BLASTP 2.2.10 [Oct-19-2004] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. RID: 1111138257-18955-112106929505.BLASTQ4 Query= ENr123_FGENESH_gen3 43 exon (s) 278725 - 421358 2111 aa, chain + (2111 letters) Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples 2,367,365 sequences; 802,797,248 total letters Score E Sequences producing significant alignments: (bits) Value gi|55740398|gb|AAV63975.1| leucine-rich repeat kinase 2 [Homo sa... 3303 0.0 gi|41149741|ref|XP_058513.7| PREDICTED: similar to RIKEN cDNA 49... 3303 0.0 gi|34534766|dbj|BAC87105.1| unnamed protein product [Homo sapiens] 1132 0.0 gi|21740356|emb|CAD39185.1| hypothetical protein [Homo sapiens] 631 e-180 gi|14017797|dbj|BAB47419.1| KIAA1790 protein [Homo sapiens] 161 1e-38 gi|33469143|ref|NP_078928.2| leucine-rich repeat kinase 1 [Homo ... 147 2e-34 gi|4758704|ref|NP_004216.1| malignant fibrous histiocytoma ampli... 108 9e-23 gi|34526495|dbj|BAC85125.1| FLJ00262 protein [Homo sapiens] 102 7e-21 gi|31416932|gb|AAH05408.2| LRRK1 protein [Homo sapiens] 102 7e-21 gi|55661683|emb|CAH72812.1| OTTHUMP00000058851 [Homo sapiens] >g... 95 2e-18 gi|40788390|dbj|BAA74885.2| KIAA0862 protein [Homo sapiens] 95 2e-18 gi|55661684|emb|CAH72813.1| soc-2 suppressor of clear homolog (C... 94 4e-18 gi|32812252|gb|AAP88017.1| CRIB1 [Homo sapiens] >gi|45827729|ref... 88 2e-16 gi|32812254|gb|AAP88018.1| SCRIB1 variant N1 [Homo sapiens] 88 2e-16 gi|45827731|ref|NP_874365.2| scribble isoform a [Homo sapiens] 88 2e-16 gi|18032008|gb|AAL38976.1| scribble [Homo sapiens] 88 2e-16 gi|56205237|emb|CAI22332.1| novel protein [Homo sapiens] >gi|104... 86 8e-16 gi|32425389|gb|AAH03407.2| FLJ20331 protein [Homo sapiens] 86 8e-16 gi|51094908|gb|EAL24153.1| similar to hypothetical protein 49324... 83 5e-15 gi|56204430|emb|CAI22426.1| OTTHUMP00000065337 [Homo sapiens] >g... 82 1e-14 gi|56204429|emb|CAI22425.1| OTTHUMP00000065336 [Homo sapiens] >g... 82 1e-14 gi|51476914|emb|CAH18423.1| hypothetical protein [Homo sapiens] 82 1e-14 gi|29791785|gb|AAH50692.1| ERBB2IP protein [Homo sapiens] 81 2e-14 gi|55770895|ref|NP_001006600.1| ERBB2 interacting protein isofor... 81 2e-14 gi|8923909|ref|NP_061165.1| ERBB2 interacting protein isoform 2 ... 81 2e-14 gi|14582259|gb|AAK69431.1| densin-180-like protein [Homo sapiens... 81 2e-14 gi|13112035|gb|AAH03193.1| LRRC1 protein [Homo sapiens] >gi|5596... 80 5e-14 gi|37221175|ref|NP_919431.1| suprachiasmatic nucleus circadian o... 80 6e-14 gi|422993|pir||JU0229 mixed-lineage protein kinase 1 - human >gi... 80 6e-14 gi|34809548|gb|AAH14927.2| PLEKHE1 protein [Homo sapiens] 80 6e-14 gi|7023489|dbj|BAA91980.1| unnamed protein product [Homo sapiens] 80 6e-14 gi|20521103|dbj|BAA25532.2| KIAA0606 protein [Homo sapiens] 80 6e-14 gi|52421790|ref|NP_149132.2| mitogen-activated protein kinase ki... 79 1e-13 gi|33591094|gb|AAQ23054.1| mixed-lineage protein kinase 1 [Homo ... 79 1e-13 gi|12005724|gb|AAG44591.1| mixed lineage kinase MLK1 [Homo sapiens] 79 1e-13 gi|21450844|ref|NP_647611.1| megakaryocyte-associated tyrosine k... 77 3e-13 gi|21450846|ref|NP_647612.1| megakaryocyte-associated tyrosine k... 77 3e-13 gi|21450842|ref|NP_002369.2| megakaryocyte-associated tyrosine k... 77 3e-13 gi|559594|gb|AAB30995.1| leukocyte carboxyl-terminal src kinase ... 77 4e-13 gi|14916455|ref|NP_149117.1| protein serine kinase H2 [Homo sapi... 75 1e-12 gi|55958775|emb|CAI16469.1| fyn-related kinase [Homo sapiens] >g... 75 1e-12 gi|54696178|gb|AAV38461.1| mitogen-activated protein kinase kina... 75 1e-12 gi|732528|gb|AAC50116.1| Rak 75 1e-12 gi|29124496|gb|AAH48960.1| Viral oncogene yes-1 homolog 1 [Homo ... 74 3e-12 gi|1082750|pir||A49865 protein-tyrosine kinase (EC 2.7.1.112) ma... 74 3e-12 gi|2392699|pdb|2HCK|B Chain B, Src Family Kinase Hck-Quercetin C... 74 3e-12 gi|7981277|emb|CAB91984.1| protein serine kinase [Homo sapiens] ... 74 4e-12 gi|56204061|emb|CAI23531.1| MAP3K7 [Homo sapiens] >gi|56203689|e... 73 6e-12 gi|56204060|emb|CAI23530.1| MAP3K7 [Homo sapiens] >gi|56203690|e... 73 6e-12 gi|56204062|emb|CAI23532.1| MAP3K7 [Homo sapiens] >gi|56203692|e... 73 6e-12 gi|56204063|emb|CAI23533.1| MAP3K7 [Homo sapiens] >gi|56203691|e... 73 6e-12 gi|54696176|gb|AAV38460.1| mitogen-activated protein kinase kina... 73 6e-12 gi|4507277|ref|NP_003148.1| NIMA (never in mitosis gene a)-relat... 73 6e-12 gi|7513397|pir||JC5957 transforming growth factor-beta activated... 73 6e-12 gi|38648684|gb|AAH63044.1| NEK4 protein [Homo sapiens] 73 6e-12 gi|56462535|emb|CAI16055.1| TEK tyrosine kinase, endothelial (ve... 73 7e-12 gi|4557869|ref|NP_000450.1| TEK tyrosine kinase, endothelial [Ho... 73 7e-12 gi|15988251|pdb|1FVR|B Chain B, Tie2 Kinase Domain >gi|15988250|... 73 7e-12 gi|47524177|ref|NP_075252.2| fibroblast growth factor receptor 4... 72 1e-11 gi|21595367|gb|AAH32413.1| B lymphoid tyrosine kinase [Homo sapi... 72 1e-11 gi|15080148|gb|AAH11847.1| Fibroblast growth factor receptor 4, ... 72 1e-11 gi|476558|pir||TVHUF4 fibroblast growth factor receptor 4 precur... 72 1e-11 gi|23273968|gb|AAH35514.1| TEK protein [Homo sapiens] 72 1e-11 gi|20153207|gb|AAM13666.1| fibroblast growth factor receptor 4 [... 72 1e-11 gi|18250298|ref|NP_543013.1| src-related kinase lacking C-termin... 72 1e-11 gi|13991618|gb|AAK51435.1| fibroblast growth factor receptor 4 v... 72 1e-11 gi|6739818|gb|AAF27432.1| fibroblast growth factor receptor 4, s... 72 1e-11 gi|2117797|pir||I37206 protein-tyrosine kinase (EC 2.7.1.112) bl... 72 1e-11 gi|2832350|emb|CAA74200.1| fibroblast growth factor 4 [Homo sapi... 72 1e-11 gi|21735550|ref|NP_002437.2| mitogen-activated protein kinase ki... 72 1e-11 gi|971420|emb|CAA62351.1| mixed lineage kinase 2 [Homo sapiens] ... 72 1e-11 gi|758593|emb|CAA88531.1| serine/threonine kinase with SH3 domai... 72 1e-11 gi|914204|gb|AAB33265.1| protein tyrosine kinase [Homo sapiens] 72 1e-11 gi|56203175|emb|CAI22966.1| HCK [Homo sapiens] >gi|56205100|emb|... 72 2e-11 gi|306832|gb|AAA52643.1| protein-tyrosine kinase 72 2e-11 gi|30795229|ref|NP_002101.2| hemopoietic cell kinase isoform p61... 72 2e-11 gi|56203176|emb|CAI22967.1| HCK [Homo sapiens] >gi|56205101|emb|... 72 2e-11 gi|10439296|dbj|BAB15482.1| unnamed protein product [Homo sapiens] 72 2e-11 gi|19923729|ref|NP_115646.2| hypothetical protein AD158 [Homo sa... 72 2e-11 gi|50949358|emb|CAB66853.2| hypothetical protein [Homo sapiens] 72 2e-11 gi|5542349|pdb|1QCF|A Chain A, Crystal Structure Of Hck In Compl... 72 2e-11 gi|5804911|emb|CAA41565.2| tyrosine kinase [Homo sapiens] 72 2e-11 gi|56204189|emb|CAI23046.1| mixed lineage kinase 4 (KIAA1804) [H... 71 3e-11 gi|4503743|ref|NP_002009.1| flightless I homolog [Homo sapiens] ... 71 3e-11 gi|56204188|emb|CAI23045.1| mixed lineage kinase 4 (KIAA1804) [H... 71 3e-11 gi|2135121|pir||A49674 flightless-I homolog - human (fragment) >... 71 3e-11 gi|5174647|ref|NP_005966.1| PTK6 protein tyrosine kinase 6 [Homo... 70 4e-11 gi|37181696|gb|AAQ88655.1| SAPS287 [Homo sapiens] >gi|40255157|r... 70 5e-11 gi|47458813|ref|NP_006242.4| protein kinase, AMP-activated, alph... 70 5e-11 gi|20178277|sp|Q13131|AAPK1_HUMAN 5'-AMP-activated protein kinas... 70 5e-11 gi|50845418|ref|NP_065973.2| WNK lysine deficient protein kinase... 70 6e-11 gi|30016945|gb|AAP03432.1| v-raf-1 murine leukemia viral oncogen... 70 6e-11 gi|4826878|ref|NP_005100.1| oxidative-stress responsive 1 [Homo ... 70 6e-11 gi|57284054|emb|CAI43129.1| protein kinase, lysine deficient 3 [... 70 6e-11 gi|57284053|emb|CAI43128.1| protein kinase, lysine deficient 3 [... 70 6e-11 gi|40789046|dbj|BAA83053.2| KIAA1101 protein [Homo sapiens] 70 6e-11 gi|19908348|gb|AAL99253.1| putative protein kinase WNK3 [Homo sa... 70 6e-11 gi|496091|gb|AAA60247.1| RAF1 70 6e-11 gi|227082|prf||1613537A c-raf1 protooncogene 70 6e-11 gi|55961054|emb|CAI13543.1| mitogen-activated protein kinase-act... 69 1e-10 gi|4502557|ref|NP_001735.1| calcium/calmodulin-dependent protein... 69 1e-10 gi|32481209|ref|NP_116584.2| mitogen-activated protein kinase-ac... 69 1e-10 gi|54035072|gb|AAH16695.2| CAMK4 protein [Homo sapiens] 69 1e-10 gi|4758284|ref|NP_004432.1| ephrin receptor EphB1 precursor [Hom... 69 1e-10 gi|19263755|gb|AAH25307.1| PRKD2 protein [Homo sapiens] 69 1e-10 gi|22760266|dbj|BAC11127.1| unnamed protein product [Homo sapiens] 69 1e-10 gi|22761242|dbj|BAC11508.1| unnamed protein product [Homo sapiens] 69 1e-10 gi|7019543|ref|NP_037365.1| serine threonine kinase 39 (STE20/SP... 69 1e-10 gi|19923468|ref|NP_057541.2| protein kinase D2 [Homo sapiens] >g... 69 1e-10 gi|17736731|emb|CAC84640.1| mixed lineage kinase 4beta [Homo sap... 69 1e-10 gi|17736729|emb|CAC84639.1| mixed lineage kinase 4alpha [Homo sa... 69 1e-10 gi|27769064|gb|AAH42334.1| Similar to RIKEN cDNA 1300018K11 gene... 69 1e-10 gi|4884154|emb|CAB43292.1| hypothetical protein [Homo sapiens] >... 69 1e-10 gi|49457444|emb|CAG47021.1| STK17B [Homo sapiens] 69 1e-10 gi|2144413|pir||TVHUBF protein kinase B-raf (EC 2.7.1.-) - human 68 2e-10 gi|12314068|emb|CAC12717.1| GD:STK6 [Homo sapiens] >gi|38327570|... 68 2e-10 gi|4502553|ref|NP_003647.1| calcium/calmodulin-dependent protein... 68 2e-10 gi|51094777|gb|EAL24023.1| v-raf murine sarcoma viral oncogene h... 68 2e-10 gi|56792342|gb|AAW30454.1| AKAP9-BRAF fusion protein [Homo sapiens] 68 2e-10 gi|12803361|gb|AAH02499.1| STK6 protein [Homo sapiens] >gi|20073... 68 2e-10 gi|19424132|ref|NP_598001.1| NIMA (never in mitosis gene a)-rela... 68 2e-10 gi|11125348|emb|CAC15059.1| putative protein kinase [Homo sapien... 68 2e-10 gi|6933864|gb|AAF31483.1| kinase deficient protein KDP [Homo sap... 68 2e-10 gi|6851302|gb|AAF29508.1| STK15 serine/threonine kinase [Homo sa... 68 2e-10 gi|5441948|gb|AAD43193.1| serine/threonine protein kinase; simil... 68 2e-10 gi|4103971|gb|AAD01901.1| Ste20-like protein kinase [Homo sapiens] 68 2e-10 gi|7446411|pir||JC5974 aurora-related kinase 1 (EC 2.7.-.-) - human 68 2e-10 gi|47169341|pdb|1UWH|B Chain B, The Complex Of Wild Type B-Raf A... 68 2e-10 gi|37926805|pdb|1MQ4|A Chain A, Crystal Structure Of Aurora-A Pr... 68 2e-10 gi|30749504|pdb|1MUO|A Chain A, Crystal Structure Of Aurora-2, A... 68 2e-10 gi|179535|gb|AAA96495.1| B-raf protein 68 2e-10 gi|20521007|dbj|BAA20802.2| KIAA0344 [Homo sapiens] 68 2e-10 gi|14602490|gb|AAH09751.1| Aurora kinase B [Homo sapiens] 68 2e-10 gi|56202636|emb|CAI19991.1| calcium/calmodulin-dependent protein... 68 2e-10 gi|1161364|gb|AAB60412.1| tyrosine kinase 68 2e-10 gi|37727961|gb|AAR02359.1| interleukin-1 receptor-associated kin... 68 2e-10 gi|1848077|emb|CAA26485.1| c-src [Homo sapiens] 68 2e-10 gi|4758194|ref|NP_004217.1| serine/threonine kinase 17b (apoptos... 68 2e-10 gi|15079460|gb|AAH11566.1| SRC protein [Homo sapiens] >gi|559309... 68 2e-10 gi|4557511|ref|NP_001339.1| death-associated protein kinase 3 [H... 68 2e-10 gi|33870194|gb|AAH13300.2| AURKB protein [Homo sapiens] 68 2e-10 gi|20219010|gb|AAM15772.1| interleukin-1 receptor associated kin... 68 2e-10 gi|30271862|gb|AAP29964.1| CLICK III [Homo sapiens] 68 2e-10 gi|56205021|emb|CAI22921.1| GD:SRC [Homo sapiens] >gi|10436623|d... 68 2e-10 gi|10635153|emb|CAC10573.1| GD:SRC [Homo sapiens] >gi|625219|pir... 68 2e-10 gi|7023013|dbj|BAA91801.1| unnamed protein product [Homo sapiens] 68 2e-10 gi|4678722|emb|CAB41259.1| hypothetical protein [Homo sapiens] 68 2e-10 gi|37727969|gb|AAR02363.1| interleukin-1 receptor-associated kin... 68 2e-10 gi|4507743|ref|NP_003319.1| TXK tyrosine kinase [Homo sapiens] >... 68 2e-10 gi|16755792|gb|AAL28100.1| calcium/calmodulin-dependent protein ... 68 2e-10 gi|47169343|pdb|1UWJ|B Chain B, The Complex Of Mutant V599e B-Ra... 68 2e-10 gi|56404655|sp|Q96NX5|KCC1G_HUMAN Calcium/calmodulin-dependent p... 68 2e-10 gi|5822499|pdb|2SRC| Crystal Structure Of Human Tyrosine-Protei... 68 2e-10 gi|56208156|emb|CAI22301.1| FYN oncogene related to SRC, FGR, YE... 67 3e-10 gi|56208155|emb|CAI22300.1| FYN oncogene related to SRC, FGR, YE... 67 3e-10 gi|5031689|ref|NP_005804.1| protein kinase D3 [Homo sapiens] >gi... 67 3e-10 gi|56208154|emb|CAI22299.1| FYN oncogene related to SRC, FGR, YE... 67 3e-10 gi|21618480|gb|AAH32496.1| Protein-tyrosine kinase fyn, isoform ... 67 3e-10 gi|18265389|gb|AAL67158.1| zipper protein kinase [Homo sapiens] 67 4e-10 gi|37181368|gb|AAQ88498.1| densin hlg [Homo sapiens] >gi|5566503... 67 4e-10 gi|4506075|ref|NP_002733.1| protein kinase D1 [Homo sapiens] >gi... 67 4e-10 gi|29476775|gb|AAH50050.1| MAP3K12 protein [Homo sapiens] 67 4e-10 gi|56204512|emb|CAI23271.1| protein kinase N2 [Homo sapiens] >gi... 67 4e-10 gi|55665040|emb|CAH72254.1| OTTHUMP00000012587 [Homo sapiens] 67 4e-10 gi|2641948|dbj|BAA23592.1| aurora/IPL1-related kinase [Homo sapi... 67 4e-10 gi|47458815|ref|NP_996790.2| protein kinase, AMP-activated, alph... 67 4e-10 gi|21735552|ref|NP_006292.2| mitogen-activated protein kinase ki... 67 4e-10 gi|29124503|gb|AAH48980.1| PRKAA1 protein [Homo sapiens] 67 4e-10 gi|4104413|gb|AAD02031.1| Eph-like receptor tyrosine kinase hEph... 67 4e-10 gi|2136035|pir||I38138 protein-serine kinase (EC 2.7.1.-) PSK-H1... 67 4e-10 gi|631347|pir||JC2363 protein kinase (EC 2.7.1.37) ZPK - human 67 4e-10 gi|18202489|sp|Q12852|M3K12_HUMAN Mitogen-activated protein kina... 67 4e-10 gi|20151029|pdb|1KSW|A Chain A, Structure Of Human C-Src Tyrosin... 67 4e-10 gi|1362858|pir||A56708 MAPK/ERK kinase 5 - human 67 5e-10 gi|56203182|emb|CAC17574.2| protein kinase, AMP-activated, alpha... 67 5e-10 gi|758367|gb|AAA64745.1| AMP-activated protein kinase 67 5e-10 gi|338228|gb|AAA36615.1| src-like tyrosine kinase (put.); putative 67 5e-10 gi|37182866|gb|AAQ89233.1| LRRC5 [Homo sapiens] 67 5e-10 gi|23241685|gb|AAH34988.1| ULK2 protein [Homo sapiens] 67 5e-10 gi|22760350|dbj|BAC11161.1| unnamed protein product [Homo sapiens] 67 5e-10 gi|55663684|emb|CAH72226.1| leucine rich repeat containing 5 [Ho... 67 5e-10 gi|7022525|dbj|BAA91631.1| unnamed protein product [Homo sapiens] 67 5e-10 gi|40788306|dbj|BAA31598.2| KIAA0623 protein [Homo sapiens] 67 5e-10 gi|23199985|ref|NP_055498.2| unc-51-like kinase 2 [Homo sapiens] 67 5e-10 gi|4758700|ref|NP_004626.1| mitogen-activated protein kinase-act... 67 5e-10 gi|52545731|emb|CAH56273.1| hypothetical protein [Homo sapiens] 67 5e-10 gi|52545685|emb|CAH56285.1| hypothetical protein [Homo sapiens] 67 5e-10 gi|9247171|gb|AAB33113.2| tyrosine kinase p59fyn(T) [Homo sapiens] 67 5e-10 gi|5688866|dbj|BAA82709.1| Aik2 [Homo sapiens] 67 5e-10 gi|29029632|ref|NP_004295.2| anaplastic lymphoma kinase Ki-1 [Ho... 66 7e-10 gi|14042212|dbj|BAB55153.1| unnamed protein product [Homo sapiens] 66 7e-10 gi|13186236|ref|NP_075594.1| fibroblast growth factor receptor 1... 66 7e-10 gi|37181692|gb|AAQ88653.1| RQTI221 [Homo sapiens] >gi|39930379|r... 66 7e-10 gi|11276087|ref|NP_000595.1| fibroblast growth factor receptor 1... 66 7e-10 gi|31368|emb|CAA36101.1| unnamed protein product [Homo sapiens] 66 7e-10 gi|179415|gb|AAA75007.1| basic fibroblast growth factor receptor... 66 7e-10 gi|13186251|ref|NP_056934.2| fibroblast growth factor receptor 1... 66 7e-10 gi|182534|gb|AAA35837.1| fibroblast growth factor receptor (FGFr... 66 7e-10 gi|13186234|ref|NP_075593.1| fibroblast growth factor receptor 1... 66 7e-10 gi|37181710|gb|AAQ88662.1| SAPS287 [Homo sapiens] 66 7e-10 gi|30410930|gb|AAH51322.1| LRRC8 protein [Homo sapiens] >gi|2746... 66 7e-10 gi|38197155|gb|AAH00442.2| AURKB protein [Homo sapiens] 66 7e-10 gi|21955340|gb|AAH15035.1| FGFR1 protein [Homo sapiens] 66 7e-10 gi|17939640|gb|AAH19334.1| Serine/threonine protein kinase 11 [H... 66 7e-10 gi|54695938|gb|AAV38341.1| serine/threonine kinase 12 [Homo sapi... 66 7e-10 gi|20269390|gb|AAM17922.1| TRK-fused gene/anaplastic large cell ... 66 7e-10 gi|22450878|gb|AAH18128.1| Fibroblast growth factor receptor 1, ... 66 7e-10 gi|609342|gb|AAA58698.1| nucleophosmin-anaplastic lymphoma kinas... 66 7e-10 gi|2454168|gb|AAB71619.1| anaplastic lymphoma kinase [Homo sapie... 66 7e-10 gi|182530|gb|AAA35835.1| FGF receptor-1 precursor [Homo sapiens] 66 7e-10 gi|7229261|gb|AAF42734.1| TRK-fused gene-anaplastic lymphoma kin... 66 7e-10 gi|6739535|gb|AAF27292.1| TRK-fused gene/anaplastic lymphoma kin... 66 7e-10 gi|6467479|gb|AAF13156.1| double stranded RNA activated protein ... 66 7e-10 gi|1848244|gb|AAC51104.1| anaplastic lymphoma kinase receptor 66 7e-10 gi|10441887|gb|AAG17221.1| unknown [Homo sapiens] 66 7e-10 gi|38492661|pdb|1OL7|A Chain A, Structure Of Human Aurora-A 122-... 66 7e-10 gi|38492660|pdb|1OL6|A Chain A, Structure Of Unphosphorylated D2... 66 7e-10 gi|6137569|pdb|2FGI|B Chain B, Crystal Structure Of The Tyrosine... 66 7e-10 gi|1483131|dbj|BAA08343.1| p80 protein [Homo sapiens] 66 7e-10 gi|7243272|dbj|BAA92675.1| KIAA1437 protein [Homo sapiens] 66 7e-10 gi|183879|gb|AAA35958.1| heparin-binding growth factor receptor 66 7e-10 gi|558584|emb|CAA68679.1| tyrosine kinase [Homo sapiens] 66 7e-10 gi|107565|pir||S24066 protein-tyrosine kinase (EC 2.7.1.112), re... 66 9e-10 gi|7662320|ref|NP_055628.1| leucine-rich repeats and immunoglobu... 66 9e-10 gi|40788371|dbj|BAA34526.2| KIAA0806 protein [Homo sapiens] 66 9e-10 gi|15131540|emb|CAC48387.1| serine/threonine protein kinase [Hom... 65 1e-09 gi|631291|pir||S39793 MAPK-activated protein kinase 2 (EC 2.7.1.... 65 1e-09 gi|182565|gb|AAA58470.1| growth factor receptor 65 1e-09 gi|53689008|gb|AAU89726.1| fibroblast growth factor receptor 3 (... 65 1e-09 gi|2306915|gb|AAB65786.1| protein kinase [Homo sapiens] 65 1e-09 gi|20452381|gb|AAM22079.1| fibroblast growth factor receptor 3 [... 65 1e-09 gi|20452380|gb|AAM22078.1| fibroblast growth factor receptor 3 [... 65 1e-09 gi|21619202|gb|AAH32726.1| Doublecortin and CaM kinase-like 2 [H... 65 1e-09 gi|34365793|ref|NP_115763.2| WNK lysine deficient protein kinase... 65 1e-09 gi|13112048|ref|NP_075254.1| fibroblast growth factor receptor 3... 65 1e-09 gi|4104411|gb|AAD02030.1| Eph-like receptor tyrosine kinase hEph... 65 1e-09 gi|4090841|gb|AAC98891.1| serine/threonine kinase [Homo sapiens] 65 1e-09 gi|2739208|gb|AAB94627.1| Eph-like receptor tyrosine kinase hEph... 65 1e-09 gi|21740293|emb|CAD39156.1| hypothetical protein [Homo sapiens] 65 1e-09 gi|59797954|sp|Q8N568|DCAK2_HUMAN Serine/threonine-protein kinas... 65 1e-09 gi|56204147|emb|CAI22320.1| lymphocyte-specific protein tyrosine... 65 2e-09 gi|66786|pir||OKHULK protein-tyrosine kinase (EC 2.7.1.112) lck ... 65 2e-09 gi|49457414|emb|CAG47006.1| STK17B [Homo sapiens] 65 2e-09 gi|50960723|gb|AAH75001.1| V-yes-1 Yamaguchi sarcoma viral relat... 65 2e-09 gi|187271|gb|AAB50019.1| Lyn B protein [Homo sapiens] >gi|741028... 65 2e-09 gi|28372413|gb|AAO38055.1| protein kinase, interferon-inducible ... 65 2e-09 gi|37589566|gb|AAH59394.1| LYN protein [Homo sapiens] >gi|462500... 65 2e-09 gi|31747519|gb|AAP57628.1| interferon-inducible double-stranded ... 65 2e-09 gi|5139790|dbj|BAA81737.1| atrial natriuretic peptide Btype rece... 65 2e-09 gi|20428652|ref|NP_005347.2| lymphocyte-specific protein tyrosin... 65 2e-09 gi|187034|gb|AAA59502.1| lymphocyte-specific protein tyrosine ki... 65 2e-09 gi|476555|pir||TVHU2F fibroblast growth factor receptor flg-2 pr... 65 2e-09 gi|10441883|gb|AAG17219.1| unknown [Homo sapiens] 65 2e-09 gi|1000127|gb|AAC50209.1| PRK1 >gi|6174910|sp|Q16512|PKL1_HUMAN ... 65 2e-09 gi|23398605|gb|AAH38239.1| Tyrosine kinase with immunoglobulin-l... 65 2e-09 gi|55859715|emb|CAI10986.1| natriuretic peptide receptor B\/guan... 65 2e-09 gi|4506101|ref|NP_002748.1| mitogen-activated protein kinase kin... 65 2e-09 gi|284146|pir||A38224 protein-tyrosine kinase (EC 2.7.1.112) hek... 65 2e-09 gi|47132589|ref|NP_002732.3| protein kinase N1 isoform 2 [Homo s... 65 2e-09 gi|13559171|emb|CAC36078.1| C447E6.2 (insulin-like growth factor... 65 2e-09 gi|15030037|gb|AAH11263.1| Mitogen-activated protein kinase kina... 65 2e-09 gi|55859716|emb|CAI10987.1| OTTHUMP00000045390 [Homo sapiens] >g... 65 2e-09 gi|30039692|ref|NP_835464.1| NIMA-related kinase 8 [Homo sapiens... 65 2e-09 gi|45181421|gb|AAS55390.1| dusty protein kinase [Homo sapiens] >... 65 2e-09 gi|47132591|ref|NP_998725.1| protein kinase N1 isoform 1 [Homo s... 65 2e-09 gi|21729897|ref|NP_660144.1| mitogen-activated protein kinase ki... 65 2e-09 gi|56204241|emb|CAI23386.1| tyrosine kinase with immunoglobulin ... 65 2e-09 gi|48734889|gb|AAH72406.1| Receptor interacting protein kinase 5... 65 2e-09 gi|40806179|ref|NP_056190.1| receptor interacting protein kinase... 65 2e-09 gi|25304069|gb|AAH40061.1| Protein kinase C-like 1, isoform 2 [H... 65 2e-09 gi|40353033|gb|AAH64543.1| Mitogen-activated protein kinase kina... 65 2e-09 gi|18606407|gb|AAH23017.1| Similar to natriuretic peptide recept... 65 2e-09 gi|19344010|gb|AAH25681.1| Insulin-like growth factor binding pr... 65 2e-09 gi|36808|emb|CAA28691.1| unnamed protein product [Homo sapiens] 65 2e-09 gi|1616781|gb|AAB16852.1| MAP kinase kinase MEK5c [Homo sapiens] 65 2e-09 gi|8569441|pdb|1QPD|A Chain A, Structural Analysis Of The Lympho... 65 2e-09 gi|3413906|dbj|BAA32317.1| KIAA0472 protein [Homo sapiens] 65 2e-09 gi|1093486|prf||2104208A protein kinase C-related kinase:ISOTYPE... 65 2e-09 gi|54607118|ref|NP_056356.2| leucine-rich repeats and immunoglob... 64 3e-09 gi|22713539|gb|AAH37166.1| Ephrin receptor EphA2 [Homo sapiens] ... 64 3e-09 gi|107496|pir||A36355 protein-tyrosine kinase (EC 2.7.1.112) eck... 64 3e-09 gi|38648757|gb|AAH63282.1| EPHA3 protein [Homo sapiens] 64 3e-09 gi|14423349|gb|AAK62357.1| membrane glycoprotein LRIG1 [Homo sap... 64 3e-09 gi|2781151|pdb|3LCK| The Kinase Domain Of Human Lymphocyte Kina... 64 3e-09 gi|4507831|ref|NP_003556.1| unc-51-like kinase 1 [Homo sapiens] ... 64 3e-09 gi|21361241|ref|NP_005224.2| ephrin receptor EphA3 isoform a pre... 64 3e-09 gi|48734697|gb|AAH71561.1| LRIG1 protein [Homo sapiens] 64 3e-09 gi|37926808|pdb|1MQB|B Chain B, Crystal Structure Of Ephrin A2 (... 64 3e-09 gi|8569366|pdb|1QPJ|A Chain A, Crystal Structure Of The Lymphocy... 64 3e-09 gi|13537355|dbj|BAB40659.1| membrane glycoprotein LIG-1 [Homo sa... 64 3e-09 gi|20521139|dbj|BAA34442.2| KIAA0722 protein [Homo sapiens] 64 3e-09 gi|42544153|ref|NP_002335.2| leukocyte tyrosine kinase isoform 1... 64 3e-09 gi|22652263|gb|AAN03661.1| novel kinase [Homo sapiens] >gi|20380... 64 3e-09 gi|34420|emb|CAA43113.1| tyrosine kinase [Homo sapiens] 64 3e-09 gi|52355222|gb|AAU44786.1| leucine-rich repeat protein LRIG1 [Ho... 64 3e-09 gi|11056008|ref|NP_067647.1| leucine-rich repeat-containing G pr... 64 3e-09 gi|55959024|emb|CAI15927.1| leucine-rich repeat-containing G pro... 64 3e-09 gi|46249416|ref|NP_996844.1| leukocyte tyrosine kinase isoform 2... 64 3e-09 gi|440855|dbj|BAA03679.1| leukocyte tyrosine kinase [Homo sapien... 64 3e-09 gi|13447610|dbj|BAB39854.1| VTS20631 [Homo sapiens] 64 3e-09 gi|23512307|gb|AAH38448.1| TESK1 protein [Homo sapiens] >gi|5595... 64 4e-09 gi|5454110|ref|NP_006276.1| testis-specific protein kinase 1 [Ho... 64 4e-09 gi|28950596|emb|CAD70625.1| RIPK1 [Homo sapiens] >gi|57242761|re... 64 4e-09 gi|6466010|gb|AAF12758.1| protein kinase [Homo sapiens] >gi|4916... 64 4e-09 gi|52078442|gb|AAH82244.1| PLEKHE1 protein [Homo sapiens] 64 4e-09 gi|7513330|pir||T09479 serine/threonine protein kinase (EC 2.7.1... 