RID=1111068277-11279-126376647975.BLASTQ2, hg16_dna_19|geneid_v1.2_predicted_protein_19|770

BLASTP 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.
RID: 1111068277-11279-126376647975.BLASTQ2
Query= hg16_dna_19|geneid_v1.2_predicted_protein_19|770_AA (769 letters)
Database: Non-redundant SwissProt sequences 164,271 sequences; 60,490,055 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Taxonomy reports
Distribution of 118 Blast Hits on the Query Sequence


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20532378|sp|O15169|AXN1_HUMAN  Axin 1 (Axis inhibition pr...  1174   0.0   
gi|20532377|sp|O70239|AXN1_RAT  Axin 1 protein (Axis inhibit...  1035   0.0   
gi|20532379|sp|O35625|AXN1_MOUSE  Axin 1 (Axis inhibition pr...  1005   0.0   
gi|10719897|sp|O42400|AXN_CHICK  Axin (Axis inhibition protein)   884   0.0   
gi|10719898|sp|Q9YGY0|AXN_XENLA  Axin (Axis inhibition prote...   788   0.0   
gi|10719904|sp|P57094|AXN1_BRARE  Axin 1 (Axis inhibition pr...   749   0.0   
gi|12643949|sp|Q9Y2T1|AXN2_HUMAN  Axin 2 (Axis inhibition pr...   379   e-104 
gi|12643651|sp|O88566|AXN2_MOUSE  Axin 2 (Axis inhibition pr...   377   e-104 
gi|10719896|sp|O70240|AXN2_RAT  Axin 2 (Axis inhibition prot...   376   e-103 
gi|10719905|sp|P57095|AXN2_BRARE  Axin 2 (Axis inhibition pr...   351   4e-96 
gi|12643522|sp|Q9V407|AXN_DROME  Axin (Axis inhibition prote...    83   2e-15 
gi|1710136|sp|P49796|RGS3_HUMAN  Regulator of G-protein sign...    79   4e-14 
gi|18266777|sp|O43665|RGSA_HUMAN  Regulator of G-protein sig...    79   6e-14 
gi|15214217|sp|Q9DC04|RGS3_MOUSE  Regulator of G-protein sig...    77   2e-13 
gi|15214211|sp|Q99PG4|RGSI_MOUSE  Regulator of G-protein sig...    75   5e-13 
gi|15214214|sp|Q9CQE5|RGSA_MOUSE  Regulator of G-protein sig...    75   5e-13 
gi|3914625|sp|O15539|RGS5_HUMAN  Regulator of G-protein sign...    75   7e-13 
gi|15214228|sp|Q9NS28|RGSI_HUMAN  Regulator of G-protein sig...    74   1e-12 
gi|19862758|sp|Q08116|RGS1_HUMAN  Regulator of G-protein sig...    74   1e-12 
gi|19855046|sp|O08850|RGS5_MOUSE  Regulator of G-protein sig...    72   4e-12 
gi|13124465|sp|P57771|RGS8_HUMAN  Regulator of G-protein sig...    72   6e-12 
gi|51701807|sp|Q8BXT1|RGS8_MOUSE  Regulator of G-protein sig...    72   6e-12 
gi|13124774|sp|P49800|RGS5_RAT  Regulator of G-protein signa...    72   6e-12 
gi|1710149|sp|P49799|RGS4_RAT  Regulator of G-protein signal...    71   1e-11 
gi|6093964|sp|P49804|RGS8_RAT  Regulator of G-protein signal...    71   1e-11 
gi|15214234|sp|Q9QZB0|RGSH_MOUSE  Regulator of G-protein sig...    69   4e-11 
gi|14916689|sp|Q9JHX0|RGS2_RAT  Regulator of G-protein signa...    69   4e-11 
gi|6093966|sp|P56700|RGSG_RAT  Regulator of G-protein signal...    69   4e-11 
gi|2500167|sp|O08899|RGS4_MOUSE  Regulator of G-protein sign...    69   5e-11 
gi|19855045|sp|O08849|RGS2_MOUSE  Regulator of G-protein sig...    69   6e-11 
gi|1710146|sp|P49798|RGS4_HUMAN  Regulator of G-protein sign...    69   6e-11 
gi|729545|sp|P41220|RGS2_HUMAN  Regulator of G-protein signa...    68   8e-11 
gi|15214223|sp|Q9JL25|RGS1_MOUSE  Regulator of G-protein sig...    68   8e-11 
gi|2500171|sp|P97428|RGSG_MOUSE  Regulator of G-protein sign...    67   1e-10 
gi|3914630|sp|O46471|RGSG_BOVIN  Regulator of G-protein sign...    66   3e-10 
gi|15214232|sp|Q9PWA0|RGSH_CHICK  Regulator of G-protein sig...    66   4e-10 
gi|15214235|sp|Q9QZB1|RGSK_MOUSE  Regulator of G-protein sig...    65   7e-10 
gi|41017772|sp|Q8WQC0|RGS7_CAEEL  Regulator of G-protein sig...    65   9e-10 
gi|51701812|sp|Q8K443|RGS13_MOUSE  Regulator of G-protein si...    64   1e-09 
gi|3914624|sp|O15492|RGS16_HUMAN  Regulator of G-protein sig...    64   2e-09 
gi|15214233|sp|Q9PWA1|RGSK_CHICK  Regulator of G-protein sig...    64   2e-09 
gi|15214238|sp|Q9UGC6|RGSH_HUMAN  Regulator of G-protein sig...    63   3e-09 
gi|18266795|sp|O76081|RGSK_HUMAN  Regulator of G-protein sig...    63   3e-09 
gi|19855059|sp|O43566|RGSE_HUMAN  Regulator of G-protein sig...    62   4e-09 
gi|1730186|sp|P49795|RGS19_HUMAN  Regulator of G-protein sig...    62   6e-09 
gi|2500170|sp|O08773|RGSE_RAT  Regulator of G-protein signal...    61   1e-08 
gi|3914634|sp|P79348|RGSK_BOVIN  Regulator of G-protein sign...    61   1e-08 
gi|3914636|sp|P97492|RGSE_MOUSE  Regulator of G-protein sign...    61   1e-08 
gi|15214216|sp|Q9CX84|RGSJ_MOUSE  Regulator of G-protein sig...    60   2e-08 
gi|3914622|sp|O14921|RGS13_HUMAN  Regulator of G-protein sig...    60   2e-08 
gi|3913710|sp|O70521|RGSJ_RAT  Regulator of G-protein signal...    59   5e-08 
gi|1731187|sp|P49808|RGS2_CAEEL  Regulator of G-protein sign...    55   7e-07 
gi|20141720|sp|P34295|RGS1_CAEEL  Regulator of G protein sig...    52   5e-06 
gi|2500169|sp|O08774|RGSC_RAT  Regulator of G-protein signal...    50   2e-05 
gi|3914623|sp|O14924|RGSC_HUMAN  Regulator of G-protein sign...    50   2e-05 
gi|15214250|sp|Q9Z2H1|RGSB_MOUSE  Regulator of G-protein sig...    50   3e-05 
gi|6919871|sp|O14641|DVL2_HUMAN  Segment polarity protein di...    49   5e-05 
gi|22096404|sp|Q18312|RGS3_CAEEL  Regulator of G protein sig...    49   5e-05 
gi|6919872|sp|Q60838|DVL2_MOUSE  Segment polarity protein di...    49   5e-05 
gi|6919875|sp|Q92997|DVL3_HUMAN  Segment polarity protein di...    49   7e-05 
gi|6919873|sp|Q61062|DVL3_MOUSE  Segment polarity protein di...    49   7e-05 
gi|6174947|sp|O94810|RGSB_HUMAN  Regulator of G-protein sign...    47   2e-04 
gi|1706527|sp|P51140|DSH_DROME  Segment polarity protein dis...    47   2e-04 
gi|8489001|sp|O54828|RGS9_MOUSE  Regulator of G-protein sign...    46   3e-04 
gi|8489000|sp|P49805|RGS9_RAT  Regulator of G-protein signal...    46   3e-04 
gi|8475983|sp|O75916|RGS9_HUMAN  Regulator of G-protein sign...    45   7e-04 
gi|3914628|sp|O46469|RGS9_BOVIN  Regulator of G-protein sign...    45   7e-04 
gi|20141291|sp|Q9WVB9|DVL1_RAT  Segment polarity protein dis...    44   0.002 
gi|6919870|sp|O14640|DVL1_HUMAN  Segment polarity protein di...    44   0.002 
gi|1706528|sp|P54792|DVL1L_HUMAN  Segment polarity protein d...    44   0.002 
gi|1706529|sp|P51141|DVL1_MOUSE  Segment polarity protein di...    44   0.002 
gi|20141813|sp|Q9Y5W7|SNXE_HUMAN  Sorting nexin 14                 42   0.006 
gi|1706621|sp|P49809|EG10_CAEEL  Regulator of G-protein sign...    42   0.006 
gi|114151|sp|P21146|ARBK1_BOVIN  Beta-adrenergic receptor ki...    41   0.011 
gi|1706530|sp|P51142|DVL2_XENLA  Segment polarity protein di...    41   0.014 
gi|17380284|sp|P49802|RGS7_HUMAN  Regulator of G-protein sig...    40   0.031 
gi|114152|sp|P25098|ARBK1_HUMAN  Beta-adrenergic receptor ki...    39   0.040 
gi|3121776|sp|Q64682|ARBK1_MESAU  Beta-adrenergic receptor k...    39   0.040 
gi|47605537|sp|Q99MK8|ARBK1_MOUSE  Beta-adrenergic receptor ...    39   0.040 
gi|114153|sp|P26817|ARBK1_RAT  Beta-adrenergic receptor kina...    39   0.052 
gi|3914629|sp|O46470|RGS7_BOVIN  Regulator of G-protein sign...    39   0.052 
gi|13124775|sp|P49803|RGS7_RAT  Regulator of G-protein signa...    39   0.069 
gi|126752|sp|P26645|MACS_MOUSE  Myristoylated alanine-rich C...    37   0.15  
gi|29337232|sp|Q18563|YCAK_CAEEL  Hypothetical protein C41G1...    37   0.26  
gi|23822106|sp|Q99PL5|RRB1_MOUSE  Ribosome-binding protein 1...    36   0.34  
gi|266495|sp|P30009|MACS_RAT  Myristoylated alanine-rich C-k...    35   0.76  
gi|24418867|sp|Q9Y5W8|SNXD_HUMAN  Sorting nexin 13 (RGS doma...    35   0.76  
gi|114154|sp|P26818|ARBK2_BOVIN  Beta-adrenergic receptor ki...    34   1.3   
gi|114155|sp|P26819|ARBK2_RAT  Beta-adrenergic receptor kina...    34   1.7   
gi|118938|sp|P13922|DRTS_PLAFK  Bifunctional dihydrofolate r...    33   2.2   
gi|3915327|sp|O51067|Y038_BORBU  Hypothetical protein BB0038       33   3.8   
gi|2851457|sp|Q40963|MP5B_PHLPR  Pollen allergen Phl p 5b pr...    32   4.9   
gi|543848|sp|P35626|ARBK2_HUMAN  Beta-adrenergic receptor ki...    32   4.9   
gi|60389868|sp|Q810W7|MAST1_RAT  Microtubule-associated seri...    32   6.4   
gi|3024533|sp|P97844|RGS1_RAT  Regulator of G-protein signal...    32   6.4   
gi|22261815|sp|P49758|RGS6_HUMAN  Regulator of G-protein sig...    32   6.4   
gi|46397733|sp|Q8SX83|SPEN_DROME  Split ends protein               32   8.4   
gi|6093748|sp|O13898|PMTX_SCHPO  Probable dolichyl-phosphate...    32   8.4   
gi|9911089|sp|P03764|STF_LAMBD  Side tail fiber protein            32   8.4   


Alignments

>gi|20532378|sp|O15169|AXN1_HUMAN   Axin 1 (Axis inhibition protein 1) (hAxin)
          Length = 862

 Score = 1174 bits (3037), Expect = 0.0
 Identities = 581/658 (88%), Positives = 582/658 (88%)

Query: 21  MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT 80
           MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT
Sbjct: 1   MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT 60

Query: 81  PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 140
           PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA
Sbjct: 61  PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 120

Query: 141 CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA 200
           CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA
Sbjct: 121 CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA 180

Query: 201 MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPT 260
           MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQ            YLPT
Sbjct: 181 MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPT 240

Query: 261 LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP 320
           LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP
Sbjct: 241 LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP 300

Query: 321 VNPYYVNAGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRIRKQHRREMQESV 380
           VNPYYVNAGYALAPATSANDSEQQ               VDGIPPYRIRKQHRREMQESV
Sbjct: 301 VNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESV 360

Query: 381 QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXX 440
           QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQ                    
Sbjct: 361 QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEE 420

Query: 441 XXXXXXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLR 500
                         CHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLR
Sbjct: 421 EGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLR 480

Query: 501 TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLXXXXXXXXXXX 560
           TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGL           
Sbjct: 481 TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHVH 540

Query: 561 XSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGV 620
            STARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGV
Sbjct: 541 HSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGV 600

Query: 621 ACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRK 678
           ACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHG+   RK
Sbjct: 601 ACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRK 658



 Score =  199 bits (506), Expect = 2e-50
 Identities = 97/97 (100%), Positives = 97/97 (100%)

Query: 673 TRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFK 732
           TRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFK
Sbjct: 766 TRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFK 825

Query: 733 KVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           KVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD
Sbjct: 826 KVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 862



>gi|20532377|sp|O70239|AXN1_RAT   Axin 1 protein (Axis inhibition protein 1) (rAxin)
          Length = 827

 Score = 1035 bits (2675), Expect = 0.0
 Identities = 544/829 (65%), Positives = 588/829 (70%), Gaps = 82/829 (9%)

Query: 21  MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT 80
           MN+QEQGFPLDLGASFTEDAPRPPVPGEEGELVSTD RP ++SFCSGKG  IK ETSTAT
Sbjct: 1   MNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTAT 60

Query: 81  PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 140
           PRRSDLDLGYEPEGSASPTPPYL+WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA
Sbjct: 61  PRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 120

Query: 141 CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA 200
           C+GFRKLEPCDSNEEKRLKLARAIYRKYILD+NGIVSRQTKPATKSFIK C+MKQ IDPA
Sbjct: 121 CSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPA 180

Query: 201 MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPT 260
           MFDQAQTEIQ+TMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQ            YLPT
Sbjct: 181 MFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPT 240

Query: 261 LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP 320
           LNEDEEWKCDQD DEDDGRD+ PP RL QKLLLETAAPR  SSRRY+EGRE RYGSWREP
Sbjct: 241 LNEDEEWKCDQDADEDDGRDSVPPSRLTQKLLLETAAPRAPSSRRYNEGRELRYGSWREP 300

Query: 321 VNPYYVNAGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRIRKQHRREMQESV 380
           VNPYYVN+GYALAPATSANDSEQQ               VDGIPPYRIRKQHRREMQESV
Sbjct: 301 VNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESV 360

Query: 381 QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXX 440
           QVNGRVPLPHIPRTYR+PKE+RVEPQKFAEELIHRLEAVQ                    
Sbjct: 361 QVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEE 420

Query: 441 XXXXXXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLR 500
                          HKLP  PAWHHFPPR VDMGC+GLRDAHEENPESILDEHVQRV+R
Sbjct: 421 EGEDGEMPSGPMAS-HKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMR 479

Query: 501 TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLXXXXXXXXXXX 560
           TPG QSPGPGHRSPDSGHVAK  V LGG ASGHGKH PK G KLD+AGL           
Sbjct: 480 TPGCQSPGPGHRSPDSGHVAKTAV-LGGTASGHGKHAPKLGLKLDSAGLHHHRHVHHHVH 538

Query: 561 XSTAR----------------------------PKEQVEAEATRRAQSSFAWGLEPHSHG 592
            ++AR                            P+   E+  T  +    A+G +  +  
Sbjct: 539 HNSARPKEQMEAEAARRVQSSFSWGPETHGHAKPRSYSESTGTNPSAGDLAFGGKASAPS 598

Query: 593 ARSRGYSESVGAA----PNASDGLAHSGKV-------------------GVACKRNAKKA 629
            R+   +ES   A    P+ ++    + K+                   G +  R  +  
Sbjct: 599 KRNTKKAESGKNASAEVPSTTEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGMRKQQAH 658

Query: 630 ESGKSASTEVPGASE---DAEKNQKIM--------------------------QWIIEGE 660
           ES +  S E PGA      A+    +                           +  +E E
Sbjct: 659 ESSRPLSIERPGAVHPWVSAQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEE 718

Query: 661 KEISRHRRTGHGTRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKEL 720
           ++ +    +   T+SQRK GGGSA PCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKEL
Sbjct: 719 EKRANKLPSKQRTKSQRKAGGGSAPPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKEL 778

Query: 721 LTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           LTKKGSYRYYFKKVSDEFDCGVVFEEVREDEA+LPVFEEKIIGKVEKVD
Sbjct: 779 LTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAILPVFEEKIIGKVEKVD 827



>gi|20532379|sp|O35625|AXN1_MOUSE   Axin 1 (Axis inhibition protein 1) (Fused protein)
          Length = 863

 Score = 1005 bits (2599), Expect = 0.0
 Identities = 500/658 (75%), Positives = 527/658 (80%), Gaps = 4/658 (0%)

Query: 21  MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT 80
           MN+QEQGFPLDLGASFTEDAPRPPVPGEEGELVSTD RP ++SFCSGKG  IK ETSTAT
Sbjct: 1   MNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRPVNHSFCSGKGTSIKSETSTAT 60

Query: 81  PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 140
           PRRSDLDLGYEPEGSASPTPPYL+WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA
Sbjct: 61  PRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 120

Query: 141 CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA 200
           C+GFRKLEPCDSNEEKRLKLARAIYRKYILD+NGIVSRQTKPATKSFIK C+MKQ IDPA
Sbjct: 121 CSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGIVSRQTKPATKSFIKDCVMKQQIDPA 180

Query: 201 MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPT 260
           MFDQAQTEIQ+TMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQ            YLPT
Sbjct: 181 MFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGMSGYLPT 240

