>gi|17380320|sp|Q9UGI8|TES_HUMAN Testin (TESS)
Length=421
Score = 770 bits (1987), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%), Gaps = 0/358 (0%)
Query 136 MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEED 195
MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEED
Sbjct 1 MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEED 60
Query 196 RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQ 255
RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQ
Sbjct 61 RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQ 120
Query 256 ALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVK 315
ALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVK
Sbjct 121 ALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVK 180
Query 316 KYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCK 375
KYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCK
Sbjct 181 KYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCK 240
Query 376 LSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPR 435
LSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPR
Sbjct 241 LSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPR 300
Query 436 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA 493
CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA
Sbjct 301 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA 358
>gi|20978521|sp|Q9NZU5|LMCD1_HUMAN LIM and cysteine-rich domains protein 1 (Dyxin)
Length=365
Score = 386 bits (992), Expect = 1e-107
Identities = 183/359 (50%), Positives = 244/359 (67%), Gaps = 8/359 (2%)
Query 134 VNMDLENKVKKMGLGHEQGF-GAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSN 192
V DL VKKM LG Q G CL CK C GFE H WRKIC++CKC QE+H +
Sbjct 4 VAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDL 63
Query 193 EEDRKVGKLFEDTKYTTLIAKLKS-DGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPP 251
E+DRK+G+L D+KY+TL A++K DGI +YKRN MI+TNP+A K+ + +T+TYEWAPP
Sbjct 64 EDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPP 123
Query 252 VQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEME 311
Q L QYM+++PKEKQPV G+EGA YR++QL QLP +DQDPS+C L E+K ME
Sbjct 124 GVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLME 183
Query 312 QFVKKYKSEALGVGDVKLPCE--MDAQGPKQMNIPGGDRSTPAAV-GAMEDKSAEHKRTQ 368
+FVK+YKSEALGVG+V LP + + + KQ P G +T A G++ D S K +
Sbjct 184 EFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPS---KEVE 240
Query 369 YSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHY 428
Y C CK + P +Y++RAGY+K WHP CFVC+ C E LVD+IYFWK+ +CGRHY
Sbjct 241 YVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHY 300
Query 429 CDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPC 487
C+S +PRC+GCDE+IF+ +Y + E+ WH KHF C C+ +L+G Y++ + +C C
Sbjct 301 CESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTC 359
>gi|22096354|sp|O43900|LMO6_HUMAN LIM domain only protein 6 (Triple LIM domain protein 6)
Length=615
Score = 234 bits (598), Expect = 5e-62
Identities = 126/340 (37%), Positives = 173/340 (50%), Gaps = 55/340 (16%)
Query 154 GAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAK 213
G PC C+E+C GF LH WRKIC++CKC +EEH V + ++ + +
Sbjct 24 GQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVHAVPVDLERI------------MCR 71
Query 214 LKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVA 273
L SD ++R+ + + A + Y W PP Q+ LP++K P
Sbjct 72 LISD----FQRHSISDDDSGCASEE-------YAWVPPGLKPEQVYQFFSCLPEDKVPYV 120
Query 274 GSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEM 333
S G +YR KQL QLP HD + C L E KE+ F ++ K E LG G V++
Sbjct 121 NSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIVRI---- 176
Query 334 DAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYD 393
P + T C C + GD A++A RAG
Sbjct 177 ----------------FPVTI------------TGAICEECGKQIGGGDIAVFASRAGLG 208
Query 394 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 453
WHP CFVC+TC ELLVD+IYF+ K+YCGRH+ + +PRC CDE+IFS E T+AE
Sbjct 209 ACWHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLRPRCQACDEIIFSPECTEAEG 268
Query 454 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA 493
++WH+ HFCCF+C++ L G+ YVM +P C CY HA
Sbjct 269 RHWHMDHFCCFECEASLGGQRYVMRQSRPHCCACYEARHA 308
>gi|59800163|sp|Q96MT3|PRIC1_HUMAN Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein
1)
Length=831
Score = 204 bits (519), Expect = 7e-53
Identities = 99/248 (39%), Positives = 141/248 (56%), Gaps = 32/248 (12%)
Query 246 YEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPR 305
Y W PP + Y LP+EK P S G ++R KQL QLP HD + C LS
Sbjct 33 YAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEE 92
Query 306 EVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHK 365
E KE++ F + K EALG G +KL R+ AV
Sbjct 93 EKKELQVFSAQRKKEALGRGTIKLL----------------SRAVMHAV----------- 125
Query 366 RTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 425
C C L + G+ A++A RAG WHP+CFVC TC+ELLVD+IYF+++ K++CG
Sbjct 126 -----CEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCG 180
Query 426 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 485
RH+ + KPRC+ CDE+IF++E T+AE ++WH+KHFCC +C+++L G+ Y+M + +P C
Sbjct 181 RHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCC 240
Query 486 PCYVKNHA 493
C+ +A
Sbjct 241 GCFESLYA 248
>gi|85701877|sp|Q7Z3G6|PRIC2_HUMAN Prickle-like protein 2
Length=844
Score = 204 bits (518), Expect = 1e-52
Identities = 97/248 (39%), Positives = 138/248 (55%), Gaps = 32/248 (12%)
Query 246 YEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPR 305
Y W PP QY LP+EK P S G + R KQL QLP HD + C+ L
Sbjct 37 YAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQLPPHDNEVRYCNSLDEE 96
Query 306 EVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHK 365
E +E++ F + K E LG G+V+ P + + G
Sbjct 97 EKRELKLFSSQRKRENLGRGNVR---------PFPVTMTGA------------------- 128
Query 366 RTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 425
C C + GD A++A RAG+ WHP CFVC+ C+ELLVD+IYF+++ K+YCG
Sbjct 129 ----ICEQCGGQINGGDIAVFASRAGHGVCWHPPCFVCTVCNELLVDLIYFYQDGKIYCG 184
Query 426 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 485
RH+ + KPRCA CDE+IF++E T+AE ++WH+KHFCCF+C+++L G+ Y+M +P C
Sbjct 185 RHHAECLKPRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCC 244
Query 486 PCYVKNHA 493
C+ +A
Sbjct 245 HCFESLYA 252
Score = 31.6 bits (70), Expect = 0.86
Identities = 30/125 (24%), Positives = 46/125 (36%), Gaps = 34/125 (27%)
Query 356 AMEDKSAEHKRTQYSCYCC----------KLSMKEGDP-------AIYAE---------- 388
A E AE + +CC + MKEG P ++YAE
Sbjct 204 ADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIG 263
Query 389 ----RAGYD-KLWHPA--CFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDE 441
+ YD + WH CF C+ C + L+ + K +++C R E P + +
Sbjct 264 IDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSD 323
Query 442 LIFSN 446
F N
Sbjct 324 SAFQN 328
>gi|2497681|sp|Q14192|FHL2_HUMAN Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle
LIM-protein 3) (SLIM 3) (LIM-domain protein DRAL)
Length=279
Score = 68.2 bits (165), Expect = 8e-12
Identities = 31/102 (30%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 451
D+ WH ACF CS C LVD + K ++L C Y + +C C + I +
Sbjct 58 DRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEY 117
Query 452 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA 493
+ +WH F C C + + ++ +++ C PCY K HA
Sbjct 118 KGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159
Score = 64.7 bits (156), Expect = 9e-11
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 9/126 (7%)
Query 365 KRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYC 424
K+ C CK+ + G Y E+ WH CFVC+ C + L + +++ YC
Sbjct 156 KQHAMQCVQCKMPITTGG-VTYREQP-----WHKECFVCTACRKQLSGQRFTARDDFAYC 209
Query 425 GRHYCDSEKPRCAGCDELIF---SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDK 481
+CD +CAGC I +Y E + WH F C C L G ++ D
Sbjct 210 LNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD 269
Query 482 PVCKPC 487
+C C
Sbjct 270 ILCPDC 275
Score = 51.6 bits (122), Expect = 8e-07
Identities = 32/128 (25%), Positives = 54/128 (42%), Gaps = 7/128 (5%)
Query 368 QYSCYC--CKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 425
+YS C CK ++ G + + + WH CF+C C + + + K+ + +C
Sbjct 96 EYSSKCQECKKTIMPGTRKMEYKGSS----WHETCFICHRCQQPIGTKSFIPKDNQNFCV 151
Query 426 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 485
Y +C C I + T E Q WH + F C C L+G+ + +D C
Sbjct 152 PCYEKQHAMQCVQCKMPITTGGVTYRE-QPWHKECFVCTACRKQLSGQRFTARDDFAYCL 210
Query 486 PCYVKNHA 493
C+ +A
Sbjct 211 NCFCDLYA 218
Score = 39.3 bits (90), Expect = 0.004