64 4e-09 gi|57999525|emb|CAI45969.1| hypothetical protein [Homo sapiens] 64 4e-09 gi|31563382|ref|NP_037389.4| serum/glucocorticoid regulated kina... 64 4e-09 gi|38492557|pdb|1NXK|D Chain D, Crystal Structure Of Staurospori... 64 4e-09 gi|10862701|ref|NP_065681.1| ret proto-oncogene isoform c [Homo ... 63 6e-09 gi|13186243|ref|NP_075418.1| fibroblast growth factor receptor 2... 63 6e-09 gi|13186261|ref|NP_075262.1| fibroblast growth factor receptor 2... 63 6e-09 gi|55953117|ref|NP_003943.2| ribosomal protein S6 kinase, 70kDa,... 63 6e-09 gi|38275|emb|CAA31408.1| unnamed protein product [Homo sapiens] 63 6e-09 gi|10862703|ref|NP_066124.1| ret proto-oncogene isoform a [Homo ... 63 6e-09 gi|55962535|emb|CAI17115.1| protein kinase, cGMP-dependent, type... 63 6e-09 gi|13186263|ref|NP_075263.1| fibroblast growth factor receptor 2... 63 6e-09 gi|13186259|ref|NP_075261.1| fibroblast growth factor receptor 2... 63 6e-09 gi|13186255|ref|NP_075259.1| fibroblast growth factor receptor 2... 63 6e-09 gi|4503709|ref|NP_000132.1| fibroblast growth factor receptor 2 ... 63 6e-09 gi|13186253|ref|NP_075258.1| fibroblast growth factor receptor 2... 63 6e-09 gi|106231|pir||A35969 heparin-binding growth factor receptor K-s... 63 6e-09 gi|6382062|ref|NP_009298.1| v-abl Abelson murine leukemia viral ... 63 6e-09 gi|423137|pir||S33596 protein-tyrosine kinase (EC 2.7.1.112) - h... 63 6e-09 gi|32165606|gb|AAP72030.1| cardiac ankyrin repeat kinase [Homo s... 63 6e-09 gi|25058745|gb|AAH39243.1| FGFR2 protein [Homo sapiens] 63 6e-09 gi|21620011|gb|AAH33085.1| TESK2 protein [Homo sapiens] 63 6e-09 gi|56611113|gb|AAH00094.3| Ribosomal protein S6 kinase, 70kDa, p... 63 6e-09 gi|13186269|ref|NP_075417.1| fibroblast growth factor receptor 2... 63 6e-09 gi|6382060|ref|NP_005149.2| v-abl Abelson murine leukemia viral ... 63 6e-09 gi|3882085|dbj|BAA34402.1| p70 ribosomal S6 kinase beta [Homo sa... 63 6e-09 gi|22325362|ref|NP_665894.1| leucine rich repeat and death domai... 63 6e-09 gi|55962534|emb|CAI17114.1| protein kinase, cGMP-dependent, type... 63 6e-09 gi|57209582|emb|CAI40744.1| protein kinase, cGMP-dependent, type... 63 6e-09 gi|56205993|emb|CAI21723.1| testis-specific kinase 2 [Homo sapie... 63 6e-09 gi|55959049|emb|CAI15584.1| v-abl Abelson murine leukemia viral ... 63 6e-09 gi|56611111|gb|AAH06106.3| Ribosomal protein S6 kinase, 70kDa, p... 63 6e-09 gi|22325360|ref|NP_665893.1| leucine rich repeat and death domai... 63 6e-09 gi|27754769|ref|NP_075264.2| fibroblast growth factor receptor 2... 63 6e-09 gi|15281418|gb|AAK94209.1| keratinocyte growth factor receptor 2... 63 6e-09 gi|15281417|gb|AAK94208.1| keratinocyte growth factor receptor 2... 63 6e-09 gi|15281415|gb|AAK94206.1| keratinocyte growth factor receptor 2... 63 6e-09 gi|15281414|gb|AAK94205.1| keratinocyte growth factor receptor 2... 63 6e-09 gi|3063840|emb|CAB07436.1| cGMP-dependent protein kinase type I ... 63 6e-09 gi|31874804|emb|CAD98092.1| hypothetical protein [Homo sapiens] 63 6e-09 gi|27260913|dbj|BAC45037.1| isoform of FGFR2 [Homo sapiens] 63 6e-09 gi|20380414|gb|AAH28164.1| TNK2 protein [Homo sapiens] 63 6e-09 gi|56549666|ref|NP_005772.3| tyrosine kinase, non-receptor, 2 is... 63 6e-09 gi|58331191|ref|NP_001010938.1| tyrosine kinase, non-receptor, 2... 63 6e-09 gi|4883534|gb|AAD31561.1| fibroblast growth factor receptor 2 is... 63 6e-09 gi|4883533|gb|AAD31560.1| fibroblast growth receptor 2 IgIIIb is... 63 6e-09 gi|88517|pir||JN0290 protein-tyrosine kinase (EC 2.7.1.112) (clo... 63 6e-09 gi|2135241|pir||I38153 gene retII protein - human >gi|36009|emb|... 63 6e-09 gi|420088|pir||B34735 protein-tyrosine kinase (EC 2.7.1.112) (re... 63 6e-09 gi|88518|pir||JN0291 protein-tyrosine kinase (EC 2.7.1.112) (clo... 63 6e-09 gi|7434394|pir||JE0377 p70 S6 kinase (EC 2.7.-.-) - human >gi|41... 63 6e-09 gi|42406387|gb|AAH65912.1| ABL2 protein [Homo sapiens] 63 6e-09 gi|47077584|dbj|BAD18675.1| unnamed protein product [Homo sapiens] 63 6e-09 gi|37999491|sp|Q07912|ACK1_HUMAN Activated CDC42 kinase 1 (ACK-1... 63 6e-09 gi|22218646|pdb|1GJO|A Chain A, The Fgfr2 Tyrosine Kinase Domain... 63 6e-09 gi|52696005|pdb|1U54|B Chain B, Crystal Structures Of The Phosph... 63 6e-09 gi|52696004|pdb|1U54|A Chain A, Crystal Structures Of The Phosph... 63 6e-09 gi|190700|gb|AAA36524.1| papillary thyroid carcinoma-encoded pro... 63 6e-09 gi|285917|dbj|BAA03537.1| large erk kinase [Homo sapiens] 63 8e-09 gi|337358|gb|AAA60266.1| RET tyrosine kinase/cAMP protein kinase... 63 8e-09 gi|1100110|gb|AAA99310.1| protein-tyrosine kinase >gi|1585220|pr... 63 8e-09 gi|56205037|emb|CAI22899.1| EPH receptor B2 [Homo sapiens] >gi|5... 63 8e-09 gi|56205036|emb|CAI22898.1| EPH receptor B2 [Homo sapiens] >gi|5... 63 8e-09 gi|56205035|emb|CAI22897.1| EPH receptor B2 [Homo sapiens] >gi|5... 63 8e-09 gi|56202939|emb|CAI22644.1| EPH receptor B2 [Homo sapiens] >gi|5... 63 8e-09 gi|21389162|gb|AAM50515.1| testis-specific kinase-1 [Homo sapiens] 63 8e-09 gi|495678|dbj|BAA06506.1| tyrosine kinase precursor [Homo sapiens] 63 8e-09 gi|2136054|pir||A57174 protein-tyrosine kinase (EC 2.7.1.112) er... 63 8e-09 gi|7434435|pir||I78842 receptor protein-tyrosine kinase - human ... 63 8e-09 gi|12644190|sp|P29323|EPHB2_HUMAN Ephrin type-B receptor 2 precu... 63 8e-09 gi|7546569|pdb|1VR2|A Chain A, Human Vascular Endothelial Growth... 63 8e-09 gi|340026|gb|AAA36786.1| tyrosine kinase 63 8e-09 gi|21752067|dbj|BAC04109.1| unnamed protein product [Homo sapien... 62 1e-08 gi|599827|emb|CAA56515.1| serine/threonine protein kinase [Homo ... 62 1e-08 gi|15341997|gb|AAH13200.1| LCK protein [Homo sapiens] 62 1e-08 gi|482917|emb|CAA81796.1| receptor tyrosine kinase eph [Homo sap... 62 1e-08 gi|41472551|gb|AAS07458.1| unknown [Homo sapiens] 62 1e-08 gi|4507531|ref|NP_003256.1| toll-like receptor 3 [Homo sapiens] ... 62 1e-08 gi|9845487|ref|NP_059672.1| MAP/microtubule affinity-regulating ... 62 1e-08 gi|37590301|gb|AAH59372.1| TLR3 protein [Homo sapiens] 62 1e-08 gi|37181344|gb|AAQ88486.1| gonadotropin receptor [Homo sapiens] ... 62 1e-08 gi|34782791|gb|AAH08771.2| MARK2 protein [Homo sapiens] 62 1e-08 gi|51094534|gb|EAL23789.1| EphA1 [Homo sapiens] >gi|47117832|sp|... 62 1e-08 gi|55777408|gb|AAH47905.2| Leucine-rich repeat-containing G prot... 62 1e-08 gi|30583523|gb|AAP36006.1| MAP/microtubule affinity-regulating k... 62 1e-08 gi|54261525|gb|AAH84540.1| MARK2 protein [Homo sapiens] 62 1e-08 gi|56204148|emb|CAI22321.1| lymphocyte-specific protein tyrosine... 62 1e-08 gi|45220438|dbj|BAD12234.1| unnamed protein product [Homo sapiens] 62 1e-08 gi|7020356|dbj|BAA91094.1| unnamed protein product [Homo sapiens] 62 1e-08 gi|56119207|ref|NP_005223.3| ephrin receptor EphA1 [Homo sapiens] 62 1e-08 gi|7705841|ref|NP_057207.1| interleukin-1 receptor-associated ki... 62 1e-08 gi|9845489|ref|NP_004945.2| MAP/microtubule affinity-regulating ... 62 1e-08 gi|22658392|gb|AAH31231.1| Serine/threonine kinase 33 [Homo sapi... 62 1e-08 gi|15042611|gb|AAK82368.1| Ser/Thr protein kinase PAR-1Balpha [H... 62 1e-08 gi|17402861|gb|AAF27051.2| SGK-like protein SGKL [Homo sapiens] 62 1e-08 gi|87779|pir||A34076 protein-tyrosine kinase (EC 2.7.1.112) rece... 62 1e-08 gi|5453122|gb|AAD43440.1| receptor tyrosine kinase [Homo sapiens] 62 1e-08 gi|7446398|pir||G01025 serine/threonine protein kinase - human 62 1e-08 gi|51534926|dbj|BAD37141.1| serine/threonine kinase [Homo sapiens] 62 1e-08 gi|6691445|dbj|BAA89296.1| K-sam-IIH1 [Homo sapiens] 62 1e-08 gi|3135309|gb|AAC78793.1| leucin rich neuronal protein [Homo sap... 62 1e-08 gi|16552748|dbj|BAB71371.1| unnamed protein product [Homo sapien... 62 1e-08 gi|55958961|emb|CAI13114.1| serine\/threonine kinase 24 (STE20 h... 62 1e-08 gi|23274191|gb|AAH35578.1| STK24 protein [Homo sapiens] >gi|5469... 62 1e-08 gi|55957943|emb|CAC12904.2| protein kinase C, theta [Homo sapien... 62 1e-08 gi|1082565|pir||A55747 L-JAK protein-tyrosine kinase - human >gi... 62 1e-08 gi|30181233|ref|NP_002310.2| leucine-rich repeats and calponin h... 62 1e-08 gi|2582413|gb|AAB82560.1| STE20-like kinase 3 [Homo sapiens] 62 1e-08 gi|558099|gb|AAA75571.1| protein kinase C-theta 62 1e-08 gi|55958960|emb|CAI13113.1| serine\/threonine kinase 24 (STE20 h... 62 1e-08 gi|55957944|emb|CAI16128.1| OTTHUMP00000043365 [Homo sapiens] >g... 62 1e-08 gi|55957942|emb|CAI16127.1| OTTHUMP00000043364 [Homo sapiens] >g... 62 1e-08 gi|4503687|ref|NP_001996.1| V-FES feline sarcoma viral/V-FPS fuj... 62 1e-08 gi|39962915|gb|AAH64422.1| PNCK protein [Homo sapiens] 62 1e-08 gi|13279041|gb|AAH04257.1| Ret proto-oncogene, isoform c [Homo s... 62 1e-08 gi|3132526|gb|AAC34376.1| Toll/interleukin-1 receptor-like prote... 62 1e-08 gi|280850|pir||A43625 protein-tyrosine kinase (EC 2.7.1.112) ltk... 62 1e-08 gi|41107636|gb|AAH65378.1| STK24 protein [Homo sapiens] 62 1e-08 gi|20140433|sp|O60602|TLR5_HUMAN Toll-like receptor 5 precursor ... 62 1e-08 gi|49456921|emb|CAG46781.1| RAB6A [Homo sapiens] 62 1e-08 gi|56554577|pdb|1XJD|A Chain A, Crystal Structure Of Pkc-Theta C... 62 1e-08 gi|13960149|gb|AAH07514.1| ARAF1 protein [Homo sapiens] 62 2e-08 gi|4680397|emb|CAB41303.1| guanylate cyclase 2F, retinal [Homo s... 62 2e-08 gi|5139484|emb|CAB45657.1| OTTHUMP00000028888 [Homo sapiens] 62 2e-08 gi|9837341|gb|AAG00534.1| CamKI-like protein kinase [Homo sapien... 62 2e-08 gi|1340152|emb|CAA28476.1| unnamed protein product [Homo sapiens] 62 2e-08 gi|4504219|ref|NP_001513.1| guanylate cyclase 2F [Homo sapiens] ... 62 2e-08 gi|30582399|gb|AAP35426.1| mitogen-activated protein kinase kina... 62 2e-08 gi|54696590|gb|AAV38667.1| v-raf murine sarcoma 3611 viral oncog... 62 2e-08 gi|4885231|ref|NP_005237.1| fer (fps/fes related) tyrosine kinas... 62 2e-08 gi|54696264|gb|AAV38504.1| RAB6A, member RAS oncogene family [Ho... 62 2e-08 gi|27805738|sp|Q9UQB9|AURKC_HUMAN Serine/threonine-protein kinas... 62 2e-08 gi|88515|pir||B26368 protein-serine kinase (EC 2.7.1.-) PSK-H1 -... 62 2e-08 gi|55962537|emb|CAI14675.1| OTTHUMP00000045030 [Homo sapiens] >g... 62 2e-08 gi|22477868|gb|AAH36797.1| ADRBK2 protein [Homo sapiens] 62 2e-08 gi|51471708|gb|AAU04399.1| aurora-C [Homo sapiens] 62 2e-08 gi|55957675|emb|CAI12893.1| OTTHUMP00000040896 [Homo sapiens] >g... 62 2e-08 gi|7263928|emb|CAB81612.1| EPH receptor A8 [Homo sapiens] >gi|10... 62 2e-08 gi|13161938|emb|CAC32991.1| putative protein kinase WNK4 [Homo s... 62 2e-08 gi|50959740|gb|AAH75064.1| Unknown (protein for IMAGE:30915373) ... 62 2e-08 gi|21729899|ref|NP_660145.1| mitogen-activated protein kinase ki... 62 2e-08 gi|49338210|gb|AAT64422.1| aurora/Ipl1-related kinase 3 transcri... 62 2e-08 gi|3298603|gb|AAC25955.1| serine/threonine kinase AIE2 [Homo sap... 62 2e-08 gi|7959179|dbj|BAA95983.1| KIAA1459 protein [Homo sapiens] 62 2e-08 gi|13186249|ref|NP_075599.1| fibroblast growth factor receptor 1... 61 2e-08 gi|345763|pir||JC1469 beta-adrenergic-receptor kinase (EC 2.7.1.... 61 2e-08 gi|26667199|ref|NP_751910.1| calcium/calmodulin-dependent protei... 61 2e-08 gi|21263106|gb|AAM44860.1| Janus kinase 3 (a protein tyrosine ki... 61 2e-08 gi|387023|gb|AAB08754.1| raf related protein [Homo sapiens] 61 2e-08 gi|55665674|emb|CAH73650.1| EPHA7 [Homo sapiens] >gi|56203500|em... 61 2e-08 gi|30583365|gb|AAP35927.1| RAB6B, member RAS oncogene family [Ho... 61 2e-08 gi|55961895|emb|CAI13789.1| calcium\/calmodulin-dependent protei... 61 2e-08 gi|55961897|emb|CAI13791.1| calcium\/calmodulin-dependent protei... 61 2e-08 gi|4758696|ref|NP_004712.1| mitogen-activated protein kinase kin... 61 2e-08 gi|26667211|ref|NP_751913.1| calcium/calmodulin-dependent protei... 61 2e-08 gi|26667206|ref|NP_751912.1| calcium/calmodulin-dependent protei... 61 2e-08 gi|55961894|emb|CAI13788.1| calcium\/calmodulin-dependent protei... 61 2e-08 gi|284367|pir||S27966 probable serine/threonine-specific protein... 61 2e-08 gi|55961896|emb|CAI13790.1| calcium\/calmodulin-dependent protei... 61 2e-08 gi|55961893|emb|CAI13787.1| calcium\/calmodulin-dependent protei... 61 2e-08 gi|21039158|gb|AAM33514.1| calcium/calmodulin-dependent protein ... 61 2e-08 gi|26667203|ref|NP_751911.1| calcium/calmodulin-dependent protei... 61 2e-08 gi|4885055|ref|NP_005151.1| beta adrenergic receptor kinase 2 [H... 61 2e-08 gi|3089349|gb|AAC15093.1| Cdc25C associated protein kinase C-TAK... 61 2e-08 gi|19353236|gb|AAH24773.1| MAP/microtubule affinity-regulating k... 61 2e-08 gi|21707842|gb|AAH34044.1| Calcium/calmodulin-dependent protein ... 61 2e-08 gi|15042609|gb|AAK82367.1| Ser/Thr protein kinase PAR-1A [Homo s... 61 2e-08 gi|1800225|gb|AAC50950.1| JAK3 [Homo sapiens] 61 2e-08 gi|46852166|ref|NP_002367.4| MAP/microtubule affinity-regulating... 61 2e-08 gi|2511440|gb|AAB80848.1| calcium/calmodulin-dependent protein k... 61 2e-08 gi|2204281|gb|AAB61379.1| calcium/calmodulin-dependent protein k... 61 2e-08 gi|20178304|sp|Q13555|KCC2G_HUMAN Calcium/calmodulin-dependent p... 61 2e-08 gi|18448971|gb|AAL69982.1| MAP/microtubule affinity-regulating k... 61 2e-08 gi|6088096|dbj|BAA85625.1| protein kinase PKNbeta [Homo sapiens] 61 2e-08 gi|37545085|ref|XP_292678.2| PREDICTED: similar to RIKEN cDNA 26... 61 3e-08 gi|10440103|dbj|BAB15648.1| unnamed protein product [Homo sapiens] 61 3e-08 gi|11321597|ref|NP_002244.1| kinase insert domain receptor (a ty... 61 3e-08 gi|7662102|ref|NP_056379.1| leucine rich repeat transmembrane ne... 61 3e-08 gi|31718|emb|CAA43837.1| membrane protein [Homo sapiens] >gi|186... 61 3e-08 gi|56205994|emb|CAI21724.1| testis-specific kinase 2 [Homo sapie... 61 3e-08 gi|16741621|gb|AAH16615.1| RAB37, member RAS oncogene family [Ho... 61 3e-08 gi|400127|sp|P07332|FES_HUMAN Proto-oncogene tyrosine-protein ki... 61 3e-08 gi|55957674|emb|CAI12892.1| OTTHUMP00000018442 [Homo sapiens] 61 3e-08 gi|57997199|emb|CAI46210.1| hypothetical protein [Homo sapiens] 61 3e-08 gi|3127068|gb|AAC77369.1| serine/threonine kinase 13 [Homo sapie... 61 3e-08 gi|6005896|ref|NP_009101.1| testis-specific protein kinase 2 [Ho... 61 3e-08 gi|40788250|dbj|BAA24846.2| KIAA0416 [Homo sapiens] 61 3e-08 gi|3132833|gb|AAC16450.1| vascular endothelial growth factor rec... 61 3e-08 gi|40217803|ref|NP_079337.2| hypothetical protein FLJ23420 [Homo... 61 3e-08 gi|47125302|gb|AAH70089.1| Hypothetical protein FLJ23420 [Homo s... 61 3e-08 gi|7446386|pir||JC1402 protein-tyrosine kinase (EC 2.7.1.112) KD... 61 3e-08 gi|45946091|gb|AAH22216.2| FLJ23420 protein [Homo sapiens] 61 3e-08 gi|21740244|emb|CAD39133.1| hypothetical protein [Homo sapiens] 61 3e-08 gi|56203813|emb|CAI23379.1| v-ros UR2 sarcoma virus oncogene hom... 60 4e-08 gi|56203812|emb|CAI23378.1| OTTHUMP00000040389 [Homo sapiens] >g... 60 4e-08 ALIGNMENTS >gi|55740398|gb|AAV63975.1| leucine-rich repeat kinase 2 [Homo sapiens] Length = 2527 Score = 3303 bits (8564), Expect = 0.0 Identities = 1767/2265 (78%), Positives = 1831/2265 (80%), Gaps = 274/2265 (12%) Query: 105 VGNDWEVL---GVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILD------- 154 +GN + +L VH+ ++K + + + L + L L LL + + + + Sbjct: 279 LGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQEN 338 Query: 155 ----EESDIFML--IFDAMHSFPANDEVQKLGCKALHVLFERGNNVEVLMS---GNVRCY 205 EE +F L + A+ N VQ+ C AL+ L N++ + G+ + Sbjct: 339 DDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAH 398 Query: 206 NIVVEAMKAFPMSERIQEVSCCLLHRLTLGN--FFNILVLNEVHEFVVKAVQQYPENAAL 263 V+ +M S+ + + S L L N F IL+ +H V++ +Q++ + Sbjct: 399 REVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSP-- 456 Query: 264 QISALSCLALLRSFPGICECIVNSLRTKCNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 323 +++ C L F G NTSLDIMAAVVPKILTVMKRHETSLPVQLEA Sbjct: 457 EVAESGCKMLNHLFEG------------SNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 504 Query: 324 LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 383 LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL Sbjct: 505 LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 564 Query: 384 KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 443 KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG Sbjct: 565 KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 624 Query: 444 HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 503 HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM Sbjct: 625 HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 684 Query: 504 EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 563 EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL Sbjct: 685 EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 744 Query: 564 ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 623 ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC Sbjct: 745 ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 804 Query: 624 LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 683 LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF Sbjct: 805 LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 864 Query: 684 SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 743 SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR Sbjct: 865 SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 924 Query: 744 CSPNLQRHSNSL---------------------TLKSLTHLDLHSNKFTSFPSYLLKMSC 782 CSPNLQRHSNSL +L+S + L H S S + Sbjct: 925 CSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRS-SKLQSHMRHSDSISSLASEREY 983 Query: 783 IANLDVSRNDIGPSVVLDP----TVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILE 838 I +LD+S N++ L +V L++ L N L+ P+ L + ++ L L L Sbjct: 984 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 1043 Query: 839 GNKISGICSPL--------------------------RLKELKILNLSKNHISSLSEN-- 870 NK + S L + LK NLS N +S + EN Sbjct: 1044 SNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLT 1103 Query: 871 --------------------------------------------FLEACPKVESFSARMN 886 FLEACPKVESFSARMN Sbjct: 1104 DVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMN 1163 Query: 887 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR Sbjct: 1164 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 1223 Query: 947 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS Sbjct: 1224 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1283 Query: 1007 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1066 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT Sbjct: 1284 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1343 Query: 1067 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1126 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS Sbjct: 1344 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1403 Query: 1127 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1186 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK Sbjct: 1404 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1463 Query: 1187 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1246 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI Sbjct: 1464 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1523 Query: 1247 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES---- 1302 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES Sbjct: 1524 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLL 1583 Query: 1303 -----------------------------VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1333 VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK Sbjct: 1584 HFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1643 Query: 1334 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1393 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG Sbjct: 1644 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1703 Query: 1394 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1453 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL Sbjct: 1704 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1763 Query: 1454 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1513 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ Sbjct: 1764 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1823 Query: 1514 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1573 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF Sbjct: 1824 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1883 Query: 1574 LL----------------------------------------------------AGIRPR 1581 LL AGIRPR Sbjct: 1884 LLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPR 1943 Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF Sbjct: 1944 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 2003 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL Sbjct: 2004 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 2063 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP Sbjct: 2064 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 2123 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 1821 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD Sbjct: 2124 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 2183 Query: 1822 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 1881 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD Sbjct: 2184 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 2243 Query: 1882 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 1941 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL Sbjct: 2244 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 2303 Query: 1942 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2001 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL Sbjct: 2304 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2363 Query: 2002 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLSVIWMVLEGHTVKHK---TGSLKNV----- 2053 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFL + MV E KHK +G +K + Sbjct: 2364 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREV-MVKENKESKHKMSYSGRVKTLCLQKN 2422 Query: 2054 -----------------------------------------------MLVLGYNRKNTEG 2066 MLVLGYNRKNTEG Sbjct: 2423 TALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEG 2482 Query: 2067 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2111 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE Sbjct: 2483 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2527 Score = 512 bits (1318), Expect = e-144 Identities = 272/319 (85%), Positives = 272/319 (85%), Gaps = 45/319 (14%) Query: 1 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI 60 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSE ASKLFQGKNI Sbjct: 1 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI 60 Query: 61 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK Sbjct: 61 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120 Query: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG Sbjct: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180 Query: 181 CKALHVLFER---------------------------------------------GNNVE 195 CKALHVLFER NNVE Sbjct: 181 CKALHVLFERVSEEQLTEFVENKDYMILLSASTNFKDEEEIVLHVLHCLHSLAIPCNNVE 240 Query: 196 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ 255 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ Sbjct: 241 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ 300 Query: 256 QYPENAALQISALSCLALL 274 QYPENAALQISALSCLALL Sbjct: 301 QYPENAALQISALSCLALL 319 >gi|41149741|ref|XP_058513.7| PREDICTED: similar to