Query: 261 LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP 320
           LNEDEEWKCDQD DEDDGRD  PP RL QKLLLETAAPR  SSRRY+EGRE RYGSWREP
Sbjct: 241 LNEDEEWKCDQDADEDDGRDPLPPSRLTQKLLLETAAPRAPSSRRYNEGRELRYGSWREP 300

Query: 321 VNPYYVNAGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRIRKQHRREMQESV 380
           VNPYYVN+GYALAPATSANDSEQQ               VDGIPPYRIRKQHRREMQES+
Sbjct: 301 VNPYYVNSGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESI 360

Query: 381 QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXX 440
           QVNGRVPLPHIPRTYR+PKE+RVEPQKFAEELIHRLEAVQ                    
Sbjct: 361 QVNGRVPLPHIPRTYRMPKEIRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMEE 420

Query: 441 XXXXXXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLR 500
                          HKLP  PAWHHFPPR VDMGC+GLRDAHEENPESILDEHVQRV+R
Sbjct: 421 EGEDGEMPSGPMAS-HKLPSVPAWHHFPPRYVDMGCSGLRDAHEENPESILDEHVQRVMR 479

Query: 501 TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLXXXXXXXXXXX 560
           TPG QSPGPGHRSPDSGHVAK  V LGG ASGHGKHVPK G KLD AGL           
Sbjct: 480 TPGCQSPGPGHRSPDSGHVAKTAV-LGGTASGHGKHVPKLGLKLDTAGLHHHRHVHHHVH 538

Query: 561 XSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGV 620
            ++ARPKEQ+EAE  RR QSSF+WG E H H A+ R YSE+ G   +A D L   GK   
Sbjct: 539 HNSARPKEQMEAEVARRVQSSFSWGPETHGH-AKPRSYSENAGTTLSAGD-LPFGGKTSA 596

Query: 621 ACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRK 678
             KRN KKAESGK+A+ EVP  +EDAEKNQKIMQWIIEGEKEISRHR+ GHG+   RK
Sbjct: 597 PSKRNTKKAESGKNANAEVPSTTEDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGLRK 654



 Score =  191 bits (484), Expect = 8e-48
 Identities = 92/97 (94%), Positives = 93/97 (95%)

Query: 673 TRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFK 732
           T+SQRK GGGSA PCDSIVV YYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFK
Sbjct: 767 TKSQRKAGGGSAPPCDSIVVGYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFK 826

Query: 733 KVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           KVSDEFDCGVVFEEVREDE VLPVFEEKIIGKVEKVD
Sbjct: 827 KVSDEFDCGVVFEEVREDEPVLPVFEEKIIGKVEKVD 863



>gi|10719897|sp|O42400|AXN_CHICK   Axin (Axis inhibition protein)
          Length = 841

 Score =  884 bits (2283), Expect = 0.0
 Identities = 439/668 (65%), Positives = 498/668 (74%), Gaps = 10/668 (1%)

Query: 21  MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT 80
           MNIQ +GFPLDLG SFTEDAPRPPVPGEEGELVSTDPRP S+ F S K   ++ ETSTAT
Sbjct: 1   MNIQGKGFPLDLGRSFTEDAPRPPVPGEEGELVSTDPRPVSHGFYSSKSDAVRNETSTAT 60

Query: 81  PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 140
           PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGI+LFRTFLKQE CADLLDFWFA
Sbjct: 61  PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGINLFRTFLKQEDCADLLDFWFA 120

Query: 141 CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA 200
           C+GFRKLEPC SNEEKRLKLA+AIY+KYILDNNGIVSRQ KPATKSFIK C+MK  IDP 
Sbjct: 121 CSGFRKLEPCVSNEEKRLKLAKAIYKKYILDNNGIVSRQIKPATKSFIKDCVMKLQIDPD 180

Query: 201 MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPT 260
           MFDQAQTEIQ  +E+NTYP FLKSDIYLEYTRTG ESPK+ SD             YLPT
Sbjct: 181 MFDQAQTEIQCMIEDNTYPLFLKSDIYLEYTRTGGESPKIYSDPSSGSGTGKGLPGYLPT 240

Query: 261 LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP 320
           LNEDEEWKCDQD + +  RD+AP  RL QKLLLETA  R +S+RRYSEGREFR+GSWREP
Sbjct: 241 LNEDEEWKCDQDTEPEASRDSAPSSRLTQKLLLETATQRATSTRRYSEGREFRHGSWREP 300

Query: 321 VNPYYVNAGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRIRKQHRREMQESV 380
           VNPYYVN GYA+APATSANDSEQQ               +DGIPPYR+RKQHRREMQES 
Sbjct: 301 VNPYYVNTGYAMAPATSANDSEQQSMSSDADTMSLTDSSIDGIPPYRLRKQHRREMQESA 360

Query: 381 QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXX 440
           + NGRVPLPHIPRTYR+PK++ VEP+KFA ELI+RLE VQ                    
Sbjct: 361 KANGRVPLPHIPRTYRMPKDIHVEPEKFAAELINRLEEVQKEREAEEKLEERLKRVRAEE 420

Query: 441 XXXXXXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAG--LRDAHEENPESILDEHVQRV 498
                          HK+P A  +HHF PR  +MGCAG  +RDAHEENPESILDEHVQRV
Sbjct: 421 EGEDADISSGPSVISHKMPSAQPFHHFAPRYSEMGCAGMQMRDAHEENPESILDEHVQRV 480

Query: 499 LRTPGRQSPGPGH-----RSPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGL-XXX 552
           ++TPG QSPGPG      RSP+SGH+ K+   LG    GHGKH  KSG KLDAA L    
Sbjct: 481 MKTPGCQSPGPGRHSPKPRSPESGHLGKLSGTLGTIPPGHGKHTTKSGMKLDAANLYHHK 540

Query: 553 XXXXXXXXXSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGL 612
                    S  +PKEQ+EAEAT+R Q+SFAW ++ H++  +SR YSE++G AP   D L
Sbjct: 541 HVYHHIHHHSMMKPKEQIEAEATQRVQNSFAWNVDSHNYATKSRNYSENLGMAPVPMDSL 600

Query: 613 AHSGKVGVACKRNAKKAESGKS--ASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTG 670
            +SGK  +  KRN KK +SGKS  A+ E+PG+ ED E+NQKI+QWIIEGEKEISRH++T 
Sbjct: 601 GYSGKASLLSKRNIKKTDSGKSDGANYEMPGSPEDVERNQKILQWIIEGEKEISRHKKTN 660

Query: 671 HGTRSQRK 678
           HG+   +K
Sbjct: 661 HGSSGVKK 668



 Score =  174 bits (442), Expect = 6e-43
 Identities = 78/96 (81%), Positives = 91/96 (94%)

Query: 674 RSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKK 733
           + Q++ G G++QPC++IVVAYYFCGEPIPYRTLV+GR VTLGQFKELLTKKG+YRYYFKK
Sbjct: 746 KPQKRPGSGASQPCENIVVAYYFCGEPIPYRTLVKGRVVTLGQFKELLTKKGNYRYYFKK 805

Query: 734 VSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           VSDEFDCGVVFEEVRED+ +LP+FEEKIIGKVEK+D
Sbjct: 806 VSDEFDCGVVFEEVREDDTILPIFEEKIIGKVEKID 841



>gi|10719898|sp|Q9YGY0|AXN_XENLA   Axin (Axis inhibition protein) (xAxin)
          Length = 842

 Score =  788 bits (2036), Expect = 0.0
 Identities = 397/668 (59%), Positives = 473/668 (70%), Gaps = 10/668 (1%)

Query: 21  MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTAT 80
           M+++ +GFPLDLG SFTEDAPRPPVPGEEGEL++TD RP S+++ S K  GIK ETSTAT
Sbjct: 1   MSVKGKGFPLDLGGSFTEDAPRPPVPGEEGELITTDQRPFSHTYYSLKNDGIKNETSTAT 60

Query: 81  PRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFA 140
           PRR DLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGI LFRTFL+QE CADLLDFWFA
Sbjct: 61  PRRPDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGIHLFRTFLQQENCADLLDFWFA 120

Query: 141 CTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA 200
           C+GFRKLEP DS  EKRLKLA+AIY+KY+LD+NGIVSRQ KPATKSFIK C+++Q IDPA
Sbjct: 121 CSGFRKLEPNDSKVEKRLKLAKAIYKKYVLDSNGIVSRQIKPATKSFIKDCVLRQQIDPA 180

Query: 201 MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPT 260
           MFDQAQ EIQ+ ME+NTYP FLKSDIYLEYT  G ESPK  SDQ            YLPT
Sbjct: 181 MFDQAQMEIQSMMEDNTYPVFLKSDIYLEYTTIGGESPKNYSDQSSGSGTGKGPSGYLPT 240

Query: 261 LNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREP 320
           LNEDEEW+CDQ  + +  R+  P     QKL L++++    S+RR S+GREFR G+WREP
Sbjct: 241 LNEDEEWRCDQGGEHERERECIPSSLFSQKLALDSSSHCAGSNRRLSDGREFRPGTWREP 300

Query: 321 VNPYYVNAGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRIRKQHRREMQESV 380
           VNPYYVN GYA AP TSANDSEQQ               VDGIPPYR+RK +RREMQES 
Sbjct: 301 VNPYYVNTGYAGAPVTSANDSEQQSMSSDADTMSLTDSSVDGIPPYRLRKHYRREMQESA 360

Query: 381 QVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXX 440
             NGR PLPHIPRTY +PK++ V+P+KFA ELI RLE V                     
Sbjct: 361 NANGRGPLPHIPRTYHMPKDIHVDPEKFAAELISRLEGVLRDREAEQKLEERLKRVRAEE 420

Query: 441 XXXXXXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAG--LRDAHEENPESILDEHVQRV 498
                          HKLP  P  HHF  R  + GC G  +RDAHEENPESILDEHVQRV
Sbjct: 421 EGDDGDVSSGPSVISHKLPSGPPMHHFNSRYSETGCVGMQIRDAHEENPESILDEHVQRV 480

Query: 499 LRTPGRQSPGPGHRSPDS----GHVAK-MPVALGGAASGHGKHVPKSGAKLDAAGL-XXX 552
           ++TPG QSPG G  SP S    GH++K +P +LG   +GHGKH  KS AK+D+  L    
Sbjct: 481 MKTPGCQSPGTGRHSPKSRSPDGHLSKTLPGSLGTMQTGHGKHSSKSTAKVDSGNLHHHK 540

Query: 553 XXXXXXXXXSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGL 612
                       +PKEQ++ E+T+R Q++F W +E H++  +SR Y+ES+G APN  D L
Sbjct: 541 HVYHHVHHHGGVKPKEQIDGESTQRVQTNFPWNVESHNYATKSRNYAESMGMAPNPMDSL 600

Query: 613 AHSGKVGVACKRNAKKAESGK--SASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTG 670
           A+SGKV +  KRNAKKA+ GK  SAS E+P   ED+E++QKI+QWI+EGEKEI RH+++ 
Sbjct: 601 AYSGKVSMLSKRNAKKADLGKSESASHEMPVVPEDSERHQKILQWIMEGEKEIIRHKKSN 660

Query: 671 HGTRSQRK 678
           H + S +K
Sbjct: 661 HSSSSAKK 668



 Score =  166 bits (421), Expect = 2e-40
 Identities = 75/96 (78%), Positives = 88/96 (91%)

Query: 674 RSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKK 733
           + Q+K     +QPCD+IVVAYYFCGEPIPYRT+V+GR VTLGQFKELLTKKG+YRYYFKK
Sbjct: 747 KPQKKNVSAPSQPCDNIVVAYYFCGEPIPYRTMVKGRVVTLGQFKELLTKKGNYRYYFKK 806

Query: 734 VSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           VSDEFDCGVVFEEVRED+ +LP++EEKIIG+VEK+D
Sbjct: 807 VSDEFDCGVVFEEVREDDMILPIYEEKIIGQVEKID 842



>gi|10719904|sp|P57094|AXN1_BRARE   Axin 1 (Axis inhibition protein 1)
          Length = 835

 Score =  749 bits (1933), Expect = 0.0
 Identities = 422/836 (50%), Positives = 495/836 (59%), Gaps = 90/836 (10%)

Query: 21  MNIQEQG--FPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETST 78
           M++ E+G  +  DLG+SFTEDAPRPPVPGEEG+LVS+D R  ++SF S K   +K E S 
Sbjct: 3   MSVNEKGICYLPDLGSSFTEDAPRPPVPGEEGDLVSSDGRQYNHSFYSSKSDSLKNEASI 62

Query: 79  ATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFW 138
           ATPRR DLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGI LFRTFLKQE CAD+LDFW
Sbjct: 63  ATPRRPDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGIHLFRTFLKQEECADMLDFW 122

Query: 139 FACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLID 198
           FAC+GFRK E  D NE K LKLA+AIY+KYILDNNGIVSRQ KPATKSFIK C+MK  ID
Sbjct: 123 FACSGFRKQEANDGNE-KMLKLAKAIYKKYILDNNGIVSRQIKPATKSFIKDCVMKLHID 181

Query: 199 PAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYL 258
           PAMFDQAQTEIQ  MEENTYP FLKSDIYLEYTRTG ESPK+ SDQ            YL
Sbjct: 182 PAMFDQAQTEIQTMMEENTYPLFLKSDIYLEYTRTGGESPKLFSDQSSVSGNGKVLPGYL 241

Query: 259 PTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWR 318
           PT+ ED EW+CDQ+ ++    D  P  RL QKLLLET   RV++S+RY + RE+R+ SWR
Sbjct: 242 PTVIEDVEWRCDQEEEQIAESDPTPSNRLTQKLLLETVPQRVANSKRYQDNREYRHASWR 301

Query: 319 EPVNPYYVNAGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRIRKQHRREMQE 378
           EPVNPYYVN+GYALAPATSANDSEQQ               VDG+PPYR RK HRRE+ E
Sbjct: 302 EPVNPYYVNSGYALAPATSANDSEQQSMSSDADTLSLTDSSVDGVPPYRYRKPHRREIHE 361

Query: 379 SVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXX 438
           S +VNGRVPLPHIPRT R+PK++ VEP+KFA ELI RLE V                   
Sbjct: 362 SAKVNGRVPLPHIPRTNRIPKDIHVEPEKFAAELISRLEGVLREREAQEKLEERLKRVRL 421

Query: 439 XXXXXXXXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAGL--RDAHEENPESILDEHVQ 496
                            H++PPA    H+  R  +M   GL  RDAHEENPESILDEHVQ
Sbjct: 422 EEEGDDADISTGPSLANHRVPPAVHVQHYGGRYSEMSYNGLQLRDAHEENPESILDEHVQ 481

Query: 497 RVLRTPGRQSPG-------------------PGHRSPDSGHVAKMPVALG----GAASGH 533
           RV++TPG QSPG                   PG   P SG   K     G     A   H
Sbjct: 482 RVMKTPGCQSPGTGRHSPKSRSPDGLPAGKIPGLMMPLSGGQGKHQARQGPKGEAAHLHH 541

Query: 534 GKHV----------PKSGAKLDAAGLXXXXX----------------------------- 554
            KH+          PK  A+ +AA +                                  
Sbjct: 542 HKHIHHTHYAAAGKPKEQAEAEAARMHGGFAWNTEQHHYGPKSRNYADGMSVGPNTMDPM 601

Query: 555 -XXXXXXXSTARP------------KEQVEAEATRRAQSSFAWGLEPHSHGARSR----- 596
                    + RP            +E + A+   R Q    W +E      R +     
Sbjct: 602 GYSSKGSTLSKRPVRKGEDGRNFEMREPLPADDMERNQKILQWMMEGEKEAGRYKRSPYG 661

Query: 597 ---GYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIM 653
              G  ++ G  P     +   G V        +          + P    +   N   +
Sbjct: 662 SISGPKKAQGHEPARPSSVERLGAVHPWVTAQLRNNVQPSHPFIQDPTMPPNPAPNP--L 719

Query: 654 QWIIEGEKEISRHRRTGHGTRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVT 713
             + E  + +   RR     +++++      QPC++I VAYYFCGEPIPYRT V+GR VT
Sbjct: 720 TQLEEARRRLEEERRKSGTLQAKQRHKNMKKQPCENITVAYYFCGEPIPYRTSVKGRIVT 779

Query: 714 LGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           LGQFKELLTKKGSY+YYFKKVS EFDCGVVFEEVRED+A+LP+FEEKIIGKVEKVD
Sbjct: 780 LGQFKELLTKKGSYKYYFKKVSYEFDCGVVFEEVREDDAILPIFEEKIIGKVEKVD 835



>gi|12643949|sp|Q9Y2T1|AXN2_HUMAN   Axin 2 (Axis inhibition protein 2) (Conductin) (Axin-like protein)
           (Axil)
          Length = 843

 Score =  379 bits (972), Expect = e-104
 Identities = 256/684 (37%), Positives = 349/684 (51%), Gaps = 70/684 (10%)

Query: 31  DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGY 90
           D  +SF EDAPRPPVPGEEGE     P         GKG   K  + ++  RR++  LG 
Sbjct: 12  DPSSSFREDAPRPPVPGEEGETPPCQPGV-------GKGQVTKPMSVSSNTRRNEDGLG- 63

Query: 91  EPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPC 150
           EPEG ASP  P  +W +SLHSLL DQDG  LFRTFL++E C D LDFWFAC GFR++   
Sbjct: 64  EPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLK 123

Query: 151 DSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQ 210
           D+   K L++A+AIY++YI +NN IVS+Q KPATK++I+  I KQ ID  MFDQAQTEIQ
Sbjct: 124 DT---KTLRVAKAIYKRYI-ENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQ 179

Query: 211 ATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPTLNEDEEWKCD 270
           + MEEN Y  FL SDIYLEY R+G E+    S+             YLPTLNE+EEW C 
Sbjct: 180 SVMEENAYQMFLTSDIYLEYVRSGGENTAYMSN--GGLGSLKVVCGYLPTLNEEEEWTCA 237

