>gi|139750|sp|P09544|WNT2_HUMAN Wnt-2 protein precursor (IRP protein) (Int-1-related protein)
Length=360
Score = 440 bits (1132), Expect = 4e-124
Identities = 235/340 (69%), Positives = 245/340 (72%), Gaps = 41/340 (12%)
Query 22 EVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFR 81
EVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFR
Sbjct 22 EVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFR 81
Query 82 QHRWNCNTLDRDHSLFGRVLLRSKSPAFTQPYGSPLMHSSLTPSSKTLLIFYCILFHQKF 141
QHRWNCNTLDRDHSLFGRVLLRS S+ Y I
Sbjct 82 QHRWNCNTLDRDHSLFGRVLLRS---------------------SRESAFVYAIS----- 115
Query 142 VQLGVIVPVLQIPKALKKGG-KFTNLDHKKSGGRAGPK----WAHRAAQQHPQNPDLHIC 196
GV V I +A +G K + D KK G K W + N D I
Sbjct 116 -SAGV---VFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCS-----DNIDYGI- 165
Query 197 QVCLQLAACRHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMA 256
+ + + A L+ +R KAVKRFLKQECKCHGVSGSCTLRTCWLAMA
Sbjct 166 KFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMA 225
Query 257 DFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAG 316
DFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAG
Sbjct 226 DFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAG 285
Query 317 SLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCG 356
SLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCG
Sbjct 286 SLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCG 325
>gi|14424481|sp|Q93097|WNT2B_HUMAN Wnt-2b protein precursor (Wnt-13)
Length=391
Score = 207 bits (528), Expect = 4e-54
Identities = 91/143 (63%), Positives = 115/143 (80%), Gaps = 0/143 (0%)
Query 213 AERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGA 272
A L+ +R AV+RFLK ECKCHGVSGSCTLRTCW A++DFR+TGDYL R+Y+GA
Sbjct 213 ARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGA 272
Query 273 IQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGM 332
+QV+ QDG FT A + +++ T+ DLVYF+NSPDYC+ D+ AGSLGTAGRVC+ TS+G
Sbjct 273 VQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGT 332
Query 333 DSCEVMCCGRGYDTSHVTRMTKC 355
D CE+MCCGRGYDT+ VTR+T+C
Sbjct 333 DGCEIMCCGRGYDTTRVTRVTQC 355
Score = 133 bits (335), Expect = 1e-31
Identities = 56/86 (65%), Positives = 70/86 (81%), Gaps = 2/86 (2%)
Query 23 VNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQ 82
V++SWWY+ A G +RV+CDN+PGLVS QRQLC R+PD+MR++ +G EW ECQHQFR
Sbjct 56 VDTSWWYIGALG--ARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRH 113
Query 83 HRWNCNTLDRDHSLFGRVLLRSKSPA 108
HRWNC TLDRDH++FGRV+LRS A
Sbjct 114 HRWNCTTLDRDHTVFGRVMLRSSREA 139
>gi|731157|sp|P41221|WNT5A_HUMAN Wnt-5a protein precursor
Length=365
Score = 196 bits (497), Expect = 2e-50
Identities = 118/341 (34%), Positives = 172/341 (50%), Gaps = 39/341 (11%)
Query 25 SSWWYMRATGG---------SSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAE 75
+SWW + ++ +C + GL Q++LCH + D M+ I +G E
Sbjct 29 NSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKE 88
Query 76 CQHQFRQHRWNCNTLDRDHSLFGRVL-LRSKSPAFTQPYGSPLMHSSLTPSSKTLLIFYC 134
CQ+QFR RWNC+T+D S+FGRV+ + S+ AFT + + ++++ + + + C
Sbjct 89 CQYQFRHRRWNCSTVDNT-SVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTC 147
Query 135 ILFHQKFVQLGVIVPVLQIPKALKKGGKFTNLDHKKSGGRAGPKWAHRAAQQHPQNPDLH 194
+ +P+ GG N+D+ G R ++ ++ +H
Sbjct 148 GCSRAARPK--------DLPRDWLWGGCGDNIDY---GYRFAKEFVDARERER-----IH 191
Query 195 ICQVCLQLAACRHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLA 254