RIKEN cDNA 4921513O20; cDNA sequence, clone 3-75 [Homo sapiens] Length = 2482 Score = 3303 bits (8564), Expect = 0.0 Identities = 1767/2265 (78%), Positives = 1831/2265 (80%), Gaps = 274/2265 (12%) Query: 105 VGNDWEVL---GVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILD------- 154 +GN + +L VH+ ++K + + + L + L L LL + + + + Sbjct: 234 LGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQEN 293 Query: 155 ----EESDIFML--IFDAMHSFPANDEVQKLGCKALHVLFERGNNVEVLMS---GNVRCY 205 EE +F L + A+ N VQ+ C AL+ L N++ + G+ + Sbjct: 294 DDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAH 353 Query: 206 NIVVEAMKAFPMSERIQEVSCCLLHRLTLGN--FFNILVLNEVHEFVVKAVQQYPENAAL 263 V+ +M S+ + + S L L N F IL+ +H V++ +Q++ + Sbjct: 354 REVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSP-- 411 Query: 264 QISALSCLALLRSFPGICECIVNSLRTKCNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 323 +++ C L F G NTSLDIMAAVVPKILTVMKRHETSLPVQLEA Sbjct: 412 EVAESGCKMLNHLFEG------------SNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 459 Query: 324 LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 383 LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL Sbjct: 460 LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 519 Query: 384 KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 443 KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG Sbjct: 520 KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 579 Query: 444 HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 503 HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM Sbjct: 580 HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 639 Query: 504 EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 563 EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL Sbjct: 640 EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 699 Query: 564 ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 623 ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC Sbjct: 700 ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 759 Query: 624 LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 683 LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF Sbjct: 760 LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 819 Query: 684 SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 743 SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR Sbjct: 820 SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 879 Query: 744 CSPNLQRHSNSL---------------------TLKSLTHLDLHSNKFTSFPSYLLKMSC 782 CSPNLQRHSNSL +L+S + L H S S + Sbjct: 880 CSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRS-SKLQSHMRHSDSISSLASEREY 938 Query: 783 IANLDVSRNDIGPSVVLDP----TVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILE 838 I +LD+S N++ L +V L++ L N L+ P+ L + ++ L L L Sbjct: 939 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 998 Query: 839 GNKISGICSPL--------------------------RLKELKILNLSKNHISSLSEN-- 870 NK + S L + LK NLS N +S + EN Sbjct: 999 SNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLT 1058 Query: 871 --------------------------------------------FLEACPKVESFSARMN 886 FLEACPKVESFSARMN Sbjct: 1059 DVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMN 1118 Query: 887 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR Sbjct: 1119 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 1178 Query: 947 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS Sbjct: 1179 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1238 Query: 1007 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1066 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT Sbjct: 1239 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1298 Query: 1067 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1126 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS Sbjct: 1299 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1358 Query: 1127 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1186 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK Sbjct: 1359 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1418 Query: 1187 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1246 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI Sbjct: 1419 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1478 Query: 1247 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES---- 1302 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES Sbjct: 1479 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLL 1538 Query: 1303 -----------------------------VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1333 VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK Sbjct: 1539 HFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1598 Query: 1334 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1393 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG Sbjct: 1599 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1658 Query: 1394 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1453 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL Sbjct: 1659 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1718 Query: 1454 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1513 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ Sbjct: 1719 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1778 Query: 1514 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1573 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF Sbjct: 1779 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1838 Query: 1574 LL----------------------------------------------------AGIRPR 1581 LL AGIRPR Sbjct: 1839 LLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPR 1898 Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF Sbjct: 1899 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1958 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL Sbjct: 1959 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 2018 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP Sbjct: 2019 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 2078 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 1821 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD Sbjct: 2079 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 2138 Query: 1822 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 1881 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD Sbjct: 2139 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 2198 Query: 1882 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 1941 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL Sbjct: 2199 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 2258 Query: 1942 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2001 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL Sbjct: 2259 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2318 Query: 2002 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLSVIWMVLEGHTVKHK---TGSLKNV----- 2053 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFL + MV E KHK +G +K + Sbjct: 2319 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREV-MVKENKESKHKMSYSGRVKTLCLQKN 2377 Query: 2054 -----------------------------------------------MLVLGYNRKNTEG 2066 MLVLGYNRKNTEG Sbjct: 2378 TALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEG 2437 Query: 2067 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2111 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE Sbjct: 2438 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2482 Score = 539 bits (1388), Expect = e-152 Identities = 274/274 (100%), Positives = 274/274 (100%) Query: 1 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI 60 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI Sbjct: 1 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI 60 Query: 61 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK Sbjct: 61 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120 Query: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG Sbjct: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180 Query: 181 CKALHVLFERGNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNI 240 CKALHVLFERGNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNI Sbjct: 181 CKALHVLFERGNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNI 240 Query: 241 LVLNEVHEFVVKAVQQYPENAALQISALSCLALL 274 LVLNEVHEFVVKAVQQYPENAALQISALSCLALL Sbjct: 241 LVLNEVHEFVVKAVQQYPENAALQISALSCLALL 274 >gi|34534766|dbj|BAC87105.1| unnamed protein product [Homo sapiens] Length = 870 Score = 1132 bits (2928), Expect = 0.0 Identities = 621/845 (73%), Positives = 653/845 (77%), Gaps = 112/845 (13%) Query: 236 NFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLRSFPGICECIVNSLRTKCNTS 295 NF IL+ +H V++ +Q++ + +++ C L F G NTS Sbjct: 30 NFRKILLSKGIHLNVLELMQKHIHSP--EVAESGCKMLNHLFEG------------SNTS 75 Query: 296 LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQ 355 LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQ Sbjct: 76 LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQ 135 Query: 356 CFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY 415 CFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY Sbjct: 136 CFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY 195 Query: 416 PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAIL 475 PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAIL Sbjct: 196 PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAIL 255 Query: 476 KLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERA 535 KLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERA Sbjct: 256 KLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERA 315 Query: 536 CDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT 595 CDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT Sbjct: 316 CDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT 375 Query: 596 ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIA 655 ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIA Sbjct: 376 ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIA 435 Query: 656 STLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSE 715 STLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSE Sbjct: 436 STLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSE 495 Query: 716 GSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL-------------------- 755 GSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL Sbjct: 496 GSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSD 555 Query: 756 -TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDP----TVKCPTLKQ 810 +L+S + L H S S + I +LD+S N++ L +V L++ Sbjct: 556 DSLRS-SKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEK 614 Query: 811 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL--------------------- 849 L N L+ P+ L + ++ L L L NK + S L Sbjct: 615 LELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVV 674 Query: 850 -----RLKELKILNLSKNHISSLSEN---------------------------------- 870 + LK NLS N +S + EN Sbjct: 675 LDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILN 734 Query: 871 ------------FLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNL 918 FLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNL Sbjct: 735 LSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNL 794 Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN Sbjct: 795 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 854 Query: 979 KLKEI 983 KLKE+ Sbjct: 855 KLKEV 859 Score = 33.9 bits (76), Expect = 3.8 Identities = 52/251 (20%), Positives = 109/251 (43%), Gaps = 33/251 (13%) Query: 53 KLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVL 112 K+ K IH+ +L ++ ++ V + G +L L E G+ SL D+ + Sbjct: 33 KILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFE---GSNTSL----DI-----MA 80 Query: 113 GVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEE--------------SD 158 V IL ++ H S+ + + L+ + + G D E +D Sbjct: 81 AVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKND 140 Query: 159 IFMLIFDAMHSFPANDEVQKLGCKALHVLFERGNNVEVL-MSGNVRCYNIVVEAMKAFPM 217 I L+ A++ F N +QK G K + + + +E+L + G + V+ ++ +P Sbjct: 141 IHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEG---AMDSVLHTLQMYPD 197 Query: 218 SERIQEVSCCLL-HRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISAL-SCLALLR 275 + IQ + L+ + +T N F I + + + +V ++ ++ + A +Q + LA+L+ Sbjct: 198 DQEIQCLGLSLIGYLITKKNVF-IGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILK 256 Query: 276 SFPGICECIVN 286 + +V+ Sbjct: 257 LSASFSKLLVH 267 >gi|21740356|emb|CAD39185.1| hypothetical protein [Homo sapiens] Length = 400 Score = 631 bits (1627), Expect = e-180 Identities = 332/401 (82%), Positives = 336/401 (83%), Gaps = 56/401 (13%) Query: 1766 VFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTE 1825 VFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTE Sbjct: 1 VFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTE 60 Query: 1826 GYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTC 1885 GYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTC Sbjct: 61 GYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTC 120 Query: 1886 LYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSEST 1945 LYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSEST Sbjct: 121 LYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSEST 180 Query: 1946 NSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAK 2005 NSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAK Sbjct: 181 NSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAK 240 Query: 2006 QNSPVVEVWDKKTEKLCGLIDCVHFLSVIWMVLEGHTVKHK---TGSLKNV--------- 2053 QNSPVVEVWDKKTEKLCGLIDCVHFL + MV E KHK +G +K + Sbjct: 241 QNSPVVEVWDKKTEKLCGLIDCVHFLREV-MVKENKESKHKMSYSGRVKTLCLQKNTALW 299 Query: 2054 -------------------------------------------MLVLGYNRKNTEGTQKQ 2070 MLVLGYNRKNTEGTQKQ Sbjct: 300 IGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQ 359 Query: 2071 KEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2111 KEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE Sbjct: 360 KEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 400 >gi|14017797|dbj|BAB47419.1| KIAA1790 protein [Homo sapiens] Length = 1369 Score = 161 bits (408), Expect = 1e-38 Identities = 149/600 (24%), Positives = 268/600 (44%), Gaps = 106/600 (17%) Query: 1069 GKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLV----LNVWDFAGREEF 1124 GK+TLL+ L + + AT I W +Q R R V NVWD G Sbjct: 4 GKSTLLEILQTGRAPQVVHGEAT--IRTTKWELQ-RPAGSRAKVESVEFNVWDIGGPASM 60 Query: 1125 YSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQ 1184 + + F T +ALY+ V++L+ G+ V ++ WL NI+A+A ++ V++VGTHLD+ + K Sbjct: 61 ATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKF 120 Query: 1185 RKACMSKITKELL---------NKRGFPAIRDYHFVNATEES-DALAKLRKTIINESLNF 1234 R ++ + +L GFP I H + +S + LR+ I + + + Sbjct: 121 RVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSM 180 Query: 1235 K-----IRDQLVVGQLIPDCYVELEKIILSE--RKNVPIEFPVIDRKRLLQLVRE---NQ 1284 K I Q + G+LIP Y+ L++ +L+E R++ + + ++L QLV + N Sbjct: 181 KDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDND 240 Query: 1285 LQLDENELPHAVHFLNES-------------------------------VKVEGCPKHPK 1313 ++ D +L A+ FL E+ ++G K Sbjct: 241 IK-DYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAK 299 Query: 1314 GIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELP 1373 + R + + L F + QYF+ L KF+IALP+ + L+P L +P ++ Sbjct: 300 NGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTH 358 Query: 1374 HCEN--SEIIIRLYEMPYFPMGFWSRLINRLL----------------------EISPYM 1409 + + I R+++M + P+GFW R I R+L +++ Y Sbjct: 359 GMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYS 418 Query: 1410 LSGRE-------RALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPES-FLKITVPSCR 1461 +G + R R +YW++G+ + + + S+V +S +KI S Sbjct: 419 FTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEV 478 Query: 1462 KGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDG 1509 + + + DH++SL+++WFP L + +G L+++ WA ++ Sbjct: 479 RDFSAMAFITDHVNSLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKS 536 Query: 1510 EEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQ 1569 E+ Q ++D + A E D + P P L +P+ ++ P+L + D P + L N +LE + Sbjct: 537 EDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSE 596 Score = 102 bits (255), Expect = 7e-21 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%) Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632 I P +ELA SL+ +L ++ L L +IA +A GL YLH II+ D Sbjct: 681 IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 740 Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692 LK N+L+++L I K++DYGI++ G EGTPG++APE+ R ++Y+++ Sbjct: 741 LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 799 Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748 D++S+G++LY++L +G R G +L+I KL ++ P + ++ L Sbjct: 800 DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 852 Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808 + +C P++RP + V + + K ++ W G Sbjct: 853 MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 909 Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865 ++ +NTE E R+ C + L V++ W + T+ + + Sbjct: 910 ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 960 Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913 + +T ++ D+ + C K+ ++L L G ADG +A+F Sbjct: 961 TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 1009 >gi|33469143|ref|NP_078928.2| leucine-rich repeat kinase 1 [Homo sapiens] Length = 1310 Score = 147 bits (371), Expect = 2e-34 Identities = 130/534 (24%), Positives = 242/534 (45%), Gaps = 99/534 (18%) Query: 1131 FMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMS 1190 F T +ALY+ V++L+ G+ V ++ WL NI+A+A ++ V++VGTHLD+ + K R ++ Sbjct: 8 FFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIA 67 Query: 1191 KITKELL---------NKRGFPAIRDYHFVNATEES-DALAKLRKTIINESLNFK----- 1235 + +L GFP I H + +S + LR+ I + + + K Sbjct: 68 TLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGST 127 Query: 1236 IRDQLVVGQLIPDCYVELEKIILSE--RKNVPIEFPVIDRKRLLQLVRE---NQLQLDEN 1290 I Q + G+LIP Y+ L++ +L+E R++ + + ++L QLV + N ++ D Sbjct: 128 IGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIK-DYE 186 Query: 1291 ELPHAVHFLNES-------------------------------VKVEGCPKHPKGIISRR 1319 +L A+ FL E+ ++G K + R Sbjct: 187 DLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRA 246 Query: 1320 DVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCEN-- 1377 + + L F + QYF+ L KF+IALP+ + L+P L +P ++ + Sbjct: 247 EDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTHGMRHPT 305 Query: 1378 SEIIIRLYEMPYFPMGFWSRLINRLL----------------------EISPYMLSGRE- 1414 + I R+++M + P+GFW R I R+L +++ Y +G + Sbjct: 306 ANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQR 365 Query: 1415 ------RALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPES-FLKITVPSCRKGCILL 1467 R R +YW++G+ + + + S+V +S +KI S + + Sbjct: 366 NRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAM 425 Query: 1468 GQVVDHIDSLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDGEEHQKI 1515 + DH++SL+++WFP L + +G L+++ WA ++ E+ Q Sbjct: 426 AFITDHVNSLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYF 483 Query: 1516 LLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQ 1569 ++D + A E D + P P L +P+ ++ P+L + D P + L N +LE + Sbjct: 484 DMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSE 537 Score = 102 bits (255), Expect = 7e-21 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%) Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632 I P +ELA SL+ +L ++ L L +IA +A GL YLH II+ D Sbjct: 622 IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 681 Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692 LK N+L+++L I K++DYGI++ G EGTPG++APE+ R ++Y+++ Sbjct: 682 LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 740 Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748 D++S+G++LY++L +G R G +L+I KL ++ P + ++ L Sbjct: 741 DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 793 Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808 + +C P++RP + V + + K ++ W G Sbjct: 794 MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 850 Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865 ++ +NTE E R+ C + L V++ W + T+ + + Sbjct: 851 ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 901 Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913 + +T ++ D+ + C K+ ++L L G ADG +A+F Sbjct: 902 TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 950 >gi|4758704|ref|NP_004216.1| malignant fibrous histiocytoma amplified sequence 1 [Homo sapiens] gi|4239895|dbj|BAA74737.1| MASL1 [Homo sapiens] Length = 1052 Score = 108 bits (271), Expect = 9e-23 Identities = 128/501 (25%), Positives = 227/501 (45%), Gaps = 67/501 (13%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT-LKQFNLSY 815 L+ L L+L N+ + P+ L ++ + LDVS N + L ++ C + L+ ++ + Sbjct: 134 LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH---LPDSLSCLSRLRTLDVDH 190 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLSENFLEA 874 NQL+ P L +V LE+L + N++ G+ + L+ LKIL LS + +L F E Sbjct: 191 NQLTAFPRQLLQLVA-LEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCEL 249 Query: 875 CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 +ES N L A+P +FSC L L+ L++SSN + Sbjct: 250 A-SLESLMLDNNGLQALPA-------------QFSC-------LQRLKMLNLSSNLFEEF 288 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994 P A L EL S NQ++ + R+ L L +N+++ +P I L L Sbjct: 289 PA-ALLPLAGLEELYLSRNQLTSVPSLISGL--GRLLTLWLDNNRIRYLPDSIVELTGLE 345 Query: 995 SLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054 L + N ++ P+ G+LS++ + + L + K I Q+ L + P Sbjct: 346 ELVLQGN-QIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQP 404 Query: 1055 --YNRMKLMIVGNTGSGKTTLLQQLM------------KTKKSDLGMQSATVGIDVKDWP 1100 R+KL+++G+ +GKT L L K K + GI+V W Sbjct: 405 AVQPRLKLLLMGHKAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWT 464 Query: 1101 IQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAE--VDAMKPWL 1158 R L V+D AG E + P F++ ALY+ V +L+ + + +L Sbjct: 465 ADA----SRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFL 520 Query: 1159 FNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESD 1218 + AR ++ V +VGTH D+ E++ + I +++ A+++ H +++ Sbjct: 521 HRVGARVPNAVVCIVGTHADLCGERELEEKCLDIHRQI-------ALQEKH------DAE 567 Query: 1219 ALAKLRKTIINESL--NFKIR 1237 L++L K +++E+L +F++R Sbjct: 568 GLSRLAK-VVDEALARDFELR 587 Score = 58.9 bits (141), Expect = 1e-07 Identities = 48/180 (26%), Positives = 78/180 (43%), Gaps = 45/180 (25%) Query: 848 PLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNK 907 P L +++ LNL N + + E A S+ +L L +N+ Sbjct: 59 PANLGDIEALNLGNNGLEEVPEGLGSALG--------------------SLRVLVLRRNR 98 Query: 908 FSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLW 967 F+ +P A+ L H +L EL SHN+++ L +E Sbjct: 99 FARLPPAVAELGH-----------------------HLTELDVSHNRLTALG-AEVVSAL 134 Query: 968 SRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027 + KL+LSHN+L +P ++G L +L LDVS+N L P+ + LS++ L +D L Sbjct: 135 RELRKLNLSHNQLPALPAQLGALAHLEELDVSFN-RLAHLPDSLSCLSRLRTLDVDHNQL 193 >gi|34526495|dbj|BAC85125.1| FLJ00262 protein [Homo sapiens] Length = 1112 Score = 102 bits (255), Expect = 7e-21 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%) Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632 I P +ELA SL+ +L ++ L L +IA +A GL YLH II+ D Sbjct: 