Identities = 20/88 (22%), Positives = 37/88 (42%), Gaps = 13/88 (14%)
Query 419 NEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA-------------ENQNWHLKHFCCFD 465
NE L+ ++ E P C C E +F+N + ++++WH F C
Sbjct 11 NESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQ 70
Query 466 CDSILAGEIYVMVNDKPVCKPCYVKNHA 493
C + L + + D+ +C CY ++
Sbjct 71 CRNSLVDKPFAAKEDQLLCTDCYSNEYS 98
>gi|27735219|sp|P49023|PAXI_HUMAN Paxillin
Length=591
Score = 67.4 bits (163), Expect = 1e-11
Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 1/96 (1%)
Query 395 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 454
LWHP CFVC C V+ +F + + YC HY + C+GC + I T A +
Sbjct 494 LWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCIT-AMAK 552
Query 455 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 490
+H +HF C C L + NDKP C+ C++K
Sbjct 553 KFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 588
Score = 62.4 bits (150), Expect = 5e-10
Identities = 34/118 (28%), Positives = 48/118 (40%), Gaps = 7/118 (5%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCD 430
CY C P + D+ WHP F C+ C + K+ K YC + Y D
Sbjct 417 CYYCN------GPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFD 470
Query 431 SEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
P+C GC I N Y A N WH + F C +C + + + +P C+ Y
Sbjct 471 MFAPKCGGCARAILEN-YISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHY 527
Score = 60.5 bits (145), Expect = 2e-09
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 1/95 (1%)
Query 394 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 453
K WHP FVC+ C E + +F ++ + YC + Y + PRC C+ I T A +
Sbjct 375 KTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVT-ALD 433
Query 454 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
+ WH +HF C C + E + + K C+ Y
Sbjct 434 RTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDY 468
Score = 31.2 bits (69), Expect = 1.1
Identities = 13/53 (24%), Positives = 23/53 (43%), Gaps = 1/53 (1%)
Query 436 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
C C + I + + A + WH +HF C C + + + +P C+ Y
Sbjct 358 CGACKKPI-AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDY 409
>gi|59800384|sp|Q13642|FHL1_HUMAN Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle
LIM-protein 1) (SLIM 1) (SLIM)
Length=323
Score = 65.5 bits (158), Expect = 5e-11
Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query 395 LWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQ 454
+WH CF CS C +++ +F K E YC + C C++ I S T ++Q
Sbjct 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY-QDQ 179
Query 455 NWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
WH F C C LAG+ + V D+ C CY
Sbjct 180 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 213
Score = 53.1 bits (126), Expect = 3e-07
Identities = 21/97 (21%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC-DELIFSNEYTQA 451
++ WH CF C+ C L + + K+ K+ C + + P+C GC ++ ++ +
Sbjct 58 NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 117
Query 452 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
+ WH F C +C ++ + + C C+
Sbjct 118 KGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCH 154
Score = 40.4 bits (93), Expect = 0.002
Identities = 17/47 (36%), Positives = 24/47 (51%), Gaps = 0/47 (0%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGC 439
D+ WH CFVC TC + L + ++ YC Y + +CAGC
Sbjct 178 DQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGC 224
Score = 32.7 bits (73), Expect = 0.38
Identities = 23/88 (26%), Positives = 37/88 (42%), Gaps = 1/88 (1%)
Query 401 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSN-EYTQAENQNWHLK 459
F C C + L Y K+ C + + C C + I ++ + +N+ WH
Sbjct 5 FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64
Query 460 HFCCFDCDSILAGEIYVMVNDKPVCKPC 487
F C C LA E +V ++K +C C
Sbjct 65 CFRCAKCLHPLANETFVAKDNKILCNKC 92
>gi|8134557|sp|O60711|LPXN_HUMAN Leupaxin
Length=386
Score = 65.5 bits (158), Expect = 5e-11
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query 396 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 455
WHP FVC+ C E + +F ++ YC Y PRCA C I T A NQ
Sbjct 171 WHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLT-AMNQT 229
Query 456 WHLKHFCCFDCDSILAGEIYVMVNDKPVCK 485
WH +HF C C + E + + KP C+
Sbjct 230 WHPEHFFCSHCGEVFGAEGFHEKDKKPYCR 259
Score = 64.7 bits (156), Expect = 9e-11
Identities = 33/108 (30%), Positives = 49/108 (45%), Gaps = 1/108 (0%)
Query 383 PAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDEL 442
P + + D +WHP CFVC C +F + + +C HY C GC +
Sbjct 276 PVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQP 335
Query 443 IFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 490
I + A +H +HF C C + L+ I+ NDK C+PC+ K
Sbjct 336 I-TGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNK 382
Score = 60.1 bits (144), Expect = 2e-09
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 1/96 (1%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 452
++ WHP F CS C E+ + K++K YC + + P+C GC+ + N Y A
Sbjct 227 NQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLEN-YLSAM 285
Query 453 NQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
+ WH + F C DC + + + ++ +P C+ Y
Sbjct 286 DTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHY 321
Score = 30.4 bits (67), Expect = 1.9
Identities = 13/34 (38%), Positives = 18/34 (52%), Gaps = 1/34 (2%)
Query 433 KPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDC 466
K CA C + I + + A Q+WH +HF C C
Sbjct 149 KGHCASCQKPI-AGKVIHALGQSWHPEHFVCTHC 181
>gi|27923801|sp|Q8TE12|LMX1A_HUMAN LIM homeobox transcription factor 1 alpha (LIM/homeobox protein
LMX1A) (LIM-homeobox protein 1.1) (LMX-1.1)
Length=382
Score = 65.1 bits (157), Expect = 7e-11
Identities = 34/100 (34%), Positives = 53/100 (53%), Gaps = 3/100 (3%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT-QA 451
D WH C C++C E L + F++++KLYC Y +C GC E I NE+ +A
Sbjct 52 DSFWHEQCVQCASCKEPL-ETTCFYRDKKLYCKYDYEKLFAVKCGGCFEAIAPNEFVMRA 110
Query 452 ENQNWHLKHFCCFDCD-SILAGEIYVMVNDKPVCKPCYVK 490
+ +HL FCC C+ + G+ +V+ + +CK Y K
Sbjct 111 QKSVYHLSCFCCCVCERQLQKGDEFVLKEGQLLCKGDYEK 150
>gi|83288256|sp|O75112|LDB3_HUMAN LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif
protein) (Protein cypher)
Length=727
Score = 62.8 bits (151), Expect = 3e-10
Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 5/114 (4%)
Query 373 CCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSE 432
C K + K ++A R + WH CFVC+ C + + ++ ++ + YC + Y +
Sbjct 610 CAKCNTKIMGEVMHALR----QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
Query 433 KPRCAGCD-ELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 485
+C GCD + +++ +A WH F C C L G+ + D+P+CK
Sbjct 666 STKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
Score = 60.5 bits (145), Expect = 2e-09
Identities = 29/94 (30%), Positives = 41/94 (43%), Gaps = 1/94 (1%)
Query 396 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 455
WHP F C+ C L D+ + + +YC R Y P CA C+ I E A Q
Sbjct 570 WHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIM-GEVMHALRQT 628
Query 456 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYV 489
WH F C C ++ M + +P C+ Y+
Sbjct 629 WHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYI 662
Score = 40.8 bits (94), Expect = 0.001
Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 4/57 (7%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 427
C+ C ++ GD I E G+ WH CF+C+ CH L ++ K ++ C +H
Sbjct 669 CHGCDFPVEAGDKFI--EALGHT--WHDTCFICAVCHVNLEGQPFYSKKDRPLCKKH 721
Score = 36.6 bits (83), Expect = 0.027
Identities = 18/63 (28%), Positives = 28/63 (44%), Gaps = 1/63 (1%)
Query 426 RHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 485
R S P C C+ +I + A ++WH + F C C + LA +V + C+
Sbjct 541 RFPASSRTPLCGHCNNVI-RGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCE 599
Query 486 PCY 488
CY
Sbjct 600 RCY 602
>gi|8489005|sp|Q13643|FHL3_HUMAN Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle
LIM-protein 2) (SLIM 2)
Length=280
Score = 62.0 bits (149), Expect = 6e-10
Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 3/98 (3%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF---SNEYT 449
D WHP C VC+ C L + ++E YC + + P+C+ C I +Y
Sbjct 178 DLPWHPKCLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYV 237
Query 450 QAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPC 487
E+++WH F C C + L G+ +V D+ +C+ C
Sbjct 238 SFEDRHWHHNCFTCDRCSNSLVGQGFVPDGDQVLCQGC 275
Score = 61.6 bits (148), Expect = 8e-10
Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 1/102 (0%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 451
D+ +H CF C C L D + ++ +L C YC + +C+ C E + + +
Sbjct 58 DRHFHEGCFRCCRCQRSLADEPFTRQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEY 117
Query 452 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA 493
Q WH F C C+ L +V C PCY N A
Sbjct 118 GGQTWHEHCFLCIGCEQPLGSRPFVPDKGAHYCVPCYENNFA 159
Score = 53.5 bits (127), Expect = 2e-07
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Query 396 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 455
WH CF+C C + L + YC Y ++ PRCA C + + T +
Sbjct 122 WHEHCFLCIGCEQPLGSRPFVPDKGAHYCVPCYENNFAPRCARCTKTLTQGGLTYRDLP- 180
Query 456 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
WH K C C + LAG+ + ++ P C C+
Sbjct 181 WHPKCLVCTGCQTPLAGQQFTSRDEDPYCVACF 213
Score = 41.6 bits (96), Expect = 8e-04
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 1/89 (1%)
Query 401 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELI-FSNEYTQAENQNWHLK 459
F C+ C+E L Y + YC Y ++ CA C +LI + E++++H
Sbjct 5 FDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEG 64
Query 460 HFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
F C C LA E + + + +C CY
Sbjct 65 CFRCCRCQRSLADEPFTRQDSELLCNDCY 93
>gi|8247930|sp|O60663|LMX1B_HUMAN LIM homeobox transcription factor 1 beta (LIM/homeobox protein
LMX1B) (LIM-homeobox protein 1.2) (LMX-1.2)
Length=379
Score = 60.1 bits (144), Expect = 2e-09
Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 3/97 (3%)
Query 396 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT-QAENQ 454
WH C C+ C + L YF ++ KLYC + Y +C+GC E I E+ +A
Sbjct 53 WHEECLQCAACQQALTTSCYF-RDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALEC 111
Query 455 NWHLKHFCCFDCD-SILAGEIYVMVNDKPVCKPCYVK 490
+HL FCC C+ + G+ +V+ + +CK Y K
Sbjct 112 VYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEK 148
>gi|47605572|sp|Q96HC4|PDLI5_HUMAN PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ
and LIM domains protein)
Length=596
Score = 58.5 bits (140), Expect = 7e-09
Identities = 38/143 (26%), Positives = 65/143 (45%), Gaps = 9/143 (6%)
Query 348 RSTPAAVGAMEDKSAEHKRTQYSCY----CCKLSMKEGDPAIYAERAGYDKLWHPACFVC 403
++T A +G +E+K A + Y + C + K I A + + WH +CFVC
Sbjct 450 KNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALK----QTWHVSCFVC 505
Query 404 STCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNE-YTQAENQNWHLKHFC 462
C + + + ++ ++ + YC Y C GC+ I + + + +A WH F
Sbjct 506 VACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFV 565
Query 463 CFDCDSILAGEIYVMVNDKPVCK 485
C C L G+ + DKP+CK
Sbjct 566 CSVCCESLEGQTFFSKKDKPLCK 588
Score = 52.0 bits (123), Expect = 6e-07
Identities = 26/95 (27%), Positives = 39/95 (41%), Gaps = 1/95 (1%)
Query 394 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 453
K WHP F C+ C + + + + LYC Y P C C I E A
Sbjct 437 KSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKIL-GEVINALK 495
Query 454 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
Q WH+ F C C + ++ + + +P C+ Y
Sbjct 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY 530
Score = 47.8 bits (112), Expect = 1e-05
Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 427
C+ C+ ++ GD ++ E GY WH CFVCS C E L +F K +K C +H
Sbjct 538 CHGCEFPIEAGD--MFLEALGYT--WHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
Score = 33.9 bits (76), Expect = 0.17
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 1/57 (1%)
Query 434 PRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 490
P CA C+++I + A ++WH + F C C + +A +V C+ CY K
Sbjct 418 PMCAHCNQVI-RGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEK 473
>gi|74752914|sp|Q9NR12|PDLI7_HUMAN PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP)
(Protein enigma)
Length=457
Score = 57.8 bits (138), Expect = 1e-08
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 5/119 (4%)
Query 368 QYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 427
+Y+ C K K ++A + WH CF C+ C + + ++ + YC R
Sbjct 336 RYAPSCAKCKKKITGEIMHALKM----TWHVHCFTCAACKTPIRNRAFYMEEGVPYCERD 391
Query 428 YCDSEKPRCAGCD-ELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK 485
Y +C GCD ++ + + +A +WH F C C L G+ + D+P+CK
Sbjct 392 YEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 450
Score = 52.4 bits (124), Expect = 5e-07
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query 396 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 455
+HP FVCS C ++L + +F + ++C Y P CA C + I + E A
Sbjct 301 YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKI-TGEIMHALKMT 359
Query 456 WHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 490
WH+ F C C + + + M P C+ Y K
Sbjct 360 WHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEK 394
Score = 36.6 bits (83), Expect = 0.027
Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 4/57 (7%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 427
C+ C + GD + E G+ WH CFVC+ C L ++ K ++ C H
Sbjct 400 CHGCDFKIDAGDR--FLEALGFS--WHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 452
>gi|18266876|sp|P48059|PINC_HUMAN Protein PINCH (Particularly interesting new Cys-His protein)
(LIM and senescent cell antigen-like domains 1)
Length=325
Score = 56.6 bits (135), Expect = 2e-08
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 1/100 (1%)
Query 394 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 453
+L+H CFVC+ C + + +++ + YC + P C C E I +A N
Sbjct 29 ELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFII-GRVIKAMN 87
Query 454 QNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA 493
+WH + F C C +LA +V + +C+PC+ + A
Sbjct 88 NSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKA 127
Score = 55.8 bits (133), Expect = 4e-08
Identities = 38/142 (26%), Positives = 60/142 (42%), Gaps = 10/142 (7%)
Query 358 EDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYD--------KLWHPACFVCSTCHEL 409
++ +A+ + + YC K G P A R + K WH FVC+ C +
Sbjct 166 KELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKP 225
Query 410 LVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSI 469
+ ++ + YC HY C C+ +I + A N+ W + F C C++
Sbjct 226 FLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVI-EGDVVSALNKAWCVNCFACSTCNTK 284
Query 470 LA-GEIYVMVNDKPVCKPCYVK 490
L +V + KPVCK CY K
Sbjct 285 LTLKNKFVEFDMKPVCKKCYEK 306
Score = 34.3 bits (77), Expect = 0.13
Identities = 22/113 (19%), Positives = 37/113 (32%), Gaps = 26/113 (23%)
Query 401 FVCSTCHELLVDMIYFWKNE-------------------------KLYCGRHYCDSEKPR 435
++C CH ++ + +KN+ +LYC + P
Sbjct 133 YICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPI 192
Query 436 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
C C I A + WH++HF C C+ G + C+ Y
Sbjct 193 CGACRRPI-EGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHY 244
>gi|68565455|sp|Q5TD97|FHL5_HUMAN Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive
element modulator in testis) (Activator of CREM
in testis)
Length=284
Score = 56.2 bits (134), Expect = 3e-08
Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 1/102 (0%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF-SNEYTQA 451
D+ WH CF C+ C+ LV+ + K+E+L C Y + +C C I + +
Sbjct 59 DRHWHEGCFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEF 118
Query 452 ENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHA 493
+ WH F C +C + + + C PC+ K A
Sbjct 119 KGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFA 160
Score = 53.1 bits (126), Expect = 3e-07
Identities = 34/122 (27%), Positives = 49/122 (40%), Gaps = 7/122 (5%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCD 430
C+ CK ++ G + + WH CFVC C + + K YC +
Sbjct 102 CFHCKRTIMPGSRKMEFK----GNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCFEK 157
Query 431 SEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 490
C C ++I S T + Q WH + F C C L E ++ +D P C CY
Sbjct 158 EFAHYCNFCKKVITSGGITFCD-QLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCY-- 214
Query 491 NH 492
NH
Sbjct 215 NH 216
Score = 51.6 bits (122), Expect = 8e-07
Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELI---FSNEYT 449
D+LWH CF+CS C + L + + +++ +C Y +C C + I ++
Sbjct 179 DQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYNHLYANKCVACSKPISGLTGAKFI 238
Query 450 QAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPC 487
++ WH + F C C L G+ ++ N + C+ C
Sbjct 239 CFQDSQWHSECFNCGKCSVSLVGKGFLTQNKEIFCQKC 276
Score = 37.7 bits (86), Expect = 0.012
Identities = 23/91 (25%), Positives = 39/91 (42%), Gaps = 1/91 (1%)
Query 399 ACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA-ENQNWH 457