Query: 271 QDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWR--EPVNPYYVNA 328
               +            P  + L +   R ++S R +E  +  Y S++  +PVNPY++ +
Sbjct: 238 DFKCK----------LSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGS 287

Query: 329 GYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRI--RKQHRREMQESVQVNGRV 386
           GY  APATSANDSE                 VDGIPPYR+  +KQ +REM  SV+ NG+V
Sbjct: 288 GYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQV 347

Query: 387 PLPHIPRTYRVPKEVR-VEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXXXXXXX 445
            LPH PRT+R+PKE+  VEP  FA ELI RLE ++                         
Sbjct: 348 SLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLK------LELESRHSLEERLQQIRED 401

Query: 446 XXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGRQ 505
                     +    AP  H  P   +  G      ++EE+P++ILD+H+ RVL+TPG Q
Sbjct: 402 EEREGSELTLNSREGAPTQH--PLSLLPSG------SYEEDPQTILDDHLSRVLKTPGCQ 453

Query: 506 SPG-----PGHRSPDSGH------VAKMPVA--LGGAASGHGKHVPKSGAKLDAAGLXXX 552
           SPG     P  RSPD  H       + +P    L  AA+  G      G           
Sbjct: 454 SPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKH 513

Query: 553 XXXXXXXXXSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGL 612
                    +  + KE++EAEAT+R       G E + + ++ + +S++    P+   G 
Sbjct: 514 VHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCY-SKCKSHSKAPETMPSEQFG- 571

Query: 613 AHSGKVGVACKRNAKKAESGKSASTEVPGA----------SEDAEKNQKIMQWIIEGEKE 662
               +     KRN K  E G +      GA           E+ +++Q + QW++E E++
Sbjct: 572 --GSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQ 629

Query: 663 ISRHRRTGHGTRSQRKVGGGSAQP 686
                 +   T+    +    + P
Sbjct: 630 SKPKPHSAQSTKKAYPLESARSSP 653



 Score =  126 bits (317), Expect = 2e-28
 Identities = 65/149 (43%), Positives = 90/149 (60%), Gaps = 5/149 (3%)

Query: 621 ACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRKVG 680
           AC+R    AE  K        AS+  ++N      +  G    S         +  +K+ 
Sbjct: 700 ACRR---LAEVSKPPKQRCCVASQQRDRNHSAT--VQTGATPFSNPSLAPEDHKEPKKLA 754

Query: 681 GGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDC 740
           G  A     +VV Y+FCGE IPYR +++ +++TLG FKE L+KKG+YRYYFKK SDEF C
Sbjct: 755 GVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFAC 814

Query: 741 GVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           G VFEE+ EDE VLP++E +I+GKVE++D
Sbjct: 815 GAVFEEIWEDETVLPMYEGRILGKVERID 843



>gi|12643651|sp|O88566|AXN2_MOUSE   Axin 2 (Axis inhibition protein 2) (Conductin) (Axin-like protein)
           (Axil)
          Length = 840

 Score =  377 bits (968), Expect = e-104
 Identities = 260/688 (37%), Positives = 345/688 (50%), Gaps = 72/688 (10%)

Query: 31  DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGY 90
           D  +SF EDAPRPPVPGEEGE     P         GK    K    ++  RR++  LG 
Sbjct: 12  DPSSSFREDAPRPPVPGEEGETPPCQPSV-------GKVQSTKPMPVSSNARRNEDGLG- 63

Query: 91  EPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPC 150
           EPEG ASP  P  +W +SLHSLL DQDG  LFRTFL++E C D LDFWFAC GFR++   
Sbjct: 64  EPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLK 123

Query: 151 DSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQ 210
           D+   K L++A+AIY++YI +NN +VS+Q KPATK++I+  I KQ I   MFDQAQTEIQ
Sbjct: 124 DT---KTLRVAKAIYKRYI-ENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTEIQ 179

Query: 211 ATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPTLNEDEEWKCD 270
           A MEEN Y  FL SDIYLEY R+G E+    S+             YLPTLNE+EEW C 
Sbjct: 180 AVMEENAYQVFLTSDIYLEYVRSGGENTAYMSN--GGLGSLKVLCGYLPTLNEEEEWTC- 236

Query: 271 QDMDEDDGRDAAPPGRL-PQKLLLETAAPRVSSSRRYSEGREFRYGSWR--EPVNPYYVN 327
                     A    +L P  + L +   R ++S R +E  E  + S++  +PVNPY+V 
Sbjct: 237 ----------ADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSDPVNPYHVG 286

Query: 328 AGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRI--RKQHRREMQESVQVNGR 385
           +GY  APATSANDSE                 VDG+PPYR+  +KQ +REM  SV+ NG+
Sbjct: 287 SGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGVPPYRMGSKKQLQREMHRSVKANGQ 346

Query: 386 VPLPHIPRTYRVPKEVR-VEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXXXXXX 444
           V LPH PRT+R+PKE+  VEP  FA ELI RLE ++                        
Sbjct: 347 VSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEG 406

Query: 445 XXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGR 504
                           AP  H  P   +  G      ++EE+P++ILD+H+ RVL+TPG 
Sbjct: 407 SEQALSSRDG------APVQH--PLALLPSG------SYEEDPQTILDDHLSRVLKTPGC 452

Query: 505 QSPG-----PGHRSPDSGHVAKMPVALGGAASGHGKHVPKS------GAKLDAAGLXXXX 553
           QSPG     P  RSPD  H            S  GK  P +      G            
Sbjct: 453 QSPGVGRYSPRSRSPDHHHQHHHHQQCHTLLSTGGKLPPVAACPLLGGKSFLTKQTTKHV 512

Query: 554 XXXXXXXXSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLA 613
                   +  + KE++EAEAT+R +     G + + +        +S   AP    G  
Sbjct: 513 HHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSK-----CKSHPKAPEPLPGEQ 567

Query: 614 HSG-KVGVACKRNAKKAESGKSASTEVPGAS----------EDAEKNQKIMQWIIEGEKE 662
             G + G   KRNAK  E G + S    G S          E+ +++Q + QW++E E++
Sbjct: 568 FCGSRGGTLPKRNAKGTEPGLALSARDGGMSSAAGGPQLPGEEGDRSQDVWQWMLESERQ 627

Query: 663 ISRHRRTGHGTRSQRKVGGGSAQPCDSI 690
                 +    R    +    A P + +
Sbjct: 628 SKSKPHSAQSIRKSYPLESARAAPGERV 655



 Score =  124 bits (310), Expect = 1e-27
 Identities = 94/291 (32%), Positives = 130/291 (44%), Gaps = 50/291 (17%)

Query: 521 KMPVALGGA--ASGHGKHVPKSGAKLDAAGLXXXXXXXXXXXXSTARPKEQVEAEATRRA 578
           K P  L G       G  +PK  AK    GL            S+A    Q+  E   R+
Sbjct: 558 KAPEPLPGEQFCGSRGGTLPKRNAKGTEPGLALSARDGGM---SSAAGGPQLPGEEGDRS 614

Query: 579 QSSFAWGLE--------PHSHGARSRGYS-ESVGAAP---------------NASDGLAH 614
           Q  + W LE        PHS  +  + Y  ES  AAP               + S   AH
Sbjct: 615 QDVWQWMLESERQSKSKPHSAQSIRKSYPLESARAAPGERVSRHHLLGASGHSRSVARAH 674

Query: 615 S----------------GKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIE 658
                             ++  AC+R    AE  K        AS+  ++N         
Sbjct: 675 PFTQDPAMPPLTPPNTLAQLEEACRR---LAEVSKPQKQRCCVASQQRDRNHSAAGQA-- 729

Query: 659 GEKEISRHRRTGHGTRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFK 718
           G    +         +  +K+    A     +VV Y+FCGE IPYR +++ +++TLG FK
Sbjct: 730 GASPFANPSLAPEDHKEPKKLASVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFK 789

Query: 719 ELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           E L+KKG+YRYYFKK SDEF CG VFEE+ +DE VLP++E +I+GKVE++D
Sbjct: 790 EQLSKKGNYRYYFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID 840



>gi|10719896|sp|O70240|AXN2_RAT   Axin 2 (Axis inhibition protein 2) (Conductin) (Axin-like protein)
           (Axil)
          Length = 838

 Score =  376 bits (965), Expect = e-103
 Identities = 262/675 (38%), Positives = 344/675 (50%), Gaps = 75/675 (11%)

Query: 31  DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGY 90
           D  +SF EDAPRPPVPGEEGE     P         GK    K    ++  RR++  LG 
Sbjct: 12  DPSSSFREDAPRPPVPGEEGETPPCQPSV-------GKVQSTKPMPVSSNARRNEDGLG- 63

Query: 91  EPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPC 150
           EPEG ASP  P  +W +SLHSLL DQDG  LFRTFL++E C D LDFWFAC GFR++   
Sbjct: 64  EPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLK 123

Query: 151 DSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQ 210
           D+   K L++A+AIY++YI +NN +VS+Q KPATK++I+  I KQ I   MFDQAQTEIQ
Sbjct: 124 DT---KTLRVAKAIYKRYI-ENNSVVSKQLKPATKTYIRDGIKKQQIGSVMFDQAQTEIQ 179

Query: 211 ATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPTLNEDEEWKCD 270
           A MEEN Y  FL SDIYLEY R+G E+    S+             YLPTLNE+EEW C 
Sbjct: 180 AVMEENAYQVFLTSDIYLEYVRSGGENTAYMSN--GGLGSLKVLCGYLPTLNEEEEWTC- 236

Query: 271 QDMDEDDGRDAAPPGRL-PQKLLLETAAPRVSSSRRYSEGREFRYGSWR--EPVNPYYVN 327
                     A    +L P  + L +   R ++S R +E  E  + S++  EPVNPY+V 
Sbjct: 237 ----------ADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKRSEPVNPYHVG 286

Query: 328 AGYALAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRI--RKQHRREMQESVQVNGR 385
           +GY  APATSANDSE                 VDGIPPYR+  +KQ +REM  SV+ NG+
Sbjct: 287 SGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGIPPYRMGSKKQLQREMHRSVKANGQ 346

Query: 386 VPLPHIPRTYRVPKEVR-VEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXXXXXX 444
           V LPH PRT+R+PKE+  VEP  FA ELI RLE ++                        
Sbjct: 347 VSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLEERLQQIREDEEKEG 406

Query: 445 XXXXXXXXXXCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGR 504
                           AP  H  P   +  G      ++EE+P++ILD+H+ RVL+TPG 
Sbjct: 407 SEQALSSRDG------APVQH--PLALLPSG------SYEEDPQTILDDHLSRVLKTPGC 452

Query: 505 QSPG-----PGHRSPDSGH------VAKMPVALGGAASGHGKHVPKSGAKLDAAGLXXXX 553
           QSPG     P  RSPD  H       A +P   GG            G            
Sbjct: 453 QSPGVGRYSPRSRSPDHHHHHHQQCHALLPT--GGKLPPEAACPLLGGKSFLTKQTTKHV 510

Query: 554 XXXXXXXXSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLA 613
                   +  + KE++EAEAT+R +     G + + +   S+  S S    P   +   
Sbjct: 511 HHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCY---SKCKSHSKPPEPLPGEQFC 567

Query: 614 HSGKVGVACKRNAKKAESGKSASTEVPGAS----------EDAEKNQKIMQWIIEGEKEI 663
            S + G   KRN K  E G +      G S          E+ +++Q + QW++E E++ 
Sbjct: 568 GS-RGGTLPKRNTKGTEPGLALPAREGGMSSAAGAPQLPGEEGDRSQDVWQWMLESERQ- 625

Query: 664 SRHRRTGHGTRSQRK 678
              +   H T+S RK
Sbjct: 626 --SKSKPHSTQSIRK 638



 Score =  121 bits (304), Expect = 6e-27
 Identities = 70/205 (34%), Positives = 103/205 (50%), Gaps = 8/205 (3%)

Query: 566 PKEQVEAEATRRAQSSFAWGLEPHSHGA-RSRGYSESVGAAPNASDGLAHSGKVGVACKR 624
           P E   A    R       G   H   A R+  +++     P          ++  AC+R
Sbjct: 641 PLESARAPPGERVSRHHLLGASGHPRSAARAHPFTQDPAMPPLTPPNTL--AQLEEACRR 698

Query: 625 NAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRKVGGGSA 684
               AE  K        AS+  ++N         G    S         +  +++    A
Sbjct: 699 ---LAEVSKPQKQRCCVASQQRDRNHPATGQA--GPTSFSNPSLASEDHKEPKRLASVHA 753

Query: 685 QPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVF 744
                ++V Y+FCGE IPYR +++ +++TLG FKE L+KKG+YRYYFKK SDEF CG VF
Sbjct: 754 LQASELIVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVF 813

Query: 745 EEVREDEAVLPVFEEKIIGKVEKVD 769
           EE+ +DE VLP++E +I+GKVE++D
Sbjct: 814 EEIWDDETVLPMYEGRILGKVERID 838



>gi|10719905|sp|P57095|AXN2_BRARE   Axin 2 (Axis inhibition protein 2)
          Length = 812

 Score =  351 bits (901), Expect = 4e-96
 Identities = 257/693 (37%), Positives = 343/693 (49%), Gaps = 72/693 (10%)

Query: 34  ASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPE 93
           +SF ED PRPPVPGEEGE     P   +          I  +   +T RR +  LG EPE
Sbjct: 11  SSFREDDPRPPVPGEEGETTCHHPSKLAMMRPKDPVKTIMADLRCSTARRDEDGLG-EPE 69

Query: 94  GSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSN 153
           GSASP  P  +W +SLH LL DQDG  LFR +L++E C D LDFWFAC GFR++   D  
Sbjct: 70  GSASPDSPLARWTKSLHFLLGDQDGAQLFRAYLEREKCVDTLDFWFACNGFRQM---DLK 126

Query: 154 EEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATM 213
           + K  ++A+AIY++YI +NN IV++Q KPATK+FI+  I +Q ID AMFDQAQ EIQ  M
Sbjct: 127 DTKTHRVAKAIYKRYI-ENNSIVAKQLKPATKTFIRDNIKRQQIDSAMFDQAQMEIQTAM 185

Query: 214 EENTYPSFLKSDIYLEYTRTGSESPKVCSDQXXXXXXXXXXXXYLPTLNEDEEWKCDQDM 273
           EEN Y  FL SDIYLEY RTG E+P   +              YLPTLNE+EEW C    
Sbjct: 186 EENAYQMFLTSDIYLEYVRTGCENPSHVNPN--GLGGLKLVCGYLPTLNEEEEWSC---- 239

Query: 274 DEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWR--EPVNPYYVNAGYA 331
           ++   +  A    L  K L        S   R  E  E  Y S+R  +P NP    +GY+
Sbjct: 240 NDFKAKALATVVGLSAKTLR-------SPPLRAVEALEKGYRSYRRSDPGNPNRFTSGYS 292

Query: 332 LAPATSANDSEQQXXXXXXXXXXXXXXXVDGIPPYRI--RKQHRREMQESVQVNGRVPLP 389
            APATSANDSE                 VD IPPY++  +KQ +REMQ ++++NG+V LP
Sbjct: 293 FAPATSANDSEVSSDALTDDSMSMTDSSVDAIPPYKLGSKKQLQREMQRNMRMNGQVSLP 352

Query: 390 HIPRTYRVPKEVR-VEPQKFAEELIHRLEAVQXXXXXXXXXXXXXXXXXXXXXXXXXXXX 448
             PRT R PKE+  VEP  FA +LI RLE ++                            
Sbjct: 353 PFPRTRRPPKEMTPVEPAAFAAQLIARLERLKREQETMSSLEERLQQIQEEEERDESEMS 412

Query: 449 XXXXXXCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGRQSPG 508
                  H LP  P     P  C            EE+P++ILDEH+ RVL+TPG QSPG
Sbjct: 413 SSSAS--HSLPLLP-----PGTC------------EEDPQAILDEHLSRVLKTPGCQSPG 453

Query: 509 PGHRSPDSGHVAKMPVALGG-----AASGHGKHVPKSGAKLDAAGLXXXXXXXXXXXXST 563
               SP S    + P+  GG      +S    +VP       +               + 
Sbjct: 454 LLRHSPRSRSPEQRPLPRGGLSTRSQSSSMNGYVP--AKTFISRQSTKHIHHHYIHHHAG 511

Query: 564 ARPKEQVEAEATRRAQSSFAWGLE----PHSHGARSRGYSESVGAAPNASDGLAHSGKVG 619
            + KEQ+E EAT+R Q       E    P+    RSR       A+P A   L HS  + 
Sbjct: 512 PKSKEQIEVEATQRVQCLCHGTSECCTAPY---IRSRSLGRDQCASP-AEVALGHSSTLS 567

Query: 620 V-ACKRNAK-KAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHR-------RTG 670
              CK   +   E  +++  ++P  S D  ++Q + QWI+E +++ ++H+       +  
Sbjct: 568 KRLCKSGEEVNMEGLENSLLQLPADSTD--RSQNVWQWILESDRQ-TKHKPHSTQNVKKS 624

Query: 671 HG---TRSQRKVGGGSAQPCDSIVVAYYFCGEP 700
           H    TR+    GGGS+    +   A+ F  +P
Sbjct: 625 HSLEPTRTHTWGGGGSSGHLRAHQPAHPFVQDP 657



 Score =  113 bits (282), Expect = 2e-24
 Identities = 84/275 (30%), Positives = 127/275 (46%), Gaps = 56/275 (20%)

Query: 528 GAASGHGKHVPKSGAKLDAAGLXXXXXXXXXXXXSTARPKEQVEAEATRRAQSSFAWGLE 587
           G +S   K + KSG +++  GL                   Q+ A++T R+Q+ + W LE
Sbjct: 561 GHSSTLSKRLCKSGEEVNMEGLENSLL--------------QLPADSTDRSQNVWQWILE 606

Query: 588 --------PHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEV 639
                   PHS    ++   +S    P  +      G  G               A   +
Sbjct: 607 SDRQTKHKPHS----TQNVKKSHSLEPTRTHTWGGGGSSGHLRAHQPAHPFVQDPAMPPL 662