A + ++ L A R + V CKCHGVSGSC+L+TCWL
Sbjct 192 --------AKGSYESARILMNLHNNEAGR---RTVYNLADVACKCHGVSGSCSLKTCWLQ 240
Query 255 MADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDRE 314
+ADFRK GD L KY+ A + +N G V N RF PT DLVY + SPDYC+R+
Sbjct 241 LADFRKVGDALKEKYDSAAAMRLNSRGKLVQV-NSRFNSPTTQDLVYIDPSPDYCVRNES 299
Query 315 AGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKC 355
GSLGT GR+CN TS GMD CE+MCCGRGYD + +C
Sbjct 300 TGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERC 340
>gi|20532427|sp|Q9H1J7|WNT5B_HUMAN Wnt-5b protein precursor
Length=359
Score = 192 bits (488), Expect = 2e-49
Identities = 118/340 (34%), Positives = 176/340 (51%), Gaps = 38/340 (11%)
Query 25 SSWWYMRATGGS--------SRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAEC 76
+SWW + ++ +C +PGL QR+LC + + M I +G EC
Sbjct 24 NSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAYIGEGAKTGIKEC 83
Query 77 QHQFRQHRWNCNTLDRDHSLFGRVL-LRSKSPAFTQPYGSPLMHSSLTPSSKTLLIFYCI 135
QHQFRQ RWNC+T D + S+FGRV+ + S+ AFT + + ++++ + + + C
Sbjct 84 QHQFRQRRWNCSTAD-NASVFGRVMQIGSRETAFTHAVSAAGVVNAISRACREGELSTCG 142
Query 136 LFHQKFVQLGVIVPVLQIPKALKKGGKFTNLDHKKSGGRAGPKWAHRAAQQHPQNPDLHI 195
+ +P+ GG N+++ G R ++ A++ +N
Sbjct 143 CSRTARPK--------DLPRDWLWGGCGDNVEY---GYRFAKEFVD--AREREKN----- 184
Query 196 CQVCLQLAACRHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAM 255
A +V L A R +AV + CKCHGVSGSC+L+TCWL +
Sbjct 185 ------FAKGSEEQGRVLMNLQNNEAGR---RAVYKMADVACKCHGVSGSCSLKTCWLQL 235
Query 256 ADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREA 315
A+FRK GD L KY+ A + + + G + N RF +PT DLVY + SPDYC+R+
Sbjct 236 AEFRKVGDRLKEKYDSAAAMRVTRKGR-LELVNSRFTQPTPEDLVYVDPSPDYCLRNEST 294
Query 316 GSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKC 355
GSLGT GR+CN TS GMD CE+MCCGRGY+ ++ +C
Sbjct 295 GSLGTQGRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERC 334
>gi|14424477|sp|P56703|WNT3_HUMAN Wnt-3 proto-oncogene protein precursor
Length=355
Score = 177 bits (450), Expect = 5e-45
Identities = 111/343 (32%), Positives = 167/343 (48%), Gaps = 53/343 (15%)
Query 28 WYMRATG------GSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFR 81
W+ A G GS ++C ++PGLV Q + C + ++M ++++GV ECQHQFR
Sbjct 26 WWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFR 85
Query 82 QHRWNCNTLDRDHSLFGRVLLRS-KSPAFTQPYGSPLMHSSLTPSSK--TLLIFYCILFH 138
RWNC T+D ++FG VL ++ + AF S + ++T S T I C
Sbjct 86 GRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCD--- 142
Query 139 QKFVQLGVIVPVLQIPKALKKGGKFTNLDHKKSGGRAGPKWAHRAAQQHPQNPDLHICQV 198
H K G KW + ++ D + V
Sbjct 143 ----------------------------SHHKGPPGEGWKWGGCS-----EDADFGVL-V 168
Query 199 CLQLAACRHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADF 258
+ A R P A + K + + + +CKCHG+SGSC ++TCW A DF
Sbjct 169 SREFADARENRPD-ARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDF 227
Query 259 RKTGDYLWRKYNGAIQVVM--NQDGTGFT----VANERFKKPTKNDLVYFENSPDYCIRD 312
R GD+L KY+ A ++V+ +++ G+ FK PT+ DLVY+ENSP++C +
Sbjct 228 RAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPN 287
Query 313 REAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKC 355
E GS GT R CN+TS G+D C+++CCGRG++T R KC
Sbjct 288 PETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKC 330
>gi|20532424|sp|P56704|WNT3A_HUMAN Wnt-3a protein precursor
Length=352
Score = 171 bits (432), Expect = 6e-43
Identities = 106/343 (30%), Positives = 168/343 (48%), Gaps = 53/343 (15%)
