BLASTP 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman 
(1997), "Gapped BLAST and PSI-BLAST: a new generation of 
protein database search programs", Nucleic Acids Res. 25:3389-3402.

RID: 1143801420-1277-123495994105.BLASTQ1


Database: Non-redundant SwissProt sequences
           195,650 sequences; 73,396,406 total letters
 
If you have any problems or questions with the results of this search 
please refer to the BLAST FAQs
Taxonomy reports


Query=  
Length=1991

                                                                   Score     E
Sequences producing significant alignments:                        (Bits)  Value

gi|74751641|sp|Q8WZ74|CTTB2_HUMAN  Cortactin-binding protein 2 (C  2404    0.0  
gi|20531995|sp|Q8WXK3|ASB13_HUMAN  Ankyrin repeat and SOCS box pr   103    7e-22  
gi|1703310|sp|Q01484|ANK2_HUMAN  Ankyrin-2 (Brain ankyrin) (Ankyr   100    8e-21  
gi|21759000|sp|Q12955|ANK3_HUMAN  Ankyrin-3 (ANK-3) (Ankyrin G)    99.8    1e-20  
gi|113884|sp|P16157|ANK1_HUMAN  Ankyrin-1 (Erythrocyte ankyrin) (  95.1    3e-19  
gi|90109864|sp|Q9ULJ7|ANR50_HUMAN  Ankyrin repeat domain-containi  94.7    3e-19  
gi|57015280|sp|O15084|ANR28_HUMAN  Ankyrin repeat domain-containi  93.2    1e-18  
gi|29839756|sp|Q96DX5|ASB9_HUMAN  Ankyrin repeat and SOCS box pro  92.8    1e-18  
gi|20531999|sp|Q96Q27|ASB2_HUMAN  Ankyrin repeat and SOCS box pro  92.8    1e-18  
gi|68565512|sp|Q86YT6|MIB1_HUMAN  Ubiquitin ligase protein MIB...  90.5    6e-18  
gi|61213006|sp|Q8WXE0|CSKI2_HUMAN  Caskin-2                        90.1    8e-18  
gi|10719883|sp|P57078|RIPK4_HUMAN  Serine/threonine-protein ki...  88.6    2e-17  
gi|20531991|sp|Q8WXI3|ASB10_HUMAN  Ankyrin repeat and SOCS box pr  87.4    5e-17  
gi|61213003|sp|Q8WXD9|CSKI1_HUMAN  Caskin-1 (CASK-interacting pro  87.0    7e-17  
gi|68565551|sp|Q9Y283|INVS_HUMAN  Inversin (Inversion of embryo t  84.3    5e-16  
gi|47117901|sp|Q8WXK1|ASB15_HUMAN  Ankyrin repeat and SOCS box pr  83.6    8e-16  
gi|25090571|sp|Q9H9B1|EHMT1_HUMAN  Histone-lysine N-methyltran...  82.4    2e-15  
gi|20532004|sp|Q9Y575|ASB3_HUMAN  Ankyrin repeat and SOCS box pro  82.4    2e-15  
gi|74762569|sp|Q8NFD2|ANKK1_HUMAN  Ankyrin repeat and protein ...  82.4    2e-15  
gi|20531990|sp|Q8WXH4|ASB11_HUMAN  Ankyrin repeat and SOCS box pr  81.6    3e-15  
gi|38605718|sp|P53355|DAPK1_HUMAN  Death-associated protein kinas  81.6    3e-15  
gi|20532206|sp|O75832|PSD10_HUMAN  26S proteasome non-ATPase r...  80.5    7e-15  
gi|20531989|sp|Q8WWX0|ASB5_HUMAN  Ankyrin repeat and SOCS box pro  79.0    2e-14  
gi|41017262|sp|O14974|MYPT1_HUMAN  Protein phosphatase 1 regul...  78.6    2e-14  
gi|82582303|sp|Q59H18|TNI3K_HUMAN  Serine/threonine-protein ki...  77.4    6e-14
gi|14424230|sp|Q9Y2G4|ANKR6_HUMAN  Ankyrin repeat domain protein   76.6    9e-14  
gi|20140451|sp|O95271|TNKS1_HUMAN  Tankyrase 1 (TANK1) (Tankyr...  75.9    2e-13  
gi|34921898|sp|Q8WWH4|ASZ1_HUMAN  Ankyrin repeat, SAM and basi...  75.9    2e-13  
gi|25089825|sp|Q96KQ7|EHMT2_HUMAN  Histone-lysine N-methyltran...  75.5    2e-13  
gi|62511243|sp|Q92625|ANKS1_HUMAN  Ankyrin repeat and SAM domain-  75.1    3e-13  
gi|22001988|sp|Q9Y566|SHAN1_HUMAN  SH3 and multiple ankyrin re...  74.7    4e-13  
gi|27734215|sp|Q9H9E1|ANRA2_HUMAN  Ankyrin repeat family A protei  73.6    8e-13  
gi|83305683|sp|Q68DC2|SAMD6_HUMAN  Sterile alpha motif domain-...  73.2    1e-12
gi|29839757|sp|Q9H765|ASB8_HUMAN  Ankyrin repeat and SOCS box pro  72.4    2e-12  
gi|56749685|sp|O75762|TRPA1_HUMAN  Transient receptor potentia...  72.4    2e-12  
gi|20140805|sp|Q9H2K2|TNKS2_HUMAN  Tankyrase 2 (TANK2) (Tankyr...  72.0    2e-12  
gi|6093962|sp|O14593|RFXK_HUMAN  DNA-binding protein RFXANK (R...  70.9    5e-12  
gi|50400336|sp|Q6UB99|ANR11_HUMAN  Ankyrin repeat domain prote...  69.3    2e-11  
gi|9973397|sp|Q13418|ILK1_HUMAN  Integrin-linked protein kinas...  68.9    2e-11  
gi|9973390|sp|P57043|ILK2_HUMAN  Integrin-linked protein kinase 2  68.9    2e-11  
gi|20531998|sp|Q96NS5|ASB16_HUMAN  Ankyrin repeat and SOCS box pr  68.6    3e-11  
gi|50400335|sp|Q6UB98|ANR12_HUMAN  Ankyrin repeat domain prote...  68.6    3e-11  
gi|21759004|sp|Q9GZV1|ANKR2_HUMAN  Ankyrin repeat domain prote...  67.8    4e-11  
gi|20139103|sp|Q99466|NOTC4_HUMAN  Neurogenic locus notch homo...  67.4    6e-11  
gi|38372887|sp|Q9H672|ASB7_HUMAN  Ankyrin repeat and SOCS box pro  67.0    8e-11  
gi|114870|sp|P20749|BCL3_HUMAN  B-cell lymphoma 3-encoded protein  65.9    2e-10  
gi|13123980|sp|Q99728|BARD1_HUMAN  BRCA1-associated RING domain p  65.9    2e-10  
gi|55583954|sp|Q8N8V4|HARP_HUMAN  Harmonin-interacting ankyrin re  65.5    2e-10  
gi|62512181|sp|Q8WXK4|ASB12_HUMAN  Ankyrin repeat and SOCS box pr  64.7    4e-10  
gi|20532005|sp|Q9Y576|ASB1_HUMAN  Ankyrin repeat and SOCS box pro  64.3    5e-10  
gi|81175048|sp|Q495M9|USH1G_HUMAN  Usher syndrome type 1G prot...  63.5    8e-10  
gi|20138948|sp|Q04721|NOTC2_HUMAN  Neurogenic locus notch homo...  63.5    8e-10  
gi|46395885|sp|Q8IUH5|ZDH17_HUMAN  Palmitoyltransferase ZDHHC1...  63.2    1e-09  
gi|20137528|sp|Q9NU02|ANKR5_HUMAN  Ankyrin repeat domain protein   63.2    1e-09  
gi|28558073|sp|Q9NXR5|ANR10_HUMAN  Ankyrin repeat domain protein   62.8    1e-09  
gi|34222827|sp|Q86YR6|ANR21_HUMAN  Ankyrin repeat domain prote...  62.8    1e-09  
gi|22256976|sp|Q96I34|PP16A_HUMAN  Protein phosphatase 1 regul...  62.4    2e-09  
gi|55976443|sp|Q6S5H4|POT15_HUMAN  Prostate, ovary, testis expres  62.0    2e-09  
gi|20139284|sp|Q9UM47|NOTC3_HUMAN  Neurogenic locus notch homo...  61.6    3e-09  
gi|55976445|sp|Q6S8J3|POTE2_HUMAN  Prostate, ovary, testis expres  61.6    3e-09  
gi|1350802|sp|Q05823|RN5A_HUMAN  2-5A-dependent ribonuclease (...  61.2    4e-09  
gi|23503070|sp|Q06547|GABP2_HUMAN  GA-binding protein beta cha...  60.8    5e-09  
gi|62900369|sp|Q8TC84|FANK1_HUMAN  Fibronectin type 3 and ankyrin  60.1    9e-09  
gi|73920184|sp|Q14678|ANR15_HUMAN  Ankyrin repeat domain-conta...  59.7    1e-08
gi|6685712|sp|O60733|PA2G6_HUMAN  85 kDa calcium-independent p...  59.3    2e-08  
gi|41017271|sp|O60237|MYPT2_HUMAN  Protein phosphatase 1 regul...  58.9    2e-08  
gi|57012588|sp|Q6W2J9|BCOR_HUMAN  BCoR protein (BCL-6 corepressor  58.9    2e-08  
gi|68565531|sp|Q96AX9|MIB2_HUMAN  Ubiquitin ligase protein MIB...  58.5    3e-08  
gi|33514905|sp|Q9P2R3|ANFY1_HUMAN  Ankyrin repeat and FYVE dom...  58.2    3e-08  
gi|20138912|sp|P58546|MTPN_HUMAN  Myotrophin (V-1 protein)         57.8    5e-08  
gi|55976446|sp|Q6S8J7|POTE8_HUMAN  Prostate, ovary, testis expres  56.6    1e-07  
gi|46395884|sp|Q8IUH4|ZDH13_HUMAN  Probable palmitoyltransfera...  56.6    1e-07  
gi|22256977|sp|Q96T49|PP16B_HUMAN  Protein phosphatase 1 regul...  56.2    1e-07  
gi|20532003|sp|Q9Y574|ASB4_HUMAN  Ankyrin repeat and SOCS box pro  56.2    1e-07  
gi|20141565|sp|P46531|NOTC1_HUMAN  Neurogenic locus notch homo...  56.2    1e-07  
gi|1168870|sp|P42773|CDN2C_HUMAN  Cyclin-dependent kinase 6 in...  55.5    2e-07  
gi|21542418|sp|P19838|NFKB1_HUMAN  Nuclear factor NF-kappa-B p...  55.5    2e-07  
gi|22653655|sp|Q92527|ANKR7_HUMAN  Ankyrin repeat domain prote...  53.9    7e-07  
gi|55976444|sp|Q6S5H5|POT14_HUMAN  Prostate, ovary, testis expres  53.9    7e-07  
gi|85700410|sp|Q9BZ19|CT086_HUMAN  Hypothetical protein C20orf86   52.8    1e-06  
gi|34098677|sp|Q96KQ4|ASPP1_HUMAN  Apoptosis stimulating of p5...  52.4    2e-06  
gi|20143880|sp|Q9BXW6|OSBL1_HUMAN  Oxysterol-binding protein-r...  52.0    3e-06  
gi|33860140|sp|Q13625|ASPP2_HUMAN  Apoptosis-stimulating of p5...  50.8    6e-06  
gi|39931161|sp|Q8IVF6|ANR18_HUMAN  Ankyrin repeat domain protein   50.4    7e-06  
gi|57015399|sp|Q15653|IKBB_HUMAN  NF-kappa-B inhibitor beta (N...  50.1    1e-05  
gi|39932727|sp|Q15057|CENB2_HUMAN  Centaurin-beta 2 (Cnt-b2)       49.7    1e-05  
gi|1346640|sp|P35580|MYH10_HUMAN  Myosin-10 (Myosin heavy chai...  49.3    2e-05  
gi|55976442|sp|Q6S545|POT22_HUMAN  Prostate, ovary, testis expres  49.3    2e-05  
gi|11135426|sp|Q9Y6H5|SNCAP_HUMAN  Synphilin-1 (Alpha-synuclein-i  48.9    2e-05  
gi|20531994|sp|Q8WXK2|ASB14_HUMAN  Ankyrin repeat and SOCS box pr  48.5    3e-05  
gi|3183210|sp|Q15027|CENB1_HUMAN  Centaurin-beta 1 (Cnt-b1)        48.1    4e-05  
gi|6166599|sp|P35579|MYH9_HUMAN  Myosin-9 (Myosin heavy chain,...  47.8    5e-05  
gi|77432385|sp|O00522|KRIT1_HUMAN  Krev interaction trapped pr...  47.8    5e-05  
gi|68565930|sp|Q9BQG2|NUD12_HUMAN  Peroxisomal NADH pyrophosph...  47.0    8e-05  
gi|41688801|sp|Q9NWX5|ASB6_HUMAN  Ankyrin repeat and SOCS box pro  46.2    1e-04  
gi|126682|sp|P25963|IKBA_HUMAN  NF-kappa-B inhibitor alpha (Ma...  45.8    2e-04  
gi|34222508|sp|Q15075|EEA1_HUMAN  Early endosome antigen 1 (En...  45.4    2e-04  
gi|61218305|sp|Q8N961|ABTB2_HUMAN  Ankyrin repeat and BTB/POZ dom  45.1    3e-04  
gi|22654255|sp|Q00653|NFKB2_HUMAN  Nuclear factor NF-kappa-B p...  44.7    4e-04  
gi|11134088|sp|Q92882|OSTF1_HUMAN  Osteoclast-stimulating factor   44.7    4e-04  
gi|30173128|sp|Q9NQS7|INCE_HUMAN  Inner centromere protein         44.3    5e-04  
gi|85682779|sp|Q9ULT8|HECD1_HUMAN  E3 ubiquitin-protein ligase...  44.3    5e-04
gi|27923747|sp|Q96P50|CENB5_HUMAN  Centaurin-beta 5 (Cnt-b5)       43.9    7e-04  
gi|417216|sp|P33176|KINH_HUMAN  Kinesin heavy chain (Ubiquitous k  43.9    7e-04  
gi|28201804|sp|Q14789|GOGB1_HUMAN  Golgin subfamily B member 1...  43.5    9e-04  
gi|32469733|sp|Q8IWJ2|GCC2_HUMAN  GRIP and coiled-coil domain-...  43.5    9e-04  
gi|27923745|sp|Q96P47|CENG3_HUMAN  Centaurin-gamma 3               43.1    0.001  
gi|1345731|sp|P49454|CENPF_HUMAN  CENP-F kinetochore protein (...  43.1    0.001  
gi|14195007|sp|Q15149|PLEC1_HUMAN  Plectin 1 (PLTN) (PCN) (Hemide  42.7    0.002  
gi|14194715|sp|Q92817|EVPL_HUMAN  Envoplakin (210 kDa paraneop...  42.7    0.002  
gi|50403702|sp|O95613|PCNT_HUMAN  Pericentrin (Pericentrin B) (Ke  42.7    0.002  
gi|45645212|sp|Q9Y2X7|GIT1_HUMAN  ARF GTPase-activating protei...  42.4    0.002  
gi|74739242|sp|Q4ZG46|RBP24_HUMAN  Ran-binding protein 2-like 4 (  42.4    0.002
gi|17375490|sp|Q14203|DYNA_HUMAN  Dynactin-1 (150 kDa dynein-a...  42.4    0.002  
gi|62287118|sp|Q96CV9|OPTN_HUMAN  Optineurin (Optic neuropathy...  42.4    0.002  
gi|71152964|sp|Q8WUF5|IASPP_HUMAN  RelA-associated inhibitor (...  42.4    0.002
gi|29427834|sp|Q8N4C8|MINK1_HUMAN  Misshapen-like kinase 1 (Mi...  42.0    0.003  
gi|17376322|sp|Q14161|GIT2_HUMAN  ARF GTPase-activating protei...  41.6    0.003  
gi|30912747|sp|Q9P2S6|ANKY1_HUMAN  Ankyrin repeat and MYND dom...  41.6    0.003  
gi|42558942|sp|O75334|LIPA2_HUMAN  Liprin-alpha-2 (Protein tyr...  41.2    0.004  
gi|33302627|sp|Q15643|TRIPB_HUMAN  Thyroid receptor-interactin...  41.2    0.004  
gi|13431724|sp|Q9Y623|MYH4_HUMAN  Myosin-4 (Myosin heavy chain...  41.2    0.004  
gi|12644407|sp|Q13574|DGKZ_HUMAN  Diacylglycerol kinase zeta (...  41.2    0.004  
gi|74753268|sp|Q9UDT6|CYLN2_HUMAN  Cytoplasmic linker protein ...  40.8    0.006  
gi|50400858|sp|Q14980|NUMA1_HUMAN  Nuclear mitotic apparatus p...  40.8    0.006  
gi|30580364|sp|Q9BV73|CEP2_HUMAN  Centrosomal protein 2 (Centr...  40.8    0.006  
gi|13431717|sp|Q9UKX3|MYH13_HUMAN  Myosin-13 (Myosin heavy cha...  40.8    0.006  
gi|13432177|sp|P35749|MYH11_HUMAN  Myosin-11 (Myosin heavy chain,  40.8    0.006  
gi|62901456|sp|Q8NET8|TRPV3_HUMAN  Transient receptor potentia...  40.8    0.006  
gi|10720353|sp|O15078|CE290_HUMAN  Centrosomal protein Cep290      40.4    0.008  
gi|1705730|sp|P55273|CDN2D_HUMAN  Cyclin-dependent kinase 4 inhib  40.4    0.008  
gi|50400544|sp|Q8IZ07|ANR13_HUMAN  Ankyrin repeat domain-containi  40.4    0.008  
gi|20139283|sp|Q9UL16|CCD19_HUMAN  Coiled-coil domain-containi...  40.0    0.010  
gi|14548073|sp|O00221|IKBE_HUMAN  NF-kappa-B inhibitor epsilon...  40.0    0.010  
gi|14195005|sp|O60437|PEPL_HUMAN  Periplakin (195 kDa cornifie...  40.0    0.010  
gi|27923755|sp|Q9P2M7|CING_HUMAN  Cingulin                         40.0    0.010  
gi|13638390|sp|P12882|MYH1_HUMAN  Myosin-1 (Myosin heavy chain...  39.7    0.013  
gi|266902|sp|P30622|REST_HUMAN  Restin (Cytoplasmic linker pro...  39.7    0.013  
gi|14194461|sp|Q99996|AKAP9_HUMAN  A-kinase anchor protein 9 (...  39.7    0.013  
gi|47117278|sp|Q96R06|SPAG5_HUMAN  Sperm-associated antigen 5 ...  39.3    0.017  
gi|1730009|sp|P12270|TPR_HUMAN  Nucleoprotein TPR                  39.3    0.017  
gi|62288025|sp|Q66GS9|CEP4_HUMAN  Centrosomal protein 4 (Centr...  39.3    0.017  
gi|32470610|sp|Q08378|GOGA3_HUMAN  Golgin subfamily A member 3...  38.9    0.022  
gi|83304912|sp|P12883|MYH7_HUMAN  Myosin heavy chain, cardiac mus  38.9    0.022
gi|48474259|sp|O43150|DDEF2_HUMAN  Development and differentia...  38.9    0.022  
gi|67476728|sp|P42566|EP15_HUMAN  Epidermal growth factor rece...  38.5    0.029
gi|55583998|sp|Q9NUQ3|TXLNG_HUMAN  Gamma-taxilin (Lipopolysacchar  38.5    0.029  
gi|50400977|sp|Q7Z4S6|KI21A_HUMAN  Kinesin family member 21A (...  38.5    0.029  
gi|18202960|sp|Q9HCX4|TRPC7_HUMAN  Short transient receptor po...  38.5    0.029  
gi|29840818|sp|Q9UKE5|TNIK_HUMAN  TRAF2 and NCK-interacting kinas  38.1    0.037  
gi|23822112|sp|Q9P2E9|RRBP1_HUMAN  Ribosome-binding protein 1 ...  38.1    0.037  
gi|50403793|sp|Q96L93|SNX23_HUMAN  Kinesin-like motor protein C20  38.1    0.037  
gi|3041706|sp|P13533|MYH6_HUMAN  Myosin heavy chain, cardiac musc  38.1    0.037  
gi|29427585|sp|O95819|M4K4_HUMAN  Mitogen-activated protein ki...  38.1    0.037  
gi|42558938|sp|Q8TD31|CCHCR_HUMAN  Coiled-coil alpha-helical r...  37.7    0.049  
gi|32699595|sp|Q96CN9|GCC1_HUMAN  GRIP and coiled-coil domain-...  37.7    0.049  
gi|55584162|sp|P40222|TXLNA_HUMAN  Alpha-taxilin                   37.7    0.049  
gi|6686048|sp|Q9Y210|TRPC6_HUMAN  Short transient receptor potent  37.7    0.049  
gi|3043372|sp|P11055|MYH3_HUMAN  Myosin heavy chain, fast skel...  37.7    0.049  
gi|77416379|sp|Q9UPN4|AZI1_HUMAN  5-azacytidine-induced protei...  37.7    0.049  
gi|62512161|sp|O95239|KIF4A_HUMAN  Chromosome-associated kinesin   37.4    0.064  
gi|71153214|sp|Q68D86|CR014_HUMAN  Hypothetical protein C18orf14   37.4    0.064  
gi|10720321|sp|Q9UL62|TRPC5_HUMAN  Short transient receptor po...  37.0    0.083  
gi|62899891|sp|Q9HC77|CENPJ_HUMAN  Centromere protein J (Centr...  37.0    0.083  
gi|52783153|sp|Q9Y6D9|MD1L1_HUMAN  Mitotic spindle assembly ch...  37.0    0.083  
gi|51827892|sp|Q8IUD2|RB6I2_HUMAN  RAB6-interacting protein 2 (ER  37.0    0.083  
gi|42558987|sp|Q8ND30|LIPB2_HUMAN  Liprin-beta-2 (Protein tyro...  37.0    0.083  
gi|68840132|sp|Q96SN8|CK5P2_HUMAN  CDK5 regulatory subunit-ass...  37.0    0.083
gi|2833266|sp|Q15696|U2AFM_HUMAN  U2 small nuclear ribonucleop...  36.6    0.11   
gi|32470611|sp|Q08379|GOGA2_HUMAN  Golgin subfamily A member 2...  36.6    0.11   
gi|12643721|sp|Q13507|TRPC3_HUMAN  Short transient receptor po...  36.6    0.11   
gi|134517|sp|P12755|SKI_HUMAN  Ski oncogene (C-ski)                36.6    0.11   
gi|55976584|sp|Q9BYJ4|TRI34_HUMAN  Tripartite motif protein 34...  36.6    0.11   
gi|46396998|sp|Q96T51|RUFY1_HUMAN  RUN and FYVE domain-contain...  36.6    0.11   
gi|32699565|sp|Q8IUG5|MY18B_HUMAN  Myosin-18B (Myosin XVIIIb)      36.6    0.11   
gi|20141591|sp|Q15811|ITSN1_HUMAN  Intersectin-1 (SH3 domain-cont  36.6    0.11   
gi|134594|sp|P12757|SKIL_HUMAN  Ski-like protein (Ski-related pro  36.2    0.14   
gi|71151982|sp|Q7Z406|MYH14_HUMAN  Myosin-14 (Myosin heavy cha...  36.2    0.14   
gi|90185247|sp|Q86W92|LIPB1_HUMAN  Liprin-beta-1 (Protein tyro...  36.2    0.14 
gi|56405385|sp|Q9HCM9|TRI39_HUMAN  Tripartite motif protein 39...  35.8    0.19   
gi|74762068|sp|Q9Y5S2|MRCKB_HUMAN  Serine/threonine-protein ki...  35.8    0.19   
gi|20138952|sp|Q15025|NAF1_HUMAN  Nef-associated factor 1 (Naf...  35.8    0.19   
gi|13124651|sp|Q9NX95|K1472_HUMAN  Protein KIAA1472                35.8    0.19   
gi|62286928|sp|Q7Z6B0|GGABP_HUMAN  GGA-binding partner (p56 acces  35.8    0.19   
gi|34098604|sp|Q8TD16|BICD2_HUMAN  Cytoskeleton-like bicaudal D p  35.8    0.19   
gi|3041707|sp|P13535|MYH8_HUMAN  Myosin-8 (Myosin heavy chain,...  35.8    0.19   
gi|62901469|sp|Q9H1D0|TRPV6_HUMAN  Transient receptor potentia...  35.8    0.19   
gi|127234|sp|P26038|MOES_HUMAN  Moesin (Membrane-organizing exten  35.8    0.19   
gi|13431939|sp|Q9Y6A5|TACC3_HUMAN  Transforming acidic coiled-coi  35.8    0.19   
gi|14195666|sp|O60841|IF2P_HUMAN  Eukaryotic translation initi...  35.8    0.19   
gi|47605963|sp|O75116|ROCK2_HUMAN  Rho-associated protein kina...  35.4    0.24   
gi|25009267|sp|Q9H078|CLPB_HUMAN  Caseinolytic peptidase B pro...  35.4    0.24   
gi|84027766|sp|Q5VTR2|BRE1A_HUMAN  Ubiquitin-protein ligase BR...  35.4    0.24 
gi|12644130|sp|P15924|DESP_HUMAN  Desmoplakin (DP) (250/210 kDa p  35.4    0.24   
gi|62901471|sp|Q9NQA5|TRPV5_HUMAN  Transient receptor potentia...  35.4    0.24   
gi|586120|sp|Q07283|TRHY_HUMAN  Trichohyalin                       35.4    0.24   
gi|12643718|sp|Q13439|GOGA4_HUMAN  Golgin subfamily A member 4...  35.4    0.24   
gi|51315800|sp|Q9UPA5|BSN_HUMAN  Bassoon protein (Zinc-finger pro  35.4    0.24   
gi|57012622|sp|Q9P2G1|AKIB1_HUMAN  Ankyrin repeat and IBR domain-  35.4    0.24   
gi|57015410|sp|Q8NDV3|SM1L2_HUMAN  Structural maintenance of c...  35.4    0.24   
gi|13431716|sp|Q9UKX2|MYH2_HUMAN  Myosin heavy chain, skeletal...  35.0    0.32   
gi|12643642|sp|O75912|DGKI_HUMAN  Diacylglycerol kinase iota (...  35.0    0.32   
gi|67460585|sp|Q9BUQ8|DDX23_HUMAN  Probable ATP-dependent RNA ...  35.0    0.32   
gi|74759012|sp|Q7L7X3|TAOK1_HUMAN  Serine/threonine-protein ki...  35.0    0.32   
gi|399227|sp|Q02224|CENPE_HUMAN  Centromeric protein E (CENP-E pr  35.0    0.32   
gi|2833265|sp|Q15695|U2AFL_HUMAN  U2 small nuclear ribonucleop...  35.0    0.32   
gi|84027768|sp|O75150|BRE1B_HUMAN  Ubiquitin-protein ligase BR...  35.0    0.32 
gi|74728485|sp|Q8N137|LIP8_HUMAN  Centrobin (LYST-interacting pro  35.0    0.32   
gi|71152997|sp|Q7Z3E2|CJ118_HUMAN  Protein C10orf118 (CTCL tumor   35.0    0.32   
gi|27923959|sp|Q03001|BPA1_HUMAN  Bullous pemphigoid antigen 1...  35.0    0.32   
gi|42558941|sp|O75145|LIPA3_HUMAN  Liprin-alpha-3 (Protein tyr...  34.7    0.41   
gi|32469749|sp|Q8TBA6|GOGA5_HUMAN  Golgin subfamily A member 5...  34.7    0.41   
gi|62286590|sp|O94986|CE152_HUMAN  Centrosomal protein of 152 kDa  34.7    0.41   
gi|131011|sp|P10162|PRB4L_HUMAN  Basic salivary proline-rich p...  34.7    0.41   
gi|731165|sp|Q02040|XE7_HUMAN  B-lymphocyte antigen precursor ...  34.7    0.41   
gi|74753569|sp|Q4V328|GRAP1_HUMAN  GRIP1-associated protein 1 (GR  34.7    0.41   
gi|50400772|sp|Q8N4C6|NIN_HUMAN  Ninein (hNinein)                  34.7    0.41   
gi|74713839|sp|Q86SQ7|SDCG8_HUMAN  Serologically defined colon...  34.7    0.41   
gi|6176569|sp|Q99490|CENG1_HUMAN  Centaurin-gamma 1                34.3    0.54   
gi|13124654|sp|Q9UPV9|OI106_HUMAN  106 kDa O-GlcNAc transferas...  34.3    0.54   
gi|44887818|sp|Q96NX9|DACH2_HUMAN  Dachshund homolog 2 (Dach2)     34.3    0.54   
gi|13124704|sp|Q14457|BCN1_HUMAN  Beclin-1 (Coiled-coil myosin...  34.3    0.54   
gi|32469788|sp|Q9NYA3|GOGA6_HUMAN  Golgin subfamily A member 6...  34.3    0.54   
gi|41688592|sp|Q96ED9|HOOK2_HUMAN  Hook homolog 2 (h-hook2) (hHK2  34.3    0.54   
gi|60392986|sp|Q92878|RAD50_HUMAN  DNA repair protein RAD50 (hRAD  33.9    0.71   
gi|3913958|sp|O15066|KIF3B_HUMAN  Kinesin-like protein KIF3B (...  33.9    0.71   
gi|13633994|sp|Q9UBN4|TRPC4_HUMAN  Short transient receptor po...  33.9    0.71   
gi|1709020|sp|P41594|MGR5_HUMAN  Metabotropic glutamate receptor   33.9    0.71   
gi|3024609|sp|Q15431|SYCP1_HUMAN  Synaptonemal complex protein 1   33.9    0.71   
gi|30912698|sp|Q8NB25|CF060_HUMAN  Hypothetical protein C6orf60    33.9    0.71   
gi|22653668|sp|Q9UIF8|BAZ2B_HUMAN  Bromodomain adjacent to zinc f  33.9    0.71   
gi|46396501|sp|Q9BRK4|LZTS2_HUMAN  Leucine zipper putative tumor   33.5    0.92   
gi|38605068|sp|Q9NSC5|HOME3_HUMAN  Homer protein homolog 3 (Homer  33.5    0.92   
gi|33301318|sp|Q92614|MY18A_HUMAN  Myosin-18A (Myosin XVIIIa) ...  33.5    0.92   
gi|34582329|sp|Q96BM1|ANKR9_HUMAN  Ankyrin repeat domain protein   33.5    0.92   
gi|6685537|sp|Q14152|IF3A_HUMAN  Eukaryotic translation initia...  33.5    0.92   
gi|117424|sp|P23508|CRCM_HUMAN  Colorectal mutant cancer protein   33.5    0.92   
gi|74749769|sp|Q71F56|T240L_HUMAN  Thyroid hormone receptor-as...  33.5    0.92   
gi|13431713|sp|Q9NQX4|MYO5C_HUMAN  Myosin-5C (Myosin Vc)           33.5    0.92   
gi|51701377|sp|O15083|ERC2_HUMAN  ERC protein 2                    33.5    0.92   
gi|84029396|sp|Q86SQ0|PHLB2_HUMAN  Pleckstrin homology-like do...  33.5    0.92   
gi|51338837|sp|Q9UPQ3|CENG2_HUMAN  Centaurin-gamma 2 (ARF-GAP ...  33.5    0.92 
gi|14424221|sp|O75154|RFIP3_HUMAN  Rab11 family-interacting pr...  33.1    1.2    
gi|42558969|sp|Q13136|LIPA1_HUMAN  Liprin-alpha-1 (Protein tyr...  33.1    1.2    
gi|12643336|sp|Q9UI32|GLSL_HUMAN  Glutaminase liver isoform, m...  33.1    1.2    
gi|47605999|sp|Q13464|ROCK1_HUMAN  Rho-associated protein kina...  33.1    1.2    
gi|13431923|sp|O95359|TACC2_HUMAN  Transforming acidic coiled-...  33.1    1.2    
gi|464541|sp|P35241|RADI_HUMAN  Radixin                            33.1    1.2    
gi|2497520|sp|Q12840|KINN_HUMAN  Neuronal kinesin heavy chain ...  33.1    1.2    
gi|57015279|sp|O14578|CTRO_HUMAN  Citron Rho-interacting kinas...  33.1    1.2    
gi|34098691|sp|Q9BVG8|KIFC3_HUMAN  Kinesin-like protein KIFC3      33.1    1.2    
gi|22653669|sp|Q9UIF9|BAZ2A_HUMAN  Bromodomain adjacent to zin...  33.1    1.2    
gi|51704330|sp|Q93045|STMN2_HUMAN  Stathmin-2 (SCG10 protein) ...  32.7    1.6    
gi|119717|sp|P15311|EZRI_HUMAN  Ezrin (p81) (Cytovillin) (Villin-  32.7    1.6    
gi|30173386|sp|Q9NTJ3|SMC4_HUMAN  Structural maintenance of ch...  32.7    1.6    
gi|71153197|sp|Q6ZU80|CN145_HUMAN  Protein C14orf145               32.7    1.6    
gi|67472677|sp|Q16181|SEPT7_HUMAN  Septin-7 (CDC10 protein homolo  32.7    1.6  
gi|13431722|sp|Q9Y4I1|MYO5A_HUMAN  Myosin-5A (Myosin Va) (Dilu...  32.7    1.6    
gi|12644018|sp|P55196|AFAD_HUMAN  Afadin (AF-6 protein)            32.7    1.6    
gi|25090013|sp|Q9NVP4|CT012_HUMAN  Protein C20orf12                32.7    1.6    
gi|73920186|sp|P48634|BAT2_HUMAN  Large proline-rich protein BAT2  32.3    2.1  
gi|38605067|sp|Q9NSB8|HOME2_HUMAN  Homer protein homolog 2 (Homer  32.3    2.1    
gi|24418846|sp|O60296|AL2S3_HUMAN  Amyotrophic lateral scleros...  32.3    2.1    
gi|78099183|sp|Q9H2K8|TAOK3_HUMAN  Serine/threonine-protein ki...  32.3    2.1    
gi|20137255|sp|O14617|AP3D1_HUMAN  AP-3 complex subunit delta-...  32.3    2.1    
gi|82581558|sp|Q8TDY2|RBCC1_HUMAN  RB1-inducible coiled-coil prot  32.3    2.1  
gi|1703194|sp|P51825|AFF1_HUMAN  AF4/FMR2 family member 1 (AF-...  32.3    2.1    
gi|12644112|sp|P10070|GLI2_HUMAN  Zinc finger protein GLI2 (Tax h  32.3    2.1    
gi|2494484|sp|Q12778|FOXO1_HUMAN  Forkhead box protein O1A (Forkh  32.3    2.1    
gi|46396456|sp|Q8IY33|MILK2_HUMAN  MICAL-like protein 2            32.3    2.1    
gi|6226826|sp|O75330|HMMR_HUMAN  Hyaluronan mediated motility ...  32.3    2.1    
gi|17433142|sp|Q9HD67|MYO10_HUMAN  Myosin-10 (Myosin X)            32.3    2.1    
gi|128147|sp|P07197|NFM_HUMAN  Neurofilament triplet M protein...  32.0    2.7    
gi|56748768|sp|Q86XR8|CEP57_HUMAN  Centrosomal protein of 57 k...  32.0    2.7    
gi|41688595|sp|Q9UJC3|HOOK1_HUMAN  Hook homolog 1 (h-hook1) (hHK1  32.0    2.7    
gi|41016926|sp|Q9H9C1|CN133_HUMAN  Protein C14orf133               32.0    2.7    
gi|131005|sp|P10163|PRB4S_HUMAN  Basic salivary proline-rich p...  32.0    2.7    
gi|74757248|sp|Q5ZPR3|CD276_HUMAN  CD276 antigen precursor (Co...  32.0    2.7    
gi|52783106|sp|O95835|LATS1_HUMAN  Serine/threonine-protein ki...  32.0    2.7    
gi|48428086|sp|Q8N8S7|ENAH_HUMAN  Protein enabled homolog          32.0    2.7    
gi|3023440|sp|Q92793|CBP_HUMAN  CREB-binding protein               32.0    2.7    
gi|20138768|sp|Q9NZM3|ITSN2_HUMAN  Intersectin-2 (SH3 domain-c...  32.0    2.7    
gi|73620945|sp|O94833|BPAEA_HUMAN  Bullous pemphigoid antigen ...  32.0    2.7  
gi|48428650|sp|Q8N3V7|SYNPO_HUMAN  Synaptopodin                    32.0    2.7    
gi|51338794|sp|P78559|MAP1A_HUMAN  Microtubule-associated prot...  32.0    2.7    
gi|73920185|sp|O14497|ARI1A_HUMAN  AT-rich interactive domain-...  31.6    3.5  
gi|74747076|sp|Q5VUA4|ZN318_HUMAN  Zinc finger protein 318 (Endoc  31.6    3.5    
gi|33860183|sp|Q9UM54|MYO6_HUMAN  Myosin-6 (Myosin VI)             31.6    3.5    
gi|67472134|sp|Q86YS3|RFIP4_HUMAN  Rab11 family-interacting prote  31.6    3.5    
gi|73921750|sp|Q9H307|PININ_HUMAN  Pinin (140 kDa nuclear and ...  31.6    3.5    
gi|731046|sp|P40818|UBP8_HUMAN  Ubiquitin carboxyl-terminal hy...  31.6    3.5    
gi|14286071|sp|Q9P2G4|K1383_HUMAN  Protein KIAA1383                31.6    3.5    
gi|85681028|sp|Q13948|CASP_HUMAN  Protein CASP                     31.6    3.5  
gi|74746874|sp|Q5VT25|MRCKA_HUMAN  Serine/threonine-protein ki...  31.6    3.5    
gi|22653665|sp|Q9NRL2|BAZ1A_HUMAN  Bromodomain adjacent to zin...  31.6    3.5    
gi|76803552|sp|P39880|CUTL1_HUMAN  Homeobox protein cut-like 1 (C  31.6    3.5  
gi|90101763|sp|Q6N043|SUHW4_HUMAN  Suppressor of hairy wing homol  31.6    3.5  
gi|17366834|sp|Q9H251|CAD23_HUMAN  Cadherin-23 precursor (Otocadh  31.2    4.6    
gi|12643319|sp|O75665|OFD1_HUMAN  Oral-facial-digital syndrome 1   31.2    4.6    
gi|6225268|sp|O60610|DIAP1_HUMAN  Protein diaphanous homolog 1...  31.2    4.6    
gi|2498281|sp|Q16204|CCDC6_HUMAN  Coiled-coil domain-containin...  31.2    4.6    
gi|17373489|sp|Q13111|CAF1A_HUMAN  Chromatin assembly factor 1...  31.2    4.6    
gi|62901477|sp|Q9Y5S1|TRPV2_HUMAN  Transient receptor potentia...  31.2    4.6    
gi|55976299|sp|Q14134|TRI29_HUMAN  Tripartite motif protein 29...  31.2    4.6    
gi|29427676|sp|Q16891|IMMT_HUMAN  Mitochondrial inner membrane...  31.2    4.6    
gi|12643557|sp|O43318|M3K7_HUMAN  Mitogen-activated protein ki...  31.2    4.6    
gi|20137932|sp|Q9BXL6|CAR14_HUMAN  Caspase recruitment domain-...  31.2    4.6    
gi|71658803|sp|Q6TFL3|CI093_HUMAN  Protein C9orf93                 31.2    4.6    
gi|56405387|sp|Q9UPN3|MACF1_HUMAN  Microtubule-actin crosslink...  30.8    6.0    
gi|3287764|sp|O43186|CRX_HUMAN  Cone-rod homeobox protein          30.8    6.0    
gi|17865470|sp|Q9NZW4|DSPP_HUMAN  Dentin sialophosphoprotein p...  30.8    6.0    
gi|1708932|sp|P51948|MAT1_HUMAN  CDK-activating kinase assembl...  30.8    6.0    
gi|74733576|sp|Q9H3R5|CENPH_HUMAN  Centromere protein H (Kinetoch  30.8    6.0    
gi|12644533|sp|P57682|KLF3_HUMAN  Kruppel-like factor 3 (Basic...  30.8    6.0    
gi|24636785|sp|Q9UER7|DAXX_HUMAN  Death domain-associated prot...  30.8    6.0    
gi|21362894|sp|O76064|RNF8_HUMAN  Ubiquitin ligase protein RNF8 (  30.8    6.0    
gi|20140360|sp|O15240|VGF_HUMAN  Neurosecretory protein VGF precu  30.8    6.0    
gi|74762299|sp|Q6DT37|MRCKG_HUMAN  Serine/threonine-protein ki...  30.8    6.0    
gi|30316105|sp|Q96PK2|MACF4_HUMAN  Microtubule-actin crosslinking  30.8    6.0    
gi|42559898|sp|Q9UBT2|ULE1B_HUMAN  Ubiquitin-like 1-activating...  30.4    7.8    
gi|85681926|sp|Q9Y426|CU025_HUMAN  Protein C21orf25 precursor      30.4    7.8  
gi|74745646|sp|Q5T9A4|ATD3B_HUMAN  ATPase family AAA domain-conta  30.4    7.8    
gi|84028405|sp|Q9NVI7|ATD3A_HUMAN  ATPase family AAA domain-conta  30.4    7.8  
gi|17367909|sp|O15259|NPHP1_HUMAN  Nephrocystin-1 (Juvenile nephr  30.4    7.8    
gi|114033|sp|P25054|APC_HUMAN  Adenomatous polyposis coli protein  30.4    7.8    
gi|17369320|sp|Q9NRC6|SPTN5_HUMAN  Spectrin beta chain, brain ...  30.4    7.8    
gi|50403806|sp|Q9ULJ8|NEB1_HUMAN  Neurabin-1 (Neurabin-I) (Neu...  30.4    7.8    
gi|76803557|sp|P11532|DMD_HUMAN  Dystrophin                        30.4    7.8  

Alignments

>gi|74751641|sp|Q8WZ74|CTTB2_HUMAN  Cortactin-binding protein 2 (CortBP2)
Length=1663

 Score = 2404 bits (6230),  Expect = 0.0
 Identities = 1403/1773 (79%), Positives = 1459/1773 (82%), Gaps = 178/1773 (10%)

Query  260   KKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQ  319
             KKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALR               ARRKEVFIQ
Sbjct  28    KKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALR---------------ARRKEVFIQ  72

Query  320   ERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAA  379
             ERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAA
Sbjct  73    ERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAA  132

Query  380   ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKL  439
             ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKL
Sbjct  133   ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKL  192

Query  440   EDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHT  499
             EDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHT
Sbjct  193   EDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHT  252

Query  500   TDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLV  559
             TDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLV
Sbjct  253   TDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLV  312

Query  560   TENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPA  619
             TENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPA
Sbjct  313   TENADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPA  372

Query  620   FPPPSANKIEENGpstgstpdptsstpplpsnaapptaQTPGIAPQNSQAPPMHSLHSPC  679
             FPPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNSQAPPMHSLHSPC
Sbjct  373   FPPPSANKIEENGPSTGSTPDPTSSTPPLPSNAAPPTAQTPGIAPQNSQAPPMHSLHSPC  432

Query  680   ANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTV  739
             ANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTV
Sbjct  433   ANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTV  492

Query  740   TQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNpppippkkpGL  799
             TQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNPPPIPPKKPGL
Sbjct  493   TQALSRFTSPQAGAPSRPGVPPTGDVGTHPPVGRTSLKTHGVARVDRGNPPPIPPKKPGL  552

Query  800   SQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINEENlpkssspqlp  859
             SQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINEENLPKSSSPQLP
Sbjct  553   SQTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINEENLPKSSSPQLP  612

Query  860   pkpsIDLTVAPAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVS  919
             PKPSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQ                        
Sbjct  613   PKPSIDLTVAPAGCAVSALATSQVGAWPAATPGLNQ------------------------  648

Query  920   ASSCRPGASDSLLV--TASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLL  977
                  P  SDS LV  T   +  S+ P+  S                             
Sbjct  649   -----PACSDSSLVIPTTIAFCSSINPVSAS-----------------------------  674

Query  978   NEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHF  1037
                      SC  G S       +G +  +  LL +      A +   T L  AAAQG+ 
Sbjct  675   ---------SCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP--TLLQQAAAQGNV  723

Query  1038  ECVELLISYDA-NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHA  1096
               + +L++ +  +IN++ + G + LY A KNG+ +C++LLL A    +    +G+TP+ A
Sbjct  724   TLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCA  783

Query  1097  AVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPADLINHA  1156
             A   G+ + ++LL+                    +D +                  INHA
Sbjct  784   AAAQGHFECVELLIS-------------------YDAN------------------INHA  806

Query  1157  NREGWTAAHIAASKGFKDCNLPDALLAFSHMRVRRFYSHCSSHLGPPGGIHELSGLGVST  1216
                G T  ++A   G K+C +   L A ++  V+        H     G  +   L +  
Sbjct  807   ADGGQTPLYLACKNGNKEC-IKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  865

Query  1217  EFPGHWYLASQ-----LCLKEPGTSLTPQPLLCPWSIVTDPSVSAGPMGTQHKDSILQSP  1271
               P H    ++           G   +P+        ++ P V A        D I  + 
Sbjct  866   RIPAHGNSFNEEESESSVFDLDGGEESPEG-------ISKPVVPA--------DLINHAN  910

Query  1272  LQGTMAKYLSSGK-WNNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKI  1330
              +G  A ++++ K + NCLEILCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKI
Sbjct  911   REGWTAAHIAASKGFKNCLEILCRHGGLEPERRDKCNRTVHDVATDDCKHLLENLNALKI  970

Query  1331  PLRISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNHFQAISSDGWW  1390
             PLRISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNHFQAISSDGWW
Sbjct  971   PLRISVGEIEPSNYGSDDLECENTICALNIRKQTSWDDFSKAVSQALTNHFQAISSDGWW  1030

Query  1391  SLEDVTCNNTTDSNIGLSARSIRSITLG--------------------------------  1418
             SLEDVTCNNTTDSNIGLSARSIRSITLG                                
Sbjct  1031  SLEDVTCNNTTDSNIGLSARSIRSITLGNVPWSVGQSFAQSPWDFMRKNKAEHITVLLSG  1090

Query  1419  PQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMA  1478
             PQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMA
Sbjct  1091  PQEGCLSSVTYASMIPLQMMQNYLRLVEQYHNVIFHGPEGSLQDYIVHQLALCLKHRQMA  1150

Query  1479  AGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSkkkiiiilenleksslsellR  1538
             AGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEKSSLSELLR
Sbjct  1151  AGFSCEIVRAEVDAGFSKEQLLDLFISSACLIPVKQSPSKKKIIIILENLEKSSLSELLR  1210

Query  1539  DFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQL  1598
             DFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQL
Sbjct  1211  DFLAPLENRSTESPCTFQKGNGLSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQL  1270

Query  1599  RWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEA  1658
             RWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEA
Sbjct  1271  RWDGEPMQGLLQRFLRRKVVNKFKGQAPSPCDPVCKIVDWALSVWRQLNSCLARLGTPEA  1330

Query  1659  LLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKRQPGFGQTTAKRH  1718
             LLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKRQPGFGQTTAKRH
Sbjct  1331  LLGPKYFLSCPVVPGHAQVTVKWMSKLWNGVIAPRVQEAILSRASVKRQPGFGQTTAKRH  1390

Query  1719  PSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSIVSSYNTCNKKKG  1778
             PSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSIVSSYNTCNKKKG
Sbjct  1391  PSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHTADFKGGSFPLSIVSSYNTCNKKKG  1450

Query  1779  ESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNCNRNASLSKQKSLENDL  1838
             ESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNCNRNASLSKQKSLENDL
Sbjct  1451  ESGAWRKVNTSPRRKSGRFSLPTWNKPDLSTEGMKNKTISQLNCNRNASLSKQKSLENDL  1510

Query  1839  SLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFDSSGNNPVLSA  1898
             SLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFDSSGNNPVLSA
Sbjct  1511  SLTLNLDQRLSLGSDDEADLVKELQSMCSSKSESDISKIADSRDDLRMFDSSGNNPVLSA  1570

Query  1899  TINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKVTQCsqntkrs  1958
             TINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKVTQCSQNTKRS
Sbjct  1571  TINNLRMPVSQKEVSPLSSHQTTECSNSKSKTELGVSRVKSFLPVPRSKVTQCSQNTKRS  1630

Query  1959  ssssntrqIEINNNSKEVNWNLHKNEHLEKPNK  1991
             SSSSNTRQIEINNNSKEVNWNLHKNEHLEKPNK
Sbjct  1631  SSSSNTRQIEINNNSKEVNWNLHKNEHLEKPNK  1663


>gi|20531995|sp|Q8WXK3|ASB13_HUMAN  Ankyrin repeat and SOCS box protein 13 (ASB-13)
Length=278

 Score =  103 bits (257),  Expect = 7e-22
 Identities = 58/152 (38%), Positives = 89/152 (58%), Gaps = 2/152 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T + +AA +G    L  L+ E G  +N    D  + L++A+  G   CV+LLL+A AQV+
Sbjct  21    TPVHEAAQRGESLQLQQLI-ESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVD  79

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A + +G TPLC A A G  ECV+LL+SY A +N       +PL+ AC +G+ EC++LL++
Sbjct  80    ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTA-SPLHEACMSGSSECVRLLID  138

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G N         TP+H A    ++D +K+L+
Sbjct  139   VGANLEAHDCHFGTPLHVACAREHLDCVKVLL  170


 Score = 76.6 bits (187),  Expect = 9e-14
 Identities = 66/213 (30%), Positives = 104/213 (48%), Gaps = 10/213 (4%)

Query  883   VGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSL  942
             VG W   TP +++ A    SL +   I   + +N V+  S  P  + SL     G +  +
Sbjct  14    VGFWVERTP-VHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASL----QGQARCV  68

Query  943   TPLLMSGGPAPLAG--RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK  1000
               LL +G           T L  A A G++  + +LL+  G  +N       S L+ A  
Sbjct  69    QLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSY-GAKVNPPLYTA-SPLHEACM  126

Query  1001  NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP  1060
             +G ++CVRLL+   A + A D +  TPL  A A+ H +CV++L++  AN+N AA   +T 
Sbjct  127   SGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVN-AAKLHETA  185

Query  1061  LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP  1093
             L+ A K  N + I++L+E G N   +   G  P
Sbjct  186   LHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP  218


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 0/53 (0%)

Query  1058  QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             +TP++ A + G    ++ L+E+G   +  T D  TP+HAA   G    ++LL+
Sbjct  20    RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLL  72


>gi|1703310|sp|Q01484|ANK2_HUMAN  Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
Length=3924

 Score =  100 bits (248),  Expect = 8e-21
 Identities = 70/215 (32%), Positives = 115/215 (53%), Gaps = 13/215 (6%)

Query  963   QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK  1022
             +AA  GN+  +   L + G+DIN   ++G +AL+ AAK GH   V+ LL   + V++A K
Sbjct  37    RAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK  95

Query  1023  NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN  1082
              G T L  A+  G  E V++L+   ANIN  +  G TPLY+A +  + + +K LLE G N
Sbjct  96    KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN  155

Query  1083  RSVKTTDGWTPVHAAVDTGNVDSLKLLMYH------RIPAHGnsfneeesessVFDLDGG  1136
             +S  T DG+TP+  A+  G+  ++ +L+ +      R+PA   +  +++++S+   L   
Sbjct  156   QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND  215

Query  1137  EESPEGISKPVVPADLINHANREGWTAAHIAASKG  1171
               +       V    ++N     G+T  HIAA  G
Sbjct  216   HNA------DVQSKMMVNRTTESGFTPLHIAAHYG  244


 Score = 93.6 bits (231),  Expect = 8e-19
 Identities = 68/213 (31%), Positives = 106/213 (49%), Gaps = 7/213 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T +  AA  G++ ++ +LL + G   + +   G +AL+ AA+ G  + VR LL   A V+
Sbjct  433   TPIHVAAFMGHLNIVLLLL-QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD  491

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  +   TPL  A+  G  E V+LL+ + A+ + A   G TPL+++ + G  +   +LLE
Sbjct  492   ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE  551

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEE  1138
             AG   S+ T  G+TP+H A   G++D  KLL+  R  A     N           D  + 
Sbjct  552   AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV  611

Query  1139  SPEGISKPVVPADLINHAN-REGWTAAHIAASK  1170
             +   + K   P     HA  + G+T  HIAA K
Sbjct  612   ALLLLEKGASP-----HATAKNGYTPLHIAAKK  639


 Score = 93.6 bits (231),  Expect = 8e-19
 Identities = 62/197 (31%), Positives = 98/197 (49%), Gaps = 4/197 (2%)

Query  919   SASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP---TLLQQAAAQGNVTLLSM  975
             +A S        L V A   +  +  LL+  G +P A      T L  AA +  + + S 
Sbjct  588   AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST  647

Query  976   LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG  1035
             LLN  G + N   + G + L+ A++ GHTD V LLL   A ++ + K+G T L  AA + 
Sbjct  648   LLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED  706

Query  1036  HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH  1095
                  ++L  + A+ +     G TPL +AC  GN + +  LL+ G N + KT +G+TP+H
Sbjct  707   KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH  766

Query  1096  AAVDTGNVDSLKLLMYH  1112
              A   G+   + +L+ H
Sbjct  767   QAAQQGHTHIINVLLQH  783


 Score = 91.3 bits (225),  Expect = 4e-18
 Identities = 55/155 (35%), Positives = 86/155 (55%), Gaps = 1/155 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  GNV + ++LLN  G  ++++  +G + L+ A+K G+T+ V+LLL    Q++
Sbjct  235   TPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID  293

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  ++G TPL  AA  GH + VELL+   A +      G +PL++A +  + EC+K LL+
Sbjct  294   AKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ  353

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
                     T D  T +H A   G+    KLL+  R
Sbjct  354   HKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKR  388


 Score = 87.0 bits (214),  Expect = 7e-17
 Identities = 56/170 (32%), Positives = 87/170 (51%), Gaps = 3/170 (1%)

Query  943   TPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK  1000
             T LL  G       R   T L  A+ +GN  ++ +LL+  G  I+    DG + L+ AA+
Sbjct  250   TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAAR  308

Query  1001  NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP  1060
             +GH   V LLL   A + A  KNG +PL  AA   H ECV+ L+ + A ++       T 
Sbjct  309   SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA  368

Query  1061  LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             L++A   G+    KLLL+   N + +  +G+TP+H A     +  ++LL+
Sbjct  369   LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLV  418


 Score = 84.7 bits (208),  Expect = 3e-16
 Identities = 53/152 (34%), Positives = 79/152 (51%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  +A +G V + S+LL E G   + + + G + L+ AAK G  D  +LLL   A  +
Sbjct  532   TPLHISAREGQVDVASVLL-EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD  590

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             +A KNG TPL  AA   + +   LL+   A+ +  A  G TPL++A K    +    LL 
Sbjct  591   SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN  650

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G   ++ T  G TP+H A   G+ D + LL+
Sbjct  651   YGAETNIVTKQGVTPLHLASQEGHTDMVTLLL  682


 Score = 84.0 bits (206),  Expect = 6e-16
 Identities = 44/132 (33%), Positives = 75/132 (56%), Gaps = 0/132 (0%)

Query  984   INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL  1043
             +N + E G + L+ AA  G+ +   LLL+  A V+   +NG TPL  A+ +G+   V+LL
Sbjct  226   VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL  285

Query  1044  ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNV  1103
             +     I+     G TPL+ A ++G+ + ++LLLE G     +T +G +P+H A    +V
Sbjct  286   LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV  345

Query  1104  DSLKLLMYHRIP  1115
             + +K L+ H+ P
Sbjct  346   ECVKHLLQHKAP  357


 Score = 81.6 bits (200),  Expect = 3e-15
 Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 38/194 (19%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--  1016
             T L  AA + ++ ++  LL E G + + + EDG + L  A + GH   V +LL  + +  
Sbjct  132   TPLYMAAQENHIDVVKYLL-ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK  190

Query  1017  -----------------------------------VNAADKNGFTPLCAAAAQGHFECVE  1041
                                                VN   ++GFTPL  AA  G+     
Sbjct  191   VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT  250

Query  1042  LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG  1101
             LL++  A ++  A  G TPL++A K GN   +KLLL+ G     KT DG TP+H A  +G
Sbjct  251   LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG  310

Query  1102  NVDSLKLLMYHRIP  1115
             +   ++LL+    P
Sbjct  311   HDQVVELLLERGAP  324


 Score = 77.0 bits (188),  Expect = 7e-14
 Identities = 56/170 (32%), Positives = 84/170 (49%), Gaps = 6/170 (3%)

Query  945   LLMSGGPAPLAGRP----TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK  1000
             LL+  G APL  R     + L  AA   +V  +  LL  +   ++    D  +AL+ AA 
Sbjct  317   LLLERG-APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PVDDVTLDYLTALHVAAH  374

Query  1001  NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP  1060
              GH    +LLL   A  NA   NGFTPL  A  +   + +ELL+ Y A+I    + G TP
Sbjct  375   CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP  434

Query  1061  LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             +++A   G+   + LLL+ G +  V    G T +H A   G V+ ++ L+
Sbjct  435   IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL  484


 Score = 73.6 bits (179),  Expect = 8e-13
 Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A+  G   ++ +LL       + +  +G++ L+ +A+ G  D   +LL A A  +
Sbjct  499   TPLHIASRLGKTEIVQLLLQHMAHP-DAATTNGYTPLHISAREGQVDVASVLLEAGAAHS  557

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
              A K GFTPL  AA  G  +  +LL+   A  + A   G TPL++A    N++   LLLE
Sbjct  558   LATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLE  617

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G +      +G+TP+H A     +     L+
Sbjct  618   KGASPHATAKNGYTPLHIAAKKNQMQIASTLL  649


 Score = 73.6 bits (179),  Expect = 8e-13
 Identities = 47/154 (30%), Positives = 82/154 (53%), Gaps = 4/154 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A+ +G+  ++++LL ++G +I+ S + G ++L+ AA+    +   +L    A  +
Sbjct  664   TPLHLASQEGHTDMVTLLL-DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD  722

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  K G+TPL  A   G+ + V  L+   AN+N     G TPL+ A + G+   I +LL+
Sbjct  723   AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ  782

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGN---VDSLKLL  1109
              G   +  T +G T +  A   G    VD+LK++
Sbjct  783   HGAKPNATTANGNTALAIAKRLGYISVVDTLKVV  816


 Score = 73.2 bits (178),  Expect = 1e-12
 Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A  +  + ++ +L+ + G  I    E G + ++ AA  GH + V LLL   A  +
Sbjct  400   TPLHIACKKNRIKVMELLV-KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD  458

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               +  G T L  AA  G  E V  L+   A ++  A   QTPL++A + G  E ++LLL+
Sbjct  459   VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ  518

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                +    TT+G+TP+H +   G VD   +L+
Sbjct  519   HMAHPDAATTNGYTPLHISAREGQVDVASVLL  550


 Score = 71.2 bits (173),  Expect = 4e-12
 Identities = 56/216 (25%), Positives = 96/216 (44%), Gaps = 5/216 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+  +  +LL++   + N    +G + L+ A K      + LL+   A + 
Sbjct  367   TALHVAAHCGHYRVTKLLLDKRA-NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ  425

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  ++G TP+  AA  GH   V LL+   A+ +     G+T L++A + G  E ++ LL 
Sbjct  426   AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR  485

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEE  1138
              G     +  +  TP+H A   G  + ++LL+ H   AH ++               G+ 
Sbjct  486   NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM--AHPDAATTNGYTPLHISAREGQV  543

Query  1139  SPEGISKPVVPADLINHANREGWTAAHIAASKGFKD  1174
                 +      A  +  A ++G+T  H+AA  G  D
Sbjct  544   DVASVLLEAGAAHSL--ATKKGFTPLHVAAKYGSLD  577


 Score = 70.1 bits (170),  Expect = 9e-12
 Identities = 35/121 (28%), Positives = 67/121 (55%), Gaps = 0/121 (0%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             D +++   AA+ G+ D V   L     +N  ++NG   L  AA +GH   V+ L+   ++
Sbjct  30    DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS  89

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             ++ A   G T L++A   G  E +K+L++ G N + ++ +G+TP++ A    ++D +K L
Sbjct  90    VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL  149

Query  1110  M  1110
             +
Sbjct  150   L  150


 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 2/104 (1%)

Query  673   HSLHSPCANTSLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAK  732
             HS  S  A T  HP ++P  +  +      +   +++   + S  +   SP S      +
Sbjct  1797  HSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTER  1856

Query  733   QLARNTVTQALSRFTSPQAGAPSRPGVPPTGDVGTHPPV--GRT  774
                 ++         SP      RP V P+G    HPPV  GRT
Sbjct  1857  HSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRT  1900


>gi|21759000|sp|Q12955|ANK3_HUMAN  Ankyrin-3 (ANK-3) (Ankyrin G)
Length=4377

 Score = 99.8 bits (247),  Expect = 1e-20
 Identities = 52/132 (39%), Positives = 82/132 (62%), Gaps = 0/132 (0%)

Query  979   EEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFE  1038
             + G+DIN   ++G +AL+ A+K GH + V  LL  EA V+AA K G T L  A+  G  E
Sbjct  62    KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE  121

Query  1039  CVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
              V++L++  AN+N  +  G TPLY+A +  + E +K LL+ G ++S+ T DG+TP+  A+
Sbjct  122   VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL  181

Query  1099  DTGNVDSLKLLM  1110
               G+   + LL+
Sbjct  182   QQGHDQVVSLLL  193


 Score = 95.9 bits (237),  Expect = 2e-19
 Identities = 56/169 (33%), Positives = 90/169 (53%), Gaps = 4/169 (2%)

Query  945   LLMSGGPAPLAGRP---TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKN  1001
             LL+  G +P A      T L  AA +  + + + LL E G D N     G ++++ AA+ 
Sbjct  616   LLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL-EYGADANAVTRQGIASVHLAAQE  674

Query  1002  GHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPL  1061
             GH D V LLL   A VN ++K+G TPL  AA +      E+L++  A+++     G TPL
Sbjct  675   GHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL  734

Query  1062  YLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             ++ C  GN + +  LL+     + KT +G+TP+H A   G+   + +L+
Sbjct  735   HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL  783


 Score = 90.5 bits (223),  Expect = 6e-18
 Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 5/216 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T +  AA  G+V ++S L++  G   N +   G +AL+ AA++G  + VR L+   AQV 
Sbjct  435   TPIHVAAFMGHVNIVSQLMHH-GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE  493

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  K+  TPL  +A  G  + V+ L+   A+ N A   G TPL+L+ + G+++    LL+
Sbjct  494   AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD  553

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEE  1138
              G + S+ T  G+TP+H A   G ++   LL+           +           D  + 
Sbjct  554   HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKV  613

Query  1139  SPEGISKPVVPADLINHANREGWTAAHIAASKGFKD  1174
             +   + +   P    + A + G+T  HIAA K   D
Sbjct  614   ALLLLDQGASP----HAAAKNGYTPLHIAAKKNQMD  645


 Score = 89.4 bits (220),  Expect = 1e-17
 Identities = 72/278 (25%), Positives = 117/278 (42%), Gaps = 63/278 (22%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A+ +GN  ++ +LL + G  I+    DG + L+  A++GH   V +LL   A + 
Sbjct  270   TPLHVASKRGNANMVKLLL-DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL  328

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYD-------------------------------  1047
             +  KNG +PL  A    H  CV+LL+ ++                               
Sbjct  329   SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD  388

Query  1048  --ANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDS  1105
               AN N  A  G TPL++ACK    + ++LLL+ G +    T  G TP+H A   G+V+ 
Sbjct  389   KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI  448

Query  1106  LKLLMYH-----------RIPAHGnsfneeesessVFDLDGG--------EESPEGISKP  1146
             +  LM+H               H  + + +         DG         +++P  IS  
Sbjct  449   VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR  508

Query  1147  VVPADLI----------NHANREGWTAAHIAASKGFKD  1174
             +  AD++          N A   G+T  H++A +G +D
Sbjct  509   LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED  546


 Score = 86.7 bits (213),  Expect = 9e-17
 Identities = 55/179 (30%), Positives = 93/179 (51%), Gaps = 30/179 (16%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  A+ +G+V ++S LL  E  +++ + + G++AL+ A+  G  + V++L++  A VNA 
Sbjct  78    LHLASKEGHVEVVSELLQREA-NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ  136

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
              +NGFTPL  AA + H E V+ L+   A+ + A + G TPL +A + G+ + + LLLE  
Sbjct  137   SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEND  196

Query  1081  T-----------------------------NRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             T                             N  V++  G+TP+H A   GN++   LL+
Sbjct  197   TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLL  255


 Score = 85.5 bits (210),  Expect = 2e-16
 Identities = 76/291 (26%), Positives = 124/291 (42%), Gaps = 18/291 (6%)

Query  892   GLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSL----------LVTASGWSPS  941
             G +  A ++S L      AF   +N VS      GAS +           +   SG +  
Sbjct  423   GASIQAVTESGLTPIHVAAFMGHVNIVS-QLMHHGASPNTTNVRGETALHMAARSGQAEV  481

Query  942   LTPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAA  999
             +  L+  G       +   T L  +A  G   ++  LL ++G   N +   G++ L+ +A
Sbjct  482   VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL-QQGASPNAATTSGYTPLHLSA  540

Query  1000  KNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQT  1059
             + GH D    LL   A ++   K GFTPL  AA  G  E   LL+   A+ + A   G T
Sbjct  541   REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT  600

Query  1060  PLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGn  1119
             PL++A    N++   LLL+ G +      +G+TP+H A     +D    L+ +   A+  
Sbjct  601   PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV  660

Query  1120  sfneeesessVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASK  1170
             +     S      L   E   + +S  +     +N +N+ G T  H+AA +
Sbjct  661   TRQGIAS----VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQE  707


 Score = 84.7 bits (208),  Expect = 3e-16
 Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 13/229 (5%)

Query  896   PACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSP----------SLTPL  945
             P  + +S   P  ++       V+A     GAS S+  T  G++P           +  L
Sbjct  525   PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI-TTKKGFTPLHVAAKYGKLEVANL  583

Query  946   LMSGGPAP-LAGRPTLLQ-QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGH  1003
             L+    +P  AG+  L     AA  +   +++LL ++G   + + ++G++ L+ AAK   
Sbjct  584   LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ  643

Query  1004  TDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL  1063
              D    LL   A  NA  + G   +  AA +GH + V LL+  +AN+N +   G TPL+L
Sbjct  644   MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHL  703

Query  1064  ACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             A +       ++L+  G +   +T  G+TP+H     GN+  +  L+ H
Sbjct  704   AAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH  752


 Score = 81.6 bits (200),  Expect = 3e-15
 Identities = 47/152 (30%), Positives = 82/152 (53%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  GN+ + ++LLN     ++++  +  + L+ A+K G+ + V+LLL   A+++
Sbjct  237   TPLHIAAHYGNINVATLLLNRAAA-VDFTARNDITPLHVASKRGNANMVKLLLDRGAKID  295

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  ++G TPL   A  GH + VE+L+   A I      G +PL++A +  +  C++LLL+
Sbjct  296   AKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ  355

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                     T D  T +H A   G+    K+L+
Sbjct  356   HNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL  387


 Score = 80.5 bits (197),  Expect = 7e-15
 Identities = 56/173 (32%), Positives = 84/173 (48%), Gaps = 7/173 (4%)

Query  945   LLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG  1002
             LL +G    LA     T L  A  QG+  ++S+LL  +        +    AL+ AA+  
Sbjct  159   LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKG-----KVRLPALHIAARKD  213

Query  1003  HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY  1062
              T    LLL  +   +   K+GFTPL  AA  G+     LL++  A ++  A    TPL+
Sbjct  214   DTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH  273

Query  1063  LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP  1115
             +A K GN   +KLLL+ G     KT DG TP+H    +G+   +++L+    P
Sbjct  274   VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP  326


 Score = 79.0 bits (193),  Expect = 2e-14
 Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 13/200 (6%)

Query  926   GASDSLLVTASGWSP----------SLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSM  975
             GAS SL  T  G++P           +  LL+          P L    AA+ + T  + 
Sbjct  163   GASQSL-ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL--HIAARKDDTKAAA  219

Query  976   LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG  1035
             LL +   + +   + G + L+ AA  G+ +   LLL+  A V+   +N  TPL  A+ +G
Sbjct  220   LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRG  279

Query  1036  HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH  1095
             +   V+LL+   A I+     G TPL+   ++G+++ +++LL+       KT +G +P+H
Sbjct  280   NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH  339

Query  1096  AAVDTGNVDSLKLLMYHRIP  1115
              A    +++ ++LL+ H +P
Sbjct  340   MATQGDHLNCVQLLLQHNVP  359


 Score = 75.9 bits (185),  Expect = 2e-13
 Identities = 46/154 (29%), Positives = 75/154 (48%), Gaps = 1/154 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A  +  + ++ +LL + G  I    E G + ++ AA  GH + V  L+   A  N
Sbjct  402   TPLHIACKKNRIKVMELLL-KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN  460

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               +  G T L  AA  G  E V  L+   A +   A   QTPL+++ + G  + ++ LL+
Sbjct  461   TTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ  520

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
              G + +  TT G+TP+H +   G+ D    L+ H
Sbjct  521   QGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH  554


 Score = 73.2 bits (178),  Expect = 1e-12
 Identities = 51/172 (29%), Positives = 87/172 (50%), Gaps = 6/172 (3%)

Query  943   TPLLMSGGPAPLAGRPTL--LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK  1000
             T LL  G  A    R  +  +  AA +G+V ++S+LL     ++N S + G + L+ AA+
Sbjct  648   TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA-NVNLSNKSGLTPLHLAAQ  706

Query  1001  NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP  1060
                 +   +L++  A V+A  K G+TPL      G+ + V  L+ + A +N     G TP
Sbjct  707   EDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP  766

Query  1061  LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGN---VDSLKLL  1109
             L+ A + G+   I +LL+   + +  T +G T +  A   G    VD+LK++
Sbjct  767   LHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIV  818


 Score = 69.3 bits (168),  Expect = 2e-11
 Identities = 34/121 (28%), Positives = 66/121 (54%), Gaps = 0/121 (0%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             D +++   AA+ GH +     +     +N  ++NG   L  A+ +GH E V  L+  +AN
Sbjct  40    DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN  99

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             ++ A   G T L++A   G  E +K+L+  G N + ++ +G+TP++ A    +++ +K L
Sbjct  100   VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL  159

Query  1110  M  1110
             +
Sbjct  160   L  160


>gi|113884|sp|P16157|ANK1_HUMAN  Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length=1881

 Score = 95.1 bits (235),  Expect = 3e-19
 Identities = 73/246 (29%), Positives = 113/246 (45%), Gaps = 8/246 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+  ++ +LL E   + N +   GH+ L+ AA+ GH + V  LL  EA   
Sbjct  472   TPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA  530

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                K GFTPL  AA  G     ELL+  DA+ N A   G TPL++A  + N + +KLLL 
Sbjct  531   CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP  590

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEE  1138
              G +      +G+TP+H A     V+  + L+ +     G++  E     +   L   E 
Sbjct  591   RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY----GGSANAESVQGVTPLHLAAQEG  646

Query  1139  SPEGISKPVVPADLINHANREGWTAAHIAASKG---FKDCNLPDALLAFSHMRVRRFYSH  1195
               E ++  +      N  N+ G T  H+ A +G     D  +   ++  +  R+     H
Sbjct  647   HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH  706

Query  1196  CSSHLG  1201
              +SH G
Sbjct  707   VASHYG  712


 Score = 94.4 bits (233),  Expect = 4e-19
 Identities = 53/152 (34%), Positives = 84/152 (55%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A+ +GNV ++ +LL + G  I    +D  + L+ AA+NGH     +LL   A + 
Sbjct  241   TPLHIASRRGNVIMVRLLL-DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ  299

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  KNG +P+  AA   H +CV LL+ YDA I+       TPL++A   G+    K+LL+
Sbjct  300   AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD  359

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G   + +  +G+TP+H A    +V  ++LL+
Sbjct  360   KGAKPNSRALNGFTPLHIACKKNHVRVMELLL  391


 Score = 92.8 bits (229),  Expect = 1e-18
 Identities = 56/152 (36%), Positives = 85/152 (55%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A+  G++ ++  LL + G   N S     + L+ AA+ GHT+  + LL  +A+VN
Sbjct  406   TPLHVASFMGHLPIVKNLL-QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVN  464

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  K+  TPL  AA  GH   V+LL+  +AN N A   G TPL++A + G+ E +  LLE
Sbjct  465   AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE  524

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                +++  T  G+TP+H A   G V   +LL+
Sbjct  525   KEASQACMTKKGFTPLHVAAKYGKVRVAELLL  556


 Score = 92.0 bits (227),  Expect = 2e-18
 Identities = 58/149 (38%), Positives = 81/149 (54%), Gaps = 3/149 (2%)

Query  955   AGRPTLLQQAAAQGNVT-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA  1013
             A   T   +AA  GN+   L  L N  G+DIN   ++G + L+ A+K GH   V  LL  
Sbjct  10    ADAATSFLRAARSGNLDKALDHLRN--GVDINTCNQNGLNGLHLASKEGHVKMVVELLHK  67

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
             E  +    K G T L  AA  G  E V  L++Y AN+N  +  G TPLY+A +  + E +
Sbjct  68    EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV  127

Query  1074  KLLLEAGTNRSVKTTDGWTPVHAAVDTGN  1102
             K LLE G N++V T DG+TP+  A+  G+
Sbjct  128   KFLLENGANQNVATEDGFTPLAVALQQGH  156


 Score = 92.0 bits (227),  Expect = 2e-18
 Identities = 77/261 (29%), Positives = 119/261 (45%), Gaps = 11/261 (4%)

Query  913   SSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP--TLLQQAAAQGNV  970
             +SI+ V+ S   P    S +    G  P +  LL  G    ++     T L  AA  G+ 
Sbjct  395   ASIDAVTESGLTPLHVASFM----GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT  450

Query  971   TLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCA  1030
              +   LL  +   +N   +D  + L+ AA+ GHT+ V+LLL   A  N A   G TPL  
Sbjct  451   EVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI  509

Query  1031  AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG  1090
             AA +GH E V  L+  +A+       G TPL++A K G     +LLLE   + +    +G
Sbjct  510   AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG  569

Query  1091  WTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPA  1150
              TP+H AV   N+D +KLL    +P  G+  +   +  +   +   +   E     +   
Sbjct  570   LTPLHVAVHHNNLDIVKLL----LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYG  625

Query  1151  DLINHANREGWTAAHIAASKG  1171
                N  + +G T  H+AA +G
Sbjct  626   GSANAESVQGVTPLHLAAQEG  646


 Score = 90.9 bits (224),  Expect = 5e-18
 Identities = 54/152 (35%), Positives = 83/152 (54%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+V +  +LL + G  I    ++G S ++ AA+  H DCVRLLL  +A+++
Sbjct  274   TPLHCAARNGHVRISEILL-DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID  332

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                 +  TPL  AA  GH    ++L+   A  N  A  G TPL++ACK  +   ++LLL+
Sbjct  333   DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK  392

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G +    T  G TP+H A   G++  +K L+
Sbjct  393   TGASIDAVTESGLTPLHVASFMGHLPIVKNLL  424


 Score = 89.4 bits (220),  Expect = 1e-17
 Identities = 58/168 (34%), Positives = 86/168 (51%), Gaps = 3/168 (1%)

Query  945   LLMSGGP--APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG  1002
             LL  GG   +P     T L  AA Q  V +   LL   G   N     G + L+ AA+ G
Sbjct  588   LLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEG  646

Query  1003  HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY  1062
             H + V LLLS +A  N  +K+G TPL   A +GH    ++LI +   ++     G TPL+
Sbjct  647   HAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLH  706

Query  1063  LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             +A   GN + +K LL+   + + KT  G++P+H A   G+ D + LL+
Sbjct  707   VASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL  754


 Score = 85.1 bits (209),  Expect = 3e-16
 Identities = 49/152 (32%), Positives = 81/152 (53%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA   N+ +  +LLN  G  +N++ ++G + L+ A++ G+   VRLLL   AQ+ 
Sbjct  208   TPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE  266

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                K+  TPL  AA  GH    E+L+ + A I      G +P+++A +  + +C++LLL+
Sbjct  267   TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ  326

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                     T D  TP+H A   G+    K+L+
Sbjct  327   YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL  358


 Score = 84.3 bits (207),  Expect = 5e-16
 Identities = 53/152 (34%), Positives = 81/152 (53%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A  + +V ++ +LL + G  I+   E G + L+ A+  GH   V+ LL   A  N
Sbjct  373   TPLHIACKKNHVRVMELLL-KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN  431

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
              ++    TPL  AA  GH E  + L+   A +N  A   QTPL+ A + G+   +KLLLE
Sbjct  432   VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE  491

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                N ++ TT G TP+H A   G+V+++  L+
Sbjct  492   NNANPNLATTAGHTPLHIAAREGHVETVLALL  523


 Score = 84.0 bits (206),  Expect = 6e-16
 Identities = 52/155 (33%), Positives = 76/155 (49%), Gaps = 1/155 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A    N+ ++ +LL   G   +    +G++ L+ AAK    +  R LL      N
Sbjct  571   TPLHVAVHHNNLDIVKLLLPRGGSP-HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN  629

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A    G TPL  AA +GH E V LL+S  AN N     G TPL+L  + G+     +L++
Sbjct  630   AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK  689

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
              G      T  G+TP+H A   GN+  +K L+ H+
Sbjct  690   HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ  724


 Score = 80.9 bits (198),  Expect = 5e-15
 Identities = 55/186 (29%), Positives = 85/186 (45%), Gaps = 30/186 (16%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHS-------------------------  993
             T L  AA + ++ ++  LL E G + N + EDG +                         
Sbjct  113   TPLYMAAQENHLEVVKFLL-ENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK  171

Query  994   ----ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
                 AL+ AA+N  T    +LL  +   +   K GFTPL  AA   +    +LL++  A+
Sbjct  172   VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS  231

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             +N     G TPL++A + GN   ++LLL+ G     KT D  TP+H A   G+V   ++L
Sbjct  232   VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL  291

Query  1110  MYHRIP  1115
             + H  P
Sbjct  292   LDHGAP  297


 Score = 77.8 bits (190),  Expect = 4e-14
 Identities = 54/179 (30%), Positives = 89/179 (49%), Gaps = 30/179 (16%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  A+ +G+V ++  LL++E + +  + + G++AL+ AA  G  + VR L++  A VNA 
Sbjct  49    LHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQ  107

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
              + GFTPL  AA + H E V+ L+   AN N A + G TPL +A + G++  +  L+  G
Sbjct  108   SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG  167

Query  1081  T-----------------------------NRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             T                             N  V +  G+TP+H A    N++  +LL+
Sbjct  168   TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL  226


 Score = 77.4 bits (189),  Expect = 6e-14
 Identities = 49/152 (32%), Positives = 79/152 (51%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+  +  +LL ++G   N    +G + L+ A K  H   + LLL   A ++
Sbjct  340   TPLHVAAHCGHHRVAKVLL-DKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID  398

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  ++G TPL  A+  GH   V+ L+   A+ N +    +TPL++A + G+ E  K LL+
Sbjct  399   AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ  458

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                  + K  D  TP+H A   G+ + +KLL+
Sbjct  459   NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLL  490


 Score = 74.3 bits (181),  Expect = 5e-13
 Identities = 42/151 (27%), Positives = 83/151 (54%), Gaps = 1/151 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA +G+  ++++LL+++  + N   + G + L+  A+ GH     +L+     V+
Sbjct  637   TPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD  695

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A  + G+TPL  A+  G+ + V+ L+ + A++N     G +PL+ A + G+ + + LLL+
Sbjct  696   ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK  755

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
              G + +  ++DG TP+  A   G +    +L
Sbjct  756   NGASPNEVSSDGTTPLAIAKRLGYISVTDVL  786


 Score = 72.8 bits (177),  Expect = 1e-12
 Identities = 44/148 (29%), Positives = 78/148 (52%), Gaps = 0/148 (0%)

Query  965   AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG  1024
             AA+ + T  + +L +   + +   + G + L+ AA   + +  +LLL+  A VN   +NG
Sbjct  180   AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG  239

Query  1025  FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS  1084
              TPL  A+ +G+   V LL+   A I        TPL+ A +NG+    ++LL+ G    
Sbjct  240   ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ  299

Query  1085  VKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
              KT +G +P+H A    ++D ++LL+ +
Sbjct  300   AKTKNGLSPIHMAAQGDHLDCVRLLLQY  327


 Score = 55.1 bits (131),  Expect = 3e-07
 Identities = 30/121 (24%), Positives = 60/121 (49%), Gaps = 0/121 (0%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             D  ++   AA++G+ D     L     +N  ++NG   L  A+ +GH + V  L+  +  
Sbjct  11    DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII  70

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             +      G T L++A   G  E ++ L+  G N + ++  G+TP++ A    +++ +K L
Sbjct  71    LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL  130

Query  1110  M  1110
             +
Sbjct  131   L  131


>gi|90109864|sp|Q9ULJ7|ANR50_HUMAN  Ankyrin repeat domain-containing protein 50
Length=1375

 Score = 94.7 bits (234),  Expect = 3e-19
 Identities = 50/138 (36%), Positives = 81/138 (58%), Gaps = 1/138 (0%)

Query  965   AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG  1024
             A++G+ +++S+L+ + G ++++  +DG + L  AA  GH D V LLL   A V+  D NG
Sbjct  669   ASKGHASVVSLLI-DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG  727

Query  1025  FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS  1084
              TPL AAA+ GH   V  L+ + A ++     G+T L +A   GN E ++ LL+ G + +
Sbjct  728   RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN  787

Query  1085  VKTTDGWTPVHAAVDTGN  1102
              +   GWTP+H A   G+
Sbjct  788   HRDDAGWTPLHMAAFEGH  805


 Score = 86.7 bits (213),  Expect = 9e-17
 Identities = 65/220 (29%), Positives = 99/220 (45%), Gaps = 43/220 (19%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAA-----KNGHTDCVRLLLSA  1013
             T L  AA  G+  ++  LL + G ++N+   DG +AL  AA       GH   V LL+  
Sbjct  625   TALIAAAYMGHREIVEHLL-DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR  683

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
              A+V+  DK+G TPL  AA +GH + V+LL+   A+++H  + G+TPL  A   G+   +
Sbjct  684   GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV  743

Query  1074  KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDL  1133
               LL  G       ++G T +  A   GNV+ ++ L                       L
Sbjct  744   NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL-----------------------L  780

Query  1134  DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFK  1173
             D G +               NH +  GWT  H+AA +G +
Sbjct  781   DRGLDE--------------NHRDDAGWTPLHMAAFEGHR  806


 Score = 85.5 bits (210),  Expect = 2e-16
 Identities = 52/155 (33%), Positives = 84/155 (54%), Gaps = 1/155 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA +G+V ++ +LL E G D++++  +G + L +AA  GH   V  LL   A V+
Sbjct  696   TPLLVAAYEGHVDVVDLLL-EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVD  754

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             + D  G T L  A+AQG+ E V  L+    + NH  D G TPL++A   G++   + L+E
Sbjct  755   SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE  814

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
              G   +    DG  P   A   G+ D +++L+ ++
Sbjct  815   QGARTNEIDNDGRIPFILASQEGHYDCVQILLENK  849


 Score = 85.1 bits (209),  Expect = 3e-16
 Identities = 52/154 (33%), Positives = 86/154 (55%), Gaps = 2/154 (1%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA  1015
             GRPTL    A +  +T+    L E G ++  S  +G +AL+ +   GH + V++L++  A
Sbjct  892   GRPTLYI-LALENQLTMAEYFL-ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA  949

Query  1016  QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL  1075
              VNAAD    + L +AA QGH + V+LLI + A ++H  + G T L +A + G+ + +++
Sbjct  950   DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQV  1009

Query  1076  LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             LLE G + +     G T +  A   G+   +KLL
Sbjct  1010  LLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL  1043


 Score = 82.4 bits (202),  Expect = 2e-15
 Identities = 54/164 (32%), Positives = 86/164 (52%), Gaps = 6/164 (3%)

Query  931   LLVTASGWSPSLTPLLMSGGPA----PLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINY  986
             LL  AS    S+   L+  G A       GR T+L  A+AQGNV ++  LL + GLD N+
Sbjct  731   LLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIASAQGNVEVVRTLL-DRGLDENH  788

Query  987   SCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISY  1046
               + G + L+ AA  GH      L+   A+ N  D +G  P   A+ +GH++CV++L+  
Sbjct  789   RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN  848

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG  1090
              +NI+     G+  L +A   G+++ ++LL   G + + K  DG
Sbjct  849   KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADG  892


 Score = 82.0 bits (201),  Expect = 2e-15
 Identities = 65/186 (34%), Positives = 96/186 (51%), Gaps = 6/186 (3%)

Query  916   NPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPL----AGRPTLLQQAAAQGNVT  971
             N  S + C       L   A   S  +  LL+S G A L    A   T L  AA QG+  
Sbjct  480   NGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRG-ADLEIEDAHGHTPLTLAARQGHTK  538

Query  972   LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAA  1031
             +++ L+   G +IN++ +DG +AL SAA  GHT+ V  LL A  +V+ AD +  T L AA
Sbjct  539   VVNCLIGC-GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA  597

Query  1032  AAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW  1091
             A  GH + V  L+ + A +N A + G+T L  A   G++E ++ LL+ G   + +  DG 
Sbjct  598   AWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGR  657

Query  1092  TPVHAA  1097
             T +  A
Sbjct  658   TALSVA  663


 Score = 80.1 bits (196),  Expect = 9e-15
 Identities = 50/136 (36%), Positives = 66/136 (48%), Gaps = 0/136 (0%)

