPPLDQEE  357


>gi|37537993|sp|Q9HC98|NEK6_HUMAN  Serine/threonine-protein kinase Nek6 (NimA-related protein kinase 
6) (Protein kinase SID6-1512)
Length=313

 Score = 76.3 bits (186),  Expect = 8e-14
 Identities = 47/172 (27%), Positives = 83/172 (48%), Gaps = 6/172 (3%)

Query  21   LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR--  78
            +D +  +   +E+ ++K L HP+II+       +  + +V E A  G++   +    +  
Sbjct  82   MDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQK  141

Query  79   --MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF-TPG  135
              + E+   + F Q+ +AV   H R ++HRD+K  N+ + A   +K+ D G    F +  
Sbjct  142  RLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSET  201

Query  136  QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
                +  G+P Y +PE      Y+  K DIWSLG +LY +     PF G  +
Sbjct  202  TAAHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQSPFYGDKM  252


>gi|3183518|sp|Q05397|FAK1_HUMAN  Focal adhesion kinase 1 (FADK 1) (pp125FAK) (Protein-tyrosine 
kinase 2)
Length=1052

 Score = 76.3 bits (186),  Expect = 8e-14
 Identities = 56/199 (28%), Positives = 95/199 (47%), Gaps = 8/199 (4%)

Query  8    AAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
            A  VAIK       D    +K  +E   M+   HPHI++L  V+ TE  ++++ E  + G
Sbjct  448  ALAVAIKTCKNCTSDSVR-EKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLG  505

Query  68   EIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF  126
            E+   L       +  +   +  Q+ TA+ +   +  VHRD+ A N+L+ +N  +K+ DF
Sbjct  506  ELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDF  565

Query  127  GFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFD  183
            G S         K   G  P  + APE    + +     D+W  GV ++ +L+ G  PF 
Sbjct  566  GLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSAS-DVWMFGVCMWEILMHGVKPFQ  624

Query  184  GSTLQNLRARVLSGKFRIP  202
            G    ++  R+ +G+ R+P
Sbjct  625  GVKNNDVIGRIENGE-RLP  642


>gi|125358|sp|P09769|FGR_HUMAN  Proto-oncogene tyrosine-protein kinase FGR (P55-FGR) (C-FGR)
Length=529

 Score = 76.3 bits (186),  Expect = 8e-14
 Identities = 58/199 (29%), Positives = 96/199 (48%), Gaps = 10/199 (5%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            T+  + KVA+K +    +     K    E Q+MK+L H  +++LY V+ +E  IY+VTE+
Sbjct  281  TWNGSTKVAVKTLKPGTMSP---KAFLEEAQVMKLLRHDKLVQLYAVV-SEEPIYIVTEF  336

Query  64   ASGGEIFDHLV-AHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
               G + D L    G+ +   +      Q+   + +    N +HRDL+A N+L+   L  
Sbjct  337  MCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLAC  396

Query  122  KIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-G  178
            KIADFG + L    +         P  + APE      +   K D+WS G++L  L+  G
Sbjct  397  KIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFT-IKSDVWSFGILLTELITKG  455

Query  179  ALPFDGSTLQNLRARVLSG  197
             +P+ G   + +  +V  G
Sbjct  456  RIPYPGMNKREVLEQVEQG  474


>gi|2851522|sp|P53778|MK12_HUMAN  Mitogen-activated protein kinase 12 (Extracellular signal-regulated 
kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 
3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase 
p38 gamma)
Length=367

 Score = 76.3 bits (186),  Expect = 8e-14
 Identities = 53/186 (28%), Positives = 90/186 (48%), Gaps = 16/186 (8%)

Query  9    AKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMI------YLVTE  62
            AKVAIK + +    E   K+ +RE++++K + H ++I L  V   +  +      YLV  
Sbjct  51   AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP  110

Query  63   YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK  122
            +   G     L+ H ++ E   +    Q++  + + H   I+HRDLK  NL ++ +  +K
Sbjct  111  FM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELK  168

Query  123  IADFGF---SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA  179
            I DFG    ++    G ++  W     Y APE+          VDIWS+G ++  ++ G 
Sbjct  169  ILDFGLARQADSEMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK  223

Query  180  LPFDGS  185
              F GS
Sbjct  224  TLFKGS  229


>gi|729887|sp|P41240|CSK_HUMAN  Tyrosine-protein kinase CSK (C-SRC kinase) (Protein-tyrosine 
kinase CYL)
Length=450

 Score = 76.3 bits (186),  Expect = 8e-14
 Identities = 58/196 (29%), Positives = 99/196 (50%), Gaps = 19/196 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-IYLVTEYASGGE  68
            KVA+K I     ++   +    E  +M  L H ++++L  V+  E+  +Y+VTEY + G 
Sbjct  218  KVAVKCIK----NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGS  273

Query  69   IFDHLVAHGR-MAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF  126
            + D+L + GR +   +   KF   +  A+ +    N VHRDL A N+L+  +   K++DF
Sbjct  274  LVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDF  333

Query  127  GF----SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALP  181
            G     S+    G+L   W       APE    K++   K D+WS G++L+ +   G +P
Sbjct  334  GLTKEASSTQDTGKLPVKW------TAPEALREKKF-STKSDVWSFGILLWEIYSFGRVP  386

Query  182  FDGSTLQNLRARVLSG  197
            +    L+++  RV  G
Sbjct  387  YPRIPLKDVVPRVEKG  402


>gi|547759|sp|Q06187|BTK_HUMAN  Tyrosine-protein kinase BTK (Bruton's tyrosine kinase) (Agammaglobulinaemia 
tyrosine kinase) (ATK) (B cell progenitor kinase) 
(BPK)
Length=659

 Score = 76.3 bits (186),  Expect = 8e-14
 Identities = 48/191 (25%), Positives = 94/191 (49%), Gaps = 8/191 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK+I +  + E+   +   E ++M  L H  +++LY V   +R I+++TEY + G + 
Sbjct  427  VAIKMIKEGSMSED---EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLL  483

Query  71   DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            ++L     R   ++     K +  A+ +   +  +HRDL A N L++    +K++DFG S
Sbjct  484  NYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS  543

Query  130  NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST  186
                  +   +     P  ++ PE+    ++   K DIW+ GV+++ +   G +P++  T
Sbjct  544  RYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSS-KSDIWAFGVLMWEIYSLGKMPYERFT  602

Query  187  LQNLRARVLSG  197
                   +  G
Sbjct  603  NSETAEHIAQG  613


>gi|78099183|sp|Q9H2K8|TAOK3_HUMAN  Serine/threonine-protein kinase TAO3 (Thousand and one amino 
acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK-inhibitory 
kinase) (Dendritic-cell derived protein kinase) (Cutaneous 
T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen 
HD-CL-09) (Kinase from chicken homolog A) (hKFC-A)
Length=898

 Score = 75.9 bits (185),  Expect = 1e-13
 Identities = 50/151 (33%), Positives = 80/151 (52%), Gaps = 9/151 (5%)

Query  24   ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAEK  82
            E  + I +EV+ ++ L HP+ I        E   +LV EY  G    D L  H + + E 
Sbjct  64   EKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSAS-DLLEVHKKPLQEV  122

Query  83   EARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWC  142
            E        +  + + H   ++HRD+KA N+LL     +K+ADFG +++ +P     ++ 
Sbjct  123  EIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPA---NSFV  179

Query  143  GSPPYAAPEL---FEGKEYDGPKVDIWSLGV  170
            G+P + APE+    +  +YDG KVDIWSLG+
Sbjct  180  GTPYWMAPEVILAMDEGQYDG-KVDIWSLGI  209


>gi|125387|sp|P29320|EPHA3_HUMAN  Ephrin type-A receptor 3 precursor (Tyrosine-protein kinase receptor 
ETK1) (HEK) (HEK4)
Length=983

 Score = 75.5 bits (184),  Expect = 1e-13
 Identities = 59/198 (29%), Positives = 96/198 (48%), Gaps = 9/198 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K    E+  +    E  IM    HP+IIRL  V+   + + +VTEY   G + 
Sbjct  650  VAIKTL-KVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLD  708

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  H  +    +     + I + + +      VHRDL A N+L+++NL  K++DFG S
Sbjct  709  SFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLS  768

Query  130  NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
             +    P     T  G  P  + +PE    +++     D+WS G+VL+ V+  G  P+  
Sbjct  769  RVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSAS-DVWSYGIVLWEVMSYGERPYWE  827

Query  185  STLQNLRARVLSGKFRIP  202
             + Q++   V  G +R+P
Sbjct  828  MSNQDVIKAVDEG-YRLP  844


>gi|543848|sp|P35626|ARBK2_HUMAN  Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (G-protein coupled 
receptor kinase 3)
Length=688

 Score = 74.7 bits (182),  Expect = 2e-13
 Identities = 53/176 (30%), Positives = 91/176 (51%), Gaps = 7/176 (3%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCH----PHIIRLYQVMETERMIYLVTEYASGG  67
            A+K +DK ++  +  + +    +IM  L      P I+ +     T   +  + +  +GG
Sbjct  218  AMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGG  277

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
            ++  HL  HG  +EKE R    +I+  +   H R +V+RDLK  N+LLD + + +I+D G
Sbjct  278  DLHYHLSQHGVFSEKEMRFYATEIILGLEHVHNRFVVYRDLKPANILLDEHGHARISDLG  337

Query  128  FSNLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGALPF  182
             +  F+  +   +  G+  Y APE+ + G  YD    D +SLG +L+ L+ G  PF
Sbjct  338  LACDFSKKKPHAS-VGTHGYMAPEVLQKGTAYDS-SADWFSLGCMLFKLLRGHSPF  391


>gi|1706628|sp|P54756|EPHA5_HUMAN  Ephrin type-A receptor 5 precursor (Tyrosine-protein kinase receptor 
EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine 
kinase HEK7)
Length=1037

 Score = 74.3 bits (181),  Expect = 3e-13
 Identities = 59/198 (29%), Positives = 95/198 (47%), Gaps = 9/198 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K    E+  +    E  IM    HP+II L  V+   + + +VTEY   G + 
Sbjct  704  VAIKTL-KVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLD  762

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  + G+    +     + I   + +      VHRDL A N+L+++NL  K++DFG S
Sbjct  763  TFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLS  822

Query  130  NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDG  184
             +    P     T  G  P  + APE    +++     D+WS G+V++ +V  G  P+  
Sbjct  823  RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSAS-DVWSYGIVMWEVVSYGERPYWE  881

Query  185  STLQNLRARVLSGKFRIP  202
             T Q++   V  G +R+P
Sbjct  882  MTNQDVIKAVEEG-YRLP  898


>gi|74759012|sp|Q7L7X3|TAOK1_HUMAN  Serine/threonine-protein kinase TAO1 (Thousand and one amino 
acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken 
homolog B) (hKFC-B)
Length=1001

 Score = 74.3 bits (181),  Expect = 3e-13
 Identities = 48/151 (31%), Positives = 80/151 (52%), Gaps = 9/151 (5%)

Query  24   ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAEK  82
            E  + I +EV+ ++ + HP+ I        E   +LV EY  G    D L  H + + E 
Sbjct  68   EKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSAS-DLLEVHKKPLQEV  126

Query  83   EARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWC  142
            E        +  + + H   ++HRD+KA N+LL     +K+ADFG +++ +P     ++ 
Sbjct  127  EIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPA---NSFV  183

Query  143  GSPPYAAPEL---FEGKEYDGPKVDIWSLGV  170
            G+P + APE+    +  +YDG KVD+WSLG+
Sbjct  184  GTPYWMAPEVILAMDEGQYDG-KVDVWSLGI  213


>gi|2499633|sp|Q13163|MP2K5_HUMAN  Dual specificity mitogen-activated protein kinase kinase 5 (MAP 
kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5)
Length=438

 Score = 74.3 bits (181),  Expect = 3e-13
 Identities = 49/160 (30%), Positives = 79/160 (49%), Gaps = 7/160 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            +A+K+I    +  E  K+I  E++I+      +II  Y     E  I + TE+  GG   
Sbjct  192  LAVKVI-LLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGS--  248

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
              L  + +M E    R    +V  + +     I+HRD+K  N+L++    +K+ DFG S 
Sbjct  249  --LDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVST  306

Query  131  LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV  170
                  + KT+ G+  Y APE   G++Y G   D+WSLG+
Sbjct  307  QLV-NSIAKTYVGTNAYMAPERISGEQY-GIHSDVWSLGI  344


>gi|71153819|sp|Q16584|M3K11_HUMAN  Mitogen-activated protein kinase kinase kinase 11 (Mixed lineage 
kinase 3) (Src-homology 3 domain-containing proline-rich 
kinase)
Length=847

 Score = 74.3 bits (181),  Expect = 3e-13
 Identities = 53/187 (28%), Positives = 89/187 (47%), Gaps = 14/187 (7%)

Query  27   KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARR  86
            + + +E ++  ML HP+II L  V   E  + LV EYA+GG +    +A  R+       
Sbjct  159  ESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPL-SRALAGRRVPPHVLVN  217

Query  87   KFKQIVTAVYFCHCR---NIVHRDLKAENLLL--------DANLNIKIADFGFSNLFTPG  135
               QI   +++ HC     ++HRDLK+ N+LL          +  +KI DFG +  +   
Sbjct  218  WAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKT  277

Query  136  QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVL  195
              +    G+  + APE+ +   +     D+WS GV+L+ L+ G +P+ G     +   V 
Sbjct  278  TQMSA-AGTYAWMAPEVIKASTFSKGS-DVWSFGVLLWELLTGEVPYRGIDCLAVAYGVA  335

Query  196  SGKFRIP  202
              K  +P
Sbjct  336  VNKLTLP  342


>gi|18202489|sp|Q12852|M3K12_HUMAN  Mitogen-activated protein kinase kinase kinase 12 (Mixed lineage 
kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine 
zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK)
Length=859

 Score = 73.9 bits (180),  Expect = 4e-13
 Identities = 44/151 (29%), Positives = 78/151 (51%), Gaps = 1/151 (0%)

Query  32   EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQI  91
            +++ ++ L HP+II    V        ++ E+ + G++++ L A   +           I
Sbjct  161  DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGI  220

Query  92   VTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPE  151
               + + H   I+HRDLK+ N+L+  +  +KI+DFG S   +      ++ G+  + APE
Sbjct  221  AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE  280

Query  152  LFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            +    E    KVDIWS GVVL+ L+ G +P+
Sbjct  281  VIR-NEPVSEKVDIWSFGVVLWELLTGEIPY  310


>gi|120049|sp|P21802|FGFR2_HUMAN  Fibroblast growth factor receptor 2 precursor (FGFR-2) (Keratinocyte 
growth factor receptor 2) (CD332 antigen)
Length=821

 Score = 73.9 bits (180),  Expect = 4e-13
 Identities = 59/204 (28%), Positives = 101/204 (49%), Gaps = 23/204 (11%)

Query  8    AAKVAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASG  66
            A  VA+K++ K    E++L  +  E+++MKM+  H +II L      +  +Y++ EYAS 
Sbjct  511  AVTVAVKML-KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK  569

Query  67   GEIFDHLVAHGRMAEK---------EARRKFKQIVTAVY-------FCHCRNIVHRDLKA  110
            G + ++L A      +         E +  FK +V+  Y       +   +  +HRDL A
Sbjct  570  GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA  629

Query  111  ENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWS  167
             N+L+  N  +KIADFG + ++       KT  G  P  + APE    + Y   + D+WS
Sbjct  630  RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT-HQSDVWS  688

Query  168  LGVVLY-VLVCGALPFDGSTLQNL  190
             GV+++ +   G  P+ G  ++ L
Sbjct  689  FGVLMWEIFTLGGSPYPGIPVEEL  712


>gi|232066|sp|P27361|MK03_HUMAN  Mitogen-activated protein kinase 3 (Extracellular signal-regulated 
kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP 
kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated 
protein 2 kinase)
Length=379

 Score = 73.6 bits (179),  Expect = 5e-13
 Identities = 65/283 (22%), Positives = 121/283 (42%), Gaps = 44/283 (15%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM-----ETERMIYLVTEYA  64
            +VAIK I   +  +   ++  RE+QI+    H ++I +  ++     E  R +Y+V +  
Sbjct  67   RVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM  125

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA  124
                    L+   +++         QI+  + + H  N++HRDLK  NLL++   ++KI 
Sbjct  126  ETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKIC  183

Query  125  DFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL  180
            DFG + +  P       L  +  +  Y APE+    +     +DIWS+G +L  ++    
Sbjct  184  DFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP  243

Query  181  PFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGS----HCNVVLNAKDKR---------  227
             F G    +    +L                +LGS      N ++N K +          
Sbjct  244  IFPGKHYLDQLNHILG---------------ILGSPSQEDLNCIINMKARNYLQSLPSKT  288

Query  228  ----LKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
                 K    S ++   L+  ML  +PNKR+++E+   H +++
Sbjct  289  KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE  331


>gi|399448|sp|P31152|MK04_HUMAN  Mitogen-activated protein kinase 4 (Extracellular signal-regulated 
kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)
Length=557

 Score = 73.6 bits (179),  Expect = 5e-13
 Identities = 50/192 (26%), Positives = 95/192 (49%), Gaps = 20/192 (10%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE-----------RMIY  58
            KVA+K I  +  D  ++K   RE++I++ L H +I+++Y+V+  +            + Y
Sbjct  45   KVAVKKIALS--DARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAY  102

Query  59   LVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA-  117
            +V EY         L+  G +AE+ A+    Q++  + + H  N++HRDLK  N+ +   
Sbjct  103  IVQEYMETD--LARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTE  160

Query  118  NLNIKIADFGFSNL----FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY  173
            +L +KI DFG + +    ++    L     +  Y +P L          +D+W+ G +L 
Sbjct  161  DLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILA  220

Query  174  VLVCGALPFDGS  185
             ++ G + F G+
Sbjct  221  EMLTGRMLFAGA  232


>gi|29427834|sp|Q8N4C8|MINK1_HUMAN  Misshapen-like kinase 1 (Mitogen-activated protein kinase kinase 
kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK 
kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK 
family kinase MiNK)
Length=1332

 Score = 73.2 bits (178),  Expect = 7e-13
 Identities = 56/186 (30%), Positives = 92/186 (49%), Gaps = 21/186 (11%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETER-------MIYLVTEYA  64
            AIK++D T+ +EE +K+   E+ ++K   H   I  Y     ++        ++LV E+ 
Sbjct  52   AIKVMDVTEDEEEEIKQ---EINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFC  108

Query  65   SGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK  122
              G + D +      A KE    +  ++I+  +   H   ++HRD+K +N+LL  N  +K
Sbjct  109  GAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVK  168

Query  123  IADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE-----YDGPKVDIWSLGVVLYVL  175
            + DFG S     T G+   T+ G+P + APE+    E     YD  + DIWSLG+    +
Sbjct  169  LVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPDATYD-YRSDIWSLGITAIEM  226

Query  176  VCGALP  181
              GA P
Sbjct  227  AEGAPP  232


>gi|120046|sp|P11362|FGFR1_HUMAN  Basic fibroblast growth factor receptor 1 precursor (FGFR-1) 
(bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen)
Length=822

 Score = 73.2 bits (178),  Expect = 7e-13
 Identities = 58/202 (28%), Positives = 101/202 (50%), Gaps = 23/202 (11%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGE  68
            KVA+K++ K+   E++L  +  E+++MKM+  H +II L      +  +Y++ EYAS G 
Sbjct  510  KVAVKML-KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN  568

Query  69   IFDHLVA---------HGRMAEKEARRKFKQIVTAVY-------FCHCRNIVHRDLKAEN  112
            + ++L A         +      E +   K +V+  Y       +   +  +HRDL A N
Sbjct  569  LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN  628

Query  113  LLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLG  169
            +L+  +  +KIADFG + ++       KT  G  P  + APE    + Y   + D+WS G
Sbjct  629  VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT-HQSDVWSFG  687

Query  170  VVLY-VLVCGALPFDGSTLQNL  190
            V+L+ +   G  P+ G  ++ L
Sbjct  688  VLLWEIFTLGGSPYPGVPVEEL  709


>gi|547915|sp|P36507|MP2K2_HUMAN  Dual specificity mitogen-activated protein kinase kinase 2 (MAP 
kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK 
kinase 2) (MEK2)
Length=400

 Score = 72.8 bits (177),  Expect = 9e-13
 Identities = 66/274 (24%), Positives = 119/274 (43%), Gaps = 42/274 (15%)

Query  28   KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRK  87
            +I RE+Q++     P+I+  Y    ++  I +  E+  GG + D ++   +   +E   K
Sbjct  114  QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKEAKRIPEEILGK  172

Query  88   FKQIVTA--VYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLL----KTW  141
                V     Y      I+HRD+K  N+L+++   IK+ DFG S     GQL+     ++
Sbjct  173  VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSF  227

Query  142  CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---DGSTLQNLRAR-VLSG  197
             G+  Y APE  +G  Y   + DIWS+G+ L  L  G  P    D   L+ +  R V+ G
Sbjct  228  VGTRSYMAPERLQGTHY-SVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDG  286

Query  198  KFRIPFFMS--------------------TGYFHLLGSHCNVVLNAKDKRLKAGCLSIAE  237
            +   P  +S                       F LL    + ++N    +L  G  +  +
Sbjct  287  EEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELL----DYIVNEPPPKLPNGVFT-PD  341

Query  238  CEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDAD  271
             +  +   L+ +P +R  ++ +  H ++K  + +
Sbjct  342  FQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVE  375


>gi|21263659|sp|Q8WTQ7|GRK7_HUMAN  G protein-coupled receptor kinase 7 precursor (G protein-coupled 
receptor kinase GRK7)
Length=553

 Score = 72.8 bits (177),  Expect = 9e-13
 Identities = 51/174 (29%), Positives = 87/174 (50%), Gaps = 3/174 (1%)

Query  12   AIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A K +DK +L ++  +K+   E +I++ +  P I+ L    E++  + LV    +GG++ 
Sbjct  218  ACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLK  277

Query  71   DHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
             H+   G      +R  F   QI   +   H   IV+RD+K EN+LLD   N +++D G 
Sbjct  278  FHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGL  337

Query  129  SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            +     G+ +    G+  Y APE+   K      VD +++G  +Y +V G  PF
Sbjct  338  AVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPF  391


>gi|29427817|sp|Q8IVH8|M4K3_HUMAN  Mitogen-activated protein kinase kinase kinase kinase 3 (MAPK/ERK 
kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) 
(Germinal center kinase-related protein kinase) (GLK)
Length=894

 Score = 72.8 bits (177),  Expect = 9e-13
 Identities = 60/246 (24%), Positives = 109/246 (44%), Gaps = 29/246 (11%)

Query  24   ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKE  83
            E+   + +E+ +MK   HP+I+  +        +++  E+  GG + D     G ++E +
Sbjct  53   EDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQ  112

Query  84   ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPG-QLLKTWC  142
                 ++ +  +Y+ H +  +HRD+K  N+LL  N ++K+ADFG S   T      K++ 
Sbjct  113  IAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFI  172

Query  143  GSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALP-FDGSTLQNLRARVLSGKF  199
            G+P + APE+   E K       D+W++G+    L     P FD   L  +RA  L  K 
Sbjct  173  GTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFD---LHPMRALFLMTK-  228

Query  200  RIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQI  259
                                  N +  +LK          H ++  L  +P KR + E++
Sbjct  229  ---------------------SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKL  267

Query  260  CKHKWM  265
             +H ++
Sbjct  268  LQHPFV  273


>gi|68565604|sp|Q96GX5|MASTL_HUMAN  Microtubule-associated serine/threonine-protein kinase-like
Length=879

 Score = 72.4 bits (176),  Expect = 1e-12
 Identities = 36/121 (29%), Positives = 67/121 (55%), Gaps = 1/121 (0%)

Query  12   AIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+K++ K  +  +N+  ++  E   + +   P I+ LY  +++   +YLV EY  GG++ 
Sbjct  60   AVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVK  119

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
              L  +G   E+ A +   ++  A+ + H   I+HRDLK +N+L+    +IK+ DFG S 
Sbjct  120  SLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSK  179

Query  131  L  131
            +
Sbjct  180  V  180


 Score = 46.2 bits (108),  Expect = 9e-05
 Identities = 23/53 (43%), Positives = 32/53 (60%), Gaps = 1/53 (1%)

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVL  195
            G+P Y APEL  G+ + GP VD W+LGV L+  + G  PF+  T Q +   +L
Sbjct  740  GTPDYLAPELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL  791


>gi|1706663|sp|P54762|EPHB1_HUMAN  Ephrin type-B receptor 1 precursor (Tyrosine-protein kinase receptor 
EPH-2) (NET) (HEK6) (ELK)
Length=984

 Score = 72.4 bits (176),  Expect = 1e-12
 Identities = 55/200 (27%), Positives = 94/200 (47%), Gaps = 11/200 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K    E+  +    E  IM    HP+IIRL  V+   R + ++TE+   G + 
Sbjct  648  VAIKTL-KAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD  706

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  + G+    +     + I   + +    N VHRDL A N+L+++NL  K++DFG S
Sbjct  707  SFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLS  766

Query  130  NLFTPGQLLKTWCGS------PPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
                      T+  S        + APE    +++     D+WS G+V++ V+  G  P+
Sbjct  767  RYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSFGERPY  825

Query  183  DGSTLQNLRARVLSGKFRIP  202
               + Q++    +   +R+P
Sbjct  826  WDMSNQDV-INAIEQDYRLP  844


>gi|114152|sp|P25098|ARBK1_HUMAN  Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled 
receptor kinase 2)
Length=689

 Score = 72.4 bits (176),  Expect = 1e-12
 Identities = 51/176 (28%), Positives = 91/176 (51%), Gaps = 7/176 (3%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCH----PHIIRLYQVMETERMIYLVTEYASGG  67
            A+K +DK ++  +  + +    +IM  L      P I+ +     T   +  + +  +GG
Sbjct  218  AMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGG  277

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
            ++  HL  HG  +E + R    +I+  +   H R +V+RDLK  N+LLD + +++I+D G
Sbjct  278  DLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLG  337

Query  128  FSNLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGALPF  182
             +  F+  +   +  G+  Y APE+ + G  YD    D +SLG +L+ L+ G  PF
Sbjct  338  LACDFSKKKPHAS-VGTHGYMAPEVLQKGVAYDS-SADWFSLGCMLFKLLRGHSPF  391


>gi|22653927|sp|O94921|PFTK1_HUMAN  Serine/threonine-protein kinase PFTAIRE-1
Length=469

 Score = 72.4 bits (176),  Expect = 1e-12
 Identities = 64/269 (23%), Positives = 116/269 (43%), Gaps = 26/269 (9%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K+I + Q +E       RE  ++K L H +I+ L+ ++ T+  + LV EY    ++ 
Sbjct  161  VALKVI-RLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHT-DLC  218

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             ++  H G +     +    Q++  + + H R I+HRDLK +NLL+     +K+ADFG +
Sbjct  219  QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLA  278

Query  130  NL-FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG-STL  187
                 P         +  Y  P++  G       +D+W +G +   ++ G   F G   +
Sbjct  279  RAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDI  338

Query  188  QNLRARVL-----------SGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLS-I  235
            Q+   R+             G   +P F    +          + ++K+ R     LS +
Sbjct  339  QDQLERIFLVLGTPNEDTWPGVHSLPHFKPERF---------TLYSSKNLRQAWNKLSYV  389

Query  236  AECEHLIRHMLVLDPNKRLSMEQICKHKW  264
               E L   +L   P  RLS +    H++
Sbjct  390  NHAEDLASKLLQCSPKNRLSAQAALSHEY  418


>gi|28201830|sp|Q96RU7|TRIB3_HUMAN  Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative 
kinase) (p65-interacting inhibitor of NF-kappaB) (SINK)
Length=358

 Score = 72.0 bits (175),  Expect = 2e-12
 Identities = 58/230 (25%), Positives = 95/230 (41%), Gaps = 34/230 (14%)

Query  41   HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC  100
            H H+ R  +V+   +++Y      + G++   + +  R+ E EA   F+Q+ TA+  CH 
Sbjct  117  HKHVARPTEVLAGTQLLYAFFT-RTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQ  175

Query  101  RNIVHRDLKAENLLLDANLNIKIADFGFSN---LFTPGQLLKTWCGSPPYAAPELFEGK-  156
              +V RDLK    +       K+      +   L  P   L      P Y  PE+   + 
Sbjct  176  HGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRA  235

Query  157  EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSH  216
             Y G   D+WSLGV L+ ++ G  PF  S    L  ++  G + +P              
Sbjct  236  SYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALP--------------  281

Query  217  CNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
                         AG  + A C  L+R +L  +P +RL+   I  H W++
Sbjct  282  -------------AGLSAPARC--LVRCLLRREPAERLTATGILLHPWLR  316


>gi|29840818|sp|Q9UKE5|TNIK_HUMAN  TRAF2 and NCK-interacting kinase
Length=1360

 Score = 72.0 bits (175),  Expect = 2e-12
 Identities = 71/268 (26%), Positives = 117/268 (43%), Gaps = 31/268 (11%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETER-------MIYLVTEYA  64
            AIK++D T  +EE +K+   E+ ++K   H   I  Y     ++        ++LV E+ 
Sbjct  52   AIKVMDVTGDEEEEIKQ---EINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFC  108

Query  65   SGGEIFDHL--VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK  122
              G + D +       + E+      ++I+  +   H   ++HRD+K +N+LL  N  +K
Sbjct  109  GAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVK  168

Query  123  IADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE-----YDGPKVDIWSLGVVLYVL  175
            + DFG S     T G+   T+ G+P + APE+    E     YD  K D+WSLG+    +
Sbjct  169  LVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPDATYDF-KSDLWSLGITAIEM  226

Query  176  VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSI  235
              GA P     +  +RA  L  +   P   S  +     S     L     +  A     
Sbjct  227  AEGAPPL--CDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPA-----  279

Query  236  AECEHLIRHMLVLD-PNKRLSMEQICKH  262
               E L++H  + D PN+R    Q+  H
Sbjct  280  --TEQLMKHPFIRDQPNERQVRIQLKDH  305


>gi|400127|sp|P07332|FES_HUMAN  Proto-oncogene tyrosine-protein kinase Fes/Fps (C-Fes)
Length=822

 Score = 71.6 bits (174),  Expect = 2e-12
 Identities = 57/193 (29%), Positives = 87/193 (45%), Gaps = 9/193 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K   +T L  +   K  +E +I+K   HP+I+RL  V   ++ IY+V E   GG+  
Sbjct  587  VAVKSCRET-LPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFL  645

Query  71   DHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L   G R+  K   +        + +   +  +HRDL A N L+     +KI+DFG S
Sbjct  646  TFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMS  705

Query  130  NLFTPGQLLKTWCGS----PPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
                 G    +  GS      + APE      Y   + D+WS G++L+     GA P+  
Sbjct  706  REEADGVYAASG-GSRQVPVKWTAPEALNYGRYSS-ESDVWSFGILLWETFSLGASPYPN  763

Query  185  STLQNLRARVLSG  197
             + Q  R  V  G
Sbjct  764  LSNQQTREFVEKG  776


 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 19/93 (20%), Positives = 45/93 (48%), Gaps = 1/93 (1%)

Query  1214  PVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAE  1273
             P++Q  W  +  +TEGL + + +  E++ +     L    ++ Q+  + Y ++ + L+ E
Sbjct  68    PISQS-WAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQE  126

Query  1274  LQEGARQKLHELQEKLSPLGEEMRDRARAHVDA  1306
             L +   Q + +L+ +   L  +     R + +A
Sbjct  127   LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA  159


>gi|68565548|sp|Q9NYL2|MLTK_HUMAN  Mitogen-activated protein kinase kinase kinase MLT (MLK-like 
mitogen-activated protein triple kinase) (Leucine zipper and 
sterile alpha motif kinase ZAK) (Sterile-alpha motif and leucine 
zipper containing kinase AZK) (Mixed lineage kinase-related 
kinase MRK) (Cervical cancer suppressor gene 4 protein)
Length=800

 Score = 71.6 bits (174),  Expect = 2e-12
 Identities = 51/169 (30%), Positives = 88/169 (52%), Gaps = 13/169 (7%)

Query  24   ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH--GRMAE  81
            + L KI +E +I+ +L H +II+ Y V+       +VTEYAS G ++D++ ++    M  
Sbjct  45   KKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDM  104

Query  82   KEARRKFKQIVTAVYFCHCR---NIVHRDLKAENLLLDANLNIKIADFG---FSNLFTPG  135
                     +   +++ H      ++HRDLK+ N+++ A+  +KI DFG   F N  T  
Sbjct  105  DHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM  164

Query  136  QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
             L+ T+    P+ APE+ +         D +S GVVL+ ++   +PF G
Sbjct  165  SLVGTF----PWMAPEVIQSLPV-SETCDTYSYGVVLWEMLTREVPFKG  208


>gi|1177044|sp|P43403|ZAP70_HUMAN  Tyrosine-protein kinase ZAP-70 (70 kDa zeta-associated protein) 
(Syk-related tyrosine kinase)
Length=619

 Score = 71.2 bits (173),  Expect = 3e-12
 Identities = 59/194 (30%), Positives = 92/194 (47%), Gaps = 9/194 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK++ K   ++ + +++ RE QIM  L +P+I+RL  V + E ++ LV E A GG + 
Sbjct  366  VAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM-LVMEMAGGGPLH  423

Query  71   DHLVA-HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              LV     +          Q+   + +   +N VHRDL A N+LL      KI+DFG S
Sbjct  424  KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS  483

Query  130  NLFTPGQLLKT--WCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
                      T    G  P  + APE    +++   + D+WS GV ++  L  G  P+  
Sbjct  484  KALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-RSDVWSYGVTMWEALSYGQKPYKK  542

Query  185  STLQNLRARVLSGK  198
                 + A +  GK
Sbjct  543  MKGPEVMAFIEQGK  556


>gi|20455241|sp|Q9Y572|RIPK3_HUMAN  Receptor-interacting serine/threonine-protein kinase 3 (RIP-like 
protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Length=518

 Score = 71.2 bits (173),  Expect = 3e-12
 Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 21/180 (11%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET-----ERMIYLVTEYAS  65
            VA+KI+        N K I REV+ M  L +  ++RL  V+E      +    LVT++  
Sbjct  47   VAVKIV--------NSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFME  98

Query  66   GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKI  123
             G +   L +          R  K++V  +++ H +N  ++HRDLK  N+L D  L++K+
Sbjct  99   NGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLPDPELHVKL  158

Query  124  ADFGFSNLFTPGQLLKTWCGSP----PYAAPELFEGKEYDGPKV-DIWSLGVVLYVLVCG  178
            ADFG S  F  G    T  G P     Y APELF           D++S G++++ ++ G
Sbjct  159  ADFGLST-FQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAG  217


>gi|76803654|sp|P29323|EPHB2_HUMAN  Ephrin type-B receptor 2 precursor (Tyrosine-protein kinase receptor 
EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) 
(ERK)
Length=1055

 Score = 71.2 bits (173),  Expect = 3e-12
 Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 11/200 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K+   E+  +    E  IM    HP++I L  V+     + ++TE+   G + 
Sbjct  650  VAIKTL-KSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLD  708

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  + G+    +     + I   + +    N VHRDL A N+L+++NL  K++DFG S
Sbjct  709  SFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLS  768

Query  130  NLFTPGQLLKTWC----GSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
                      T+     G  P  + APE  + +++     D+WS G+V++ V+  G  P+
Sbjct  769  RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPY  827

Query  183  DGSTLQNLRARVLSGKFRIP  202
               T Q++    +   +R+P
Sbjct  828  WDMTNQDV-INAIEQDYRLP  846


>gi|1711371|sp|P54764|EPHA4_HUMAN  Ephrin type-A receptor 4 precursor (Tyrosine-protein kinase receptor 
SEK) (Receptor protein-tyrosine kinase HEK8)
Length=986

 Score = 71.2 bits (173),  Expect = 3e-12
 Identities = 56/198 (28%), Positives = 97/198 (48%), Gaps = 9/198 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK +     D++  +    E  IM    HP+II L  V+   + + ++TEY   G + 
Sbjct  650  VAIKTLKAGYTDKQR-RDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLD  708

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  + GR    +     + I + + +    + VHRDL A N+L+++NL  K++DFG S
Sbjct  709  AFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMS  768

Query  130  NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
             +    P     T  G  P  + APE    +++     D+WS G+V++ V+  G  P+  
Sbjct  769  RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSYGERPYWD  827

Query  185  STLQNLRARVLSGKFRIP  202
             + Q++   +  G +R+P
Sbjct  828  MSNQDVIKAIEEG-YRLP  844


>gi|125333|sp|P29317|EPHA2_HUMAN  Ephrin type-A receptor 2 precursor (Tyrosine-protein kinase receptor 
ECK) (Epithelial cell kinase)
Length=976

 Score = 71.2 bits (173),  Expect = 3e-12
 Identities = 59/208 (28%), Positives = 96/208 (46%), Gaps = 9/208 (4%)

Query  1    KTPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLV  60
            KT + +    VAIK + K    E+       E  IM    H +IIRL  V+   + + ++
Sbjct  633  KTSSGKKEVPVAIKTL-KAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMII  691

Query  61   TEYASGGEIFDHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL  119
            TEY   G +   L    G  +  +     + I   + +    N VHRDL A N+L+++NL
Sbjct  692  TEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNL  751

Query  120  NIKIADFGFSNLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-V  174
              K++DFG S +    P     T  G  P  + APE    +++     D+WS G+V++ V
Sbjct  752  VCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSAS-DVWSFGIVMWEV  810

Query  175  LVCGALPFDGSTLQNLRARVLSGKFRIP  202
            +  G  P+   +   +   +  G FR+P
Sbjct  811  MTYGERPYWELSNHEVMKAINDG-FRLP  837


>gi|74762569|sp|Q8NFD2|ANKK1_HUMAN  Ankyrin repeat and protein kinase domain-containing protein 1 
(Protein kinase PKK2) (X-kinase) (SgK288)
Length=765

 Score = 71.2 bits (173),  Expect = 3e-12
 Identities = 50/177 (28%), Positives = 86/177 (48%), Gaps = 11/177 (6%)

Query  29   IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKF  88
            +  E   MK +   HI+ +Y V +  + + +V E+ + G +   L  H  +  K   R  
Sbjct  68   LIEEAAKMKKIKFQHIVSIYGVCK--QPLGIVMEFMANGSLEKVLSTHS-LCWKLRFRII  124

Query  89   KQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLK-----TW  141
             +   A+ F H     ++H DLK  N+LLD+N+++KI+DFG S        ++       
Sbjct  125  HETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSAL  184

Query  142  CGSPPYAAPELF-EGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSG  197
             G   Y  PE+F E  +  GPK D++S  +V++ L+    P+ G  +  +  RV +G
Sbjct  185  RGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAG  241


>gi|2499596|sp|Q16659|MK06_HUMAN  Mitogen-activated protein kinase 6 (Extracellular signal-regulated 
kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)
Length=721

 Score = 70.9 bits (172),  Expect = 4e-12
 Identities = 50/200 (25%), Positives = 94/200 (47%), Gaps = 33/200 (16%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE--------------R  55
            +VAIK I  T  D +++K   RE++I++ L H +I+++++++                  
Sbjct  45   RVAIKKIVLT--DPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELN  102

Query  56   MIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL  115
             +Y+V EY        +++  G + E+ AR    Q++  + + H  N++HRDLK  NL +
Sbjct  103  SVYIVQEYMETD--LANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI  160

Query  116  DA-NLNIKIADFGFSNLFTPGQ---------LLKTWCGSPPYAAPELFEGKEYDGPKVDI  165
            +  +L +KI DFG + +  P           L+  W     Y +P L          +D+
Sbjct  161  NTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKW-----YRSPRLLLSPNNYTKAIDM  215

Query  166  WSLGVVLYVLVCGALPFDGS  185
            W+ G +   ++ G   F G+
Sbjct  216  WAAGCIFAEMLTGKTLFAGA  235


>gi|68846922|sp|Q15375|EPHA7_HUMAN  Ephrin type-A receptor 7 precursor (Tyrosine-protein kinase receptor 
EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine 
kinase HEK11)
Length=998

 Score = 70.9 bits (172),  Expect = 4e-12
 Identities = 54/198 (27%), Positives = 96/198 (48%), Gaps = 9/198 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K    E+  +    E  IM    HP+++ L  V+   + + +V E+   G + 
Sbjct  662  VAIKTL-KVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALD  720

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  H G+    +     + I   + +      VHRDL A N+L+++NL  K++DFG S
Sbjct  721  AFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLS  780

Query  130  NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
             +    P  +  T  G  P  + APE  + +++     D+WS G+V++ V+  G  P+  
Sbjct  781  RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPYWD  839

Query  185  STLQNLRARVLSGKFRIP  202
             + Q++   +  G +R+P
Sbjct  840  MSNQDVIKAIEEG-YRLP  856


>gi|464971|sp|P33981|TTK_HUMAN  Dual specificity protein kinase TTK (Phosphotyrosine picked threonine-protein 
kinase) (PYT)
Length=841

 Score = 70.5 bits (171),  Expect = 5e-12
 Identities = 54/186 (29%), Positives = 83/186 (44%), Gaps = 17/186 (9%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCH--PHIIRLYQVMETERMIYLVTEYASGGEI  69
            AIK ++  + D + L     E+  +  L      IIRLY    T++ IY+V E     ++
Sbjct  535  AIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDL  593

Query  70   FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
               L     +   E +  +K ++ AV+  H   IVH DLK  N L+   + +K+ DFG +
Sbjct  594  NSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-LKLIDFGIA  652

Query  130  NLFTPGQ---LLKTWCGSPPYAAPELFE----------GKEYDGPKVDIWSLGVVLYVLV  176
            N   P     +  +  G+  Y  PE  +           K    PK D+WSLG +LY + 
Sbjct  653  NQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMT  712

Query  177  CGALPF  182
             G  PF
Sbjct  713  YGKTPF  718


>gi|1705722|sp|P50613|CDK7_HUMAN  Cell division protein kinase 7 (CDK-activating kinase) (CAK) 
(TFIIH basal transcription factor complex kinase subunit) (39 
kDa protein kinase) (P39 Mo15) (STK1) (CAK1)
Length=346

 Score = 70.5 bits (171),  Expect = 5e-12
 Identities = 51/176 (28%), Positives = 87/176 (49%), Gaps = 5/176 (2%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY  63
            T Q  A   IK+  +++  +   +   RE+++++ L HP+II L      +  I LV ++
Sbjct  34   TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDF  93

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVT--AVYFCHCRNIVHRDLKAENLLLDANLNI  121
                   + ++    +    +  K   ++T   + + H   I+HRDLK  NLLLD N  +
Sbjct  94   METD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVL  151

Query  122  KIADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
            K+ADFG +  F +P +       +  Y APEL  G    G  VD+W++G +L  L+
Sbjct  152  KLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL  207


>gi|12643557|sp|O43318|M3K7_HUMAN  Mitogen-activated protein kinase kinase kinase 7 (Transforming 
growth factor-beta-activated kinase 1) (TGF-beta-activated 
kinase 1)
Length=606

 Score = 70.5 bits (171),  Expect = 5e-12
 Identities = 61/186 (32%), Positives = 94/186 (50%), Gaps = 19/186 (10%)

Query  9    AKVAIKIIDKTQLDEENLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
            AK   K +   Q++ E+ +K F  E++ +  + HP+I++LY        + LV EYA GG
Sbjct  53   AKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGG  110