Query 28 WYMRATG------GSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFR 81
W+ A G GS ++C ++PGLV Q + C + ++M ++++G+ ECQHQFR
Sbjct 23 WWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFR 82
Query 82 QHRWNCNTLDRDHSLFGRVLLRS-KSPAFTQPYGSPLMHSSLTPSSK--TLLIFYCILFH 138
RWNC T+ ++FG VL ++ + AF S + ++T S T I C H
Sbjct 83 GRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRH 142
Query 139 QKFVQLGVIVPVLQIPKALKKGGKFTNLDHKKSGGRAGPKWAHRAAQQHPQNPDLHICQV 198
Q K K GG +++ GG ++A A + P
Sbjct 143 QG-----------SPGKGWKWGGCSEDIEF---GGMVSREFAD-ARENRPD--------- 178
Query 199 CLQLAACRHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADF 258
A + + + +A+ + +CKCHG+SGSC ++TCW + DF
Sbjct 179 --------------ARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDF 224
Query 259 RKTGDYLWRKYNGAIQVVM--NQDGTGFTVANER----FKKPTKNDLVYFENSPDYCIRD 312
R GD+L KY+ A ++V+ +++ G+ FK PT+ DLVY+E SP++C +
Sbjct 225 RAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPN 284
Query 313 REAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKC 355
E GS GT R CN++S G+D C+++CCGRG++ R KC
Sbjct 285 PETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKC 327
>gi|20532426|sp|P56706|WNT7B_HUMAN Wnt-7b protein precursor
Length=349
Score = 168 bits (425), Expect = 4e-42
Identities = 105/331 (31%), Positives = 157/331 (47%), Gaps = 52/331 (15%)
Query 37 SRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSL 96
+ ++C+ +PGL QR +C PD + I +G ECQ+QFR RWNC+ L + ++
Sbjct 34 ANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALG-EKTV 92
Query 97 FGRVL-LRSKSPAFTQPYGSPLMHSSLTPSSKTLLIFYCILFHQKFVQLGVIVPVLQIPK 155
FG+ L + S+ AFT + + ++T + + C +K
Sbjct 93 FGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREK--------------- 137
Query 156 ALKKGGKFTNLDHKKSGG-----RAGPKWAHRAAQQHPQNPDLHICQVCLQLAACRHCCP 210
G + + K GG R G ++ R +
Sbjct 138 ----QGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKN------------------ 175
Query 211 QVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYN 270
A RL+ + K ++ ++ ECKCHGVSGSCT +TCW + FR+ G L KYN
Sbjct 176 --ARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYN 233
Query 271 GAIQVVMNQDG-----TGFTVANER-FKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRV 324
A+QV + + T + R ++KP + DLVY E SP+YC D GS+GT GR+
Sbjct 234 AAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRL 293
Query 325 CNLTSRGMDSCEVMCCGRGYDTSHVTRMTKC 355
CN TS G D C+ MCCGRGY+T T++ +C
Sbjct 294 CNRTSPGADGCDTMCCGRGYNTHQYTKVWQC 324
>gi|2501663|sp|O00755|WNT7A_HUMAN Wnt-7a protein precursor
Length=349
Score = 155 bits (392), Expect = 2e-38
Identities = 103/324 (31%), Positives = 151/324 (46%), Gaps = 42/324 (12%)
Query 39 VMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFG 98
++C+ +PGL QR +C PD + I +G ECQ QFR RWNC+ L + ++FG
Sbjct 36 IICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALG-ERTVFG 94
Query 99 RVL-LRSKSPAFTQPYGSPLMHSSLTPSSKTLLIFYCILFHQKFVQLGVIVPVLQIPKAL 157
+ L + S+ AFT + + ++T + H G
Sbjct 95 KELKVGSRDGAFTYAIIAAGVAHAITAACT----------HGNLSDCGC---------DK 135
Query 158 KKGGKFTNLDHKKSGGRAGPKWAHRAAQQHPQNPDLHICQVCLQLAACRHCCPQVAERLL 217
+K G++ H+ G KW +A D+ ++ Q A L+
Sbjct 136 EKQGQY----HRDEGW----KWGGCSA-------DIRYGIGFAKVFVDAREIKQNARTLM 180
Query 218 QKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVV- 276
+ K ++ +K ECKCHGVSGSCT +TCW + FR+ G L KYN A+ V
Sbjct 181 NLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEP 240
Query 277 ----MNQDGTGFTVANE-RFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRG 331