Query  977   LNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGH  1036
             L + G  +N    +G + L +AA +G  D V LL+S  A +   D +G TPL  AA QGH
Sbjct  477   LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH  536

Query  1037  FECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHA  1096
              + V  LI   ANINH    G T L  A   G+ E +  LL AG        D  T + A
Sbjct  537   TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA  596

Query  1097  AVDTGNVDSLKLLMYH  1112
             A   G+ D +  L+ H
Sbjct  597   AAWGGHEDIVLNLLQH  612


 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 65/225 (28%), Positives = 103/225 (45%), Gaps = 11/225 (4%)

Query  897   ACSDSSLVIPTTIAFCSSINPV-----SASSCRPGASDSLLVTASGWSPSLTPLLMSGGP  951
             A S ++L +P +    S ++ +         C       LLV A      +  LL+ GG 
Sbjct  659   ALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA  718

Query  952   ----APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCV  1007
                     GR  LL  AA+ G+ ++++ LL   G  ++    +G + L  A+  G+ + V
Sbjct  719   DVDHTDNNGRTPLLA-AASMGHASVVNTLLFW-GAAVDSIDSEGRTVLSIASAQGNVEVV  776

Query  1008  RLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKN  1067
             R LL      N  D  G+TPL  AA +GH    E LI   A  N   + G+ P  LA + 
Sbjct  777   RTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE  836

Query  1068  GNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             G+ +C+++LLE  +N   +  DG   +  A   G+ D ++LL  H
Sbjct  837   GHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH  881


 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 45/124 (36%), Positives = 72/124 (58%), Gaps = 1/124 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  +  QG++ ++ +L+     D+N +  +  SAL SAA  GH   V+LL+   A V+
Sbjct  927   TALHVSCWQGHMEMVQVLIAYHA-DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD  985

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                  G T LC AA +GH + V++L+ + A+ NHA   G+T + +A KNG+ + IKLL +
Sbjct  986   HTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK  1045

Query  1079  AGTN  1082
              G +
Sbjct  1046  YGAS  1049


 Score = 76.6 bits (187),  Expect = 9e-14
 Identities = 56/217 (25%), Positives = 103/217 (47%), Gaps = 2/217 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             TLL  AA  G++ ++++L++  G D+      GH+ L  AA+ GHT  V  L+   A +N
Sbjct  493   TLLANAAYSGSLDVVNLLVSR-GADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN  551

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D++G+T L +AA  GH E V  L+     ++ A    +T L  A   G+++ +  LL+
Sbjct  552   HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQ  611

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA-HGnsfneeesessVFDLDGGE  1137
              G   +    +G T + AA   G+ + ++ L+ H     H +         +   +   +
Sbjct  612   HGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASK  671

Query  1138  ESPEGISKPVVPADLINHANREGWTAAHIAASKGFKD  1174
                  +S  +     ++H +++G T   +AA +G  D
Sbjct  672   GHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD  708


 Score = 76.3 bits (186),  Expect = 1e-13
 Identities = 56/216 (25%), Positives = 99/216 (45%), Gaps = 5/216 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA +G+  +   L+ E+G   N    DG      A++ GH DCV++LL  ++ ++
Sbjct  795   TPLHMAAFEGHRLICEALI-EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID  853

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                 +G   L  AA +GH + VELL S+ A++N     G+  LY+          +  LE
Sbjct  854   QRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLE  913

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEE  1138
              G N      +G T +H +   G+++ +++L    I  H +    +  + S       + 
Sbjct  914   NGANVEASDAEGRTALHVSCWQGHMEMVQVL----IAYHADVNAADNEKRSALQSAAWQG  969

Query  1139  SPEGISKPVVPADLINHANREGWTAAHIAASKGFKD  1174
               + +   +    +++H   +G TA  IAA +G  D
Sbjct  970   HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHID  1005


 Score = 73.9 bits (180),  Expect = 6e-13
 Identities = 46/152 (30%), Positives = 76/152 (50%), Gaps = 1/152 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L+ AA +G+  ++ +L +  G D+N    DG   LY  A           L   A V A+
Sbjct  863   LRVAALEGHRDIVELLFSH-GADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEAS  921

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D  G T L  +  QGH E V++LI+Y A++N A +  ++ L  A   G+ + ++LL+E G
Sbjct  922   DAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHG  981

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                      G T +  A   G++D +++L+ H
Sbjct  982   AVVDHTCNQGATALCIAAQEGHIDVVQVLLEH  1013


 Score = 69.7 bits (169),  Expect = 1e-11
 Identities = 44/136 (32%), Positives = 65/136 (47%), Gaps = 2/136 (1%)

Query  976   LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG  1035
             LL + G  +N   ED  ++          D +R LL   A VN  D NG T L  AA  G
Sbjct  445   LLVKAGAHVN--SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSG  502

Query  1036  HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH  1095
               + V LL+S  A++      G TPL LA + G+ + +  L+  G N +    DGWT + 
Sbjct  503   SLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALR  562

Query  1096  AAVDTGNVDSLKLLMY  1111
             +A   G+ + +  L+Y
Sbjct  563   SAAWGGHTEVVSALLY  578


 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 26/106 (24%), Positives = 49/106 (46%), Gaps = 2/106 (1%)

Query  1005  DCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLA  1064
             + ++LL+ A A VN+ D    T      A    + +  L+   A++N     G+T L  A
Sbjct  441   EVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA  498

Query  1065  CKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
               +G+ + + LL+  G +  ++   G TP+  A   G+   +  L+
Sbjct  499   AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI  544


>gi|57015280|sp|O15084|ANR28_HUMAN  Ankyrin repeat domain-containing protein 28
Length=1086

 Score = 93.2 bits (230),  Expect = 1e-18
 Identities = 61/171 (35%), Positives = 93/171 (54%), Gaps = 3/171 (1%)

Query  941   SLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK  1000
             +L PLL +   +  AGR T L  AA  G+  ++ +LL+  G +IN   +    A++ AA 
Sbjct  158   ALVPLLSNVNVSDRAGR-TALHHAAFSGHGEMVKLLLSR-GANINAFDKKDRRAIHWAAY  215

Query  1001  NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTP  1060
              GH + V+LL+S  A+V   DK  +TPL AAA+ G    V+ L+    ++N     G TP
Sbjct  216   MGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTP  275

Query  1061  LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH-AAVDTGNVDSLKLLM  1110
             L++AC NG    +  L++ G   + K   G+TP+H AA  T     L+LL+
Sbjct  276   LHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLV  326


 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 0/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AAA  +  L   LL   G D+N   +DG + L+  A +G     + ++ + A ++
Sbjct  307   TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID  366

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               DKNG TPL  AA  GH   +  LI+  A+       G  PL+LA  +G  +C + LL 
Sbjct  367   CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS  426

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             +G +       G T +HAA   GN++ L LL+
Sbjct  427   SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL  458


 Score = 77.4 bits (189),  Expect = 6e-14
 Identities = 81/292 (27%), Positives = 125/292 (42%), Gaps = 46/292 (15%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  +   G+   +  LLN+ G +++   + G +AL+  A  GH +CV  LL   A+  
Sbjct  688   TPLMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCL  746

Query  1019  AADKNGFTPLCAAAAQGHFECVELLI----SYDANINHAADGGQTPLYLACKNGNKECIK  1074
               D  G TP+  +AA GH   +  L+    S DAN   A + G T L+ AC NG++ C++
Sbjct  747   LRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVE  806

Query  1075  LLLEAGTNRS--------------------------------VKTTD--GWTPVHAAVDT  1100
             LLLE    +                                 V  TD  G TP+HAA  T
Sbjct  807   LLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT  866

Query  1101  GNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPADLINHANREG  1160
              +V+ L+LL+ H   A  NS +       +   + G+ +   +      A+L    N + 
Sbjct  867   DHVECLQLLLSHN--AQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKN  924

Query  1161  WTAAHIAASKGFKDCNLPDALLAFSHMRVRRFYSHCSSHLGPPGGIHELSGL  1212
              TA H+A SKG +      ALL    +  R   +  ++ L  P  +   +GL
Sbjct  925   -TALHLACSKGHE----TSALLILEKITDRNLINATNAALQTPLHVAARNGL  971


 Score = 75.9 bits (185),  Expect = 2e-13
 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 1/154 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+  ++ +L+   G  +N       + L+ A  +   + V++LL   A VN
Sbjct  76    TPLHAAAYLGDAEIIELLILS-GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN  134

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A DKN  TPL  AAA    +C E L+   +N+N +   G+T L+ A  +G+ E +KLLL 
Sbjct  135   ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS  194

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
              G N +         +H A   G+++ +KLL+ H
Sbjct  195   RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH  228


 Score = 75.9 bits (185),  Expect = 2e-13
 Identities = 61/222 (27%), Positives = 100/222 (45%), Gaps = 27/222 (12%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L +A A  +   + +LL     D+N   ++  + L+ AA N    C   L+   + VN
Sbjct  109   TPLHRAVASCSEEAVQVLLKHSA-DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN  167

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
              +D+ G T L  AA  GH E V+LL+S  ANIN      +  ++ A   G+ E +KLL+ 
Sbjct  168   VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS  227

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM-----------YHRIPAHGnsfneeese  1127
              G   + K    +TP+HAA  +G +  +K L+           Y   P H          
Sbjct  228   HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH----------  277

Query  1128  ssVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAAS  1169
               V   +G +     +++ +    ++N  N +G+T  H AA+
Sbjct  278   --VACYNGQDVV---VNELIDCGAIVNQKNEKGFTPLHFAAA  314


 Score = 73.9 bits (180),  Expect = 6e-13
 Identities = 41/128 (32%), Positives = 71/128 (55%), Gaps = 0/128 (0%)

Query  983   DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVEL  1042
             D+N+   +  + L++AA  G  + + LL+ + A+VNA D    TPL  A A    E V++
Sbjct  66    DVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQV  125

Query  1043  LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGN  1102
             L+ + A++N      QTPL++A  N   +C + L+   +N +V    G T +H A  +G+
Sbjct  126   LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH  185

Query  1103  VDSLKLLM  1110
              + +KLL+
Sbjct  186   GEMVKLLL  193


 Score = 73.9 bits (180),  Expect = 6e-13
 Identities = 54/153 (35%), Positives = 80/153 (52%), Gaps = 3/153 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+  L++ L+   G D       G   L+ AA +G +DC R LLS+   ++
Sbjct  374   TPLHIAARYGHELLINTLITS-GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDID  432

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D  G T L AAAA G+ EC+ LL++  A+ N     G++PL+ A  N N +C+  L+ 
Sbjct  433   TPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVG  492

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY  1111
             +G + +     G TP+H A  T + D  K L Y
Sbjct  493   SGASVNDLDERGCTPLHYAA-TSDTDG-KCLEY  523


 Score = 72.4 bits (176),  Expect = 2e-12
 Identities = 69/248 (27%), Positives = 107/248 (43%), Gaps = 31/248 (12%)

Query  932   LVTASGWSPSLTPLLMSGGPAPLA---GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSC  988
             L   SG+S     LL SG         GR T L  AAA GN+  L++LLN  G D N   
Sbjct  411   LAALSGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAGGNLECLNLLLNT-GADFNKKD  468

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPL-CAAAAQGHFECVELLISYD  1047
             + G S L+ AA N +  C+  L+ + A VN  D+ G TPL  AA +    +C+E L+  D
Sbjct  469   KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND  528

Query  1048  ANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLK  1107
             AN       G   ++ +   G++ C++L+        +  T G   +  + +   +  L 
Sbjct  529   ANPGVRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLH  588

Query  1108  LLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIA  1167
             L  YH                      G  ++ E + + ++  D+ N + R   T   +A
Sbjct  589   LAAYH----------------------GHHQALEVLVQSLLDLDVRNSSGR---TPLDLA  623

Query  1168  ASKGFKDC  1175
             A KG  +C
Sbjct  624   AFKGHVEC  631


 Score = 69.3 bits (168),  Expect = 2e-11
 Identities = 73/270 (27%), Positives = 108/270 (40%), Gaps = 64/270 (23%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGH--SALYSAAKNGHTDCVRLLLSA  1013
             G    LQ  A++   T L +L+   G D+    ++    S L+ AA +GH   + +L+ +
Sbjct  549   GHRLCLQLIASE---TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS  605

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI-----------NHAA--------  1054
                ++  + +G TPL  AA +GH ECV++LI+  A+I            HAA        
Sbjct  606   LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC  665

Query  1055  -----------------DG-GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHA  1096
                              DG GQTPL L+  NG+ +C+  LL  G N   K   G T +H 
Sbjct  666   LRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHR  725

Query  1097  AVDTGNVDSLKLLMYH-----------RIPAHGnsfneeesessVFDLDGGEESPEGISK  1145
                TG+ + +  L+ H           R P H ++               G       S 
Sbjct  726   GAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL-------GALLQSAASM  778

Query  1146  PVVPADLINHANREGWTAAHIAASKGFKDC  1175
                PA   NH    G+TA H A   G + C
Sbjct  779   DANPATADNH----GYTALHWACYNGHETC  804


 Score = 66.6 bits (161),  Expect = 1e-10
 Identities = 56/194 (28%), Positives = 83/194 (42%), Gaps = 39/194 (20%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDI-NYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             L  A    N     ML++  G  I N +   G + L++AA   H +C++LLLS  AQVN+
Sbjct  825   LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS  884

Query  1020  ADKNGFTPLCAAAAQGHFECVELLISY---------------------------------  1046
              D  G TPL  AA  G    VE+L+S                                  
Sbjct  885   VDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILE  944

Query  1047  ---DANINHAADGG-QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGN  1102
                D N+ +A +   QTPL++A +NG    ++ LL  G +      +G+TP  A     +
Sbjct  945   KITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKD  1004

Query  1103  V-DSLKLLMYHRIP  1115
             V D L L++   +P
Sbjct  1005  VADCLALILATMMP  1018


 Score = 57.0 bits (136),  Expect = 8e-08
 Identities = 36/106 (33%), Positives = 55/106 (51%), Gaps = 0/106 (0%)

Query  992   HSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANIN  1051
             + +L  A  NG  D VR L+  +  VN  D    TPL AAA  G  E +ELLI   A +N
Sbjct  42    YPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN  101

Query  1052  HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
                    TPL+ A  + ++E +++LL+   + + +  +  TP+H A
Sbjct  102   AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA  147


 Score = 44.7 bits (104),  Expect = 4e-04
 Identities = 47/175 (26%), Positives = 81/175 (46%), Gaps = 19/175 (10%)

Query  879   ATSQVGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGW  938
             AT   G  P     L+  A +D    +   ++  + +N V ++   P     L++ A   
Sbjct  851   ATDSKGRTP-----LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTP-----LMMAAENG  900

Query  939   SPSLTPLLMSGGPAPLA----GRPTLLQQAAAQGNVTLLSMLLNEEGLD---INYSCEDG  991
               +   +L+S   A L      + T L  A ++G+ T  ++L+ E+  D   IN +    
Sbjct  901   QTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETS-ALLILEKITDRNLINATNAAL  959

Query  992   HSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHF-ECVELLIS  1045
              + L+ AA+NG T  V+ LL   A V A D+NG+TP  A A      +C+ L+++
Sbjct  960   QTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILA  1014


 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 36/147 (24%), Positives = 67/147 (45%), Gaps = 4/147 (2%)

Query  1025  FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS  1084
             +  L  A   G  + V  LI    ++N   +  +TPL+ A   G+ E I+LL+ +G   +
Sbjct  42    YPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN  101

Query  1085  VKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGIS  1144
              K +   TP+H AV + + +++++L+ H    +    N +        +    ++ +   
Sbjct  102   AKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTP----LHIAAANKAVKCAE  157

Query  1145  KPVVPADLINHANREGWTAAHIAASKG  1171
               V     +N ++R G TA H AA  G
Sbjct  158   ALVPLLSNVNVSDRAGRTALHHAAFSG  184


>gi|29839756|sp|Q96DX5|ASB9_HUMAN  Ankyrin repeat and SOCS box protein 9 (ASB-9)
Length=294

 Score = 92.8 bits (229),  Expect = 1e-18
 Identities = 66/189 (34%), Positives = 97/189 (51%), Gaps = 18/189 (9%)

Query  936   SGWSP-----------SLTPLLMSGGPAPL--AGRPTLLQQAAAQGNVTLLSMLLNEEGL  982
             S WSP           SL  L+  G    +  A   + L +A   G+++ + +LL + G 
Sbjct  35    SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILL-KHGA  93

Query  983   DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVEL  1042
              +N    D H+ L++A  +G  DCV LLL   A V   + +  +P+  AA +GH ECV  
Sbjct  94    QVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQP-ESDLASPIHEAARRGHVECVNS  152

Query  1043  LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN-RSVKTTDGWTPVHAAVDTG  1101
             LI+Y  NI+H      TPLYLAC+N  + C+K LLE+G +    K  D  +P+HA   T 
Sbjct  153   LIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD--SPLHAVARTA  210

Query  1102  NVDSLKLLM  1110
             + +   LLM
Sbjct  211   SEELACLLM  219


 Score = 50.4 bits (119),  Expect = 7e-06
 Identities = 29/88 (32%), Positives = 46/88 (52%), Gaps = 0/88 (0%)

Query  1025  FTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS  1084
             ++P+  AA  GH   +  LIS    +N       +PL+ AC  G+  C+K+LL+ G   +
Sbjct  37    WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN  96

Query  1085  VKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
               T D  TP+  A  +G+ D + LL+ H
Sbjct  97    GVTADWHTPLFNACVSGSWDCVNLLLQH  124


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 15/60 (25%), Positives = 34/60 (56%), Gaps = 0/60 (0%)

Query  1059  TPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHG  1118
             +P++ A  +G++  ++ L+  G   ++ T D  +P+H A   G++  +K+L+ H    +G
Sbjct  38    SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG  97


>gi|20531999|sp|Q96Q27|ASB2_HUMAN  Ankyrin repeat and SOCS box protein 2 (ASB-2)
Length=587

 Score = 92.8 bits (229),  Expect = 1e-18
 Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 3/181 (1%)

Query  932   LVTASGWSPSLTPLLMSGGPAPLAG--RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCE  989
             L T  G    L  LL +G    ++   R T L +A  + N   + +L+ +   D N+ C 
Sbjct  130   LATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV-QHNADTNHRCN  188

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
              G +AL+ +      + +++L+S  A+V + +  G TPL  AA  G  E +  L  Y A+
Sbjct  189   RGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGAD  248

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             IN  A    + LY ACKN ++E ++ LL  G + +    DG  P+H A   GN   +++L
Sbjct  249   INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQML  308

Query  1110  M  1110
             +
Sbjct  309   L  309


 Score = 75.9 bits (185),  Expect = 2e-13
 Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 4/211 (1%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G V  L +L       I+       +A+Y A   GH DC+  LL A A+ + +
Sbjct  94    LHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDIS  153

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             +K+  TPL  A  + + E V++L+ ++A+ NH  + G T L+ +    + E +++L+  G
Sbjct  154   NKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGG  213

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESP  1140
                  K   G TP+  A  +G +++L+ L  +    +  + +   +           E  
Sbjct  214   AKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACK----NEHE  269

Query  1141  EGISKPVVPADLINHANREGWTAAHIAASKG  1171
             E +   +      N  N++G    HIA+ KG
Sbjct  270   EVVEFLLSQGADANKTNKDGLLPLHIASKKG  300


 Score = 63.2 bits (152),  Expect = 1e-09
 Identities = 37/151 (24%), Positives = 77/151 (50%), Gaps = 2/151 (1%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA-EAQVNA  1019
             L +A   G+   L  ++ +EG ++    ++G   L+ AA  G   C+++L  A    ++ 
Sbjct  61    LIKAIKDGDEEALKTMI-KEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ  119

Query  1020  ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA  1079
                   T +  A  +GH +C+  L+   A  + +    +TPLY AC+  N E +K+L++ 
Sbjct  120   RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH  179

Query  1080  GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
               + + +   GWT +H +V   +++ +++L+
Sbjct  180   NADTNHRCNRGWTALHESVSRNDLEVMQILV  210


 Score = 58.5 bits (140),  Expect = 3e-08
 Identities = 32/119 (26%), Positives = 61/119 (51%), Gaps = 1/119 (0%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLI-SYDANINHA  1053
             L  A K+G  + ++ ++     +   +K G+ PL  AA  G   C+++L  +Y   I+  
Sbjct  61    LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR  120

Query  1054  ADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                 +T +YLA   G+ +C+  LL+AG    +      TP++ A +  N +++K+L+ H
Sbjct  121   TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH  179


 Score = 46.6 bits (109),  Expect = 1e-04
 Identities = 56/212 (26%), Positives = 78/212 (36%), Gaps = 75/212 (35%)

Query  945   LLMSGGP---APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKN  1001
             +L+SGG    +  A   T L  AA  G +  L  L  + G DIN    D  SALY A KN
Sbjct  208   ILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA-KYGADINTQASDNASALYEACKN  266

Query  1002  GHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG--------------------------  1035
              H + V  LLS  A  N  +K+G  PL  A+ +G                          
Sbjct  267   EHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLH  326

Query  1036  ------HFECVELLIS--YDAN----------------------------------INHA  1053
                   H E +E L+S  +D N                                  + H 
Sbjct  327   LAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG  386

Query  1054  ADGGQ---TPLYLACKNGNKECIKLLLEAGTN  1082
             AD  +   +PL +A ++G    ++LLL+ G N
Sbjct  387   ADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN  418


 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 0/50 (0%)

Query  1060  PLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             PL  A K+G++E +K +++ G N +    +GW P+H A   G V  LK+L
Sbjct  60    PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL  109


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 38/146 (26%), Positives = 57/146 (39%), Gaps = 7/146 (4%)

Query  1027  PLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA--GTNRS  1084
             PL  A   G  E ++ +I    N+      G  PL+ A   G   C+K+L  A  GT   
Sbjct  60    PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGT-ID  118

Query  1085  VKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGIS  1144
              +T    T V+ A   G++D L  L    + A        +S  +        ++ E + 
Sbjct  119   QRTLQEETAVYLATCRGHLDCLLSL----LQAGAEPDISNKSRETPLYKACERKNAEAVK  174

Query  1145  KPVVPADLINHANREGWTAAHIAASK  1170
               V      NH    GWTA H + S+
Sbjct  175   ILVQHNADTNHRCNRGWTALHESVSR  200


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 3/59 (5%)

Query  993   SALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANIN  1051
             SALY A  N +     LLL   A  N   ++  +PL  A   G    ++LL+ + ANI+
Sbjct  365   SALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANID  420


>gi|68565512|sp|Q86YT6|MIB1_HUMAN  Ubiquitin ligase protein MIB1 (Mind bomb homolog 1) (DAPK-interacting 
protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin 
repeat domain protein 2)
Length=1006

 Score = 90.5 bits (223),  Expect = 6e-18
 Identities = 52/150 (34%), Positives = 85/150 (56%), Gaps = 1/150 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AAA G+V  +  LL    +D+N  C  GH+A+ +A++NGH D ++LLL     V A 
Sbjct  435   LVKAAANGDVAKVEDLLKRPDVDVNGQCA-GHTAMQAASQNGHVDILKLLLKQNVDVEAE  493

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             DK+G   +  AA       +E+L    A++N      QTPL++A   G+ + +K LL+ G
Sbjct  494   DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG  553

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              + S++ ++G TP+H A+     D L +L+
Sbjct  554   CHPSLQDSEGDTPLHDAISKKRDDILAVLL  583


 Score = 71.2 bits (173),  Expect = 4e-12
 Identities = 49/155 (31%), Positives = 83/155 (53%), Gaps = 5/155 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ--  1016
             T L  A ++    +L++LL E G D+  +  +G +AL+ AA  G+   +R+LLS   +  
Sbjct  565   TPLHDAISKKRDDILAVLL-EAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPW  623

Query  1017  -VNAADKNGFTPLCAAAAQGHFECVELLISY-DANINHAADGGQTPLYLACKNGNKECIK  1074
              V+    +G+T L  AA   H E  ELL+   +AN++      QT L+LA +  + + ++
Sbjct  624   IVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVR  683

Query  1075  LLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             LL+ AG    ++  DG TP+H A+    +  L+ L
Sbjct  684   LLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQL  718


>gi|61213006|sp|Q8WXE0|CSKI2_HUMAN  Caskin-2
Length=1202

 Score = 90.1 bits (222),  Expect = 8e-18
 Identities = 56/155 (36%), Positives = 85/155 (54%), Gaps = 0/155 (0%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA  1015
             G  T +Q+  A+   T   +L + + L++NY   DG SAL+ AA  G  + + LLL A+A
Sbjct  14    GDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQA  73

Query  1016  QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL  1075
              V+  D NG  PL  AA QG  E V LL+   A +N A+  GQ PL+LA + G+ E  ++
Sbjct  74    TVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEM  133

Query  1076  LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             LL+  +N  +      TP+  A + G +   +LL+
Sbjct  134   LLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLL  168


 Score = 73.6 bits (179),  Expect = 8e-13
 Identities = 51/158 (32%), Positives = 81/158 (51%), Gaps = 9/158 (5%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  AA  G++ L+++LL  +   ++    +G   L+ AA  G  + VRLLL A A VNAA
Sbjct  53    LHHAALGGSLELIALLLEAQAT-VDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAA  111

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA-  1079
               +G  PL  AA  GH+E  E+L+ + +N        +TPL LAC+ G  +  +LLL + 
Sbjct  112   SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSH  171

Query  1080  -------GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                    G  +     +  TP+H A   G+ + ++ L+
Sbjct  172   LCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLL  209


 Score = 57.4 bits (137),  Expect = 6e-08
 Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 0/97 (0%)

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             VN  D +GF+ L  AA  G  E + LL+   A ++     G  PL+ A   G  E ++LL
Sbjct  42    VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL  101

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
             L A    +  + DG  P+H A   G+ +  ++L+ H+
Sbjct  102   LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQ  138


>gi|10719883|sp|P57078|RIPK4_HUMAN  Serine/threonine-protein kinase RIPK4 (Receptor-interacting serine/threonine-protein 
kinase 4) (Ankyrin repeat domain protein 
3) (PKC-delta-interacting protein kinase)
Length=832

 Score = 88.6 bits (218),  Expect = 2e-17
 Identities = 63/213 (29%), Positives = 108/213 (50%), Gaps = 11/213 (5%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA-QV  1017
             T +  A   G   ++ +LL   G+D++   +D    L+ AA  GH   V+LL       V
Sbjct  587   TPMHVACQHGQENIVRILLRR-GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSV  645

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             NA   +G TPL  AA +GH+    +LI   +++N  +   QTPL++A + G+    +LLL
Sbjct  646   NAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL  705

Query  1078  EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR--IPAHGnsfneeesessVFDLDG  1135
               G  +   T+DG+T +H A   G++ ++KLL+  +  + A G         ++     G
Sbjct  706   HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAH---G  762

Query  1136  GEESPEGISKPVVPADLINHANREGWTAAHIAA  1168
               E    + + +V AD+I+  + +G +A H+AA
Sbjct  763   HSE----VVEELVSADVIDLFDEQGLSALHLAA  791


 Score = 77.0 bits (188),  Expect = 7e-14
 Identities = 41/125 (32%), Positives = 70/125 (56%), Gaps = 0/125 (0%)

Query  985   NYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLI  1044
             N S   G + L+ A +      V LLL+ +  VNA D++ +T L  AA  G      LL+
Sbjct  513   NLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLL  572

Query  1045  SYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVD  1104
               +A++N     G+TP+++AC++G +  +++LL  G + S++  D W P+H A   G++ 
Sbjct  573   EKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLP  632

Query  1105  SLKLL  1109
              +KLL
Sbjct  633   IVKLL  637


 Score = 74.7 bits (182),  Expect = 4e-13
 Identities = 50/168 (29%), Positives = 79/168 (47%), Gaps = 2/168 (1%)

Query  945   LLMSGGPAPLAGRPTLL--QQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG  1002
             LL  G    L G+   L    AA QG++ ++ +L  + G+ +N    DG + L+ AA+ G
Sbjct  604   LLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG  663

Query  1003  HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY  1062
             H    R+L+   + VN       TPL  AA  GH     LL+   A        G T L+
Sbjct  664   HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALH  723

Query  1063  LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             LA +NG+   +KLL+E   +   +     T +H A   G+ + ++ L+
Sbjct  724   LAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV  771


 Score = 74.3 bits (181),  Expect = 5e-13
 Identities = 46/154 (29%), Positives = 84/154 (54%), Gaps = 2/154 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+ +   +LL E+   +N    +G + ++ A ++G  + VR+LL     V+
Sbjct  554   TALHFAAQNGDESSTRLLL-EKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVS  612

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDA-NINHAADGGQTPLYLACKNGNKECIKLLL  1077
                K+ + PL  AA QGH   V+LL      ++N     G+TPL+LA + G+    ++L+
Sbjct  613   LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILI  672

Query  1078  EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY  1111
             +  ++ +V +    TP+H A +TG+  + +LL++
Sbjct  673   DLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLH  706


 Score = 71.2 bits (173),  Expect = 4e-12
 Identities = 55/188 (29%), Positives = 87/188 (46%), Gaps = 4/188 (2%)

Query  926   GASDSLLVTASGWSPSLTPLLMSGGPAPLAGR--PTLLQQAAAQGNVTLLSMLLNEEGLD  983
             GAS   L   +G       LL++     L+ R   T L  A  +    ++ +LL  + + 
Sbjct  486   GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARK-IS  544

Query  984   INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL  1043
             +N   ED  +AL+ AA+NG     RLLL   A VN  D  G TP+  A   G    V +L
Sbjct  545   VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL  604

Query  1044  ISYDANINHAADGGQTPLYLACKNGNKECIKLLL-EAGTNRSVKTTDGWTPVHAAVDTGN  1102
             +    +++        PL+ A   G+   +KLL  + G + + +T DG TP+H A   G+
Sbjct  605   LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGH  664

Query  1103  VDSLKLLM  1110
                 ++L+
Sbjct  665   YRVARILI  672


 Score = 62.8 bits (151),  Expect = 1e-09
 Identities = 48/159 (30%), Positives = 78/159 (49%), Gaps = 3/159 (1%)

Query  954   LAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA  1013
             L GR T L  AA +G+  +  +L++    D+N       + L+ AA+ GHT   RLLL  
Sbjct  650   LDGR-TPLHLAAQRGHYRVARILIDLCS-DVNVCSLLAQTPLHVAAETGHTSTARLLLHR  707

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
              A   A   +G+T L  AA  GH   V+LL+   A++       QT L+LA  +G+ E +
Sbjct  708   GAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVV  767

Query  1074  KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             + L+ A     +    G + +H A    +  +++ L+ H
Sbjct  768   EELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRH  805


 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 4/123 (3%)

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKL  1108
             +++ A D G + L+LA + G +EC K LL    N ++    G TP+H AV+      ++L
Sbjct  478   DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL  537

Query  1109  LMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAA  1168
             L+  +I  +    ++  +    F    G+ES   +   +     +N  + EG T  H+A 
Sbjct  538   LLARKISVNAKDEDQWTALH--FAAQNGDESSTRLL--LEKNASVNEVDFEGRTPMHVAC  593

Query  1169  SKG  1171
               G
Sbjct  594   QHG  596


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 2/60 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AAA G+  ++  L++ + +D+    E G SAL+ AA+  H   V  LL   A +N
Sbjct  753   TALHLAAAHGHSEVVEELVSADVIDL--FDEQGLSALHLAAQGRHAQTVETLLRHGAHIN  810


>gi|20531991|sp|Q8WXI3|ASB10_HUMAN  Ankyrin repeat and SOCS box protein 10 (ASB-10)
Length=429

 Score = 87.4 bits (215),  Expect = 5e-17
 Identities = 52/142 (36%), Positives = 76/142 (53%), Gaps = 3/142 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA++G+  +L +LL         S   G +AL+ A   GHT CV +LL A A  N
Sbjct  118   TPLHVAASRGHTEVLRLLLRRRARPD--SAPGGRTALHEACAAGHTACVHVLLVAGADPN  175

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANIN-HAADGGQTPLYLACKNGNKECIKLLL  1077
              AD++G  PL      G  EC ELL+ + A ++  + +  +TPL++A + G+ E   LLL
Sbjct  176   IADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLL  235

Query  1078  EAGTNRSVKTTDGWTPVHAAVD  1099
               G     +  +GWTP+ AA D
Sbjct  236   RRGACPDARNAEGWTPLLAACD  257


 Score = 67.4 bits (163),  Expect = 6e-11
 Identities = 45/123 (36%), Positives = 66/123 (53%), Gaps = 2/123 (1%)

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDA  1048
             E+  + L+ AA  GHT+ +RLLL   A+ ++A   G T L  A A GH  CV +L+   A
Sbjct  114   EELTTPLHVAASRGHTEVLRLLLRRRARPDSA-PGGRTALHEACAAGHTACVHVLLVAGA  172

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT-TDGWTPVHAAVDTGNVDSLK  1107
             + N A   G+ PL+L    G  EC +LLL  G     ++  +  TP+H A   G+V+   
Sbjct  173   DPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELAD  232

Query  1108  LLM  1110
             LL+
Sbjct  233   LLL  235


 Score = 62.0 bits (149),  Expect = 2e-09
 Identities = 53/181 (29%), Positives = 83/181 (45%), Gaps = 19/181 (10%)

Query  935   ASGWSPSLTPLLMSGGPAPLAG----RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCED  990
             A+G +  +  LL++G    +A     RP  L      G +    +LL         S E+
Sbjct  157   AAGHTACVHVLLVAGADPNIADQDGKRP--LHLCRGPGTLECAELLLRFGARVDGRSEEE  214

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAA----------AAQGHFECV  1040
               + L+ AA+ GH +   LLL   A  +A +  G+TPL AA          A      C+
Sbjct  215   EETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCL  274

Query  1041  EL---LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
             +L   L+S  A+ + A    Q PL+LAC+ G+   ++LLL  G + +     G TP+H A
Sbjct  275   QLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA  334

Query  1098  V  1098
             +
Sbjct  335   L  335


>gi|61213003|sp|Q8WXD9|CSKI1_HUMAN  Caskin-1 (CASK-interacting protein 1)
Length=1431

 Score = 87.0 bits (214),  Expect = 7e-17
 Identities = 52/155 (33%), Positives = 86/155 (55%), Gaps = 3/155 (1%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA  1015
             G    L Q    G   LL    + + +++N+   DG SAL+ AA NG+T+ + LLL A+A
Sbjct  17    GTAQRLLQRPRPGKAKLLG---STKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQA  73

Query  1016  QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL  1075
              V+  D  G  PL  AA QG  E ++L++   + +N  +D G  PL+LA ++G+ +  ++
Sbjct  74    AVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEM  133

Query  1076  LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             LL+  +N  +    G TP+  A + G V  ++LL+
Sbjct  134   LLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL  168


 Score = 79.3 bits (194),  Expect = 1e-14
 Identities = 51/158 (32%), Positives = 81/158 (51%), Gaps = 9/158 (5%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  AA  GN  L+S+LL  +   ++     G   L+ AA  G  + ++L+L A + VN  
Sbjct  53    LHHAALNGNTELISLLLEAQAA-VDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIP  111

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
                G  PL  AA  GH++  E+L+ + +N     + G+TPL LAC+ G    ++LLL + 
Sbjct  112   SDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSN  171

Query  1081  ------TNRSVKTTD--GWTPVHAAVDTGNVDSLKLLM  1110
                     R    TD  G +P+H A   G++D ++LL+
Sbjct  172   MCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL  209


 Score = 78.6 bits (192),  Expect = 2e-14
 Identities = 56/165 (33%), Positives = 87/165 (52%), Gaps = 10/165 (6%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  AA QG    + ++L + G  +N   ++GH  L+ AA++GH D   +LL  ++     
Sbjct  86    LHYAAWQGRKEPMKLVL-KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMV  144

Query  1021  DKNGFTPLCAAAAQGHFECVELLIS-------YDANINHAAD-GGQTPLYLACKNGNKEC  1072
             D +G TPL  A   G    V+LL+S        +     A D  G +PL+LA KNG+ + 
Sbjct  145   DNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDI  204

Query  1073  IKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAH  1117
             I+LLL+AG + + +T  G T +H A   G  + ++LL+   I AH
Sbjct  205   IRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH  248


 Score = 63.5 bits (153),  Expect = 8e-10
 Identities = 33/97 (34%), Positives = 56/97 (57%), Gaps = 0/97 (0%)

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             VN  D +GF+ L  AA  G+ E + LL+   A ++   + G  PL+ A   G KE +KL+
Sbjct  42    VNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLV  101

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
             L+AG+  ++ + +G  P+H A   G+ D  ++L+ H+
Sbjct  102   LKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQ  138


 Score = 50.8 bits (120),  Expect = 6e-06
 Identities = 38/103 (36%), Positives = 49/103 (47%), Gaps = 5/103 (4%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             +G S L+ AAKNGH D +RLLL A   +N   K+G T L  AA  G  E V LL+    N
Sbjct  188   NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGIN  246

Query  1050  INHAADGGQTPL----YLACKNGNKECIKLLLEAGTNRSVKTT  1088
              +      QT L           ++E  +LL EA     V+ T
Sbjct  247   AHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRAT  289


>gi|68565551|sp|Q9Y283|INVS_HUMAN  Inversin (Inversion of embryo turning homolog) (Nephrocystin-2)
Length=1065

 Score = 84.3 bits (207),  Expect = 5e-16
 Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 0/157 (0%)

Query  954   LAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA  1013
             L GR + +  A    +  L +ML  +  +DIN + + G +AL++AA +GH   V+LLL  
Sbjct  320   LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN  379

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
              AQV+A D    TPL  A   GH + ++ LI   A ++     G + L+ A   GN +  
Sbjct  380   NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC  439

Query  1074  KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             ++L+E   N +V+   G TP+  A   G ++ + +LM
Sbjct  440   QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM  476


 Score = 77.4 bits (189),  Expect = 6e-14
 Identities = 45/152 (29%), Positives = 83/152 (54%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+V+ + +LL E    ++ +    H+ L+ A + GH D ++ L+   A+V+
Sbjct  359   TALHAAALSGHVSTVKLLL-ENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD  417

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D++G + L  AA  G+ +  ++LI    N N     G+TPL  A   G   C+ +L+E
Sbjct  418   LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME  477

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                + +++  +G T +H + + G +D++KLL+
Sbjct  478   NNADPNIQDKEGRTALHWSCNNGYLDAIKLLL  509


 Score = 75.1 bits (183),  Expect = 3e-13
 Identities = 61/207 (29%), Positives = 98/207 (47%), Gaps = 12/207 (5%)

Query  919   SASSCRPGASDSLLVTASGWSPSL-----TPLLMS---GGPAPLAGRPTLLQQAAAQGNV  970
             S  SC   + D+L  T   W+  L       LL+     G  P   +       AAQ N 
Sbjct  242   SYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNF  301

Query  971   T-LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS--AEAQVNAADKNGFTP  1027
                + + L    +  +   E   S +++A K G  D +R +LS  ++  +N ADK G T 
Sbjct  302   AETVKVFLKHPSVKDDSDLEGRTSFMWAAGK-GSDDVLRTMLSLKSDIDINMADKYGGTA  360

Query  1028  LCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT  1087
             L AAA  GH   V+LL+  +A ++       TPL+ AC+ G+K+ I+ L++ G    +  
Sbjct  361   LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD  420

Query  1088  TDGWTPVHAAVDTGNVDSLKLLMYHRI  1114
              DG + +H A   GN D  ++L+ ++I
Sbjct  421   QDGHSLLHWAALGGNADVCQILIENKI  447


 Score = 70.9 bits (172),  Expect = 5e-12
 Identities = 46/156 (29%), Positives = 82/156 (52%), Gaps = 3/156 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L +A   G+  ++  L+ + G  ++   +DGHS L+ AA  G+ D  ++L+  +   N
Sbjct  392   TPLFRACEMGHKDVIQTLI-KGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN  450

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D  G TPL  AA  G+  C+ +L+  +A+ N     G+T L+ +C NG  + IKLLL+
Sbjct  451   VQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLD  510

Query  1079  --AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
               A  N+     + +TP+  A+     + ++ ++ H
Sbjct  511   FAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEH  546


 Score = 60.1 bits (144),  Expect = 9e-09
 Identities = 45/155 (29%), Positives = 77/155 (49%), Gaps = 3/155 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA-EAQV  1017
             T L  A A GNVT++ +L + E  +I        + L+ AA  GH   V LLL   ++  
Sbjct  223   TPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGT  282

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
               +D  G TPL  AA     E V++ + + +  + +   G+T    A   G+ + ++ +L
Sbjct  283   IPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTML  342

Query  1078  EAGTNRSVKTTD--GWTPVHAAVDTGNVDSLKLLM  1110
                ++  +   D  G T +HAA  +G+V ++KLL+
Sbjct  343   SLKSDIDINMADKYGGTALHAAALSGHVSTVKLLL  377


 Score = 57.0 bits (136),  Expect = 8e-08
 Identities = 47/159 (29%), Positives = 78/159 (49%), Gaps = 9/159 (5%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS--AEAQ  1016
             T L  AA +GN   + +LL      +    E+  + L+   ++    C+ LLL   A  +
Sbjct  83    TALHLAAQKGNYRFMKLLLTRRANWMQKDLEE-MTPLHLTTRHRSPKCLALLLKFMAPGE  141

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKEC---I  1073
             V+  DKN  T L  +A   + E V+LLI +D+NI      G+ PL+ A  + +      +
Sbjct  142   VDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTV  201

Query  1074  KLLLEAGTNRSV---KTTDGWTPVHAAVDTGNVDSLKLL  1109
             + +L+A    S+   +  +G TP+H AV  GNV  + +L
Sbjct  202   RCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL  240


 Score = 56.2 bits (134),  Expect = 1e-07
 Identities = 60/223 (26%), Positives = 105/223 (47%), Gaps = 11/223 (4%)

Query  957   RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCV---RLLLSA  1013
             + T L  +A   N   + +L+  +  +I     +G   L+ AA +     V   R +L A
Sbjct  149   KQTALHWSAYYNNPEHVKLLIKHDS-NIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDA  207

Query  1014  ---EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDA-NINHAADGGQTPLYLACKNGN  1069
                E+ +N  D  G TPL  A A G+   V++L SY++ NI    +  +TPL+ A   G+
Sbjct  208   APTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGH  267

Query  1070  KECIKLLLEAGTNRSVKT-TDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeeses  1128
              + + LLLE   + ++ + + G TP+H A  +   +++K+ + H  P+  +  + E   S
Sbjct  268   AQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKH--PSVKDDSDLEGRTS  325

Query  1129  sVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKG  1171
              ++    G +        +     IN A++ G TA H AA  G
Sbjct  326   FMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSG  368


 Score = 54.7 bits (130),  Expect = 4e-07
 Identities = 36/124 (29%), Positives = 57/124 (45%), Gaps = 1/124 (0%)

Query  993   SALYSAAKNGHTDCV-RLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANIN  1051
             S +++AA NG    + RL++   A  +  D+ G TPL         +C + L+   A++N
Sbjct  16    SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN  75

Query  1052  HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY  1111
                   +T L+LA + GN   +KLLL    N   K  +  TP+H      +   L LL+ 
Sbjct  76    KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK  135

Query  1112  HRIP  1115
                P
Sbjct  136   FMAP  139


 Score = 50.4 bits (119),  Expect = 7e-06
 Identities = 34/125 (27%), Positives = 60/125 (48%), Gaps = 2/125 (1%)

Query  977   LNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGH  1036
             L + G D+N +     +AL+ AA+ G+   ++LLL+  A     D    TPL        
Sbjct  67    LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRS  126

Query  1037  FECVELLISYDA--NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPV  1094
              +C+ LL+ + A   ++      QT L+ +    N E +KLL++  +N  +   +G  P+
Sbjct  127   PKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPL  186

Query  1095  HAAVD  1099
             H A +
Sbjct  187   HWAAN  191


>gi|47117901|sp|Q8WXK1|ASB15_HUMAN  Ankyrin repeat and SOCS box protein 15 (ASB-15)
Length=588

 Score = 83.6 bits (205),  Expect = 8e-16
 Identities = 54/152 (35%), Positives = 78/152 (51%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A  +G+  ++S L+ +    ++  C    SA++ AAK G  D V LLL     V+
Sbjct  146   TPLLIAVKKGSYDMVSTLI-KHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVH  204

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D  G TPL  AA  GH + +E LI    ++   AD G + L+ A   GN +CI LLLE
Sbjct  205   LRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLE  264

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G + +V    G  P+H A   G+  +LK L+
Sbjct  265   YGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI  296


 Score = 69.3 bits (168),  Expect = 2e-11
 Identities = 47/160 (29%), Positives = 78/160 (48%), Gaps = 6/160 (3%)

Query  953   PLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSA--LYSAAKNGHTDCVRLL  1010
             P   R + + +AA QG   ++++LL   G   N    DG     L  AA+ GH D +  L
Sbjct  173   PCVKRWSAMHEAAKQGRKDIVALLLKHGG---NVHLRDGFGVTPLGVAAEYGHCDVLEHL  229

Query  1011  LSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNK  1070
             +     V A   +G + L  AA  G+ +C+ LL+ Y  + N     G  P++ A   G+ 
Sbjct  230   IHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHY  289

Query  1071  ECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
               +K L+   +  +++ + G TP+H+A D  N   L+LL+
Sbjct  290   LALKYLIPVTSKNAIRKS-GLTPIHSAADGQNAQCLELLI  328


 Score = 65.5 bits (158),  Expect = 2e-10
 Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 5/212 (2%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDI-NYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             L +A  Q    +L ++L+     +  +   DG + L  A K G  + VR LL      N 
Sbjct  80    LHEAVVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNT  139

Query  1020  ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA  1079
              +  G TPL  A  +G ++ V  LI ++ +++       + ++ A K G K+ + LLL+ 
Sbjct  140   KNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKH  199

Query  1080  GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEES  1139
             G N  ++   G TP+  A + G+ D L+    H I   G+     +  +SV     G  +
Sbjct  200   GGNVHLRDGFGVTPLGVAAEYGHCDVLE----HLIHKGGDVLALADDGASVLFEAAGGGN  255

Query  1140  PEGISKPVVPADLINHANREGWTAAHIAASKG  1171
             P+ IS  +      N  NR G    H AA +G
Sbjct  256   PDCISLLLEYGGSGNVPNRAGHLPIHRAAYEG  287


 Score = 65.1 bits (157),  Expect = 3e-10
 Identities = 50/163 (30%), Positives = 82/163 (50%), Gaps = 14/163 (8%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             ++L +AA  GN   +S+LL E G   N     GH  ++ AA  GH   ++ L+   ++ N
Sbjct  245   SVLFEAAGGGNPDCISLLL-EYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSK-N  302

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANIN---------HAADGGQTPLYLACKNGN  1069
             A  K+G TP+ +AA   + +C+ELLI    ++N            D  +T LY A  N +
Sbjct  303   AIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSCDDERKTALYFAVSNND  362

Query  1070  KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
               C ++LL AG + ++   D    +  AV   N + ++LL+ H
Sbjct  363   VHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSH  402


 Score = 53.9 bits (128),  Expect = 7e-07
 Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 2/120 (1%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLI--SYDANINH  1052
             L  A K GH   ++  +  +  ++ AD+ G+ PL  A  Q   + +E+++  SY      
Sbjct  47    LVEAIKQGHILELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF  106

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                 G+TPL LA K G  E ++ LLE G   + K   G TP+  AV  G+ D +  L+ H
Sbjct  107   KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH  166


 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 9/108 (8%)

Query  1012  SAEAQVNAADKNGFTPLCA-------AAAQGHFECVELLISYDANINHAADGGQTPLYLA  1064
             S EA   A     F PL A       A  QGH   ++  + Y   ++ A + G  PL+ A
Sbjct  24    SIEASKTALCPERFVPLSAQNRKLVEAIKQGHILELQEYVKYKYAMDEADEKGWFPLHEA  83

Query  1065  CKNGNKECIKLLLEAG--TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                  ++ ++++L+A   T    KT DG TP+  AV  G V++++ L+
Sbjct  84    VVQPIQQILEIVLDASYKTLWEFKTCDGETPLTLAVKAGLVENVRTLL  131


>gi|25090571|sp|Q9H9B1|EHMT1_HUMAN  Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (Histone 
H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic 
histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like 
protein 1) (GLP1)
Length=1267

 Score = 82.4 bits (202),  Expect = 2e-15
 Identities = 54/164 (32%), Positives = 89/164 (54%), Gaps = 7/164 (4%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  AA  G+V +  ML+ + G +I+   ED  + L  AA+N H + V+ L+ A A V+  
Sbjct  746   LHAAAEAGHVDICHMLV-QAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK  804

Query  1021  DKNGFTPLCAAAAQGHFECVELLISY-DANINHAADGGQTPLYLACKNGNKECIKLLLEA  1079
             D  G T L  AA +GH+E V+ L+S    ++N   DGG TP+  A +  + + +KLLL  
Sbjct  805   DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK  864

Query  1080  GTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM-----YHRIPAHG  1118
             G++ +++  +    +H A  +G VD  ++L+      H +  HG
Sbjct  865   GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHG  908


 Score = 82.0 bits (201),  Expect = 2e-15
 Identities = 56/168 (33%), Positives = 89/168 (52%), Gaps = 4/168 (2%)

Query  946   LMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCE--DGHSALYSAAKNGH  1003
             L S  P  L   P  L  +A QG +  + ++L  +G+D N+  E  +  S L++AA+ GH
Sbjct  696   LDSEKPKKLRFHPKQLYFSARQGELQKVLLML-VDGIDPNFKMEHQNKRSPLHAAAEAGH  754

Query  1004  TDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL  1063
              D   +L+ A A ++   ++  TPL  AA   H E V+ LI   A ++     G T L+L
Sbjct  755   VDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHL  814

Query  1064  ACKNGNKECIKLLLEAG-TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             A K G+ E ++ LL  G  + + +   GWTP+  A +  +VD +KLL+
Sbjct  815   AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLL  862


 Score = 67.0 bits (162),  Expect = 8e-11
 Identities = 38/139 (27%), Positives = 71/139 (51%), Gaps = 0/139 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA +G+  ++  LL+   +D+N   + G + +  A +  H D V+LLLS  + +N
Sbjct  810   TCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN  869

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D      L  AA  G  +  E+L++   +++     G +PL++A +    +C+ L L 
Sbjct  870   IRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLS  929

Query  1079  AGTNRSVKTTDGWTPVHAA  1097
               ++ ++K  +G TP+  A
Sbjct  930   RDSDVTLKNKEGETPLQCA  948


 Score = 57.0 bits (136),  Expect = 8e-08
 Identities = 33/99 (33%), Positives = 58/99 (58%), Gaps = 1/99 (1%)

Query  969   NVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPL  1028
             +V L+ +LL++ G DIN    + +  L+ AA +G  D   +LL+A+  ++A + +G +PL
Sbjct  854   HVDLVKLLLSK-GSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPL  912

Query  1029  CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKN  1067
               AA +  ++CV L +S D+++      G+TPL  A  N
Sbjct  913   HIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLN  951


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 30/143 (20%), Positives = 56/143 (39%), Gaps = 39/143 (27%)

Query  1031  AAAQGHFECVELLI--SYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTT  1088
             +A QG  + V L++    D N        ++PL+ A + G+ +   +L++AG N    + 
Sbjct  714   SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE  773

Query  1089  DGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVV  1148
             D  TP+  A +  +++++K L                                     + 
Sbjct  774   DQRTPLMEAAENNHLEAVKYL-------------------------------------IK  796

Query  1149  PADLINHANREGWTAAHIAASKG  1171
                L++  + EG T  H+AA KG
Sbjct  797   AGALVDPKDAEGSTCLHLAAKKG  819


>gi|20532004|sp|Q9Y575|ASB3_HUMAN  Ankyrin repeat and SOCS box protein 3 (ASB-3)
Length=518

 Score = 82.4 bits (202),  Expect = 2e-15
 Identities = 60/187 (32%), Positives = 95/187 (50%), Gaps = 7/187 (3%)

Query  930   SLLVTASGWSPSLTPLLMSGGPAPLAG---RPTLLQQAAAQGNVTLLSMLLNEEGLDINY  986
             +L + AS     +  +L+  G  P A      T L  A   G + +L +LL + G ++N 
Sbjct  82    ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL-QHGANVNG  140

Query  987   SCED-GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLIS  1045
             S    G ++L+ A+   + + ++LLL   A     D  G TPL  AA  G  E + +LIS
Sbjct  141   SHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILIS  200

Query  1046  YDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVK-TTDGW-TPVHAAVDTGNV  1103
               AN+N  A    TPL++A + G+ +C++LLL +G +  +    D W  P+HAA   G+ 
Sbjct  201   SGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHT  260

Query  1104  DSLKLLM  1110
               L LL+
Sbjct  261   KILDLLI  267


 Score = 79.7 bits (195),  Expect = 1e-14
 Identities = 48/151 (31%), Positives = 84/151 (55%), Gaps = 5/151 (3%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN  1023
             AA +GNV +L  LL ++G  ++ +   G   ++ AA +   +C+++L++A++  N     
Sbjct  17    AAREGNVKVLRKLL-KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK  75

Query  1024  GFTPLCA---AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
              F   CA   AA+QGH++ V++L+   A+ N       TPL+LA +NG  + ++LLL+ G
Sbjct  76    TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG  135

Query  1081  TN-RSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              N     +  GW  +H A    N + +KLL+
Sbjct  136   ANVNGSHSMCGWNSLHQASFQENAEIIKLLL  166


 Score = 75.9 bits (185),  Expect = 2e-13
 Identities = 44/140 (31%), Positives = 75/140 (53%), Gaps = 3/140 (2%)

Query  982   LDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVE  1041
             +D   +  D  S +  AA+ G+   +R LL     V+ AD  G+ P+  AA     EC++
Sbjct  1     MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ  60

Query  1042  LLISYDANINHA---ADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
             +LI+ D++ N+       G   L+LA   G+ + +++LLEAG + +  T +  TP+  AV
Sbjct  61    MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV  120

Query  1099  DTGNVDSLKLLMYHRIPAHG  1118
             + G +D L+LL+ H    +G
Sbjct  121   ENGQIDVLRLLLQHGANVNG  140


 Score = 63.9 bits (154),  Expect = 6e-10
 Identities = 45/127 (35%), Positives = 70/127 (55%), Gaps = 9/127 (7%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS--AEAQ  1016
             T L  AA  G +  LS+L++  G ++N    D  + L+ AA+ GHT CV LLLS  A+  
Sbjct  181   TPLFVAAQYGKLESLSILISS-GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD  239

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQ---TPLYLACKNGNKECI  1073
             +   + +   P+ AAA  GH + ++LLI      N A D G    +P+Y A   G+++C+
Sbjct  240   LYCNEDSWQLPIHAAAQMGHTKILDLLIPLT---NRACDTGLNKVSPVYSAVFGGHEDCL  296

Query  1074  KLLLEAG  1080
             ++LL  G
Sbjct  297   EILLRNG  303


>gi|74762569|sp|Q8NFD2|ANKK1_HUMAN  Ankyrin repeat and protein kinase domain-containing protein 1 
(Protein kinase PKK2) (X-kinase) (SgK288)
Length=765

 Score = 82.4 bits (202),  Expect = 2e-15
 Identities = 66/234 (28%), Positives = 94/234 (40%), Gaps = 41/234 (17%)

Query  941   SLTPLLMSGGP---APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYS  997
             SL  LL S G    A      T L  A  +G V  +  LL + G   +   + G+  L++
Sbjct  508   SLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL-KSGAVPDALDQSGYGPLHT  566

Query  998   AAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGG  1057
             AA  G     ++LL   A +      G+TPL  AA +GH E + LL    AN+       
Sbjct  567   AAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN  626

Query  1058  QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAH  1117
              TPL+LA ++G +  +  LL+ G + +     GWTP+H AV      S+  L+ H    H
Sbjct  627   WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH  686

Query  1118  GnsfneeesessVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKG  1171
                                                    N+ GWT AH+AA KG
Sbjct  687   A-------------------------------------RNKVGWTPAHLAALKG  703


 Score = 81.3 bits (199),  Expect = 4e-15
 Identities = 57/147 (38%), Positives = 80/147 (54%), Gaps = 2/147 (1%)

Query  965   AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG  1024
             AAQ     L  LL   G D N   EDG + L+ AA+NG     RLLL   A V+A ++ G
Sbjct  402   AAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG  461

Query  1025  FTPLCAAAAQGHFECV-ELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNR  1083
             +TPL   AAQ +FE V  LL+S  A+ N     G+TPL++A   G+   +KLL   G   
Sbjct  462   WTPL-HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL  520

Query  1084  SVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
               +  +  TP+H AV+ G V +++ L+
Sbjct  521   DAQQRNLRTPLHLAVERGKVRAIQHLL  547


 Score = 77.4 bits (189),  Expect = 6e-14
 Identities = 51/150 (34%), Positives = 69/150 (46%), Gaps = 1/150 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  AAA+G   +  MLL   G  +      G + L+ AA  GH + + LL  + A + A 
Sbjct  564   LHTAAARGKYLICKMLLRY-GASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGAL  622

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
                 +TPL  AA  G    V  L+   A+ N A   G TPL+LA +      +  LLE  
Sbjct  623   GAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH  682

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              N   +   GWTP H A   GN   LK+L+
Sbjct  683   ANVHARNKVGWTPAHLAALKGNTAILKVLV  712


 Score = 76.6 bits (187),  Expect = 9e-14
 Identities = 49/151 (32%), Positives = 79/151 (52%), Gaps = 1/151 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L    AQG+V  + +LL  E +D++     G++ L  AA++   D   LLL+  A  N
Sbjct  364   TPLHFLVAQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN  422

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D++G+ PL  AA  G      LL+ + A ++     G TPL+LA +N  +   +LL+ 
Sbjct  423   RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS  482

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
                + ++   +G TP+H A   G+V  +KLL
Sbjct  483   RQADPNLHEAEGKTPLHVAAYFGHVSLVKLL  513


 Score = 69.7 bits (169),  Expect = 1e-11
 Identities = 38/122 (31%), Positives = 63/122 (51%), Gaps = 0/122 (0%)

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDA  1048
             E+  + L+     G  + VRLLL+ E  V+    +G+TPL  AA     +   LL+++ A
Sbjct  360   ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA  419

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKL  1108
             + N   + G  PL+ A +NG+    +LLL+ G     +  +GWTP+H A      +  +L
Sbjct  420   DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL  479

Query  1109  LM  1110
             L+
Sbjct  480   LV  481


 Score = 64.7 bits (156),  Expect = 4e-10
 Identities = 45/140 (32%), Positives = 72/140 (51%), Gaps = 1/140 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA +G++ ++  LL E   ++        + L+ AA++G    V  LL   A  N
Sbjct  595   TPLHLAAYKGHLEIIH-LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN  653

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             AA+++G+TPL  A  +  F  V  L+ + AN++     G TP +LA   GN   +K+L+E
Sbjct  654   AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE  713

Query  1079  AGTNRSVKTTDGWTPVHAAV  1098
             AG    V+     TP+  A+
Sbjct  714   AGAQLDVQDGVSCTPLQLAL  733


 Score = 61.2 bits (147),  Expect = 4e-09
 Identities = 39/153 (25%), Positives = 63/153 (41%), Gaps = 37/153 (24%)

Query  1022  KNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGT  1081
             +N  TPL    AQG  E V LL++++ +++     G TPL +A ++   +   LLL  G 
Sbjct  360   ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA  419

Query  1082  NRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPE  1141
             + +    DGW P+H A   G+  + +LL+ H                             
Sbjct  420   DANRVDEDGWAPLHFAAQNGDDGTARLLLDH-----------------------------  450

Query  1142  GISKPVVPADLINHANREGWTAAHIAASKGFKD  1174
                        ++   REGWT  H+AA   F++
Sbjct  451   --------GACVDAQEREGWTPLHLAAQNNFEN  475


 Score = 47.4 bits (111),  Expect = 6e-05
 Identities = 44/135 (32%), Positives = 66/135 (48%), Gaps = 3/135 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G   ++S LL + G D N + + G + L+ A +      V  LL   A V+
Sbjct  628   TPLHLAARHGEEAVVSALL-QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH  686

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A +K G+TP   AA +G+   +++L+   A ++       TPL LA ++  K+ I   LE
Sbjct  687   ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS-RKQGIMSFLE  745

Query  1079  AGTNRSVKTTDGWTP  1093
              G   SV T  G  P
Sbjct  746   -GKEPSVATLGGSKP  759


>gi|20531990|sp|Q8WXH4|ASB11_HUMAN  Ankyrin repeat and SOCS box protein 11 (ASB-11)
Length=323

 Score = 81.6 bits (200),  Expect = 3e-15
 Identities = 58/183 (31%), Positives = 86/183 (46%), Gaps = 38/183 (20%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AAAQG +  L  L+  +G+++N    +  S+L+ A   GH  C + LL   A VN  
Sbjct  69    LHEAAAQGRLLALKTLI-AQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGV  127

Query  1021  DKNGFTPL----CAAAA----------------------------QGHFECVELLISYDA  1048
               +G TPL    C+ +A                            +GH EC+E+L++ + 
Sbjct  128   TVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNV  187

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW--TPVHAAVDTGNVDSL  1106
             NI+H      TPLY+AC     +C+K LLE G +        W  TP+HAA    NV+ +
Sbjct  188   NIDHEVPQLGTPLYVACTYQRVDCVKKLLELGAS---VDHGQWLDTPLHAAARQSNVEVI  244

Query  1107  KLL  1109
              LL
Sbjct  245   HLL  247


 Score = 65.5 bits (158),  Expect = 2e-10
 Identities = 36/127 (28%), Positives = 63/127 (49%), Gaps = 1/127 (0%)

Query  988   CEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYD  1047
             C    S L+ AA  G    ++ L++    VN    N  + L  A   GH  C + L+   
Sbjct  62    CWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENG  121

Query  1048  ANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLK  1107
             A++N     G TPL+ AC +G+  C+ +LLE G    ++     +P+H AV  G+ + ++
Sbjct  122   AHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLA-SPIHEAVKRGHRECME  180

Query  1108  LLMYHRI  1114
             +L+ + +
Sbjct  181   ILLANNV  187


 Score = 48.1 bits (113),  Expect = 4e-05
 Identities = 45/154 (29%), Positives = 68/154 (44%), Gaps = 3/154 (1%)

Query  926   GASDSLLVTASGWSPSLTPLLMSGGPAPLAGR-PTLLQQAAAQGNVTLLSMLLNEEGLDI  984
             GA+       SG +  +  LL  G  A L     + + +A  +G+   + +LL    ++I
Sbjct  131   GATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILL-ANNVNI  189

Query  985   NYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLI  1044
             ++      + LY A      DCV+ LL   A V+       TPL AAA Q + E + LL 
Sbjct  190   DHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLD-TPLHAAARQSNVEVIHLLT  248

Query  1045  SYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
              Y AN+      G++ L LA    + E   LL E
Sbjct  249   DYGANLKRRNAQGKSALDLAAPKSSVEQALLLRE  282


>gi|38605718|sp|P53355|DAPK1_HUMAN  Death-associated protein kinase 1 (DAP kinase 1)
Length=1432

 Score = 81.6 bits (200),  Expect = 3e-15
 Identities = 72/256 (28%), Positives = 117/256 (45%), Gaps = 15/256 (5%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA  1015
             G P LL  AA  GN+ +L +L+ + G  I+   + G +A+Y AA++GH D ++ L   + 
Sbjct  379   GTPPLLI-AAGCGNIQILQLLI-KRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKC  436

Query  1016  QVNAADKNGFTPLCAAAAQGHFEC--VELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
              ++  DK+G   L  AA  GH +   V++L S+ +N N      +TPL+ A  +G     
Sbjct  437   PLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCAAWHGYYSVA  496

Query  1074  KLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDL  1133
             K L EAG N ++K  +G TP+  A   G  D ++ L  H    +      ++       L
Sbjct  497   KALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA----CDKDGHIALHL  552

Query  1134  DGGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKDCNLPDALL---AFSHMRVR  1190
                    E I   +     +++ +R G T  H+A     KD N+P  +    A  ++ + 
Sbjct  553   AVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVAC----KDGNMPIVVALCEANCNLDIS  608

Query  1191  RFYSHCSSHLGPPGGI  1206
               Y     HL    GI
Sbjct  609   NKYGRTPLHLAANNGI  624


 Score = 80.5 bits (197),  Expect = 7e-15
 Identities = 48/151 (31%), Positives = 76/151 (50%), Gaps = 1/151 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G  ++   L  E G ++N    +G + L +A+  G+ D V  L    A +N
Sbjct  482   TPLHCAAWHGYYSVAKALC-EAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLN  540

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A DK+G   L  A  +   E ++ L+S    +++    G TPL++ACK+GN   +  L E
Sbjct  541   ACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCE  600

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             A  N  +    G TP+H A + G +D ++ L
Sbjct  601   ANCNLDISNKYGRTPLHLAANNGILDVVRYL  631


 Score = 71.2 bits (173),  Expect = 4e-12
 Identities = 45/134 (33%), Positives = 70/134 (52%), Gaps = 1/134 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A+A+G   ++  L  E G D+N   +DGH AL+ A +    + ++ LLS    V+
Sbjct  515   TPLLTASARGYHDIVECLA-EHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD  573

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D++G TPL  A   G+   V  L   + N++ +   G+TPL+LA  NG  + ++ L  
Sbjct  574   YQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCL  633

Query  1079  AGTNRSVKTTDGWT  1092
              G +    TTDG T
Sbjct  634   MGASVEALTTDGKT  647


 Score = 51.2 bits (121),  Expect = 4e-06
 Identities = 44/168 (26%), Positives = 74/168 (44%), Gaps = 22/168 (13%)

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             VN  +K+G  PL  AA  G+ + ++LLI   + I+    GG   +Y A ++G+ + +K L
Sbjct  372   VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL  431

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGG  1136
              E      VK   G   +H A   G+ D  ++ +     ++ N              D  
Sbjct  432   SENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQ------------DKE  479

Query  1137  EESP---------EGISKPVVPADL-INHANREGWTAAHIAASKGFKD  1174
             EE+P           ++K +  A   +N  NREG T    A+++G+ D
Sbjct  480   EETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHD  527


 Score = 42.0 bits (97),  Expect = 0.003
 Identities = 41/166 (24%), Positives = 71/166 (42%), Gaps = 5/166 (3%)

Query  924   RPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEG  981
             R G +  L  +A G+   +  L   G       +     L  A  +  + ++  LL++ G
Sbjct  511   REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ-G  569

Query  982   LDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVE  1041
               ++Y    G++ L+ A K+G+   V  L  A   ++ ++K G TPL  AA  G  + V 
Sbjct  570   CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR  629

Query  1042  LLISYDANINHAADGGQTPLYLACKNGNKECIKLL--LEAGTNRSV  1085
              L    A++      G+T   LA    ++    LL  L   T+R +
Sbjct  630   YLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGL  675


 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 24/73 (32%), Positives = 39/73 (53%), Gaps = 2/73 (2%)

Query  1043  LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGN  1102
             L +YD  +N     G  PL +A   GN + ++LL++ G+   V+   G   V+ A   G+
Sbjct  367   LSNYD--VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGH  424

Query  1103  VDSLKLLMYHRIP  1115
             VD+LK L  ++ P
Sbjct  425   VDTLKFLSENKCP  437


>gi|20532206|sp|O75832|PSD10_HUMAN  26S proteasome non-ATPase regulatory subunit 10 (26S proteasome 
regulatory subunit p28) (Gankyrin)
Length=226

 Score = 80.5 bits (197),  Expect = 7e-15
 Identities = 51/152 (33%), Positives = 81/152 (53%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A + G+  ++  LL + G+ +N   + G S L+ AA  G  + V+ LL   AQVN
Sbjct  42    TALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN  100

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             A ++NG TPL  AA++   E   +L+   AN +       T ++ A   GN + I +LL 
Sbjct  101   AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY  160

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                + +++ T+G TP+H A D   V+  KLL+
Sbjct  161   YKASTNIQDTEGNTPLHLACDEERVEEAKLLV  192


 Score = 77.4 bits (189),  Expect = 6e-14
 Identities = 43/125 (34%), Positives = 62/125 (49%), Gaps = 0/125 (0%)

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDA  1048
             +D  +AL+ A   GHT+ V  LL     VN  D  G++PL  AA+ G  E V+ L+   A
Sbjct  38    QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA  97

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKL  1108
              +N     G TPL+ A      E   +LLE G N   K     T +H A   GN+  + +
Sbjct  98    QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHI  157

Query  1109  LMYHR  1113
             L+Y++
Sbjct  158   LLYYK  162


 Score = 53.1 bits (126),  Expect = 1e-06
 Identities = 29/101 (28%), Positives = 48/101 (47%), Gaps = 0/101 (0%)

Query  1010  LLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGN  1069
             +L+ ++     D++  T L  A + GH E VE L+     +N   D G +PL++A   G 
Sbjct  26    ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR  85

Query  1070  KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              E +K LL  G   +    +G TP+H A      +   +L+
Sbjct  86    DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL  126


>gi|20531989|sp|Q8WWX0|ASB5_HUMAN  Ankyrin repeat and SOCS box protein 5 (ASB-5)
Length=329

 Score = 79.0 bits (193),  Expect = 2e-14
 Identities = 59/183 (32%), Positives = 87/183 (47%), Gaps = 36/183 (19%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA+QG +  L  LL++ G ++N    D  + L+ A    H  C R LL A A VNA 
Sbjct  74    LHEAASQGRLLALRTLLSQ-GYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAI  132

Query  1021  DKNGFTPL----------CA----------------------AAAQGHFECVELLISYDA  1048
               +G TPL          CA                      AA++GH EC+++LIS+  
Sbjct  133   TIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGI  192

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW-TPVHAAVDTGNVDSLK  1107
             +++       TPLY+AC +    CI  LL AG +  V+    W TP+HAA    + + + 
Sbjct  193   DVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGAD--VQKGKYWDTPLHAAAQQSSTEIVN  250

Query  1108  LLM  1110
             LL+
Sbjct  251   LLL  253


 Score = 68.2 bits (165),  Expect = 3e-11
 Identities = 41/118 (34%), Positives = 57/118 (48%), Gaps = 1/118 (0%)

Query  993   SALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH  1052
             S L+ AA  G    +R LLS    VNA   +  TPL  A    H  C   L+   AN+N 
Sbjct  72    SPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNA  131

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                 G TPL+ AC  G+  C +LLLE G    +++    +P H A   G+ + L +L+
Sbjct  132   ITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLP-SPTHEAASKGHHECLDILI  188


>gi|41017262|sp|O14974|MYPT1_HUMAN  Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase 
targeting subunit 1) (Myosin phosphatase target subunit 
1) (Protein phosphatase myosin-binding subunit)
Length=1030

 Score = 78.6 bits (192),  Expect = 2e-14
 Identities = 62/210 (29%), Positives = 95/210 (45%), Gaps = 32/210 (15%)

Query  931   LLVTASGWSPSLTPLLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSC  988
             L   +SG +  +  LL  G     A     T L QA    NV ++  L+ E G +IN   
Sbjct  45    LAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLV-ENGANINQPD  103

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECV--------  1040
              +G   L++AA  G+ D    L+   A V A +  G TPL  A  +   E +        
Sbjct  104   NEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQG  163

Query  1041  ----------ELLISYDA----------NINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
                       E ++  DA          ++ HA  GG T L++A   G  E +KLL++AG
Sbjct  164   VDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGG-TALHVAAAKGYTEVLKLLIQAG  222

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              + ++K  DGWTP+HAA   G  ++ ++L+
Sbjct  223   YDVNIKDYDGWTPLHAAAHWGKEEACRILV  252


 Score = 58.9 bits (141),  Expect = 2e-08
 Identities = 49/192 (25%), Positives = 87/192 (45%), Gaps = 24/192 (12%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             D  +   +A  +G TD V  LL   A +N A+ +G T L  A    + + V+ L+   AN
Sbjct  39    DDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGAN  98

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             IN   + G  PL+ A   G  +  + L+  G +     ++G TP    +D    ++++ L
Sbjct  99    INQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTP----LDIAEEEAMEEL  154

Query  1110  MYHRIPAHGnsfneeesessVFDLDGGEESPEGI----SKPVVPADLIN---HANREGWT  1162
             + + +   G             D++   +  E I    ++  + +  IN   HA + G T
Sbjct  155   LQNEVNRQG------------VDIEAARKEEERIMLRDARQWLNSGHINDVRHA-KSGGT  201

Query  1163  AAHIAASKGFKD  1174
             A H+AA+KG+ +
Sbjct  202   ALHVAAAKGYTE  213


 Score = 46.6 bits (109),  Expect = 1e-04
 Identities = 27/76 (35%), Positives = 42/76 (55%), Gaps = 0/76 (0%)

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDA  1048
             + G +AL+ AA  G+T+ ++LL+ A   VN  D +G+TPL AAA  G  E   +L+    
Sbjct  197   KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC  256

Query  1049  NINHAADGGQTPLYLA  1064
             ++      GQT   +A
Sbjct  257   DMEMVNKVGQTAFDVA  272


 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 35/124 (28%), Positives = 59/124 (47%), Gaps = 15/124 (12%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK----NGHTDCVRLLLSAE  1014
             T L  A  +    LL   +N +G+DI  + ++    +   A+    +GH + VR      
Sbjct  141   TPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHA----  196

Query  1015  AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIK  1074
                    K+G T L  AAA+G+ E ++LLI    ++N     G TPL+ A   G +E  +
Sbjct  197   -------KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACR  249

Query  1075  LLLE  1078
             +L++
Sbjct  250   ILVD  253


 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AAA+G   +L +L+ + G D+N    DG + L++AA  G  +  R+L+     + 
Sbjct  201   TALHVAAAKGYTEVLKLLI-QAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDME  259

Query  1019  AADKNGFT  1026
               +K G T
Sbjct  260   MVNKVGQT  267


>gi|82582303|sp|Q59H18|TNI3K_HUMAN  Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase) 
(Cardiac ankyrin repeat kinase)
Length=936

 Score = 77.4 bits (189),  Expect = 6e-14
 Identities = 53/154 (34%), Positives = 75/154 (48%), Gaps = 3/154 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A  + N  L++ LL+  G DI      G +AL+ A   GH +   +LL   A VN
Sbjct  204   TALHLAVYKDNAELITSLLHS-GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVN  262

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D   FTPL  AA  GH +   LL+ + A++N + + G  PL+LA   G     KLL+E
Sbjct  263   IQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME  322

Query  1079  AGTNRSVKTTDG--WTPVHAAVDTGNVDSLKLLM  1110
              G+   V   D     P+H     G+ D +K L+
Sbjct  323   EGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLL  356


 Score = 62.8 bits (151),  Expect = 1e-09
 Identities = 39/131 (29%), Positives = 66/131 (50%), Gaps = 0/131 (0%)

Query  980   EGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFEC  1039
             +GL  +    +G +AL+ A    + + +  LL + A +      G T L  A   GH E 
Sbjct  191   KGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEA  250

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVD  1099
              ++L+ + AN+N       TPL++A   G+++  +LLL+ G + +V    G  P+H A  
Sbjct  251   ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASA  310

Query  1100  TGNVDSLKLLM  1110
              G ++  KLLM
Sbjct  311   KGFLNIAKLLM  321


 Score = 57.0 bits (136),  Expect = 8e-08
 Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 1/130 (0%)

Query  982   LDINYSCEDGHSALYSAAK-NGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECV  1040
             +++NY  E+G S L+      G    +R L+    + +   +NGFT L  A  + + E +
Sbjct  159   VNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELI  218

Query  1041  ELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDT  1100
               L+   A+I     GG T L++A   G+ E   +LL+ G N +++    +TP+H A   
Sbjct  219   TSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYY  278

Query  1101  GNVDSLKLLM  1110
             G+    +LL+
Sbjct  279   GHEQVTRLLL  288


 Score = 53.1 bits (126),  Expect = 1e-06
 Identities = 42/157 (26%), Positives = 75/157 (47%), Gaps = 7/157 (4%)

Query  961   LQQAAAQGNVTLLSMLLNEEG-LDINYSCEDGHSALYSAAKNGHTDCVRLLLSA--EAQV  1017
             L  A+A+G + +  +L+ E    D+N    + H  L+  ++ GH D V+ LL +  E Q 
Sbjct  305   LHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQP  364

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG--GQTPLYLACKNGNK-ECIK  1074
             +  +  G TPL  A   G FE  + +I      +   +    +T  + AC  G   + +K
Sbjct  365   HVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVK  424

Query  1075  LLLEAGT-NRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              LL+    N + +  DG T +H+A   G++  ++ L+
Sbjct  425   FLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL  461


 Score = 44.7 bits (104),  Expect = 4e-04
 Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 10/98 (10%)

Query  959   TLLQQAAAQG-NVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             T    A   G ++ L+  LL++  ++IN+   DGH+ L+SA  +GH   V+ LL   A +
Sbjct  408   TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADM  467

Query  1018  N---------AADKNGFTPLCAAAAQGHFECVELLISY  1046
             N         + +K+  T L  A  +GH   V LL  Y
Sbjct  468   NLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHY  505


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 20/64 (31%), Positives = 35/64 (54%), Gaps = 1/64 (1%)

Query  1049  NINHAADGGQTPLYLACKNGNKEC-IKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLK  1107
             N+N+  + G + L+L C  G K+  I+ L+  G   S  T +G+T +H AV   N + + 
Sbjct  160   NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT  219

Query  1108  LLMY  1111
              L++
Sbjct  220   SLLH  223


>gi|14424230|sp|Q9Y2G4|ANKR6_HUMAN  Ankyrin repeat domain protein 6
Length=692

 Score = 76.6 bits (187),  Expect = 9e-14
 Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 5/186 (2%)

Query  928   SDSLLVTA-SGWSPSLTPLLMSGGPAPLA--GRPTLLQQAAAQGNVTLLSMLLNEEGLDI  984
             S+ LLV A  G + ++  L+  G    +   GR T L  AA +G++ ++ +LL + G D+
Sbjct  11    SERLLVAAYKGQTENVVQLINKGARVAVTKHGR-TPLHLAANKGHLPVVQILL-KAGCDL  68

Query  985   NYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLI  1044
             +   +   +AL+ A   G+T+ +  L+     ++  DK+G T L  A+  G  +  +LL+
Sbjct  69    DVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLV  128

Query  1045  SYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVD  1104
                AN+      G T L+LAC+N + +  ++LL AG+   +K   G T +H A    ++ 
Sbjct  129   KAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLS  188

Query  1105  SLKLLM  1110
              ++LL+
Sbjct  189   IIRLLL  194


 Score = 66.2 bits (160),  Expect = 1e-10
 Identities = 43/151 (28%), Positives = 77/151 (50%), Gaps = 1/151 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L +A+  G  +  + LL + G ++    + G++AL+ A +N H+   R+LL A ++ +
Sbjct  110   TALHEASWHG-FSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD  168

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               +  G T L  AA   H   + LL++   +++     G T L++A    +K+  K+LLE
Sbjct  169   LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLE  228

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             AG + ++    G TP+  A    N +   LL
Sbjct  229   AGADTTIVNNAGQTPLETARYHNNPEVALLL  259


 Score = 65.9 bits (159),  Expect = 2e-10
 Identities = 50/181 (27%), Positives = 87/181 (48%), Gaps = 3/181 (1%)

Query  932   LVTASGWSPSLTPLLMSGGPAPLA--GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCE  989
             L    G  P +  LL +G    +   G  T L +A   GN  +++ L++E G  ++   +
Sbjct  48    LAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHE-GCALDRQDK  106

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             DG++AL+ A+ +G +   +LL+ A A V A +K G T L  A    H +   +L+   + 
Sbjct  107   DGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSR  166

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
              +   + G T L++A +  +   I+LLL A  +   K   G T +H A    +    K+L
Sbjct  167   ADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKIL  226

Query  1110  M  1110
             +
Sbjct  227   L  227


 Score = 51.2 bits (121),  Expect = 4e-06
 Identities = 34/99 (34%), Positives = 50/99 (50%), Gaps = 1/99 (1%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI  1050
             G + L+ AA+  H   +RLLL+A   V+  ++ G T L  AAA  H +  ++L+   A+ 
Sbjct  174   GDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADT  233

Query  1051  NHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD  1089
                 + GQTPL  A  + N E + LLL      SV   D
Sbjct  234   TIVNNAGQTPLETARYHNNPE-VALLLTKAPQGSVSAGD  271


 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)

Query  1028  LCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT  1087
             L  AA +G  E V  LI+  A +      G+TPL+LA   G+   +++LL+AG +  V+ 
Sbjct  14    LLVAAYKGQTENVVQLINKGARVA-VTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD  72

Query  1088  TDGWTPVHAAVDTGNVDSLKLLMY  1111
                 T +H A   GN + +  L++
Sbjct  73    DGDQTALHRATVVGNTEIIAALIH  96


>gi|20140451|sp|O95271|TNKS1_HUMAN  Tankyrase 1 (TANK1) (Tankyrase I) (TNKS-1) (TRF1-interacting 
ankyrin-related ADP-ribose polymerase)
Length=1327

 Score = 75.9 bits (185),  Expect = 2e-13
 Identities = 74/257 (28%), Positives = 107/257 (41%), Gaps = 28/257 (10%)

Query  866   LTVAPAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRP  925
             +  AP   AVS  + + V   PA +   N P+ S S               P S+SS  P
Sbjct  99    VAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSS---------------PTSSSSSSP  143

Query  926   GA-SDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTL------LQQAAAQGNVTLLSMLLN  978
              +   SL  +      S T  L  G   P  G P +      L +A   G+V+ +  L++
Sbjct  144   SSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVD  203

Query  979   EEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFE  1038
                ++         S L+ AA  G  D V  LL   A V+A D  G  PL  A + GH E
Sbjct  204   AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAE  263

Query  1039  CVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT------  1092
              V LL+   A+ N   +   TPL+ A   G  +   +LL+ G + +++ TDG +      
Sbjct  264   VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD  323

Query  1093  PVHAAVDTGNVDSLKLL  1109
             P   AV TG     +LL
Sbjct  324   PSAKAVLTGEYKKDELL  340


 Score = 72.0 bits (175),  Expect = 2e-12
 Identities = 52/150 (34%), Positives = 75/150 (50%), Gaps = 3/150 (2%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSA-LYSAAKNGHTDCVRLLLSAEAQVNA  1019
             L +A+  G++  +  L + + ++     E  HS  L+ AA       V  LL   A V+A
Sbjct  654   LLEASKAGDLETVKQLCSSQNVNCR-DLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA  712

Query  1020  ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA  1079
              DK G  PL  A + GH+E  ELL+ + A++N A     TPL+ A   G  E  KLLL+ 
Sbjct  713   KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH  772

Query  1080  GTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             G + + K  DG TP+   V  G+ D   LL
Sbjct  773   GADPTKKNRDGNTPLD-LVKEGDTDIQDLL  801


 Score = 70.9 bits (172),  Expect = 5e-12
 Identities = 46/155 (29%), Positives = 72/155 (46%), Gaps = 4/155 (2%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  AA +G +  +  L   E ++   +     + L+ AA   + +    LL   A VNA 
Sbjct  807   LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ  866

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             DK G  PL  AA+ GH +   LLI Y+  +N       TPL+ A + G  +   LLL  G
Sbjct  867   DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG  926

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP  1115
              + ++K  +G TP    +D    D ++ L+   +P
Sbjct  927   ADPTMKNQEGQTP----LDLATADDIRALLIDAMP  957


 Score = 66.6 bits (161),  Expect = 1e-10
 Identities = 54/177 (30%), Positives = 81/177 (45%), Gaps = 26/177 (14%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSAL--------------------YSA  998
             T L +AA +G + +  +LL + G D N    DG SAL                      A
Sbjct  284   TPLHEAAIKGKIDVCIVLL-QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEA  342

Query  999   AKNGHTDCVRLLLSA-EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGG  1057
             A++G+ + +  LL+      +A+D    TPL  AA       V+LL+ + A+++    GG
Sbjct  343   ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG  402

Query  1058  QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW--TPVHAAVDTGNVDSLKLLMYH  1112
               PL+ AC  G+ E  +LLL+ G    V   D W  TP+H A     V+   LL+ H
Sbjct  403   LVPLHNACSYGHYEVTELLLKHGA--CVNAMDLWQFTPLHEAASKNRVEVCSLLLSH  457


 Score = 65.1 bits (157),  Expect = 3e-10
 Identities = 42/106 (39%), Positives = 55/106 (51%), Gaps = 1/106 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA   N+ +   LL E G D+N   + G   L++AA  GH D   LL+     VN
Sbjct  839   TPLHLAAGYNNLEVAEYLL-EHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN  897

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLA  1064
             A DK  FTPL  AA +G  +   LL+++ A+       GQTPL LA
Sbjct  898   ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA  943


 Score = 61.6 bits (148),  Expect = 3e-09
 Identities = 54/182 (29%), Positives = 82/182 (45%), Gaps = 25/182 (13%)

Query  954   LAGR-PTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS  1012
             L GR  T L  AA    V+++  LL+  G D++   + G   L++A   GH +   LL+ 
Sbjct  680   LEGRHSTPLHFAAGYNRVSVVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVR  738

Query  1013  AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGN---  1069
               A VN AD   FTPL  AAA+G +E  +LL+ + A+       G TPL L  K G+   
Sbjct  739   HGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDI  797

Query  1070  ---------------KECIKLLLEAGTNRSVKTTD----GWTPVHAAVDTGNVDSLKLLM  1110
                            K C+  + +  T  ++   D      TP+H A    N++  + L+
Sbjct  798   QDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLL  857