Query  68   EIFDHLVAHGR-----MAEKEARRKFKQIVTAVYFCHC---RNIVHRDLKAENLLLDANL  119
             +++  V HG           A     Q    V + H    + ++HRDLK  NLLL A  
Sbjct  111  SLYN--VLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGG  168

Query  120  NI-KIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC  177
             + KI DFG + ++ T     K   GS  + APE+FEG  Y   K D++S G++L+ ++ 
Sbjct  169  TVLKICDFGTACDIQTHMTNNK---GSAAWMAPEVFEGSNY-SEKCDVFSWGIILWEVIT  224

Query  178  GALPFD  183
               PFD
Sbjct  225  RRKPFD  230


>gi|46577075|sp|Q8NEV4|MYO3A_HUMAN  Myosin IIIA
Length=1616

 Score = 70.5 bits (171),  Expect = 5e-12
 Identities = 75/273 (27%), Positives = 116/273 (42%), Gaps = 48/273 (17%)

Query  10   KVAIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMI-----YLVTE  62
            K A+KI+D    +DEE    I  E  I+K L  HP+++R Y +   +  +     +LV E
Sbjct  46   KAAVKILDPIHDIDEE----IEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLE  101

Query  63   YASGGEIFD----HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN  118
              SGG + D     L    RM+E        + +  +   H    +HRD+K  N+LL   
Sbjct  102  LCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTE  161

Query  119  LNIKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKE-----YDGPKVDIWSLGVVL  172
              +K+ DFG S  L +      T  G+P + APE+   ++     YD  + D WSLG+  
Sbjct  162  GGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDA-RCDTWSLGITA  220

Query  173  YVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGC  232
              L  G  P   + L  +RA      F+IP                        +L+   
Sbjct  221  IELGDGDPPL--ADLHPMRA-----LFKIP-------------------RNPPPKLRQPE  254

Query  233  LSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM  265
            L  AE    I   L  D  KR ++ ++ +HK++
Sbjct  255  LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI  287


>gi|47117832|sp|P21709|EPHA1_HUMAN  Ephrin type-A receptor 1 precursor (Tyrosine-protein kinase receptor 
EPH)
Length=976

 Score = 70.5 bits (171),  Expect = 5e-12
 Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 7/177 (3%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL-VAHGRMAEKEARRKFK  89
            RE  IM    HPHI+ L  V+   + I ++TE+   G +   L     ++   +     +
Sbjct  672  REATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQ  731

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTP-GQLLKTWCGSPP--  146
             I + + +    N VHRDL A N+L++ NL  K++DFG + L        +T  G  P  
Sbjct  732  GIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIR  791

Query  147  YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRIP  202
            + APE    + +     D+WS G+V++ VL  G  P+   + Q +   +  G +R+P
Sbjct  792  WTAPEAIAHRIFTTAS-DVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDG-YRLP  846


>gi|6685617|sp|Q99683|M3K5_HUMAN  Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase 
kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating 
kinase 1) (ASK-1)
Length=1374

 Score = 70.1 bits (170),  Expect = 6e-12
 Identities = 53/179 (29%), Positives = 85/179 (47%), Gaps = 6/179 (3%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +V I I +  + D    + +  E+ + K L H +I++          I +  E   GG +
Sbjct  703  QVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSL  762

Query  70   FDHLVAH-GRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI-KIAD  125
               L +  G + + E    F  KQI+  + + H   IVHRD+K +N+L++    + KI+D
Sbjct  763  SALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISD  822

Query  126  FGFS-NLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            FG S  L       +T+ G+  Y APE+ + G    G   DIWSLG  +  +  G  PF
Sbjct  823  FGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF  881


>gi|6166188|sp|P32298|GRK4_HUMAN  G protein-coupled receptor kinase 4 (G protein-coupled receptor 
kinase GRK4) (ITI1)
Length=578

 Score = 69.7 bits (169),  Expect = 8e-12
 Identities = 48/171 (28%), Positives = 83/171 (48%), Gaps = 9/171 (5%)

Query  20   QLDEENLKK------IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL  73
            +L ++ +KK         E +I++ +    ++ L    ET+  + LV    +GG++  H+
Sbjct  217  KLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHI  276

Query  74   VAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL  131
               G     E R  F   ++   +       IV+RDLK EN+LLD   +I+I+D G +  
Sbjct  277  YNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE  336

Query  132  FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
               GQ ++   G+  Y APE+   ++Y     D W LG ++Y ++ G  PF
Sbjct  337  IPEGQRVRGRVGTVGYMAPEVVNNEKYTF-SPDWWGLGCLIYEMIQGHSPF  386


>gi|2499660|sp|Q15569|TESK1_HUMAN  Dual specificity testis-specific protein kinase 1 (Testicular 
protein kinase 1)
Length=626

 Score = 69.3 bits (168),  Expect = 1e-11
 Identities = 46/160 (28%), Positives = 78/160 (48%), Gaps = 9/160 (5%)

Query  25   NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEA  84
            N     REVQ+M  L HP+I+R   V   +  ++ +TEY +GG +   L +   ++    
Sbjct  93   NRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVR  152

Query  85   RRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKIADFGFSN---LFTPGQLL  138
                  I   + + H + + HRDL ++N L+   D      + DFG +    ++  G   
Sbjct  153  LHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARK  212

Query  139  KTWC--GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
            +     GSP + APE+  G+ YD  K D+++ G+VL  L+
Sbjct  213  EPLAVVGSPYWMAPEVLRGELYD-EKADVFAFGIVLCELI  251


>gi|14548079|sp|Q14164|IKKE_HUMAN  Inhibitor of nuclear factor kappa-B kinase epsilon subunit (I 
kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK-E) (Inducible 
I kappa-B kinase) (IKK-i)
Length=716

 Score = 69.3 bits (168),  Expect = 1e-11
 Identities = 52/188 (27%), Positives = 87/188 (46%), Gaps = 17/188 (9%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYASGGE  68
            VA+K+ + T        ++ RE ++++ L H +I++L+ V ET   R   LV EY S G 
Sbjct  35   VAVKVFNTTSYLRPREVQV-REFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGS  93

Query  69   IFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNI  121
            +   L +      + E E     + +V  +       IVHRD+K  N++     +     
Sbjct  94   LLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIY  153

Query  122  KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK-------VDIWSLGVVLYV  174
            K+ DFG +      +   +  G+  Y  P+++E      P+       VD+WS+GV LY 
Sbjct  154  KLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYH  213

Query  175  LVCGALPF  182
               G+LPF
Sbjct  214  AATGSLPF  221


>gi|45593475|sp|Q12851|M4K2_HUMAN  Mitogen-activated protein kinase kinase kinase kinase 2 (MAPK/ERK 
kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) 
(Germinal center kinase) (GC kinase) (Rab8-interacting protein) 
(B lymphocyte serine/threonine-protein kinase)
Length=819

 Score = 68.9 bits (167),  Expect = 1e-11
 Identities = 50/191 (26%), Positives = 95/191 (49%), Gaps = 9/191 (4%)

Query  12   AIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            A+KI+   +LD  +++  + +E+ I++   HP+++           +++  E+  GG + 
Sbjct  42   AVKIV---KLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQ  98

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            +   A G + E++     ++ +  ++  H +  +HRD+K  NLLL    ++K+ADFG S 
Sbjct  99   EIYHATGPLEERQIAYVCRERLKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSG  158

Query  131  LFTPG-QLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL  187
              T      +++ G+P + APE+   E K       D+W+LG+    L  G L      L
Sbjct  159  ELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIEL--GELQPPLFHL  216

Query  188  QNLRARVLSGK  198
              +RA +L  K
Sbjct  217  HPMRALMLMSK  227


>gi|30316147|sp|Q9Y4K4|M4K5_HUMAN  Mitogen-activated protein kinase kinase kinase kinase 5 (MAPK/ERK 
kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) 
(Kinase homologous to SPS1/STE20) (KHS)
Length=846

 Score = 68.6 bits (166),  Expect = 2e-11
 Identities = 64/271 (23%), Positives = 120/271 (44%), Gaps = 33/271 (12%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD  71
            A+KII     D+ +L  I +E+ ++K   H +I+  +    +   +++  EY  GG + D
Sbjct  47   AVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQD  104

Query  72   HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNL  131
                 G ++E +     ++ +  + + H +  +HRD+K  N+LL  + ++K+ADFG +  
Sbjct  105  IYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAK  164

Query  132  FTPG-QLLKTWCGSPPYAAPELFEGKEYDG--PKVDIWSLGVVLYVLVCGALPFDGSTLQ  188
             T      K++ G+P + APE+   ++  G     DIW++G+    L  G L      L 
Sbjct  165  ITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIEL--GELQPPMFDLH  222

Query  189  NLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVL  248
             +RA  L  K                       N +  +LK      +   + ++  L  
Sbjct  223  PMRALFLMSK----------------------SNFQPPKLKDKTKWSSTFHNFVKIALTK  260

Query  249  DPNKRLSMEQICKHKWMKLGDADPNFDRLIA  279
            +P KR + E++  H ++    A P   R +A
Sbjct  261  NPKKRPTAERLLTHTFV----AQPGLSRALA  287


>gi|119554|sp|P28482|MK01_HUMAN  Mitogen-activated protein kinase 1 (Extracellular signal-regulated 
kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) 
(MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)
Length=360

 Score = 68.6 bits (166),  Expect = 2e-11
 Identities = 75/318 (23%), Positives = 136/318 (42%), Gaps = 53/318 (16%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM-----ETERMIYLVTEYA  64
            +VAIK I   +  +   ++  RE++I+    H +II +  ++     E  + +Y+V +  
Sbjct  50   RVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLM  108

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA  124
                    L+    ++         QI+  + + H  N++HRDLK  NLLL+   ++KI 
Sbjct  109  ETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKIC  166

Query  125  DFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL  180
            DFG + +  P       L  +  +  Y APE+    +     +DIWS+G +L  ++    
Sbjct  167  DFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP  226

Query  181  PFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGS----HCNVVLNAKDKRLKAGCLSI-  235
             F G    +    +L                +LGS      N ++N K +      LS+ 
Sbjct  227  IFPGKHYLDQLNHILG---------------ILGSPSQEDLNCIINLKARNY---LLSLP  268

Query  236  ---------------AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAE  280
                           ++   L+  ML  +P+KR+ +EQ   H +++    DP+ D  IAE
Sbjct  269  HKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE-QYYDPS-DEPIAE  326

Query  281  CQQLKEERQVDPLNEDVL  298
                K + ++D L ++ L
Sbjct  327  A-PFKFDMELDDLPKEKL  343


>gi|17375734|sp|O14976|GAK_HUMAN  Cyclin G-associated kinase
Length=1311

 Score = 68.6 bits (166),  Expect = 2e-11
 Identities = 76/258 (29%), Positives = 114/258 (44%), Gaps = 50/258 (19%)

Query  22   DEENLKKIFREVQIMKMLC-HPHIIRLYQVMET--------ERMIYLVTEYASGG--EIF  70
            +EE  + I +EV  MK L  HP+I++               +    L+TE   G   E  
Sbjct  75   EEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFL  134

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKIADFGF  128
              + + G ++     + F Q   AV   H +   I+HRDLK ENLLL     IK+ DFG 
Sbjct  135  KKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGS  194

Query  129  SNLFT--PGQLLKTWCG--------------SPPYAAPELFE--GKEYDGPKVDIWSLGV  170
            +   +  P     +W                +P Y  PE+ +       G K DIW+LG 
Sbjct  195  ATTISHYPDY---SWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGC  251

Query  171  VLYVLVCGALPF-DGSTLQNLRARVLSGKFRIPFFMSTGY--FHLLGSHCNVVLNAKDKR  227
            +LY+L     PF DG+ L     R+++GK+ IP    T Y  FH L     + +N +++ 
Sbjct  252  ILYLLCFRQHPFEDGAKL-----RIVNGKYSIPPH-DTQYTVFHSL-IRAMLQVNPEER-  303

Query  228  LKAGCLSIAECEHLIRHM  245
                 LSIAE  H ++ +
Sbjct  304  -----LSIAEVVHQLQEI  316


>gi|29427585|sp|O95819|M4K4_HUMAN  Mitogen-activated protein kinase kinase kinase kinase 4 (MAPK/ERK 
kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) 
(HPK/GCK-like kinase HGK) (Nck-interacting kinase)
Length=1239

 Score = 68.6 bits (166),  Expect = 2e-11
 Identities = 55/187 (29%), Positives = 92/187 (49%), Gaps = 23/187 (12%)

Query  12   AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETER-------MIYLVTEYA  64
            AIK++D T+ +EE +K    E+ ++K   H   I  Y     ++        ++LV E+ 
Sbjct  52   AIKVMDVTEDEEEEIKL---EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFC  108

Query  65   SGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
              G I D LV + +   + E       ++I+  +   H  +++HRD+K +N+LL  N  +
Sbjct  109  GAGSITD-LVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEV  167

Query  122  KIADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE-----YDGPKVDIWSLGVVLYV  174
            K+ DFG S     T G+   T+ G+P + APE+    E     YD  + D+WS G+    
Sbjct  168  KLVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPDATYD-YRSDLWSCGITAIE  225

Query  175  LVCGALP  181
            +  GA P
Sbjct  226  MAEGAPP  232


>gi|56405328|sp|P29597|TYK2_HUMAN  Non-receptor tyrosine-protein kinase TYK2
Length=1187

 Score = 68.2 bits (165),  Expect = 2e-11
 Identities = 52/153 (33%), Positives = 78/153 (50%), Gaps = 10/153 (6%)

Query  31    REVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKF  88
             +E+ I++ L H HII+     E   E+ + LV EY   G + D+L  H  +   +     
Sbjct  946   QEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFA  1004

Query  89    KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ---LLKTWCGSP  145
             +QI   + + H ++ +HRDL A N+LLD +  +KI DFG +     G     ++    SP
Sbjct  1005  QQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP  1064

Query  146   PY-AAPE-LFEGKEYDGPKVDIWSLGVVLYVLV  176
              +  APE L E K Y     D+WS GV LY L+
Sbjct  1065  VFWYAPECLKEYKFYYAS--DVWSFGVTLYELL  1095


 Score = 37.0 bits (84),  Expect = 0.056
 Identities = 46/184 (25%), Positives = 74/184 (40%), Gaps = 19/184 (10%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +V +K++D +  D       +    +M  + H H+  ++ V        +VTEY   G +
Sbjct  638  RVVLKVLDPSHHDIA--LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPL  695

Query  70   FDHLV---AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF  126
               L     H  MA K    +  Q+ +A+ +   +N+VH ++   N+LL A L +     
Sbjct  696  DVWLRRERGHVPMAWKMVVAQ--QLASALSYLENKNLVHGNVCGRNILL-ARLGLAEGTS  752

Query  127  GFSNLFTPGQLLKTWCGSP-----PYAAPELFEGKEYD-GPKVDIWSLGVVLYVLVCGAL  180
             F  L  PG  L            P+ APE   G        +D W  G  L + +C   
Sbjct  753  PFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATL-LEIC---  808

Query  181  PFDG  184
             FDG
Sbjct  809  -FDG  811


>gi|48428273|sp|Q9UPZ9|ICK_HUMAN  Serine/threonine-protein kinase ICK (Intestinal cell kinase) 
(hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) 
(LCK2)
Length=632

 Score = 68.2 bits (165),  Expect = 2e-11
 Identities = 68/254 (26%), Positives = 108/254 (42%), Gaps = 31/254 (12%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK-  89
            REV+ +K L H ++++L +V+     +Y + EY     ++  +    ++  + A R    
Sbjct  49   REVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKEN-LYQLIKERNKLFPESAIRNIMY  107

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAA  149
            QI+  + F H     HRDLK ENLL      +KIADFG +           +  +  Y A
Sbjct  108  QILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRA  167

Query  150  PE-LFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMST-  207
            PE L     Y  P +D+W++G ++  +      F G       A  +   F+I   + T 
Sbjct  168  PEVLLRSTNYSSP-IDVWAVGCIMAEVYTLRPLFPG-------ASEIDTIFKICQVLGTP  219

Query  208  -------GYFHLLGSHCN------VVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRL  254
                   GY   L S  N      V  N K     A     +E   L+R ML  DP KR 
Sbjct  220  KKTDWPEGY--QLSSAMNFRWPQCVPNNLKTLIPNAS----SEAVQLLRDMLQWDPKKRP  273

Query  255  SMEQICKHKWMKLG  268
            +  Q  ++ + ++G
Sbjct  274  TASQALRYPYFQVG  287


>gi|12644292|sp|P49840|GSK3A_HUMAN  Glycogen synthase kinase-3 alpha (GSK-3 alpha)
Length=483

 Score = 68.2 bits (165),  Expect = 2e-11
 Identities = 81/292 (27%), Positives = 123/292 (42%), Gaps = 33/292 (11%)

Query  18   KTQLDEENLKKIFREVQIMKMLCHPHIIRL----YQVMETERMIYL--VTEYASGGEIFD  71
            K  L ++  K   RE+QIM+ L H +I+RL    Y   E +  +YL  V EY    E   
Sbjct  148  KKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVP--ETVY  203

Query  72   HLVAHGRMAEKE-----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI-KIAD  125
             +  H   A+        +    Q+  ++ + H + + HRD+K +NLL+D +  + K+ D
Sbjct  204  RVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCD  263

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG-  184
            FG +     G+   ++  S  Y APEL  G       +D+WS G VL  L+ G   F G 
Sbjct  264  FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD  323

Query  185  STLQNL--RARVLSGKFRIPF-FMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHL  241
            S +  L    +VL    R     M+  Y              K  + +    +IA C  L
Sbjct  324  SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSL  383

Query  242  IRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPL  293
            + +     P+ RLS  + C H +         FD L     QL   R + PL
Sbjct  384  LEY----TPSSRLSPLEACAHSF---------FDELRCLGTQLPNNRPLPPL  422


>gi|13432166|sp|P20794|MAK_HUMAN  Serine/threonine-protein kinase MAK (Male germ cell-associated 
kinase)
Length=623

 Score = 67.8 bits (164),  Expect = 3e-11
 Identities = 69/254 (27%), Positives = 107/254 (42%), Gaps = 31/254 (12%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRM-AEKEARRKFK  89
            REV+ +K L H ++I+L +V+     +Y + EY     ++  +    ++  E   R    
Sbjct  49   REVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKEN-LYQLMKDRNKLFPESVIRNIMY  107

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAA  149
            QI+  + F H     HRD+K ENLL      +KIADFG +           +  +  Y A
Sbjct  108  QILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRA  167

Query  150  PE-LFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMST-  207
            PE L     Y  P +D+W++G ++  L      F G++        +   F+I   + T 
Sbjct  168  PEVLLRSSVYSSP-IDVWAVGSIMAELYMLRPLFPGTS-------EVDEIFKICQVLGTP  219

Query  208  -------GYFHLLGSHCN------VVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRL  254
                   GY   L S  N      V +N K     A      E   L+  ML  DP KR 
Sbjct  220  KKSDWPEGY--QLASSMNFRFPQCVPINLKTLIPNAS----NEAIQLMTEMLNWDPKKRP  273

Query  255  SMEQICKHKWMKLG  268
            +  Q  KH + ++G
Sbjct  274  TASQALKHPYFQVG  287


>gi|76803655|sp|P54753|EPHB3_HUMAN  Ephrin type-B receptor 3 precursor (Tyrosine-protein kinase receptor 
HEK-2)
Length=998

 Score = 67.8 bits (164),  Expect = 3e-11
 Identities = 54/200 (27%), Positives = 92/200 (46%), Gaps = 11/200 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K    E   +    E  IM    HP+IIRL  V+   R + ++TE+     + 
Sbjct  662  VAIKTL-KVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALD  720

Query  71   DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L +  G+    +     + I   + +    N VHRDL A N+L+++NL  K++DFG S
Sbjct  721  SFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLS  780

Query  130  NLFTPGQLLKTWCGS------PPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
                      T+  S        + APE    +++     D+WS G+V++ V+  G  P+
Sbjct  781  RFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSYGERPY  839

Query  183  DGSTLQNLRARVLSGKFRIP  202
               + Q++    +   +R+P
Sbjct  840  WDMSNQDV-INAVEQDYRLP  858


>gi|2499603|sp|Q15759|MK11_HUMAN  Mitogen-activated protein kinase 11 (Mitogen-activated protein 
kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated 
protein kinase 2)
Length=372

 Score = 67.8 bits (164),  Expect = 3e-11
 Identities = 74/331 (22%), Positives = 139/331 (41%), Gaps = 47/331 (14%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQV------METERMIYLVTEY  63
            KVA+K + +      + ++ +RE++++K L H ++I L  V      +E    +YLVT  
Sbjct  49   KVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTL  108

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFK--------QIVTAVYFCHCRNIVHRDLKAENLLL  115
               G   +++V     A + AR            Q++  + + H   I+HRDLK  N+ +
Sbjct  109  M--GADLNNIVKCQAGAHQGARLALDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV  166

Query  116  DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
            + +  ++I DFG +      + +  +  +  Y APE+     +    VDIWS+G ++  L
Sbjct  167  NEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAEL  224

Query  176  VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLL----GSHCNVVLNAKDKRLKAG  231
            + G   F GS   +   R++         + T    +L      H    + +     +  
Sbjct  225  LQGKALFPGSDYIDQLKRIME-------VVGTPSPEVLAKISSEHARTYIQSLPPMPQKD  277

Query  232  CLSIAECEH-----LIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE  286
              SI    +     L+  MLVLD ++R+S  +   H +              ++    ++
Sbjct  278  LSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY-------------FSQYHDPED  324

Query  287  ERQVDPLNEDVLLAMEDMGLDKEQTLQSLRS  317
            E + +P +E V      +   KE T Q + S
Sbjct  325  EPEAEPYDESVEAKERTLEEWKELTYQEVLS  355


>gi|1345718|sp|P49336|CDK8_HUMAN  Cell division protein kinase 8 (Protein kinase K35)
Length=464

 Score = 67.8 bits (164),  Expect = 3e-11
 Identities = 70/296 (23%), Positives = 125/296 (42%), Gaps = 54/296 (18%)

Query  31   REVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYASGGEIFDHLVAHGRMAEKE-----  83
            RE+ +++ L HP++I L +V     +R ++L+ +YA       H++   R ++       
Sbjct  65   REIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHD--LWHIIKFHRASKANKKPVQ  122

Query  84   -----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTP  134
                  +    QI+  +++ H   ++HRDLK  N+L+         +KIAD GF+ LF  
Sbjct  123  LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF--  180

Query  135  GQLLKTWCGSPP------YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF-----D  183
               LK      P      Y APEL  G  +    +DIW++G +   L+     F     D
Sbjct  181  NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED  240

Query  184  GSTLQNLRARVLSGKFRIPFF-----------------MSTGYFHLLGSHCNVVLNAKDK  226
              T        L   F +  F                 +   +     ++C+++   +  
Sbjct  241  IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH  300

Query  227  RLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQ  282
            ++K      ++  HL++ +L +DP KR++ EQ  +  +  L D  P  D + A CQ
Sbjct  301  KVKPD----SKAFHLLQKLLTMDPIKRITSEQAMQDPYF-LEDPLPTSD-VFAGCQ  350


>gi|20455502|sp|P49841|GSK3B_HUMAN  Glycogen synthase kinase-3 beta (GSK-3 beta)
Length=420

 Score = 67.8 bits (164),  Expect = 3e-11
 Identities = 56/181 (30%), Positives = 86/181 (47%), Gaps = 16/181 (8%)

Query  18   KTQLDEENLKKIFREVQIMKMLCHPHIIRL----YQVMETERMIYL--VTEYASGGEIFD  71
            K  L ++  K   RE+QIM+ L H +I+RL    Y   E +  +YL  V +Y    E   
Sbjct  85   KKVLQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVY  140

Query  72   HLVAHGRMAEKE-----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI-KIAD  125
             +  H   A++       +    Q+  ++ + H   I HRD+K +NLLLD +  + K+ D
Sbjct  141  RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD  200

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            FG +     G+   ++  S  Y APEL  G       +D+WS G VL  L+ G   F G 
Sbjct  201  FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD  260

Query  186  T  186
            +
Sbjct  261  S  261


>gi|55977123|sp|P68400|CSK21_HUMAN  Casein kinase II, alpha chain (CK II)
Length=391

 Score = 67.8 bits (164),  Expect = 3e-11
 Identities = 50/177 (28%), Positives = 91/177 (51%), Gaps = 12/177 (6%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCH-PHIIRLYQVME--TERMIYLVTEYASG  66
            KV +KI+   +      KKI RE++I++ L   P+II L  +++    R   LV E+ + 
Sbjct  64   KVVVKILKPVKK-----KKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNN  118

Query  67   GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD-ANLNIKIAD  125
             + F  L  +  + + + R    +I+ A+ +CH   I+HRD+K  N+++D  +  +++ D
Sbjct  119  TD-FKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID  175

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            +G +  + PGQ       S  +  PEL    +     +D+WSLG +L  ++    PF
Sbjct  176  WGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPF  232


>gi|23831382|sp|Q13523|PRP4B_HUMAN  Serine/threonine-protein kinase PRP4 homolog (PRP4 pre-mRNA processing 
factor 4 homolog) (PRP4 kinase)
Length=1007

 Score = 67.4 bits (163),  Expect = 4e-11
 Identities = 76/298 (25%), Positives = 134/298 (44%), Gaps = 47/298 (15%)

Query  10    KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHP------HIIRLYQVMETERMIYLVTEY  63
             +VA+KII   +L +   K   +E++ +K L         H +RL++    ++ + LV E 
Sbjct  713   EVAVKIIRNNELMQ---KTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEP  769

Query  64    ASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN  120
              S   + + L  +G+   +  K  R   +Q+  A+      NI+H D+K +N+L++ +  
Sbjct  770   LSMN-LREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKT  828

Query  121   I-KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA  179
             I K+ DFG ++      +   +  S  Y APE+  GK YD   +D+WS+G  LY L  G 
Sbjct  829   ILKLCDFGSASHVADNDITP-YLVSRFYRAPEIIIGKSYDYG-IDMWSVGCTLYELYTGK  886

Query  180   LPFDGSTLQNLRARVLSGKFRIPFFM-STGYF--HLLGSHCNVVLNAKDKRLK-------  229
             + F G T  ++    +  K ++P  M   G F       + N +    DK  +       
Sbjct  887   ILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM  946

Query  230   -------------AGCLSIAE--------CEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
                           GC  + E         + L+  +L+LDP KR+S+ Q  +H +++
Sbjct  947   STINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ  1004


>gi|6685614|sp|O95382|M3K6_HUMAN  Mitogen-activated protein kinase kinase kinase 6
Length=1011

 Score = 67.4 bits (163),  Expect = 4e-11
 Identities = 52/181 (28%), Positives = 88/181 (48%), Gaps = 10/181 (5%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +V I I +  + D    + +  E+ + + L H +I+R          + +  E   GG +
Sbjct  394  RVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSL  453

Query  70   FDHLVA-HGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN-IKIAD  125
               L +  G + + E+   F  +QI+  + + H  +IVHRD+K +N+L++     +KI+D
Sbjct  454  SSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISD  513

Query  126  FGFSNL---FTPGQLLKTWCGSPPYAAPELF-EGKEYDGPKVDIWSLGVVLYVLVCGALP  181
            FG S      TP    +T+ G+  Y APE+  +G    G   DIWSLG  +  +  G  P
Sbjct  514  FGTSKRLAGITP--CTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPP  571

Query  182  F  182
            F
Sbjct  572  F  572


>gi|12643404|sp|O60674|JAK2_HUMAN  Tyrosine-protein kinase JAK2 (Janus kinase 2) (JAK-2)
Length=1132

 Score = 67.4 bits (163),  Expect = 4e-11
 Identities = 53/178 (29%), Positives = 84/178 (47%), Gaps = 22/178 (12%)

Query  11    VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYASGGE  68
             VA+K +  +   EE+L+   RE++I+K L H +I++   V  +   R + L+ EY   G 
Sbjct  879   VAVKKLQHST--EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGS  936

Query  69    IFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
             + D+L  H  R+   +  +   QI   + +   +  +HRDL   N+L++    +KI DFG
Sbjct  937   LRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFG  996

Query  128   FSNLF----------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
              + +            PG+    W     YA   L E K       D+WS GVVLY L
Sbjct  997   LTKVLPQDKEYYKVKEPGESPIFW-----YAPESLTESK--FSVASDVWSFGVVLYEL  1047


 Score = 48.1 bits (113),  Expect = 2e-05
 Identities = 42/178 (23%), Positives = 75/178 (42%), Gaps = 14/178 (7%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +V +K++DK   +    +  F    +M  L H H++  Y V        LV E+   G +
Sbjct  577  EVLLKVLDKAHRNYS--ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSL  634

Query  70   FDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN--------  120
              +L  +        + +  KQ+  A++F     ++H ++ A+N+LL    +        
Sbjct  635  DTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPF  694

Query  121  IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
            IK++D G S    P  +L+      P+  PE  E  +      D WS G  L+ +  G
Sbjct  695  IKLSDPGISITVLPKDILQE---RIPWVPPECIENPKNLNLATDKWSFGTTLWEICSG  749


>gi|1169123|sp|P42679|MATK_HUMAN  Megakaryocyte-associated tyrosine-protein kinase (Tyrosine-protein 
kinase CTK) (Protein kinase HYL) (Hematopoietic consensus 
tyrosine-lacking kinase)
Length=507

 Score = 67.4 bits (163),  Expect = 4e-11
 Identities = 53/189 (28%), Positives = 91/189 (48%), Gaps = 7/189 (3%)

Query  32   EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARR-KFK-  89
            E  +M  + H +++RL  V+   + +Y+V E+ S G + + L   GR     A+  +F  
Sbjct  276  ETAVMTKMQHENLVRLLGVI-LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSL  334

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAA  149
             +   + +   + +VHRDL A N+L+  +L  K++DFG +     G  L +      + A
Sbjct  335  HVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKG--LDSSRLPVKWTA  392

Query  150  PELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTG  208
            PE  +  ++   K D+WS GV+L+ V   G  P+   +L+ +   V  G    P     G
Sbjct  393  PEALKHGKFTS-KSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPG  451

Query  209  YFHLLGSHC  217
              H+L S C
Sbjct  452  PVHVLMSSC  460


>gi|1174527|sp|P43405|KSYK_HUMAN  Tyrosine-protein kinase SYK (Spleen tyrosine kinase)
Length=635

 Score = 67.0 bits (162),  Expect = 5e-11
 Identities = 53/195 (27%), Positives = 87/195 (44%), Gaps = 11/195 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+KI+     D     ++  E  +M+ L +P+I+R+  + E E  + LV E A  G + 
Sbjct  399  VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLN  457

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
             +L  +  + +K       Q+   + +    N VHRDL A N+LL      KI+DFG S 
Sbjct  458  KYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK  517

Query  131  L------FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFD  183
                   +   Q    W     + APE     ++   K D+WS GV+++     G  P+ 
Sbjct  518  ALRADENYYKAQTHGKW--PVKWYAPECINYYKFSS-KSDVWSFGVLMWEAFSYGQKPYR  574

Query  184  GSTLQNLRARVLSGK  198
            G     + A +  G+
Sbjct  575  GMKGSEVTAMLEKGE  589


>gi|119534|sp|P21860|ERBB3_HUMAN  Receptor tyrosine-protein kinase erbB-3 precursor (c-erbB3) (Tyrosine 
kinase-type cell surface receptor HER3)
Length=1342

 Score = 67.0 bits (162),  Expect = 5e-11
 Identities = 54/182 (29%), Positives = 91/182 (50%), Gaps = 8/182 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            V IK+I+      ++ + +   +  +  L H HI+RL  +     +  LVT+Y   G + 
Sbjct  739  VCIKVIEDKS-GRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSL-QLVTQYLPLGSLL  796

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            DH+  H G +  +       QI   +Y+     +VHR+L A N+LL +   +++ADFG +
Sbjct  797  DHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA  856

Query  130  NLFTPG--QLLKTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS  185
            +L  P   QLL +   +P  + A E     +Y   + D+WS GV ++ L+  GA P+ G 
Sbjct  857  DLLPPDDKQLLYSEAKTPIKWMALESIHFGKYT-HQSDVWSYGVTVWELMTFGAEPYAGL  915

Query  186  TL  187
             L
Sbjct  916  RL  917


>gi|68571767|sp|P80192|M3K9_HUMAN  Mitogen-activated protein kinase kinase kinase 9 (Mixed lineage 
kinase 1)
Length=1104

 Score = 66.6 bits (161),  Expect = 7e-11
 Identities = 55/193 (28%), Positives = 93/193 (48%), Gaps = 16/193 (8%)

Query  5    FQFAAKVAIKII--DKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE  62
            F    +VA+K    D  +   + ++ + +E ++  ML HP+II L  V   E  + LV E
Sbjct  162  FWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVME  221

Query  63   YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIV---HRDLKAENLLL----  115
            +A GG + + +++  R+          QI   + + H   IV   HRDLK+ N+L+    
Sbjct  222  FARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKV  280

Query  116  ----DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV  171
                 +N  +KI DFG +  +     +    G+  + APE+     +     D+WS GV+
Sbjct  281  ENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAPEVIRASMFSKGS-DVWSYGVL  338

Query  172  LYVLVCGALPFDG  184
            L+ L+ G +PF G
Sbjct  339  LWELLTGEVPFRG  351


>gi|74762512|sp|Q8N165|PDK1L_HUMAN  Serine/threonine-protein kinase PDIK1L (PDLIM1-interacting kinase 
1 like)
Length=341

 Score = 66.6 bits (161),  Expect = 7e-11
 Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 34/218 (15%)

Query  57   IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLL  115
            ++ V ++  GG++ ++L++  R   ++    F  Q+ +A+ F H   I+HRDLK +N+L+
Sbjct  115  LWFVMDFCDGGDMNEYLLS--RKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILI  172

Query  116  --------DANLNIKIADFGFSNLFT-PGQ-----------LLKTWCGSPPYAAPELFEG  155
                    D    +K+ADFG S + +  GQ            L T CG+  Y APE++EG
Sbjct  173  SQTRLDTSDLEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG  232

Query  156  KEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGS  215
              +   K DI++LG++++ ++      D  T + L    +     I   +  G   L   
Sbjct  233  --HYTAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEI---VPVGEALLENP  287

Query  216  HCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKR  253
               +++  K K +          + LI+ ML  +P  R
Sbjct  288  KMELLIPVKKKSMN------GRMKQLIKEMLAANPQDR  319


>gi|19860819|sp|P54760|EPHB4_HUMAN  Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor 
HTK)
Length=987

 Score = 66.6 bits (161),  Expect = 7e-11
 Identities = 53/200 (26%), Positives = 93/200 (46%), Gaps = 11/200 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + K    E   ++   E  IM    HP+IIRL  V+     + ++TE+   G + 
Sbjct  644  VAIKTL-KGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALD  702

Query  71   DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L +  G+    +     + I + + +    + VHRDL A N+L+++NL  K++DFG S
Sbjct  703  SFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLS  762

Query  130  NLFTPGQLLKTWCGS------PPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
                      T+  S        + APE    +++     D WS G+V++ V+  G  P+
Sbjct  763  RFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSAS-DAWSYGIVMWEVMSFGERPY  821

Query  183  DGSTLQNLRARVLSGKFRIP  202
               + Q++    +   +R+P
Sbjct  822  WDMSNQDV-INAIEQDYRLP  840


>gi|50403745|sp|P52333|JAK3_HUMAN  Tyrosine-protein kinase JAK3 (Janus kinase 3) (JAK-3) (Leukocyte 
janus kinase) (L-JAK)
Length=1124

 Score = 66.6 bits (161),  Expect = 7e-11
 Identities = 55/180 (30%), Positives = 83/180 (46%), Gaps = 22/180 (12%)

Query  9     AKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYASG  66
             A VA+K +  +  D++  +   RE+QI+K L    I++   V      + + LV EY   
Sbjct  850   ALVAVKQLQHSGPDQQ--RDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPS  907

Query  67    GEIFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD  125
             G + D L  H  R+          QI   + +   R  VHRDL A N+L+++  ++KIAD
Sbjct  908   GCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIAD  967

Query  126   FGFSNLF----------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
             FG + L            PGQ    W  +P   +  +F  +       D+WS GVVLY L
Sbjct  968   FGLAKLLPLDKDYYVVREPGQSPIFWY-APESLSDNIFSRQS------DVWSFGVVLYEL  1020


 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 37/177 (20%), Positives = 74/177 (41%), Gaps = 15/177 (8%)

Query  10   KVAIKIIDKTQLDEENLKKIFREV-QIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            +V +K++D      +N  + F E   +M  + + H++ L+ V        +V E+   G 
Sbjct  552  EVLLKVMDAKH---KNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDST-MVQEFVHLGA  607

Query  69   IFDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLL------DANLNI  121
            I  +L   G +     + +  KQ+  A+ +   + + H ++ A  +LL       +   I
Sbjct  608  IDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFI  667

Query  122  KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
            K++D G S      ++L       P+ APE     +    + D W  G  ++ +  G
Sbjct  668  KLSDPGVSPAVLSLEMLTDRI---PWVAPECLREAQTLSLEADKWGFGATVWEVFSG  721


>gi|266423|sp|Q00534|CDK6_HUMAN  Cell division protein kinase 6 (Serine/threonine-protein kinase 
PLSTIRE)
Length=326

 Score = 66.6 bits (161),  Expect = 7e-11
 Identities = 52/172 (30%), Positives = 87/172 (50%), Gaps = 14/172 (8%)

Query  11   VAIKIIDKTQLDEENLK-KIFREVQIMKMLC---HPHIIRLYQVM-----ETERMIYLVT  61
            VA+K + + Q  EE +     REV +++ L    HP+++RL+ V      + E  + LV 
Sbjct  40   VALKRV-RVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVF  98

Query  62   EYASGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL  119
            E+         D +   G   E      F Q++  + F H   +VHRDLK +N+L+ ++ 
Sbjct  99   EHVDQDLTTYLDKVPEPGVPTETIKDMMF-QLLRGLDFLHSHRVVHRDLKPQNILVTSSG  157

Query  120  NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV  171
             IK+ADFG + +++    L +   +  Y APE+     Y  P VD+WS+G +
Sbjct  158  QIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGCI  208


>gi|25009462|sp|Q96S53|TESK2_HUMAN  Dual specificity testis-specific protein kinase 2 (Testicular 
protein kinase 2)
Length=571

 Score = 66.6 bits (161),  Expect = 7e-11
 Identities = 43/158 (27%), Positives = 78/158 (49%), Gaps = 7/158 (4%)

Query  25   NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEA  84
            N   + +EVQ+M  L HP+I+R   V   +  ++ +TEY + G +   L ++  +     
Sbjct  94   NRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVR  153

Query  85   RRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFGFSNLF---TPGQLL  138
             +    I   + + H + I HRDL ++N L+  + N     +ADFG +      + G   
Sbjct  154  VKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRDENGYSAVVADFGLAEKIPDVSMGSEK  213

Query  139  KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
                GSP + APE+   + Y+  K D++S G++L  ++
Sbjct  214  LAVVGSPFWMAPEVLRDEPYN-EKADVFSYGIILCEII  250


>gi|52783106|sp|O95835|LATS1_HUMAN  Serine/threonine-protein kinase LATS1 (Large tumor suppressor 
homolog 1) (WARTS protein kinase) (h-warts)
Length=1130

 Score = 66.6 bits (161),  Expect = 7e-11
 Identities = 52/201 (25%), Positives = 84/201 (41%), Gaps = 49/201 (24%)

Query  44   IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI  103
            ++RLY   + +  +Y V +Y  GG++   L+  G   E  AR    ++  AV   H    
Sbjct  765  VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF  824

Query  104  VHRDLKAENLLLDANLNIKIADFG--------------------------FSNLFTP---  134
            +HRD+K +N+L+D + +IK+ DFG                          FSN +     
Sbjct  825  IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSS  884

Query  135  ---GQLLK----------------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
               G  LK                +  G+P Y APE+     Y     D WS+GV+L+ +
Sbjct  885  CRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYT-QLCDWWSVGVILFEM  943

Query  176  VCGALPFDGSTLQNLRARVLS  196
            + G  PF   T    + +V++
Sbjct  944  LVGQPPFLAQTPLETQMKVIN  964


>gi|60393639|sp|Q13546|RIPK1_HUMAN  Receptor-interacting serine/threonine-protein kinase 2 (Serine/threonine-protein 
kinase RIP) (Cell death protein RIP) (Receptor-interacting 
protein)
Length=671

 Score = 66.2 bits (160),  Expect = 9e-11
 Identities = 47/177 (26%), Positives = 81/177 (45%), Gaps = 15/177 (8%)

Query  24   ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKE  83
            E+ + +  E ++M  L H  +++L  V+  E    LV EY   G +   L A        
Sbjct  55   EHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSV  114

Query  84   ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL------  137
              R   +I+  + + H + ++H+DLK EN+L+D + +IKIAD G ++     +L      
Sbjct  115  KGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHN  174

Query  138  --------LKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
                     K   G+  Y APE L +       K D++S  VVL+ +     P++ +
Sbjct  175  ELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENA  231


>gi|55976573|sp|Q99640|PMYT1_HUMAN  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory 
kinase (Myt1 kinase)
Length=499

 Score = 66.2 bits (160),  Expect = 9e-11
 Identities = 49/161 (30%), Positives = 71/161 (44%), Gaps = 5/161 (3%)

Query  41   HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCH  99
            HP  +RL Q  E   ++YL TE   G  +  H  A G  + E +     +  + A+   H
Sbjct  167  HPCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLH  225

Query  100  CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD  159
             + +VH D+K  N+ L      K+ DFG           +   G P Y APEL +G    
Sbjct  226  SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSY--  283

Query  160  GPKVDIWSLGVVLYVLVCG-ALPFDGSTLQNLRARVLSGKF  199
            G   D++SLG+ +  + C   LP  G   Q LR   L  +F
Sbjct  284  GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEF  324


>gi|13432140|sp|P22455|FGFR4_HUMAN  Fibroblast growth factor receptor 4 precursor (FGFR-4) (CD334 
antigen)
Length=802

 Score = 66.2 bits (160),  Expect = 9e-11
 Identities = 57/211 (27%), Positives = 100/211 (47%), Gaps = 23/211 (10%)

Query  8    AAKVAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASG  66
            A+ VA+K++ K    +++L  +  E+++MK++  H +II L  V   E  +Y++ E A+ 
Sbjct  497  ASTVAVKML-KDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK  555

Query  67   GEIFDHLVAHGRMA---------EKEARRKFKQIVTAVY-------FCHCRNIVHRDLKA  110
            G + + L A                E    F  +V+  Y       +   R  +HRDL A
Sbjct  556  GNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAA  615

Query  111  ENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWS  167
             N+L+  +  +KIADFG +  +       KT  G  P  + APE    + Y   + D+WS
Sbjct  616  RNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYT-HQSDVWS  674

Query  168  LGVVLY-VLVCGALPFDGSTLQNLRARVLSG  197
             G++L+ +   G  P+ G  ++ L + +  G
Sbjct  675  FGILLWEIFTLGGSPYPGIPVEELFSLLREG  705


>gi|6831583|sp|O14733|MP2K7_HUMAN  Dual specificity mitogen-activated protein kinase kinase 7 (MAP 
kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating 
kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 
2) (JNKK 2)
Length=419