N+ T + ++KP DLVY E SP+YC D GS+GT GR CN T+
Sbjct 241 VRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQ 300
Query 332 MDSCEVMCCGRGYDTSHVTRMTKC 355
C++MCCGRGY+T R+ +C
Sbjct 301 ASGCDLMCCGRGYNTHQYARVWQC 324
>gi|12643875|sp|Q9UBV4|WNT16_HUMAN Wnt-16 protein precursor
Length=365
Score = 147 bits (370), Expect = 9e-36
Identities = 104/341 (30%), Positives = 152/341 (44%), Gaps = 39/341 (11%)
Query 24 NSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQH 83
N W + + G ++ C N+P L S Q++LC R P ++ +I +G EC QFR
Sbjct 30 NWMWLGIASFGVPEKLGCANLP-LNSRQKELCKRKPYLLPSIREGARLGIQECGSQFRHE 88
Query 84 RWNCNTLDRDHSLFGRVLLRSKSPAFTQPYG-SPLMHSSLTPSSKTLLIFYCILFHQKFV 142
RWNC + A T P G SPL L+ +K Y ++
Sbjct 89 RWNCMIT---------------AAATTAPMGASPLFGYELSSGTKETAFIYAVM------ 127
Query 143 QLGVIVPVLQIPKALKKGGKFTNLDHK---KSGGRAGPKWAHRAAQQHPQNPDLHICQVC 199
G++ V + A G T ++GG A W H + +
Sbjct 128 AAGLVHSVTRSCSA----GNMTECSCDTTLQNGGSASEGW-HWGGCSDDVQYGMWFSRKF 182
Query 200 LQLAACRHCCPQ----VAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAM 255
L + +A L A R +AV + + +C+CHGVSGSC ++TCW M
Sbjct 183 LDFPIGNTTGKENKVLLAMNLHNNEAGR---QAVAKLMSVDCRCHGVSGSCAVKTCWKTM 239
Query 256 ADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPT-KNDLVYFENSPDYCIRDRE 314
+ F K G L KY +IQ+ ++ K P K+DL+Y SP+YC+ D++
Sbjct 240 SSFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHKDDLLYVNKSPNYCVEDKK 299
Query 315 AGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKC 355
G GT GR CN TS G D C ++CCGRGY+T V + +C
Sbjct 300 LGIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERC 340
>gi|20532419|sp|O00744|WN10B_HUMAN Wnt-10b protein precursor (Wnt-12)
Length=389
Score = 146 bits (369), Expect = 1e-35
Identities = 100/325 (30%), Positives = 153/325 (47%), Gaps = 8/325 (2%)
Query 36 SSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRD-- 93
++ +C + GL Q LC R+PDV + QG+ ECQHQ R RWNC+ L+
Sbjct 43 TANTVCLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGR 102
Query 94 ---HSLFGRVLLRSKSPAFTQPYGSPLMHSSLTPSSKTLLIFYCILFHQKFVQLGVIVPV 150
HS + R + +F+ + +MH+ T S L+ + Q + +
Sbjct 103 LPHHSAILKRGFRESAFSFSM-LAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKL 161
Query 151 LQIPKALKKGGKFTNLDHKKSGGRAGPKWAHRAAQQHPQNPDLHICQVCLQLAACRHCCP 210
LQ+ +AL +G F + G + + N D+ + + P
Sbjct 162 LQL-QALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAP 220
Query 211 QVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYN 270
+ + ++ +R + V LK++CKCHG SGSC +TCW A +FR G L +
Sbjct 221 RDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLG 280
Query 271 GAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSR 330
AI + + +G R ++ +LVYFE SPD+C RD GS GT GR CN TSR
Sbjct 281 RAIFIDTHNRNSGAFQPRLRPRR-LSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSR 339
Query 331 GMDSCEVMCCGRGYDTSHVTRMTKC 355
+D C +CCGRG++ TR+ +C
Sbjct 340 LLDGCGSLCCGRGHNVLRQTRVERC 364
>gi|20532425|sp|P56705|WNT4_HUMAN Wnt-4 protein precursor
Length=351
Score = 134 bits (338), Expect = 4e-32
Identities = 61/131 (46%), Positives = 85/131 (64%), Gaps = 2/131 (1%)
Query 227 KAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTV 286
KA+ ++ ECKCHGVSGSC ++TCW A+ FR+ G L K++GA +V + G+ +
Sbjct 196 KAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRAL 255
Query 287 A--NERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGY 344
N +FK T DLVY E SPD+C +D +G LGT GR CN TS+ +D CE++CCGRG+