Query  1111  YH  1112
              H
Sbjct  858   EH  859


 Score = 54.3 bits (129),  Expect = 5e-07
 Identities = 43/136 (31%), Positives = 68/136 (50%), Gaps = 6/136 (4%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGH-SALYSAAKNGHT---DCVRLLLSAEAQ  1016
             L QAA + ++  +   L  E   IN+     H +AL+ A  + H        LLL   A 
Sbjct  493   LLQAAREADLAKVKKTLALE--IINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN  550

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             VN  +K+  TPL  AA + H + +E+L  + A +N     GQT L+ A   G+ +  +LL
Sbjct  551   VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL  610

Query  1077  LEAGTNRSVKTTDGWT  1092
             L  G++ S+ +  G+T
Sbjct  611   LSYGSDPSIISLQGFT  626


 Score = 50.8 bits (120),  Expect = 6e-06
 Identities = 33/93 (35%), Positives = 49/93 (52%), Gaps = 1/93 (1%)

Query  957   RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ  1016
             + T L  AA    V ++ +LL + G D++   + G   L++A   GH +   LLL   A 
Sbjct  369   KSTPLHLAAGYNRVRIVQLLL-QHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC  427

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             VNA D   FTPL  AA++   E   LL+S+ A+
Sbjct  428   VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGAD  460


 Score = 46.2 bits (108),  Expect = 1e-04
 Identities = 42/164 (25%), Positives = 62/164 (37%), Gaps = 27/164 (16%)

Query  976   LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTP--------  1027
             +L++ G  +N     G +AL+ AA  GH    RLLLS  +  +     GFT         
Sbjct  576   VLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAV  635

Query  1028  ------------------LCAAAAQGHFECV-ELLISYDANINHAADGGQTPLYLACKNG  1068
                               L  A+  G  E V +L  S + N         TPL+ A    
Sbjct  636   QQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYN  695

Query  1069  NKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                 ++ LL  G +   K   G  P+H A   G+ +  +LL+ H
Sbjct  696   RVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRH  739


 Score = 43.5 bits (101),  Expect = 9e-04
 Identities = 43/176 (24%), Positives = 74/176 (42%), Gaps = 25/176 (14%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCED---------------------GHSALYS  997
             T L +AA++  V + S+LL+        +C                       GHS L  
Sbjct  437   TPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLL-Q  495

Query  998   AAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGH---FECVELLISYDANINHAA  1054
             AA+      V+  L+ E       ++  T L  A A  H    +  ELL+   AN+N   
Sbjct  496   AAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN  555

Query  1055  DGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                 TPL++A +  + + +++L + G   +   T G T +H A   G++ + +LL+
Sbjct  556   KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL  611


>gi|34921898|sp|Q8WWH4|ASZ1_HUMAN  Ankyrin repeat, SAM and basic leucine zipper domain-containing 
protein 1 (Germ cell-specific ankyrin, SAM and basic leucine 
zipper domain-containing protein)
Length=475

 Score = 75.9 bits (185),  Expect = 2e-13
 Identities = 53/166 (31%), Positives = 77/166 (46%), Gaps = 9/166 (5%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTD------CVRLLLS  1012
             T L  AA+  N  L+ +LL+      N S E    ++   A + H        CV LLLS
Sbjct  81    TPLMYAASVANAELVRVLLDRGA---NASFEKDKQSILITACSAHGSEEQILKCVELLLS  137

Query  1013  AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKEC  1072
               A  N A +   TP+  AA  GH + V LL+++ A +N   + G T L  A + G+K  
Sbjct  138   RNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNI  197

Query  1073  IKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHG  1118
             +  LLE G N+ ++T DG  P   A    + +   LL +   P  G
Sbjct  198   VLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLLSFTLNPLEG  243


>gi|25089825|sp|Q96KQ7|EHMT2_HUMAN  Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (Histone 
H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic 
histone-lysine N-methyltransferase 2) (HLA-B associated 
transcript 8) (G9a protein)
Length=1210

 Score = 75.5 bits (184),  Expect = 2e-13
 Identities = 60/224 (26%), Positives = 104/224 (46%), Gaps = 10/224 (4%)

Query  958   PTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDG--HSALYSAAKNGHTDCVRLLLSAEA  1015
             P  L  +  QG +  + ++L +  LD N+  +     + L++AA+ G  +   +LL A A
Sbjct  651   PRQLYLSVKQGELQKVILMLLDN-LDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGA  709

Query  1016  QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL  1075
              +NA DK   TPL  A    H E    ++     +    + G T L+ A K GN E + L
Sbjct  710   NINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSL  769

Query  1076  LLEAG-TNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLD  1134
             LL  G  + + + + GWTP+  A +  +++ +++L+       G      ++E ++    
Sbjct  770   LLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL-----TRGADVTLTDNEENICLHW  824

Query  1135  GGEESPEGISKPVVPADLINHA-NREGWTAAHIAASKGFKDCNL  1177
                     I++ ++ A    HA N  G T  HIAA + + DC L
Sbjct  825   ASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVL  868


 Score = 65.9 bits (159),  Expect = 2e-10
 Identities = 38/134 (28%), Positives = 68/134 (50%), Gaps = 0/134 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  GN+ ++S+LL+   +D+N     G + +  AA++ H + +R+LL+  A V 
Sbjct  753   TCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVT  812

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D      L  A+  G     E+L++   +++     G TPL++A +    +C+ L L 
Sbjct  813   LTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLS  872

Query  1079  AGTNRSVKTTDGWT  1092
              G N  ++  +G T
Sbjct  873   RGANPELRNKEGDT  886


 Score = 60.5 bits (145),  Expect = 7e-09
 Identities = 39/123 (31%), Positives = 61/123 (49%), Gaps = 1/123 (0%)

Query  989   EDGHSALYSAAKNGHTDCVRLLLSA-EAQVNAADKNGFTPLCAAAAQGHFECVELLISYD  1047
             EDG + L+ AAK G+ + V LLLS  +  VNA D  G+TP+  AA   H E + +L++  
Sbjct  749   EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRG  808

Query  1048  ANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLK  1107
             A++    +     L+ A   G+    ++LL A  +       G TP+H A      D + 
Sbjct  809   ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVL  868

Query  1108  LLM  1110
             L +
Sbjct  869   LFL  871


>gi|62511243|sp|Q92625|ANKS1_HUMAN  Ankyrin repeat and SAM domain-containing protein 1 (Odin)
Length=1134

 Score = 75.1 bits (183),  Expect = 3e-13
 Identities = 46/152 (30%), Positives = 83/152 (54%), Gaps = 3/152 (1%)

Query  961   LQQAAAQGNVTLLSMLLNE--EGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             L  AA +G+  ++ +L+++      +N    D  +AL+ AA+ GHT+ V++LL       
Sbjct  117   LHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPT  176

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               +    TPL  AA  G  E V++L++   N+        TPL+LA +NG+K  +++LL+
Sbjct  177   MRNNKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLD  236

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             AG + + +T  G + +H A   G  D +++L+
Sbjct  237   AGMDSNYQTEMG-SALHEAALFGKTDVVQILL  267


 Score = 62.4 bits (150),  Expect = 2e-09
 Identities = 47/168 (27%), Positives = 76/168 (45%), Gaps = 13/168 (7%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG----------HTD  1005
             G+   L +AA  G++  +  LL+ + L   +    G  +      +G          H  
Sbjct  2     GKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHPL  61

Query  1006  CVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLAC  1065
                L +     VN  D  G+TPL  AA  GH + VE+L+  DA  N A   G  PL+LA 
Sbjct  62    SSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAA  121

Query  1066  KNGNKECIKLLLEAG---TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
               G+ + ++LL+  G   T  + +  D  T +H A   G+ + +K+L+
Sbjct  122   WKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLL  169


 Score = 48.9 bits (115),  Expect = 2e-05
 Identities = 31/70 (44%), Positives = 42/70 (60%), Gaps = 2/70 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA  G+  ++ +LL + G+D NY  E G SAL+ AA  G TD V++LL+A   VN
Sbjct  217   TPLHLAARNGHKAVVQVLL-DAGMDSNYQTEMG-SALHEAALFGKTDVVQILLAAGTDVN  274

Query  1019  AADKNGFTPL  1028
               D +G T L
Sbjct  275   IKDNHGLTAL  284


 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 23/69 (33%), Positives = 39/69 (56%), Gaps = 1/69 (1%)

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKL  1108
             N+N     G TPL+ A  NG+K+ +++LL      +V  + G  P+H A   G+   ++L
Sbjct  72    NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRL  131

Query  1109  LMYHRIPAH  1117
             L+ H+ P+H
Sbjct  132   LI-HQGPSH  139


>gi|22001988|sp|Q9Y566|SHAN1_HUMAN  SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin 
receptor-interacting protein) (SSTR-interacting 
protein) (SSTRIP)
Length=2161

 Score = 74.7 bits (182),  Expect = 4e-13
 Identities = 50/156 (32%), Positives = 75/156 (48%), Gaps = 2/156 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK-NGHTDCVRLLLSAEAQV  1017
             T L +AA   +   L+ LL+  G   NY    G + L+  A   G   C  LLL   AQ+
Sbjct  249   TALHKAACARHCLALTALLDLGGSP-NYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQL  307

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
               AD+NG+  +  A  +GH + +E L+ Y A        G T L++      + C ++LL
Sbjct  308   GIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILL  367

Query  1078  EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
               G ++ VK  +G TP   AV  GN +  +L+  HR
Sbjct  368   YRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHR  403


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 18/47 (38%), Positives = 26/47 (55%), Gaps = 1/47 (2%)

Query  1052  HAADGGQTPLYLACKN-GNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
             H +D G+TPL LA +  G+ E I+ L   G +   +  DG T +H A
Sbjct  208   HDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKA  254


>gi|27734215|sp|Q9H9E1|ANRA2_HUMAN  Ankyrin repeat family A protein 2 (RFXANK-like 2)
Length=313

 Score = 73.6 bits (179),  Expect = 8e-13
 Identities = 44/149 (29%), Positives = 76/149 (51%), Gaps = 1/149 (0%)

Query  953   PLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS  1012
             PL      + Q AAQG +  L+  + +E + IN++ E+G + L  AA +G    V  LL 
Sbjct  145   PLLANSLSVHQLAAQGEMLYLATRIEQENV-INHTDEEGFTPLMWAAAHGQIAVVEFLLQ  203

Query  1013  AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKEC  1072
               A      K   + L  A ++G+ + V++L+    ++N     G TPL  A    + +C
Sbjct  204   NGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKC  263

Query  1073  IKLLLEAGTNRSVKTTDGWTPVHAAVDTG  1101
             +K+LLE+G + +++T  G+  +  AV  G
Sbjct  264   VKMLLESGADPTIETDSGYNSMDLAVALG  292


 Score = 62.0 bits (149),  Expect = 2e-09
 Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 0/117 (0%)

Query  994   ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHA  1053
             +++  A  G    +   +  E  +N  D+ GFTPL  AAA G    VE L+   A+    
Sbjct  152   SVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLL  211

Query  1054  ADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
               G ++ L LAC  G  + +K+LL+ G + +    +G TP+  AV   +V  +K+L+
Sbjct  212   GKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLL  268


 Score = 43.5 bits (101),  Expect = 9e-04
 Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 9/157 (5%)

Query  893   LNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPA  952
             ++Q A     L + T I   + IN        P     L+  A+    ++   L+  G  
Sbjct  153   VHQLAAQGEMLYLATRIEQENVINHTDEEGFTP-----LMWAAAHGQIAVVEFLLQNGAD  207

Query  953   PLA---GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRL  1009
             P     GR + L  A ++G   ++ MLL + G+D+N    +G + L  A    H  CV++
Sbjct  208   PQLLGKGRESALSLACSKGYTDIVKMLL-DCGVDVNEYDWNGGTPLLYAVHGNHVKCVKM  266

Query  1010  LLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISY  1046
             LL + A       +G+  +  A A G+    +++ S+
Sbjct  267   LLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH  303


>gi|83305683|sp|Q68DC2|SAMD6_HUMAN  Sterile alpha motif domain-containing protein 6 (Ankyrin repeat 
domain-containing protein 14)
Length=871

 Score = 73.2 bits (178),  Expect = 1e-12
 Identities = 59/176 (33%), Positives = 85/176 (48%), Gaps = 24/176 (13%)

Query  949   GGPAPL-----AGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGH  1003
             G P P+     AG  T LQ AAA G+  L+  LL   G  +N     G SAL  AA+ GH
Sbjct  66    GAPVPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRR-GASVNSRNHYGWSALMQAARFGH  123

Query  1004  TDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQ-----  1058
                  LLL   A VNA ++ G + L  A+  GH   V+LL+   A ++H    G+     
Sbjct  124   VSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLG  183

Query  1059  ---------TPLYLACKNGNKECIKLLLEAGT--NRSVKTTDGWTPVHAAVDTGNV  1103
                      T L  A ++G++  ++LL+E G   N + +T  GW+P+  A  TG +
Sbjct  184   GSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTV-GWSPLMLAALTGRL  238


 Score = 64.3 bits (155),  Expect = 5e-10
 Identities = 74/255 (29%), Positives = 100/255 (39%), Gaps = 41/255 (16%)

Query  870   PAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASD  929
             PAG  V+    +  GA  A  P      CSD +       A      P+     R GAS 
Sbjct  49    PAGAEVAGPGAAAAGAVGAPVP----VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASV  104

Query  930   SLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCE  989
             +      GWS                     L QAA  G+V++  +LL + G D+N    
Sbjct  105   NSR-NHYGWSA--------------------LMQAARFGHVSVAHLLL-DHGADVNAQNR  142

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG--------------FTPLCAAAAQG  1035
              G S L  A++ GH   V+LLL A A V+    +G               T L AA   G
Sbjct  143   LGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHG  202

Query  1036  HFECVELLISYDANINHAADG-GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPV  1094
             H   V LL+ + A+ NHAA   G +PL LA   G     + L+E G N    +    T  
Sbjct  203   HEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAF  262

Query  1095  HAAVDTGNVDSLKLL  1109
               A+D  + D +  L
Sbjct  263   EVALDCKHRDLVDYL  277


 Score = 52.8 bits (125),  Expect = 1e-06
 Identities = 49/190 (25%), Positives = 80/190 (42%), Gaps = 31/190 (16%)

Query  926   GASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQG----NVTLLSMLLNEEG  981
             GA  +      GWSP +         A L GR  + QQ   +G    ++++L     E  
Sbjct  214   GADPNHAARTVGWSPLML--------AALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVA  265

Query  982   LDINYSC-----------------EDGHSALYSAAKNGHTDCVRLLLSAE-AQVNAADKN  1023
             LD  +                   E     ++ A K G+   V+ +   + + VN  + +
Sbjct  266   LDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGD  325

Query  1024  GFTPLCAAAAQGHFECVELLISYDANINHAAD-GGQTPLYLACKNGNKECIKLLLEAGTN  1082
             G TPL  AA  G    V+LL+   A+++      G T L  A  +GNKE +K LL  G +
Sbjct  326   GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGAD  385

Query  1083  RSVKTTDGWT  1092
              +++  +G+T
Sbjct  386   VTLRAKNGYT  395


 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 0/100 (0%)

Query  1011  LSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNK  1070
             + A   V+ +D+ G T L  AAA GH   V  L+   A++N     G + L  A + G+ 
Sbjct  65    VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHV  124

Query  1071  ECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                 LLL+ G + + +   G + +  A   G++  +KLL+
Sbjct  125   SVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLL  164


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 28/121 (23%), Positives = 47/121 (38%), Gaps = 3/121 (2%)

Query  995   LYSAAKNGHTDCVRLLL---SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANIN  1051
             L  A   G T+  R LL   +AE     A+         A   G        +     ++
Sbjct  13    LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD  72

Query  1052  HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY  1111
              + + G T L  A   G++  ++ LL  G + + +   GW+ +  A   G+V    LL+ 
Sbjct  73    CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD  132

Query  1112  H  1112
             H
Sbjct  133   H  133


>gi|29839757|sp|Q9H765|ASB8_HUMAN  Ankyrin repeat and SOCS box protein 8 (ASB-8)
Length=288

 Score = 72.4 bits (176),  Expect = 2e-12
 Identities = 48/131 (36%), Positives = 67/131 (51%), Gaps = 4/131 (3%)

Query  981   GLDINYSCEDGH-SALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFEC  1039
             G D+N  C  G    L+ A      DCV LLL   A+VNA D    T L  AA +    C
Sbjct  44    GADVN--CTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-AC  100

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVD  1099
             VE+L+ Y AN N       TPL+ A    N EC++ LLE+G + +    +  TP+  A  
Sbjct  101   VEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAM  160

Query  1100  TGNVDSLKLLM  1110
              GN++S+ +L+
Sbjct  161   KGNLESVSILL  171


 Score = 65.1 bits (157),  Expect = 3e-10
 Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 1/123 (0%)

Query  976   LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG  1035
             LL E+G ++N       +AL+ AA+     CV +LL   A  NA D N  TPL  AA + 
Sbjct  71    LLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKN  129

Query  1036  HFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH  1095
             + ECV  L+   A++N       TPL  A   GN E + +LL+ G    V    G TP+ 
Sbjct  130   NAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPIS  189

Query  1096  AAV  1098
               V
Sbjct  190   RLV  192


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 27/78 (34%), Positives = 37/78 (47%), Gaps = 5/78 (6%)

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW--TPVHAA  1097
             VE LI   A++N    G   PL+ AC   + +C++LLLE G    V   DG+  T +H A
Sbjct  37    VEDLIRGGADVN-CTHGTLKPLHCACMVSDADCVELLLEKGA--EVNALDGYNRTALHYA  93

Query  1098  VDTGNVDSLKLLMYHRIP  1115
              +        LL Y   P
Sbjct  94    AEKDEACVEVLLEYGANP  111


>gi|56749685|sp|O75762|TRPA1_HUMAN  Transient receptor potential cation channel subfamily A member 
1 (Ankyrin-like with transmembrane domains protein 1) (Transformation 
sensitive-protein p120)
Length=1119

 Score = 72.4 bits (176),  Expect = 2e-12
 Identities = 46/155 (29%), Positives = 82/155 (52%), Gaps = 9/155 (5%)

Query  965   AAQG-NVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN  1023
             A QG N  ++ +LL    +D+N   E+G++A+  A    +++ +++LL+  A+   ++K 
Sbjct  138   AVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLNKGAKPCKSNKW  197

Query  1024  GFTPLCAAAAQGHFECVELLI--------SYDANINHAADGGQTPLYLACKNGNKECIKL  1075
             G  P+  AA  G  EC+E+++        S   +IN   +G  TPL+LA +NG+ E IK+
Sbjct  198   GCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKM  257

Query  1076  LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              L+ G           T +H A   G  + +KL++
Sbjct  258   CLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMI  292


 Score = 58.5 bits (140),  Expect = 3e-08
 Identities = 61/258 (23%), Positives = 102/258 (39%), Gaps = 44/258 (17%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA  1015
             G+ T L  A   G++ ++ M L + G  I+   +   +A++ AA  G T+ V+L++S+ +
Sbjct  238   GKATPLHLAVQNGDLEMIKMCL-DNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYS  296

Query  1016  Q----VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKE  1071
                  VN  D    T L  A+   H E  + LIS  A+IN     G++PL LA  + +  
Sbjct  297   GSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWN  356

Query  1072  CIKLLLEAGTNRSVK--------------------------------------TTDGWTP  1093
              + LLL  G    +K                                        DG TP
Sbjct  357   IVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTP  416

Query  1094  VHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPADLI  1153
             +H A   G   S+  L+   +  H  S +++          G   + + + + +    L+
Sbjct  417   LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASY-GRINTCQRLLQDISDTRLL  475

Query  1154  NHANREGWTAAHIAASKG  1171
             N  +  G T  H+AA  G
Sbjct  476   NEGDLHGMTPLHLAAKNG  493


 Score = 58.2 bits (139),  Expect = 3e-08
 Identities = 40/124 (32%), Positives = 64/124 (51%), Gaps = 4/124 (3%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFE-CVELL--ISY  1046
             DG + L+ A + G    V  LL     +++  K+  +PL  AA+ G    C  LL  IS 
Sbjct  412   DGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISD  471

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL  1106
                +N     G TPL+LA KNG+ + ++LLL+ G    +   +GWT +H A   G   ++
Sbjct  472   TRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTM  530

Query  1107  KLLM  1110
             K+++
Sbjct  531   KVIL  534


 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 29/86 (33%), Positives = 48/86 (55%), Gaps = 4/86 (4%)

Query  1031  AAAQGHFECVELLISYDANI---NHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT  1087
             AAA+G  E +E  I+ D+++   +   D G TPL+ A +    E +K LL  G N +++ 
Sbjct  70    AAAEGQIELMEK-ITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRN  128

Query  1088  TDGWTPVHAAVDTGNVDSLKLLMYHR  1113
              +   P+H AV   N + +K+L+ HR
Sbjct  129   FNMMAPLHIAVQGMNNEVMKVLLEHR  154


 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 42/161 (26%), Positives = 80/161 (49%), Gaps = 11/161 (6%)

Query  961   LQQAAAQGNVTLLSMLLN---EEG----LDINYSCEDGHSALYSAAKNGHTDCVRLLLSA  1013
             + QAA  G+   + ++L    E G    L IN+      + L+ A +NG  + +++ L  
Sbjct  202   IHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN  261

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLI-SYDANIN--HAADG-GQTPLYLACKNGN  1069
              AQ++  +K   T +  AA QG  E V+L+I SY  +++  +  DG  +T L+ A    +
Sbjct  262   GAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDH  321

Query  1070  KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              E    L+  G + +   ++G +P+  A  + + + + LL+
Sbjct  322   HELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLL  362


 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 59/246 (23%), Positives = 97/246 (39%), Gaps = 54/246 (21%)

Query  913   SSINPVSASSCRP-------GASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAA  965
             + I+PV    C         GA++ + +  S +S S+  +  + G        T+L +A+
Sbjct  263   AQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGC-----HETMLHRAS  317

Query  966   AQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK---  1022
                +  L   L++  G DIN    +G S L  A  +   + V LLLS  AQV+  D    
Sbjct  318   LFDHHELADYLISV-GADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGR  376

Query  1023  -----------------------------------NGFTPLCAAAAQGHFECVELLISYD  1047
                                                +G TPL  A  QG    V  L+ ++
Sbjct  377   NFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFN  436

Query  1048  ANINHAADGGQTPLYLACKNGN-KECIKLLLEAGTNRSVKTTD--GWTPVHAAVDTGNVD  1104
              +I+  +   ++PL+ A   G    C +LL +    R +   D  G TP+H A   G+  
Sbjct  437   VSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDK  496

Query  1105  SLKLLM  1110
              ++LL+
Sbjct  497   VVQLLL  502


 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 36/120 (30%), Positives = 61/120 (50%), Gaps = 4/120 (3%)

Query  961   LQQAAAQGNVTLLSMLLNE--EGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             L  AA+ G +     LL +  +   +N     G + L+ AAKNGH   V+LLL   A + 
Sbjct  450   LHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LF  508

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAAD-GGQTPLYLACKNGNKECIKLLL  1077
              +D NG+T L  A+  G+ + +++++  +       D  G T L+ A + G+ + + LLL
Sbjct  509   LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLL  568


 Score = 47.4 bits (111),  Expect = 6e-05
 Identities = 38/128 (29%), Positives = 66/128 (51%), Gaps = 4/128 (3%)

Query  987   SCEDGHSA-LYSAAKNGHTDCVRLLL--SAEAQVNAADKNGFTPLCAAAAQGHFECVELL  1043
             +C+D  +  L+ AA  G  + +  +   S+   ++  D  G TPL  A  +   E V+ L
Sbjct  58    TCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFL  117

Query  1044  ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGT-NRSVKTTDGWTPVHAAVDTGN  1102
             +S  AN N        PL++A +  N E +K+LLE  T + +++  +G T V  A  T N
Sbjct  118   LSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNN  177

Query  1103  VDSLKLLM  1110
              ++L++L+
Sbjct  178   SEALQILL  185


 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 23/64 (35%), Positives = 32/64 (50%), Gaps = 10/64 (15%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSC-----EDGHSALYSAAKNGHTDCVRLLLSA  1013
             T L  A+  G    + ++L     D N  C     EDG++AL+ AA+ GH   V LLLS 
Sbjct  516   TALHHASMGGYTQTMKVIL-----DTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSH  570

Query  1014  EAQV  1017
              A +
Sbjct  571   NADI  574


>gi|20140805|sp|Q9H2K2|TNKS2_HUMAN  Tankyrase 2 (TANK2) (Tankyrase II) (TNKS-2) (TRF1-interacting 
ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) 
(Tankyrase-related protein)
Length=1166

 Score = 72.0 bits (175),  Expect = 2e-12
 Identities = 43/120 (35%), Positives = 65/120 (54%), Gaps = 3/120 (2%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNG--FTPLCAAAAQGHFECVELLISYDANINH  1052
             L+ A +NG  + V+ L++ E +VN+ D  G   TPL  AA  G  + VE L+   AN+  
Sbjct  28    LFEACRNGDVERVKRLVTPE-KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA  86

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
               DGG  PL+ AC  G+ E + LLL  G + + +    +TP+H A   G +D   +L+ H
Sbjct  87    RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH  146


 Score = 71.2 bits (173),  Expect = 4e-12
 Identities = 51/149 (34%), Positives = 71/149 (47%), Gaps = 1/149 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G+V  +  L   + ++         + L+ AA       V  LL   A V+A 
Sbjct  496   LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK  555

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             DK G  PL  A + GH+E  ELL+ + A +N A     TPL+ A   G  E  KLLL+ G
Sbjct  556   DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG  615

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
              + + K  DG TP+    D G+ D   LL
Sbjct  616   ADPTKKNRDGNTPLDLVKD-GDTDIQDLL  643


 Score = 67.8 bits (164),  Expect = 4e-11
 Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 12/159 (7%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDG---HSA-LYSAAKNGHTDCVRLLLSAEAQ  1016
             L  AA +G +  +  L + +    N +C D    HS  L+ AA   + +    LL   A 
Sbjct  649   LLDAAKKGCLARVKKLSSPD----NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGAD  704

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             VNA DK G  PL  AA+ GH +   LLI Y+A +N       TPL+ A + G  +   LL
Sbjct  705   VNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALL  764

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP  1115
             L  G + ++K  +G TP    +D  + D +  L+   +P
Sbjct  765   LAHGADPTLKNQEGQTP----LDLVSADDVSALLTAAMP  799


 Score = 63.5 bits (153),  Expect = 8e-10
 Identities = 49/155 (31%), Positives = 71/155 (45%), Gaps = 6/155 (3%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +A   G+V  +  L+  E ++   +     + L+ AA  G  D V  LL   A V A 
Sbjct  28    LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR  87

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D  G  PL  A + GH E V LL+ + A+ N   +   TPL+ A   G  +   +LL+ G
Sbjct  88    DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG  147

Query  1081  TNRSVKTTDGWT------PVHAAVDTGNVDSLKLL  1109
                +++ TDG T      P   AV TG     +LL
Sbjct  148   AEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELL  182


 Score = 63.5 bits (153),  Expect = 8e-10
 Identities = 41/105 (39%), Positives = 55/105 (52%), Gaps = 1/105 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA   N+ +   LL + G D+N   + G   L++AA  GH D   LL+   A VN
Sbjct  681   TPLHLAAGYNNLEVAEYLL-QHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVN  739

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL  1063
             A DK  FTPL  AA +G  +   LL+++ A+       GQTPL L
Sbjct  740   ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL  784


 Score = 63.2 bits (152),  Expect = 1e-09
 Identities = 53/176 (30%), Positives = 81/176 (46%), Gaps = 24/176 (13%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA    V+++  LL + G D++   + G   L++A   GH +   LL+   A VN
Sbjct  528   TPLHFAAGYNRVSVVEYLL-QHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN  586

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL--  1076
              AD   FTPL  AAA+G +E  +LL+ + A+       G TPL L  K+G+ +   LL  
Sbjct  587   VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLRG  645

Query  1077  ------------------LEAGTNRSVKTTDG--WTPVHAAVDTGNVDSLKLLMYH  1112
                               L +  N + + T G   TP+H A    N++  + L+ H
Sbjct  646   DAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH  701


 Score = 62.0 bits (149),  Expect = 2e-09
 Identities = 63/230 (27%), Positives = 96/230 (41%), Gaps = 32/230 (13%)

Query  976   LLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQG  1035
             LL  +G +IN   ++  + L+ A++  H D V +++  EA+VNA D  G T L  AA  G
Sbjct  385   LLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG  444

Query  1036  HFECVELLISYDANINHAADGGQTPLYLACKN-----------GNKECIKLLLEAGTNRS  1084
             H +   LL+SY  + N  +  G T L +  +N           GN E  + LLEA     
Sbjct  445   HLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGD  504

Query  1085  VKTTDGW----------------TPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeeses  1128
             V+T                    TP+H A     V  ++ L+ H    H           
Sbjct  505   VETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLH  564

Query  1129  sVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKG-FKDCNL  1177
             +     G  E  E + K      ++N A+   +T  H AA+KG ++ C L
Sbjct  565   NACSY-GHYEVAELLVK---HGAVVNVADLWKFTPLHEAAAKGKYEICKL  610


 Score = 55.5 bits (132),  Expect = 2e-07
 Identities = 54/186 (29%), Positives = 80/186 (43%), Gaps = 25/186 (13%)

Query  955   AGRP-TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSA  1013
             AGR  T L  AA  G   ++  LL + G ++    + G   L++A   GH + V LLL  
Sbjct  55    AGRKSTPLHFAAGFGRKDVVEYLL-QNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH  113

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLA---------  1064
              A  NA D   +TPL  AA +G  +   +L+ + A        G+T L LA         
Sbjct  114   GADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLT  173

Query  1065  -----------CKNGNKECIKLLLEAGTNRSVKTTDGW--TPVHAAVDTGNVDSLKLLMY  1111
                         ++GN+E +  LL    N +   +DG   TP+H A     V  ++LL+ 
Sbjct  174   GEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ  232

Query  1112  HRIPAH  1117
             H    H
Sbjct  233   HGADVH  238


 Score = 55.1 bits (131),  Expect = 3e-07
 Identities = 47/175 (26%), Positives = 79/175 (45%), Gaps = 26/175 (14%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSAL--------------------YSA  998
             T L +AA +G + +  +LL + G +      DG +AL                      +
Sbjct  126   TPLHEAAIKGKIDVCIVLL-QHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLES  184

Query  999   AKNGHTDCVRLLLSA-EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGG  1057
             A++G+ + +  LL+      +A+D    TPL  AA     + V+LL+ + A+++    G 
Sbjct  185   ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD  244

Query  1058  QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW--TPVHAAVDTGNVDSLKLLM  1110
               PL+ AC  G+ E  +LL++ G    V   D W  TP+H A     V+   LL+
Sbjct  245   LVPLHNACSYGHYEVTELLVKHGA--CVNAMDLWQFTPLHEAASKNRVEVCSLLL  297


 Score = 48.9 bits (115),  Expect = 2e-05
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query  957   RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ  1016
             + T L  AA    V ++ +LL + G D++   +     L++A   GH +   LL+   A 
Sbjct  211   KSTPLHLAAGYNRVKIVQLLL-QHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC  269

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             VNA D   FTPL  AA++   E   LL+SY A+
Sbjct  270   VNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD  302


 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 42/176 (23%), Positives = 77/176 (43%), Gaps = 25/176 (14%)

Query  959   TLLQQAAAQGNVTLLSMLL------------NEEGLDINYSCE---------DGHSALYS  997
             T L +AA++  V + S+LL            N+  +D+  + +          GHS L  
Sbjct  279   TPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLL-Q  337

Query  998   AAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGH---FECVELLISYDANINHAA  1054
             AA+      ++  LS E       +   T L  AAA  +    +  ELL+   ANIN   
Sbjct  338   AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT  397

Query  1055  DGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                 TPL++A +  + + ++++++     +     G T +H A   G++ + +LL+
Sbjct  398   KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL  453


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 14/43 (32%), Positives = 26/43 (60%), Gaps = 0/43 (0%)

Query  1070  KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             K+  +LLL  G N + KT +  TP+H A +  + D +++++ H
Sbjct  380   KQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKH  422


>gi|6093962|sp|O14593|RFXK_HUMAN  DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) 
(Ankyrin repeat family A protein 1)
Length=260

 Score = 70.9 bits (172),  Expect = 5e-12
 Identities = 63/179 (35%), Positives = 84/179 (46%), Gaps = 14/179 (7%)

Query  901   SSLVIPTTIAFCSSINPVSASSCRPGASDSLLV---TASGWSPSLTPLLMSGGPAPLAGR  957
             SSL   TT+      N VSA    P   DSL +    A G    L   L  G    L  +
Sbjct  65    SSLKHSTTLTNRQRGNEVSAL---PATLDSLSIHQLAAQGELDQLKEHLRKGDN--LVNK  119

Query  958   P-----TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS  1012
             P     T L  A+A G +  +  LL E G D +   ++  SAL  A+  G+TD V LLL 
Sbjct  120   PDERGFTPLIWASAFGEIETVRFLL-EWGADPHILAKERESALSLASTGGYTDIVGLLLE  178

Query  1013  AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKE  1071
              +  +N  D NG TPL  A    H +CVE L++  A++   AD G TP+ LA   G ++
Sbjct  179   RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK  237


 Score = 62.8 bits (151),  Expect = 1e-09
 Identities = 43/141 (30%), Positives = 67/141 (47%), Gaps = 0/141 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             + Q AAQG +  L   L +    +N   E G + L  A+  G  + VR LL   A  +  
Sbjct  94    IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL  153

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
              K   + L  A+  G+ + V LL+  D +IN     G TPL  A +  + +C++ LL  G
Sbjct  154   AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG  213

Query  1081  TNRSVKTTDGWTPVHAAVDTG  1101
              + + +   G+TP+  AV  G
Sbjct  214   ADLTTEADSGYTPMDLAVALG  234


 Score = 51.2 bits (121),  Expect = 4e-06
 Identities = 35/118 (29%), Positives = 60/118 (50%), Gaps = 1/118 (0%)

Query  994   ALYSAAKNGHTDCVRL-LLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH  1052
             +++  A  G  D ++  L   +  VN  D+ GFTPL  A+A G  E V  L+ + A+ + 
Sbjct  93    SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI  152

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              A   ++ L LA   G  + + LLLE   + ++   +G TP+  AV   +V  ++ L+
Sbjct  153   LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL  210


>gi|50400336|sp|Q6UB99|ANR11_HUMAN  Ankyrin repeat domain protein 11 (Ankyrin repeat-containing cofactor 
1)
Length=2664

 Score = 69.3 bits (168),  Expect = 2e-11
 Identities = 45/126 (35%), Positives = 68/126 (53%), Gaps = 4/126 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L +AA +G+   +  L++E G D+N     G +AL+ A   G+ D  + LL+A A+VN
Sbjct  171   TRLHRAAIRGDARRIKELISE-GADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVN  229

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                 +  TPL  AA  GH++ V+LL+ Y  N   +   G+TPL +A    +   + LLL 
Sbjct  230   TKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA---NSPTMVNLLLG  286

Query  1079  AGTNRS  1084
              GT  S
Sbjct  287   KGTYTS  292


 Score = 61.6 bits (148),  Expect = 3e-09
 Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 0/114 (0%)

Query  984   INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL  1043
             +N   E G + L+ AA  G    ++ L+S  A VN  D  G+T L  A  +G+++  + L
Sbjct  162   VNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQL  221

Query  1044  ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
             ++  A +N       TPL+ A  NG+ + +KLLL  G N       G TP+  A
Sbjct  222   LAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVA  275


 Score = 55.8 bits (133),  Expect = 2e-07
 Identities = 41/141 (29%), Positives = 64/141 (45%), Gaps = 3/141 (2%)

Query  970   VTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLC  1029
             V LL  +  EE  +        H +  +  + G  +        + +VN  ++ G T L 
Sbjct  118   VALLMQMTAEESANSPVDTTPKHPSQSTVCQKGTPNSAS---KTKDKVNKRNERGETRLH  174

Query  1030  AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD  1089
              AA +G    ++ LIS  A++N     G T L+ AC  G  +  K LL AG   + K  D
Sbjct  175   RAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAGAEVNTKGLD  234

Query  1090  GWTPVHAAVDTGNVDSLKLLM  1110
               TP+H A + G+   +KLL+
Sbjct  235   DDTPLHDAANNGHYKVVKLLL  255


>gi|9973397|sp|Q13418|ILK1_HUMAN  Integrin-linked protein kinase 1 (ILK-1) (59 kDa serine/threonine-protein 
kinase) (p59ILK)
Length=452

 Score = 68.9 bits (167),  Expect = 2e-11
 Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 0/131 (0%)

Query  967   QGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFT  1026
             +GN   + + L+    D+N   + G S L+ A + G +  V +L+   A++N  ++   T
Sbjct  10    EGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDT  69

Query  1027  PLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVK  1086
             PL  AA+ GH + V+ L+ Y A+IN   + G  PL+ AC  G  +  + L+  G   S+ 
Sbjct  70    PLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSIC  129

Query  1087  TTDGWTPVHAA  1097
                G  PV  A
Sbjct  130   NKYGEMPVDKA  140


 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 2/80 (2%)

Query  1034  QGHFECVELLISYDAN-INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT  1092
             +G+   V L +    N +N   D G +PL+ AC+ G    +++L+  G   +V      T
Sbjct  10    EGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDT  69

Query  1093  PVHAAVDTGNVDSL-KLLMY  1111
             P+H A   G+ D + KLL Y
Sbjct  70    PLHLAASHGHRDIVQKLLQY  89


>gi|9973390|sp|P57043|ILK2_HUMAN  Integrin-linked protein kinase 2 (ILK-2)
Length=452

 Score = 68.9 bits (167),  Expect = 2e-11
 Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 0/131 (0%)

Query  967   QGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFT  1026
             +GN   + + L+    D+N   + G S L+ A + G +  V +L+   A++N  ++   T
Sbjct  10    EGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDT  69

Query  1027  PLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVK  1086
             PL  AA+ GH + V+ L+ Y A+IN   + G  PL+ AC  G  +  + L+  G   S+ 
Sbjct  70    PLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSIC  129

Query  1087  TTDGWTPVHAA  1097
                G  PV  A
Sbjct  130   NKYGEMPVDKA  140


 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 2/80 (2%)

Query  1034  QGHFECVELLISYDAN-INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT  1092
             +G+   V L +    N +N   D G +PL+ AC+ G    +++L+  G   +V      T
Sbjct  10    EGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDT  69

Query  1093  PVHAAVDTGNVDSL-KLLMY  1111
             P+H A   G+ D + KLL Y
Sbjct  70    PLHLAASHGHRDIVQKLLQY  89


>gi|20531998|sp|Q96NS5|ASB16_HUMAN  Ankyrin repeat and SOCS box protein 16 (ASB-16)
Length=453

 Score = 68.6 bits (166),  Expect = 3e-11
 Identities = 38/108 (35%), Positives = 60/108 (55%), Gaps = 1/108 (0%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI  1050
             G +AL+ A      DCVRLLL+  A+ N   + G TPL         +C +LL+   A +
Sbjct  143   GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV  202

Query  1051  NHAA-DGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
             N AA +  +TPL++A   G ++ + L LE G +  ++T+ G T ++AA
Sbjct  203   NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNAA  250


 Score = 59.3 bits (142),  Expect = 2e-08
 Identities = 55/190 (28%), Positives = 85/190 (44%), Gaps = 13/190 (6%)

Query  932   LVTASGWSPSLTPLLMSGGP--APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCE  989
             + TA G++     L+  G    A + GR  L  +A A+     + +LL   G   N   E
Sbjct  117   IATARGYTDCARHLIRQGAELDARVGGRAAL-HEACARAQFDCVRLLLTF-GAKANVLTE  174

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVN-AADKNGFTPLCAAAAQGHFECVELLISYDA  1048
             +G + L+         C +LLL A A VN AA ++  TPL  AAA+G  + V L + + A
Sbjct  175   EGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGA  234

Query  1049  NINHAADGGQTPLYLACKNG--------NKECIKLLLEAGTNRSVKTTDGWTPVHAAVDT  1100
             ++      G+T L  AC           ++   + LLEAG +         TP+H A  +
Sbjct  235   DVGLRTSQGETALNAACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACAS  294

Query  1101  GNVDSLKLLM  1110
             G     +LL+
Sbjct  295   GCGGLAELLL  304


 Score = 54.3 bits (129),  Expect = 5e-07
 Identities = 29/84 (34%), Positives = 45/84 (53%), Gaps = 1/84 (1%)

Query  1027  PLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVK  1086
             PL  A A+G+ +C   LI   A ++ A  GG+  L+ AC     +C++LLL  G   +V 
Sbjct  114   PLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGAKANVL  172

Query  1087  TTDGWTPVHAAVDTGNVDSLKLLM  1110
             T +G TP+H      ++   KLL+
Sbjct  173   TEEGTTPLHLCTIPESLQCAKLLL  196


 Score = 45.8 bits (107),  Expect = 2e-04
 Identities = 41/128 (32%), Positives = 53/128 (41%), Gaps = 12/128 (9%)

Query  945   LLMSGGPAPLAG---RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKN  1001
             LL +G    LA    + T L  AAA+G    +++ L E G D+      G +AL +A   
Sbjct  195   LLEAGATVNLAAGESQETPLHVAAARGLEQHVALYL-EHGADVGLRTSQGETALNAACAG  253

Query  1002  G--------HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHA  1053
                      H    R LL A A   AA +   TPL  A A G     ELL+ Y A     
Sbjct  254   AEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACASGCGGLAELLLRYGARAEVP  313

Query  1054  ADGGQTPL  1061
                G TP+
Sbjct  314   NGAGHTPM  321


>gi|50400335|sp|Q6UB98|ANR12_HUMAN  Ankyrin repeat domain protein 12 (Ankyrin repeat-containing cofactor 
2) (GAC-1 protein)
Length=2062

 Score = 68.6 bits (166),  Expect = 3e-11
 Identities = 42/132 (31%), Positives = 67/132 (50%), Gaps = 4/132 (3%)

Query  984   INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL  1043
             +N   E G + L+ AA  G    V+ L+S  A VN  D  G+TPL  A   G+++  ++L
Sbjct  178   VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL  237

Query  1044  ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNV  1103
             I+  A++N       TPL+ +  +G+++ +KLLL  G N       G  P    VD    
Sbjct  238   IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERP----VDVAET  293

Query  1104  DSLKLLMYHRIP  1115
             + L+LL+   +P
Sbjct  294   EELELLLKREVP  305


 Score = 66.2 bits (160),  Expect = 1e-10
 Identities = 37/97 (38%), Positives = 57/97 (58%), Gaps = 0/97 (0%)

Query  1016  QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKL  1075
             +VN  ++ G TPL  AA +G  + V+ LIS  AN+N     G TPL+ AC  G  +  K+
Sbjct  177   KVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKI  236

Query  1076  LLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             L+ AG + + +  D  TP+H +  +G+ D +KLL+ H
Sbjct  237   LIAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRH  273


 Score = 51.6 bits (122),  Expect = 3e-06
 Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 5/120 (4%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  AA +G+V  +  L++  G ++N     G + L+ A   G+ D  ++L++A A VN
Sbjct  187   TPLHMAAIRGDVKQVKELISL-GANVNVKDFAGWTPLHEACNVGYYDVAKILIAAGADVN  245

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                 +  TPL  +A+ GH + V+LL+ +  N   A   G+ P+ +A      E ++LLL+
Sbjct  246   TQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVA----ETEELELLLK  301


>gi|21759004|sp|Q9GZV1|ANKR2_HUMAN  Ankyrin repeat domain protein 2 (Skeletal muscle ankyrin repeat 
protein) (hArpp)
Length=333

 Score = 67.8 bits (164),  Expect = 4e-11
 Identities = 52/165 (31%), Positives = 74/165 (44%), Gaps = 3/165 (1%)

Query  931   LLVTASGWSPSLTPLLMSGGPAPLAG--RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSC  988
             L     G    +   L  GG A      R T L +A+ +G++ +L  LL + G  +++  
Sbjct  126   LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLL-DNGATVDFQD  184

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDA  1048
                 +A++ A + GH + V+LL S  A  N  DK   TPL  A   G  E VE  +S   
Sbjct  185   RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL  244

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP  1093
              IN     G T L+ A +    + IKLLL  G +   K   G TP
Sbjct  245   EINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP  289


 Score = 62.8 bits (151),  Expect = 1e-09
 Identities = 43/150 (28%), Positives = 73/150 (48%), Gaps = 1/150 (0%)

Query  963   QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK  1022
             +AA +G + ++   L + G   +   +   +AL+ A+  GH + +  LL   A V+  D+
Sbjct  127   KAAVEGKMKVIEKFLADGG-SADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR  185

Query  1023  NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN  1082
                T +  A   GH E V+LL S+ A+ N       TPL++A + G  E ++  L  G  
Sbjct  186   LDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLE  245

Query  1083  RSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
              + +  +G T +H AV       +KLL+ H
Sbjct  246   INARDREGDTALHDAVRLNRYKIIKLLLLH  275


>gi|20139103|sp|Q99466|NOTC4_HUMAN  Neurogenic locus notch homolog protein 4 precursor (Notch 4) 
(hNotch4) [Contains: Notch 4 extracellular truncation; Notch 
4 intracellular domain]
Length=2003

 Score = 67.4 bits (163),  Expect = 6e-11
 Identities = 60/189 (31%), Positives = 86/189 (45%), Gaps = 6/189 (3%)

Query  926   GASDSLLVTASGWS-PSLTPLLMSGGPAP----LAGRPTLLQQAAAQGNVTLLSMLLNEE  980
             G  ++ L  A+ +S P+    L+  G  P     AGR T L  A A     +  +LL   
Sbjct  1632  GTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGR-TPLHAAVAADAREVCQLLLRSR  1690

Query  981   GLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECV  1040
                ++   EDG + L  AA+    D V  L++A+A V A DK G T L  AAA  +    
Sbjct  1691  QTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAA  1750

Query  1041  ELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDT  1100
               L+   A+ +   +  QTPL+LA + G  E  +LLL  G  R ++   G  P   A   
Sbjct  1751  RSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQR  1810

Query  1101  GNVDSLKLL  1109
              + D L LL
Sbjct  1811  NHWDLLTLL  1819


 Score = 60.1 bits (144),  Expect = 9e-09
 Identities = 54/178 (30%), Positives = 79/178 (44%), Gaps = 11/178 (6%)

Query  938   WSPSLTPLLMSGGPAPLAGR----PTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHS  993
             W P     L+ GG  P A       T L  AA     T    LL E G + N     G +
Sbjct  1616  WEP-----LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLL-EAGANPNQPDRAGRT  1669

Query  994   ALYSA-AKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH  1052
              L++A A +    C  LL S +  V+A  ++G TPL  AA     + VE LI+  A++  
Sbjct  1670  PLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGA  1729

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                 G+T L+ A    N    + LL+AG ++  +     TP+  A   G V+  +LL+
Sbjct  1730  RDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLL  1787


 Score = 41.6 bits (96),  Expect = 0.003
 Identities = 23/62 (37%), Positives = 32/62 (51%), Gaps = 0/62 (0%)

Query  1052  HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMY  1111
             H    G+TPL+LA +       + LLEAG N +     G TP+HAAV     +  +LL+ 
Sbjct  1629  HTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLR  1688

Query  1112  HR  1113
              R
Sbjct  1689  SR  1690


>gi|38372887|sp|Q9H672|ASB7_HUMAN  Ankyrin repeat and SOCS box protein 7 (ASB-7)
Length=318

 Score = 67.0 bits (162),  Expect = 8e-11
 Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 5/132 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYS-CEDGHSALYSAAKNGHTDCVRLLLSAEAQ-  1016
             TLL  +AA+G    + + L E G D        G +AL+ AA +G     RL+L +E + 
Sbjct  49    TLLHFSAARGKERCVRVFL-EHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRS  107

Query  1017  --VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIK  1074
               +NA   +G+TPL  AA  G    V LL+ + A ++  +D G TPL LA       C+K
Sbjct  108   DIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVK  167

Query  1075  LLLEAGTNRSVK  1086
             +LL+   N  ++
Sbjct  168   ILLDHNANIDIQ  179


 Score = 65.5 bits (158),  Expect = 2e-10
 Identities = 49/178 (27%), Positives = 77/178 (43%), Gaps = 33/178 (18%)

Query  954   LAGRPTLLQQAAAQGNVTLLSMLLNEEGLD--INYSCEDGHSALYSAAKNGHTDCVRLLL  1011
             L G  T L  AA  G   +  ++L  E     IN    DG + L+ AA  G    VRLLL
Sbjct  78    LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL  137

Query  1012  SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI---------------NHA---  1053
               +A+V+     G TPL  A  +    CV++L+ ++ANI               NH+   
Sbjct  138   EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR  197

Query  1054  -------------ADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
                           + GQTPL+L+    +  C ++L   G + + +  +G TP+  ++
Sbjct  198   MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSI  255


 Score = 59.7 bits (143),  Expect = 1e-08
 Identities = 46/156 (29%), Positives = 71/156 (45%), Gaps = 5/156 (3%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             +Q A A G+V  +  +L E+G   N    +G + L+ +A  G   CVR+ L   A     
Sbjct  18    IQAAVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVK  76

Query  1021  DK-NGFTPLCAAAAQGHFECVELLISYDAN---INHAADGGQTPLYLACKNGNKECIKLL  1076
             D   GFT L  AA  G      L++  +     IN  ++ G TPL++A   G    ++LL
Sbjct  77    DLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL  136

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             LE        +  G TP+  A+       +K+L+ H
Sbjct  137   LEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH  172


 Score = 40.4 bits (93),  Expect = 0.008
 Identities = 32/143 (22%), Positives = 54/143 (37%), Gaps = 35/143 (24%)

Query  1030  AAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTT-  1088
             AA A G    V  ++    + N     G T L+ +   G + C+++ LE G + +VK   
Sbjct  20    AAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI  79

Query  1089  DGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVV  1148
              G+T +H A   G     +L++                                  +   
Sbjct  80    GGFTALHYAAMHGRARIARLML----------------------------------ESEY  105

Query  1149  PADLINHANREGWTAAHIAASKG  1171
              +D+IN  + +GWT  H+AA  G
Sbjct  106   RSDIINAKSNDGWTPLHVAAHYG  128


>gi|114870|sp|P20749|BCL3_HUMAN  B-cell lymphoma 3-encoded protein (Bcl-3 protein)
Length=446

 Score = 65.9 bits (159),  Expect = 2e-10
 Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 7/175 (4%)

Query  940   PSLTPLLMSGGPAPLA---GRPTLLQQAAAQGNVTLLSMLLNEEG---LDINYSCEDGHS  993
             PS+  LL++ G +P+A      T    A    + T L  LL+      LD+     DG +
Sbjct  177   PSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLT  236

Query  994   ALYSAAKNGHTDCVRLLLSAEAQVNAAD-KNGFTPLCAAAAQGHFECVELLISYDANINH  1052
             AL+ A      + V+LLL   A ++A D K+G +PL  A        V+LL+ + AN+N 
Sbjct  237   ALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNA  296

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLK  1107
                 G + L+ A   G    ++ L+ +G + S+K     TP+  A     +D L+
Sbjct  297   QMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILR  351


 Score = 48.1 bits (113),  Expect = 4e-05
 Identities = 46/177 (25%), Positives = 76/177 (42%), Gaps = 13/177 (7%)

Query  942   LTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKN  1001
             L P    G P PL   PT L          L + +      D     EDG + L+ A   
Sbjct  83    LYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRAD-----EDGDTPLHIAVVQ  137

Query  1002  GHTDCVRLLLSAEAQ----VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGG  1057
             G+   V  L++   Q    ++  +    TPL  A        V LL++  A+       G
Sbjct  138   GNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHG  197

Query  1058  QTPLYLACKNGNKECIKLLLEAGT----NRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             QT  +LAC++ +  C++ LL++      +   +  DG T +H AV+T   ++++LL+
Sbjct  198   QTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLL  254


 Score = 47.0 bits (110),  Expect = 8e-05
 Identities = 36/126 (28%), Positives = 65/126 (51%), Gaps = 7/126 (5%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEA----QVNAADKNGFTPLCAAAAQGHFECVELLISY  1046
             G +A + A ++    C+R LL + A     + A + +G T L  A      E V+LL+  
Sbjct  197   GQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLER  256

Query  1047  DANINHAAD--GGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVD  1104
              A+I+ A D   G++PL  A +N +   ++LLL+ G N + +   G + +H+A   G + 
Sbjct  257   GADID-AVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLP  315

Query  1105  SLKLLM  1110
              ++ L+
Sbjct  316   LVRTLV  321


 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 5/110 (4%)

Query  1011  LSAE-AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG----GQTPLYLAC  1065
             LSA+ A    AD++G TPL  A  QG+   V  L++         D      QTPL+LA 
Sbjct  113   LSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAV  172

Query  1066  KNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP  1115
                    ++LL+ AG +       G T  H A +  +   L+ L+    P
Sbjct  173   ITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAP  222


>gi|13123980|sp|Q99728|BARD1_HUMAN  BRCA1-associated RING domain protein 1 (BARD-1)
Length=777

 Score = 65.9 bits (159),  Expect = 2e-10
 Identities = 42/119 (35%), Positives = 60/119 (50%), Gaps = 1/119 (0%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI  1050
             G + L+ A+  G    V  LL   +  N  D  G+TPL  A   GH + VELL+ + A +
Sbjct  428   GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALV  487

Query  1051  NHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             N       +PL+ A KNG+ + +KLLL  G +R+     G  PV    D  ++ SL LL
Sbjct  488   NTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVD-YTDDESMKSLLLL  545


 Score = 58.5 bits (140),  Expect = 3e-08
 Identities = 47/144 (32%), Positives = 66/144 (45%), Gaps = 5/144 (3%)

Query  922   SCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGR----PTLLQQAAAQGNVTLLSMLL  977
             S  PG   S L ++S      +P  M   P     R     TLL  A+ +G++  +  LL
Sbjct  389   SLSPGTPPSTLSSSSYRQVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLL  448

Query  978   NEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHF  1037
              + G D N     G + L+ A  +GH   V LLL  +A VN       +PL  AA  GH 
Sbjct  449   -QNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV  507

Query  1038  ECVELLISYDANINHAADGGQTPL  1061
             + V+LL+SY A+ N     G  P+
Sbjct  508   DIVKLLLSYGASRNAVNIFGLRPV  531


 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 30/90 (33%), Positives = 52/90 (57%), Gaps = 6/90 (6%)

Query  1024  GFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNR  1083
             G T L  A+ +G    VE L+   ++ N     G TPL+ AC +G+ + ++LLL+   ++
Sbjct  428   GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ---HK  484

Query  1084  SVKTTDGW---TPVHAAVDTGNVDSLKLLM  1110
             ++  T G+   +P+H A   G+VD +KLL+
Sbjct  485   ALVNTTGYQNDSPLHDAAKNGHVDIVKLLL  514


 Score = 46.2 bits (108),  Expect = 1e-04
 Identities = 24/74 (32%), Positives = 45/74 (60%), Gaps = 3/74 (4%)

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVD  1099
             ++LL +     NH    G+T L++A   G+   ++ LL+ G++ +VK   GWTP+H A +
Sbjct  414   MKLLPNMAVKRNHR---GETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACN  470

Query  1100  TGNVDSLKLLMYHR  1113
              G++  ++LL+ H+
Sbjct  471   HGHLKVVELLLQHK  484


>gi|55583954|sp|Q8N8V4|HARP_HUMAN  Harmonin-interacting ankyrin repeat-containing protein (Harp)
Length=460

 Score = 65.5 bits (158),  Expect = 2e-10
 Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 3/127 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T   QAA+   + LL         D+N S EDG +    AA +G+ + + ++ S     +
Sbjct  3     TRYHQAASDSYLELLKEATKR---DLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPD  59

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D  G TPL  AA+ GH  CV  L+++ ANI    +  QTPL  A      EC+ LL +
Sbjct  60    RCDIWGNTPLHFAASNGHAHCVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALLDK  119

Query  1079  AGTNRSV  1085
             A T +++
Sbjct  120   AATAQNI  126


 Score = 55.8 bits (133),  Expect = 2e-07
 Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 0/98 (0%)

Query  1012  SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKE  1071
             + +  +N +D++G TP   AA  G+ E +E++ S   + +     G TPL+ A  NG+  
Sbjct  20    ATKRDLNLSDEDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWGNTPLHFAASNGHAH  79

Query  1072  CIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             C+  L+  G N      D  TP+ AA      + + LL
Sbjct  80    CVSFLVNFGANIFALDNDLQTPLDAAASREQNECVALL  117


 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 21/80 (26%), Positives = 38/80 (47%), Gaps = 2/80 (2%)

Query  1031  AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG  1090
             AA+  + E ++     D N++   + G TP  LA  +GN E ++++   G +       G
Sbjct  8     AASDSYLELLKEATKRDLNLSD--EDGMTPTLLAAYHGNLEALEIICSRGGDPDRCDIWG  65

Query  1091  WTPVHAAVDTGNVDSLKLLM  1110
              TP+H A   G+   +  L+
Sbjct  66    NTPLHFAASNGHAHCVSFLV  85


>gi|62512181|sp|Q8WXK4|ASB12_HUMAN  Ankyrin repeat and SOCS box protein 12 (ASB-12)
Length=309

 Score = 64.7 bits (156),  Expect = 4e-10
 Identities = 44/140 (31%), Positives = 68/140 (48%), Gaps = 10/140 (7%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L+ AA+ G+++ L +LL   G D++       + L++A  +GH DCVR+LL A A   
Sbjct  66    TPLRLAASYGHLSCLQVLL-AHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPG  124

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAAD---------GGQTPLYLACKNGN  1069
              +  N  +P+  AA  G    ++ L+ + A  N  A              PLYLA   G+
Sbjct  125   GSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGH  184

Query  1070  KECIKLLLEAGTNRSVKTTD  1089
              +C +LLL  G +     TD
Sbjct  185   LDCFRLLLLHGADPDYNCTD  204


 Score = 61.6 bits (148),  Expect = 3e-09
 Identities = 45/165 (27%), Positives = 74/165 (44%), Gaps = 13/165 (7%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSA----LYSAAKNGHTDCVRLLLSAEAQ  1016
             L QA    +   L  LL +E      +   G       L  AA  GH  C+++LL+  A 
Sbjct  30    LNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGAD  89

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             V++ D    TPL  A + GH +CV +L+   A+   +     +P+  A ++G    ++ L
Sbjct  90    VDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQEL  149

Query  1077  LEAGTNRSVKT-TDGWT--------PVHAAVDTGNVDSLKLLMYH  1112
             L+ G   +VK     W         P++ A   G++D  +LL+ H
Sbjct  150   LDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLH  194


 Score = 61.2 bits (147),  Expect = 4e-09
 Identities = 31/92 (33%), Positives = 54/92 (58%), Gaps = 0/92 (0%)

Query  1026  TPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSV  1085
             TPL  AA+ GH  C+++L+++ A+++      QTPL+ A  +G+ +C+++LLEAG +   
Sbjct  66    TPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGG  125

Query  1086  KTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAH  1117
                +  +PV  A   G V  L+ L+ H   A+
Sbjct  126   SIYNNCSPVLTAARDGAVAILQELLDHGAEAN  157


>gi|20532005|sp|Q9Y576|ASB1_HUMAN  Ankyrin repeat and SOCS box protein 1 (ASB-1)
Length=335

 Score = 64.3 bits (155),  Expect = 5e-10
 Identities = 46/131 (35%), Positives = 64/131 (48%), Gaps = 10/131 (7%)

Query  988   CEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGF--------TPLCAAAAQGHFEC  1039
             CED  + L+ AA  G    +R LL  E+  +  ++           TPL  AA  GH  C
Sbjct  36    CED--TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSC  93

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVD  1099
             V+ LI   A ++     GQT LY+A  NG+ E  ++LLEAG + +       TPV+ A  
Sbjct  94    VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASR  153

Query  1100  TGNVDSLKLLM  1110
              G  D LK L+
Sbjct  154   VGRADILKALI  164


 Score = 57.4 bits (137),  Expect = 6e-08
 Identities = 41/139 (29%), Positives = 68/139 (48%), Gaps = 16/139 (11%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L+ AA  G+ + +  L+ + G +++     G +ALY A  NGH +  ++LL A A  N
Sbjct  80    TPLRIAATAGHGSCVDFLIRK-GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPN  138

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANIN---HAADGGQT------------PLYL  1063
              +  +  TP+  A+  G  + ++ LI Y A+++   H     Q             PLY+
Sbjct  139   GSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYI  198

Query  1064  ACKNGNKECIKLLLEAGTN  1082
             +    N +C +LLL AG N
Sbjct  199   SAAYHNLQCFRLLLLAGAN  217


 Score = 55.5 bits (132),  Expect = 2e-07
 Identities = 40/134 (29%), Positives = 59/134 (44%), Gaps = 7/134 (5%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGH-------SALYSAAKNGHTDCVRLLL  1011
             T L  AA  G++  L  LL EE      + +          + L  AA  GH  CV  L+
Sbjct  39    TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI  98

Query  1012  SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKE  1071
                A+V+  D  G T L  A   GH E  ++L+   A+ N +     TP+Y A + G  +
Sbjct  99    RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD  158

Query  1072  CIKLLLEAGTNRSV  1085
              +K L+  G +  V
Sbjct  159   ILKALIRYGADVDV  172


>gi|81175048|sp|Q495M9|USH1G_HUMAN  Usher syndrome type 1G protein (Scaffold protein containing ankyrin 
repeats and SAM domain)
Length=461

 Score = 63.5 bits (153),  Expect = 8e-10
 Identities = 39/114 (34%), Positives = 60/114 (52%), Gaps = 3/114 (2%)

Query  963   QAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK  1022
             +AA  G + LL     +E   +N   EDG +    AA +G+ + +RL++S     +  D 
Sbjct  7     RAARDGYLELLKEATRKE---LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI  63

Query  1023  NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
              G TPL  AA+ GH  C+  L+S+ ANI    +   TPL +A   G+ EC++ L
Sbjct  64    WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL  117


 Score = 60.5 bits (145),  Expect = 7e-09
 Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 2/114 (1%)

Query  996   YSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAAD  1055
             + AA++G+ + ++   +   ++NA D++G TP   AA  G+ E + L++S   + +    
Sbjct  6     HRAARDGYLELLKE--ATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDI  63

Query  1056  GGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
              G TPL+LA  NG+  C+  L+  G N      D  TP+  A   G+++ ++ L
Sbjct  64    WGNTPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYL  117


 Score = 51.6 bits (122),  Expect = 3e-06
 Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 3/91 (3%)

Query  958   PTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             PTL   AA  GN+  L ++++  G D +     G++ L+ AA NGH  C+  L+S  A +
Sbjct  35    PTLW--AAYHGNLESLRLIVSRGG-DPDKCDIWGNTPLHLAASNGHLHCLSFLVSFGANI  91

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDA  1048
                D +  TPL  AA +GH ECV  L S  A
Sbjct  92    WCLDNDYHTPLDMAAMKGHMECVRYLDSIAA  122


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 2/80 (2%)

Query  1031  AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG  1090
             AA  G+ E ++     +  +N   + G TP   A  +GN E ++L++  G +       G
Sbjct  8     AARDGYLELLKEATRKE--LNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWG  65

Query  1091  WTPVHAAVDTGNVDSLKLLM  1110
              TP+H A   G++  L  L+
Sbjct  66    NTPLHLAASNGHLHCLSFLV  85


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 23/58 (39%), Positives = 32/58 (55%), Gaps = 1/58 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ  1016
             T L  AA+ G++  LS L++  G +I     D H+ L  AA  GH +CVR L S  A+
Sbjct  67    TPLHLAASNGHLHCLSFLVSF-GANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAK  123


>gi|20138948|sp|Q04721|NOTC2_HUMAN  Neurogenic locus notch homolog protein 2 precursor (Notch 2) 
(hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular 
domain]
Length=2471

 Score = 63.5 bits (153),  Expect = 8e-10
 Identities = 68/250 (27%), Positives = 108/250 (43%), Gaps = 10/250 (4%)

Query  864   IDLTV-APAGCAVSALATSQVGAWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASS  922
             +D+ V  P GC    LA+ + G+   +          DSS  I T + +  +   + A +
Sbjct  1819  LDVNVRGPDGCTPLMLASLRGGSSDLSD---EDEDAEDSSANIITDLVYQGA--SLQAQT  1873

Query  923   CRPGASDSLLVTASGWSPSLTPLLMSGGPAPLA---GRPTLLQQAAAQGNVTLLSMLLNE  979
              R G     L      + +   LL +G  A      GR  L    AA     +  +L+  
Sbjct  1874  DRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ-GVFQILIRN  1932

Query  980   EGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFEC  1039
                D++    DG + L  AA+      V  L++ +A VNA D +G + L  AAA  + E 
Sbjct  1933  RVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEA  1992

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVD  1099
               LL+   AN +   +  +TPL+LA + G+ E  K+LL+   NR +       P   A D
Sbjct  1993  TLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARD  2052

Query  1100  TGNVDSLKLL  1109
               + D ++LL
Sbjct  2053  RMHHDIVRLL  2062


 Score = 56.6 bits (135),  Expect = 1e-07
 Identities = 54/207 (26%), Positives = 86/207 (41%), Gaps = 41/207 (19%)

Query  943   TPLLMS---GGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAA  999
             TPL+++   GG + L+       + A   +  +++ L+ +       +   G  AL+ AA
Sbjct  1830  TPLMLASLRGGSSDLSDE----DEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAA  1885

Query  1000  KNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAA---QGHFEC-----------------  1039
             +    D  + LL A A  NA D  G  PL AA A   QG F+                  
Sbjct  1886  RYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGT  1945

Query  1040  --------------VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSV  1085
                           V  LI+  A++N   D G++ L+ A    N E   LLL+ G NR +
Sbjct  1946  TPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDM  2005

Query  1086  KTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             +     TP+  A   G+ ++ K+L+ H
Sbjct  2006  QDNKEETPLFLAAREGSYEAAKILLDH  2032


 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 37/132 (28%), Positives = 64/132 (48%), Gaps = 8/132 (6%)

Query  947   MSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDC  1006
             M+ G  PL     L  + A +G   +++ L+N +  D+N   + G SAL+ AA   + + 
Sbjct  1941  MNDGTTPLI----LAARLAVEG---MVAELINCQA-DVNAVDDHGKSALHWAAAVNNVEA  1992

Query  1007  VRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACK  1066
               LLL   A  +  D    TPL  AA +G +E  ++L+ + AN +      + P  +A  
Sbjct  1993  TLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARD  2052

Query  1067  NGNKECIKLLLE  1078
               + + ++LL E
Sbjct  2053  RMHHDIVRLLDE  2064


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 16/114 (14%)

Query  1017  VNAADKNGFTPLCAAAAQG---------------HFECVELLISYDANINHAADG-GQTP  1060
             VN    +G TPL  A+ +G                   +  L+   A++    D  G+  
Sbjct  1821  VNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMA  1880

Query  1061  LYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI  1114
             L+LA +    +  K LL+AG + + +   G  P+HAAV        ++L+ +R+
Sbjct  1881  LHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRV  1934


>gi|46395885|sp|Q8IUH5|ZDH17_HUMAN  Palmitoyltransferase ZDHHC17 (Zinc finger DHHC domain-containing 
protein 17) (DHHC-17) (Huntingtin-interacting protein 14) 
(Huntingtin-interacting protein 3) (Huntingtin-interacting 
protein HYPH) (Putative NF-kappa-B-activating protein 205) 
(Putative MAPK-activating protein PM11)
Length=632

 Score = 63.2 bits (152),  Expect = 1e-09
 Identities = 47/147 (31%), Positives = 75/147 (51%), Gaps = 3/147 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A  QG+++++  L+ + G D +    +G S ++ AA+ GHT  V  L++    V+
Sbjct  126   TPLHWATRQGHLSMVVQLM-KYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVD  184

Query  1019  AADKNGFTPLCAAAAQGH-FECVELLISYDANINHAAD-GGQTPLYLACKNGNKECIKLL  1076
               D+NG TPL  AA + H  +   LL++++ ++N        T L+ A   GN   I LL
Sbjct  185   MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLL  244

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNV  1103
             LEAG N   +   G + +  A    NV
Sbjct  245   LEAGANVDAQNIKGESALDLAKQRKNV  271


 Score = 45.4 bits (106),  Expect = 2e-04
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 6/156 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             TLL  AA    + L+   +++  +      +   + L+ A + GH   V  L+   A  +
Sbjct  92    TLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPS  151

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPL-YLACKNGNKECIKLLL  1077
               D  G + +  AA  GH   V  LI+   +++     G TPL + A +  + +  +LLL
Sbjct  152   LIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLL  211

Query  1078  EAGTNRSVKTTDGW---TPVHAAVDTGNVDSLKLLM  1110
                 N SV   D +   T +H AV  GN   + LL+
Sbjct  212   T--FNVSVNLGDKYHKNTALHWAVLAGNTTVISLLL  245


>gi|20137528|sp|Q9NU02|ANKR5_HUMAN  Ankyrin repeat domain protein 5
Length=776

 Score = 63.2 bits (152),  Expect = 1e-09
 Identities = 41/147 (27%), Positives = 70/147 (47%), Gaps = 1/147 (0%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDIN-YSCEDGHSALYSAAKNGHTDCVRLLLSAE  1014
             G+P  L+      +V  + +   E+G + N  +   G +AL  A++ G  + VR +L   
Sbjct  149   GKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALMEASREGVVEIVRGILERG  208

Query  1015  AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIK  1074
              +VNA D +       AA  G F+ ++LL +Y+ ++   +  G TPL+ A   G  +C K
Sbjct  209   GEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISINGNTPLHYAAMGGFADCCK  268

Query  1075  LLLEAGTNRSVKTTDGWTPVHAAVDTG  1101
              + + G +   K  D  TP   A + G
Sbjct  269   YIAQRGCDLKWKNLDHKTPRAVAKEGG  295


 Score = 58.2 bits (139),  Expect = 3e-08
 Identities = 31/111 (27%), Positives = 59/111 (53%), Gaps = 0/111 (0%)

Query  1000  KNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQT  1059
             K G    ++    +   V+  D    TPL  A A G+ + V+ L+   AN+N   +   T
Sbjct  501   KAGDLASLKKAFESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWT  560

Query  1060  PLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             PL+ AC  G ++ ++LL+E+G      + +  TP++ A+++  +D++K L+
Sbjct  561   PLHFACHAGQQDIVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLL  611


 Score = 56.6 bits (135),  Expect = 1e-07
 Identities = 38/121 (31%), Positives = 60/121 (49%), Gaps = 4/121 (3%)

Query  979   EEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFE  1038
             E G+ ++       + L +A  +G+ D V+ LL   A VNA D   +TPL  A   G  +
Sbjct  513   ESGIPVDMKDNYYKTPLMTACASGNIDVVKFLLEKGANVNATDNFLWTPLHFACHAGQQD  572

Query  1039  CVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
              VELL+   A I+ A+    TPL  A ++   + +K LL+ G    ++   G    H+A+
Sbjct  573   IVELLVESGALIDAASINNSTPLNRAIESCRLDTVKYLLDIGAKFQLENRKG----HSAM  628

Query  1099  D  1099
             D
Sbjct  629   D  629


 Score = 50.8 bits (120),  Expect = 6e-06
 Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 1/121 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L +A+ +G V ++  +L E G ++N    D H A + AAK G  D ++LL +    V 
Sbjct  187   TALMEASREGVVEIVRGIL-ERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVG  245

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
                 NG TPL  AA  G  +C + +     ++       +TP  +A + G K   K +  
Sbjct  246   LISINGNTPLHYAAMGGFADCCKYIAQRGCDLKWKNLDHKTPRAVAKEGGFKAASKEIRR  305

Query  1079  A  1079
             A
Sbjct  306   A  306


 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 35/139 (25%), Positives = 59/139 (42%), Gaps = 3/139 (2%)

Query  974   SMLLNEEGLDINYSCEDGHSALYSAAKNGHT--DCVRLLLSAEAQVNAADKN-GFTPLCA  1030
             +++  E G D+N S  +G      A ++ H   D     L   A  NA + + G T L  
Sbjct  132   ALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTFLEKGANPNAINSSTGRTALME  191

Query  1031  AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG  1090
             A+ +G  E V  ++     +N   +      + A K G  + +KLL     +  + + +G
Sbjct  192   ASREGVVEIVRGILERGGEVNAFDNDRHHAAHFAAKGGFFDILKLLFAYNGDVGLISING  251

Query  1091  WTPVHAAVDTGNVDSLKLL  1109
              TP+H A   G  D  K +
Sbjct  252   NTPLHYAAMGGFADCCKYI  270


 Score = 43.5 bits (101),  Expect = 9e-04
 Identities = 35/152 (23%), Positives = 70/152 (46%), Gaps = 6/152 (3%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  A+   ++ ++S LL + G   +     G +    AA+ GH   + +L  A+A +   
Sbjct  52    LHLASVSNDIDMVSFLL-DLGAHPDVQDRMGCTPTMRAAELGHELSMEILAKAKADMTIV  110

Query  1021  DKNGFTPL--CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGN--KECIKLL  1076
             D  G   L  C    + H+ C  + + + A++N++   G+     AC++ +  K+     
Sbjct  111   DNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEGKPIFLRACEDAHDVKDVCLTF  170

Query  1077  LEAGTN-RSVKTTDGWTPVHAAVDTGNVDSLK  1107
             LE G N  ++ ++ G T +  A   G V+ ++
Sbjct  171   LEKGANPNAINSSTGRTALMEASREGVVEIVR  202


 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 3/110 (2%)

Query  984   INYSCE-DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVEL  1042
             INY+   +G SAL+ A+ +   D V  LL   A  +  D+ G TP   AA  GH   +E+
Sbjct  40    INYTEPINGLSALHLASVSNDIDMVSFLLDLGAHPDVQDRMGCTPTMRAAELGHELSMEI  99

Query  1043  LISYDANINHAADGGQTPLY--LACKNGNKECIKLLLEAGTNRSVKTTDG  1090
             L    A++    + G+  L+  +     +  C  + LE G + +  T +G
Sbjct  100   LAKAKADMTIVDNEGKGVLFYCILPTKRHYRCALIALEHGADVNNSTYEG  149


>gi|28558073|sp|Q9NXR5|ANR10_HUMAN  Ankyrin repeat domain protein 10
Length=420

 Score = 62.8 bits (151),  Expect = 1e-09
 Identities = 54/222 (24%), Positives = 99/222 (44%), Gaps = 46/222 (20%)

Query  981   GLDINYSCEDGHSA---LYSAAKNGHTDCVRLLLSAEAQVNAADKN---GFTPLCAAAAQ  1034
             G++  +S E+  S    L+ A ++G    +  LL      + A ++   G+TP+  AA  
Sbjct  9     GVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHF  68

Query  1035  GHFECVELLISYDANINHAADG-GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP  1093
             G  EC+  L+   A +N +     QTP ++A   G+ +C+  L++AG N +    +G TP
Sbjct  69    GKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETP  128

Query  1094  VHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPADLI  1153
             +H A  +G+++ +  L+ +   AH                                   +
Sbjct  129   IHKAARSGSLECISALVAN--GAH-----------------------------------V  151

Query  1154  NHANREGWTAAHIAASKGFKDCNLPDALLAFSHMRVRRFYSH  1195
             +  N  G TAA IA ++GF++C    +LL   +  +  FY++
Sbjct  152   DLRNASGLTAADIAQTQGFQEC--AQSLLNLQNCHLNHFYNN  191


 Score = 60.1 bits (144),  Expect = 9e-09
 Identities = 44/145 (30%), Positives = 71/145 (48%), Gaps = 5/145 (3%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCED---GHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             L +A   G++  L  LL +     + + ED   G + ++ AA  G  +C+  L+ A A +
Sbjct  26    LHRACRDGDLATLCSLLQQTP-HAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL  84

Query  1018  NAAD-KNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             N +  +   TP   AA  GH +C+  LI   ANIN     G+TP++ A ++G+ ECI  L
Sbjct  85    NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL  144

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTG  1101
             +  G +  ++   G T    A   G
Sbjct  145   VANGAHVDLRNASGLTAADIAQTQG  169


 Score = 52.0 bits (123),  Expect = 3e-06
 Identities = 37/120 (30%), Positives = 56/120 (46%), Gaps = 2/120 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCED-GHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             T +  AA  G +  L  L+   G  +N S      +  + AA  GH  C+  L+ A A +
Sbjct  60    TPVHWAAHFGKLECLVQLVRA-GATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANI  118

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             N  D  G TP+  AA  G  EC+  L++  A+++     G T   +A   G +EC + LL
Sbjct  119   NKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQSLL  178


 Score = 45.8 bits (107),  Expect = 2e-04
 Identities = 31/120 (25%), Positives = 57/120 (47%), Gaps = 7/120 (5%)

Query  965   AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG  1024
             AA G      + L + G +IN    +G + ++ AA++G  +C+  L++  A V+  + +G
Sbjct  99    AAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASG  158

Query  1025  FTPLCAAAAQGHFECVELLIS-YDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNR  1083
              T    A  QG  EC + L++  + ++NH  + G          G++      +  GTNR
Sbjct  159   LTAADIAQTQGFQECAQSLLNLQNCHLNHFYNNG------ILNGGHQNVFPNHISVGTNR  212


>gi|34222827|sp|Q86YR6|ANR21_HUMAN  Ankyrin repeat domain protein 21 (POTE protein) (Prostate, ovary, 
testis expressed protein)
Length=584

 Score = 62.8 bits (151),  Expect = 1e-09
 Identities = 45/150 (30%), Positives = 71/150 (47%), Gaps = 0/150 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G V    +++     D+N   ++  +AL+ A+ NG+++ V+LLL    Q+N  
Sbjct  143   LHRAAWWGKVPRKDLIVMLRDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVL  202

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D    T L  A      ECV +L+ + A+ N   + G T L+ A  N +K   K LL  G
Sbjct  203   DNKKRTALIKAIQCQEDECVLMLLEHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYG  262

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              +   K   G TP+   V       +K L+
Sbjct  263   ADIESKNKCGLTPLLLGVHEQKQQVVKFLI  292


 Score = 55.1 bits (131),  Expect = 3e-07
 Identities = 44/144 (30%), Positives = 66/144 (45%), Gaps = 2/144 (1%)

Query  957   RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ  1016
             R  L++    Q +  +L +L  E G D N   E G++AL+ A  N      + LL   A 
Sbjct  207   RTALIKAIQCQEDECVLMLL--EHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYGAD  264

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             + + +K G TPL     +   + V+ LI   AN+N     G+T L LA   G+   + LL
Sbjct  265   IESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIVNLL  324

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDT  1100
             LE   + S +   G T    AV +
Sbjct  325   LEQNVDVSSQDLSGQTAREYAVSS  348


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 0/66 (0%)

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL  1106
             D ++N      +T L+LA  NGN E ++LLL+     +V      T +  A+     + +
Sbjct  163   DTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECV  222

Query  1107  KLLMYH  1112
              +L+ H
Sbjct  223   LMLLEH  228


>gi|22256976|sp|Q96I34|PP16A_HUMAN  Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase 
target subunit 3)
Length=528

 Score = 62.4 bits (150),  Expect = 2e-09
 Identities = 50/183 (27%), Positives = 78/183 (42%), Gaps = 30/183 (16%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L Q        ++  LL E G +IN    +  + L++AA  GH   V LL+++ A + 
Sbjct  106   TALHQCCIDDFREMVQQLL-EAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLL  164

Query  1019  AADKNGFTPLCAAAAQGHFECVELLIS-----------------------------YDAN  1049
             A + +G  P      +   +C+E  ++                               A+
Sbjct  165   AVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGAD  224

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             ++   D G T L++A  NG  E   LLLE   + S K  DGW P+HAA   G V  ++LL
Sbjct  225   LHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELL  284

Query  1110  MYH  1112
             + H
Sbjct  285   VAH  287


 Score = 61.6 bits (148),  Expect = 3e-09
 Identities = 51/183 (27%), Positives = 77/183 (42%), Gaps = 30/183 (16%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             +L +AAA+ ++  +   L   G+  + + EDG +AL+    +   + V+ LL A A +NA
Sbjct  74    VLLEAAARNDLEEVRQFLGS-GVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINA  132

Query  1020  ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKEC-------  1072
              D   +TPL AAA  GH   VELLI+  AN+      G  P  L       +C       
Sbjct  133   CDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMAD  192

Query  1073  ----------------------IKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
                                   I+  L+AG +       G T +H A   G  ++  LL+
Sbjct  193   RGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLL  252

Query  1111  YHR  1113
              HR
Sbjct  253   EHR  255


 Score = 57.8 bits (138),  Expect = 5e-08
 Identities = 35/100 (35%), Positives = 58/100 (58%), Gaps = 3/100 (3%)

Query  979   EEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFE  1038
             + G D++   + G + L+ AA NG ++   LLL   A ++A D++G+ PL AAA  G   
Sbjct  220   QAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVP  279

Query  1039  CVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
              VELL+++ A++N  +   +TPL +    G++E    LLE
Sbjct  280   LVELLVAHGADLNAKSLMDETPLDVC---GDEEVRAKLLE  316


 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 0/95 (0%)

Query  1005  DCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLA  1064
             D +R  L A A ++A   +G T L  AAA G  E   LL+ + A+++     G  PL+ A
Sbjct  213   DDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAA  272

Query  1065  CKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVD  1099
                G    ++LL+  G + + K+    TP+    D
Sbjct  273   AYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGD  307


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 28/77 (36%), Positives = 38/77 (49%), Gaps = 1/77 (1%)

Query  952   APLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL  1011
             APL    TLL  AAA G     ++LL E    ++   +DG   L++AA  G    V LL+
Sbjct  227   APLDHGATLLHVAAANGFSEAAALLL-EHRASLSAKDQDGWEPLHAAAYWGQVPLVELLV  285

Query  1012  SAEAQVNAADKNGFTPL  1028
             +  A +NA      TPL
Sbjct  286   AHGADLNAKSLMDETPL  302


>gi|55976443|sp|Q6S5H4|POT15_HUMAN  Prostate, ovary, testis expressed protein on chromosome 15
Length=581

 Score = 62.0 bits (149),  Expect = 2e-09
 Identities = 45/150 (30%), Positives = 70/150 (46%), Gaps = 0/150 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G V    +++     D+N   +   +AL+ A+ NG+++ V+LLL    Q+N  
Sbjct  143   LHRAAWWGKVPRKDLIVMLRDTDMNKRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVL  202

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D    T L  A      ECV +L+ + A+ N   + G T L+ A  N +K   K LL  G
Sbjct  203   DNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALHYAIYNEDKLMAKALLLYG  262

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              +   K   G TP+   V       +K L+
Sbjct  263   ADIESKNKCGLTPLLLGVHEQKQQVVKFLI  292


 Score = 55.8 bits (133),  Expect = 2e-07
 Identities = 44/144 (30%), Positives = 66/144 (45%), Gaps = 2/144 (1%)

Query  957   RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ  1016
             R  L++    Q +  +L +L  E G D N   E G++AL+ A  N      + LL   A 
Sbjct  207   RTALIKAVQCQEDECVLMLL--EHGADGNIQDEYGNTALHYAIYNEDKLMAKALLLYGAD  264

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             + + +K G TPL     +   + V+ LI   AN+N     G+T L LA   G+   + LL
Sbjct  265   IESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVNLL  324

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDT  1100
             LE   + S +   G T    AV +
Sbjct  325   LEQNVDVSSQDLSGQTAREYAVSS  348


 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 31/129 (24%), Positives = 51/129 (39%), Gaps = 10/129 (7%)

Query  968   GNVTLLSMLLNEE----------GLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             GN  L   + NE+          G DI    + G + L           V+ L+  +A +
Sbjct  239   GNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFLIKKKANL  298

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             NA D+ G T L  A   G    V LL+  + +++     GQT    A  + +    +LL 
Sbjct  299   NALDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICELLS  358

Query  1078  EAGTNRSVK  1086
             +    + +K
Sbjct  359   DYKEKQMLK  367


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 19/66 (28%), Positives = 32/66 (48%), Gaps = 0/66 (0%)

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL  1106
             D ++N      +T L+LA  NGN E ++LLL+     +V      T +  AV     + +
Sbjct  163   DTDMNKRDKQKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAVQCQEDECV  222

Query  1107  KLLMYH  1112
              +L+ H
Sbjct  223   LMLLEH  228


>gi|20139284|sp|Q9UM47|NOTC3_HUMAN  Neurogenic locus notch homolog protein 3 precursor (Notch 3) 
[Contains: Notch 3 extracellular truncation; Notch 3 intracellular 
domain]
Length=2321

 Score = 61.6 bits (148),  Expect = 3e-09
 Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 3/146 (2%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN  1023
             A AQG   +  +L+     D++    DG +AL  AA+      V  L+++ A VNA D+ 
Sbjct  1882  ADAQG---VFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDEL  1938

Query  1024  GFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNR  1083
             G + L  AAA  + E    L+   AN +      +TPL+LA + G+ E  KLLL+   NR
Sbjct  1939  GKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANR  1998

Query  1084  SVKTTDGWTPVHAAVDTGNVDSLKLL  1109
              +       P   A +  + D ++LL
Sbjct  1999  EITDHLDRLPRDVAQERLHQDIVRLL  2024


 Score = 56.6 bits (135),  Expect = 1e-07
 Identities = 52/197 (26%), Positives = 78/197 (39%), Gaps = 45/197 (22%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAA---AQGHFEC--------  1039
             G +AL+ AA+    D  + LL A A  NA D +G TPL  A    AQG F+         
Sbjct  1839  GETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTD  1898

Query  1040  -----------------------VELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
                                    VE LI+  A++N   + G++ L+ A    N E    L
Sbjct  1899  LDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLAL  1958