424 IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 483 Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692 LK N+L+++L I K++DYGI++ G EGTPG++APE+ R ++Y+++ Sbjct: 484 LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 542 Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748 D++S+G++LY++L +G R G +L+I KL ++ P + ++ L Sbjct: 543 DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 595 Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808 + +C P++RP + V + + K ++ W G Sbjct: 596 MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 652 Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865 ++ +NTE E R+ C + L V++ W + T+ + + Sbjct: 653 ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 703 Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913 + +T ++ D+ + C K+ ++L L G ADG +A+F Sbjct: 704 TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 752 Score = 97.4 bits (241), Expect = 3e-19 Identities = 73/300 (24%), Positives = 137/300 (45%), Gaps = 48/300 (16%) Query: 1314 GIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELP 1373 G+I D+ + L F + QYF+ L KF+IALP+ + L+P L +P ++ Sbjct: 44 GVIRAEDL-RMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTH 101 Query: 1374 HCEN--SEIIIRLYEMPYFPMGFWSRLINRLL----------------------EISPYM 1409 + + I R+++M + P+GFW R I R+L +++ Y Sbjct: 102 GMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYS 161 Query: 1410 LSGRE-------RALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPES-FLKITVPSCR 1461 +G + R R +YW++G+ + + + S+V +S +KI S Sbjct: 162 FTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEV 221 Query: 1462 KGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDG 1509 + + + DH++SL+++WFP L + +G L+++ WA ++ Sbjct: 222 RDFSAMAFITDHVNSLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKS 279 Query: 1510 EEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQ 1569 E+ Q ++D + A E D + P P L +P+ ++ P+L + D P + L N +LE + Sbjct: 280 EDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSE 339 >gi|31416932|gb|AAH05408.2| LRRK1 protein [Homo sapiens] Length = 659 Score = 102 bits (255), Expect = 7e-21 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%) Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632 I P +ELA SL+ +L ++ L L +IA +A GL YLH II+ D Sbjct: 3 IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 62 Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692 LK N+L+++L I K++DYGI++ G EGTPG++APE+ R ++Y+++ Sbjct: 63 LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 121 Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748 D++S+G++LY++L +G R G +L+I KL ++ P + ++ L Sbjct: 122 DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 174 Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808 + +C P++RP + V + + K ++ W G Sbjct: 175 MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 231 Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865 ++ +NTE E R+ C + L V++ W + T+ + + Sbjct: 232 ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 282 Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913 + +T ++ D+ + C K+ ++L L G ADG +A+F Sbjct: 283 TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 331 >gi|55661683|emb|CAH72812.1| OTTHUMP00000058851 [Homo sapiens] gi|29792199|gb|AAH50445.1| Soc-2 suppressor of clear homolog [Homo sapiens] gi|41281398|ref|NP_031399.2| soc-2 suppressor of clear homolog [Homo sapiens] gi|3252979|gb|AAC39856.1| Ras-binding protein SUR-8 [Homo sapiens] gi|3293320|gb|AAC25698.1| leucine-rich repeat protein SHOC-2 [Homo sapiens] gi|14423936|sp|Q9UQ13|SHO2_HUMAN Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8) Length = 582 Score = 94.7 bits (234), Expect = 2e-18 Identities = 83/327 (25%), Positives = 141/327 (43%), Gaps = 36/327 (11%) Query: 760 LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLS 819 +T+LDL N+ P + +S ++ L + N + S + KC L++ NL N +S Sbjct: 263 ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENNNIS 320 Query: 820 FVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEACPK 877 +PE+L + KL L L N ++ + P + + LN+ N I+ + Sbjct: 321 TLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKV 380 Query: 878 VESFSARMNFLAAMPF--------------------LPP------SMTILKLSQNKFSCI 911 + + + N L ++P +P S+ +L LS N + Sbjct: 381 LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 440 Query: 912 PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971 P + NL LR LD+ N ++ LP + +L++L+ ++NQ++ L + + Sbjct: 441 PHGLGNLRKLRELDLEENKLESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHL--TNLT 497 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDF 1031 L L N L +P EIG LENL L ++ N L S P E+ SK+ + ++ L+ Sbjct: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLP 557 Query: 1032 KHIGCKAKDIIRFLQQRLKKAVPYNRM 1058 I F+ Q LK PY M Sbjct: 558 PQIVAGGPS---FIIQFLKMQGPYRAM 581 Score = 74.7 bits (182), Expect = 2e-12 Identities = 62/223 (27%), Positives = 114/223 (51%), Gaps = 10/223 (4%) Query: 810 QFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLS 868 + +LS + +P ++ ++ + L +L L NK+ + + + L L L LS+N ++SL Sbjct: 104 RLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 162 Query: 869 ENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLD 925 ++ L+ K+ R N L +P + S+T L L N+ + + + I NL L L Sbjct: 163 DS-LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 221 Query: 926 MSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPP 985 + N I+ LP + NL L +HNQ+ L ++ +++ L L HN+L ++P Sbjct: 222 IRENKIKQLPAEIG-ELCNLITLDVAHNQLE--HLPKEIGNCTQITNLDLQHNELLDLPD 278 Query: 986 EIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028 IG L +L+ L + YN L + P + K S + +L L+ +++ Sbjct: 279 TIGNLSSLSRLGLRYN-RLSAIPRSLAKCSALEELNLENNNIS 320 Score = 70.5 bits (171), Expect = 4e-11 Identities = 86/317 (27%), Positives = 133/317 (41%), Gaps = 57/317 (17%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN------------------------- 791 LK L LDL NK PS + ++ + L + N Sbjct: 168 LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227 Query: 792 -----DIGP---SVVLD-----------PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKL 832 +IG + LD C + +L +N+L +P+ + + + L Sbjct: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGN-LSSL 286 Query: 833 EQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAM 891 +L L N++S I L + L+ LNL N+IS+L E+ L + K+ S + N Sbjct: 287 SRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLY 346 Query: 892 PFLPPSM--TI--LKLSQNKFSCIPEAILNLPH-LRSLDMSSNDIQYLP-GPAHWKSLNL 945 P PS TI L + N+ + IP I + L L+M N + LP W S + Sbjct: 347 PVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS--M 404 Query: 946 RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELR 1005 EL + NQ++ + E +E L LS+N LK++P +G L L LD+ N +L Sbjct: 405 VELNLATNQLT--KIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN-KLE 461 Query: 1006 SFPNEMGKLSKIWDLPL 1022 S PNE+ L + L L Sbjct: 462 SLPNEIAYLKDLQKLVL 478 Score = 67.4 bits (163), Expect = 3e-10 Identities = 86/343 (25%), Positives = 150/343 (43%), Gaps = 82/343 (23%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANL-DVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 L LT L L+SNK S P+ ++ C+ NL ++ ++ + + D L+ +L + Sbjct: 122 LTQLTELYLYSNKLQSLPA---EVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRH 178 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSL------- 867 N+L +P ++ ++ L L L N+I+ + ++ L +L +L++ +N I L Sbjct: 179 NKLREIP-SVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGEL 237 Query: 868 --------SENFLEACPK------------------------------VESFSARMNFLA 889 + N LE PK + R N L+ Sbjct: 238 CNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLS 297 Query: 890 AMP---FLPPSMTILKLSQNKFSCIPEAIL-NLPHLRSLDMSSNDIQYLP--GPAHWK-- 941 A+P ++ L L N S +PE++L +L L SL ++ N Q P GP+ + Sbjct: 298 AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTI 357 Query: 942 -SLN-------------------LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981 SLN L +L NQ++ L L W+ + +L+L+ N+L Sbjct: 358 YSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT--WTSMVELNLATNQLT 415 Query: 982 EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 +IP ++ L +L L +S NL L+ P+ +G L K+ +L L+E Sbjct: 416 KIPEDVSGLVSLEVLILSNNL-LKKLPHGLGNLRKLRELDLEE 457 >gi|40788390|dbj|BAA74885.2| KIAA0862 protein [Homo sapiens] Length = 584 Score = 94.7 bits (234), Expect = 2e-18 Identities = 83/327 (25%), Positives = 141/327 (43%), Gaps = 36/327 (11%) Query: 760 LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLS 819 +T+LDL N+ P + +S ++ L + N + S + KC L++ NL N +S Sbjct: 265 ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENNNIS 322 Query: 820 FVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEACPK 877 +PE+L + KL L L N ++ + P + + LN+ N I+ + Sbjct: 323 TLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKV 382 Query: 878 VESFSARMNFLAAMPF--------------------LPP------SMTILKLSQNKFSCI 911 + + + N L ++P +P S+ +L LS N + Sbjct: 383 LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 442 Query: 912 PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971 P + NL LR LD+ N ++ LP + +L++L+ ++NQ++ L + + Sbjct: 443 PHGLGNLRKLRELDLEENKLESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHL--TNLT 499 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDF 1031 L L N L +P EIG LENL L ++ N L S P E+ SK+ + ++ L+ Sbjct: 500 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPLELALCSKLSIMSIENCPLSHLP 559 Query: 1032 KHIGCKAKDIIRFLQQRLKKAVPYNRM 1058 I F+ Q LK PY M Sbjct: 560 PQIVAGGPS---FIIQFLKMQGPYRAM 583 Score = 74.7 bits (182), Expect = 2e-12 Identities = 62/223 (27%), Positives = 114/223 (51%), Gaps = 10/223 (4%) Query: 810 QFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLS 868 + +LS + +P ++ ++ + L +L L NK+ + + + L L L LS+N ++SL Sbjct: 106 RLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 164 Query: 869 ENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLD 925 ++ L+ K+ R N L +P + S+T L L N+ + + + I NL L L Sbjct: 165 DS-LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 223 Query: 926 MSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPP 985 + N I+ LP + NL L +HNQ+ L ++ +++ L L HN+L ++P Sbjct: 224 IRENKIKQLPAEIG-ELCNLITLDVAHNQLE--HLPKEIGNCTQITNLDLQHNELLDLPD 280 Query: 986 EIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028 IG L +L+ L + YN L + P + K S + +L L+ +++ Sbjct: 281 TIGNLSSLSRLGLRYN-RLSAIPRSLAKCSALEELNLENNNIS 322 Score = 70.5 bits (171), Expect = 4e-11 Identities = 86/317 (27%), Positives = 133/317 (41%), Gaps = 57/317 (17%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN------------------------- 791 LK L LDL NK PS + ++ + L + N Sbjct: 170 LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 229 Query: 792 -----DIGP---SVVLD-----------PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKL 832 +IG + LD C + +L +N+L +P+ + + + L Sbjct: 230 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGN-LSSL 288 Query: 833 EQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAM 891 +L L N++S I L + L+ LNL N+IS+L E+ L + K+ S + N Sbjct: 289 SRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLY 348 Query: 892 PFLPPSM--TI--LKLSQNKFSCIPEAILNLPH-LRSLDMSSNDIQYLP-GPAHWKSLNL 945 P PS TI L + N+ + IP I + L L+M N + LP W S + Sbjct: 349 PVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS--M 406 Query: 946 RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELR 1005 EL + NQ++ + E +E L LS+N LK++P +G L L LD+ N +L Sbjct: 407 VELNLATNQLT--KIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN-KLE 463 Query: 1006 SFPNEMGKLSKIWDLPL 1022 S PNE+ L + L L Sbjct: 464 SLPNEIAYLKDLQKLVL 480 Score = 67.4 bits (163), Expect = 3e-10 Identities = 86/343 (25%), Positives = 150/343 (43%), Gaps = 82/343 (23%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANL-DVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 L LT L L+SNK S P+ ++ C+ NL ++ ++ + + D L+ +L + Sbjct: 124 LTQLTELYLYSNKLQSLPA---EVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRH 180 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSL------- 867 N+L +P ++ ++ L L L N+I+ + ++ L +L +L++ +N I L Sbjct: 181 NKLREIP-SVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGEL 239 Query: 868 --------SENFLEACPK------------------------------VESFSARMNFLA 889 + N LE PK + R N L+ Sbjct: 240 CNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLS 299 Query: 890 AMP---FLPPSMTILKLSQNKFSCIPEAIL-NLPHLRSLDMSSNDIQYLP--GPAHWK-- 941 A+P ++ L L N S +PE++L +L L SL ++ N Q P GP+ + Sbjct: 300 AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTI 359 Query: 942 -SLN-------------------LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981 SLN L +L NQ++ L L W+ + +L+L+ N+L Sbjct: 360 YSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT--WTSMVELNLATNQLT 417 Query: 982 EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 +IP ++ L +L L +S NL L+ P+ +G L K+ +L L+E Sbjct: 418 KIPEDVSGLVSLEVLILSNNL-LKKLPHGLGNLRKLRELDLEE 459 Score = 33.1 bits (74), Expect = 6.4 Identities = 32/120 (26%), Positives = 48/120 (40%), Gaps = 14/120 (11%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L+ L LDL NK S P+ + + + L ++ N + + + L L N Sbjct: 449 LRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQL--TTLPRGIGHLTNLTHLGLGEN 506 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACP 876 L+ +PE + +E LE+L L N L L L S LS +E CP Sbjct: 507 LLTHLPEEI-GTLENLEELYLNDN-----------PNLHSLPLELALCSKLSIMSIENCP 554 >gi|55661684|emb|CAH72813.1| soc-2 suppressor of clear homolog (C. elegans) [Homo sapiens] Length = 372 Score = 93.6 bits (231), Expect = 4e-18 Identities = 83/330 (25%), Positives = 141/330 (42%), Gaps = 36/330 (10%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L L+ L + NK P+ + +S ++ L + N + S + KC L++ NL N Sbjct: 50 LSKLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENN 107 Query: 817 QLSFVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEA 874 +S +PE+L + KL L L N ++ + P + + LN+ N I+ + Sbjct: 108 NISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSR 167 Query: 875 CPKVESFSARMNFLAAMPF--------------------LPP------SMTILKLSQNKF 908 + + + N L ++P +P S+ +L LS N Sbjct: 168 AKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 227 Query: 909 SCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968 +P + NL LR LD+ N ++ LP + +L++L+ ++NQ++ L + Sbjct: 228 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHL--T 284 Query: 969 RVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028 + L L N L +P EIG LENL L ++ N L S P E+ SK+ + ++ L+ Sbjct: 285 NLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 344 Query: 1029 FDFKHIGCKAKDIIRFLQQRLKKAVPYNRM 1058 I F+ Q LK PY M Sbjct: 345 HLPPQIVAGGPS---FIIQFLKMQGPYRAM 371 Score = 85.9 bits (211), Expect = 8e-16 Identities = 88/322 (27%), Positives = 136/322 (42%), Gaps = 60/322 (18%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP--------------------- 795 LK L LDL NK PS + ++ + L + N I Sbjct: 4 LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 63 Query: 796 -----------------------SVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKL 832 S + KC L++ NL N +S +PE+L + KL Sbjct: 64 KQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKL 123 Query: 833 EQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAA 890 L L N ++ + P + + LN+ N I+ + + + + N L + Sbjct: 124 NSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTS 183 Query: 891 MPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP-GPAHWKSLNLR 946 +P SM L L+ N+ + IPE + L L L +S+N ++ LP G + + LR Sbjct: 184 LPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLR--KLR 241 Query: 947 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006 EL N++ L +E AYL ++KL L++N+L +P IG L NLT L + NL L Sbjct: 242 ELDLEENKLESLP-NEIAYL-KDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENL-LTH 298 Query: 1007 FPNEMGKLSKIWDLPLDELHLN 1028 P E+G L L+EL+LN Sbjct: 299 LPEEIGTLEN-----LEELYLN 315 Score = 48.9 bits (115), Expect = 1e-04 Identities = 76/347 (21%), Positives = 147/347 (42%), Gaps = 59/347 (17%) Query: 643 DKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSM 702 +K L + S+L+R+ +RY SA+ A S E++ + + + +P+S + Sbjct: 61 NKIKQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKCS---ALEELNLENNNISTLPESLL 117 Query: 703 DSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTH 762 S+ K NS++ L R L ++ Sbjct: 118 SSLV-------------------KLNSLT---------LARNCFQLYPVGGPSQFSTIYS 149 Query: 763 LDLHSNKFTSFP-SYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFV 821 L++ N+ P + ++ L++ N + S+ LD ++ + NL+ NQL+ + Sbjct: 150 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL-TSLPLD-FGTWTSMVELNLATNQLTKI 207 Query: 822 PENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVES 880 PE+++ +V LE LIL N + + L L++L+ L+L +N K+ES Sbjct: 208 PEDVSGLV-SLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN--------------KLES 252 Query: 881 FSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHW 940 + +L + L L+ N+ + +P I +L +L L + N + +LP Sbjct: 253 LPNEIAYL-------KDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGT 305 Query: 941 KSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEI 987 NL EL + N ++ L + L S++ + + + L +PP+I Sbjct: 306 LE-NLEELYLNDNP-NLHSLPFELALCSKLSIMSIENCPLSHLPPQI 350 Score = 38.5 bits (88), Expect = 0.15 Identities = 41/161 (25%), Positives = 71/161 (44%), Gaps = 7/161 (4%) Query: 872 LEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSS 928 L+ K+ R N L +P + S+T L L N+ + + + I NL L L + Sbjct: 1 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 60 Query: 929 NDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPE-I 987 N I+ LP S +L L +N++S + S S +E+L+L +N + +P + Sbjct: 61 NKIKQLPAEIGNLS-SLSRLGLRYNRLSAIPRS--LAKCSALEELNLENNNISTLPESLL 117 Query: 988 GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028 L L SL ++ N + S I+ L ++ +N Sbjct: 118 SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN 158 >gi|32812252|gb|AAP88017.1| CRIB1 [Homo sapiens] gi|45827729|ref|NP_056171.2| scribble isoform b [Homo sapiens] gi|50400856|sp|Q14160|LAP4_HUMAN LAP4 protein (Scribble homolog protein) (hScrib) gi|20521832|dbj|BAA09768.3| KIAA0147 protein [Homo sapiens] Length = 1630 Score = 88.2 bits (217), Expect = 2e-16 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815 L +L L L N+ P + + LDVSRNDI + ++K C L+ + S Sbjct: 58 LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 114 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N LS +P+ T + L L L + + + L L L L +N + SL + L Sbjct: 115 NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172 Query: 875 CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 K+E N L +P P++ L L +N+ S +P + NL L LD+S N + Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 + LP L L +LL S N + L + ++ L + N+L E+ IG E Sbjct: 233 EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289 Query: 992 NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050 NL+ L ++ NL L + P +GKL+K+ +L +D HL I GC A ++ RL Sbjct: 290 NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348 Query: 1051 KAVP 1054 P Sbjct: 349 VLPP 352 Score = 74.7 bits (182), Expect = 2e-12 Identities = 77/268 (28%), Positives = 128/268 (47%), Gaps = 8/268 (2%) Query: 801 PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNL 859 P + L++ LS N++ +P + + ++ +E L + N I I ++ K L+I + Sbjct: 54 PFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADF 112 Query: 860 SKNHISSLSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 S N +S L + F L + + + L ++ L+L +N +P ++ Sbjct: 113 SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172 Query: 918 LPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSH 977 L L LD+ ND++ LP NLREL NQ+S L E L R+ L +S Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSE 229 Query: 978 NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK 1037 N+L+E+P E+G L LT L +S NL LR P+ +G+L ++ L +D+ L + IG Sbjct: 230 NRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDC 288 Query: 1038 AKDIIRFLQQRLKKAVPYNRMKLMIVGN 1065 L + L A+P + KL + N Sbjct: 289 ENLSELILTENLLMALPRSLGKLTKLTN 316 Score = 69.7 bits (169), Expect = 6e-11 Identities = 70/234 (29%), Positives = 100/234 (42%), Gaps = 32/234 (13%) Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 L VPE + LE+L+L+ N++ + P RL L+ L LS N I L Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83 Query: 877 KVESFSARMNFLAAMPFLPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSND 930 VE +R + +P +P S+ K S N S +P+ L L L ++ Sbjct: 84 LVELDVSRND----IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139 Query: 931 IQYLPGP----AHWKSLNLRELLFSHNQISI--------LDLS--------EKAYLWSRV 970 +Q LPG A+ +L LRE L S+ LDL + + Sbjct: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199 Query: 971 EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 +L L N+L +PPE+G L L LDVS N L P E+G L + DL L + Sbjct: 200 RELWLDRNQLSALPPELGNLRRLVCLDVSEN-RLEELPAELGGLVLLTDLLLSQ 252 Score = 57.0 bits (136), Expect = 4e-07 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815 L+SL HL L+ + P + ++ + L++ N + L VK L+Q +L Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 183 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N L +P+ L + L +L L+ N++S + L L+ L L++S+N + L L Sbjct: 184 NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 241 Query: 875 CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 + N L +P ++ILK+ QN+ + EAI + +L L ++ N + Sbjct: 242 LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 LP K L L N + L + V L L N+L +PPE+ Sbjct: 302 MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 358 Query: 992 NLTSLDVSYNLELRSFP 1008 L LDV+ N L+S P Sbjct: 359 ELHVLDVAGN-RLQSLP 374 Score = 47.8 bits (112), Expect = 3e-04 Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 25/167 (14%) Query: 910 CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969 CIP N H+ S+D +Q +P + S +L ELL NQ+ +L + + Sbjct: 4 CIPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLR--ELPKPFFRLLN 60 Query: 970 VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN--------------LELRSF-------- 1007 + KL LS N+++ +PPE+ L LDVS N LE+ F Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120 Query: 1008 PNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054 P+ +L + L L+++ L +G A + L++ L K++P Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167 >gi|32812254|gb|AAP88018.1| SCRIB1 variant N1 [Homo sapiens] Length = 1601 Score = 88.2 bits (217), Expect = 2e-16 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815 L +L L L N+ P + + LDVSRNDI + ++K C L+ + S Sbjct: 29 LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 85 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N LS +P+ T + L L L + + + L L L L +N + SL + L Sbjct: 86 NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 143 Query: 875 CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 K+E N L +P P++ L L +N+ S +P + NL L LD+S N + Sbjct: 144 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 203 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 + LP L L +LL S N + L + ++ L + N+L E+ IG E Sbjct: 204 EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 260 Query: 992 NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050 NL+ L ++ NL L + P +GKL+K+ +L +D HL I GC A ++ RL Sbjct: 261 NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 319 Query: 1051 KAVP 1054 P Sbjct: 320 VLPP 323 Score = 73.9 bits (180), Expect = 3e-12 Identities = 76/261 (29%), Positives = 126/261 (48%), Gaps = 8/261 (3%) Query: 808 LKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHISS 866 L++ LS N++ +P + + ++ +E L + N I I ++ K L+I + S N +S Sbjct: 32 LRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 90 Query: 867 LSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSL 924 L + F L + + + L ++ L+L +N +P ++ L L L Sbjct: 91 LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 150 Query: 925 DMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIP 984 D+ ND++ LP NLREL NQ+S L E L R+ L +S N+L+E+P Sbjct: 151 DLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSENRLEELP 207 Query: 985 PEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRF 1044 E+G L LT L +S NL LR P+ +G+L ++ L +D+ L + IG Sbjct: 208 AELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 266 Query: 1045 LQQRLKKAVPYNRMKLMIVGN 1065 L + L A+P + KL + N Sbjct: 267 LTENLLMALPRSLGKLTKLTN 287 Score = 57.0 bits (136), Expect = 4e-07 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815 L+SL HL L+ + P + ++ + L++ N + L VK L+Q +L Sbjct: 98 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 154 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N L +P+ L + L +L L+ N++S + L L+ L L++S+N + L L Sbjct: 155 NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 212 Query: 875 CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 + N L +P ++ILK+ QN+ + EAI + +L L ++ N + Sbjct: 213 LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 272 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 LP K L L N + L + V L L N+L +PPE+ Sbjct: 273 MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 329 Query: 992 NLTSLDVSYNLELRSFP 1008 L LDV+ N L+S P Sbjct: 330 ELHVLDVAGN-RLQSLP 345 >gi|45827731|ref|NP_874365.2| scribble isoform a [Homo sapiens] Length = 1655 Score = 88.2 bits (217), Expect = 2e-16 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815 L +L L L N+ P + + LDVSRNDI + ++K C L+ + S Sbjct: 58 LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 114 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N LS +P+ T + L L L + + + L L L L +N + SL + L Sbjct: 115 NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172 Query: 875 CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 K+E N L +P P++ L L +N+ S +P + NL L LD+S N + Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 + LP L L +LL S N + L + ++ L + N+L E+ IG E Sbjct: 233 EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289 Query: 992 NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050 NL+ L ++ NL L + P +GKL+K+ +L +D HL I GC A ++ RL Sbjct: 290 NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348 Query: 1051 KAVP 1054 P Sbjct: 349 VLPP 352 Score = 74.7 bits (182), Expect = 2e-12 Identities = 77/268 (28%), Positives = 128/268 (47%), Gaps = 8/268 (2%) Query: 801 PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNL 859 P + L++ LS N++ +P + + ++ +E L + N I I ++ K L+I + Sbjct: 54 PFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADF 112 Query: 860 SKNHISSLSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 S N +S L + F L + + + L ++ L+L +N +P ++ Sbjct: 113 SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172 Query: 918 LPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSH 977 L L LD+ ND++ LP NLREL NQ+S L E L R+ L +S Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSE 229 Query: 978 NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK 1037 N+L+E+P E+G L LT L +S NL LR P+ +G+L ++ L +D+ L + IG Sbjct: 230 NRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDC 288 Query: 1038 AKDIIRFLQQRLKKAVPYNRMKLMIVGN 1065 L + L A+P + KL + N Sbjct: 289 ENLSELILTENLLMALPRSLGKLTKLTN 316 Score = 69.7 bits (169), Expect = 6e-11 Identities = 70/234 (29%), Positives = 100/234 (42%), Gaps = 32/234 (13%) Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 L VPE + LE+L+L+ N++ + P RL L+ L LS N I L Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83 Query: 877 KVESFSARMNFLAAMPFLPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSND 930 VE +R + +P +P S+ K S N S +P+ L L L ++ Sbjct: 84 LVELDVSRND----IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139 Query: 931 IQYLPGP----AHWKSLNLRELLFSHNQISI--------LDLS--------EKAYLWSRV 970 +Q LPG A+ +L LRE L S+ LDL + + Sbjct: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199 Query: 971 EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 +L L N+L +PPE+G L L LDVS N L P E+G L + DL L + Sbjct: 200 RELWLDRNQLSALPPELGNLRRLVCLDVSEN-RLEELPAELGGLVLLTDLLLSQ 252 Score = 57.0 bits (136), Expect = 4e-07 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815 L+SL HL L+ + P + ++ + L++ N + L VK L+Q +L Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 183 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N L +P+ L + L +L L+ N++S + L L+ L L++S+N + L L Sbjct: 184 NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 241 Query: 875 CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 + N L +P ++ILK+ QN+ + EAI + +L L ++ N + Sbjct: 242 LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 LP K L L N + L + V L L N+L +PPE+ Sbjct: 302 MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 358 Query: 992 NLTSLDVSYNLELRSFP 1008 L LDV+ N L+S P Sbjct: 359 ELHVLDVAGN-RLQSLP 374 Score = 47.8 bits (112), Expect = 3e-04 Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 25/167 (14%) Query: 910 CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969 CIP N H+ S+D +Q +P + S +L ELL NQ+ +L + + Sbjct: 4 CIPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLR--ELPKPFFRLLN 60 Query: 970 VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN--------------LELRSF-------- 1007 + KL LS N+++ +PPE+ L LDVS N LE+ F Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120 Query: 1008 PNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054 P+ +L + L L+++ L +G A + L++ L K++P Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167 >gi|18032008|gb|AAL38976.1| scribble [Homo sapiens] Length = 1630 Score = 88.2 bits (217), Expect = 2e-16 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815 L +L L L N+ P + + LDVSRNDI + ++K C L+ + S Sbjct: 58 LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 114 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N LS +P+ T + L L L + + + L L L L +N + SL + L Sbjct: 115 NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172 Query: 875 CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 K+E N L +P P++ L L +N+ S +P + NL L LD+S N + Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 + LP L L +LL S N + L + ++ L + N+L E+ IG E Sbjct: 233 EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289 Query: 992 NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050 NL+ L ++ NL L + P +GKL+K+ +L +D HL I GC A ++ RL Sbjct: 290 NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348 Query: 1051 KAVP 1054 P Sbjct: 349 VLPP 352 Score = 74.7 bits (182), Expect = 2e-12 Identities = 77/268 (28%), Positives = 128/268 (47%), Gaps = 8/268 (2%) Query: 801 PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNL 859 P + L++ LS N++ +P + + ++ +E L + N I I ++ K L+I + Sbjct: 54 PFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADF 112 Query: 860 SKNHISSLSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 S N +S L + F L + + + L ++ L+L +N +P ++ Sbjct: 113 SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172 Query: 918 LPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSH 977 L L LD+ ND++ LP NLREL NQ+S L E L R+ L +S Sbjct: 173 LVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSE 229 Query: 978 NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK 1037 N+L+E+P E+G L LT L +S NL LR P+ +G+L ++ L +D+ L + IG Sbjct: 230 NRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDC 288 Query: 1038 AKDIIRFLQQRLKKAVPYNRMKLMIVGN 1065 L + L A+P + KL + N Sbjct: 289 ENLSELILTENLLMALPRSLGKLTKLTN 316 Score = 69.7 bits (169), Expect = 6e-11 Identities = 70/234 (29%), Positives = 100/234 (42%), Gaps = 32/234 (13%) Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 L VPE + LE+L+L+ N++ + P RL L+ L LS N I L Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83 Query: 877 KVESFSARMNFLAAMPFLPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSND 930 VE +R + +P +P S+ K S N S +P+ L L L ++ Sbjct: 84 LVELDVSRND----IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139 Query: 931 IQYLPGP----AHWKSLNLRELLFSHNQISI--------LDLS--------EKAYLWSRV 970 +Q LPG A+ +L LRE L S+ LDL + + Sbjct: 140 LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199 Query: 971 EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 +L L N+L +PPE+G L L LDVS N L P E+G L + DL L + Sbjct: 200 RELWLDRNQLSALPPELGNLRRLVCLDVSEN-RLEELPAELGGLVLLTDLLLSQ 252 Score = 57.0 bits (136), Expect = 4e-07 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815 L+SL HL L+ + P + ++ + L++ N + L VK L+Q +L Sbjct: 127 LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 183 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N L +P+ L + L +L L+ N++S + L L+ L L++S+N + L L Sbjct: 184 NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 241 Query: 875 CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931 + N L +P ++ILK+ QN+ + EAI + +L L ++ N + Sbjct: 242 LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301 Query: 932 QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 LP K L L N + L + V L L N+L +PPE+ Sbjct: 302 MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 358 Query: 992 NLTSLDVSYNLELRSFP 1008 L LDV+ N L+S P Sbjct: 359 ELHVLDVAGN-RLQSLP 374 Score = 47.8 bits (112), Expect = 3e-04 Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 25/167 (14%) Query: 910 CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969 CIP N H+ S+D +Q +P + S +L ELL NQ+ +L + + Sbjct: 4 CIPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLR--ELPKPFFRLLN 60 Query: 970 VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN--------------LELRSF-------- 1007 + KL LS N+++ +PPE+ L LDVS N LE+ F Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120 Query: 1008 PNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054 P+ +L + L L+++ L +G A + L++ L K++P Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167 >gi|56205237|emb|CAI22332.1| novel protein [Homo sapiens] gi|10434638|dbj|BAB14326.1| unnamed protein product [Homo sapiens] gi|21361633|ref|NP_060238.3| hypothetical protein FLJ20331 [Homo sapiens] gi|14250313|gb|AAH08586.1| Hypothetical protein FLJ20331 [Homo sapiens] Length = 602 Score = 85.9 bits (211), Expect = 8e-16 Identities = 84/304 (27%), Positives = 147/304 (48%), Gaps = 39/304 (12%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L +LT LD+H N+ TS PS + ++ L++ N+S+N Sbjct: 104 LPALTVLDIHDNQLTSLPSAIRELE-------------------------NLQKLNVSHN 138 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875 +L +PE +T++ L+ L L+ N+++ I +L L+ L+LS NH++++ +F Sbjct: 139 KLKILPEEITNL-RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLS 197 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQ 932 V + N L ++P M LK + N IP + + L L + N ++ Sbjct: 198 SLVR-LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 256 Query: 933 YLPGPAHWKSLNL-RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 +LP + S +L +EL NQI +L+ +L S + L L NKLK +P EI L Sbjct: 257 FLP---EFPSCSLLKELHVGENQIEMLEAEHLKHLNS-ILVLDLRDNKLKSVPDEIILLR 312 Query: 992 NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK-AKDIIRFLQQRLK 1050 +L LD+S N ++ S P +G L + L L+ L + I K ++++++L+ ++K Sbjct: 313 SLERLDLSNN-DISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIK 370 Query: 1051 KAVP 1054 P Sbjct: 371 DDGP 374 Score = 67.0 bits (162), Expect = 4e-10 Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 7/200 (3%) Query: 821 VPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHIS-SLSENFLEACP--K 877 VP+ L K QL L G +S + + + I + ++S +E + E K Sbjct: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTK 86 Query: 878 VESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGP 937 + + ++ L L P++T+L + N+ + +P AI L +L+ L++S N ++ LP Sbjct: 87 LIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEE 146 Query: 938 AHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLD 997 NL+ L HN+++ +SE S +E L LS+N L +P L +L L+ Sbjct: 147 I-TNLRNLKCLYLQHNELTC--ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203 Query: 998 VSYNLELRSFPNEMGKLSKI 1017 +S N EL+S P E+ ++ ++ Sbjct: 204 LSSN-ELKSLPAEINRMKRL 222 Score = 63.9 bits (154), Expect = 3e-09 Identities = 73/263 (27%), Positives = 117/263 (44%), Gaps = 34/263 (12%) Query: 771 TSFPSYLLKMSCIAN-LDVSRNDIG--PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTD 827 TS P LLK + + L++S ++ P V V P NLS+ E TD Sbjct: 25 TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQ-TD 83 Query: 828 VVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMN 886 L +LI+ NK+ + LRL L +L++ N ++SL E Sbjct: 84 ----LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIREL------------ 127 Query: 887 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946 ++ L +S NK +PE I NL +L+ L + N++ + S NL Sbjct: 128 ---------ENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLE 177 Query: 947 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006 +L S+N ++ + S + S + +L+LS N+LK +P EI ++ L LD + NL L + Sbjct: 178 DLDLSNNHLTTVPASFSSL--SSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNL-LET 234 Query: 1007 FPNEMGKLSKIWDLPLDELHLNF 1029 P E+ + + L L L F Sbjct: 235 IPPELAGMESLELLYLRRNKLRF 257 Score = 61.2 bits (147), Expect = 2e-08 Identities = 49/193 (25%), Positives = 88/193 (45%), Gaps = 25/193 (12%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISS 866 TLK + S Q + +P+ + D V+ N ++ I N SKN + Sbjct: 400 TLKILDYSDKQATLIPDEVFDAVKS--------NIVTSI------------NFSKNQLCE 439 Query: 867 LSENFLEACPKVESFSARMN---FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS 923 + + +E V N F++ + +T L L N + +PE + +L L++ Sbjct: 440 IPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQT 499 Query: 924 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI 983 +++S N + LP ++ L +L S+NQ+ +D +K + + L L +N L +I Sbjct: 500 INLSFNRFKMLP-EVLYRIFTLETILISNNQVGSVD-PQKMKMMENLTTLDLQNNDLLQI 557 Query: 984 PPEIGCLENLTSL 996 PPE+G NL +L Sbjct: 558 PPELGNCVNLRTL 570 Score = 58.5 bits (140), Expect = 1e-07 Identities = 73/290 (25%), Positives = 126/290 (43%), Gaps = 27/290 (9%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG--PSVVLDPTVKCPTLKQFNLS 814 L S+ LDL NK S P ++ + + LD+S NDI P + + +K L+ L Sbjct: 288 LNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLR 347 Query: 815 YNQLSFVPENLTDVVEKLEQLILEGNKISG---------ICSPLRLK-----ELKILNLS 860 + + + +V++ L I + + S R+ LKIL+ S Sbjct: 348 TIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYS 407 Query: 861 KNHISSLSENFLEACPK--VESFSARMNFLAAMPF----LPPSMTILKLSQNKFSCIPEA 914 + + + +A V S + N L +P L ++ + LS NK S I Sbjct: 408 DKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE 467 Query: 915 ILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLH 974 + L L LD+ +N + LP + L+ + S N+ +L E Y +E + Sbjct: 468 LCVLQKLTFLDLRNNFLNSLPEEME-SLVRLQTINLSFNRFKMLP--EVLYRIFTLETIL 524 Query: 975 LSHNKLKEIPPE-IGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLD 1023 +S+N++ + P+ + +ENLT+LD+ N +L P E+G + L LD Sbjct: 525 ISNNQVGSVDPQKMKMMENLTTLDLQNN-DLLQIPPELGNCVNLRTLLLD 573 Score = 57.4 bits (137), Expect = 3e-07 Identities = 73/289 (25%), Positives = 114/289 (39%), Gaps = 28/289 (9%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 +K L HLD +SN + P L M + L + RN + L C LK+ ++ N Sbjct: 219 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR---FLPEFPSCSLLKELHVGEN 275 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875 Q+ + + + L L NK+ + + L+ L+ L+LS N ISSL + Sbjct: 276 QIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH 335 Query: 876 PKVESFSAR-MNFLAAMPFLPPSMTILKLSQNKFS--------CIPEAILNLPH------ 920 K + + + + +LK ++K E + LP Sbjct: 336 LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNI 395 Query: 921 -----LRSLDMSSNDIQYLPGPAH--WKSLNLRELLFSHNQISILDLSEKAYLWSRVEKL 973 L+ LD S +P KS + + FS NQ+ + L V + Sbjct: 396 HAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIP-KRMVELKEMVSDV 454 Query: 974 HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 LS NKL I E+ L+ LT LD+ N L S P EM L ++ + L Sbjct: 455 DLSFNKLSFISLELCVLQKLTFLDLRNNF-LNSLPEEMESLVRLQTINL 502 Score = 57.0 bits (136), Expect = 4e-07 Identities = 45/168 (26%), Positives = 85/168 (50%), Gaps = 8/168 (4%) Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKE 853 P V D VK + N S NQL +P+ + ++ E + + L NK+S I L L++ Sbjct: 415 PDEVFD-AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQK 473 Query: 854 LKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSC 910 L L+L N ++SL E +E+ ++++ + N +P + ++ + +S N+ Sbjct: 474 LTFLDLRNNFLNSLPEE-MESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532 Query: 911 I-PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISI 957 + P+ + + +L +LD+ +ND+ +P P +NLR LL N + Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIP-PELGNCVNLRTLLLDGNPFRV 579 Score = 51.2 bits (121), Expect = 2e-05 Identities = 53/193 (27%), Positives = 78/193 (40%), Gaps = 49/193 (25%) Query: 756 TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 +L SL L+L SN+ S P+ + +M + +LD + Sbjct: 195 SLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNS------------------------- 229 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875 N L +P L +E LE L L NK+ + LK L++ +N I L L+ Sbjct: 230 NLLETIPPELAG-MESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLK-- 286 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935 +N S+ +L L NK +P+ I+ L L LD+S+NDI LP Sbjct: 287 --------HLN----------SILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 328 Query: 936 ---GPAHWKSLNL 945 G H K L L Sbjct: 329 YSLGNLHLKFLAL 341 Score = 35.4 bits (80), Expect = 1.3 Identities = 61/252 (24%), Positives = 103/252 (40%), Gaps = 23/252 (9%) Query: 608 LLLRRLA-LDVANNSICLGGFCIGKVEPSWLG----PLFPDKTSNLRKQTNIASTLARMV 662 +LLR L LD++NN I + +G + +L PL + + K T R Sbjct: 309 ILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 368 Query: 663 IR----YQMKSAVEEGTASGSDG--NFSEDVLSKFDEW-----TFIPDSSMDSVFAQSDD 711 I+ Q +SA E S+ N + K ++ T IPD D+V +S+ Sbjct: 369 IKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAV--KSNI 426 Query: 712 LDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL-TLKSLTHLDLHSNKF 770 + S + L + + + E D L L S L L+ LT LDL +N Sbjct: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLS--FNKLSFISLELCVLQKLTFLDLRNNFL 484 Query: 771 TSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVE 830 S P + + + +++S N ++ + + TL+ +S NQ+ V ++E Sbjct: 485 NSLPEEMESLVRLQTINLSFNRF--KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMME 542 Query: 831 KLEQLILEGNKI 842 L L L+ N + Sbjct: 543 NLTTLDLQNNDL 554 >gi|32425389|gb|AAH03407.2| FLJ20331 protein [Homo sapiens] Length = 581 Score = 85.9 bits (211), Expect = 8e-16 Identities = 84/304 (27%), Positives = 147/304 (48%), Gaps = 39/304 (12%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L +LT LD+H N+ TS PS + ++ L++ N+S+N Sbjct: 83 LPALTVLDIHDNQLTSLPSAIRELE-------------------------NLQKLNVSHN 117 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875 +L +PE +T++ L+ L L+ N+++ I +L L+ L+LS NH++++ +F Sbjct: 118 KLKILPEEITNL-RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLS 176 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQ 932 V + N L ++P M LK + N IP + + L L + N ++ Sbjct: 177 SLVR-LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 235 Query: 933 YLPGPAHWKSLNL-RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991 +LP + S +L +EL NQI +L+ +L S + L L NKLK +P EI L Sbjct: 236 FLP---EFPSCSLLKELHVGENQIEMLEAEHLKHLNS-ILVLDLRDNKLKSVPDEIILLR 291 Query: 992 NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK-AKDIIRFLQQRLK 1050 +L LD+S N ++ S P +G L + L L+ L + I K ++++++L+ ++K Sbjct: 292 SLERLDLSNN-DISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIK 349 Query: 1051 KAVP 1054 P Sbjct: 350 DDGP 353 Score = 67.0 bits (162), Expect = 4e-10 Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 7/200 (3%) Query: 821 VPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHIS-SLSENFLEACP--K 877 VP+ L K QL L G +S + + + I + ++S +E + E K Sbjct: 6 VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTK 65 Query: 878 VESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGP 937 + + ++ L L P++T+L + N+ + +P AI L +L+ L++S N ++ LP Sbjct: 66 LIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEE 125 Query: 938 AHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLD 997 NL+ L HN+++ +SE S +E L LS+N L +P L +L L+ Sbjct: 126 I-TNLRNLKCLYLQHNELTC--ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 182 Query: 998 VSYNLELRSFPNEMGKLSKI 1017 +S N EL+S P E+ ++ ++ Sbjct: 183 LSSN-ELKSLPAEINRMKRL 201 Score = 63.9 bits (154), Expect = 3e-09 Identities = 73/263 (27%), Positives = 117/263 (44%), Gaps = 34/263 (12%) Query: 771 TSFPSYLLKMSCIAN-LDVSRNDIG--PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTD 827 TS P LLK + + L++S ++ P V V P NLS+ E TD Sbjct: 4 TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQ-TD 62 Query: 828 VVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMN 886 L +LI+ NK+ + LRL L +L++ N ++SL E Sbjct: 63 ----LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIREL------------ 106 Query: 887 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946 ++ L +S NK +PE I NL +L+ L + N++ + S NL Sbjct: 107 ---------ENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLE 156 Query: 947 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006 +L S+N ++ + S + S + +L+LS N+LK +P EI ++ L LD + NL L + Sbjct: 157 DLDLSNNHLTTVPASFSSL--SSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNL-LET 213 Query: 1007 FPNEMGKLSKIWDLPLDELHLNF 1029 P E+ + + L L L F Sbjct: 214 IPPELAGMESLELLYLRRNKLRF 236 Score = 61.2 bits (147), Expect = 2e-08 Identities = 49/193 (25%), Positives = 88/193 (45%), Gaps = 25/193 (12%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISS 866 TLK + S Q + +P+ + D V+ N ++ I N SKN + Sbjct: 379 TLKILDYSDKQATLIPDEVFDAVKS--------NIVTSI------------NFSKNQLCE 418 Query: 867 LSENFLEACPKVESFSARMN---FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS 923 + + +E V N F++ + +T L L N + +PE + +L L++ Sbjct: 419 IPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQT 478 Query: 924 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI 983 +++S N + LP ++ L +L S+NQ+ +D +K + + L L +N L +I Sbjct: 479 INLSFNRFKMLP-EVLYRIFTLETILISNNQVGSVD-PQKMKMMENLTTLDLQNNDLLQI 536 Query: 984 PPEIGCLENLTSL 996 PPE+G NL +L Sbjct: 537 PPELGNCVNLRTL 549 Score = 58.5 bits (140), Expect = 1e-07 Identities = 73/290 (25%), Positives = 126/290 (43%), Gaps = 27/290 (9%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG--PSVVLDPTVKCPTLKQFNLS 814 L S+ LDL NK S P ++ + + LD+S NDI P + + +K L+ L Sbjct: 267 LNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLR 326 Query: 815 YNQLSFVPENLTDVVEKLEQLILEGNKISG---------ICSPLRLK-----ELKILNLS 860 + + + +V++ L I + + S R+ LKIL+ S Sbjct: 327 TIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYS 386 Query: 861 KNHISSLSENFLEACPK--VESFSARMNFLAAMPF----LPPSMTILKLSQNKFSCIPEA 914 + + + +A V S + N L +P L ++ + LS NK S I Sbjct: 387 DKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE 446 Query: 915 ILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLH 974 + L