Sbjct 256 VPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGF 315
Query 345 DTSHVTRMTKC 355
T+ V +C
Sbjct 316 HTAQVELAERC 326
Score = 61.6 bits (148), Expect = 5e-10
Identities = 31/88 (35%), Positives = 48/88 (54%), Gaps = 5/88 (5%)
Query 25 SSWWYMRATGG----SSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQF 80
S+W Y+ S C+ + GL+ Q Q+C R+ +VM ++ +G ECQ+QF
Sbjct 23 SNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRRGAQLAIEECQYQF 82
Query 81 RQHRWNCNTLDRDHSLFGRVLLRSKSPA 108
R RWNC+TLD +FG+V+ + A
Sbjct 83 RNRRWNCSTLD-SLPVFGKVVTQGTREA 109
>gi|139743|sp|P04628|WNT1_HUMAN Wnt-1 proto-oncogene protein precursor
Length=370
Score = 121 bits (303), Expect = 5e-28
Identities = 57/134 (42%), Positives = 79/134 (58%), Gaps = 11/134 (8%)
Query 233 LKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERF- 291
++QECKCHG+SGSCT+RTCW+ + R GD L +++GA +V+ G+ E
Sbjct 214 MRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLR 273
Query 292 --------KKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRG 343
K P+ +DLVYFE SP++C G+ GTAGR CN +S +D CE++CCGRG
Sbjct 274 LEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRG 333
Query 344 Y--DTSHVTRMTKC 355
+ T VT C
Sbjct 334 HRTRTQRVTERCNC 347
Score = 50.4 bits (119), Expect = 1e-06
Identities = 29/92 (31%), Positives = 47/92 (51%), Gaps = 13/92 (14%)
Query 24 NSS--WWYMRATGGSSRVMCDN----------VPGLVSSQRQLCHRHPDVMRAISQGVAE 71
NSS WW + S+ ++ D+ + L QR+L ++P ++ ++S G+
Sbjct 29 NSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQS 88
Query 72 WTAECQHQFRQHRWNCNTLDRDHSLFGRVLLR 103
EC+ QFR RWNC T H LFG+++ R
Sbjct 89 AVRECKWQFRNRRWNCPTAPGPH-LFGKIVNR 119
>gi|14424016|sp|Q9Y6F9|WNT6_HUMAN Wnt-6 protein precursor
Length=365
Score = 119 bits (299), Expect = 1e-27
Identities = 53/128 (41%), Positives = 75/128 (58%), Gaps = 0/128 (0%)
Query 228 AVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVA 287
AV+ + ECKCHG+SGSC LRTCW + FR+ G L +++GA +V+ DG A
Sbjct 213 AVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPA 272
Query 288 NERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTS 347
K P + DL+Y +SPD+C +R GS GT GR CN ++ + C+++CCGRG+
Sbjct 273 VRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQE 332
Query 348 HVTRMTKC 355
V C
Sbjct 333 SVQLEENC 340
Score = 50.4 bits (119), Expect = 1e-06
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 12/84 (14%)
Query 23 VNSSWWYMRATGGSSRVM-----CDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQ 77
V WW + GS VM C L Q +LC P+V+ +++G ECQ
Sbjct 22 VGGLWWAV----GSPLVMDPTSICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQ 77
Query 78 HQFRQHRWNCNTLDRDHSLFGRVL 101
QFR RWNC++ + FGR+L
Sbjct 78 FQFRFRRWNCSSHSK---AFGRIL 98
>gi|20532421|sp|O14905|WNT9B_HUMAN Wnt-9b protein precursor (Wnt-15) (Wnt-14b)
Length=357
Score = 115 bits (288), Expect = 3e-26
Identities = 97/330 (29%), Positives = 134/330 (40%), Gaps = 68/330 (20%)
Query 32 ATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLD 91
A GG+ CD + L Q+QLC R P + + ECQ QFR RWNC+
Sbjct 46 AQGGAHLKQCDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEG 104
Query 92 RDHSLFGRVLLRSKSPAFTQPYGSPLMHSSLTPSSKTLLIFYCILFHQKFVQLGVIVPVL 151
R G + K AF S + +L + + C P L
Sbjct 105 RT----GLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS---------PGL 151
Query 152 QIPKALKKGGKFTNLDHKKS------GGRAGPKWAHRAAQQHPQNPDLHICQVCLQLAAC 205
+ +A + G NL + G + G K A H + +
Sbjct 152 ESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGI------------ 199