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH-----------RIPAHGnsfneee  1125
             L+ G N+ ++ +   TP+  A   G+ ++ KLL+ H           R+P         +
Sbjct  1959  LKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQ  2018

Query  1126  sessVFDLDGGEESPEG  1142
                 + D   G  SP G
Sbjct  2019  DIVRLLDQPSGPRSPPG  2035


 Score = 44.3 bits (103),  Expect = 5e-04
 Identities = 42/151 (27%), Positives = 66/151 (43%), Gaps = 10/151 (6%)

Query  954   LAGRPTLLQQAAAQGNVTL-LSMLLNEEGL---------DINYSCEDGHSALYSAAKNGH  1003
             +  R T L    A G+  L L+  L  EG+         D+N   E G SAL+ AA   +
Sbjct  1892  IRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNN  1951

Query  1004  TDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL  1063
              +    LL   A  +  D    TPL  AA +G +E  +LL+ + AN        + P  +
Sbjct  1952  VEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDV  2011

Query  1064  ACKNGNKECIKLLLEAGTNRSVKTTDGWTPV  1094
             A +  +++ ++LL +    RS     G  P+
Sbjct  2012  AQERLHQDIVRLLDQPSGPRSPPGPHGLGPL  2042


 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 17/114 (14%)

Query  1017  VNAADKNGFTPLCAAAAQG----------------HFECVELLISYDANINHAADG-GQT  1059
             VN    +GFTPL  A+  G                    +  LI   A +    D  G+T
Sbjct  1782  VNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGET  1841

Query  1060  PLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
              L+LA +    +  K LL+AG + + +   G TP+H AV        ++L+ +R
Sbjct  1842  ALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNR  1895


>gi|55976445|sp|Q6S8J3|POTE2_HUMAN  Prostate, ovary, testis expressed protein on chromosome 2
Length=712

 Score = 61.6 bits (148),  Expect = 3e-09
 Identities = 43/150 (28%), Positives = 68/150 (45%), Gaps = 0/150 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G V    +++     D+N   +   +AL+ A+ NG+++ V+LLL    Q+N  
Sbjct  143   LHRAAWWGKVPRKDLIVMLRDTDVNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVL  202

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D    T L  A      EC  +L+ +  + N   + G T L+ A  N +K   K LL  G
Sbjct  203   DNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYG  262

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              +   K   G TP+   V       +K L+
Sbjct  263   ADIESKNKHGLTPLLLGVHEQKQQVVKFLI  292


 Score = 55.1 bits (131),  Expect = 3e-07
 Identities = 39/127 (30%), Positives = 60/127 (47%), Gaps = 0/127 (0%)

Query  974   SMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAA  1033
             +++L E G D N   E G++ L+ A  N      + LL   A + + +K+G TPL     
Sbjct  222   ALMLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVH  281

Query  1034  QGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP  1093
             +   + V+ LI   AN+N     G+T L LA   G+   + LLLE   + S +   G T 
Sbjct  282   EQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA  341

Query  1094  VHAAVDT  1100
                AV +
Sbjct  342   REYAVSS  348


 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 32/129 (24%), Positives = 52/129 (40%), Gaps = 10/129 (7%)

Query  968   GNVTLLSMLLNEE----------GLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             GN TL   + NE+          G DI    + G + L           V+ L+  +A +
Sbjct  239   GNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANL  298

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             NA D+ G T L  A   G    V LL+  + +++     GQT    A  + +    +LL 
Sbjct  299   NALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSHHHVICQLLS  358

Query  1078  EAGTNRSVK  1086
             +    + +K
Sbjct  359   DYKEKQMLK  367


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 0/66 (0%)

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL  1106
             D ++N      +T L+LA  NGN E +KLLL+     +V      T +  AV     +  
Sbjct  163   DTDVNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALIKAVQCQEDECA  222

Query  1107  KLLMYH  1112
              +L+ H
Sbjct  223   LMLLEH  228


>gi|1350802|sp|Q05823|RN5A_HUMAN  2-5A-dependent ribonuclease (2-5A-dependent RNase) (Ribonuclease 
L) (RNase L) (Ribonuclease 4)
Length=741

 Score = 61.2 bits (147),  Expect = 4e-09
 Identities = 54/178 (30%), Positives = 84/178 (47%), Gaps = 18/178 (10%)

Query  950   GPAPLAGRPT------LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGH-SALYSAAKNG  1002
             GP   +GR        LL +A    +V L+  LL E G ++N+  E+G  + L++A +  
Sbjct  12    GPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLL-EGGANVNFQEEEGGWTPLHNAVQMS  70

Query  1003  HTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLY  1062
               D V LLL   A      KNG TP   AA  G  + ++L +S  A++N     G T   
Sbjct  71    REDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFM  130

Query  1063  LACKNGNKECIKLLLEAGTNRSV--KTTD--------GWTPVHAAVDTGNVDSLKLLM  1110
              A   G  + +K L + G N ++  KT +        G T +  A + G+V+ LK+L+
Sbjct  131   EAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL  188


 Score = 58.2 bits (139),  Expect = 3e-08
 Identities = 44/132 (33%), Positives = 63/132 (47%), Gaps = 5/132 (3%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCV----RLLL  1011
             G  T L  AA +G+V +L +LL+E G D+N     G +AL  A  +     V     LLL
Sbjct  167   GGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLL  226

Query  1012  SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYD-ANINHAADGGQTPLYLACKNGNK  1070
                A VN   + G TPL  A  + H   V+ L+  +   IN     G+T L LA +   K
Sbjct  227   DHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLK  286

Query  1071  ECIKLLLEAGTN  1082
             +  +LL + G +
Sbjct  287   KIAELLCKRGAS  298


 Score = 52.0 bits (123),  Expect = 3e-06
 Identities = 55/213 (25%), Positives = 94/213 (44%), Gaps = 29/213 (13%)

Query  926   GASDSLLVTASGWSP----------SLTPLLMSGGPAPLAGRP---TLLQQAAAQGNVTL  972
             GA+ +      GW+P           +  LL+  G  P+  +    T    AA  G+V L
Sbjct  48    GANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKL  107

Query  973   LSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN---------  1023
             L + L++ G D+N     G +A   AA  G    ++ L    A VN   K          
Sbjct  108   LKLFLSK-GADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRK  166

Query  1024  -GFTPLCAAAAQGHFECVELLIS-YDANINHAADGGQTPLYLACKNGNKECIK----LLL  1077
              G T L  AA +GH E +++L+    A++N   + G+  L  A  + +   ++    LLL
Sbjct  167   GGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLL  226

Query  1078  EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             + G + +V+   G TP+  AV+  ++  ++ L+
Sbjct  227   DHGADVNVRGERGKTPLILAVEKKHLGLVQRLL  259


 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 19/53 (35%), Positives = 31/53 (58%), Gaps = 1/53 (1%)

Query  1061  LYLACKNGNKECIKLLLEAGTNRSVKTTDG-WTPVHAAVDTGNVDSLKLLMYH  1112
             L  A +N + + ++ LLE G N + +  +G WTP+H AV     D ++LL+ H
Sbjct  29    LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH  81


>gi|23503070|sp|Q06547|GABP2_HUMAN  GA-binding protein beta chain (GABP-beta-2 subunit) (GABP-2) 
(GABP-beta-1 subunit) (GABPB-1) (Transcription factor E4TF1-53) 
(Transcription factor E4TF1-47) (Nuclear respiratory factor 
2)
Length=395

 Score = 60.8 bits (146),  Expect = 5e-09
 Identities = 37/119 (31%), Positives = 64/119 (53%), Gaps = 0/119 (0%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANI  1050
             G S L+ AA+ GH     +LL A    +A  K   TPL  AA++GH   VE+L+ + A++
Sbjct  38    GTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADV  97

Query  1051  NHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             N       T L+ A ++ ++E ++LL++ G +   ++    T    ++D GN D  ++L
Sbjct  98    NAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEIL  156


 Score = 58.5 bits (140),  Expect = 3e-08
 Identities = 51/179 (28%), Positives = 83/179 (46%), Gaps = 15/179 (8%)

Query  922   SCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEG  981
             + R G  D + +  +  +P  T  L   G +PL         AA  G+ +   +LL   G
Sbjct  13    AARAGQDDEVRILMANGAPFTTDWL---GTSPL-------HLAAQYGHYSTTEVLLRA-G  61

Query  982   LDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVE  1041
             +  +   +   + L+ AA  GH   V +LL   A VNA D    T L  A    H E VE
Sbjct  62    VSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVE  121

Query  1042  LLISYDANINHAADGGQTPLYLACKNGNK---ECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
             LLI Y A+++  +   +T   ++  NGN+   E +++ ++   N + ++ D  T +HAA
Sbjct  122   LLIKYGADVHTQSKFCKTAFDISIDNGNEDLAEILQIAMQNQINTNPESPDTVT-IHAA  179


 Score = 53.1 bits (126),  Expect = 1e-06
 Identities = 34/123 (27%), Positives = 62/123 (50%), Gaps = 1/123 (0%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA  1054
             L  AA+ G  D VR+L++  A     D  G +PL  AA  GH+   E+L+    + +   
Sbjct  10    LLEAARAGQDDEVRILMANGAPFTT-DWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART  68

Query  1055  DGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI  1114
                +TPL++A   G+   +++LL+ G + + K     T +H A +  + + ++LL+ +  
Sbjct  69    KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGA  128

Query  1115  PAH  1117
               H
Sbjct  129   DVH  131


>gi|62900369|sp|Q8TC84|FANK1_HUMAN  Fibronectin type 3 and ankyrin repeat domains protein 1
Length=345

 Score = 60.1 bits (144),  Expect = 9e-09
 Identities = 36/102 (35%), Positives = 56/102 (54%), Gaps = 2/102 (1%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADK-NGFTPLC-AAAAQGHFECVELLISYDA  1048
             G +AL+ AA  GH   +  ++    +V+  D  +G+TPL   +A  G+     LLI   A
Sbjct  210   GCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGA  269

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG  1090
             N+N     G+TPL +A  N ++E ++LLL+ G + SVK   G
Sbjct  270   NVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFG  311


 Score = 57.8 bits (138),  Expect = 5e-08
 Identities = 31/104 (29%), Positives = 54/104 (51%), Gaps = 0/104 (0%)

Query  1007  VRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACK  1066
             VR+L     +V+  +K GFT L  AA +G+   V++L+S   ++N     G+  L LAC 
Sbjct  127   VRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACY  186

Query  1067  NGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G+ + +K L   G +   +   G T +H A D G+   ++ ++
Sbjct  187   AGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMI  230


 Score = 57.4 bits (137),  Expect = 6e-08
 Identities = 49/185 (26%), Positives = 85/185 (45%), Gaps = 35/185 (18%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +A +  +  LL  +L    + ++   + G +AL  AA+ G+T  V++L+S    VN  
Sbjct  114   LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK  173

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDAN-----------INHAADGGQ-----------  1058
             + +G   L  A   GH + V+ L  + A+           ++ AADGG            
Sbjct  174   NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG  233

Query  1059  ------------TPLY-LACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDS  1105
                         TPL  ++  +GN+    LL++AG N +VK  +G TP+  AV   + + 
Sbjct  234   CEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEEL  293

Query  1106  LKLLM  1110
             ++LL+
Sbjct  294   VQLLL  298


 Score = 45.1 bits (105),  Expect = 3e-04
 Identities = 36/125 (28%), Positives = 62/125 (49%), Gaps = 3/125 (2%)

Query  956   GRPTLLQQAAAQGNVTLLSMLLNEEGLDINY-SCEDGHSALYS-AAKNGHTDCVRLLLSA  1013
             G  T L  AA  G+ +++  ++ ++G +++      G + L   +A +G+     LL+ A
Sbjct  209   GGCTALHWAADGGHCSVIEWMI-KDGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDA  267

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
              A VN  D+NG TPL  A    H E V+LL+   A+ +   + G+  L +A     +  +
Sbjct  268   GANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLEMARVFDRQSVV  327

Query  1074  KLLLE  1078
              LL E
Sbjct  328   SLLEE  332


 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 24/113 (21%)

Query  912   CSSINPVSASSCRPGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAAAQGNVT  971
             CS I  +    C     D    T SGW+P                   L++ +A  GN  
Sbjct  223   CSVIEWMIKDGCEVDVVD----TGSGWTP-------------------LMRVSAVSGNQR  259

Query  972   LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG  1024
             + S+L+ + G ++N    +G + L  A  N H + V+LLL   A  +  ++ G
Sbjct  260   VASLLI-DAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFG  311


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 17/56 (30%), Positives = 29/56 (51%), Gaps = 0/56 (0%)

Query  1057  GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             G T L +A + G    +K+L+  GT+ ++K   G   +  A   G++D +K L  H
Sbjct  144   GFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRH  199


>gi|73920184|sp|Q14678|ANR15_HUMAN  Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat-containing 
protein)
Length=1352

 Score = 59.7 bits (143),  Expect = 1e-08
 Identities = 41/133 (30%), Positives = 72/133 (54%), Gaps = 6/133 (4%)

Query  984   INYSCEDGHSALYSAAKNGHTDCVRLLLSAEA-QVNAADKNGFTPLCAAA-----AQGHF  1037
             IN +  +G++AL+ +  + + + V+LLL A+   V+  +K G+TP+  AA     A+   
Sbjct  1155  INLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDM  1214

Query  1038  ECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
               VE L         A+  GQT L LA  +G  + +K LL  G + +++  +G T +  A
Sbjct  1215  RIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCA  1274

Query  1098  VDTGNVDSLKLLM  1110
              + G+V+ +KLL+
Sbjct  1275  SEHGHVEIVKLLL  1287


 Score = 57.8 bits (138),  Expect = 5e-08
 Identities = 44/160 (27%), Positives = 80/160 (50%), Gaps = 6/160 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAE----  1014
             T L  + +  N  ++ +LL+ +  ++++  + G++ +  AA         + +  E    
Sbjct  1164  TALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGC  1223

Query  1015  AQVNA-ADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
               VNA A + G T L  A + G  + V+ L++  A++N   D G T L  A ++G+ E +
Sbjct  1224  GDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIV  1283

Query  1074  KLLL-EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             KLLL + G N  ++  DG T +  A++ G+ D   LL  H
Sbjct  1284  KLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAH  1323


>gi|6685712|sp|O60733|PA2G6_HUMAN  85 kDa calcium-independent phospholipase A2 (iPLA2) (CaI-PLA2) 
(Group VI phospholipase A2) (GVI PLA2)
Length=806

 Score = 59.3 bits (142),  Expect = 2e-08
 Identities = 39/127 (30%), Positives = 66/127 (51%), Gaps = 3/127 (2%)

Query  969   NVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPL  1028
             N  +  MLL + G ++N +   G++AL+ A      DC  +LL+  A  +A  ++G TPL
Sbjct  296   NAEMARMLL-KRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPL  354

Query  1029  CAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTT  1088
               A ++ + E ++ LI + A ++   D G+TP +LA K G     K +L     R+V   
Sbjct  355   HLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILT--LLRTVGAE  412

Query  1089  DGWTPVH  1095
               + P+H
Sbjct  413   YCFPPIH  419


 Score = 58.5 bits (140),  Expect = 3e-08
 Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 6/156 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T+   A    N  +L +L       +N     G + L+ A + G  + VR+LL   A+ N
Sbjct  188   TVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCN  247

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG--GQTPLYLACKNGNKECIKLL  1076
                 NG+ P+ +A       C E++IS D++  H+ D   G +PL+ A    N E  ++L
Sbjct  248   IMGPNGY-PIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARML  303

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             L+ G N +  ++ G T +H AV     D   +L+ H
Sbjct  304   LKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTH  339


 Score = 57.0 bits (136),  Expect = 8e-08
 Identities = 35/112 (31%), Positives = 52/112 (46%), Gaps = 2/112 (1%)

Query  999   AKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQ  1058
             AKN   +  R+LL     VN+    G T L  A  +  F+C  +L+++ AN +   + G 
Sbjct  294   AKNA--EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGN  351

Query  1059  TPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             TPL+LA    N E IK L+  G         G TP   A   G + + K ++
Sbjct  352   TPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAIL  403


 Score = 45.8 bits (107),  Expect = 2e-04
 Identities = 31/112 (27%), Positives = 59/112 (52%), Gaps = 3/112 (2%)

Query  989   EDGHSALYSAAKNGHTDC-VRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL-ISY  1046
             E+G + L+ A + G  +  V L+     Q++  D  G T    A    + + ++LL  + 
Sbjct  150   EEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNA  209

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
              A +N   + G TPL+LAC+ G +E +++LL      ++   +G+ P+H+A+
Sbjct  210   VAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAM  260


>gi|41017271|sp|O60237|MYPT2_HUMAN  Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase 
targeting subunit 2) (Myosin phosphatase target subunit 
2)
Length=982

 Score = 58.9 bits (141),  Expect = 2e-08
 Identities = 44/135 (32%), Positives = 64/135 (47%), Gaps = 4/135 (2%)

Query  944   PLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGH  1003
             PL   G P        +   A + G+   +  LL   G DIN    DG +AL+ A  + +
Sbjct  45    PLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLL-ARGADINTVNVDGLTALHQACIDEN  103

Query  1004  TDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL  1063
              D V+ L+   A VN  D  G+TPL AAA+ G+    E  I++ A++      G+ P  L
Sbjct  104   LDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDL  163

Query  1064  ACKNGNKECIKLLLE  1078
             A +   K+   LLLE
Sbjct  164   AEEPAMKD---LLLE  175


 Score = 57.8 bits (138),  Expect = 5e-08
 Identities = 50/187 (26%), Positives = 82/187 (43%), Gaps = 13/187 (6%)

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDA  1048
             EDG +   +A  +G TD VR LL+  A +N  + +G T L  A    + + V+ L+   A
Sbjct  57    EDG-AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRA  115

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKL  1108
             N+N   + G TPL+ A   G     +  +  G +  +  ++G  P     D     ++K 
Sbjct  116   NVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVP----SDLAEEPAMKD  171

Query  1109  LMYHRIPAHGnsfneeesessVFDL-DGGEESPEGISKPVVPADLINHANREGWTAAHIA  1167
             L+  ++   G    +   E     L D  +    G  + V  A       R G TA H+A
Sbjct  172   LLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQA-------RSGATALHVA  224

Query  1168  ASKGFKD  1174
             A+KG+ +
Sbjct  225   AAKGYSE  231


 Score = 50.4 bits (119),  Expect = 7e-06
 Identities = 41/138 (29%), Positives = 66/138 (47%), Gaps = 8/138 (5%)

Query  972   LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAA  1031
             LL   + ++G+D+  S ++    +   A+       + L S + +     ++G T L  A
Sbjct  172   LLLEQVKKQGIDLEQSRKEEEQQMLQDAR-------QWLNSGKIEDVRQARSGATALHVA  224

Query  1032  AAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW  1091
             AA+G+ E + LLI     +N     G TPL+ A   G KE   +L EA  +  ++   G 
Sbjct  225   AAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQ  284

Query  1092  TPVHAAVDTGNVDSLKLL  1109
             TP   A D G V+ L+LL
Sbjct  285   TPFDVA-DEGLVEHLELL  301


>gi|57012588|sp|Q6W2J9|BCOR_HUMAN  BCoR protein (BCL-6 corepressor)
Length=1755

 Score = 58.9 bits (141),  Expect = 2e-08
 Identities = 37/101 (36%), Positives = 52/101 (51%), Gaps = 0/101 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             TLLQ+AA  G   ++   L  +  D+N+    G+ AL+ A   G  + VR LL   A VN
Sbjct  1465  TLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVN  1524

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQT  1059
              + ++G  PL  A    H E V LL+SY A+   A   G+T
Sbjct  1525  CSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRT  1565


 Score = 54.3 bits (129),  Expect = 5e-07
 Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAE-AQVNAADKNGFTPLCAAAAQGHFECVELLISYDAN  1049
             G + L  AA+ G+ + V   L  +   VN  D  G+  L  A A+G    V  L+ Y A+
Sbjct  1463  GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD  1522

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT  1092
             +N +A  G  PL+ A +N + E ++LLL  G + ++ T  G T
Sbjct  1523  VNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRT  1565


 Score = 44.7 bits (104),  Expect = 4e-04
 Identities = 30/99 (30%), Positives = 51/99 (51%), Gaps = 2/99 (2%)

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVEL--LISYDANINHAADGGQTPLYLACKNGNKE  1071
             EA+    +KN    L   AA+  +E V L  L +   ++NH  + G   L+ AC  G   
Sbjct  1452  EARRLIVNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLN  1511

Query  1072  CIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              ++ LLE G + +    DG  P+H AV+  +++ ++LL+
Sbjct  1512  IVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLL  1550


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 32/122 (26%), Positives = 49/122 (40%), Gaps = 12/122 (9%)

Query  510  RKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKL  569
            RK   Q ++   S P L     TKD     + + ++           D+    ADHMKK+
Sbjct  411  RKTAVQDRKDGSSPPLLEKQTVTKDVTDKPLDLSSK---------VVDVDASKADHMKKM  461

Query  570  PLTMPVKPSTGSPLVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPAFPPPSANKIE  629
              T+ V    GS LV     GS     T++ PG        ++I  +  ++  P  +  E
Sbjct  462  APTVLVHSRAGSGLV---LSGSEIPKETLSPPGNGCAIYRSEIISTAPSSWVVPGPSPNE  518

Query  630  EN  631
            EN
Sbjct  519  EN  520


>gi|68565531|sp|Q96AX9|MIB2_HUMAN  Ubiquitin ligase protein MIB2 (Mind bomb homolog 2) (Zinc finger 
ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) 
(Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating 
protein 002N)
Length=1013

 Score = 58.5 bits (140),  Expect = 3e-08
 Identities = 39/137 (28%), Positives = 71/137 (51%), Gaps = 2/137 (1%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQ-VNAADK  1022
             +A  G   ++ +L     +D+  +   G + L+ A+  GH   VR +L+   Q V+A  +
Sbjct  631   SAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHHASLKGHALAVRKILARARQLVDAKKE  690

Query  1023  NGFTPLCAAAAQGHFECVELLISYD-ANINHAADGGQTPLYLACKNGNKECIKLLLEAGT  1081
             +GFT L  AA   H E  ++LI     ++N      Q+PL+LA +  +   + LL++AG 
Sbjct  691   DGFTALHLAALNNHREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLVPLLVDAGC  750

Query  1082  NRSVKTTDGWTPVHAAV  1098
             + + +  +G T +H A+
Sbjct  751   SVNAEDEEGDTALHVAL  767


 Score = 55.5 bits (132),  Expect = 2e-07
 Identities = 42/144 (29%), Positives = 62/144 (43%), Gaps = 1/144 (0%)

Query  958   PTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             P  L    A GN      LL      ++     G +AL  AA  G  + +RLLL A A V
Sbjct  491   PGRLVVEVALGNAARALDLLRRRPEQVDTK-NQGRTALQVAAYLGQVELIRLLLQARAGV  549

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             +  D  G T L  AA     E   +L+S     +       T L++A + G  E ++ L 
Sbjct  550   DLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALC  609

Query  1078  EAGTNRSVKTTDGWTPVHAAVDTG  1101
             E G + ++      TP+H+A+  G
Sbjct  610   ERGCDVNLPDAHSDTPLHSAISAG  633


 Score = 50.8 bits (120),  Expect = 6e-06
 Identities = 31/107 (28%), Positives = 53/107 (49%), Gaps = 1/107 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL-SAEAQV  1017
             TLL  A+ +G+   +  +L      ++   EDG +AL+ AA N H +  ++L+      V
Sbjct  660   TLLHHASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNNHREVAQILIREGRCDV  719

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLA  1064
             N  ++   +PL  A  Q H   V LL+    ++N   + G T L++A
Sbjct  720   NVRNRKLQSPLHLAVQQAHVGLVPLLVDAGCSVNAEDEEGDTALHVA  766


 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 41/163 (25%), Positives = 65/163 (39%), Gaps = 2/163 (1%)

Query  1009  LLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNG  1068
             LL     QV+  ++ G T L  AA  G  E + LL+   A ++   D G T L+ A    
Sbjct  509   LLRRRPEQVDTKNQ-GRTALQVAAYLGQVELIRLLLQARAGVDLPDDEGNTALHYAALGN  567

Query  1069  NKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeeses  1128
               E  ++LL AG       +   T +H AV  G ++ ++ L       +    + +    
Sbjct  568   QPEATRVLLSAGCRADAINSTQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTPLH  627

Query  1129  sVFDLDGGEESPEGISKPVVPADLINHANREGWTAAHIAASKG  1171
             S      G      +   V   D +   N +G+T  H A+ KG
Sbjct  628   SAISAGTGASGIVEVLTEVPNID-VTATNSQGFTLLHHASLKG  669


>gi|33514905|sp|Q9P2R3|ANFY1_HUMAN  Ankyrin repeat and FYVE domain protein 1 (Ankyrin repeats hooked 
to a zinc finger motif)
Length=1169

 Score = 58.2 bits (139),  Expect = 3e-08
 Identities = 51/176 (28%), Positives = 77/176 (43%), Gaps = 17/176 (9%)

Query  950   GPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINY------------SCEDGHSALYS  997
             GP P     TLL +A  + N      L+   G D+N                DG + L+ 
Sbjct  718   GPGPGGCLQTLLHRAIDENNEPTACFLIRS-GCDVNSPRQPGANGEGEEEARDGQTPLHL  776

Query  998   AAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISY-DANINHAADG  1056
             AA  G  + V+ LL   A VNA D  G TP+  A +  H   ++LL+S+ D ++N     
Sbjct  777   AASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQ  836

Query  1057  GQTPLYLACKNGNKECIKLLL--EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             G TP   A    N +  + +L  E+G    V    G   +H AV   +++S+  L+
Sbjct  837   GLTPFACAMTFKNNKSAEAILKRESGAAEQV-DNKGRNFLHVAVQNSDIESVLFLI  891


 Score = 52.0 bits (123),  Expect = 3e-06
 Identities = 49/201 (24%), Positives = 79/201 (39%), Gaps = 49/201 (24%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L   A Q   +  ++ L E   DIN   +DG +AL  A +N     V  + +  A ++  
Sbjct  625   LLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVP  684

Query  1021  DKNGFTPLCAAAAQ---------------------GHFECVELLISYDANINHA------  1053
             D+ G  PL  A A                      G   C++ L+    + N+       
Sbjct  685   DEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFL  744

Query  1054  ----------------------ADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW  1091
                                   A  GQTPL+LA   G +E ++ LLE G N + +  +G 
Sbjct  745   IRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGR  804

Query  1092  TPVHAAVDTGNVDSLKLLMYH  1112
             TP+H A+ + +   ++LL+ H
Sbjct  805   TPIHVAISSQHGVIIQLLVSH  825


 Score = 50.4 bits (119),  Expect = 7e-06
 Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 2/122 (1%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAA--DKNGFTPLCAAAAQGHFECVELLISYDA  1048
             G + L+ A +N   + V  L+S  A VN+   D +  TPL  A   G    V  L+   A
Sbjct  871   GRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGA  930

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKL  1108
              +N      QT L+LA +        +LLE G + +    +G   +H AV  G ++++++
Sbjct  931   KVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRV  990

Query  1109  LM  1110
             L+
Sbjct  991   LL  992


 Score = 48.9 bits (115),  Expect = 2e-05
 Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 12/131 (9%)

Query  984   INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL  1043
             +N +  +G  AL  A           L+S +A V+  DK+G++ L     +G       L
Sbjct  249   LNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFL  308

Query  1044  ISYDANINHAADGGQ-TPLYLACKNGNK-----------ECIKLLLEAGTNRSVKTTDGW  1091
             I   A +N A  G Q TPL+L     +K           +  + LL+AG N +++ + G 
Sbjct  309   IKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGR  368

Query  1092  TPVHAAVDTGN  1102
             TP+H ++  GN
Sbjct  369   TPLHVSIMAGN  379


 Score = 46.6 bits (109),  Expect = 1e-04
 Identities = 46/182 (25%), Positives = 75/182 (41%), Gaps = 39/182 (21%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  +   GN  + S LL  + LD+     +G +AL+ A ++       + +S++  VN
Sbjct  369   TPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQH-------ITVSSDQSVN  421

Query  1019  -----------AADKNGFTP--------------------LCAAAAQGHFECVELLISYD  1047
                        + D+N F                      L  AA  G+      L +  
Sbjct  422   PFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNG  481

Query  1048  ANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW-TPVHAAVDTGNVDSL  1106
             A++NH    G+TPL+ AC++G       LL+ G N +++T +    P  AA  T   DS+
Sbjct  482   AHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSV  541

Query  1107  KL  1108
              L
Sbjct  542   HL  543


 Score = 45.1 bits (105),  Expect = 3e-04
 Identities = 46/186 (24%), Positives = 72/186 (38%), Gaps = 33/186 (17%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             LLQ+AA  GN    ++ L   G  +N+  + G + L++A ++G  +    LL   A  N 
Sbjct  461   LLQRAAGAGNEAA-ALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNL  519

Query  1020  ADKNGF-------------------TPLCAAAAQGHFECVELLISYDANINHAADG----  1056
               +                      TPL  A A  H + V +++   AN  HA +     
Sbjct  520   QTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQII  579

Query  1057  ---------GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLK  1107
                       QT L LA   G       LL +G   +   +DG T +H A+   +  S  
Sbjct  580   PDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSAL  639

Query  1108  LLMYHR  1113
              L+ H+
Sbjct  640   FLLEHQ  645


 Score = 42.7 bits (99),  Expect = 0.002
 Identities = 46/176 (26%), Positives = 70/176 (39%), Gaps = 38/176 (21%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS-AEAQV  1017
             T L  AA+ G    +  LL E G ++N    +G + ++ A  + H   ++LL+S  +  +
Sbjct  772   TPLHLAASWGLEETVQCLL-EFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHL  830

Query  1018  NAADKNGFTPL-CA---------------------------------AAAQGHFECVELL  1043
             N  D+ G TP  CA                                 A      E V  L
Sbjct  831   NVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFL  890

Query  1044  ISYDANINHAADGGQ--TPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
             IS  AN+N         TPL+LA + G++  ++ LL AG   +  T    T +H A
Sbjct  891   ISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLA  946


 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 40/142 (28%), Positives = 61/142 (42%), Gaps = 11/142 (7%)

Query  957   RPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS-AEA  1015
             R T L  AA Q   T+ S+LL E G+D     E+G++AL+ A  +G  + +R+LL+    
Sbjct  939   RQTALHLAAQQDLPTICSVLL-ENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTV  997

Query  1016  QVNAADKNGFTPLCAAAAQGHFEC-------VELLISYDANINHAADGGQTPLYLACKNG  1068
                A +  G +PL      G           +E +  Y  +   A   G T L LA   G
Sbjct  998   DAEAFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDA--DGSTVLLLAYMKG  1055

Query  1069  NKECIKLLLEAGTNRSVKTTDG  1090
             N    + ++ +G    V    G
Sbjct  1056  NANLCRAIVRSGARLGVNNNQG  1077


 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 40/154 (25%), Positives = 61/154 (39%), Gaps = 15/154 (9%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGH--SALYSAAKNGHTDCVRLLLSAEAQV  1017
             LLQQ A     T  ++ L +E   +    +  H  + L+ A    H D V ++L  +A  
Sbjct  510   LLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANA  569

Query  1018  NAA-------------DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLA  1064
               A             D    T L  A   G       L+   A IN     GQT L++A
Sbjct  570   LHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMA  629

Query  1065  CKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
              +  + +    LLE   + +V+T DG T +  A+
Sbjct  630   IQRQDSKSALFLLEHQADINVRTQDGETALQLAI  663


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 0/103 (0%)

Query  1010  LLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGN  1069
             LL + A +N    +G T L  A  +   +    L+ + A+IN     G+T L LA +N  
Sbjct  608   LLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQL  667

Query  1070  KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                +  +   G + SV    G  P+  A+     D    L+ H
Sbjct  668   PLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRH  710


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 13/136 (9%)

Query  983   DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGF-TPLCAAAAQGH-----  1036
             D++   + G S L+   + G       L+   A VNAA      TPL   A         
Sbjct  281   DVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSA  340

Query  1037  ------FECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEA-GTNRSVKTTD  1089
                    +  E L+   AN N     G+TPL+++   GN+     LL+    +  +K  +
Sbjct  341   DVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHE  400

Query  1090  GWTPVHAAVDTGNVDS  1105
             G T +  AV    V S
Sbjct  401   GSTALWLAVQHITVSS  416


>gi|20138912|sp|P58546|MTPN_HUMAN  Myotrophin (V-1 protein)
Length=118

 Score = 57.8 bits (138),  Expect = 5e-08
 Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 4/99 (4%)

Query  980   EGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFEC  1039
             +G D+N + E G   L+ AA  G  + +  LL   A +NA DK+  TPL +A  +GH  C
Sbjct  24    KGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSC  83

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             V+LL+S  A+       G T    A +  + + IK LL+
Sbjct  84    VKLLLSKGADKTVKGPDGLT----AFEATDNQAIKALLQ  118


 Score = 56.6 bits (135),  Expect = 1e-07
 Identities = 37/99 (37%), Positives = 49/99 (49%), Gaps = 0/99 (0%)

Query  998   AAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGG  1057
             A KNG  D V+  ++    VN   + G  PL  AA  G  E +E L+   A+IN      
Sbjct  9     ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH  68

Query  1058  QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHA  1096
              TPL  A   G+  C+KLLL  G +++VK  DG T   A
Sbjct  69    ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEA  107


 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 23/80 (28%), Positives = 41/80 (51%), Gaps = 0/80 (0%)

Query  1031  AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG  1090
             A   G  + V+  ++   ++N   +GG+ PL+ A   G  E ++ LL  G + +      
Sbjct  9     ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH  68

Query  1091  WTPVHAAVDTGNVDSLKLLM  1110
              TP+ +AV  G+V  +KLL+
Sbjct  69    ITPLLSAVYEGHVSCVKLLL  88


>gi|55976446|sp|Q6S8J7|POTE8_HUMAN  Prostate, ovary, testis expressed protein on chromosome 8
Length=498

 Score = 56.6 bits (135),  Expect = 1e-07
 Identities = 44/150 (29%), Positives = 67/150 (44%), Gaps = 0/150 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G V    +++   G  IN   +   +AL+ A  NG+++ V LLL  + Q++  
Sbjct  69    LHRAAWWGEVPRADLIVMLRGPGINKRDKKKRTALHLACANGNSEVVSLLLDRQCQLHVF  128

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D    T L  A      EC  +L+ +  + N     G T L+ A  N +K   K LL  G
Sbjct  129   DSKKRTALIKAVQCQEDECALMLLQHGTDPNLPDMYGNTALHYAVYNEDKLMAKTLLLYG  188

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              +   K   G TP+  AV       +K L+
Sbjct  189   ADIESKNKGGLTPLLLAVHGQKQRMVKFLI  218


 Score = 54.3 bits (129),  Expect = 5e-07
 Identities = 43/156 (27%), Positives = 66/156 (42%), Gaps = 1/156 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A A GN  ++S+LL+ +   ++       +AL  A +    +C  +LL      N
Sbjct  101   TALHLACANGNSEVVSLLLDRQ-CQLHVFDSKKRTALIKAVQCQEDECALMLLQHGTDPN  159

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D  G T L  A         + L+ Y A+I     GG TPL LA     +  +K L++
Sbjct  160   LPDMYGNTALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIK  219

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI  1114
                N +     G T +  AV  G+   + LL+   I
Sbjct  220   KKANLNALDRFGRTALILAVRCGSASIVSLLLQQNI  255


 Score = 49.7 bits (117),  Expect = 1e-05
 Identities = 37/127 (29%), Positives = 58/127 (45%), Gaps = 0/127 (0%)

Query  974   SMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAA  1033
             +++L + G D N     G++AL+ A  N      + LL   A + + +K G TPL  A  
Sbjct  148   ALMLLQHGTDPNLPDMYGNTALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVH  207

Query  1034  QGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP  1093
                   V+ LI   AN+N     G+T L LA + G+   + LLL+   +   +   G T 
Sbjct  208   GQKQRMVKFLIKKKANLNALDRFGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTA  267

Query  1094  VHAAVDT  1100
                AV +
Sbjct  268   EDYAVSS  274


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 33/133 (24%), Positives = 52/133 (39%), Gaps = 10/133 (7%)

Query  968   GNVTLLSMLLNEE----------GLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             GN  L   + NE+          G DI    + G + L  A        V+ L+  +A +
Sbjct  165   GNTALHYAVYNEDKLMAKTLLLYGADIESKNKGGLTPLLLAVHGQKQRMVKFLIKKKANL  224

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             NA D+ G T L  A   G    V LL+  + ++      GQT    A  + +    +LL 
Sbjct  225   NALDRFGRTALILAVRCGSASIVSLLLQQNIDVFSQDVFGQTAEDYAVSSHHSIICQLLS  284

Query  1078  EAGTNRSVKTTDG  1090
             +   N+    + G
Sbjct  285   DYKENQMPNNSSG  297


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 0/63 (0%)

Query  1050  INHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             IN      +T L+LAC NGN E + LLL+      V  +   T +  AV     +   +L
Sbjct  92    INKRDKKKRTALHLACANGNSEVVSLLLDRQCQLHVFDSKKRTALIKAVQCQEDECALML  151

Query  1110  MYH  1112
             + H
Sbjct  152   LQH  154


>gi|46395884|sp|Q8IUH4|ZDH13_HUMAN  Probable palmitoyltransferase ZDHHC13 (Zinc finger DHHC domain-containing 
protein 13) (DHHC-13) (Huntingtin-interacting protein 
14-related protein) (HIP14-related protein) (Huntingtin-interacting 
protein HIP3RP) (Putative NF-kappa-B-activating 
protein 209) (Putative MAPK-activating protein PM03)
Length=622

 Score = 56.6 bits (135),  Expect = 1e-07
 Identities = 44/146 (30%), Positives = 71/146 (48%), Gaps = 3/146 (2%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A  QG++ ++ +LL + G D      +G S+++ A    H   +  L+S    VN
Sbjct  118   TPLHWAIRQGHLPMVILLL-QHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVN  176

Query  1019  AADKNGFTPLCAAAAQGHF-ECVELLISYDANINHAADGGQ-TPLYLACKNGNKECIKLL  1076
               D NG TPL  +A +    E    L+ ++ ++N      Q TPL+ A   GN   +  L
Sbjct  177   MTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKL  236

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGN  1102
             LEAG++  ++   G TP+  A+   N
Sbjct  237   LEAGSSLDIQNVKGETPLDMALQNKN  262


 Score = 49.3 bits (116),  Expect = 2e-05
 Identities = 46/156 (29%), Positives = 69/156 (44%), Gaps = 6/156 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             +LL  AA    + L+   +++  +      +   + L+ A + GH   V LLL   A   
Sbjct  84    SLLHWAAINNRLDLVRFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPT  143

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL-ACKNGNKECIKLLL  1077
               D  GF+ +  A    H   +  LIS   ++N     GQTPL L A K    E    LL
Sbjct  144   LIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLL  203

Query  1078  EAGTNRSVKTTDGW---TPVHAAVDTGNVDSLKLLM  1110
             +   N S+   D     TP+H AV  GNV+++  L+
Sbjct  204   K--FNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLL  237


>gi|22256977|sp|Q96T49|PP16B_HUMAN  Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta-inhibited 
membrane-associated protein) (hTIMAP) (CAAX box 
protein TIMAP) (Ankyrin repeat domain protein 4)
Length=567

 Score = 56.2 bits (134),  Expect = 1e-07
 Identities = 46/183 (25%), Positives = 78/183 (42%), Gaps = 30/183 (16%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L Q        ++ +LL+  G ++N    +  + L++AA  GH + V++L+   A + 
Sbjct  103   TALHQCCIDNFEEIVKLLLSH-GANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLL  161

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYD-------------------ANINHAADGGQ-  1058
             A + +G  P      +   + +E  ++Y                    A+I+     GQ 
Sbjct  162   AVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQD  221

Query  1059  ---------TPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
                      T L++A  NG     +LLL+ G    VK  DGW P+HAA   G +   +LL
Sbjct  222   LDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELL  281

Query  1110  MYH  1112
             + H
Sbjct  282   VSH  284


 Score = 55.1 bits (131),  Expect = 3e-07
 Identities = 36/116 (31%), Positives = 57/116 (49%), Gaps = 11/116 (9%)

Query  962   QQAAAQGNVTLLSMLLNEEGLDINYSC----------EDGHSALYSAAKNGHTDCVRLLL  1011
             ++ + + +V LL   L  +  ++ Y            EDG +AL+    +   + V+LLL
Sbjct  62    KKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLL  121

Query  1012  SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKN  1067
             S  A VNA D   +TPL AAA  GH   V++L+ Y A++      G  P Y  C++
Sbjct  122   SHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMP-YDLCED  176


 Score = 49.3 bits (116),  Expect = 2e-05
 Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 0/120 (0%)

Query  994   ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHA  1053
             AL  A+     + VR  L  +   +  +++G T L         E V+LL+S+ AN+N  
Sbjct  71    ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAK  130

Query  1054  ADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
              +   TPL+ A   G+   +K+L++ G +     +DG  P     D   +D ++  M ++
Sbjct  131   DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQ  190


 Score = 47.4 bits (111),  Expect = 6e-05
 Identities = 30/97 (30%), Positives = 50/97 (51%), Gaps = 4/97 (4%)

Query  981   GLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECV  1040
             G D+++    G + L+ A  NG+     LLL    +V+  D +G+ PL AAA  G  +  
Sbjct  219   GQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA  278

Query  1041  ELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             ELL+S+ A+++      + P+ L      +E  K+LL
Sbjct  279   ELLVSHGASLSARTSMDEMPIDLC----EEEEFKVLL  311


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 0/88 (0%)

Query  1007  VRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACK  1066
             +  +++A   ++  D  G T L  A A G+    ELL+ +   ++     G  PL+ A  
Sbjct  212   IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAF  271

Query  1067  NGNKECIKLLLEAGTNRSVKTTDGWTPV  1094
              G  +  +LL+  G + S +T+    P+
Sbjct  272   WGQMQMAELLVSHGASLSARTSMDEMPI  299


>gi|20532003|sp|Q9Y574|ASB4_HUMAN  Ankyrin repeat and SOCS box protein 4 (ASB-4)
Length=426

 Score = 56.2 bits (134),  Expect = 1e-07
 Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 3/122 (2%)

Query  993   SALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH  1052
             + L+ +   GH +C+ +LL   A +N    NG TPL  A    + +CV++L    A +N 
Sbjct  77    TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNC  135

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTT--DGWTPVHAAVDTGNVDSLKLLM  1110
              +  G T L+      +  C K L+  G N ++KT   D  TP+H A   G  + +   +
Sbjct  136   YSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYV  195

Query  1111  YH  1112
              H
Sbjct  196   EH  197


 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 40/198 (20%), Positives = 79/198 (39%), Gaps = 17/198 (8%)

Query  922   SCRPGASDSLLVTASGWSPSLTPLLMSGGPA----PLAGRPTLLQQAAAQGNVTLLSMLL  977
             +CRP     L V     +     +L   G       L+G   L         +    ++ 
Sbjct  102   NCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVW  161

Query  978   NEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAA-----  1032
                 +++  + +D  + L++AA  G ++ V   +   A V++ + +  TPL  AA     
Sbjct  162   RGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALR  221

Query  1033  -------AQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSV  1085
                     + H  C  +L+ Y A +N   D  ++PL+ A  N +   + ++LEAG   ++
Sbjct  222   FKEQEYSTEHHLVC-RMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANL  280

Query  1086  KTTDGWTPVHAAVDTGNV  1103
                +G   +   +   +V
Sbjct  281   MDINGCAAIQYVLKVTSV  298


>gi|20141565|sp|P46531|NOTC1_HUMAN  Neurogenic locus notch homolog protein 1 precursor (Notch 1) 
(hN1) (Translocation-associated notch protein TAN-1) [Contains: 
Notch 1 extracellular truncation; Notch 1 intracellular 
domain]
Length=2556

 Score = 56.2 bits (134),  Expect = 1e-07
 Identities = 42/146 (28%), Positives = 71/146 (48%), Gaps = 3/146 (2%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN  1023
             A AQG   +  +L+     D++    DG + L  AA+      +  L+++ A VNA D  
Sbjct  1972  ADAQG---VFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDL  2028

Query  1024  GFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNR  1083
             G + L  AAA  + +   +L+   AN +   +  +TPL+LA + G+ E  K+LL+   NR
Sbjct  2029  GKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANR  2088

Query  1084  SVKTTDGWTPVHAAVDTGNVDSLKLL  1109
              +       P   A +  + D ++LL
Sbjct  2089  DITDHMDRLPRDIAQERMHHDIVRLL  2114


 Score = 50.4 bits (119),  Expect = 7e-06
 Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 2/155 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEA-QV  1017
             T L  AA          LL E   D N     G + L++A         ++L+   A  +
Sbjct  1931  TALHLAARYSRSDAAKRLL-EASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDL  1989

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLL  1077
             +A   +G TPL  AA       +E LI+  A++N   D G++ L+ A    N +   +LL
Sbjct  1990  DARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLL  2049

Query  1078  EAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             + G N+ ++     TP+  A   G+ ++ K+L+ H
Sbjct  2050  KNGANKDMQNNREETPLFLAAREGSYETAKVLLDH  2084


 Score = 44.3 bits (103),  Expect = 5e-04
 Identities = 39/138 (28%), Positives = 60/138 (43%), Gaps = 27/138 (19%)

Query  1003  HTDCVRLLLSAEA-------------QVNAADKNGFTPLCAAAAQG---------HFECV  1040
             H D   L +SA A              VN    +GFTPL  A+  G           E  
Sbjct  1848  HLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDA  1907

Query  1041  ELLIS----YDANINHAADG-GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVH  1095
               +IS      A++++  D  G+T L+LA +    +  K LLEA  + +++   G TP+H
Sbjct  1908  PAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLH  1967

Query  1096  AAVDTGNVDSLKLLMYHR  1113
             AAV        ++L+ +R
Sbjct  1968  AAVSADAQGVFQILIRNR  1985


 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 8/138 (5%)

Query  947   MSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDC  1006
             M  G  PL     L  + A +G   +L  L+N    D+N   + G SAL+ AA   + D 
Sbjct  1993  MHDGTTPLI----LAARLAVEG---MLEDLINSHA-DVNAVDDLGKSALHWAAAVNNVDA  2044

Query  1007  VRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACK  1066
               +LL   A  +  +    TPL  AA +G +E  ++L+ + AN +      + P  +A +
Sbjct  2045  AVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQE  2104

Query  1067  NGNKECIKLLLEAGTNRS  1084
               + + ++LL E    RS
Sbjct  2105  RMHHDIVRLLDEYNLVRS  2122


>gi|1168870|sp|P42773|CDN2C_HUMAN  Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent 
kinase 4 inhibitor C) (p18-INK4c)
Length=168

 Score = 55.5 bits (132),  Expect = 2e-07
 Identities = 35/118 (29%), Positives = 63/118 (53%), Gaps = 2/118 (1%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  AAA+G++  L+ LL +  +++N     G +AL    K G+ +  R LL   A  +  
Sbjct  9     LASAAARGDLEQLTSLL-QNNVNVNAQNGFGRTAL-QVMKLGNPEIARRLLLRGANPDLK  66

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             D+ GF  +  AA  G  + ++ L+ + A++N   + G  PL+LA K G+   ++ L++
Sbjct  67    DRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK  124


 Score = 45.4 bits (106),  Expect = 2e-04
 Identities = 28/83 (33%), Positives = 44/83 (53%), Gaps = 1/83 (1%)

Query  1028  LCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKT  1087
             L +AAA+G  E +  L+  + N+N     G+T L +  K GN E  + LL  G N  +K 
Sbjct  9     LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD  67

Query  1088  TDGWTPVHAAVDTGNVDSLKLLM  1110
               G+  +H A   G +D+L+ L+
Sbjct  68    RTGFAVIHDAARAGFLDTLQTLL  90


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 31/102 (30%), Positives = 43/102 (42%), Gaps = 4/102 (3%)

Query  945   LLMSGGPAPLAGRP--TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNG  1002
             LL+ G    L  R    ++  AA  G +  L  LL  +  D+N    +G+  L+ AAK G
Sbjct  56    LLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQA-DVNIEDNEGNLPLHLAAKEG  114

Query  1003  HTDCVRLLLSAEA-QVNAADKNGFTPLCAAAAQGHFECVELL  1043
             H   V  L+   A  V   +  G T    A   G  E V L+
Sbjct  115   HLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLM  156


>gi|21542418|sp|P19838|NFKB1_HUMAN  Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) 
(EBP-1) [Contains: Nuclear factor NF-kappa-B p50 subunit]
Length=968

 Score = 55.5 bits (132),  Expect = 2e-07
 Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 6/148 (4%)

Query  945   LLMSGGPAPLAGR--PTLLQQAAAQGNVTLLSMLLNEE--GLDINYSCEDGHSALYSAAK  1000
             LL +G    L  R   ++L  AA +G+  +LS+LL  +   L +++   DG +A++ A  
Sbjct  601   LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM  660

Query  1001  NGHTDCVRLLLSAEAQVNAAD-KNGFTPLCAAAAQGHFECVE-LLISYDANINHAADGGQ  1058
             +    C+ LL++A A VNA + K+G T L  A    +      LL+  DA+++     G 
Sbjct  661   SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT  720

Query  1059  TPLYLACKNGNKECIKLLLEAGTNRSVK  1086
             TPL++A   G+     LL  AG +  V+
Sbjct  721   TPLHIAAGRGSTRLAALLKAAGADPLVE  748


 Score = 54.3 bits (129),  Expect = 5e-07
 Identities = 57/216 (26%), Positives = 90/216 (41%), Gaps = 19/216 (8%)

Query  981   GLDINYSCEDGHSALYSAAKNGHTDCVRLLLS---AEAQVNAADKNGFTPLCAAAAQGHF  1037
             G D++     G+S L+ AAK GH   + +LL    A   ++  + +G   +  A      
Sbjct  605   GADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSL  664

Query  1038  ECVELLISYDANIN-HAADGGQTPLYLACKNGNKECIK-LLLEAGTNRSVKTTDGWTPVH  1095
              C+ LL++  A++N      G+T L+LA ++ N      LLLE   +    T DG TP+H
Sbjct  665   PCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLH  724

Query  1096  AAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEES---PEGISKPVVPADL  1152
              A   G+     LL          +    E+   ++DLD   E+    EG+     P D+
Sbjct  725   IAAGRGSTRLAALL------KAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDM  778

Query  1153  INHANREGWTAAHIAASKGFKDCNLPDALLAFSHMR  1188
                     W    I   K ++     D LLA   M+
Sbjct  779   AT-----SWQVFDILNGKPYEPEFTSDDLLAQGDMK  809


 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 10/128 (7%)

Query  993   SALYSAAKNGHTDCVRLLLSAEAQVNAA-DKNGFTPLCAAAAQGHFECVELLISY-----  1046
             +AL+  A  G    V++LL+ +  + A  D+NG + L  A    H + V  L+       
Sbjct  514   NALFDYAVTGD---VKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLI  570

Query  1047  -DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDS  1105
              D  IN   D  QTPL+LA     ++ ++ LL AG + S+    G + +H A   G+   
Sbjct  571   SDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV  630

Query  1106  LKLLMYHR  1113
             L +L+ H+
Sbjct  631   LSILLKHK  638


>gi|22653655|sp|Q92527|ANKR7_HUMAN  Ankyrin repeat domain protein 7 (Testis-specific protein TSA806)
Length=201

 Score = 53.9 bits (128),  Expect = 7e-07
 Identities = 44/152 (28%), Positives = 67/152 (44%), Gaps = 1/152 (0%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L  A A G+  ++  L+ E+   IN    +  S L  A +  + DC  +LL+  A  +
Sbjct  8     TPLHLACANGHTDVVLFLI-EQQCKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPD  66

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
               D    T L  A        VE L+ Y+A++      G TPL +A  N N + +K LLE
Sbjct  67    LRDIRYNTVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLE  126

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G + +       T +  AV       +KLL+
Sbjct  127   KGADVNASDNYQRTALILAVSGEPPCLVKLLL  158


 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 30/98 (30%), Positives = 48/98 (48%), Gaps = 5/98 (5%)

Query  983   DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVEL  1042
             DI Y+     + L+ A        V  LL  EA + A +K+G+TPL  A    + + V+ 
Sbjct  69    DIRYN-----TVLHYAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKF  123

Query  1043  LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             L+   A++N + +  +T L LA        +KLLL+ G
Sbjct  124   LLEKGADVNASDNYQRTALILAVSGEPPCLVKLLLQQG  161


 Score = 41.6 bits (96),  Expect = 0.003
 Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 0/78 (0%)

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             DK   TPL  A A GH + V  LI     IN      ++PL  A +  N++C  +LL  G
Sbjct  3     DKKYRTPLHLACANGHTDVVLFLIEQQCKINVRDSENKSPLIKAVQCQNEDCATILLNFG  62

Query  1081  TNRSVKTTDGWTPVHAAV  1098
              +  ++     T +H AV
Sbjct  63    ADPDLRDIRYNTVLHYAV  80


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 17/53 (32%), Positives = 31/53 (58%), Gaps = 0/53 (0%)

Query  1058  QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             +TPL+LAC NG+ + +  L+E     +V+ ++  +P+  AV   N D   +L+
Sbjct  7     RTPLHLACANGHTDVVLFLIEQQCKINVRDSENKSPLIKAVQCQNEDCATILL  59


>gi|55976444|sp|Q6S5H5|POT14_HUMAN  Prostate, ovary, testis expressed protein on chromosome 14
Length=594

 Score = 53.9 bits (128),  Expect = 7e-07
 Identities = 36/122 (29%), Positives = 59/122 (48%), Gaps = 0/122 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G V    +++  +  D+N   +   +AL+ A+ NG+++ V+LLL    Q+N  
Sbjct  143   LHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNIL  202

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D    T L  A      EC  +L+ +  + N   + G T L+ A  N +K   K LL  G
Sbjct  203   DNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYG  262

Query  1081  TN  1082
              +
Sbjct  263   AD  264


 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 0/90 (0%)

Query  1009  LLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNG  1068
             +++  +  +N  DK   T L  A+A G+ E V+LL+     +N   +  +T L  A +  
Sbjct  158   IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQ  217

Query  1069  NKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
               EC  +LLE GT+ ++    G T +H A+
Sbjct  218   EDECALMLLEHGTDPNIPDEYGNTALHYAI  247


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 25/79 (31%), Positives = 37/79 (46%), Gaps = 0/79 (0%)

Query  1022  KNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGT  1081
             ++G TPL     +   + V+ LI   AN+N     G+T L LA   G+   + LLLE   
Sbjct  356   QHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNI  415

Query  1082  NRSVKTTDGWTPVHAAVDT  1100
             + S +   G T    AV +
Sbjct  416   DVSSQDLSGQTAREYAVSS  434


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 21/82 (25%), Positives = 38/82 (46%), Gaps = 0/82 (0%)

Query  1007  VRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACK  1066
             V+ L+  +A +NA D+ G T L  A   G    V LL+  + +++     GQT    A  
Sbjct  374   VKFLIKKKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVS  433

Query  1067  NGNKECIKLLLEAGTNRSVKTT  1088
             + +    +LL +    + +K +
Sbjct  434   SRHNVICQLLSDYKEKQMLKVS  455


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 19/66 (28%), Positives = 31/66 (46%), Gaps = 0/66 (0%)

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL  1106
             D ++N      +T L+LA  NGN E +KLLL+     ++      T +  AV     +  
Sbjct  163   DTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECA  222

Query  1107  KLLMYH  1112
              +L+ H
Sbjct  223   LMLLEH  228


>gi|85700410|sp|Q9BZ19|CT086_HUMAN  Hypothetical protein C20orf86
Length=240

 Score = 52.8 bits (125),  Expect = 1e-06
 Identities = 29/98 (29%), Positives = 52/98 (53%), Gaps = 1/98 (1%)

Query  1022  KNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGT  1081
             +  F  L  A+ +GHF+ V+ L+ + A+    +  G+TPL++A   G  +CI LLL+ G 
Sbjct  113   QRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGA  172

Query  1082  NRSVKTTDGWTPVHAAVDTGN-VDSLKLLMYHRIPAHG  1118
             +   +   G TP+  A    + +   ++++ HRI   G
Sbjct  173   SIHDRDAKGETPISIAHRLNHTLSERQMVLLHRIAKSG  210


 Score = 51.2 bits (121),  Expect = 4e-06
 Identities = 28/71 (39%), Positives = 40/71 (56%), Gaps = 0/71 (0%)

Query  994   ALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHA  1053
             ALY A+  GH D V+ LL   A   +    G TPL  AAA G  +C+ LL+ + A+I+  
Sbjct  118   ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR  177

Query  1054  ADGGQTPLYLA  1064
                G+TP+ +A
Sbjct  178   DAKGETPISIA  188


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 1/76 (1%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  A+ +G+   +  LL E G         G + L+ AA  G +DC+ LLL   A ++  
Sbjct  119   LYVASHRGHFDAVQYLL-EHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR  177

Query  1021  DKNGFTPLCAAAAQGH  1036
             D  G TP+  A    H
Sbjct  178   DAKGETPISIAHRLNH  193


>gi|34098677|sp|Q96KQ4|ASPP1_HUMAN  Apoptosis stimulating of p53 protein 1 (Protein phosphatase 1 
regulatory subunit 13B)
Length=1090

 Score = 52.4 bits (124),  Expect = 2e-06
 Identities = 30/89 (33%), Positives = 46/89 (51%), Gaps = 3/89 (3%)

Query  1025  FTPLCA---AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGT  1081
             F PL     A+ +G F+ V+ +I    + +   D G TPL+ A   G+   +K LL+ G 
Sbjct  886   FNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGV  945

Query  1082  NRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             N +   +DGWTP+H A    +V   K L+
Sbjct  946   NVNAADSDGWTPLHCAASCNSVHLCKQLV  974


 Score = 47.4 bits (111),  Expect = 6e-05
 Identities = 26/86 (30%), Positives = 40/86 (46%), Gaps = 0/86 (0%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA  1054
             L  A+  G  D V+ ++      +  +  G TPL  A   GH   V+ L+ +  N+N A 
Sbjct  892   LLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAAD  951

Query  1055  DGGQTPLYLACKNGNKECIKLLLEAG  1080
               G TPL+ A    +    K L+E+G
Sbjct  952   SDGWTPLHCAASCNSVHLCKQLVESG  977


 Score = 44.7 bits (104),  Expect = 4e-04
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             LL  A+ +G   L+  ++ E   D +   ++G + L++A   GH   V+ LL     VNA
Sbjct  891   LLLDASLEGEFDLVQRIIYEVE-DPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNA  949

Query  1020  ADKNGFTPL-CAAAAQGHFECVELLIS  1045
             AD +G+TPL CAA+      C +L+ S
Sbjct  950   ADSDGWTPLHCAASCNSVHLCKQLVES  976


>gi|20143880|sp|Q9BXW6|OSBL1_HUMAN  Oxysterol-binding protein-related protein 1 (OSBP-related protein 
1) (ORP-1)
Length=950

 Score = 52.0 bits (123),  Expect = 3e-06
 Identities = 38/113 (33%), Positives = 53/113 (46%), Gaps = 10/113 (8%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNA-ADKN---------GFTPLCAAAAQGHFEC  1039
             +    L   A+NG+ + VR LL   A+    AD N         G+TPL  A   GH + 
Sbjct  4     EAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQV  63

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT  1092
             V+ L+   A +N   D G TPL+ A   G KE + LLLE   + ++    G T
Sbjct  64    VQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQT  116


 Score = 43.5 bits (101),  Expect = 9e-04
 Identities = 22/54 (40%), Positives = 34/54 (62%), Gaps = 0/54 (0%)

Query  1057  GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             G TPL+LAC  G+++ ++ LL+AG   +V    G TP+H A  TG  + + LL+
Sbjct  48    GWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLL  101


 Score = 41.6 bits (96),  Expect = 0.003
 Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 1/70 (1%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGL-DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             LL  AA +G  T L+ LLN     D+N S + G++ L+ AA   H  C   LL + A  N
Sbjct  144   LLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPN  203

Query  1019  AADKNGFTPL  1028
               +KN   PL
Sbjct  204   LKNKNDQKPL  213


 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 35/150 (23%), Positives = 60/150 (40%), Gaps = 29/150 (19%)

Query  977   LNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTP---------  1027
             L + G ++N   + G + L+ AA  G  + V LLL   A     + +G T          
Sbjct  67    LLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEI  126

Query  1028  ------------------LCAAAAQGHFECVELLISYD--ANINHAADGGQTPLYLACKN  1067
                               L AAA +G    +  L++     ++N +   G TPL+ A   
Sbjct  127   RSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYR  186

Query  1068  GNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
              +K+C   LL +G + ++K  +   P+  A
Sbjct  187   AHKQCALKLLRSGADPNLKNKNDQKPLDLA  216


>gi|33860140|sp|Q13625|ASPP2_HUMAN  Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding 
protein 2) (p53-binding protein 2) (53BP2) (Bcl2-binding 
protein) (Bbp)
Length=1128

 Score = 50.8 bits (120),  Expect = 6e-06
 Identities = 29/89 (32%), Positives = 46/89 (51%), Gaps = 3/89 (3%)

Query  1025  FTPLCA---AAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGT  1081
             F PL     ++ +G F+ V+ +I    + +   D G T L+ A   G+ E +K L++ G 
Sbjct  924   FNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGV  983

Query  1082  NRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
             N +   +DGWTP+H A    NV   K L+
Sbjct  984   NVNAADSDGWTPLHCAASCNNVQVCKFLV  1012


 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 1/91 (1%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             LL  ++ +G   L+  ++ E   D +   ++G +AL++A   GHT+ V+ L+     VNA
Sbjct  929   LLLDSSLEGEFDLVQRIIYEVD-DPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNA  987

Query  1020  ADKNGFTPLCAAAAQGHFECVELLISYDANI  1050
             AD +G+TPL  AA+  + +  + L+   A +
Sbjct  988   ADSDGWTPLHCAASCNNVQVCKFLVESGAAV  1018


 Score = 48.1 bits (113),  Expect = 4e-05
 Identities = 26/86 (30%), Positives = 41/86 (47%), Gaps = 0/86 (0%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA  1054
             L  ++  G  D V+ ++      +  +  G T L  A   GH E V+ L+ +  N+N A 
Sbjct  930   LLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAAD  989

Query  1055  DGGQTPLYLACKNGNKECIKLLLEAG  1080
               G TPL+ A    N +  K L+E+G
Sbjct  990   SDGWTPLHCAASCNNVQVCKFLVESG  1015


>gi|39931161|sp|Q8IVF6|ANR18_HUMAN  Ankyrin repeat domain protein 18A
Length=992

 Score = 50.4 bits (119),  Expect = 7e-06
 Identities = 37/157 (23%), Positives = 64/157 (40%), Gaps = 0/157 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             + +AA +G+   +   L     D++       + L+ A  +G    V LLL    Q++  
Sbjct  38    IHRAAIKGDAAEVERCLTRRFRDLDARDRKDRTVLHLACAHGRVQVVTLLLHRRCQIDIC  97

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG  1080
             D+   TPL  A       C  +L+   AN N     G T L+ A  N      + LL   
Sbjct  98    DRLNRTPLMKAVHSQEEACAIVLLECGANPNIKDIYGNTALHYAVYNKGTSLAERLLSHH  157

Query  1081  TNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAH  1117
              N      +G TP+  A+++     ++ L+ ++   H
Sbjct  158   ANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIH  194


 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 37/119 (31%), Positives = 55/119 (46%), Gaps = 0/119 (0%)

Query  974   SMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAA  1033
             +++L E G + N     G++AL+ A  N  T     LLS  A + A +K G TPL  A  
Sbjct  117   AIVLLECGANPNIKDIYGNTALHYAVYNKGTSLAERLLSHHANIEALNKEGNTPLLFAIN  176

Query  1034  QGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT  1092
                   VE L+   ANI+   +  +T L LA ++     + LLL+     S +   G T
Sbjct  177   SRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTLLLQQNIRISSQDMFGQT  235


>gi|57015399|sp|Q15653|IKBB_HUMAN  NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) 
(IKB-beta) (IKB-B) (Thyroid receptor-interacting 
protein 9) (TR-interacting protein 9)
Length=356

 Score = 50.1 bits (118),  Expect = 1e-05
 Identities = 46/160 (28%), Positives = 70/160 (43%), Gaps = 8/160 (5%)

Query  1016  QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG-GQTPLYLACKNGNKECIK  1074
             Q+ A +  G TPL  A      E V LL    A+++      G++PL+LA +    + ++
Sbjct  199   QLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLE  258

Query  1075  LLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPAHGnsfneeesessVFDLD  1134
             LLL AG N + +   G TP+ +A+   N    +LL  H  P       +    SS  D D
Sbjct  259   LLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSD  318

Query  1135  GGEESPEGISKPVVPADLINHANREGWTAAHIAASKGFKD  1174
              G+E  E         D++ H++R         ASK   D
Sbjct  319   SGDEGDE-------YDDIVVHSSRSQTRLPPTPASKPLPD  351


 Score = 47.0 bits (110),  Expect = 8e-05
 Identities = 45/141 (31%), Positives = 60/141 (42%), Gaps = 6/141 (4%)

Query  955   AGRPTLLQQAAAQGNVTLLSML---LNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLL  1011
             +G  +L   AAA G   L + L   L+   L   Y  EDG +AL+ A  + H   +  LL
Sbjct  19    SGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLL  78

Query  1012  SAEAQVNAADKN---GFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNG  1068
                A     D     G T L  AA  G    VE L +  A +  A   G T L+LAC+ G
Sbjct  79    GFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVG  138

Query  1069  NKECIKLLLEAGTNRSVKTTD  1089
                C + LL+    R  +  D
Sbjct  139   AHACARALLQPRPRRPREAPD  159


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 24/83 (28%), Positives = 35/83 (42%), Gaps = 3/83 (3%)

Query  1022  KNGFTPLCAAAAQGHFECVELLISYDANINHAA---DGGQTPLYLACKNGNKECIKLLLE  1078
             ++G T L  A    H   ++ L+ + A   +     D GQT L+LA   G    ++ L  
Sbjct  56    EDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYA  115

Query  1079  AGTNRSVKTTDGWTPVHAAVDTG  1101
             AG    V    G T +H A   G
Sbjct  116   AGAGLCVAERRGHTALHLACRVG  138


>gi|39932727|sp|Q15057|CENB2_HUMAN  Centaurin-beta 2 (Cnt-b2)
Length=778

 Score = 49.7 bits (117),  Expect = 1e-05
 Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 2/122 (1%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAA--DKNGFTPLCAAAAQGHFECVELLISYDANINH  1052
             LY A+   +   +   L+  A VN A  ++N  TPL  A   G     E L+   AN+N 
Sbjct  610   LYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQ  669

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                 G+ PL+ A   G+   + L L+ G N+     +G  P+  AV+  N D + LL   
Sbjct  670   RDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLA  729

Query  1113  RI  1114
             R+
Sbjct  730   RM  731


>gi|1346640|sp|P35580|MYH10_HUMAN  Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin 
heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin 
heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B)
Length=1976

 Score = 49.3 bits (116),  Expect = 2e-05
 Identities = 43/196 (21%), Positives = 93/196 (47%), Gaps = 24/196 (12%)

Query  346   EKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAES----RQKKLEMEKLQLQALEQEHK  401
             E+K +    L     + A  ++M+ R++A+    E      + ++E E+ + Q L+ E K
Sbjct  887   EEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK  946

Query  402   KLAARL--------EEERGKNKQVVLMLVKECK------------QLSGKVIEEAQKLED  441
             K+ A +        EEE  + K  +  +  E K              + K I+E + +ED
Sbjct  947   KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED  1006

Query  442   VMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
              +A+   +  +  E  + L+  + +   M + +E++L + +  R++L     + +  TTD
Sbjct  1007  RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD  1066

Query  502   LKEEIDKMRKMIEQLK  517
             L+++I +++  I++LK
Sbjct  1067  LQDQIAELQAQIDELK  1082


 Score = 46.2 bits (108),  Expect = 1e-04
 Identities = 70/316 (22%), Positives = 133/316 (42%), Gaps = 37/316 (11%)

Query  255   IIISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENAR--  312
             + ++ KK+ ++D      L+ L + +E   +ARD VI+ LR+L+        + E AR  
Sbjct  1614  LAVASKKKMEID------LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS  1667

Query  313   RKEVFIQERYGRFNLND---PFLALQRDYEAGA-----GDKEKKPVC---TNPLSILEAV  361
             R E+F Q +     L       L LQ +  +        ++E+  +    TN  S   A+
Sbjct  1668  RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSAL  1727

Query  362   MAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG---KNKQVV  418
             +   ++++ R++      E  Q  +E+   + +    +   L A L  ER    K+    
Sbjct  1728  LDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR  1787

Query  419   LMLVKECKQLSGKVIE----EAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM  474
               L ++ K+L  K+ E       K +  ++ LE +  +  E  E+ + E+  + ++  + 
Sbjct  1788  QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT  1847

Query  475   EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR----GSDSKPSLSLPR  530
             EK+L E   + E        E  H    KE+++K    ++QLKR      +     +  R
Sbjct  1848  EKKLKEIFMQVED-------ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR  1900

Query  531   KTKDRRLVSISVGTEG  546
             +   R L   +   EG
Sbjct  1901  RKLQRELDDATEANEG  1916


 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 56/247 (22%), Positives = 107/247 (43%), Gaps = 16/247 (6%)

Query  280   MEGELE-ARDLVIEALRE-LKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRD  337
             +E +L+  ++L+ E  R+ L   + I+  + E    +E   +E   R NL    LALQ  
Sbjct  1313  LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ  1372

Query  338   YEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQ---  394
                 A  K+K       +  LE       K  E +S +L        KLE  K +LQ   
Sbjct  1373  L---ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL  1429

Query  395   ---ALEQEHKK-LAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeek  450
                 ++ +H++ +A+ LE+++ K  Q    L+ E K +S +  EE  + E    + E + 
Sbjct  1430  DDLTVDLDHQRQVASNLEKKQKKFDQ----LLAEEKSISARYAEERDRAEAEAREKETKA  1485

Query  451   kktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMR  510
                    EE    K        Q+   + +  + ++ +   ++  E     L++++++MR
Sbjct  1486  LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR  1545

Query  511   KMIEQLK  517
               +E+L+
Sbjct  1546  TQLEELE  1552


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 50/235 (21%), Positives = 107/235 (45%), Gaps = 32/235 (13%)

Query  366   KKMQ---ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLV  422
             KKMQ   + +  QL   E  ++KL++EK+  +A  ++ ++    LE++  K  +   ++ 
Sbjct  946   KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME  1005

Query  423   KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME-----------  471
                 + S ++ EE +K +++     +++   ++LEE L  E++   E+E           
Sbjct  1006  DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT  1065

Query  472   ------AQMEKQLSEFDTE----REQLRAKLNR---EEAHTTDLKEEIDKMRKMIEQLKR  518
                   A+++ Q+ E   +     E+L+  L R   E  H  +  + + +++  I +L+ 
Sbjct  1066  DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE  1125

Query  519   GSDS-KPSLSLPRKTK---DRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKL  569
               +S K S +   K K      L ++    E T+  + A Q +L T+    + +L
Sbjct  1126  DFESEKASRNKAEKQKRDLSEELEALKTELEDTLD-TTAAQQELRTKREQEVAEL  1179


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 59/297 (19%), Positives = 121/297 (40%), Gaps = 28/297 (9%)

Query  285   EARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGD  344
             E + L+I+ +REL+       A+ E+ R++         +  ++   L  Q +    A D
Sbjct  1589  EKKRLLIKQVRELE-------AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARD  1641

Query  345   KEKKPV--CTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKK  402
             +  K +      +   +  +   +  ++ + AQ   +E + K LE E LQLQ      ++
Sbjct  1642  EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER  1701

Query  403   LAARLEEERGKNKQVVL-------MLVKECKQLSGKVIEEAQKLEDV---MAkleeekkk  452
                  E+ER +    +         L+ E ++L  ++ +  ++LE+    M  L +  +K
Sbjct  1702  ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK  1761

Query  453   tneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNR-EEAHTTDLKEEIDKMRK  511
             T    + L+AE         + +    + + + ++L+AKL   E A  +  K  I  +  
Sbjct  1762  TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEA  1821

Query  512   MIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKK  568
              I QL+          L ++ K+R   +  V       + +  Q +    +AD  K+
Sbjct  1822  KIGQLEE--------QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKE  1870


>gi|55976442|sp|Q6S545|POT22_HUMAN  Prostate, ovary, testis expressed protein on chromosome 22
Length=288

 Score = 49.3 bits (116),  Expect = 2e-05
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 0/107 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L +AA  G V    +++  +  D+N   +   +AL+ A+ NG+++ V+LLL    Q+N  
Sbjct  180   LHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVL  239

Query  1021  DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKN  1067
             D    T L  A      EC  +L+ +  + N   + G T L+ A  N
Sbjct  240   DNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYN  286


 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 0/90 (0%)

Query  1009  LLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNG  1068
             +++  +  +N  DK   T L  A+A G+ E V+LL+     +N   +  +T L  A +  
Sbjct  195   IVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALTKAVQCQ  254

Query  1069  NKECIKLLLEAGTNRSVKTTDGWTPVHAAV  1098
               EC  +LLE GT+ ++    G T +H A+
Sbjct  255   EDECALMLLEHGTDPNIPDEYGNTALHYAI  284


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 0/66 (0%)

Query  1047  DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL  1106
             D ++N      +T L+LA  NGN E +KLLL+     +V      T +  AV     +  
Sbjct  200   DTDMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNKKRTALTKAVQCQEDECA  259

Query  1107  KLLMYH  1112
              +L+ H
Sbjct  260   LMLLEH  265


>gi|11135426|sp|Q9Y6H5|SNCAP_HUMAN  Synphilin-1 (Alpha-synuclein-interacting protein)
Length=919

 Score = 48.9 bits (115),  Expect = 2e-05
 Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 3/90 (3%)

Query  958   PTLLQQAAAQGNVTLLSMLLN---EEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAE  1014
             P+L+  A   G   +L  LL    E+G+ ++   +DG+SA++ A+++G+  C++ L+   
Sbjct  421   PSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYG  480

Query  1015  AQVNAADKNGFTPLCAAAAQGHFECVELLI  1044
             A V   +  G  P  +A  QGH  C   L+
Sbjct  481   ANVTMQNHAGEKPSQSAERQGHTLCSRYLV  510


 Score = 45.1 bits (105),  Expect = 3e-04
 Identities = 42/152 (27%), Positives = 68/152 (44%), Gaps = 10/152 (6%)

Query  967   QGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLL--LSAEAQVNAADKNG  1024
             +G ++LL  L   + LD  +  E+G++ L+ AA  GH +C++ L  L  E  +N  +   
Sbjct  328   EGQISLLPHLA-ADNLDKIHD-ENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEK  385

Query  1025  FTPLCAAAAQGHFECVELLISYD---ANINHAADGGQTPLYLACKNGNKECIKLL---LE  1078
              TP   A   G  ECV  ++S     A ++ + D      Y  C    K  + LL    E
Sbjct  386   LTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQE  445

Query  1079  AGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
              G +      DG + VH A   G +  ++ L+
Sbjct  446   QGISLDEVDQDGNSAVHVASQHGYLGCIQTLV  477


 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 36/166 (21%), Positives = 63/166 (37%), Gaps = 40/166 (24%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGLD-INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV-  1017
             LL  AA+QG+   L  L +  G D +N    +  +    A KNG  +CVR ++S    + 
Sbjct  353   LLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIA  412

Query  1018  --------------------------------------NAADKNGFTPLCAAAAQGHFEC  1039
                                                   +  D++G + +  A+  G+  C
Sbjct  413   ELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGC  472

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSV  1085
             ++ L+ Y AN+      G+ P   A + G+  C + L+   T  S+
Sbjct  473   IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSL  518


>gi|20531994|sp|Q8WXK2|ASB14_HUMAN  Ankyrin repeat and SOCS box protein 14 (ASB-14)
Length=302

 Score = 48.5 bits (114),  Expect = 3e-05
 Identities = 32/103 (31%), Positives = 51/103 (49%), Gaps = 12/103 (11%)

Query  1019  AADKNGFTPLCAAAAQGHFECVELLISYDANIN---------HAADGGQTPLYLACKNGN  1069
             A  ++G +P+  AAA  H +C+ELLI    ++N         H  D  ++ LY A  N +
Sbjct  24    AIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSD  83

Query  1070  KECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                +KLLL AG   ++   D    +  A+  GN + + LL+ H
Sbjct  84    LSSVKLLLSAG---ALPNQDPVNCLQIALRMGNYELISLLLRH  123


 Score = 43.5 bits (101),  Expect = 9e-04
 Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 13/98 (13%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCE-------DGH--SALYSAAKNGHTDCVRLLLSAE  1014
             AAA  +   L +L+ + G D+N+  +       D H  SALY A  N     V+LLLSA 
Sbjct  36    AAAGAHPQCLELLI-QAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAG  94

Query  1015  AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH  1052
             A  N    N    L  A   G++E + LL+ + AN+N+
Sbjct  95    ALPNQDPVN---CLQIALRMGNYELISLLLRHGANVNY  129


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 33/106 (31%), Positives = 45/106 (42%), Gaps = 18/106 (16%)

Query  989   EDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA---------DKNGFTPLCAAAAQGHFEC  1039
             + G S ++ AA   H  C+ LL+ A   VN           D +  + L  A +      
Sbjct  27    QSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSS  86

Query  1040  VELLISYDANINHAADGGQTP---LYLACKNGNKECIKLLLEAGTN  1082
             V+LL+S  A  N      Q P   L +A + GN E I LLL  G N
Sbjct  87    VKLLLSAGALPN------QDPVNCLQIALRMGNYELISLLLRHGAN  126


>gi|3183210|sp|Q15027|CENB1_HUMAN  Centaurin-beta 1 (Cnt-b1)
Length=740

 Score = 48.1 bits (113),  Expect = 4e-05
 Identities = 30/93 (32%), Positives = 44/93 (47%), Gaps = 1/93 (1%)

Query  1017  VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLL  1076
             VN    N  TPL  A A       E L+   AN+N A   G+ PL+ A   G+     L 
Sbjct  601   VNGGQDNA-TPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLF  659

Query  1077  LEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             L+ G +   + ++G  P+  A++T N D + LL
Sbjct  660   LKRGADLGARDSEGRDPLTIAMETANADIVTLL  692


>gi|6166599|sp|P35579|MYH9_HUMAN  Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin 
heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin 
heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A)
Length=1960

 Score = 47.8 bits (112),  Expect = 5e-05
 Identities = 42/153 (27%), Positives = 70/153 (45%), Gaps = 24/153 (15%)

Query  359  EAVMAHCKKMQERMSAQLAAA------ESRQKKLEMEKLQLQALEQEHKKLAARLEEERG  412
            E +MA  +++ +    QLAA       E+ Q +L  EKLQLQ   Q   +L A  EE R 
Sbjct  845  EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA  904

Query  413  KNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEA  472
            +       L + C  L  +V EE ++ + +                   AEK++  +   
Sbjct  905  RLTAKKQELEEICHDLEARVEEEEERCQHL------------------QAEKKKMQQNIQ  946

Query  473  QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEE  505
            ++E+QL E ++ R++L+ +    EA    L+EE
Sbjct  947  ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE  979


 Score = 47.0 bits (110),  Expect = 8e-05
 Identities = 44/160 (27%), Positives = 82/160 (51%), Gaps = 21/160 (13%)

Query  361   VMAHCKKMQER---MSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
             + A  KKMQ+    +  QL   ES ++KL++EK+  +A      KL  +LEEE     Q+
Sbjct  934   LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA------KL-KKLEEE-----QI  981

Query  418   VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
             +L      +  + K+ +E + LED +A+      +  E  + L+  K +   M   +E++
Sbjct  982   IL------EDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEER  1035

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
             L   + +R++L     + E  +TDL ++I +++  I +LK
Sbjct  1036  LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELK  1075


 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 45/180 (25%), Positives = 82/180 (45%), Gaps = 12/180 (6%)

Query  364   HCKKMQERMSAQLAAAESRQKKLEMEKLQ--LQALEQEHKKLAARLEEERGKNKQVVLML  421
             +CK  +E+   +   AE      E E+    L  L+ +H+ +   LEE   + ++    L
Sbjct  987   NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQEL  1046

Query  422   VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ--------  473
              K  ++L G   + + ++ ++ A++ E K +  + EEEL A   R  E  AQ        
Sbjct  1047  EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI  1106

Query  474   --MEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRK  531
               +E Q+SE   + E  RA  N+ E    DL EE++ ++  +E     + ++  L   R+
Sbjct  1107  RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE  1166


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 65/276 (23%), Positives = 116/276 (42%), Gaps = 57/276 (20%)

Query  271   SELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDP  330
             +EL+M L+  E EL+A      AL  ++     K    +  R  E  I E          
Sbjct  1072  AELKMQLAKKEEELQA------ALARVEEEAAQKNMALKKIRELESQISE----------  1115

Query  331   FLALQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQERMSAQLAAAESRQKKLEME  389
                LQ D E+    + K       L   LEA+    +   +  +AQ      R++++ + 
Sbjct  1116  ---LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL  1172

Query  390   K-----------LQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQK  438
             K            Q+Q + Q+H +    L E+  + K+V   L K  + L  +  E A +
Sbjct  1173  KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE  1232

Query  439   LEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAH  498
             ++ ++              +  S  KR+  ++EAQ+++   +F+ E E++R +L  +   
Sbjct  1233  VKVLL------------QGKGDSEHKRK--KVEAQLQELQVKFN-EGERVRTELADK---  1274

Query  499   TTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
              T L+ E+D +  ++ Q    SDSK S    + TKD
Sbjct  1275  VTKLQVELDNVTGLLSQ----SDSKSS----KLTKD  1302


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 71/337 (21%), Positives = 134/337 (39%), Gaps = 54/337 (16%)

Query  260   KKEFDVDTLSKSELRMLLSVMEGELEA----RDLVIEALRELKWFTGIKTAKWE----NA  311
             +K+  +   ++ +L M L  +E  +++    RD  I+ LR+L+    +K    E     A
Sbjct  1602  RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ--AQMKDCMRELDDTRA  1659

Query  312   RRKEVFIQERYGRFNLNDPFLAL-QRDYEAGAGDKEKKPVCTNPLSILEAVM------AH  364
              R+E+  Q +     L      + Q   E  A ++ K+        + + +       A 
Sbjct  1660  SREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL  1719

Query  365   CKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEE-------ERG---KN  414
               + + R+ A++A  E   ++LE E+   + +    KK   ++++       ER    KN
Sbjct  1720  ALEEKRRLEARIAQLE---EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKN  1776

Query  415   KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEA--  472
             +     L ++ K+L  K+    Q++E  +                 S  K   T +EA  
Sbjct  1777  ENARQQLERQNKELKVKL----QEMEGTVK----------------SKYKASITALEAKI  1816

Query  473   -QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRK  531
              Q+E+QL     ER+    ++ R E    D+  ++D  R+  EQ K  +D K S  L + 
Sbjct  1817  AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD-KASTRLKQL  1875

Query  532   TKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKK  568
              +                R +  + +  TE AD M +
Sbjct  1876  KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNR  1912


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 66/290 (22%), Positives = 114/290 (39%), Gaps = 44/290 (15%)

Query  271   SELRMLLSVMEGELE-ARDLVIEALRE-LKWFTGIKTAKWENARRKEVFIQERYGRFNLN  328
             S+L    S +E +L+  ++L+ E  R+ L   T +K  + E    +E   +E   + NL 
Sbjct  1297  SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE  1356

Query  329   DPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEM  388
                  L       A  K+K       L   E V    +K  E +S +     +   KLE 
Sbjct  1357  KQIATLHAQV---ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK  1413

Query  389   EKLQLQA------LEQEHKKLAA-RLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLE-  440
              K +LQ       ++ +H++ +A  LE+++ K  Q    L+ E K +S K  EE  + E 
Sbjct  1414  TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ----LLAEEKTISAKYAEERDRAEA  1469

Query  441   -------DVMAkleeekkktneleeelSAEKRRSTEMEAQM-------------------  474
                      ++     ++   +  E     K+  TEME  M                   
Sbjct  1470  EAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA  1529

Query  475   -EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
              E+Q+ E  T+ E+L  +L   E     L+  +  M+   E+  +G D +
Sbjct  1530  LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ  1579


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 66/304 (21%), Positives = 129/304 (42%), Gaps = 33/304 (10%)

Query  270   KSELRMLLSVMEGELEARDLVIEALRELKWFTGI--KTAKWENARRKEVFIQERYGRFNL  327
             + EL+  L+ +E E   +++ ++ +REL+       +  + E A R +   Q+R    +L
Sbjct  1082  EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR----DL  1137

Query  328   NDPFLALQRDYE----AGAGDKEKKPVCTNPLSIL-----EAVMAHCKKMQERMSAQLAA  378
              +   AL+ + E    + A  +E +      ++IL     E    H  ++QE       A
Sbjct  1138  GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQA  1197

Query  379   AESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVK---ECKQLSGKVIEE  435
              E   ++LE  K     LE    K    LE ERG+    V +L++   + +    KV  +
Sbjct  1198  VEELAEQLEQTKRVKANLE----KAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ  1253

Query  436   AQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKL---  492
              Q+L+    + E  + +  +   +L  E    T + +Q + + S+   +   L ++L   
Sbjct  1254  LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT  1313

Query  493   -------NREEAH-TTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGT  544
                    NR++   +T LK+  D+     EQL+   ++K +L     T   ++  +    
Sbjct  1314  QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM  1373