 Score = 66.2 bits (160),  Expect = 9e-11
 Identities = 47/179 (26%), Positives = 83/179 (46%), Gaps = 9/179 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            +A+K + ++   EEN + +     ++K    P+I++ +    T   +++  E    G   
Sbjct  146  IAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTCA  203

Query  71   DHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRN-IVHRDLKAENLLLDANLNIKIADFG  127
            + L     G + E+   +    IV A+Y+   ++ ++HRD+K  N+LLD    IK+ DFG
Sbjct  204  EKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFG  263

Query  128  FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP----KVDIWSLGVVLYVLVCGALPF  182
             S      +      G   Y APE  +  +   P    + D+WSLG+ L  L  G  P+
Sbjct  264  ISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPY  322


>gi|120050|sp|P22607|FGFR3_HUMAN  Fibroblast growth factor receptor 3 precursor (FGFR-3) (CD333 
antigen)
Length=806

 Score = 66.2 bits (160),  Expect = 9e-11
 Identities = 56/201 (27%), Positives = 97/201 (48%), Gaps = 23/201 (11%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VA+K++ K    +++L  +  E+++MKM+  H +II L         +Y++ EYA+ G +
Sbjct  505  VAVKML-KDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL  563

Query  70   FDHLVAH---------GRMAEKEARRKFKQIVTAVY-------FCHCRNIVHRDLKAENL  113
             + L A                E +  FK +V+  Y       +   +  +HRDL A N+
Sbjct  564  REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV  623

Query  114  LLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGV  170
            L+  +  +KIADFG + ++       KT  G  P  + APE    + Y   + D+WS GV
Sbjct  624  LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT-HQSDVWSFGV  682

Query  171  VLY-VLVCGALPFDGSTLQNL  190
            +L+ +   G  P+ G  ++ L
Sbjct  683  LLWEIFTLGGSPYPGIPVEEL  703


>gi|74761953|sp|Q9UHD2|TBK1_HUMAN  Serine/threonine-protein kinase TBK1 (TANK-binding kinase 1) 
(T2K) (NF-kappa-B-activating kinase)
Length=729

 Score = 66.2 bits (160),  Expect = 9e-11
 Identities = 49/170 (28%), Positives = 81/170 (47%), Gaps = 20/170 (11%)

Query  31   REVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLV----AHGRMAEKEA  84
            RE +++K L H +I++L+ + E  T R   L+ E+   G ++  L     A+G + E E 
Sbjct  54   REFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG-LPESEF  112

Query  85   RRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTPGQLLKT  140
                + +V  +       IVHRD+K  N++     D     K+ DFG +      +   +
Sbjct  113  LIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVS  172

Query  141  WCGSPPYAAPELFEG--------KEYDGPKVDIWSLGVVLYVLVCGALPF  182
              G+  Y  P+++E         K+Y G  VD+WS+GV  Y    G+LPF
Sbjct  173  LYGTEEYLHPDMYERAVLRKDHQKKY-GATVDLWSIGVTFYHAATGSLPF  221


>gi|6685642|sp|O15264|MK13_HUMAN  Mitogen-activated protein kinase 13 (Stress-activated protein 
kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP 
kinase p38 delta)
Length=365

 Score = 65.9 bits (159),  Expect = 1e-10
 Identities = 65/282 (23%), Positives = 116/282 (41%), Gaps = 47/282 (16%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMI------YLVTEY  63
            KVAIK + +    E   K+ +RE+ ++K + H ++I L  V      +      YLV  +
Sbjct  50   KVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPF  109

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI  123
                      +     +E++ +    Q++  + + H   +VHRDLK  NL ++ +  +KI
Sbjct  110  MQTDL---QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKI  166

Query  124  ADFGF---SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL  180
             DFG    ++    G ++  W     Y APE+     +    VDIWS+G ++  ++ G  
Sbjct  167  LDFGLARHADAEMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT  221

Query  181  PFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSI-----  235
             F G    +   ++L    ++     T +          V    DK  K+   S+     
Sbjct  222  LFKGKDYLDQLTQIL----KVTGVPGTEF----------VQKLNDKAAKSYIQSLPQTPR  267

Query  236  -----------AECEHLIRHMLVLDPNKRLSMEQICKHKWMK  266
                        +   L+  ML LD +KRL+  Q   H + +
Sbjct  268  KDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE  309


>gi|52783149|sp|Q9NRM7|LATS2_HUMAN  Serine/threonine-protein kinase LATS2 (Large tumor suppressor 
homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated 
during mitosis protein) (Warts-like kinase)
Length=1088

 Score = 65.9 bits (159),  Expect = 1e-10
 Identities = 53/227 (23%), Positives = 90/227 (39%), Gaps = 49/227 (21%)

Query  18   KTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHG  77
            K  L+   +  +  E  I+    +  +++LY   + +  +Y V +Y  GG++   L+   
Sbjct  702  KDVLNRNQVVHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRME  761

Query  78   RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF-----  132
               E  AR    ++  A+   H    +HRD+K +N+L+D + +IK+ DFG    F     
Sbjct  762  VFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHN  821

Query  133  ---------------------------TPGQLLKT----------------WCGSPPYAA  149
                                         G  LKT                  G+P Y A
Sbjct  822  SKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIA  881

Query  150  PELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLS  196
            PE+   K Y     D WS+GV+L+ ++ G  PF   T    + +V++
Sbjct  882  PEVLLRKGYT-QLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVIN  927


>gi|27923858|sp|Q8TDR2|STK35_HUMAN  Serine/threonine-protein kinase 35 (CLP-36-interacting kinase) 
(Clik1) (PDLIM1-interacting kinase 1)
Length=401

 Score = 65.5 bits (158),  Expect = 1e-10
 Identities = 46/167 (27%), Positives = 81/167 (48%), Gaps = 26/167 (15%)

Query  46   RLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIV  104
            R+    E    ++ V E+  GG++  ++++  R  +    + F  Q+ +A+ F H  +IV
Sbjct  167  RILGYAEEPCYLWFVMEFCEGGDLNQYVLS--RRPDPATNKSFMLQLTSAIAFLHKNHIV  224

Query  105  HRDLKAENLLLDANLN---IKIADFGFS------------------NLFTPGQLLKTWCG  143
            HRDLK +N+L+        +K+ADFG S                  N+      L + CG
Sbjct  225  HRDLKPDNILITERSGTPILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACG  284

Query  144  SPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  190
            S  Y APE++EG  +   K DI++LG++++ ++      D  T + L
Sbjct  285  SDFYMAPEVWEG--HYTAKADIFALGIIIWAMIERITFIDSETKKEL  329


>gi|1170596|sp|P45985|MP2K4_HUMAN  Dual specificity mitogen-activated protein kinase kinase 4 (MAP 
kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal 
kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1)
Length=399

 Score = 65.5 bits (158),  Expect = 1e-10
 Identities = 52/184 (28%), Positives = 85/184 (46%), Gaps = 16/184 (8%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQI-MKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +A+K I  T +DE+  K++  ++ + M+    P+I++ Y  +  E   ++  E  S    
Sbjct  128  MAVKRIRST-VDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS--  184

Query  70   FDHLVAH-----GRMAEKEARRKFKQIVTAVYFCHCRN---IVHRDLKAENLLLDANLNI  121
            FD    +       +  +E   K   + T     H +    I+HRD+K  N+LLD + NI
Sbjct  185  FDKFYKYVYSVLDDVIPEEILGKIT-LATVKALNHLKENLKIIHRDIKPSNILLDRSGNI  243

Query  122  KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCG  178
            K+ DFG S             G  PY APE  +    ++    + D+WSLG+ LY L  G
Sbjct  244  KLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATG  303

Query  179  ALPF  182
              P+
Sbjct  304  RFPY  307


>gi|50401181|sp|Q9NWZ3|IRAK4_HUMAN  Interleukin-1 receptor-associated kinase 4 (IRAK-4) (NY-REN-64 
antigen)
Length=460

 Score = 65.1 bits (157),  Expect = 2e-10
 Identities = 49/172 (28%), Positives = 75/172 (43%), Gaps = 9/172 (5%)

Query  14   KIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDH  72
            K+     +  E LK+ F +E+++M    H +++ L         + LV  Y   G + D 
Sbjct  214  KLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDR  273

Query  73   LVAHGRMAEKEARRKFK---QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-  128
            L             + K        + F H  + +HRD+K+ N+LLD     KI+DFG  
Sbjct  274  LSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLA  333

Query  129  --SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
              S  F    +     G+  Y APE   G+    PK DI+S GVVL  ++ G
Sbjct  334  RASEKFAQTVMTSRIVGTTAYMAPEALRGE--ITPKSDIYSFGVVLLEIITG  383


>gi|3913590|sp|Q15303|ERBB4_HUMAN  Receptor tyrosine-protein kinase erbB-4 precursor (p180erbB4) 
(Tyrosine kinase-type cell surface receptor HER4)
Length=1308

 Score = 65.1 bits (157),  Expect = 2e-10
 Identities = 52/179 (29%), Positives = 89/179 (49%), Gaps = 8/179 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIKI+++T   + N++    E  IM  + HPH++RL  V  +   I LVT+    G + 
Sbjct  748  VAIKILNETTGPKANVE-FMDEALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLL  805

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            +++  H   +  +       QI   + +   R +VHRDL A N+L+ +  ++KI DFG +
Sbjct  806  EYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLA  865

Query  130  NLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDG  184
             L    +      G      + A E    +++   + D+WS GV ++ L+  G  P+DG
Sbjct  866  RLLEGDEKEYNADGGKMPIKWMALECIHYRKFT-HQSDVWSYGVTIWELMTFGGKPYDG  923


>gi|71153820|sp|Q5TCX8|M3KL4_HUMAN  Mitogen-activated protein kinase kinase kinase (Mixed lineage 
kinase 4)
Length=1036

 Score = 65.1 bits (157),  Expect = 2e-10
 Identities = 55/183 (30%), Positives = 85/183 (46%), Gaps = 27/183 (14%)

Query  27   KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEA--  84
            + + RE ++  ML HP+II L  V   +  + LV E+A GG +   L A     +  A  
Sbjct  166  ESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPG  225

Query  85   -RRKFK-----------QIVTAVYFCHCR---NIVHRDLKAENLLL--------DANLNI  121
             RR  +           QI   + + H      I+HRDLK+ N+LL          N  +
Sbjct  226  PRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTL  285

Query  122  KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP  181
            KI DFG +  +     + T  G+  + APE+ +   +     DIWS GV+L+ L+ G +P
Sbjct  286  KITDFGLAREWHRTTKMST-AGTYAWMAPEVIKSSLFSKGS-DIWSYGVLLWELLTGEVP  343

Query  182  FDG  184
            + G
Sbjct  344  YRG  346


>gi|24211444|sp|Q96Q40|AL2S7_HUMAN  Serine/threonine-protein kinase ALS2CR7 (Amyotrophic lateral 
sclerosis 2 chromosomal region candidate gene 7 protein)
Length=384

 Score = 65.1 bits (157),  Expect = 2e-10
 Identities = 46/176 (26%), Positives = 84/176 (47%), Gaps = 4/176 (2%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K+I     +      I RE  ++K L H +I+ L+ ++ T+  +  V EY    ++ 
Sbjct  78   VALKVISMNAEEGVPFTAI-REASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHT-DLA  135

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             ++  H G +     R    Q++  + + H ++++HRDLK +NLL+     +K+ADFG +
Sbjct  136  QYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLA  195

Query  130  NLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
               + P Q   +   +  Y  P+   G      ++DIW  G +   +  G   F G
Sbjct  196  RAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPG  251


>gi|60391917|sp|Q9BWU1|CD2L6_HUMAN  Cell division cycle 2-like protein kinase 6 (CDC2-related protein 
kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 
11)
Length=502

 Score = 64.7 bits (156),  Expect = 3e-10
 Identities = 77/306 (25%), Positives = 127/306 (41%), Gaps = 48/306 (15%)

Query  31   REVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYASGGEIFDHLVAHGRMAEKE-----  83
            RE+ +++ L HP++I L +V    ++R ++L+ +YA       H++   R ++       
Sbjct  65   REIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHD--LWHIIKFHRASKANKKPMQ  122

Query  84   -----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTP  134
                  +    QI+  +++ H   ++HRDLK  N+L+         +KIAD GF+ LF  
Sbjct  123  LPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF--  180

Query  135  GQLLKTWCGSPP------YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF-----D  183
               LK      P      Y APEL  G  +    +DIW++G +   L+     F     D
Sbjct  181  NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED  240

Query  184  GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKR--LKAGCLSIAECEH-  240
              T        L   F +  F +   +  +          KD R    A    I   E  
Sbjct  241  IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH  300

Query  241  ----------LIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQV  290
                      L++ +L +DP KR++ EQ  +  + +  D  P  D + A CQ    +R+ 
Sbjct  301  KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQ-EDPLPTLD-VFAGCQIPYPKREF  358

Query  291  DPLNED  296
              LNED
Sbjct  359  --LNED  362


>gi|2499599|sp|Q13164|MK07_HUMAN  Mitogen-activated protein kinase 7 (Extracellular signal-regulated 
kinase 5) (ERK-5) (ERK4) (BMK1 kinase)
Length=815

 Score = 64.7 bits (156),  Expect = 3e-10
 Identities = 76/344 (22%), Positives = 139/344 (40%), Gaps = 60/344 (17%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE------RMIYLVTEY  63
            +VAIK I        N K+  RE++I+K   H +II +  ++         + +Y+V + 
Sbjct  79   QVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDL  138

Query  64   ASGGEIFDHLVAHGR--MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI  121
                    H + H    +  +  R    Q++  + + H   ++HRDLK  NLL++ N  +
Sbjct  139  MESDL---HQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCEL  195

Query  122  KIADFGFSN--LFTPGQ---LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
            KI DFG +     +P +    +  +  +  Y APEL          +D+WS+G +   ++
Sbjct  196  KIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEML  255

Query  177  CGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKD-KRLKAGCLSI  235
                 F G    +    ++                +LG+    V+ A   +R++A   S+
Sbjct  256  ARRQLFPGKNYVHQLQLIMM---------------VLGTPSPAVIQAVGAERVRAYIQSL  300

Query  236  ----------------AECEHLIRHMLVLDPNKRLSMEQICKHKWM-KLGDAD------P  272
                             +   L+  ML  +P+ R+S     +H ++ K  D D      P
Sbjct  301  PPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAP  360

Query  273  NFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLR  316
             FD    + + L  ER    + E ++  +ED    +E   Q +R
Sbjct  361  PFD-FAFDREALTRER----IKEAIVAEIEDFHARREGIRQQIR  399


>gi|46577085|sp|Q8WXR4|MYO3B_HUMAN  Myosin IIIB
Length=1341

 Score = 64.7 bits (156),  Expect = 3e-10
 Identities = 56/196 (28%), Positives = 94/196 (47%), Gaps = 21/196 (10%)

Query  12   AIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETER-----MIYLVTEYA  64
            A+KI+D  + +DEE    I  E  I++ L  HP++++ Y +           ++LV E  
Sbjct  54   AVKILDPVSDMDEE----IEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLELC  109

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIV----TAVYFCHCRNIVHRDLKAENLLLDANLN  120
            +GG + + +    R  ++        I+      +   H   I+HRD+K  N+LL     
Sbjct  110  NGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGG  169

Query  121  IKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFE-GKEYDG---PKVDIWSLGVVLYVL  175
            +K+ DFG S   T  +L + T  G+P + APE+    ++YD     + D+WSLG+    L
Sbjct  170  VKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIEL  229

Query  176  VCGALP-FDGSTLQNL  190
              G  P FD   ++ L
Sbjct  230  GDGDPPLFDMHPVKTL  245


>gi|1168867|sp|P11802|CDK4_HUMAN  Cell division protein kinase 4 (Cyclin-dependent kinase 4) (PSK-J3)
Length=303

 Score = 64.3 bits (155),  Expect = 3e-10
 Identities = 48/151 (31%), Positives = 74/151 (49%), Gaps = 12/151 (7%)

Query  31   REVQIMKMLC---HPHIIRLYQVMETERM-----IYLVTEYASGG--EIFDHLVAHGRMA  80
            REV +++ L    HP+++RL  V  T R      + LV E+         D     G  A
Sbjct  55   REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA  114

Query  81   EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKT  140
            E   +   +Q +  + F H   IVHRDLK EN+L+ +   +K+ADFG + +++    L  
Sbjct  115  ET-IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP  173

Query  141  WCGSPPYAAPELFEGKEYDGPKVDIWSLGVV  171
               +  Y APE+     Y  P VD+WS+G +
Sbjct  174  VVVTLWYRAPEVLLQSTYATP-VDMWSVGCI  203


>gi|549081|sp|P35590|TIE1_HUMAN  Tyrosine-protein kinase receptor Tie-1 precursor
Length=1138

 Score = 63.9 bits (154),  Expect = 4e-10
 Identities = 59/210 (28%), Positives = 91/210 (43%), Gaps = 32/210 (15%)

Query  12    AIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
             AIK++ K    E + +    E++++ K+  HP+II L    +    +Y+  EYA  G + 
Sbjct  868   AIKML-KEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLL  926

Query  71    DHLVA-------------HGRMAEKEARRKFK---QIVTAVYFCHCRNIVHRDLKAENLL  114
             D L               HG  +   +R+  +        + +   +  +HRDL A N+L
Sbjct  927   DFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVL  986

Query  115   LDANLNIKIADFGFSN------LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSL  168
             +  NL  KIADFG S         T G+L   W       A E      Y   K D+WS 
Sbjct  987   VGENLASKIADFGLSRGEEVYVKKTMGRLPVRW------MAIESLNYSVYT-TKSDVWSF  1039

Query  169   GVVLYVLV-CGALPFDGSTLQNLRARVLSG  197
             GV+L+ +V  G  P+ G T   L  ++  G
Sbjct  1040  GVLLWEIVSLGGTPYCGMTCAELYEKLPQG  1069


>gi|2497562|sp|Q16288|NTRK3_HUMAN  NT-3 growth factor receptor precursor (Neurotrophic tyrosine 
kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) 
(Trk-C)
Length=839

 Score = 63.9 bits (154),  Expect = 4e-10
 Identities = 55/196 (28%), Positives = 85/196 (43%), Gaps = 36/196 (18%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K +    L     K   RE +++  L H HI++ Y V      + +V EY   G++ 
Sbjct  569  VAVKALKDPTLAAR--KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLN  626

Query  71   DHLVAHGRMA-------EKEARRKF---------KQIVTAVYFCHCRNIVHRDLKAENLL  114
              L AHG  A        ++A+ +           QI + + +   ++ VHRDL   N L
Sbjct  627  KFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCL  686

Query  115  LDANLNIKIADFGFS---------NLFTP-GQLLKTWCGSPPYA-------APELFEGKE  157
            + ANL +KI DFG S          LF P G     WC    +         PE    ++
Sbjct  687  VGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRK  746

Query  158  YDGPKVDIWSLGVVLY  173
            +   + D+WS GV+L+
Sbjct  747  FT-TESDVWSFGVILW  761


>gi|1717829|sp|Q06418|TYRO3_HUMAN  Tyrosine-protein kinase receptor TYRO3 precursor (Tyrosine-protein 
kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein 
kinase DTK) (Protein-tyrosine kinase byk)
Length=890

 Score = 63.9 bits (154),  Expect = 4e-10
 Identities = 47/192 (24%), Positives = 85/192 (44%), Gaps = 19/192 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETER------MIYLVTEY  63
            KVA+K++    +   ++++  RE   MK   HPH+ +L  V    R      +  ++  +
Sbjct  546  KVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPF  605

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC-------RNIVHRDLKAENLLLD  116
               G++   L+A  R+ E       + ++  +    C       RN +HRDL A N +L 
Sbjct  606  MKHGDLHAFLLA-SRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLA  664

Query  117  ANLNIKIADFGFSNLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVVLY  173
             ++ + +ADFG S     G   +  C S     + A E      Y   + D+W+ GV ++
Sbjct  665  EDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYT-VQSDVWAFGVTMW  723

Query  174  -VLVCGALPFDG  184
             ++  G  P+ G
Sbjct  724  EIMTRGQTPYAG  735


>gi|74708170|sp|Q5S007|LRRK2_HUMAN  Leucine-rich repeat protein kinase 2 (Dardarin)
Length=2527

 Score = 63.9 bits (154),  Expect = 4e-10
 Identities = 55/188 (29%), Positives = 92/188 (48%), Gaps = 16/188 (8%)

Query  10    KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
             +VA+KI +K      +L+ + +E+ ++  L HP +I L       RM  LV E AS G +
Sbjct  1902  EVAVKIFNK----HTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRM--LVMELASKGSL  1955

Query  70    FDHLVAHGR--MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL-----DANLNIK  122
              D L+   +  +      R    +   + + H   I++RDLK  N+LL     +A +  K
Sbjct  1956  -DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAK  2014

Query  123   IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALP  181
             IAD+G +  +     +KT  G+P + APE+  G      + D++S G++LY +L  G   
Sbjct  2015  IADYGIAQ-YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRI  2073

Query  182   FDGSTLQN  189
              +G    N
Sbjct  2074  VEGLKFPN  2081


>gi|547807|sp|P07949|RET_HUMAN  Proto-oncogene tyrosine-protein kinase receptor ret precursor 
(C-ret)
Length=1114

 Score = 63.5 bits (153),  Expect = 6e-10
 Identities = 53/203 (26%), Positives = 88/203 (43%), Gaps = 32/203 (15%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K++ K       L+ +  E  ++K + HPH+I+LY     +  + L+ EYA  G + 
Sbjct  755  VAVKML-KENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR  813

Query  71   DHL-----VAHGRMAEKEARRKFK-------------------QIVTAVYFCHCRNIVHR  106
              L     V  G +    +R                       QI   + +     +VHR
Sbjct  814  GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHR  873

Query  107  DLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP---YAAPELFEGKEYDGPK  162
            DL A N+L+     +KI+DFG S +++     +K   G  P    A   LF+       +
Sbjct  874  DLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD--HIYTTQ  931

Query  163  VDIWSLGVVLY-VLVCGALPFDG  184
             D+WS GV+L+ ++  G  P+ G
Sbjct  932  SDVWSFGVLLWEIVTLGGNPYPG  954


>gi|2497560|sp|Q16620|NTRK2_HUMAN  BDNF/NT-3 growth factors receptor precursor (Neurotrophic tyrosine 
kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) 
(Trk-B)
Length=822

 Score = 63.2 bits (152),  Expect = 7e-10
 Identities = 51/179 (28%), Positives = 84/179 (46%), Gaps = 19/179 (10%)

Query  13   IKIIDKTQLD-EENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            I +  KT  D  +N +K F RE +++  L H HI++ Y V      + +V EY   G++ 
Sbjct  567  ILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLN  626

Query  71   DHLVAHG-------------RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA  117
              L AHG              + + +     +QI   + +   ++ VHRDL   N L+  
Sbjct  627  KFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE  686

Query  118  NLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY  173
            NL +KI DFG S ++++            P  +  PE    +++   + D+WSLGVVL+
Sbjct  687  NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT-TESDVWSLGVVLW  744


>gi|74762207|sp|Q5JZY3|EPHAA_HUMAN  Ephrin type-A receptor 10 precursor
Length=1008

 Score = 63.2 bits (152),  Expect = 7e-10
 Identities = 52/196 (26%), Positives = 91/196 (46%), Gaps = 7/196 (3%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+ ++  +  D + L     E   +    H HI+RL  V+     + +VTEY S G + 
Sbjct  674  VAVHMLRDSASDSQRLG-FLAEALTLGQFDHSHIVRLEGVVTRGSTLMIVTEYMSHGALD  732

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
              L  H G++   +       + +A+ +      VHR L A ++L+ ++L  KI+ FG  
Sbjct  733  GFLRRHEGQLVAGQLMGLLPGLASAMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRG  792

Query  130  NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST  186
                   +  T  G  P  +AAPE  +   +     D+WS G++++ V+  G  P+   +
Sbjct  793  PRDRSEAVYTTMSGRSPALWAAPETLQFGHFSSAS-DVWSFGIIMWEVMAFGERPYWDMS  851

Query  187  LQNLRARVLSGKFRIP  202
             Q++   V  G FR+P
Sbjct  852  GQDVIKAVEDG-FRLP  866


>gi|37999491|sp|Q07912|ACK1_HUMAN  Activated CDC42 kinase 1 (ACK-1) (Tyrosine kinase non-receptor 
protein 2)
Length=1036

 Score = 62.8 bits (151),  Expect = 1e-09
 Identities = 53/175 (30%), Positives = 74/175 (42%), Gaps = 20/175 (11%)

Query  11   VAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VA+K +    L + E +    REV  M  L H ++IRLY V+ T  M  +VTE A  G +
Sbjct  155  VAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPM-KMVTELAPLGSL  213

Query  70   FDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
             D L  H G        R   Q+   + +   +  +HRDL A NLLL     +KI DFG 
Sbjct  214  LDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGL  273

Query  129  SNLFTPG----------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY  173
                             ++   WC      APE  + + +     D W  GV L+
Sbjct  274  MRALPQNDDHYVMQEHRKVPFAWC------APESLKTRTFSHAS-DTWMFGVTLW  321


>gi|1709088|sp|P52564|MP2K6_HUMAN  Dual specificity mitogen-activated protein kinase kinase 6 (MAP 
kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
Length=334

 Score = 62.4 bits (150),  Expect = 1e-09
 Identities = 57/226 (25%), Positives = 103/226 (45%), Gaps = 12/226 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQI-MKMLCHPHIIRLYQVMETERMIYLVTEY--ASGG  67
            +A+K I  T   +E  K++  ++ I M+ +  P  +  Y  +  E  +++  E    S  
Sbjct  79   MAVKRIRATVNSQEQ-KRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLD  137

Query  68   EIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCR-NIVHRDLKAENLLLDANLNIKIAD  125
            + +  ++  G+   ++   K    IV A+   H + +++HRD+K  N+L++A   +K+ D
Sbjct  138  KFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD  197

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            FG S             G  PY APE       ++    K DIWSLG+ +  L     P+
Sbjct  198  FGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY  257

Query  183  D--GSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDK  226
            D  G+  Q L+  V     ++P    +  F    S C +  N+K++
Sbjct  258  DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC-LKKNSKER  302


>gi|60391728|sp|Q6Q788|APOA5_HUMAN  Apolipoprotein A-V precursor (Apolipoprotein A5) (ApoAV) (ApoA-V) 
(Regeneration-associated protein 3)
Length=366

 Score = 62.4 bits (150),  Expect = 1e-09
 Identities = 33/112 (29%), Positives = 65/112 (58%), Gaps = 0/112 (0%)

Query  1194  LLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQ  1253
             L D+ +   +  +K  E+L P++      L ++  G+R+++ ++LEEVKA++QPY+ +  
Sbjct  56    LKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAH  115

Query  1254  KKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVD  1305
             +     +E  RQ+++P   +L E    ++ ELQE+L  +GE+ + +    VD
Sbjct  116   ELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVD  167


>gi|119533|sp|P04626|ERBB2_HUMAN  Receptor tyrosine-protein kinase erbB-2 precursor (p185erbB2) 
(C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell 
surface receptor HER2) (MLN 19)
Length=1255

 Score = 62.0 bits (149),  Expect = 2e-09
 Identities = 51/179 (28%), Positives = 88/179 (49%), Gaps = 8/179 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK++ +    + N K+I  E  +M  +  P++ RL  +  T   + LVT+    G + 
Sbjct  750  VAIKVLRENTSPKAN-KEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLL  807

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            DH+  + GR+  ++      QI   + +     +VHRDL A N+L+ +  ++KI DFG +
Sbjct  808  DHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLA  867

Query  130  NLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDG  184
             L    +      G      + A E    + +   + D+WS GV ++ L+  GA P+DG
Sbjct  868  RLLDIDETEYHADGGKVPIKWMALESILRRRFT-HQSDVWSYGVTVWELMTFGAKPYDG  925


>gi|729008|sp|Q08345|DDR1_HUMAN  Epithelial discoidin domain-containing receptor 1 precursor (Epithelial 
discoidin domain receptor 1) (Tyrosine kinase DDR) 
(Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase 
CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase 
RTK 6) (HGK2) (CD167a antigen)
Length=913

 Score = 62.0 bits (149),  Expect = 2e-09
 Identities = 56/203 (27%), Positives = 85/203 (41%), Gaps = 40/203 (19%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+KI+ +    +       +EV+IM  L  P+IIRL  V   +  + ++T+Y   G++ 
Sbjct  652  VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLN  710

Query  71   DHLVAHGRMAEKEAR--------------------RKFKQIVTAVYFCHCRNIVHRDLKA  110
              L AH ++ +K A                         QI + + +    N VHRDL  
Sbjct  711  QFLSAH-QLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLAT  769

Query  111  ENLLLDANLNIKIADFGFSNLFTPGQLLKT---------WCGSPPYAAPELFEGKEYDGP  161
             N L+  N  IKIADFG S     G   +          W      A   +  GK     
Sbjct  770  RNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRW-----MAWECILMGKFTTAS  824

Query  162  KVDIWSLGVVLY--VLVCGALPF  182
              D+W+ GV L+  +++C A PF
Sbjct  825  --DVWAFGVTLWEVLMLCRAQPF  845


>gi|125266|sp|P19784|CSK22_HUMAN  Casein kinase II, alpha' chain (CK II)
Length=350

 Score = 61.2 bits (147),  Expect = 3e-09
 Identities = 47/177 (26%), Positives = 89/177 (50%), Gaps = 12/177 (6%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCH-PHIIRLYQVME--TERMIYLVTEYASG  66
            +V +KI+   +      KKI REV+I++ L    +II+L   ++    +   LV EY + 
Sbjct  65   RVVVKILKPVKK-----KKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINN  119

Query  67   GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD-ANLNIKIAD  125
             + F  L  +  + + + R    +++ A+ +CH + I+HRD+K  N+++D     +++ D
Sbjct  120  TD-FKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID  176

Query  126  FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            +G +  + P Q       S  +  PEL    +     +D+WSLG +L  ++    PF
Sbjct  177  WGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPF  233


>gi|14285588|sp|Q99558|M3K14_HUMAN  Mitogen-activated protein kinase kinase kinase 14 (NF-kappa beta-inducing 
kinase) (Serine/threonine-protein kinase NIK) (HsNIK)
Length=947

 Score = 61.2 bits (147),  Expect = 3e-09
 Identities = 44/164 (26%), Positives = 78/164 (47%), Gaps = 10/164 (6%)

Query  28   KIFREVQIMKM--LCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEAR  85
            ++FR  ++M    L  P I+ LY  +     + +  E   GG +   +   G + E  A 
Sbjct  434  EVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRAL  493

Query  86   RKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN-LNIKIADFGFSNLFTPGQLLKTWC--  142
                Q +  + + H R I+H D+KA+N+LL ++  +  + DFG +    P  L K+    
Sbjct  494  YYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTG  553

Query  143  ----GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
                G+  + APE+  G+  D  KVD+WS   ++  ++ G  P+
Sbjct  554  DYIPGTETHMAPEVVLGRSCDA-KVDVWSSCCMMLHMLNGCHPW  596


>gi|32172458|sp|Q9BQI3|E2AK1_HUMAN  Eukaryotic translation initiation factor 2-alpha kinase 1 (Heme-regulated 
eukaryotic initiation factor eIF-2-alpha kinase) 
(Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) 
(Hemin-sensitive initiation factor 2-alpha kinase)
Length=630

 Score = 60.8 bits (146),  Expect = 4e-09
 Identities = 56/165 (33%), Positives = 78/165 (47%), Gaps = 26/165 (15%)

Query  49   QVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDL  108
            Q+ E     ++V     G E  D       MA   A + F+++V  V++ H   IVHRDL
Sbjct  385  QLCELSLWDWIVERNKRGREYVDESACPYVMANV-ATKIFQELVEGVFYIHNMGIVHRDL  443

Query  109  KAENLLLDA-NLNIKIADFGF---------------SNLFTPGQLLKTWCGSPPYAAPEL  152
            K  N+ L   +  +KI DFG                +   TP    +   G+  YA+PE 
Sbjct  444  KPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRV--GTCLYASPEQ  501

Query  153  FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSG  197
             EG EYD  K D++SLGVVL  L     PF G+ ++  RA VL+G
Sbjct  502  LEGSEYDA-KSDMYSLGVVLLELF---QPF-GTEME--RAEVLTG  539


>gi|6226784|sp|Q15131|CDK10_HUMAN  Cell division protein kinase 10 (Serine/threonine-protein kinase 
PISSLRE)
Length=360

 Score = 60.8 bits (146),  Expect = 4e-09
 Identities = 43/157 (27%), Positives = 77/157 (49%), Gaps = 19/157 (12%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERM--IYLVTEYASG--GEIFDHLVAHGRMAEKEARR  86
            RE+ ++  L HP+I+ L +V+    +  I+LV  Y       + +++      +E + + 
Sbjct  85   REITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTP--FSEAQVKC  142

Query  87   KFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF-------TPGQLLK  139
               Q++  + + H   I+HRDLK  NLL+     +K ADFG +  +       TP +++ 
Sbjct  143  IVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTP-KVVT  201

Query  140  TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
             W     Y APEL  G       +D+W++G +L  L+
Sbjct  202  LW-----YRAPELLLGTTTQTTSIDMWAVGCILAELL  233


>gi|2497564|sp|Q16832|DDR2_HUMAN  Discoidin domain-containing receptor 2 precursor (Discoidin domain 
receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein 
kinase TYRO 10) (Neurotrophic tyrosine kinase, 
receptor-related 3) (CD167b antigen)
Length=855

 Score = 60.8 bits (146),  Expect = 4e-09
 Identities = 43/134 (32%), Positives = 67/134 (50%), Gaps = 12/134 (8%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K++ +   ++       +E++IM  L  P+II L  V  T+  + ++TEY   G++ 
Sbjct  605  VAVKML-RADANKNARNDFLKEIKIMSRLKDPNIIHLLSVCITDDPLCMITEYMENGDLN  663

Query  71   DHLVAHG--RMAEKEARR------KFK--QIVTAVYFCHCRNIVHRDLKAENLLLDANLN  120
              L  H     +  + R       KF   QI + + +    N VHRDL   N L+  N  
Sbjct  664  QFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYT  723

Query  121  IKIADFGFS-NLFT  133
            IKIADFG S NL++
Sbjct  724  IKIADFGMSRNLYS  737


>gi|2811086|sp|P00533|EGFR_HUMAN  Epidermal growth factor receptor precursor (Receptor tyrosine-protein 
kinase ErbB-1)
Length=1210

 Score = 60.1 bits (144),  Expect = 6e-09
 Identities = 54/197 (27%), Positives = 94/197 (47%), Gaps = 9/197 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK + +    + N K+I  E  +M  + +PH+ RL  +  T   + L+T+    G + 
Sbjct  742  VAIKELREATSPKAN-KEILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLL  799

Query  71   DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
            D++  H   +  +       QI   + +   R +VHRDL A N+L+    ++KI DFG +
Sbjct  800  DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLA  859

Query  130  NLF-TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS  185
             L     +      G  P  + A E    + Y   + D+WS GV ++ L+  G+ P+DG 
Sbjct  860  KLLGAEEKEYHAEGGKVPIKWMALESILHRIYT-HQSDVWSYGVTVWELMTFGSKPYDGI  918

Query  186  TLQNLRARVLSGKFRIP  202
                + + +  G+ R+P
Sbjct  919  PASEISSILEKGE-RLP  934


>gi|29427916|sp|Q92918|M4K1_HUMAN  Mitogen-activated protein kinase kinase kinase kinase 1 (MAPK/ERK 
kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) 
(Hematopoietic progenitor kinase)
Length=833

 Score = 60.1 bits (144),  Expect = 6e-09
 Identities = 41/164 (25%), Positives = 86/164 (52%), Gaps = 7/164 (4%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K++ K + D++ +  + +E+ I+K   H +I+  +      + +++  E+   G + 
Sbjct  43   VALKMV-KMEPDDD-VSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQ  100

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
            D     G ++E +     ++++  + + H +  +HRD+K  N+L++    +++ADFG S 
Sbjct  101  DIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISA  160

Query  131  LF--TPGQLLKTWCGSPPYAAPELFEGKEYDG--PKVDIWSLGV  170
                T  + L ++ G+P + APE+       G     DIWSLG+
Sbjct  161  QIGATLARRL-SFIGTPYWMAPEVAAVALKGGYNELCDIWSLGI  203


>gi|50403742|sp|P41279|M3K8_HUMAN  Mitogen-activated protein kinase kinase kinase 8 (COT proto-oncogene 
serine/threonine-protein kinase) (C-COT) (Cancer Osaka 
thyroid oncogene)
Length=467

 Score = 59.7 bits (143),  Expect = 8e-09
 Identities = 41/152 (26%), Positives = 70/152 (46%), Gaps = 3/152 (1%)

Query  32   EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQI  91
            +V+I     H +I  LY  +     ++L  E   GG + + L + G M E E     K +
Sbjct  178  DVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHV  237

Query  92   VTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLL-KTWCGSPPYAAP  150
            +  + F H + ++H D+K  N++  +   + + DFG S   T      K   G+  Y +P
Sbjct  238  LKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSP  296

Query  151  ELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            E+   + +   K DI+SLG  L  +  G  P+
Sbjct  297  EVILCRGH-STKADIYSLGATLIHMQTGTPPW  327


>gi|59896668|sp|Q13470|TNK1_HUMAN  Non-receptor tyrosine-protein kinase TNK1 (CD38 negative kinase 
1)
Length=666

 Score = 59.7 bits (143),  Expect = 8e-09
 Identities = 52/163 (31%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query  26   LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEAR  85
            L    REV +M  L HPH++RL+ ++   + + +V E A  G +   L A          
Sbjct  162  LGDFLREVSVMMNLEHPHVLRLHGLV-LGQPLQMVMELAPLGSLHARLTAPAPTPPLLVA  220

Query  86   RK---FKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTP--GQLLKT  140
                  +Q+  A+ +   R +VHRDL   NLLL +   IK+ADFG   L  P  G   + 
Sbjct  221  LLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFG---LVRPLGGARGRY  277

Query  141  WCGSP---PYA--APELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
              G P   PYA  APE      +     D+W  GV L+ +  G
Sbjct  278  VMGGPRPIPYAWCAPESLRHGAFSSAS-DVWMFGVTLWEMFSG  319


>gi|125060|sp|P23458|JAK1_HUMAN  Tyrosine-protein kinase JAK1 (Janus kinase 1) (JAK-1)
Length=1142

 Score = 59.3 bits (142),  Expect = 1e-08
 Identities = 50/176 (28%), Positives = 91/176 (51%), Gaps = 13/176 (7%)

Query  10    KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE---RMIYLVTEYASG  66
             +VA+K + K +    ++  + +E++I++ L H +I++ Y+ + TE     I L+ E+   
Sbjct  892   QVAVKSL-KPESGGNHIADLKKEIEILRNLYHENIVK-YKGICTEDGGNGIKLIMEFLPS  949

Query  67    GEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD  125
             G + ++L  +      + + K+  QI   + +   R  VHRDL A N+L+++   +KI D
Sbjct  950   GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD  1009

Query  126   FGFSNLFTPGQ---LLKTWCGSPPY-AAPE-LFEGKEYDGPKVDIWSLGVVLYVLV  176
             FG +      +    +K    SP +  APE L + K Y     D+WS GV L+ L+
Sbjct  1010  FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIAS--DVWSFGVTLHELL  1063


 Score = 53.9 bits (128),  Expect = 4e-07
 Identities = 52/187 (27%), Positives = 81/187 (43%), Gaps = 14/187 (7%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            KV +K++D +  D       F    +M+ + H HI+ LY V   +    +V E+  GG +
Sbjct  606  KVILKVLDPSHRDIS--LAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPL  663

Query  70   FDHLVAHGRMAEKEARRKF---KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF  126
               L  H +        KF   KQ+ +A+ +   +++VH ++  +NLLL A   I     
Sbjct  664  --DLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL-AREGIDSECG  720

Query  127  GFSNLFTPG----QLLKTWC-GSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGAL  180
             F  L  PG     L +  C    P+ APE  E  +      D WS G  L+ +   G +
Sbjct  721  PFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEI  780

Query  181  PFDGSTL  187
            P    TL
Sbjct  781  PLKDKTL  787


>gi|82582303|sp|Q59H18|TNI3K_HUMAN  Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase) 
(Cardiac ankyrin repeat kinase)
Length=936

 Score = 58.5 bits (140),  Expect = 2e-08
 Identities = 44/170 (25%), Positives = 80/170 (47%), Gaps = 6/170 (3%)

Query  19   TQLDEENLKKIFREVQIMKMLCHPHIIRLYQV-METERMIYLVTEYASGGEIFDHLVAHG  77
            T   + ++    REV I+  L HP +I+     +       +VT+Y SGG +F  L    
Sbjct  597  TYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK  656

Query  78   RMAEKEARRKFK-QIVTAVYFCH--CRNIVHRDLKAENLLLDANLNIKIADFGFSNLF--  132
            R+ + +++      +   + + H   + I+HRDL + N+LL  + +  +ADFG S     
Sbjct  657  RILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQS  716

Query  133  TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
                 +    G+  + APE+F        K D++S  + L+ ++ G +PF
Sbjct  717  LDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPF  766


>gi|464868|sp|Q02763|TIE2_HUMAN  Angiopoietin-1 receptor precursor (Tyrosine-protein kinase receptor 
TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) 
(p140 TEK) (Tunica interna endothelial cell kinase) (CD202b 
antigen)
Length=1124

 Score = 58.2 bits (139),  Expect = 2e-08
 Identities = 53/187 (28%), Positives = 81/187 (43%), Gaps = 30/187 (16%)

Query  36    MKMLC----HPHIIRLYQVMETERMIYLVTEYASGGEIFDHL-------------VAHGR  78
             +++LC    HP+II L    E    +YL  EYA  G + D L             +A+  
Sbjct  873   LEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANST  932

Query  79    MAEKEARRKFK---QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPG  135
              +   +++       +   + +   +  +HRDL A N+L+  N   KIADFG S     G
Sbjct  933   ASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR----G  988

Query  136   Q--LLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLV-CGALPFDGSTLQNL  190
             Q   +K   G  P  + A E      Y     D+WS GV+L+ +V  G  P+ G T   L
Sbjct  989   QEVYVKKTMGRLPVRWMAIESLNYSVYT-TNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL  1047

Query  191   RARVLSG  197
               ++  G
Sbjct  1048  YEKLPQG  1054


>gi|3183003|sp|Q14289|FAK2_HUMAN  Protein tyrosine kinase 2 beta (Focal adhesion kinase 2) (FADK 
2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase 
beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) 
(Related adhesion focal tyrosine kinase)
Length=1009

 Score = 58.2 bits (139),  Expect = 2e-08
 Identities = 48/176 (27%), Positives = 79/176 (44%), Gaps = 7/176 (3%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K   K     +N +K   E  IMK L HPHI++L  ++E E   +++ E    GE+ 
Sbjct  454  VAVKTCKK-DCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIE-EEPTWIIMELYPYGELG  511

Query  71   DHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
             +L  +    +      +  QI  A+ +    N VHRD+   N+L+ +   +K+ DFG S
Sbjct  512  HYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLS  571

Query  130  NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
                     K      P  + +PE    + +     D+W   V ++ +L  G  PF
Sbjct  572  RYIEDEDYYKASVTRLPIKWMSPESINFRRFTTAS-DVWMFAVCMWEILSFGKQPF  626


>gi|34222653|sp|Q9NSY1|BMP2K_HUMAN  BMP-2-inducible protein kinase (BIKe)
Length=1161