Query 206 RHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYL 265
KAVK L+ CKCHGVSGSC +RTCW ++ FR+TG L
Sbjct 200 ---------------------KAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVL 238
Query 266 WRKYNGAIQV-VMNQDGTG----FTVANE----RFKKPTKNDLVYFENSPDYCIRDREAG 316
+Y+ A++V + G + A + + P DLVY E+SP +C +
Sbjct 239 KLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKY-- 296
Query 317 SLGTAGRVCNLTSRGMDSCEVMCCGRGYDT 346
S GTAGRVC+ + SC +CCGRGYDT
Sbjct 297 SPGTAGRVCSREA----SCSSLCCGRGYDT 322
>gi|20532422|sp|O96014|WNT11_HUMAN Wnt-11 protein precursor
Length=354
Score = 115 bits (287), Expect = 4e-26
Identities = 59/147 (40%), Positives = 88/147 (59%), Gaps = 4/147 (2%)
Query 213 AERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGA 272
A +L++ S +A++ L+ +CKCHGVSGSC++RTCW + + + L +Y A
Sbjct 185 ANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTRYLSA 244
Query 273 IQVVMNQDGTG-FTVANERFKKPTKN-DLVYFENSPDYCIRDREAGSLGTAGRVCNLTSR 330
+VV GT V + +P K+ +LVY ++SPD+C+++ + GS GT R CN TS
Sbjct 245 TKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKTSN 304
Query 331 GMDSCEVMCCGRGYD--TSHVTRMTKC 355
G DSC++MCCGRGY+ T V C
Sbjct 305 GSDSCDLMCCGRGYNPYTDRVVERCHC 331
Score = 43.1 bits (100), Expect = 2e-04
Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 0/51 (0%)
Query 41 CDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLD 91
C + GLVS+Q QLC + ++M + E C+ F RWNC++++
Sbjct 45 CKQLEGLVSAQVQLCRSNLELMHTVVHAAREVMKACRRAFADMRWNCSSIE 95
>gi|66774217|sp|Q93098|WNT8B_HUMAN Wnt-8b protein precursor
Length=351
Score = 108 bits (270), Expect = 3e-24
Identities = 86/306 (28%), Positives = 129/306 (42%), Gaps = 52/306 (16%)
Query 64 AISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSKSPAFTQPYGSPLMHSSLT 123
+++ G EC++QF RWNC S G + ++ AF S + +LT
Sbjct 42 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLT 101
Query 124 PSSKTLLIFYCILFHQKFVQLGVIVPVLQIPKALKKGGKFTNL--DHKKSGGRAGPKWAH 181
+ C L G F N D ++G G W
Sbjct 102 RN--------CSL------------------------GDFDNCGCDDSRNGQLGGQGWLW 129
Query 182 RAAQQHPQNPDLHICQVCLQLAACRHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHG 241
+ + Q L + + A L A R KAVK +K+ CKCHG
Sbjct 130 GGCSDNVGFGEAISKQFVDALETGQDA--RAAMNLHNNEAGR---KAVKGTMKRTCKCHG 184
Query 242 VSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVAN-----ERFKKPTK 296
VSGSCT +TCWL + +FR+ G +L KY+ A++V + Q G G + A + F+ +
Sbjct 185 VSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQ-GAGNSAAGRGAIADTFRSIST 243
Query 297 NDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMD-----SCEVMC--CGRGYDTSHV 349
+LV+ E+SPDYC+ ++ G LGT GR C R + SC +C CG +
Sbjct 244 RELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRALGRWERRSCRRLCGDCGLAVEERRA 303
Query 350 TRMTKC 355
++ C
Sbjct 304 ETVSSC 309
>gi|20532420|sp|O14904|WNT9A_HUMAN Wnt-9a protein precursor (Wnt-14)
Length=365
Score = 106 bits (265), Expect = 1e-23
Identities = 95/330 (28%), Positives = 139/330 (42%), Gaps = 62/330 (18%)
Query 41 CDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRV 100
CD + L QR++C R P V + + V+ ECQ QFR RWNC R + +
Sbjct 59 CDRLK-LERKQRRMCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRA---SL 114
Query 101 LLRS-KSPAFTQPYGSPLMHSSLTPSSKTLLIFYCILFHQKFVQLGVIVPVLQIPKALKK 159
L R K AF S + +L + + C P L+ +A +
Sbjct 115 LKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDE---------APDLENREAWQW 165