Query: 640 PGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRK--------VGGGSAQPCDS-- 689
           P  +  A+  +   +      +E+S+  +  H T S ++          G SA P D   
Sbjct: 663 PPPNTLAQLEEARRRL-----EEVSKPSKQRHSTSSLQRDKSHPVPVQNGSSAFPMDERK 717

Query: 690 ---------------IVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKV 734
                           VV Y+FCGE IPYR +++  ++TLG FKE L KKG+YRY+FK+ 
Sbjct: 718 DPKKMSGCHSSLGSETVVTYFFCGEEIPYRRMMKTHSLTLGHFKEQLRKKGNYRYFFKRA 777

Query: 735 SDEFDCGVVFEEVREDEAVLPVFEEKIIGKVEKVD 769
           SDEF+CG VFEEV +D  VLP++E KI+GKV+++D
Sbjct: 778 SDEFECGAVFEEVWDDCTVLPMYEGKILGKVDRMD 812



>gi|12643522|sp|Q9V407|AXN_DROME   Axin (Axis inhibition protein) (dAxin) (d-Axin)
          Length = 745

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 57/204 (27%), Positives = 100/204 (49%), Gaps = 41/204 (20%)

Query: 41  PRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTP 100
           PRPPVPGEE  +               +GV                      + S + +P
Sbjct: 19  PRPPVPGEESRVKKMT-----------EGVA---------------------DTSKNSSP 46

Query: 101 PYLKWAESLHSLLDDQDGISLFRTFLKQEGCA--DLLDFWFACTGFRKLEPCDSNEEKRL 158
            YL WA +L+ LL+D+DG+ LF+ ++++E  A  D L+F+FAC G ++     ++ EK  
Sbjct: 47  SYLNWARTLNHLLEDRDGVELFKKYVEEEAPAYNDHLNFYFACEGLKQ----QTDPEKIK 102

Query: 159 KLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTY 218
           ++  AIYR ++  +   +S   +   K+      +   + P +FD  Q  ++ T+ +N Y
Sbjct: 103 QIIGAIYR-FLRKSQLSISDDLRAQIKAIKTNPEIP--LSPHIFDPMQRHVEVTIRDNIY 159

Query: 219 PSFLKSDIYLEYTRTGSESPKVCS 242
           P+FL S++Y+ Y +  S   + C+
Sbjct: 160 PTFLCSEMYILYIQQMSAQQERCT 183



 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 35/86 (40%), Positives = 56/86 (65%), Gaps = 1/86 (1%)

Query: 684 AQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVV 743
           A+P ++IVV + FC EP+PYR  + G   TL QFK+ L ++G +R++FK   ++ D  V+
Sbjct: 661 AKPPETIVV-FSFCEEPVPYRIKIPGTQPTLRQFKDYLPRRGHFRFFFKTHCEDPDSPVI 719

Query: 744 FEEVREDEAVLPVFEEKIIGKVEKVD 769
            EE+  D  +LP+F +K +G V+  D
Sbjct: 720 QEEIVNDSDILPLFGDKAMGLVKPSD 745



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 12/67 (17%)

Query: 484 EENPESILDEHVQRVL------RTPGRQSPGPGHRS------PDSGHVAKMPVALGGAAS 531
           E+N + ILD+HV RV       R+PG  SP P   S       DSG V+   ++L G + 
Sbjct: 494 EDNDQDILDQHVSRVWKDQTPHRSPGTMSPCPPIPSRRRTATHDSGMVSDGAMSLSGHSM 553

Query: 532 GHGKHVP 538
            H K +P
Sbjct: 554 KHSKSMP 560



>gi|1710136|sp|P49796|RGS3_HUMAN   Regulator of G-protein signaling 3 (RGS3) (RGP3)
          Length = 519

 Score = 79.3 bits (194), Expect = 4e-14
 Identities = 55/172 (31%), Positives = 83/172 (48%), Gaps = 29/172 (16%)

Query: 82  RRSDLDLGYEPEGSAS-------PTPPY-LKWAESLHSLLDDQDGISLFRTFLKQEGCAD 133
           RR +   G  P G A        PT    LKW ESL  LL  + G+++F+ FL+ E   +
Sbjct: 360 RRRNESPGAPPAGKADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEE 419

Query: 134 LLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYI-------LDNNGIVSRQTKPATKS 186
            L+FW AC  F+K++    ++ K    A+ I+ +YI       ++ +      TK   +S
Sbjct: 420 NLEFWLACEDFKKVK----SQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQS 475

Query: 187 FIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESP 238
             +GC          FD AQ  I   ME+++YP FL+SD+YL+       SP
Sbjct: 476 VTRGC----------FDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSP 517



>gi|18266777|sp|O43665|RGSA_HUMAN   Regulator of G-protein signaling 10 (RGS10)
          Length = 173

 Score = 78.6 bits (192), Expect = 6e-14
 Identities = 50/151 (33%), Positives = 84/151 (55%), Gaps = 12/151 (7%)

Query: 90  YEPEGSASPTPPYLK----WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFR 145
           ++ +GS+S +   LK    WA SL +LL+D +G+  FR FLK+E   + + FW AC  F+
Sbjct: 11  HDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFK 70

Query: 146 KLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQA 205
           K++     +EK    A+ IY  ++   +   S Q     +S +   I+++   P MF + 
Sbjct: 71  KMQDKTQMQEK----AKEIYMTFL---SSKASSQVNVEGQSRLNEKILEE-PHPLMFQKL 122

Query: 206 QTEIQATMEENTYPSFLKSDIYLEYTRTGSE 236
           Q +I   M+ ++Y  FLKSD++L++ RT  E
Sbjct: 123 QDQIFNLMKYDSYSRFLKSDLFLKHKRTEEE 153



>gi|15214217|sp|Q9DC04|RGS3_MOUSE   Regulator of G-protein signaling 3 (RGS3)
          Length = 568

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 46/143 (32%), Positives = 74/143 (51%), Gaps = 21/143 (14%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           LKW+ESL  LL  + G+ +F+ FL+ E   + L+FW AC  F+K++    ++ K    A+
Sbjct: 438 LKWSESLEKLLLHKYGLEVFQAFLRTEFSEENLEFWLACEDFKKVK----SQSKMAAKAK 493

Query: 163 AIYRKYI-------LDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEE 215
            I+ ++I       ++ +      TK   +S  +GC          FD AQ  I   ME+
Sbjct: 494 KIFAEFIAIQACKEVNLDSYTREHTKENLQSITRGC----------FDLAQKRIFGLMEK 543

Query: 216 NTYPSFLKSDIYLEYTRTGSESP 238
           ++YP FL+SD+YL+       SP
Sbjct: 544 DSYPRFLRSDLYLDLINQKKMSP 566



>gi|15214211|sp|Q99PG4|RGSI_MOUSE   Regulator of G-protein signaling 18 (RGS18)
          Length = 235

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 49/139 (35%), Positives = 70/139 (50%), Gaps = 13/139 (9%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           +KWAES   LL  +DG+  F  FLK E   + ++FW AC  F+K   C   ++  LK A+
Sbjct: 81  VKWAESFDKLLSHRDGVDAFTRFLKTEFSEENIEFWVACEDFKK---CKEPQQIILK-AK 136

Query: 163 AIYRKYILDNNGIVSRQTKPATKSF-IKGCIMKQLIDPAM--FDQAQTEIQATMEENTYP 219
           AIY K+I ++        K     F  K  I K +  P +  FD AQ+ +   ME ++Y 
Sbjct: 137 AIYEKFIQND------APKEVNIDFHTKEVIAKSIAQPTLHSFDTAQSRVYQLMEHDSYK 190

Query: 220 SFLKSDIYLEYTRTGSESP 238
            FLKS+ YL       + P
Sbjct: 191 RFLKSETYLHLIEGRPQRP 209



>gi|15214214|sp|Q9CQE5|RGSA_MOUSE   Regulator of G-protein signaling 10 (RGS10)
          Length = 181

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 47/133 (35%), Positives = 73/133 (54%), Gaps = 8/133 (6%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           KWA SL +LL+D +G+  FR FLK+E   + + FW AC  F+K E     +EK    A+ 
Sbjct: 37  KWASSLENLLEDPEGVQRFREFLKKEFSEENVLFWLACEDFKKTEDRKQMQEK----AKE 92

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLK 223
           IY  ++ +     S Q     +S +   I+++   P MF + Q +I   M+ ++Y  FLK
Sbjct: 93  IYMTFLSNK---ASSQVNVEGQSRLTEKILEE-PHPLMFQKLQDQIFNLMKYDSYSRFLK 148

Query: 224 SDIYLEYTRTGSE 236
           SD++L+  RT  E
Sbjct: 149 SDLFLKPKRTEEE 161



>gi|3914625|sp|O15539|RGS5_HUMAN   Regulator of G-protein signaling 5 (RGS5)
          Length = 181

 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 42/129 (32%), Positives = 71/129 (55%), Gaps = 11/129 (8%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           L+W +SL  LL +  G++ F++FLK E   + L+FW AC  ++K++    +  K  + A+
Sbjct: 59  LQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIK----SPAKMAEKAK 114

Query: 163 AIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPS 220
            IY ++I           +     F K   MK L++P++  FD AQ  I A ME+++ P 
Sbjct: 115 QIYEEFIQ-----TEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPR 169

Query: 221 FLKSDIYLE 229
           F++S+ Y E
Sbjct: 170 FVRSEFYQE 178



>gi|15214228|sp|Q9NS28|RGSI_HUMAN   Regulator of G-protein signaling 18 (RGS18)
          Length = 235

 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 48/139 (34%), Positives = 70/139 (50%), Gaps = 13/139 (9%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           +KW ES   LL  +DG+  F  FLK E   + ++FW AC  F+K +     ++  LK A+
Sbjct: 81  VKWGESFDKLLSHRDGLEAFTRFLKTEFSEENIEFWIACEDFKKSK---GPQQIHLK-AK 136

Query: 163 AIYRKYILDNNGIVSRQTKPATKSF-IKGCIMKQLIDPAM--FDQAQTEIQATMEENTYP 219
           AIY K+I  +        K     F  K  I   +  P +  FD AQ+ +   ME+++Y 
Sbjct: 137 AIYEKFIQTD------APKEVNLDFHTKEVITNSITQPTLHSFDAAQSRVYQLMEQDSYT 190

Query: 220 SFLKSDIYLEYTRTGSESP 238
            FLKSDIYL+      + P
Sbjct: 191 RFLKSDIYLDLMEGRPQRP 209



>gi|19862758|sp|Q08116|RGS1_HUMAN   Regulator of G-protein signaling 1 (RGS1) (Early response protein
           1R20) (B-cell activation protein BL34)
          Length = 196

 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 45/133 (33%), Positives = 71/133 (53%), Gaps = 22/133 (16%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLE----PCDSNEEKRL 158
           ++W++SL  LL +Q G ++F +FLK E   + ++FW AC  ++K E    PC + E    
Sbjct: 67  MQWSQSLEKLLANQTGQNVFGSFLKSEFSEENIEFWLACEDYKKTESDLLPCKAEE---- 122

Query: 159 KLARAIYRKYILDNNG---IVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEE 215
                IY+ ++  +      +  +T+ +T   IK         P  FD+AQ  I   ME+
Sbjct: 123 -----IYKAFVHSDAAKQINIDFRTRESTAKKIKA------PTPTCFDEAQKVIYTLMEK 171

Query: 216 NTYPSFLKSDIYL 228
           ++YP FLKSDIYL
Sbjct: 172 DSYPRFLKSDIYL 184



>gi|19855046|sp|O08850|RGS5_MOUSE   Regulator of G-protein signaling 5 (RGS5)
          Length = 181

 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 50/153 (32%), Positives = 77/153 (50%), Gaps = 17/153 (11%)

Query: 85  DLDLGY--EPEGSASPTPP----YLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFW 138
           DL + Y  +PE  A    P     L+W +SL  LL +  G + F++FLK E   + L+FW
Sbjct: 35  DLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQNSYGFASFKSFLKSEFSEENLEFW 94

Query: 139 FACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLID 198
            AC  ++K++      EK    A+ IY ++I           +     F K   MK L++
Sbjct: 95  VACENYKKIKSPIKMAEK----AKQIYEEFIQ-----TEAPKEVNIDHFTKDITMKNLVE 145

Query: 199 PA--MFDQAQTEIQATMEENTYPSFLKSDIYLE 229
           P+   FD AQ  I A ME+++ P F++S+ Y E
Sbjct: 146 PSPRSFDLAQKRIYALMEKDSLPRFVRSEFYKE 178



>gi|13124465|sp|P57771|RGS8_HUMAN   Regulator of G-protein signaling 8 (RGS8)
          Length = 180

 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 43/131 (32%), Positives = 72/131 (54%), Gaps = 17/131 (12%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +WA+S   LL  + G++ FR FLK E   + L+FW AC  F+K      +  K +  A  
Sbjct: 52  RWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTR----STAKLVSKAHR 107

Query: 164 IYRKYI---LDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTY 218
           I+ +++         +  QT+ AT+        K L +P++  FDQAQ ++ + ME+++Y
Sbjct: 108 IFEEFVDVQAPREVNIDFQTREATR--------KNLQEPSLTCFDQAQGKVHSLMEKDSY 159

Query: 219 PSFLKSDIYLE 229
           P FL+S +YL+
Sbjct: 160 PRFLRSKMYLD 170



>gi|51701807|sp|Q8BXT1|RGS8_MOUSE   Regulator of G-protein signaling 8 (RGS8)
          Length = 180

 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 43/131 (32%), Positives = 72/131 (54%), Gaps = 17/131 (12%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +WAES   LL  + G++ FR FLK E   + L+FW AC  F+K      +  K +  A  
Sbjct: 52  RWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTR----STAKLVTKAHR 107

Query: 164 IYRKYI---LDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTY 218
           I+ +++         +  QT+ AT+        K + +P++  FDQAQ ++ + ME+++Y
Sbjct: 108 IFEEFVDVQAPREVNIDFQTREATR--------KNMQEPSLTCFDQAQGKVHSLMEKDSY 159

Query: 219 PSFLKSDIYLE 229
           P FL+S +YL+
Sbjct: 160 PRFLRSKMYLD 170



>gi|13124774|sp|P49800|RGS5_RAT   Regulator of G-protein signaling 5 (RGS5)
          Length = 181

 Score = 72.0 bits (175), Expect = 6e-12
 Identities = 50/153 (32%), Positives = 76/153 (49%), Gaps = 17/153 (11%)

Query: 85  DLDLGY--EPEGSASPTPP----YLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFW 138
           DL + Y  +PE  A    P     L+W +SL  LL    G + F++FLK E   + L+FW
Sbjct: 35  DLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQSNYGFASFKSFLKSEFSEENLEFW 94

Query: 139 FACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLID 198
            AC  ++K++      EK    A+ IY ++I           +     F K   MK L++
Sbjct: 95  VACENYKKIKSPIKMAEK----AKQIYEEFIQ-----TEAPKEVNIDHFTKDITMKNLVE 145

Query: 199 PA--MFDQAQTEIQATMEENTYPSFLKSDIYLE 229
           P+   FD AQ  I A ME+++ P F++S+ Y E
Sbjct: 146 PSPHSFDLAQKRIYALMEKDSLPRFVRSEFYKE 178



>gi|1710149|sp|P49799|RGS4_RAT   Regulator of G-protein signaling 4 (RGS4) (RGP4)
          Length = 205

 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 42/134 (31%), Positives = 73/134 (54%), Gaps = 11/134 (8%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           KWAESL +L++ + G++ F+ FLK E   + +DFW +C  ++K++    +  K    A+ 
Sbjct: 58  KWAESLENLINHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIK----SPSKLSPKAKK 113

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSF 221
           IY ++I      V    +    S  +    + +++P +  FD+AQ +I   ME+++Y  F
Sbjct: 114 IYNEFI-----SVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRF 168

Query: 222 LKSDIYLEYTRTGS 235
           LKS  YL+ T   S
Sbjct: 169 LKSRFYLDLTNPSS 182



>gi|6093964|sp|P49804|RGS8_RAT   Regulator of G-protein signaling 8 (RGS8)
          Length = 180

 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 42/131 (32%), Positives = 72/131 (54%), Gaps = 17/131 (12%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +WA+S   LL  + G++ FR FLK E   + L+FW AC  F+K      +  K +  A  
Sbjct: 52  RWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTR----STAKLVTKAHR 107

Query: 164 IYRKYI---LDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTY 218
           I+ +++         +  QT+ AT+        K + +P++  FDQAQ ++ + ME+++Y
Sbjct: 108 IFEEFVDVQAPREVNIDFQTREATR--------KNMQEPSLTCFDQAQGKVHSLMEKDSY 159

Query: 219 PSFLKSDIYLE 229
           P FL+S +YL+
Sbjct: 160 PRFLRSKMYLD 170



>gi|15214234|sp|Q9QZB0|RGSH_MOUSE   Regulator of G-protein signaling 17 (RGS17) (Regulator of
           Gz-selective protein signaling 2)
          Length = 210

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 51/175 (29%), Positives = 88/175 (50%), Gaps = 16/175 (9%)

Query: 73  KGETSTATPRRSDLDLGYEPEGSASPTPP-YLKWAESLHSLLDDQDGISLFRTFLKQEGC 131
           +G++S  +P  + ++     E   +PT    L W+++   ++    G +LFR FL+ E  
Sbjct: 48  RGDSSGRSPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKTPAGRNLFREFLRTEYS 107

Query: 132 ADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGC 191
            + L FW AC   +K +   + EEK    AR IY  YI     I+S + + +  S ++  
Sbjct: 108 EENLLFWLACEDLKKEQNKKAVEEK----ARMIYEDYI----SILSPK-EVSLDSRVREV 158

Query: 192 IMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQ 244
           I + L+DP+  M++ AQ +I   M  +++P FL S IY  +     ES   C+ +
Sbjct: 159 INRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFV----ESTTSCTSE 209



>gi|14916689|sp|Q9JHX0|RGS2_RAT   Regulator of G-protein signaling 2 (RGS2)
          Length = 211