 Score = 58.2 bits (139),  Expect = 2e-08
 Identities = 64/216 (29%), Positives = 98/216 (45%), Gaps = 32/216 (14%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHII-----RLYQVMETERMIYLVTEY  63
            + A+K +    + + N+ K  RE+ IMK L  H +I+      +  + +    + ++ EY
Sbjct  75   RCALKRMYVNNMPDLNVCK--REITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEY  132

Query  64   ASGGEIFDHL--VAHGRMAEKEARRKFKQIVTAVYFCH-CRN-IVHRDLKAENLLLDANL  119
               G++ + +         E E  + F     AV   H C+  I+HRDLK EN+LL+   
Sbjct  133  CRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGG  192

Query  120  NIKIADFG-----FSNLFTPG-----QLLKTWCGSPPYAAPE---LFEGKEYDGPKVDIW  166
            N  + DFG     F N    G     + +K +  +  Y APE   L+ GK     K DIW
Sbjct  193  NYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT-TLSYRAPEMINLYGGKPIT-TKADIW  250

Query  167  SLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIP  202
            +LG +LY L    LPF  S     +  +  G F IP
Sbjct  251  ALGCLLYKLCFFTLPFGES-----QVAICDGNFTIP  281


>gi|12644000|sp|P14616|INSRR_HUMAN  Insulin receptor-related protein precursor (IRR) (IR-related 
receptor) [Contains: Insulin receptor-related protein alpha 
chain; Insulin receptor-related protein beta chain]
Length=1297

 Score = 57.8 bits (138),  Expect = 3e-08
 Identities = 52/202 (25%), Positives = 93/202 (46%), Gaps = 18/202 (8%)

Query  11    VAIKIIDKTQLDEENLKKIFREVQIMKML-CHPHIIRLYQVMETERMIYLVTEYASGGEI  69
             VA+K +++     E ++   +E  +MK   CH H++RL  V+   +   ++ E  + G++
Sbjct  1010  VALKTVNELASPRECIE-FLKEASVMKAFKCH-HVVRLLGVVSQGQPTLVIMELMTRGDL  1067

Query  70    FDHLVAHGRMAEK----------EARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL  119
               HL +    AE           E  +   +I   + +      VHRDL A N ++  + 
Sbjct  1068  KSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDF  1127

Query  120   NIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
              +KI DFG + +++      K   G  P  + APE  +   +     D+WS GVVL+ +V
Sbjct  1128  TVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFT-THSDVWSFGVVLWEIV  1186

Query  177   CGA-LPFDGSTLQNLRARVLSG  197
               A  P+ G + + +   V+ G
Sbjct  1187  TLAEQPYQGLSNEQVLKFVMDG  1208


>gi|13878706|sp|Q01974|ROR2_HUMAN  Tyrosine-protein kinase transmembrane receptor ROR2 precursor 
(Neurotrophic tyrosine kinase, receptor-related 2)
Length=943

 Score = 57.8 bits (138),  Expect = 3e-08
 Identities = 57/202 (28%), Positives = 95/202 (47%), Gaps = 26/202 (12%)

Query  11   VAIKII-DKTQLDEENLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
            VAIK + DK    E  L++ FR E  +   L HP+++ L  V+  ++ + ++  Y S G+
Sbjct  504  VAIKTLKDKA---EGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGD  560

Query  69   IFDHLVA---HGRMAEKEARRKFK-------------QIVTAVYFCHCRNIVHRDLKAEN  112
            + + LV    H  +   +  R  K             QI   + +    ++VH+DL   N
Sbjct  561  LHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRN  620

Query  113  LLLDANLNIKIADFG-FSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLG  169
            +L+   LN+KI+D G F  ++     +LL        + APE     ++     DIWS G
Sbjct  621  VLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDS-DIWSYG  679

Query  170  VVLY-VLVCGALPFDGSTLQNL  190
            VVL+ V   G  P+ G + Q++
Sbjct  680  VVLWEVFSYGLQPYCGYSNQDV  701


>gi|41017258|sp|Q9UQ07|MOK_HUMAN  MAPK/MAK/MRK overlapping kinase (MOK protein kinase) (Renal tumor 
antigen 1) (RAGE-1)
Length=419

 Score = 57.8 bits (138),  Expect = 3e-08
 Identities = 61/252 (24%), Positives = 114/252 (45%), Gaps = 30/252 (11%)

Query  31   REVQIMKMLC-HPHIIRLYQVMETERM--IYLVTEYASGGEIFDHLVAHGR---MAEKEA  84
            RE+Q ++ L  HP+I+ L++V+   +   + L+ E     ++  + +  GR   ++EK+ 
Sbjct  49   REIQALRRLNPHPNILMLHEVVFDRKSGSLALICELM---DMNIYELIRGRRYPLSEKKI  105

Query  85   RRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS  144
                 Q+  ++   H   I HRD+K EN+L+  ++ +K+ DFG        Q    +  +
Sbjct  106  MHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDV-LKLGDFGSCRSVYSKQPYTEYIST  164

Query  145  PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG-------STLQNL---RARV  194
              Y APE      +   K+D+WS G V Y +      F G       S + ++    A+ 
Sbjct  165  RWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQK  224

Query  195  LSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRL  254
            +  KF+    M+  +    GS   ++       L   CLS      L+  M+  DP++R+
Sbjct  225  ILTKFKQSRAMNFDFPFKKGSGIPLLTT----NLSPQCLS------LLHAMVAYDPDERI  274

Query  255  SMEQICKHKWMK  266
            +  Q  +H + +
Sbjct  275  AAHQALQHPYFQ  286


>gi|33112647|sp|P06213|INSR_HUMAN  Insulin receptor precursor (IR) (CD220 antigen) [Contains: Insulin 
receptor alpha subunit; Insulin receptor beta subunit]
Length=1382

 Score = 57.8 bits (138),  Expect = 3e-08
 Identities = 51/205 (24%), Positives = 97/205 (47%), Gaps = 18/205 (8%)

Query  10    KVAIKIIDKTQLDEENLKKIFREVQIMK-MLCHPHIIRLYQVMETERMIYLVTEYASGGE  68
             +VA+K ++++    E ++    E  +MK   CH H++RL  V+   +   +V E  + G+
Sbjct  1053  RVAVKTVNESASLRERIE-FLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGD  1110

Query  69    IFDHLVAHGRMAE----------KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN  118
             +  +L +    AE          +E  +   +I   + + + +  VHRDL A N ++  +
Sbjct  1111  LKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD  1170

Query  119   LNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVL  175
               +KI DFG + +++      K   G  P  + APE  +   +     D+WS GVVL+ +
Sbjct  1171  FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFT-TSSDMWSFGVVLWEI  1229

Query  176   VCGA-LPFDGSTLQNLRARVLSGKF  199
                A  P+ G + + +   V+ G +
Sbjct  1230  TSLAEQPYQGLSNEQVLKFVMDGGY  1254


>gi|10719883|sp|P57078|RIPK4_HUMAN  Serine/threonine-protein kinase RIPK4 (Receptor-interacting serine/threonine-protein 
kinase 4) (Ankyrin repeat domain protein 
3) (PKC-delta-interacting protein kinase)
Length=832

 Score = 57.0 bits (136),  Expect = 5e-08
 Identities = 48/195 (24%), Positives = 90/195 (46%), Gaps = 11/195 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            +AIK      +D+    ++  E + M+M    +I+ +Y +      + LV EY   G + 
Sbjct  48   LAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREP--VGLVMEYMETGSL-  104

Query  71   DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKIADFGF  128
            + L+A   +      R   +    + F HC    ++H DLK  N+LLDA+ ++KI+DFG 
Sbjct  105  EKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGL  164

Query  129  SNL----FTPGQLLKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVVLYVLVCGALPF-  182
            +       +    +    G+  Y  PE + E       K D++S  +V++ ++    PF 
Sbjct  165  AKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFA  224

Query  183  DGSTLQNLRARVLSG  197
            D   + ++  +V+ G
Sbjct  225  DEKNILHIMVKVVKG  239


>gi|20455217|sp|O43353|RIPK2_HUMAN  Receptor-interacting serine/threonine-protein kinase 2 (RIP-like-interacting 
CLARP kinase) (Receptor-interacting protein 
2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme-associated 
kinase) (CARD-containing IL-1 beta ICE-kinase)
Length=540

 Score = 57.0 bits (136),  Expect = 5e-08
 Identities = 51/191 (26%), Positives = 82/191 (42%), Gaps = 14/191 (7%)

Query  10   KVAIKIID-KTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG-  67
            +VA+K +   T L +   K + RE +I+      +I+ +  +      + +VTEY   G 
Sbjct  43   QVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGS  102

Query  68   --EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKI  123
              E+      +  +A     R   +I   V + H     ++H DLK +N+LLD   ++KI
Sbjct  103  LNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI  162

Query  124  ADFGFSNLFTPGQLLKTWCGSPP------YAAPELFE--GKEYDGPKVDIWSLGVVLYVL  175
            ADFG S              S P      Y  PE +E   K     K DI+S  V+ + +
Sbjct  163  ADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEV  222

Query  176  VCGALPFDGST  186
            +    PF+  T
Sbjct  223  LSRKQPFEDVT  233


>gi|19924290|sp|Q01973|ROR1_HUMAN  Tyrosine-protein kinase transmembrane receptor ROR1 precursor 
(Neurotrophic tyrosine kinase, receptor-related 1)
Length=937

 Score = 57.0 bits (136),  Expect = 5e-08
 Identities = 51/209 (24%), Positives = 90/209 (43%), Gaps = 23/209 (11%)

Query  3    PTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE  62
            P    A  VAIK + K   + +   +  +E  +M  L HP+I+ L   +  E+ + ++ E
Sbjct  495  PGMDHAQLVAIKTL-KDYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFE  553

Query  63   YASGGEIFDHLVAH------GRMAEKEARRKFK-----------QIVTAVYFCHCRNIVH  105
            Y + G++ + L+        G  ++++   K             QI   + +      VH
Sbjct  554  YINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVH  613

Query  106  RDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS---PPYAAPELFEGKEYDGPK  162
            +DL A N+L+   L++KI+D G S         +    S     +  PE     ++    
Sbjct  614  KDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDS  673

Query  163  VDIWSLGVVLY-VLVCGALPFDGSTLQNL  190
             DIWS GVVL+ +   G  P+ G + Q +
Sbjct  674  -DIWSFGVVLWEIFSFGLQPYYGFSNQEV  701


>gi|125527|sp|P19525|E2AK2_HUMAN  Interferon-induced, double-stranded RNA-activated protein kinase 
(Interferon-inducible RNA-dependent protein kinase) (Protein 
kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein 
kinase)
Length=551

 Score = 57.0 bits (136),  Expect = 5e-08
 Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 5/115 (4%)

Query  88   FKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-SNLFTPGQLLKTWCGSPP  146
            F+QI   V + H + ++HRDLK  N+ L     +KI DFG  ++L   G+  ++  G+  
Sbjct  395  FEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLR  453

Query  147  YAAPELFEGKEYDGPKVDIWSLGVVLYVL--VCGALPFDGSTLQNLRARVLSGKF  199
            Y +PE    ++Y G +VD+++LG++L  L  VC           +LR  ++S  F
Sbjct  454  YMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIF  507


>gi|61213019|sp|Q9P2K8|E2AK4_HUMAN  Eukaryotic translation initiation factor 2-alpha kinase 4 (GCN2-like 
protein)
Length=1649

 Score = 57.0 bits (136),  Expect = 5e-08
 Identities = 45/182 (24%), Positives = 83/182 (45%), Gaps = 25/182 (13%)

Query  19   TQLDEENLKKIFREVQ-------IMKMLCHPHIIRLYQVMETER----MIYLVTEYASGG  67
            T  ++E + K  +++Q        +  L HP+++R   +   E+    ++ ++ E+ SG 
Sbjct  326  TSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGV  385

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
             +  HL   G +   + RR   Q+++ + + H  ++VH+ L A N+L+DA   +KI D+ 
Sbjct  386  SLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYS  445

Query  128  FSNLFTPGQLLKTWCGSPPYAAPEL-FEGKEY---DGPKVDIWSLGVVLYVL----VCGA  179
             S      + L   C    +    + F         G K D+W LG++L  L     CG 
Sbjct  446  IS------KRLADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGE  499

Query  180  LP  181
             P
Sbjct  500  YP  501


 Score = 50.4 bits (119),  Expect = 5e-06
 Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 20/142 (14%)

Query  52   ETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAE  111
            E    +Y+  EY     + D +            R F++I+  + + H + ++HRDLK  
Sbjct  793  EAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPV  852

Query  112  NLLLDANLNIKIADFGFSN---LFT--------PGQLLKT--------WCGSPPYAAPEL  152
            N+ LD++ ++KI DFG +     F+         G L+K+          G+  Y +PE+
Sbjct  853  NIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEV  912

Query  153  -FEGKEYDGPKVDIWSLGVVLY  173
                K     KVD++SLG++ +
Sbjct  913  QGSTKSAYNQKVDLFSLGIIFF  934


>gi|34922255|sp|Q9UQ88|CD2L2_HUMAN  PITSLRE serine/threonine-protein kinase CDC2L2 (Galactosyltransferase-associated 
protein kinase p58/GTA) (Cell division cycle 
2-like protein kinase 2) (CDK11)
Length=780

 Score = 57.0 bits (136),  Expect = 5e-08
 Identities = 71/292 (24%), Positives = 116/292 (39%), Gaps = 22/292 (7%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERM--IYLVTEYASGGEIFDHLVAHGRMAEKEARRKF  88
            RE+  +    HP+I+ + +++    M  IY+V  Y                   E +   
Sbjct  469  REINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLM  528

Query  89   KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCG---SP  145
             Q++  V   H   I+HRDLK  NLLL     +K+ DFG +  +  G  LK +     + 
Sbjct  529  IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY--GSPLKAYTPVVVTQ  586

Query  146  PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFM  205
             Y APEL  G +     VD+WS+G +   L+     F G++  +   +V          +
Sbjct  587  WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKI  646

Query  206  STGYFHL-------LGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ  258
              GY  L          H        + R + G L   +   L+   L   P +R+S E 
Sbjct  647  WPGYSELPVVKKMTFSEH-----PYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAED  701

Query  259  ICKHKWMKLG--DADPN-FDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD  307
              KH++ +      DP+ F    A+ +Q + +R   P   +  L    +G D
Sbjct  702  GLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDD  753


>gi|34978359|sp|P21127|CD2L1_HUMAN  PITSLRE serine/threonine-protein kinase CDC2L1 (Galactosyltransferase-associated 
protein kinase p58/GTA) (Cell division cycle 
2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1)
Length=795

 Score = 56.6 bits (135),  Expect = 7e-08
 Identities = 70/287 (24%), Positives = 114/287 (39%), Gaps = 12/287 (4%)

Query  31   REVQIMKMLCHPHIIRLYQVMETERM--IYLVTEYASGGEIFDHLVAHGRMAEKEARRKF  88
            RE+  +    HP+I+ + +++    M  IY+V  Y                   E +   
Sbjct  484  REINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLM  543

Query  89   KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCG---SP  145
             Q++  V   H   I+HRDLK  NLLL     +K+ DFG +  +  G  LK +     + 
Sbjct  544  IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY--GSPLKAYTPVVVTL  601

Query  146  PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFM  205
             Y APEL  G +     VD+WS+G +   L+     F G +  +   +V          +
Sbjct  602  WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI  661

Query  206  STGYFHLLGSHCNVVLN--AKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHK  263
              GY  L              + R + G L   +   L+   L   P +R+S E   KH+
Sbjct  662  WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHE  721

Query  264  WMKLG--DADPN-FDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD  307
            + +      DP+ F    A+ +Q + +R   P   +  L    +G D
Sbjct  722  YFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDD  768


>gi|2851601|sp|P04629|NTRK1_HUMAN  High affinity nerve growth factor receptor precursor (Neurotrophic 
tyrosine kinase receptor type 1) (TRK1 transforming tyrosine 
kinase protein) (p140-TrkA) (Trk-A)
Length=796

 Score = 56.2 bits (134),  Expect = 9e-08
 Identities = 49/182 (26%), Positives = 84/182 (46%), Gaps = 23/182 (12%)

Query  11   VAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            VA+K + +     E+ ++ F RE +++ ML H HI+R + V    R + +V EY   G++
Sbjct  541  VAVKALKEAS---ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDL  597

Query  70   FDHLVAHGRMAEKEARRK---------------FKQIVTAVYFCHCRNIVHRDLKAENLL  114
               L +HG  A+  A  +                 Q+   + +    + VHRDL   N L
Sbjct  598  NRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCL  657

Query  115  LDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVV  171
            +   L +KI DFG S ++++            P  +  PE    +++   + D+WS GVV
Sbjct  658  VGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFT-TESDVWSFGVV  716

Query  172  LY  173
            L+
Sbjct  717  LW  718


>gi|6686295|sp|Q02779|M3K10_HUMAN  Mitogen-activated protein kinase kinase kinase 10 (Mixed lineage 
kinase 2) (Protein kinase MST)
Length=954

 Score = 55.1 bits (131),  Expect = 2e-07
 Identities = 49/186 (26%), Positives = 87/186 (46%), Gaps = 16/186 (8%)

Query  10   KVAIKI--IDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG  67
            +VA+K   +D  +      +++ +E ++   L HP+II L         + LV EYA GG
Sbjct  121  EVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGG  180

Query  68   EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR---NIVHRDLKAENLLL--------D  116
             +   ++A  R+          Q+   + + H      I+HRDLK+ N+L+         
Sbjct  181  AL-SRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNL  239

Query  117  ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
            A+  +KI DFG +  +     +    G+  + APE+     +     D+WS GV+L+ L+
Sbjct  240  ADTVLKITDFGLAREWHKTTKMSA-AGTYAWMAPEVIRLSLF-SKSSDVWSFGVLLWELL  297

Query  177  CGALPF  182
             G +P+
Sbjct  298  TGEVPY  303


>gi|68566308|sp|Q9NR20|DYRK4_HUMAN  Dual specificity tyrosine-phosphorylation regulated kinase 4
Length=520

 Score = 54.7 bits (130),  Expect = 3e-07
 Identities = 55/199 (27%), Positives = 84/199 (42%), Gaps = 24/199 (12%)

Query  85   RRKFKQIVTAVYFCHCRNIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLLKTWC  142
            RR    ++  +       I+H DLK EN++L      ++K+ DFG S      Q + T+ 
Sbjct  208  RRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSS--CYEHQKVYTYI  265

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIP  202
             S  Y +PE+  G  YD   +D+WSLG +   L  G   F G       A ++      P
Sbjct  266  QSRFYRSPEVILGHPYD-VAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPP  324

Query  203  F-FMSTG-----YFHLLGSHCNVVLNAKDKR----------LKAGCLSIAECEHLIRHML  246
              F+ T      +F   G   N+  N   KR          LK    S  +    +R  L
Sbjct  325  AGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLD---FLRRCL  381

Query  247  VLDPNKRLSMEQICKHKWM  265
            V +P+ R++ +Q  KH W+
Sbjct  382  VWEPSLRMTPDQALKHAWI  400


>gi|125497|sp|P00540|MOS_HUMAN  Proto-oncogene serine/threonine-protein kinase mos (c-mos) (Oocyte 
maturation factor mos)
Length=346

 Score = 54.7 bits (130),  Expect = 3e-07
 Identities = 43/147 (29%), Positives = 66/147 (44%), Gaps = 11/147 (7%)

Query  55   RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL  114
            ++IY    +  G     H    G+++  +  +    +V  + F H ++IVH DLK  N+L
Sbjct  149  QVIYGAAGHPEGDAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANIL  208

Query  115  LDANLNIKIADFGFSNLF-------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS  167
            +      KI+DFG S          TP   L    G+  + APEL +G E   PK DI+S
Sbjct  209  ISEQDVCKISDFGCSEKLEDLLCFQTPSYPLG---GTYTHRAPELLKG-EGVTPKADIYS  264

Query  168  LGVVLYVLVCGALPFDGSTLQNLRARV  194
              + L+ +     P+ G     L A V
Sbjct  265  FAITLWQMTTKQAPYSGERQHILYAVV  291


>gi|48429194|sp|P30530|UFO_HUMAN  Tyrosine-protein kinase receptor UFO precursor (AXL oncogene)
Length=887

 Score = 54.7 bits (130),  Expect = 3e-07
 Identities = 46/195 (23%), Positives = 88/195 (45%), Gaps = 25/195 (12%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQV--METERMIY----LVTEY  63
            KVA+K +         L+    E   MK   HP+++RL  V    +ER  +    ++  +
Sbjct  556  KVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPF  615

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIV-------TAVYFCHCRNIVHRDLKAENLLLD  116
               G++   L+ + R+ ++      + +V       + + +   +  +HRDL A N +L+
Sbjct  616  MKHGDLHSFLL-YSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN  674

Query  117  ANLNIKIADFGFS------NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV  170
             N+++ +ADFG S      + +  G++ K       + A E    + Y   K D+WS GV
Sbjct  675  ENMSVCVADFGLSKKIYNGDYYRQGRIAKM---PVKWIAIESLADRVYTS-KSDVWSFGV  730

Query  171  VLY-VLVCGALPFDG  184
             ++ +   G  P+ G
Sbjct  731  TMWEIATRGQTPYPG  745


>gi|51315812|sp|O75460|ERN1_HUMAN  Serine/threonine-protein kinase/endoribonuclease IRE1 precursor 
(Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) 
(Endoplasmic reticulum-to-nucleus signaling 1) [Includes: 
Serine/threonine-protein kinase ; Endoribonuclease ]
Length=977

 Score = 54.3 bits (129),  Expect = 3e-07
 Identities = 65/247 (26%), Positives = 99/247 (40%), Gaps = 43/247 (17%)

Query  31   REVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEK--EARRK  87
            REVQ+++    HP++IR +   +  +  Y+  E  +        V     A    E    
Sbjct  611  REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA--TLQEYVEQKDFAHLGLEPITL  668

Query  88   FKQIVTAVYFCHCRNIVHRDLKAENLLLD-----ANLNIKIADFGFSNLFTPGQ----LL  138
             +Q  + +   H  NIVHRDLK  N+L+        +   I+DFG       G+      
Sbjct  669  LQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRR  728

Query  139  KTWCGSPPYAAPELF--EGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGSTLQNLRARVL  195
                G+  + APE+   + KE     VDI+S G V Y +V  G+ PF G +LQ  +A +L
Sbjct  729  SGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVVSEGSHPF-GKSLQR-QANIL  786

Query  196  SGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS  255
             G   +              H +V+                    LI  M+ +DP KR S
Sbjct  787  LGACSLDCLHPE-------KHEDVI-----------------ARELIEKMIAMDPQKRPS  822

Query  256  MEQICKH  262
               + KH
Sbjct  823  ANDVLKH  829


>gi|18203329|sp|Q9NZJ5|E2AK3_HUMAN  Eukaryotic translation initiation factor 2-alpha kinase 3 precursor 
(PRKR-like endoplasmic reticulum kinase) (Pancreatic 
eIF2-alpha kinase) (HsPEK)
Length=1115

 Score = 54.3 bits (129),  Expect = 3e-07
 Identities = 37/119 (31%), Positives = 55/119 (46%), Gaps = 19/119 (15%)

Query  76    HGRMAEKEARRK-----FKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  130
             +GR   +E  R      F QI  AV F H + ++HRDLK  N+    +  +K+ DFG   
Sbjct  900   NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT  959

Query  131   LFTPGQLLKT-------------WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
                  +  +T               G+  Y +PE   G  Y   KVDI+SLG++L+ L+
Sbjct  960   AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSY-SHKVDIFSLGLILFELL  1017


>gi|125484|sp|P08581|MET_HUMAN  Hepatocyte growth factor receptor precursor (Met proto-oncogene 
tyrosine kinase) (c-met) (HGF receptor) (HGF-SF receptor)
Length=1390

 Score = 54.3 bits (129),  Expect = 3e-07
 Identities = 51/196 (26%), Positives = 89/196 (45%), Gaps = 12/196 (6%)

Query  12    AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQV-METERMIYLVTEYASGGEI-  69
             A+K +++   D   + +   E  IMK   HP+++ L  + + +E    +V  Y   G++ 
Sbjct  1108  AVKSLNRIT-DIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLR  1166

Query  70    -FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF  128
              F     H     K+      Q+   + +   +  VHRDL A N +LD    +K+ADFG 
Sbjct  1167  NFIRNETHNPTV-KDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGL  1225

Query  129   SNLFTPGQLL----KTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPF  182
             +      +      KT    P  + A E  + +++   K D+WS GVVL+ L+  GA P+
Sbjct  1226  ARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFT-TKSDVWSFGVVLWELMTRGAPPY  1284

Query  183   DGSTLQNLRARVLSGK  198
                   ++   +L G+
Sbjct  1285  PDVNTFDITVYLLQGR  1300


>gi|56749062|sp|Q6VAB6|KSR2_HUMAN  Kinase suppressor of ras-2 (hKSR2)
Length=829

 Score = 54.3 bits (129),  Expect = 3e-07
 Identities = 47/189 (24%), Positives = 88/189 (46%), Gaps = 18/189 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAI++ID  + +E+ LK   REV   +   H +++       +   + ++T    G  +
Sbjct  567  EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTL  626

Query  70   FDHLVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG  127
            +  +V   ++     + R+  ++IV  + + H + I+H+DLK++N+  D N  + I DFG
Sbjct  627  YS-VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFG  684

Query  128  ---FSNLFTPGQ---LLKTWCGSPPYAAPELF--------EGKEYDGPKVDIWSLGVVLY  173
                S +   G+    L+   G   + APE+         E K       D+++LG + Y
Sbjct  685  LFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWY  744

Query  174  VLVCGALPF  182
             L     PF
Sbjct  745  ELHAREWPF  753


>gi|13626369|sp|O43781|DYRK3_HUMAN  Dual specificity tyrosine-phosphorylation regulated kinase 3
Length=588

 Score = 54.3 bits (129),  Expect = 3e-07
 Identities = 58/216 (26%), Positives = 90/216 (41%), Gaps = 42/216 (19%)

Query  86   RKFKQ-IVTAVYFCHCRNIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLLKTWC  142
            RKF Q I+ ++   H   I+H DLK EN+LL      + K+ DFG S      Q L T+ 
Sbjct  313  RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYI  370

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRA----------  192
             S  Y APE+  G  Y  P +DIWS   +L  L+ G   F G    +  A          
Sbjct  371  QSRFYRAPEIILGSRYSTP-IDIWSFRCILAELLTGQPLFPGEDEGDQLACMMELLGMPP  429

Query  193  -RVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLS-----------------  234
             ++L    R  +F+++     +  +C+V   A  + +  G  S                 
Sbjct  430  PKLLEQSKRAKYFINS---KGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA  486

Query  235  IAECE-----HLIRHMLVLDPNKRLSMEQICKHKWM  265
            +  C+       ++  L  DP+ RL+  Q  +H W+
Sbjct  487  LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI  522


>gi|24638466|sp|P46734|MP2K3_HUMAN  Dual specificity mitogen-activated protein kinase kinase 3 (MAP 
kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3)
Length=347

 Score = 53.5 bits (127),  Expect = 6e-07
 Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 6/118 (5%)

Query  91   IVTAVYFCHCR-NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAA  149
            IV A+   H + +++HRD+K  N+L++   ++K+ DFG S             G  PY A
Sbjct  173  IVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMA  232

Query  150  PELFE---GKEYDGPKVDIWSLGVVLYVLVCGALPFD--GSTLQNLRARVLSGKFRIP  202
            PE       ++    K D+WSLG+ +  +     P++  G+  Q L+  V     ++P
Sbjct  233  PERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLP  290


>gi|46577677|sp|O75716|STK16_HUMAN  Serine/threonine-protein kinase 16 (Protein kinase PKL12) (Myristoylated 
and palmitoylated serine/threonine-protein kinase) 
(MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK)
Length=305

 Score = 53.1 bits (126),  Expect = 8e-07
 Identities = 47/182 (25%), Positives = 79/182 (43%), Gaps = 20/182 (10%)

Query  22   DEENLKKIFREVQIMKMLCHPHIIRLYQVMETER----MIYLVTEYASGGEIF---DHLV  74
            ++++ ++  RE  + ++  HP+I+RL      ER      +L+  +   G ++   + L 
Sbjct  55   EQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLK  114

Query  75   AHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN---  130
              G  + E +       I   +   H +   HRDLK  N+LL       + D G  N   
Sbjct  115  DKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQAC  174

Query  131  LFTPGQ----LLKTWCGSP---PYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALP  181
            +   G      L+ W        Y APELF  + +     + D+WSLG VLY ++ G  P
Sbjct  175  IHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGP  234

Query  182  FD  183
            +D
Sbjct  235  YD  236


>gi|1705918|sp|P49759|CLK1_HUMAN  Dual specificity protein kinase CLK1 (CDC-like kinase 1)
Length=484

 Score = 52.8 bits (125),  Expect = 1e-06
 Identities = 73/298 (24%), Positives = 117/298 (39%), Gaps = 58/298 (19%)

Query  8    AAKVAIKIIDKTQLDEENLKKIFREVQIMKML-CHPHIIRLYQVMETERMIYLVTEYASG  66
            AA+  I++++     + N    FR VQ+++    H HI  +++++              G
Sbjct  202  AARSEIQVLEHLNTTDPN--STFRCVQMLEWFEHHGHICIVFELL--------------G  245

Query  67   GEIFDHLVAHGRMAEK--EARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD--------  116
               +D +  +G +  +    R+   QI  +V F H   + H DLK EN+L          
Sbjct  246  LSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAY  305

Query  117  -----------ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDI  165
                        N +IK+ DFG +      +   T   +  Y APE+     +  P  D+
Sbjct  306  NPKIKRDERTLINPDIKVVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQP-CDV  362

Query  166  WSLGVVLYVLVCGALPF---DGSTLQNLRARVLS--GKFRIPFFMSTGYFHL------LG  214
            WS+G +L     G   F   D      +  R+L    K  I       YFH         
Sbjct  363  WSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEH  422

Query  215  SHCNVVLNAKDKRLKAGCLSIAECEH-----LIRHMLVLDPNKRLSMEQICKHKWMKL  267
            S     ++   K LK   LS  + EH     LI+ ML  DP KR+++ +  KH +  L
Sbjct  423  SSAGRYVSRACKPLKEFMLS-QDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL  479


>gi|13626380|sp|Q92630|DYRK2_HUMAN  Dual specificity tyrosine-phosphorylation regulated kinase 2
Length=528

 Score = 52.4 bits (124),  Expect = 1e-06
 Identities = 38/96 (39%), Positives = 50/96 (52%), Gaps = 6/96 (6%)

Query  86   RKFKQ-IVTAVYFCHCRNIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLLKTWC  142
            RKF   I+  +   H   I+H DLK EN+LL       IK+ DFG S      Q + T+ 
Sbjct  253  RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--CYEHQRVYTYI  310

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
             S  Y APE+  G  Y G  +D+WSLG +L  L+ G
Sbjct  311  QSRFYRAPEVILGARY-GMPIDMWSLGCILAELLTG  345


>gi|9296963|sp|Q9Y463|DYR1B_HUMAN  Dual specificity tyrosine-phosphorylation regulated kinase 1B 
(Mirk protein kinase) (Minibrain-related kinase)
Length=629

 Score = 52.4 bits (124),  Expect = 1e-06
 Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 7/105 (6%)

Query  85   RRKFKQIVTAVYFCHCR--NIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLLKT  140
            R+  +Q+ TA+ F      +I+H DLK EN+LL       IKI DFG S     GQ +  
Sbjct  215  RKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQ  272

Query  141  WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            +  S  Y +PE+  G  YD   +D+WSLG +L  +  G   F GS
Sbjct  273  YIQSRFYRSPEVLLGTPYD-LAIDMWSLGCILVEMHTGEPLFSGS  316


>gi|124240|sp|P08069|IGF1R_HUMAN  Insulin-like growth factor 1 receptor precursor (Insulin-like 
growth factor I receptor) (IGF-I receptor) (CD221 antigen) 
[Contains: Insulin-like growth factor 1 receptor alpha chain; 
Insulin-like growth factor 1 receptor beta chain]
Length=1367

 Score = 52.4 bits (124),  Expect = 1e-06
 Identities = 48/203 (23%), Positives = 92/203 (45%), Gaps = 18/203 (8%)

Query  10    KVAIKIIDKTQLDEENLKKIFREVQIMKML-CHPHIIRLYQVMETERMIYLVTEYASGGE  68
             +VAIK +++     E ++    E  +MK   CH H++RL  V+   +   ++ E  + G+
Sbjct  1029  RVAIKTVNEAASMRERIE-FLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGD  1086

Query  69    IFDHL------VAHGRMAEKEARRKFKQ----IVTAVYFCHCRNIVHRDLKAENLLLDAN  118
             +  +L      + +  +    +  K  Q    I   + + +    VHRDL A N ++  +
Sbjct  1087  LKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAED  1146

Query  119   LNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-V  174
               +KI DFG + +++      K   G  P  + +PE  +   +     D+WS GVVL+ +
Sbjct  1147  FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFT-TYSDVWSFGVVLWEI  1205

Query  175   LVCGALPFDGSTLQNLRARVLSG  197
                   P+ G + + +   V+ G
Sbjct  1206  ATLAEQPYQGLSNEQVLRFVMEG  1228


>gi|20532386|sp|Q13705|AVR2B_HUMAN  Activin receptor type 2B precursor (Activin receptor type IIB) 
(ACTR-IIB)
Length=512

 Score = 52.4 bits (124),  Expect = 1e-06
 Identities = 47/158 (29%), Positives = 74/158 (46%), Gaps = 28/158 (17%)

Query  99   HCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL---LKTWCGSPPYAAPELFEG  155
            H  +I HRD K++N+LL ++L   +ADFG +  F PG+         G+  Y APE+ EG
Sbjct  313  HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEG  372

Query  156  K---EYDG-PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFH  211
                + D   ++D++++G+VL+ LV      DG             ++ +PF    G   
Sbjct  373  AINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPV----------DEYMLPFEEEIGQHP  422

Query  212  LLGSHCNVVLN------AKDKRLKAG-----CLSIAEC  238
             L     VV++       KD  LK       C++I EC
Sbjct  423  SLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEEC  460


>gi|125361|sp|P17948|VGFR1_HUMAN  Vascular endothelial growth factor receptor 1 precursor (VEGFR-1) 
(Vascular permeability factor receptor) (Tyrosine-protein 
kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) 
(Fms-like tyrosine kinase 1)
Length=1338

 Score = 51.6 bits (122),  Expect = 2e-06
 Identities = 39/130 (30%), Positives = 63/130 (48%), Gaps = 7/130 (5%)

Query  90    QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN--LFTPGQLLKTWCGSP-P  146
             Q+   + F   R  +HRDL A N+LL  N  +KI DFG +      P  + K     P  
Sbjct  1005  QVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLK  1064

Query  147   YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTL-QNLRARVLSG-KFRIPF  203
             + APE    K Y   K D+WS GV+L+ +   G  P+ G  + ++  +R+  G + R P 
Sbjct  1065  WMAPESIFDKIY-STKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPE  1123

Query  204   FMSTGYFHLL  213
             + +   + ++
Sbjct  1124  YSTPEIYQIM  1133


>gi|6919882|sp|O15197|EPHB6_HUMAN  Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective 
receptor EPH-6) (HEP)
Length=1006

 Score = 51.6 bits (122),  Expect = 2e-06
 Identities = 45/165 (27%), Positives = 83/165 (50%), Gaps = 14/165 (8%)

Query  41   HPHIIRLYQVMETERMIYLVTEYASGGEIFDHL-VAHGRMAEKEARRKFKQIVTAVYFCH  99
            HP+I+RL  V+   R + ++TE+   G +   L    G+ +  +     + +  A+ +  
Sbjct  713  HPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLS  772

Query  100  CRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD  159
                VHR L A ++L++++L  K+A  G S    P  LL+       +AAPE+    ++ 
Sbjct  773  SFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQ-GPSCLLR-------WAAPEVIAHGKHT  824

Query  160  GPKVDIWSLGVVLY-VLVCGALPF-DGSTLQNLRARVLSGKFRIP  202
                D+WS G++++ V+  G  P+ D S  + L A  +  +FR+P
Sbjct  825  -TSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNA--IEQEFRLP  866


>gi|8134650|sp|Q13308|PTK7_HUMAN  Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 
4) (CCK-4)
Length=1070

 Score = 51.6 bits (122),  Expect = 2e-06
 Identities = 43/194 (22%), Positives = 79/194 (40%), Gaps = 15/194 (7%)

Query  22    DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF---------DH  72
             DE+      RE+++   L H +++RL  +       Y+V EY    ++          D 
Sbjct  836   DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLEDLKQFLRISKSKDE  895

Query  73    LVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF  132
              +    ++ K+      Q+   +        VH+DL A N L+ A   +K++  G S   
Sbjct  896   KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV  955

Query  133   TPGQ---LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQ  188
                +     + W      +   + EG      K D+W+ GV+++ V   G +P  G    
Sbjct  956   YNSEYYHFRQAWVALRWMSPEAILEGD--FSTKSDVWASGVLMWEVFTHGEMPHGGQADD  1013

Query  189   NLRARVLSGKFRIP  202
              + A + +GK R+P
Sbjct  1014  EVLADLQAGKARLP  1027


>gi|62901083|sp|Q6J9G0|STYK1_HUMAN  Tyrosine protein-kinase STYK1 (Serine/threonine/tyrosine kinase 
1) (Novel oncogene with kinase-domain) (Protein PK-unique)
Length=422

 Score = 51.6 bits (122),  Expect = 2e-06
 Identities = 42/170 (24%), Positives = 81/170 (47%), Gaps = 18/170 (10%)

Query  41   HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-----------MAEKEARRKFK  89
            H ++++L      +  +Y+V E  + G++   L    R           + EK+     K
Sbjct  174  HKNLVQLEGCCTEKLPLYVVLEDVAQGDLLGFLWTCRRDVMTMDGLLYDLTEKQVYHIGK  233

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPPYA  148
            Q++ A+ F   +++ H D+ A N+L+ ++L  K+   G +  ++T G +  T      + 
Sbjct  234  QVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWL  293

Query  149  APELFEGKEYDGPKVDIWSLGVVLYVLV-CGALPF----DGSTLQNLRAR  193
            APE    +     + D+WS G++LY +V  GA P+      S L++L+ R
Sbjct  294  APERLLLRP-ARIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRR  342


>gi|61252444|sp|P36894|BMR1A_HUMAN  Bone morphogenetic protein receptor type IA precursor (Serine/threonine-protein 
kinase receptor R5) (SKR5) (Activin receptor-like 
kinase 3) (ALK-3) (CD292 antigen)
Length=532

 Score = 51.2 bits (121),  Expect = 3e-06
 Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 36/191 (18%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMK--MLCHPHIIRLYQV----METERMIYLVTEY  63
            KVA+K+   T+         FRE +I +  ++ H +I+           +   +YL+T+Y
Sbjct  257  KVAVKVFFTTEE-----ASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY  311

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVY-FCHCRN----------IVHRDLKAEN  112
               G ++D L    + A  + R   K   +A    CH             I HRDLK++N
Sbjct  312  HENGSLYDFL----KCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKN  367

Query  113  LLLDANLNIKIADFGFSNLFTPGQ-----LLKTWCGSPPYAAPELFE---GKEYDGPKV-  163
            +L+  N +  IAD G +  F          L T  G+  Y APE+ +    K +  P + 
Sbjct  368  ILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIM  427

Query  164  -DIWSLGVVLY  173
             DI+S G++++
Sbjct  428  ADIYSFGLIIW  438


>gi|3219996|sp|Q13627|DYR1A_HUMAN  Dual specificity tyrosine-phosphorylation regulated kinase 1A 
(Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity 
YAK1-related kinase)
Length=763

 Score = 51.2 bits (121),  Expect = 3e-06
 Identities = 41/105 (39%), Positives = 56/105 (53%), Gaps = 8/105 (7%)

Query  86   RKF-KQIVTAVYFCHCR--NIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLLKT  140
            RKF +Q+ TA+ F      +I+H DLK EN+LL       IKI DFG S     GQ +  
Sbjct  263  RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQ  320

Query  141  WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            +  S  Y +PE+  G  YD   +D+WSLG +L  +  G   F G+
Sbjct  321  YIQSRFYRSPEVLLGMPYD-LAIDMWSLGCILVEMHTGEPLFSGA  364


>gi|56749095|sp|Q8IVT5|KSR1_HUMAN  Kinase suppressor of ras-1 (Kinase suppressor of ras)
Length=921

 Score = 51.2 bits (121),  Expect = 3e-06
 Identities = 42/181 (23%), Positives = 80/181 (44%), Gaps = 16/181 (8%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            +VAI++++    ++++LK   +EV   +   H +++           + ++T +  G  +
Sbjct  633  EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTL  692

Query  70   FDHLVAHGRMAEKEARRKFKQ-IVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD---  125
               +       +    R+  Q I+  + + H + IVH+DLK++N+  D N  + I D   
Sbjct  693  HSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYD-NGKVVITDFGL  751

Query  126  FGFSNLFTPG------QLLKTW-CGSPPYAAPELFEGKEYD----GPKVDIWSLGVVLYV  174
            FG S +   G      +L   W C   P    E+  GK+ D        D+++ G V Y 
Sbjct  752  FGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYE  811

Query  175  L  175
            L
Sbjct  812  L  812


>gi|585912|sp|Q04912|RON_HUMAN  Macrophage-stimulating protein receptor precursor (MSP receptor) 
(p185-Ron) (CDW136) (CD136 antigen) [Contains: Macrophage-stimulating 
protein receptor alpha chain; Macrophage-stimulating 
protein receptor beta chain]
Length=1400

 Score = 50.8 bits (120),  Expect = 4e-06
 Identities = 44/179 (24%), Positives = 83/179 (46%), Gaps = 10/179 (5%)

Query  12    AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM-ETERMIYLVTEYASGGEIF  70
             AIK + +   + + ++   RE  +M+ L HP+++ L  +M   E + +++  Y   G++ 
Sbjct  1112  AIKSLSRIT-EMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLL  1170

Query  71    DHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS  129
               + +  R    +    F  Q+   + +   +  VHRDL A N +LD +  +K+ADFG +
Sbjct  1171  QFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLA  1230

Query  130   NLFTPGQLLKTWCG-----SPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
                   +               + A E  +   +   K D+WS GV+L+ +L  GA P+
Sbjct  1231  RDILDREYYSVQQHRHARLPVKWMALESLQTYRFT-TKSDVWSFGVLLWELLTRGAPPY  1288


>gi|2506798|sp|P08922|ROS_HUMAN  Proto-oncogene tyrosine-protein kinase ROS precursor (c-ros-1)
Length=2347

 Score = 50.8 bits (120),  Expect = 4e-06
 Identities = 51/193 (26%), Positives = 85/193 (44%), Gaps = 26/193 (13%)

Query  10    KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
             KVA+K + K   D+E ++   +E  +M    HP+I++   V       Y++ E   GG++
Sbjct  1976  KVAVKTLKKGSTDQEKIE-FLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDL  2034

Query  70    FDHLVAHGRMAEKEARRKFKQIVTAVYFC----------HCRNIVHRDLKAENLLLDAN-  118
               +L    RMA          +V  V  C             + +HRDL A N L+    
Sbjct  2035  LTYL-RKARMATFYG--PLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKD  2091