A F C C L+ Y K++ YC Y C C + I S+ ++++WH
Sbjct 4 AHFYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWH 63
Query 458 LKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
F C C+ L + + +++ +C CY
Sbjct 64 EGCFKCTKCNHSLVEKPFAAKDERLLCTECY 94
>gi|8134548|sp|Q9UPM6|LHX61_HUMAN LIM/homeobox protein Lhx6.1 (Lhx6)
Length=363
Score = 55.8 bits (133), Expect = 4e-08
Identities = 29/97 (29%), Positives = 49/97 (50%), Gaps = 3/97 (3%)
Query 395 LWHPACFVCSTCHELLVDM-IYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT-QAE 452
+WH C CS C L + KN++++C Y +CA C I+++++ +A
Sbjct 89 IWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRAR 148
Query 453 NQNWHLKHFCCFDCDSILA-GEIYVMVNDKPVCKPCY 488
+HL F CF C L+ GE + +V +K +C+ Y
Sbjct 149 GNAYHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHY 185
>gi|1708824|sp|P53671|LIMK2_HUMAN LIM domain kinase 2 (LIMK-2)
Length=638
Score = 55.1 bits (131), Expect = 7e-08
Identities = 30/98 (30%), Positives = 48/98 (48%), Gaps = 4/98 (4%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 452
++ WH +CF CS C + L + Y+ K+ KLYC + Y C GC L+ + + A
Sbjct 30 NETWHGSCFRCSECQDSLTNW-YYEKDGKLYCPKDYWGKFGEFCHGC-SLLMTGPFMVAG 87
Query 453 NQNWHLKHFCCFDCDSILA-GEIYVMVNDKPV-CKPCY 488
+H + F C C I+ G+ Y +V + C C+
Sbjct 88 EFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCH 125
Score = 29.6 bits (65), Expect = 3.3
Identities = 14/42 (33%), Positives = 19/42 (45%), Gaps = 1/42 (2%)
Query 435 RCAGC-DELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIY 475
RC GC D + S + + N+ WH F C +C L Y
Sbjct 11 RCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYY 52
>gi|60416412|sp|P48742|LHX1_HUMAN LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox
protein Lim-1)
Length=406
Score = 54.7 bits (130), Expect = 9e-08
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT-QA 451
D+ WH C C C L + F + KLYC + +CAGC + I ++ +A
Sbjct 21 DRAWHVKCVQCCECKCNLTEKC-FSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRA 79
Query 452 ENQNWHLKHFCCFDCDSILA--GEIYVMVNDKPVCKPCYVKN 491
++ +HL F C C+ L+ E+Y++ +K VCK Y+ N
Sbjct 80 RSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSN 121
>gi|2497677|sp|Q15942|ZYX_HUMAN Zyxin (Zyxin-2)
Length=572
Score = 53.1 bits (126), Expect = 3e-07
Identities = 67/289 (23%), Positives = 107/289 (37%), Gaps = 34/289 (11%)
Query 220 PMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAG--SEG 277
P + +V T PV+ T PP + A A ++ + PK PVA S G
Sbjct 232 PQVQLHVQSQTQPVSLAN-------TQPRGPPASSPAPAPKFSPVTPKFT-PVASKFSPG 283
Query 278 AQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQG 337
A Q H + S + + F + E V + + P AQ
Sbjct 284 APGGSGSQPNQKLGHPEALS-----AGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQN 338
Query 338 PKQMNIPGG------------DRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAI 385
Q+ PG ++ T + ME ++ C C + PA+
Sbjct 339 QNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAV 398
Query 386 YAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFS 445
A +L+H ACF C C + L ++ YC Y D+ + +C C E I +
Sbjct 399 RA----LGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLE-KCNTCGEPI-T 452
Query 446 NEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVN-DKPVCKPCYVKNHA 493
+ +A + +H F C C L G +++ ++P C P Y K +A
Sbjct 453 DRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYA 501
Score = 40.0 bits (92), Expect = 0.002
Identities = 37/150 (24%), Positives = 52/150 (34%), Gaps = 24/150 (16%)
Query 331 CEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERA 390
C QG + ++ G P G D T C C G+P
Sbjct 415 CAQQLQGQQFYSLEGA----PYCEGCYTD-------TLEKCNTC------GEPITDRMLR 457
Query 391 GYDKLWHPACFVCSTCHELLVDMIYFWKN-EKLYCGRHYCDSEKPRCAGCDELIFSNEYT 449
K +HP CF C C L + + +C Y PRC+ C E I
Sbjct 458 ATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGR 517
Query 450 Q------AENQNWHLKHFCCFDCDSILAGE 473
A ++N+H+K + C DC L+ E
Sbjct 518 DETVRVVALDKNFHMKCYKCEDCGKPLSIE 547
>gi|18202938|sp|Q9H2C1|LHX5_HUMAN LIM/homeobox protein Lhx5
Length=402
Score = 53.1 bits (126), Expect = 3e-07
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT-QA 451
D+ WH C C C L + F + KLYC + +CAGC + I ++ +A
Sbjct 22 DRAWHIKCVQCCECKTNLSEKC-FSREGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKA 80
Query 452 ENQNWHLKHFCCFDCDSILA--GEIYVMVNDKPVCKPCYVKN 491
++ +HL F C C+ L+ E+YV+ +K VCK Y+ +
Sbjct 81 RSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYLSS 122
Score = 28.9 bits (63), Expect = 5.5
Identities = 11/40 (27%), Positives = 20/40 (50%), Gaps = 0/40 (0%)
Query 436 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIY 475
CAGC+ I ++ WH+K C +C + L+ + +
Sbjct 5 CAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCF 44
>gi|56404448|sp|O94929|ABLM3_HUMAN Actin-binding LIM protein 3 (Actin-binding LIM protein family
member 3) (abLIM3)
Length=683
Score = 52.4 bits (124), Expect = 5e-07
Identities = 36/108 (33%), Positives = 48/108 (44%), Gaps = 17/108 (15%)
Query 394 KLWHPACFVCSTCHEL--LVDMIYFWKNEKLYCGRHYCD----SEKP-------RCAGCD 440
+ +HP CFVCS C + + D + F E C C S KP CAGC
Sbjct 99 RTYHPKCFVCSLCRKPFPIGDKVTFSGKE---CVCQTCSQSMASSKPIKIRGPSHCAGCK 155
Query 441 ELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
E I + A ++ WH+ F C C IL GE Y+ + P C+ Y
Sbjct 156 EEIKHGQSLLALDKQWHVSCFKCQTCSVILTGE-YISKDGVPYCESDY 202
Score = 48.1 bits (113), Expect = 9e-06
Identities = 34/119 (28%), Positives = 50/119 (42%), Gaps = 11/119 (9%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCD 430
C CK +K G + DK WH +CF C TC +L Y K+ YC Y
Sbjct 151 CAGCKEEIKHGQSLL-----ALDKQWHVSCFKCQTCSVILTGE-YISKDGVPYCESDYHA 204
Query 431 SEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSIL--AGEIYVMVND--KPVCK 485
+C CD I S +A +++H C C + E+Y+ ++ P+CK
Sbjct 205 QFGIKCETCDRYI-SGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICK 262
Score = 43.5 bits (101), Expect = 2e-04
Identities = 26/93 (27%), Positives = 39/93 (41%), Gaps = 2/93 (2%)
Query 396 WHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQN 455
+H CF C C L +F+KN++ C + Y RC C + I + E A +
Sbjct 42 FHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFI-TGEVISALGRT 100
Query 456 WHLKHFCCFDC-DSILAGEIYVMVNDKPVCKPC 487
+H K F C C G+ + VC+ C
Sbjct 101 YHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTC 133
>gi|12643415|sp|Q9UBR4|LHX3_HUMAN LIM/homeobox protein Lhx3
Length=397
Score = 52.4 bits (124), Expect = 5e-07
Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT-QA 451
D+ WH C CS CH L + F + E +YC + +CA C I + +A
Sbjct 48 DRHWHSKCLKCSDCHTPLAERC-FSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRA 106
Query 452 ENQNWHLKHFCCFDCDSILA--GEIYVMVNDKPVCKPCY 488
++ +HL F C C LA E Y+M + + VCK Y
Sbjct 107 QDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADY 145
Score = 38.5 bits (88), Expect = 0.007
Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query 432 EKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 490
E P CAGCD+ I +A +++WH K C DC + LA + + CK + K
Sbjct 27 EIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSR-GESVYCKDDFFK 84
Score = 33.5 bits (75), Expect = 0.23
Identities = 20/66 (30%), Positives = 26/66 (39%), Gaps = 6/66 (9%)
Query 365 KRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLV--DMIYFWKNEKL 422
KR C C+L G P R D ++H CF C C L D Y ++ +L
Sbjct 84 KRFGTKCAACQL----GIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRL 139
Query 423 YCGRHY 428
C Y
Sbjct 140 VCKADY 145
>gi|47605932|sp|Q9UGP4|LIMD1_HUMAN LIM domains-containing protein 1
Length=676
Score = 51.6 bits (122), Expect = 8e-07
Identities = 38/161 (23%), Positives = 65/161 (40%), Gaps = 8/161 (4%)
Query 327 VKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIY 386
V+LPC+ GP ++ + A +E + H + Y C K S
Sbjct 427 VRLPCQPLVPGP-ELRPSAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGAGQA 485
Query 387 AERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDS----EKPRCAGCDEL 442
+ G L+H CF C+ C L +++ N K++C + S RC C L
Sbjct 486 CQAMG--NLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHL 543
Query 443 IFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPV 483
I + QA +++H F C C+ L G + + ++ +
Sbjct 544 IM-DMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKI 583
Score = 48.5 bits (114), Expect = 7e-06
Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 10/107 (9%)
Query 394 KLWHPACFVCSTCHELLVDMIYFWKNE-KLYCGRHYCDSEKPRCAGCDELIFSNEYTQ-- 450
K +HP CF C C+E L + + +E K+YC R Y P+CA C I E +
Sbjct 554 KSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDET 613