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 47/155 (30%), Positives = 73/155 (47%), Gaps = 14/155 (9%)

Query: 77  STATPRRSDLDLGYEPEGSASPTPPY-LKWAESLHSLLDDQDGISLFRTFLKQEGCADLL 135
           +++TP +       + +    P+P   L WAE+   LL  + G++ FR FLK E C + +
Sbjct: 51  NSSTPGKPKTGKKSKQQTFIKPSPEEALLWAEAFDELLASKYGLAAFRAFLKSEFCEENI 110

Query: 136 DFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQ 195
           +FW AC  F+K +    + +K    AR IY  +      I     K     F    ++ Q
Sbjct: 111 EFWLACEDFKKTK----SPQKLSSKARKIYTDF------IEKEAPKEINIDFQTKTLIAQ 160

Query: 196 LIDPA---MFDQAQTEIQATMEENTYPSFLKSDIY 227
            I  A    F  AQ  + + ME N+YP FL+S+ Y
Sbjct: 161 NIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFY 195



>gi|6093966|sp|P56700|RGSG_RAT   Regulator of G-protein signaling 16 (RGS16) (Retinally abundant
           regulator of G-protein signaling) (RGS-R)
          Length = 199

 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 48/166 (28%), Positives = 76/166 (45%), Gaps = 13/166 (7%)

Query: 73  KGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCA 132
           K E S+ T      +   +     S +   L W ES  SLL+ ++G++ F  FLK E   
Sbjct: 29  KSELSSDTGGNGKFEWASKLSKERSFSEDVLGWRESFQSLLNSKNGVAAFHAFLKTEFSE 88

Query: 133 DLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYI---LDNNGIVSRQTKPATKSFIK 189
           + L+FW AC  F+K+     +  K    A  I+ +YI         +  +T+  TK+ + 
Sbjct: 89  ENLEFWLACEEFKKIR----SATKLASRAHHIFDEYIRSEAPKEVNIDHETRELTKTNL- 143

Query: 190 GCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGS 235
                Q    + FD AQ + +  ME+++YP FLKS  Y +     S
Sbjct: 144 -----QAATTSCFDVAQGKTRTLMEKDSYPRFLKSPAYRDLAAQAS 184



>gi|2500167|sp|O08899|RGS4_MOUSE   Regulator of G-protein signaling 4 (RGS4)
          Length = 205

 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 42/134 (31%), Positives = 70/134 (52%), Gaps = 11/134 (8%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           KWAESL +L+  + G++ F+ FLK E   + +DFW +C  ++K++    +  K    A+ 
Sbjct: 58  KWAESLENLIHHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIK----SPSKLSPKAKK 113

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSF 221
           IY ++I      V    +    S  +    + ++ P +  FD+AQ +I   ME ++Y  F
Sbjct: 114 IYNEFI-----SVQATKEVNLDSCTREETSRNMLQPTITCFDEAQKKIFNLMERDSYRRF 168

Query: 222 LKSDIYLEYTRTGS 235
           LKS  YL+ T   S
Sbjct: 169 LKSRFYLDLTNPSS 182



>gi|19855045|sp|O08849|RGS2_MOUSE   Regulator of G-protein signaling 2 (RGS2)
          Length = 211

 Score = 68.6 bits (166), Expect = 6e-11
 Identities = 43/123 (34%), Positives = 61/123 (49%), Gaps = 7/123 (5%)

Query: 105 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAI 164
           WAE+   LL  + G++ FR FLK E C + ++FW AC  F+K +    + +K    AR I
Sbjct: 80  WAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTK----SPQKLSSKARKI 135

Query: 165 YRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKS 224
           Y  +I +            TKS I   I  Q      F  AQ  + + ME N+YP FL+S
Sbjct: 136 YTDFI-EKEAPKEINIDFQTKSLIAQNI--QEATSGCFTTAQKRVYSLMENNSYPRFLES 192

Query: 225 DIY 227
           + Y
Sbjct: 193 EFY 195



>gi|1710146|sp|P49798|RGS4_HUMAN   Regulator of G-protein signaling 4 (RGS4) (RGP4)
          Length = 205

 Score = 68.6 bits (166), Expect = 6e-11
 Identities = 41/134 (30%), Positives = 71/134 (52%), Gaps = 11/134 (8%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           KWAESL +L+  + G++ F+ FLK E   + +DFW +C  ++K++    +  K    A+ 
Sbjct: 58  KWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIK----SPSKLSPKAKK 113

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSF 221
           IY ++I      V    +    S  +    + +++P +  FD+AQ +I   ME+++Y  F
Sbjct: 114 IYNEFI-----SVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRF 168

Query: 222 LKSDIYLEYTRTGS 235
           LKS  YL+     S
Sbjct: 169 LKSRFYLDLVNPSS 182



>gi|729545|sp|P41220|RGS2_HUMAN   Regulator of G-protein signaling 2 (RGS2) (G0/G1 switch regulatory
           protein 8)
          Length = 211

 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 45/155 (29%), Positives = 73/155 (47%), Gaps = 14/155 (9%)

Query: 77  STATPRRSDLDLGYEPEGSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLL 135
           +++TP +       + +    P+P   + W+E+   LL  + G++ FR FLK E C + +
Sbjct: 51  NSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENI 110

Query: 136 DFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQ 195
           +FW AC  F+K +    + +K    AR IY  +      I     K     F    ++ Q
Sbjct: 111 EFWLACEDFKKTK----SPQKLSSKARKIYTDF------IEKEAPKEINIDFQTKTLIAQ 160

Query: 196 LIDPA---MFDQAQTEIQATMEENTYPSFLKSDIY 227
            I  A    F  AQ  + + ME N+YP FL+S+ Y
Sbjct: 161 NIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFY 195



>gi|15214223|sp|Q9JL25|RGS1_MOUSE   Regulator of G-protein signaling 1 (RGS1)
          Length = 196

 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 43/126 (34%), Positives = 66/126 (52%), Gaps = 8/126 (6%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           ++W++SL  LL +Q G ++F  FLK E   + ++FW AC  ++K E  D    K   + +
Sbjct: 67  MQWSQSLEKLLANQTGQNVFGRFLKSEFSEENIEFWLACEDYKKTE-TDLLHNKAENIYK 125

Query: 163 AIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFL 222
           A      +    I    T+ +T   IK         P  FD+AQ  I + ME+++YP FL
Sbjct: 126 AFVHSDAVKQINI-DFHTRESTAKKIK------TPTPTSFDEAQKVIYSLMEKDSYPRFL 178

Query: 223 KSDIYL 228
           KS+IYL
Sbjct: 179 KSNIYL 184



>gi|2500171|sp|P97428|RGSG_MOUSE   Regulator of G-protein signaling 16 (RGS16) (Retinally abundant
           regulator of G-protein signaling) (RGS-R) (A28-RGS14P)
          Length = 201

 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 48/166 (28%), Positives = 76/166 (45%), Gaps = 13/166 (7%)

Query: 73  KGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCA 132
           K E S+ T   S  +   +     S +   L W ES   LL+ ++G++ F  FLK E   
Sbjct: 29  KSELSSDTGGISKFEWASKHNKERSFSEDVLGWRESFDLLLNSKNGVAAFHAFLKTEFSE 88

Query: 133 DLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYI---LDNNGIVSRQTKPATKSFIK 189
           + L+FW AC  F+K+     +  K    A  I+ +YI         +  +T+  TK+ + 
Sbjct: 89  ENLEFWLACEEFKKIR----SATKLASRAHHIFDEYIRSEAPKEVNIDHETRELTKTNL- 143

Query: 190 GCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGS 235
                Q    + FD AQ + +  ME+++YP FLKS  Y +     S
Sbjct: 144 -----QAATTSCFDVAQGKTRTLMEKDSYPRFLKSPAYRDLAAQAS 184



>gi|3914630|sp|O46471|RGSG_BOVIN   Regulator of G-protein signaling 16 (RGS16) (Retinally abundant
           regulator of G-protein signaling) (RGS-R)
          Length = 202

 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 41/128 (32%), Positives = 64/128 (50%), Gaps = 13/128 (10%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           L W ES   LL  ++G++ F  FLK E   + L+FW AC  F+KL     +  K    A 
Sbjct: 60  LGWKESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKLR----SATKLGSRAH 115

Query: 163 AIYRKYILD---NNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYP 219
            I+ ++I         +  +T+  T++ +      Q      FD AQ +++A ME+++YP
Sbjct: 116 RIFEEFICSEAPKEVNIDHETRELTRTNL------QAATAVCFDAAQWKVRALMEKDSYP 169

Query: 220 SFLKSDIY 227
            FLKS  Y
Sbjct: 170 RFLKSPAY 177



>gi|15214232|sp|Q9PWA0|RGSH_CHICK   Regulator of G-protein signaling 17 (RGS17)
          Length = 210

 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 48/139 (34%), Positives = 73/139 (52%), Gaps = 13/139 (9%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           L WA++   ++    G +LFR FL+ E   + L FW AC   +K +     EEK    AR
Sbjct: 79  LSWAQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEK----AR 134

Query: 163 AIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPS 220
            IY  YI     I+S + + +  S ++  I + L+DP+  M++ AQ +I   M  +++P 
Sbjct: 135 LIYEDYI----SILSPK-EVSLDSRVREVINRNLLDPSPHMYEDAQLQIYTLMHRDSFPR 189

Query: 221 FLKSDIY--LEYTRTGSES 237
           FL S IY  L  + TGS S
Sbjct: 190 FLNSQIYKSLVESITGSTS 208



>gi|15214235|sp|Q9QZB1|RGSK_MOUSE   Regulator of G-protein signaling 20 (RGS20) (Regulator of G-protein
           signaling Z1)
          Length = 239

 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 62/227 (27%), Positives = 99/227 (43%), Gaps = 25/227 (11%)

Query: 15  ARQSPKMNIQEQGFPLDLGASFTEDAPRP---------PVPGEEGELVSTDPRPASYSFC 65
           AR SP  +  + G P   G+  TE   R          P P ++G   S          C
Sbjct: 10  ARASPSASPADPGLPE--GSERTEMRMRQMCGGSETQGPAPSQQGGRGSNACCFCWCCCC 67

Query: 66  SGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLK---WAESLHSLLDDQDGISLF 122
           +   + ++ +      R S       P    SPTP   +   WA+S  +L+    G + F
Sbjct: 68  TCSCLTVRNQEDQRPQRASHEIRTDIPACEESPTPTLEEVCAWAQSFDNLMVTPAGRNAF 127

Query: 123 RTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKP 182
           R FL+ E   + + FW AC   ++     + EEK    AR IY  YI     I+S + + 
Sbjct: 128 REFLRTEFSEENMLFWMACEELKREANKSTIEEK----ARIIYEDYI----SILSPK-EV 178

Query: 183 ATKSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIY 227
           +  S ++  I + ++DP+  +FD AQ +I   M  ++YP F+ S +Y
Sbjct: 179 SLDSRVREVINRNMVDPSQHIFDDAQLQIYTLMHRDSYPRFMNSTVY 225



>gi|41017772|sp|Q8WQC0|RGS7_CAEEL   Regulator of G-protein signaling rgs-7 (Regulator of G-protein
           signaling c2) (Protein C2-RGS)
          Length = 819

 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 41/151 (27%), Positives = 77/151 (50%), Gaps = 13/151 (8%)

Query: 83  RSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACT 142
           RS +DL               +W  S  SLL+++ G +LFR FLK+E   + +DFW  C 
Sbjct: 657 RSKMDLALSTSSLYPSRDDVRQWEISFESLLNNKFGCALFRQFLKKEFSDENMDFWLECE 716

Query: 143 GFRKLEPCDSNEEKRLKLARAIYRKYILDNNG---IVSRQTKPATKSFIK-GCIMKQLID 198
            F+K++     ++   + A  IY +++ +++     +   T+ ATK+ ++ GC       
Sbjct: 717 EFKKMK---DGKKSTTQKAIEIYSEFVAEHSPKEVNLDSDTRAATKAAVEAGC------K 767

Query: 199 PAMFDQAQTEIQATMEENTYPSFLKSDIYLE 229
           P  F  AQ+ ++  M +++Y  FL+  ++L+
Sbjct: 768 PDTFALAQSRVEQLMSKDSYRRFLRDRLFLD 798



>gi|51701812|sp|Q8K443|RGS13_MOUSE   Regulator of G-protein signaling 13 (RGS13)
          Length = 158

 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 39/133 (29%), Positives = 70/133 (52%), Gaps = 11/133 (8%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           LKWA+SL SL+  + G  ++  +LK E   + + FW AC  ++K+    ++   R+  A+
Sbjct: 29  LKWAQSLESLMATKYGPIVYTAYLKLEHSDENIKFWMACETYKKI----ASRRGRISRAK 84

Query: 163 AIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPS 220
            +Y  YI   +       +    S  +  I+K + +P    F++AQ  +   ME ++YP 
Sbjct: 85  KLYNIYIQPQS-----PREINIDSTTREAIIKSIREPTQTCFEEAQKIVYMHMEMDSYPR 139

Query: 221 FLKSDIYLEYTRT 233
           FLKS++Y +  +T
Sbjct: 140 FLKSEMYQQLLKT 152



>gi|3914624|sp|O15492|RGS16_HUMAN   Regulator of G-protein signaling 16 (RGS16) (Retinally abundant
           regulator of G-protein signaling) (RGS-R) (A28-RGS14P)
          Length = 202

 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 13/143 (9%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           L W ES   LL  ++G++ F  FLK E   + L+FW AC  F+K+     +  K    A 
Sbjct: 60  LGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIR----SATKLASRAH 115

Query: 163 AIYRKYILD---NNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYP 219
            I+ ++I         +  +T+  T+  +      Q      FD AQ + +  ME+++YP
Sbjct: 116 QIFEEFICSEAPKEVNIDHETRELTRMNL------QTATATCFDAAQGKTRTLMEKDSYP 169

Query: 220 SFLKSDIYLEYTRTGSESPKVCS 242
            FLKS  Y +     S +    S
Sbjct: 170 RFLKSPAYRDLAAQASAASATLS 192



>gi|15214233|sp|Q9PWA1|RGSK_CHICK   Regulator of G-protein signaling 20 (RGS20) (Gz-GAP)
          Length = 218

 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 50/162 (30%), Positives = 81/162 (50%), Gaps = 16/162 (9%)

Query: 82  RRSDLDLGYE--PEGSASPTPPYLK---WAESLHSLLDDQDGISLFRTFLKQEGCADLLD 136
           RR+  +L  E  P    SP P   +   WA+S   L+    G + FR FL+ E   + + 
Sbjct: 61  RRTSHELQAEGIPNCEESPAPTLEEVNAWAQSFDKLMLTPAGRNAFREFLRTEFSEENML 120

Query: 137 FWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQL 196
           FW AC   ++    +SN+    + AR IY  YI     I+S + + +  S ++  I + +
Sbjct: 121 FWMACEELKQ----ESNKSVIEEKARLIYEDYI----SILSPK-EVSLDSRVREVINRNM 171

Query: 197 IDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSE 236
           ++P+   FD AQ +I   M  ++YP F+ S IY +  R+ SE
Sbjct: 172 LEPSQHTFDDAQLQIYTLMHRDSYPRFMNSAIYKDLLRSLSE 213



>gi|15214238|sp|Q9UGC6|RGSH_HUMAN   Regulator of G-protein signaling 17 (RGS17)
          Length = 210

 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 11/137 (8%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           L W+++   ++    G +LFR FL+ E   + L FW AC   +K +     EEK    AR
Sbjct: 79  LSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEK----AR 134

Query: 163 AIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLID--PAMFDQAQTEIQATMEENTYPS 220
            IY  YI     I+S + + +  S ++  I + L+D  P M++ AQ +I   M  +++P 
Sbjct: 135 MIYEDYI----SILSPK-EVSLDSRVREVINRNLLDPNPHMYEDAQLQIYTLMHRDSFPR 189

Query: 221 FLKSDIYLEYTRTGSES 237
           FL S IY  +  + + S
Sbjct: 190 FLNSQIYKSFVESTAGS 206



>gi|18266795|sp|O76081|RGSK_HUMAN   Regulator of G-protein signaling 20 (RGS20) (Regulator of
           Gz-selective protein signaling 1) (Gz-selective
           GTPase-activating protein) (G(z)GAP)
          Length = 388

 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 46/150 (30%), Positives = 75/150 (50%), Gaps = 14/150 (9%)

Query: 92  PEGSASPTPPYLK---WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLE 148
           P    SP P   +   WA+S   L+    G + FR FL+ E   + + FW AC   +K  
Sbjct: 243 PTWEESPAPTLEEVNAWAQSFDKLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKKEA 302

Query: 149 PCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA--MFDQAQ 206
             +  EEK    AR IY  YI     I+S + + +  S ++  I + +++P+  +FD AQ
Sbjct: 303 NKNIIEEK----ARIIYEDYI----SILSPK-EVSLDSRVREVINRNMVEPSQHIFDDAQ 353

Query: 207 TEIQATMEENTYPSFLKSDIYLEYTRTGSE 236
            +I   M  ++YP F+ S +Y +  ++ SE
Sbjct: 354 LQIYTLMHRDSYPRFMNSAVYKDLLQSLSE 383



>gi|19855059|sp|O43566|RGSE_HUMAN   Regulator of G-protein signaling 14 (RGS14)
          Length = 594

 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 26/192 (13%)

Query: 45  VPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTP---- 100
           VP     L  +D   +S +   G+G G          R S L +   P G +SP P    
Sbjct: 10  VPNGRMVLAVSDGELSSTTGPQGQGEG----------RGSSLSIHSLPSGPSSPFPTEEQ 59

Query: 101 PYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKL 160
           P   WA S   LL D  G++ F  FLK+E  A+ + FW AC  F+++   D+  ++  + 
Sbjct: 60  PVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDT--QQLAQE 117

Query: 161 ARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLI---DPAMFDQAQTEIQATMEENT 217
           AR IY++++       S Q         +  + ++++    P MF   Q +I   M+ ++
Sbjct: 118 ARNIYQEFL-------SSQALSPVNIDRQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDS 170