Query  119   ----LNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPE-LFEGKEYDGPKVDIWSLGV  170
                   +KI DFG + +++      K   G  P  + APE L +G      + D+WS G+
Sbjct  2092  YTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDG--IFTTQSDVWSFGI  2149

Query  171   VLY-VLVCGALPF  182
             +++ +L  G  P+
Sbjct  2150  LIWEILTLGHQPY  2162


>gi|50400806|sp|O15146|MUSK_HUMAN  Muscle, skeletal receptor tyrosine protein kinase precursor (Muscle-specific 
tyrosine protein kinase receptor) (Muscle-specific 
kinase receptor) (MuSK)
Length=869

 Score = 50.8 bits (120),  Expect = 4e-06
 Identities = 49/202 (24%), Positives = 89/202 (44%), Gaps = 30/202 (14%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K++ K +   +      RE  +M    +P+I++L  V    + + L+ EY + G++ 
Sbjct  606  VAVKML-KEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLN  664

Query  71   DHL----------VAHGRMAEK--------------EARRKFKQIVTAVYFCHCRNIVHR  106
            + L          ++H  ++ +              E     +Q+   + +   R  VHR
Sbjct  665  EFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHR  724

Query  107  DLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKV  163
            DL   N L+  N+ +KIADFG S N+++          + P  +  PE      Y   + 
Sbjct  725  DLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYT-TES  783

Query  164  DIWSLGVVLY-VLVCGALPFDG  184
            D+W+ GVVL+ +   G  P+ G
Sbjct  784  DVWAYGVVLWEIFSYGLQPYYG  805


>gi|10720097|sp|Q12866|MERTK_HUMAN  Proto-oncogene tyrosine-protein kinase MER precursor (C-mer) 
(Receptor tyrosine kinase MerTK)
Length=999

 Score = 50.4 bits (119),  Expect = 5e-06
 Identities = 47/194 (24%), Positives = 87/194 (44%), Gaps = 24/194 (12%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQV---METERMI--YLVTEYA  64
            KVA+K +         +++   E   MK   HP++IRL  V   M ++ +    ++  + 
Sbjct  615  KVAVKTMKLDNSSHREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFM  674

Query  65   SGGEIFDHLVAHGRMAEK------EARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDA  117
              G++  +L+ + R+         +   KF   I   + +   RN +HRDL A N +L  
Sbjct  675  KYGDLHTYLL-YSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD  733

Query  118  NLNIKIADFGFS------NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV  171
            ++ + +ADFG S      + +  G++ K       + A E    + Y   K D+W+ GV 
Sbjct  734  DMTVCVADFGLSKKIYSGDYYRQGRIAKM---PVKWIAIESLADRVYTS-KSDVWAFGVT  789

Query  172  LY-VLVCGALPFDG  184
            ++ +   G  P+ G
Sbjct  790  MWEIRTRGMTPYPG  803


>gi|114722|sp|P27037|AVR2A_HUMAN  Activin receptor type 2A precursor (Activin receptor type IIA) 
(ACTR-IIA) (ACTRIIA)
Length=513

 Score = 50.1 bits (118),  Expect = 6e-06
 Identities = 50/186 (26%), Positives = 83/186 (44%), Gaps = 26/186 (13%)

Query  57   IYLVTEYASGGEIFDHLVAHG-------RMAEKEAR--RKFKQIVTAVYFCHCRNIVHRD  107
            ++L+T +   G + D L A+         +AE  AR      + +  +   H   I HRD
Sbjct  263  LWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRD  322

Query  108  LKAENLLLDANLNIKIADFGFSNLFTPGQL---LKTWCGSPPYAAPELFEGK---EYDG-  160
            +K++N+LL  NL   IADFG +  F  G+         G+  Y APE+ EG    + D  
Sbjct  323  IKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAF  382

Query  161  PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVV  220
             ++D++++G+VL+ L       DG             ++ +PF    G    L     VV
Sbjct  383  LRIDMYAMGLVLWELASRCTAADGPV----------DEYMLPFEEEIGQHPSLEDMQEVV  432

Query  221  LNAKDK  226
            ++ K +
Sbjct  433  VHKKKR  438


>gi|74762722|sp|Q9C0K7|AL2S2_HUMAN  Serine/threonine-protein kinase ALS2CR2 (Amyotrophic lateral 
sclerosis 2 chromosomal region candidate gene 2 protein) (ILP-interacting 
protein) (CALS-21)
Length=418

 Score = 50.1 bits (118),  Expect = 6e-06
 Identities = 48/208 (23%), Positives = 85/208 (40%), Gaps = 16/208 (7%)

Query  2    TPTFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVT  61
            TPT      V IKI +    +EE LK + + V +     HP+I   + V      +++++
Sbjct  80   TPT---GTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNITTYWTVFTVGSWLWVIS  136

Query  62   ---EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN  118
                Y S  ++       G M+E   R      V  + + H    +HR +KA ++L+  +
Sbjct  137  PFMAYGSASQLLRTYFPEG-MSETLIRNILFGAVRGLNYLHQNGCIHRSIKASHILISGD  195

Query  119  LNIKIADFG-FSNLFTPGQLLKTWCGSP-------PYAAPELFEGKEYD-GPKVDIWSLG  169
              + ++      +L   GQ  +     P       P+ +PEL     +    K DI+S+G
Sbjct  196  GLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQDLHGYNVKSDIYSVG  255

Query  170  VVLYVLVCGALPFDGSTLQNLRARVLSG  197
            +    L  G +PF       +  + L G
Sbjct  256  ITACELASGQVPFQDMHRTQMLLQKLKG  283


>gi|1351419|sp|P30291|WEE1_HUMAN  Wee1-like protein kinase (WEE1hu)
Length=646

 Score = 49.7 bits (117),  Expect = 8e-06
 Identities = 60/267 (22%), Positives = 111/267 (41%), Gaps = 52/267 (19%)

Query  21   LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRM  79
            +DE+N     REV    +L  H H++R +     +  + +  EY +GG + D +  + R+
Sbjct  338  VDEQNA---LREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI  394

Query  80   ----AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA------------------  117
                 E E +    Q+   + + H  ++VH D+K  N+ +                    
Sbjct  395  MSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWAS  454

Query  118  -NLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
              +  KI D G     +  Q+ +   G   + A E+ +      PK DI++L +    +V
Sbjct  455  NKVMFKIGDLGHVTRISSPQVEE---GDSRFLANEVLQENYTHLPKADIFALAL---TVV  508

Query  177  CGA----LPFDGSTLQNLRARVLSGKFRIPFFMSTGYFHLLGSHCNVVLNAKDKRLKAGC  232
            C A    LP +G     +R   L    RIP  +S  +  LL     V+++   +R  +  
Sbjct  509  CAAGAEPLPRNGDQWHEIRQGRLP---RIPQVLSQEFTELL----KVMIHPDPERRPSAM  561

Query  233  LSIAECEHLIRHMLVLDPNKRLSMEQI  259
                    L++H ++L  +++ S EQ+
Sbjct  562  A-------LVKHSVLLSASRK-SAEQL  580


>gi|1718189|sp|P35916|VGFR3_HUMAN  Vascular endothelial growth factor receptor 3 precursor (VEGFR-3) 
(Tyrosine-protein kinase receptor FLT4)
Length=1298

 Score = 49.7 bits (117),  Expect = 8e-06
 Identities = 32/99 (32%), Positives = 51/99 (51%), Gaps = 5/99 (5%)

Query  90    QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--  146
             Q+   + F   R  +HRDL A N+LL  +  +KI DFG + +++     ++      P  
Sbjct  1020  QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLK  1079

Query  147   YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
             + APE    K Y   + D+WS GV+L+ +   GA P+ G
Sbjct  1080  WMAPESIFDKVYT-TQSDVWSFGVLLWEIFSLGASPYPG  1117


>gi|34922132|sp|Q9HAZ1|CLK4_HUMAN  Dual specificity protein kinase CLK4 (CDC-like kinase 4)
Length=481

 Score = 49.7 bits (117),  Expect = 8e-06
 Identities = 68/299 (22%), Positives = 119/299 (39%), Gaps = 54/299 (18%)

Query  5    FQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHP-HIIRLYQVMETERMIYLVTEY  63
            ++ AA+  I++++     + N   +FR VQ+++   H  H+  +++++      ++    
Sbjct  197  YREAARSEIQVLEHLNSTDPN--SVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENS  254

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD-------  116
                +I DH+           R+   QI  ++ F H   + H DLK EN+L         
Sbjct  255  FLPFQI-DHI-----------RQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVK  302

Query  117  ------------ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD  164
                         N +IK+ DFG +      +   T   +  Y APE+     +  P  D
Sbjct  303  YNSKMKRDERTLKNTDIKVVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQP-CD  359

Query  165  IWSLGVVLYVLVCGALPF---DGSTLQNLRARVLS--GKFRIPFFMSTGYFHL------L  213
            +WS+G +L     G   F   D      +  R+L    +  I       YFH        
Sbjct  360  VWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDE  419

Query  214  GSHCNVVLNAKDKRLKAGCLSIAECEH-----LIRHMLVLDPNKRLSMEQICKHKWMKL  267
             S     +  + K LK   L   E EH     L+R ML  DP +R+++++  +H +  L
Sbjct  420  HSSAGRYVRRRCKPLKEFMLCHDE-EHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL  477


>gi|9087218|sp|P35968|VGFR2_HUMAN  Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) 
(Kinase insert domain receptor) (Protein-tyrosine kinase 
receptor Flk-1) (CD309 antigen)
Length=1356

 Score = 48.5 bits (114),  Expect = 2e-05
 Identities = 75/340 (22%), Positives = 130/340 (38%), Gaps = 75/340 (22%)

Query  90    QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--  146
             Q+   + F   R  +HRDL A N+LL     +KI DFG + +++     ++      P  
Sbjct  1011  QVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLK  1070

Query  147   YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRIPFFM  205
             + APE    + Y   + D+WS GV+L+ +   GA P+ G  +     R L    R     
Sbjct  1071  WMAPETIFDRVYT-IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR-----  1124

Query  206   STGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM  265
                            + A D        ++ +C H        +P++R +  ++ +H   
Sbjct  1125  ---------------MRAPDYTTPEMYQTMLDCWH-------GEPSQRPTFSELVEH---  1159

Query  266   KLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDA------  319
              LG+       L A  QQ  ++  V P++E  L   ED GL    +  S   +       
Sbjct  1160  -LGNL------LQANAQQDGKDYIVLPISE-TLSMEEDSGLSLPTSPVSCMEEEEVCDPK  1211

Query  320   --YDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQPDGTLNLDSDEGEEPS  377
               YD+ + I   L +  ++ + + +     +P     +  V + PD      +D G    
Sbjct  1212  FHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLE---EPEVKVIPDDN---QTDSG----  1261

Query  378   PEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNP  417
                           + +A    + +ED  KL P F G+ P
Sbjct  1262  --------------MVLASEELKTLEDRTKLSPSFGGMVP  1287


>gi|51315898|sp|Q76MJ5|ERN2_HUMAN  Serine/threonine-protein kinase/endoribonuclease IRE2 precursor 
(Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) 
(Endoplasmic reticulum-to-nucleus signaling 2) [Includes: 
Serine/threonine-protein kinase ; Endoribonuclease ]
Length=925

 Score = 48.5 bits (114),  Expect = 2e-05
 Identities = 57/209 (27%), Positives = 95/209 (45%), Gaps = 19/209 (9%)

Query  4    TFQFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTE  62
            TF F  +   + +   +L  E    + REVQ+++    HP+++R +      +  Y+  E
Sbjct  532  TFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALE  591

Query  63   Y--ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL-----  115
               AS  E  ++        E E     +Q+++ +   H  +IVHRDLK  N+L+     
Sbjct  592  LCRASLQEYVENPDLDRGGLEPEV--VLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDT  649

Query  116  DANLNIKIADFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEGKEYDGP--KVDIWSLG  169
                 + ++DFG       G+    L     G+  + APEL +    + P   VDI+S G
Sbjct  650  QGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPNSPTSAVDIFSAG  709

Query  170  VVL-YVLVCGALPFDGSTLQNLRARVLSG  197
             V  YVL  G+ PF  S  +  +A +L+G
Sbjct  710  CVFYYVLSGGSHPFGDSLYR--QANILTG  736


>gi|1706243|sp|P51841|GUC2F_HUMAN  Retinal guanylyl cyclase 2 precursor (Guanylate cyclase 2F, retinal) 
(RETGC-2) (Rod outer segment membrane guanylate cyclase 
2) (ROS-GC2) (Guanylate cyclase F) (GC-F)
Length=1108

 Score = 48.1 bits (113),  Expect = 2e-05
 Identities = 39/175 (22%), Positives = 76/175 (43%), Gaps = 9/175 (5%)

Query  34   QIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK-QIV  92
            ++MK L H +I  L        M  +VTE+ S G + D L       +   +      ++
Sbjct  596  EMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLI  655

Query  93   TAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPP--YAAP  150
              + + H R  VH  LK+ N ++D    +K+ D+GF+++    +L +         + AP
Sbjct  656  KGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAP  715

Query  151  ELF---EGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIP  202
            EL     G        D++S  +++  ++    PF    + +L A+ +  + + P
Sbjct  716  ELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPF---CMMDLPAQEIINRLKKP  767


>gi|20137251|sp|Q9UM73|ALK_HUMAN  ALK tyrosine kinase receptor precursor (Anaplastic lymphoma kinase) 
(CD246 antigen)
Length=1620

 Score = 47.0 bits (110),  Expect = 5e-05
 Identities = 47/202 (23%), Positives = 84/202 (41%), Gaps = 16/202 (7%)

Query  10    KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
             +VA+K + +   +++ L  +  E  I+    H +I+R   V       +++ E  +GG++
Sbjct  1146  QVAVKTLPEVCSEQDELDFLM-EALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL  1204

Query  70    FDHL-------VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA---NL  119
                L            +A  +     + I     +    + +HRD+ A N LL       
Sbjct  1205  KSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGR  1264

Query  120   NIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VL  175
               KI DFG + +++      K  C   P  +  PE F    +   K D WS GV+L+ + 
Sbjct  1265  VAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS-KTDTWSFGVLLWEIF  1323

Query  176   VCGALPFDGSTLQNLRARVLSG  197
               G +P+   + Q +   V SG
Sbjct  1324  SLGYMPYPSKSNQEVLEFVTSG  1345


>gi|21431782|sp|Q9H2X6|HIPK2_HUMAN  Homeodomain-interacting protein kinase 2 (hHIPk2)
Length=1198

 Score = 46.6 bits (109),  Expect = 7e-05
 Identities = 39/150 (26%), Positives = 70/150 (46%), Gaps = 9/150 (6%)

Query  43   HIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHC  100
            + +R Y+  + +    LV E      ++D L  +    +  K  R   +Q+ TA+     
Sbjct  259  NFVRAYECFQHKNHTCLVFEMLEQN-LYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS  317

Query  101  RNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGK  156
              ++H DLK EN++L         +K+ DFG ++  +   +  T+  S  Y APE+  G 
Sbjct  318  LGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA-VCSTYLQSRYYRAPEIILGL  376

Query  157  EYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
             +    +D+WSLG V+  L  G   + G++
Sbjct  377  PF-CEAIDMWSLGCVIAELFLGWPLYPGAS  405


>gi|34395641|sp|Q86Z02|HIPK1_HUMAN  Homeodomain-interacting protein kinase 1
Length=1210

 Score = 45.8 bits (107),  Expect = 1e-04
 Identities = 39/150 (26%), Positives = 70/150 (46%), Gaps = 9/150 (6%)

Query  43   HIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHC  100
            + +R Y+  + +    LV E      ++D L  +    +  K  R   +Q+ TA+     
Sbjct  250  NFVRSYECFQHKNHTCLVFEMLEQN-LYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  308

Query  101  RNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGK  156
              ++H DLK EN++L         +K+ DFG ++  +   +  T+  S  Y APE+  G 
Sbjct  309  LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKA-VCSTYLQSRYYRAPEIILGL  367

Query  157  EYDGPKVDIWSLGVVLYVLVCGALPFDGST  186
             +    +D+WSLG V+  L  G   + G++
Sbjct  368  PF-CEAIDMWSLGCVIAELFLGWPLYPGAS  396


>gi|113916|sp|P20594|ANPRB_HUMAN  Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) 
(GC-B) (Guanylate cyclase B) (NPR-B) (Atrial natriuretic 
peptide B-type receptor)
Length=1047

 Score = 45.8 bits (107),  Expect = 1e-04
 Identities = 44/179 (24%), Positives = 79/179 (44%), Gaps = 9/179 (5%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VAIK ++K ++  E  +++  E++ M+ +   H+ R          I +VTEY   G + 
Sbjct  548  VAIKHVNKKRI--ELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQ  605

Query  71   DHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIV-HRDLKAENLLLDANLNIKIADFGF  128
            D L       +   R      +V  + F H   I  H  LK+ N ++D+   +KI D+G 
Sbjct  606  DILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGL  665

Query  129  SNLFTPGQLLKTWC--GSPPYAAPELFEGKEYDG---PKVDIWSLGVVLYVLVCGALPF  182
            ++  +  +   +        + APEL  G         K D++S G++L  +   + PF
Sbjct  666  ASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPF  724


>gi|114039|sp|P02649|APOE_HUMAN  Apolipoprotein E precursor (Apo-E)
Length=317

 Score = 45.4 bits (106),  Expect = 2e-04
 Identities = 35/158 (22%), Positives = 71/158 (44%), Gaps = 8/158 (5%)

Query  1156  WDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPV  1215
             WD ++ + T+   V ++     V+Q        +L   + +    + +  S+L EQL PV
Sbjct  52    WDYLRWVQTLSEQVQEELLSSQVTQ--------ELRALMDETMKELKAYKSELEEQLTPV  103

Query  1216  TQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQ  1275
              +E    L KE +  +  +  D+E+V  ++  Y  + Q    +  E  R ++     +L+
Sbjct  104   AEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLR  163

Query  1276  EGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAP  1313
             +   +   +LQ++L+      R+ A   + A+R  L P
Sbjct  164   KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGP  201


 Score = 38.1 bits (87),  Expect = 0.025
 Identities = 38/140 (27%), Positives = 63/140 (45%), Gaps = 12/140 (8%)

Query  1187  GKQLNLKLLDNWDS---VTSTFSKLREQL--GPVTQEF---WDNLEKETEGLRQEMSKDL  1238
             G++  L L   WD    V +   +++E+L    VTQE     D   KE +  + E+ + L
Sbjct  41    GQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQL  100

Query  1239  ----EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGE  1294
                 EE +A++   L   Q +   +ME    ++   R E+Q    Q   EL+ +L+    
Sbjct  101   TPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLR  160

Query  1295  EMRDRARAHVDALRTHLAPY  1314
             ++R R     D L+  LA Y
Sbjct  161   KLRKRLLRDADDLQKRLAVY  180


>gi|462447|sp|Q04771|ACVR1_HUMAN  Activin receptor type I precursor (ACTR-I) (Serine/threonine-protein 
kinase receptor R1) (SKR1) (Activin receptor-like kinase 
2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I)
Length=509

 Score = 45.4 bits (106),  Expect = 2e-04
 Identities = 54/187 (28%), Positives = 82/187 (43%), Gaps = 30/187 (16%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMK--MLCHPHIIRLYQVMETER----MIYLVTEYA  64
            VA+KI      DE   K  FRE ++    ML H +I+       T R     ++L+T Y 
Sbjct  232  VAVKIFSSR--DE---KSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYH  286

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR--------NIVHRDLKAENLLLD  116
              G ++D+L     +      R    I + +   H           I HRDLK++N+L+ 
Sbjct  287  EMGSLYDYLQLT-TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVK  345

Query  117  ANLNIKIADFGFSNLF--TPGQL---LKTWCGSPPYAAPELFEGKE----YDGPK-VDIW  166
             N    IAD G + +   +  QL        G+  Y APE+ +       +D  K VDIW
Sbjct  346  KNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIW  405

Query  167  SLGVVLY  173
            + G+VL+
Sbjct  406  AFGLVLW  412


>gi|544320|sp|P36888|FLT3_HUMAN  FL cytokine receptor precursor (Tyrosine-protein kinase receptor 
FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen)
Length=993

 Score = 45.4 bits (106),  Expect = 2e-04
 Identities = 36/133 (27%), Positives = 66/133 (49%), Gaps = 9/133 (6%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--  146
            Q+   + F   ++ VHRDL A N+L+     +KI DFG + ++ +    +       P  
Sbjct  794  QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVK  853

Query  147  YAAPE-LFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRI--P  202
            + APE LFEG      K D+WS G++L+ +   G  P+ G  +     +++   F++  P
Sbjct  854  WMAPESLFEG--IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQP  911

Query  203  FFMSTGYFHLLGS  215
            F+ +   + ++ S
Sbjct  912  FYATEEIYIIMQS  924


 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 10/91 (10%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKML-CHPHIIRLYQVMETERMIYLVTEYASGGE  68
            +VA+K++ K + D    + +  E+++M  L  H +I+ L         IYL+ EY   G+
Sbjct  640  QVAVKML-KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGD  698

Query  69   IFDHLVAHGRMAEKEARRKFKQIVTAVYFCH  99
            + ++L        +  R KF +  T ++  H
Sbjct  699  LLNYL--------RSKREKFHRTWTEIFKEH  721


>gi|61213741|sp|Q9H422|HIPK3_HUMAN  Homeodomain-interacting protein kinase 3 (Homolog of protein 
kinase YAK1) (Fas-interacting serine/threonine-protein kinase) 
(FIST) (Androgen receptor-interacting nuclear protein kinase) 
(ANPK)
Length=1215

 Score = 45.1 bits (105),  Expect = 2e-04
 Identities = 42/153 (27%), Positives = 68/153 (44%), Gaps = 15/153 (9%)

Query  43   HIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHC  100
            + +R Y+  +      LV E      ++D L  +    +  K  R   +Q+ TA+     
Sbjct  257  NFVRAYECFQHRNHTCLVFEMLEQN-LYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS  315

Query  101  RNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGK  156
              ++H DLK EN++L         +K+ DFG S       +  T+  S  Y APE+  G 
Sbjct  316  LGLIHADLKPENIMLVDPVRQPYRVKVIDFG-SASHVSKTVCSTYLQSRYYRAPEIILGL  374

Query  157  EYDGPKVDIWSLGVVL------YVLVCGALPFD  183
             +    +D+WSLG V+      + L  GAL +D
Sbjct  375  PF-CEAIDMWSLGCVIAELFLGWPLYPGALEYD  406


>gi|12230224|sp|O43187|IRAK2_HUMAN  Interleukin-1 receptor-associated kinase-like 2 (IRAK-2)
Length=590

 Score = 45.1 bits (105),  Expect = 2e-04
 Identities = 42/170 (24%), Positives = 76/170 (44%), Gaps = 9/170 (5%)

Query  25   NLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKE  83
            ++++ F+ E+QI    CHP+++ +       +    +  Y + G + D L   G      
Sbjct  249  SIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLP  308

Query  84   ARRKFK---QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI----ADFGFSNLFTPGQ  136
              ++      ++ AV + H   I+H ++K+ N+LLD NL  K+    A     N  +   
Sbjct  309  WPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYT  368

Query  137  LLKTWCGSPPYA-APELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS  185
            ++KT       A  PE F        +VDI+S G+VL  ++ G    D +
Sbjct  369  MMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNN  418


>gi|586086|sp|P37173|TGFR2_HUMAN  TGF-beta receptor type II precursor (TGFR-2) (TGF-beta type II 
receptor)
Length=567

 Score = 44.7 bits (104),  Expect = 3e-04
 Identities = 46/201 (22%), Positives = 90/201 (44%), Gaps = 41/201 (20%)

Query  11   VAIKIIDKTQLDEENLKK-IFREVQIMKMLCHPHIIRLYQVMETE----RMIYLVTEYAS  65
            VA+KI    +      +K IF ++ +     H +I++     E +    +  +L+T + +
Sbjct  274  VAVKIFPYEEYASWKTEKDIFSDINLK----HENILQFLTAEERKTELGKQYWLITAFHA  329

Query  66   GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN---------IVHRDLKAENLLLD  116
             G + ++L  H  ++ ++ R+    +   +   H  +         IVHRDLK+ N+L+ 
Sbjct  330  KGNLQEYLTRHV-ISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVK  388

Query  117  ANLNIKIADFGFS----------NLFTPGQLLKTWCGSPPYAAPELFEGK-----EYDGP  161
             +L   + DFG S          +L   GQ+     G+  Y APE+ E +          
Sbjct  389  NDLTCCLCDFGLSLRLDPTLSVDDLANSGQV-----GTARYMAPEVLESRMNLENAESFK  443

Query  162  KVDIWSLGVVLYVLV--CGAL  180
            + D++S+ +VL+ +   C A+
Sbjct  444  QTDVYSMALVLWEMTSRCNAV  464


>gi|3915750|sp|P37023|ACVL1_HUMAN  Serine/threonine-protein kinase receptor R3 precursor (SKR3) 
(Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily 
receptor type I) (TSR-I)
Length=503

 Score = 44.7 bits (104),  Expect = 3e-04
 Identities = 50/187 (26%), Positives = 80/187 (42%), Gaps = 30/187 (16%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMK--MLCHPHIIRLYQVMETER----MIYLVTEYA  64
            VA+KI      DE++    FRE +I    +L H +I+       T R     ++L+T Y 
Sbjct  226  VAVKIFSSR--DEQSW---FRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYH  280

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR--------NIVHRDLKAENLLLD  116
              G ++D L     +    A R        +   H           I HRD K+ N+L+ 
Sbjct  281  EHGSLYDFLQRQ-TLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVK  339

Query  117  ANLNIKIADFGFSNLFTPGQLL-----KTWCGSPPYAAPELFEGKE----YDGPK-VDIW  166
            +NL   IAD G + + + G            G+  Y APE+ + +     ++  K  DIW
Sbjct  340  SNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIW  399

Query  167  SLGVVLY  173
            + G+VL+
Sbjct  400  AFGLVLW  406


>gi|1170674|sp|P29376|LTK_HUMAN  Leukocyte tyrosine kinase receptor precursor (Protein tyrosine 
kinase 1)
Length=864

 Score = 44.3 bits (103),  Expect = 4e-04
 Identities = 51/204 (25%), Positives = 89/204 (43%), Gaps = 20/204 (9%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLY--QVMETERMIYLVTEYASGG  67
            +VAIK + +    ++ L  +  E  I+    H +I+R     +  T R+I L  E  SGG
Sbjct  540  QVAIKTLPELCSPQDELDFLM-EALIISKFRHQNIVRCVGLSLRATPRLILL--ELMSGG  596

Query  68   EIFD-------HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA---  117
            ++         HL     +  ++  +  + I    ++    + +HRD+ A N LL     
Sbjct  597  DMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGP  656

Query  118  NLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-  173
            +   KI DFG + +++      +      P  +  PE F    +   K D WS GV+L+ 
Sbjct  657  SRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTS-KTDSWSFGVLLWE  715

Query  174  VLVCGALPFDGSTLQNLRARVLSG  197
            +   G +P+ G T Q +   V+ G
Sbjct  716  IFSLGYMPYPGRTNQEVLDFVVGG  739


>gi|129892|sp|P16234|PGFRA_HUMAN  Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha) 
(CD140a antigen)
Length=1089

 Score = 43.5 bits (101),  Expect = 6e-04
 Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 13/120 (10%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-------SNLFTPGQLLKTWC  142
            Q+   + F   +N VHRDL A N+LL     +KI DFG        SN  + G       
Sbjct  801  QVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFL---  857

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRI  201
                + APE      Y     D+WS G++L+ +   G  P+ G  + +     +   +R+
Sbjct  858  -PVKWMAPESIFDNLYT-TLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRM  915


 Score = 32.0 bits (71),  Expect = 1.8
 Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 2/65 (3%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGE  68
            KVA+K++  T    E  + +  E++IM  L  H +I+ L         IY++TEY   G+
Sbjct  623  KVAVKMLKPTARSSEK-QALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGD  681

Query  69   IFDHL  73
            + ++L
Sbjct  682  LVNYL  686


>gi|1346369|sp|P49674|KC1E_HUMAN  Casein kinase I isoform epsilon (CKI-epsilon) (CKIe)
Length=416

 Score = 43.5 bits (101),  Expect = 6e-04
 Identities = 32/107 (29%), Positives = 52/107 (48%), Gaps = 14/107 (13%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLF--------TPGQL  137
            Q+++ + + H +N +HRD+K +N L+      NL + I DFG +  +         P + 
Sbjct  111  QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNL-VYIIDFGLAKKYRDARTHQHIPYRE  169

Query  138  LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
             K   G+  YA+     G E    + D+ SLG VL     G+LP+ G
Sbjct  170  NKNLTGTARYASINTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQG  215


>gi|27923980|sp|P48730|KC1D_HUMAN  Casein kinase I isoform delta (CKI-delta) (CKId)
Length=415

 Score = 43.5 bits (101),  Expect = 6e-04
 Identities = 32/107 (29%), Positives = 52/107 (48%), Gaps = 14/107 (13%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLF--------TPGQL  137
            Q+++ + + H +N +HRD+K +N L+      NL + I DFG +  +         P + 
Sbjct  111  QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNL-VYIIDFGLAKKYRDARTHQHIPYRE  169

Query  138  LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
             K   G+  YA+     G E    + D+ SLG VL     G+LP+ G
Sbjct  170  NKNLTGTARYASINTHLGIE-QSRRDDLESLGYVLMYFNLGSLPWQG  215


>gi|47117932|sp|Q9Y6M4|KC1G3_HUMAN  Casein kinase I isoform gamma-3 (CKI-gamma 3)
Length=447

 Score = 43.1 bits (100),  Expect = 8e-04
 Identities = 31/117 (26%), Positives = 56/117 (47%), Gaps = 14/117 (11%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLN-----IKIADFGFSNLF--------TPGQ  136
            Q+++ + + H +N+++RD+K EN L+    N     I I DFG +  +         P +
Sbjct  145  QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYR  204

Query  137  LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRAR  193
              K+  G+  Y +     GKE    + D+ +LG +    + G+LP+ G     L+ R
Sbjct  205  EHKSLTGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER  260


>gi|6226778|sp|O00238|BMR1B_HUMAN  Bone morphogenetic protein receptor type IB precursor (CDw293 
antigen)
Length=502

 Score = 43.1 bits (100),  Expect = 8e-04
 Identities = 46/191 (24%), Positives = 79/191 (41%), Gaps = 36/191 (18%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMK--MLCHPHIIRLYQV----METERMIYLVTEY  63
            KVA+K+   T+         FRE +I +  ++ H +I+           +   +YL+T+Y
Sbjct  227  KVAVKVFFTTEE-----ASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDY  281

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVY-FCHCRN----------IVHRDLKAEN  112
               G ++D+L    +    +A+   K   ++V   CH             I HRDLK++N
Sbjct  282  HENGSLYDYL----KSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKN  337

Query  113  LLLDANLNIKIADFGFSNLF---------TPGQLLKTWCGSPPYAAPELFEGKEYDG-PK  162
            +L+  N    IAD G +  F          P   + T    PP    E      +     
Sbjct  338  ILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIM  397

Query  163  VDIWSLGVVLY  173
             D++S G++L+
Sbjct  398  ADMYSFGLILW  408


>gi|18202957|sp|Q9HCP0|KC1G1_HUMAN  Casein kinase I isoform gamma-1 (CKI-gamma 1)
Length=422

 Score = 43.1 bits (100),  Expect = 8e-04
 Identities = 31/117 (26%), Positives = 56/117 (47%), Gaps = 14/117 (11%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLN-----IKIADFGFSNLF--------TPGQ  136
            Q+++ + + H +N+++RD+K EN L+    N     I I DFG +  +         P +
Sbjct  147  QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR  206

Query  137  LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRAR  193
              K+  G+  Y +     GKE    + D+ +LG +    + G+LP+ G     L+ R
Sbjct  207  EHKSLTGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER  262


>gi|125472|sp|P10721|KIT_HUMAN  Mast/stem cell growth factor receptor precursor (SCFR) (Proto-oncogene 
tyrosine-protein kinase Kit) (c-kit) (CD117 antigen)
Length=976

 Score = 42.7 bits (99),  Expect = 0.001
 Identities = 36/122 (29%), Positives = 54/122 (44%), Gaps = 17/122 (13%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-------SNLFTPG--QLLKT  140
            Q+   + F   +N +HRDL A N+LL      KI DFG        SN    G  +L   
Sbjct  775  QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVK  834

Query  141  WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV-CGALPFDGSTLQNLRARVLSGKF  199
            W       APE      Y   + D+WS G+ L+ L   G+ P+ G  + +   +++   F
Sbjct  835  W------MAPESIFNCVYTF-ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGF  887

Query  200  RI  201
            R+
Sbjct  888  RM  889


>gi|1345920|sp|Q02846|GUC2D_HUMAN  Retinal guanylyl cyclase 1 precursor (Guanylate cyclase 2D, retinal) 
(RETGC-1) (Rod outer segment membrane guanylate cyclase) 
(ROS-GC)
Length=1103

 Score = 42.7 bits (99),  Expect = 0.001
 Identities = 33/145 (22%), Positives = 64/145 (44%), Gaps = 26/145 (17%)

Query  54   ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK-------QIVTAVYFCHCRNIVHR  106
            E  + +V+E+ + G + D L      A++E +  +         ++  + + H R + H 
Sbjct  612  EGNLAVVSEHCTRGSLQDLL------AQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHG  665

Query  107  DLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPP------YAAPELFEGKEYDG  160
             LK+ N ++D    +KI D G   L    ++L      PP      + APEL      + 
Sbjct  666  RLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLP----EPPRAEDQLWTAPELLRDPALER  721

Query  161  PKV---DIWSLGVVLYVLVCGALPF  182
                  D++SL +++  +VC + P+
Sbjct  722  RGTLAGDVFSLAIIMQEVVCRSAPY  746


>gi|24211880|sp|Q8TAS1|UHMK1_HUMAN  Serine/threonine-protein kinase Kist (Kinase interacting with 
stathmin) (U2AF homology motif kinase 1)
Length=419

 Score = 42.4 bits (98),  Expect = 0.001
 Identities = 31/101 (30%), Positives = 44/101 (43%), Gaps = 13/101 (12%)

Query  89   KQIVTAVYFCHCRNIVHRDLKAENLLLDA-NLNIKIADFGFSNLFTPGQLLKTWCGSPPY  147
            + ++ A+ F H    VH DLK  N+L  A N   K+ DFG S  F  G     +  +  Y
Sbjct  140  RDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLS--FKEGNQDVKYIQTDGY  197

Query  148  AAPEL----------FEGKEYDGPKVDIWSLGVVLYVLVCG  178
             APE            +        VD+WSLG++L  +  G
Sbjct  198  RAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSG  238


>gi|129890|sp|P09619|PGFRB_HUMAN  Beta platelet-derived growth factor receptor precursor (PDGF-R-beta) 
(CD140b antigen)
Length=1106

 Score = 42.4 bits (98),  Expect = 0.001
 Identities = 30/101 (29%), Positives = 44/101 (43%), Gaps = 13/101 (12%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-------SNLFTPGQLLKTWC  142
            Q+   + F   +N VHRDL A N+L+     +KI DFG        SN  + G       
Sbjct  809  QVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPL-  867

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
                + APE      Y     D+WS G++L+ +   G  P+
Sbjct  868  ---KWMAPESIFNSLYT-TLSDVWSFGILLWEIFTLGGTPY  904


 Score = 34.7 bits (78),  Expect = 0.28
 Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 2/69 (2%)

Query  6    QFAAKVAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYA  64
            Q   KVA+K++  T    E  + +  E++IM  L  H +++ L         IY++TEY 
Sbjct  626  QATMKVAVKMLKSTARSSEK-QALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYC  684

Query  65   SGGEIFDHL  73
              G++ D+L
Sbjct  685  RYGDLVDYL  693


>gi|1705919|sp|P49760|CLK2_HUMAN  Dual specificity protein kinase CLK2 (CDC-like kinase 2)
Length=499

 Score = 42.0 bits (97),  Expect = 0.002
 Identities = 70/315 (22%), Positives = 120/315 (38%), Gaps = 67/315 (21%)

Query  9    AKVAIKII-------DKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVT  61
            A+VA+KII       +  +L+   L+KI  +    K LC    ++++   +    + +  
Sbjct  188  ARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLC----VQMFDWFDYHGHMCISF  243

Query  62   EYASGGEIFDHLVAHGRMAEK--EARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-----  114
            E   G   FD L  +  +     + R    Q+  AV F H   + H DLK EN+L     
Sbjct  244  ELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSD  302

Query  115  --LDANLN------------IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDG  160
              L  NL             +++ DFG +      +   T   +  Y APE+     +  
Sbjct  303  YELTYNLEKKRDERSVKSTAVRVVDFGSATF--DHEHHSTIVSTRHYRAPEVILELGWSQ  360

Query  161  PKVDIWSLGVVLYVLVCGAL-------------------PFDGSTLQNLRARVLSGKFRI  201
            P  D+WS+G +++    G                     P     ++  R +    + R+
Sbjct  361  P-CDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRL  419

Query  202  PFFMSTGYFHLLGSHCNVVLNAKDKRLKAGCLSIAECEH----LIRHMLVLDPNKRLSME  257
             +  +T     +  +C        K L+    S AE  H    LI  ML  +P KRL++ 
Sbjct  420  DWDENTSAGRYVRENC--------KPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLG  471

Query  258  QICKHKWMKLGDADP  272
            +  +H +     A+P
Sbjct  472  EALQHPFFARLRAEP  486


>gi|113912|sp|P16066|ANPRA_HUMAN  Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) 
(GC-A) (Guanylate cyclase) (NPR-A) (Atrial natriuretic peptide 
A-type receptor)
Length=1061

 Score = 41.2 bits (95),  Expect = 0.003
 Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 16/172 (9%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  70
            VA+K +++ ++  E  +K+  E++ M+ + + H+ R          I ++TEY   G + 
Sbjct  564  VAVKRVNRKRI--ELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQ  621

Query  71   DHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIV-HRDLKAENLLLDANLNIKIADFGF  128
            D L       +   R      IV  + F H   I  H +LK+ N ++D    +KI D+G 
Sbjct  622  DILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGL  681

Query  129  SNL--FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV------DIWSLGVVL  172
             +     P Q   T      + APEL        P V      D++S G++L
Sbjct  682  ESFRDLDPEQ-GHTVYAKKLWTAPELL---RMASPPVRGSQAGDVYSFGIIL  729


>gi|547775|sp|P36896|ACV1B_HUMAN  Activin receptor type 1B precursor (ACTR-IB) (Serine/threonine-protein 
kinase receptor R2) (SKR2) (Activin receptor-like 
kinase 4) (ALK-4)
Length=505

 Score = 41.2 bits (95),  Expect = 0.003
 Identities = 49/191 (25%), Positives = 81/191 (42%), Gaps = 38/191 (19%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMK--MLCHPHIIRLYQVMETER----MIYLVTEYA  64
            VA+KI    +      +  FRE +I +  ML H +I+        +      ++LV++Y 
Sbjct  231  VAVKIFSSREE-----RSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYH  285

Query  65   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR--------NIVHRDLKAENLLLD  116
              G +FD+L  +    E   +       + +   H           I HRDLK++N+L+ 
Sbjct  286  EHGSLFDYLNRYTVTIEGMIKLALSA-ASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVK  344

Query  117  ANLNIKIADFGFSNL---------FTPGQLLKTWCGSPPYAAPELFEG----KEYDGPK-  162
             N    IAD G +             P Q +    G+  Y APE+ +     K +D  K 
Sbjct  345  KNGMCAIADLGLAVRHDAVTDTIDIAPNQRV----GTKRYMAPEVLDETINMKHFDSFKC  400

Query  163  VDIWSLGVVLY  173
             DI++LG+V +
Sbjct  401  ADIYALGLVYW  411


>gi|55584013|sp|Q9Y616|IRAK3_HUMAN  Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated 
kinase M) (IRAK-M)
Length=596

 Score = 40.8 bits (94),  Expect = 0.004
 Identities = 38/182 (20%), Positives = 78/182 (42%), Gaps = 16/182 (8%)

Query  12   AIKII--DKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI  69
            A+K+   +K    +++ K+   E++++ +  HP+I+ L           L+  Y   G +
Sbjct  190  AVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTL  249

Query  70   FDHLVAHGRMAEKEARRKFKQIV---TAVYFCH----CRNIVHRDLKAENLLLDANLNIK  122
            FD L   G  A      +   ++    A+++ H    C +++   + + N+LLD     K
Sbjct  250  FDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPC-SVICGSISSANILLDDQFQPK  308

Query  123  IADFGF----SNLFTPGQLLKTWCGSPPYA--APELFEGKEYDGPKVDIWSLGVVLYVLV  176
            + DF      S+L      +     S  +    PE +  +     K D++S G+V+  ++
Sbjct  309  LTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVL  368

Query  177  CG  178
             G
Sbjct  369  TG  370


>gi|3024060|sp|P78368|KC1G2_HUMAN  Casein kinase I isoform gamma-2 (CKI-gamma 2)
Length=415

 Score = 40.4 bits (93),  Expect = 0.005
 Identities = 30/117 (25%), Positives = 55/117 (47%), Gaps = 14/117 (11%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLL-----DANLNIKIADFGFSNLF--------TPGQ  136
            Q++T + + H +++++RD+K EN L+          I I DFG +  +         P +
Sbjct  148  QLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYR  207

Query  137  LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRAR  193
              K+  G+  Y +     GKE    + D+ +LG +    + G+LP+ G     L+ R
Sbjct  208  EHKSLTGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKER  263


>gi|67476728|sp|P42566|EP15_HUMAN  Epidermal growth factor receptor substrate 15 (Protein Eps15) 
(AF-1p protein)
Length=896

 Score = 40.4 bits (93),  Expect = 0.005
 Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 27/117 (23%)

Query  1217  QEFWDNLEKETEGLR---------QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKV  1267
             Q+  D +++E   L+         QE+  +L+E KA+++  L + +KK  EE +L    +
Sbjct  371   QDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL----I  426

Query  1268  EPLRAEL--QEG-----------ARQKLHELQEKLSPLGEEMRDRARAHVDALRTHL  1311
               L+AEL  QE            AR++L  LQ++ + L EE  +  +A ++ L+ HL
Sbjct  427   SSLKAELTSQESQISTYEEELAKAREELSRLQQETAEL-EESVESGKAQLEPLQQHL  482


>gi|547777|sp|P36897|TGFR1_HUMAN  TGF-beta receptor type I precursor (TGFR-1) (TGF-beta type I 
receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) 
(Activin receptor-like kinase 5) (ALK-5)
Length=503

 Score = 40.0 bits (92),  Expect = 0.007
 Identities = 48/190 (25%), Positives = 80/190 (42%), Gaps = 34/190 (17%)

Query  10   KVAIKIIDKTQLDEENLKKIFREVQIMK--MLCHPHIIRLYQVMETER----MIYLVTEY  63
            +VA+KI    +      +  FRE +I +  ML H +I+        +      ++LV++Y
Sbjct  228  EVAVKIFSSREE-----RSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDY  282

Query  64   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN----------IVHRDLKAENL  113
               G +FD+L  +    E   +       TA    H             I HRDLK++N+
Sbjct  283  HEHGSLFDYLNRYTVTVEGMIKLALS---TASGLAHLHMEIVGTQGKPAIAHRDLKSKNI  339