Query  545   EGTV  548
             E +V
Sbjct  1374  EDSV  1377


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 52/246 (21%), Positives = 101/246 (41%), Gaps = 38/246 (15%)

Query  304   KTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMA  363
             K A ++   + +  +Q+      L+D  + L    ++    ++K+      L+  + + A
Sbjct  1404  KVAAYDKLEKTKTRLQQE-----LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA  1458

Query  364   HCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQE------HKKLAARLEE--------  409
               K  +ER  A+  A E   K L + +   +A+EQ+      +K+    +E+        
Sbjct  1459  --KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV  1516

Query  410   -----ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDV-MAkleeekkktneleeelSAE  463
                  E  K+K+ +   V+E K    ++ +E Q  ED  +      +    + E +L   
Sbjct  1517  GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR  1576

Query  464   KRRSTEMEAQMEKQLSEFDTEREQLR-------AKLNREEAHTTDLKEEIDKMRK----M  512
               +S E + Q+ +Q+ E + E E  R       A   + E    DL+  ID   K     
Sbjct  1577  DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA  1636

Query  513   IEQLKR  518
             I+QL++
Sbjct  1637  IKQLRK  1642


>gi|77432385|sp|O00522|KRIT1_HUMAN  Krev interaction trapped protein 1 (Krev interaction trapped 
1) (Cerebral cavernous malformations 1 protein)
Length=736

 Score = 47.8 bits (112),  Expect = 5e-05
 Identities = 38/124 (30%), Positives = 62/124 (50%), Gaps = 6/124 (4%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS-AEAQVNA  1019
             L ++A +G+  LLS LL+E    +N    D  + ++ A   G  +  R+LL   +   N 
Sbjct  292   LHRSACEGDSELLSRLLSER-FSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL  350

Query  1020  ADKNGFTPLCAAAAQGHFECVELLISYDANINHAAD-GGQTPLYLACKNGN---KECIKL  1075
              +    +PL  AA  GH E V++L+++     H  D  G++PL +  +N     +E  KL
Sbjct  351   LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKL  410

Query  1076  LLEA  1079
             L EA
Sbjct  411   LKEA  414


 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 24/87 (27%), Positives = 44/87 (50%), Gaps = 1/87 (1%)

Query  1027  PLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG-TNRSV  1085
             PL  +A +G  E +  L+S   ++N        P++ AC  G  E  ++LLE G  N ++
Sbjct  291   PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL  350

Query  1086  KTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
                   +P+H A   G+ + +++L+ H
Sbjct  351   LNGQLSSPLHFAAGGGHAEIVQILLNH  377


>gi|68565930|sp|Q9BQG2|NUD12_HUMAN  Peroxisomal NADH pyrophosphatase NUDT12 (Nucleoside diphosphate-linked 
moiety X motif 12) (Nudix motif 12)
Length=462

 Score = 47.0 bits (110),  Expect = 8e-05
 Identities = 33/109 (30%), Positives = 56/109 (51%), Gaps = 10/109 (9%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN  1023
             +AA+G++  L+ +L+     +N + E+G +AL  AA+NGH + V+ LL      +  +K+
Sbjct  19    SAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPEIVQFLLEKGCDRSIVNKS  78

Query  1024  GFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKEC  1072
               T L  A   G+         + AN+   A GG+ P +L   N  +EC
Sbjct  79    RQTALDIAVFWGY--------KHIANLLATAKGGKKPWFLT--NEVEEC  117


 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 23/77 (29%), Positives = 40/77 (51%), Gaps = 1/77 (1%)

Query  1026  TPLCAAAAQGHFECVELLISYDANI-NHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS  1084
             T    +AA+G    +  ++S+  ++ N  ++ G T L  A +NG+ E ++ LLE G +RS
Sbjct  14    TQFHCSAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPEIVQFLLEKGCDRS  73

Query  1085  VKTTDGWTPVHAAVDTG  1101
             +      T +  AV  G
Sbjct  74    IVNKSRQTALDIAVFWG  90


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 0/83 (0%)

Query  997   SAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG  1056
             SAA+        +L  + + +N   +NG+T L  AA  GH E V+ L+    + +     
Sbjct  19    SAAEGDIAKLTGILSHSPSLLNETSENGWTALMYAARNGHPEIVQFLLEKGCDRSIVNKS  78

Query  1057  GQTPLYLACKNGNKECIKLLLEA  1079
              QT L +A   G K    LL  A
Sbjct  79    RQTALDIAVFWGYKHIANLLATA  101


>gi|41688801|sp|Q9NWX5|ASB6_HUMAN  Ankyrin repeat and SOCS box protein 6 (ASB-6)
Length=421

 Score = 46.2 bits (108),  Expect = 1e-04
 Identities = 44/138 (31%), Positives = 69/138 (50%), Gaps = 13/138 (9%)

Query  966   AQGNVTLLSMLLNEEGLDINYSCEDG---HSALYSAAKNGHTDCVRLLLSAEAQVNAADK  1022
             A+  +T  + +L   G ++N+  ED    ++AL+ A      D V LL+   A VN  D+
Sbjct  77    AELGLTRAADVLLRHGANLNF--EDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDR  134

Query  1023  -NGFTPLCAAAAQGH-FECVELLISYDANINHAADGGQTPLY--LACKNG----NKECIK  1074
              +  +PL  A+ +     C++ L+   A++N A   G+T L   LA  +G    N E I+
Sbjct  135   IHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIR  194

Query  1075  LLLEAGTNRSVKTTDGWT  1092
             LLLE G +    T DG T
Sbjct  195   LLLEGGADVKATTKDGDT  212


>gi|126682|sp|P25963|IKBA_HUMAN  NF-kappa-B inhibitor alpha (Major histocompatibility complex 
enhancer-binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) 
(IKB-alpha)
Length=317

 Score = 45.8 bits (107),  Expect = 2e-04
 Identities = 33/110 (30%), Positives = 56/110 (50%), Gaps = 7/110 (6%)

Query  991   GHSALYSAAKNGHTDCVRLLLSA------EAQVNAADKNGFTPLCAAAAQGHFECVELLI  1044
             G++ L+ A + G    V +L  +       + + A + NG T L  A+  G+   VELL+
Sbjct  144   GNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLV  203

Query  1045  SYDANIN-HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP  1093
             S  A++N      G+T L+LA    N + + LLL+ G + +  T  G++P
Sbjct  204   SLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSP  253


 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 26/75 (34%), Positives = 40/75 (53%), Gaps = 1/75 (1%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK-NGFTPLCAAAAQGHFECVELLISYDA  1048
             +GH+ L+ A+ +G+   V LL+S  A VNA +  NG T L  A    + + V LL+   A
Sbjct  182   NGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGA  241

Query  1049  NINHAADGGQTPLYL  1063
             ++N     G +P  L
Sbjct  242   DVNRVTYQGYSPYQL  256


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 0/52 (0%)

Query  1058  QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLL  1109
             QTPL+LA      E  + LL AG +  ++   G TP+H A + G + S+ +L
Sbjct  112   QTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVL  163


>gi|34222508|sp|Q15075|EEA1_HUMAN  Early endosome antigen 1 (Endosome-associated protein p162) (Zinc 
finger FYVE domain-containing protein 2)
Length=1411

 Score = 45.4 bits (106),  Expect = 2e-04
 Identities = 41/214 (19%), Positives = 94/214 (43%), Gaps = 25/214 (11%)

Query  365  CKKMQERMSA----------QLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKN  414
            C+++Q R+SA          +L+      +KL+ E  +++   Q  K    +L+++R + 
Sbjct  346  CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK  405

Query  415  KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM  474
            +Q  L L  E  QL  K++E  ++L +   +L                +++ S+E     
Sbjct  406  EQHGLQLQSEINQLHSKLLETERQLGEAHGRL--------------KEQRQLSSEKLMDK  451

Query  475  EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
            E+Q+++   +  +L  +L  +  ++T+L+ ++DK ++   Q ++      +  L     D
Sbjct  452  EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ-HQEQQALQQSTTAKLREAQND  510

Query  535  RRLVSISVGTEGTVTRSVACQTDLVTENADHMKK  568
               V   +G +    +++        EN   ++K
Sbjct  511  LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK  544


 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 44/201 (21%), Positives = 94/201 (46%), Gaps = 21/201 (10%)

Query  359  EAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVV  418
            E +   CKK+Q + ++  A     + +L     ++    QE +KL + + E   KN+ + 
Sbjct  249  EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT  308

Query  419  LMLVK---ECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSA----------EKR  465
              L+K   +  +L  K  EE+   +++ A L ++     +L+  LSA          E  
Sbjct  309  ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELS  368

Query  466  RSTEMEAQMEKQLSEFDTEREQLRAKLNR-------EEAHTTDLKEEIDKMR-KMIEQLK  517
               E   +++++LSE +T+ + L+A+  +       +E H   L+ EI+++  K++E  +
Sbjct  369  EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER  428

Query  518  RGSDSKPSLSLPRKTKDRRLV  538
            +  ++   L   R+    +L+
Sbjct  429  QLGEAHGRLKEQRQLSSEKLM  449


 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 62/279 (22%), Positives = 114/279 (40%), Gaps = 27/279 (9%)

Query  258  SRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENA----RR  313
            S  KE+    LS  +    L     +LEA  L ++A +E +    ++  +  N     R 
Sbjct  709  SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE-QALQDLQQQRQLNTDLELRA  767

Query  314  KEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSIL----EAVMAHCKKMQ  369
             E+  Q    +  ++   L LQ+  EA    K+K         IL    E +    K   
Sbjct  768  TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH  827

Query  370  ERMSAQLAAAESRQKKLEMEKL-----------QLQALEQEHKKLAARLEEERGKNKQVV  418
            E ++ ++    +  +K++MEK            +L  +    K   +  E+E  K K  +
Sbjct  828  EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI  887

Query  419  LMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQL  478
            L L K CK+L  ++  + +       +L++  +K  E   +L  E     E   Q +  L
Sbjct  888  LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL  947

Query  479  SEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
             + + E +QL+  +N       +LK+  ++ +K IE L+
Sbjct  948  KQNEKEEQQLQGNIN-------ELKQSSEQKKKQIEALQ  979


 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 58/250 (23%), Positives = 107/250 (42%), Gaps = 22/250 (8%)

Query  349  PVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLE  408
            P C   L   + +  H + + +  +      ES    L +++  +  L QE + L A L+
Sbjct  44   PQCMKSLGSADELFKHYEAVHDAGNDSGHGGESN---LALKRDDVTLLRQEVQDLQASLK  100

Query  409  EERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRST  468
            EE+  +++    L KE ++  G   +EA K + ++     E +   +  EE   E     
Sbjct  101  EEKWYSEE----LKKELEKYQGLQQQEA-KPDGLVTDSSAELQSLEQQLEEAQTENFNIK  155

Query  469  EMEAQMEKQLSEFDTEREQLRAKLNRE-------EAHTTDLKEEIDKMRKMIEQLKRGSD  521
            +M+   E++ ++  TE   +++K + E       E   T L EE++K   +I+ LK    
Sbjct  156  QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELL  215

Query  522  SKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTEN-ADHMKKLPLTMPVKPSTG  580
             +P +      K + LV +      T+  ++  + +  +E   D  KKL        +T 
Sbjct  216  QRPGIEDVAVLK-KELVQVQ-----TLMDNMTLERERESEKLKDECKKLQSQYASSEATI  269

Query  581  SPLVSANAKG  590
            S L S  AKG
Sbjct  270  SQLRSELAKG  279


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 45/208 (21%), Positives = 95/208 (45%), Gaps = 10/208 (4%)

Query  367   KMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECK  426
             K ++++  +  A +  QK+   + L+ + L  E  KLA  +EE + + ++ +  L +E K
Sbjct  1093  KKEQQLQERCKALQDIQKE---KSLKEKELVNEKSKLA-EIEEIKCRQEKEITKLNEELK  1148

Query  427   QLSGKVIEEAQKLEDVMAkleeekkktneleeelSA----EKRRSTEMEAQMEKQLSEFD  482
                 + I+E   L+D    L ++K +     + L A    EKR    ++ Q++K+  E  
Sbjct  1149  SHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK  1208

Query  483   TEREQLRAKLNRE-EAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSIS  541
              E  +  AKL+ E +     +K+  +   K+  Q+   +++  ++    ++  RR+  + 
Sbjct  1209  KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE  1268

Query  542   VGTEGTVTRSVACQTDLVTENADHMKKL  569
               T+  +   +A     V  N D  + L
Sbjct  1269  KQTD-DLRGEIAVLEATVQNNQDERRAL  1295


>gi|61218305|sp|Q8N961|ABTB2_HUMAN  Ankyrin repeat and BTB/POZ domain-containing protein 2
Length=839

 Score = 45.1 bits (105),  Expect = 3e-04
 Identities = 37/135 (27%), Positives = 57/135 (42%), Gaps = 20/135 (14%)

Query  968   GNVTLLSMLLNEEGLD-INYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA------  1020
             G   L++  +   G D +N   + G + L  A   G    V++L+ A A ++        
Sbjct  312   GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP  371

Query  1021  -------DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGG------QTPLYLACKN  1067
                    D   +T L  A   GH   V+LL+   A++  +A  G      +TPL LA   
Sbjct  372   RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA  431

Query  1068  GNKECIKLLLEAGTN  1082
             GN E + LLL  G +
Sbjct  432   GNYELVSLLLSRGAD  446


 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 37/130 (28%), Positives = 54/130 (41%), Gaps = 21/130 (16%)

Query  1002  GHTDCVRLLLSAEAQ--VNAADKNGFTPLCAAAAQGHFECVELLISYDANIN--------  1051
             G TD +   + A     VN  D  G TPL  A A G    V++LI   AN++        
Sbjct  312   GRTDLINQAIEALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSNSP  371

Query  1052  -----HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGW------TPVHAAVDT  1100
                  H      T L  A  +G+   ++LLL+AG +      +G       TP+  A   
Sbjct  372   RHPSIHPDSRHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNGGEDSYAETPLQLASAA  431

Query  1101  GNVDSLKLLM  1110
             GN + + LL+
Sbjct  432   GNYELVSLLL  441


>gi|22654255|sp|Q00653|NFKB2_HUMAN  Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) 
(H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene 
Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 
subunit]
Length=899

 Score = 44.7 bits (104),  Expect = 4e-04
 Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 15/127 (11%)

Query  1002  GHTDCVRLLLSAEAQV-NAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGG---  1057
             G T   R LL+ +  +  A D+NG TPL  A   G    +E ++     I+HA D G   
Sbjct  465   GVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYV---IHHAQDLGVVN  521

Query  1058  ------QTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAV--DTGNVDSLKLL  1109
                   QTPL+LA   G    +  LL  G + ++    G + +H A+    G  + L+ L
Sbjct  522   LTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRAL  581

Query  1110  MYHRIPA  1116
             +    PA
Sbjct  582   LQSGAPA  588


 Score = 42.7 bits (99),  Expect = 0.002
 Identities = 45/161 (27%), Positives = 71/161 (44%), Gaps = 10/161 (6%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSA--AKNGHTDCVRLLLSAEAQ  1016
             T L  A   G  +++S LL   G D       G SA++ A  A  G  + +R LL + A 
Sbjct  529   TPLHLAVITGQTSVVSFLLRV-GADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAP  587

Query  1017  -----VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA-DGGQTPLYLACKNGNK  1070
                  ++  D  G  P+  A      EC++LL+   A +      GG+T L+LA +    
Sbjct  588   AVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEEL  647

Query  1071  ECIK-LLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM  1110
               +  L+ +   N + +T  G TP+H A   G     +LL+
Sbjct  648   GLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLL  688


 Score = 41.6 bits (96),  Expect = 0.003
 Identities = 39/142 (27%), Positives = 63/142 (44%), Gaps = 10/142 (7%)

Query  955   AGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAE  1014
             AG P LL+ A  Q     +  LL+    +       G   ++ A +    +C+ LL+ + 
Sbjct  572   AGAPELLR-ALLQSGAPAVPQLLHMPDFE-------GLYPVHLAVRARSPECLDLLVDSG  623

Query  1015  AQVNAADKNGF-TPLCAAAAQGHFECVELLIS-YDANINHAADGGQTPLYLACKNGNKEC  1072
             A+V A ++ G  T L  A        V  L++   AN+N     G TPL+LA   G    
Sbjct  624   AEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTL  683

Query  1073  IKLLLEAGTNRSVKTTDGWTPV  1094
              +LLL+AG +   +  +   P+
Sbjct  684   TRLLLKAGADIHAENEEPLCPL  705


>gi|11134088|sp|Q92882|OSTF1_HUMAN  Osteoclast-stimulating factor 1
Length=214

 Score = 44.7 bits (104),  Expect = 4e-04
 Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 4/109 (3%)

Query  985   NYSCEDGHSA---LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVE  1041
             NY  E   S    L+ AAK G+   +R  L     VN  DK G T L  A   GH + VE
Sbjct  64    NYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVE  123

Query  1042  LLISY-DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTD  1089
             +L +  +  +N     G T    A   G  + ++LLL  G    ++  +
Sbjct  124   MLFTQPNIELNQQNKLGDTAFDAAAWKGYADIVQLLLAKGARTDLRNIE  172


>gi|30173128|sp|Q9NQS7|INCE_HUMAN  Inner centromere protein
Length=919

 Score = 44.3 bits (103),  Expect = 5e-04
 Identities = 43/173 (24%), Positives = 85/173 (49%), Gaps = 8/173 (4%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
            K  +ER++ + A  ++  KK+E  + + +  E++ ++L    +EE  +  Q +L   KE 
Sbjct  608  KAKEERLAEEKAKKKAAAKKMEEVEARRKQ-EEDARRLRWLQQEEEERRHQELLQKKKEE  666

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEA-QMEKQLSEFDTE  484
            +Q   +   EA++L +   +   E+++  +   E    ++   E E  + E+QL+E +  
Sbjct  667  EQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERREQERQLAEQERR  726

Query  485  REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
            REQ R +  RE      L+E    +R   EQL+R  + K      ++  +R+L
Sbjct  727  REQERLQAERE------LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL  773


>gi|85682779|sp|Q9ULT8|HECD1_HUMAN  E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 
1) (E3 ligase for inhibin receptor) (EULIR)
Length=2612

 Score = 44.3 bits (103),  Expect = 5e-04
 Identities = 37/127 (29%), Positives = 57/127 (44%), Gaps = 3/127 (2%)

Query  984   INYSCEDGHSALYSAAKNGHTDCVRLLLSAEA-QVNAADKNGFTPLCAAAAQGHFECVEL  1042
             ++ S E  H  L    ++  TD +   +   A +VN  D  G T L  A+A G  E VE 
Sbjct  355   LDSSGERSHRQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEF  414

Query  1043  LISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGN  1102
             L    A++N         L+ A   G  +  K LL  G N  ++  DG TP+  A + G+
Sbjct  415   LCERGADVNRGQRSSS--LHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGH  472

Query  1103  VDSLKLL  1109
              + + +L
Sbjct  473   SEVVAIL  479


 Score = 40.4 bits (93),  Expect = 0.008
 Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 3/87 (3%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             TLL  A+A G   ++  L  E G D+N       S+L+ AA  G     + LL   A  +
Sbjct  398   TLLNWASAFGTQEMVEFLC-ERGADVNRGQRS--SSLHYAACFGRPQVAKTLLRHGANPD  454

Query  1019  AADKNGFTPLCAAAAQGHFECVELLIS  1045
               D++G TPL  A  +GH E V +L S
Sbjct  455   LRDEDGKTPLDKARERGHSEVVAILQS  481


>gi|27923747|sp|Q96P50|CENB5_HUMAN  Centaurin-beta 5 (Cnt-b5)
Length=759

 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 2/121 (1%)

Query  996   YSAAKNGHTDCVRLLLSAEAQVNAADKN--GFTPLCAAAAQGHFECVELLISYDANINHA  1053
             + AA+      +   L+  A+VN AD    G TPL  A   G     E L+   A++N  
Sbjct  598   HRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQR  657

Query  1054  ADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
                G+ PL+ A   G    + L L+ G ++     +   P+  AV   N D + LL   R
Sbjct  658   DSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLAR  717

Query  1114  I  1114
             +
Sbjct  718   M  718


 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query  959   TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVN  1018
             T L QA   G++ +   LL + G D+N     G + L+ A   G T  V L L   A  +
Sbjct  630   TPLVQAVLGGSLIVCEFLL-QNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQH  688

Query  1019  AADKNGFTPLCAAAAQGHFECVELL  1043
             A D+    PL  A    + + V LL
Sbjct  689   ALDQEQRDPLAIAVQAANADIVTLL  713


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 26/112 (23%), Positives = 45/112 (40%), Gaps = 16/112 (14%)

Query  1044  ISYDANIN--HAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTG  1101
             +++ A +N   A D G+TPL  A   G+    + LL+ G + + + + G  P+H A   G
Sbjct  613   LAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLG  672

Query  1102  NVDSLKLLMYHRIPAHGnsfneeesessVFDLDGGEESPEGISKPVVPADLI  1153
                 + L +      H               LD  +  P  I+     AD++
Sbjct  673   RTGQVCLFLKRGADQHA--------------LDQEQRDPLAIAVQAANADIV  710


>gi|417216|sp|P33176|KINH_HUMAN  Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC)
Length=963

 Score = 43.9 bits (102),  Expect = 7e-04
 Identities = 49/219 (22%), Positives = 88/219 (40%), Gaps = 35/219 (15%)

Query  379  AESRQKKLEMEKLQLQALEQEHKKLAARLEEER-GKNKQVVLMLVKECKQLSGKVIEEAQ  437
            AE  +KK E EK + + L    + L   L   R G+   +     KE   L    +++  
Sbjct  337  AEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDK--  394

Query  438  KLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE-------------  484
               D+    ++       +     AE+R+  E  A++ KQL + D E             
Sbjct  395  ---DITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKT  451

Query  485  ---------------REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLP  529
                           ++ ++A+LNR +A     KEE+ ++ + +E+L    D K S  + 
Sbjct  452  QMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQK-SQEVE  510

Query  530  RKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKK  568
             KTK+  L+S  +  +     S+  +   + E  +H KK
Sbjct  511  DKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKK  549


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 36/162 (22%), Positives = 74/162 (45%), Gaps = 18/162 (11%)

Query  413  KNKQVVLMLVKECKQLSGKVIEEAQKLED---VMAkleeekkktneleeelSAEKRRSTE  469
            K K  V  +VK CKQL     E  +K+E+    +A  +    +     + L+   +   +
Sbjct  596  KMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQ  655

Query  470  MEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLP  529
             + Q+E+ +     E  QLRA   +E+ H  + KE ++K+ +   ++K+  + +  +   
Sbjct  656  KKRQLEESVDALSEELVQLRA---QEKVHEME-KEHLNKV-QTANEVKQAVEQQ--IQSH  708

Query  530  RKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPL  571
            R+T  +++ S+           V  +  L+T+  D  +K+ L
Sbjct  709  RETHQKQISSL--------RDEVEAKAKLITDLQDQNQKMML  742


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 37/191 (19%), Positives = 84/191 (43%), Gaps = 23/191 (12%)

Query  356  SILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNK  415
            S ++ ++  CK+++   +      E  +K+L   +L++   E + K L   L+    K +
Sbjct  599  SEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKR  658

Query  416  QV---VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEA  472
            Q+   V  L +E  QL  +  E+  ++E                      + + + E++ 
Sbjct  659  QLEESVDALSEELVQLRAQ--EKVHEMEKEHLN-----------------KVQTANEVKQ  699

Query  473  QMEKQL-SEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRK  531
             +E+Q+ S  +T ++Q+ +  +  EA    + +  D+ +KM+ + +R       L    +
Sbjct  700  AVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQ  759

Query  532  TKDRRLVSISV  542
             K R+L  ++V
Sbjct  760  EKSRKLHELTV  770


>gi|28201804|sp|Q14789|GOGB1_HUMAN  Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa 
Golgi complex-associated protein) (GCP372)
Length=3259

 Score = 43.5 bits (101),  Expect = 9e-04
 Identities = 53/218 (24%), Positives = 91/218 (41%), Gaps = 48/218 (22%)

Query  303   IKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVM  362
             +KT K EN       IQ++    +      +LQ D +   GD ++       LSI+    
Sbjct  2445  LKTIKKEN-------IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE--ERHLSII----  2491

Query  363   AHCKKMQERMSAQLAAAESRQKKLEMEKLQ--LQALEQEHKKLAARLEEERGKNKQVVLM  420
                  +++    Q AAAE+ + K E+  L+  +  L  E+ KL A L + R    QV+ +
Sbjct  2492  -----LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI  2546

Query  421   LVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSE  480
                + KQL    +++ ++LE+                              A++E++L E
Sbjct  2547  KDSQQKQLLEVQLQQNKELEN----------------------------KYAKLEEKLKE  2578

Query  481   FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
              +   E LR   N  +    DL +EI+ ++  I QL R
Sbjct  2579  SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR  2616


 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 54/297 (18%), Positives = 116/297 (39%), Gaps = 63/297 (21%)

Query  271   SELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDP  330
             S    L   +EG  E ++ +++ +  LK     ++ +W+   ++                
Sbjct  1567  SSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE----------------  1610

Query  331   FLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEK  390
                LQ++YE      E     +N    ++ V+   ++ ++ +  +L + E+ +K+ E   
Sbjct  1611  ---LQKEYEILLQSYEN---VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK--  1662

Query  391   LQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeek  450
              QLQ  EQE +++  ++ +     +Q +L L +E  +L  +V       ++ M       
Sbjct  1663  -QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECM-------  1714

Query  451   kktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMR  510
                                  A M+++L     E E L  K     +    L EE+  ++
Sbjct  1715  --------------ETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLK  1760

Query  511   KMIE---------QLKRGSDSKPSL------SLPRKTKDRRLVSISVGTEGTVTRSV  552
               IE         +     D++ ++      S+P +T+++   S+S+ T  T + SV
Sbjct  1761  HQIEDNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQD--SLSMSTRPTCSESV  1815


 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 45/174 (25%), Positives = 85/174 (48%), Gaps = 23/174 (13%)

Query  379   AESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQK  438
             AES Q+KLE  +LQ+  LE   ++L  +L+E     ++++    ++   LSG++ E+   
Sbjct  1367  AESLQQKLESSQLQIAGLE-HLRELQPKLDE----LQKLISKKEEDVSYLSGQLSEKEAA  1421

Query  439   LEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQL----RAK---  491
             L  +  ++ E++     L  +L  + +   E   Q++ +L E   + E++    RAK   
Sbjct  1422  LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQI  1481

Query  492   --------LNREEA--HTTDLKEEIDKMRKMIEQLKRG-SDSKPSLSLPRKTKD  534
                     ++R+EA      L+EE+   R  IE+L +  +D +  +S   K KD
Sbjct  1482  QRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKD  1535


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 42/204 (20%), Positives = 90/204 (44%), Gaps = 18/204 (8%)

Query  347   KKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAAR  406
             K  +  + +  L+  ++  ++ ++++  +    ES  +K  +EK+Q    E  +K  A  
Sbjct  1950  KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE  2009

Query  407   LEEERGKNKQVVLMLVKECKQLSGKV--IEEAQKLEDVMAkleeekkktneleeelSAEK  464
             L+E   + +Q V  L K+C +   K+  +E   K  + +    ++  +  +     + E 
Sbjct  2010  LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH  2069

Query  465   RRSTEMEAQMEKQLSEFDTEREQLRA-----KLNRE-----EAHTTDLKEEIDKMRKMIE  514
             R+  + E    K L + DT+ E  R      KL +E     E+  + +K++ + + + +E
Sbjct  2070  RKKAQAELASFKVLLD-DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE  2128

Query  515   Q-----LKRGSDSKPSLSLPRKTK  533
             Q     LK   + +  L   R+ K
Sbjct  2129  QAEEKHLKEKKNMQEKLDALRREK  2152


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 54/250 (21%), Positives = 97/250 (38%), Gaps = 36/250 (14%)

Query  307   KWENARRKEVFIQERYGRFN--LNDPFLALQRDYEAGAGDKEKKPVCTNPLSILE----A  360
             K +  RR++V ++E  G     LN     +Q+  E       +    T  +S L+     
Sbjct  2144  KLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDR  2203

Query  361   VMAHCKKMQERMSAQLAAAES----------------RQKKLEMEKLQLQALEQEHKK--  402
             V+   KK + + S  + + E                 RQ  + ME+L++     EH K  
Sbjct  2204  VIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQI  2263

Query  403   ------LAARLEEE-----RGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekk  451
                      +L+++     +G+NK+++  L +E + L      E  KLE  +  L+++  
Sbjct  2264  WESKAQTEVQLQQKVCDTLQGENKELLSQL-EETRHLYHSSQNELAKLESELKSLKDQLT  2322

Query  452   ktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRK  511
               +   E+   +K     +  Q E  +       EQL   L      T+ L EEI+   +
Sbjct  2323  DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQ  2382

Query  512   MIEQLKRGSD  521
              I  L  G +
Sbjct  2383  KIISLLSGKE  2392


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 36/193 (18%), Positives = 82/193 (42%), Gaps = 10/193 (5%)

Query  363   AHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLV  422
             +H K++QE +  +    +  QK     + ++ ALE+  K L   ++ E  K+ ++     
Sbjct  2005  SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF-VQTESQKDLEIT----  2059

Query  423   KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRR-STEMEAQMEKQLSEF  481
                K+   + +E  +K +  +A  +     T      + A+  +   E+++  E   S+ 
Sbjct  2060  ---KENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM  2116

Query  482   DTEREQLRAKLNR-EEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSI  540
               + E L  +L + EE H  + K   +K+  +  +     ++   + +    KD+ +  +
Sbjct  2117  KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL  2176

Query  541   SVGTEGTVTRSVA  553
                 + TVT+  A
Sbjct  2177  QENLDSTVTQLAA  2189


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 33/141 (23%), Positives = 60/141 (42%), Gaps = 11/141 (7%)

Query  283  ELEARDLVIEALRELKWFTGIKTAKWENARRKEV---FIQERYGRFNLN-----DPFLAL  334
            E+E   ++ + L+E + F     A+    + ++     ++E+  RF        D  L L
Sbjct  181  EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL  240

Query  335  QRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQ  394
                +     ++K  V    L   E  +    ++ + +  +L AAE R + L     QLQ
Sbjct  241  VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ---QLQ  297

Query  395  ALEQEHKKLAARLEEERGKNK  415
             +E EH  L   +E ER ++K
Sbjct  298  QMEAEHNTLRNTVETEREESK  318


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 21/101 (20%), Positives = 49/101 (48%), Gaps = 1/101 (0%)

Query  461   SAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGS  520
             ++E  + +E   Q+++Q+++   E E L+   +  E H   L+++++  +  I  L+   
Sbjct  1329  TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR  1388

Query  521   DSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTE  561
             + +P L   +K   ++   +S    G ++   A  T + TE
Sbjct  1389  ELQPKLDELQKLISKKEEDVSY-LSGQLSEKEAALTKIQTE  1428


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 46/182 (25%), Positives = 71/182 (39%), Gaps = 35/182 (19%)

Query  345   KEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLA  404
             +EK       +  LE V    +K  E     LA A   +KK + E    + L  + +  A
Sbjct  2032  QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA  2091

Query  405   ARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEK  464
             AR+  +  K K+ +    +  K       +  QK ED+                    E+
Sbjct  2092  ARVLADNLKLKKELQSNKESVKS------QMKQKDEDL--------------------ER  2125

Query  465   RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI----DKMRKMIEQLKRGS  520
             R    +E   EK L E    +E+L A L RE+ H  +   EI    +K  K ++QL+   
Sbjct  2126  R----LEQAEEKHLKEKKNMQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENL  2180

Query  521   DS  522
             DS
Sbjct  2181  DS  2182


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 47/230 (20%), Positives = 100/230 (43%), Gaps = 33/230 (14%)

Query  398   QEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnele  457
             Q  KK  + L+ +R +       L+KE K L  + ++  Q++ ++     + ++      
Sbjct  2877  QSLKKAMSSLQNDRDR-------LLKELKNLQQQYLQINQEITELHPLKAQLQEYQ----  2925

Query  458   eelSAEKRRSTE-MEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI-------DKM  509
                  +K ++ + M+ ++ ++   +  E  QLR + +  E H   +KE+        D+ 
Sbjct  2926  -----DKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQ  2980

Query  510   RKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLV-TENADHMKK  568
                ++ L R   S  S + P K + +R  S         ++++  +T+L+ T+  D +K+
Sbjct  2981  LSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKE  3040

Query  569   L---PLTMPVKPSTGSPLVSANAKGSV--CTSATMARPGIDRQASYGDLI  613
             +    L +    S  S L+      S+  C ++   R   + Q  YGDL+
Sbjct  3041  IHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLR---ENQQHYGDLL  3087


>gi|32469733|sp|Q8IWJ2|GCC2_HUMAN  GRIP and coiled-coil domain-containing protein 2 (Golgi coiled 
coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated 
antigen KW-11)
Length=1583

 Score = 43.5 bits (101),  Expect = 9e-04
 Identities = 70/356 (19%), Positives = 140/356 (39%), Gaps = 46/356 (12%)

Query  204   DKISKPPLRRLNVVPLTTFKQIKEIGKEPAPAVREASPSWRSVVRWPTPSMIIISRKKEF  263
             D ++K P  + +  PL++ K+++E  +      +E       +       ++ +  KKE 
Sbjct  829   DSLAKSPSVKND--PLSSVKELEEKIENLEKECKEKEEKINKI------KLVAVKAKKEL  880

Query  264   DVDTLSKSELRMLLSVMEGELEARDLVIEALREL-KWFTGIKTAKWENARRKEVFIQERY  322
             D    S+ E + +   +E     +D +  ++R+L +     K    E  ++ E    E+ 
Sbjct  881   DS---SRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE  937

Query  323   GRFNLNDPFLALQRDYEAGAGDKEK-KPVCTNPLSILEAVMAHCKKMQERMSAQLAAAES  381
                N       L R         E       + L+ +E + ++ K ++ ++     A   
Sbjct  938   RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM  997

Query  382   RQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLED  441
               K+LE EKLQ +   +EH      LEE       + + L KE KQL     +  Q+LE 
Sbjct  998   VDKELEAEKLQKEQKIKEHATTVNELEE-------LQVQLQKEKKQLQ----KTMQELEL  1046

Query  442   VMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
             V                      ++  +    M  ++++++   ++L  KL  +     D
Sbjct  1047  V----------------------KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIED  1084

Query  502   LKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTD  557
             L++EI   ++  E L+    S  S     + K+ ++  + V T+  +  S   +TD
Sbjct  1085  LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD  1140


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 63/304 (20%), Positives = 123/304 (40%), Gaps = 23/304 (7%)

Query  255   IIISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALR-ELKWFTGIKTAKWENARR  313
             +++  KKE      ++++  +L + ++GELEA    +E  + +L   T  K    E+ + 
Sbjct  1123  LLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT  1182

Query  314   KEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMS  373
                  Q     +       ALQ +  A    K ++   T+     +  + +  K Q+  S
Sbjct  1183  SAEQHQRTLSAYQQR--VTALQEECRAA---KAEQATVTSEFESYKVRVHNVLKQQKNKS  1237

Query  374   ---AQLAAAESRQKKLEMEKLQLQA-LEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS  429
                A+   A+  ++ LEM   QL+  L+     L   + E +    +   +L +  K L 
Sbjct  1238  MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQ  1297

Query  430   GKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLR  489
               V +EA+  E + +   E            S   +  +++ +Q E   + F   R+Q+R
Sbjct  1298  ETVSKEAELREKLCSIQSENMMMK-------SEHTQTVSQLTSQNEVLRNSF---RDQVR  1347

Query  490   AKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTK---DRRLVSISVGTEG  546
                         L++++ KM   + QLK    ++  +S  +  K   +RR   + +    
Sbjct  1348  HLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMH  1407

Query  547   TVTR  550
             TVTR
Sbjct  1408  TVTR  1411


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 27/140 (19%), Positives = 69/140 (49%), Gaps = 4/140 (2%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             K++ ++++ +    E  +++++++K + + L++E   L + +++   KN ++  +LVK  
Sbjct  1069  KELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTK  1128

Query  426   KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
             K+L+    +  Q   D +      K +    ++++   K +  E+ ++  K      T  
Sbjct  1129  KELA----DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSA  1184

Query  486   EQLRAKLNREEAHTTDLKEE  505
             EQ +  L+  +   T L+EE
Sbjct  1185  EQHQRTLSAYQQRVTALQEE  1204


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 39/195 (20%), Positives = 83/195 (42%), Gaps = 36/195 (18%)

Query  357  ILEAVMAHCKKMQERMSAQLAAAESRQ--KKLEMEKLQLQALEQEHKKLAARLEEERGKN  414
            +LE   A+ K   E  +  +   E  Q   K E+   + +   +EH+ L   LE++  ++
Sbjct  760  LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD  819

Query  415  KQVVLMLVKECKQLSGKV----IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM  470
            ++  L+L+K+    S  V    +   ++LE                      EK  + E 
Sbjct  820  RRAELILLKDSLAKSPSVKNDPLSSVKELE----------------------EKIENLEK  857

Query  471  EA-QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK-------RGSDS  522
            E  + E+++++      + + +L+     T  +KEE++ +R   +QL        +G++S
Sbjct  858  ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES  917

Query  523  KPSLSLPRKTKDRRL  537
              +L L  + +  +L
Sbjct  918  YKNLLLEYEKQSEQL  932


>gi|27923745|sp|Q96P47|CENG3_HUMAN  Centaurin-gamma 3
Length=876

 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 3/89 (3%)

Query  961   LQQAAAQGNVTLLSMLL---NEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQV  1017
             L +A  + ++ LL MLL   ++E ++  Y   DG +AL+ ++   +    +LL+     V
Sbjct  754   LLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDV  813

Query  1018  NAADKNGFTPLCAAAAQGHFECVELLISY  1046
              + D  G TPL  A   G  EC ++LI +
Sbjct  814   RSRDARGLTPLAYARRAGSQECADILIQH  842


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 0/67 (0%)

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
             E      D +G T L  ++A  +    +LLI Y  ++      G TPL  A + G++EC 
Sbjct  777   EVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECA  836

Query  1074  KLLLEAG  1080
              +L++ G
Sbjct  837   DILIQHG  843


>gi|1345731|sp|P49454|CENPF_HUMAN  CENP-F kinetochore protein (Centromere protein F) (Mitosin) (AH 
antigen)
Length=3210

 Score = 43.1 bits (100),  Expect = 0.001
 Identities = 36/158 (22%), Positives = 69/158 (43%), Gaps = 24/158 (15%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
            KK+ E +S Q   AES +           +LEQ+ K+     +EE  + ++    L +EC
Sbjct  365  KKLTEDLSCQRQNAESARC----------SLEQKIKEKEKEFQEELSRQQRSFQTLDQEC  414

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
             Q+  ++ +E Q+ +++                 L AE  + T ++ Q+E  L EF  + 
Sbjct  415  IQMKARLTQELQQAKNM--------------HNVLQAELDKLTSVKQQLENNLEEFKQKL  460

Query  486  EQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
             +        +    +L+  +++M+K    LK  S+ K
Sbjct  461  CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQK  498


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 53/218 (24%), Positives = 107/218 (49%), Gaps = 11/218 (5%)

Query  355  LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQ--ALEQEHKKLA-ARLEEER  411
            L  ++  +   +   E M A+  + E+  + L+ EK+  Q  +L  E  KLA A LE++R
Sbjct  509  LKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ-EKINQQENSLTLEKLKLAVADLEKQR  567

Query  412  GKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME  471
              ++ ++       +QL+ K+ +  ++ + +++ LE +KK+  EL      EK   +  +
Sbjct  568  DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL----KEEKTLFSCWK  623

Query  472  AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRK  531
            ++ EK L++ ++E+E L++K+N  E   T LK +  K  +  E+++     + +LS+  +
Sbjct  624  SENEKLLTQMESEKENLQSKINHLE---TCLKTQQIKSHEYNERVRTLEMDRENLSVEIR  680

Query  532  TKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKL  569
                 L S SV  E      +  Q      +  H K++
Sbjct  681  NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEI  718


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 49/217 (22%), Positives = 97/217 (44%), Gaps = 17/217 (7%)

Query  332   LALQRDYEAGAGDKEKKPVCTNP-LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEK  390
             L L++D E    +K+K  VC    LS++ +     +   + MS +  A +   +K++ + 
Sbjct  2029  LCLEKDNE----NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT  2084

Query  391   LQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQL---SGKVIEEAQKLEDVMAkle  447
              +L++ + E        E E  +  +++  L  +  +L      + E+ Q LE     L 
Sbjct  2085  QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS  2144

Query  448   eekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER----EQLRAKLNRE---EAHTT  500
               K +      +L+ EK    +    ++ +LSE D E+    + L A L  +       +
Sbjct  2145  LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS  2204

Query  501   DLKEEIDKMRKMIEQL--KRGSDSKPSLSLPRKTKDR  535
               +EE+ ++R+ IE+L  +  +D K  L +  K K+R
Sbjct  2205  STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKER  2241


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 72/326 (22%), Positives = 142/326 (43%), Gaps = 41/326 (12%)

Query  269   SKSELRMLLSVMEG---ELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRF  325
             SK E+  L + +EG    L   +L +  +R  K           N  +KE   QER    
Sbjct  2458  SKGEVETLKAKIEGMTQSLRGLELDVVTIRSEK-------EDLTNELQKE---QERISEL  2507

Query  326   NL-NDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQK  384
              + N  F  + ++ E     +EK  +     + +E +    K++ ER++A     E+ + 
Sbjct  2508  EIINSSFENILQEKE-----QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA  2562

Query  385   KLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLML--------VKECKQLSGKVIEEA  436
             K +    Q++ LE E  +L   L+E   KN  +VL          V++ KQ   K  EE 
Sbjct  2563  KEQNLSSQVECLELEKAQLLQGLDE--AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI  2620

Query  437   QKLEDVMAkleeekkktneleeelSAEKRRSTEME---AQMEKQLSEFDTEREQLRAKLN  493
              +L++ +   E+   K +++E E    K ++ E+     ++E+++    ++   L+  L 
Sbjct  2621  SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLE  2680

Query  494   REEAHTTDLKEEID--KMRKM--IEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVT  549
               ++   +L+ E++  KM KM  +E++ + +  +  L        ++   +     G   
Sbjct  2681  VLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKN  2740

Query  550   RSVACQTDLVTE----NADHMKKLPL  571
             R +A +  L+ E    + D +K+L L
Sbjct  2741  R-LAGELQLLLEEIKSSKDQLKELTL  2765


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 42/189 (22%), Positives = 83/189 (43%), Gaps = 16/189 (8%)

Query  353   NPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG  412
             N    LEA +    +   R+S+        ++ +E  +++++A E++   +A +L+E   
Sbjct  2184  NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER  2243

Query  413   KN---KQVVLMLVKECKQLSGKVIE-----------EAQKLEDVMAkleeekkktnelee  458
             +N   K  V  L +E  Q+S +  E           E + L+  + ++    K       
Sbjct  2244  ENDSLKDKVENLEREL-QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV  2302

Query  459   elSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE-QLK  517
              L +EK   T+   + + QLSE D      ++ L  +E     +KEE     +M++ QLK
Sbjct  2303  TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK  2362

Query  518   RGSDSKPSL  526
               +++  +L
Sbjct  2363  ELNEAVAAL  2371


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 106/503 (21%), Positives = 183/503 (36%), Gaps = 83/503 (16%)

Query  78    QPTDLEYKKLLWYRMNAEAPTASSIFQAEKRHKRDGAYIREAKLT-----QHSRNPFTQN  132
             Q  DLE+K  L      +         AE    RD    ++A L      Q S   F Q 
Sbjct  731   QVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ  790

Query  133   PLPHW-------QKRGLPEEMAEYTL---------------LDVLH--LEFHSPQGPDLS  168
             P  H        ++  +P E +E  L               +D L   LE       DL 
Sbjct  791   PAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQ  850

Query  169   KRT--LVQAESTICPHFLACKTLCFTYIGWFLMTQVIDKISKPPLRRLNVVPLTTFKQIK  226
             K+   LVQ +  I  + +  + +  +++     +Q I K+ +      NVV   T   ++
Sbjct  851   KQCEELVQIKGEIEENLMKAEQMHQSFVAE--TSQRISKLQEDTSAHQNVVA-ETLSALE  907

Query  227   EIGKEPAPAVREASPSWRSVVRWPTPSMIIISRKKEFDV--DTLS--KSELRMLLSVMEG  282
                KE      +       +      + ++    KE  +  +TLS  K E+  ++S+ + 
Sbjct  908   NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKR  967

Query  283   ELEARDLVIEALRELKWFTGIKTAKWENARRKEVF---IQERYGRFN-LNDPF-----LA  333
             E+E        L+E+     +   K    ++ E F   I ER    + L+D +     + 
Sbjct  968   EIEELTQENGTLKEIN--ASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL  1025

Query  334   LQRDYEAGAGDKE---KKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEK  390
             LQR  E G   ++   K        S LE ++  C  + E             +K E+E+
Sbjct  1026  LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCEN------------RKNELEQ  1073

Query  391   LQLQALEQEHKKLAARLE--EERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAklee  448
             L+ +A  +EH++   +L   EER +N  + L  V++  +      +   K E        
Sbjct  1074  LK-EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE--------  1124

Query  449   ekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDK  508
                        L  E     E + +M+K++++   E EQL   +  +        E I  
Sbjct  1125  --------AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRN  1176

Query  509   MRKMIEQLKRGSDSKPSLSLPRK  531
               K  E  +   + KP + L  K
Sbjct  1177  SVKERESERNQCNFKPQMDLEVK  1199


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 25/89 (28%), Positives = 46/89 (51%), Gaps = 10/89 (11%)

Query  358   LEAVMAHCKKMQERMS------AQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEER  411
             ++ ++  CK+++E         +QL AA+ +QK   +   ++  L  E K+L   LEE  
Sbjct  2891  MKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE--  2948

Query  412   GKNKQVVLMLVKECKQL-SGKVIEEAQKL  439
              K K+    L K C  L S + +E+A+++
Sbjct  2949  -KTKEADEYLDKYCSLLISHEKLEKAKEM  2976


>gi|14195007|sp|Q15149|PLEC1_HUMAN  Plectin 1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1)
Length=4684

 Score = 42.7 bits (99),  Expect = 0.002
 Identities = 51/220 (23%), Positives = 100/220 (45%), Gaps = 21/220 (9%)

Query  367   KMQERMSAQLAAAESRQKKLE-MEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             ++  R+ A+  AA  +Q+ L+ +E+L+LQA E E  +   + E ER +  QV L   +  
Sbjct  1653  ELASRVKAEAEAAREKQRALQALEELRLQAEEAE--RWLCQAEVERARQVQVALETAQRS  1710

Query  426   KQ--LSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDT  483
              +  L  K    A+K   +  +   +++     +    AE+R   + EA+  ++ +E   
Sbjct  1711  AEAELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERQL  1768

Query  484   ER------EQLRAKLNREEA--HTTDLKEEIDKMRKMIE-QLKRGSDSKPSLSLPRKTKD  534
             ER      E LR +L  EE     +  + E +K ++  E + +R   ++      R+  +
Sbjct  1769  ERWQLKANEALRLRLQAEEVLQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE  1828

Query  535   RRLVSISVGTEGTVTRSVACQTDLV-----TENADHMKKL  569
             + L       EGT  + +A + +L+     TE  +  ++L
Sbjct  1829  QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL  1868


 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 51/252 (20%), Positives = 110/252 (43%), Gaps = 35/252 (13%)

Query  283   ELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDP---FLALQRDYE  339
             E+E     +E  R L+     + A+ E+AR+ ++  +    R    +    F   Q++ E
Sbjct  2147  EVERLKAKVEEARSLR-----ERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE  2201

Query  340   AGAGDKEKKPVCTNPLSILEAVMAHCKKMQE-RMSAQLAAAESRQKKLEMEKLQLQALEQ  398
                  ++++ V        EA     ++ +E R+ A+  AA+SR++  E E+L+  A EQ
Sbjct  2202  LQQTLQQEQSVLDRLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ  2261

Query  399   EH---------KKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleee  449
                        +KL    E+E  +  Q     +++ KQ +   +E+ +K  +        
Sbjct  2262  AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ-KQAADAEMEKHKKFAE--------  2312

Query  450   kkktneleeelSAEKRRSTEMEAQMEK---QLSEFDTEREQLRAKLNREEAHTTDLKEEI  506
                  +   + +  ++  T +  Q+E+   Q +  D E ++L+A+        + ++EE+
Sbjct  2313  -----QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL  2367

Query  507   DKMRKMIEQLKR  518
               +R  +E+L +
Sbjct  2368  FSVRVQMEELSK  2379


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 38/163 (23%), Positives = 78/163 (47%), Gaps = 12/163 (7%)

Query  359   EAVMAHCKKMQERMS-AQLAAAESRQKKLEMEKLQLQA-LEQEHKKLAARLEEERGKNKQ  416
             E  +A  ++ +ER   A++ AA  +Q++L     Q +A  E+E K+L  R++EE  + ++
Sbjct  1484  EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRIQEEVVRREE  1543

Query  417   VVLMLVKECKQLSGKVIEEAQKLE-----DVMAkleeekkktneleeelSAEKRRSTEME  471
               +    + +Q    + EE Q+L      ++ AK  + +             +    ++E
Sbjct  1544  AAV----DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE  1599

Query  472   AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
             A  E+Q    + E + LRA+    EA     +EE +++R+ ++
Sbjct  1600  AT-ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ  1641


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 45/275 (16%), Positives = 112/275 (40%), Gaps = 27/275 (9%)

Query  270   KSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWEN------ARRKEVFIQERYG  323
             ++E R  L+ +E  LE +  + EA  + K     +  + +        RR+E  +  +  
Sbjct  1492  RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRIQEEVVRREEAAVDAQQQ  1551

Query  324   RFNLNDPFLALQRDYEAGAGDKEKKPVCTN--------PLSILEAVMAHCKKMQERMSAQ  375
             + ++ +    L++  EA    K ++              + ++   +   ++ +     +
Sbjct  1552  KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE  1611

Query  376   LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEE  435
             L A  +R ++ E +K Q Q   +E ++L  ++++E  + +Q  + L    K    +   E
Sbjct  1612  LQALRARAEEAEAQKRQAQ---EEAERLRRQVQDESQRKRQAEVELASRVKA-EAEAARE  1667

Query  436   AQKLEDVMAkleeekkktneleeelSAEKRRSTEM---------EAQMEKQLSEFDTERE  486
              Q+    + +L  + ++      +   E+ R  ++         EA+++ + + F  +  
Sbjct  1668  KQRALQALEELRLQAEEAERWLCQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA  1727

Query  487   QLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD  521
             QL   L  E      L+EE ++  +   + +R  +
Sbjct  1728  QLERSLQEEHVAVAQLREEAERRAQQQAEAERARE  1762


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 55/240 (22%), Positives = 103/240 (42%), Gaps = 44/240 (18%)

Query  304   KTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMA  363
             K +  E  R+K +       R  + +  LAL+  +E  A  K +          LE  + 
Sbjct  2037  KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE----------LELELG  2086

Query  364   HCKKMQE---RMSAQLAAAESRQKKL--EMEKLQLQALEQEHKKLAARLEEERGKNKQVV  418
               +   E   R   Q     +RQ++L  E E+ + +A E+  K LAA  EEE  + ++  
Sbjct  2087  RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA--EEEAARQRKAA  2144

Query  419   LMLVKECKQLSGKVIEEAQKLED----------VMAkleeekkktneleeelSAEKRRST  468
             L   +E ++L  KV EEA+ L +           +A+   +K+   E +    A +++  
Sbjct  2145  L---EEVERLKAKV-EEARSLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ  2200

Query  469   EMEAQMEKQLSEFD-------------TEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQ  515
             E++  ++++ S  D              E E+ R +  RE A +    EE +++++  E+
Sbjct  2201  ELQQTLQQEQSVLDRLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE  2260


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 66/317 (20%), Positives = 130/317 (41%), Gaps = 49/317 (15%)

Query  230   KEPAPAVREASPSWRSVVRWPTPSMIIISRKKEFDVDTLSKSELRMLLSVMEGELEARDL  289
             ++ A A R    + R + RW   +   +  + + +     KS     L+  E E +  + 
Sbjct  1752  QQQAEAERAREEAERQLERWQLKANEALRLRLQAEEVLQQKS-----LAQAEAEKQKEEA  1806

Query  290   VIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKP  349
               EA R  K       A+ +  R++E+  QE             L++  +   G  +++ 
Sbjct  1807  EREARRRGK-------AEEQAVRQRELAEQE-------------LEKQRQLAEGTAQQRL  1846

Query  350   VCTNPLSILEAVMAHCKKMQE-------RMSAQLAAAESRQKKLEMEKLQLQALEQEHKK  402
                  L  L A     ++ ++       R+  + AAA  ++++LE E  +++A  +    
Sbjct  1847  AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA  1906

Query  403   LAARLEEE-RGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelS  461
               A+ EEE R  +++    L  E  +   ++ EEA +L  +  + + +++   E      
Sbjct  1907  SKAKAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQR  1965

Query  462   AEKRR-----------STEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMR  510
             AE  R           +T ++ + E  L E + E E+LR     E      L+E+  + +
Sbjct  1966  AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK  2025

Query  511   KMIE----QLKRGSDSK  523
               IE    QL++ SDS+
Sbjct  2026  ADIEERLAQLRKASDSE  2042


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 29/172 (16%), Positives = 81/172 (47%), Gaps = 19/172 (11%)

Query  366   KKMQERMSAQLAAAE--SRQKKLEMEKLQLQALEQEH-----KKLAARLEEERGKNKQVV  418
             +K  E +  +L   E  +++K   ++ L++Q  + +H     ++  A LE E+ K +Q  
Sbjct  2544  RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA  2603

Query  419   LMLVKECKQLSG----KVIEEAQKLEDVMAkleeekkktneleeelSA--------EKRR  466
              +L  + +++      ++++E Q L+      ++   +     E+  A        E  +
Sbjct  2604  KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK  2663

Query  467   STEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
             + ++  + ++Q  + + ER++L A +        + +E + + ++ ++QL++
Sbjct  2664  AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ  2715


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 29/137 (21%), Positives = 62/137 (45%), Gaps = 14/137 (10%)

Query  382   RQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLED  441
             + K++  E  +L    QE  +L    EE+  + + +   ++KE  Q     ++EA +L+ 
Sbjct  2409  KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ----AVQEATRLK-  2463

Query  442   VMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
                    E +   + +E    + RR  E + QM +QL+E   E +  +  L  E     +
Sbjct  2464  ------AEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---ETQGFQRTLEAERQRQLE  2514

Query  502   LKEEIDKMRKMIEQLKR  518
             +  E ++++  + ++ R
Sbjct  2515  MSAEAERLKLRVAEMSR  2531


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 38/161 (23%), Positives = 77/161 (47%), Gaps = 15/161 (9%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
             LEA  A  KK++ +  AQ    ++ + +L   +   + L+Q H +    +E  R +    
Sbjct  1262  LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER----  1317

Query  418   VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
             V  L++  + +  +     ++LE +  +L   ++  + L   L   +RR  +++A     
Sbjct  1318  VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM---P  1374

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
             L++    REQLR    +E+A    L EEI++  + +E+ +R
Sbjct  1375  LADSQAVREQLR----QEQA----LLEEIERHGEKVEECQR  1407


>gi|14194715|sp|Q92817|EVPL_HUMAN  Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) 
(210 kDa cornified envelope precursor protein)
Length=2033

 Score = 42.7 bits (99),  Expect = 0.002
 Identities = 51/196 (26%), Positives = 88/196 (44%), Gaps = 32/196 (16%)

Query  369   QERMSAQLAAAESRQKKLEMEKLQLQA---------------LEQEHKKLAARLEEERGK  413
             Q+R +A+ A  E + K+L +E+ + +                L +EH +L+  L+EE G+
Sbjct  1342  QKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGR  1401

Query  414   NKQVVLMLVKECKQLSGKVIEEAQKL---EDVMAkleeekkktneleeelSAEKRRSTEM  470
              +Q+ L    E +QL   V E+   L   ED   KL  E++           EKR  T  
Sbjct  1402  RRQLEL----EVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQ  1457

Query  471   E-------AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
             E        ++EK   + +   E LR  L++E+   T+L  E   ++  I+ L++    +
Sbjct  1458  EKIIMEEVVKLEKD-PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQE  1516

Query  524   PSL--SLPRKTKDRRL  537
              ++   + R  KDR L
Sbjct  1517  KTIYKEVIRVQKDRVL  1532


>gi|50403702|sp|O95613|PCNT_HUMAN  Pericentrin (Pericentrin B) (Kendrin)
Length=3336

 Score = 42.7 bits (99),  Expect = 0.002
 Identities = 49/221 (22%), Positives = 102/221 (46%), Gaps = 17/221 (7%)

Query  365   CKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKE  424
             C+  Q+      +  E +Q+ L++  + L + E E K     LE E+GK + +   L +E
Sbjct  2614  CESRQKSEQLSRSLCEVQQEVLQLRSM-LSSKENELKAALQELESEQGKGRALQSQLEEE  2672

Query  425   CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM-------EKQ  477
               +   +  + A+ LE++ A LE ++ +++ L   L  E+     ++ ++       E  
Sbjct  2673  QLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEAL  2732

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGS-------DSKPSLSLPR  530
             L++  ++  +L+  L  E++ T +L E +   R + EQL + +       D++   +L +
Sbjct  2733  LAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQ  2792

Query  531   KTKDR--RLVSISVGTEGTVTRSVACQTDLVTENADHMKKL  569
             K K+   R+V +    E    +++  Q  L  E   H + L
Sbjct  2793  KLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEAL  2833


 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 66/304 (21%), Positives = 136/304 (44%), Gaps = 50/304 (16%)

Query  230   KEPAPAVREASPSWRSVVRWPTPSMIIISRKKEFDVDTLSKS---------ELRMLLSVM  280
             +E A +V++   + ++VVR    S +  SR+K    + LS+S         +LR +LS  
Sbjct  2589  QEKANSVQKLLAAEQTVVR-DLKSDLCESRQKS---EQLSRSLCEVQQEVLQLRSMLSSK  2644

Query  281   EGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEA  340
             E EL+A      AL+EL+   G         R  +  ++E   R         LQR+ ++
Sbjct  2645  ENELKA------ALQELESEQG-------KGRALQSQLEEEQLRH--------LQRESQS  2683

Query  341   GAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEH  400
                 +E +       + LE   A   ++   +  +  A ++ QK+L +E  + +AL  + 
Sbjct  2684  AKALEELR-------ASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQE  2736

Query  401   KKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeel  460
             +   + L+++    K   L L +  +       + +Q+ ++  A + ++ +  + L ++L
Sbjct  2737  RSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQE--ACVHQDTQAHHALLQKL  2794

Query  461   SAEKRRSTEMEAQMEKQLSEFDTEREQLRAK-------LNREEAHTTDLKEEIDKMRKMI  513
               EK R  +++A +EK   +    ++QL A+       L RE+  +  LK  ++ +    
Sbjct  2795  KEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQK  2854

Query  514   EQLK  517
              +L+
Sbjct  2855  RELR  2858


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 42/184 (22%), Positives = 79/184 (42%), Gaps = 20/184 (10%)

Query  383   QKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDV  442
             +K+   +  +   + ++H++L   L+EE     ++ L L K    L G  +E A  L++V
Sbjct  1292  EKEFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETAD-LKEV  1350

Query  443   MAkleeekkktneleeelSAEKRRSTEMEA---QMEKQLSEFDTEREQLRAKLNREEAHT  499
             +A  E              +E R   E+E+   Q+++   E    RE+     +R EA  
Sbjct  1351  LAGKE-------------DSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATA  1397

Query  500   TDLKEEIDKMRKMIEQL-KRGSDSKPSLSLPRKT--KDRRLVSISVGTEGTVTRSVACQT  556
             TD +     +RK +E L K  S+++      R       +++   +  + +  R  A Q 
Sbjct  1398  TDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQA  1457

Query  557   DLVT  560
             + VT
Sbjct  1458  EAVT  1461


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 32/138 (23%), Positives = 66/138 (47%), Gaps = 21/138 (15%)

Query  380   ESRQKKLEMEKLQLQALEQEH---KKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEA  436
             ES  +++ M++ +++ LE+ +   +K  A+L+EE  K K +V  L ++      +V+++ 
Sbjct  1551  ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQD-----KEVLKKQ  1605

Query  437   QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREE  496
             Q    ++A   +         E  S       E++ ++        T+R  LR      E
Sbjct  1606  QMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEV--------TQRALLR-----RE  1652

Query  497   AHTTDLKEEIDKMRKMIE  514
             +   DLKE+++KM+  +E
Sbjct  1653  SEVLDLKEQLEKMKGDLE  1670


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 33/161 (20%), Positives = 66/161 (40%), Gaps = 24/161 (14%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             K++ E+ SA+  A    Q+  E    +LQ L++ H++    +  E     Q  L      
Sbjct  876   KEITEKFSAEQDAF--LQEAQEQHARELQLLQERHQQQLLSVTAELEARHQAAL------  927

Query  426   KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
                 G++    +  +  +      + +T    +  + E R  + +++     LSEF T R
Sbjct  928   ----GELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIR  983

Query  486   EQLRAKL------------NREEAHTTDLKEEIDKMRKMIE  514
             E+ R  L             ++  H T L +E++K+++  E
Sbjct  984   EEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE  1024


>gi|45645212|sp|Q9Y2X7|GIT1_HUMAN  ARF GTPase-activating protein GIT1 (G protein-coupled receptor 
kinase-interactor 1) (GRK-interacting protein 1) (Cool-associated 
and tyrosine-phosphorylated protein 1) (Cat-1)
Length=761

 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 31/97 (31%), Positives = 47/97 (48%), Gaps = 1/97 (1%)

Query  983   DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAAD-KNGFTPLCAAAAQGHFECVE  1041
             D   + +D    L+S+ + G+ +    LLS  AQ N    + G TPL  AA  G     E
Sbjct  125   DDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAE  184

Query  1042  LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             LL+ Y A+       G+TP+  A + G+ E  + L+E
Sbjct  185   LLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE  221


 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 0/84 (0%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             L  +   GN+     LL+       +  E G + L+ AAK G T    LL+   A   + 
Sbjct  137   LHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSP  196

Query  1021  DKNGFTPLCAAAAQGHFECVELLI  1044
             D NG TP+  A   GH E  E L+
Sbjct  197   DVNGRTPIDYARQAGHHELAERLV  220


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 3/77 (3%)

Query  1028  LCAAAAQGHFE-CVELL-ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSV  1085
             L ++   G+ E C+ LL +   AN  H  + G TPL++A K G     +LL+  G +   
Sbjct  137   LHSSVRTGNLETCLRLLSLGAQANFFHP-EKGTTPLHVAAKAGQTLQAELLVVYGADPGS  195

Query  1086  KTTDGWTPVHAAVDTGN  1102
                +G TP+  A   G+
Sbjct  196   PDVNGRTPIDYARQAGH  212


>gi|74739242|sp|Q4ZG46|RBP24_HUMAN  Ran-binding protein 2-like 4 (RanBP2L4)
Length=1583

 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 69/356 (19%), Positives = 140/356 (39%), Gaps = 46/356 (12%)

Query  204   DKISKPPLRRLNVVPLTTFKQIKEIGKEPAPAVREASPSWRSVVRWPTPSMIIISRKKEF  263
             D ++K P  + +  PL++ K+++E  +      +E       +       ++ +  KKE 
Sbjct  829   DSLAKSPSVKND--PLSSVKELEEKIENLEKECKEKEEKINKI------KLVAVKAKKEL  880

Query  264   DVDTLSKSELRMLLSVMEGELEARDLVIEALREL-KWFTGIKTAKWENARRKEVFIQERY  322
             D    S+ E + +   +E     +D +  ++R+L +     K    E  ++ E    E+ 
Sbjct  881   DS---SRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE  937

Query  323   GRFNLNDPFLALQRDYEAGAGDKEK-KPVCTNPLSILEAVMAHCKKMQERMSAQLAAAES  381
                N       L R         E       + L+ +E + ++ K ++ ++     A   
Sbjct  938   RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM  997

Query  382   RQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLED  441
               K+LE EKLQ +   +EH      LEE       + + L K+ KQL     +  Q+LE 
Sbjct  998   VDKELEAEKLQKEQKIKEHATTVNELEE-------LQVQLQKQKKQLQ----KTMQELEL  1046

Query  442   VMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
             V                      ++  +    M  ++++++   ++L  KL  +     D
Sbjct  1047  V----------------------KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIED  1084

Query  502   LKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTD  557
             L++EI   ++  E L+    S  S     + K+ ++  + V T+  +  S   +TD
Sbjct  1085  LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETD  1140


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 63/304 (20%), Positives = 123/304 (40%), Gaps = 23/304 (7%)

Query  255   IIISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALR-ELKWFTGIKTAKWENARR  313
             +++  KKE      ++++  +L + ++GELEA    +E  + +L   T  K    E+ + 
Sbjct  1123  LLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKT  1182

Query  314   KEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMS  373
                  Q     +       ALQ +  A    K ++   T+     +  + +  K Q+  S
Sbjct  1183  SAEQHQRTLSAYQQR--VTALQEECRAA---KAEQATVTSEFESYKVRVHNVLKQQKNKS  1237

Query  374   ---AQLAAAESRQKKLEMEKLQLQA-LEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS  429
                A+   A+  ++ LEM   QL+  L+     L   + E +    +   +L +  K L 
Sbjct  1238  MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQ  1297

Query  430   GKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLR  489
               V +EA+  E + +   E            S   +  +++ +Q E   + F   R+Q+R
Sbjct  1298  ETVSKEAELREKLCSIQSENMMMK-------SEHTQTVSQLTSQNEVLRNSF---RDQVR  1347

Query  490   AKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTK---DRRLVSISVGTEG  546
                         L++++ KM   + QLK    ++  +S  +  K   +RR   + +    
Sbjct  1348  HLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMH  1407

Query  547   TVTR  550
             TVTR
Sbjct  1408  TVTR  1411


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 27/140 (19%), Positives = 69/140 (49%), Gaps = 4/140 (2%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             K++ ++++ +    E  +++++++K + + L++E   L + +++   KN ++  +LVK  
Sbjct  1069  KELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTK  1128

Query  426   KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
             K+L+    +  Q   D +      K +    ++++   K +  E+ ++  K      T  
Sbjct  1129  KELA----DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSA  1184

Query  486   EQLRAKLNREEAHTTDLKEE  505
             EQ +  L+  +   T L+EE
Sbjct  1185  EQHQRTLSAYQQRVTALQEE  1204


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 39/195 (20%), Positives = 83/195 (42%), Gaps = 36/195 (18%)

Query  357  ILEAVMAHCKKMQERMSAQLAAAESRQ--KKLEMEKLQLQALEQEHKKLAARLEEERGKN  414
            +LE   A+ K   E  +  +   E  Q   K E+   + +   +EH+ L   LE++  ++
Sbjct  760  LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD  819

Query  415  KQVVLMLVKECKQLSGKV----IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM  470
            ++  L+L+K+    S  V    +   ++LE                      EK  + E 
Sbjct  820  RRAELILLKDSLAKSPSVKNDPLSSVKELE----------------------EKIENLEK  857

Query  471  EA-QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK-------RGSDS  522
            E  + E+++++      + + +L+     T  +KEE++ +R   +QL        +G++S
Sbjct  858  ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES  917

Query  523  KPSLSLPRKTKDRRL  537
              +L L  + +  +L
Sbjct  918  YKNLLLEYEKQSEQL  932


>gi|17375490|sp|Q14203|DYNA_HUMAN  Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) 
(p150-glued) (p135)
Length=1278

 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 36/161 (22%), Positives = 81/161 (50%), Gaps = 23/161 (14%)

Query  379  AESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQK  438
            AES Q+++E  K ++  L  + + L A +EE +G +       +K+ ++ + ++ +   +
Sbjct  318  AESLQQEVEALKERVDELTTDLEILKAEIEE-KGSDGAASSYQLKQLEEQNARLKDALVR  376

Query  439  LEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDT---EREQLRAKLNRE  495
            + D+                  S+EK+   +++  MEK+  E +    +RE+L+ +L++ 
Sbjct  377  MRDLS-----------------SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQA  419

Query  496  EAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRR  536
            E+   +LKE++D      E ++  +D   +L+L  K ++ R
Sbjct  420  ESTIDELKEQVDAALGAEEMVEMLTDR--NLNLEEKVRELR  458


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 11/141 (7%)

Query  381   SRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLE  440
             S+   +E+    L+A   + + L  +LE+     ++ V+  +K+  ++ G+ + EA    
Sbjct  919   SKPPPVELRAAALRAEITDAEGLGLKLED-----RETVIKELKKSLKIKGEELSEA----  969

Query  441   DVMAkleeekkktneleeelSAEK--RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAH  498
             +V   L E+K  +   + +   EK   R  E +A + K+  EF+   + L+A +++ EA 
Sbjct  970   NVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAE  1029

Query  499   TTDLKEEIDKMRKMIEQLKRG  519
               +LK+ ++   K   +  RG
Sbjct  1030  KAELKQRLNSQSKRTIEGLRG  1050


>gi|62287118|sp|Q96CV9|OPTN_HUMAN  Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting 
protein) (FIP-2) (Huntingtin-interacting protein HYPL) 
(NEMO-related protein) (Transcription factor IIIA-interacting 
protein) (TFIIIA-IntP)
Length=577

 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 44/191 (23%), Positives = 88/191 (46%), Gaps = 8/191 (4%)

Query  310  NARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQ  369
            N +   +F + +     L++  L  +R  E     + K     + L+  + ++   KK++
Sbjct  303  NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE  362

Query  370  ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS  429
             ++ + L+  +  Q K E EK +L  L+  H KL   L+E     K +  +  KE +++ 
Sbjct  363  LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKL---LQEHNNALKTIEELTRKESEKVD  419

Query  430  GKVIEE-AQKL---EDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
              V++E ++KL   E  +A  + +  +  +   +   +    T + AQME   S+F  ER
Sbjct  420  RAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAER  479

Query  486  EQLRAKLNREE  496
               R K++ E+
Sbjct  480  -AAREKIHEEK  489


>gi|71152964|sp|Q8WUF5|IASPP_HUMAN  RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein 
iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1)
Length=828

 Score = 42.4 bits (98),  Expect = 0.002
 Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query  960   LLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             LL  AA  G + ++   + E   D +   E+G +AL++A    +   V  L++A A VN+
Sbjct  630   LLLDAALTGELEVVQQAVKEMN-DPSQPNEEGITALHNAICGANYSIVDFLITAGANVNS  688

Query  1020  ADKNGFTPL-CAAAAQGHFECVELL  1043
              D +G+TPL CAA+      C+ L+
Sbjct  689   PDSHGWTPLHCAASCNDTVICMALV  713


 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 24/90 (26%), Positives = 37/90 (41%), Gaps = 0/90 (0%)

Query  1023  NGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN  1082
             N    L  AA  G  E V+  +    + +   + G T L+ A    N   +  L+ AG N
Sbjct  626   NPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGAN  685

Query  1083  RSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
              +   + GWTP+H A    +      L+ H
Sbjct  686   VNSPDSHGWTPLHCAASCNDTVICMALVQH  715


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 26/99 (26%), Positives = 42/99 (42%), Gaps = 1/99 (1%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA  1054
             L  AA  G  + V+  +      +  ++ G T L  A    ++  V+ LI+  AN+N   
Sbjct  631   LLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPD  690

Query  1055  DGGQTPLYLACK-NGNKECIKLLLEAGTNRSVKTTDGWT  1092
               G TPL+ A   N    C+ L+       +   +DG T
Sbjct  691   SHGWTPLHCAASCNDTVICMALVQHGAAIFATTLSDGAT  729


>gi|29427834|sp|Q8N4C8|MINK1_HUMAN  Misshapen-like kinase 1 (Mitogen-activated protein kinase kinase 
kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK 
kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK 
family kinase MiNK)
Length=1332

 Score = 42.0 bits (97),  Expect = 0.003
 Identities = 54/272 (19%), Positives = 111/272 (40%), Gaps = 37/272 (13%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQL  428
            QE  S   A  + +Q + + ++     ++    +   R+EE++ + ++V     +E +Q 
Sbjct  360  QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR  419

Query  429  SGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQL  488
              +  E+ ++LED+ A                  E+RR  E E + +++  E   + E+L
Sbjct  420  KLQEKEQQRRLEDMQA--------------LRREEERRQAEREQEYKRKQLEEQRQSERL  465

Query  489  RAKLNREEAHTTDL--KEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEG  546
            + +L +E A+   L  +++  +++K  +Q     D KP     R         ++   + 
Sbjct  466  QRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGR--------GMNPADKP  517

Query  547  TVTRSVACQTDLVTENADHMKKLPLTMPVKPSTGS----PLVSANAKGSVCTSATMARPG  602
               R V  +T +     +  +  PL      STG     P  S    G +  +  M RP 
Sbjct  518  AWAREVEERTRM-----NKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPV  572

Query  603  IDRQASYGDLIGASVP----AFPPPSANKIEE  630
              ++  +  L+   VP    A P P +  +++
Sbjct  573  EPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQD  604


>gi|17376322|sp|Q14161|GIT2_HUMAN  ARF GTPase-activating protein GIT2 (G protein-coupled receptor 
kinase-interactor 2) (GRK-interacting protein 2) (Cool-interacting 
tyrosine-phosphorylated protein 2) (CAT2) (CAT-2)
Length=759

 Score = 41.6 bits (96),  Expect = 0.003
 Identities = 30/97 (30%), Positives = 47/97 (48%), Gaps = 1/97 (1%)

Query  983   DINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAAD-KNGFTPLCAAAAQGHFECVE  1041
             D + + +D    L+S+ + G+ +    LLS  AQ N    + G TPL  A+  G     E
Sbjct  125   DDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAE  184

Query  1042  LLISYDANINHAADGGQTPLYLACKNGNKECIKLLLE  1078
             LL  Y A+       G+TP+  A + G+ E  + L+E
Sbjct  185   LLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE  221


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 3/77 (3%)

Query  1028  LCAAAAQGHFE-CVELL-ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSV  1085
             L ++   G+ E C+ LL +   AN  H  + G TPL++A K G     +LL   G +   
Sbjct  137   LHSSVRTGNLETCLRLLSLGAQANFFHP-EKGNTPLHVASKAGQILQAELLAVYGADPGT  195

Query  1086  KTTDGWTPVHAAVDTGN  1102
             + + G TPV  A   G+
Sbjct  196   QDSSGKTPVDYARQGGH  212


>gi|30912747|sp|Q9P2S6|ANKY1_HUMAN  Ankyrin repeat and MYND domain protein 1 (Testis-specific ankyrin-like 
protein 1) (Zinc-finger MYND domain protein 13)
Length=941

 Score = 41.6 bits (96),  Expect = 0.003
 Identities = 23/67 (34%), Positives = 33/67 (49%), Gaps = 0/67 (0%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA  1054
             +  A +  H    R+L    A  + AD  G+T L AAA   H + V LL+   A++N  +
Sbjct  264   ILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCS  323

Query  1055  DGGQTPL  1061
             D G T L
Sbjct  324   DEGLTAL  330


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 20/64 (31%), Positives = 30/64 (46%), Gaps = 0/64 (0%)

Query  965   AAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNG  1024
             A +GN   +  +L +     + +   G++ L +AA + H D V LLL   A VN     G
Sbjct  267   AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG  326

Query  1025  FTPL  1028
              T L
Sbjct  327   LTAL  330


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 8/87 (9%)

Query  1038  ECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDG-WTPVHA  1096
             + V LL+S+ AN N     G +PL L+  +GN+  +K LL  G + ++  T G  + +  
Sbjct  677   DIVRLLLSHGANPN-LLWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCV  735

Query  1097  AVD-----TGNVDSLKLLMYHRIPAHG  1118
             A D       N+DS KL +  R+ +HG
Sbjct  736   ACDLTYEHQRNMDS-KLALIDRLISHG  761


>gi|42558942|sp|O75334|LIPA2_HUMAN  Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f 
polypeptide-interacting protein alpha-2) (PTPRF-interacting 
protein alpha-2)
Length=1257

 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 72/333 (21%), Positives = 141/333 (42%), Gaps = 53/333 (15%)

Query  229  GKEPAPAVREASPSWRSVVRWPTPSMII----ISRKKEFDVDTLSKSELRMLLSVMEGEL  284
            G EP   V E   S  S+      S I+    +  K+ +++  + +    +   V E E 
Sbjct  244  GMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQ  303

Query  285  EA----RDLVIEALRELKWFTGIKTA--KWENARRKEVFIQERYGRFNLNDPFLALQRDY  338
            EA    +DL+       K+   I+ A  + E+   +   +++RY         L+ QR+ 
Sbjct  304  EAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRY---------LSAQRES  354

Query  339  EAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQ  398
             +     +K     N L+  EA++   ++   ++  +L  AE   +KL+    + + L +
Sbjct  355  TSIHDMNDK---LENELANKEAILRQMEEKNRQLQERLELAE---EKLQQTMRKAETLPE  408

Query  399  EHKKLAARL------EEERGKNKQVVLMLVKECKQLSGKVIEEAQKLE-----DVMAkle  447
               +LA R+      EE  G        + +  + L G++ E+ Q+L+     + M +  
Sbjct  409  VEAELAQRIAALTKAEETHGN-------IEERMRHLEGQLEEKNQELQRARQREKMNEEH  461

Query  448  eekkktneleeelSAEKRRSTEMEAQM----EKQ--LSEFDTEREQLRAKLNREEAHTTD  501
             ++           + +R    ++ +M    EK   + E +T R+ L   L+ +E+    
Sbjct  462  NKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKES----  517

Query  502  LKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
            L EEI+K+R  ++QLK  + S    ++PR   D
Sbjct  518  LAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLD  550


>gi|33302627|sp|Q15643|TRIPB_HUMAN  Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated 
microtubule-binding protein 210) (GMAP-210) (Trip230) 
(Clonal evolution related gene on chromosome 14)
Length=1979

 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 67/291 (23%), Positives = 118/291 (40%), Gaps = 58/291 (19%)

Query  267  TLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFN  326
            +L K+ +   L + +GE+EA         EL W    K    E A + E  I+E     N
Sbjct  704  SLEKNTIVETLKMEKGEIEA---------ELCW---AKKRLLEEANKYEKTIEELSNARN  751

Query  327  LNDPFLALQRDY--------------------EAGAGDKEKKPVCTNPLS-------ILE  359
            LN   L L+ ++                    +     KE K V ++ L        ++ 
Sbjct  752  LNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLIN  811

Query  360  AVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEE--------ER  411
                  +K++ER S      +   + L   ++  Q +E++ + L +  EE        ER
Sbjct  812  KKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELER  871

Query  412  GKNKQVVLMLVKECKQLSG--KVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTE  469
             + +Q     V + K L    ++  E  +L  +   LEEE K   ++ E+ +  K +  +
Sbjct  872  LREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQ  931

Query  470  MEAQMEKQLSEFDTEREQLRAKLNREEAHTT---DLKEEIDKMRKMIEQLK  517
               + +K++ EF  + EQ+ A       HT    +  EEI  ++K IEQ+K
Sbjct  932  SLQEQKKEMDEFRYQHEQMNA------THTQLFLEKDEEIKSLQKTIEQIK  976


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 49/223 (21%), Positives = 94/223 (42%), Gaps = 44/223 (19%)

Query  356  SILEAVMAHCKKMQERMSAQLAAAESRQK-----KLEMEKLQLQALEQEHKKLAARLEEE  410
            ++L+   A  + +++ +S      E+ +K     K+E EKL L   +  H+     LEE 
Sbjct  642  TLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQ-----LEEC  696

Query  411  RGKNKQVVL---MLVKECKQLSGKV-----------IEEAQKLEDVM-----Akleeekk  451
               N Q+ L    +V+  K   G++           +EEA K E  +     A+      
Sbjct  697  LAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSA  756

Query  452  ktneleeelSAEKRRSTEMEAQMEKQLSEFDT--------------EREQLRAKLNREEA  497
               E E  +   +++  E+ A+++K + + DT              E++QL   +N++E 
Sbjct  757  LQLEHEHLIKLNQKKDMEI-AELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEI  815

Query  498  HTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSI  540
                LKE   K+++ +++  +       L    + KDR L S+
Sbjct  816  FIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSM  858


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 39/165 (23%), Positives = 66/165 (40%), Gaps = 30/165 (18%)

Query  367   KMQERMSAQLAAAESRQKKLEMEKLQLQ-ALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             K ++  + QL+ ++ + K+  +    LQ  LE   ++  A    E  K KQ++    K  
Sbjct  1650  KQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNA  1709

Query  426   KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
             + L GKVI   + L++  A L+                  R TE     E+Q+ E   + 
Sbjct  1710  ENLEGKVISLQECLDEANAALD---------------SASRLTEQLDVKEEQIEELKRQN  1754

Query  486   EQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPR  530
             E LR             +E +D ++K +  L   S+ K    L R
Sbjct  1755  E-LR-------------QEMLDDVQKKLMSLANSSEGKVDKVLMR  1785


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 66/297 (22%), Positives = 123/297 (41%), Gaps = 51/297 (17%)

Query  258  SRKKEFD-VDTLSKSE---LRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARR  313
            SR KE + +  + +SE   L+ L + +E + EA ++ I+            T+     ++
Sbjct  52   SRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQ---------STSYRNQLQQ  102

Query  314  KEVFIQERYGR-FNLNDPFLALQ---RDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQ  369
            KEV I     R   L D  L LQ   +   +GAG     P  T   S    +  H     
Sbjct  103  KEVEISHLKARQIALQDQLLKLQSAAQSVPSGAG----VPATTASSSFAYGISHHPSAFH  158

Query  370  ERMSAQLAAAESRQKKLEMEKLQLQALEQE--HKKLAARLEEERGKNKQ------VVLML  421
            +          S Q+++     ++  LE E  H +  A+  + +G +         +  +
Sbjct  159  DD-DMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNI  217

Query  422  VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEF  481
            +KE KQ   + I++ Q    V+                 +A +++ TE+  +  ++LS++
Sbjct  218  IKELKQNRSQEIDDHQHEMSVLQ----------------NAHQQKLTEISRRHREELSDY  261

Query  482  DTEREQLRAKLNREEAHT--TDLKEEIDKMRKMIE--QLKRGSDSKPSLSLPRKTKD  534
            +   E+L   L +  +    TDL  +I +M+K I+  Q+++   +K    L  K KD
Sbjct  262  EERIEELENLLQQGGSGVIETDL-SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKD  317


>gi|13431724|sp|Q9Y623|MYH4_HUMAN  Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin 
heavy chain IIb) (MyHC-IIb)
Length=1939

 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 50/197 (25%), Positives = 84/197 (42%), Gaps = 15/197 (7%)

Query  334   LQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQ  392
             L+ + EA    + K     + LS  LE +    ++     SAQ+   + R+ + +  +  
Sbjct  1122  LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIELNKKREAEFQKMRRD  1181

Query  393   LQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkk  452
             L+    +H+  AA L   R K+   V  L K+   L        QKLE   ++L+ E   
Sbjct  1182  LEESTLQHEATAAAL---RKKHADSVAELGKQIDSLQ----RVKQKLEKEKSELKMEIND  1234

Query  453   tneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEA-----HTT--DLKEE  505
                  E +S  K    +M   +E QLSE  T+ E+ +  +N   A     HT   +   +
Sbjct  1235  LASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQ  1294

Query  506   IDKMRKMIEQLKRGSDS  522
             +D+   M+ QL RG  +
Sbjct  1295  LDEKDAMVSQLSRGKQA  1311


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 42/165 (25%), Positives = 74/165 (44%), Gaps = 10/165 (6%)

Query  376   LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL---MLVKECKQLSGKV  432
             LA AE R  +L   K+QL+A   + K++  R E+E   N ++      L  EC +L    
Sbjct  902   LADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEINAELTAKKRKLEDECSELK---  955

Query  433   IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKL  492
              ++   LE  +AK+E+EK  T    + L+ E     E  A++ K+        +Q    L
Sbjct  956   -KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL  1014

Query  493   NREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
               EE     L +   K+ + ++ L+   + +  L +  +   R+L
Sbjct  1015  QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKL  1059


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 59/253 (23%), Positives = 110/253 (43%), Gaps = 28/253 (11%)

Query  303   IKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVM  362
             IKT     A+ KEV  +       +N    A +R  E    + +K       +  LE  +
Sbjct  913   IKTKIQLEAKIKEV-TERAEDEEEINAELTAKKRKLEDECSELKKD------IDDLELTL  965

Query  363   AHCKKMQ-------ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNK  415
             A  +K +       + ++ ++A  +    KL  EK   +AL++ H++    L+ E  K  
Sbjct  966   AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK---KALQEAHQQTLDDLQMEEDK--  1020

Query  416   QVVLMLVKECKQLSGKV--IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ  473
               V  L K   +L  +V  +E + + E  +    E  K+  E + +L+ E    TE + Q
Sbjct  1021  --VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQ  1078

Query  474   -MEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD----SKPSLSL  528
              + ++L + + E   L+ K+  E+A    L+++I +++  IE+L+   +    S+     
Sbjct  1079  QLNEKLKKKEFEMSNLQGKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAEK  1138

Query  529   PRKTKDRRLVSIS  541
              R    R L  IS
Sbjct  1139  QRSDLSRELEEIS  1151


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 30/131 (22%), Positives = 65/131 (49%), Gaps = 6/131 (4%)

Query  399  EHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnelee  458
            E +K  A ++EE  K K+ +     + K+L  K++   Q+  D+  +++ E     + EE
Sbjct  848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE  907