Query 451 ----AENQNWHLKHFCCFDCDSIL---AGEIYVMVNDKPVCKPCYVK 490
+ ++++H++ + C DC L G + D C C+VK
Sbjct 614 IRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVK 660
>gi|3915762|sp|P53667|LIMK1_HUMAN LIM domain kinase 1 (LIMK-1)
Length=647
Score = 51.6 bits (122), Expect = 8e-07
Identities = 36/133 (27%), Positives = 53/133 (39%), Gaps = 8/133 (6%)
Query 358 EDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFW 417
E++ E C C + +G Y + D WH CF C C L Y+
Sbjct 12 EERMGEEGSELPVCASCGQRIYDGQ---YLQALNAD--WHADCFRCCDCSASLSHQ-YYE 65
Query 418 KNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILA-GEIYV 476
K+ +L+C + Y C GC E I A +H + F C C + + G+ Y
Sbjct 66 KDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYT 125
Query 477 MV-NDKPVCKPCY 488
+V + K C CY
Sbjct 126 LVEHSKLYCGHCY 138
Score = 46.6 bits (109), Expect = 3e-05
Identities = 22/59 (37%), Positives = 32/59 (54%), Gaps = 4/59 (6%)
Query 417 WKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIY 475
W+ E++ G SE P CA C + I+ +Y QA N +WH F C DC + L+ + Y
Sbjct 10 WREERM--GEE--GSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYY 64
>gi|47606423|sp|P61371|ISL1_HUMAN Insulin gene enhancer protein ISL-1 (Islet-1)
Length=349
Score = 49.3 bits (116), Expect = 4e-06
Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query 386 YAERAGYDKLWHPACFVCSTCHELLVD-MIYFWKNEKLYCGRHYCDSEKPRCAGCDELIF 444
Y R D WH AC C+ C++ L + F ++ K YC R Y +CA C
Sbjct 28 YILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFS 87
Query 445 SNEYT-QAENQNWHLKHFCCFDCD-SILAGEIYVMVNDKPVCK 485
N++ +A ++ +H++ F C C ++ G+ + + D C+
Sbjct 88 KNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCR 130
>gi|56404432|sp|O14639|ABLM1_HUMAN Actin-binding LIM protein 1 (Actin-binding LIM protein family
member 1) (abLIM-1) (Actin-binding double-zinc-finger protein)
(LIMAB1) (Limatin)
Length=778
Score = 49.3 bits (116), Expect = 4e-06
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 10/104 (9%)
Query 394 KLWHPACFVCSTCHELLV--DMIYFWKNEKL--YCGRHYCDSEKP-----RCAGCDELIF 444
K +HP CF C+ C D + F + L C + S K CAGC I
Sbjct 175 KTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIK 234
Query 445 SNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
+ + A ++ WHL F C C +L GE Y+ + P C+ Y
Sbjct 235 NGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPYCEKDY 277
Score = 45.4 bits (106), Expect = 6e-05
Identities = 34/133 (25%), Positives = 56/133 (42%), Gaps = 14/133 (10%)
Query 344 PGGDRSTPAAVGAM-----EDKSAEHKRTQYSCYC--CKLSMKEGDPAIYAERAGYDKLW 396
P GDR T + + S+ K T +S C C +K G + DK W
Sbjct 192 PPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQALL-----ALDKQW 246
Query 397 HPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNW 456
H CF C +C ++L Y K+ YC + Y +C C + I + + +A ++++
Sbjct 247 HLGCFKCKSCGKVLTGE-YISKDGAPYCEKDYQGLFGVKCEACHQFI-TGKVLEAGDKHY 304
Query 457 HLKHFCCFDCDSI 469
H C C+ +
Sbjct 305 HPSCARCSRCNQM 317
Score = 39.7 bits (91), Expect = 0.003
Identities = 23/73 (31%), Positives = 29/73 (39%), Gaps = 1/73 (1%)
Query 394 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAEN 453
K +H CF C C L +F KN + C Y RC GC E + E A
Sbjct 116 KHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFV-EGEVVTALG 174
Query 454 QNWHLKHFCCFDC 466
+ +H F C C
Sbjct 175 KTYHPNCFACTIC 187
>gi|56404514|sp|Q6H8Q1|ABLM2_HUMAN Actin-binding LIM protein 2 (Actin-binding LIM protein family
member 2) (abLIM2)
Length=611
Score = 48.5 bits (114), Expect = 7e-06
Identities = 39/141 (27%), Positives = 60/141 (42%), Gaps = 15/141 (10%)
Query 349 STPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHE 408
S P +VG+ SA + SC C +K G + DK WH CF C +C +
Sbjct 135 SLPVSVGS----SAHLSQGLRSCGGCGTEIKNGQALV-----ALDKHWHLGCFKCKSCGK 185
Query 409 LLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDS 468
LL + Y K+ YC Y RC C++ I + +A +++H C C
Sbjct 186 LL-NAEYISKDGLPYCEADYHAKFGIRCDSCEKYI-TGRVLEAGEKHYHPSCALCVRCGQ 243
Query 469 ILA--GEIYVMVND--KPVCK 485
+ A E+Y+ + P C+
Sbjct 244 MFAEGEEMYLQGSSIWHPACR 264
Score = 41.2 bits (95), Expect = 0.001
Identities = 28/112 (25%), Positives = 44/112 (39%), Gaps = 24/112 (21%)
Query 394 KLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEK-----------------PRC 436
K +HP CFVC+ C + F +++ C +K C
Sbjct 100 KTYHPDCFVCAVCR------LPFPPGDRVTFNGKECMCQKCSLPVSVGSSAHLSQGLRSC 153
Query 437 AGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
GC I + + A +++WHL F C C +L E Y+ + P C+ Y
Sbjct 154 GGCGTEIKNGQALVALDKHWHLGCFKCKSCGKLLNAE-YISKDGLPYCEADY 204
Score = 40.8 bits (94), Expect = 0.001
Identities = 28/96 (29%), Positives = 38/96 (39%), Gaps = 2/96 (2%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 452
DK +H CFVC C L + +F + + C Y RC CD+ I E A
Sbjct 40 DKYFHIKCFVCKACGCDLAEGGFFVRQGEYICTLDYQRLYGTRCFSCDQFI-EGEVVSAL 98
Query 453 NQNWHLKHFCCFDCDSILAGEIYVMVNDKP-VCKPC 487
+ +H F C C V N K +C+ C
Sbjct 99 GKTYHPDCFVCAVCRLPFPPGDRVTFNGKECMCQKC 134
>gi|38257688|sp|Q8WUP2|FBLI1_HUMAN Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1)
(FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting
protein) (Migfilin)
Length=373
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 10/108 (9%)
Query 396 WHPACFVCSTCHELLVDMIY-FWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQA--- 451
+HP+CF C TC + D + ++YC + P C+ C+ I + A
Sbjct 262 FHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKI 321
Query 452 --ENQNWHLKHFCCFDCDSILAGEIYVM----VNDKPVCKPCYVKNHA 493
+N+H + C DC +L+ E +N+ CKPC+VK A
Sbjct 322 ECMGRNFHENCYRCEDCRILLSVEPTDQGCYPLNNHLFCKPCHVKRSA 369
Score = 45.1 bits (105), Expect = 7e-05
Identities = 36/154 (23%), Positives = 61/154 (39%), Gaps = 8/154 (5%)
Query 330 PCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAER 389
P + A+GP PG R + + E + C C ++ + A+ A +
Sbjct 144 PPQAPAEGPSVQ--PGPLRPMEEELPPPPAEPVEKGASTDICAFCHKTVFPRELAVEAMK 201
Query 390 AGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT 449
Y H CF C TC L ++ K+ + C Y D+ + RC C E++ +
Sbjct 202 RQY----HAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLE-RCGKCGEVV-RDHII 255
Query 450 QAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPV 483
+A Q +H F C C + E + + + V
Sbjct 256 RALGQAFHPSCFTCVTCARCIGDESFALGSQNEV 289
Score = 43.1 bits (100), Expect = 3e-04
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query 436 CAGCDELIFSNEYT-QAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCY 488
CA C + +F E +A + +H + F C C LAG+ + + +P+C+PCY
Sbjct 183 CAFCHKTVFPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCY 236
>gi|20978495|sp|Q96A47|ISL2_HUMAN Insulin gene enhancer protein ISL-2 (Islet-2)
Length=359
Score = 45.1 bits (105), Expect = 7e-05
Identities = 35/135 (25%), Positives = 60/135 (44%), Gaps = 8/135 (5%)
Query 354 VGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVD- 412
+GAM D S + T C C + + + R D WH AC C+ C + L +
Sbjct 11 LGAMGDHSKKKPGTAM-CVGCGSQIHDQ----FILRVSPDLEWHAACLKCAECSQYLDET 65
Query 413 MIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYT-QAENQNWHLKHFCCFDCD-SIL 470
F ++ K YC R Y +CA C S++ +A + +H++ F C C +L
Sbjct 66 CTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLL 125
Query 471 AGEIYVMVNDKPVCK 485
G+ + + + +C+
Sbjct 126 PGDEFSLREHELLCR 140
>gi|20141642|sp|P50479|PDLI4_HUMAN PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced
LIM protein)
Length=330
Score = 44.7 bits (104), Expect = 1e-04
Identities = 20/42 (47%), Positives = 25/42 (59%), Gaps = 0/42 (0%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKP 434
DKL+HP CF+CS C L YF+ +E+LYC H KP
Sbjct 271 DKLYHPECFMCSDCGLNLKQRGYFFLDERLYCESHAKARVKP 312
>gi|48428992|sp|P61968|LMO4_HUMAN LIM domain transcription factor LMO4 (LIM domain only protein
4) (LMO-4) (Breast tumor autoantigen)
Length=165
Score = 42.0 bits (97), Expect = 6e-04
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 6/99 (6%)
Query 393 DKLWHPACFVCSTCHELLVDM--IYFWKNEKLYCGRHYCD--SEKPRCAGCDELIFSNEY 448
D WH C CS C L D+ + K+ + C Y C+ C + I ++E
Sbjct 40 DSYWHSRCLKCSCCQAQLGDIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASEL 99
Query 449 T-QAENQNWHLKHFCCFDC-DSILAGEIYVMVNDKPVCK 485
+A+ +HLK F C C + ++ G+ + +N C+
Sbjct 100 VMRAQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCE 138
>gi|74740479|sp|Q53GG5|PDLI3_HUMAN PDZ and LIM domain protein 3 (Actinin-associated LIM protein)
(Alpha-actinin-2-associated LIM protein)
Length=364
Score = 41.6 bits (96), Expect = 8e-04
Identities = 29/91 (31%), Positives = 36/91 (39%), Gaps = 7/91 (7%)
Query 344 PGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVC 403