Query: 218 YPSFLKSDIYLE 229
           Y  F+KS +Y E
Sbjct: 171 YARFVKSPLYRE 182



>gi|1730186|sp|P49795|RGS19_HUMAN   Regulator of G-protein signaling 19 (RGS19) (G-alpha interacting
           protein) (GAIP protein)
          Length = 217

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 56/197 (28%), Positives = 87/197 (44%), Gaps = 16/197 (8%)

Query: 38  EDAPRPPVPGEEGELVSTDP--RPASYSFCSGKGVGIKGETSTA--TPRRSDLDLGYEPE 93
           E+A RPP            P   P    +C         E   A    R S L      E
Sbjct: 15  EEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCE 74

Query: 94  GSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDS 152
             A+P+P  ++ WA+S   L+    G S+FR FL+ E   + + FW AC   +     ++
Sbjct: 75  VCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELK----AEA 130

Query: 153 NEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA--MFDQAQTEIQ 210
           N+    + AR IY  Y+     I+S + + +  S ++  I K++ +P+   FD AQ +I 
Sbjct: 131 NQHVVDEKARLIYEDYV----SILSPK-EVSLDSRVREGINKKMQEPSAHTFDDAQLQIY 185

Query: 211 ATMEENTYPSFLKSDIY 227
             M  ++YP FL S  Y
Sbjct: 186 TLMHRDSYPRFLSSPTY 202



>gi|2500170|sp|O08773|RGSE_RAT   Regulator of G-protein signaling 14 (RGS14)
          Length = 544

 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 47/170 (27%), Positives = 80/170 (47%), Gaps = 16/170 (9%)

Query: 67  GKGVGIKGETSTATPRRSDLDLGYEPEGSASP----TPPYLKWAESLHSLLDDQDGISLF 122
           G+     G  +    R S L +   P G +SP      P   WA+S   LL D  G++ F
Sbjct: 22  GELTSTSGSQAQGEGRGSSLSIHSLPSGPSSPFSTDEQPVASWAQSFERLLQDPRGLAYF 81

Query: 123 RTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKP 182
             FLK+E  A+ + FW AC  F+++   D+  ++  + A  IY ++      + S+   P
Sbjct: 82  TEFLKKEFSAENVTFWQACERFQQIPASDT--KQLAQEAHNIYHEF------LSSQALSP 133

Query: 183 AT---KSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 229
                ++++   ++ Q   P MF   Q +I   M+ ++Y  F+KS +Y E
Sbjct: 134 VNIDRQAWLSEEVLAQ-PRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQE 182



>gi|3914634|sp|P79348|RGSK_BOVIN   Regulator of G-protein signaling 20 (RGS20) (Retina-specific
           regulator of G-protein signaling) (RET-RGS1)
          Length = 374

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 43/134 (32%), Positives = 69/134 (51%), Gaps = 11/134 (8%)

Query: 105 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAI 164
           WA+S   L+    G + FR FL+ E   + + FW AC   +K     + EEK    AR I
Sbjct: 245 WAQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKATIEEK----ARII 300

Query: 165 YRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFL 222
           Y  YI     I+S + + +  S ++  I + + +P+  +FD AQ +I   M  ++YP F+
Sbjct: 301 YEDYI----SILSPK-EVSLDSRVRETINRSMAEPSRNIFDDAQLQIYTLMHRDSYPRFM 355

Query: 223 KSDIYLEYTRTGSE 236
            S +Y +  R+ SE
Sbjct: 356 NSALYKDLLRSLSE 369



>gi|3914636|sp|P97492|RGSE_MOUSE   Regulator of G-protein signaling 14 (RGS14) (RAP1/RAP2 interacting
           protein)
          Length = 547

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 47/170 (27%), Positives = 80/170 (47%), Gaps = 16/170 (9%)

Query: 67  GKGVGIKGETSTATPRRSDLDLGYEPEGSASP----TPPYLKWAESLHSLLDDQDGISLF 122
           G+     G  +    R S L +   P G +SP      P   WA+S   LL D  G++ F
Sbjct: 22  GELTSTAGSQAQGEGRGSSLSIHSLPSGPSSPFSTEEQPVASWAQSFERLLQDPRGLAYF 81

Query: 123 RTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKP 182
             FLK+E  A+ + FW AC  F+++   D+  ++  + A  IY ++      + S+   P
Sbjct: 82  TEFLKKEFSAENVTFWKACERFQQIPASDT--KQLAQEAHNIYHEF------LSSQALSP 133

Query: 183 AT---KSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 229
                ++++   ++ Q   P MF   Q +I   M+ ++Y  F+KS +Y E
Sbjct: 134 VNIDRQAWLSEEVLAQ-PRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQE 182



>gi|15214216|sp|Q9CX84|RGSJ_MOUSE   Regulator of G-protein signaling 19 (RGS19)
          Length = 216

 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 56/196 (28%), Positives = 79/196 (40%), Gaps = 14/196 (7%)

Query: 38  EDAPRPPVPGEEGELVSTDP--RPASYSFCSGKGVGIKGETSTA--TPRRSDLDLGYEPE 93
           E+A RPP         S  P   P    +C         E   A    R S L      E
Sbjct: 15  EEADRPPSMSSHDAAPSGPPSRNPCCLCWCCCCSCSWNQERQRAWQVSRESKLQPLPSCE 74

Query: 94  GSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDS 152
               P+P  ++ WA+S   L+    G S+FR FL+ E   + + FW AC   +     ++
Sbjct: 75  VCTPPSPKEVQSWAQSFDKLMHSPTGRSVFRAFLRTEYSEENMLFWLACEELK----AEA 130

Query: 153 NEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMK-QLIDPAMFDQAQTEIQA 211
           N+    + AR IY  Y+     I+S +         +G   K Q   P  FD AQ +I  
Sbjct: 131 NQHVVDEKARLIYEDYV----SILSPKEVSLDSRVREGINRKMQEPSPHTFDDAQLQIYT 186

Query: 212 TMEENTYPSFLKSDIY 227
            M  ++YP FL S  Y
Sbjct: 187 LMHRDSYPRFLTSPTY 202



>gi|3914622|sp|O14921|RGS13_HUMAN   Regulator of G-protein signaling 13 (RGS13)
          Length = 159

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 35/133 (26%), Positives = 70/133 (52%), Gaps = 11/133 (8%)

Query: 103 LKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLAR 162
           L+WA+S  +L+  + G  ++  +LK E   + + FW AC  ++K+    ++   R+  A+
Sbjct: 29  LQWAQSFENLMATKYGPVVYAAYLKMEHSDENIQFWMACETYKKI----ASRWSRISRAK 84

Query: 163 AIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDP--AMFDQAQTEIQATMEENTYPS 220
            +Y+ YI   +       +    S  +  I++ + +P    F++AQ  +   ME ++YP 
Sbjct: 85  KLYKIYIQPQS-----PREINIDSSTRETIIRNIQEPTETCFEEAQKIVYMHMERDSYPR 139

Query: 221 FLKSDIYLEYTRT 233
           FLKS++Y +  +T
Sbjct: 140 FLKSEMYQKLLKT 152



>gi|3913710|sp|O70521|RGSJ_RAT   Regulator of G-protein signaling 19 (RGS19) (G-alpha interacting
           protein) (GAIP protein)
          Length = 216

 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 57/196 (29%), Positives = 77/196 (39%), Gaps = 14/196 (7%)

Query: 38  EDAPRPPVPGEEGELVSTDP--RPASYSFCSGKGVGIKGETSTA--TPRRSDLDLGYEPE 93
           E+A RPP         S  P   P    +C         E   A    R S L      E
Sbjct: 15  EEADRPPSMSSHDAAPSGPPSRNPCCLCWCCCCSCSWNQERQRAWQVSRESKLQPLPSCE 74

Query: 94  GSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDS 152
               P+P  ++ WA+S   L+    G S+FR FL+ E   + + FW AC   +       
Sbjct: 75  VCTPPSPEEVQSWAQSFDKLMHSPTGRSVFRAFLRTEYSEENMLFWLACEELKTEADRHV 134

Query: 153 NEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMK-QLIDPAMFDQAQTEIQA 211
            +EK    AR IY  Y+     I+S +         +G   K Q   P  FD AQ +I  
Sbjct: 135 VDEK----ARLIYEDYV----SILSPKEVSLDSRVREGINRKMQEPSPHTFDDAQLQIYT 186

Query: 212 TMEENTYPSFLKSDIY 227
            M  ++YP FL S  Y
Sbjct: 187 LMHRDSYPRFLTSPTY 202



>gi|1731187|sp|P49808|RGS2_CAEEL   Regulator of G-protein signaling rgs-2
          Length = 169

 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 38/125 (30%), Positives = 65/125 (52%), Gaps = 11/125 (8%)

Query: 105 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAI 164
           W++S  +L+  + G   F  FLK E   + + FW AC   ++    + N EK  + AR I
Sbjct: 40  WSQSFENLMKHRAGQKYFAEFLKGEYSDENILFWQACEELKR----EKNAEKIEEKARII 95

Query: 165 YRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDP--AMFDQAQTEIQATMEENTYPSFL 222
           Y  +I     I+S + + +  S ++  +   +  P  + FD+AQ +I   M+ ++YP FL
Sbjct: 96  YEDFI----SILSPK-EVSLDSRVREIVNTNMGRPSASTFDEAQNQIYTLMQRDSYPRFL 150

Query: 223 KSDIY 227
            S+IY
Sbjct: 151 ASNIY 155



>gi|20141720|sp|P34295|RGS1_CAEEL   Regulator of G protein signaling rgs-1
          Length = 201

 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 48/168 (28%), Positives = 75/168 (44%), Gaps = 21/168 (12%)

Query: 64  FCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFR 123
           +CS  G    G   T +P+RS      +PE  A        W +S  +L+  + G   F 
Sbjct: 7   WCSNLGRKYSG---TVSPQRS-----VQPE--ALSYEMVYSWQQSFDTLMSFKSGQKCFA 56

Query: 124 TFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPA 183
            FLK E   + + FW AC   ++    + N EK  + AR IY  +I     I+S + + +
Sbjct: 57  EFLKSEYSDENILFWQACEELKR----EKNSEKMEEKARIIYEDFI----SILSPK-EVS 107

Query: 184 TKSFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 229
             S ++  +   +  P    F+ AQ +I   M  ++YP FL S  Y E
Sbjct: 108 LDSKVREIVNTNMSRPTQNTFEDAQHQIYQLMARDSYPRFLTSIFYRE 155



>gi|2500169|sp|O08774|RGSC_RAT   Regulator of G-protein signaling 12 (RGS12)
          Length = 1387

 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 41/132 (31%), Positives = 57/132 (43%), Gaps = 20/132 (15%)

Query: 105 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAI 164
           WA S   LL D  G+  F  FL++E   + + FW AC  F  +   D  E      AR I
Sbjct: 712 WAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELS--YRAREI 769

Query: 165 YRKYILDNNGIVSRQTKPATKSFIKGCIMKQLID-------PAMFDQAQTEIQATMEENT 217
           + K+      + S+ T P            QL D       P MF + Q +I   M+ ++
Sbjct: 770 FSKF------LCSKATTPVNID-----SQAQLADDILNAPHPDMFKEQQLQIFNLMKFDS 818

Query: 218 YPSFLKSDIYLE 229
           Y  FLKS +Y E
Sbjct: 819 YTRFLKSQLYQE 830



>gi|3914623|sp|O14924|RGSC_HUMAN   Regulator of G-protein signaling 12 (RGS12)
          Length = 1447

 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 41/132 (31%), Positives = 57/132 (43%), Gaps = 20/132 (15%)

Query: 105 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAI 164
           WA S   LL D  G+  F  FL++E   + + FW AC  F  +   D  E      AR I
Sbjct: 712 WAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELS--YRAREI 769

Query: 165 YRKYILDNNGIVSRQTKPATKSFIKGCIMKQLID-------PAMFDQAQTEIQATMEENT 217
           + K+      + S+ T P            QL D       P MF + Q +I   M+ ++
Sbjct: 770 FSKF------LCSKATTPVNID-----SQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDS 818

Query: 218 YPSFLKSDIYLE 229
           Y  FLKS +Y E
Sbjct: 819 YTRFLKSPLYQE 830



>gi|15214250|sp|Q9Z2H1|RGSB_MOUSE   Regulator of G-protein signaling 11 (RGS11)
          Length = 438

 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 8/124 (6%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +W+ S   LLDD  G + F  FL  E  A+ L FW AC   R        + +   L  +
Sbjct: 271 RWSFSFRELLDDPVGRAHFMDFLHNEFSAENLSFWEACEELR-----FGGQAQVPTLVDS 325

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLK 223
           +Y++++               +  ++G          + D AQ  I   M++++YP FLK
Sbjct: 326 VYQQFLAPGAARWINIDSRTMERTLEGLRQPHRY---VLDAAQLHIYMLMKKDSYPRFLK 382

Query: 224 SDIY 227
           SDIY
Sbjct: 383 SDIY 386



>gi|6919871|sp|O14641|DVL2_HUMAN   Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2)
           (DSH homolog 2)
          Length = 736

 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 26/73 (35%), Positives = 40/73 (54%), Gaps = 4/73 (5%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVRE 749
           V Y+   E  PY  +  V    +TLG FK +L +    +Y+FK +  +F  GVV EE+ +
Sbjct: 16  VIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDF--GVVKEEISD 73

Query: 750 DEAVLPVFEEKII 762
           D A LP F  +++
Sbjct: 74  DNARLPCFNGRVV 86



>gi|22096404|sp|Q18312|RGS3_CAEEL   Regulator of G protein signaling rgs-3
          Length = 363

 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 42/149 (28%), Positives = 62/149 (41%), Gaps = 8/149 (5%)

Query: 82  RRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFAC 141
           RRS+L L Y  E    P     KWA+S   LL +  G   FR FL+     + L FW A 
Sbjct: 216 RRSELYLEYLEE--LLPRSYAEKWAQSFEGLLGNHVGRHHFRIFLRSIHAEENLRFWEAV 273

Query: 142 TGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKP-ATKSFIKGCIMKQLIDPA 200
             FR              L + I   Y+ +  G  +    P   +  I+  I    ID  
Sbjct: 274 VEFRSSR---HKANAMNNLGKVILSTYLAE--GTTNEVFLPFGVRQVIERRIQDNQIDIT 328

Query: 201 MFDQAQTEIQATMEENTYPSFLKSDIYLE 229
           +FD+A   ++  +  + Y  FL+S  Y++
Sbjct: 329 LFDEAIKHVEQVLRNDPYVRFLQSSQYID 357



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 20/187 (10%)

Query: 45  VPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLK 104
           VP       S  P   S  F +G   G K + +   P     D G E   +AS       
Sbjct: 57  VPITNSSATSPTPSTGSMYFIAGMFDG-KEKVNREQPPMPTTD-GVEYPRAAS------- 107

Query: 105 WAE-SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           WA  +  ++L+D  G  LFR FL Q    + L F  A    +K++  D          + 
Sbjct: 108 WAAGNCANVLNDDKGKQLFRVFLFQSLAEENLAFLEAMEKLKKMKISDE---------KV 158

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLK 223
            Y K IL+        +  + KS ++  +  + +D   F  A  E++  +E + +P F +
Sbjct: 159 AYAKEILETYQGSINLSSSSMKS-LRNAVASETLDMEEFAPAIKEVRRLLENDQFPRFRR 217

Query: 224 SDIYLEY 230
           S++YLEY
Sbjct: 218 SELYLEY 224



>gi|6919872|sp|Q60838|DVL2_MOUSE   Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2)
           (DSH homolog 2)
          Length = 736

 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 26/73 (35%), Positives = 40/73 (54%), Gaps = 4/73 (5%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVRE 749
           V Y+   E  PY  +  V    +TLG FK +L +    +Y+FK +  +F  GVV EE+ +
Sbjct: 16  VIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDF--GVVKEEISD 73

Query: 750 DEAVLPVFEEKII 762
           D A LP F  +++
Sbjct: 74  DNARLPCFNGRVV 86



>gi|6919875|sp|Q92997|DVL3_HUMAN   Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3)
           (DSH homolog 3)
          Length = 716

 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 44/73 (60%), Gaps = 5/73 (6%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVRE 749
           + Y+  G+  PY  +  +    VTL  FK +L ++ SY+++FK + D+F  GVV EE+ +
Sbjct: 6   IIYHLDGQETPYLVKLPLPAERVTLADFKGVL-QRPSYKFFFKSMDDDF--GVVKEEISD 62

Query: 750 DEAVLPVFEEKII 762
           D A LP F  +++
Sbjct: 63  DNAKLPCFNGRVV 75



>gi|6919873|sp|Q61062|DVL3_MOUSE   Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3)
           (DSH homolog 3)
          Length = 716

 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 26/73 (35%), Positives = 44/73 (60%), Gaps = 5/73 (6%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVRE 749
           + Y+  G+  PY  +  +    VTL  FK +L ++ SY+++FK + D+F  GVV EE+ +
Sbjct: 6   IIYHLDGQETPYLVKLPLPAERVTLADFKGVL-QRPSYKFFFKSMDDDF--GVVKEEISD 62

Query: 750 DEAVLPVFEEKII 762
           D A LP F  +++
Sbjct: 63  DNAKLPCFNGRVV 75



>gi|6174947|sp|O94810|RGSB_HUMAN   Regulator of G-protein signaling 11 (RGS11)
          Length = 467

 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 44/173 (25%), Positives = 68/173 (39%), Gaps = 13/173 (7%)

Query: 60  ASYSFCSGKGVG--IKGETSTATPRRSDLDLGYEPEGSASPTPPYLK---WAESLHSLLD 114
           A  SFC  +G    +      + P  SD D  +         P  L+   W  S   LL+
Sbjct: 250 AYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLE 309

Query: 115 DQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNG 174
           D  G + F  FL +E   + L FW AC   R        + +   L  A+Y +++     
Sbjct: 310 DPVGRAHFMDFLGKEFSGENLSFWEACEELRY-----GAQAQVPTLVDAVYEQFLAPGAA 364