Query  459  elSAEKRRSTEMEAQMEKQLSEFDTERE---QLRAKLNREEAHTTDLKEEIDKMR---KM  512
                  +   ++EA++++     + E E   +L AK  + E   ++LK++ID +      
Sbjct  908  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK  967

Query  513  IEQLKRGSDSK  523
            +E+ K  +++K
Sbjct  968  VEKEKHATENK  978


>gi|12644407|sp|Q13574|DGKZ_HUMAN  Diacylglycerol kinase zeta (Diglyceride kinase zeta) (DGK-zeta) 
(DAG kinase zeta)
Length=1117

 Score = 41.2 bits (95),  Expect = 0.004
 Identities = 42/156 (26%), Positives = 62/156 (39%), Gaps = 5/156 (3%)

Query  941   SLTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAK  1000
             S TP  + G  AP  G   +    AA+ N       L+  G D+ +  E   + L+ A  
Sbjct  965   SPTPRSLQGDAAPPQGEELI---EAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVS  1021

Query  1001  NGHTDCVRLLLSAEAQ--VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQ  1058
              G  D VR LL       ++A ++NG T L  AAA G       ++   A++      G 
Sbjct  1022  TGSKDVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGD  1081

Query  1059  TPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPV  1094
             TP   A K  + E    L      + ++  D  T V
Sbjct  1082  TPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV  1117


>gi|74753268|sp|Q9UDT6|CYLN2_HUMAN  Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) 
(CLIP-115) (Williams-Beuren syndrome chromosome region 4 protein)
Length=1046

 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 45/158 (28%), Positives = 79/158 (50%), Gaps = 12/158 (7%)

Query  368  MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ  427
            + ER   +   A++     E+EK ++  L+ +H++  A  EE+  + + +V  + KE   
Sbjct  372  LAERDLERAEVAKATSHICEVEK-EIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVD  430

Query  428  LSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME-------AQMEKQLSE  480
            LS ++ EE +K+ED+  ++EEE     +LE +   E  R  E+E       AQ E+ L E
Sbjct  431  LSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRE  490

Query  481  FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
                R    A    E++    L+EE+   R  IE+L++
Sbjct  491  LADNRLTTVA----EKSRVLQLEEELTLRRGEIEELQQ  524


>gi|50400858|sp|Q14980|NUMA1_HUMAN  Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen)
Length=2115

 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 63/286 (22%), Positives = 118/286 (41%), Gaps = 25/286 (8%)

Query  355   LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKN  414
             LS  E    H K   E+      A + + ++L+ +   L+ L++E+K+L A   E  G  
Sbjct  1600  LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE-AERLGHE  1658

Query  415   KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM  474
              Q   +  KE +Q    +  + + LE  +A  +++ +   + +    A K R  + + Q+
Sbjct  1659  LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQL  1718

Query  475   EKQLSEFDTEREQ-----LRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSL-  528
             +  +   D   E+     + +KL R +   T +  E      + ++L    +S  SL   
Sbjct  1719  DLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGE--PASPISQRLPPKVESLESLYFT  1776

Query  529   PRKTKDRRLVSISVGTEGTV-------TRSVACQTDLVTENADHMKKLPLTMPVKP----  577
             P   + +  +  S+ + G V       TRS   +T  +  N    KKL +  P       
Sbjct  1777  PIPARSQAPLESSLDSLGDVFQDSGRKTRSARRRTTQII-NITMTKKLDVEEPDSANSSF  1835

Query  578   -STGSPLVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPAFPP  622
              ST S   S  +  +  ++ ++AR G      YG+    S+P + P
Sbjct  1836  YSTRSAPASQASLRATSSTQSLARLG---SPDYGNSALLSLPGYRP  1878


 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 56/233 (24%), Positives = 92/233 (39%), Gaps = 29/233 (12%)

Query  334  LQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERM----SAQLA-AAESRQKKLEM  388
            LQ+  +A  G + +    ++ L   E  +    + QE      + QLA AAE R+  L  
Sbjct  539  LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRE  598

Query  389  EKLQLQALEQEHKKLAARLE----------EERGKNKQVVLMLVKECKQLSGKV------  432
                L+ LE   K+ AA+LE          E R   +  V    +E  +LS KV      
Sbjct  599  RDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC  658

Query  433  IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKL  492
            +E A++ +        E +     E++ + EK R  + + Q+++QL       +  +  L
Sbjct  659  VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL  718

Query  493  NREEAHTTDLKEEIDK--------MRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
              E+    D  EE  +         R ++EQ KR           RK  + RL
Sbjct  719  EEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARL  771


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 64/308 (20%), Positives = 125/308 (40%), Gaps = 62/308 (20%)

Query  223   KQIKEIGKEPAPAVREASPSWRSVVRWPTPSMIIISRKKEFDVDTLSKSELRMLLSVMEG  282
             +Q+  + +E   A +E   +   V    + S + ISR++  ++  L  +  R L  V E 
Sbjct  833   EQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQN-ELAELHANLARALQQVQEK  891

Query  283   ELEARDLV--IEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEA  340
             E+ A+ L   +  L+E    T  + A+ E   RK    QE   R  + +P  A  R  E 
Sbjct  892   EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE-  950

Query  341   GAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEH  400
                +++ +  C+   ++                 Q    E+ Q   E+E+L+   +E + 
Sbjct  951   WLEEQQGRQFCSTQAAL-----------------QAMEREAEQMGNELERLRAALMESQG  993

Query  401   KKLAARLEEERGKNKQVVLMLVKECKQLSGKV-IEEAQKLEDVMAkleeekkktneleee  459
             ++     +EERG+ ++ V  L +E  +    + +E+A + E  M                
Sbjct  994   QQ-----QEERGQQEREVARLTQERGRAQADLALEKAARAELEM----------------  1032

Query  460   lSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLK----------EEIDKM  509
                       ++  + +Q  EF T +E L   L  +E    +L           +E++++
Sbjct  1033  ---------RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL  1083

Query  510   RKMIEQLK  517
             R+ ++QLK
Sbjct  1084  RQTVKQLK  1091


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 44/200 (22%), Positives = 90/200 (45%), Gaps = 31/200 (15%)

Query  345  KEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLA  404
            +EK  +     ++ E++      ++E       A E +Q+ +   K + ++L ++HK+  
Sbjct  695  QEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER  754

Query  405  ARLEEERG--KNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSA  462
              LEEER   K  +  L  + E  Q   +V+   ++L + MA                 A
Sbjct  755  KELEEERAGRKGLEARLQQLGEAHQAETEVLR--RELAEAMA-----------------A  795

Query  463  EKRRSTEMEAQMEKQLSEF-----DTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
            +    +E E Q+ K+++ +     D+++E+ +     +E   T LKEE +K R+ +++ K
Sbjct  796  QHTAESECE-QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT-LKEECEKARQELQEAK  853

Query  518  R---GSDSKPSLSLPRKTKD  534
                G +S   L + R+  +
Sbjct  854  EKVAGIESHSELQISRQQNE  873


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 53/222 (23%), Positives = 94/222 (42%), Gaps = 51/222 (22%)

Query  331  FLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEME-  389
            FL LQ+   + +G+     +  +P S +  ++   +    R+  QLA   S + +LE+E 
Sbjct  181  FLELQKVASSSSGNNF---LSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELEL  237

Query  390  ----------KLQLQALEQEHKKLA-------------ARLEEERGKNKQVVLMLVKECK  426
                        Q+  ++Q   +LA               LEE R KN+ + + L +  K
Sbjct  238  AENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLK  297

Query  427  QLSGKVIEEAQ-----------------KLEDVMAkleeekkktneleeelSAEKRRSTE  469
            Q      E++Q                 KL +  + L++ +   NEL EE S   +   E
Sbjct  298  QCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLE  357

Query  470  MEAQMEKQLSE-------FDTEREQLRAKLNREEAHTTDLKE  504
             +AQ+EK+LS         + + E L+ KL++ E H + L++
Sbjct  358  KQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQD  399


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 38/184 (20%)

Query  358  LEAVMAHCKKMQERMSA-----QLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG  412
            L    +H +++Q+ ++        A  E  +K+ ++EK +L A  Q+ K L  + E  +G
Sbjct  327  LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK-ELSAALQDKKCLEEKNEILQG  385

Query  413  KNKQV---VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTE  469
            K  Q+   +  L     Q  G+V+ +  +LE +                    E      
Sbjct  386  KLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL------------------KQEAATLAA  427

Query  470  MEAQMEKQLSEFDTEREQLRAKLNREEAH-----------TTDLKEEIDKMRKMIEQLKR  518
               Q++ ++   +TER Q  AKL  E  H            TDL+  I  + +  E+L++
Sbjct  428  NNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ  487

Query  519  GSDS  522
             S +
Sbjct  488  ASQA  491


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 33/162 (20%), Positives = 80/162 (49%), Gaps = 15/162 (9%)

Query  366   KKMQERMSAQLAAAESR----QKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLML  421
             +K  + ++A  A AE+R    Q++ +    +L+ +  +++    ++ EER + ++    L
Sbjct  1474  EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKL  1533

Query  422   VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEF  481
               + +QL     E+ +++E++  KL +             A K +  +++A ++ Q  E 
Sbjct  1534  TAQVEQLEVFQREQTKQVEELSKKLADSD----------QASKVQQQKLKA-VQAQGGES  1582

Query  482   DTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
               E ++L+A+LN  +A  +  ++  +  +  +E+ K   D+K
Sbjct  1583  QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK  1624


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 33/126 (26%), Positives = 56/126 (44%), Gaps = 20/126 (15%)

Query  393  LQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEA--QKLEDVMAkleeek  450
            LQ  + + ++L  +L +ER    ++ L L +  K L+ K  + A  Q+  D +A L    
Sbjct  209  LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLN---  265

Query  451  kktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMR  510
                        EK+ ++ +E    K+L E   + E L  +L+       DLK E  +M 
Sbjct  266  ------------EKQAASPLEP---KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMD  310

Query  511  KMIEQL  516
            + I QL
Sbjct  311  RKINQL  316


>gi|30580364|sp|Q9BV73|CEP2_HUMAN  Centrosomal protein 2 (Centrosomal Nek2-associated protein 1) 
(C-NAP1) (Centrosome protein 250) (Centrosome-associated protein 
CEP250)
Length=2442

 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 55/261 (21%), Positives = 111/261 (42%), Gaps = 34/261 (13%)

Query  265   VDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARR--KEVFIQERY  322
             ++TL +++  +  +  + E   +D+ ++ L+E +  TGI   + + A+R  KE   Q R 
Sbjct  931   LETLLQTQKELADASQQLERLRQDMKVQKLKEQET-TGILQTQLQEAQRELKEAARQHR-  988

Query  323   GRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESR  382
                   D   ALQ +  +   DK                    +K  E + +QL A +  
Sbjct  989   ------DDLAALQEESSSLLQDK-----------------MDLQKQVEDLKSQLVAQDDS  1025

Query  383   QKKLEMEKLQLQALEQEHKKLAARLEEERGK------NKQVVLMLVKECKQLSGKVIEEA  436
             Q+ +E E  +     QE+ ++   LE E+         K+  L++++E   +  + +   
Sbjct  1026  QRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSAL  1085

Query  437   -QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNRE  495
              Q +++   + +E   +   L +E+  ++      EAQ+ ++L       +QLRA L  +
Sbjct  1086  RQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQ  1145

Query  496   EAHTTDLKEEIDKMRKMIEQL  516
             EA    L+  +      +E L
Sbjct  1146  EAKAAQLQLRLRSTESQLEAL  1166


 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 44/222 (19%), Positives = 95/222 (42%), Gaps = 39/222 (17%)

Query  356   SILEAVMAHCKKMQERMSAQLAAAESRQKKL-EMEKLQLQALEQEHK-----KLAARLEE  409
             ++LE  +   +K  + + +Q    +  +K+L  +E L L+  E  HK     KL   LE 
Sbjct  1522  NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEG  1581

Query  410   ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTE  469
             +R   +  +  L  + ++ S ++  ++ ++ D+                     +  ST 
Sbjct  1582  QRETQRVALTHLTLDLEERSQELQAQSSQIHDL---------------------ESHSTV  1620

Query  470   MEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLP  529
             +  +++++  E  ++REQ+     ++E  T DL+    ++    E+++   D +      
Sbjct  1621  LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQR-----T  1675

Query  530   RKTK----DRRLVSISVGTEGTVTRSVACQTDLVTENADHMK  567
             R+TK    D   + +S+   G   R +  Q  L+ E A+  K
Sbjct  1676  RQTKILEEDLEQIKLSLRERG---RELTTQRQLMQERAEEGK  1714


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 36/164 (21%), Positives = 70/164 (42%), Gaps = 27/164 (16%)

Query  359   EAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLE----EERGKN  414
             E  +A  K +QE ++        R++++E  + Q+Q LE++ +   A LE    + + +N
Sbjct  1410  ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRN  1469

Query  415   KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM  474
             ++V          L  + I+E +K   V+             E    A + R  ++  Q 
Sbjct  1470  QEV---------DLQQEQIQELEKCRSVL-------------EHLPMAVQEREQKLTVQR  1507

Query  475   EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
             E Q+ E + +RE  R  L  +        + I+  R  ++ LK+
Sbjct  1508  E-QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK  1550


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 32/175 (18%), Positives = 74/175 (42%), Gaps = 3/175 (1%)

Query  363   AHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLV  422
             A  ++M+ +   +L  A       ++E LQ   +E   +  AA + EE  +  +  L L 
Sbjct  1332  AELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLK  1391

Query  423   KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFD  482
              E  +   +  +  Q+  ++     +  ++   L  +  AE+    E    +  Q+ E +
Sbjct  1392  NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET---LRGQIQELE  1448

Query  483   TEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
              +RE  +A L           +E+D  ++ I++L++       L +  + ++++L
Sbjct  1449  KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKL  1503


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 42/191 (21%), Positives = 87/191 (45%), Gaps = 20/191 (10%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQL-QALEQEHKKLAARLEEERGKNKQ  416
             L+A  AH ++++E +  Q    + +  + + +  QL QAL Q  ++L  + E E+   K 
Sbjct  2005  LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS  2064

Query  417   VVLMLVKEC---KQLSGKVIEE---------AQKLEDVMAkleeekkktneleeelSAEK  464
             +   + +     KQ  G+  EE          ++L+  +A+ E+E  +  E ++  + E 
Sbjct  2065  LAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEA  2124

Query  465   RRSTEMEAQMEKQLSEFDT-------EREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
                +   + ME+Q  + D+       E E+L+A L + EA   + +E+   +   + Q K
Sbjct  2125  LPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK  2184

Query  518   RGSDSKPSLSL  528
                 S   +++
Sbjct  2185  ASVSSLQEVAM  2195


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 35/155 (22%), Positives = 71/155 (45%), Gaps = 23/155 (14%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQ----VVLMLVKE  424
            QER +A    A++ Q+     + Q  A E+E  +L  + E+ER  ++Q     +  L +E
Sbjct  824  QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE  883

Query  425  CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
              +L  ++ E+  ++E + A                  E+ R+    A  + QL E + E
Sbjct  884  KMELEMRLKEQQTEMEAIQA----------------QREEERTQAESALCQMQL-ETEKE  926

Query  485  REQLRAKLNREEAHTTDLKEEIDKMRK--MIEQLK  517
            R  L   L + +    D  ++++++R+   +++LK
Sbjct  927  RVSLLETLLQTQKELADASQQLERLRQDMKVQKLK  961


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 54/238 (22%), Positives = 99/238 (41%), Gaps = 27/238 (11%)

Query  269   SKSELRMLLSVMEGELEARDLVIEALRELK-----WFTGI-----KTAKWENARRKEVFI  318
             S   ++++L   E E+E +   I  L+ELK        G+     +T+   + R +E+ +
Sbjct  1723  SLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV  1782

Query  319   -----QERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMS  373
                  QE   +  L +  L  Q D    A  +  +      L  L+      +  +ER+ 
Sbjct  1783  LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQE-----LEALQQEQQQAQGQEERVK  1837

Query  374   AQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVI  433
              +  A +   ++  M   +     Q+HK+ A RLEEE     + V  L    +++ G + 
Sbjct  1838  EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL----EEVLGDLR  1893

Query  434   EEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAK  491
              E+++ E  +      +++  E  +E   E R   +   Q +  L E D E E LRA+
Sbjct  1894  AESREQEKAL---LALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE  1948


>gi|13431717|sp|Q9UKX3|MYH13_HUMAN  Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) 
(MyHC-eo)
Length=1938

 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 56/280 (20%), Positives = 118/280 (42%), Gaps = 52/280 (18%)

Query  260   KKEFDVDTLSKSELRMLLSVMEGE------------LEARDLVIEALRELKWFTGIKTAK  307
             +++++ +  +K+EL+  LS    E            ++  + + EA ++L         K
Sbjct  1348  REQYEEEQEAKAELQRALSKANSEVAQWKTKYETDAIQRTEELEEAKKKLAQRLQEAEEK  1407

Query  308   WENARRKEVFIQERYGRFN--LNDPFLALQRDYEAGAG-DKEKKPVCTNPLSILEAVMAH  364
              E A  K   +++   R    + D    L+R + A A  DK+++          + V+A 
Sbjct  1408  TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN--------FDKVLAE  1459

Query  365   CKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKE  424
              K+  +   A+L AA+   + L  E  +++     ++++  +LE  R +NK     L +E
Sbjct  1460  WKQKLDESQAELEAAQKESRSLSTELFKMR---NAYEEVVDQLETLRRENKN----LQEE  1512

Query  425   CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
                L+ ++ E  + L++                      K+   + ++ ++  L E +  
Sbjct  1513  ISDLTEQIAETGKNLQEA------------------EKTKKLVEQEKSDLQVALEEVEGS  1554

Query  485   REQLRAKLNREEAHTTDLKEEIDK----MRKMIEQLKRGS  520
              E   +K+ R +   + +K E+D+      + IEQLKR S
Sbjct  1555  LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS  1594


 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 36/179 (20%), Positives = 75/179 (41%), Gaps = 8/179 (4%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEE-------E  410
             LE +    K +QE +S          K L+  +   + +EQE   L   LEE       E
Sbjct  1499  LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE  1558

Query  411   RGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM  470
               K  +V L L +   +L  KVIE+ +++E +    +   +    + +     +  +  +
Sbjct  1559  ESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRL  1618

Query  471   EAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI-DKMRKMIEQLKRGSDSKPSLSL  528
             + +ME  L+E + +      ++   + H   ++ ++ D    + + L+   D K  L++
Sbjct  1619  KKKMEGDLNEMEIQLGHSNRQMAETQRHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI  1677


 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 41/196 (20%), Positives = 96/196 (48%), Gaps = 22/196 (11%)

Query  385   KLEMEKLQLQALEQEHKKLAARLEEERGK-------NKQVVLMLVKECKQLSGKVIEEAQ  437
             KLE +   L+   ++ KKL A LE  + K       +++ ++ L  E +Q+  K+ ++  
Sbjct  1030  KLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENEKQQIEEKLKKKEF  1089

Query  438   KLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEA  497
             +L  + A++++E+  + +        +++  E++A++E+   E + E   LRAK+ ++  
Sbjct  1090  ELSQLQARIDDEQVHSLQF-------QKKIKELQARIEELEEEIEAE-HTLRAKIEKQR-  1140

Query  498   HTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTK----DRRLVSISVGTEGTVTRSVA  553
               +DL  E++++ + +E+    + ++  ++  R+ +     R L   ++  E T      
Sbjct  1141  --SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK  1198

Query  554   CQTDLVTENADHMKKL  569
              Q D V E  + +  L
Sbjct  1199  KQADSVAELGEQIDNL  1214


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 40/154 (25%), Positives = 73/154 (47%), Gaps = 26/154 (16%)

Query  380   ESRQKKLEMEKLQLQAL---EQEH--------KKLAAR---LEEERGKNKQVVLMLVKEC  425
             E + KK E E  QLQA    EQ H        K+L AR   LEEE      +   + K+ 
Sbjct  1081  EEKLKKKEFELSQLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR  1140

Query  426   KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
               L+ ++ E +++LE+                 ++   K+R  E + +M + L E   + 
Sbjct  1141  SDLARELEEISERLEEASG----------ATSAQIEMNKKREAEFQ-KMRRDLEEATLQH  1189

Query  486   EQLRAKLNREEAHT-TDLKEEIDKMRKMIEQLKR  518
             E   A L +++A +  +L E+ID ++++ ++L++
Sbjct  1190  EATAATLRKKQADSVAELGEQIDNLQRVKQKLEK  1223


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 38/182 (20%), Positives = 85/182 (46%), Gaps = 9/182 (4%)

Query  367   KMQERMSAQLAAAESRQKKLEMEKLQLQALEQE---HKKLAARLEEERGKNKQVVLMLVK  423
             ++Q R+  +   +   QKK++  + +++ LE+E      L A++E++R    + +  + +
Sbjct  1093  QLQARIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISE  1152

Query  424   ECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDT  483
               ++ SG    + +  +   A+ ++ ++   E   +  A      + +A    +L E   
Sbjct  1153  RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID  1212

Query  484   EREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVG  543
               ++++ KL +E++   +LK EID M   IE L   S SK ++    +T + +   I   
Sbjct  1213  NLQRVKQKLEKEKS---ELKMEIDDMASNIEAL---SKSKSNIERTCRTVEDQFSEIKAK  1266

Query  544   TE  545
              E
Sbjct  1267  DE  1268


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 31/175 (17%), Positives = 78/175 (44%), Gaps = 14/175 (8%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKN---  414
             LE +    ++     SAQ+   + R+ + +  +  L+    +H+  AA L +++  +   
Sbjct  1147  LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE  1206

Query  415   --------KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelS---AE  463
                     ++V   L KE  +L  ++ + A  +E +       ++    +E++ S   A+
Sbjct  1207  LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK  1266

Query  464   KRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
               + T++   +  Q +   T+  +L  ++  +E+  + L +    + + +E+LKR
Sbjct  1267  DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR  1321


>gi|13432177|sp|P35749|MYH11_HUMAN  Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC)
Length=1972

 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 32/162 (19%), Positives = 74/162 (45%), Gaps = 21/162 (12%)

Query  359   EAVMAHCKKMQERM---SAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNK  415
             + + A  KKM ++M     QL   E+ ++KL++EK+  +A  ++ +     ++++  K  
Sbjct  939   QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS  998

Query  416   QVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQME  475
             +   +L +    L+  + EE +K +++                     K +   M +++E
Sbjct  999   KERKLLEERISDLTTNLAEEEEKAKNLTKL------------------KNKHESMISELE  1040

Query  476   KQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
              +L + +  R++L     + E   +D  E+I  ++  I +LK
Sbjct  1041  VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK  1082


 Score = 40.4 bits (93),  Expect = 0.008
 Identities = 62/269 (23%), Positives = 117/269 (43%), Gaps = 27/269 (10%)

Query  270   KSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENAR--RKEVFIQERYGRF--  325
             + +L+ L    +  ++ R+  I+ LR+L+        + E+AR  R E+F   +      
Sbjct  1623  EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA  1682

Query  326   -NLNDPFLALQRDYEAGA-----GDKEKKPVC---TNPLSILEAVMAHCKKMQERMSAQL  376
              +L    + LQ D  A        D EK+ +     + LS   A+    ++++ R++   
Sbjct  1683  KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE  1742

Query  377   AAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG---KNKQVVLMLVKECKQLSGKVI  433
                E  Q  +E    +++   Q+ ++L+  L  ER    KN+     L ++ K+L  K+ 
Sbjct  1743  EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH  1802

Query  434   EEA----QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLR  489
             E       K +  +A LE +  +  E  E+ + EK+ +T+   Q +K+L E   + E   
Sbjct  1803  EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED--  1860

Query  490   AKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
                  E       KE+ +K    ++QLKR
Sbjct  1861  -----ERKMAEQYKEQAEKGNARVKQLKR  1884


 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 37/168 (22%), Positives = 79/168 (47%), Gaps = 26/168 (15%)

Query  392   QLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekk  451
             ++QA E E +K   R  +++ +N+      +KE +Q   ++ EE   L++ +    E   
Sbjct  853   EMQAKEDELQKTKER--QQKAENE------LKELEQKHSQLTEEKNLLQEQLQAETELYA  904

Query  452   ktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEID----  507
             +  E+   L+A+K+   E+  +ME +L E +   +QL+A+  +      DL+E+++    
Sbjct  905   EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA  964

Query  508   --------------KMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSIS  541
                           K++K+ +++    D    LS  RK  + R+  ++
Sbjct  965   ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT  1012


 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 71/310 (22%), Positives = 137/310 (44%), Gaps = 76/310 (24%)

Query  262   EFDVDTLSKSELRMLLSVMEGELEA--RDLVIEALRELKWFT-GIKTAKWENARRKEVFI  318
             E++ +   + + R L +  + +LE   +DL ++A   +K     IK  +   A+ K+   
Sbjct  1600  EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR  1659

Query  319   QERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAA  378
             +    R + ++ F        A A + EKK          +++ A   ++QE     LAA
Sbjct  1660  ELEDARASRDEIF--------ATAKENEKKA---------KSLEADLMQLQE----DLAA  1698

Query  379   AESRQKKLEMEKLQL-----------QALEQEHKKLAAR-------LEEERGKNKQVVLM  420
             AE  +K+ ++EK +L            AL+ E ++L AR       LEEE+G N + +  
Sbjct  1699  AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG-NMEAMSD  1757

Query  421   LVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSE  480
              V+       K  ++A++L + +A                     RST  + +  +Q  +
Sbjct  1758  RVR-------KATQQAEQLSNELAT-------------------ERSTAQKNESARQ--Q  1789

Query  481   FDTEREQLRAKLNREE-AHTTDLKEEID----KMRKMIEQLKRGSDSKPSLSLPRKTKDR  535
              + + ++LR+KL+  E A  +  K  I     K+ ++ EQ+++ +  K + +   K KD+
Sbjct  1790  LERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK  1849

Query  536   RLVSISVGTE  545
             +L  I +  E
Sbjct  1850  KLKEILLQVE  1859


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 50/189 (26%), Positives = 85/189 (44%), Gaps = 25/189 (13%)

Query  346   EKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKL----QLQALEQEHK  401
             E+K +    L  LE  +   +  ++++  +   AE++ KKLE E L    Q   L +E K
Sbjct  944   ERKKMAQQMLD-LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK  1002

Query  402   KLAARL---------EEERGKN----KQVVLMLVKECKQLSGKVIEEAQKLEDVMAklee  448
              L  R+         EEE+ KN    K     ++ E +    K  +  Q+LE +  KLE 
Sbjct  1003  LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG  1062

Query  449   ekkktneleeelSAE----KRRSTEMEAQMEKQLSEFDTEREQLR---AKLNREEAHTTD  501
             +    +E   +L A+    K +  + E +++  L+  D E  Q      K+   E H +D
Sbjct  1063  DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD  1122

Query  502   LKEEIDKMR  510
             L+E++D  R
Sbjct  1123  LQEDLDSER  1131


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 50/207 (24%), Positives = 86/207 (41%), Gaps = 41/207 (19%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQE------HKKLAARLEE----------  409
             K   ER  A+  A E   K L + +   +ALE +      +K L A +E+          
Sbjct  1466  KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK  1525

Query  410   ---ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDV-MAkleeekkktneleeelSAEKR  465
                E  K+K+ +   ++E K    ++ +E Q  ED  +      +    + E +L A   
Sbjct  1526  NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE  1585

Query  466   RSTEMEAQMEKQLSEFDTEREQLR-------AKLNREEAHTTDL-----------KEEID  507
             ++ E   Q+++QL E++TE E  R       A   + E    DL           +E I 
Sbjct  1586  QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK  1645

Query  508   KMRKMIEQLKRGSDSKPSLSLPRKTKD  534
             ++RK+  Q+K   D +  L   R ++D
Sbjct  1646  QLRKLQAQMK---DFQRELEDARASRD  1669


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 46/178 (25%), Positives = 75/178 (42%), Gaps = 8/178 (4%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALE-QEHKKLAARLEEERGKNKQ  416
             LE  M   K   E +  +L A E  + +LE   + +QAL+ Q  + L AR E+   K +Q
Sbjct  1537  LETQMEEMKTQLEELEDELQATEDAKLRLE---VNMQALKGQFERDLQARDEQNEEKRRQ  1593

Query  417   VVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEK  476
             +   L +   +L     E  Q+     AK + E    +   +  SA K R   ++   + 
Sbjct  1594  LQRQLHEYETELED---ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL  1650

Query  477   QLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
             Q    D +RE   A+ +R+E   T  KE   K + +   L +  +   +    RK  D
Sbjct  1651  QAQMKDFQRELEDARASRDEIFAT-AKENEKKAKSLEADLMQLQEDLAAAERARKQAD  1707


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 29/143 (20%), Positives = 64/143 (44%), Gaps = 3/143 (2%)

Query  380   ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQ--  437
             E ++KKLE +  +LQ+   + ++  A L ++  K +  V  +     +  GK I+ A+  
Sbjct  1251  EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV  1310

Query  438   -KLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREE  496
               L   +   +E  ++    +  +S + R+  E    ++ QL E    ++ L   ++   
Sbjct  1311  ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN  1370

Query  497   AHTTDLKEEIDKMRKMIEQLKRG  519
                +D K+++      +E L+ G
Sbjct  1371  IQLSDSKKKLQDFASTVEALEEG  1393


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 38/177 (21%), Positives = 82/177 (46%), Gaps = 27/177 (15%)

Query  344   DKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKL  403
             + E K      +S L   ++  KK  +  ++ + A E  +K+ + E   ++ L Q++++ 
Sbjct  1355  EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE---IENLTQQYEEK  1411

Query  404   AA---RLEEERGKNKQVVLMLVKEC---KQLSGKVIEEAQKLEDVMAkleeekkktnele  457
             AA   +LE+ + + +Q +  LV +    +QL   + ++ +K + ++A+ +    K     
Sbjct  1412  AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY----  1467

Query  458   eelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
                 A++R   E EA+          E+E     L R      + KEE+++  KM++
Sbjct  1468  ----ADERDRAEAEAR----------EKETKALSLARALEEALEAKEELERTNKMLK  1510


>gi|62901456|sp|Q8NET8|TRPV3_HUMAN  Transient receptor potential cation channel subfamily V member 
3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)
Length=790

 Score = 40.8 bits (94),  Expect = 0.006
 Identities = 46/170 (27%), Positives = 68/170 (40%), Gaps = 30/170 (17%)

Query  972   LLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGF------  1025
             +L   +N E  +  Y   +G +AL  A +    D   LL++A A VNA  K  F      
Sbjct  199   ILGRFINAEYTEEAY---EGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQ  255

Query  1026  --------TPLCAAAAQGHFECVELLISYD-ANINHAADGGQTPLYLAC------KNGN-  1069
                     TPL  AA     E V+LL+ ++  +I      G   L+         K  N 
Sbjct  256   HEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQND  315

Query  1070  --KECIKLLLEAGTNRSVKTT---DGWTPVHAAVDTGNVDSLKLLMYHRI  1114
               K    ++L    N  ++TT   DG TP+  A   G  + LK ++   I
Sbjct  316   FVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREI  365


>gi|10720353|sp|O15078|CE290_HUMAN  Centrosomal protein Cep290
Length=1539

 Score = 40.4 bits (93),  Expect = 0.008
 Identities = 35/163 (21%), Positives = 72/163 (44%), Gaps = 25/163 (15%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQA---LEQEHKKLAARLEEERGKN-KQVVLML  421
            + + ER+ +QLA  E +QK L    L+L+A      E + ++A  ++E   N +Q+V   
Sbjct  784  RNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRH  843

Query  422  VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEF  481
             +E K     + E   KL++ +                     + S   E  +   L++ 
Sbjct  844  TRELKTQVEDLNENLLKLKEAL---------------------KTSKNRENSLTDNLNDL  882

Query  482  DTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKP  524
            + E ++ +   N+      ++ +E D++++ I++L  G   KP
Sbjct  883  NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP  925


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 44/205 (21%), Positives = 89/205 (43%), Gaps = 18/205 (8%)

Query  334   LQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQL  393
             L+R  +      + KP+  N  S++E +    KK++ ++  ++   + +  K +  K +L
Sbjct  910   LKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEEL  969

Query  394   QALEQEHKKLAARLEEERGKNKQ---VVLMLVKE---CKQLSGKVIEEAQKLEDVMAkle  447
                E E KK  A++E  R K K+    V  L K+    K L  K  +E   L+  +    
Sbjct  970   IRWE-EGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTG  1028

Query  448   eekkktneleeelSAE-----KRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDL  502
                 +   +    S +     K+R+ ++E  +    +     R+ +   L+ +  +   L
Sbjct  1029  MTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRY---L  1085

Query  503   KEEIDKMRKMIEQLKRGSDSKPSLS  527
             +E++  + K   Q  + + SKPS+S
Sbjct  1086  QEKLHALEK---QFSKDTYSKPSIS  1107


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 46/189 (24%), Positives = 89/189 (47%), Gaps = 28/189 (14%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQA-LEQEHKKLAARLEEERGKNKQ  416
            L +++   KK+ + +  Q    E + K+ E  KLQLQ   E E KK+ A +E+     K 
Sbjct  697  LSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVED----LKY  752

Query  417  VVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRS---------  467
            ++    KE + L  ++  +AQK  +  A     +     L+ +L+ ++++          
Sbjct  753  LLDQSQKESQCLKSEL--QAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLE  810

Query  468  --TEMEAQMEKQLSEFDTEREQLRAKLNRE---EAHTTDLKEEIDKMR----KMIEQLKR  518
               EM A  E+++    +++E   A LN +   + HT +LK +++ +     K+ E LK 
Sbjct  811  LRAEMTAAAEERIISATSQKE---AHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKT  867

Query  519  GSDSKPSLS  527
              + + SL+
Sbjct  868  SKNRENSLT  876


>gi|1705730|sp|P55273|CDN2D_HUMAN  Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Length=166

 Score = 40.4 bits (93),  Expect = 0.008
 Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 2/83 (2%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA  1020
             +  AA  G +  L +L+ E G D+N     G   ++ A + GHT  V   L+AE+ ++  
Sbjct  78    VHDAARTGFLDTLKVLV-EHGADVNVPDGTGALPIHLAVQEGHTAVVS-FLAAESDLHRR  135

Query  1021  DKNGFTPLCAAAAQGHFECVELL  1043
             D  G TPL  A  +G  + V++L
Sbjct  136   DARGLTPLELALQRGAQDLVDIL  158


 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 7/98 (7%)

Query  1016  QVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADG-GQTPLYLACKNGNKECIK  1074
             +V A D+     L  AAA+G  + V  L+  +     A +  G+T L +         ++
Sbjct  5     EVRAGDR-----LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALE  59

Query  1075  LLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYH  1112
             LL + G + +V+ T G +PVH A  TG +D+LK+L+ H
Sbjct  60    LLKQ-GASPNVQDTSGTSPVHDAARTGFLDTLKVLVEH  96


>gi|50400544|sp|Q8IZ07|ANR13_HUMAN  Ankyrin repeat domain-containing protein 13 (KE03 protein)
Length=590

 Score = 40.4 bits (93),  Expect = 0.008
 Identities = 20/65 (30%), Positives = 35/65 (53%), Gaps = 0/65 (0%)

Query  1049  NINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKL  1108
             N+      G+T L+LA   G+ E  ++LL    + + +   GWT +H AV TG+ + +  
Sbjct  33    NVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYT  92

Query  1109  LMYHR  1113
             ++ HR
Sbjct  93    VLQHR  97


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 17/56 (30%), Positives = 29/56 (51%), Gaps = 0/56 (0%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISY  1046
             G + L+ A   GH +  R+LL  +A V   ++ G+T L  A + G  E V  ++ +
Sbjct  41    GRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQH  96


>gi|20139283|sp|Q9UL16|CCD19_HUMAN  Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium-specific 
protein 1)
Length=386

 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 38/154 (24%), Positives = 78/154 (50%), Gaps = 6/154 (3%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
            ++M++    +   AE R+++ E     ++ L++E  K   R ++++ K +  +  +  E 
Sbjct  125  EQMEKNQEERSLLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDEN  184

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEK-RRSTEMEAQ----MEKQLSE  480
            ++   +++ + +KL D M     +KK   E E E   E+ RR  E E      M+++  +
Sbjct  185  QKQKAELLAQ-EKLADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQD  243

Query  481  FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
            +  E++ LRAK N+E A     ++E +  RK +E
Sbjct  244  YQAEQDALRAKRNQEVADREWRRKEKENARKKME  277


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 38/185 (20%), Positives = 76/185 (41%), Gaps = 40/185 (21%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKL----EMEKLQLQALEQEHKKLAARLEEERGK  413
            ++AVM   K M+++         +  KKL    E+ K + Q L Q   KL  R+E+E   
Sbjct  1    MDAVMTRKKIMKQKEMVW-----NNNKKLSDLEEVAKERAQNLLQRANKL--RMEQEEEL  53

Query  414  NKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ  473
                 ++L  +C  +    I E Q+++  +                 + EKR    ME +
Sbjct  54   KDMSKIILNAKCHAIRDAQILEKQQIQKEL----------------DTEEKRLDQMMEVE  97

Query  474  MEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTK  533
             +K +               +EE      +E I   R+++EQ+++  + +  L+  R+ +
Sbjct  98   RQKSIQR-------------QEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQE  144

Query  534  DRRLV  538
              +++
Sbjct  145  KEQML  149


>gi|14548073|sp|O00221|IKBE_HUMAN  NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) 
(IkappaBepsilon) (IKB-epsilon) (IKBE)
Length=361

 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 30/76 (39%), Positives = 39/76 (51%), Gaps = 2/76 (2%)

Query  961   LQQAAAQGNVTLLSMLLNEEGLDINYS-CEDGHSALYSAAKNGHTDCVRLLLSAEAQVNA  1019
             L  A  Q N  L+ +LL   G DI+      G +AL+ A +      V+ LL A AQV+A
Sbjct  235   LHIATLQKNQPLMELLLRN-GADIDVQEGSSGKTALHLAVETQERGLVQFLLQAGAQVDA  293

Query  1020  ADKNGFTPLCAAAAQG  1035
                NG TPL  AA +G
Sbjct  294   RMLNGCTPLHLAAGRG  309


 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 1/79 (1%)

Query  1024  GFTPLCAAAAQGHFECVELLISYDANIN-HAADGGQTPLYLACKNGNKECIKLLLEAGTN  1082
             G   L  A  Q +   +ELL+   A+I+      G+T L+LA +   +  ++ LL+AG  
Sbjct  231   GLACLHIATLQKNQPLMELLLRNGADIDVQEGSSGKTALHLAVETQERGLVQFLLQAGAQ  290

Query  1083  RSVKTTDGWTPVHAAVDTG  1101
                +  +G TP+H A   G
Sbjct  291   VDARMLNGCTPLHLAAGRG  309


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 1/113 (0%)

Query  982   LDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAAD-KNGFTPLCAAAAQGHFECV  1040
             LD+      G + L+ A    +   + LLL   A ++  +  +G T L  A        V
Sbjct  222   LDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGSSGKTALHLAVETQERGLV  281

Query  1041  ELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTP  1093
             + L+   A ++     G TPL+LA   G       L +AG +  ++  +  TP
Sbjct  282   QFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP  334


>gi|14195005|sp|O60437|PEPL_HUMAN  Periplakin (195 kDa cornified envelope precursor protein) (190 
kDa paraneoplastic pemphigus antigen)
Length=1756

 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 43/158 (27%), Positives = 85/158 (53%), Gaps = 15/158 (9%)

Query  366   KKMQERMSA-QLAAAESRQKKLEMEKLQLQALEQ---EHKKLAARLEEERGKNKQVVLML  421
             +++Q+R++A +   AE+R+K    +K+ LQ   Q   EH  L  +LEEE+ + +    +L
Sbjct  1421  QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQ----LL  1476

Query  422   VKECKQLSGKV--IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLS  479
               E + L  K+  +E+A+  E V+     + +K +  +E    +   S E E++ +++L 
Sbjct  1477  EGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKS--SLEEESRSKREL-  1533

Query  480   EFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
               D E  +L A+L+  E H +   +E+D +R+   +L+
Sbjct  1534  --DVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQ  1569


 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 45/161 (27%), Positives = 82/161 (50%), Gaps = 14/161 (8%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHK--------KLAARLEEERGKNKQV  417
             +++Q  ++ +    +  Q++LE  +LQL+ALEQE +        K   R+E +R +  + 
Sbjct  951   QQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADE-  1009

Query  418   VLMLVKECKQL-SGKVIEEAQKL---EDVMAkleeekkktneleeelSAEKRRSTEMEAQ  473
             VL L +E + L   K   EA+ L   + V A  EE+ +   ++ E+   + +   ++EA+
Sbjct  1010  VLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAE  1069

Query  474   MEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
              + QL E    ++QLR K   E +   D  + ++K R M E
Sbjct  1070  YQ-QLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAE  1109


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 45/218 (20%), Positives = 92/218 (42%), Gaps = 24/218 (11%)

Query  380   ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVI------  433
             E  Q K E+  L+ +  E++ K++   LE ER   ++ +    +E  ++  +V+      
Sbjct  1300  EDPQTKEEVASLRAKLSEEQKKQVD--LERERASQEEQIARKEEELSRVKERVVQQEVVR  1357

Query  434   -EEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER-------  485
              EE   L    +   E         ++L AE RR      ++E+QL E + ER       
Sbjct  1358  YEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAE  1417

Query  486   ---EQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISV  542
                ++L+ +L   E    + +E++   +K++ Q       + +L   +  +++    +  
Sbjct  1418  REVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLE  1477

Query  543   GTEGTVTRSVACQTDLVTENADHMKKLPLTMPVKPSTG  580
             G   T+ R +A       E A+  +K+ L+  V+   G
Sbjct  1478  GELETLRRKLA-----ALEKAEVKEKVVLSESVQVEKG  1510


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 31/114 (27%), Positives = 49/114 (42%), Gaps = 2/114 (1%)

Query  329   DPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCK-KMQERMSAQLAAAESRQKKLE  387
             D  L L+ + EA    K  +      L    A +A  K + QE+++ +         +LE
Sbjct  1008  DEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLE  1067

Query  388   MEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKV-IEEAQKLE  440
              E  QLQ   Q   +L  + EEE    +  +  L KE     GK+ ++E  K+E
Sbjct  1068  AEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVE  1121


>gi|27923755|sp|Q9P2M7|CING_HUMAN  Cingulin
Length=1197

 Score = 40.0 bits (92),  Expect = 0.010
 Identities = 39/170 (22%), Positives = 75/170 (44%), Gaps = 15/170 (8%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQL-------QALEQEHKKLAARLEEE  410
            LE     C ++QE +  +   A+   K+L+  K  L         LE +  +L  +L+  
Sbjct  390  LEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHV  449

Query  411  RGKN--KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRST  468
            +G    K+V+L  + E ++L  +V+E  Q++E+ +      + +  EL     A K    
Sbjct  450  QGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQL------RLRERELTALKGALKEEVA  503

Query  469  EMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
              + ++E    ++  + EQLR  +         L+ E  KM  ++  L+R
Sbjct  504  SRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQR  553


 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 57/277 (20%), Positives = 112/277 (40%), Gaps = 44/277 (15%)

Query  278  SVMEGELEARDLVIEALRELKWFTGIKTAKWENARRK-------------EVFIQERYGR  324
            +V+E E +    ++  L+     T  +T  W++  +K             ++ +++    
Sbjct  535  AVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEME  594

Query  325  FNLNDPFLALQRDYE---AGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAES  381
              L +    LQR+ E   A AGD  +  V    L   +  +   K++Q    +Q  A   
Sbjct  595  EELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEEL---KELQAERQSQEVAGRH  651

Query  382  RQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS-GKVIEEAQKLE  440
            R ++LE    QL  L  E  +    LEE+  + ++ +  L ++C++ S  K++ EA+   
Sbjct  652  RDRELEK---QLAVLRVEADR-GRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEAT-  706

Query  441  DVMAkleeekkktneleeelSAEKRR------------------STEMEAQMEKQLSEFD  482
             V+ +     + T    +E + E RR                     +EA++  +L   +
Sbjct  707  -VLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLE  765

Query  483  TEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRG  519
             E++QL   LN  +     L      +   +E+ +RG
Sbjct  766  AEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRG  802


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 38/157 (24%), Positives = 77/157 (49%), Gaps = 13/157 (8%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVV---LMLVKEC  425
            QE   +  AA  + + +LE  +  L  L QE + L   LEEE GK ++V+      ++E 
Sbjct  779  QEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE-GKQREVLRRGKAELEEQ  837

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
            K+L  + ++   K  + + +  ++  +  + + E   EK R    +AQ  +Q  ++ +E 
Sbjct  838  KRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQ--RQAKDWASEA  895

Query  486  EQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS  522
            E+    L+R       L++EI ++R+ ++  +   D+
Sbjct  896  EKTSGGLSR-------LQDEIQRLRQALQASQAERDT  925


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 35/181 (19%), Positives = 84/181 (46%), Gaps = 16/181 (8%)

Query  368   MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVK---E  424
             + +R+      AE++++  +    QL+ LE++  +L   L+EE+   + +   + +   +
Sbjct  933   LAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQ  992

Query  425   CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
               QL  ++++E    +D+       +++  +L       +  S+E   +    LS+ +++
Sbjct  993   VDQLRTELMQERSARQDLECDKISLERQNKDL-----KTRLASSEGFQKPSASLSQLESQ  1047

Query  485   REQLRAKLNREEAHTTDLKEEIDKMRKMIEQL--------KRGSDSKPSLSLPRKTKDRR  536
              + L+ +L  EE   T L+    K+ + +++L        +  +D K  LSL  K   R+
Sbjct  1048  NQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQ  1107

Query  537   L  537
             +
Sbjct  1108  V  1108


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 32/176 (18%), Positives = 80/176 (45%), Gaps = 22/176 (12%)

Query  344   DKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKL  403
             D+EK     N + +L   +   +   +++  +L    S ++ LE +K+   +LE+++K L
Sbjct  973   DEEK-----NTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKI---SLERQNKDL  1024

Query  404   AARLEEERGKNK-QVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSA  462
               RL    G  K    L  ++   QL  + ++  ++ + V+     +             
Sbjct  1025  KTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKL------------  1072

Query  463   EKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
              +R+  E+  Q+E +    + +++QL  ++   +    + +EEI+++  + ++ +R
Sbjct  1073  -ERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQR  1127


>gi|13638390|sp|P12882|MYH1_HUMAN  Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin 
heavy chain IIx/d) (MyHC-IIx/d)
Length=1939

 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 42/208 (20%), Positives = 94/208 (45%), Gaps = 16/208 (7%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAAR---LEEERGKNKQVVLMLV  422
             +++ E++  +       Q K+E E+     L+++ K+L AR   LEEE    +       
Sbjct  1078  QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE  1137

Query  423   KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFD  482
             K+   LS ++ E +++LE+                 ++   K+R  E + +M + L E  
Sbjct  1138  KQRSDLSRELEEISERLEEA----------GGATSAQIEMNKKREAEFQ-KMRRDLEEAT  1186

Query  483   TEREQLRAKLNREEAHT-TDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSIS  541
              + E   A L ++ A +  +L E+ID ++++ ++L++   S+  + +     +   VS +
Sbjct  1187  LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK-EKSEMKMEIDDLASNMETVSKA  1245

Query  542   VGTEGTVTRSVACQTDLVTENADHMKKL  569
              G    + R++  Q   +    +  ++L
Sbjct  1246  KGNLEKMCRALEDQLSEIKTKEEEQQRL  1273


 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 43/197 (21%), Positives = 83/197 (42%), Gaps = 15/197 (7%)

Query  334   LQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQ  392
             L+ + EA    + K     + LS  LE +    ++     SAQ+   + R+ + +  +  
Sbjct  1122  LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD  1181

Query  393   LQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkk  452
             L+    +H+  AA L ++   +       V E  +    +    QKLE   ++++ E   
Sbjct  1182  LEEATLQHEATAATLRKKHADS-------VAELGEQIDNLQRVKQKLEKEKSEMKMEIDD  1234

Query  453   tneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQ-------LRAKLNREEAHTTDLKEE  505
                  E +S  K    +M   +E QLSE  T+ E+       L A+  R +  + +   +
Sbjct  1235  LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ  1294

Query  506   IDKMRKMIEQLKRGSDS  522
             +D+   ++ QL RG  +
Sbjct  1295  LDEKDTLVSQLSRGKQA  1311


 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 66/337 (19%), Positives = 130/337 (38%), Gaps = 72/337 (21%)

Query  339   EAGAGDKEKKPVCTNPLSI----------LEAVMAHCKKMQERMSAQLAA-AESRQKKLE  387
             E  A  KE + + T    I          LE +    K +Q+ +S      AE  ++  E
Sbjct  1470  ELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE  1529

Query  388   MEKLQLQALEQEHKKLAARLEE-------ERGKNKQVVLMLVKECKQLSGKVIEEAQKLE  440
             +EK++ Q +EQE  +L A LEE       E GK  ++ L L +   ++  K+ E+ ++++
Sbjct  1530  LEKIKKQ-VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID  1588

Query  441   DVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE----------------  484
              +        +      +     +  +  ++ +ME  L+E + +                
Sbjct  1589  QMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR  1648

Query  485   -------------------REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGS-----  520
                                +E L+ +L   E     L+ EI+++R  +EQ +R       
Sbjct  1649  NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ  1708

Query  521   ---DSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTE--NADHMKKLPLTMPV  575
                D+   + L   T++  L++     E  +++      D++ E  NA+   K       
Sbjct  1709  ELLDASERVQL-LHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAK-------  1760

Query  576   KPSTGSPLVSANAKGSVCTSATMARPGIDRQASYGDL  612
             K  T + +++   K    TSA + R   + + +  DL
Sbjct  1761  KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL  1797


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 30/131 (22%), Positives = 65/131 (49%), Gaps = 6/131 (4%)

Query  399  EHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnelee  458
            E +K  A ++EE  K K+ +     + K+L  K++   Q+  D+  +++ E     + EE
Sbjct  848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE  907

Query  459  elSAEKRRSTEMEAQMEKQLSEFDTERE---QLRAKLNREEAHTTDLKEEIDKMR---KM  512
                  +   ++EA++++     + E E   +L AK  + E   ++LK++ID +      
Sbjct  908  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK  967

Query  513  IEQLKRGSDSK  523
            +E+ K  +++K
Sbjct  968  VEKEKHATENK  978


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 41/165 (24%), Positives = 74/165 (44%), Gaps = 10/165 (6%)

Query  376   LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL---MLVKECKQLSGKV  432
             LA AE R  +L   K+QL+A   + K++  R E+E   N ++      L  EC +L    
Sbjct  902   LADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEINAELTAKKRKLEDECSELK---  955

Query  433   IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKL  492
              ++   LE  +AK+E+EK  T    + L+ E     E  A++ K+        +Q    L
Sbjct  956   -KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL  1014

Query  493   NREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
               EE     L +   K+ + ++ L+   + +  + +  +   R+L
Sbjct  1015  QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL  1059


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 55/251 (21%), Positives = 110/251 (43%), Gaps = 24/251 (9%)

Query  303   IKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVM  362
             IKT     A+ KEV  +       +N    A +R  E    + +K       +  LE  +
Sbjct  913   IKTKIQLEAKIKEV-TERAEDEEEINAELTAKKRKLEDECSELKKD------IDDLELTL  965

Query  363   AHCKKMQ-------ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNK  415
             A  +K +       + ++ ++A  +    KL  EK   +AL++ H++    L+ E  K  
Sbjct  966   AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK---KALQEAHQQTLDDLQAEEDKVN  1022

Query  416   QVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ-M  474
              +    +K  +Q+    +E + + E  +    E  K+  E + +L+ E     E + Q +
Sbjct  1023  TLTKAKIKLEQQVDD--LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESAMDIENDKQQL  1080

Query  475   EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD----SKPSLSLPR  530
             +++L + + E   L++K+  E+A    L+++I +++  IE+L+   +    S+      R
Sbjct  1081  DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR  1140

Query  531   KTKDRRLVSIS  541
                 R L  IS
Sbjct  1141  SDLSRELEEIS  1151


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 57/315 (18%), Positives = 124/315 (39%), Gaps = 40/315 (12%)

Query  255   IIISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRK  314
             I+ S +   D +  S+++   L   MEG+L   ++      +L     +      N R  
Sbjct  1597  IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI------QLNHANRMAAEALRNYRNT  1650

Query  315   EVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSA  374
             +  +++   + +L+D   + +   E  A  + +  +    +  L A +   ++ ++    
Sbjct  1651  QAILKDT--QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ  1708

Query  375   QLAAAESR--------------QKKLEMEKLQLQA-----------LEQEHKKL---AAR  406
             +L  A  R              +KKLE +  Q+Q             E++ KK    AA 
Sbjct  1709  ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM  1768

Query  407   LEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDV--MAkleeekkktneleeelSAEK  464
             + EE  K +     L +  K L   V +   +L++   +A    +K+           E 
Sbjct  1769  MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEG  1828

Query  465   RRSTEMEAQME--KQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS  522
                +E +  +E  K L + + + ++L  +   +  +   L++ +DK++  ++  KR ++ 
Sbjct  1829  EVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE  1888

Query  523   KPSLSLPRKTKDRRL  537
                 S    +K RR+
Sbjct  1889  AEEQSNVNLSKFRRI  1903


>gi|266902|sp|P30622|REST_HUMAN  Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg 
intermediate filament associated protein) (Cytoplasmic 
linker protein 1)
Length=1427

 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 85/417 (20%), Positives = 171/417 (41%), Gaps = 61/417 (14%)

Query  211   LRRLNVVPLTTFKQIKEIGKEPAPAVREASPSWRSVVRWPTPSMIIISRKKEFDVDTLSK  270
             L  ++ V  T  K+++ + ++ A A  EA    RS+         +  ++++F++ +   
Sbjct  828   LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK---LHQKEEQFNMLSSDL  884

Query  271   SELRMLLSVMEGE-----------LEARDLVIEALRELKWFTGIKTAKW----ENARRKE  315
              +LR  L+ ME +           ++A++ +   + E+   +G  +++     +  R KE
Sbjct  885   EKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE  944

Query  316   VFIQE---RYGRFNLNDPFL----------ALQRDYEAGAGDKEKKPVCTNPLSILEAVM  362
               ++E   +  + N N  FL          A Q   EA    +E+K      LS LE  M
Sbjct  945   RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM  1004

Query  363   AHCKKMQERMSAQLAAAESRQKKLEMEKLQ------------LQALEQEHKKLAARLEE-  409
                    + + A+   A S  K    E LQ            L+   +E+  L   LEE 
Sbjct  1005  ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL  1064

Query  410   ----ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVM---AkleeekkktneleeelSA  462
                 ++ K  Q     ++  +Q++ +  E    LED     AKL+ E     E   +   
Sbjct  1065  RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE  1124

Query  463   EKRRSTEMEAQMEKQLSEFDTEREQLR-------AKLNREEAHTTDLKEEIDKMRKMIEQ  515
             E  +S E+     +++ EF  E E L+        +L+  +     L EE+ + R  +  
Sbjct  1125  ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTS  1184

Query  516   LKRGSDSKPSLS---LPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKL  569
              ++  + +  L+   L  K ++ + +  +   + ++ +S++  + L+TE    ++KL
Sbjct  1185  HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL  1241


 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 53/230 (23%), Positives = 91/230 (39%), Gaps = 16/230 (6%)

Query  355  LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQ--------LQALEQEHKKLAAR  406
            L  L    +  K   +++  QL AAE + K LE+EK           + L+    KL   
Sbjct  765  LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKL-TN  823

Query  407  LEEERGKNKQVVLMLVKECKQLSGK---VIEEAQKLEDVMAkleeekkktneleeelSAE  463
            L+E   +  QV   L KE + L  K     EEA  ++  M +   +  +  E    LS++
Sbjct  824  LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD  883

Query  464  KRRSTEMEAQMEKQLSEFDTEREQL---RAKLNREEAHTTDLK-EEIDKMRKMIEQLKRG  519
              +  E  A ME +  E D   EQL   + KL  + A    +  +   ++ KM ++L+  
Sbjct  884  LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK  943

Query  520  SDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKL  569
                  L L     +     +    E    ++   Q +   ++ +  K+L
Sbjct  944  ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL  993


 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 38/169 (22%), Positives = 79/169 (46%), Gaps = 11/169 (6%)

Query  363  AHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNK-QVVLML  421
            AH K+M+   +  +   + ++  LE  + +L   E +H      +E E   NK Q   + 
Sbjct  676  AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH-----LVEMEDTLNKLQEAEIK  730

Query  422  VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEF  481
            VKE + L  K  E+ + +++  ++L+  ++K  +L+    A     +EM+ ++ +QL   
Sbjct  731  VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK-KLRQQLEAA  789

Query  482  DTEREQLRAKLNREEAHTTDLKEEID----KMRKMIEQLKRGSDSKPSL  526
            + + + L  + N E +  + +  E+     K+  + E L   S  K +L
Sbjct  790  EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETL  838


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 34/165 (20%), Positives = 74/165 (44%), Gaps = 16/165 (9%)

Query  377  AAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEA  436
            A  E+ QK+++      + L +E++ L ++LE    +N  V+ +      +L   +    
Sbjct  568  AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK---SKLETAIASHQ  624

Query  437  QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREE  496
            Q +E++               + L  E     E++ Q+EK   ++  E E L+ + + E 
Sbjct  625  QAMEELKV----------SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER  674

Query  497  -AHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSI  540
             AH  +++    K+ K+I++ +   ++    S   K +D+ LV +
Sbjct  675  AAHAKEMEALRAKLMKVIKEKENSLEA--IRSKLDKAEDQHLVEM  717


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 43/175 (24%), Positives = 80/175 (45%), Gaps = 8/175 (4%)

Query  352   TNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEER  411
             T  L+ LE       K+Q  +       E+  K +E      + L  E++K+    EE R
Sbjct  1092  TETLASLEDTKQTNAKLQNELDT---LKENNLKNVEELNKSKELLTVENQKM----EEFR  1144

Query  412   GKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME  471
              + + +     ++ +QLS  + EE  KL + + +  +E     +LEEE S    +  EM+
Sbjct  1145  KEIETLKQAAAQKSQQLSA-LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK  1203

Query  472   AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSL  526
              +  K + + D E+  L+  ++   A  T+   E++K+R  +  L+  + S  SL
Sbjct  1204  KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL  1258


>gi|14194461|sp|Q99996|AKAP9_HUMAN  A-kinase anchor protein 9 (Protein kinase A-anchoring protein 
9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase 
anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 
120-like protein) (Hyperion protein) (Yotiao protein) (Centrosome- 
and Golgi-localized PKN-associated protein) (CG-NAP)
Length=3911

 Score = 39.7 bits (91),  Expect = 0.013
 Identities = 31/149 (20%), Positives = 73/149 (48%), Gaps = 26/149 (17%)

Query  370   ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS  429
             +R+  +L  A +R ++LE E+ Q+Q   +E + L+ + E  + +   V   L++E ++L 
Sbjct  1958  DRLEQELLCASNRLQELEAEQQQIQ---EERELLSRQKEAMKAEAGPVEQQLLQETEKLM  2014

Query  430   GKVIE---EAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTERE  486
              + +E   +A+K+ D +                    +++   +E  +E+Q+S F    +
Sbjct  2015  KEKLEVQCQAEKVRDDL--------------------QKQVKALEIDVEEQVSRFIELEQ  2054

Query  487   QLRAKLNREEAHTTDLKEEIDKMRKMIEQ  515
             +   +L         L+++++KMRK +++
Sbjct  2055  EKNTELMDLRQQNQALEKQLEKMRKFLDE  2083


 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 56/252 (22%), Positives = 107/252 (42%), Gaps = 40/252 (15%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQ-ALEQEHKKL----AARLE----  408
             L ++     ++QE++S++       + +L   KL+L+  L+ +HK L    A RLE    
Sbjct  3144  LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK  3203

Query  409   ------------EERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnel  456
                          E+ K++++   L KE  +L      + ++LED+   LE +K++  +L
Sbjct  3204  TDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL  3263

Query  457   eeelSAEKRRSTEMEAQMEK-------QLSEFDTEREQLRAKLNREEAHTTDLKEEIDKM  509
                L  +K+   E + ++E        QLSE      +L+  L  E+    ++   +D+ 
Sbjct  3264  NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE  3323

Query  510   RKMIEQLKRG---SDSKP---------SLSLPRKTKDRRLVSISVGTEGTVTRSVACQTD  557
             R++  QL+       S+P          L    + K  R+V +   TE     S+  +  
Sbjct  3324  RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQ  3383

Query  558   LVTENADHMKKL  569
             +  +   H K L
Sbjct  3384  MEKDRQVHRKTL  3395


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 36/184 (19%), Positives = 84/184 (45%), Gaps = 10/184 (5%)

Query  334  LQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQL  393
            LQ+  E  A  K++  + T     L A +   ++ ++    +      + +KL+++  QL
Sbjct  202  LQQLQEFEAAIKQRDGIITQ----LTANLQQARREKDETMREFLELTEQSQKLQIQFQQL  257

Query  394  QALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkkt  453
            QA E       +    +  + KQ +L   ++ ++    + +  +K ED   ++   ++K 
Sbjct  258  QASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKI  317

Query  454  neleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMI  513
                     E  +  ++E   ++++ E +T  E+L  K+  EE  T +LK+++    K++
Sbjct  318  KVY------EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL  371

Query  514  EQLK  517
             +L+
Sbjct  372  GELQ  375


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 49/260 (18%), Positives = 111/260 (42%), Gaps = 29/260 (11%)

Query  277  LSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQR  336
            L   E  ++ RD +I  L          TA  + ARR++      +         L +Q 
Sbjct  205  LQEFEAAIKQRDGIITQL----------TANLQQARREKDETMREFLELTEQSQKLQIQF  254

Query  337  DYEAGAGDKEKKPVCTNPLSILEA---VMAHCKKMQERMSAQLAAAESRQKKLEMEKLQL  393
                 +         +    +L+A   ++ H    Q+++  Q    E  QKK E   +Q+
Sbjct  255  QQLQASETLRNSTHSSTAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQI  310

Query  394  QALEQEHKKLAARLEEE-RGKNKQVVLMLVKECKQLSGKVIEEAQKL----------EDV  442
              L+++ K      +++    NK+ +       ++L+ K+IEE +K           + +
Sbjct  311  SFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKL  370

Query  443  MAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDL  502
            + +L+E+  + N+  + +  E   S + E Q  +++ +     E+L+ + +++    TD+
Sbjct  371  LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI  430

Query  503  KEEID-KMRKMIEQLKRGSD  521
             + ++ + ++ +EQL+   D
Sbjct  431  VQRMEQETQRKLEQLRAELD  450


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 38/156 (24%), Positives = 78/156 (50%), Gaps = 23/156 (14%)

Query  370   ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ--  427
             E+ S +L     +QK+ +M ++Q++    + +  A  L+E+    K VV  L  E  Q  
Sbjct  3119  EKPSQELLEYNIQQKQSQMLEMQVELSSMKDR--ATELQEQLSSEKMVVAELKSELAQTK  3176

Query  428   LSGKVIEEAQ-----KLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFD  482
             L  +   +AQ     +LE    +++++  + + L + L++E+++S E++  +EK+     
Sbjct  3177  LELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE-----  3231

Query  483   TEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
                   +AKL R E      KEE++ ++  +E  K+
Sbjct  3232  ------KAKLGRSEERD---KEELEDLKFSLESQKQ  3258


>gi|47117278|sp|Q96R06|SPAG5_HUMAN  Sperm-associated antigen 5 (Astrin) (Mitotic spindle associated 
protein p126) (MAP126) (Deepest)
Length=1193

 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 34/153 (22%), Positives = 73/153 (47%), Gaps = 6/153 (3%)

Query  365   CKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKE  424
             C  +QE   ++  A  + Q+K+   + +LQA E++H+++    E +  K  Q + +  K 
Sbjct  984   CSLLQE---SKEEAIRTLQRKICELQARLQAQEEQHQEVQKAKEADIEKLNQALCLRYKN  1040

Query  425   CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
              K+L   + ++ +K+ + + K  E      E+     + +R  TE +   E    + D+ 
Sbjct  1041  EKELQEVIQQQNEKILEQIDKSGELISLREEVTHLTRSLRRAETETKVLQEALAGQLDSN  1100

Query  485   REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
              + +     +E+     L +E+DK+R M  ++K
Sbjct  1101  CQPMATNWIQEKVW---LSQEVDKLRVMFLEMK  1130


>gi|1730009|sp|P12270|TPR_HUMAN  Nucleoprotein TPR
Length=2349

 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 56/282 (19%), Positives = 118/282 (41%), Gaps = 46/282 (16%)

Query  266   DTLSKSELRMLLSVMEG-----------ELEARDLVIEALRELKWFTGIKTAKWENARRK  314
             D + K   +++ SV EG           E ++++ ++E LR ++    I   ++E A+ +
Sbjct  1161  DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE  1220

Query  315   EVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKM------  368
              +  ++R            LQ   ++   ++EK  V    ++  E +M   + M      
Sbjct  1221  SLRYRQRVELLERE-----LQELEDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMET  1275

Query  369   -------QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLML  421
                    +ER+   L   +++ +KLE++ L LQ    E  + +  L+ E    K+++   
Sbjct  1276  NKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAE----KKLLEED  1331

Query  422   VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEF  481
             VK  K  +  ++ + QK  D     +              +EK   T+   Q+ +++   
Sbjct  1332  VKRWKARNQHLVSQ-QKDPDTEEYRKLL------------SEKEVHTKRIQQLTEEIGRL  1378

Query  482   DTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
               E  +  A L   +     LKE+++K+R   E +++  D+K
Sbjct  1379  KAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK  1420


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 48/215 (22%), Positives = 95/215 (44%), Gaps = 23/215 (10%)

Query  307  KWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHC  365
            K EN R  + ++ E         P L  QR+      + E+       LS+ LE  M   
Sbjct  413  KLENKRINK-YLDEIVKEVEAKAPILKRQRE------EYERAQKAVASLSVKLEQAMKEI  465

Query  366  KKMQE---RMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG----KNKQVV  418
            +++QE   + + Q +  E   +++E   +Q++ L Q+ + L   LEE RG    ++++V 
Sbjct  466  QRLQEDTDKANKQSSVLERDNRRME---IQVKDLSQQIRVLLMELEEARGNHVIRDEEVS  522

Query  419  LMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME-AQMEKQ  477
               +    ++  + +   + +E++  + +       EL E    E++ +T  +  +++ +
Sbjct  523  SADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK  582

Query  478  LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKM  512
            L    TE EQLR    +   H   L + I + R M
Sbjct  583  LESALTELEQLR----KSRQHQMQLVDSIVRQRDM  613


>gi|62288025|sp|Q66GS9|CEP4_HUMAN  Centrosomal protein 4 (Centrosomal protein of 135 kDa) (Cep135 
protein)
Length=1140

 Score = 39.3 bits (90),  Expect = 0.017
 Identities = 48/249 (19%), Positives = 103/249 (41%), Gaps = 31/249 (12%)

Query  342  AGDKEKKPVCTNPLSIL-EAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEH  400
            AGD   +    N L I+ E +       Q R+S +    ES Q ++   K+  + +++ +
Sbjct  656  AGDSSHQKTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQI---KILEEKIDELN  712

Query  401  KKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeel  460
             K+ ++ +EE    K+ + ++ KE   L   V E+ +K+ ++   L              
Sbjct  713  LKMTSQ-DEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENL--------------  757

Query  461  SAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGS  520
             A K ++    AQM+  +SE ++   QL+  L   +     L+ ++D   K ++++ R  
Sbjct  758  -ANKEKAV---AQMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSR  813

Query  521  DSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVKPSTG  580
            +           K+ R +   + T     + ++ + +   +  + MK        + S  
Sbjct  814  EI--------AFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRW  865

Query  581  SPLVSANAK  589
              L++A  K
Sbjct  866  ESLMAAKEK  874


>gi|32470610|sp|Q08378|GOGA3_HUMAN  Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated 
protein of 170 kDa) (GCP170)
Length=1498

 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 50/198 (25%), Positives = 86/198 (43%), Gaps = 27/198 (13%)

Query  369  QERMSAQLAAAESRQKKLEMEKL-------QLQALEQEHKKLAARLE------EERGKNK  415
            +ER+     +A S +++LE  KL       QL+AL+QEH  L  +L       + R ++ 
Sbjct  681  RERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSL  740

Query  416  QVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEK----RRSTEME  471
              +     E +   G++  EA   ED +  L+ EK       +   + K    R +  +E
Sbjct  741  DALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLE  800

Query  472  AQMEKQLSEFDTEREQLRAKLNREE---AHTTDLKEEIDKMRK-------MIEQLKRGSD  521
               E+     +  RE+L  K  + E     T  LK+++ K+++       M+E  +R + 
Sbjct  801  EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDAT  860

Query  522  SKPSLSLPRKTKDRRLVS  539
            SK  L    K   +RL S
Sbjct  861  SKDQLISELKATRKRLDS  878


 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 45/185 (24%), Positives = 81/185 (43%), Gaps = 36/185 (19%)

Query  340   AGAGDKEKKPVCTNPLSILEA---VMAHCKKMQERMSAQLAAA------ESRQKKLEME-  389
             A  G  +        +  LEA    ++H K + E+   ++ A       ESR+K LE+E 
Sbjct  1029  AQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELED  1088

Query  390   --------KLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLED  441
                     + +++ LE+ +KKLA  LE E+GK        +    Q +  + E    LE 
Sbjct  1089  ELQESRGFRKKIKRLEESNKKLALELEHEKGK--------LTGLGQSNAALREHNSILET  1140

Query  442   VMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
              +A   + +    +L  ++ A  +R  E + QM+  +       + L+A L +E+     
Sbjct  1141  ALA---KREADLVQLNLQVQAVLQRKEEEDRQMKHLV-------QALQASLEKEKEKVNS  1190

Query  502   LKEEI  506
             LKE++
Sbjct  1191  LKEQV  1195


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 31/169 (18%), Positives = 72/169 (42%), Gaps = 14/169 (8%)

Query  347  KKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAAR  406
            ++   T+ L   +A ++  + +++    QLA A+  + +L+ E   +Q  +     L   
Sbjct  553  ERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEH  612

Query  407  LEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRR  466
            L+ E     Q +        +  G++  + Q +E  M   E    +           +  
Sbjct  613  LKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQI----------QEA  662

Query  467  STEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQ  515
             T +E  ++++L EF+ ERE    +L R       L++++++++  + Q
Sbjct  663  KTMVEEDLQRRLEEFEGERE----RLQRMADSAASLEQQLEQVKLTLLQ  707


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 60/272 (22%), Positives = 106/272 (38%), Gaps = 41/272 (15%)

Query  258  SRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFT-----GIKTAKWE---  309
            SR++  D       EL+  L  ++GE  +R+  I  L+  K          K+ K E   
Sbjct  735  SREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDR  794

Query  310  NARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQ  369
             ARR E   +E       ++    L+ +    +G  E     T       A+    +K++
Sbjct  795  GARRLEEGTEET------SETLEKLREELAIKSGQVEHLQQET------AALKKQMQKIK  842

Query  370  ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV---VLMLVKECK  426
            E+   Q    E+ ++    +   +  L+   K+L + L+E R +  QV         E  
Sbjct  843  EQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELS  902

Query  427  QLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTERE  486
            +L  +V +  Q + D+   L+             SA+K R      +ME  L     ++E
Sbjct  903  RLHREVAQVRQHMADLEGHLQ-------------SAQKERD-----EMETHLQSLQFDKE  944

Query  487  QLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
            Q+ A     EA    ++E   + RK I + K+
Sbjct  945  QMVAVTEANEALKKQIEELQQEARKAITEQKQ  976


>gi|83304912|sp|P12883|MYH7_HUMAN  Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta)
Length=1935

 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 66/293 (22%), Positives = 121/293 (41%), Gaps = 45/293 (15%)

Query  267   TLSKSELRMLLSVMEGE--LEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGR  324
             T  +++ R +L+ ME +  LE RD ++     ++ F G+K   W                
Sbjct  786   TRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLY------------  833

Query  325   FNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSA----------  374
             F +     + +R+ E  +  +E     T     LE   A  K+++E+M +          
Sbjct  834   FKIKPLLKSAEREKEMASMKEE----FTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL  889

Query  375   -------QLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL---MLVKE  424
                     LA AE R  +L   K+QL+A   + K++  RLE+E   N ++      L  E
Sbjct  890   QVQAEQDNLADAEERCDQLIKNKIQLEA---KVKEMNERLEDEEEMNAELTAKKRKLEDE  946

Query  425   CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
             C +L      +   LE  +AK+E+EK  T    + L+ E     E+ A++ K+       
Sbjct  947   CSELK----RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA  1002

Query  485   REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
              +Q    L  EE     L +   K+ + ++ L+   + +  + +  +   R+L
Sbjct  1003  HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL  1055


 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 38/153 (24%), Positives = 74/153 (48%), Gaps = 13/153 (8%)

Query  363   AHCKKMQERMSA-----QLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
             AH ++M++ M       Q    E+ Q  L+  K QLQ LE   ++L   LE E+ +N + 
Sbjct  1777  AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAES  1836

Query  418   VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
             V    K  ++   ++ E   + E+    L   +   ++L+ ++ A KR++ E E Q    
Sbjct  1837  V----KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN  1892

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMR  510
             LS+F     +++ +L+  E      + +++K+R
Sbjct  1893  LSKF----RKVQHELDEAEERADIAESQVNKLR  1921


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 35/177 (19%), Positives = 72/177 (40%), Gaps = 13/177 (7%)

Query  355   LSILEAVMAHCKKMQERMS---AQLAAA-------ESRQKKLEMEKLQLQALEQEHKKLA  404
             L  LE      K +QE +S    QL ++       E  +K+LE EK++LQ+  +E +   
Sbjct  1492  LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE---  1548

Query  405   ARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEK  464
             A LE E GK  +  L   +   ++  K+ E+ +++E                 +  +  +
Sbjct  1549  ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSR  1608

Query  465   RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD  521
               +  ++ +ME  L+E + +           +     L+  +   +  ++   R +D
Sbjct  1609  NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND  1665


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 68/301 (22%), Positives = 126/301 (41%), Gaps = 71/301 (23%)

Query  272   ELRMLLSVMEGELEARDLVIEALRELKWFTGIKTA-KWENARRKEV------FIQERYGR  324
             +++ LL   E E E   +  E       FT +K A +   ARRKE+       +QE+   
Sbjct  835   KIKPLLKSAEREKEMASMKEE-------FTRLKEALEKSEARRKELEEKMVSLLQEK---  884

Query  325   FNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQER------MSAQLAA  378
                ND  L +Q + +  A  +E+   C   +     + A  K+M ER      M+A+L A
Sbjct  885   ---NDLQLQVQAEQDNLADAEER---CDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA  938

Query  379   A------ESRQKKLEMEKLQLQALEQEHKKLAAR-----LEEERGKNKQVVLMLVKECKQ  427
                    E  + K +++ L+L   + E +K A       L EE     +++  L KE K 
Sbjct  939   KKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA  998

Query  428   LSG---KVIEEAQKLEDVM--AkleeekkktneleeelSAEKRRSTEMEA----------  472
             L     + +++ Q  ED +      + K +    + E S E+ +   M+           
Sbjct  999   LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD  1058

Query  473   ----------------QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQL  516
                             Q++++L + D E   L A++  E+A  + L++++ +++  IE+L
Sbjct  1059  LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL  1118

Query  517   K  517
             +
Sbjct  1119  E  1119


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 60/289 (20%), Positives = 124/289 (42%), Gaps = 27/289 (9%)

Query  261   KEFDVDTLSKSELRMLLSV--MEGELEARDLVI----EALRELKWFTGIKTAKWENARRK  314
             +E  V+TL+K+++++   V  +EG LE    V      A R+L+    +      +    
Sbjct  1013  EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND  1072

Query  315   EVFIQERYGR--FNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVM-------AHC  365
             +  + ER  +  F LN     ++ +   G+  ++K       +  LE  +       A  
Sbjct  1073  KQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKV  1132

Query  366   KKMQERMSAQLAAAESRQKK--------LEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
             +K++  +S +L     R ++        +EM K +    E E +K+   LEE   +++  
Sbjct  1133  EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR----EAEFQKMRRDLEEATLQHEAT  1188

Query  418   VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
                L K+      ++ E+   L+ V  KLE+EK +     +++++   +  + +A +EK 
Sbjct  1189  AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM  1248

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSL  526
                 + +  + R+K    +    DL  +  K++    +L R  D K +L
Sbjct  1249  CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL  1297


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 31/150 (20%), Positives = 64/150 (42%), Gaps = 16/150 (10%)

Query  367   KMQERMSAQLAAAESRQKKLEMEKLQ-LQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             ++Q  +S   +     + K E + +Q  + LE+  KKLA RL+E     ++ V  +  +C
Sbjct  1356  ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA----EEAVEAVNAKC  1411

Query  426   KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
               L         ++ED+M              E  +A      + +   +K L+E+  + 
Sbjct  1412  SSLEKTKHRLQNEIEDLMV-----------DVERSNAAAAALDKKQRNFDKILAEWKQKY  1460

Query  486   EQLRAKLNREEAHTTDLKEEIDKMRKMIEQ  515
             E+ +++L   +     L  E+ K++   E+
Sbjct  1461  EESQSELESSQKEARSLSTELFKLKNAYEE  1490


>gi|48474259|sp|O43150|DDEF2_HUMAN  Development and differentiation-enhancing factor 2 (Pyk2 C-terminus-associated 
protein) (PAP) (Paxillin-associated protein 
with ARFGAP activity 3) (PAG3)
Length=1006

 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 0/58 (0%)

Query  1040  VELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAA  1097
             V+ L+    N++     G T L+  C   N EC+KLLL    +  +    G TP+  A
Sbjct  604   VDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIA  661


 Score = 38.9 bits (89),  Expect = 0.022
 Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 0/53 (0%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELL  1043
             G +AL+      + +C++LLL  +A +  A+++G TPL  A    H  C ELL
Sbjct  621   GSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELL  673


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 3/101 (2%)

Query  1007  VRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACK  1066
             V  L+     ++     G T L       + EC++LL+   A+I  A + G+TPL +A +
Sbjct  604   VDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKR  663

Query  1067  NGNKECIKLLLEAGT---NRSVKTTDGWTPVHAAVDTGNVD  1104
               ++ C +LL +A +   N  V     W  +H  +D  + D
Sbjct  664   LKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDD  704


>gi|67476728|sp|P42566|EP15_HUMAN  Epidermal growth factor receptor substrate 15 (Protein Eps15) 
(AF-1p protein)
Length=896

 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 43/202 (21%), Positives = 87/202 (43%), Gaps = 50/202 (24%)

Query  327  LNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKL  386
            LN+  + LQR+      D ++K          + +     ++Q+ +  ++    +  +KL
Sbjct  338  LNNEIVDLQREKNNVEQDLKEKE---------DTIKQRTSEVQD-LQDEVQRENTNLQKL  387

Query  387  EMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkl  446
            + +K Q+Q L  E  +  A+LEE              + K++  K  EEAQ +  + A  
Sbjct  388  QAQKQQVQELLDELDEQKAQLEE--------------QLKEVRKKCAEEAQLISSLKA--  431

Query  447  eeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI  506
                                  E+ +Q E Q+S ++ E  + R +L+R +  T +L+E +
Sbjct  432  ----------------------ELTSQ-ESQISTYEEELAKAREELSRLQQETAELEESV  468

Query  507  DKMRKMIEQLKRG-SDSKPSLS  527
            +  +  +E L++   DS+  +S
Sbjct  469  ESGKAQLEPLQQHLQDSQQEIS  490


>gi|55583998|sp|Q9NUQ3|TXLNG_HUMAN  Gamma-taxilin (Lipopolysaccharide-specific response protein 5)
Length=528

 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 27/122 (22%), Positives = 64/122 (52%), Gaps = 7/122 (5%)

Query  401  KKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeel  460
            KK A  LEE R   KQ+ ++  K+ + +  KV  +++  + ++A+ + E           
Sbjct  161  KKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRHNK  220

Query  461  SAEK---RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI----DKMRKMI  513
            + ++   +++ E E + ++  + F    ++++A+L + + H   L++E     +K++K+I
Sbjct  221  TLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQENIELGEKLKKLI  280

Query  514  EQ  515
            EQ
Sbjct  281  EQ  282


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 38/163 (23%), Positives = 78/163 (47%), Gaps = 17/163 (10%)

Query  363  AHCKKMQERMSAQLAAAESRQKKLEMEKLQL-QALEQEHKKLAARLE--EERGKNKQVVL  419
            AH +   + + AQL   +    KL  E ++L + L++  ++ A R E  ++  K K++  
Sbjct  242  AHFQITLDEIQAQLEQHDIHNAKLRQENIELGEKLKKLIEQYALREEHIDKVFKRKELQQ  301

Query  420  MLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM----EAQME  475
             LV    Q + ++I+EA +             +  E   + + E R   E     E Q++
Sbjct  302  QLVDAKLQQTTQLIKEADEKHQ----------REREFLLKEATESRHKYEQMKQQEVQLK  351

Query  476  KQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
            +QLS +  + E+ +  + +     T  ++E++KM K I++L++
Sbjct  352  QQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKLEK  394


>gi|50400977|sp|Q7Z4S6|KI21A_HUMAN  Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 
antigen)
Length=1674

 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 42/206 (20%), Positives = 85/206 (41%), Gaps = 33/206 (16%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKL---AARLEEERGKNKQVVLMLVKEC  425
            +E+     +  E + + +  E  +LQA ++EH +L    ++ E++  K +Q V+ + K  
Sbjct  711  EEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTK  770

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
             +L  ++ EE +K                        E RR+ E+ AQ++K   + D + 
Sbjct  771  VRLMKQMKEEQEKAR--------------------LTESRRNREI-AQLKKDQRKRDHQL  809

Query  486  EQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTE  545
              L A+   +E       EE+  +R+ +  +      K +         R+L S     +
Sbjct  810  RLLEAQKRNQEVVLRRKTEEVTALRRQVRPMSDKVAGKVT---------RKLSSSDAPAQ  860

Query  546  GTVTRSVACQTDLVTENADHMKKLPL  571
             T + + A +TD     A    ++P+
Sbjct  861  DTGSSAAAVETDASRTGAQQKMRIPV  886


>gi|18202960|sp|Q9HCX4|TRPC7_HUMAN  Short transient receptor potential channel 7 (TrpC7) (TRP7 protein)
Length=862

 Score = 38.5 bits (88),  Expect = 0.029
 Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 8/87 (9%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCED--GHSALYSAAKNGHTDCVRLLLSAEAQVNAAD  1021
             +A  GN+ ++  +L EE   +N++C D  G +AL  A  N H +   LLL  E      D
Sbjct  50    SAEYGNIPVVRKML-EESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGD  108

Query  1022  KNGFTPLCAAAAQGHFECVELLISYDA  1048
                   L  A ++G+   VE ++++ A
Sbjct  109   -----ALLLAISKGYVRIVEAILNHPA  130


>gi|29840818|sp|Q9UKE5|TNIK_HUMAN  TRAF2 and NCK-interacting kinase
Length=1360

 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 51/203 (25%), Positives = 101/203 (49%), Gaps = 18/203 (8%)

Query  335  QRDYE-AGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQL  393
            + +YE +G+ ++E++     P SIL  +       ++ +  QLA  E R + L  ++L+ 
Sbjct  318  ETEYEYSGSEEEEEENDSGEPSSILN-LPGESTLRRDFLRLQLANKE-RSEALRRQQLEQ  375

Query  394  QALE-QEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkk  452
            Q  E +EHK+   +L  ER K        ++E K+   ++ E+ ++ +++  + E E+++
Sbjct  376  QQRENEEHKR---QLLAERQKR-------IEEQKEQRRRLEEQQRREKELRKQQEREQRR  425

Query  453  tneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLK----EEIDK  508
              E +     E+RR+   +  + +QL E   + E L+ +L  E+A   + K    EE  +
Sbjct  426  HYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQ  485

Query  509  MRKMIEQLKRGSDSKPSLSLPRK  531
              ++  QLK+  D   SL   R+
Sbjct  486  AERLQRQLKQERDYLVSLQHQRQ  508


>gi|23822112|sp|Q9P2E9|RRBP1_HUMAN  Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa 
ribosome receptor homolog) (ES/130-related protein)
Length=1410

 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 55/237 (23%), Positives = 106/237 (44%), Gaps = 39/237 (16%)

Query  278  SVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRD  337
            S++  E EA+ L IE L E     GI    W  A +K              DP   L+R 
Sbjct  659  SMVFNEGEAQRL-IEILSEK---AGIIQDTWHKATQK-------------GDPVAILKRQ  701

Query  338  YEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALE  397
             E      EK+ +            +  +++ + M+A+ A A + + K+   K QL A E
Sbjct  702  LE------EKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKV---KKQLVARE  752

Query  398  QEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnele  457
            QE   + AR++    ++       VKE +QL GK+    ++LE+      +  +   E  
Sbjct  753  QEITAVQARMQASYREH-------VKEVQQLQGKIRTLQEQLEN--GPNTQLARLQQENS  803

Query  458  eelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
                A  + ++++E++   +L++    R++L +K+++E    ++   + ++ RK +E
Sbjct  804  ILRDALNQATSQVESKQNAELAKL---RQEL-SKVSKELVEKSEAVRQDEQQRKALE  856


 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 46/243 (18%), Positives = 104/243 (42%), Gaps = 26/243 (10%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVK--  423
             K++ +  ++   + E+ QK+L+    +L   +  H  L A  E+ + + +Q+  +  K  
Sbjct  864   KQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQ  923