P G RS A V + S +R C G + A DK HP CFVC
Sbjct 268 PAGTRSVRAPVTKVHGGSGGAQRMPLCDKC-------GSGIVGAVVKARDKYRHPECFVC 320
Query 404 STCHELLVDMIYFWKNEKLYCGRHYCDSEKP 434
+ C+ L YF+ +LYC H KP
Sbjct 321 ADCNLNLKQKGYFFIEGELYCETHARARTKP 351
>gi|20981729|sp|Q15654|TRIP6_HUMAN Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting
protein 1) (Zyxin-related protein 1) (ZRP-1)
Length=476
Score = 41.2 bits (95), Expect = 0.001
Identities = 24/80 (30%), Positives = 37/80 (46%), Gaps = 2/80 (2%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 452
D+++H CFVCSTC L ++ + YC Y + +CA C + I + +A
Sbjct 297 DRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYV-ATLEKCATCSQPIL-DRILRAM 354
Query 453 NQNWHLKHFCCFDCDSILAG 472
+ +H F C C L G
Sbjct 355 GKAYHPGCFTCVVCHRGLDG 374
Score = 32.3 bits (72), Expect = 0.50
Identities = 16/56 (28%), Positives = 28/56 (50%), Gaps = 1/56 (1%)
Query 435 RCAGCDE-LIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYV 489
+C GC E ++ A ++ +H+ F C C + L G+ + V + C+ CYV
Sbjct 278 QCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYV 333
>gi|3122342|sp|Q14847|LASP1_HUMAN LIM and SH3 domain protein 1 (LASP-1) (MLN 50)
Length=261
Score = 40.4 bits (93), Expect = 0.002
Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 0/69 (0%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 452
DK WH ACF C TC L Y +K YC HY A E + + ++ +
Sbjct 22 DKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQ 81
Query 453 NQNWHLKHF 461
+Q + + F
Sbjct 82 SQVRYKEEF 90
Score = 36.6 bits (83), Expect = 0.027
Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 0/57 (0%)
Query 434 PRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVK 490
P CA C ++++ E ++ WH F C C L + Y KP C Y K
Sbjct 3 PNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPK 59
>gi|74751663|sp|Q93052|LPP_HUMAN Lipoma-preferred partner (LIM domain-containing preferred translocation
partner in lipoma)
Length=612
Score = 40.4 bits (93), Expect = 0.002
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 1/56 (1%)
Query 435 RCAGCDE-LIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYV 489
RCA C E ++ A +Q +H+ F C C++ L G+ + V K C+PCY+
Sbjct 415 RCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYI 470
Score = 35.0 bits (79), Expect = 0.077
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 2/80 (2%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAE 452
D+++H CF C C+ L ++ +K YC Y ++ + +C C + I +A
Sbjct 434 DQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLE-QCNVCSKPIM-ERILRAT 491
Query 453 NQNWHLKHFCCFDCDSILAG 472
+ +H F C C L G
Sbjct 492 GKAYHPHCFTCVMCHRSLDG 511
>gi|12643346|sp|Q9NQ69|LHX9_HUMAN LIM/homeobox protein Lhx9
Length=388
Score = 38.1 bits (87), Expect = 0.009
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query 432 EKPR-CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPV-CKPCYV 489
EKP CAGC I Y A ++ WHL+ C +C L E+ D + CK Y
Sbjct 57 EKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYY 116
Query 490 K 490
+
Sbjct 117 R 117
Score = 36.6 bits (83), Expect = 0.027
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYF-WKNEKLYCGRHY 428
C C L + + + A D ++H +CF CSTC++ L +F K+ +YC H+
Sbjct 124 CARCHLGISASEMVMRAR----DSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHF 178
>gi|118161|sp|P21291|CSRP1_HUMAN Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1)
(CRP1) (CRP)
Length=193
Score = 37.0 bits (84), Expect = 0.020
Identities = 16/57 (28%), Positives = 24/57 (42%), Gaps = 0/57 (0%)
Query 435 RCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKN 491
RC C + +++ E ++WH F C C L + + CK CY KN
Sbjct 118 RCPRCSQAVYAAEKVIGAGKSWHKACFRCAKCGKGLESTTLADKDGEIYCKGCYAKN 174
Score = 36.2 bits (82), Expect = 0.035
Identities = 15/58 (25%), Positives = 25/58 (43%), Gaps = 0/58 (0%)
Query 435 RCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNH 492
+C C + ++ E Q E ++H F C C L + ++ CK CY K +
Sbjct 9 KCGVCQKTVYFAEEVQCEGNSFHKSCFLCMVCKKNLDSTTVAVHGEEIYCKSCYGKKY 66
Score = 35.4 bits (80), Expect = 0.059
Identities = 34/133 (25%), Positives = 54/133 (40%), Gaps = 24/133 (18%)
Query 315 KKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRT---QYSC 371
KKY + G G QG ++ G+ ++G +++ H+ T S
Sbjct 64 KKYGPKGYGYG----------QGAGTLSTDKGE-----SLGIKHEEAPGHRPTTNPNASK 108
Query 372 YCCKLSMKEGDP----AIYAERA--GYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 425
+ K+ E P A+YA G K WH ACF C+ C + L K+ ++YC
Sbjct 109 FAQKIGGSERCPRCSQAVYAAEKVIGAGKSWHKACFRCAKCGKGLESTTLADKDGEIYCK 168
Query 426 RHYCDSEKPRCAG 438
Y + P+ G
Sbjct 169 GCYAKNFGPKGFG 181
>gi|67461069|sp|Q96JY6|PDLI2_HUMAN PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM
protein)
Length=352
Score = 36.6 bits (83), Expect = 0.027
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 3/55 (5%)
Query 373 CCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 427
C K S + A+ + Y HP C+ C+ C L +FW ++LYC +H
Sbjct 286 CEKCSTSIANQAVRIQEGRYR---HPGCYTCADCGLNLKMRGHFWVGDELYCEKH 337
>gi|2497674|sp|Q16527|CSRP2_HUMAN Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2)
(CRP2) (Smooth muscle cell LIM protein) (SmLIM) (LIM-only protein
5)
Length=193
Score = 35.4 bits (80), Expect = 0.059
Identities = 15/57 (26%), Positives = 23/57 (40%), Gaps = 0/57 (0%)
Query 435 RCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKN 491
+C+ C + +++ E + WH F C C L + CK CY KN
Sbjct 118 KCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCKGCYAKN 174
Score = 35.0 bits (79), Expect = 0.077
Identities = 14/58 (24%), Positives = 26/58 (44%), Gaps = 0/58 (0%)
Query 435 RCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNH 492
+C C ++ E Q + +++H F C C L + +++ CK CY K +
Sbjct 9 KCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNLDSTTVAIHDEEIYCKSCYGKKY 66
Score = 34.7 bits (78), Expect = 0.10
Identities = 35/133 (26%), Positives = 50/133 (37%), Gaps = 24/133 (18%)
Query 315 KKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRT---QYSC 371
KKY + G G QG +N+ G+R +G + H+ T S
Sbjct 64 KKYGPKGYGYG----------QGAGTLNMDRGER-----LGIKPESVQPHRPTTNPNTSK 108
Query 372 YCCKLSMKE-----GDPAIYAERA-GYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCG 425
+ K E GD AE+ G K WH CF C+ C + L K ++YC
Sbjct 109 FAQKYGGAEKCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCK 168
Query 426 RHYCDSEKPRCAG 438
Y + P+ G
Sbjct 169 GCYAKNFGPKGFG 181
>gi|33302611|sp|P12036|NFH_HUMAN Neurofilament triplet H protein (200 kDa neurofilament protein)
(Neurofilament heavy polypeptide) (NF-H)
Length=1026
Score = 35.0 bits (79), Expect = 0.077
Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 5/105 (4%)
Query 266 PKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVG 325
P ++ + + A+ K+ AK PA + P K SP EVK E+ K EA
Sbjct 504 PPAEEAASPEKEAKSPVKEEAKS-PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPP 562
Query 326 DVKLPCEMDAQGPKQMNIPGGDRSTPA---AVGAMEDKSAEHKRT 367
+ K P + +A+ P ++ P +S PA A E KS E ++
Sbjct 563 EAKSPEKEEAKSPAEVKSPEKAKS-PAKEEAKSPAEAKSPEKAKS 606
Score = 33.1 bits (74), Expect = 0.29
Identities = 20/74 (27%), Positives = 31/74 (41%), Gaps = 0/74 (0%)
Query 271 PVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLP 330
P A S + K + P + P+K SP E K E+ K EA + K P
Sbjct 562 PEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP 621
Query 331 CEMDAQGPKQMNIP 344
+ +A+ P ++ P
Sbjct 622 VKEEAKSPAEVKSP 635
Score = 29.6 bits (65), Expect = 3.3
Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 1/92 (1%)
Query 253 QNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQ 312
++ A A+ ++ K V E A+ K+ AK P + P K E K E+
Sbjct 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS-PEKAKSPEKAKSPEKEEAKSPEK 671
Query 313 FVKKYKSEALGVGDVKLPCEMDAQGPKQMNIP 344
K+EA K P + +A+ P++ P
Sbjct 672 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 703
Score = 28.5 bits (62), Expect = 7.2
Identities = 24/103 (23%), Positives = 39/103 (37%), Gaps = 9/103 (8%)
Query 251 PVQNQALARQYMQMLPKEKQPV---------AGSEGAQYRKKQLAKQLPAHDQDPSKCHE 301
P + +A + + K K PV A S + K + P + P+K
Sbjct 587 PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEA 646
Query 302 LSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIP 344
SP + K E+ K EA K P + +A+ P++ P
Sbjct 647 KSPEKAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 689
Score = 28.1 bits (61), Expect = 9.5
Identities = 23/100 (23%), Positives = 40/100 (40%), Gaps = 1/100 (1%)
Query 267 KEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGD 326
+E++ G E + + A + P K SP E K E+ K +E