L LD+ +N + LP + L+ + S N+ +L E Y +E + Sbjct: 447 LCVLQKLTFLDLRNNFLNSLPEEME-SLVRLQTINLSFNRFKMLP--EVLYRIFTLETIL 503 Query: 975 LSHNKLKEIPPE-IGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLD 1023 +S+N++ + P+ + +ENLT+LD+ N +L P E+G + L LD Sbjct: 504 ISNNQVGSVDPQKMKMMENLTTLDLQNN-DLLQIPPELGNCVNLRTLLLD 552 Score = 57.4 bits (137), Expect = 3e-07 Identities = 73/289 (25%), Positives = 114/289 (39%), Gaps = 28/289 (9%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 +K L HLD +SN + P L M + L + RN + L C LK+ ++ N Sbjct: 198 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR---FLPEFPSCSLLKELHVGEN 254 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875 Q+ + + + L L NK+ + + L+ L+ L+LS N ISSL + Sbjct: 255 QIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH 314 Query: 876 PKVESFSAR-MNFLAAMPFLPPSMTILKLSQNKFS--------CIPEAILNLPH------ 920 K + + + + +LK ++K E + LP Sbjct: 315 LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNI 374 Query: 921 -----LRSLDMSSNDIQYLPGPAH--WKSLNLRELLFSHNQISILDLSEKAYLWSRVEKL 973 L+ LD S +P KS + + FS NQ+ + L V + Sbjct: 375 HAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIP-KRMVELKEMVSDV 433 Query: 974 HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 LS NKL I E+ L+ LT LD+ N L S P EM L ++ + L Sbjct: 434 DLSFNKLSFISLELCVLQKLTFLDLRNNF-LNSLPEEMESLVRLQTINL 481 Score = 57.0 bits (136), Expect = 4e-07 Identities = 45/168 (26%), Positives = 85/168 (50%), Gaps = 8/168 (4%) Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKE 853 P V D VK + N S NQL +P+ + ++ E + + L NK+S I L L++ Sbjct: 394 PDEVFD-AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQK 452 Query: 854 LKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSC 910 L L+L N ++SL E +E+ ++++ + N +P + ++ + +S N+ Sbjct: 453 LTFLDLRNNFLNSLPEE-MESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 511 Query: 911 I-PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISI 957 + P+ + + +L +LD+ +ND+ +P P +NLR LL N + Sbjct: 512 VDPQKMKMMENLTTLDLQNNDLLQIP-PELGNCVNLRTLLLDGNPFRV 558 Score = 51.2 bits (121), Expect = 2e-05 Identities = 53/193 (27%), Positives = 78/193 (40%), Gaps = 49/193 (25%) Query: 756 TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 +L SL L+L SN+ S P+ + +M + +LD + Sbjct: 174 SLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNS------------------------- 208 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875 N L +P L +E LE L L NK+ + LK L++ +N I L L+ Sbjct: 209 NLLETIPPELAG-MESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLK-- 265 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935 +N S+ +L L NK +P+ I+ L L LD+S+NDI LP Sbjct: 266 --------HLN----------SILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 307 Query: 936 ---GPAHWKSLNL 945 G H K L L Sbjct: 308 YSLGNLHLKFLAL 320 Score = 35.4 bits (80), Expect = 1.3 Identities = 61/252 (24%), Positives = 103/252 (40%), Gaps = 23/252 (9%) Query: 608 LLLRRLA-LDVANNSICLGGFCIGKVEPSWLG----PLFPDKTSNLRKQTNIASTLARMV 662 +LLR L LD++NN I + +G + +L PL + + K T R Sbjct: 288 ILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 347 Query: 663 IR----YQMKSAVEEGTASGSDG--NFSEDVLSKFDEW-----TFIPDSSMDSVFAQSDD 711 I+ Q +SA E S+ N + K ++ T IPD D+V +S+ Sbjct: 348 IKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAV--KSNI 405 Query: 712 LDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL-TLKSLTHLDLHSNKF 770 + S + L + + + E D L L S L L+ LT LDL +N Sbjct: 406 VTSINFSKNQLCEIPKRMVELKEMVSDVDLS--FNKLSFISLELCVLQKLTFLDLRNNFL 463 Query: 771 TSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVE 830 S P + + + +++S N ++ + + TL+ +S NQ+ V ++E Sbjct: 464 NSLPEEMESLVRLQTINLSFNRF--KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMME 521 Query: 831 KLEQLILEGNKI 842 L L L+ N + Sbjct: 522 NLTTLDLQNNDL 533 >gi|51094908|gb|EAL24153.1| similar to hypothetical protein 4932412H11 [Homo sapiens] gi|42658047|ref|XP_376648.1| PREDICTED: similar to hypothetical protein 4932412H11 [Homo sapiens] gi|42658502|ref|XP_379887.1| PREDICTED: similar to hypothetical protein 4932412H11 [Homo sapiens] Length = 651 Score = 83.2 bits (204), Expect = 5e-15 Identities = 82/273 (30%), Positives = 134/273 (49%), Gaps = 17/273 (6%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDV---SRNDIGPSVVLDPTVKCPTLKQFNL 813 L ++ L ++N +FPS L C+ NL++ +N + P++K TL+ NL Sbjct: 233 LGNIRQLFFYNNYIENFPSDL---ECLGNLEILSLGKNKLRHIPDTLPSLK--TLRVLNL 287 Query: 814 SYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLSENFL 872 YNQL+ P+ L + KL L L GN IS + +R LK L+ L + N ++ L+ Sbjct: 288 EYNQLTTFPKALC-FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF 346 Query: 873 EACPKVESFSARMNFLAAMPFLPPS---MTILKLSQNKFSCIPEAILNLPHLRSLDMSSN 929 + K++ N L + + + IL L +N IPE I L L +S N Sbjct: 347 QLL-KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDN 405 Query: 930 DIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC 989 + LP H K NLR+L + N + + L + +++++L +S+N ++EIP IG Sbjct: 406 KLTELPKYIH-KLNNLRKLHVNRNNM-LTRLPGELSNMTQLKELDISNNAIREIPRNIGE 463 Query: 990 LENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 L NL SL +YN ++ P + L+ + L L Sbjct: 464 LRNLVSLH-AYNNQISYLPPSLLSLNDLQQLNL 495 Score = 73.6 bits (179), Expect = 4e-12 Identities = 74/270 (27%), Positives = 139/270 (51%), Gaps = 13/270 (4%) Query: 756 TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 +LK+L L+L N+ T+FP L + + +LD++ N I S + + L+ + + Sbjct: 278 SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLI--SSLPKEIRELKNLETLLMDH 335 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874 N+L+F+ + ++ K+++L L NK+ I + +EL+IL L KN + ++ E + Sbjct: 336 NKLTFLAVEIFQLL-KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEK-ISC 393 Query: 875 CPKVESFSARMNFLAAMP-FLPPSMTILKLSQNK---FSCIPEAILNLPHLRSLDMSSND 930 C +E S N L +P ++ + KL N+ + +P + N+ L+ LD+S+N Sbjct: 394 CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMLTRLPGELSNMTQLKELDISNNA 453 Query: 931 IQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCL 990 I+ +P + NL L +NQIS L S + + +++L+LS N L +P I + Sbjct: 454 IREIPRNI-GELRNLVSLHAYNNQISYLPPSLLSL--NDLQQLNLSGNNLTALPSAIYNI 510 Query: 991 ENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020 +L ++ N LR P E+ K +++ + Sbjct: 511 FSLKEINFDDNPLLRP-PVEICKGKQLYTI 539 Score = 73.6 bits (179), Expect = 4e-12 Identities = 79/281 (28%), Positives = 132/281 (46%), Gaps = 23/281 (8%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF 811 ++S L L L L N +S PS + + + L+VS N I S + + ++Q Sbjct: 182 ADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHI--SHIPKEISQLGNIRQL 239 Query: 812 NLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSEN 870 N + P +L + + LE L L NK+ I L LK L++LNL N +++ + Sbjct: 240 FFYNNYIENFPSDL-ECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKA 298 Query: 871 FLEACPKVESFSARMNFLAAMPFLP---PSMTILKLSQNKFSCIPEAILNLPHLRSLDMS 927 L PK+ S N ++++P ++ L + NK + + I L ++ L ++ Sbjct: 299 -LCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLA 357 Query: 928 SNDIQYLPGPAHWKSLNLRELLFSHNQISILD------LSEKAYLWSRVEKLHLSHNKLK 981 N ++ + +H K N REL +I ILD + EK + +E L LS NKL Sbjct: 358 DNKLEVI---SH-KIENFREL-----RILILDKNLLKNIPEKISCCAMLECLSLSDNKLT 408 Query: 982 EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 E+P I L NL L V+ N L P E+ ++++ +L + Sbjct: 409 ELPKYIHKLNNLRKLHVNRNNMLTRLPGELSNMTQLKELDI 449 Score = 35.0 bits (79), Expect = 1.7 Identities = 44/188 (23%), Positives = 76/188 (40%), Gaps = 11/188 (5%) Query: 834 QLILEGNKISGICSPLRLKELKILNLSKNHI-SSLSENFLEACPKVESFSARMNFLAAMP 892 Q LE SG S ++ K L S+ + S++ + + A +NFL+ Sbjct: 62 QNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHET 121 Query: 893 FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSH 952 S + + +Q + + ++++ + +Q P K ++ L Sbjct: 122 VGEVSPQVSEENQKQLGLGADNF-------TVNLEAKGLQEFPKDI-LKIKYVKYLYLDK 173 Query: 953 NQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMG 1012 NQI ++ L +E L L N L +P EI L NL L+VS+N + P E+ Sbjct: 174 NQIKTFQGADSGDLLG-LEILSLQENGLSSLPSEIQLLHNLRILNVSHN-HISHIPKEIS 231 Query: 1013 KLSKIWDL 1020 +L I L Sbjct: 232 QLGNIRQL 239 >gi|56204430|emb|CAI22426.1| OTTHUMP00000065337 [Homo sapiens] gi|56203373|emb|CAI23423.1| OTTHUMP00000065337 [Homo sapiens] gi|55664510|emb|CAH73692.1| OTTHUMP00000065337 [Homo sapiens] gi|55663984|emb|CAH74019.1| OTTHUMP00000065337 [Homo sapiens] gi|55661894|emb|CAH70975.1| OTTHUMP00000065337 [Homo sapiens] Length = 1495 Score = 82.0 bits (201), Expect = 1e-14 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 31/271 (11%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817 ++L L + N ++ P+ + + + LD+S+N + KC T+ S N Sbjct: 74 QALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI--IEASVNP 131 Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 +S +P+ T ++ L QL L + + + RL +L+IL L +NH+ +L ++ Sbjct: 132 ISKLPDGFTQLLN-LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS------ 184 Query: 877 KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 M+ LA + L L N+F +PE + + +LR L M +N +Q LPG Sbjct: 185 --------MHKLA-------QLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 229 Query: 937 PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996 + K L L S N+I +D+ +E L LS N L+++P IG L+ LT+L Sbjct: 230 -SIGKLKMLVYLDMSKNRIETVDMDISG--CEALEDLLLSSNMLQQLPDSIGLLKKLTTL 286 Query: 997 DVSYNLELRSFPNEMGKLSKI--WDLPLDEL 1025 V N +L PN +G LS + +D +EL Sbjct: 287 KVDDN-QLTMLPNTIGNLSLLEEFDCSCNEL 316 Score = 76.6 bits (187), Expect = 5e-13 Identities = 83/330 (25%), Positives = 150/330 (45%), Gaps = 23/330 (6%) Query: 710 DDLDSEGSEGSFLVKKKSNSIS---VGEFYRDAVLQRCSPNLQRHSNSLT--------LK 758 +DL + + + LV K IS V EF + +C ++ N ++ L Sbjct: 84 NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 143 Query: 759 SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818 +LT L L+ P+ ++ + L++ N + + K L++ +L N+ Sbjct: 144 NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL--KTLPKSMHKLAQLERLDLGNNEF 201 Query: 819 SFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPK 877 +PE L D ++ L +L ++ N + + + +LK L L++SKN I ++ + + C Sbjct: 202 GELPEVL-DQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEA 259 Query: 878 VESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 +E N L +P L +T LK+ N+ + +P I NL L D S N+++ L Sbjct: 260 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 319 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994 P + +LR L N + +L + V + L NKL+ +P EIG ++ L Sbjct: 320 PSTIGYLH-SLRTLAVDENFLP--ELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR 376 Query: 995 SLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 L++S N L++ P KL ++ L L + Sbjct: 377 VLNLSDN-RLKNLPFSFTKLKELAALWLSD 405 Score = 57.4 bits (137), Expect = 3e-07 Identities = 60/228 (26%), Positives = 102/228 (44%), Gaps = 30/228 (13%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L L LDL +N+F P L ++ + L + N + V+ K L ++S N Sbjct: 188 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL--QVLPGSIGKLKMLVYLDMSKN 245 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHIS---------S 866 ++ V +++ E LE L+L N + + + L K+L L + N ++ S Sbjct: 246 RIETVDMDISGC-EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 304 Query: 867 LSENFLEACPKVESFSARMNFLAAMP-------FLPP---------SMTILKLSQNKFSC 910 L E F +C ++ES + + +L ++ FLP ++T++ L NK Sbjct: 305 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEF 364 Query: 911 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958 +PE I + LR L++S N ++ LP + K L L S NQ L Sbjct: 365 LPEEIGQMQKLRVLNLSDNRLKNLPF-SFTKLKELAALWLSDNQSKAL 411 >gi|56204429|emb|CAI22425.1| OTTHUMP00000065336 [Homo sapiens] gi|55664509|emb|CAH73691.1| OTTHUMP00000065336 [Homo sapiens] gi|55663983|emb|CAH74018.1| OTTHUMP00000065336 [Homo sapiens] gi|55661893|emb|CAH70974.1| OTTHUMP00000065336 [Homo sapiens] gi|16904383|ref|NP_065845.1| leucine rich repeat containing 7 [Homo sapiens] gi|16755893|gb|AAL28133.1| densin-180 [Homo sapiens] gi|50401129|sp|Q96NW7|LRR7_HUMAN Leucine-rich repeat-containing protein 7 (LAP1 protein) (Densin-180) Length = 1537 Score = 82.0 bits (201), Expect = 1e-14 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 31/271 (11%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817 ++L L + N ++ P+ + + + LD+S+N + KC T+ S N Sbjct: 69 QALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI--IEASVNP 126 Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 +S +P+ T ++ L QL L + + + RL +L+IL L +NH+ +L ++ Sbjct: 127 ISKLPDGFTQLLN-LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS------ 179 Query: 877 KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 M+ LA + L L N+F +PE + + +LR L M +N +Q LPG Sbjct: 180 --------MHKLA-------QLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224 Query: 937 PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996 + K L L S N+I +D+ +E L LS N L+++P IG L+ LT+L Sbjct: 225 -SIGKLKMLVYLDMSKNRIETVDMDISG--CEALEDLLLSSNMLQQLPDSIGLLKKLTTL 281 Query: 997 DVSYNLELRSFPNEMGKLSKI--WDLPLDEL 1025 V N +L PN +G LS + +D +EL Sbjct: 282 KVDDN-QLTMLPNTIGNLSLLEEFDCSCNEL 311 Score = 76.6 bits (187), Expect = 5e-13 Identities = 83/330 (25%), Positives = 150/330 (45%), Gaps = 23/330 (6%) Query: 710 DDLDSEGSEGSFLVKKKSNSIS---VGEFYRDAVLQRCSPNLQRHSNSLT--------LK 758 +DL + + + LV K IS V EF + +C ++ N ++ L Sbjct: 79 NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 138 Query: 759 SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818 +LT L L+ P+ ++ + L++ N + + K L++ +L N+ Sbjct: 139 NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL--KTLPKSMHKLAQLERLDLGNNEF 196 Query: 819 SFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPK 877 +PE L D ++ L +L ++ N + + + +LK L L++SKN I ++ + + C Sbjct: 197 GELPEVL-DQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEA 254 Query: 878 VESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 +E N L +P L +T LK+ N+ + +P I NL L D S N+++ L Sbjct: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994 P + +LR L N + +L + V + L NKL+ +P EIG ++ L Sbjct: 315 PSTIGYLH-SLRTLAVDENFLP--ELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR 371 Query: 995 SLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 L++S N L++ P KL ++ L L + Sbjct: 372 VLNLSDN-RLKNLPFSFTKLKELAALWLSD 400 Score = 57.4 bits (137), Expect = 3e-07 Identities = 60/228 (26%), Positives = 102/228 (44%), Gaps = 30/228 (13%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L L LDL +N+F P L ++ + L + N + V+ K L ++S N Sbjct: 183 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL--QVLPGSIGKLKMLVYLDMSKN 240 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHIS---------S 866 ++ V +++ E LE L+L N + + + L K+L L + N ++ S Sbjct: 241 RIETVDMDISGC-EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299 Query: 867 LSENFLEACPKVESFSARMNFLAAMP-------FLPP---------SMTILKLSQNKFSC 910 L E F +C ++ES + + +L ++ FLP ++T++ L NK Sbjct: 300 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEF 359 Query: 911 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958 +PE I + LR L++S N ++ LP + K L L S NQ L Sbjct: 360 LPEEIGQMQKLRVLNLSDNRLKNLPF-SFTKLKELAALWLSDNQSKAL 406 >gi|51476914|emb|CAH18423.1| hypothetical protein [Homo sapiens] Length = 1530 Score = 82.0 bits (201), Expect = 1e-14 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 31/271 (11%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817 ++L L + N ++ P+ + + + LD+S+N + KC T+ S N Sbjct: 62 QALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI--IEASVNP 119 Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 +S +P+ T ++ L QL L + + + RL +L+IL L +NH+ +L ++ Sbjct: 120 ISKLPDGFTQLLN-LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS------ 172 Query: 877 KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 M+ LA + L L N+F +PE + + +LR L M +N +Q LPG Sbjct: 173 --------MHKLA-------QLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 217 Query: 937 PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996 + K L L S N+I +D+ +E L LS N L+++P IG L+ LT+L Sbjct: 218 -SIGKLKMLVYLDMSKNRIETVDMDISG--CEALEDLLLSSNMLQQLPDSIGLLKKLTTL 274 Query: 997 DVSYNLELRSFPNEMGKLSKI--WDLPLDEL 1025 V N +L PN +G LS + +D +EL Sbjct: 275 KVDDN-QLTMLPNTIGNLSLLEEFDCSCNEL 304 Score = 73.9 bits (180), Expect = 3e-12 Identities = 82/330 (24%), Positives = 149/330 (45%), Gaps = 23/330 (6%) Query: 710 DDLDSEGSEGSFLVKKKSNSIS---VGEFYRDAVLQRCSPNLQRHSNSLT--------LK 758 +DL + + + LV K IS V EF + +C ++ N ++ L Sbjct: 72 NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 131 Query: 759 SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818 +LT L L+ P+ ++ + L++ N + + K L++ +L N+ Sbjct: 132 NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL--KTLPKSMHKLAQLERLDLGNNEF 189 Query: 819 SFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPK 877 +PE L D ++ L +L ++ N + + + +LK L L++SKN I ++ + + C Sbjct: 190 GELPEVL-DQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEA 247 Query: 878 VESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 +E N L +P L +T LK+ N+ + +P I NL L D S N+++ L Sbjct: 248 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 307 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994 P + +LR L N + +L + V + L NKL+ +P EIG ++ L Sbjct: 308 PSTIGYLH-SLRTLAVDENFLP--ELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR 364 Query: 995 SLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 ++S N L++ P KL ++ L L + Sbjct: 365 VPNLSDN-RLKNLPFSFTKLKELAALWLSD 393 Score = 54.7 bits (130), Expect = 2e-06 Identities = 59/228 (25%), Positives = 101/228 (44%), Gaps = 30/228 (13%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L L LDL +N+F P L ++ + L + N + V+ K L ++S N Sbjct: 176 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL--QVLPGSIGKLKMLVYLDMSKN 233 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHIS---------S 866 ++ V +++ E LE L+L N + + + L K+L L + N ++ S Sbjct: 234 RIETVDMDISGC-EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 292 Query: 867 LSENFLEACPKVESFSARMNFLAAMP-------FLPP---------SMTILKLSQNKFSC 910 L E F +C ++ES + + +L ++ FLP ++T++ L NK Sbjct: 293 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEF 352 Query: 911 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958 +PE I + LR ++S N ++ LP + K L L S NQ L Sbjct: 353 LPEEIGQMQKLRVPNLSDNRLKNLPF-SFTKLKELAALWLSDNQSKAL 399 >gi|29791785|gb|AAH50692.1| ERBB2IP protein [Homo sapiens] Length = 633 Score = 81.3 bits (199), Expect = 2e-14 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%) Query: 735 FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794 + DA L+ N R L L L+L N+ P + +++ + LD+ N+ Sbjct: 144 YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854 + V + + LK+F + N+L+F+P + LK+L Sbjct: 197 -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232 Query: 855 KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911 L++SKN+I + E + C ++ N L +P S+ T LK+ +N+ + Sbjct: 233 TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291 Query: 912 PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971 P++I L + LD S N+++ LP + + NLR HN + L + W + Sbjct: 292 PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017 L L NKL+ +P E+G ++ L +++S N L++ P KL ++ Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393 Score = 79.3 bits (194), Expect = 8e-14 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817 +SL L L N T+ P+ + + + LDVS+N G + C L S N Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126 Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 +S +P+ + ++ L QL L + + + RL +L+IL L +N + L + + Sbjct: 127 ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184 Query: 877 KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933 ++E N +P + ++ LK + N+ + IP I +L L LD+S N+I+ Sbjct: 185 QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993 + NL++LL S N S+ L E + L + N+L +P IG L ++ Sbjct: 245 VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053 LD S+N E+ + P+ +G+L+ + D +L IG + FL + + Sbjct: 302 EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 Query: 1054 P 1054 P Sbjct: 361 P 361 Score = 60.8 bits (146), Expect = 3e-08 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849 T+ + S+ L VP+ + + LE+L L+ N+I + C L Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 Query: 850 -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892 L L+ L++SKN I EN ++ C + A +N ++ +P Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 Query: 893 ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 FLP + + IL+L +N+ +P+ + L L LD+ SN+ +P Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201 Query: 937 --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976 W N + + S Q++ LD+S E ++ L LS Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261 Query: 977 HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020 N L+++P IG L+N+T+L + N +L P+ +G L + +L Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304 Score = 42.4 bits (98), Expect = 0.011 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%) Query: 846 CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 C LR +E + L +H S LE PK E F+ ++ L L Sbjct: 14 CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 N+ +P+ + N L L + ND+ LP +NLREL S N I + E Sbjct: 56 NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025 + + S N + ++P L NLT L ++ + L P G+L+K+ L L E Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171 Query: 1026 HL 1027 L Sbjct: 172 QL 173 >gi|55770895|ref|NP_001006600.1| ERBB2 interacting protein isoform 7; densin-180-like protein; ERBB2-interacting protein [Homo sapiens] Length = 1302 Score = 81.3 bits (199), Expect = 2e-14 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%) Query: 735 FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794 + DA L+ N R L L L+L N+ P + +++ + LD+ N+ Sbjct: 144 YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854 + V + + LK+F + N+L+F+P + LK+L Sbjct: 197 -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232 Query: 855 KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911 L++SKN+I + E + C ++ N L +P S+ T LK+ +N+ + Sbjct: 233 TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291 Query: 912 PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971 P++I L + LD S N+++ LP + + NLR HN + L + W + Sbjct: 292 PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017 L L NKL+ +P E+G ++ L +++S N L++ P KL ++ Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393 Score = 79.3 bits (194), Expect = 8e-14 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817 +SL L L N T+ P+ + + + LDVS+N G + C L S N Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126 Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 +S +P+ + ++ L QL L + + + RL +L+IL L +N + L + + Sbjct: 127 ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184 Query: 877 KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933 ++E N +P + ++ LK + N+ + IP I +L L LD+S N+I+ Sbjct: 185 QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993 + NL++LL S N S+ L E + L + N+L +P IG L ++ Sbjct: 245 VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053 LD S+N E+ + P+ +G+L+ + D +L IG + FL + + Sbjct: 302 EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 Query: 1054 P 1054 P Sbjct: 361 P 361 Score = 60.8 bits (146), Expect = 3e-08 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849 T+ + S+ L VP+ + + LE+L L+ N+I + C L Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 Query: 850 -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892 L L+ L++SKN I EN ++ C + A +N ++ +P Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 Query: 893 ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 FLP + + IL+L +N+ +P+ + L L LD+ SN+ +P Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201 Query: 937 --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976 W N + + S Q++ LD+S E ++ L LS Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261 Query: 977 HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020 N L+++P IG L+N+T+L + N +L P+ +G L + +L Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304 Score = 42.4 bits (98), Expect = 0.011 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%) Query: 846 CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 C LR +E + L +H S LE PK E F+ ++ L L Sbjct: 14 CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 N+ +P+ + N L L + ND+ LP +NLREL S N I + E Sbjct: 56 NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025 + + S N + ++P L NLT L ++ + L P G+L+K+ L L E Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171 Query: 1026 HL 1027 L Sbjct: 172 QL 173 >gi|8923909|ref|NP_061165.1| ERBB2 interacting protein isoform 2 [Homo sapiens] gi|8572221|gb|AAF77048.1| erbb2-interacting protein ERBIN [Homo sapiens] gi|20521800|dbj|BAA86539.2| KIAA1225 protein [Homo sapiens] Length = 1371 Score = 81.3 bits (199), Expect = 2e-14 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%) Query: 735 FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794 + DA L+ N R L L L+L N+ P + +++ + LD+ N+ Sbjct: 144 YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854 + V + + LK+F + N+L+F+P + LK+L Sbjct: 197 -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232 Query: 855 KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911 L++SKN+I + E + C ++ N L +P S+ T LK+ +N+ + Sbjct: 233 TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291 Query: 912 PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971 P++I L + LD S N+++ LP + + NLR HN + L + W + Sbjct: 292 PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017 L L NKL+ +P E+G ++ L +++S N L++ P KL ++ Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393 Score = 79.3 bits (194), Expect = 8e-14 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817 +SL L L N T+ P+ + + + LDVS+N G + C L S N Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126 Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 +S +P+ + ++ L QL L + + + RL +L+IL L +N + L + + Sbjct: 127 ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184 Query: 877 KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933 ++E N +P + ++ LK + N+ + IP I +L L LD+S N+I+ Sbjct: 185 QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993 + NL++LL S N S+ L E + L + N+L +P IG L ++ Sbjct: 245 VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053 LD S+N E+ + P+ +G+L+ + D +L IG + FL + + Sbjct: 302 EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 Query: 1054 P 1054 P Sbjct: 361 P 361 Score = 60.8 bits (146), Expect = 3e-08 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849 T+ + S+ L VP+ + + LE+L L+ N+I + C L Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 Query: 850 -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892 L L+ L++SKN I EN ++ C + A +N ++ +P Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 Query: 893 ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 FLP + + IL+L +N+ +P+ + L L LD+ SN+ +P Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201 Query: 937 --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976 W N + + S Q++ LD+S E ++ L LS Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261 Query: 977 HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020 N L+++P IG L+N+T+L + N +L P+ +G L + +L Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304 Score = 42.4 bits (98), Expect = 0.011 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%) Query: 846 CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 C LR +E + L +H S LE PK E F+ ++ L L Sbjct: 14 CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 N+ +P+ + N L L + ND+ LP +NLREL S N I + E Sbjct: 56 NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025 + + S N + ++P L NLT L ++ + L P G+L+K+ L L E Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171 Query: 1026 HL 1027 L Sbjct: 172 QL 173 >gi|14582259|gb|AAK69431.1| densin-180-like protein [Homo sapiens] gi|50401131|sp|Q96RT1|LAP2_HUMAN LAP2 protein (Erbb2-interacting protein) (Erbin) (Densin-180-like protein) Length = 1412 Score = 81.3 bits (199), Expect = 2e-14 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%) Query: 735 FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794 + DA L+ N R L L L+L N+ P + +++ + LD+ N+ Sbjct: 144 YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854 + V + + LK+F + N+L+F+P + LK+L Sbjct: 197 -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232 Query: 855 KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911 L++SKN+I + E + C ++ N L +P S+ T LK+ +N+ + Sbjct: 233 TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291 Query: 912 PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971 P++I L + LD S N+++ LP + + NLR HN + L + W + Sbjct: 292 PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017 L L NKL+ +P E+G ++ L +++S N L++ P KL ++ Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393 Score = 79.3 bits (194), Expect = 8e-14 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817 +SL L L N T+ P+ + + + LDVS+N G + C L S N Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126 Query: 818 LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876 +S +P+ + ++ L QL L + + + RL +L+IL L +N + L + + Sbjct: 127 ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184 Query: 877 KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933 ++E N +P + ++ LK + N+ + IP I +L L LD+S N+I+ Sbjct: 185 QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993 + NL++LL S N S+ L E + L + N+L +P IG L ++ Sbjct: 245 VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053 LD S+N E+ + P+ +G+L+ + D +L IG + FL + + Sbjct: 302 EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360 Query: 1054 P 1054 P Sbjct: 361 P 361 Score = 60.8 bits (146), Expect = 3e-08 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849 T+ + S+ L VP+ + + LE+L L+ N+I + C L Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82 Query: 850 -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892 L L+ L++SKN I EN ++ C + A +N ++ +P Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141 Query: 893 ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 FLP + + IL+L +N+ +P+ + L L LD+ SN+ +P Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201 Query: 937 --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976 W N + + S Q++ LD+S E ++ L LS Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261 Query: 977 HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020 N L+++P IG L+N+T+L + N +L P+ +G L + +L Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304 Score = 42.4 bits (98), Expect = 0.011 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%) Query: 846 CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 C LR +E + L +H S LE PK E F+ ++ L L Sbjct: 14 CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 N+ +P+ + N L L + ND+ LP +NLREL S N I + E Sbjct: 56 NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025 + + S N + ++P L NLT L ++ + L P G+L+K+ L L E Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171 Query: 1026 HL 1027 L Sbjct: 172 QL 173 >gi|13112035|gb|AAH03193.1| LRRC1 protein [Homo sapiens] gi|55960464|emb|CAI17358.1| OTTHUMP00000039963 [Homo sapiens] gi|56202741|emb|CAI21666.1| OTTHUMP00000039963 [Homo sapiens] gi|14701834|gb|AAK72246.1| LANO adaptor protein [Homo sapiens] gi|14582756|gb|AAK69623.1| leucine-rich repeats protein [Homo sapiens] gi|50401149|sp|Q9BTT6|LRR1_HUMAN Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein) Length = 524 Score = 80.1 bits (196), Expect = 5e-14 Identities = 79/248 (31%), Positives = 122/248 (49%), Gaps = 11/248 (4%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHIS 865 +L++ L NQL +PE +V KL +L L N+I + + +L L++S+N I Sbjct: 37 SLEELLLDANQLRELPEQFFQLV-KLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIP 95 Query: 866 SLSENFLEACPKVESFSARMNFLAAMPFLPP---SMTILKLSQNKFSCIPEAILNLPHLR 922 + E+ + C ++ N L +P P ++T L ++ +PE I NL +L Sbjct: 96 EIPES-ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLA 154 Query: 923 SLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKE 982 SL++ N + YLP + L EL +N+I L S A L ++ L L N+L E Sbjct: 155 SLELRENLLTYLPDSLT-QLRRLEELDLGNNEIYNLPESIGALL--HLKDLWLDGNQLSE 211 Query: 983 IPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIG-CKAKDI 1041 +P EIG L+NL LDVS N L P E+ L+ + DL + + L IG K I Sbjct: 212 LPQEIGNLKNLLCLDVSEN-RLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSI 270 Query: 1042 IRFLQQRL 1049 ++ Q RL Sbjct: 271 LKVDQNRL 278 Score = 71.2 bits (173), Expect = 2e-11 Identities = 71/271 (26%), Positives = 121/271 (44%), Gaps = 50/271 (18%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L L L L N+ P + + LDVSRN+I + + C L+ + S N Sbjct: 58 LVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEI--PEIPESISFCKALQVADFSGN 115 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACP 876 L+ +PE+ + L+ L L+++ + SL EN Sbjct: 116 PLTRLPESFPE-----------------------LQNLTCLSVNDISLQSLPENI----- 147 Query: 877 KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 + LA+ L+L +N + +P+++ L L LD+ +N+I LP Sbjct: 148 ------GNLYNLAS----------LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP- 190 Query: 937 PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996 + L+L++L NQ+S +L ++ + L +S N+L+ +P EI L +LT L Sbjct: 191 ESIGALLHLKDLWLDGNQLS--ELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDL 248 Query: 997 DVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027 +S NL L + P+ +GKL K+ L +D+ L Sbjct: 249 VISQNL-LETIPDGIGKLKKLSILKVDQNRL 278 Score = 61.2 bits (147), Expect = 2e-08 Identities = 65/270 (24%), Positives = 127/270 (47%), Gaps = 18/270 (6%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L++LT L ++ S P + + +A+L++ N + + + D + L++ +L N Sbjct: 127 LQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLL--TYLPDSLTQLRRLEELDLGNN 184 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875 ++ +PE++ ++ L+ L L+GN++S + + LK L L++S+N + L E + Sbjct: 185 EIYNLPESIGALLH-LKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGL 242 Query: 876 PKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQ 932 + N L +P ++ILK+ QN+ + +PEA+ L L ++ N + Sbjct: 243 TSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLL 302 Query: 933 YLPGPAHWKSLNLRELLFSHN--QISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCL 990 LP KS+ + L + N + ++ L ++ + + N+L IP E+ Sbjct: 303 TLP-----KSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQA 357 Query: 991 ENLTSLDVSYNLELRSFPNEMG--KLSKIW 1018 L LDV+ N L P + KL +W Sbjct: 358 TELHVLDVAGN-RLLHLPLSLTALKLKALW 386 Score = 55.8 bits (133), Expect = 9e-07 Identities = 53/185 (28%), Positives = 86/185 (46%), Gaps = 10/185 (5%) Query: 908 FSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLW 967 F CIP N H+ S+D + Y+P + + +L ELL NQ+ +L E+ + Sbjct: 2 FHCIPLWRCNR-HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLR--ELPEQFFQL 58 Query: 968 SRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMG--KLSKIWDL---PL 1022 ++ KL LS N+++ +PPEI L LDVS N E+ P + K ++ D PL Sbjct: 59 VKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRN-EIPEIPESISFCKALQVADFSGNPL 117 Query: 1023 DELHLNF-DFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTK 1081 L +F + +++ C + + I YN L + N + L QL + + Sbjct: 118 TRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLE 177 Query: 1082 KSDLG 1086 + DLG Sbjct: 178 ELDLG 182 >gi|37221175|ref|NP_919431.1| suprachiasmatic nucleus circadian oscillatory protein [Homo sapiens] Length = 1205 Score = 79.7 bits (195), Expect = 6e-14 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 +K L++L L N+FT P L K++ + L +S N + ++ L K P +K +L N Sbjct: 247 MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 305 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874 + + + D ++ + QL L NK+ G + +++L+ +N + +L FL+A Sbjct: 306 VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 364 Query: 875 CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 + + S + L P +P ++ + +S+N+ +PE + L LD+ N I L Sbjct: 365 ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993 P S +LR+LL HNQ++ L E+ S VE L + HN+L E+PP + ++L Sbjct: 421 PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 476 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027 L+ S N +L S P LS+ + L EL+L Sbjct: 477 RFLNASAN-KLESLP--PATLSEETNSILQELYL 507 Score = 45.4 bits (106), Expect = 0.001 Identities = 57/215 (26%), Positives = 88/215 (40%), Gaps = 31/215 (14%) Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 SL L+ +NK S P L S + L ++ N + V T P LK +++Y Sbjct: 475 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 533 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875 N+L P + +E+LE++ L GNK+ I I+N + H N +E Sbjct: 534 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCRRMHTVIAHSNCIEVF 586 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933 P+V P + + LS N+ S +PE + P L+ LD++ N Sbjct: 587 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 630 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968 L N+R F +Q S D S +WS Sbjct: 631 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 663 Score = 45.4 bits (106), Expect = 0.001 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%) Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827 FT + +L ++S +A+ +S D+ C +L+ NL Y+Q +LT Sbjct: 109 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 152 Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868 + L+Q L N G+ R +LK LNLS NH+ ++S Sbjct: 153 L--NLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 210 Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918 N L + P +++F NFL ++P +M + L LS N+F+ IPE + L Sbjct: 211 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 270 Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978 + L MS N ++ L A K +++ + N I L E +L V +L L N Sbjct: 271 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 329 Query: 979 KLKEI 983 KL ++ Sbjct: 330 KLGDL 334 Score = 37.0 bits (84), Expect = 0.45 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809 S L+ L +DL NK + P+ ++ + + N ++ P V+ P +KC Sbjct: 542 SKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC---- 597 Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840 +LS N+LS V PENL KL++L L GN Sbjct: 598 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 626 >gi|422993|pir||JU0229 mixed-lineage protein kinase 1 - human gi|462606|sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 (Mixed lineage kinase 1) gi|299825|gb|AAB26359.1| mixed-lineage kinase 1, MLK1=epithelial protein kinase [human, Colo 16 cell line, Peptide, 394 aa] Length = 394 Score = 79.7 bits (195), Expect = 6e-14 Identities = 63/200 (31%), Positives = 103/200 (51%), Gaps = 18/200 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639 LVME A G L+R+L + + + A+ +A G+ YLH I I+RDLK N+L Sbjct: 77 LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 134 Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696 + N + I KI D+G+A+ R ++ GT + APEV R + ++++ +DV+S Sbjct: 135 ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 193 Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754 +G+LL+++LT R ++GL+ KL P+ P P KL++ C Sbjct: 194 YGVLLWELLTGEVPFRGIDGLRVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 246 Query: 1755 ENPQERPTSAQVFDILNSAE 1774 +P RP+ + D L + E Sbjct: 247 PDPHSRPSFTNILDQLTTIE 266 >gi|34809548|gb|AAH14927.2| PLEKHE1 protein [Homo sapiens] Length = 1227 Score = 79.7 bits (195), Expect = 6e-14 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 +K L++L L N+FT P L K++ + L +S N + ++ L K P +K +L N Sbjct: 269 MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 327 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874 + + + D ++ + QL L NK+ G + +++L+ +N + +L FL+A Sbjct: 328 VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 386 Query: 875 CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 + + S + L P +P ++ + +S+N+ +PE + L LD+ N I L Sbjct: 387 ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 442 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993 P S +LR+LL HNQ++ L E+ S VE L + HN+L E+PP + ++L Sbjct: 443 PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 498 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027 L+ S N +L S P LS+ + L EL+L Sbjct: 499 RFLNASAN-KLESLP--PATLSEETNSILQELYL 529 Score = 45.4 bits (106), Expect = 0.001 Identities = 57/215 (26%), Positives = 88/215 (40%), Gaps = 31/215 (14%) Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 SL L+ +NK S P L S + L ++ N + V T P LK +++Y Sbjct: 497 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 555 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875 N+L P + +E+LE++ L GNK+ I I+N + H N +E Sbjct: 556 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCRRMHTVIAHSNCIEVF 608 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933 P+V P + + LS N+ S +PE + P L+ LD++ N Sbjct: 609 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 652 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968 L N+R F +Q S D S +WS Sbjct: 653 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 685 Score = 45.4 bits (106), Expect = 0.001 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%) Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827 FT + +L ++S +A+ +S D+ C +L+ NL Y+Q +LT Sbjct: 131 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 174 Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868 + L+Q L N G+ R +LK LNLS NH+ ++S Sbjct: 175 L--NLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 232 Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918 N L + P +++F NFL ++P +M + L LS N+F+ IPE + L Sbjct: 233 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 292 Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978 + L MS N ++ L A K +++ + N I L E +L V +L L N Sbjct: 293 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 351 Query: 979 KLKEI 983 KL ++ Sbjct: 352 KLGDL 356 Score = 37.0 bits (84), Expect = 0.45 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809 S L+ L +DL NK + P+ ++ + + N ++ P V+ P +KC Sbjct: 564 SKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC---- 619 Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840 +LS N+LS V PENL KL++L L GN Sbjct: 620 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 648 >gi|7023489|dbj|BAA91980.1| unnamed protein product [Homo sapiens] Length = 721 Score = 79.7 bits (195), Expect = 6e-14 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 +K L++L L N+FT P L K++ + L +S N + ++ L K P +K +L N Sbjct: 247 MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 305 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874 + + + D ++ + QL L NK+ G + +++L+ +N + +L FL+A Sbjct: 306 VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 364 Query: 875 CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 + + S + L P +P ++ + +S+N+ +PE + L LD+ N I L Sbjct: 365 ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993 P S +LR+LL HNQ++ L E+ S VE L + HN+L E+PP + ++L Sbjct: 421 PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 476 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027 L+ S N +L S P LS+ + L EL+L Sbjct: 477 RFLNASAN-KLESLP--PATLSEETNSILQELYL 507 Score = 45.4 bits (106), Expect = 0.001 Identities = 57/215 (26%), Positives = 88/215 (40%), Gaps = 31/215 (14%) Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 SL L+ +NK S P L S + L ++ N + V T P LK +++Y Sbjct: 475 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 533 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875 N+L P + +E+LE++ L GNK+ I I+N + H N +E Sbjct: 534 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCRRMHTVIAHSNCIEVF 586 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933 P+V P + + LS N+ S +PE + P L+ LD++ N Sbjct: 587 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 630 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968 L N+R F +Q S D S +WS Sbjct: 631 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 663 Score = 45.4 bits (106), Expect = 0.001 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%) Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827 FT + +L ++S +A+ +S D+ C +L+ NL Y+Q +LT Sbjct: 109 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 152 Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868 + L+Q L N G+ R +LK LNLS NH+ ++S Sbjct: 153 L--NLKQNFLRQNPSLPAARGLNELQRFAKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 210 Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918 N L + P +++F NFL ++P +M + L LS N+F+ IPE + L Sbjct: 211 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 270 Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978 + L MS N ++ L A K +++ + N I L E +L V +L L N Sbjct: 271 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 329 Query: 979 KLKEI 983 KL ++ Sbjct: 330 KLGDL 334 Score = 37.0 bits (84), Expect = 0.45 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809 S L+ L +DL NK + P+ ++ + + N ++ P V+ P +KC Sbjct: 542 SKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC---- 597 Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840 +LS N+LS V PENL KL++L L GN Sbjct: 598 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 626 >gi|20521103|dbj|BAA25532.2| KIAA0606 protein [Homo sapiens] Length = 1369 Score = 79.7 bits (195), Expect = 6e-14 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 +K L++L L N+FT P L K++ + L +S N + ++ L K P +K +L N Sbjct: 411 MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 469 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874 + + + D ++ + QL L NK+ G + +++L+ +N + +L FL+A Sbjct: 470 VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 528 Query: 875 CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 + + S + L P +P ++ + +S+N+ +PE + L LD+ N I L Sbjct: 529 ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 584 Query: 935 PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993 P S +LR+LL HNQ++ L E+ S VE L + HN+L E+PP + ++L Sbjct: 585 PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 640 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027 L+ S N +L S P LS+ + L EL+L Sbjct: 641 RFLNASAN-KLESLP--PATLSEETNSILQELYL 671 Score = 47.4 bits (111), Expect = 3e-04 Identities = 58/215 (26%), Positives = 89/215 (41%), Gaps = 31/215 (14%) Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815 SL L+ +NK S P L S + L ++ N + V T P LK +++Y Sbjct: 639 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 697 Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875 N+L P + +E+LE++ L GNK+ I I+N S+ H N +E Sbjct: 698 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCSRMHTVIAHSNCIEVF 750 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933 P+V P + + LS N+ S +PE + P L+ LD++ N Sbjct: 751 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 794 Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968 L N+R F +Q S D S +WS Sbjct: 795 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 