Query: 175 IVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIY 227
                     +  ++G          + D AQ  I   M++++YP FLKSD+Y
Sbjct: 365 HWVNIDSRTMEQTLEGLRQPHRY---VLDDAQLHIYMLMKKDSYPRFLKSDMY 414



>gi|1706527|sp|P51140|DSH_DROME   Segment polarity protein dishevelled
          Length = 623

 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 5/81 (6%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKGS-YRYYFKKVSDEFDCGVVFEEVR 748
           V Y+   E  PY  +  +    VTL  FK +L K+ + Y+Y+FK +  +F  GVV EE+ 
Sbjct: 13  VIYHIDDETTPYLVKIPIPSAQVTLRDFKLVLNKQNNNYKYFFKSMDADF--GVVKEEIA 70

Query: 749 EDEAVLPVFEEKIIGKVEKVD 769
           +D  +LP F  +++  +   D
Sbjct: 71  DDSTILPCFNGRVVSWLVSAD 91



>gi|8489001|sp|O54828|RGS9_MOUSE   Regulator of G-protein signaling 9 (RGS9)
          Length = 675

 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 37/134 (27%), Positives = 59/134 (44%), Gaps = 24/134 (17%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +WA +   L+ D  G   F+ FLK+E   + L FW AC   +       ++ K  + A  
Sbjct: 295 RWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKY-----GDQSKVKEKAEE 349

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIK------GCIMKQLIDPAMF--DQAQTEIQATMEE 215
           IY+ ++            P  + +I          +K L  P  +  D AQT I   M++
Sbjct: 350 IYKLFL-----------APGARRWINIDGKTMDITVKGLRHPHRYVLDAAQTHIYMLMKK 398

Query: 216 NTYPSFLKSDIYLE 229
           ++Y  +LKS IY E
Sbjct: 399 DSYARYLKSPIYKE 412



>gi|8489000|sp|P49805|RGS9_RAT   Regulator of G-protein signaling 9 (RGS9)
          Length = 677

 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 37/134 (27%), Positives = 59/134 (44%), Gaps = 24/134 (17%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +WA +   L+ D  G   F+ FLK+E   + L FW AC   +       ++ K  + A  
Sbjct: 295 RWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKY-----GDQSKVKEKAEE 349

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIK------GCIMKQLIDPAMF--DQAQTEIQATMEE 215
           IY+ ++            P  + +I          +K L  P  +  D AQT I   M++
Sbjct: 350 IYKLFL-----------APGARRWINIDGKTMDITVKGLRHPHRYVLDAAQTHIYMLMKK 398

Query: 216 NTYPSFLKSDIYLE 229
           ++Y  +LKS IY E
Sbjct: 399 DSYARYLKSPIYKE 412



>gi|8475983|sp|O75916|RGS9_HUMAN   Regulator of G-protein signaling 9 (RGS9)
          Length = 674

 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 36/132 (27%), Positives = 58/132 (43%), Gaps = 24/132 (18%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +WA +   L+ D  G   F+ FLK+E   + L FW AC   +       ++ K  + A  
Sbjct: 298 RWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACEDLKY-----GDQSKVKEKAEE 352

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIK------GCIMKQLIDPAMF--DQAQTEIQATMEE 215
           IY+ ++            P  + +I          +K L  P  +  D AQT I   M++
Sbjct: 353 IYKLFL-----------APGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKK 401

Query: 216 NTYPSFLKSDIY 227
           ++Y  +LKS IY
Sbjct: 402 DSYARYLKSPIY 413



>gi|3914628|sp|O46469|RGS9_BOVIN   Regulator of G-protein signaling 9 (RGS9)
          Length = 484

 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 36/134 (26%), Positives = 59/134 (44%), Gaps = 24/134 (17%)

Query: 104 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARA 163
           +WA +   L+ D  G   F+ FL++E   + L FW AC   +       ++ K  + A  
Sbjct: 295 RWAFNFSELIRDPKGRQSFQHFLRKEFSGENLGFWEACEDLKY-----GDQSKVKEKAEE 349

Query: 164 IYRKYILDNNGIVSRQTKPATKSFIK------GCIMKQLIDPAMF--DQAQTEIQATMEE 215
           IY+ ++            P  + +I          +K L  P  +  D AQT I   M++
Sbjct: 350 IYKLFL-----------APGARRWINIDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKK 398

Query: 216 NTYPSFLKSDIYLE 229
           ++Y  +LKS IY E
Sbjct: 399 DSYARYLKSPIYKE 412



>gi|20141291|sp|Q9WVB9|DVL1_RAT   Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1)
           (DSH homolog 1)
          Length = 695

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKG--SYRYYFKKVSDEFDCGVVFEEV 747
           + Y+   E  PY  +  V    VTL  FK +L+ +   +Y+++FK +  +F  GVV EE+
Sbjct: 6   IIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDF--GVVKEEI 63

Query: 748 REDEAVLPVFEEKII 762
            +D A LP F  +++
Sbjct: 64  FDDNAKLPCFNGRVV 78



>gi|6919870|sp|O14640|DVL1_HUMAN   Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1)
           (DSH homolog 1)
          Length = 670

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKG--SYRYYFKKVSDEFDCGVVFEEV 747
           + Y+   E  PY  +  V    VTL  FK +L+ +   +Y+++FK +  +F  GVV EE+
Sbjct: 6   IIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDF--GVVKEEI 63

Query: 748 REDEAVLPVFEEKII 762
            +D A LP F  +++
Sbjct: 64  FDDNAKLPCFNGRVV 78



>gi|1706528|sp|P54792|DVL1L_HUMAN   Segment polarity protein dishevelled homolog DVL-1-like
           (Dishevelled-1-like) (DSH homolog 1-like)
          Length = 670

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKG--SYRYYFKKVSDEFDCGVVFEEV 747
           + Y+   E  PY  +  V    VTL  FK +L+ +   +Y+++FK +  +F  GVV EE+
Sbjct: 6   IIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDF--GVVKEEI 63

Query: 748 REDEAVLPVFEEKII 762
            +D A LP F  +++
Sbjct: 64  FDDNAKLPCFNGRVV 78



>gi|1706529|sp|P51141|DVL1_MOUSE   Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1)
           (DSH homolog 1)
          Length = 695

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKG--SYRYYFKKVSDEFDCGVVFEEV 747
           + Y+   E  PY  +  V    VTL  FK +L+ +   +Y+++FK +  +F  GVV EE+
Sbjct: 6   IIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDF--GVVKEEI 63

Query: 748 REDEAVLPVFEEKII 762
            +D A LP F  +++
Sbjct: 64  FDDNAKLPCFNGRVV 78



>gi|20141813|sp|Q9Y5W7|SNXE_HUMAN   Sorting nexin 14
          Length = 886

 Score = 42.0 bits (97), Expect = 0.006
 Identities = 51/168 (30%), Positives = 71/168 (42%), Gaps = 29/168 (17%)

Query: 96  ASPTPPYL-KWAE-----------SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTG 143
           ASP  P+L K+AE            L  + + QD +  F  FLKQEG   +L F      
Sbjct: 261 ASPLVPFLQKFAEPRNKKPSVLKLELKQIREQQDLLFRFMNFLKQEGAVHVLQFCLTVEE 320

Query: 144 F--RKLEPCDSNEEKRLKL---ARAIYRKYILDNN--------GIVSRQTKPATKSFIKG 190
           F  R L P  SN+E  L L    + IY+ Y LD +         IV    + A   +I  
Sbjct: 321 FNDRILRPELSNDE-MLSLHEELQKIYKTYCLDESIDKIRFDPFIVEEIQRIAEGPYID- 378

Query: 191 CIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESP 238
            ++K      +F +A   + + +E    P F  SD Y      G+ESP
Sbjct: 379 -VVKLQTMRCLF-EAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESP 424



>gi|1706621|sp|P49809|EG10_CAEEL   Regulator of G-protein signaling egl-10 (Egg laying defective
           protein 10)
          Length = 555

 Score = 42.0 bits (97), Expect = 0.006
 Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 21/130 (16%)

Query: 105 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAI 164
           W +S   LL D  G    + FL +E   + L FW+     +KL  C S       +   I
Sbjct: 418 WEDSFEELLADSLGRETLQKFLDKEYSGENLRFWWE---VQKLRKCSSRMVP--VMVTEI 472

Query: 165 YRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAM-------FDQAQTEIQATMEENT 217
           Y ++I          T  AT      C + ++ +  +       FD+A   I   M+ ++
Sbjct: 473 YNEFI---------DTNAATSPVNVDCKVMEVTEDNLKNPNRWSFDEAADHIYCLMKNDS 523

Query: 218 YPSFLKSDIY 227
           Y  FL+S+IY
Sbjct: 524 YQRFLRSEIY 533



>gi|114151|sp|P21146|ARBK1_BOVIN   Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled
           receptor kinase 2)
          Length = 689

 Score = 41.2 bits (95), Expect = 0.011
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 6/115 (5%)

Query: 118 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 175
           G  LFR F  +  E    L++F+     + KLE     EE+RL  +R I+  YI+     
Sbjct: 64  GYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLE----TEEERLVCSREIFDTYIMKELLA 119

Query: 176 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 230
            S     +    ++G ++K+ + P +F     EI   +  + +  F++SD +  +
Sbjct: 120 CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174



>gi|1706530|sp|P51142|DVL2_XENLA   Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2)
           (DSH homolog 2) (Xdsh)
          Length = 736

 Score = 40.8 bits (94), Expect = 0.014
 Identities = 25/73 (34%), Positives = 39/73 (53%), Gaps = 5/73 (6%)

Query: 692 VAYYFCGEPIPY--RTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVRE 749
           V Y+   E  PY  +  V    + L  FK  L + G  +Y+FK +  +F  GVV EE+ +
Sbjct: 6   VIYHLDEEETPYLVKVPVPATDIRLRDFKAALGR-GHAKYFFKAMDQDF--GVVKEEISD 62

Query: 750 DEAVLPVFEEKII 762
           D A LP F ++++
Sbjct: 63  DNAKLPCFNDRVV 75



>gi|17380284|sp|P49802|RGS7_HUMAN   Regulator of G-protein signaling 7 (RGS7)
          Length = 495

 Score = 39.7 bits (91), Expect = 0.031
 Identities = 38/160 (23%), Positives = 65/160 (40%), Gaps = 9/160 (5%)

Query: 79  ATPRRSDLDLGYEPEGSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLLDF 137
           + P  SD    +E E S  P+   +K W   +   L D  G   F  FL+ E  ++ L F
Sbjct: 303 SNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRF 362

Query: 138 WFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLI 197
           W A    +K  P      +     + I+++++              +KS+ K     +  
Sbjct: 363 WLAVEDLKK-RPIKEVPSR----VQEIWQEFLAPG---APSAINLDSKSYDKTTQNVKEP 414

Query: 198 DPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSES 237
               F+ AQ  I   M+ ++YP F++S  Y E  +   +S
Sbjct: 415 GRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKS 454



>gi|114152|sp|P25098|ARBK1_HUMAN   Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled
           receptor kinase 2)
          Length = 689

 Score = 39.3 bits (90), Expect = 0.040
 Identities = 28/115 (24%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

Query: 118 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 175
           G  LFR F     E    L++F+     + KLE     EE+R+  +R I+  YI+     
Sbjct: 64  GYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLE----TEEERVARSREIFDSYIMKELLA 119

Query: 176 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 230
            S     +    ++G + K+ + P +F     EI   +  + +  F++SD +  +
Sbjct: 120 CSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174



>gi|3121776|sp|Q64682|ARBK1_MESAU   Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled
           receptor kinase 2)
          Length = 689

 Score = 39.3 bits (90), Expect = 0.040
 Identities = 28/115 (24%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

Query: 118 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 175
           G  LFR F     E    L++F+     + KLE     EE+R+  +R I+  YI+     
Sbjct: 64  GYLLFRDFCLNYLEEAKPLVEFYEEIKKYEKLE----TEEERVVRSREIFDSYIMKELLA 119

Query: 176 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 230
            S          ++G ++K+ + P +F     EI   +  + +  F++SD +  +
Sbjct: 120 CSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174



>gi|47605537|sp|Q99MK8|ARBK1_MOUSE   Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled
           receptor kinase 2)
          Length = 689

 Score = 39.3 bits (90), Expect = 0.040
 Identities = 28/115 (24%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

Query: 118 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 175
           G  LFR F     E    L++F+     + KLE     EE+R+  +R I+  YI+     
Sbjct: 64  GYLLFRDFCLNHLEEAKPLVEFYEEIKKYEKLE----TEEERVVRSREIFDSYIMKELLA 119

Query: 176 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 230
            S          ++G ++K+ + P +F     EI   +  + +  F++SD +  +
Sbjct: 120 CSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRF 174



>gi|114153|sp|P26817|ARBK1_RAT   Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled
           receptor kinase 2)
          Length = 689

 Score = 38.9 bits (89), Expect = 0.052
 Identities = 28/115 (24%), Positives = 51/115 (44%), Gaps = 6/115 (5%)

Query: 118 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGI 175
           G  LFR F     E    L++F+     + KLE     EE+R+  +R I+  YI+     
Sbjct: 64  GYLLFRDFYLNHLEEAKPLVEFYEEIEKYEKLE----TEEERVVRSREIFDSYIMKELLA 119

Query: 176 VSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 230
            S          ++G ++K+ + P +F     EI   +  + +  F++SD +  +
Sbjct: 120 CSHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFHKFIESDKFTRF 174



>gi|3914629|sp|O46470|RGS7_BOVIN   Regulator of G-protein signaling 7 (RGS7)
          Length = 469

 Score = 38.9 bits (89), Expect = 0.052
 Identities = 38/165 (23%), Positives = 66/165 (40%), Gaps = 9/165 (5%)

Query: 79  ATPRRSDLDLGYEPEGSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLLDF 137
           + P  SD    +E E S  P+   +K W   +   L D  G   F  FL+ E  ++ L F
Sbjct: 303 SNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRF 362

Query: 138 WFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLI 197
           W A    +K  P      +     + I+++++              +KS+ K     +  
Sbjct: 363 WLAVEDLKK-RPIREVPSR----VQEIWQEFLAPG---APSAINLDSKSYDKTTQNVKEP 414

Query: 198 DPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCS 242
               F+ AQ  I   M+ ++YP F++S  Y E  +   +   + S
Sbjct: 415 GRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKGKSLTS 459



>gi|13124775|sp|P49803|RGS7_RAT   Regulator of G-protein signaling 7 (RGS7)
          Length = 477

 Score = 38.5 bits (88), Expect = 0.069
 Identities = 37/152 (24%), Positives = 62/152 (40%), Gaps = 9/152 (5%)

Query: 79  ATPRRSDLDLGYEPEGSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLLDF 137
           + P  SD    +E E S  P+   +K W   +   L D  G   F  FL+ E  ++ L F
Sbjct: 303 SNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRF 362

Query: 138 WFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLI 197
           W A    +K  P      +     + I+++++              +KS+ K     +  
Sbjct: 363 WLAVEDLKK-RPIREVPSR----VQEIWQEFLAPG---APSAINLDSKSYDKTTQNVKEP 414

Query: 198 DPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 229
               F+ AQ  I   M+ ++YP F++S  Y E
Sbjct: 415 GRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQE 446



>gi|126752|sp|P26645|MACS_MOUSE   Myristoylated alanine-rich C-kinase substrate (MARCKS)
          Length = 309

 Score = 37.4 bits (85), Expect = 0.15
 Identities = 38/166 (22%), Positives = 61/166 (36%), Gaps = 13/166 (7%)

Query: 520 AKMPVALGGAASGHGKHVPKSGAKLDAAGLXXXXXXXXXXXXSTARPKEQVEAEATRRAQ 579
           AK  +   G+A    K  P SG+    A              + A  KE  EAE      
Sbjct: 54  AKEELQANGSAPAADKEEPASGSAATPAAAEKDEAAAATEPGAGAADKEAAEAEPA---- 109

Query: 580 SSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKA--ESGKSAST 637
                  EP S  A + G S S  ++P A DG A S       K+  + +  +S K +  
Sbjct: 110 -------EPSSPAAEAEGASASSTSSPKAEDGAAPSPSSETPKKKKKRFSFKKSFKLSGF 162

Query: 638 EVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRKVGGGS 683
               + +++ +  +      EG K+ +     G G  +  +  GG+
Sbjct: 163 SFKKSKKESGEGAEAEGATAEGAKDEAAAAAGGEGAAAPGEQAGGA 208



>gi|29337232|sp|Q18563|YCAK_CAEEL   Hypothetical protein C41G11.3 in chromosome X
          Length = 737

 Score = 36.6 bits (83), Expect = 0.26
 Identities = 27/108 (25%), Positives = 54/108 (50%), Gaps = 15/108 (13%)

Query: 122 FRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTK 181
           F+ FL+Q+ CA+ L+F+ A   F++++    + ++R    R I+ +Y   N+      T+
Sbjct: 32  FQEFLEQQFCAENLNFYLAVEQFKEIQ----DFQERSSFGRRIFDRYFAMNS------TE 81

Query: 182 P-----ATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKS 224
           P     +T   I+  +         +D AQ +I   ++ + +P FL+S
Sbjct: 82  PVNIDNSTSKRIRETVESGGFPLDTYDVAQYQILHLLKYDCWPRFLRS 129



>gi|23822106|sp|Q99PL5|RRB1_MOUSE   Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp)
          Length = 1605

 Score = 36.2 bits (82), Expect = 0.34
 Identities = 57/232 (24%), Positives = 88/232 (37%), Gaps = 36/232 (15%)

Query: 487 PESILDEHVQRVLRTPGRQSP---GPGHRSPDSGH-----VAKMPVALGGAASGHGKHVP 538
           PE  LD +V  +L+ P R S     P       GH     V  MP     ++    K   
Sbjct: 84  PEHDLDPNVTIILKEPVRVSAVAVAPTSVHSSVGHTPIATVPAMPQEKLASSPKDRKKKE 143