Sbjct 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query 327 VKLPCEMDAQGPKQMNIPGGDRS-TPAAVGAMEDKSAEHK 365
K P + +A+ P + P + + +PA V + E + K
Sbjct 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAK 589
>gi|46396312|sp|Q7RTP6|MICA3_HUMAN Protein MICAL-3
Length=976
Score = 35.0 bits (79), Expect = 0.077
Identities = 24/92 (26%), Positives = 38/92 (41%), Gaps = 10/92 (10%)
Query 343 IPGGDRSTPAA---VGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPA 399
+PG R P G+M+ + ++ +CY C+ + + + K +H +
Sbjct 761 LPGQVRPAPTPRWKQGSMKKEFPQNLGGSDTCYFCQKRVY-----VMERLSAEGKFFHRS 815
Query 400 CFVCSTCHELLVDMIYFWKNE--KLYCGRHYC 429
CF C C L Y + E K YC HYC
Sbjct 816 CFKCEYCATTLRLSAYAYDIEDGKFYCKPHYC 847
>gi|1705933|sp|P50461|CSRP3_HUMAN Cysteine and glycine-rich protein 3 (Cysteine-rich protein 3)
(CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)
Length=194
Score = 35.0 bits (79), Expect = 0.077
Identities = 16/60 (26%), Positives = 24/60 (40%), Gaps = 0/60 (0%)
Query 432 EKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKN 491
E +C C + +++ E + WH F C C L + + CK CY KN
Sbjct 116 ESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKN 175
Score = 33.1 bits (74), Expect = 0.29
Identities = 13/58 (22%), Positives = 24/58 (41%), Gaps = 0/58 (0%)
Query 435 RCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNH 492
+C C++ ++ E Q +++H F C C L + CK CY + +
Sbjct 9 KCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRY 66
Score = 30.8 bits (68), Expect = 1.5
Identities = 24/90 (26%), Positives = 33/90 (36%), Gaps = 12/90 (13%)
Query 349 STPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHE 408
S P+ A +S + R S Y + M G P WH CF C+ C +
Sbjct 105 SNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKP------------WHKTCFRCAICGK 152
Query 409 LLVDMIYFWKNEKLYCGRHYCDSEKPRCAG 438
L K+ +LYC Y + P G
Sbjct 153 SLESTNVTDKDGELYCKVCYAKNFGPTGIG 182
>gi|20178312|sp|O00151|PDLI1_HUMAN PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36)
(C-terminal LIM domain protein 1)
Length=329
Score = 34.3 bits (77), Expect = 0.13
Identities = 12/35 (34%), Positives = 21/35 (60%), Gaps = 0/35 (0%)
Query 393 DKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRH 427
D+ HP C+VC+ C L +F+ +++YC +H
Sbjct 276 DRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKH 310
>gi|8247936|sp|P50458|LHX2_HUMAN LIM/homeobox protein Lhx2 (Homeobox protein LH-2)
Length=406
Score = 34.3 bits (77), Expect = 0.13
Identities = 17/56 (30%), Positives = 25/56 (44%), Gaps = 1/56 (1%)
Query 436 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPV-CKPCYVK 490
CAGC I Y A ++ WH++ C +C L E+ D + CK Y +
Sbjct 53 CAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYR 108
Score = 34.3 bits (77), Expect = 0.13
Identities = 17/59 (28%), Positives = 30/59 (50%), Gaps = 5/59 (8%)
Query 371 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYF-WKNEKLYCGRHY 428
C C L + + + A D ++H CF C+TC+++L +F K+ +YC H+
Sbjct 115 CARCHLGISASEMVMRAR----DLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHF 169
>gi|1706133|sp|P52943|CRIP2_HUMAN Cysteine-rich protein 2 (CRP2) (Protein ESP1)
Length=208
Score = 34.3 bits (77), Expect = 0.13
Identities = 16/55 (29%), Positives = 25/55 (45%), Gaps = 1/55 (1%)
Query 435 RCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVC-KPCY 488
+C CD+ ++ E + ++WH C C L + + KP C KPCY
Sbjct 4 KCPKCDKTVYFAEKVSSLGKDWHKFCLKCERCSKTLTPGGHAEHDGKPFCHKPCY 58
Score = 29.6 bits (65), Expect = 3.3
Identities = 15/58 (25%), Positives = 24/58 (41%), Gaps = 1/58 (1%)
Query 432 EKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVC-KPCY 488
E C C + ++ E + ++WH C C L + + +P C KPCY
Sbjct 122 EPNTCPRCSKKVYFAEKVTSLGKDWHRPCLRCERCGKTLTPGGHAEHDGQPYCHKPCY 179
>gi|55976743|sp|Q8N8J6|ZN615_HUMAN Zinc finger protein 615
Length=555
Score = 33.9 bits (76), Expect = 0.17
Identities = 22/83 (26%), Positives = 41/83 (49%), Gaps = 10/83 (12%)
Query 402 VCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPR-CAGCDELIFSNEYTQAENQNWH--L 458
VCS C + + + F +++++ G EKP C+ C + FS + ++Q H L
Sbjct 29 VCSECGKAFLKLSQFIDHQRVHTG------EKPHVCSMCGKA-FSRKSRLMDHQRTHTEL 81
Query 459 KHFCCFDCDSILAGEIYVMVNDK 481
KH+ C +CD + + ++ K
Sbjct 82 KHYECTECDKTFLKKSQLNIHQK 104
>gi|20138668|sp|Q969G2|LHX4_HUMAN LIM/homeobox protein Lhx4
Length=367
Score = 33.5 bits (75), Expect = 0.23
Identities = 21/76 (27%), Positives = 31/76 (40%), Gaps = 6/76 (7%)
Query 355 GAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLV--D 412
G++ K KR C C+ +G P R D ++H CF C C+ L D
Sbjct 50 GSVYCKEDFFKRFGTKCTACQ----QGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGD 105
Query 413 MIYFWKNEKLYCGRHY 428
Y ++ +L C Y
Sbjct 106 EFYLMEDGRLVCKEDY 121
Score = 33.1 bits (74), Expect = 0.29
Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 0/42 (0%)
Query 434 PRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIY 475
P+CAGC++ I + +++WH C DC LA +
Sbjct 5 PQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCF 46
>gi|20981688|sp|P50238|CRIP1_HUMAN Cysteine-rich protein 1 (Cysteine-rich intestinal protein) (CRIP)
(Cysteine-rich heart protein) (hCRHP)
Length=77
Score = 33.1 bits (74), Expect = 0.29
Identities = 15/56 (26%), Positives = 24/56 (42%), Gaps = 1/56 (1%)
Query 434 PRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCK-PCY 488
P+C C++ ++ E + ++WH C C L + KP C PCY
Sbjct 2 PKCPKCNKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCY 57
>gi|13124093|sp|Q9UBU2|DKK2_HUMAN Dickkopf-related protein 2 precursor (Dkk-2) (Dickkopf-2) (hDkk-2)
Length=259
Score = 32.7 bits (73), Expect = 0.38
Identities = 16/32 (50%), Positives = 19/32 (59%), Gaps = 5/32 (15%)
Query 148 GHEQGFGAPCLKCKEKCEGF--ELHFWRKICR 177
GHE G PCL+ + EGF HFW KIC+
Sbjct 177 GHE---GDPCLRSSDCIEGFCCARHFWTKICK 205
>gi|20138067|sp|Q9UHB6|EPLIN_HUMAN Epithelial protein lost in neoplasm
Length=759
Score = 32.3 bits (72), Expect = 0.50
Identities = 14/51 (27%), Positives = 25/51 (49%), Gaps = 0/51 (0%)
Query 436 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKP 486
C C + ++ E A Q +H+ F C C++ L+ Y ++ + CKP
Sbjct 390 CVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKP 440
>gi|13123967|sp|Q9Y2D5|AKAP2_HUMAN A-kinase anchor protein 2 (Protein kinase A-anchoring protein
2) (PRKA2) (AKAP-2)
Length=1103
Score = 32.0 bits (71), Expect = 0.65
Identities = 35/134 (26%), Positives = 55/134 (41%), Gaps = 11/134 (8%)
Query 194 EDRKVGKLFEDTKYTT---LIAKLK-SDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWA 249
ED+K KLFED ++ I K++ S+ + ++ L A KKN I W
Sbjct 417 EDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGI--AAKWWN 474
Query 250 PPVQ---NQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPRE 306
PP + + L ++++ K K+ AQ + L KQL Q P +P
Sbjct 475 PPQEKTIEEQLDEEHLESHKKYKE--RKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPAS 532
Query 307 VKEMEQFVKKYKSE 320
E + K K +
Sbjct 533 SHERASMIDKAKED 546
>gi|51338794|sp|P78559|MAP1A_HUMAN Microtubule-associated protein 1A (MAP 1A) (Proliferation-related
protein p80) [Contains: MAP1 light chain LC2]
Length=2805
Score = 31.6 bits (70), Expect = 0.86
Identities = 29/113 (25%), Positives = 54/113 (47%), Gaps = 8/113 (7%)
Query 224 RNVMILTNPVAAKKNVSINTVTYEWAPP-VQNQALARQYMQMLPKE------KQPVAGSE 276
R++ L PVA +K+++ V P ++ +A +++ ++ K K+ E
Sbjct 284 RHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKLAKREEVVEE 343
Query 277 GAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKL 329
GA+ + +LAK+L ++ + E P + + E+ VK SEAL KL
Sbjct 344 GAKEARSELAKELAKTEKKAKESSEKPPEKPAKPER-VKTESSEALKAEKRKL 395
>gi|20140876|sp|Q9NYK1|TLR7_HUMAN Toll-like receptor 7 precursor
Length=1049
Score = 30.0 bits (66), Expect = 2.5
Identities = 22/82 (26%), Positives = 35/82 (42%), Gaps = 11/82 (13%)
Query 140 NKVKKMGLGHEQGFGAPCLKCKEKCEGFE------LHFWR--KICRNCKCGQEEHDVLLS 191
NK+ G E GF C + E +E LH++R K R+C+ +E +
Sbjct 431 NKISPSGDSSEVGF---CSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSV 487
Query 192 NEEDRKVGKLFEDTKYTTLIAK 213
NE K G+ + +K + K
Sbjct 488 NESCYKYGQTLDLSKNSIFFVK 509
>gi|1170654|sp|P46013|KI67_HUMAN Antigen KI-67
Length=3256
Score = 30.0 bits (66), Expect = 2.5
Identities = 19/74 (25%), Positives = 39/74 (52%), Gaps = 10/74 (13%)
Query 269 KQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPRE----VKEMEQFVK-----KYKS 319
K+P +G EG + K++ K+ +++PS+ +P+E ++++ F + +
Sbjct 2634 KEPASGDEGIKVLKQRAKKKPNPVEEEPSRRRPRAPKEKAQPLEDLAGFTELSETSGHTQ 2693
Query 320 EALGVGD-VKLPCE 332
E+L G K+PCE
Sbjct 2694 ESLTAGKATKIPCE 2707
>gi|83308990|sp|Q7Z3V5|ZN571_HUMAN Zinc finger protein 571
Length=609