Query 160 GGKFTNLDHKKSGGRAGPKWAHRAAQQHPQNPDLHICQVCLQLAACRHCCPQVAERLLQK 219
GG NL K S R+++ D H V +
Sbjct 166 GGCGDNL--KYSSKFVKEFLGRRSSKDLRARVDFHNNLVGV------------------- 204
Query 220 PASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQ 279
K +K ++ CKCHGVSGSCT+RTCW +A F + G +L KY A++V
Sbjct 205 -------KVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTT 257
Query 280 D---GTGFTVANERFKK---------PTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNL 327
+ G ++ R + P +LV+ ++SP +C+ R S GTAGR C+
Sbjct 258 NEAAGEAGAISPPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGR--FSPGTAGRRCHR 315
Query 328 TSRGMDSCEVMCCGRGYDTSH--VTRMTKC 355
+CE +CCGRG++T VTR +C
Sbjct 316 EK----NCESICCGRGHNTQSRVVTRPCQC 341
>gi|14424011|sp|Q9GZT5|WN10A_HUMAN Wnt-10a protein precursor
Length=417
Score = 106 bits (264), Expect = 2e-23
Identities = 54/141 (38%), Positives = 74/141 (52%), Gaps = 12/141 (8%)
Query 227 KAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQV-VMNQDGTGFT 285
+AV ++++CKCHG SGSC L+TCW +FR G L +++ A + N++G
Sbjct 252 QAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNGGQLE 311
Query 286 VANERFKKPTKN-----------DLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDS 334
P DLVYFE SPD+C R+ S GT GR+CN +S G D
Sbjct 312 PGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDG 371
Query 335 CEVMCCGRGYDTSHVTRMTKC 355
C MCCGRG++ TR +C
Sbjct 372 CGSMCCGRGHNILRQTRSERC 392
Score = 61.2 bits (147), Expect = 6e-10
Identities = 25/56 (44%), Positives = 36/56 (64%), Gaps = 0/56 (0%)
Query 36 SSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLD 91
++ +C +PGL Q ++C RHPDV + QG+ ECQHQFR RWNC++L+
Sbjct 56 NANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLE 111
>gi|14424012|sp|Q9H1J5|WNT8A_HUMAN Wnt-8a protein precursor (Wnt-8d)
Length=355
Score = 102 bits (255), Expect = 2e-22
Identities = 52/137 (37%), Positives = 75/137 (54%), Gaps = 7/137 (5%)
Query 213 AERLLQKPASRDRDKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGA 272
A L+ +R AV+ +K+ CKCHG+SGSC+++TCWL +A+FR+ GDYL KY+ A
Sbjct 156 ARALMNLHNNRAGRLAVRATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQA 215
Query 273 IQVVMNQ-------DGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVC 325
+++ M++ G V E F + +L++ E SPDYC + G GT GR C
Sbjct 216 LKIEMDKRQLRAGNSAEGHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGREC 275
Query 326 NLTSRGMDSCEVMCCGR 342
S E CGR
Sbjct 276 LQNSHNTSRWERRSCGR 292
>gi|121743|sp|P20936|RASA1_HUMAN Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP)
(Ras p21 protein activator) (p120GAP) (RasGAP)
Length=1047
Score = 30.8 bits (68), Expect = 0.91
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 1/57 (1%)
Query 76 CQHQFRQHRWNCNTLDRDHSLFGRVLLRSKSPAFTQPYGSPLMHSSLTP-SSKTLLI 131
C + QH+W NT R + G V LR PA P ++ S +P +++TL++
Sbjct 876 CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLIL 932
>gi|85700433|sp|Q7Z333|SETX_HUMAN Probable helicase senataxin (SEN1 homolog)
Length=2677
Score = 30.0 bits (66), Expect = 1.5
Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 3/46 (6%)
Query 51 QRQLCHRHPDVMRAISQGVAEWT-AECQHQFRQHRWNCNTLDRDHS 95
+ +LCHR RA S+G E +E H R RW+ TL+++ S
Sbjct 2626 EEELCHRRE--ARAFSEGEQEKCGSETHHTRRNSRWDKRTLEQEDS 2669
>gi|50403688|sp|Q8IXZ3|SP8_HUMAN Transcription factor Sp8 (Specificity protein 8)
Length=508
Score = 29.6 bits (65), Expect = 2.0
Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 3/42 (7%)
Query 309 CIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGY-DTSHV 349