Query  114  LLDANLNIKIADFGF-----SNLFTPGQLLKTWCGSPPYAAPELFEG----KEYDG-PKV  163
            L+  N    IAD G      S   T         G+  Y APE+ +     K ++   + 
Sbjct  340  LVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRA  399

Query  164  DIWSLGVVLY  173
            DI+++G+V +
Sbjct  400  DIYAMGLVFW  409


>gi|20141240|sp|P49761|CLK3_HUMAN  Dual specificity protein kinase CLK3 (CDC-like kinase 3)
Length=490

 Score = 39.7 bits (91),  Expect = 0.009
 Identities = 72/308 (23%), Positives = 117/308 (37%), Gaps = 73/308 (23%)

Query  9    AKVAIKII-------DKTQLDEENLKKIFREVQIMKMLC---------HPHIIRLYQVME  52
            ++VA+KII       +  +L+   LKKI  + +  K LC         H H+   ++++ 
Sbjct  181  SQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLG  240

Query  53   TERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN  112
                     E+        + + H        R    Q+  A+ F H   + H DLK EN
Sbjct  241  KNTF-----EFLKENNFQPYPLPH-------VRHMAYQLCHALRFLHENQLTHTDLKPEN  288

Query  113  LLL-------------------DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELF  153
            +L                      N +I++ADFG +      +   T   +  Y  PE+ 
Sbjct  289  ILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF--DHEHHTTIVATRHYRPPEVI  346

Query  154  EGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKF--RIPFFM-----S  206
                +  P  D+WS+G +L+    G   F   T +N    V+  K    IP  M      
Sbjct  347  LELGWAQP-CDVWSIGCILFEYYRGFTLF--QTHENREHLVMMEKILGPIPSHMIHRTRK  403

Query  207  TGYFHLLGSHCNVVLNAKDKR-LKAGCLSIA------ECEH-----LIRHMLVLDPNKRL  254
              YF+  G   +   N+ D R +K  C  +         EH     L+R ML  DP +R+
Sbjct  404  QKYFYKGGLVWDE--NSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRI  461

Query  255  SMEQICKH  262
            ++ +   H
Sbjct  462  TLAEALLH  469


>gi|34222508|sp|Q15075|EEA1_HUMAN  Early endosome antigen 1 (Endosome-associated protein p162) (Zinc 
finger FYVE domain-containing protein 2)
Length=1411

 Score = 39.7 bits (91),  Expect = 0.009
 Identities = 35/137 (25%), Positives = 70/137 (51%), Gaps = 20/137 (14%)

Query  1189  QLNLKLLDNW--DSVTSTFSKLREQLGPVTQEFWDN--LEKETEGLRQEMSKDLEEVKAK  1244
             QL L  L+    + VT++ ++L+ QL    Q+  +   L++ T    +E   DLE+V  +
Sbjct  459   QLKLSRLEEQLKEKVTNS-TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ  517

Query  1245  VQPY------LDDFQKKWQEEMELYRQKVEPLRAELQEGA---------RQKLHELQEKL  1289
             +         L+   +K +E + L  ++ E L A++Q G          ++K H LQE++
Sbjct  518   IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV  577

Query  1290  SPLGEEMRDRARAHVDA  1306
             + L E++++++ +H  A
Sbjct  578   TQLTEKLKNQSESHKQA  594


 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 33/123 (26%), Positives = 61/123 (49%), Gaps = 22/123 (17%)

Query  1189  QLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSK---DLEEVKAKV  1245
             Q+  KL D  +  +   S L+E      +E + +LE++TE L  ++ K   D  EVKA  
Sbjct  692   QVTAKLQDKQEHCSQLESHLKEY-----KEKYLSLEQKTEELEGQIKKLEADSLEVKASK  746

Query  1246  QPYLDDFQKKWQ-------------EEMELYRQKVEPLRAELQEGARQKLHELQEKLSPL  1292
             +  L D Q++ Q             +++E+ ++ V   R +LQ+ + + L  +++KL+  
Sbjct  747   EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS-EALESIKQKLTKQ  805

Query  1293  GEE  1295
              EE
Sbjct  806   EEE  808


>gi|547770|sp|P07333|CSF1R_HUMAN  Macrophage colony-stimulating factor 1 receptor precursor (CSF-1-R) 
(Fms proto-oncogene) (c-fms) (CD115 antigen)
Length=972

 Score = 39.3 bits (90),  Expect = 0.011
 Identities = 29/99 (29%), Positives = 47/99 (47%), Gaps = 5/99 (5%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN--LFTPGQLLKTWCGSP-P  146
            Q+   + F   +N +HRD+ A N+LL      KI DFG +   +     ++K     P  
Sbjct  761  QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK  820

Query  147  YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG  184
            + APE      Y   + D+WS G++L+ +   G  P+ G
Sbjct  821  WMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPG  858


>gi|12643724|sp|Q13873|BMPR2_HUMAN  Bone morphogenetic protein receptor type II precursor (BMP type 
II receptor) (BMPR-II)
Length=1038

 Score = 38.9 bits (89),  Expect = 0.015
 Identities = 46/178 (25%), Positives = 75/178 (42%), Gaps = 34/178 (19%)

Query  25   NLKKIFREVQIMKMLCHPHIIRLY----QVMETERMIYL-VTEYASGGEIFDHLVAHGRM  79
            N K I+R    + ++ H +I R      +V    RM YL V EY   G +  +L  H   
Sbjct  242  NEKNIYR----VPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSD  297

Query  80   AEKEARRKFKQIVTAVYFCHCR---------NIVHRDLKAENLLLDANLNIKIADFGFSN  130
                 R     +   + + H            I HRDL + N+L+  +    I+DFG S 
Sbjct  298  WVSSCRLAHS-VTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSM  356

Query  131  LFTPGQLLK---------TWCGSPPYAAPELFEGK------EYDGPKVDIWSLGVVLY  173
              T  +L++         +  G+  Y APE+ EG       E    +VD+++LG++ +
Sbjct  357  RLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYW  414


>gi|123682|sp|P25092|GUC2C_HUMAN  Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal 
guanylate cyclase) (STA receptor) (hSTAR)
Length=1073

 Score = 38.9 bits (89),  Expect = 0.015
 Identities = 33/152 (21%), Positives = 71/152 (46%), Gaps = 16/152 (10%)

Query  32   EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG---EIFDHLVAH--GRMAEKEARR  86
            E+  +  + + ++ + Y  ++ + MI+ V EY   G   E+ +  +++  G   + E + 
Sbjct  532  ELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKI  591

Query  87   K-FKQIVTAVYFCHC-RNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS  144
                 I   + + H  +  VH  LK+ N ++D+ + +KI DFG +++  P + L      
Sbjct  592  SVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL------  645

Query  145  PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV  176
              + APE          K D++S G++   ++
Sbjct  646  --WTAPEHLRQANI-SQKGDVYSYGIIAQEII  674


>gi|23822112|sp|Q9P2E9|RRBP1_HUMAN  Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa 
ribosome receptor homolog) (ES/130-related protein)
Length=1410

 Score = 38.5 bits (88),  Expect = 0.019
 Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 5/90 (5%)

Query  1225  KETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEG--ARQKL  1282
             +ET+   Q        + A+ +  L D QK  +EE +++R KV     ELQ+     + L
Sbjct  1118  EETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHL  1177

Query  1283  HELQEKLSPLGE-EMRDRARAHVDALRTHL  1311
              E+ EKL   GE E  D+ R H   L   L
Sbjct  1178  EEIVEKLK--GELESSDQVREHTSHLEAEL  1205


 Score = 34.3 bits (77),  Expect = 0.37
 Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 2/98 (2%)

Query  1206  SKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQ  1265
             S LR+ L   T +       E   LRQE+SK  +E+  K +    D Q++  + +E    
Sbjct  803   SILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQR--KALEAKAA  860

Query  1266  KVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAH  1303
               E    +LQ   R+    LQ++L  +  E+     +H
Sbjct  861   AFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSH  898


>gi|21264536|sp|P45379|TNNT2_HUMAN  Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) 
(cTnT)
Length=298

 Score = 38.5 bits (88),  Expect = 0.019
 Identities = 22/69 (31%), Positives = 40/69 (57%), Gaps = 1/69 (1%)

Query  1231  RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS  1290
             R+ M KDL E++A ++ + ++ +KK +EE+   + ++E  RAE  E  R +    +E+ +
Sbjct  102   RKRMEKDLNELQALIEAHFEN-RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN  160

Query  1291  PLGEEMRDR  1299
              L EE   R
Sbjct  161   RLAEERARR  169


>gi|83305809|sp|Q96KB5|TOPK_HUMAN  T-lymphokine-activated killer cell-originated protein kinase 
(T-LAK cell-originated protein kinase) (PDZ-binding kinase) 
(Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein 
kinase) (Nori-3)
Length=322

 Score = 38.5 bits (88),  Expect = 0.019
 Identities = 38/168 (22%), Positives = 73/168 (43%), Gaps = 14/168 (8%)

Query  27   KKIFREVQIMKMLCHPHIIRLYQVME-TERMIYLVTEYASGGEIFDHLVAHGRMAEKEAR  85
            K++  E +I+K L HP+I+      E  +  + L  EY  G +  + L+     A ++  
Sbjct  80   KRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEY-GGEKSLNDLIEERYKASQDPF  138

Query  86   RKFKQIVTAV-------YFCHCRNIVHRDLKAENLLLDANL-NIKIADFGFS----NLFT  133
                 +  A+       Y    + ++H D+K+ N+++  +   IKI D G S       T
Sbjct  139  PAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMT  198

Query  134  PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP  181
                   + G+ P+   E  E       K DI++ G+ L+ ++  ++P
Sbjct  199  VTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP  246


>gi|9973397|sp|Q13418|ILK1_HUMAN  Integrin-linked protein kinase 1 (ILK-1) (59 kDa serine/threonine-protein 
kinase) (p59ILK)
Length=452

 Score = 38.1 bits (87),  Expect = 0.025
 Identities = 36/182 (19%), Positives = 81/182 (44%), Gaps = 16/182 (8%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY--LVTEYASGGE  68
            + +K++          +    E   +++  HP+++ +    ++    +  L+T +   G 
Sbjct  217  IVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGS  276

Query  69   IFD--HLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKI-  123
            +++  H   +  + + +A +    +   + F H     I    L + ++++D ++  +I 
Sbjct  277  LYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS  336

Query  124  -ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK--VDIWSLGVVLYVLVCGAL  180
             AD  FS    PG++      +P + APE  + K  D  +   D+WS  V+L+ LV   +
Sbjct  337  MADVKFS-FQCPGRMY-----APAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREV  390

Query  181  PF  182
            PF
Sbjct  391  PF  392


>gi|31077177|sp|P48729|KC1A_HUMAN  Casein kinase I isoform alpha (CKI-alpha) (CK1)
Length=337

 Score = 38.1 bits (87),  Expect = 0.025
 Identities = 28/106 (26%), Positives = 50/106 (47%), Gaps = 12/106 (11%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFGFSNLF--------TPGQLL  138
            Q+++ + + H +N +HRD+K +N L+    +   + + DFG +  +         P +  
Sbjct  119  QMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRED  178

Query  139  KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
            K   G+  YA+     G E    + D+ SLG VL      +LP+ G
Sbjct  179  KNLTGTARYASINAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQG  223


>gi|9973390|sp|P57043|ILK2_HUMAN  Integrin-linked protein kinase 2 (ILK-2)
Length=452

 Score = 37.7 bits (86),  Expect = 0.033
 Identities = 36/182 (19%), Positives = 80/182 (43%), Gaps = 16/182 (8%)

Query  11   VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY--LVTEYASGGE  68
            + +K++          +    E   +++  HP+++ +    +     +  L+T +   G 
Sbjct  217  IVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHPTLITHWMPYGS  276

Query  69   IFD--HLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKI-  123
            +++  H   +  + + +A +    +   + F H     I    L + ++++D ++  +I 
Sbjct  277  LYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS  336

Query  124  -ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK--VDIWSLGVVLYVLVCGAL  180
             AD  FS    PG++      +P + APE  + K  D  +   D+WS  V+L+ LV   +
Sbjct  337  MADVKFS-FQCPGRMY-----APAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREV  390

Query  181  PF  182
            PF
Sbjct  391  PF  392


>gi|20178343|sp|Q14141|SEPT6_HUMAN  Septin-6
Length=434

 Score = 37.4 bits (85),  Expect = 0.043
 Identities = 20/61 (32%), Positives = 38/61 (62%), Gaps = 1/61 (1%)

Query  1239  EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
             E  +AK   +L + QKK +E  +++ Q+V+   AEL+E A ++LHE  ++L  L ++ + 
Sbjct  322   ETYEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKE-AEKELHEKFDRLKKLHQDEKK  380

Query  1299  R  1299
             +
Sbjct  381   K  381


>gi|82581558|sp|Q8TDY2|RBCC1_HUMAN  RB1-inducible coiled-coil protein 1
Length=1594

 Score = 36.6 bits (83),  Expect = 0.074
 Identities = 25/108 (23%), Positives = 51/108 (47%), Gaps = 1/108 (0%)

Query  1190  LNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYL  1249
             L ++ +  ++ V +      E+L    Q+  + +++    + QE  K L+E+K KV   L
Sbjct  995   LQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSD-L  1053

Query  1250  DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR  1297
              D + K + E+ L   + + ++  L+E   Q+   L+  L    E +R
Sbjct  1054  SDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLR  1101


 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 4/64 (6%)

Query  1226  ETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHEL  1285
             E E +    + +++E+K   +  L+D +K   E  E    K++ LRAELQ   +  L EL
Sbjct  936   EMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDE----KLQLLRAELQSLEQSHLKEL  991

Query  1286  QEKL  1289
             ++ L
Sbjct  992   EDTL  995


 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 13/26 (50%), Positives = 15/26 (57%), Gaps = 0/26 (0%)

Query  490  PRGPSPLVTMTPAVPAVTPVDEESSD  515
            PR P PL    P  PAV P++E S D
Sbjct  668  PRTPPPLTVQDPLCPAVCPLEELSPD  693


>gi|417216|sp|P33176|KINH_HUMAN  Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC)
Length=963

 Score = 36.6 bits (83),  Expect = 0.074
 Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 11/109 (10%)

Query  1204  TFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELY  1263
             T +++++ +    Q   +  +K+   LR E+     E KAK+   L D  +K   E E  
Sbjct  693   TANEVKQAVEQQIQSHRETHQKQISSLRDEV-----EAKAKLITDLQDQNQKMMLEQERL  747

Query  1264  RQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLA  1312
             R + E L+A  QE +R KLHEL      + ++ R++AR  +  L   +A
Sbjct  748   RVEHEKLKATDQEKSR-KLHEL-----TVMQDRREQARQDLKGLEETVA  790


>gi|74753268|sp|Q9UDT6|CYLN2_HUMAN  Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) 
(CLIP-115) (Williams-Beuren syndrome chromosome region 4 protein)
Length=1046

 Score = 36.2 bits (82),  Expect = 0.096
 Identities = 42/158 (26%), Positives = 61/158 (38%), Gaps = 20/158 (12%)

Query  1167  VDVLKDSGRDYVSQFEGSALGKQL----NLKLLDNW----DSVTSTFSKLREQLGPVTQE  1218
             VD L+ +   Y  +  G     Q     N+ L+DNW    DS+ S   K  E L      
Sbjct  578   VDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNS  637

Query  1219  FWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGA  1278
                  +KE   L+  M    E +K + Q  L + Q K   E  ++ ++ E LR       
Sbjct  638   GPGAQQKEIGELKAVM----EGIKMEHQLELGNLQAKHDLETAMHVKEKEALR-------  686

Query  1279  RQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSD  1316
              +KL E QE+L+ L    R +        R  L    D
Sbjct  687   -EKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQD  723


>gi|8928535|sp|P51617|IRAK1_HUMAN  Interleukin-1 receptor-associated kinase 1 (IRAK-1)
Length=712

 Score = 36.2 bits (82),  Expect = 0.096
 Identities = 29/123 (23%), Positives = 54/123 (43%), Gaps = 7/123 (5%)

Query  14   KIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDH  72
            ++ +   L+   +K+ F  EV+ +    HP+I+             LV  +   G + D 
Sbjct  240  RLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDR  299

Query  73   LVAHGRMAEKEARRKFKQIVT----AVYFCH--CRNIVHRDLKAENLLLDANLNIKIADF  126
            L    +     +  +   I+     A+ F H    +++H D+K+ N+LLD  L  K+ DF
Sbjct  300  LHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDF  359

Query  127  GFS  129
            G +
Sbjct  360  GLA  362


>gi|1710811|sp|P34925|RYK_HUMAN  Tyrosine-protein kinase RYK precursor
Length=604

 Score = 36.2 bits (82),  Expect = 0.096
 Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 5/97 (5%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ---LLKTWCGSPP  146
            QI   + +   R ++H+DL A N ++D  L +KI D   S    P     L         
Sbjct  445  QIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVR  504

Query  147  YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF  182
            + A E     E+     D+W+ GV L+ ++  G  P+
Sbjct  505  WMALESLVNNEFSSAS-DVWAFGVTLWELMTLGQTPY  540


>gi|14194461|sp|Q99996|AKAP9_HUMAN  A-kinase anchor protein 9 (Protein kinase A-anchoring protein 
9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase 
anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 
120-like protein) (Hyperion protein) (Yotiao protein) (Centrosome- 
and Golgi-localized PKN-associated protein) (CG-NAP)
Length=3911

 Score = 36.2 bits (82),  Expect = 0.096
 Identities = 33/135 (24%), Positives = 69/135 (51%), Gaps = 18/135 (13%)

Query  1192  LKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDD  1251
             L+L D   +      +L+EQ+    QE   N++ E    +Q+  +  EE+K ++   +++
Sbjct  358   LELKDKLTTADKLLGELQEQIVQKNQEI-KNMKLELTNSKQKERQSSEEIK-QLMGTVEE  415

Query  1252  FQKKWQEEMELY-----------RQKVEPLRAELQEGARQKLHELQEKL----SPLGEEM  1296
              QK+  ++ +             ++K+E LRAEL E   Q++ +++++L        EEM
Sbjct  416   LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM  475

Query  1297  RDRARAHVD-ALRTH  1310
             + R +  ++ ALR++
Sbjct  476   KTRHKGEMENALRSY  490


 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 22/82 (26%), Positives = 43/82 (52%), Gaps = 9/82 (10%)

Query  1227  TEGLRQEMSKDLEEVKAKVQPYLDDFQK------KWQEEMELYRQ---KVEPLRAELQEG  1277
             +E L +E+ K LEE  +++   L++ +K      + +++ME  RQ   K      E    
Sbjct  3345  SEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTE  3404

Query  1278  ARQKLHELQEKLSPLGEEMRDR  1299
              ++K+HELQ K+  L  ++ ++
Sbjct  3405  GQKKMHELQSKVEDLQRQLEEK  3426


>gi|17375490|sp|Q14203|DYNA_HUMAN  Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) 
(p150-glued) (p135)
Length=1278

 Score = 35.8 bits (81),  Expect = 0.13
 Identities = 40/151 (26%), Positives = 72/151 (47%), Gaps = 20/151 (13%)

Query  1182  EGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSK---DL  1238
             E +A  K   +++ D   S      KL++ +    QE  + + ++ E L++E+S+    +
Sbjct  365   EQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQEL-EVVRQQRERLQEELSQAESTI  423

Query  1239  EEVKAKVQP---------YLDDFQKKWQEEMELYRQKVEPLRA------ELQEGARQKLH  1283
             +E+K +V            L D     +E++   R+ V  L A      ELQE AR+   
Sbjct  424   DELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETEL  483

Query  1284  ELQEKLSPLGEEMRDRARAHVDALRTHLAPY  1314
             EL+E+L   G  +R+ A+  V+A +  +A Y
Sbjct  484   ELREQLDMAGARVRE-AQKRVEAAQETVADY  513


>gi|33518637|sp|P45378|TNNT3_HUMAN  Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle 
troponin T) (fTnT) (Beta TnTF)
Length=269

 Score = 35.8 bits (81),  Expect = 0.13
 Identities = 20/69 (28%), Positives = 40/69 (57%), Gaps = 1/69 (1%)

Query  1231  RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS  1290
             ++  +KDL E++A +  + +  +KK +EE+   ++++E  RAE  E  R +  + +E+ +
Sbjct  72    KKRQNKDLMELQALIDSHFEA-RKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQN  130

Query  1291  PLGEEMRDR  1299
              L EE   R
Sbjct  131   RLAEEKARR  139


>gi|1709851|sp|P23246|SFPQ_HUMAN  Splicing factor, proline- and glutamine-rich (Polypyrimidine 
tract-binding protein-associated splicing factor) (PTB-associated 
splicing factor) (PSF) (DNA-binding p52/p100 complex, 
100 kDa subunit) (100-kDa DNA-pairing protein) (hPOMp100)
Length=707

 Score = 35.4 bits (80),  Expect = 0.16
 Identities = 32/111 (28%), Positives = 55/111 (49%), Gaps = 14/111 (12%)

Query  1198  WDSVTSTFSKLREQLGPVTQEFWDNLEKETEG---------LRQEMSKDLEEVKAKVQPY  1248
             W S+     + REQ+    ++  D LE E E          LRQ++ +  EE++   + +
Sbjct  494   WKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELH  553

Query  1249  LDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDR  1299
               + QK+  +EM+L RQ+ E  R E +   RQ+  E++E++    EE   R
Sbjct  554   NQEMQKR--KEMQL-RQEEERRRREEEMMIRQR--EMEEQMRRQREESYSR  599


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 17/42 (40%), Positives = 18/42 (42%), Gaps = 4/42 (9%)

Query  886  PTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPP  927
            P Q  + PP  Q P   P  HQ PPH      QQ    P PP
Sbjct  65   PHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQ----PPPP  102


>gi|1174800|sp|P13805|TNNT1_HUMAN  Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle 
troponin T) (sTnT)
Length=278

 Score = 35.4 bits (80),  Expect = 0.16
 Identities = 19/65 (29%), Positives = 38/65 (58%), Gaps = 1/65 (1%)

Query  1231  RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS  1290
             R+ M KDL E++  +  + +  +KK +EE+   ++++E  R+E  E  R +  + +E+ +
Sbjct  68    RKRMEKDLLELQTLIDVHFEQ-RKKEEEELVALKERIERRRSERAEQQRFRTEKERERQA  126

Query  1291  PLGEE  1295
              L EE
Sbjct  127   KLAEE  131


>gi|1346640|sp|P35580|MYH10_HUMAN  Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin 
heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin 
heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B)
Length=1976

 Score = 35.4 bits (80),  Expect = 0.16
 Identities = 28/141 (19%), Positives = 65/141 (46%), Gaps = 13/141 (9%)

Query  1178  VSQFEGSALGKQLNLKLL-DNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSK  1236
             ++Q E     +Q N++LL D +   T     L  +L         +  ++++  RQ++ +
Sbjct  1738  IAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER-----SAAQKSDNARQQLER  1792

Query  1237  DLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK------LHELQEKLS  1290
               +E+KAK+Q      + K++  +     K+  L  +L++ A+++      +   ++KL 
Sbjct  1793  QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK  1852

Query  1291  PLGEEMRDRARAHVDALRTHL  1311
              +  ++ D  R H D  +  +
Sbjct  1853  EIFMQVEDE-RRHADQYKEQM  1872


>gi|33301318|sp|Q92614|MY18A_HUMAN  Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule 
associated with JAK3 N-terminus) (MAJN)
Length=2054

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 25/95 (26%), Positives = 51/95 (53%), Gaps = 12/95 (12%)

Query  1221  DNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQ----------KVEPL  1270
             D++ K    L +++S+ L+  K ++Q  L++ Q+   E M+ ++           ++  L
Sbjct  1721  DDIAKAKTALEEQLSR-LQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDL  1779

Query  1271  RAELQEGARQKLHELQEKLSPLGEEMRDRARAHVD  1305
             +A+L+E  ++K  ELQEKL  L  ++    ++ VD
Sbjct  1780  QAQLEEANKEK-QELQEKLQALQSQVEFLEQSMVD  1813


 Score = 33.1 bits (74),  Expect = 0.82
 Identities = 35/166 (21%), Positives = 71/166 (42%), Gaps = 10/166 (6%)

Query  1140  SQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWD  1199
             SQA    Q+++  +    R KD+       LK    +      G     Q  + L     
Sbjct  1468  SQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFT---QKVVSLEAELQ  1524

Query  1200  SVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKD------LEEVKAKVQPYLDDFQ  1253
              ++S  SK    L  V ++  D LE + +   +E+ +       LE+ K +++  ++  +
Sbjct  1525  DISSQESKDEASLAKVKKQLRD-LEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMR  1583

Query  1254  KKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDR  1299
             +   +EME   ++VE  R   Q+  +Q   +L+E+     + +R++
Sbjct  1584  QTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREK  1629


>gi|20455324|sp|Q9H2D6|TARA_HUMAN  TRIO and F-actin binding protein (Protein Tara) (Trio-associated 
repeat on actin)
Length=593

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 23/91 (25%), Positives = 46/91 (50%), Gaps = 6/91 (6%)

Query  1222  NLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK  1281
             +L++  +GLR++   D+E +K ++Q   + + +K  E   L RQ      AE +E   ++
Sbjct  407   SLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQ------AEEREHTLRR  460

Query  1282  LHELQEKLSPLGEEMRDRARAHVDALRTHLA  1312
               +  ++L    +E+  R    +D LR  +A
Sbjct  461   CQQEGQELLRHNQELHGRLSEEIDQLRGFIA  491


>gi|1346343|sp|P04264|K2C1_HUMAN  Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) 
(K1) (67 kDa cytokeratin) (Hair alpha protein)
Length=644

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 30/131 (22%), Positives = 60/131 (45%), Gaps = 6/131 (4%)

Query  1170  LKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLR-EQLGPVTQEFWDNLEKETE  1228
             +K     + S  +     +Q N  L   W+ +    +  R   L P  + F +NL +  +
Sbjct  184   IKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVD  243

Query  1229  GLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQ---EGARQKLHEL  1285
              L+ + S+   E+K  +Q  ++D++ K+++E+   R   E     ++   +GA     +L
Sbjct  244   QLKSDQSRLDSELK-NMQDMVEDYRNKYEDEIN-KRTNAENEFVTIKKDVDGAYMTKVDL  301

Query  1286  QEKLSPLGEEM  1296
             Q KL  L +E+
Sbjct  302   QAKLDNLQQEI  312


>gi|586120|sp|Q07283|TRHY_HUMAN  Trichohyalin
Length=1898

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 17/110 (15%)

Query  1209  REQLGPVTQEFWDNLEKETEGLRQEMSKD------LEEVKAK------VQPYLDDFQKKW  1256
             R +     QE  D L+++ E  RQE  +D      LEE + +       +P L +  +K 
Sbjct  860   RRERAQQLQEEEDGLQEDQERRRQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE  919

Query  1257  Q-----EEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR  1301
             Q     EE EL R++ E  R + QE   ++  +LQ++   L  E R++ R
Sbjct  920   QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR  969


 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 25/101 (24%), Positives = 50/101 (49%), Gaps = 2/101 (1%)

Query  1208  LREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKV  1267
             LRE+     ++ W+   ++ + L+QE  + L E + K +  L + +++++EE EL +++ 
Sbjct  1021  LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR--LQERERQYREEEELQQEEE  1078

Query  1268  EPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALR  1308
             + L  E +   RQ+L     K   L +E     R   +  R
Sbjct  1079  QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR  1119


 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 25/83 (30%), Positives = 42/83 (50%), Gaps = 4/83 (4%)

Query  1224  EKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLH  1283
             ++E + LR+E  K   +   +     D+ Q   QEE +L R++ E  R + +E   ++  
Sbjct  1015  QEEEQLLREEREKRRRQEWERQYRKKDELQ---QEEEQLLREEREKRRLQERERQYREEE  1071

Query  1284  EL-QEKLSPLGEEMRDRARAHVD  1305
             EL QE+   LGEE   R R  ++
Sbjct  1072  ELQQEEEQLLGEERETRRRQELE  1094


 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 25/80 (31%), Positives = 45/80 (56%), Gaps = 3/80 (3%)

Query  1223  LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKL  1282
             L++E E L++E  ++    + + + Y ++ Q + QEE +L R++ E  R + +E   +K 
Sbjct  923   LQEEEEELQRE-EREKRRRQEQERQYREEEQLQ-QEEEQLLREEREKRRRQERERQYRKD  980

Query  1283  HELQEKLSPL-GEEMRDRAR  1301
              +LQ+K   L GEE   R R
Sbjct  981   KKLQQKEEQLLGEEPEKRRR  1000


 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 19/56 (33%), Positives = 32/56 (57%), Gaps = 7/56 (12%)

Query  1253  QKKWQEEMELYRQKVEPLRAELQEGARQ-------KLHELQEKLSPLGEEMRDRAR  1301
             +KK++EE EL +++ + LR E ++  RQ       K  ELQ++   L  E R++ R
Sbjct  1004  EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR  1059


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 33/120 (27%), Positives = 52/120 (43%), Gaps = 20/120 (16%)

Query  1209  REQLGPVTQEFWDNLEKETEGLRQEMSKD------------LEEVKAKVQP----YLDDF  1252
             R++ G   ++  D   +E E LRQE  +             LEE K + Q     +++D 
Sbjct  1498  RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE  1557

Query  1253  QK-KWQEEMELYRQKVEPLRAE---LQEGARQKLHELQEKLSPLGEEMRDRARAHVDALR  1308
             Q+ + QE  +  RQ+    R +   LQE   Q+LH  +     L EE + R +     LR
Sbjct  1558  QQLRRQEGQQQLRQEDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR  1617


>gi|45593722|sp|Q86Y07|VRK2_HUMAN  Serine/threonine-protein kinase VRK2 (Vaccinia-related kinase 
2)
Length=508

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 30/111 (27%), Positives = 48/111 (43%), Gaps = 13/111 (11%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANL--NIKIADFGFSNLFTPGQLLKTWCGSPPY  147
            +++  + + H    VH D+KA NLLL       + +AD+G S  + P    K +  +P  
Sbjct  149  RMLDVLEYIHENEYVHGDVKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRK  208

Query  148  AAPELFEGKEYDGPK-------VDIWSLGVVLYVLVCGALPFDGSTLQNLR  191
                  E    D  K        D+  LG  +   +CG LP++    QNL+
Sbjct  209  GHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE----QNLK  255


>gi|71151982|sp|Q7Z406|MYH14_HUMAN  Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin 
heavy chain IIc) (NMHC II-C)
Length=1995

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 32/88 (36%), Positives = 47/88 (53%), Gaps = 13/88 (14%)

Query  1214  PVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAE  1273
             P +Q + D L KE +G RQE    LE++K +    LD    + QE+M   +Q+ E LRA+
Sbjct  1051  PQSQTWRDRLRKEEKG-RQE----LEKLKRR----LDGESSELQEQMVEQQQRAEELRAQ  1101

Query  1274  LQEGARQKLHELQEKLSPLGEEMRDRAR  1301
             L     +K  ELQ  L+   +E   RA+
Sbjct  1102  L----GRKEEELQAALARAEDEGGARAQ  1125


>gi|47115840|sp|Q8N752|KC1AL_HUMAN  Casein kinase I isoform alpha-like (CKI-alpha-like) (CK1)
Length=337

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 12/106 (11%)

Query  90   QIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFGFSNLF--------TPGQLL  138
            Q+++ + + H +N +HRD+K +N L+    +   + + DFG +  +         P +  
Sbjct  119  QMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRED  178

Query  139  KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG  184
            K   G+  YA+     G E    + D+ SLG V       +LP+ G
Sbjct  179  KHLIGTVRYASINAHLGIE-QSRRDDMESLGYVFMYFNRTSLPWQG  223


>gi|50403702|sp|O95613|PCNT_HUMAN  Pericentrin (Pericentrin B) (Kendrin)
Length=3336

 Score = 35.0 bits (79),  Expect = 0.21
 Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 13/117 (11%)

Query  1195  LDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQK  1254
             LD+  +     S+L EQL   T    D LE+  +  + +   +LE+++   +  L D +K
Sbjct  474   LDSARTSRQELSELHEQLLARTSRVED-LEQLKQREKTQHESELEQLRIYFEKKLRDAEK  532

Query  1255  KWQEEMELYRQKVEPLRAELQEGARQK--LHELQEKLSPLG-EEMRDRARA-HVDAL  1307
              +QE++ L +Q++        +GAR+   L  ++  LS +G EE  ++ R  HVD L
Sbjct  533   TYQEDLTLLQQRL--------QGAREDALLDSVEVGLSCVGLEEKPEKGRKDHVDEL  581


 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 4/68 (5%)

Query  1221  DNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQ  1280
             D+LEK    L ++  K+L   K K +    +FQ+K  +    ++   E L+ E +E    
Sbjct  714   DDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETD----WKVMKEELQREAEEKLTL  769

Query  1281  KLHELQEK  1288
              L EL+EK
Sbjct  770   MLLELREK  777


 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 33/134 (24%), Positives = 62/134 (46%), Gaps = 20/134 (14%)

Query  1186  LGKQLNLKLLDNWDSVTSTFSK-LREQLGPVTQEFWD---------NLEKETEGLRQEMS  1235
             L K+L+ K     + + + F K L EQ   + + F D         NLE   +   +++ 
Sbjct  361   LRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKLR  420

Query  1236  KDLEEVKAKVQPYLD----DFQKKWQEEMELYRQKVEPLRAELQEGARQKLHEL------  1285
             +DL+    +    L+    + +K+ Q E+E  +   E L+A+ QE  R+   +L      
Sbjct  421   EDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTS  480

Query  1286  QEKLSPLGEEMRDR  1299
             +++LS L E++  R
Sbjct  481   RQELSELHEQLLAR  494


 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 22/76 (28%), Positives = 40/76 (52%), Gaps = 1/76 (1%)

Query  1224  EKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLH  1283
             + E E LR++ +++ EEV  +      + ++K Q EME   Q V+ L+ + +      L 
Sbjct  300   QHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLE  359

Query  1284  ELQEKLSPLGE-EMRD  1298
              L+++LS   + EM D
Sbjct  360   NLRKELSAKHQSEMED  375


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 3/68 (4%)

Query  1222  NLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK  1281
             NL+KE E    E+ + L   +A+    L   Q + Q E+EL R++    + E+     Q+
Sbjct  268   NLQKEKETALTELREMLNSRRAQELALL---QSRQQHELELLREQHAREKEEVVLRCGQE  324

Query  1282  LHELQEKL  1289
               EL+EKL
Sbjct  325   AAELKEKL  332


>gi|48428484|sp|Q9BXM7|PINK1_HUMAN  Serine/threonine-protein kinase PINK1, mitochondrial precursor 
(PTEN-induced putative kinase protein 1) (BRPK)
Length=581

 Score = 34.7 bits (78),  Expect = 0.28
 Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 16/109 (14%)

Query  101  RNIVHRDLKAENLLLDANLN----IKIADFG--FSNLFTPGQL-LKTWC----GSPPYAA  149
            + I HRDLK++N+L++ + +    + IADFG   ++     QL   +W     G+    A
Sbjct  356  QGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMA  415

Query  150  PELFEGKE-----YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRAR  193
            PE+   +       D  K D W++G + Y +     PF G    +L +R
Sbjct  416  PEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESR  464


>gi|68068057|sp|Q8NHQ8|RASF8_HUMAN  Ras association domain-containing protein 8 (Carcinoma-associated 
protein HOJ-1)
Length=419

 Score = 34.7 bits (78),  Expect = 0.28
 Identities = 21/81 (25%), Positives = 45/81 (55%), Gaps = 10/81 (12%)

Query  1217  QEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQE  1276
             Q++  NLE+E   L Q++ ++  E++          ++ W+ E+++ ++  + L+ +LQE
Sbjct  196   QKYNSNLEEEIVRLEQKIKRNDVEIEE---------EEFWENELQIEQENEKQLKDQLQE  246

Query  1277  GARQKLHELQEKLSPLGEEMR  1297
               RQK+ E + KL     ++R
Sbjct  247   -IRQKITECENKLKDYLAQIR  266


>gi|88909227|sp|Q6WCQ1|MRIP_HUMAN  Myosin phosphatase Rho-interacting protein (Rho-interacting protein 
3) (M-RIP) (RIP3) (p116Rip)
Length=1024

 Score = 34.7 bits (78),  Expect = 0.28
 Identities = 28/118 (23%), Positives = 50/118 (42%), Gaps = 5/118 (4%)

Query  1199  DSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQE  1258
             +   +T S +        +E    LEK        ++ D+E ++ +    L   Q++ + 
Sbjct  762   EETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEV  821

Query  1259  EMELYRQKV--EPLRAELQEGARQKLHELQ---EKLSPLGEEMRDRARAHVDALRTHL  1311
               E Y QK       A+  E  RQ L + Q   ++L+   +E+ +R  A +  LRT L
Sbjct  822   LSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL  879


>gi|62511032|sp|Q6UVJ0|SAS6_HUMAN  Spindle assembly abnormal protein 6 homolog (HsSAS-6)
Length=657

 Score = 34.3 bits (77),  Expect = 0.37
 Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 8/111 (7%)

Query  1188  KQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQP  1247
             K+  L L+ + D  T      R+ L    QE         + LR E +     +  K   
Sbjct  161   KEEKLSLMQSLDDATKQLDFTRKTLAEKKQEL--------DKLRNEWASHTAALTNKHSQ  212

Query  1248  YLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
              L + ++K  +    Y+Q+ E  + +L+   +Q +H+LQ +LS L    +D
Sbjct  213   ELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKD  263


>gi|21759000|sp|Q12955|ANK3_HUMAN  Ankyrin-3 (ANK-3) (Ankyrin G)
Length=4377

 Score = 34.3 bits (77),  Expect = 0.37
 Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 12/91 (13%)

Query  493   PSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTNPTAEIPPDLQRQ  552
             P  L+   P  P+  P+ E S + E +++A    L    K+ T+  T    E+P D+ + 
Sbjct  3186  PDSLIAYIPGKPS--PIPEVSEESEEEEQAKSTSL----KQTTVEETAVEREMPNDVSKD  3239

Query  553   LGQQPFRSRVW------PPHLVPDQHRSTYK  577
               Q+P  +RV       PP L  DQ  S  K
Sbjct  3240  SNQRPKNNRVAYIEFPPPPPLDADQIESDKK  3270


>gi|2493434|sp|Q01082|SPTB2_HUMAN  Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 
1) (Beta-II spectrin) (Fodrin beta chain)
Length=2364

 Score = 34.3 bits (77),  Expect = 0.37
 Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 6/91 (6%)

Query  1199  DSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKK-WQ  1257
             DS + +   +R++L  + Q  W  L +ETE    +  + LEE     Q Y D  + + W 
Sbjct  1554  DSSSLSAEAIRQRLADLKQ-LWGLLIEETE----KRHRRLEEAHRAQQYYFDAAEAEAWM  1608

Query  1258  EEMELYRQKVEPLRAELQEGARQKLHELQEK  1288
              E ELY    E  + E    +  K H++ E+
Sbjct  1609  SEQELYMMSEEKAKDEQSAVSMLKKHQILEQ  1639


>gi|76803557|sp|P11532|DMD_HUMAN  Dystrophin
Length=3685

 Score = 34.3 bits (77),  Expect = 0.37
 Identities = 45/192 (23%), Positives = 84/192 (43%), Gaps = 22/192 (11%)

Query  1200  SVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEE  1259
             SVT  +  + ++LG + Q    +L+++  GL   +S  ++E+  K      +  +K+Q E
Sbjct  968   SVTD-YEIMEQRLGEL-QALQSSLQEQQSGLYY-LSTTVKEMSKKAP---SEISRKYQSE  1021

Query  1260  MELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDelr  1319
              E    + + L ++L E   QKL E   KL  +        + H+  L+  +A     L+
Sbjct  1022  FEEIEGRWKKLSSQLVEHC-QKLEEQMNKLRKI--------QNHIQTLKKWMAEVDVFLK  1072

Query  1320  qrlaarlealkeNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLS  1379
             +   A        G + + +   K    L +  +  +P+L  + +G   +    +  F S
Sbjct  1073  EEWPAL-------GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS  1125

Query  1380  ALEEYTKKLNTQ  1391
              LE   K+LNTQ
Sbjct  1126  RLETELKELNTQ  1137


>gi|41688595|sp|Q9UJC3|HOOK1_HUMAN  Hook homolog 1 (h-hook1) (hHK1)
Length=728

 Score = 33.9 bits (76),  Expect = 0.48
 Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 24/123 (19%)

Query  1200  SVTSTFSKLREQLGPVT-QEFWDNLEKETEGLR-----------QEMSKDLEEVKAKVQP  1247
             S T ++  L  ++ PV  +E +  L+ E + LR           +E+ + LE+   K+  
Sbjct  446   SATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNE  505

Query  1248  YLDDFQKKWQEEMELYRQKVEPLRAELQEGA-----------RQKLHELQEKLSPLGEEM  1296
              L+  Q+  +E +   +Q++E L+  LQE             +QKL    EKL+ + EE+
Sbjct  506   -LETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEEL  564

Query  1297  RDR  1299
             + +
Sbjct  565   QKK  567


>gi|25009466|sp|Q9UIF3|TEKT2_HUMAN  Tektin-2 (Testicular tektin) (Tektin-t) (Testicular tektin B1-like 
protein) (Tektin-B1) (TEKTB1)
Length=430

 Score = 33.9 bits (76),  Expect = 0.48
 Identities = 28/107 (26%), Positives = 52/107 (48%), Gaps = 4/107 (3%)

Query  1207  KLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQE-EMELYRQ  1265
             +LRE     ++  W   EK T     E+ +D+  ++  ++  L   +      E   YR 
Sbjct  268   RLREMEKVYSELKWQ--EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRP  325

Query  1266  KVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLA  1312
              VE  R + Q G   ++H+L+  ++ L +++  +A+  +DAL  HLA
Sbjct  326   NVELCRDQAQYGLTDEVHQLEATIAALKQKLA-QAQDALDALCKHLA  371


>gi|32469766|sp|Q92805|GOGA1_HUMAN  Golgin subfamily A member 1 (Golgin-97)
Length=767

 Score = 33.9 bits (76),  Expect = 0.48
 Identities = 32/135 (23%), Positives = 57/135 (42%), Gaps = 25/135 (18%)

Query  1172  DSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLR  1231
             DSG D+ S  +GS+  + L+ +LL   + +    ++L +    V      NL+K  E L 
Sbjct  40    DSGDDFAS--DGSSSREDLSSQLLRRNEQIRKLEARLSDYAEQVR-----NLQKIKEKLE  92

Query  1232  QEMSKDLEEVKAKVQPYLDDFQ------------------KKWQEEMELYRQKVEPLRAE  1273
               + K  +    K Q   + FQ                  ++W E+M+   ++   L A+
Sbjct  93    IALEKHQDSSMRKFQEQNETFQANRAKMAEGLALALARKDQEWSEKMDQLEKEKNILTAQ  152

Query  1274  LQEGARQKLHELQEK  1288
             LQE   Q ++  Q +
Sbjct  153   LQEMKNQSMNLFQRR  167


>gi|23831094|sp|O00291|HIP1_HUMAN  Huntingtin-interacting protein 1 (HIP-I)
Length=1030

 Score = 33.9 bits (76),  Expect = 0.48
 Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 14/94 (14%)

Query  1205  FSKLREQLGPVTQEFWDNLEKETEGLRQ---------EMSKDLEEVKAKVQPYLDDFQKK  1255
             +SKL+E+   + Q   D L K  E  +Q         ++ ++ +E++  ++   D  Q+K
Sbjct  461   YSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRK  520