Query  424   --------ECKQLSGK--VIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEA-  472
                     +C++LSG    ++EA+     + +     +   E  +   A+  ++++ EA 
Sbjct  924   SSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEAD  983

Query  473   -------QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK-P  524
                    ++E Q+S  + E  +LR  + +++    DL+E+  K  + +   ++    K  
Sbjct  984   QQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLL  1043

Query  525   SLSLPRKTKDRRLVSISVGTEGTVTR-----SVACQTDLVTENADHMKKLPLTMPVKPST  579
             SL+  ++  +++L  I   T   +       SV  Q +      D  +K P  +   P+ 
Sbjct  1044  SLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAP  1103

Query  580   GSP  582
               P
Sbjct  1104  AEP  1106


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 17/64 (26%), Positives = 38/64 (59%), Gaps = 1/64 (1%)

Query  461  SAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNRE-EAHTTDLKEEIDKMRKMIEQLKRG  519
            +AEK ++   EA+++KQL   + E   ++A++      H  ++++   K+R + EQL+ G
Sbjct  731  AAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENG  790

Query  520  SDSK  523
             +++
Sbjct  791  PNTQ  794


>gi|50403793|sp|Q96L93|SNX23_HUMAN  Kinesin-like motor protein C20orf23 (Sorting nexin 23)
Length=1317

 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 34/143 (23%), Positives = 73/143 (51%), Gaps = 10/143 (6%)

Query  380  ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLML-------VKECKQLSGKV  432
            + +  KLE+EK +L+  E+E   L A LEE+  + ++++ +L       V+E K+    +
Sbjct  738  DEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEKRDLEGI  797

Query  433  IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKL  492
             E   ++++  A  +E+ ++  + +      KRR       +EK L +   +++ L+ ++
Sbjct  798  RESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQ---QKDILKKEV  854

Query  493  NREEAHTTDLKEEIDKMRKMIEQ  515
              E+     LK E DK  +++E+
Sbjct  855  QEEQEILECLKCEHDKESRLLEK  877


 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 41/191 (21%), Positives = 90/191 (47%), Gaps = 40/191 (20%)

Query  355  LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEK-----LQLQALEQEH---------  400
            L  LE+     ++M+E+  +  A  E  Q+++E ++     +QLQ  +QE          
Sbjct  606  LEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHI  665

Query  401  ----KKLAA---RLEEERGKNKQVV-LMLVKECKQLSGKVIEEAQKLEDVMAkleeekkk  452
                K L A   + EEER + +Q + L   ++ ++   +V EE Q+L+++          
Sbjct  666  ENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKEL----------  715

Query  453  tneleeelSAEK----RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDK  508
                     AEK    +   +++ + ++Q ++ + E+++L  +   +      L+E++ +
Sbjct  716  ----NNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLRE  771

Query  509  MRKMIEQLKRG  519
             ++MI+ L+RG
Sbjct  772  KQEMIQLLRRG  782


>gi|3041706|sp|P13533|MYH6_HUMAN  Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha)
Length=1939

 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 38/153 (24%), Positives = 74/153 (48%), Gaps = 13/153 (8%)

Query  363   AHCKKMQERMSA-----QLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
             AH ++M++ M       Q    E+ Q  L+  K QLQ LE   ++L   LE E+ +N + 
Sbjct  1779  AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES  1838

Query  418   VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
             V    K  ++   ++ E   + E+    L   +   ++L+ ++ A KR++ E E Q    
Sbjct  1839  V----KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTN  1894

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMR  510
             LS+F     +++ +L+  E      + +++K+R
Sbjct  1895  LSKF----RKVQHELDEAEERADIAESQVNKLR  1923


 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 34/156 (21%), Positives = 74/156 (47%), Gaps = 15/156 (9%)

Query  367   KMQERMSAQLAAAESRQKKLEMEK---LQLQALEQEHKKLAARLEEERGKNKQVVLMLVK  423
             +++E++  +      +  K+E E+   LQLQ   +E++     LEEE    +     + K
Sbjct  1077  QLEEKLKKKEFDINQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEK  1136

Query  424   ECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDT  483
                 LS ++ E +++LE+                 ++   K+R  E + +M + L E   
Sbjct  1137  LRSDLSRELEEISERLEEA----------GGATSVQIEMNKKREAEFQ-KMRRDLEEATL  1185

Query  484   EREQLRAKLNREEAHT-TDLKEEIDKMRKMIEQLKR  518
             + E   A L ++ A +  +L E+ID ++++ ++L++
Sbjct  1186  QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK  1221


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 59/273 (21%), Positives = 115/273 (42%), Gaps = 41/273 (15%)

Query  284   LEARDLVIEALRELKWFTGIKTAKW-------------ENARRKEVFIQERYGRFNLNDP  330
             +E RD ++     ++ F G+K   W                 ++   ++E +GR      
Sbjct  807   VERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKET--  864

Query  331   FLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQ---LAAAESRQKKLE  387
                L++  EA   + E+K V         +++     +Q ++ A+   L  AE R  +L 
Sbjct  865   ---LEKS-EARRKELEEKMV---------SLLQEKNDLQLQVQAEQDNLNDAEERCDQLI  911

Query  388   MEKLQLQALEQEHKKLAARLEEERGKNKQVVL---MLVKECKQLSGKVIEEAQKLEDVMA  444
               K+QL+A   + K++  RLE+E   N ++      L  EC +L     ++   LE  +A
Sbjct  912   KNKIQLEA---KVKEMNERLEDEEEMNAELTAKKRKLEDECSELK----KDIDDLELTLA  964

Query  445   kleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKE  504
             K+E+EK  T    + L+ E     E+ A++ K+        +Q    L  EE     L +
Sbjct  965   KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK  1024

Query  505   EIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
                K+ + ++ L+   + +  + +  +   R+L
Sbjct  1025  SKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL  1057


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 34/177 (19%), Positives = 70/177 (39%), Gaps = 13/177 (7%)

Query  355   LSILEAVMAHCKKMQERMS----------AQLAAAESRQKKLEMEKLQLQALEQEHKKLA  404
             L  LE      K +QE +S            +   E  +K+LE+EKL+LQ+  +E +   
Sbjct  1494  LEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE---  1550

Query  405   ARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEK  464
             A LE E GK  +  L   +   ++  K+ E+ +++E      +          +  +  +
Sbjct  1551  ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSR  1610

Query  465   RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD  521
                  ++ +ME  L+E + +           +     L+  +   +  ++   R +D
Sbjct  1611  NEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND  1667


>gi|29427585|sp|O95819|M4K4_HUMAN  Mitogen-activated protein kinase kinase kinase kinase 4 (MAPK/ERK 
kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) 
(HPK/GCK-like kinase HGK) (Nck-interacting kinase)
Length=1239

 Score = 38.1 bits (87),  Expect = 0.037
 Identities = 52/215 (24%), Positives = 93/215 (43%), Gaps = 33/215 (15%)

Query  323  GRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESR  382
            G   L   FL LQ++      +KE+         + E  +    + QE    QL A   R
Sbjct  348  GESTLRRDFLRLQQE------NKERSEALRRQQLLQEQQL----REQEEYKRQLLA--ER  395

Query  383  QKKLEMEKLQLQALE-QEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLED  441
            QK++E +K Q + LE Q+ ++  AR ++ER + ++                 EE ++LE+
Sbjct  396  QKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQ---------------EEKRRLEE  440

Query  442  VMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
            +     E ++K  E       EKRR    +  + +QL E     E L+ +L +E+A   +
Sbjct  441  L-----ERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLE  495

Query  502  LKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRR  536
             +    +  +  E+L+R    + +  L  +   RR
Sbjct  496  CRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRR  530


>gi|42558938|sp|Q8TD31|CCHCR_HUMAN  Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil 
rod protein) (Putative gene 8 protein) (Pg8)
Length=782

 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 21/57 (36%), Positives = 34/57 (59%), Gaps = 1/57 (1%)

Query  359  EAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEE-ERGKN  414
            EA   H K +      Q  AA+ +++  E+ +LQ +A ++E ++LA RL+E ER KN
Sbjct  625  EARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKN  681


>gi|32699595|sp|Q96CN9|GCC1_HUMAN  GRIP and coiled-coil domain-containing protein 1 (Golgi coiled 
coil protein 1)
Length=775

 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 54/257 (21%), Positives = 121/257 (47%), Gaps = 21/257 (8%)

Query  352  TNPLSILEA-VMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEE  410
            T   S +EA  +A  KKM++ +      AE  + +LE E   LQ    E K      + +
Sbjct  176  TQEKSRMEASYLADKKKMKQDLEDASNKAEEERARLEGELKGLQEQIAETKARLITQQHD  235

Query  411  RGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM  470
            R + +    ++++E ++L  +   + Q LE     L  E+ +        +AE+    E+
Sbjct  236  RAQEQSDHALMLRELQKLLQEERTQRQDLE-----LRLEETREALAGRAYAAEQMEGFEL  290

Query  471  EA-QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMR-----KMIEQLKRGSDSKP  524
            +  Q+ +++ E  +E + +R + N+ +    +L+EE  +++     ++ +++++ + ++ 
Sbjct  291  QTKQLTREVEELKSELQAIRDEKNQPDPRLQELQEEAARLKSHFQAQLQQEMRKTALAED  350

Query  525  SLSLPRKTKDRRLVS----ISVGTEGTVTRSVACQTD--LVTENADHMKKLPL---TMPV  575
             L    + +++R+ +    IS  +E   T   A Q D   + +  + + +L L   T+ +
Sbjct  351  QLRQQSQVEEQRVAALENQISEVSELLGTYEKAKQKDQLAIQKLKERILQLDLENKTLAL  410

Query  576  KPSTGSPLVSANAKGSV  592
              S+ SPL S   + S+
Sbjct  411  AASSRSPLDSHGEESSL  427


>gi|55584162|sp|P40222|TXLNA_HUMAN  Alpha-taxilin
Length=546

 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 32/143 (22%), Positives = 80/143 (55%), Gaps = 7/143 (4%)

Query  383  QKKLEMEKLQLQALEQEHKKLAARLEE--ERGKNKQVVLMLVKECKQLSGKVIE-EAQKL  439
            Q ++E    +   L QE+ +LA RL++  E+ + ++  +  V + K L  ++++ + Q+ 
Sbjct  285  QLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQQLVDAKLQQA  344

Query  440  EDVMAkleeekkktneleeelSAEKRRSTEM----EAQMEKQLSEFDTEREQLRAKLNRE  495
            ++++ + EE  ++  +   + + E +R  E+    E  +++QL+ +  + E+ +  L++ 
Sbjct  345  QEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTEKFEEFQNTLSKS  404

Query  496  EAHTTDLKEEIDKMRKMIEQLKR  518
                T  K+E++KM K I++L++
Sbjct  405  SEVFTTFKQEMEKMTKKIKKLEK  427


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 27/122 (22%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query  401  KKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeel  460
            KK A  LEE R   KQ+ L+  K+ + +  K     +  + V+A+ + E           
Sbjct  194  KKYAELLEEHRNSQKQMKLLQKKQSQLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNR  253

Query  461  SAEK---RRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEE----IDKMRKMI  513
            S ++   +R+ E E + ++  S F      ++ ++ +     + L++E     ++++K+I
Sbjct  254  SLKEEGVQRAREEEEKRKEVTSHFQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLI  313

Query  514  EQ  515
            EQ
Sbjct  314  EQ  315


>gi|6686048|sp|Q9Y210|TRPC6_HUMAN  Short transient receptor potential channel 6 (TrpC6)
Length=931

 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 8/87 (9%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCED--GHSALYSAAKNGHTDCVRLLLSAEAQVNAAD  1021
             AA  GN+ ++  +L EE   +N +C D  G +AL  A  N H +   LLL  E      D
Sbjct  105   AAEYGNIPVVRKML-EECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGD  163

Query  1022  KNGFTPLCAAAAQGHFECVELLISYDA  1048
                   L  A ++G+   VE ++S+ A
Sbjct  164   -----ALLLAISKGYVRIVEAILSHPA  185


>gi|3043372|sp|P11055|MYH3_HUMAN  Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic 
myosin heavy chain) (SMHCE)
Length=1940

 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 40/165 (24%), Positives = 67/165 (40%), Gaps = 31/165 (18%)

Query  359   EAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVV  418
             + V+A  K   E   A+L A+    + L  E  +L+   +E       ++ E    +Q +
Sbjct  1451  DKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI  1510

Query  419   LMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME-AQMEKQ  477
               L ++  + +GK I E +K                          R+  E+E A ++  
Sbjct  1511  ADLTEQIAE-NGKTIHELEK-------------------------SRKQIELEKADIQLA  1544

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDK----MRKMIEQLKR  518
             L E +   E   AK+ R +   T +K EID+      + IEQLKR
Sbjct  1545  LEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR  1589


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 43/174 (24%), Positives = 78/174 (44%), Gaps = 12/174 (6%)

Query  346   EKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAA  405
             E K  C    + LEA +   + +   +     A E    +LE  K + + LEQE     A
Sbjct  1456  EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQE----IA  1511

Query  406   RLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKR  465
              L E+  +N + +  L K  KQ+  +  +    LE+  A LE E+ K   +       + 
Sbjct  1512  DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI-------QL  1564

Query  466   RSTEMEAQMEKQLSEFDTEREQLRAKLNRE-EAHTTDLKEEIDKMRKMIEQLKR  518
               T+++++++++++E D E EQL+    R  E   + L  E+    + I   K+
Sbjct  1565  ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKK  1618


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 38/146 (26%), Positives = 64/146 (43%), Gaps = 8/146 (5%)

Query  369   QERMSAQLAAAESRQKKLEMEKLQLQA-LEQEHKKLAARLEEERGKNKQVVLMLVKECKQ  427
             QE +  QLA  E R   L+ E  +L+A LEQ  +      +E    N++V L+  +    
Sbjct  1665  QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ----  1720

Query  428   LSGKVIEEAQKLE-DVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTERE  486
              +  +I   +KLE D+M    E +  + +        K+  T+     E+   E DT   
Sbjct  1721  -NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAH  1779

Query  487   QLRAKLNREEAHTTDLKEEIDKMRKM  512
               R K N E+    DL+  +D+  ++
Sbjct  1780  LERMKKNLEQT-VKDLQHRLDEAEQL  1804


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 42/168 (25%), Positives = 73/168 (43%), Gaps = 10/168 (5%)

Query  373   SAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL---MLVKECKQLS  429
             S  L  AE R  +L   K QL+A   + K++  R E+E   N ++      L  EC +L 
Sbjct  896   SENLLDAEERCDQLIKAKFQLEA---KIKEVTERAEDEEEINAELTAKKRKLEDECSELK  952

Query  430   GKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLR  489
                 ++   LE  +AK+E+EK  T    + L+ E     E  A++ ++        +Q  
Sbjct  953   ----KDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL  1008

Query  490   AKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
               L  EE     L +   K+ + +E L+   + +  L +  +   R+L
Sbjct  1009  DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKL  1056


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 30/131 (22%), Positives = 65/131 (49%), Gaps = 6/131 (4%)

Query  399  EHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnelee  458
            E +K  A ++EE  K K  +     + K+L  K++   Q+  D+  +++ E +   + EE
Sbjct  845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE  904

Query  459  elSAEKRRSTEMEAQMEKQLSEFDTERE---QLRAKLNREEAHTTDLKEEIDKMR---KM  512
                  +   ++EA++++     + E E   +L AK  + E   ++LK++ID +      
Sbjct  905  RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK  964

Query  513  IEQLKRGSDSK  523
            +E+ K  +++K
Sbjct  965  VEKEKHATENK  975


>gi|77416379|sp|Q9UPN4|AZI1_HUMAN  5-azacytidine-induced protein 1 (Pre-acrosome localization protein 
1) (Centrosomal protein of 131 kDa) (Cep131 protein)
Length=1083

 Score = 37.7 bits (86),  Expect = 0.049
 Identities = 67/298 (22%), Positives = 118/298 (39%), Gaps = 43/298 (14%)

Query  256  IISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALREL----------KWFTG-IK  304
            ++S K E  V  L + + R    V + + +  +L I+ L+EL          KW +   K
Sbjct  643  VLSEKCEAVVAELKQEDQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTK  701

Query  305  TAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAH  364
              K    R  E  IQ+   R       L    + E    D+     C      L   +  
Sbjct  702  KIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLER  761

Query  365  CKK---MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLML  421
             K+    QER  A+    +  Q+ LE E+    AL+Q+ ++L + + EER +  Q     
Sbjct  762  EKEALGQQERERAR----QRFQQHLEQEQW---ALQQQRQRLYSEVAEERERLGQQAARQ  814

Query  422  VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEF  481
              E ++L  ++ E +  L   +                   EK R    E Q  +   E 
Sbjct  815  RAELEELRQQLEESSSALTRAL---------------RAEFEKGR----EEQERRHQMEL  855

Query  482  DTEREQLRAKLNREEAHTTDLKEE--IDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
            +T ++QL  +    EA  T  +E   +++ +++ E++++G D +  L + R   D  L
Sbjct  856  NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMAL  913


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 58/242 (23%), Positives = 106/242 (43%), Gaps = 26/242 (10%)

Query  306   AKWENARRKEVFIQERYGRFNLND--PFLALQRD-YEAGAGDKEKKPVCTNPLSILEAVM  362
             A++E  R +    QER  +  LN     L L+R  +EAG   KE+  +      + E + 
Sbjct  838   AEFEKGREE----QERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIR  893

Query  363   AHCKKMQE----RMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVV  418
                 K  E    R+ A +A A+   +K         A E   K+L  + E E  + +Q  
Sbjct  894   KGRDKEIELVIHRLEADMALAKEESEK---------AAESRIKRLRDKYEAELSELEQSE  944

Query  419   LMLVKECKQLSGKVIE---EAQKLEDVMAkleeekkktneleeelSAEKRRSTE-MEAQM  474
               L + C +L G++ E   E  +L+ ++ + E   +    + E+LS+E+    + +  + 
Sbjct  945   RKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEF  1004

Query  475   EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
             E +L+  + E  Q +A+L   +A      EE+   R++   L R  ++  SL    +   
Sbjct  1005  EDRLAASEEETRQAKAELATLQARQQLELEEVH--RRVKTALARKEEAVSSLRTQHEAAV  1062

Query  535   RR  536
             +R
Sbjct  1063  KR  1064


>gi|62512161|sp|O95239|KIF4A_HUMAN  Chromosome-associated kinesin KIF4A (Chromokinesin)
Length=1232

 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 45/202 (22%), Positives = 87/202 (43%), Gaps = 34/202 (16%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKL-EMEKLQLQALEQEHKKLAARLEEE------  410
            LE +    +K +  +  Q A  ++ Q KL E  + +LQ LE +   L  +L E+      
Sbjct  566  LEVINLQKEKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKL  625

Query  411  RGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM  470
            +   ++ V  L +E + +  + ++  +++++                    AEK R  + 
Sbjct  626  KESTERTVSKLNQEIRMMKNQRVQLMRQMKE-------------------DAEKFRQWKQ  666

Query  471  EAQMEK-QLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS-KPSLSL  528
            +   E  QL E D +R+    KL R      + +++ + +R+  E+    +   K +L  
Sbjct  667  KKDKEVIQLKERDRKRQYELLKLER------NFQKQSNVLRRKTEEAAAANKRLKDALQK  720

Query  529  PRKTKDRRLVSISVGTEGTVTR  550
             R+  D+R  + S G EGT  R
Sbjct  721  QREVADKRKETQSRGMEGTAAR  742


>gi|71153214|sp|Q68D86|CR014_HUMAN  Hypothetical protein C18orf14
Length=513

 Score = 37.4 bits (85),  Expect = 0.064
 Identities = 49/251 (19%), Positives = 112/251 (44%), Gaps = 25/251 (9%)

Query  274  RMLLSVMEGELEARDLVIEALRELKW-FTGIKTAKWENARRKEVFIQERYGRFNLNDPFL  332
            R + + +E E+E  +    AL   KW +  +K +K +N +  ++ + +       ND   
Sbjct  275  REMRTALEKEIERLE---SALSLWKWKYEELKESKPKNVKEFDILLGQH------NDEMQ  325

Query  333  ALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQ  392
             L  + +  +  +  K          + V+   +   ER+ A+  +   +++ LE EK  
Sbjct  326  ELSGNIKEESKSQNSK----------DRVICELRAELERLQAENTSEWDKREILEREK--  373

Query  393  LQALEQEHKKLAARLEE-ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekk  451
             Q LE+E+++L  +++E E   +K+  L    +        I+  +K ++++       K
Sbjct  374  -QGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYK  432

Query  452  ktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRK  511
               + +  + AE   +     Q E ++ +     E+LR  LN++E    D   +I K+++
Sbjct  433  LNRQYQANI-AELTHANNRVDQNEAEVKKLRLRVEELRQGLNQKEDELDDSLNQIRKLQR  491

Query  512  MIEQLKRGSDS  522
             +++ K  +++
Sbjct  492  SLDEEKERNEN  502


>gi|10720321|sp|Q9UL62|TRPC5_HUMAN  Short transient receptor potential channel 5 (TrpC5) (Htrp-5) 
(Htrp5)
Length=973

 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 45/175 (25%), Positives = 71/175 (40%), Gaps = 31/175 (17%)

Query  944   PLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGL--DINYSCED--GHSALYSAA  999
             PL +      L+        A  +G+   +   L E  +  ++N +C D  G SAL  A 
Sbjct  19    PLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAI  78

Query  1000  KNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQT  1059
             +N + + + LLL+    V  A       L  A  +     VELL+SY             
Sbjct  79    ENENLEIMELLLNHSVYVGDA-------LLYAIRKEVVGAVELLLSYRR-----------  120

Query  1060  PLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRI  1114
                    +G K+   L+++  T  S  T D  TP+  A  T N + +KLL+  R+
Sbjct  121   ------PSGEKQVPTLMMD--TQFSEFTPD-ITPIMLAAHTNNYEIIKLLVQKRV  166


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 33/108 (30%), Positives = 53/108 (49%), Gaps = 16/108 (14%)

Query  1011  LSAE--AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNG  1068
             LSAE  A +NA +K  +  +  A  +         I Y+ NIN     G++ L +A +N 
Sbjct  29    LSAEEKAFLNAVEKGDYATVKQALQEAE-------IYYNVNINCMDPLGRSALLIAIENE  81

Query  1069  NKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA  1116
             N E ++LLL    N SV   D    +  A+    V +++LL+ +R P+
Sbjct  82    NLEIMELLL----NHSVYVGDA---LLYAIRKEVVGAVELLLSYRRPS  122


>gi|62899891|sp|Q9HC77|CENPJ_HUMAN  Centromere protein J (Centrosomal P4.1-associated protein) (LAG-3-associated 
protein) (LYST-interacting protein 1)
Length=1338

 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 42/208 (20%), Positives = 85/208 (40%), Gaps = 30/208 (14%)

Query  332   LALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKL  391
             L L    +   GD  +  V    +  LE  +   K     ++      ES  +KL  E  
Sbjct  887   LKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKE--  944

Query  392   QLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQL-----SGKVIEEAQKLEDVMAkl  446
              +   EQ+  K  AR+EE +   K+ +  L KE K       + +   + ++ E++    
Sbjct  945   -IADFEQQKAKELARIEEFK---KEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTL-  999

Query  447   eeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI  506
                              K++  ++   ++++ +++ +   +LR+++       TDL+EEI
Sbjct  1000  -----------------KQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEI  1042

Query  507   DKMRKM-IEQLKRGSDSKPSLSLPRKTK  533
               M +  ++  KR    + SL + +K K
Sbjct  1043  KVMERFRLDAWKRAEAIESSLEVEKKDK  1070


>gi|52783153|sp|Q9Y6D9|MD1L1_HUMAN  Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest 
deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint 
MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 
181)
Length=718

 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 42/184 (22%), Positives = 93/184 (50%), Gaps = 10/184 (5%)

Query  336  RDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAES-RQKKLEMEKLQLQ  394
            ++ EAGA +K ++ +  N     + + A  K+++E+  +   A E+    K  + +LQ  
Sbjct  114  QEREAGAEEKMQEQLERNR-QCQQNLDAASKRLREKEDSLAQAGETINALKGRISELQWS  172

Query  395  ALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktn  454
             ++QE +    RLE E+ + ++ + +  K+C++ + K I+E Q  ++  A  E++ K   
Sbjct  173  VMDQEMR--VKRLESEKQELQEQLDLQHKKCQEANQK-IQELQASQEARADHEQQIKDLE  229

Query  455  eleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
            +       +      M++++ + L   + E +QLR     E AH  +++E    +++ +E
Sbjct  230  QKLSLQEQDAAIVKNMKSELVR-LPRLERELKQLR----EESAHLREMRETNGLLQEELE  284

Query  515  QLKR  518
             L+R
Sbjct  285  GLQR  288


>gi|51827892|sp|Q8IUD2|RB6I2_HUMAN  RAB6-interacting protein 2 (ERC protein 1)
Length=1116

 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 48/230 (20%), Positives = 103/230 (44%), Gaps = 16/230 (6%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
            LE     C KM+ ++     AA   +   EM   ++Q LE+E      R ++E  K +  
Sbjct  703  LEQKKEECLKMESQLKKAHEAALEARASPEMSD-RIQHLERE----ITRYKDESSKAQAE  757

Query  418  VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
            V  L++  K++  +  ++ +K+ ++  +++++ KK   L+ +   EK++S +M  +  ++
Sbjct  758  VDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR  817

Query  478  LSEFDTEREQLRAKLNREEAHTTDLKE------EIDKMRKMI---EQLKRGSDSK--PSL  526
                +   +QL+  L +++    +L+E      +I   R+M+   E+  R +  K    L
Sbjct  818  EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL  877

Query  527  SLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVK  576
             +  +   + L S+      T       +T L    A+  K L   + +K
Sbjct  878  LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK  927


 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 59/273 (21%), Positives = 120/273 (43%), Gaps = 41/273 (15%)

Query  270  KSELRML-----LSVMEGELEARDLVI---------EALRELKWFTGIKTAKWENARRKE  315
            + E++ML     LS  E E E + + +           + +LK     K A+WE  ++K 
Sbjct  402  EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKA  461

Query  316  VFIQERYGRF-----NLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQE  370
              +Q   G+        +   LALQ   E            TN  S  +    H + ++E
Sbjct  462  AGLQAEIGQVKQELSRKDTELLALQTKLE----------TLTNQFSDSK---QHIEVLKE  508

Query  371  RMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLE---EERGKNKQVV--LMLVKEC  425
             ++A+   A   Q +++  +L+L+  E    K   +++   EE+G     +  L  + + 
Sbjct  509  SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV  568

Query  426  KQLSGKVIE-EAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
            K+    V++ + + L++ +   E++     E  + L A+   +      +E+ L+E +  
Sbjct  569  KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT  628

Query  485  REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
             E+L+ + +R+E    + +EEID  +K ++ LK
Sbjct  629  IERLKEQRDRDE---REKQEEIDNYKKDLKDLK  658


>gi|42558987|sp|Q8ND30|LIPB2_HUMAN  Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting 
protein-binding protein 2) (PTPRF-interacting 
protein-binding protein 2)
Length=876

 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 70/285 (24%), Positives = 124/285 (43%), Gaps = 51/285 (17%)

Query  272  ELRMLLSVMEGELEARDLVIE-----ALRELKWFT-GIKTAKWENARRKEVFIQERYGRF  325
            +LR+ L ++E   E   L+ +     A    +WF   +      +A   E + QER  R 
Sbjct  56   DLRLALEMLELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAASNETY-QERLARL  114

Query  326  NLNDPFLALQ----RDYEAGAGDKEKK-PVCTNPLSILEAVMAHCKKMQERMSAQLAAAE  380
              +   L LQ     D     G+K +   VC      LE         +E +  +L +  
Sbjct  115  EGDKESLILQVSVLTDQVEAQGEKIRDLEVC------LEGHQVKLNAAEEMLQQELLSRT  168

Query  381  SRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLM---LVKECKQLSGKVIEEAQ  437
            S    LE +KL L     E K     +E+E+ + ++       L++E + L  KV    +
Sbjct  169  S----LETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKV----E  220

Query  438  KLEDVMAkleeekkktneleeelSAEKRRSTEME-AQMEKQLSEFDTEREQLRAKLNREE  496
            +LE+   + E                K ++T+ E AQ+++Q++  D E E+L ++L+R  
Sbjct  221  ELENERNQYEW---------------KLKATKAEVAQLQEQVALKDAEIERLHSQLSRTA  265

Query  497  AHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSIS  541
            A  ++   E D   + I++LK G +   +L L  + KDRR+  ++
Sbjct  266  ALHSESHTERD---QEIQRLKMGME---TLLLANEDKDRRIEELT  304


>gi|68840132|sp|Q96SN8|CK5P2_HUMAN  CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding 
protein C48)
Length=1893

 Score = 37.0 bits (84),  Expect = 0.083
 Identities = 50/220 (22%), Positives = 87/220 (39%), Gaps = 26/220 (11%)

Query  360  AVMAHCKK---MQERMSAQLAAAESRQKKLEMEKLQ-------LQALEQEHKKLAARLEE  409
            A M H K+    +ER+ A       +++++  EK         +Q L    K    ++EE
Sbjct  277  AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE  336

Query  410  ERGKNKQVVLMLVKECKQLSGKVIEEAQKLED---VMAkleeekkktneleeelSAEKRR  466
               + +++     K  + L     +E Q  ED    ++  E             S E  R
Sbjct  337  LNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHR  396

Query  467  STEMEAQMEKQLSEFDTEREQLRAKLNREEAHTT---------DLKEEIDKMRKMIEQLK  517
                  ++ ++LS+   ERE+L   L  EEAH           DL+ E++K+R  + + +
Sbjct  397  LRRSIKKITQELSDLQQERERLEKDL--EEAHREKSKGDCTIRDLRNEVEKLRNEVNERE  454

Query  518  RGSDS--KPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQ  555
            +  ++  K  LS   K    +   I   TE T  + V  Q
Sbjct  455  KAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQ  494


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 44/170 (25%), Positives = 78/170 (45%), Gaps = 12/170 (7%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
            +++QER    + A+++ +   E    ++Q ++++ +K   ++E+          +L K  
Sbjct  115  RELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVED----------LLTKRI  164

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
              L   V     +LE   A  E EK     LE +LS E ++  E +  M   L E D   
Sbjct  165  LLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLS-EMKKMHEGDLAMALVLDEKDRLI  223

Query  486  EQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDR  535
            E+L+  L  +EA    LKEE  +M    E +  G + +   + PR+ K+R
Sbjct  224  EELKLSLKSKEALIQCLKEEKSQMACPDENVSSG-ELRGLCAAPREEKER  272


>gi|2833266|sp|Q15696|U2AFM_HUMAN  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit 
related-protein 2 (U2(RNU2) small nuclear RNA auxillary 
factor 1-like 2)
Length=482

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 34/173 (19%), Positives = 83/173 (47%), Gaps = 19/173 (10%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
            K   ++  A L   + ++++ E+ +L+   L Q+ ++    +EE++ + ++   +L +E 
Sbjct  12   KPSHKKYRAALKKEKRKKRRQELARLRDSGLSQKEEEEDTFIEEQQLEEEK---LLERER  68

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
            ++L  + +   QK ++     +E++           A K+R  E E ++++Q  E     
Sbjct  69   QRLHEEWLLREQKAQEEFRIKKEKE----------EAAKKRQEEQERKLKEQWEE-----  113

Query  486  EQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLV  538
             Q R +   EE    + KE+ + ++KM++Q +   ++  +   P    D R++
Sbjct  114  -QQRKEREEEEQKRQEKKEKEEALQKMLDQAENELENGTTWQNPEPPVDFRVM  165


>gi|32470611|sp|Q08379|GOGA2_HUMAN  Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) 
(Gm130 autoantigen) (Golgin-95)
Length=990

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 36/174 (20%), Positives = 79/174 (45%), Gaps = 17/174 (9%)

Query  360  AVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL  419
            A  A+ K ++ R      A +S     +   + ++ L+Q+++++  +LEEE+ +  Q   
Sbjct  139  ASSANLKDLESRYQQLAVALDSSYVTNKQLNITIEKLKQQNQEITDQLEEEKKECHQKQG  198

Query  420  MLVKECK---QLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEK  476
             L ++ +   Q  G ++ E  +L+  +A  +   ++     E+L++  + S     ++E+
Sbjct  199  ALREQLQVHIQTIGILVSEKAELQTALAHTQHAARQKEGESEDLASRLQYSRRRVGELER  258

Query  477  QLSEFDT--------------EREQLRAKLNREEAHTTDLKEEIDKMRKMIEQL  516
             LS   T              ER+ LR +L +      DLK+E  ++ + +  L
Sbjct  259  ALSAVSTQQKKADRYNKELTKERDALRLELYKNTQSNEDLKQEKSELEEKLRVL  312


>gi|12643721|sp|Q13507|TRPC3_HUMAN  Short transient receptor potential channel 3 (TrpC3) (Htrp-3) 
(Htrp3)
Length=848

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 8/85 (9%)

Query  964   AAAQGNVTLLSMLLNEEGLDINYSCED--GHSALYSAAKNGHTDCVRLLLSAEAQVNAAD  1021
             AA  GN+ ++  +L EE   +N +C D  G +AL  A  N H +   LLL  E      D
Sbjct  46    AAEYGNIPVVRKML-EESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD  104

Query  1022  KNGFTPLCAAAAQGHFECVELLISY  1046
                   L  A ++G+   VE ++++
Sbjct  105   -----ALLLAISKGYVRIVEAILNH  124


>gi|134517|sp|P12755|SKI_HUMAN  Ski oncogene (C-ski)
Length=728

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 43/186 (23%), Positives = 82/186 (44%), Gaps = 27/186 (14%)

Query  334  LQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEM----E  389
            L++  E G   KE K         L  V+    K +E++SA L A  S  ++LE     +
Sbjct  545  LRQALEGGLDTKEAKE------KFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK  598

Query  390  KLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleee  449
            K +L+   +  + L   +E  R +N+       K+ K+ +   +   ++LE        +
Sbjct  599  KEKLREATEAKRNLRKEIERLRAENE-------KKMKEANESRLRLKRELEQARQARVCD  651

Query  450  kkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKM  509
            K              + S ++E  ++ +L   + +REQLRA L RE     + +E ++K+
Sbjct  652  KGCEAGRL-----RAKYSAQIE-DLQVKLQHAEADREQLRADLLRER----EAREHLEKV  701

Query  510  RKMIEQ  515
             K +++
Sbjct  702  VKELQE  707


>gi|55976584|sp|Q9BYJ4|TRI34_HUMAN  Tripartite motif protein 34 (Interferon-responsive finger protein 
1) (RING finger protein 21)
Length=488

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 52/195 (26%), Positives = 80/195 (41%), Gaps = 40/195 (20%)

Query  343  GDKEKKPVCTNPLSILEAVMA--HCKKMQERMSAQLAAAESRQKKLEM-----EKLQLQA  395
            G K   PVC    S  E + A  H   + ER+  ++  +    KK ++     EKL L  
Sbjct  51   GGKSSCPVCGISYSF-EHLQANQHLANIVERLK-EVKLSPDNGKKRDLCDHHGEKLLLFC  108

Query  396  LEQEHKK--LAARLEEERGKNKQVVLMLVKECKQLSGKVI-------EEAQKLEDVMAkl  446
             E       L  R +E RG +  +   + KEC++    V+       EEA+KLE  +   
Sbjct  109  KEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIR--  166

Query  447  eeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI  506
                            E++ S + + Q E+Q     TE +QLR+ LN EE       EE 
Sbjct  167  ----------------EEKTSWKYQVQTERQ--RIQTEFDQLRSILNNEEQRELQRLEEE  208

Query  507  DKMRKMIEQLKRGSD  521
            +K  K +++     D
Sbjct  209  EK--KTLDKFAEAED  221


>gi|46396998|sp|Q96T51|RUFY1_HUMAN  RUN and FYVE domain-containing protein 1 (FYVE-finger protein 
EIP1) (Zinc finger FYVE domain-containing protein 12)
Length=600

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 49/257 (19%), Positives = 102/257 (39%), Gaps = 57/257 (22%)

Query  260  KKEFDVDTLSKSELRMLLSVMEGEL-EARDLVIEALRELKWFTGIKTAKWENARRKEVFI  318
            +KE ++    K+E+ + + ++E +  E +D ++   ++L+    I    +  A+  E  +
Sbjct  310  EKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL  369

Query  319  QERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAA  378
            Q                          +K    T+       VM+  K+M+ER+     A
Sbjct  370  Q--------------------------QKNEAITSFEGKTNQVMSSMKQMEERLQHSERA  403

Query  379  ---AESRQKKLEME--------KLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ  427
               AE R  KL+ E        +LQL  L ++   L   L+ E+ + +Q +   ++  K 
Sbjct  404  RQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEK-EQRQALQRELQHEKD  462

Query  428  LSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQ  487
             S  +  E Q++E +                    E R   + +A+++K   E +   ++
Sbjct  463  TSSLLRMELQQVEGL------------------KKELRELQDEKAELQKICEEQEQALQE  504

Query  488  LRAKLNREEAHTTDLKE  504
            +   L++ +    D+KE
Sbjct  505  MGLHLSQSKLKMEDIKE  521


>gi|32699565|sp|Q8IUG5|MY18B_HUMAN  Myosin-18B (Myosin XVIIIb)
Length=2567

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 52/234 (22%), Positives = 101/234 (43%), Gaps = 30/234 (12%)

Query  279   VMEGELEARDLVIEALRELKWFTGIKTAKWENARRK----EVFIQERYGRFNLNDPFLAL  334
             V+E E   R      ++ELK       +K E  ++K       ++E   +  LND    L
Sbjct  1459  VLESERAERLQAFREVQELK-------SKHEQVQKKLGDVNKQLEEAQQKIQLND----L  1507

Query  335   QRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQ  394
             +R+   GA + + +  C    +  E +    ++ +ER+ ++L A    +K+LE +  +LQ
Sbjct  1508  ERNPTGGADEWQMRFDCAQMEN--EFLRKRLQQCEERLDSELTA----RKELEQKLGELQ  1561

Query  395   ALEQEHKKLAARLEEERGKNKQVVLMLVKEC-----KQLSGKVIEEAQKLEDVMAkleee  449
             +     KK+A +L+    K   +   L   C     +Q     +E+ QK  D+       
Sbjct  1562  SAYDGAKKMAHQLKR---KCHHLTCDLEDTCVLLENQQSRNHELEKKQKKFDLQLAQALG  1618

Query  450   kkktneleeelSAEKRRSTEME-AQMEKQLSEFDTEREQLRAKLNREEAHTTDL  502
             +    +   E   ++  S   E  Q+++QL + + E  QL+ ++   + H  +L
Sbjct  1619  ESVFEKGLREKVTQENTSVRWELGQLQQQLKQKEQEASQLKQQVEMLQDHKREL  1672


>gi|20141591|sp|Q15811|ITSN1_HUMAN  Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Length=1721

 Score = 36.6 bits (83),  Expect = 0.11
 Identities = 38/183 (20%), Positives = 87/183 (47%), Gaps = 12/183 (6%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
            ++++      + ++ S  ++L  E +     +Q  KKL    E+++ +N +   + +++ 
Sbjct  309  RRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKR  368

Query  426  KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
            +Q     + E Q+ E       E  ++  +  E    E++R  E+E Q+EKQ  E + +R
Sbjct  369  RQ----ALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQ-RELERQR  423

Query  486  EQLRAK-LNREEAHTTDLKE------EIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLV  538
            E+ R K + R EA   +L+       E ++ ++++ Q  +  +    L   +KT +  L 
Sbjct  424  EEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELE  483

Query  539  SIS  541
            +++
Sbjct  484  ALN  486


>gi|134594|sp|P12757|SKIL_HUMAN  Ski-like protein (Ski-related protein) (Ski-related oncogene)
Length=684

 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 38/166 (22%), Positives = 75/166 (45%), Gaps = 28/166 (16%)

Query  357  ILEAVMAHCKKMQERMSAQLAAAESRQKKLEM--EKLQLQALEQEHKKLAARLEEERGKN  414
            I+E VM    K QE+++  L   +  Q +++M      ++ L +E + L   LE  + ++
Sbjct  530  IMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEH  589

Query  415  KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME---  471
             Q +     E K L        +KLE +M           +   + + EK +  E     
Sbjct  590  AQRMEEFYVEQKDLE-------KKLEQIM---------KQKCTCDSNLEKDKEAEYAGQL  633

Query  472  AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
            A++ ++L   + +R++L+ +L +E       +E   K+  MI++LK
Sbjct  634  AELRQRLDHAEADRQELQDELRQE-------REARQKLEMMIKELK  672


>gi|71151982|sp|Q7Z406|MYH14_HUMAN  Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin 
heavy chain IIc) (NMHC II-C)
Length=1995

 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 59/280 (21%), Positives = 116/280 (41%), Gaps = 21/280 (7%)

Query  261   KEFDVDTLSKSELRMLLSVMEGELEA-RDLVIEALRELKWFTGIKTAKWENARRKEVFIQ  319
             +E        SE R       G LEA  +    A RE +  T     K E   R E    
Sbjct  1381  RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLER--G  1438

Query  320   ERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAA  379
              R  +  L+D  + L++  +  +  ++K+      L+  +A +    + +ER  A+    
Sbjct  1439  RRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRER  1498

Query  380   ESRQ----KKLEMEKLQLQALEQEHKKLAARLE------EERGKNKQVVLMLVKECKQLS  429
             E+R     + LE E+   + LE++++ L A LE      ++ GK+   +    +  +Q +
Sbjct  1499  EARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAA  1558

Query  430   GKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRST--------EMEAQMEKQLSEF  481
               +  +  +LED +   E+ K +     + L  +  R          E   Q+ KQL + 
Sbjct  1559  NDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDA  1618

Query  482   DTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD  521
             + ER++ R +     A    L+ E+++++  +    +G +
Sbjct  1619  EVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKE  1658


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 40/154 (25%), Positives = 69/154 (44%), Gaps = 34/154 (22%)

Query  367   KMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECK  426
             ++QE+M  Q       Q++ E  + QL   E+E +   AR E+E G   Q    L+K  +
Sbjct  1083  ELQEQMVEQ-------QQRAEELRAQLGRKEEELQAALARAEDEGGARAQ----LLKSLR  1131

Query  427   QLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRR---STEMEA---QMEKQLSE  480
             +    + E  + LE              E      AEK+R     E+EA   ++E  L  
Sbjct  1132  EAQAALAEAQEDLES-------------ERVARTKAEKQRRDLGEELEALRGELEDTLDS  1178

Query  481   FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
              + ++E LR+K    E   T+LK+ +++  ++ E
Sbjct  1179  TNAQQE-LRSK---REQEVTELKKTLEEETRIHE  1208


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 40/155 (25%), Positives = 68/155 (43%), Gaps = 8/155 (5%)

Query  355   LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKN  414
             L  L+A MA   + +E    QL   +++ K+L  E  + +   +E      R  E+R K 
Sbjct  1643  LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS-QNRESEKRLKG  1701

Query  415   KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM  474
              +  ++ ++E    S +   +AQ+  D MA        +     E   EKR+      Q+
Sbjct  1702  LEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE---EKRQLEGRLGQL  1758

Query  475   EKQLSEFDTEREQL----RAKLNREEAHTTDLKEE  505
             E++L E  +  E L    R  L + E+ TT+L  E
Sbjct  1759  EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE  1793


>gi|90185247|sp|Q86W92|LIPB1_HUMAN  Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting 
protein-binding protein 1) (PTPRF-interacting 
protein-binding protein 1) (hSGT2)
Length=1011

 Score = 36.2 bits (82),  Expect = 0.14
 Identities = 44/205 (21%), Positives = 86/205 (41%), Gaps = 32/205 (15%)

Query  387  EMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkl  446
            E+  L+L+  E + ++L     E++ K+ + ++  +   K   G++  E Q++E      
Sbjct  206  EINDLRLKVSEMDSERLQY---EKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQ-----  257

Query  447  eeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEI  506
                        +  + K     ++ Q+E++ SE    +E+L  K+  E     D   E+
Sbjct  258  ------------KWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEV  305

Query  507  DKMRKMIEQLKRGSDSKP------SLSLPRKTKDRRLVSISVGTEG---TVTRSVACQTD  557
             KM+K +E L   ++ K          L R  K +  V ++ G +G    +  S +  + 
Sbjct  306  QKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSL  365

Query  558  LVTENADHMKKLPLTMPVKPSTGSP  582
            L  +    ++K P   PV    GSP
Sbjct  366  LDAQGFSDLEKSPSPTPV---MGSP  387


>gi|56405385|sp|Q9HCM9|TRI39_HUMAN  Tripartite motif protein 39 (RING finger protein 23) (Testis-abundant 
finger protein)
Length=518

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 27/83 (32%), Positives = 45/83 (54%), Gaps = 8/83 (9%)

Query  345  KEKKPVCTNPLSILEAVMAHCKKMQERMSAQL-AAAESRQKKL--EMEKLQLQALEQEHK  401
            KEK   C  PL      +  CK  +E+   +L    ESR++++  E E+L  + L++E +
Sbjct  151  KEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELH-RRLDEEQQ  209

Query  402  KLAARLEEERGKNKQVVLMLVKE  424
             L +RLEEE    +Q +L  ++E
Sbjct  210  VLLSRLEEE----EQDILQRLRE  228


>gi|74762068|sp|Q9Y5S2|MRCKB_HUMAN  Serine/threonine-protein kinase MRCK beta (CDC42-binding protein 
kinase beta) (Myotonic dystrophy kinase-related CDC42-binding 
kinase beta) (Myotonic dystrophy protein kinase-like beta) 
(MRCK beta) (DMPK-like beta)
Length=1711

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 40/178 (22%), Positives = 79/178 (44%), Gaps = 29/178 (16%)

Query  373  SAQLAAAESRQKKLEMEKLQLQALEQEHKKL------AARLEEERGKNKQVVLMLVKECK  426
            S Q+ A E R ++LE EKL+L    QE  +       ++R      ++K+ +  L +E +
Sbjct  437  SLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKE-IKKLNEEIE  495

Query  427  QLSGKVIEE---AQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDT  483
            +L  K+ +     ++LED +A               L  E+  ST+    +EKQ      
Sbjct  496  RLKNKIADSNRLERQLEDTVA---------------LRQEREDSTQRLRGLEKQHRVVRQ  540

Query  484  EREQLRAKL----NREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
            E+E+L  +L     R ++   +LK+   + +  +++    ++    L   ++   R+L
Sbjct  541  EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQL  598


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 41/180 (22%), Positives = 78/180 (43%), Gaps = 24/180 (13%)

Query  344  DKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKL  403
            DKE K +    +  L+  +A   +++ ++   +A  + R+   +    +L+ LE++H+ +
Sbjct  484  DKEIKKL-NEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQ----RLRGLEKQHRVV  538

Query  404  AARLEE------ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnele  457
                EE      E  +  +     +K+  Q     ++E  +L + MA          EL 
Sbjct  539  RQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMA----------ELR  588

Query  458  eelSAEKRRSTEMEAQMEKQLSEFDTEREQLR--AKLNRE-EAHTTDLKEEIDKMRKMIE  514
             +     R+  + E +ME    + D  R+++R   KL +E EA   D   E  K RK+ E
Sbjct  589  AQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLRE  648


>gi|20138952|sp|Q15025|NAF1_HUMAN  Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) 
(HIV-1 Nef-interacting protein) (Virion-associated nuclear 
shuttling protein) (VAN) (hVAN) (Nip40-1)
Length=636

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 34/157 (21%), Positives = 68/157 (43%), Gaps = 24/157 (15%)

Query  389  EKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAklee  448
            E + L A E++ K L  +  E    NKQ         +Q   K+ E  QKL D+      
Sbjct  292  EVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADL------  345

Query  449  ekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDK  508
                           +++ T++EA+ E++  +FD +    ++K+  EE     L  E  +
Sbjct  346  ---------------QKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKE  390

Query  509  MRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTE  545
            +R+ ++ L+   D    L+  R+ +++ +  ++   E
Sbjct  391  LRQKVKYLQ---DQLSPLTRQREYQEKEIQRLNKALE  424


>gi|13124651|sp|Q9NX95|K1472_HUMAN  Protein KIAA1472
Length=595

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 37/158 (23%), Positives = 68/158 (43%), Gaps = 12/158 (7%)

Query  473  QMEKQLSEFDTEREQLRAKLNR-------EEAHTTDLKEEIDKMRKMIEQLKRGSDSKPS  525
            + E++L E ++E  +L+++L R       EE H  + +  + + RK I+QLK+  ++  S
Sbjct  219  ESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRS  278

Query  526  LSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENA---DHMKKLPLTMPVKPSTGSP  582
             SL  K K  +   + +  +     S+    ++    +   +     P   P K  T +P
Sbjct  279  -SLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNP  337

Query  583  LVSANAKGSVCTSATMARPGIDRQASYGDLIGASVPAF  620
             +   A G +     +   G DR+   GD I  S   F
Sbjct  338  PLDTMADG-LSLEEQVTGEGADRELLVGDSIANSTGLF  374


>gi|62286928|sp|Q7Z6B0|GGABP_HUMAN  GGA-binding partner (p56 accessory protein)
Length=441

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 52/196 (26%), Positives = 97/196 (49%), Gaps = 14/196 (7%)

Query  337  DYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQ---LAAAESRQKKLEMEKLQL  393
            +Y+A      K+ V       + A+     K +E ++AQ   L      +K+L  EK++ 
Sbjct  216  EYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKE  275

Query  394  QALEQ--EHKKLAAR-LEEERGKNKQVVLMLVK----ECKQLSGKVIEEAQK-LEDVMA-  444
              ++Q  E K++  + LEEER +NK+ ++   K      K    KV+EE +K LE   A 
Sbjct  276  ALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAMKDAVLKVVEEERKNLEKAHAE  335

Query  445  kleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEA--HTTDL  502
            + E  K +  + +E++S E +++ + + ++ ++  +     EQ R++   EEA   T D 
Sbjct  336  ERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDE  395

Query  503  KEEIDKMRKMIEQLKR  518
              E  K +K ++Q+ R
Sbjct  396  LIEYIKEQKRLDQVIR  411


>gi|34098604|sp|Q8TD16|BICD2_HUMAN  Cytoskeleton-like bicaudal D protein homolog 2
Length=824

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 64/289 (22%), Positives = 120/289 (41%), Gaps = 41/289 (14%)

Query  230  KEPAPAVREASPSW-RSVVRWPTPSMIIISRKK----EFDVDTLS-KSELRMLLSVMEGE  283
            +E A  V EA P W R+ V+  +  +   +R+K    E+ +  L  K +L++    +E +
Sbjct  8    EEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVD  67

Query  284  LEARDLVIEALREL--KWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAG  341
             EA    +E L+E   +  T  K    +   R+E  IQE            A +  Y   
Sbjct  68   YEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQES-----------ASKEQYYV-  115

Query  342  AGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHK  401
                 K       L  L  V+ + +   ER+++     +   + +E+++ +L+   +E+K
Sbjct  116  ----RKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYK  171

Query  402  KLAARLEEERGKNKQVVLMLVKECKQLSGKVIE------EAQKLEDVMAkleeekkktne  455
               ARL ++  + ++  + L K+   L    +E      E ++LE+    L  + +    
Sbjct  172  FREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAI-  230

Query  456  leeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKE  504
                     R     E Q+E+ L    TEREQ +  L +E +H   + +
Sbjct  231  ---------RLKEISERQLEEALETLKTEREQ-KNSLRKELSHYMSIND  269


>gi|3041707|sp|P13535|MYH8_HUMAN  Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)
Length=1937

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 43/165 (26%), Positives = 75/165 (45%), Gaps = 10/165 (6%)

Query  376   LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL---MLVKECKQLSGKV  432
             LA AE R ++L   K+QL+A   + K++  R EEE   N ++      L  EC +L    
Sbjct  901   LADAEERCEQLIKNKIQLEA---KIKEVTERAEEEEEINAELTAKKRKLEDECSELK---  954

Query  433   IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKL  492
              ++   LE  +AK+E+EK  T    + L+ E     E  A++ K+        +Q    L
Sbjct  955   -KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL  1013

Query  493   NREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
               EE     L +   K+ + ++ L+   + +  L +  +   R+L
Sbjct  1014  QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKL  1058


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 38/182 (20%), Positives = 85/182 (46%), Gaps = 14/182 (7%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             K +QE     L   ++ + K+ +       LEQ+   L   LE+E    K++ + L +  
Sbjct  1000  KALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE----KKLRMDLERAK  1055

Query  426   KQLSG--KVIEEA--------QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQME  475
             ++L G  K+ +E+        Q+L++ + K E E        E+  A + +  +   +++
Sbjct  1056  RKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQ  1115

Query  476   KQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDR  535
              ++ E   E E  RA   + E   +DL  E++++ + +E+    + ++  L+  R+ + +
Sbjct  1116  ARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQ  1175

Query  536   RL  537
             +L
Sbjct  1176  KL  1177


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 33/150 (22%), Positives = 66/150 (44%), Gaps = 16/150 (10%)

Query  367   KMQERMSAQLAAAESRQKKLEMEKLQ-LQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             ++Q  +S   +     + K E + +Q  + LE+  KKLA RL+E     ++ V  +  +C
Sbjct  1359  ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA----EEHVEAVNAKC  1414

Query  426   KQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER  485
               L         ++ED+M              E  +A      + +   +K LSE+  + 
Sbjct  1415  ASLEKTKQRLQNEVEDLM-----------LDVERSNAACAALDKKQRNFDKVLSEWKQKY  1463

Query  486   EQLRAKLNREEAHTTDLKEEIDKMRKMIEQ  515
             E+ +A+L   +  +  L  E+ K++ + E+
Sbjct  1464  EETQAELEASQKESRSLSTELFKVKNVYEE  1493


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 35/150 (23%), Positives = 75/150 (50%), Gaps = 10/150 (6%)

Query  370   ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS  429
             + ++ ++A  +    KL  EK   +AL++ H++    L+ E  K    V +L K   +L 
Sbjct  979   KNLTEEMAGLDETIAKLSKEK---KALQETHQQTLDDLQAEEDK----VNILTKAKTKLE  1031

Query  430   GKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME---AQMEKQLSEFDTERE  486
              +V +    LE       + ++   +LE +L   +  + +ME    Q++++L + + E  
Sbjct  1032  QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEIS  1091

Query  487   QLRAKLNREEAHTTDLKEEIDKMRKMIEQL  516
              L +K+  E+A    L+++I +++  IE+L
Sbjct  1092  NLISKIEDEQAVEIQLQKKIKELQARIEEL  1121


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 55/272 (20%), Positives = 111/272 (40%), Gaps = 25/272 (9%)

Query  259   RKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFI  318
             RK E D+    +S + M     E + +  D   E L + ++      +K E+ +  E+ +
Sbjct  1056  RKLEGDLKLAQESTMDM-----ENDKQQLD---EKLEKKEFEISNLISKIEDEQAVEIQL  1107

Query  319   QERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQERMSAQLA  377
             Q++     L      L  + EA    + K     + LS  LE +    ++     SAQ+ 
Sbjct  1108  QKKIKE--LQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVE  1165

Query  378   AAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQ  437
               + R+ + +  +  L+    +H+ + A L ++   +       + E  +    +    Q
Sbjct  1166  LNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADS-------MAELGEQIDNLQRVKQ  1218

Query  438   KLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQ-------LRA  490
             KLE   ++L+ E    +   E +S  K    +M   +E Q+SE  T+ E+       L A
Sbjct  1219  KLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTA  1278

Query  491   KLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS  522
             +  R +    +   ++D+   ++ QL R   +
Sbjct  1279  QRARLQTEAGEYSRQLDEKDALVSQLSRSKQA  1310


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 41/170 (24%), Positives = 68/170 (40%), Gaps = 21/170 (12%)

Query  353   NPLSILEAVMAHCK---KMQERMSAQLAAAESRQKKLEMEKLQLQA-LEQEHKKLAARLE  408
             N   IL+    H     + QE +  QLA  E R   L+ E  +L A LEQ  +      +
Sbjct  1648  NTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQ  1707

Query  409   EERGKNKQVVLM------LVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSA  462
             E    +++V L+      L+   K+L   V +   ++E+V+           E       
Sbjct  1708  ELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI----------QESRNAEEK  1757

Query  463   EKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKM  512
              K+  T+     E+   E DT     R K N E+    DL+  +D+  ++
Sbjct  1758  AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT-VKDLQHRLDEAEQL  1806


>gi|62901469|sp|Q9H1D0|TRPV6_HUMAN  Transient receptor potential cation channel subfamily V member 
6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium 
transport protein 1) (CaT1) (CaT-like) (CaT-L)
Length=725

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 42/148 (28%), Positives = 56/148 (37%), Gaps = 24/148 (16%)

Query  990   DGHSALYSAAKNGHTDCVRLLLSAEAQVNAADKN-------------GFTPLCAAAAQGH  1036
             +G +AL+ A  N + + VR LL+  A V+A                 G  PL  AA    
Sbjct  116   EGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNS  175

Query  1037  FECVELLISYDANINHAADGGQTPLYLACKNGNK----ECIKLLLEAGTNRS-------V  1085
              E V LLI + A+I      G T L++     NK    +   LLL    +         V
Sbjct  176   EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLV  235

Query  1086  KTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
                 G TP   A   GN    + LM  R
Sbjct  236   PNHQGLTPFKLAGVEGNTVMFQHLMQKR  263


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 24/94 (25%), Positives = 44/94 (46%), Gaps = 6/94 (6%)

Query  1026  TPLCAAAAQGHFECVELLISY-DANINHAADGGQTPLYLACKNGNKECIKLLLEAGTN--  1082
             +PL  AA     + +  L+ Y D  ++     G+T L++A    N E   +L+EA     
Sbjct  47    SPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV  106

Query  1083  ---RSVKTTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
                 + +  +G T +H AV   N++ ++ L+  R
Sbjct  107   FEPMTSELYEGQTALHIAVVNQNMNLVRALLARR  140


>gi|127234|sp|P26038|MOES_HUMAN  Moesin (Membrane-organizing extension spike protein)
Length=577

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 35/175 (20%), Positives = 89/175 (50%), Gaps = 9/175 (5%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARL---EEERGKN  414
            ++ + A  ++ + +   + A  E+ +KK EM + + + +E+E ++L  RL   EE+  K 
Sbjct  302  VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA  361

Query  415  KQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM  474
            +Q +    +   +L  +  + AQ   + +AK  +E ++  E   + S +++++ E   Q+
Sbjct  362  QQELEEQTRRALELE-QERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQE---QL  417

Query  475  EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLP  529
              +++E      QL     ++E+   + +++   +++ +E  K  ++ K ++S P
Sbjct  418  ALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLE--KTRAELKTAMSTP  470


>gi|13431939|sp|Q9Y6A5|TACC3_HUMAN  Transforming acidic coiled-coil-containing protein 3 (ERIC-1)
Length=838

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 28/130 (21%), Positives = 63/130 (48%), Gaps = 32/130 (24%)

Query  393  LQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkk  452
            ++A ++E+++L +R EE  GKN ++   ++   +++  + +EE QK +++          
Sbjct  648  VKATQEENRELRSRCEELHGKNLELG-KIMDRFEEVVYQAMEEVQKQKELS---------  697

Query  453  tneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKM  512
                              +A+++K L E    ++QL   LN  E   +DL +  +K +++
Sbjct  698  ------------------KAEIQKVLKE----KDQLTTDLNSMEKSFSDLFKRFEKQKEV  735

Query  513  IEQLKRGSDS  522
            IE  ++  +S
Sbjct  736  IEGYRKNEES  745


>gi|14195666|sp|O60841|IF2P_HUMAN  Eukaryotic translation initiation factor 5B (eIF-5B) (Translation 
initiation factor IF-2)
Length=1220

 Score = 35.8 bits (81),  Expect = 0.19
 Identities = 27/77 (35%), Positives = 46/77 (59%), Gaps = 3/77 (3%)

Query  363  AHCKKMQERMSAQLAAAESRQKKLEMEKL-QLQALEQEHKKLAARLEEERGKNKQVVLML  421
            A  K MQE + A+L   E RQK+ E E++ +L+ LE + K+   RLE+E+ + K+     
Sbjct  339  ATVKAMQEAL-AKLKEEEERQKREEEERIKRLEELEAKRKE-EERLEQEKRERKKQKEKE  396

Query  422  VKECKQLSGKVIEEAQK  438
             KE  +  GK++ ++Q+
Sbjct  397  RKERLKKEGKLLTKSQR  413


>gi|47605963|sp|O75116|ROCK2_HUMAN  Rho-associated protein kinase 2 (Rho-associated, coiled-coil-containing 
protein kinase 2) (p164 ROCK-2) (Rho kinase 2)
Length=1388

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 55/237 (23%), Positives = 112/237 (47%), Gaps = 31/237 (13%)

Query  356  SILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNK  415
            SI EA     K+M++++       E R  K ++E L L+A E+    L   L++ + K  
Sbjct  724  SIEEAKSEAMKEMEKKL------LEERTLKQKVENLLLEA-EKRCSLLDCDLKQSQQKIN  776

Query  416  QVVL---MLVKECKQLSGKVIEEAQK---LEDVMAkleeekkktneleeelSAEKRRSTE  469
            +++    +L ++ + L+ K+ +E QK    ++ +    ++       E++L  E     E
Sbjct  777  ELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLME  836

Query  470  MEAQMEKQLSEFDTERE-------QLRAKLNREEAHTT-------DLKEEIDKMRKMIEQ  515
            M+  +EKQ +E   ER+       +L+ +L  E+  +T       +LKEE ++  K+ ++
Sbjct  837  MKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKE  896

Query  516  LKRGSDSKPSLSLPRKTKDRRL-VSISVGTEGTVTRSVACQTDLVTENADHMKKLPL  571
            L++    K  L   R +   +L ++++      + RS+A +     E    MK+L +
Sbjct  897  LQQ---KKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEI  950


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 42/193 (21%), Positives = 81/193 (41%), Gaps = 31/193 (16%)

Query  271   SELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWEN--ARRKEVFIQERYGRFNLN  328
             ++L + L+  + E  AR +  E   +L+    +K  + +   AR K+   ++     +L 
Sbjct  913   AQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLE  972

Query  329   DPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEM  388
             +    L  D    A +KE+     N L  ++  ++  K   E +SA    A+  ++ L  
Sbjct  973   ETNRTLTSDVANLANEKEE---LNNKLKDVQEQLSRLK--DEEISAAAIKAQFEKQLLTE  1027

Query  389   EKLQLQAL------------------------EQEHKKLAARLEEERGKNKQVVLMLVKE  424
               L+ QA+                        E+E++KL   L+ ER K  Q ++   KE
Sbjct  1028  RTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKE  1087

Query  425   CKQLSGKVIEEAQ  437
               ++  ++ EE+Q
Sbjct  1088  LNEMQAQIAEESQ  1100


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 24/122 (19%), Positives = 54/122 (44%), Gaps = 20/122 (16%)

Query  398  QEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktnele  457
            QE +K    LEE      Q    L ++CK ++ ++ + A++LE+ +              
Sbjct  443  QEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITL------------  490

Query  458  eelSAEKRRSTEME-AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQL  516
                   R+S E    Q+E++ +    +  + + K + E     +L+ +++ ++  +E L
Sbjct  491  -------RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDL  543

Query  517  KR  518
            K+
Sbjct  544  KK  545


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 55/275 (20%), Positives = 110/275 (40%), Gaps = 17/275 (6%)

Query  259   RKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFI  318
             RK+  D D     +++ L   +E E     L    +RELK     KT   +  ++K+  +
Sbjct  849   RKERQDAD----GQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQEL  904

Query  319   QERYGRFNLNDPFLALQRDYEAGA--------GDKEKKPVCTNPLSILEAVMAHCKKMQE  370
             Q+              + D E  A         D EK+ +    L I E +  H +++ E
Sbjct  905   QDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKE-LEIKEMMARHKQELTE  963

Query  371   RMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSG  430
             +  A +A+ E   + L  +   L   ++E       ++E+  + K   +       Q   
Sbjct  964   K-DATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEK  1022

Query  431   KVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRA  490
             +++ E       + KL E   +   ++     + RR    E +  K   E  +ERE+L  
Sbjct  1023  QLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRK---EKENRKLHMELKSEREKLTQ  1079

Query  491   KLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPS  525
             ++ + +    +++ +I +  ++  +L+   DSK S
Sbjct  1080  QMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDS  1114


>gi|25009267|sp|Q9H078|CLPB_HUMAN  Caseinolytic peptidase B protein homolog (Suppressor of potassium 
transport defect 3)
Length=707

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 24/67 (35%), Positives = 36/67 (53%), Gaps = 1/67 (1%)

Query  955   AGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAE  1014
             + +   L +AA   N+  +S LL+E G D+N     G +AL  AA N +   V++LL+A 
Sbjct  132   SNKDAALLEAARANNMQEVSRLLSE-GADVNAKHRLGWTALMVAAINRNNSVVQVLLAAG  190

Query  1015  AQVNAAD  1021
             A  N  D
Sbjct  191   ADPNLGD  197


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 47/184 (25%), Positives = 73/184 (39%), Gaps = 24/184 (13%)

Query  932   LVTASGWSPSLTPLLMSGGPAPLAGR-----PTLLQQAAAQGNVTLLSMLLNEEGLDINY  986
             L  A+G  P  +P L SG  A   GR      T    AA  G +          G +   
Sbjct  48    LRVATGGRPGTSPALFSGRGAATGGRQGGRFDTKCLAAATWGRL---------PGPEETL  98

Query  987   SCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAADK---NGFTPLCAAAAQGHFECVELL  1043
               +D  + + S A  G        L+A   V+   K   N    L  AA   + + V  L
Sbjct  99    PGQDSWNGVPSRAGLG-----MCALAAALVVHCYSKSPSNKDAALLEAARANNMQEVSRL  153

Query  1044  ISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNV  1103
             +S  A++N     G T L +A  N N   +++LL AG + ++   D ++ V+       +
Sbjct  154   LSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNL--GDDFSSVYKTAKEQGI  211

Query  1104  DSLK  1107
              SL+
Sbjct  212   HSLE  215


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 4/100 (4%)

Query  993   SALYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH  1052
             +AL  AA+  +   V  LLS  A VNA  + G+T L  AA   +   V++L++  A+ N 
Sbjct  136   AALLEAARANNMQEVSRLLSEGADVNAKHRLGWTALMVAAINRNNSVVQVLLAAGADPNL  195

Query  1053  AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWT  1092
               D   + +Y   K      ++   + G +R +  T+ WT
Sbjct  196   GDD--FSSVYKTAKEQGIHSLEDGGQDGASRHI--TNQWT  231


>gi|84027766|sp|Q5VTR2|BRE1A_HUMAN  Ubiquitin-protein ligase BRE1A (BRE1-A) (RING finger protein 
20)
Length=975

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 60/272 (22%), Positives = 121/272 (44%), Gaps = 31/272 (11%)

Query  257  ISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEV  316
            +S  +E D+ TL +++ R L  +++      D + E + +L+       A         +
Sbjct  40   VSSTEELDIRTL-QTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASL-------L  91

Query  317  FIQERYGRFNLNDPFLALQRDYEAGAGD---KEKKPVCTNPLSILEAVMAHCKKMQERMS  373
             +   + +F+ N   +  + D E G GD   + K  V   P    ++     K  +ER  
Sbjct  92   IVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQER-KDDRERGE  150

Query  374  AQ------LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ  427
             Q      LA   S   + EME  QLQ   +  ++  +++     K ++ V +L ++   
Sbjct  151  GQEPAFSFLATLASSSSE-EMES-QLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNS  208

Query  428  LSGKVIEEA-QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTERE  486
                ++EEA Q+L   +A+     ++  +L +    EK R+      M ++ S+  ++ E
Sbjct  209  GDNLIVEEAVQELNSFLAQENMRLQELTDLLQ----EKHRT------MSQEFSKLQSKVE  258

Query  487  QLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
               ++++  E+   DL+ +IDK+RK  ++L R
Sbjct  259  TAESRVSVLESMIDDLQWDIDKIRKREQRLNR  290


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 30/162 (18%), Positives = 84/162 (51%), Gaps = 7/162 (4%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKN---KQVVLMLV  422
            ++ +ER   +      R+K+ E E+ + Q L++  K+  +  ++E+GK+   ++    ++
Sbjct  568  ERERERREKEREREREREKEKERER-EKQKLKESEKERDSAKDKEKGKHDDGRKKEAEII  626

Query  423  KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFD  482
            K+ K    K  E  ++++ ++       K+  +  + ++AEK+   E+E  + ++L + +
Sbjct  627  KQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELE-DLRQRLKDLE  685

Query  483  TEREQLRAKLNREEA--HTTDLKEEIDKMRKMIEQLKRGSDS  522
             + ++   K+  E+A      ++E+I+ ++K +   K+  ++
Sbjct  686  DKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEA  727


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 18/66 (27%), Positives = 37/66 (56%), Gaps = 1/66 (1%)

Query  463  EKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS  522
            E+ R  E E + EKQ  + ++E+E+  AK   +  H    K+E + ++++  +LK+  +S
Sbjct  581  EREREKEKEREREKQKLK-ESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES  639

Query  523  KPSLSL  528
            +  + L
Sbjct  640  QKEMKL  645


>gi|12644130|sp|P15924|DESP_HUMAN  Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Length=2871

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 33/142 (23%), Positives = 70/142 (49%), Gaps = 11/142 (7%)

Query  380   ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEE----  435
             E    + E+EK Q QALE  +     R++E + +  QVV    +E   +  KV+E+    
Sbjct  1776  ERENLRQEIEKFQKQALEASN-----RIQESKNQCTQVV--QERESLLVKIKVLEQDKAR  1828

Query  436   AQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNRE  495
              Q+LED + + +   +    +++ L  EK++      Q + Q S  +    ++ ++  + 
Sbjct  1829  LQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKS  1888

Query  496   EAHTTDLKEEIDKMRKMIEQLK  517
             E     L+ EI++++  I++++
Sbjct  1889  EREKNSLRSEIERLQAEIKRIE  1910


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 53/254 (20%), Positives = 99/254 (38%), Gaps = 31/254 (12%)

Query  309   ENARRKEVFIQERYGRFNLNDPFLALQR-DYEAGAGDKEKKPVCTNPLSILEAVMAHCKK  367
             E  R K++  +E   R  L D    LQR  Y+    +        N L + E  +   + 
Sbjct  1482  EIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETI-NKLKVQEQELTRLRI  1540

Query  368   MQERMSAQLAAAESR----QKKLEMEKLQLQALEQE--------------HKKLAARLEE  409
               ER+S +    +      Q  L+  +LQ Q +E+E               KKL   LE 
Sbjct  1541  DYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEG  1600

Query  410   ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTE  469
              R   K+  + +    +QL    I + +  +D+  + +       E +      +R S+E
Sbjct  1601  MRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSE  1660

Query  470   MEA------QMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
             +EA      Q ++ + +     E  +  +  +     + K EI++++ + E L     +K
Sbjct  1661  VEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL-----TK  1715

Query  524   PSLSLPRKTKDRRL  537
               L L  + ++ RL
Sbjct  1716  EHLMLEEELRNLRL  1729


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 49/221 (22%), Positives = 91/221 (41%), Gaps = 50/221 (22%)

Query  324   RFNLNDPFLALQRD-YEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQE------------  370
             R NL       Q+   EA    +E K  CT  +   E+++   K +++            
Sbjct  1777  RENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDEL  1836

Query  371   -RMSAQLAAAESRQKKLEMEKLQLQ------ALEQEHKKLAAR-LEEERGKNKQVVLMLV  422
              R  + L A    +++LE EK Q+Q        +   K+ A R +E ER K+++    L 
Sbjct  1837  NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLR  1896

Query  423   KECKQLSGKV--IEE--AQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQL  478
              E ++L  ++  IEE   +KLED                         + E ++Q+E + 
Sbjct  1897  SEIERLQAEIKRIEERCRRKLED------------------------STRETQSQLETER  1932

Query  479   SEFDTEREQLRAKLNREEAHT-TDLKEEIDKMRKMIEQLKR  518
             S +  E ++LR +       T T+ +  +D  + + + L++
Sbjct  1933  SRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRK  1973


>gi|62901471|sp|Q9NQA5|TRPV5_HUMAN  Transient receptor potential cation channel subfamily V member 
5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial 
calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 
2) (CaT2)
Length=729

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 43/147 (29%), Positives = 58/147 (39%), Gaps = 24/147 (16%)

Query  991   GHSALYSAAKNGHTDCVRLLLSAEAQVNA---------ADKN----GFTPLCAAAAQGHF  1037
             G +AL+ A  N + + VR LL+  A V+A         + +N    G  PL  AA     
Sbjct  117   GQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSE  176

Query  1038  ECVELLISYDANINHAADGGQTPLYLACKNGNK----ECIKLLLEAGTNRS-------VK  1086
             E V LLI + A+I      G T L++     NK    +   LLL    +         V 
Sbjct  177   EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVP  236

Query  1087  TTDGWTPVHAAVDTGNVDSLKLLMYHR  1113
                G TP   A   GN    + LM  R
Sbjct  237   NHQGLTPFKLAGVEGNTVMFQHLMQKR  263


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 6/94 (6%)

Query  1026  TPLCAAAAQGHFECV-ELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAGTNRS  1084
             +PL  A+ +     + +LL+    ++      G+T L++A    N E   +L+EA     
Sbjct  47    SPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELV  106

Query  1085  VKTTD-----GWTPVHAAVDTGNVDSLKLLMYHR  1113
              + T      G T +H AV   NV+ ++ L+  R
Sbjct  107   FEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRR  140


>gi|586120|sp|Q07283|TRHY_HUMAN  Trichohyalin
Length=1898

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 36/154 (23%), Positives = 72/154 (46%), Gaps = 4/154 (2%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQL  428
            QER   QL   +  +++    KL+ +   ++ ++   +L  E+ + ++  L   +E ++L
Sbjct  488  QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL  547

Query  429  SGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQL  488
              ++  E Q   +   +LE+  K+  E   E    ++R    + +   QL + + ER Q 
Sbjct  548  QQRLRSEQQLRREQEERLEQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ  607

Query  489  RAKLNREEAHTTDLK----EEIDKMRKMIEQLKR  518
            R K  +EE     LK    E +++  +  E+LKR
Sbjct  608  RLKREQEERLEQRLKREEVERLEQEERRDERLKR  641


 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 51/259 (19%), Positives = 113/259 (43%), Gaps = 11/259 (4%)

Query  283  ELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGA  342
            E E R    E L+  K     +    E  RR+E+    R GR          +R+ +   
Sbjct  182  EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQ----RRERQDRV  237

Query  343  GDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKK  402
              +E++       ++L       ++ + +   +L   E + +KLE ++L+ +  E+E ++
Sbjct  238  FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ  297

Query  403  LAARLEEE-RGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelS  461
               R E++ R K ++      +E ++   +  ++ ++ E  + + +EE+++     E   
Sbjct  298  QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE--Q  355

Query  462  AEKRRSTEMEAQMEKQLSEFDTEREQLRAK----LNREEAHTTDLKEEIDKMRKMIEQLK  517
             E+RR  ++  + E++  E    REQ   +    L RE+    + +   ++  +  +QL+
Sbjct  356  EEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLR  415

Query  518  RGSDSKPSLSLPRKTKDRR  536
            R    +    L R+ + RR
Sbjct  416  REQQLRREQQLRREQQLRR  434


 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 40/158 (25%), Positives = 79/158 (50%), Gaps = 14/158 (8%)

Query  366  KKMQERMSAQLAAAESRQKKLE--MEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVK  423
            +++Q+R+ ++      ++++LE  +++ + + LEQE ++   RL+ E+ + +  +L   +
Sbjct  545  ERLQQRLRSEQQLRREQEERLEQLLKREEEKRLEQERRE--QRLKREQEERRDQLLKREE  602

Query  424  ECKQLSGK-----VIEEAQKLEDVMAkleeekkktneleeelSAEKR----RSTEMEAQM  474
            E +Q   K      +E+  K E+V    +EE++      EE   E+R    +S E E + 
Sbjct  603  ERRQQRLKREQEERLEQRLKREEVERLEQEERRDERLKREEPEEERRHELLKSEEQEERR  662

Query  475  EKQLSEFDTEREQLRAKLNREEAHTTD-LKEEIDKMRK  511
             +QL     ER + R K   EE      LK E ++ R+
Sbjct  663  HEQLRREQQERREQRLKREEEEERLEQRLKREHEEERR  700


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 38/159 (23%), Positives = 75/159 (47%), Gaps = 24/159 (15%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQAL----EQEHKKLAARLEEERGKNKQVVLMLVKE  424
            ++R+SA+    E R+++L  E+ Q +      E+E K+   R   ER K     L  ++E
Sbjct  799  RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRGRQRREREKE----LQFLEE  854

Query  425  CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
             +QL  +  E AQ+L++               E+ L  ++ R  + + + +K   + + E
Sbjct  855  EEQLQRR--ERAQQLQE--------------EEDGLQEDQERRRQEQRRDQKWRWQLEEE  898

Query  485  REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
            R++ R  L  + A    L++E   +++  E+L+R    K
Sbjct  899  RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK  937


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 38/174 (21%), Positives = 79/174 (45%), Gaps = 5/174 (2%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
            ++ Q R   QL   +  +++ ++ + Q    EQE ++   + E+ER + +   L   +E 
Sbjct  416  REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR---LKREQEE  472

Query  426  KQLSGKVIEEAQKLE-DVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
            ++   K  EE ++ E +   +  +  ++    E  L  E+    E + + E+QL     E
Sbjct  473  RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE  532

Query  485  REQLRAKLNREEAHTTD-LKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
            R + R K   EE      L+ E    R+  E+L++    +    L ++ +++RL
Sbjct  533  RREQRLKRQEEEERLQQRLRSEQQLRREQEERLEQLLKREEEKRLEQERREQRL  586


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 45/193 (23%), Positives = 78/193 (40%), Gaps = 30/193 (15%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQL--------QALEQEHKKLAARLEE  409
             LE      ++ Q+ +   L   + R ++ E  + Q         + LE+E +K A R + 
Sbjct  1211  LEDSQVRDRQSQQDLQHLLGEQQERDREQERRRWQQANRHFPEEEQLEREEQKEAKRRDR  1270

Query  410   ERGKNKQVVLMLVKECK---QLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRR  466
             +  + KQ++    +E +   +   K  EE Q L++             E         R+
Sbjct  1271  KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE-----------REEQPLLRQERDRK  1319

Query  467   STEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK---  523
               E E   ++Q  +F  E ++LR     EE     LKEE     +  EQL++  D K   
Sbjct  1320  FREEELLHQEQGRKFLEEEQRLR-----EERERKFLKEEQQLRLEEREQLRQDRDRKFRE  1374

Query  524   PSLSLPRKTKDRR  536
                 L R+ +DR+
Sbjct  1375  EEQQLSRQERDRK  1387


>gi|12643718|sp|Q13439|GOGA4_HUMAN  Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) 
(Golgin-245) (Protein 72.1)
Length=2230

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 43/178 (24%), Positives = 80/178 (44%), Gaps = 26/178 (14%)

Query  369  QERMSAQLAAAESRQKKLEMEKL----QLQALEQEHKKLAARLEEERGKNKQV-------  417
            +ER+S Q   +  +Q+ +++ K     Q+  L++ H+K  AR E+E  K  Q        
Sbjct  450  EERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQE  509

Query  418  ------------VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKR  465
                         L + +E +Q     +EE +  +   A L E + K  +L++E    + 
Sbjct  510  QMKVALEKSQSEYLKISQEKEQQESLALEELELQKK--AILTESENKLRDLQQEAETYRT  567

Query  466  RSTEMEAQMEKQLSEFDTEREQLRAKLNREE-AHTTDLKEEIDKMRKMIEQLKRGSDS  522
            R  E+E+ +EK L E   + + L   L  E+  H  ++   ++K +  +E LK   D+
Sbjct  568  RILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA  625


 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 62/279 (22%), Positives = 118/279 (42%), Gaps = 36/279 (12%)

Query  257  ISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEV  316
            +SR K+  VD + KS    +  + +  L  ++L   A +E +    ++T + E   + +V
Sbjct  459  LSRVKQEVVDVMKKSSEEQIAKLQK--LHEKEL---ARKEQELTKKLQTREREFQEQMKV  513

Query  317  FIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQL  376
             +++    +         Q        + +KK + T   + L  +    +  + R+   L
Sbjct  514  ALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRI---L  570

Query  377  AAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGK-NKQVVLMLVKECKQLSG-KVIE  434
                S +K L+  K Q        K LA  LE E+ K NK++ +M+ K   +L   K  +
Sbjct  571  ELESSLEKSLQENKNQ-------SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQ  623

Query  435  EAQKLEDVMAkleeekkktneleeelSAEKRR---------STEMEAQMEKQLSEFD---  482
            +A   E +    ++ + +  +L E+   EK              +E   EK L + D   
Sbjct  624  DALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQ  683

Query  483  TEREQLRAKLN-------REEAHTTDLKEEIDKMRKMIE  514
            TE E L ++L+       + E   + LK++ DKM++ +E
Sbjct  684  TELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE  722


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 50/240 (20%), Positives = 104/240 (43%), Gaps = 36/240 (15%)

Query  355  LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKN  414
            L  L+      + +   +S  L A    +++L + K Q   ++QE   L A+++E++  +
Sbjct  676  LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE---LEAKMDEQKNHH  732

Query  415  KQVVLMLVKECK---QLSGKVI-EEAQKLEDVMAkleeekkktneleeelSAEKRRST--  468
            +Q V  ++KE +   Q + K + ++  +LE ++ + ++  K+     E L A+ +RS   
Sbjct  733  QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE  792

Query  469  --------------------------EMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDL  502
                                      E  AQ++++L + +TER  L  ++   EA   D+
Sbjct  793  LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDV  852

Query  503  KEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTEN  562
              E+D  +  ++ L +  + K +  + +K K    V  S   +G   +    Q  +  EN
Sbjct  853  CTELDAHKIQVQDLMQQLE-KQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN  911


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 36/167 (21%), Positives = 70/167 (41%), Gaps = 42/167 (25%)

Query  368   MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQ  427
             ++ ++ +  A  E+++K+LE   L +++ E+E K L  RLE E                 
Sbjct  1590  LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESES----------------  1633

Query  428   LSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQ  487
              + K+ E  +K E  +A                + +K+  ++ME + E+     ++   +
Sbjct  1634  -AAKLAELKRKAEQKIA----------------AIKKQLLSQMEEKEEQYKKGTESHLSE  1676

Query  488   LRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
             L  KL   E     L+E++    K +E     S    +L +PR  K+
Sbjct  1677  LNTKLQEREREVHILEEKL----KSVE-----SSQSETLIVPRSAKN  1714


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 50/233 (21%), Positives = 102/233 (43%), Gaps = 30/233 (12%)

Query  368  MQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG--------KNKQVVL  419
            +QE++  +L   E  +     EK +L    ++ K L  +LE+++G        +  + + 
Sbjct  319  LQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE  378

Query  420  MLVKECKQLSGKVIE--------EAQKLEDVMAkleeekkktneleeelSAEKRRSTEME  471
            M  +E  QL  ++ +          QK +   A  EE +K  +  ++   A ++   EM+
Sbjct  379  MKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMD  438

Query  472  AQMEKQLSEFDTEREQLRAKLNREEAHTTDL-----KEEIDKMRKMIEQLKRGSDSKPSL  526
             Q++      + ER  L+ +L+R +    D+     +E+I K++K+ E  K  +  +  L
Sbjct  439  EQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE--KELARKEQEL  496

Query  527  SLPRKTKDRRL-VSISVGTEGT------VTRSVACQTDLVTENADHMKKLPLT  572
            +   +T++R     + V  E +      +++    Q  L  E  +  KK  LT
Sbjct  497  TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILT  549


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 37/190 (19%), Positives = 88/190 (46%), Gaps = 29/190 (15%)

Query  355   LSILEAVMAHCKKMQERMSAQLAAAESRQKKLEME------KLQ-LQALEQEHKKLAARL  407
             +S+L+  +   +K+ +R+  +     S   ++  +      KL+  +A + E + +   L
Sbjct  1738  ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHL  1797

Query  408   EEE-RGKNKQVVLMLVKECKQLSGKV-IEEAQKLEDVMAkleeekkktneleeelSAEKR  465
             +EE   KNK+  L++ +  ++  GK  I+  Q LE+V   +++  +           EK 
Sbjct  1798  QEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ-----------EKE  1846

Query  466   RSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPS  525
              + ++   +E+++ E D+        + ++E H  +++E   K  K+    +    +KP+
Sbjct  1847  LTCQI---LEQKIKELDS------CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT  1897

Query  526   LSLPRKTKDR  535
               L   T+++
Sbjct  1898  ELLEENTEEK  1907


>gi|51315800|sp|Q9UPA5|BSN_HUMAN  Bassoon protein (Zinc-finger protein 231)
Length=3926

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 49/200 (24%), Positives = 84/200 (42%), Gaps = 37/200 (18%)

Query  217   VPLTTFKQIKEIGKEPAPAVREASPSWRSVVRWPTPSMIIISRKKEFDVDTLSKSELRML  276
             +P TT   IKE    PAPA              P      +SR   F+ +  S+ E +  
Sbjct  2311  LPTTTPAAIKEAAGAPAPAPLAGQKPPADAA--PGGGSGALSRPG-FEKEEASQEERQRK  2367

Query  277   LSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQR  336
                   +LE   + +E LR+L              R +E   +ER          + LQR
Sbjct  2368  QQEQLLQLERERVELEKLRQL--------------RLQEELERER----------VELQR  2403