Query: 539 KSGAKLDAAGLXXXXXXXXXXXXST---ARPKE-------QVEAEATRRAQSSF------ 582
           K  AK++ A              S    A PKE        V ++A+  A SS       
Sbjct: 144 KKVAKVEPAVSSIVNSIQVLASKSAILEATPKEVPMVAVPPVGSKASSPATSSQGKKGQG 203

Query: 583 AWGLEPHSHGARSRGYS---------ESVGAAPNAS--DGLAHSGKVGVACKRNAKKAES 631
           A        GA+++G           +  GA   A   +G  + GK G   +  AKK E 
Sbjct: 204 AQNQAKKGEGAQNQGKKGEGAQNQAKKGEGAQNQAKKGEGAQNQGKKGEGAQNQAKKGEG 263

Query: 632 GKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRKVGGGS 683
           G++ + +  GA    +K +       +GE   ++ ++ G G ++Q K G G+
Sbjct: 264 GQNQAKKGEGAQNQGKKGEGAQNQGKKGEGAQNQAKK-GEGAQNQAKKGEGA 314



 Score = 34.3 bits (77), Expect = 1.3
 Identities = 23/95 (24%), Positives = 43/95 (45%), Gaps = 2/95 (2%)

Query: 592 GARSRGYS-ESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQ 650
           GA+++G   E         +G  + GK G   +  +KK E  ++ + +  G    A+K +
Sbjct: 434 GAQNQGKKPEGTSNQGKKGEGAQNQGKKGEGAQNQSKKGEGAQNQAKKGEGGQNQAKKGE 493

Query: 651 KIMQWIIEGEKEISRHRRTGHGTRSQRKVGGGSAQ 685
                  +GE   ++ ++ G G ++Q K G   AQ
Sbjct: 494 GAQNQAKKGEGAQNQAKK-GEGVQNQAKKGVEGAQ 527



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 6/95 (6%)

Query: 592 GARSRGYS-ESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQ 650
           GA+++G   E         +G  + GK G   +  AKK E  ++   +  GA    +K +
Sbjct: 635 GAQNQGKKGEGAQNQGKKGEGAQNQGKKGEGPQNQAKKGEGAQNQGKKGEGAQNQGKKGE 694

Query: 651 KIMQWIIEGEKE--ISRHRRTGHGTRSQRKVGGGS 683
                  +G+K   +    + G GT++Q K G G+
Sbjct: 695 GAQN---QGKKAEGVQSQSKKGEGTQNQGKKGDGN 726



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 18/71 (25%), Positives = 34/71 (47%)

Query: 610 DGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRT 669
           +G  +  K G   +  AKK E G++ + +  GA   A+K +       +GE   ++ ++ 
Sbjct: 463 EGAQNQSKKGEGAQNQAKKGEGGQNQAKKGEGAQNQAKKGEGAQNQAKKGEGVQNQAKKG 522

Query: 670 GHGTRSQRKVG 680
             G ++Q K G
Sbjct: 523 VEGAQNQGKKG 533



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 18/71 (25%), Positives = 34/71 (47%)

Query: 610 DGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRT 669
           +G  +  K G   +  AKK E G++ + +  GA   A+K +       +GE   ++ ++ 
Sbjct: 322 EGAQNQSKKGEGAQNQAKKGEGGQNQAKKGEGAQNQAKKGEGAQNQAKKGEGVQNQAKKG 381

Query: 670 GHGTRSQRKVG 680
             G ++Q K G
Sbjct: 382 VEGAQNQGKKG 392



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 27/123 (21%), Positives = 49/123 (39%), Gaps = 7/123 (5%)

Query: 569 QVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNAS------DGLAHSGKVGVAC 622
           Q +A+    AQ+    G    + G +  G          A       +G  + GK G   
Sbjct: 265 QNQAKKGEGAQNQGKKGEGAQNQGKKGEGAQNQAKKGEGAQNQAKKGEGAQNQGKKGEGA 324

Query: 623 KRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRKVGGG 682
           +  +KK E  ++ + +  G    A+K +       +GE   ++ ++ G G ++Q K G  
Sbjct: 325 QNQSKKGEGAQNQAKKGEGGQNQAKKGEGAQNQAKKGEGAQNQAKK-GEGVQNQAKKGVE 383

Query: 683 SAQ 685
            AQ
Sbjct: 384 GAQ 386



 Score = 32.0 bits (71), Expect = 6.4
 Identities = 29/124 (23%), Positives = 49/124 (39%), Gaps = 12/124 (9%)

Query: 569 QVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKK 628
           Q +A+    AQ+    G    +   +  G       A    +G  + GK G A +  AKK
Sbjct: 486 QNQAKKGEGAQNQAKKGEGAQNQAKKGEGVQNQ---AKKGVEGAQNQGKKGEANQNQAKK 542

Query: 629 AESGKSASTEVPGASEDAEKNQKIMQW--IIEGEKE-------ISRHRRTGHGTRSQRKV 679
            E G++ + +  G     +K +   +    IEG +         S   + G G ++Q K 
Sbjct: 543 GEGGQNQTKKGEGPQNQGKKGEAAQKQDKKIEGAQNQGKKPEGTSNQGKKGEGAQNQGKK 602

Query: 680 GGGS 683
           G G+
Sbjct: 603 GEGA 606



 Score = 32.0 bits (71), Expect = 6.4
 Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 1/73 (1%)

Query: 610 DGLAHSGKVGVACKRNAKKAESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRT 669
           +G  + GK G A ++  KK E  ++   +  G S   +K +       +GE   ++ ++ 
Sbjct: 413 EGPQNQGKKGEAAQKQDKKIEGAQNQGKKPEGTSNQGKKGEGAQNQGKKGEGAQNQSKK- 471

Query: 670 GHGTRSQRKVGGG 682
           G G ++Q K G G
Sbjct: 472 GEGAQNQAKKGEG 484



 Score = 32.0 bits (71), Expect = 6.4
 Identities = 29/124 (23%), Positives = 49/124 (39%), Gaps = 12/124 (9%)

Query: 569 QVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKK 628
           Q +A+    AQ+    G    +   +  G       A    +G  + GK G A +  AKK
Sbjct: 345 QNQAKKGEGAQNQAKKGEGAQNQAKKGEGVQNQ---AKKGVEGAQNQGKKGEANQNQAKK 401

Query: 629 AESGKSASTEVPGASEDAEKNQKIMQW--IIEGEKE-------ISRHRRTGHGTRSQRKV 679
            E G++ + +  G     +K +   +    IEG +         S   + G G ++Q K 
Sbjct: 402 GEGGQNQTKKGEGPQNQGKKGEAAQKQDKKIEGAQNQGKKPEGTSNQGKKGEGAQNQGKK 461

Query: 680 GGGS 683
           G G+
Sbjct: 462 GEGA 465



>gi|266495|sp|P30009|MACS_RAT   Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein
           kinase C substrate 80 kDa protein)
          Length = 309

 Score = 35.0 bits (79), Expect = 0.76
 Identities = 37/148 (25%), Positives = 50/148 (33%), Gaps = 30/148 (20%)

Query: 520 AKMPVALGGAASGHGKHVPKSGAKLDAAGLXXXXXXXXXXXXSTARPKEQVEAEATRRAQ 579
           AK  +   G+A    K  P SG     A              +    KE  EAE      
Sbjct: 54  AKEELQANGSAPAADKEEPASGGAATPAAADKDEAAAAPEPGAATADKEAAEAEPA---- 109

Query: 580 SSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAK------------ 627
                  EP S  A + G S S  ++P A DG A S       K+  +            
Sbjct: 110 -------EPGSPSAETEGASASSTSSPKAEDGAAPSPSSETPKKKKKRFSFKKSFKLSGF 162

Query: 628 -----KAESGKSASTEVPGASEDAEKNQ 650
                K E+G+ A  E  GA+ D  K++
Sbjct: 163 SFKKSKKEAGEGAEAE--GATADGAKDE 188



>gi|24418867|sp|Q9Y5W8|SNXD_HUMAN   Sorting nexin 13 (RGS domain- and PHOX domain-containing protein)
           (RGS-PX1)
          Length = 968

 Score = 35.0 bits (79), Expect = 0.76
 Identities = 36/146 (24%), Positives = 62/146 (42%), Gaps = 35/146 (23%)

Query: 109 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFR-----KLEPC---------DSNE 154
           L S+L D   +  F  +++Q G    L FW    G+R     +LE            +N+
Sbjct: 374 LDSILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQ 433

Query: 155 EKRLKLARA--IYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLID--------PAMFDQ 204
            K L  A A  IY +Y+ +         K + +  +   ++ +L D        P +FD 
Sbjct: 434 TKGLLRAAAVGIYEQYLSE---------KASPRVTVDDYLVAKLADTLNHEDPTPEIFDD 484

Query: 205 AQTEIQATM--EENTYPSFLKSDIYL 228
            Q ++   M  +E  YPSF ++ +Y+
Sbjct: 485 IQRKVYELMLRDERFYPSFRQNALYV 510



>gi|114154|sp|P26818|ARBK2_BOVIN   Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (G-protein coupled
           receptor kinase 3)
          Length = 688

 Score = 34.3 bits (77), Expect = 1.3
 Identities = 31/134 (23%), Positives = 54/134 (40%), Gaps = 11/134 (8%)

Query: 104 KWAESLHSLLDDQD-----GISLFRTFLKQE--GCADLLDFWFACTGFRKLEPCDSNEEK 156
           K+ E  H +  D+      G  LF+ F   E       + F+     + KLE    NEE 
Sbjct: 45  KYLEERHEITFDKIFNQRIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLE----NEED 100

Query: 157 RLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEEN 216
           RL  +R IY  YI+      S          ++  + K+ +   +F     EI  ++  +
Sbjct: 101 RLCRSRQIYDTYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGS 160

Query: 217 TYPSFLKSDIYLEY 230
            +  F++SD +  +
Sbjct: 161 IFQKFMESDKFTRF 174



>gi|114155|sp|P26819|ARBK2_RAT   Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (G-protein coupled
           receptor kinase 3)
          Length = 688

 Score = 33.9 bits (76), Expect = 1.7
 Identities = 25/121 (20%), Positives = 52/121 (42%), Gaps = 6/121 (4%)

Query: 112 LLDDQDGISLFRTFLKQE--GCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYI 169
           + + + G  LF+ F   E       + F+     + KL+    NEE RL  +R +Y  YI
Sbjct: 58  IFNQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLD----NEEDRLHRSRQMYDAYI 113

Query: 170 LDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 229
           +      + Q        ++  + K+ + P +F     EI  ++  + +  F++S+ +  
Sbjct: 114 MRELLSSTHQFSKQAVEHVQSHLSKKQVTPTLFQPYIEEICESLRGDIFQKFMESEKFTR 173

Query: 230 Y 230
           +
Sbjct: 174 F 174



>gi|118938|sp|P13922|DRTS_PLAFK   Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS)
           [Includes: Dihydrofolate reductase ; Thymidylate
           synthase ]
          Length = 608

 Score = 33.5 bits (75), Expect = 2.2
 Identities = 15/49 (30%), Positives = 28/49 (57%), Gaps = 3/49 (6%)

Query: 703 YRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDE 751
           Y+  + G +V    ++E L KK   + YF +++  ++C V F E+ E+E
Sbjct: 159 YKCFIIGGSVV---YQEFLEKKLIKKIYFTRINSTYECDVFFPEINENE 204



>gi|3915327|sp|O51067|Y038_BORBU   Hypothetical protein BB0038
          Length = 505

 Score = 32.7 bits (73), Expect = 3.8
 Identities = 12/42 (28%), Positives = 26/42 (61%)

Query: 724 KGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKV 765
           K SY  Y + ++ ++D  +V +   +D++VL VF++ ++  V
Sbjct: 140 KNSYNMYLEDITGDYDFNIVIQGFLKDKSVLYVFQKSVLNDV 181



>gi|2851457|sp|Q40963|MP5B_PHLPR   Pollen allergen Phl p 5b precursor (Phl p Vb)
          Length = 284

 Score = 32.3 bits (72), Expect = 4.9
 Identities = 29/104 (27%), Positives = 41/104 (39%), Gaps = 6/104 (5%)

Query: 508 GPGHR-SPDSGHVAKMPVALGGAASGHGKHVPKSGAKLDAAGLXXXXXXXXXXXXSTARP 566
           GPG   + D+G+    P A G AA   GK   +    ++   +              A  
Sbjct: 13  GPGRSYTADAGYAPATPAAAGAAA---GKATTEEQKLIEDINVGFKAAVAAAASVPAADK 69

Query: 567 KEQVEAEATR--RAQSSFAWGLEPHSHGARSRGYSESVGAAPNA 608
            +  EA  T   +A ++ A GL P    A S  Y  +VGA P A
Sbjct: 70  FKTFEAAFTSSSKAAAAKAPGLVPKLDAAYSVAYKAAVGATPEA 113



>gi|543848|sp|P35626|ARBK2_HUMAN   Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (G-protein coupled
           receptor kinase 3)
          Length = 688

 Score = 32.3 bits (72), Expect = 4.9
 Identities = 26/121 (21%), Positives = 50/121 (41%), Gaps = 6/121 (4%)

Query: 112 LLDDQDGISLFRTFLKQE--GCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYI 169
           + + + G  LF+ F   E       + F+     + KL+    NEE RL  +R IY  YI
Sbjct: 58  IFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLD----NEEDRLCRSRQIYDAYI 113

Query: 170 LDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 229
           +      S          ++  + K+ +   +F     EI  ++  + +  F++SD +  
Sbjct: 114 MKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTR 173

Query: 230 Y 230
           +
Sbjct: 174 F 174



>gi|60389868|sp|Q810W7|MAST1_RAT   Microtubule-associated serine/threonine-protein kinase 1
            (Syntrophin-associated serine/threonine-protein kinase)
          Length = 1570

 Score = 32.0 bits (71), Expect = 6.4
 Identities = 19/53 (35%), Positives = 24/53 (45%), Gaps = 3/53 (5%)

Query: 37   TEDAPR---PPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDL 86
            T++ PR   PPVP     +  T P   S S C  +GV   G T T  P  + L
Sbjct: 1516 TKNVPRSAAPPVPPASLMVPGTKPEAGSNSRCPAEGVASAGLTKTGAPSPASL 1568



>gi|3024533|sp|P97844|RGS1_RAT   Regulator of G-protein signaling 1 (RGS1)
          Length = 81

 Score = 32.0 bits (71), Expect = 6.4
 Identities = 13/34 (38%), Positives = 21/34 (61%)

Query: 115 DQDGISLFRTFLKQEGCADLLDFWFACTGFRKLE 148
           +Q G ++F  FLK E   + ++FW AC  ++K E
Sbjct: 2   NQMGQNVFGKFLKSEFSEENIEFWLACEDYKKTE 35



>gi|22261815|sp|P49758|RGS6_HUMAN   Regulator of G-protein signaling 6 (RGS6) (S914)
          Length = 567

 Score = 32.0 bits (71), Expect = 6.4
 Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 1/58 (1%)

Query: 90  YEPEGSASPTPPYLK-WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRK 146
           ++ E S  P+   +K W  S   +L DQ G   F  FL+ E  ++ L FW A    +K
Sbjct: 317 WDIEMSKDPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKK 374



>gi|46397733|sp|Q8SX83|SPEN_DROME   Split ends protein
          Length = 5560

 Score = 31.6 bits (70), Expect = 8.4
 Identities = 28/125 (22%), Positives = 47/125 (37%), Gaps = 12/125 (9%)

Query: 565  RPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKR 624
            R K+Q E E   + QS  A  +E    G R R  S    +  + +     S    + C+ 
Sbjct: 2047 REKDQREREHREKEQSRRAMDVEQEGRGGRMRELSSYQKSKMDIAG--EASSLTAIDCQH 2104

Query: 625  NAKK-----AESGKSASTEVPGASEDAEKNQKIMQWIIEGEKEISRHRRTGHGTRSQRKV 679
            N +      A+    AS   P  +   E+++K+ +        +  H+R      S    
Sbjct: 2105 NKENAMDTIAQGTPGASPSTPSDNTPKERSRKLSR-----NSPVRLHKRRLSSQESNHSA 2159

Query: 680  GGGSA 684
            GGG +
Sbjct: 2160 GGGGS 2164



>gi|6093748|sp|O13898|PMTX_SCHPO   Probable dolichyl-phosphate-mannose--protein mannosyltransferase
           C22A12.07c
          Length = 893

 Score = 31.6 bits (70), Expect = 8.4
 Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 13/83 (15%)

Query: 567 KEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNA 626
           +++ E EA   A+ + +   E  S  A +   SESV AA              V  +R A
Sbjct: 783 QQKAEQEAREAAEKAASEAAERSSSEAAASSSSESVAAA-------------SVEAERLA 829

Query: 627 KKAESGKSASTEVPGASEDAEKN 649
            +A+    AS  V GAS +AE++
Sbjct: 830 MEADEFNGASETVDGASVEAERS 852



>gi|9911089|sp|P03764|STF_LAMBD   Side tail fiber protein
          Length = 774

 Score = 31.6 bits (70), Expect = 8.4
 Identities = 24/93 (25%), Positives = 39/93 (41%)

Query: 562 STARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVA 621
           STA  K+     +   AQ +        S  A S    ++  +A  AS G   +      
Sbjct: 123 STADAKKSAGDASASAAQVAALVTDATDSARAASTSAGQAASSAQEASSGAEAASAKATE 182

Query: 622 CKRNAKKAESGKSASTEVPGASEDAEKNQKIMQ 654
            +++A  AES K+A+    GA++ +E N    Q
Sbjct: 183 AEKSAAAAESSKNAAATSAGAAKTSETNAAASQ 215






  Database: Non-redundant SwissProt sequences
    Posted date:  Mar 15, 2005 10:11 AM
  Number of letters in database: 60,490,055
  Number of sequences in database:  164,271
  
Lambda     K      H
   0.314    0.133    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,495,144
Number of Sequences: 164271
Number of extensions: 707074
Number of successful extensions: 1366
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1301
Number of HSP's gapped (non-prelim): 42
length of query: 769
length of database: 60,490,055
effective HSP length: 118
effective length of query: 651
effective length of database: 41,106,077
effective search space: 26760056127
effective search space used: 26760056127
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)