Query  1256  WQEEMELYRQKVEPLRAELQEGARQKLHELQEKL  1289
              QE++E+    +E L+ EL    R+ L  LQ  L
Sbjct  521   TQEQLEV----LESLKQELATSQRE-LQVLQGSL  549


>gi|17372543|sp|Q12934|BFSP1_HUMAN  Filensin (Beaded filament structural protein 1) (Lens fiber cell 
beaded-filament structural protein CP 115) (CP115) (Lens 
intermediate filament-like heavy) (LIFL-H)
Length=665

 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 33/121 (27%), Positives = 61/121 (50%), Gaps = 20/121 (16%)

Query  1205  FSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKV-------QPYLDDFQKKWQ  1257
             F +L E  GP      D L ++ E  RQ + +DLE  +A++       Q  LD+F+ K++
Sbjct  75    FQRLGELAGPE-----DALARQVESNRQRV-RDLEAERARLERQGTEAQRALDEFRSKYE  128

Query  1258  EEME---LYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEM---RDRARAHVDALRTHL  1311
              E E   L ++ +E L  E  E     L  LQ +   L +++   +DR + ++  ++T++
Sbjct  129   NECECQLLLKEMLERLNKEADEALLHNL-RLQLEAQFLQDDISAAKDRHKKNLLEVQTYI  187

Query  1312  A  1312
             +
Sbjct  188   S  188


>gi|62899891|sp|Q9HC77|CENPJ_HUMAN  Centromere protein J (Centrosomal P4.1-associated protein) (LAG-3-associated 
protein) (LYST-interacting protein 1)
Length=1338

 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 20/78 (25%), Positives = 45/78 (57%), Gaps = 5/78 (6%)

Query  1224  EKETEGLRQEMSKDLEEVKAKVQPYLDDFQK----KWQEEMELYRQKVEPLRAELQEGAR  1279
             E   E LR+E++ D E+ KAK    +++F+K    K Q+E +++ +     R    +  R
Sbjct  935   ESALEKLRKEIA-DFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKER  993

Query  1280  QKLHELQEKLSPLGEEMR  1297
             +++  L+++++ L E+++
Sbjct  994   EEIQTLKQQIADLREDLK  1011


 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 30/117 (25%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query  1203  STFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKA--KVQPYLDDF-QKKWQEE  1259
             S   KLR+++    Q+    L +  E  ++EM K  +E K   K       F  KK +EE
Sbjct  936   SALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREE  995

Query  1260  MELYRQKVEPLRAELQ----------EGARQKLHELQEKLSPLGEEMRDRARAHVDA  1306
             ++  +Q++  LR +L+             R ++  L  + + L EE++   R  +DA
Sbjct  996   IQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDA  1052


>gi|417031|sp|P32455|GBP1_HUMAN  Interferon-induced guanylate-binding protein 1 (GTP-binding protein 
1) (Guanine nucleotide-binding protein 1) (HuGBP-1)
Length=592

 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 29/138 (21%), Positives = 65/138 (47%), Gaps = 3/138 (2%)

Query  1165  VYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLE  1224
             ++V  L+D  + Y  +       +++    L + +S+T    +  + L    +E    +E
Sbjct  435   LFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEI--EVE  492

Query  1225  KETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAE-LQEGARQKLH  1283
             +      Q  +K L+E++ K +  ++  ++ +QE ++   +K+E  R + L+E  R    
Sbjct  493   RVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLAL  552

Query  1284  ELQEKLSPLGEEMRDRAR  1301
             +LQE+   L E  +  +R
Sbjct  553   KLQEQEQLLKEGFQKESR  570


>gi|1730008|sp|P53804|TTC3_HUMAN  Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR 
repeat protein D)
Length=2025

 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 22/87 (25%), Positives = 46/87 (52%), Gaps = 13/87 (14%)

Query  1203  STFSKLREQLGPVTQEFWDNLEK-------ETEGLRQEMSKDLEE---VKAKVQPYLDDF  1252
             S   K  + L    QE ++N E+       ET  L +++ + LEE    K ++  +L D 
Sbjct  1493  SRIEKEHQVLQDQLQEVYENYEQIKLKGLEETRDLEEKLKRHLEENKISKTELDWFLQDL  1552

Query  1253  Q---KKWQEEMELYRQKVEPLRAELQE  1276
             +   KKWQ+E +  +++++ L+ ++++
Sbjct  1553  EREIKKWQQEKKEIQERLKSLKKKIKK  1579


>gi|29839561|sp|Q8NF91|SYNE1_HUMAN  Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic 
nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope 
protein 1) (Myne-1) (Enaptin)
Length=8797

 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 1/59 (1%)

Query  278   IAECQQLKEERQV-DPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHK  335
             +A C +L+ ++ +   L +D    M D+GL++ Q +Q   SDA  H + +  L+  R K
Sbjct  4388  LAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRK  4446


>gi|30912698|sp|Q8NB25|CF060_HUMAN  Hypothetical protein C6orf60
Length=1020

 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 10/123 (8%)

Query  1183  GSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDL----  1238
             GSA G  L   L D+ + + +     ++ L   T++   N+E E E  RQ+  + +    
Sbjct  447   GSAEG--LIASLQDSQERLQNELDLTKDSLKE-TKDALLNVEGELEQERQQHEETIAAMK  503

Query  1239  EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
             EE K KV     D + KW E +   RQ+   LR EL+    +       +L  L +  ++
Sbjct  504   EEEKLKVDKMAHDLEIKWTENL---RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN  560

Query  1299  RAR  1301
              AR
Sbjct  561   AAR  563


 Score = 33.5 bits (75),  Expect = 0.62
 Identities = 32/133 (24%), Positives = 63/133 (47%), Gaps = 10/133 (7%)

Query  1182  EGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMS---KDL  1238
             E S L ++L L+  ++  S  S   +L+++     ++ W   +K+ E L  ++S   ++L
Sbjct  528   ECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSW---QKKVEDLLNQISLLKQNL  584

Query  1239  EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
             E   ++ Q  L   Q ++ +E +   Q++E    EL+E  +Q+   L+E      + M +
Sbjct  585   EIQLSQSQTSLQQLQAQFTQERQRLTQELE----ELEEQHQQRHKSLKEAHVLAFQTMEE  640

Query  1299  RARAHVDALRTHL  1311
                    AL  HL
Sbjct  641   EKEKEQRALENHL  653


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 24/99 (24%), Positives = 42/99 (42%), Gaps = 2/99 (2%)

Query  239  EHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQV--DPLNED  296
            E L+  + +L  N  + + Q                 RL  E ++L+E+ Q     L E 
Sbjct  571  EDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEA  630

Query  297  VLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHK  335
             +LA + M  +KE+  ++L +     +SA    L D H+
Sbjct  631  HVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHR  669


>gi|14195007|sp|Q15149|PLEC1_HUMAN  Plectin 1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1)
Length=4684

 Score = 33.1 bits (74),  Expect = 0.82
 Identities = 36/130 (27%), Positives = 57/130 (43%), Gaps = 20/130 (15%)

Query  1175  RDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEM  1234
             R+ +++ E      Q   KLL        T  +  EQL   TQ    +   E + L Q  
Sbjct  2586  REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKDSLLQR-  2642

Query  1235  SKDLEEVKAKVQPYLDDF----------QKKWQEEMELYRQKV----EPLRA---ELQEG  1277
              + +E+ KAK++    D           Q++ Q++ME  RQ++    E  R    E +EG
Sbjct  2643  ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG  2702

Query  1278  ARQKLHELQE  1287
              R+K  ELQ+
Sbjct  2703  VRRKQEELQQ  2712


 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 30/118 (25%), Positives = 58/118 (49%), Gaps = 11/118 (9%)

Query  1193  KLLDNWDSVTSTFSKLREQL------GPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQ  1246
             KL    ++   TF  LR++L      G   Q+     + E E  R+ +++ LE  +A V 
Sbjct  1271  KLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA-VL  1329

Query  1247  PYLDDFQKKWQE---EMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR  1301
                D  Q++ ++   ++  YR+  +PL A LQ+ AR++  ++Q       + +R++ R
Sbjct  1330  AQTDVRQRELEQLGRQLRYYRESADPLGAWLQD-ARRRQEQIQAMPLADSQAVREQLR  1386


>gi|47606000|sp|Q15276|RABE1_HUMAN  Rab GTPase binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) 
(Rabaptin-4)
Length=862

 Score = 33.1 bits (74),  Expect = 0.82
 Identities = 25/89 (28%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query  1207  KLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQK  1266
             KLR  + P+ +E     +K TE   ++  K+LE  K K   +  + +K  + ++E+Y   
Sbjct  183   KLRSVVMPMEKEIAALKDKLTEA--EDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAV  240

Query  1267  VEPLRAELQEGARQKLHELQEKLSPLGEE  1295
             +   ++ LQE A +   EL E    L +E
Sbjct  241   LNTQKSVLQEDAEKLRKELHEVCHLLEQE  269


 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 39/145 (26%), Positives = 66/145 (45%), Gaps = 14/145 (9%)

Query  1173  SGRDYVSQFEGSALGKQLNL--KLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGL  1230
             SG   VS+ E + L K+++     L     + S + K  + +     E  D ++K    L
Sbjct  505   SGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLML  564

Query  1231  RQEMSKDLEEVKAKVQPYLDDFQKKWQEE-------MELYRQKVEPLRAELQEGARQKLH  1283
             RQ  + D  E   K +  L+DF K+  E+       + L  Q  E L  ELQ+G  Q   
Sbjct  565   RQ--ANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKR  622

Query  1284  ELQEKLSPLGEEMRDRARAHVDALR  1308
             ++QE+++ L   M+ R +   + +R
Sbjct  623   DVQEQMAVL---MQSREQVSEELVR  644


>gi|84029264|sp|Q3T8J9|GON4_HUMAN  Protein GON4 (GON-4 homolog) (GON-4-like protein)
Length=2241

 Score = 33.1 bits (74),  Expect = 0.82
 Identities = 31/123 (25%), Positives = 48/123 (39%), Gaps = 12/123 (9%)

Query  917   LQQALLSPTPPDYTRHQQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLL  976
             +Q++L +PTP D    ++   M  E   E+ S    +D   D K    +          L
Sbjct  1309  IQESLNNPTPGDL---EEIVKMEPEEAREEISGSPERDICDDIKVEHAVE---------L  1356

Query  977   STGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVE  1036
              TG P +  S  G V+    L       QPT   S ++ P  E   G  +++ S   A+ 
Sbjct  1357  DTGAPSEELSSAGEVTKQTVLQKEEERSQPTKTPSSSQEPPDEGTSGTDVNKGSSKNALS  1416

Query  1037  LPD  1039
               D
Sbjct  1417  SMD  1419


>gi|62288025|sp|Q66GS9|CEP4_HUMAN  Centrosomal protein 4 (Centrosomal protein of 135 kDa) (Cep135 
protein)
Length=1140

 Score = 33.1 bits (74),  Expect = 0.82
 Identities = 35/150 (23%), Positives = 69/150 (46%), Gaps = 24/150 (16%)

Query  1165  VYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWD---  1221
             + VD L+ + +D         L K++  +L++  ++VTS    L  +   + QE  +   
Sbjct  275   IQVDFLQQANKD---------LEKRIR-ELMETKETVTSEVVNLSNKNEKLCQELTEIDQ  324

Query  1222  ---NLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQ------KKWQEEMELYRQKVEPLRA  1272
                 LE+  E L +   K+L E K +++  L + Q       K Q E+ L +++ E L  
Sbjct  325   LAQQLERHKEELLETADKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSD  384

Query  1273  EL--QEGARQKLHELQEKLSPLGEEMRDRA  1300
             EL  +      +H+L+++   L +++   A
Sbjct  385   ELLVKSDLETVVHQLEQEKQRLSKKVESFA  414


>gi|12643718|sp|Q13439|GOGA4_HUMAN  Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) 
(Golgin-245) (Protein 72.1)
Length=2230

 Score = 33.1 bits (74),  Expect = 0.82
 Identities = 29/122 (23%), Positives = 60/122 (49%), Gaps = 11/122 (9%)

Query  1201  VTSTFSKLREQLGPVTQEFWDNLEK------ETEGLRQEMSKDLEEVKAKVQPYLDDFQK  1254
             +T+   +LREQ     +  ++ LEK      +TE  R+++  +++E    ++   ++ + 
Sbjct  394   MTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI  453

Query  1255  KWQEEMELYRQKVEPL---RAELQEGARQKLH--ELQEKLSPLGEEMRDRARAHVDALRT  1309
               Q+E+   +Q+V  +    +E Q    QKLH  EL  K   L ++++ R R   + ++ 
Sbjct  454   SLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKV  513

Query  1310  HL  1311
              L
Sbjct  514   AL  515


 Score = 32.7 bits (73),  Expect = 1.1
 Identities = 25/124 (20%), Positives = 61/124 (49%), Gaps = 4/124 (3%)

Query  1167  VDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKE  1226
             VDV+K S  + +++ +     K+L  K  +    + +   + +EQ+    ++      K 
Sbjct  467   VDVMKKSSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKI  525

Query  1227  TEGLRQEMSKDLEEVKAKVQPYLDDFQKKW---QEEMELYRQKVEPLRAELQEGARQKLH  1283
             ++   Q+ S  LEE++ + +  L + + K    Q+E E YR ++  L + L++  ++  +
Sbjct  526   SQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN  585

Query  1284  ELQE  1287
             + ++
Sbjct  586   QSKD  589


 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 22/89 (24%), Positives = 42/89 (47%), Gaps = 4/89 (4%)

Query  1223  LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMEL-YRQKVEPLRAELQEGARQK  1281
             L+K+   LR+E  ++LE +K +     ++  K+ QE++EL +   ++ L  E      QK
Sbjct  1949  LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK  2008

Query  1282  LHELQEKLSPLGEEMRDRARAHVDALRTH  1310
               EL+  +    E +        + L +H
Sbjct  2009  EQELEMTIK---ETINKAQEVEAELLESH  2034


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 28/111 (25%), Positives = 55/111 (49%), Gaps = 10/111 (9%)

Query  1189  QLNLKLLDNWDS---VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKV  1245
             QL  KLLD       +T   +++  Q   V  E  D  + + + L Q++ K   E++ KV
Sbjct  823   QLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL-DAHKIQVQDLMQQLEKQNSEMEQKV  881

Query  1246  QPYLDDFQKKWQE---EMELYRQ---KVEPLRAELQEGARQKLHELQEKLS  1290
             +     ++ K ++   E E  +Q   + E +  +++EG ++++  L +KLS
Sbjct  882   KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS  932


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 31/134 (23%), Positives = 66/134 (49%), Gaps = 6/134 (4%)

Query  1160  KDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDN-WDSVTSTFSKLREQLGPVTQE  1218
             KD+ T  +D  K   +D + Q E      +  +K L   ++S     +K +EQ   +  E
Sbjct  850   KDVCTE-LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE  908

Query  1219  FWDNLEKETEGLRQEMSKDLEEVKAK---VQPYLDDFQKKWQEEMELYRQKVEPLRAELQ  1275
               + + +  EG ++E+    +++ AK   +    ++++ K++ + E   +KV+    E+Q
Sbjct  909   KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ-EKKMEKVKQKAKEMQ  967

Query  1276  EGARQKLHELQEKL  1289
             E  ++KL + + KL
Sbjct  968   ETLKKKLLDQEAKL  981


>gi|56405385|sp|Q9HCM9|TRI39_HUMAN  Tripartite motif protein 39 (RING finger protein 23) (Testis-abundant 
finger protein)
Length=518

 Score = 32.7 bits (73),  Expect = 1.1
 Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 10/99 (10%)

Query  1212  LGPVTQEFWDNLEKETEGLRQEMS----------KDLEEVKAKVQPYLDDFQKKWQEEME  1261
             L   TQE+ + L+K  E L Q++           K   E+K  V+       ++++E   
Sbjct  143   LDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHR  202

Query  1262  LYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRA  1300
                ++ + L + L+E  +  L  L+E  + LG++ RD A
Sbjct  203   RLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLA  241


>gi|50401687|sp|Q9NVA2|SEP11_HUMAN  Septin-11
Length=429

 Score = 32.7 bits (73),  Expect = 1.1
 Identities = 19/61 (31%), Positives = 35/61 (57%), Gaps = 1/61 (1%)

Query  1239  EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
             E  +AK   +L + QKK +E  +++  +V+   AEL+E A ++LHE  + L    +E + 
Sbjct  321   ETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKE-AEKELHEKFDLLKRTHQEEKK  379

Query  1299  R  1299
             +
Sbjct  380   K  380


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 11/76 (14%)

Query  1208  LREQLGPVTQEFWDNLEKETEGLRQ-------EMSKDLEEVKAKVQPYLDDFQKKWQEEM  1260
             L+E       EF   L+K+ E +RQ       E   +L+E + ++    D  ++  QEE 
Sbjct  319   LQETYEAKRNEFLGELQKKEEEMRQMFVMRVKEKEAELKEAEKELHEKFDLLKRTHQEE-  377

Query  1261  ELYRQKVEPLRAELQE  1276
                ++KVE  + EL+E
Sbjct  378   ---KKKVEDKKKELEE  390


>gi|547754|sp|P35908|K22E_HUMAN  Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (K2e) 
(CK 2e)
Length=645

 Score = 32.7 bits (73),  Expect = 1.1
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 6/113 (5%)

Query  1188  KQLNLKLLDNWDSVTSTFSKLRE-QLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQ  1246
             +Q N  L   W+ +       R   L P+ Q + D+L++  +GL  E +    E+   +Q
Sbjct  206   EQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYIDSLKRYLDGLTAERTSQNSELN-NMQ  264

Query  1247  PYLDDFQKKWQEEME---LYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEM  1296
               ++D++KK+++E+            L+ ++      K+ ELQ K+  L +E+
Sbjct  265   DLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKV-ELQSKVDLLNQEI  316


>gi|84027766|sp|Q5VTR2|BRE1A_HUMAN  Ubiquitin ligase protein BRE1A (BRE1-A) (RING finger protein 
20)
Length=975

 Score = 32.7 bits (73),  Expect = 1.1
 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 8/86 (9%)

Query  1232  QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHE------L  1285
             +EM+ +LEE K   Q  L + +K  Q+  E+  Q  E L+ EL+    Q + E      +
Sbjct  326   EEMNAELEENKELAQNRLCELEKLRQDFEEVTTQN-EKLKVELRSAVEQVVKETPEYRCM  384

Query  1286  QEKLSPLGEEMRDRARAHVDALRTHL  1311
             Q + S L  E   + +AH+D  RT L
Sbjct  385   QSQFSVLYNESL-QLKAHLDEARTLL  409


>gi|28201804|sp|Q14789|GOGB1_HUMAN  Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa 
Golgi complex-associated protein) (GCP372)
Length=3259

 Score = 32.7 bits (73),  Expect = 1.1
 Identities = 24/88 (27%), Positives = 47/88 (53%), Gaps = 12/88 (13%)

Query  1194  LLDNWDSVTSTFSKLREQLGPVTQE---FWDNL------EKETEGLRQEMSKDLEEVKAK  1244
             LL ++++V++   +++  +  V QE    +  L      +KETE   QE  +++EE+K K
Sbjct  1618  LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK  1677

Query  1245  VQPYLDDFQKK---WQEEMELYRQKVEP  1269
             ++ +    Q+K    +EE +  R +V P
Sbjct  1678  MRKFAKSKQQKILELEEENDRLRAEVHP  1705


>gi|12643528|sp|O00311|CDC7_HUMAN  Cell division cycle 7-related protein kinase (CDC7-related kinase) 
(HsCdc7) (huCdc7)
Length=574

 Score = 32.7 bits (73),  Expect = 1.1
 Identities = 14/40 (35%), Positives = 21/40 (52%), Gaps = 0/40 (0%)

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF  182
            G+P + APE+          +D+WS GV+   L+ G  PF
Sbjct  375  GTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF  414


>gi|266902|sp|P30622|REST_HUMAN  Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg 
intermediate filament associated protein) (Cytoplasmic 
linker protein 1)
Length=1427

 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 21/110 (19%), Positives = 55/110 (50%), Gaps = 14/110 (12%)

Query  1188  KQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFW---DNLEKETEGLRQEMSKDLEEVKAK  1244
             ++L +       + T+ F++L+ Q+  +  ++    +NL+ + +  R   +K++E ++AK
Sbjct  628   EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAK  687

Query  1245  VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGE  1294
             +   + + +             +E +R++L +   Q L E+++ L+ L E
Sbjct  688   LMKVIKEKE-----------NSLEAIRSKLDKAEDQHLVEMEDTLNKLQE  726


 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 9/154 (5%)

Query  1145  FWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTST  1204
             F ++DE  +      + L     +++K SG D  SQ   + +  +L LK  D  + +   
Sbjct  898   FREKDEREEQLIKAKEKLENDIAEIMKMSG-DNSSQL--TKMNDELRLKERDV-EELQLK  953

Query  1205  FSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR  1264
              +K  E      Q+  +++  + E  +QE +K  EE K +++  L D +KK    ME   
Sbjct  954   LTKANENAS-FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKK----METSH  1008

Query  1265  QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
              + + L+A  +    +   + +E L  L + + D
Sbjct  1009  NQCQELKARYERATSETKTKHEEILQNLQKTLLD  1042


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 42/204 (20%), Positives = 86/204 (42%), Gaps = 23/204 (11%)

Query  1196  DNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGL--RQEMSKDLEEVKAKVQPYLDDFQ  1253
             + ++ ++S   KLRE L  +  +F +  E+E + +  ++++  D+ E+  K+        
Sbjct  875   EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI-MKMSGDNSSQL  933

Query  1254  KKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPL----GEEMRDRARAHVDALRT  1309
              K  +E+ L  + VE L+ +L + A +    LQ+ +  +     +  ++ A+ H +  + 
Sbjct  934   TKMNDELRLKERDVEELQLKLTK-ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE  992

Query  1310  HLAPYSDelrqrlaarlealkeNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPV  1369
                  SD        +      N    L   + +AT    T   K +  L++L++ LL  
Sbjct  993   LERKLSD------LEKKMETSHNQCQELKARYERATSETKT---KHEEILQNLQKTLLDT  1043

Query  1370  LESFK------VSFLSALEEYTKK  1387
              +  K         L  LEE  K+
Sbjct  1044  EDKLKGAREENSGLLQELEELRKQ  1067


>gi|20138952|sp|Q15025|NAF1_HUMAN  Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) 
(HIV-1 Nef-interacting protein) (Virion-associated nuclear 
shuttling protein) (VAN) (hVAN) (Nip40-1)
Length=636

 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 24/75 (32%), Positives = 44/75 (58%), Gaps = 7/75 (9%)

Query  1224  EKETEGLRQEMS---KDLEEVKAKVQPYLDDFQKKW---QEEMELYRQKVEPLRAELQEG  1277
             E++   LRQ+++   K + +++A+ +    DF +K    + ++E+     E L AE +E 
Sbjct  332   EQKITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKE-  390

Query  1278  ARQKLHELQEKLSPL  1292
              RQK+  LQ++LSPL
Sbjct  391   LRQKVKYLQDQLSPL  405


 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 27/106 (25%)

Query  1231  RQEMSKDLEEVKAKVQPYLDDFQK------KWQEEMELYRQKVEPLRAEL----------  1274
             +QE+    E +K +V+ + +DFQ+      +  EE E  +++VE L+A++          
Sbjct  452   KQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAF  511

Query  1275  --QEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLA---PYS  1315
               +E AR+ L + + K    GE      R HV+    HL    PY+
Sbjct  512   KDEEKAREALRQQKRKAKASGE------RYHVEPHPEHLCGAYPYA  551


>gi|3041707|sp|P13535|MYH8_HUMAN  Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)
Length=1937

 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 39/132 (29%), Positives = 69/132 (52%), Gaps = 21/132 (15%)

Query  1196  DNWDSVTSTFSKLREQL----GPVTQEF-----WDNLEKETEG---LRQEMSKDLEEVKA  1243
             D  + +T   +KL +Q+    G + QE       +  +++ EG   L QE + D+E  K 
Sbjct  1018  DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ  1077

Query  1244  KVQPYLDDFQKKWQEEMELYRQKVEPLRA-ELQEGARQKLHELQEKLSPLGEEMR-DRA-  1300
             +    LD+  +K + E+     K+E  +A E+Q   ++K+ ELQ ++  LGEE+  +RA 
Sbjct  1078  Q----LDEKLEKKEFEISNLISKIEDEQAVEIQ--LQKKIKELQARIEELGEEIEAERAS  1131

Query  1301  RAHVDALRTHLA  1312
             RA  +  R+ L+
Sbjct  1132  RAKAEKQRSDLS  1143


 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 33/134 (24%), Positives = 57/134 (42%), Gaps = 28/134 (20%)

Query  1195  LDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEG----------------LRQEMSKDL  1238
             LD  D++ S  S+ ++      +E    LE+ET+                 L +E  ++ 
Sbjct  1294  LDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEE  1353

Query  1239  EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
             +E KA++Q  L     K   E+  +R K E         A Q+  EL+E    L + +++
Sbjct  1354  QEGKAELQRAL----SKANSEVAQWRTKYE-------TDAIQRTEELEEAKKKLAQRLQE  1402

Query  1299  RARAHVDALRTHLA  1312
              A  HV+A+    A
Sbjct  1403  -AEEHVEAVNAKCA  1415


>gi|68068009|sp|P49756|RBM25_HUMAN  Probable RNA-binding protein 25 (RNA-binding motif protein 25) 
(RNA-binding region containing protein 7) (Protein S164)
Length=784

 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 32/137 (23%), Positives = 57/137 (41%), Gaps = 8/137 (5%)

Query  1171  KDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGL  1230
             KD  RD     E +   ++L  KL +   +          +    T+E+    E+E E  
Sbjct  368   KDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEER-  426

Query  1231  RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS  1290
             R+EM+K+ + +K  ++ Y DD            ++++     E++   R +  E +E   
Sbjct  427   RREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEEL--  484

Query  1291  PLGEEMRDR--ARAHVD  1305
                EE+R R  A  H D
Sbjct  485   ---EEIRQRLLAEGHPD  498


>gi|71153344|sp|Q96KP6|TNIP3_HUMAN  TNFAIP3-interacting protein 3 (Listeria-induced gene protein) 
(A20-binding inhibitor of NF-kappa B activation 3) (ABIN-3)
Length=319

 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 17/66 (25%), Positives = 37/66 (56%), Gaps = 2/66 (3%)

Query  1224  EKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLH  1283
             +   E   +EM  ++E +K +VQ Y +DF+K+  +   L ++K E    ++ E ++ +L+
Sbjct  183   KSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEE--LQQINETSQSQLN  240

Query  1284  ELQEKL  1289
              L  ++
Sbjct  241   RLNSQI  246


>gi|20532393|sp|O15230|LAMA5_HUMAN  Laminin alpha-5 chain precursor
Length=3695

 Score = 32.3 bits (72),  Expect = 1.4
 Identities = 26/92 (28%), Positives = 47/92 (51%), Gaps = 7/92 (7%)

Query  1222  NLEKETEGL--RQEMSKDLEEVKAKVQPYLDDFQKKWQ--EEMELYRQKVEPLRAELQEG  1277
             N E+  E L  +QE+S+D   ++A +    D     ++    ++  ++++E L A L +G
Sbjct  2405  NQERLEEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASL-DG  2463

Query  1278  ARQKLHELQEKLSPLGEEMR--DRARAHVDAL  1307
             AR  L +  +  SP G ++R  + A AH   L
Sbjct  2464  ARTPLLQRMQTFSPAGSKLRLVEAAEAHAQQL  2495


>gi|48474671|sp|Q9NSB2|KRHB4_HUMAN  Keratin, type II cuticular Hb4 (Hair keratin, type II Hb4)
Length=600

 Score = 32.0 bits (71),  Expect = 1.8
 Identities = 19/68 (27%), Positives = 37/68 (54%), Gaps = 1/68 (1%)

Query  1193  KLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDF  1252
             KLL+   S       +R  L P+ + +  NL ++ E L  + ++ L+  +  +Q  L+ F
Sbjct  191   KLLETKWSFLQEQKCIRSNLEPLFESYITNLRRQLEVLVSDQAR-LQAERNHLQDVLEGF  249

Query  1253  QKKWQEEM  1260
             +KK++EE+
Sbjct  250   KKKYEEEV  257


>gi|67472134|sp|Q86YS3|RFIP4_HUMAN  Rab11 family-interacting protein 4 (Rab11-FIP4)
Length=637

 Score = 32.0 bits (71),  Expect = 1.8
 Identities = 22/92 (23%), Positives = 46/92 (50%), Gaps = 7/92 (7%)

Query  1223  LEKETEGLR------QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQE  1276
             LE+E   LR      +  ++ L+E + ++   L+D   + ++EM+LY++ ++ LR    E
Sbjct  429   LEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLE  488

Query  1277  GARQKLHELQEKLSPLGEEMRDRARAHVDALR  1308
               +++    QE +  L +E+       +D  R
Sbjct  489   FQKER-EATQELIEDLRKELEHLQMYKLDCER  519


>gi|56405387|sp|Q9UPN3|MACF1_HUMAN  Microtubule-actin crosslinking factor 1, isoforms 1/2/3/5 (Actin 
cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) 
(620 kDa actin-binding protein) (ABP620)
Length=5430

 Score = 32.0 bits (71),  Expect = 1.8
 Identities = 33/140 (23%), Positives = 61/140 (43%), Gaps = 18/140 (12%)

Query  1169  VLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEK---  1225
             VL++     + Q+E  +L        L+    + + F +  E+L P  +E    + +   
Sbjct  3791  VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPS  3850

Query  1226  ---ETEGLRQEMS--KDLEEVKAKVQPYLDDFQK----------KWQEEMELYRQKVEPL  1270
                + E LRQ+    + L E  A+ +P++D   K          +  E +E   QK E +
Sbjct  3851  PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM  3910

Query  1271  RAELQEGARQKLHELQEKLS  1290
              A+++E  RQ+   L E +S
Sbjct  3911  YAQIKEEVRQRALALDEAVS  3930


 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 29/128 (22%), Positives = 62/128 (48%), Gaps = 10/128 (7%)

Query  1188  KQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQE------MSKDLEEV  1241
             K  ++ ++ + DS+   FS   E  G   +E    L+++TE L Q+      ++ +    
Sbjct  3757  KAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYAR  3816

Query  1242  KAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGA--RQKLHELQEKLSPLGEEMRDR  1299
               + Q  ++ F + + EE+  + ++   L A+L   A   ++L + QE++  L E + + 
Sbjct  3817  LERAQVLVNQFWETY-EELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH  3875

Query  1300  ARAHVDAL  1307
              + H+D L
Sbjct  3876  -KPHIDKL  3882


>gi|29337005|sp|Q9UQE7|SMC3_HUMAN  Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 
6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) 
(Basement membrane-associated chondroitin proteoglycan)
Length=1217

 Score = 32.0 bits (71),  Expect = 1.8
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 28/100 (28%)

Query  1222  NLEKETEGLRQEMSK----------DLEEVKAKVQPYLDDFQKKWQE-----EMELYRQK  1266
             +L KETEG R+++++           LEE K ++  Y     +KW +     E  +Y Q+
Sbjct  177   SLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY-----QKWDKMRRALEYTIYNQE  231

Query  1267  VEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDA  1306
             +   RA        KL EL  K    GE+ R    A  DA
Sbjct  232   LNETRA--------KLDELSAKRETSGEKSRQLRDAQQDA  263


>gi|23503070|sp|Q06547|GABP2_HUMAN  GA binding protein beta chain (GABP-beta-2 subunit) (GABP-2) 
(GABP-beta-1 subunit) (GABPB-1) (Transcription factor E4TF1-53) 
(Transcription factor E4TF1-47) (Nuclear respiratory factor 
2)
Length=395

 Score = 32.0 bits (71),  Expect = 1.8
 Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 10/96 (10%)

Query  1184  SALGKQLNLKLLDNWDSVTSTFSKLREQL-----GPVTQEFWDNLEKETEGL----RQEM  1234
             S +G+ + + + D    +T   + + E+       P  ++  + +E   E      R+ +
Sbjct  291   SGIGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL  350

Query  1235  SKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPL  1270
              K L+E   + Q Y     KK ++E E YRQK+E +
Sbjct  351   QKQLDEANREAQKYRQQLLKK-EQEAEAYRQKLEAM  385


>gi|30316105|sp|Q96PK2|MACF4_HUMAN  Microtubule-actin crosslinking factor 1, isoform 4
Length=5938

 Score = 32.0 bits (71),  Expect = 1.8
 Identities = 33/140 (23%), Positives = 61/140 (43%), Gaps = 18/140 (12%)

Query  1169  VLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEK---  1225
             VL++     + Q+E  +L        L+    + + F +  E+L P  +E    + +   
Sbjct  4293  VLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPS  4352

Query  1226  ---ETEGLRQEMS--KDLEEVKAKVQPYLDDFQK----------KWQEEMELYRQKVEPL  1270
                + E LRQ+    + L E  A+ +P++D   K          +  E +E   QK E +
Sbjct  4353  PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENM  4412

Query  1271  RAELQEGARQKLHELQEKLS  1290
              A+++E  RQ+   L E +S
Sbjct  4413  YAQIKEEVRQRALALDEAVS  4432


 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 29/128 (22%), Positives = 62/128 (48%), Gaps = 10/128 (7%)

Query  1188  KQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQE------MSKDLEEV  1241
             K  ++ ++ + DS+   FS   E  G   +E    L+++TE L Q+      ++ +    
Sbjct  4259  KAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYAR  4318

Query  1242  KAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGA--RQKLHELQEKLSPLGEEMRDR  1299
               + Q  ++ F + + EE+  + ++   L A+L   A   ++L + QE++  L E + + 
Sbjct  4319  LERAQVLVNQFWETY-EELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEH  4377

Query  1300  ARAHVDAL  1307
              + H+D L
Sbjct  4378  -KPHIDKL  4384


>gi|6136547|sp|O60299|Y0552_HUMAN  Hypothetical protein KIAA0552
Length=673

 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 24/86 (27%), Positives = 40/86 (46%), Gaps = 12/86 (13%)

Query  1217  QEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYR-------QKVEP  1269
             +  W+  E+E   LR    + LE+ +A V   L++ QK W+ E+   R       Q+V  
Sbjct  326   ERLWEK-EQEVAALR----RSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR  380

Query  1270  LRAELQEGARQKLHELQEKLSPLGEE  1295
                  Q+G + ++  LQ+    L EE
Sbjct  381   RAQRAQQGLQLQVLRLQQDKKQLQEE  406


>gi|23396633|sp|Q15058|KIF14_HUMAN  Kinesin-like protein KIF14
Length=1648

 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 1/77 (1%)

Query  1230  LRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAEL-QEGARQKLHELQEK  1288
             +++   K  EE+   +Q   +  Q++   +   Y  K++ L AEL +E  R+K+ E+  +
Sbjct  943   IKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQ  1002

Query  1289  LSPLGEEMRDRARAHVD  1305
              +    E  ++A+ H++
Sbjct  1003  KANHKIEELEKAKQHLE  1019


>gi|32470610|sp|Q08378|GOGA3_HUMAN  Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated 
protein of 170 kDa) (GCP170)
Length=1498

 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 7/90 (7%)

Query  1223  LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKL  1282
             LEKE + +    S++LEE + KV    D+ Q     E   +R+K++ L    ++ A +  
Sbjct  1061  LEKELQEVIALTSQELEESREKVLELEDELQ-----ESRGFRKKIKRLEESNKKLALELE  1115

Query  1283  HELQEKLSPLGEEMRDRARAHVDALRTHLA  1312
             HE + KL+ LG+      R H   L T LA
Sbjct  1116  HE-KGKLTGLGQS-NAALREHNSILETALA  1143


>gi|1350802|sp|Q05823|RN5A_HUMAN  2-5A-dependent ribonuclease (2-5A-dependent RNase) (Ribonuclease 
L) (RNase L) (Ribonuclease 4)
Length=741

 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 24/108 (22%)

Query  84   ARRKFKQIVTAVYFCHCR-NIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWC  142
            AR     I  AV   H      H+DL+ +N+L+D+     +ADF  S           W 
Sbjct  461  ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS---------IKWA  511

Query  143  GSPPYAAPELFEGKEYDGPKVDIWSLG-VVLYVLVCGALPFDGSTLQN  189
            G P                K D+  LG +VLYV+  G++ F+    Q+
Sbjct  512  GDPQEV-------------KRDLEDLGRLVLYVVKKGSISFEDLKAQS  546


>gi|61223942|sp|Q9UBC2|EP15R_HUMAN  Epidermal growth factor receptor substrate 15-like 1 (Eps15-related 
protein) (Eps15R)
Length=864

 Score = 31.6 bits (70),  Expect = 2.4
 Identities = 21/99 (21%), Positives = 54/99 (54%), Gaps = 18/99 (18%)

Query  1217  QEFWDNLEKETEGLR---------QEMSKDLEEVKAKVQPYLDDFQKKWQEEMEL---YR  1264
             QE  ++L++ET  L+         Q+   ++++ KAK++  L D ++K Q+E ++    +
Sbjct  422   QELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLK  481

Query  1265  QKVEPLRAELQ------EGARQKLHELQEKLSPLGEEMR  1297
              +++   ++L+        A+ +L+ LQ++ + L + ++
Sbjct  482   TQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQ  520


>gi|60392986|sp|Q92878|RAD50_HUMAN  DNA repair protein RAD50 (hRAD50)
Length=1312

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 28/119 (23%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query  1189  QLNLKLLDNWDS----VTSTFSKLREQLGPVTQEFW--DNLEKETEGLRQEMS---KDLE  1239
             +LN KL+ +       + ST ++L+ +   ++        LE++T  L  E+    ++++
Sbjct  847   ELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIK  906

Query  1240  EVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD  1298
             + K +V P     +K  QE+ EL  +K    +      A+ KL++++EK+  +   M+D
Sbjct  907   DAKEQVSPLETTLEKFQQEKEELINKKNTSNKI-----AQDKLNDIKEKVKNIHGYMKD  960


>gi|8134814|sp|Q9UPW0|FOXJ3_HUMAN  Forkhead box protein J3
Length=622

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 50/180 (27%), Positives = 70/180 (38%), Gaps = 31/180 (17%)

Query  956   FQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGH-QPTAAFSKNK  1014
             +Q S SS+  T    +   L ++ G G   +  G+ S AQ    HP  H QP+       
Sbjct  330   YQHSPSSTVSTHPHSNQSSLSNSHGSG--LNTTGSNSVAQVSLSHPQMHPQPSPH-----  382

Query  1015  VPSREPVIGNCMDRSSPGQAVELPDHNGLG--YPARPSVHEHHRPRALQRHHTIQN----  1068
              P   P       + SP  A     H+ L   +P  PS H+H +     +H T+ +    
Sbjct  383   -PPHRPHGLPQHPQRSPHPAPHPQQHSQLQSPHPQHPSPHQHIQHHPNHQHQTLTHQAPP  441

Query  1069  -----------SDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQ-SSLMGSQQFQDGEN  1116
                        S+D Y  LD L     +A    SS   SD  LSQ   LM S +  D +N
Sbjct  442   PPQQVSCNSGVSNDWYATLDMLKESCRIA----SSVNWSDVDLSQFQGLMESMRQADLKN  497


>gi|3913957|sp|O14782|KIF3C_HUMAN  Kinesin-like protein KIF3C
Length=793

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 2/78 (2%)

Query  1223  LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQ--EGARQ  1280
             LEK  E   QE  + LEE KA +Q       ++ Q+ +E   + +E LR E Q  E    
Sbjct  453   LEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAA  512

Query  1281  KLHELQEKLSPLGEEMRD  1298
             K   ++ KL   G  + D
Sbjct  513   KYKAMESKLLIGGRNIMD  530


>gi|62286590|sp|O94986|CE152_HUMAN  Centrosomal protein of 152 kDa (Cep152 protein)
Length=1275

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 20/69 (28%), Positives = 38/69 (55%), Gaps = 5/69 (7%)

Query  1241  VKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRA  1300
             V  ++   + + ++KW+ E+E  R+ + P + EL+E    K+H LQ++L    EE+    
Sbjct  802   VNKRISFAVSEAKEKWKSELENMRKNILPGK-ELEE----KIHSLQKELELKNEEVPVVI  856

Query  1301  RAHVDALRT  1309
             RA +   R+
Sbjct  857   RAELAKARS  865


>gi|2498313|sp|Q16643|DREB_HUMAN  Drebrin (Developmentally regulated brain protein)
Length=649

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 14/114 (12%)

Query  1189  QLNLKLLDNWDSVTSTFSKLR---EQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKV  1245
             +L L+  +N + V +T+ K     E      ++FW+  +KE     +E+ K+ E  KA  
Sbjct  147   RLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKE-----EELRKEEERKKA--  199

Query  1246  QPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDR  1299
                LD+  +  QE ME  RQ+ E      +E   Q++ E + K   L  E   R
Sbjct  200   ---LDERLRFEQERMEQERQEQEERERRYRE-REQQIEEHRRKQQTLEAEEAKR  249


>gi|17367904|sp|O15020|SPTN2_HUMAN  Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 
2) (Beta-III spectrin)
Length=2390

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 6/93 (6%)

Query  1217  QEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKK-WQEEMELYRQKVEPLRAELQ  1275
             QE W  L  E E LR    K LE+     Q Y D  + + W  E EL+    E  + EL 
Sbjct  1567  QEMWKRLGHELE-LR---GKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELS  1622

Query  1276  EGARQKLHE-LQEKLSPLGEEMRDRARAHVDAL  1307
               A  K H+ L++ L+   + +   A +  D +
Sbjct  1623  AQAEVKKHQVLEQALADYAQTIHQLAASSQDMI  1655


>gi|68565596|sp|Q8IZL2|MAML2_HUMAN  Mastermind-like protein 2 (Mam-2)
Length=1153

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 23/81 (28%), Positives = 31/81 (38%), Gaps = 9/81 (11%)

Query  900  TFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQPALMHSESMEEDCSCEGAKDGFQDS  959
            T PP     PP  + +A   A   P PPDY  H Q  L++S       S  G   G    
Sbjct  103  TAPPPPPAAPPAASQAAATAA--PPPPPDYHHHHQQHLLNS-------SNNGGSGGINGE  153

Query  960  KSSSTLTKGCHDSPLLLSTGG  980
            +     T G   +  L++  G
Sbjct  154  QQPPASTPGDQRNSALIALQG  174


>gi|68840132|sp|Q96SN8|CK5P2_HUMAN  CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding 
protein C48)
Length=1893

 Score = 31.2 bits (69),  Expect = 3.1
 Identities = 30/115 (26%), Positives = 56/115 (48%), Gaps = 11/115 (9%)

Query  1199  DSVTSTFSKLREQLGPV-TQEFWDNLEKETE-GLRQEMSKDLEE---VKAKVQPYLDDFQ  1253
             + +++ F+K RE L    TQEF  + + ET    ++ +S  L      K+     L    
Sbjct  342   EKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSI  401

Query  1254  KKWQEEMELYRQKVEPLRAELQEGARQK------LHELQEKLSPLGEEMRDRARA  1302
             KK  +E+   +Q+ E L  +L+E  R+K      + +L+ ++  L  E+ +R +A
Sbjct  402   KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKA  456


>gi|54035738|sp|Q9Y2D8|ADIP_HUMAN  Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL 
domain-interacting protein) (SSX2-interacting protein)
Length=614

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 7/92 (7%)