C +EA LG AG +L +G+ SC + CG+ Y TSH+
Sbjct 352 CPNCQEAERLGPAG--ASLRRKGLHSCHIPGCGKVYGKTSHL 391
>gi|50400672|sp|Q9NQ79|CRAC1_HUMAN Cartilage acidic protein 1 precursor (Chondrocyte expressed protein
68 kDa) (CEP-68) (ASPIC)
Length=661
Score = 29.3 bits (64), Expect = 2.6
Identities = 16/59 (27%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query 275 VVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMD 333
VV +G + +R +K N V +SP Y +RDR+ ++G C++ G +
Sbjct 72 VVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDRQGNAIGVT--ACDIDGDGRE 128
>gi|22002033|sp|O95260|ATE1_HUMAN Arginyl-tRNA--protein transferase 1 (R-transferase 1) (Arginyltransferase
1) (Arginine-tRNA--protein transferase 1)
Length=518
Score = 28.9 bits (63), Expect = 3.4
Identities = 26/85 (30%), Positives = 35/85 (41%), Gaps = 10/85 (11%)
Query 170 KSGGRAGPKWAHRAAQQHPQNPDL------HICQVCLQLAACRHCCPQ--VAERLLQKPA 221
+SG R+ WAH Q Q DL + + + CCPQ + R LQ
Sbjct 29 ESGSRSNGMWAHSMTVQDYQ--DLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQP 86
Query 222 SRDRDKAVKRFLKQECKCHGVSGSC 246
S+ K +K+ LK K GSC
Sbjct 87 SKSHKKVLKKMLKFLAKGEVPKGSC 111
>gi|85700439|sp|Q9H5U6|ZCHC4_HUMAN Zinc finger CCHC domain-containing protein 4
Length=513
Score = 28.5 bits (62), Expect = 4.5
Identities = 18/66 (27%), Positives = 25/66 (37%), Gaps = 6/66 (9%)
Query 177 PKWAHRAAQQHPQNPD------LHICQVCLQLAACRHCCPQVAERLLQKPASRDRDKAVK 230
P W H + H PD H C +C +L R CP +A A R + +
Sbjct 420 PSWIHCSICNHCAVPDHSCEGPKHGCFICGELDHKRSTCPNIATSKRANKAVRKQKQRKS 479
Query 231 RFLKQE 236
+K E
Sbjct 480 NKMKME 485
>gi|131436|sp|P08118|MSMB_HUMAN Beta-microseminoprotein precursor (Prostate secreted seminal
plasma protein) (Prostate secretory protein PSP94) (PSP-94)
(Seminal plasma beta-inhibin) (Immunoglobulin binding factor)
(IGBF) (PN44)
Length=114
Score = 28.5 bits (62), Expect = 4.5
Identities = 18/68 (26%), Positives = 27/68 (39%), Gaps = 7/68 (10%)
Query 186 QHPQNPDLHI--CQVCLQLAACRHCCPQVAERLLQKPASRDRDKAVKRFLKQECKCHGVS 243
+HP N + C+ C CC L+ P D+D + F K++CK V
Sbjct 45 KHPINSEWQTDNCETCTCYETEISCCT-----LVSTPVGYDKDNCQRIFKKEDCKYIVVE 99
Query 244 GSCTLRTC 251
+TC
Sbjct 100 KKDPKKTC 107
>gi|23396507|sp|Q9BQT9|CSTN3_HUMAN Calsyntenin-3 precursor
Length=956
Score = 28.5 bits (62), Expect = 4.5
Identities = 21/74 (28%), Positives = 34/74 (45%), Gaps = 19/74 (25%)
Query 120 SSLTPSSKTLLIFYCILFHQKFVQLGVIVPVLQIPKALKKGGKFTNLDHKKSGGRAGPKW 179
+S+ PS+ TL+I C+ F V LG++ + +L H++ G GP
Sbjct 841 NSMIPSAATLIIVVCVGFLVLMVVLGLV--------------RIHSL-HRRVSGAGGPP- 884
Query 180 AHRAAQQHPQNPDL 193
A P++PDL
Sbjct 885 ---GASSDPKDPDL 895
Database: Non-redundant SwissProt sequences
Posted date: Mar 15, 2006 2:23 AM
Number of letters in database: 7,391,856
Number of sequences in database: 13,628
Lambda K H
0.324 0.135 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 13628
Number of Hits to DB: 1741
Number of extensions: 65
Number of successful extensions: 0
Number of sequences better than 10: 0
Number of HSP's better than 10 without gapping: 0
Number of HSP's gapped: 0
Number of HSP's successfully gapped: 0
Length of query: 378
Length of database: 7391856
Length adjustment: 98
Effective length of query: 280
Effective length of database: 7391856
Effective search space: 2069719680
Effective search space used: 1695767360
T: 11
A: 40
X1: 15 (7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (20.0 bits)
S2: 60 (27.7 bits)