Query  337   DYEAGAGDKEKKPVCTNPLSILEAVMAHC-KKMQERMSAQLAAAESRQKKLEMEKLQLQA  395
               E      E++ +    L  L+ +  H  ++ QE   AQ A    ++++L  ++LQL+ 
Sbjct  2404  HRE------EEQLLVQRELQELQTIKHHVLQQQQEERQAQFAL---QREQLAQQRLQLEQ  2454

Query  396   LEQEHKKLAARLEEERGKNK  415
             ++Q  ++L  +LEE++ + K
Sbjct  2455  IQQLQQQLQQQLEEQKQRQK  2474


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 31/138 (22%), Positives = 65/138 (47%), Gaps = 28/138 (20%)

Query  377   AAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEA  436
             A+ E RQ+K + + LQL+    E +KL     +E  + ++V L   +E +QL   V  E 
Sbjct  2359  ASQEERQRKQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHREEEQL--LVQREL  2416

Query  437   QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQL---RAKLN  493
             Q+L+ +                       +   ++ Q E++ ++F  +REQL   R +L 
Sbjct  2417  QELQTI-----------------------KHHVLQQQQEERQAQFALQREQLAQQRLQLE  2453

Query  494   REEAHTTDLKEEIDKMRK  511
             + +     L++++++ ++
Sbjct  2454  QIQQLQQQLQQQLEEQKQ  2471


>gi|57012622|sp|Q9P2G1|AKIB1_HUMAN  Ankyrin repeat and IBR domain-containing protein 1
Length=1214

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 23/78 (29%), Positives = 36/78 (46%), Gaps = 11/78 (14%)

Query  1005  DCVRLLLS-----------AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHA  1053
             DC++++L              A ++A D    TPL  AAA G   CVELL+ +  ++   
Sbjct  240   DCLQMILKWKGAKLDQGEYERAAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAE  299

Query  1054  ADGGQTPLYLACKNGNKE  1071
              +   TP   A K  +K+
Sbjct  300   NENKDTPCDCAEKQHHKD  317


>gi|57015410|sp|Q8NDV3|SM1L2_HUMAN  Structural maintenance of chromosome 1-like 2 protein (SMC1beta 
protein)
Length=1235

 Score = 35.4 bits (80),  Expect = 0.24
 Identities = 49/219 (22%), Positives = 89/219 (40%), Gaps = 38/219 (17%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG-----  412
            LE V       +E +S      ++R+K+  M   QLQ  E+E K +   L ++R      
Sbjct  242  LEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKA  301

Query  413  --------KNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEK  464
                    K   V    +K+ ++   K  ++ + LE  +A L+   +   +  EE    K
Sbjct  302  KENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHK  361

Query  465  RRSTEMEA----------------------QMEKQLSEFDTEREQLRAKLNRE---EAHT  499
            +R  E+EA                      Q+EK   E  T+ E+L  +  R    + + 
Sbjct  362  KRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNL  421

Query  500  TDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLV  538
              +KE+I+  +K IE+L+  + +       +K ++  LV
Sbjct  422  KQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLV  460


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 44/198 (22%), Positives = 87/198 (43%), Gaps = 10/198 (5%)

Query  366  KKMQERMSAQLAAAESRQKKLEM-EKLQLQALEQEHKKLAARLEEERGKNKQVVLML--V  422
            K++Q  +       +  Q +LEM +K  L A  QE  +L + L        Q +++   +
Sbjct  699  KQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSEL---LNIESQCIMLSEGI  755

Query  423  KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM---EKQLS  479
            KE ++   +  E+  K+ED + +   E+     + E  +   +R  E++ +    +K L+
Sbjct  756  KERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRYFYKKMLT  815

Query  480  EFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVS  539
              + + E  R+ L ++      LKE I K  + I+ LK+  ++          K ++L  
Sbjct  816  RLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKD  875

Query  540  ISVGTEGTVTRSVACQTD  557
            I V T+ +    V  Q +
Sbjct  876  IRV-TQNSSAEKVQTQIE  892


>gi|13431716|sp|Q9UKX2|MYH2_HUMAN  Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain 
IIa) (MyHC-IIa)
Length=1941

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 58/256 (22%), Positives = 110/256 (42%), Gaps = 18/256 (7%)

Query  278   SVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPFLALQRD  337
             S+M+ E E + L  E L++ ++      +K E+ +   + +Q++     L      L+ +
Sbjct  1071  SIMDIENEKQQLD-EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKE--LQARIEELEEE  1127

Query  338   YEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQERMSAQLAA-----AESRQKKLEMEKL  391
              EA    + K     + LS  LE +    ++     SAQ+       AE ++ + ++E+ 
Sbjct  1128  IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA  1187

Query  392   QLQ------ALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAk  445
              LQ       L ++H    A L E+    ++V   L KE  ++  ++ + A  +E V   
Sbjct  1188  TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA  1247

Query  446   leeekkktneleeelSAEKRRSTEMEA---QMEKQLSEFDTEREQLRAKLNREEAHTTDL  502
                 +K    LE++LS  K +  E +     +  Q     TE  +   +L+ +EA  + L
Sbjct  1248  KGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQL  1307

Query  503   KEEIDKMRKMIEQLKR  518
                     + IE+LKR
Sbjct  1308  SRGKQAFTQQIEELKR  1323


 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 61/311 (19%), Positives = 123/311 (39%), Gaps = 62/311 (19%)

Query  355   LSILEAVMAHCKKMQERMSAQLAA-AESRQKKLEMEKLQLQALEQEHKKLAARLEE----  409
             L  LE +    K +Q+ +S      AE  ++  E+EK++ Q +EQE  +L A LEE    
Sbjct  1498  LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ-VEQEKCELQAALEEAEAS  1556

Query  410   ---ERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRR  466
                E GK  ++ L L +   ++  K+ E+ ++++ +        +      +     +  
Sbjct  1557  LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND  1616

Query  467   STEMEAQMEKQLSEFDTE-----------------------------------REQLRAK  491
             +  ++ +ME  L+E + +                                   +E L+ +
Sbjct  1617  AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ  1676

Query  492   LNREEAHTTDLKEEIDKMRKMIEQLKRGS--------DSKPSLSLPRKTKDRRLVSISVG  543
             L   E     L+ EI+++R  +EQ +R          D+   + L   T++  L++    
Sbjct  1677  LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL-LHTQNTSLINTKKK  1735

Query  544   TEGTVTRSVACQTDLVTE--NADHMKKLPLTMPVKPSTGSPLVSANAKGSVCTSATMARP  601
              E  +++      D++ E  NA+   K       K  T + +++   K    TSA + R 
Sbjct  1736  LETDISQMQGEMEDILQEARNAEEKAK-------KAITDAAMMAEELKKEQDTSAHLERM  1788

Query  602   GIDRQASYGDL  612
               + + +  DL
Sbjct  1789  KKNMEQTVKDL  1799


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 33/149 (22%), Positives = 71/149 (47%), Gaps = 24/149 (16%)

Query  384  KKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV---VLMLVKECKQLSGKVIEEAQKLE  440
            K  E EK ++  +++E +K+   L +   K K++   ++ L+KE   L  +V  EA+ L 
Sbjct  847  KSAETEK-EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA  905

Query  441  DVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTERE---QLRAKLNREEA  497
            D   + ++                +   ++EA++++     + E E   +L AK  + E 
Sbjct  906  DAEERCDQLI--------------KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED  951

Query  498  HTTDLKEEIDKMR---KMIEQLKRGSDSK  523
              ++LK++ID +      +E+ K  +++K
Sbjct  952  ECSELKKDIDDLELTLAKVEKEKHATENK  980


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 42/165 (25%), Positives = 74/165 (44%), Gaps = 10/165 (6%)

Query  376   LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL---MLVKECKQLSGKV  432
             LA AE R  +L   K+QL+A   + K++  R E+E   N ++      L  EC +L    
Sbjct  904   LADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEINAELTAKKRKLEDECSELK---  957

Query  433   IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKL  492
              ++   LE  +AK+E+EK  T    + L+ E     E  A++ K+        +Q    L
Sbjct  958   -KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL  1016

Query  493   NREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
               EE     L +   K+ + ++ L+   + +  L +  +   R+L
Sbjct  1017  QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL  1061


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 56/251 (22%), Positives = 110/251 (43%), Gaps = 24/251 (9%)

Query  303   IKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVM  362
             IKT     A+ KEV  +       +N    A +R  E    + +K       +  LE  +
Sbjct  915   IKTKIQLEAKIKEV-TERAEDEEEINAELTAKKRKLEDECSELKKD------IDDLELTL  967

Query  363   AHCKKMQ-------ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNK  415
             A  +K +       + ++ ++A  +    KL  EK   +AL++ H++    L+ E  K  
Sbjct  968   AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK---KALQEAHQQTLDDLQAEEDKVN  1024

Query  416   QVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ-M  474
              +    +K  +Q+    +E + + E  +    E  K+  E + +L+ E     E E Q +
Sbjct  1025  TLTKAKIKLEQQVDD--LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQL  1082

Query  475   EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD----SKPSLSLPR  530
             +++L + + E   L++K+  E+A    L+++I +++  IE+L+   +    S+      R
Sbjct  1083  DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR  1142

Query  531   KTKDRRLVSIS  541
                 R L  IS
Sbjct  1143  SDLSRELEEIS  1153


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 64/316 (20%), Positives = 124/316 (39%), Gaps = 42/316 (13%)

Query  255   IIISRKKEFDVDTLSKSELRMLLSVMEGELE--------ARDLVIEALRELKWFTGI---  303
             I+ S +   D +  S+++   L   MEG+L         A  +  EALR  +   GI   
Sbjct  1599  IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKD  1658

Query  304   KTAKWENARRKEVFIQERYG----RFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILE  359
                  ++A R +  ++E+      R NL      LQ + E      E+         I E
Sbjct  1659  TQIHLDDALRSQEDLKEQLAMVERRANL------LQAEIEELRATLEQTE---RSRKIAE  1709

Query  360   AVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL  419
               +    +  + +  Q  +  + +KKLE +  Q+Q   ++  + A   EE+  K      
Sbjct  1710  QELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAA  1769

Query  420   MLVKECK--QLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKR------RSTEME  471
             M+ +E K  Q +   +E  +K  +   K  + +    E       +K+      R  E+E
Sbjct  1770  MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE  1829

Query  472   AQME----------KQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD  521
              ++E          K L + +   ++L  +   +  +   L++ +DK++  ++  KR ++
Sbjct  1830  GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE  1889

Query  522   SKPSLSLPRKTKDRRL  537
                  S     K R+L
Sbjct  1890  EAEEQSNTNLAKFRKL  1905


>gi|12643642|sp|O75912|DGKI_HUMAN  Diacylglycerol kinase iota (Diglyceride kinase iota) (DGK-iota) 
(DAG kinase iota)
Length=1065

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 45/191 (23%), Positives = 76/191 (39%), Gaps = 32/191 (16%)

Query  925   PGASDSLLVTASG----WSPSLTPLLMSGG-----------------------PAPLAGR  957
             PG  D ++  ASG    W+P+L   ++S                          +P++  
Sbjct  867   PGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSE  926

Query  958   PTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS---AE  1014
                + QA   G++  L       G  +     D  S L+ AAK G+ + V+ +L    +E
Sbjct  927   DHAILQAVIAGDLMKLIESYKNGG-SLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSE  985

Query  1015  AQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIK  1074
                 A  + G T L  AA Q +    +LL+   A++      G+TP   A + G+ + + 
Sbjct  986   LLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPD-LA  1044

Query  1075  LLLEAGTNRSV  1085
               LE+  N  V
Sbjct  1045  AYLESRQNYKV  1055


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)

Query  1031  AAAQGHFECVELLISYD-ANINHAADG--GQTPLYLACKNGNKECIKLLLEAGTNRSVKT  1087
             AA  G+ E V+ ++ +  + +   AD   G+T L+ A    N+   +LL++AG +     
Sbjct  966   AAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTD  1025

Query  1088  TDGWTPVHAAVDTGNVD  1104
             + G TP   A   G+ D
Sbjct  1026  SKGKTPQERAQQAGDPD  1042


>gi|67460585|sp|Q9BUQ8|DDX23_HUMAN  Probable ATP-dependent RNA helicase DDX23 (DEAD box protein 23) 
(100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog)
Length=820

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 23/109 (21%)

Query  335  QRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQ  394
            ++D E   GDK+ K     PLS LE ++A  K  +E        AE++ K L   + + +
Sbjct  125  KKDEEDEHGDKKLK---AQPLS-LEELLAKKKAEEE--------AEAKPKFLSKAEREAE  172

Query  395  ALEQEHKKLAAR---LEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLE  440
            AL++  +++  R   LEEER K KQ         + L  K++E+ Q+ E
Sbjct  173  ALKRRQQEVEERQRMLEEERKKRKQF--------QDLGRKMLEDPQERE  213


>gi|74759012|sp|Q7L7X3|TAOK1_HUMAN  Serine/threonine-protein kinase TAO1 (Thousand and one amino 
acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken 
homolog B) (hKFC-B)
Length=1001

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 39/164 (23%), Positives = 75/164 (45%), Gaps = 30/164 (18%)

Query  356  SILEAVMAHCKKMQERMSAQLAAAESRQK-KLEMEKLQLQA-LEQEHKKLAARLEEERGK  413
            S L   M+  K+M+ +   QL   E++ K +++  +L+L   LE +    AA +E+   K
Sbjct  458  SELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKK  517

Query  414  NKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ  473
            ++     + KE K +S    EE +  + + A                    ++  E+ + 
Sbjct  518  HQAA---MEKEAKVMSN---EEKKFQQHIQA--------------------QQKKELNSF  551

Query  474  MEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
            +E Q  E+   +EQL+ +LN  E  +T  KE+ + + K  E ++
Sbjct  552  LESQKREYKLRKEQLKEELN--ENQSTPKKEKQEWLSKQKENIQ  593


>gi|399227|sp|Q02224|CENPE_HUMAN  Centromeric protein E (CENP-E protein)
Length=2663

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 37/171 (21%), Positives = 85/171 (49%), Gaps = 17/171 (9%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC  425
             KK QE ++ +   A  ++ +L     +L  +E++ K+ + +L+E++    Q +L + +E 
Sbjct  1095  KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ----QQLLNVQEEM  1150

Query  426   KQLSGKV-----IEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSE  480
              ++  K+     ++   K +++  +  E ++     +   + E+ +S   E ++ K+L +
Sbjct  1151  SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQK  1210

Query  481   -FDTEREQLRAKLNREEAHTTDLKEE-------IDKMRKMIEQLKRGSDSK  523
              F+TER+ LR  +   EA     KEE       + + ++ I++L+R    K
Sbjct  1211  SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK  1261


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 37/165 (22%), Positives = 70/165 (42%), Gaps = 12/165 (7%)

Query  364   HCKKMQERMSAQLAAAESRQKKLE-MEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLV  422
             H K+ QE +         +  KL  M+K     LE  + KL  +++E +    Q++  L 
Sbjct  1782  HLKEQQETIDKLRGIVSEKTDKLSNMQK----DLENSNAKLQEKIQELKANEHQLIT-LK  1836

Query  423   KECKQLSGKVIEEAQ-----KLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
             K+  +   KV E  Q     K + +     E +      E   + E+ +S   E    ++
Sbjct  1837  KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQELHENLEEMKSVMKERDNLRR  1896

Query  478   LSE-FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSD  521
             + E    ER+QL+  L   +A   ++++E+   R + ++ K   D
Sbjct  1897  VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD  1941


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 22/114 (19%), Positives = 52/114 (45%), Gaps = 8/114 (7%)

Query  463  EKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDS  522
            E  R  +    + K+  +FD+    L+ +L+ +     +   E+ +    +EQLK   ++
Sbjct  839  ENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN  898

Query  523  KPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVK  576
            + S   P +T +R    I+   + T+      +   +T+  D +K+L  ++ ++
Sbjct  899  RDS---PLQTVEREKTLITEKLQQTLE-----EVKTLTQEKDDLKQLQESLQIE  944


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 41/183 (22%), Positives = 71/183 (38%), Gaps = 17/183 (9%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
             L+    H K+ QE +     +   +  ++    +  Q LE+ H KL   +       +Q 
Sbjct  1237  LKIAHIHLKEHQETIDELRRSVSEKTAQI----INTQDLEKSHTKLQEEIPVLH--EEQE  1290

Query  418   VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
             +L  VK       KV E  + + ++    E+   K +     +  E+ R  E   + +++
Sbjct  1291  LLPNVK-------KVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEE  1343

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
             +     ER+ L+      E     LKE I +    I++    S SK   SL  K KD   
Sbjct  1344  IKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE----SQSKQEQSLNMKEKDNET  1399

Query  538   VSI  540
               I
Sbjct  1400  TKI  1402


>gi|2833265|sp|Q15695|U2AFL_HUMAN  U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit 
related-protein 1 (U2(RNU2) small nuclear RNA auxillary 
factor 1-like 1)
Length=479

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 39/166 (23%), Positives = 76/166 (45%), Gaps = 11/166 (6%)

Query  384  KKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKEC----KQLSGKVIEEAQKL  439
            +K+   K      +  HKK  A L++E+ K ++  L  +++     ++     IEE Q  
Sbjct  5    EKMTFPKKMTFPEKPSHKKYRAALKKEKRKKRRQELARLRDSGLSQEEEEDTFIEEQQLE  64

Query  440  EDVMAkleeekkktneleeelSAEK--RRSTEMEAQMEKQLSEFDTE-----REQLRAKL  492
            E+ + + E E+     L  E  A++  R   E E   +K L E + +     +EQ R + 
Sbjct  65   EEKLLERERERLHEEWLLREQKAQEEFRIKKEKEEAAKKWLEEQERKLKEQWKEQQRKER  124

Query  493  NREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLV  538
              EE    + KE+ + ++KM++Q +   ++  +   P    D R++
Sbjct  125  EEEEQKQQEKKEKEEAVQKMLDQAENDLENSTTWQNPEPPVDFRVM  170


>gi|84027768|sp|O75150|BRE1B_HUMAN  Ubiquitin-protein ligase BRE1B (BRE1-B) (RING finger protein 
40) (95 kDa retinoblastoma-associated protein) (RBP95)
Length=1001

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 19/278 (6%)

Query  266  DTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRF  325
            D ++ +E ++L   ME  +E     IE LR+ +       A+         ++      F
Sbjct  263  DKVTSAETKVL--EMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSSGF  320

Query  326  NLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCK---KMQERMSAQLAAAESR  382
                  L++Q+     A  +E + +  + ++ LE + A  +   +  ER+   L +    
Sbjct  321  QGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEE  380

Query  383  QKKLEMEKLQLQA----LEQEHKKLAARLEEERG-----KNKQVVLMLVKECKQLS--GK  431
              +   E   LQA    L  E  ++  +L+E RG     KN  +  +   E  +L    K
Sbjct  381  VVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLATKNSHLRHIEHMESDELGLQKK  440

Query  432  VIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAK  491
            +  E  +LED +A++ +E +      E+  A   ++  +  +M   +S       QL+  
Sbjct  441  LRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGD  500

Query  492  LNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLP  529
              R +    +++ EI K+R    Q    + S P+L  P
Sbjct  501  AQRYKRKLREVQAEIGKLR---AQASGSAHSTPNLGHP  535


>gi|74728485|sp|Q8N137|LIP8_HUMAN  Centrobin (LYST-interacting protein 8)
Length=903

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 23/131 (17%)

Query  367  KMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECK  426
            ++++ +S  + A    Q+   +++ + + LE+E + L  RLE E    +Q   +L +E  
Sbjct  280  RLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAE----QQRCCVLQEERD  335

Query  427  QLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSE-FDTER  485
                  + E ++LE + A                + E+ R T   AQ E QL E +   +
Sbjct  336  AARAGQLSEHRELETLRA----------------ALEEERQT--WAQQEHQLKEHYQALQ  377

Query  486  EQLRAKLNREE  496
            E+ +A+L RE+
Sbjct  378  EESQAQLEREK  388


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 57/272 (20%), Positives = 109/272 (40%), Gaps = 28/272 (10%)

Query  255  IIISRKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRK  314
            +   RKK+  ++ L K+  R++      E E  +++     E +     ++ + E   R 
Sbjct  222  VAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRL  281

Query  315  EVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSA  374
            E  + E     N       LQ+  E    ++E++ +       LEA    C  +QE   A
Sbjct  282  EQSLSEAMEALNREQESARLQQR-ERETLEEERQALTLR----LEAEQQRCCVLQEERDA  336

Query  375  QLAAAESRQKKLEMEKLQLQA-----LEQEH----------KKLAARLEEERGKNKQVVL  419
              A   S  ++LE  +  L+       +QEH          ++  A+LE E+ K+++   
Sbjct  337  ARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQ  396

Query  420  MLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAE-KRRSTEMEAQMEKQL  478
               +   QL+  V  E ++LE  +     E+         + A  + +  ++E+++  QL
Sbjct  397  AAWETQHQLA-LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL  455

Query  479  SEFDTER------EQLRAKLNREEAHTTDLKE  504
             +  TER        LR   +  E H   L++
Sbjct  456  EQRVTERLAQAQESSLRQAASLREHHRKQLQD  487


>gi|71152997|sp|Q7Z3E2|CJ118_HUMAN  Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2)
Length=898

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 34/147 (23%), Positives = 72/147 (48%), Gaps = 10/147 (6%)

Query  381  SRQKKLEMEKLQLQALEQEHKKLAARLE------EERGKNKQVVLMLVKECKQLSGKVIE  434
            SR + +  +     A++Q HK++A R+E      EE  + K+ ++M     ++ S  + +
Sbjct  268  SRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK  327

Query  435  EAQKLEDVMAkleeekkktneleeelSAEKRRSTEM----EAQMEKQLSEFDTEREQLRA  490
            E + LE  +    +E +K     ++LS EK R  ++    E +  + + E D  +E + +
Sbjct  328  EKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINS  387

Query  491  KLNREEAHTTDLKEEIDKMRKMIEQLK  517
             + + +     LK E+D  ++  ++LK
Sbjct  388  HVIKVKWAQNKLKAEMDSHKETKDKLK  414


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 46/216 (21%), Positives = 97/216 (44%), Gaps = 18/216 (8%)

Query  366  KKMQERMSAQLAAAESRQKKLEME-KLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKE  424
            K  Q+ +     + E +  +L+ + ++    LE++ ++ + +LE    K        +KE
Sbjct  432  KNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK--------IKE  483

Query  425  CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
             + L     E   +L  +  K++  + +    E+ELS  K      +A+++  L +  T 
Sbjct  484  LEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTA  543

Query  485  REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK------RGSDSKPSLSLPRKT-KDRRL  537
             +QL+ +L R +    +LKEE++ +  +I  L+      R  +S+  L   R T K+ +L
Sbjct  544  -DQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQL  602

Query  538  VSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTM  573
             S S   +    + V+C    +    + MK+  + +
Sbjct  603  QSESNSLQSQFDK-VSCSESQLQSQCEQMKQTNINL  637


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 54/242 (22%), Positives = 102/242 (42%), Gaps = 41/242 (16%)

Query  303  IKTAKWENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVM  362
            IK    EN + +E+F+     + NL +    L++  E    +K+         S +E + 
Sbjct  209  IKKLIKENKKHQELFVDICSEKDNLREE---LKKRTET---EKQHMNTIKQLESRIEELN  262

Query  363  AHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLV  422
               K  ++++ AQ   A++  ++L  E    Q +EQ +KK     EE R + + +V+  V
Sbjct  263  KEVKASRDQLIAQDVTAKNAVQQLHKE--MAQRMEQANKKC----EEARQEKEAMVMKYV  316

Query  423  KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM----EAQMEKQL  478
            +  K+ S  + +E + LE  +    +E +K     ++LS EK R  ++    E +  + +
Sbjct  317  RGEKE-SLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLI  375

Query  479  SEFDTEREQLRA------------------------KLNREEAHTTDLKEEIDKMRKMIE  514
             E D  +E + +                        KL       T  KEE D++RK  +
Sbjct  376  REIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQ  435

Query  515  QL  516
             +
Sbjct  436  DM  437


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 37/169 (21%), Positives = 65/169 (38%), Gaps = 3/169 (1%)

Query  384  KKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVM  443
            KKL  E  + Q L  +       L EE  K  +     +   KQL  + IEE  K  +V 
Sbjct  210  KKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESR-IEELNK--EVK  266

Query  444  AkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLK  503
            A  ++   +    +  +    +   +   Q  K+  E   E+E +  K  R E  + DL+
Sbjct  267  ASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLR  326

Query  504  EEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSV  552
            +E + + K +    +  +   +       +  RL  +    EG  TR +
Sbjct  327  KEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLI  375


>gi|27923959|sp|Q03001|BPA1_HUMAN  Bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kDa bullous 
pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) 
(Dystonia musculorum protein) (Dystonin)
Length=3214

 Score = 35.0 bits (79),  Expect = 0.32
 Identities = 38/180 (21%), Positives = 84/180 (46%), Gaps = 17/180 (9%)

Query  361   VMAHCKKMQERMSAQLAAAESRQK----KLEMEKLQLQALEQEHKKLAARLE----EERG  412
             ++ + KK    ++A+L A++  ++    K+++++ Q+Q L    KK+   L     EE+ 
Sbjct  2238  IIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQM  2297

Query  413   KNKQVVLMLVK--ECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEM  470
              ++++VL   +  + KQ + +  ++ +KL +     E +          L  E  R+ E 
Sbjct  2298  THRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQEN  2357

Query  471   EAQMEKQLSEFDTE----REQLRAKLNREEAH---TTDLKEEIDKMRKMIEQLKRGSDSK  523
                 E  + E + +    REQ++   + E  H      L++E+   ++ +E LK+  D +
Sbjct  2358  AKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQ  2417


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 44/195 (22%), Positives = 88/195 (45%), Gaps = 23/195 (11%)

Query  359   EAVMAHCKKMQERMSAQLAAAESRQKKLEM--EKLQLQA-LEQEHKKLAARLEEERGKNK  415
             E ++   + +Q+R  A    A+  + +L    E L  Q   EQ+ ++    LEE+  K++
Sbjct  2163  ENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQ  2222

Query  416   QVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQME  475
              +V    ++C Q +  +    +++ ++ A            E   S E++R  E + Q++
Sbjct  2223  NLVSEFKQKCDQQNIIIQNTKKEVRNLNA------------ELNASKEEKRRGEQKVQLQ  2270

Query  476   K-QLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
             + Q+ E +      R K  ++E H   ++E++   RKM+   +     K S    RK K 
Sbjct  2271  QAQVQELNN-----RLKKVQDELHLKTIEEQMTH-RKMVLFQEESGKFKQSAEEFRK-KM  2323

Query  535   RRLVSISVGTEGTVT  549
              +L+   V TE  ++
Sbjct  2324  EKLMESKVITENDIS  2338


>gi|42558941|sp|O75145|LIPA3_HUMAN  Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f 
polypeptide-interacting protein alpha-3) (PTPRF-interacting 
protein alpha-3)
Length=1194

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 37/152 (24%), Positives = 72/152 (47%), Gaps = 5/152 (3%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
            L+  +A  + M+ER++       S Q++          LE E     +   +   K++Q+
Sbjct  291  LKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQL  350

Query  418  VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
               L  + KQ   + +++A+ L ++ A+L +     N+ EE     + R  ++EAQ+E++
Sbjct  351  AEWL-DDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEK  409

Query  478  LSEFDTEREQLRAKLNREEAHTTDLKEEIDKM  509
              E    R+  R K+N +  H   L E +DK+
Sbjct  410  NQELQRARQ--REKMNDD--HNKRLSETVDKL  437


>gi|32469749|sp|Q8TBA6|GOGA5_HUMAN  Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) 
(Ret-II protein)
Length=731

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 32/148 (21%), Positives = 59/148 (39%), Gaps = 23/148 (15%)

Query  381  SRQKKLEMEKL--QLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQK  438
            S    +E+E+L  + +   +E +KL  ++ + R + + +    V E +       E+ Q 
Sbjct  461  STASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAR----EQLQD  516

Query  439  LEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAH  498
            L D +A                  +K    E+E ++E+   EF    E L    N  ++ 
Sbjct  517  LHDQIA-----------------GQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSR  559

Query  499  TTDLKEEIDKMRKMIEQLKRGSDSKPSL  526
              D  EEI K+R  +      + S+  L
Sbjct  560  IKDRDEEIQKLRNQLTNKTLSNSSQSEL  587


>gi|62286590|sp|O94986|CE152_HUMAN  Centrosomal protein of 152 kDa (Cep152 protein)
Length=1275

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 11/101 (10%)

Query  339   EAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQ  398
             +A   + +KK V    L I +    HC +  E+   +    +  + KLE     LQ LE+
Sbjct  1056  QATEAEADKKKV----LEIKDLCCGHCFQELEKAKQE---CQDLKGKLEKCCRHLQHLER  1108

Query  399   EHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKL  439
             +HK +  ++ EE   N +VV  L++E   +  K +EE Q L
Sbjct  1109  KHKAVVEKIGEE---NNKVVEELIEENNDMKNK-LEELQTL  1145


>gi|131011|sp|P10162|PRB4L_HUMAN  Basic salivary proline-rich protein 4 allele L (Salivary proline-rich 
protein Po) (Parotid o protein) [Contains: Peptide 
P-D]
Length=276

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 22/67 (32%), Positives = 24/67 (35%), Gaps = 0/67 (0%)

Query  706  PDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGAPSRPGVPPTGDV  765
            P Q GN +Q PP     P SR      Q      T        PQ G  S+   PP G  
Sbjct  69   PPQGGNQSQGPPPHPGKPESRPPQGGHQSQGPPPTPGKPEGPPPQGGNQSQGTPPPPGKP  128

Query  766  GTHPPVG  772
               PP G
Sbjct  129  EGRPPQG  135


>gi|731165|sp|Q02040|XE7_HUMAN  B-lymphocyte antigen precursor (B-lymphocyte surface antigen) 
(721P) (Protein XE7)
Length=695

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 42/179 (23%), Positives = 84/179 (46%), Gaps = 11/179 (6%)

Query  366  KKMQERMSAQ-LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKE  424
            K+  ER   Q L      QK+ E E  + Q  E+  +K    LE ER + ++   +  +E
Sbjct  270  KRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEK---LRKRE  326

Query  425  CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTE  484
             KQ   ++    +KLE + A    E++K  + + +L   K    +   Q  + ++E  + 
Sbjct  327  QKQRDRELRRNQKKLEKLQA----EEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSR  382

Query  485  REQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKP-SLSLPRKTKD--RRLVSI  540
             + ++ +   ++     L+++ ++ R    +L+R  + K  +L L RK ++   RL+SI
Sbjct  383  AKAVKLREQEQKEEKLRLQQQEERRRLQEAELRRVEEEKERALGLQRKERELRERLLSI  441


 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 33/148 (22%), Positives = 62/148 (41%), Gaps = 23/148 (15%)

Query  376  LAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEE  435
            L+ A  ++++LE +KLQ    ++E +K   +  EER +         +E KQ   + +E 
Sbjct  263  LSDASIKKRQLERQKLQELEQQREEQKRREKEAEERQR--------AEERKQKELEELER  314

Query  436  AQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNRE  495
             +K E+ +                   +K+R  E+    +K       E++QL+ K+  E
Sbjct  315  ERKREEKL---------------RKREQKQRDRELRRNQKKLEKLQAEEQKQLQEKIKLE  359

Query  496  EAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
            E      +  +  +R + E L R    K
Sbjct  360  ERKLLLAQRNLQSIRLIAELLSRAKAVK  387


>gi|74753569|sp|Q4V328|GRAP1_HUMAN  GRIP1-associated protein 1 (GRASP-1)
Length=841

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 40/174 (22%), Positives = 79/174 (45%), Gaps = 15/174 (8%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQL  428
            ++ M  +LA    ++K    E+L    L  E + L  R   ER + +++     ++ ++L
Sbjct  429  RKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYER-ELRELHEDKKRQEEEL  487

Query  429  SGKVIEEAQKLEDVMAkleeekkktneleeelSAE---KRRSTEMEAQMEKQLSEFDTER  485
             G++ EE  +  ++    +  ++   ++     A+   +RR  E E  +++Q  E +   
Sbjct  488  RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEAL  547

Query  486  EQLRAKLNREEAHTTDLK---EEIDKMRKMIEQLKRGSDS--KPSLSLPRKTKD  534
            +Q R      E H  +LK   EE+  +R  +EQ +   D   K   SL ++ KD
Sbjct  548  KQCR------EQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKD  595


>gi|50400772|sp|Q8N4C6|NIN_HUMAN  Ninein (hNinein)
Length=2090

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 37/155 (23%), Positives = 75/155 (48%), Gaps = 15/155 (9%)

Query  366  KKMQERMSAQLAAAESRQKKLEMEKLQL---QALEQEHKKLAARLEEERGKNKQVVLMLV  422
            +K+ E    ++AA ++  +K   + LQ    Q LE E +   A+ EE   +++  + + +
Sbjct  420  RKLDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDR--LALSL  477

Query  423  KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFD  482
            KE  +L  +++E A+KL    A+ E    K     E + AEK         ++   +EF 
Sbjct  478  KENSRLENELLENAEKL----AEYENLTNKLQRNLENVLAEKF------GDLDPSSAEFF  527

Query  483  TEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLK  517
             + E+L    N  E     L++++D+++  +E+ +
Sbjct  528  LQEERLTQMRNEYERQCRVLQDQVDELQSELEEYR  562


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 31/150 (20%), Positives = 77/150 (51%), Gaps = 26/150 (17%)

Query  363   AHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLV  422
             A  +KM E +  Q++  + + ++L++E  +L    Q++ +   +L+E    N+++  ML 
Sbjct  1566  AAVQKMVENLKKQISELKIKNQQLDLENTELS---QKNSQNQEKLQE---LNQRLTEMLC  1619

Query  423   KECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFD  482
             ++ K+     +EE ++ +  + +  E               K +S+ + + +E +LSE  
Sbjct  1620  QKEKEPGNSALEEREQEKFNLKEELERC-------------KVQSSTLVSSLEAELSEV-  1665

Query  483   TEREQLRAKLNREEAHTTDLKEEIDKMRKM  512
                 +++  + ++E H   LK+E++KM+++
Sbjct  1666  ----KIQTHIVQQENHL--LKDELEKMKQL  1689


>gi|74713839|sp|Q86SQ7|SDCG8_HUMAN  Serologically defined colon cancer antigen 8 (Centrosomal colon 
cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8)
Length=713

 Score = 34.7 bits (78),  Expect = 0.41
 Identities = 47/176 (26%), Positives = 85/176 (48%), Gaps = 35/176 (19%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGK--NKQVVLM------  420
            QE+ S Q    +S  K+ + + LQ Q  EQE  +   ++E +  K  N+Q +L+      
Sbjct  540  QEKDSIQ----QSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTF  595

Query  421  ---LVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ----  473
               L +EC  L+ K+ + +QK    +A+L +EK+ T +   +L   +RR+ E+E Q    
Sbjct  596  LTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKL---QRRNEELEEQCVQH  652

Query  474  ------MEKQLSEFDTERE-------QLRAKLNREEAHTTDLKEEIDKMRKMIEQL  516
                  M+++L + D   +       QL +K N+       L EE+D++R  +  +
Sbjct  653  GRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSM  708


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 30/156 (19%), Positives = 73/156 (46%), Gaps = 5/156 (3%)

Query  372  MSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERG---KNKQVVLMLVKECKQL  428
            M    A  E R+ + +  +  L+  +QE +KL   L+E +    + +Q   +  +EC +L
Sbjct  466  MEKDEAEKEHREFRAKTNR-DLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRL  524

Query  429  SGKVIEEAQKLEDVMAkleeekkktneleeelSAE-KRRSTEMEAQMEKQLSEFDTEREQ  487
            +  + E   +L     + +  ++  ++  +  + + ++R  E+  ++++  ++ D    +
Sbjct  525  TELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENE  584

Query  488  LRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
                L  +    T LKEE   + K +EQ+ + + S+
Sbjct  585  QYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSE  620


>gi|6176569|sp|Q99490|CENG1_HUMAN  Centaurin-gamma 1
Length=836

 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 35/107 (32%), Positives = 47/107 (43%), Gaps = 6/107 (5%)

Query  942   LTPLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGH--SALYSAA  999
             L PL  S  P    GR  L     AQ   T+L +L +     ++ S ED    S L+ AA
Sbjct  688   LAPLSTSEEPL---GRQ-LWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAA  743

Query  1000  KNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISY  1046
             +  H    +LLL   A V A D  G T L  A   G   C ++L+ +
Sbjct  744   ELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH  790


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 5/77 (6%)

Query  1009  LLLSAEAQ-----VNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYL  1063
             LLL A A+      +  D    +PL  AA   H    +LL+ Y A++      G+T L+ 
Sbjct  715   LLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFY  774

Query  1064  ACKNGNKECIKLLLEAG  1080
             A + G++ C  +LL+ G
Sbjct  775   ARQAGSQLCADILLQHG  791


>gi|13124654|sp|Q9UPV9|OI106_HUMAN  106 kDa O-GlcNAc transferase-interacting protein (Trafficking 
protein, kinesin-binding 1)
Length=953

 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 65/300 (21%), Positives = 121/300 (40%), Gaps = 45/300 (15%)

Query  338  YEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQ-LAAAESRQKKLEMEKLQLQAL  396
            Y + A + E + VC+ PL          K+ +   S Q     +S QKKL+  + +   L
Sbjct  178  YTSAAEESEPESVCSTPL----------KRNESSSSVQNYFHLDSLQKKLKDLEEENVVL  227

Query  397  EQEHKKLAARLEEERGKNKQVVLMLVKECK----QLSGKVIEEAQKLEDVMAkleeekkk  452
              E  +L         K +Q+V   VKE +    Q++    E A+K ED   + EE    
Sbjct  228  RSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHL  287

Query  453  tneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKM  512
             +++ +     K  + E E  ++   +  D +R+            T +L+E  DK  + 
Sbjct  288  LSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQL-----------TAELRELEDKYAEC  336

Query  513  IEQLKRGSDSKPSL---SLPRKTKDR-------RLVSISVGTEGTVTRSVACQTDLVTEN  562
            +E L    +   +L   ++P  T  R        + S++   EGT+ + +  + +  + +
Sbjct  337  MEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLE-EAESPD  395

Query  563  ADHMKKLPLT-------MPVKPSTGSPL-VSANAKGSVCTSATMARPGIDRQASYGDLIG  614
              H K++  T       +  +  T SP+ +  + + S   S   +     R + YG  IG
Sbjct  396  ITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIG  455


>gi|44887818|sp|Q96NX9|DACH2_HUMAN  Dachshund homolog 2 (Dach2)
Length=599

 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 7/97 (7%)

Query  463  EKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEID---KMRKMIEQ-LKR  518
            E  R  E+   +E+QL+     R  ++ +L +E+     L+E ++   K R+ +EQ LK+
Sbjct  490  ELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRREQVEQALKQ  549

Query  519  GSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSVACQ  555
             + S   L   R  KD  +  I +   GT   S A Q
Sbjct  550  ATTSDSGL---RMLKDTGIPDIEIENNGTPHDSAAMQ  583


>gi|13124704|sp|Q14457|BCN1_HUMAN  Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein 
GT197)
Length=450

 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 36/126 (28%), Positives = 60/126 (47%), Gaps = 4/126 (3%)

Query  386  LEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAk  445
            L+    QL   E E +     LE     N+     L  E K+L+ +     Q+LEDV   
Sbjct  145  LDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDV---  201

Query  446  leeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEE  505
             E+ +K   E  E++ AE  R  + EAQ +++ SEF  ++ +L  +L   E      + +
Sbjct  202  -EKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQ  260

Query  506  IDKMRK  511
            +DK++K
Sbjct  261  LDKLKK  266


>gi|32469788|sp|Q9NYA3|GOGA6_HUMAN  Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like 
protein)
Length=693

 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 31/152 (20%), Positives = 73/152 (48%), Gaps = 3/152 (1%)

Query  367  KMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECK  426
            + QERM      A + +++ + +  ++Q LE+   +L  ++ E        V  +V++ +
Sbjct  242  RWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQ  301

Query  427  QLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTERE  486
              +  + +E + LE  +    E  +  + L      +K+R  E E  + +Q ++   E+E
Sbjct  302  DEAKHLRQEVEGLEGKLQSQVENNQALSLLS---KEQKQRLQEQEEMLREQEAQRVREQE  358

Query  487  QLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
            +L  +  R       L+E+ +++RK  ++L++
Sbjct  359  RLCEQNERLREQQKTLQEQGERLRKQEQRLRK  390


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 41/161 (25%), Positives = 71/161 (44%), Gaps = 4/161 (2%)

Query  345  KEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLA  404
            KE+K        +L    A   + QER+  Q      +QK L+ +  +L+  EQ  +K  
Sbjct  333  KEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQE  392

Query  405  ARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEK  464
             RL +E  + ++    L  + ++L  K  E  QK E+ +A  +  K      E + S E 
Sbjct  393  ERLRKEEERLQKQEKRLWDQEERL-WKKEERLQKQEERLALSQNHKLDKQLAEPQCSFED  451

Query  465  RRSTEMEA-QMEKQLSEFD--TEREQLRAKLNREEAHTTDL  502
              + +  A Q+E+Q+ E     + E L A  ++ +   T L
Sbjct  452  LNNEKKSALQLEQQVKELQEKLDEEHLEAASHQNQQLETQL  492


>gi|41688592|sp|Q96ED9|HOOK2_HUMAN  Hook homolog 2 (h-hook2) (hHK2)
Length=719

 Score = 34.3 bits (77),  Expect = 0.54
 Identities = 36/157 (22%), Positives = 69/157 (43%), Gaps = 34/157 (21%)

Query  384  KKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV--VLMLVKECKQLSGKVIEEAQKLED  441
            KKL + + QL+ L++E+ +L +  E+ER +  ++   +  ++   Q    + +EAQ L+D
Sbjct  236  KKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD  295

Query  442  VMAkleeekkktneleeelSAEKRRSTEMEAQME-------KQLSEFDTEREQLRAKLNR  494
             M                   E R+S+E   Q+E       ++L E    R Q+R    R
Sbjct  296  EM------------------DELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER  337

Query  495  EEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRK  531
               H        ++ R++ ++L+R    +  L   R+
Sbjct  338  NAGHA-------ERTRQLEDELRRAGSLRAQLEAQRR  367


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 34/161 (21%), Positives = 66/161 (40%), Gaps = 33/161 (20%)

Query  366  KKMQERMSAQLAAAESRQKKLE----MEKLQLQALEQEHKKLAARLEEERGKNKQVVLML  421
            ++ QE +   L  A   +  LE    + + QL  L  + + L   L+E+ GK +  + +L
Sbjct  479  RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISIL  538

Query  422  VKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEF  481
            +K       K+ E  QKL +                     E +R  E   ++E      
Sbjct  539  LKR------KLEEHLQKLHEA------------------DLELQRKREYIEELEPPTDSS  574

Query  482  DTER-EQLRAKLNREEAHTTDLKEE----IDKMRKMIEQLK  517
               R E+L+  L +++A    ++E     +DK R +++ ++
Sbjct  575  TARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTME  615


>gi|60392986|sp|Q92878|RAD50_HUMAN  DNA repair protein RAD50 (hRAD50)
Length=1312

 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 40/213 (18%), Positives = 90/213 (42%), Gaps = 25/213 (11%)

Query  344  DKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHK--  401
            ++E   VC   ++I+E      K ++ +++ Q A  +       ++++  +  E++HK  
Sbjct  781  EEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLD  840

Query  402  ----------KLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekk  451
                      KL    +E+    K     L  E  Q+S   ++  Q+LE+   +L  E +
Sbjct  841  TVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQRRQQLEEQTVELSTEVQ  899

Query  452  ktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNRE----EAHTTDLKEEID  507
                       E + + E  + +E  L +F  E+E+L  K N      +    D+KE++ 
Sbjct  900  SLY-------REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK  952

Query  508  KMRKMIEQLKRG-SDSKPSLSLPRKTKDRRLVS  539
             +   ++ ++    D K      ++T+  ++++
Sbjct  953  NIHGYMKDIENYIQDGKDDYKKQKETELNKVIA  985


>gi|3913958|sp|O15066|KIF3B_HUMAN  Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin 
motor 3B) (HH0048)
Length=747

 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 53/216 (24%), Positives = 98/216 (45%), Gaps = 39/216 (18%)

Query  382  RQKKLEMEKLQLQALEQEHKKLAA---RLEEERGKNKQVVLMLVKECKQLSGKVIEEAQK  438
            +Q+KLE+EK   +A+ ++H  +A    RL +E+ K  + +       + L  K+     K
Sbjct  417  QQEKLEIEK---RAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESK  473

Query  439  L----EDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ--------------LSE  480
            L    ++++    E++K   +  +E++ +KRR  E++ QME +                E
Sbjct  474  LLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQE  533

Query  481  FDTEREQLR---AKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
             D + ++L+   +KL   +A   DL+EE  K R+ +EQ +          L R+ K + L
Sbjct  534  VDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQN--------ELTRELKLKHL  585

Query  538  VSIS-VGTEGTVTRSVACQTDLVTENADHMKKLPLT  572
            +  + +  E    +S         E  DH K  P+T
Sbjct  586  IIENFIPLE---EKSKIMNRAFFDEEEDHWKLHPIT  618


>gi|13633994|sp|Q9UBN4|TRPC4_HUMAN  Short transient receptor potential channel 4 (TrpC4) (trp-related 
protein 4) (hTrp-4) (hTrp4)
Length=977

 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 42/162 (25%), Positives = 62/162 (38%), Gaps = 36/162 (22%)

Query  944   PLLMSGGPAPLAGRPTLLQQAAAQGNVTLLSMLLNEEGL--DINYSCED--GHSALYSAA  999
             PL +    + L+        A  +G+   +   L E  +   IN +C D  G +AL  A 
Sbjct  19    PLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAI  78

Query  1000  KNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQ-  1058
             +N + + + LLLS    V  A       L  A  +     VELL+      NH    G+ 
Sbjct  79    ENENLELIELLLSFNVYVGDA-------LLHAIRKEVVGAVELLL------NHKKPSGEK  125

Query  1059  ------------------TPLYLACKNGNKECIKLLLEAGTN  1082
                               TP+ LA    N E IKLL++ G +
Sbjct  126   QVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVS  167


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 14/105 (13%)

Query  1012  SAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKE  1071
             S +A +NA +K  +     A+ +   E  E  I +  NIN     G+T L +A +N N E
Sbjct  32    SEKAYLNAVEKGDY-----ASVKKSLEEAE--IYFKININCIDPLGRTALLIAIENENLE  84

Query  1072  CIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIPA  1116
              I+LLL      S     G   +H A+    V +++LL+ H+ P+
Sbjct  85    LIELLL------SFNVYVGDALLH-AIRKEVVGAVELLLNHKKPS  122


>gi|1709020|sp|P41594|MGR5_HUMAN  Metabotropic glutamate receptor 5 precursor (mGluR5)
Length=1212

 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 7/82 (8%)

Query  888   AATPGLNQPACSD----SSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLT  943
             A +PG+  P CS       + +PTT+   + I P+ A     GA  +    A+G +   +
Sbjct  1084  APSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARES  1143

Query  944   PLLMSGGPAPLAGRPTLLQQAA  965
             P   + GP   A +P L +  A
Sbjct  1144  P---AAGPEAAAAKPDLEELVA  1162


>gi|3024609|sp|Q15431|SYCP1_HUMAN  Synaptonemal complex protein 1 (SCP-1)
Length=976

 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 73/328 (22%), Positives = 139/328 (42%), Gaps = 66/328 (20%)

Query  251  TPSMIIISRKKEFDVDTLSKSELRMLLSV---MEGELEAR---DLVIEALRELKWFTGIK  304
            T  M +  + ++ D++   K E RML  +    E E + R   + V E L++ +     K
Sbjct  534  TSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCK  593

Query  305  TAKWE---NARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAV  361
              K E   N  RK+V  + +Y    L     AL++    G  + ++  V    ++ LE  
Sbjct  594  LDKSEENCNNLRKQVENKNKYIE-ELQQENKALKKK---GTAESKQLNVYEIKVNKLELE  649

Query  362  MAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKL------AARLEEERGKNK  415
            +   K+    ++      ++ QK++E +K+  + L +E +K       A +L++E  K  
Sbjct  650  LESAKQKFGEIT------DTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRC  703

Query  416  Q----VVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME  471
            Q     ++ L+++ K    K+IEE                          ++++  + + 
Sbjct  704  QHKIAEMVALMEKHKHQYDKIIEERDS-----------------ELGLYKSKEQEQSSLR  746

Query  472  AQMEKQLS-----------EFDTEREQLRAKLNRE-EAHTTDLKEEIDKMRKMI----EQ  515
            A +E +LS           + + ERE+ + KL RE + +T  LKE+ DK  +       +
Sbjct  747  ASLEIELSNLKAELLSVKKQLEIEREE-KEKLKREAKENTATLKEKKDKKTQTFLLETPE  805

Query  516  LKRGSDSKPSLSLPRKTKDRRLVSISVG  543
            +    DSK   ++P +T  R   S+  G
Sbjct  806  IYWKLDSK---AVPSQTVSRNFTSVDHG  830


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 64/293 (21%), Positives = 125/293 (42%), Gaps = 27/293 (9%)

Query  264  DVDTLSKSELRMLLSVMEGELEARDL--VIEALRELKWFTGIKTAKWENARRKEVFIQER  321
            +++   K    +L+ + E E + +DL  ++E  R+       KT K ++   K+   ++ 
Sbjct  260  EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT-KLQSENLKQSIEKQH  318

Query  322  YGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSIL----EAVMAHCKKMQERMSAQLA  377
            +    L D  ++LQR        +E   + T  +  L    E  M    K +   S  + 
Sbjct  319  HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT  378

Query  378  AAES-----------RQKKLEMEKLQLQALEQEHKKLAARLEE--ERGKNKQVVLMLVKE  424
              E+            Q++LE  + QL+ L  E +K ++ LEE  +   NK+V L  +K+
Sbjct  379  EFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKK  438

Query  425  CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSE---F  481
                   ++ E ++ E +    EE K    EL   L A ++   ++E Q+    +    +
Sbjct  439  VLGEKETLLYENKQFEKI---AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY  495

Query  482  DTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKD  534
              E + L+ +L  E+   T+L    +K+    ++L +   S  +L L  + +D
Sbjct  496  SKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQ-ETSDMTLELKNQQED  547


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 37/171 (21%), Positives = 75/171 (43%), Gaps = 36/171 (21%)

Query  366  KKMQERMSAQLAAAESR----QKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLML  421
            KK +    A+L   ES+    +K +E ++  +Q L+  ++K++ +LEE   +NK     L
Sbjct  117  KKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKD----L  172

Query  422  VKE-------CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQM  474
            +KE       C  L       A+K +                  +   E+  + ++   +
Sbjct  173  IKENNATRHLCNLLKETCARSAEKTK------------------KYEYEREETRQVYMDL  214

Query  475  EKQLSEFDTEREQLR--AKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSK  523
               + +  T   +LR  A+ +R E H   LKE+ +K++ + ++ K+  + K
Sbjct  215  NNNIEKMITAHGELRVQAENSRLEMH-FKLKEDYEKIQHLEQEYKKEINDK  264


>gi|30912698|sp|Q8NB25|CF060_HUMAN  Hypothetical protein C6orf60
Length=1020

 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 44/201 (21%), Positives = 84/201 (41%), Gaps = 29/201 (14%)

Query  363  AHCKKMQERMSAQLAAAESRQKKLEMEKLQLQA-LEQEHKKLAARLEEERGKNKQVVLML  421
            AH K ++E       A E+       +K +LQ  LE++H K    LEE++ + +Q +  L
Sbjct  358  AHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENL  417

Query  422  VKECKQLSGKVIEEAQKLED-VMAkleeekkktneleeelSAEKRRSTEME---------  471
             +  +       +E   L+D V    +        +     +++R   E++         
Sbjct  418  KEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKET  477

Query  472  ----AQMEKQLSEFDTEREQLRAKLNREE-------AH------TTDLKEEIDKMRKMIE  514
                  +E +L +   + E+  A +  EE       AH      T +L++E  K+R+ + 
Sbjct  478  KDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL-  536

Query  515  QLKRGSDSKPSLSLPRKTKDR  535
            +L+   D K ++S   + KDR
Sbjct  537  RLQHEEDKKSAMSQLLQLKDR  557


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 34/160 (21%), Positives = 72/160 (45%), Gaps = 5/160 (3%)

Query  360  AVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVL  419
            +++  C+K+Q  ++      +  QK+L+  K    AL  +HK++ + L   R + +Q   
Sbjct  198  SLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQAS  257

Query  420  MLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKR---RSTEMEAQMEK  476
             LV +   +   +++  Q  ++V  K  E +K           E+R   RS       E+
Sbjct  258  DLVLKASHIG--MLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ  315

Query  477  QLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQL  516
            +    + E++   AK  ++E +  +LK    ++ + + QL
Sbjct  316  KQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQL  355


 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 54/288 (18%), Positives = 117/288 (40%), Gaps = 54/288 (18%)

Query  272  ELRMLLSVMEGEL-EARDLVIEALRELKW-----FTGIKTAKWENARRKEVFIQERYGR-  324
            EL+ L S +E E+ +  +   + L EL W        + +    + ++ ++ ++E++ + 
Sbjct  340  ELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKD  399

Query  325  -FNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESR-  382
              NL +    LQ++ E        K V  + L+     + H + M  +    L +AE   
Sbjct  400  KLNLEEDKNQLQQELE------NLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLI  453

Query  383  ----------QKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKV  432
                      Q +L++ K  L+  +     +   LE+ER ++++ +  + +E K    K+
Sbjct  454  ASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKM  513

Query  433  I------------EEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEK----  476
                         +E  KL + +    EE KK+   +     ++ ++   ++  +K    
Sbjct  514  AHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDL  573

Query  477  -------------QLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRK  511
                         QLS+  T  +QL+A+  +E    T   EE+++  +
Sbjct  574  LNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQ  621


>gi|22653668|sp|Q9UIF8|BAZ2B_HUMAN  Bromodomain adjacent to zinc finger domain 2B (hWALp4)
Length=1972

 Score = 33.9 bits (76),  Expect = 0.71
 Identities = 40/177 (22%), Positives = 82/177 (46%), Gaps = 15/177 (8%)

Query  367  KMQERMSAQLAAAESRQKKLEMEKLQLQ-----ALEQEHKKLAARLEEERGKNKQVVLML  421
            K+  ++ AQ  A ++ Q KL + KLQ Q     A E + ++     EE+R + +Q+ +M 
Sbjct  688  KLLRKLQAQEIARQAAQIKL-LRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMK  746

Query  422  VKE-CKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSE  480
             +E  K++    +E+  + + ++   +++K++    +   + ++ +  EM  Q    L  
Sbjct  747  QQEKIKRIQQIRMEKELRAQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKH  806

Query  481  FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRL  537
             + ER +    L +          E  K  +  E+LK+    +  L+  RK + RRL
Sbjct  807  QERERRRQHMMLMK--------AMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRL  855


>gi|46396501|sp|Q9BRK4|LZTS2_HUMAN  Leucine zipper putative tumor suppressor 2 (Protein LAPSER1)
Length=669

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 58/243 (23%), Positives = 101/243 (41%), Gaps = 32/243 (13%)

Query  271  SELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDP  330
            S+  +L  V+EG+L  R+  ++ LR+         +  EN        +ER   +     
Sbjct  320  SDEALLHCVLEGKLRDREAELQQLRD---------SLDENEATMCQAYEERQRHWQRERE  370

Query  331  FLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEK  390
              AL+ D  A A   ++       L  L+      +  QE+   Q   A+  Q++ ++E+
Sbjct  371  --ALREDCAAQAQRAQR----AQQLLQLQVF----QLQQEKRQLQDDFAQLLQEREQLER  420

Query  391  LQLQALEQEHKKLAARLEEERGK--NKQVVLMLVKECKQLSGKVIEEAQKLEDVMA----  444
             +   LE+E ++L  RLEE + +   K   + L+K+  QL     E  QK  +++A    
Sbjct  421  -RCATLEREQRELGPRLEETKWEVCQKSGEISLLKQ--QLKESQAELVQKGSELVALRVA  477

Query  445  ---kleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
                    +           A + R  E+EA   ++L     E EQLR K  + +A    
Sbjct  478  LREARATLRVSEGRARGLQEAARARELELEA-CSQELQRHRQEAEQLREKAGQLDAEAAG  536

Query  502  LKE  504
            L+E
Sbjct  537  LRE  539


>gi|38605068|sp|Q9NSC5|HOME3_HUMAN  Homer protein homolog 3 (Homer-3)
Length=361

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 51/220 (23%), Positives = 86/220 (39%), Gaps = 42/220 (19%)

Query  309  ENARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGD-KEKKPVCTNPLSILEAVMAHCKK  367
            E  R K++  +   G       F ALQ      AG  +E           LEA  A  ++
Sbjct  167  ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER  226

Query  368  MQERMSAQLAAAESRQKKL-EMEKL-------QLQALEQEHKKLAARLEEERGKNKQVVL  419
            +++R++   A A S      E E L       QL+AL Q   +    L+ + G  ++ + 
Sbjct  227  LRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE  286

Query  420  MLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQ---MEK  476
               +E         E  QK++D+                     + R+ E+E Q   ME+
Sbjct  287  AAERE---------ETQQKVQDL---------------------ETRNAELEHQLRAMER  316

Query  477  QLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQL  516
             L E   ERE+ RA++ R          E+ ++R+ + +L
Sbjct  317  SLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL  356


>gi|33301318|sp|Q92614|MY18A_HUMAN  Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule 
associated with JAK3 N-terminus) (MAJN)
Length=2054

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 43/204 (21%), Positives = 88/204 (43%), Gaps = 33/204 (16%)

Query  362   MAHCKKMQERMSAQLAAAESRQKKLEME------------------KLQLQALEQEHKKL  403
             +A  K   E      AAA   +K +E+E                  + QL  L++E  ++
Sbjct  1685  IAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEI  1744

Query  404   AARLEEER-------GKNKQVVLMLVKECKQLSG--KVIEEAQKLEDVMAkleeekkktn  454
               RLEE++        K+K  V    ++  Q++     +EEA K +  + +  +  +   
Sbjct  1745  QNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQV  1804

Query  455   eleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIE  514
             E  E+   +K     + ++ E ++ E +T  E  R ++ R E+  + LKE ++K+ +  +
Sbjct  1805  EFLEQSMVDK----SLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERD  1860

Query  515   Q--LKRGSDSKPSLSLPRKTKDRR  536
             Q       + + +  L R+ +D +
Sbjct  1861  QRIAAENREKEQNKRLQRQLRDTK  1884


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 21/73 (28%), Positives = 37/73 (50%), Gaps = 7/73 (9%)

Query  470   MEAQM-EKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQL------KRGSDS  522
             +E Q+ E+Q+   D E +QLR+KL + E    +L+   D++   I +L      +R +  
Sbjct  1247  IEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGE  1306

Query  523   KPSLSLPRKTKDR  535
               S  L  +T +R
Sbjct  1307  SASQLLDAETAER  1319


 Score = 32.0 bits (71),  Expect = 2.7
 Identities = 40/172 (23%), Positives = 71/172 (41%), Gaps = 31/172 (18%)

Query  358   LEAVMAHCKKMQERMSAQLAAAES-RQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQ  416
             L  + A  K  +E +  Q    +   Q KL +E ++++ + Q H K     +EE  + +Q
Sbjct  1544  LRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLE-MEMERMRQTHSKEMESRDEEVEEARQ  1602

Query  417   VVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEK  476
                   K+ KQ+  ++ EE +  + V+                   EKR      A +  
Sbjct  1603  ---SCQKKLKQMEVQLEEEYEDKQKVL------------------REKRELEGKLATLSD  1641

Query  477   QLSEFDTERE-QLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLS  527
             Q++  D E E +LR  L R +A   D        + M++ LK  + SK  ++
Sbjct  1642  QVNRRDFESEKRLRKDLKRTKALLAD-------AQLMLDHLKNSAPSKREIA  1686


>gi|34582329|sp|Q96BM1|ANKR9_HUMAN  Ankyrin repeat domain protein 9
Length=317

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 15/40 (37%), Positives = 24/40 (60%), Gaps = 0/40 (0%)

Query  1055  DGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPV  1094
             +GG T L++AC+    EC+ LLL  G +  ++   G TP+
Sbjct  157   EGGGTSLHVACELARPECLFLLLGHGASPGLRDGGGLTPL  196


>gi|6685537|sp|Q14152|IF3A_HUMAN  Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 
theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a)
Length=1382

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 44/181 (24%), Positives = 84/181 (46%), Gaps = 21/181 (11%)

Query  366  KKMQERMSAQLAAAESRQKKLEM------EKLQLQALEQE----HKKLAARLEEERGKNK  415
            K+++E    + A  E R K +++      E++    LE+E    HK   +R+ E+R    
Sbjct  702  KRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDR----  757

Query  416  QVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQME  475
             + +M +K  +Q    V EE  KL+    +L EE+    E  +    E+RR T    + E
Sbjct  758  DLFVMRLKAARQ---SVYEE--KLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEE  812

Query  476  KQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDR  535
            ++      E + L+ +  RE A     +EE+ + ++ +++L+     K    L  + ++R
Sbjct  813  EEQRR--AEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERER  870

Query  536  R  536
            R
Sbjct  871  R  871


>gi|117424|sp|P23508|CRCM_HUMAN  Colorectal mutant cancer protein (MCC protein)
Length=829

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 35/141 (24%), Positives = 62/141 (43%), Gaps = 15/141 (10%)

Query  469  EMEAQMEKQLSEFDTEREQLRA-------KLNREEAHTTDLKEEIDKMRKMIEQLKRGSD  521
            E  ++ EK+L+    E E L A       +LNR +A    ++EE D++R+ + +L+    
Sbjct  226  EERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQ  285

Query  522  SKPSL---SLPRKTKDRRLVSISVGTEGTVTRSVACQTDLVTENADHMKKLPLTMPVKPS  578
            S  +    S  R T   R ++ S G   T + S     D+         KL  T     S
Sbjct  286  SVQATGPSSPGRLTSTNRPINPSTGELSTSSSS----NDIPIAKIAERVKLSKTRSESSS  341

Query  579  TGSPLVSANAKGSVCTSATMA  599
            +  P++ +    S+  S+++A
Sbjct  342  SDRPVLGSEI-SSIGVSSSVA  361


>gi|74749769|sp|Q71F56|T240L_HUMAN  Thyroid hormone receptor-associated protein 2 (Thyroid hormone 
receptor-associated protein complex 240 kDa component-like)
Length=2210

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 9/86 (10%)

Query  885   AWPAATPGLNQPACSDSSLVIPTTIAFCSSINPVSASSCRPGASDSLLVTASGWSPSLTP  944
             A P A    N  + S S+    ++ A  SS+ PVS+S+  PG S     ++SG+S S+  
Sbjct  1554  AAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSV--  1611

Query  945   LLMSGGPAPLAGRPTLLQQAAAQGNV  970
                 GG  P  G    +     QGN+
Sbjct  1612  ----GGQNPSTGG---ISADRTQGNI  1630


>gi|13431713|sp|Q9NQX4|MYO5C_HUMAN  Myosin-5C (Myosin Vc)
Length=1742

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 41/169 (24%), Positives = 83/169 (49%), Gaps = 14/169 (8%)

Query  366   KKMQERMSAQLAAAESRQKKLEMEKLQLQA--------LEQEHKKLAARLEEERGKNKQV  417
             K+ ++ +  +LA  +    +LE +K Q+Q         L+++   L  +L ++  K ++ 
Sbjct  948   KRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQ  1007

Query  418   VLMLVKECKQLSGKVIEEAQKL-EDVMAkleeekkktneleeelSAEKRRSTEMEAQMEK  476
              ++L K  +  +    ++ Q L E++ A  +E+ +  + +E E         E+ A++ K
Sbjct  1008  RMLLEKSFELKTQDYEKQIQSLKEEIKALKDEKMQLQHLVEGEHVTSDGLKAEV-ARLSK  1066

Query  477   Q---LSEFDTEREQLRAKLNREEAHTTDLKEEI-DKMRKMIEQLKRGSD  521
             Q   +SEF+ E E L+A+    E H    K E+ +KM ++ +QL    D
Sbjct  1067  QVKTISEFEKEIELLQAQKIDVEKHVQSQKREMREKMSEITKQLLESYD  1115


 Score = 31.2 bits (69),  Expect = 4.6
 Identities = 33/143 (23%), Positives = 61/143 (42%), Gaps = 29/143 (20%)

Query  383   QKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV---------VLMLVKECKQLSGKVI  433
             +K++E    ++  L QE   L     EE   N+ +           M++ + KQ   ++ 
Sbjct  1163  EKEIEALNFKVVHLSQEINHLQKLFREENDINESIRHEVTRLTSENMMIPDFKQQISELE  1222

Query  434   EEAQKLEDVMAkleeekkktneleeelSAEKRRST--EMEAQMEKQLSEFDTEREQLRAK  491
             ++ Q LE               +     AEK +    E+  Q+ +   E  T+R+ L A 
Sbjct  1223  KQKQDLE---------------IRLNEQAEKMKGKLEELSNQLHRSQEEEGTQRKALEA-  1266

Query  492   LNREEAHTTDLKEEIDKMRKMIE  514
               + E HT + ++ IDK+++M E
Sbjct  1267  --QNEIHTKEKEKLIDKIQEMQE  1287


 Score = 30.4 bits (67),  Expect = 7.8
 Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 21/135 (15%)

Query  390   KLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleee  449
             K Q+  LE++ + L  RL E+  K K              GK+ E + +L     +   +
Sbjct  1215  KQQISELEKQKQDLEIRLNEQAEKMK--------------GKLEELSNQLHRSQEEEGTQ  1260

Query  450   kkktneleeelSAEKRRST----EMEAQMEKQLSEFDTERE---QLRAKLNREEAHTTDL  502
             +K      E  + EK +      EM+   +    +F+TE E     R + +R      DL
Sbjct  1261  RKALEAQNEIHTKEKEKLIDKIQEMQEASDHLKKQFETESEVKCNFRQEASRLTLENRDL  1320

Query  503   KEEIDKMRKMIEQLK  517
             +EE+D   ++I++L+
Sbjct  1321  EEELDMKDRVIKKLQ  1335


>gi|51701377|sp|O15083|ERC2_HUMAN  ERC protein 2
Length=957

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 37/152 (24%), Positives = 81/152 (53%), Gaps = 14/152 (9%)

Query  383  QKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQ--KLE  440
            +K  E+E L L+ ++ ++KK+ A L+  +   K+    L++E ++    + + +Q  ++E
Sbjct  745  KKIAELESLTLRHMKDQNKKV-ANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIE  803

Query  441  DVMAkleeekkktneleeelSAEKRRSTEMEAQM-------EKQLSE-FDTEREQLRAKL  492
            ++M  LE+ +++ +  +  L++ ++   E EA +        KQL E  + ++E L A +
Sbjct  804  ELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAI  863

Query  493  NREEAHTTDLKEEIDKMRKMIEQ---LKRGSD  521
            + ++A+   L+    K +K  E+   LKR  D
Sbjct  864  SEKDANIALLELSASKKKKTQEEVMALKREKD  895


>gi|84029396|sp|Q86SQ0|PHLB2_HUMAN  Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)
Length=1253

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 48/238 (20%), Positives = 98/238 (41%), Gaps = 44/238 (18%)

Query  272  ELRMLLSVMEGELEARDLVIEALRELKWFTGIKTAKWENARRKEVFIQERYGRFNLNDPF  331
            EL M  ++++GE ++    +   +E+      K A+ E    K +  ++   +  L+   
Sbjct  621  ELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELE----KNIVGEKTKEKVKLDAER  676

Query  332  LALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKL  391
              L+R  E  +  K +   C  P S+ E +    K+      A L   ES+      E L
Sbjct  677  EKLERLQELYSEQKTQLDNC--PESMREQLQQQLKR-----DADLLDVESKH----FEDL  725

Query  392  QLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekk  451
            + Q LE E     +RL+EE+   + +   L++E  +    ++   +K+            
Sbjct  726  EFQQLEHE-----SRLDEEK---ENLTQQLLREVAEYQRNIVSRKEKI------------  765

Query  452  ktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKM  509
                     SA K+++  +  Q +++   F  E+  L   L RE+ +  +L+++   +
Sbjct  766  ---------SALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSL  814


>gi|51338837|sp|Q9UPQ3|CENG2_HUMAN  Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin 
repeat and pleckstrin homology domains 1) (AGAP1)
Length=857

 Score = 33.5 bits (75),  Expect = 0.92
 Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 0/67 (0%)

Query  1014  EAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECI  1073
             E      + +G T L  A  +G+    +LLI Y  ++      G T L  A +  ++ECI
Sbjct  759   EVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECI  818

Query  1074  KLLLEAG  1080
              +LL+ G
Sbjct  819   DVLLQYG  825


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 16/59 (27%), Positives = 31/59 (52%), Gaps = 0/59 (0%)

Query  1057  GQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLMYHRIP  1115
             G+T L+LAC+ GN    +LL+  G + + +   G T +  A    + + + +L+ +  P
Sbjct  769   GRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCP  827


>gi|14424221|sp|O75154|RFIP3_HUMAN  Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing 
Rab-interacting protein) (Eferin)
Length=756

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 39/175 (22%), Positives = 79/175 (45%), Gaps = 36/175 (20%)

Query  369  QERMSAQLAAAESRQKKLEMEKLQ--LQALEQEHKKLAA----------RLEEERGKNKQ  416
            + R   +L     R+K +E+E LQ  LQ L++E+ +L +          RLEEE+ K   
Sbjct  522  ETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQK---  578

Query  417  VVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEK  476
                L+ E + L+ ++ EE +    +         + +    +   +K  + E+   + K
Sbjct  579  ----LLDEIESLTLRLSEEQENKRRM-------GDRLSHERHQFQRDKEATQELIEDLRK  627

Query  477  QLSEFD---TEREQLRAK---LNREEAHT----TDLKEEIDKMRKMIEQLKRGSD  521
            QL        E EQ R +   +  +E H+    ++L++E+ ++++    LK  ++
Sbjct  628  QLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNE  682


>gi|42558969|sp|Q13136|LIPA1_HUMAN  Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f 
polypeptide-interacting protein alpha-1) (PTPRF-interacting 
protein alpha-1) (LAR-interacting protein 1) (LIP.1)
Length=1202

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 70/319 (21%), Positives = 128/319 (40%), Gaps = 37/319 (11%)

Query  313  RKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSI-LEAVMAHCKKMQER  371
            R++  ++ER    +L+     L+ D +    D  K       L   +   MA  + M+ER
Sbjct  264  REQSQMKERLA--SLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER  321

Query  372  MSAQLAAAESRQKKLEMEKLQLQALEQE--HKKLAARLEEERGKNKQVVLMLVKECKQLS  429
            ++       + Q++          LE E  +K    R  E++ +  Q  L L ++  Q  
Sbjct  322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ--  379

Query  430  GKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRST--EMEAQMEKQLSEFDTEREQ  487
             + + +A+ L +V A+L +     +       AE+R     E   QME QL E + E ++
Sbjct  380  -QTLRKAETLPEVEAELAQRVAALS------KAEERHGNIEERLRQMEAQLEEKNQELQR  432

Query  488  LRAKLNREEAHTTDLKEEIDK--------MRKMIEQLKRGSDSKPSLSLPRKTKDRRLVS  539
             R +    E H   L + +DK        ++  +++     + K SL    ++  ++L  
Sbjct  433  ARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEE  492

Query  540  ISVGTEGTVTRSVACQTDLVTENADHMKKLPLTM-PVKPSTGS------PLVSANAKGSV  592
                 +  V    A + +L     DHM+    ++   +P  GS      P+   +   S 
Sbjct  493  TQHDKDQLVLNIEALRAEL-----DHMRLRGASLHHGRPHLGSVPDFRFPMADGHT-DSY  546

Query  593  CTSATMARPGIDRQASYGD  611
             TSA + RP   R A+  D
Sbjct  547  STSAVLRRPQKGRLAALRD  565


>gi|12643336|sp|Q9UI32|GLSL_HUMAN  Glutaminase liver isoform, mitochondrial precursor (GLS) (L-glutamine 
amidohydrolase) (L-glutaminase)
Length=602

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 2/113 (1%)

Query  995   LYSAAKNGHTDCVRLLLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAA  1054
             L  AA +G    +R    +   +   D +  T L  AAA+GH E V+ LI        A 
Sbjct  490   LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK  549

Query  1055  D-GGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSL  1106
             D  G  PL  A +  + E +KLL +   + ++  T        A+   N++S+
Sbjct  550   DRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAE-ALSKENLESM  601


>gi|47605999|sp|Q13464|ROCK1_HUMAN  Rho-associated protein kinase 1 (Rho-associated, coiled-coil-containing 
protein kinase 1) (p160 ROCK-1) (p160ROCK)
Length=1354

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 35/137 (25%), Positives = 62/137 (45%), Gaps = 17/137 (12%)

Query  383  QKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEDV  442
            Q+KLE      + +E E K L  +LE+E  K     L+L  E K  + +  +  + LE  
Sbjct  752  QQKLEHLTGNKERMEDEVKNLTLQLEQESNKR----LLLQNELKTQAFEA-DNLKGLEKQ  806

Query  443  MAkleeekkktneleeelSAEKRRSTEME-AQMEKQLSEFDTEREQLRAKLNREEAHTTD  501
            M +                 E +R  E E AQ+ KQ    + +  +L+ +L  E+  +T 
Sbjct  807  MKQEINTL-----------LEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTL  855

Query  502  LKEEIDKMRKMIEQLKR  518
             K ++ ++++ IE+  R
Sbjct  856  YKTQVKELKEEIEEKNR  872


 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 25/94 (26%), Positives = 49/94 (52%), Gaps = 4/94 (4%)

Query  346   EKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQK-KLEMEKLQLQAL---EQEHK  401
             EK+   +N  +  E  +   + ++ +   +LA   +R+  K++ +K   Q L   E+E++
Sbjct  976   EKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENR  1035

Query  402   KLAARLEEERGKNKQVVLMLVKECKQLSGKVIEE  435
             KL   L +ER K  Q+V+   KE   +  +++EE
Sbjct  1036  KLQLELNQEREKFNQMVVKHQKELNDMQAQLVEE  1069


 Score = 32.7 bits (73),  Expect = 1.6
 Identities = 46/185 (24%), Positives = 86/185 (46%), Gaps = 18/185 (9%)

Query  361  VMAHCKKMQERMSAQLAA---AESRQKKLEMEKL-----QLQALEQEHKKLAARLEEERG  412
            ++ + K   ++   QL A   AE R +  + E +     ++ +L++E K L   LE+  G
Sbjct  591  ILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEG  650

Query  413  KNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeel-----SAEKRRS  467
            + K+   ML    K+ +   I+   KL+ +  +LE+E  +    +  L     S E+ +S
Sbjct  651  ERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKS  710

Query  468  TEMEAQMEKQLSEFDTEREQLRAKLNREEAHTT----DLKEEIDKMRKMIEQLKRGSDSK  523
              M  +MEK+L E    RE+   ++ + E   +    DLK+   K+  +    +R  D  
Sbjct  711  VAM-CEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEV  769

Query  524  PSLSL  528
             +L+L
Sbjct  770  KNLTL  774


 Score = 31.6 bits (70),  Expect = 3.5
 Identities = 41/172 (23%), Positives = 82/172 (47%), Gaps = 35/172 (20%)

Query  369   QERMSAQLAAAESRQKKLEMEKLQLQA----LEQEHKKLAAR--------------LEEE  410
             +E ++ QL  AE++ +  ++ +  L+     L QE KK A+R              LEE 
Sbjct  885   KETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEA  944

Query  411   RGKNKQVVLMLVKECKQLSGKV--IEEAQKLEDVMAkleeekkktneleeelSAEKRRST  468
                  + + +L +E ++L+ K+   EE  KLE           +      + + EK  +T
Sbjct  945   NSMLTKDIEILRRENEELTEKMKKAEEEYKLEK----------EEEISNLKAAFEKNINT  994

Query  469   E--MEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKR  518
             E  ++ Q   +L+E    ++    K++R++A+T DL+++  + RK+  +L +
Sbjct  995   ERTLKTQAVNKLAEIMNRKD---FKIDRKKANTQDLRKKEKENRKLQLELNQ  1043


 Score = 30.8 bits (68),  Expect = 6.0
 Identities = 32/146 (21%), Positives = 74/146 (50%), Gaps = 3/146 (2%)

Query  380  ESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKL  439
            ES   ++E EK+ LQ    E+++ A +  E+R   +  V  L  + + L  KV + +Q  
Sbjct  478  ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLK-KVSQNSQLA  536

Query  440  EDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHT  499
             + +++L+++ ++ N+L    S    R  +   +M K +S+ ++   +L+ +    E   
Sbjct  537  NEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSK  596

Query  500  TDLKEEIDKMRKMI--EQLKRGSDSK  523
            +   ++  +++ ++  E+  RG DS+
Sbjct  597  SQTDKDYYQLQAILEAERRDRGHDSE  622


>gi|13431923|sp|O95359|TACC2_HUMAN  Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) 
(AZU-1)
Length=1026

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 35/150 (23%), Positives = 69/150 (46%), Gaps = 17/150 (11%)

Query  370   ERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLS  429
             E+  AQ+   E R+K +  + +Q   LE+E       L +     K +  +  +  K   
Sbjct  868   EKTIAQMIEDEQREKSVSHQTVQQLVLEKEQA-----LADLNSVEKSLADLFRRYEKMK-  921

Query  430   GKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTEREQLR  489
              +V+E  +K E+V+ +  +E             E++R   ++   E++L   + E  Q+R
Sbjct  922   -EVLEGFRKNEEVLKRCAQEYLSRV------KKEEQRYQALKVHAEEKLDRANAEIAQVR  974

Query  490   AKLNREE-AHTTDLKEE---IDKMRKMIEQ  515
              K  +E+ AH   L++E   +D + + +EQ
Sbjct  975   GKAQQEQAAHQASLRKEQLRVDALERTLEQ  1004


>gi|464541|sp|P35241|RADI_HUMAN  Radixin
Length=583

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 32/153 (20%), Positives = 67/153 (43%), Gaps = 27/153 (17%)

Query  358  LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEE------ER  411
            ++ + A  ++ + +   + A  E+ +KK E+ + + + +E+E ++L  RL++      + 
Sbjct  302  VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA  361

Query  412  GKNKQVVLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEME  471
             K  +       E  Q   +  EEA++LE                      E+R + E +
Sbjct  362  QKELEEQTRKALELDQERKRAKEEAERLE---------------------KERRAAEEAK  400

Query  472  AQMEKQLSEFDTEREQLRAKLNREEAHTTDLKE  504
            + + KQ ++    +EQL A+L    A    L+E
Sbjct  401  SAIAKQAADQMKNQEQLAAELAEFTAKIALLEE  433


>gi|2497520|sp|Q12840|KINN_HUMAN  Neuronal kinesin heavy chain (NKHC) (Kinesin heavy chain isoform 
5A) (Kinesin heavy chain neuron-specific 1)
Length=1032

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 42/208 (20%), Positives = 88/208 (42%), Gaps = 19/208 (9%)

Query  379  AESRQKKLEMEKLQLQALEQEHKKLAARLEEER-GKNKQVVLMLVKECKQLSGKVIEEA-  436
            AE  +KK E EK + +A ++   KL A L   R G+N      L  E   L  ++ EE  
Sbjct  339  AEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEEAALGAELCEETP  398

Query  437  ----------------QKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSE  480
                            QK E+ + +L ++    ++   + S    +  +     E+ L  
Sbjct  399  VNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVS  458

Query  481  FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRGSDSKPSLSLPRKTKDRRLVSI  540
               + E+++ +L+  ++     K+E+ ++ + +E+L    D K S  +  K++  +L+  
Sbjct  459  TRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQK-SQEVEEKSQQNQLLVD  517

Query  541  SVGTEGTVTRSVACQTDLVTENADHMKK  568
             +  +     S+  +   + E + H +K
Sbjct  518  ELSQKVATMLSLESELQRLQEVSGHQRK  545


 Score = 32.3 bits (72),  Expect = 2.1
 Identities = 45/198 (22%), Positives = 83/198 (41%), Gaps = 36/198 (18%)

Query  379  AESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQK  438
            A+  +K LE   LQ+++  + H +  ARL +E  + ++     + E K L+ K+  E +K
Sbjct  692  ADEVKKALE---LQMESHREAHHRQLARLRDEINEKQKT----IDELKDLNQKLQLELEK  744

Query  439  LEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQLSEFDTER-EQLRAKLNREEA  497
            L+                      EK +S E E   + Q   F  ER EQ +  L   E 
Sbjct  745  LQ-------------------ADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDLKGLEE  785

Query  498  HTTDLKEEIDKMRKMIEQ-----LKRGSDSKPSLSLPRKTKDRRLVSISVGTEGTVTRSV  552
                  + +  +RK+  Q     +K+ ++ +P  S    ++ +++  +    E  + +  
Sbjct  786  TVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFL----ENNLEQLT  841

Query  553  ACQTDLVTENADHMKKLP  570
                 LV +NAD   +LP
Sbjct  842  KVHKQLVRDNADLRCELP  859


>gi|57015279|sp|O14578|CTRO_HUMAN  Citron Rho-interacting kinase (CRIK) (Rho-interacting, serine/threonine-protein 
kinase 21)
Length=2027

 Score = 33.1 bits (74),  Expect = 1.2
 Identities = 51/213 (23%), Positives = 96/213 (45%), Gaps = 29/213 (13%)

Query  358   LEAVMAHCKKMQERMSAQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQV  417
             LEA+     + + +  A  +     + + E    +LQ +    K+  AR ++   +++QV
Sbjct  1029  LEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQV  1088

Query  418   VLMLVKECKQLSGKVIEEAQKLEDVMAkleeekkktneleeelSAEKRRSTEMEAQMEKQ  477
             V + VKE K      +++A K + + A+   +K            +K    EM A+  +Q
Sbjct  1089  VELAVKEHK-AEILALQQALKEQKLKAESLSDKLNDL-------EKKHAMLEMNARSLQQ  1140

Query  478   LSEFDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRG----SDSKPSLSLPRKTK  533
               + +TERE L+ +L  E+A    L++++D  +  I +L +G     D    L   R   
Sbjct  1141  --KLETERE-LKQRLLEEQA---KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDL  1194

Query  534   DRRLVSI-------SVGTEGTVTRSVACQTDLV  559
             + +L +I        V  EGT+++    QT L+
Sbjct  1195  EYQLENIQVLYSHEKVKMEGTISQ----QTKLI  1223






  Database: Non-redundant SwissProt sequences
    Posted date:  Mar 28, 2006  2:14 AM
  Number of letters in database: 7,471,329
  Number of sequences in database:  13,755
Lambda     K      H
   0.315    0.130    0.388 
Gapped
Lambda     K      H
   0.267   0.0410    0.140 
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 13755
Number of Hits to DB: 3395
Number of extensions: 124
Number of successful extensions: 0
Number of sequences better than 10: 0
Number of HSP's better than 10 without gapping: 0
Number of HSP's gapped: 0
Number of HSP's successfully gapped: 0
Length of query: 1991
Length of database: 7471329
Length adjustment: 111
Effective length of query: 1880
Effective length of database: 7471329
Effective search space: 14046098520
Effective search space used: 11175705120
T: 11
A: 40
X1: 16 (7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 67 (30.4 bits)







 


 
Format
  


 


 
Show
  Graphical OverviewLinkoutSequence RetrievalNCBI-giAlignmentPSSMBioseq in HTMLPlain textASN.1XMLformat


 


 

  CDS feature


 


 

  Masking CharacterX for protein, n for nucleotideLower Case
Masking ColorBlackGreyRed



 


 
Number of:
  Descriptions01050100250500
Alignments01050100250500



 


 
Alignment view
  PairwisePairwise with identitiesquery-anchored with identitiesquery-anchored without identitiesflat query-anchored with identitiesflat query-anchored without identitiesHit Table


 


 
Format for PSI-BLAST
  with inclusion threshold:


 


 
Limit results by entrez query
   or select from:All organismsViruses [ORGN]Archaea [ORGN]Bacteria [ORGN]Eukaryota [ORGN]Viridiplantae [ORGN]Fungi [ORGN]Metazoa [ORGN]Arthropoda [ORGN]Vertebrata [ORGN]Mammalia [ORGN]Rodentia [ORGN]Primates [ORGN]-------------------Aeropyrum pernix [ORGN]Aquifex aeolicus [ORGN]Arabidopsis thaliana [ORGN]Bacillus subtilis [ORGN]Bos taurus [ORGN]Caenorhabditis elegans [ORGN]Canis familiaris[ORGN]Danio rerio [ORGN]Dictyostelium discoideum [ORGN]Drosophila melanogaster [ORGN]Escherichia coli [ORGN]Gallus gallus [ORGN]Homo sapiens [ORGN]Human immunodeficiency virus type 1 [ORGN]Methanococcus jannaschii [ORGN]Mus musculus [ORGN]Oryctolagus cuniculus [ORGN]Oryza sativa [ORGN]Ovis aries [ORGN]Plasmodium falciparum [ORGN]Rattus norvegicus [ORGN]Saccharomyces cerevisiae [ORGN]Schizosaccharomyces pombe [ORGN]Xenopus tropicalis[ORGN]Simian immunodeficiency virus [ORGN]Sus scrofa[ORGN]Synechocystis PCC6803 [ORGN]Takifugu rubripes [ORGN]Xenopus laevis [ORGN]Zea mays [ORGN]


 


 
Expect value range:
    







 or