Query  1191  NLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETE------GLRQEMSKDLEEVKAK  1244
             NLKL  + D + S +SKL+EQL    +E     E++ +       L Q +  + +EV+ K
Sbjct  124   NLKLGSDMDHLQSCYSKLKEQLETSRREMIGLQERDRQLQCKNRNLHQLLKNEKDEVQ-K  182

Query  1245  VQPYLDDFQKKWQEEMELYRQKVEPLRAELQE  1276
             +Q  +     ++  +M+   ++   L+  L +
Sbjct  183   LQNIIASRATQYNHDMKRKEREYNKLKERLHQ  214


>gi|42558969|sp|Q13136|LIPA1_HUMAN  Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f 
polypeptide-interacting protein alpha-1) (PTPRF-interacting 
protein alpha-1) (LAR-interacting protein 1) (LIP.1)
Length=1202

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 23/97 (23%), Positives = 48/97 (49%), Gaps = 2/97 (2%)

Query  1221  DNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEG-AR  1279
             D++ ++TE   +++ + LE  + K+Q  L   +   + E EL ++     +AE + G   
Sbjct  354   DSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIE  413

Query  1280  QKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSD  1316
             ++L +++ +L    +E++ RAR        H    SD
Sbjct  414   ERLRQMEAQLEEKNQELQ-RARQREKMNEEHNKRLSD  449


>gi|25008939|sp|O75626|PRDM1_HUMAN  PR-domain zinc finger protein 1 (Beta-interferon gene positive-regulatory 
domain I binding factor) (BLIMP-1) (Positive regulatory 
domain I-binding factor 1) (PRDI-binding factor 1) 
(PRDI-BF1)
Length=789

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 5/57 (8%)

Query  1225  KETEGLRQEMSKDLEEVKAKVQPY-----LDDFQKKWQEEMELYRQKVEPLRAELQE  1276
             KE   L    SK  +  ++ + P      LDDF+++   EM  Y + V P+RA L E
Sbjct  215   KEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPE  271


>gi|62512161|sp|O95239|KIF4A_HUMAN  Chromosome-associated kinesin KIF4A (Chromokinesin)
Length=1232

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 27/116 (23%), Positives = 56/116 (48%), Gaps = 23/116 (19%)

Query  1186  LGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKV  1245
             L K L LK     +++    ++   QL P+  ++ DN+ KE E     + K+ EE+    
Sbjct  529   LNKALALK-----EALARKMTQNDSQLQPIQYQYQDNI-KELELEVINLQKEKEELV---  579

Query  1246  QPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR  1301
                           +EL   K +  +A+L E  R++L EL+ +++ L +++ ++++
Sbjct  580   --------------LELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSK  621


>gi|32469788|sp|Q9NYA3|GOGA6_HUMAN  Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like 
protein)
Length=693

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 5/84 (5%)

Query  1225  KETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHE  1284
             +E E    E+   + E  +   P +    ++ Q+E +  RQ+VE L     EG  Q   E
Sbjct  269   QELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGL-----EGKLQSQVE  323

Query  1285  LQEKLSPLGEEMRDRARAHVDALR  1308
               + LS L +E + R +   + LR
Sbjct  324   NNQALSLLSKEQKQRLQEQEEMLR  347


>gi|17373489|sp|Q13111|CAF1A_HUMAN  Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin 
assembly factor I p150 subunit) (CAF-I 150 kDa subunit) 
(CAF-Ip150)
Length=938

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 23/75 (30%), Positives = 38/75 (50%), Gaps = 4/75 (5%)

Query  1225  KETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHE  1284
             +E E L++E  +  EE K K +   +  +K+ +E+    R+K E  +AE Q    ++  E
Sbjct  337   EEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREK----REKDEKEKAEKQRLKEERRKE  392

Query  1285  LQEKLSPLGEEMRDR  1299
              QE L    EE R +
Sbjct  393   RQEALEAKLEEKRKK  407


>gi|400793|sp|Q00722|PLCB2_HUMAN  1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 
2 (Phosphoinositide phospholipase C) (Phospholipase C-beta-2) 
(PLC-beta-2)
Length=1181

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 17/71 (23%), Positives = 41/71 (57%), Gaps = 9/71 (12%)

Query  1210  EQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEE-MELYRQKVE  1268
             +++  V ++  +NLE+  E L ++ +  LE+++        + +K++Q+E +  Y  +++
Sbjct  1077  QEVVQVIKQMTENLERHQEKLEEKQAACLEQIR--------EMEKQFQKEALAEYEARMK  1128

Query  1269  PLRAELQEGAR  1279
              L AE++E  R
Sbjct  1129  GLEAEVKESVR  1139


>gi|55976299|sp|Q14134|TRI29_HUMAN  Tripartite motif protein 29 (Ataxia-telangiectasia group D-associated 
protein)
Length=588

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 20/85 (23%), Positives = 44/85 (51%), Gaps = 6/85 (7%)

Query  1224  EKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLH  1283
             EKETE     +S   E+++ K+   ++D  +KWQ+E +  +      +A L++  R  + 
Sbjct  266   EKETE-----LSLQKEQLQLKIIE-IEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVR  319

Query  1284  ELQEKLSPLGEEMRDRARAHVDALR  1308
             +L+++   +   +  R +  VD ++
Sbjct  320   DLEKQKEEVRAALEQREQDAVDQVK  344


>gi|14194715|sp|Q92817|EVPL_HUMAN  Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) 
(210 kDa cornified envelope precursor protein)
Length=2033

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 27/115 (23%), Positives = 48/115 (41%), Gaps = 14/115 (12%)

Query  1161  DLATV---YVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQ  1217
             D AT+   Y D+LK       + + G +LG      L  +    T   S L EQ   + Q
Sbjct  203   DAATIRSQYRDLLK------AASWRGQSLGS-----LYTHLQGCTRQLSALAEQQRRILQ  251

Query  1218  EFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRA  1272
             + W +L  +  G+R+E     +      +  ++  +   +  +EL    V P++A
Sbjct  252   QDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQA  306


>gi|22653665|sp|Q9NRL2|BAZ1A_HUMAN  Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing 
chromatin assembly and remodeling factor 1) (hACF1) 
(ATP-dependent chromatin remodelling protein) (Williams syndrome 
transcription factor-related chromatin remodeling factor 
180) (WCRF180) (hWALp1) (CHRAC subunit ACF1)
Length=1556

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 23/90 (25%), Positives = 46/90 (51%), Gaps = 3/90 (3%)

Query  1230  LRQEMSKDLEEVKAKVQPYLDD---FQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQ  1286
             L+QE  K L   KAK++    D    +KK +E+ E  R++++ +  E +   +++   L+
Sbjct  312   LKQEEMKSLAFEKAKLKREKADALEAKKKEKEDKEKKREELKKIVEEERLKKKEEKERLK  371

Query  1287  EKLSPLGEEMRDRARAHVDALRTHLAPYSD  1316
              +     E++R+  R +V+ L+    P  D
Sbjct  372   VEREKEREKLREEKRKYVEYLKQWSKPRED  401


>gi|29839588|sp|Q8WXH0|SYNE2_HUMAN  Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) 
(Synaptic nuclear envelope protein 2) (Nucleus and actin 
connecting element protein) (NUANCE protein)
Length=6885

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 18/65 (27%), Positives = 35/65 (53%), Gaps = 8/65 (12%)

Query  1228  EGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQE  1287
             E + Q+ SK++E+ +        + QKK  +E++L+  K+  L +E+Q+   Q   + QE
Sbjct  3703  EKMLQQKSKNIEKAQ--------EIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQE  3754

Query  1288  KLSPL  1292
              +  L
Sbjct  3755  WMDNL  3759


>gi|28201884|sp|P78424|PO6F2_HUMAN  POU domain, class 6, transcription factor 2 (Retina-derived POU-domain 
factor 1) (RPF-1)
Length=684

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 7/58 (12%)

Query  885  SPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQPALMHSES  942
            +P+Q+ + P     P  PP A QQPP   TS LQQA      P   +HQ  +  H+++
Sbjct  204  APSQSQQQPLQPTPPQQPPPASQQPP-APTSQLQQA------PQPQQHQPHSHSHNQN  254


>gi|73620945|sp|O94833|BPAEA_HUMAN  Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) 
(Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque 
protein) (Dystonia musculorum protein) (Dystonin)
Length=5171

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 37/162 (22%), Positives = 72/162 (44%), Gaps = 39/162 (24%)

Query  1167  VDVLKDSGRDYV---SQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLG---PVTQEFW  1220
             +D L  SG   +   S+ E  ++ K+L+ K+L N+D++    S+   QL     +  +FW
Sbjct  3473  IDDLVKSGHKIMTACSEEEKQSMKKKLD-KVLKNYDTICQINSERYLQLERAQSLVNQFW  3531

Query  1221  DN----------------------LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQE  1258
             +                       LE ET   +QE  + L E+ A+ +P++D   K   +
Sbjct  3532  ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ  3591

Query  1259  EMEL-------YRQK---VEPLRAELQEGARQKLHELQEKLS  1290
              +EL        ++K    + L ++++E  +++   L E +S
Sbjct  3592  LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAIS  3633


>gi|12643326|sp|Q9ULV3|CIZ1_HUMAN  Cip1-interacting zinc finger protein (Nuclear protein NP94)
Length=898

 Score = 30.8 bits (68),  Expect = 4.0
 Identities = 17/49 (34%), Positives = 22/49 (44%), Gaps = 1/49 (2%)

Query  894  PLDQF-PTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQPALMHSE  941
            PL Q  P   P AH QPP      LQ+ + + T P      QP++   E
Sbjct  399  PLKQVQPQVQPQAHSQPPRQVQLQLQKQVQTQTYPQVHTQAQPSVQPQE  447


>gi|12643319|sp|O75665|OFD1_HUMAN  Oral-facial-digital syndrome 1 protein (Protein 71-7A)
Length=1012

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 17/88 (19%), Positives = 48/88 (54%), Gaps = 1/88 (1%)

Query  1224  EKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLH  1283
             +KE E +R++  K+  + + + Q  L +  ++ + E+E   Q+ + +   L+   +++L 
Sbjct  876   QKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKEL-  934

Query  1284  ELQEKLSPLGEEMRDRARAHVDALRTHL  1311
             E++ +L    +E++D++    + L  ++
Sbjct  935   EMENELEMSNQEIKDKSAHSENPLEKYM  962


>gi|74745646|sp|Q5T9A4|ATD3B_HUMAN  ATPase family AAA domain-containing protein 3B
Length=648

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 49/215 (22%), Positives = 78/215 (36%), Gaps = 28/215 (13%)

Query  1103  SSLMGSQQFQDGENEGPPRPFRMKaavltlavlfltGSQARHFWQQDEPPQSPWDRVKDL  1162
             S L G  +   GE  GPP P                G         D P  +P D+  + 
Sbjct  2     SWLFGVNKGPKGEGAGPPPPLPPAQPGAEGGGDRGLG---------DRP--APKDKWSNF  50

Query  1163  ATVYVDVLKDSGRDYVSQFEGSALGKQ-LNLKLLDNWDSVTSTFSKLREQLGPVTQEFWD  1221
                 ++    + R+     E S   K+ LNL  +          SKL+E    V Q   +
Sbjct  51    DPTGLERAAKAARE----LEHSRYAKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSE  106

Query  1222  NLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK  1281
              +  + E  R+ +S++  + +A+ Q Y D   ++  E+    +Q +       QE + QK
Sbjct  107   QIRAQAEERRKTLSEETRQHQARAQ-YQDKLARQRYEDQLKQQQLLNEENLRKQEESVQK  165

Query  1282  LH-----------ELQEKLSPLGEEMRDRARAHVD  1305
                          EL+ K   L  E   RARA  +
Sbjct  166   QEAMRRATVEREMELRHKNEMLRVETEARARAKAE  200


>gi|6166599|sp|P35579|MYH9_HUMAN  Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin 
heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin 
heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A)
Length=1960

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 7/90 (7%)

Query  1207  KLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQK  1266
             +L EQL   T+    NLEK  + L  E  +   EVK  +Q   D   K+ + E +L    
Sbjct  1200  ELAEQLEQ-TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL----  1254

Query  1267  VEPLRAELQEGARQKLHELQEKLSPLGEEM  1296
              + L+ +  EG R +  EL +K++ L  E+
Sbjct  1255  -QELQVKFNEGERVRT-ELADKVTKLQVEL  1282


>gi|83288393|sp|Q92954|PRG4_HUMAN  Proteoglycan-4 precursor (Lubricin) (Megakaryocyte stimulating 
factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 
C-terminal part]
Length=1404

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 17/66 (25%), Positives = 31/66 (46%), Gaps = 0/66 (0%)

Query  899  PTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQPALMHSESMEEDCSCEGAKDGFQD  958
            PT PPS+ + PP    S   ++    +P    + +   ++ SE + E+ S    ++    
Sbjct  110  PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS  169

Query  959  SKSSST  964
            S SSS+
Sbjct  170  SSSSSS  175


>gi|20454925|sp|Q96RT7|GCP6_HUMAN  Gamma-tubulin complex component 6 (GCP-6)
Length=1819

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 20/66 (30%), Positives = 35/66 (53%), Gaps = 1/66 (1%)

Query  1225  KETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHE  1284
             ++ + L+++  KD E  +A  Q  LDD    +  E+    ++++ L  EL+  ARQ L +
Sbjct  704   EQFQRLKEQFVKDQERRQAARQEELDD-DFSYARELRDRERRLKSLEEELERKARQALVD  762

Query  1285  LQEKLS  1290
                KLS
Sbjct  763   HYSKLS  768


>gi|1345731|sp|P49454|CENPF_HUMAN  CENP-F kinetochore protein (Centromere protein F) (Mitosin) (AH 
antigen)
Length=3210

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 12/108 (11%)

Query  1195  LDNWDSVTSTFSKLREQLGPVTQEFWDNLEK----------ETEGLRQEMSKDLEEVKAK  1244
             L++   + S   K  E+L  +  E  +NL K          ET     ++ +D    +  
Sbjct  839   LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV  898

Query  1245  VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPL  1292
             V   L   + K ++E++L   KVE  +AE+QE  ++  H L++ L  L
Sbjct  899   VAETLSALENK-EKELQLLNDKVETEQAEIQE-LKKSNHLLEDSLKEL  944


>gi|1709078|sp|P50221|MEOX1_HUMAN  Homeobox protein MOX-1 (Mesenchyme homeobox 1)
Length=254

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 28/113 (24%), Positives = 44/113 (38%), Gaps = 13/113 (11%)

Query  895  LDQFPTFPPSAHQQPPHYTTSA-----LQQALLSPTPPDYTRH------QQPALMHSESM  943
            L  +P  P S HQ+P    T+         + L+ TP    +       Q PA   S + 
Sbjct  35   LPHYPPTPFSFHQKPDFLATATAAYPDFSASCLAATPHSLPQEEHIFTEQHPAFPQSPNW  94

Query  944  EEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQE  996
                S   A+       +  +   G     L+ +TGGPGD   +LG+ ++  E
Sbjct  95   HFPVS--DARRRPNSGPAGGSKEMGTSSLGLVDTTGGPGDDYGVLGSTANETE  145


>gi|45593726|sp|Q99986|VRK1_HUMAN  Serine/threonine-protein kinase VRK1 (Vaccinia-related kinase 
1)
Length=396

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 26/115 (22%), Positives = 47/115 (40%), Gaps = 9/115 (7%)

Query  78   RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL--NIKIADFGFSNLFTPG  135
            R + K   +   +I+  + + H    VH D+KA NLLL+      + + D+G +  + P 
Sbjct  148  RFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPE  207

Query  136  QLLKTWCGSPPYAAPELFEGKEYD-------GPKVDIWSLGVVLYVLVCGALPFD  183
             + K +   P        E    D         + D+  LG  +   + G LP++
Sbjct  208  GVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWE  262


>gi|51701377|sp|O15083|ERC2_HUMAN  ERC protein 2
Length=957

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 27/128 (21%), Positives = 57/128 (44%), Gaps = 6/128 (4%)

Query  1172  DSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLR  1231
             D  +  +S+ E   L  Q  L+ L N +S      ++ ++     ++    L+ E + LR
Sbjct  437   DQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALR  496

Query  1232  QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSP  1291
               + +    +  K +   D  ++K     E+   K      ++ E   +K++ LQ+K+  
Sbjct  497   LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMK------DMLEVKERKINVLQKKIEN  550

Query  1292  LGEEMRDR  1299
             L E++RD+
Sbjct  551   LQEQLRDK  558


>gi|13432177|sp|P35749|MYH11_HUMAN  Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC)
Length=1972

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 6/84 (7%)

Query  1221  DNLEKETEGLRQEMSKDLEEVKAKVQPYLDD---FQKKWQEEMELYRQKVEPLRAELQEG  1277
             D L+K T+  +Q+   +L+E++ K     ++    Q++ Q E ELY +  E +R  L   
Sbjct  859   DELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-AEEMRVRL-AA  915

Query  1278  ARQKLHELQEKLSPLGEEMRDRAR  1301
              +Q+L E+  ++    EE  DR +
Sbjct  916   KKQELEEILHEMEARLEEEEDRGQ  939


>gi|33112673|sp|Q9Y496|KIF3A_HUMAN  Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin 
motor 3A)
Length=702

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 15/43 (34%), Positives = 29/43 (67%), Gaps = 1/43 (2%)

Query  1259  EMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR  1301
             E+E  R++ E LR EL+E  +++L +++EK + L EE + + +
Sbjct  506   ELEERRKRAEQLRRELEEKEQERL-DIEEKYTSLQEEAQGKTK  547


>gi|77416379|sp|Q9UPN4|AZI1_HUMAN  5-azacytidine-induced protein 1 (Pre-acrosome localization protein 
1) (Centrosomal protein of 131 kDa) (Cep131 protein)
Length=1083

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 9/82 (10%)

Query  1217  QEFWDNLEKETEGL--------RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVE  1268
             +E  + LE+E E L        RQ   + LE+ +  +Q        +  EE E   Q+  
Sbjct  753   EELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAA  812

Query  1269  PLRAELQEGARQKLHELQEKLS  1290
               RAEL+E  RQ+L E    L+
Sbjct  813   RQRAELEE-LRQQLEESSSALT  833


>gi|57015374|sp|P49750|YLPM1_HUMAN  YLP motif containing protein 1 (Nuclear protein ZAP3) (ZAP113)
Length=1951

 Score = 30.4 bits (67),  Expect = 5.3
 Identities = 43/206 (20%), Positives = 82/206 (39%), Gaps = 34/206 (16%)

Query  1114  GENEGPPRPFRMKaavltlavlfltGSQARHFWQQDEPPQSPWDRVKDL-----------  1162
             G + GP RP                G +  + + +DEPP++PW+  ++            
Sbjct  968   GRDRGPFRP------------EPGDGGEKMYPYHRDEPPRAPWNHGEERGHEEFPLDGRN  1015

Query  1163  ATVYVDVLKDSGRD-YVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWD  1221
             A +  + L D  R+ Y  + E       L L   ++  S   + S   ++ GP    +WD
Sbjct  1016  APMERERLDDWDRERYWRECERDYQDDTLELYNREDRFSAPPSRSHDGDRRGP----WWD  1071

Query  1222  NLEKE---TEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMEL-YRQKVEPLRAELQEG  1277
             + E++    E   +EM +D++    ++   +D + +    E +  Y + ++   ++ +E 
Sbjct  1072  DWERDQDMDEDYNREMERDMDRDVDRISRPMDMYDRSLDNEWDRDYGRPLDEQESQFRER  1131

Query  1278  ARQKLHELQ--EKLSPLGEEMRDRAR  1301
                 L  L     L PL     DR R
Sbjct  1132  DIPSLPPLPPLPPLPPLDRYRDDRWR  1157


>gi|68053233|sp|Q9H7L9|SDS3_HUMAN  Sin3 histone deacetylase corepressor complex component SDS3
Length=328

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 18/88 (20%), Positives = 41/88 (46%), Gaps = 0/88 (0%)

Query  1214  PVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAE  1273
             P   E  ++ E +    R   S +  E  ++      D +   + + ++Y+ K+  L+ +
Sbjct  24    PEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQ  83

Query  1274  LQEGARQKLHELQEKLSPLGEEMRDRAR  1301
             LQ+     L E Q+++  L ++ ++R R
Sbjct  84    LQQLQEGTLQEYQKRMKKLDQQYKERIR  111


>gi|13124568|sp|Q9UPE1|STK23_HUMAN  Serine/threonine-protein kinase 23 (Muscle-specific serine kinase 
1) (MSSK-1)
Length=533

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 10/81 (12%)

Query  110  AENLLLDA-------NLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK  162
            A NLL++         + IKIAD G  N     +       +  Y A E+  G EY GP 
Sbjct  353  ASNLLVNPLEPQNADKIKIKIADLG--NACWVHKHFTEDIQTRQYRAVEVLIGAEY-GPP  409

Query  163  VDIWSLGVVLYVLVCGALPFD  183
             DIWS   + + L  G   F+
Sbjct  410  ADIWSTACMAFELATGDYLFE  430


>gi|18202959|sp|Q9HCU9|BRMS1_HUMAN  Breast cancer metastasis-suppressor 1
Length=246

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 21/78 (26%), Positives = 40/78 (51%), Gaps = 2/78 (2%)

Query  1224  EKETEGLRQEMS-KDLEEVKAKVQPYLDDFQKKWQEEME-LYRQKVEPLRAELQEGARQK  1281
             + E+E    EM  +D E  +++    + D +K++ E  E L+R+++  LR  L+E   ++
Sbjct  38    QTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAER  97

Query  1282  LHELQEKLSPLGEEMRDR  1299
               E  E L  L   ++ R
Sbjct  98    APEYTEPLGGLQRSLKIR  115


>gi|134798|sp|P11277|SPTB1_HUMAN  Spectrin beta chain, erythrocyte (Beta-I spectrin)
Length=2137

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 37/147 (25%), Positives = 62/147 (42%), Gaps = 23/147 (15%)

Query  1156  WDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNL----KLLDNWD-----SVTSTFS  1206
             WD++KDLA      L+D+   +  QF+G A   +  L    +LL   D       T    
Sbjct  725   WDQLKDLAAFCKKNLQDAENFF--QFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALG  782

Query  1207  KLREQLGPVTQE---FWDNLEKETEGLRQEMS---------KDLEEVKAKVQPYLDDFQK  1254
             K  +      +E     ++LE++ +G  +E           + L E+  +V    D  Q+
Sbjct  783   KKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQ  842

Query  1255  KWQEEMELYRQKVEPLRAELQEGARQK  1281
             + QE ++LY    E    EL  G ++K
Sbjct  843   RLQEALDLYTVFGETDACELWMGEKEK  869


>gi|25452905|sp|Q9H501|CT006_HUMAN  Hypothetical protein C20orf6
Length=851

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 5/75 (6%)

Query  1221  DNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKK----WQEEMELYRQKVEPLRAELQE  1276
             D +  E +G  ++  KD EE  AK +  L   Q+K     + +ME+  + V  L+   +E
Sbjct  558   DGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEE  617

Query  1277  GARQKLHELQEKLSP  1291
               + KL E ++KL+P
Sbjct  618   MVKNKL-EGKDKLTP  631


>gi|74749877|sp|Q7L014|DDX46_HUMAN  Probable ATP-dependent RNA helicase DDX46 (DEAD box protein 46) 
(PRP5 homolog)
Length=1032

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 19/67 (28%), Positives = 39/67 (58%), Gaps = 5/67 (7%)

Query  1232  QEMSKDLEEVKAKVQPYLDDF-QKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS  1290
             +E  KD ++ + + +    +F Q K +EEM   +++VE  R E ++ A + + EL++++ 
Sbjct  131   KEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEI-  189

Query  1291  PLGEEMR  1297
                EEM+
Sbjct  190   ---EEMK  193


>gi|14916998|sp|P00390|GSHR_HUMAN  Glutathione reductase, mitochondrial precursor (GR) (GRase)
Length=522

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 10/66 (15%)

Query  1044  GYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGK---ALSSARMSDAVL  1100
             G P+ P  HE   P A     ++  + D + QL+ LPG S++ G    A+  A +  A+ 
Sbjct  202   GMPSTP--HESQIPGA-----SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALG  254

Query  1101  SQSSLM  1106
             S++SLM
Sbjct  255   SKTSLM  260


>gi|1169868|sp|P32456|GBP2_HUMAN  Interferon-induced guanylate-binding protein 2 (GTP-binding protein 
2) (Guanine nucleotide-binding protein 2) (HuGBP-2)
Length=591

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 22/81 (27%), Positives = 43/81 (53%), Gaps = 5/81 (6%)

Query  1226  ETEGLRQEMS----KDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK  1281
             E E ++ E +    K LEE++ K +  ++  +K +QE ++   +K+E  RA+L     + 
Sbjct  488   EVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKT  547

Query  1282  LH-ELQEKLSPLGEEMRDRAR  1301
             L  +LQE+   L E   + ++
Sbjct  548   LALKLQEQERLLKEGFENESK  568


>gi|731165|sp|Q02040|XE7_HUMAN  B-lymphocyte antigen precursor (B-lymphocyte surface antigen) 
(721P) (Protein XE7)
Length=695

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 21/71 (29%), Positives = 38/71 (53%), Gaps = 2/71 (2%)

Query  1225  KETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHE  1284
             +E E  R+E  +   E +A+ +   ++ ++K  EE+E  R++ E LR   Q+   ++L  
Sbjct  279   QELEQQREEQKR--REKEAEERQRAEERKQKELEELERERKREEKLRKREQKQRDRELRR  336

Query  1285  LQEKLSPLGEE  1295
              Q+KL  L  E
Sbjct  337   NQKKLEKLQAE  347


>gi|2498204|sp|Q05682|CALD1_HUMAN  Caldesmon (CDM)
Length=793

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 26/98 (26%), Positives = 47/98 (47%), Gaps = 6/98 (6%)

Query  1187  GKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQ  1246
             GK+L        ++ +  F KL+++      E      +E +  R+E  K LEE + + +
Sbjct  533   GKRLEELRRRRGETESEEFEKLKQKQQEAALEL-----EELKKKREERRKVLEEEEQRRK  587

Query  1247  PYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHE  1284
                 D + + +EE    ++++E  RAE  E  RQK+ E
Sbjct  588   QEEADRKLREEEEKRRLKEEIERRRAEAAE-KRQKMPE  624


>gi|88909601|sp|Q5BJE1|CR034_HUMAN  Protein C18orf34
Length=867

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 24/108 (22%), Positives = 48/108 (44%), Gaps = 14/108 (12%)

Query  1194  LLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYL----  1249
             ++D  D +     K++++L    ++  D L  ETE  R  + KDLE  K+K   +     
Sbjct  611   IIDQKDLIRRKVGKVKKKLRKKGKKTLDALI-ETESKRSAIFKDLEATKSKTMIFYAKIN  669

Query  1250  ---------DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEK  1288
                      ++ +K + + +E+ + K   +R + +       H +QEK
Sbjct  670   ELNEELKAKEEEKKSFDQTLEILKNKFITMRFKREHAQTVFDHYMQEK  717


>gi|51338794|sp|P78559|MAP1A_HUMAN  Microtubule-associated protein 1A (MAP 1A) (Proliferation-related 
protein p80) [Contains: MAP1 light chain LC2]
Length=2805

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 22/91 (24%), Positives = 47/91 (51%), Gaps = 3/91 (3%)

Query  1223  LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKL  1282
             +E+  +  R E++K+L + + K +   +   +K  +   +  +  E L+AE ++  + K+
Sbjct  341   VEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIKDKV  400

Query  1283  --HELQEKLSPLGEEMRDRARAHVDALRTHL  1311
                 L+EK+S L EE +D+ +  +   R  L
Sbjct  401   GKKHLKEKISKL-EEKKDKEKKEIKKERKEL  430


>gi|14195666|sp|O60841|IF2P_HUMAN  Eukaryotic translation initiation factor 5B (eIF-5B) (Translation 
initiation factor IF-2)
Length=1220

 Score = 30.0 bits (66),  Expect = 6.9
 Identities = 29/95 (30%), Positives = 47/95 (49%), Gaps = 12/95 (12%)

Query  1224  EKETE---GLRQEMSKDLEEVKAKV------QPYLDDFQKKWQEEMELYRQKVEPLRAEL  1274
             EKE E   G  +   K ++E  AK+      Q   ++ + K  EE+E  R++ E L  E 
Sbjct  327   EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEK  386

Query  1275  QEGARQKLHELQEKLSPLGE---EMRDRARAHVDA  1306
             +E  +QK  E +E+L   G+   + +  ARA  +A
Sbjct  387   RERKKQKEKERKERLKKEGKLLTKSQREARARAEA  421


>gi|45645200|sp|Q92599|SEPT8_HUMAN  Septin-8
Length=483

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 31/113 (27%), Positives = 57/113 (50%), Gaps = 18/113 (15%)

Query  1199  DSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQE  1258
             D  +  FS L+E      +EF   L+++ E +RQ     ++E + +++          ++
Sbjct  314   DGDSQPFS-LQETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELK----------EK  362

Query  1259  EMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR--DRARAHVDALRT  1309
             E EL+ +K E L+   QE  R    +++EK   L EE    +R +A V+AL++
Sbjct  363   ERELH-EKFEHLKRVHQEEKR----KVEEKRRELEEETNAFNRRKAAVEALQS  410


>gi|38372394|sp|Q9NUV9|GIMA4_HUMAN  GTPase, IMAP family member 4 (Immunity-associated protein 4) 
(Immunity-associated nucleotide 1 protein) (hIAN1)
Length=329

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 12/40 (30%), Positives = 27/40 (67%), Gaps = 0/40 (0%)

Query  1250  DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKL  1289
             ++ QK+ Q   EL+R ++E  +A ++E   +K+ +L++K+
Sbjct  231   EEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKV  270


>gi|2833266|sp|Q15696|U2AFM_HUMAN  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit 
related-protein 2 (U2(RNU2) small nuclear RNA auxillary 
factor 1-like 2)
Length=482

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 33/119 (27%), Positives = 55/119 (46%), Gaps = 9/119 (7%)

Query  1170  LKDSGRDYVSQFEGSALGKQL--NLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKET  1227
             L+DSG     + E + + +Q     KLL+           LREQ     +EF    EKE 
Sbjct  37    LRDSGLSQKEEEEDTFIEEQQLEEEKLLERERQRLHEEWLLREQ--KAQEEFRIKKEKEE  94

Query  1228  EGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQ  1286
                +++     EE + K++   ++ Q+K +EE E  RQ+ +     LQ+   Q  +EL+
Sbjct  95    AAKKRQ-----EEQERKLKEQWEEQQRKEREEEEQKRQEKKEKEEALQKMLDQAENELE  148


>gi|20139283|sp|Q9UL16|CCD19_HUMAN  Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium-specific 
protein 1)
Length=386

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 26/108 (24%), Positives = 48/108 (44%), Gaps = 20/108 (18%)

Query  1193  KLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEV-----------  1241
             K++   + V +   KL + L  V +E   NL +    LR E  ++L+++           
Sbjct  9     KIMKQKEMVWNNNKKLSD-LEEVAKERAQNLLQRANKLRMEQEEELKDMSKIILNAKCHA  67

Query  1242  --------KAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK  1281
                     K ++Q  LD  +K+  + ME+ RQK    + EL+   R++
Sbjct  68    IRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREE  115


 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 24/89 (26%), Positives = 49/89 (55%), Gaps = 6/89 (6%)

Query  1207  KLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQK  1266
             K RE+     ++  + +EK  E  R  +++  E+ K ++  Y++  Q++  ++ME  +Q+
Sbjct  111   KRREERIRGRRQIVEQMEKNQEE-RSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQ  169

Query  1267  VEPLRAELQ----EGARQKLHEL-QEKLS  1290
                ++AE++    E  +QK   L QEKL+
Sbjct  170   KLKMQAEIKRINDENQKQKAELLAQEKLA  198


>gi|8134347|sp|O43683|BUB1_HUMAN  Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) 
(BUB1A)
Length=1085

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 20/94 (21%), Positives = 40/94 (42%), Gaps = 15/94 (15%)

Query  99    HCRNIVHRDLKAENLLL-----------DANLNIKIADFGFS---NLFTPGQLLKTWCGS  144
             H   I+H D+K +N +L           D +  + + D G S    LF  G +    C +
Sbjct  909   HDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCET  968

Query  145   PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG  178
               +   E+   K ++  ++D + +   +Y ++ G
Sbjct  969   SGFQCVEMLSNKPWN-YQIDYFGVAATVYCMLFG  1001


>gi|55583953|sp|Q8N3L3|TXLNB_HUMAN  Beta-taxilin (Muscle-derived protein 77) (hMDP77)
Length=684

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 25/120 (20%), Positives = 52/120 (43%), Gaps = 2/120 (1%)

Query  1157  DRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVT  1216
             ++ K++ + +   L D       Q E +    Q N +L +   S+   +    E L  + 
Sbjct  241   EKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENTELAEKLKSIIDQYELREEHLDKIF  300

Query  1217  Q--EFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAEL  1274
             +  E    L        QEM K+ EE   + + YL +   +W+ + ++ +++   L+A+L
Sbjct  301   KHRELQQKLVDAKLEQAQEMMKEAEERHKREKEYLLNQAAEWKLQAKVLKEQETVLQAQL  360


>gi|51827892|sp|Q8IUD2|RB6I2_HUMAN  RAB6-interacting protein 2 (ERC protein 1)
Length=1116

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 50/275 (18%), Positives = 113/275 (41%), Gaps = 23/275 (8%)

Query  1039  DHNGLGYPARPSVHEHHRPRALQRHHTIQNS---DDAYVQLDNLPGMSLVAGKALSSA-R  1094
             DH      A   +H HH    L++    +NS   ++ + + +N P  +    KAL +   
Sbjct  329   DHERTRRLAEAEMHVHHLESLLEQKEK-ENSMLREEMHRRFENAPDSAKT--KALQTVIE  385

Query  1095  MSDAVLSQSSLMGSQQFQD--------GENEGPPRPFRMKaavltlavlfltGSQARHFW  1146
             M D+ +S S   G +  ++        G      R   MK   +  +      ++     
Sbjct  386   MKDSKIS-SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK  444

Query  1147  QQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFS  1206
             ++    ++ W+ +K  A      +    ++ +S+ +   L  Q  L+ L N  S +    
Sbjct  445   EELSSKEAQWEELKKKAAGLQAEIGQVKQE-LSRKDTELLALQTKLETLTNQFSDSKQHI  503

Query  1207  KLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQK  1266
             ++ ++     ++    L+ E + LR  + +    +  K +   D  ++K  +  E++  K
Sbjct  504   EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK  563

Query  1267  VEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR  1301
                   ++ +   +K++ LQ+K+  L E++RD+ +
Sbjct  564   ------DMLDVKERKVNVLQKKIENLQEQLRDKEK  592


>gi|33302627|sp|Q15643|TRIPB_HUMAN  Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated 
microtubule-binding protein 210) (GMAP-210) (Trip230) 
(Clonal evolution related gene on chromosome 14)
Length=1979

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 21/89 (23%), Positives = 43/89 (48%), Gaps = 11/89 (12%)

Query  1211  QLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPL  1270
             +L  + +E   N  +E +  + EMS     ++   Q  L +  ++ +EE+  Y +++E L
Sbjct  213   KLQNIIKELKQNRSQEIDDHQHEMSV----LQNAHQQKLTEISRRHREELSDYEERIEEL  268

Query  1271  RAELQEGAR-------QKLHELQEKLSPL  1292
                LQ+G          K++E+Q+ +  L
Sbjct  269   ENLLQQGGSGVIETDLSKIYEMQKTIQVL  297


>gi|1730009|sp|P12270|TPR_HUMAN  Nucleoprotein TPR
Length=2349

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 23/98 (23%), Positives = 49/98 (50%), Gaps = 2/98 (2%)

Query  1210  EQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEP  1269
             EQ   +     ++L KE + + +E+ K++E    +   +    +KK  E +E  +Q+++ 
Sbjct  963   EQYQAMVTSLEESLNKEKQ-VTEEVRKNIEVRLKESAEFQTQLEKKLME-VEKEKQELQD  1020

Query  1270  LRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDAL  1307
              +    E   Q+L EL++ LS +  E+++  +    AL
Sbjct  1021  DKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL  1058


>gi|3023440|sp|Q92793|CBP_HUMAN  CREB-binding protein
Length=2442

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 39/156 (25%), Positives = 59/156 (37%), Gaps = 16/156 (10%)

Query  890   LKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQ-----QPALMHSESME  944
             L  PP+ Q P      H  PP  +T+A   +L   TPP  T  Q     QP+   S S +
Sbjct  843   LPCPPVTQSPL-----HPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQ  897

Query  945   EDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQE---LGIHP  1001
                   G+      ++S+ T+ +    + +      P  P S+    S  Q+   +   P
Sbjct  898   TPTPTPGSVPSATQTQSTPTV-QAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQP  956

Query  1002  YGH--QPTAAFSKNKVPSREPVIGNCMDRSSPGQAV  1035
              G      AA   N+VP+   V     +   PG  V
Sbjct  957   PGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDV  992


>gi|52000729|sp|Q8WWM7|ATX2L_HUMAN  Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related 
protein)
Length=1075

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 15/53 (28%), Positives = 25/53 (47%), Gaps = 3/53 (5%)

Query  886  PTQALKVPPLDQFPT---FPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQP  935
            P Q   + P+  +P+   F P     P   T+ +  QA++S + P Y   +QP
Sbjct  796  PGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQP  848


>gi|23503097|sp|P57071|PRD15_HUMAN  PR-domain zinc finger protein 15 (Zinc finger protein 298)
Length=1507

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 15/56 (26%), Positives = 27/56 (48%), Gaps = 4/56 (7%)

Query  463   NGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEP  518
             +G   L  R +D    +Q+H Q     P+  +  + +T  V ++TP+  + SD  P
Sbjct  1415  SGSAMLHNRQND----VQIHPQPEASNPQSVAHFINLTTLVNSITPLGSQLSDQHP  1466


>gi|6226826|sp|O75330|HMMR_HUMAN  Hyaluronan mediated motility receptor (Intracellular hyaluronic 
acid binding protein) (Receptor for hyaluronan-mediated motility) 
(CD168 antigen)
Length=724

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 26/112 (23%), Positives = 48/112 (42%), Gaps = 12/112 (10%)

Query  1199  DSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQP---------YL  1249
             DS+     +L   L      F + + KE     +E+ + L+E+    Q           L
Sbjct  343   DSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQL  402

Query  1250  DDFQKKWQEEMELYRQKVEPLRAELQEGA---RQKLHELQEKLSPLGEEMRD  1298
             ++  K   EE++L  +K++   AEL++ +    Q    LQEK   + + + D
Sbjct  403   EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED  454


>gi|41017595|sp|O95153|RIMB1_HUMAN  Peripheral-type benzodiazepine receptor-associated protein 1 
(PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) 
(PBR-IP) (RIM binding protein 1) (RIM-BP1)
Length=1857

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 23/127 (18%)

Query  1182  EGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEV  1241
             E S L  +   K    W++     ++LR QL  VTQE  D+  ++++GL+ ++ + LE+V
Sbjct  385   ENSRLSGRATEKEQVEWEN-----AELRGQLLGVTQER-DSALRKSQGLQSKL-ESLEQV  437

Query  1242  KAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR  1301
                ++      Q++ Q E+E              E AR  L E QE++  L +   +  R
Sbjct  438   LKHMREVA---QRRQQLEVE-------------HEQARLSLREKQEEVRRLQQAQAEAQR  481

Query  1302  AHVDALR  1308
              H  A++
Sbjct  482   EHEGAVQ  488


>gi|20178341|sp|P47974|TISD_HUMAN  Butyrate response factor 2 (TIS11D protein) (EGF-response factor 
2) (ERF-2)
Length=492

 Score = 29.6 bits (65),  Expect = 9.0
 Identities = 22/81 (27%), Positives = 27/81 (33%), Gaps = 4/81 (4%)

Query  903  PSAHQQPPHYTTSALQQALLSPTPPDYTRHQQPALMHSESMEEDCSCEGAKDGFQDSKSS  962
            PS H QPP      L+  LL  +P   T         S       SC  A      S + 
Sbjct  264  PSGHHQPP----GGLESPLLLDSPTSRTPPPPSCSSASSCSSSASSCSSASAASTPSGAP  319

Query  963  STLTKGCHDSPLLLSTGGPGD  983
            +        + LL  TGG  D
Sbjct  320  TCCASAAAAAALLYGTGGAED  340






  Database: Non-redundant SwissProt sequences
    Posted date:  Mar 15, 2006  2:23 AM
  Number of letters in database: 7,391,856
  Number of sequences in database:  13,628
Lambda     K      H
   0.317    0.132    0.394 
Gapped
Lambda     K      H
   0.267   0.0410    0.140 
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 13628
Number of Hits to DB: 7007
Number of extensions: 336
Number of successful extensions: 0
Number of sequences better than 10: 0
Number of HSP's better than 10 without gapping: 0
Number of HSP's gapped: 0
Number of HSP's successfully gapped: 0
Length of query: 1391
Length of database: 7391856
Length adjustment: 109
Effective length of query: 1282
Effective length of database: 7391856
Effective search space: 9476359392
Effective search space used: 7572009928
T: 11
A: 40
X1: 16 (7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 65 (29.6 bits)







 


 
Format
  


 


 
Show
  Graphical OverviewLinkoutSequence RetrievalNCBI-giAlignmentPSSMBioseq in HTMLPlain textASN.1XMLformat


 


 

  CDS feature


 


 

  Masking CharacterX for protein, n for nucleotideLower Case
Masking ColorBlackGreyRed



 


 
Number of:
  Descriptions010501002505001000
Alignments010501002505001000



 


 
Alignment view
  PairwisePairwise with identitiesquery-anchored with identitiesquery-anchored without identitiesflat query-anchored with identitiesflat query-anchored without identitiesHit Table


 


 
Format for PSI-BLAST
  with inclusion threshold:


 


 
Limit results by entrez query
   or select from:All organismsViruses [ORGN]Archaea [ORGN]Bacteria [ORGN]Eukaryota [ORGN]Viridiplantae [ORGN]Fungi [ORGN]Metazoa [ORGN]Arthropoda [ORGN]Vertebrata [ORGN]Mammalia [ORGN]Rodentia [ORGN]Primates [ORGN]-------------------Aeropyrum pernix [ORGN]Aquifex aeolicus [ORGN]Arabidopsis thaliana [ORGN]Bacillus subtilis [ORGN]Bos taurus [ORGN]Caenorhabditis elegans [ORGN]Canis familiaris[ORGN]Danio rerio [ORGN]Dictyostelium discoideum [ORGN]Drosophila melanogaster [ORGN]Escherichia coli [ORGN]Gallus gallus [ORGN]Homo sapiens [ORGN]Human immunodeficiency virus type 1 [ORGN]Methanococcus jannaschii [ORGN]Mus musculus [ORGN]Oryctolagus cuniculus [ORGN]Oryza sativa [ORGN]Ovis aries [ORGN]Plasmodium falciparum [ORGN]Rattus norvegicus [ORGN]Saccharomyces cerevisiae [ORGN]Schizosaccharomyces pombe [ORGN]Xenopus tropicalis[ORGN]Simian immunodeficiency virus [ORGN]Sus scrofa[ORGN]Synechocystis PCC6803 [ORGN]Takifugu rubripes [ORGN]Xenopus laevis [ORGN]Zea mays [ORGN]


 


 
Expect value range:
    







 or