Score = 29.6 bits (65), Expect = 3.3
Identities = 22/95 (23%), Positives = 41/95 (43%), Gaps = 14/95 (14%)
Query 401 FVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDE-LIFSNEYTQAENQNWHLK 459
F C C + + + Y ++EK++ +HY C C + + + + T + + K
Sbjct 447 FECKECGKAFIRVAYLTQHEKIHGEKHY------ECKECGKTFVRATQLTYHQRIHTGEK 500
Query 460 HFCCFDCD------SILAGEIYVMVNDKPV-CKPC 487
+ C +CD S L+ + +KP CK C
Sbjct 501 PYKCKECDKAFIYGSQLSEHQRIHRGEKPYECKQC 535
>gi|20532312|sp|Q96GC6|ZN274_HUMAN Zinc finger protein 274 (Zinc finger protein HFB101) (Zinc finger
protein zfp2) (Zf2)
Length=653
Score = 29.3 bits (64), Expect = 4.2
Identities = 30/116 (25%), Positives = 47/116 (40%), Gaps = 3/116 (2%)
Query 226 VMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEG-AQYRKKQ 284
V+ L VA +N I + Y + A + Q Q P A + Q+R K
Sbjct 113 VLTLNQEVAGPRNAQIQAL-YAEDGSLSADAPSEQIQQQGKHPGDPEAARQRFRQFRYKD 171
Query 285 LAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEA-LGVGDVKLPCEMDAQGPK 339
+ A DQ CH+ + + EQ ++ E LG VKL +++Q P+
Sbjct 172 MTGPREALDQLRELCHQWLQPKARSKEQILELLVLEQFLGALPVKLRTWVESQHPE 227
>gi|61212124|sp|Q9H2A9|CHST8_HUMAN Carbohydrate sulfotransferase 8 (N-acetylgalactosamine-4-O-sulfotransferase
1) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1)
(GalNAc4ST-1)
Length=424
Score = 29.3 bits (64), Expect = 4.2
Identities = 13/51 (25%), Positives = 27/51 (52%), Gaps = 0/51 (0%)
Query 196 RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTY 246
R V ++F + ++ L ++ G +KR +M+L ++ ++ NTV Y
Sbjct 179 RHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHY 229
>gi|123402|sp|P09086|PO2F2_HUMAN POU domain, class 2, transcription factor 2 (Octamer-binding
transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted
immunoglobulin octamer binding protein NF-A2)
Length=479
Score = 28.9 bits (63), Expect = 5.5
Identities = 22/80 (27%), Positives = 32/80 (40%), Gaps = 6/80 (7%)
Query 251 PVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKC-----HELSPR 305
P N Q Q QP AG + L +H Q P KC H P
Sbjct 140 PTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLSHPQPP-KCLEPPSHPEEPS 198
Query 306 EVKEMEQFVKKYKSEALGVG 325
+++E+EQF + +K + +G
Sbjct 199 DLEELEQFARTFKQRRIKLG 218
>gi|34098603|sp|Q8TAP4|LMO3_HUMAN LIM-only protein 3 (Neuronal-specific transcription factor DAT1)
(Rhombotin-3)
Length=145
Score = 28.9 bits (63), Expect = 5.5
Identities = 14/47 (29%), Positives = 20/47 (42%), Gaps = 1/47 (2%)
Query 383 PAIYAERAGYDKLWHPACFVCSTCHE-LLVDMIYFWKNEKLYCGRHY 428
PA D ++H CF C C++ V +F KN + C Y
Sbjct 85 PAFEMVMRAKDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDY 131
>gi|132532|sp|P25800|RBTN1_HUMAN Rhombotin-1 (Cysteine-rich protein TTG-1) (T-cell translocation
protein 1) (LIM-only protein 1)
Length=156
Score = 28.9 bits (63), Expect = 5.5
Identities = 14/47 (29%), Positives = 20/47 (42%), Gaps = 1/47 (2%)
Query 383 PAIYAERAGYDKLWHPACFVCSTCHE-LLVDMIYFWKNEKLYCGRHY 428
PA D ++H CF C C++ V +F KN + C Y
Sbjct 96 PAFEMVMRARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQMDY 142
>gi|2495078|sp|Q14831|MGR7_HUMAN Metabotropic glutamate receptor 7 precursor (mGluR7)
Length=915
Score = 28.5 bits (62), Expect = 7.2
Identities = 10/34 (29%), Positives = 17/34 (50%), Gaps = 0/34 (0%)
Query 154 GAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHD 187
G PC E C+G++ F C++C Q ++
Sbjct 538 GTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNE 571
>gi|57015279|sp|O14578|CTRO_HUMAN Citron Rho-interacting kinase (CRIK) (Rho-interacting, serine/threonine-protein
kinase 21)
Length=2027
Score = 28.5 bits (62), Expect = 7.2
Identities = 18/56 (32%), Positives = 26/56 (46%), Gaps = 10/56 (17%)
Query 155 APCLKCKEKCEGFELHFWRKICRNCKCGQEEHD----------VLLSNEEDRKVGK 200
+P L+ KE L W K+ RN K GQ+ D VL+ + E R+ G+
Sbjct 1432 SPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQ 1487
>gi|61211793|sp|Q7L1S5|CHST9_HUMAN Carbohydrate sulfotransferase 9 (N-acetylgalactosamine-4-O-sulfotransferase
2) (GalNAc-4-O-sulfotransferase 2) (GALNAc-4-ST2)
Length=438
Score = 28.5 bits (62), Expect = 7.2
Identities = 13/49 (26%), Positives = 26/49 (53%), Gaps = 0/49 (0%)
Query 198 VGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTY 246
V +++ + K+ L ++ G +KR +M+L ++ N+S N V Y
Sbjct 198 VSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHY 246
>gi|56757608|sp|P35251|RFC1_HUMAN Activator 1 140 kDa subunit (Replication factor C large subunit)
(A1 140 kDa subunit) (RF-C 140 kDa subunit) (Activator 1
large subunit) (DNA-binding protein PO-GA)
Length=1148
Score = 28.1 bits (61), Expect = 9.5
Identities = 30/126 (23%), Positives = 55/126 (43%), Gaps = 21/126 (16%)
Query 266 PKEKQPVAGSEGAQYRKKQLAKQLP--AHDQDPSKCHELSPRE---VKEMEQFVKKYKSE 320
P+++ S+ +Q K A ++ + + SK + +E KE+E K K
Sbjct 284 PRKQSKYESSKESQQHSKSSADKIGEVSSPKASSKLAIMKRKEESSYKEIEPVASKRKEN 343
Query 321 ALGV-GDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMK 379
A+ + G+ K P + +S+PA ++ + +E KRT Y Y L+ +
Sbjct 344 AIKLKGETKTPKKT--------------KSSPAKKESVSPEDSEKKRTNYQAYRSYLN-R 388
Query 380 EGDPAI 385
EG A+
Sbjct 389 EGPKAL 394
>gi|20140432|sp|O60308|K0562_HUMAN Protein KIAA0562
Length=925
Score = 28.1 bits (61), Expect = 9.5
Identities = 33/161 (20%), Positives = 59/161 (36%), Gaps = 25/161 (15%)
Query 308 KEMEQFVKKYKSEALGVGDVKLPC---EMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEH 364
K+ ++ +K + + + +++ E DA PK +I GG + A+G + EH
Sbjct 693 KQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPD----EH 748
Query 365 KRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYC 424
+C G+ + G D + C + + C + E L
Sbjct 749 YLDNLCIFC-------GERSESFTEEGLDLHYWKHCLMLTRCDHCKQVVEISSLTEHLLT 801
Query 425 GRHYCDSEK--PRCAGCDELIFSNEYTQAENQNWHLKHFCC 463
CD + +C C E +F E + H+KH C
Sbjct 802 ---ECDKKDGFGKCYRCSEAVFKEELPR------HIKHKDC 833
>gi|46577501|sp|Q8N122|RPTOR_HUMAN Regulatory associated protein of mTOR (Raptor) (P150 target of
rapamycin (TOR)-scaffold protein)
Length=1335
Score = 28.1 bits (61), Expect = 9.5
Identities = 15/68 (22%), Positives = 32/68 (47%), Gaps = 0/68 (0%)
Query 190 LSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWA 249
+ N +R D ++A+L SDG PM ++ +++ + + + + TV ++
Sbjct 627 VGNSAERTDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVALQFI 686
Query 250 PPVQNQAL 257
+N AL
Sbjct 687 EEEKNYAL 694
>gi|462010|sp|Q03111|ENL_HUMAN ENL protein
Length=559
Score = 28.1 bits (61), Expect = 9.5
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 5/78 (6%)
Query 266 PKEKQPVAGSEGAQYRKKQLAKQ---LPAHDQDPSKCHELSPREVKEME-QFVKKYKSEA 321
PK+ +P GS+ A + +K H + P K E S KE+E + K K +
Sbjct 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSE-SKSSSKELEREQAKSSKDTS 230
Query 322 LGVGDVKLPCEMDAQGPK 339
+G+ +LP E A PK
Sbjct 231 RKLGEGRLPKEEKAPPPK 248
>gi|19863363|sp|Q14587|ZN268_HUMAN Zinc finger protein 268 (Zinc finger protein HZF3)
Length=947
Score = 28.1 bits (61), Expect = 9.5
Identities = 18/66 (27%), Positives = 31/66 (46%), Gaps = 3/66 (4%)
Query 418 KNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHL--KHFCCFDCDSILAGEIY 475
K +L C + Y EKP C E FS++ +Q H K + C +C + + Y
Sbjct 260 KKSQLMCQQMYM-GEKPFGCSCCEKAFSSKSYLLVHQQTHAEEKPYGCNECGKDFSSKSY 318
Query 476 VMVNDK 481
++V+ +
Sbjct 319 LIVHQR 324
>gi|13959398|sp|Q9NQ38|ISK5_HUMAN Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial
Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate
peptide HF6478; Hemofiltrate peptide HF7665]
Length=1064
Score = 28.1 bits (61), Expect = 9.5
Identities = 14/46 (30%), Positives = 21/46 (45%), Gaps = 6/46 (13%)
Query 264 MLPKEKQPVAGSEGAQYRK------KQLAKQLPAHDQDPSKCHELS 303
+ PK+ +PV G +G Y + L +Q H + KC E S
Sbjct 1005 LCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS 1050
Database: Non-redundant SwissProt sequences
Posted date: Mar 15, 2006 2:23 AM
Number of letters in database: 7,391,856
Number of sequences in database: 13,628
Lambda K H
0.319 0.135 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 13628
Number of Hits to DB: 2744
Number of extensions: 127
Number of successful extensions: 1
Number of sequences better than 10: 0
Number of HSP's better than 10 without gapping: 0
Number of HSP's gapped: 1
Number of HSP's successfully gapped: 0
Length of query: 555
Length of database: 7391856
Length adjustment: 101
Effective length of query: 454
Effective length of database: 7391856
Effective search space: 3355902624
Effective search space used: 2731004312
T: 11
A: 40
X1: 16 (7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.4 bits)
S2: 61 (28.1 bits)