827 Score = 45.4 bits (106), Expect = 0.001 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%) Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827 FT + +L ++S +A+ +S D+ C +L+ NL Y+Q +LT Sbjct: 273 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 316 Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868 + L+Q L N G+ R +LK LNLS NH+ ++S Sbjct: 317 L--NLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 374 Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918 N L + P +++F NFL ++P +M + L LS N+F+ IPE + L Sbjct: 375 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 434 Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978 + L MS N ++ L A K +++ + N I L E +L V +L L N Sbjct: 435 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 493 Query: 979 KLKEI 983 KL ++ Sbjct: 494 KLGDL 498 Score = 38.9 bits (89), Expect = 0.12 Identities = 31/93 (33%), Positives = 47/93 (50%), Gaps = 12/93 (12%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809 S L+ L +DL NK + P+ ++ S + + N ++ P V+ P +KC Sbjct: 706 SKMAKLEELEEIDLSGNKLKAIPTTIMNCSRMHTVIAHSNCIEVFPEVMQLPEIKC---- 761 Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840 +LS N+LS V PENL KL++L L GN Sbjct: 762 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 790 >gi|52421790|ref|NP_149132.2| mitogen-activated protein kinase kinase kinase 9 [Homo sapiens] Length = 1118 Score = 78.6 bits (192), Expect = 1e-13 Identities = 63/200 (31%), Positives = 102/200 (51%), Gaps = 18/200 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639 LVME A G L+R+L + + + A+ +A G+ YLH I I+RDLK N+L Sbjct: 218 LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 275 Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696 + N + I KI D+G+A+ R ++ GT + APEV R + ++++ +DV+S Sbjct: 276 ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 334 Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754 +G+LL+++LT R ++GL KL P+ P P KL++ C Sbjct: 335 YGVLLWELLTGEVPFRGIDGLAVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 387 Query: 1755 ENPQERPTSAQVFDILNSAE 1774 +P RP+ + D L + E Sbjct: 388 PDPHSRPSFTNILDQLTTIE 407 >gi|33591094|gb|AAQ23054.1| mixed-lineage protein kinase 1 [Homo sapiens] Length = 1104 Score = 78.6 bits (192), Expect = 1e-13 Identities = 63/200 (31%), Positives = 102/200 (51%), Gaps = 18/200 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639 LVME A G L+R+L + + + A+ +A G+ YLH I I+RDLK N+L Sbjct: 218 LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 275 Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696 + N + I KI D+G+A+ R ++ GT + APEV R + ++++ +DV+S Sbjct: 276 ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 334 Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754 +G+LL+++LT R ++GL KL P+ P P KL++ C Sbjct: 335 YGVLLWELLTGEVPFRGIDGLAVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 387 Query: 1755 ENPQERPTSAQVFDILNSAE 1774 +P RP+ + D L + E Sbjct: 388 PDPHSRPSFTNILDQLTTIE 407 >gi|12005724|gb|AAG44591.1| mixed lineage kinase MLK1 [Homo sapiens] Length = 1066 Score = 78.6 bits (192), Expect = 1e-13 Identities = 63/200 (31%), Positives = 102/200 (51%), Gaps = 18/200 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639 LVME A G L+R+L + + + A+ +A G+ YLH I I+RDLK N+L Sbjct: 166 LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 223 Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696 + N + I KI D+G+A+ R ++ GT + APEV R + ++++ +DV+S Sbjct: 224 ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 282 Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754 +G+LL+++LT R ++GL KL P+ P P KL++ C Sbjct: 283 YGVLLWELLTGEVPFRGIDGLAVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 335 Query: 1755 ENPQERPTSAQVFDILNSAE 1774 +P RP+ + D L + E Sbjct: 336 PDPHSRPSFTNILDQLTTIE 355 >gi|21450844|ref|NP_647611.1| megakaryocyte-associated tyrosine kinase isoform c [Homo sapiens] gi|57997093|emb|CAB70906.2| hypothetical protein [Homo sapiens] Length = 466 Score = 77.4 bits (189), Expect = 3e-13 Identities = 55/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VME SKG+L L+ +L T Q + +LHVA+G+ YL S +++RDL N+L+ Sbjct: 261 IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 319 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 + ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+LL Sbjct: 320 ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 373 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 +++ + G + + +E ++ P GC P P V L+ C + P RP Sbjct: 374 WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 428 >gi|21450846|ref|NP_647612.1| megakaryocyte-associated tyrosine kinase isoform a [Homo sapiens] gi|12652729|gb|AAH00114.1| Megakaryocyte-associated tyrosine kinase, isoform a [Homo sapiens] gi|13111883|gb|AAH03109.1| Megakaryocyte-associated tyrosine kinase, isoform a [Homo sapiens] gi|896220|gb|AAC60645.1| megakaryocyte-associated tyrosine kinase [Homo sapiens] gi|1082751|pir||A55625 protein-tyrosine kinase (EC 2.7.1.112) matk, short splice form - human gi|3702304|gb|AAC62843.1| MATK_HUMAN; TYROSINE-PROTEIN KINASE CTK; PROTEIN KINASE HYL; HEMATOPOIETIC CONSENSUS TYROSINE-LACKING KINASE [Homo sapiens] gi|1169123|sp|P42679|MATK_HUMAN Megakaryocyte-associated tyrosine-protein kinase (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) gi|557272|emb|CAA54493.1| HYL tyrosine kinase [Homo sapiens] Length = 507 Score = 77.4 bits (189), Expect = 3e-13 Identities = 55/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VME SKG+L L+ +L T Q + +LHVA+G+ YL S +++RDL N+L+ Sbjct: 302 IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 360 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 + ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+LL Sbjct: 361 ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 414 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 +++ + G + + +E ++ P GC P P V L+ C + P RP Sbjct: 415 WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 469 >gi|21450842|ref|NP_002369.2| megakaryocyte-associated tyrosine kinase isoform b [Homo sapiens] Length = 508 Score = 77.4 bits (189), Expect = 3e-13 Identities = 55/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VME SKG+L L+ +L T Q + +LHVA+G+ YL S +++RDL N+L+ Sbjct: 303 IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 361 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 + ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+LL Sbjct: 362 ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 415 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 +++ + G + + +E ++ P GC P P V L+ C + P RP Sbjct: 416 WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 470 >gi|559594|gb|AAB30995.1| leukocyte carboxyl-terminal src kinase related gene [Homo sapiens] Length = 465 Score = 77.0 bits (188), Expect = 4e-13 Identities = 54/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VME SKG+L L+ +L T Q + +LHV +G+ YL S +++RDL N+L+ Sbjct: 260 IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVREGMEYLESKKLVHRDLAARNILV- 318 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 + ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+LL Sbjct: 319 ----SEELVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 372 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 +++ + G + + +E + ++ P GC P P V L+ C + P RP Sbjct: 373 WEVFSYGRAPYPKMSLKEVSEAVEKRYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 427 >gi|14916455|ref|NP_149117.1| protein serine kinase H2 [Homo sapiens] gi|14346040|gb|AAK59985.1| serine/threonine kinase PSKH2 [Homo sapiens] Length = 385 Score = 75.5 bits (184), Expect = 1e-12 Identities = 60/172 (34%), Positives = 87/172 (50%), Gaps = 16/172 (9%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VMELA+ G L DRL+ Q S T RI VADG+RYLH+ I +R+LKP N+L + Sbjct: 135 MVMELATGGELFDRLIAQ--GSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYY 192 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG---IKTSEGTPGFRAPEVARGNVIYNQQADVYSFG 1698 +P I D+G+A + G +KT GTP + APEV Y D+++ G Sbjct: 193 --HPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKP-YTSAVDMWALG 249 Query: 1699 LLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++ Y +L+ L F +E + + K+ Y PWP + L K Sbjct: 250 VITYALLS------GFLPFDDE-SQTRLYRKILKGKYNYTGEPWPSISHLAK 294 >gi|55958775|emb|CAI16469.1| fyn-related kinase [Homo sapiens] gi|56203498|emb|CAB87592.2| fyn-related kinase [Homo sapiens] gi|4503787|ref|NP_002022.1| fyn-related kinase [Homo sapiens] gi|15277744|gb|AAH12916.1| Fyn-related kinase [Homo sapiens] gi|2117802|pir||I38396 protein-tyrosine kinase (EC 2.7.1.112) FRK - human gi|1169745|sp|P42685|FRK_HUMAN Tyrosine-protein kinase FRK (Nuclear tyrosine protein kinase RAK) gi|741031|prf||2006289A src-like Tyr kinase gi|392888|gb|AAA18284.1| SRC-like tyrosine kinase Length = 505 Score = 75.1 bits (183), Expect = 1e-12 Identities = 64/193 (33%), Positives = 90/193 (46%), Gaps = 24/193 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P ++ EL GSL LQ D S + T Q +A VA G+ YL S I+RDL NV Sbjct: 301 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 360 Query: 1639 LLFTLYPNAAIIAKIADYGIAQ---------YCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689 L+ I K+AD+G+A+ Y R IK + APE R N ++ Sbjct: 361 LV-----GEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK---WTAPEAIRSNK-FS 411 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LLY+I+T G G+ L +LP P C ++ Sbjct: 412 IKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP---SNCP--QQFYNIM 466 Query: 1750 KQCLKENPQERPT 1762 +C P+ERPT Sbjct: 467 LECWNAEPKERPT 479 >gi|54696178|gb|AAV38461.1| mitogen-activated protein kinase kinase kinase 7 [Homo sapiens] Length = 606 Score = 75.1 bits (183), Expect = 1e-12 Identities = 63/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630 A + P LVME A GSL +L + T H ++ L + G+ YLHS +I+ Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RDLKP N+LL + KI D+G A C + + ++G+ + APEV G+ YN Sbjct: 155 RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YN 207 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739 ++ DV+S+G++L++++T FDE+ G P +K Sbjct: 208 EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254 Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770 P P +E L+ +C ++P +RP+ ++ I+ Sbjct: 255 LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284 >gi|732528|gb|AAC50116.1| Rak Length = 505 Score = 75.1 bits (183), Expect = 1e-12 Identities = 64/193 (33%), Positives = 90/193 (46%), Gaps = 24/193 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P ++ EL GSL LQ D S + T Q +A VA G+ YL S I+RDL NV Sbjct: 301 PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 360 Query: 1639 LLFTLYPNAAIIAKIADYGIAQ---------YCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689 L+ I K+AD+G+A+ Y R IK + APE R N ++ Sbjct: 361 LV-----GEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK---WTAPEAIRSNK-FS 411 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LLY+I+T G G+ L +LP P C ++ Sbjct: 412 IKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP---SNCP--QQFYNIM 466 Query: 1750 KQCLKENPQERPT 1762 +C P+ERPT Sbjct: 467 LECWNAEPKERPT 479 >gi|29124496|gb|AAH48960.1| Viral oncogene yes-1 homolog 1 [Homo sapiens] gi|4885661|ref|NP_005424.1| viral oncogene yes-1 homolog 1 [Homo sapiens] gi|66799|pir||TVHUYS protein-tyrosine kinase (EC 2.7.1.112) yes-1 - human gi|125870|sp|P07947|YES_HUMAN Proto-oncogene tyrosine-protein kinase YES (p61-YES) (C-YES) gi|181268|gb|AAA35735.1| cellular yes-1 protein Length = 543 Score = 74.3 bits (181), Expect = 3e-12 Identities = 67/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%) Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597 T+ + P+ L + L +D+L P + + P +V E SKGSL D L Sbjct: 306 TLKPGTMMPEAFLQEAQIMKKLRHDKL----VPLYAVVSEEPIYIVTEFMSKGSLLDFLK 361 Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657 + D L +A +ADG+ Y+ I+RDL+ N+L+ ++ KIAD+G Sbjct: 362 EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-----GENLVCKIADFG 416 Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708 +A +Y R G K + APE A +Y + ++DV+SFG+L +++T G Sbjct: 417 LARLIEDNEYTARQGAKF---PIKWTAPEAA----LYGRFTIKSDVWSFGILQTELVTKG 469 Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 G+ +++E ++P P GC + +L+ C K++P ERPT Sbjct: 470 RVPYPGMVNREVLEQVERGYRMPCP---QGCP--ESLHELMNLCWKKDPDERPT 518 >gi|1082750|pir||A49865 protein-tyrosine kinase (EC 2.7.1.112) matk, long splice form - human gi|459550|gb|AAA16703.1| tyrosine kinase Length = 527 Score = 73.9 bits (180), Expect = 3e-12 Identities = 55/183 (30%), Positives = 96/183 (52%), Gaps = 14/183 (7%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VME SKG+L L+ +L T Q + +LHVA+G+ YL S +++RDL N+L+ Sbjct: 302 IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 360 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 + ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+LL Sbjct: 361 ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHG--FTSKSDVWSFGVLL 413 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 +++ + G + + +E ++ P GC P P V L+ C + P Sbjct: 414 WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPPAGH 468 Query: 1762 TSA 1764 SA Sbjct: 469 PSA 471 >gi|2392699|pdb|2HCK|B Chain B, Src Family Kinase Hck-Quercetin Complex gi|2392698|pdb|2HCK|A Chain A, Src Family Kinase Hck-Quercetin Complex gi|2194104|pdb|1AD5|B Chain B, Src Family Kinase Hck-Amp-Pnp Complex gi|2194103|pdb|1AD5|A Chain A, Src Family Kinase Hck-Amp-Pnp Complex Length = 438 Score = 73.9 bits (180), Expect = 3e-12 Identities = 55/195 (28%), Positives = 99/195 (50%), Gaps = 23/195 (11%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 250 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 307 Query: 1637 NVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696 N+L+ +A+++ KIAD+G+A+ + IK + APE + ++DV+S Sbjct: 308 NILV-----SASLVCKIADFGLARVGAKFPIK-------WTAPEAINFGS-FTIKSDVWS 354 Query: 1697 FGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKEN 1756 FG+LL +I+T G G+ P LE ++P P C + ++ +C K Sbjct: 355 FGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMMRCWKNR 409 Query: 1757 PQERPTSAQVFDILN 1771 P+ERPT + +L+ Sbjct: 410 PEERPTFEYIQSVLD 424 >gi|7981277|emb|CAB91984.1| protein serine kinase [Homo sapiens] gi|38511462|gb|AAH62616.1| Protein serine kinase H1 [Homo sapiens] gi|27901803|ref|NP_006733.1| protein serine kinase H1 [Homo sapiens] gi|17379144|sp|P11801|KPSH1_HUMAN Serine/threonine-protein kinase H1 (PSK-H1) Length = 424 Score = 73.6 bits (179), Expect = 4e-12 Identities = 66/192 (34%), Positives = 98/192 (51%), Gaps = 22/192 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VMELA+ G L DR++ K S T R+ V DG+RYLH+ I +RDLKP N+L + Sbjct: 170 MVMELATGGELFDRIIA--KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYY 227 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG----IKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697 ++ II I D+G+A + G +KT+ GTP + APEV Y D+++ Sbjct: 228 HPGTDSKII--ITDFGLAS-ARKKGDDCLMKTTCGTPEYIAPEVLVRKP-YTNSVDMWAL 283 Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK----QCL 1753 G++ Y IL +G E + ++ ++GK Y PWP V L K + L Sbjct: 284 GVIAY-ILLSGTMPFEDDNRTRLYRQI-LRGKY-----SYSGEPWPSVSNLAKDFIDRLL 336 Query: 1754 KENPQERPTSAQ 1765 +P R T+ Q Sbjct: 337 TVDPGARMTALQ 348 >gi|56204061|emb|CAI23531.1| MAP3K7 [Homo sapiens] gi|56203689|emb|CAI19609.1| MAP3K7 [Homo sapiens] gi|21735566|ref|NP_663306.1| mitogen-activated protein kinase kinase kinase 7 isoform D [Homo sapiens] gi|6746615|gb|AAF27652.1| TGF beta-activated kinase splice variant d [Homo sapiens] Length = 491 Score = 73.2 bits (178), Expect = 6e-12 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630 A + P LVME A GSL +L + T H ++ L + G+ YLHS +I+ Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RDLKP N+LL + KI D+G A C + + ++G+ + APEV G+ Y+ Sbjct: 155 RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739 ++ DV+S+G++L++++T FDE+ G P +K Sbjct: 208 EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254 Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770 P P +E L+ +C ++P +RP+ ++ I+ Sbjct: 255 LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284 >gi|56204060|emb|CAI23530.1| MAP3K7 [Homo sapiens] gi|56203690|emb|CAI19610.1| MAP3K7 [Homo sapiens] gi|21735564|ref|NP_663305.1| mitogen-activated protein kinase kinase kinase 7 isoform C [Homo sapiens] gi|8978252|dbj|BAA25027.2| TGF-beta activated kinase 1c [Homo sapiens] Length = 518 Score = 73.2 bits (178), Expect = 6e-12 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630 A + P LVME A GSL +L + T H ++ L + G+ YLHS +I+ Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RDLKP N+LL + KI D+G A C + + ++G+ + APEV G+ Y+ Sbjct: 155 RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739 ++ DV+S+G++L++++T FDE+ G P +K Sbjct: 208 EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254 Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770 P P +E L+ +C ++P +RP+ ++ I+ Sbjct: 255 LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284 >gi|56204062|emb|CAI23532.1| MAP3K7 [Homo sapiens] gi|56203692|emb|CAI19612.1| MAP3K7 [Homo sapiens] gi|21735562|ref|NP_663304.1| mitogen-activated protein kinase kinase kinase 7 isoform B [Homo sapiens] gi|7513396|pir||JC5956 transforming growth factor-beta activated kinase (EC 2.7.-.-) 1b - human gi|12643557|sp|O43318|M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) gi|2924626|dbj|BAA25026.1| TGF-beta activated kinase 1b [Homo sapiens] Length = 606 Score = 73.2 bits (178), Expect = 6e-12 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630 A + P LVME A GSL +L + T H ++ L + G+ YLHS +I+ Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RDLKP N+LL + KI D+G A C + + ++G+ + APEV G+ Y+ Sbjct: 155 RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739 ++ DV+S+G++L++++T FDE+ G P +K Sbjct: 208 EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254 Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770 P P +E L+ +C ++P +RP+ ++ I+ Sbjct: 255 LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284 >gi|56204063|emb|CAI23533.1| MAP3K7 [Homo sapiens] gi|56203691|emb|CAI19611.1| MAP3K7 [Homo sapiens] gi|4507361|ref|NP_003179.1| mitogen-activated protein kinase kinase kinase 7 isoform A [Homo sapiens] gi|17389343|gb|AAH17715.1| Mitogen-activated protein kinase kinase kinase 7, isoform A [Homo sapiens] gi|7513395|pir||JC5955 transforming growth factor-beta activated kinase (EC 2.7.-.-) 1a - human gi|2924624|dbj|BAA25025.1| TGF-beta activated kinase 1a [Homo sapiens] Length = 579 Score = 73.2 bits (178), Expect = 6e-12 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630 A + P LVME A GSL +L + T H ++ L + G+ YLHS +I+ Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RDLKP N+LL + KI D+G A C + + ++G+ + APEV G+ Y+ Sbjct: 155 RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739 ++ DV+S+G++L++++T FDE+ G P +K Sbjct: 208 EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254 Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770 P P +E L+ +C ++P +RP+ ++ I+ Sbjct: 255 LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284 >gi|54696176|gb|AAV38460.1| mitogen-activated protein kinase kinase kinase 7 [Homo sapiens] Length = 579 Score = 73.2 bits (178), Expect = 6e-12 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630 A + P LVME A GSL +L + T H ++ L + G+ YLHS +I+ Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RDLKP N+LL + KI D+G A C + + ++G+ + APEV G+ Y+ Sbjct: 155 RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739 ++ DV+S+G++L++++T FDE+ G P +K Sbjct: 208 EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254 Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770 P P +E L+ +C ++P +RP+ ++ I+ Sbjct: 255 LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284 >gi|4507277|ref|NP_003148.1| NIMA (never in mitosis gene a)-related kinase 4 [Homo sapiens] gi|7427997|pir||I78885 serine/threonine-specific protein kinase (EC 2.7.1.-) STK2 - human gi|1709347|sp|P51957|NEK4_HUMAN Serine/threonine-protein kinase Nek4 (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) gi|348245|gb|AAA36658.1| protein serine/threonine kinase Length = 841 Score = 73.2 bits (178), Expect = 6e-12 Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 17/184 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VM G L R L++ K L Q + +A L+YLH I++RDLK NV L Sbjct: 81 IVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFL- 139 Query: 1642 TLYPNAAIIAKIADYGIAQYC---CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFG 1698 I K+ D GIA+ C M T GTP + +PE+ N YN ++DV++ G Sbjct: 140 ----TRTNIIKVGDLGIARVLENHCDMA-STLIGTPYYMSPELF-SNKPYNYKSDVWALG 193 Query: 1699 LLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 +Y++ T + K N I+GKLP ++Y P + +LI+ L + P+ Sbjct: 194 CCVYEMATL--KHAFNAKDMNSLVYRIIEGKLPAMPRDYS----PELAELIRTMLSKRPE 247 Query: 1759 ERPT 1762 ERP+ Sbjct: 248 ERPS 251 >gi|7513397|pir||JC5957 transforming growth factor-beta activated kinase (EC 2.7.-.-) 1c - human Length = 567 Score = 73.2 bits (178), Expect = 6e-12 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630 A + P LVME A GSL +L + T H ++ L + G+ YLHS +I+ Sbjct: 95 ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RDLKP N+LL + KI D+G A C + + ++G+ + APEV G+ Y+ Sbjct: 155 RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207 Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739 ++ DV+S+G++L++++T FDE+ G P +K Sbjct: 208 EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254 Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770 P P +E L+ +C ++P +RP+ ++ I+ Sbjct: 255 LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284 >gi|38648684|gb|AAH63044.1| NEK4 protein [Homo sapiens] Length = 781 Score = 73.2 bits (178), Expect = 6e-12 Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 17/184 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VM G L R L++ K L Q + +A L+YLH I++RDLK NV L Sbjct: 81 IVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFL- 139 Query: 1642 TLYPNAAIIAKIADYGIAQYC---CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFG 1698 I K+ D GIA+ C M T GTP + +PE+ N YN ++DV++ G Sbjct: 140 ----TRTNIIKVGDLGIARVLENHCDMA-STLIGTPYYMSPELF-SNKPYNYKSDVWALG 193 Query: 1699 LLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 +Y++ T + K N I+GKLP ++Y P + +LI+ L + P+ Sbjct: 194 CCVYEMATL--KHAFNAKDMNSLVYRIIEGKLPAMPRDYS----PELAELIRTMLSKRPE 247 Query: 1759 ERPT 1762 ERP+ Sbjct: 248 ERPS 251 >gi|56462535|emb|CAI16055.1| TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) [Homo sapiens] Length = 1124 Score = 72.8 bits (177), Expect = 7e-12 Identities = 64/205 (31%), Positives = 102/205 (49%), Gaps = 27/205 (13%) Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627 L +E A G+L R+L+ D A S TL + LH VA G+ YL Sbjct: 900 LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 959 Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686 I+RDL N+L+ Y +AKIAD+G+++ + +K + G R + N Sbjct: 960 FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 1013 Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746 +Y +DV+S+G+LL++I++ GG G+ +++L +L P+ C V Sbjct: 1014 VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 1068 Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771 L++QC +E P ERP+ AQ+ LN Sbjct: 1069 DLMRQCWREKPYERPSFAQILVSLN 1093 >gi|4557869|ref|NP_000450.1| TEK tyrosine kinase, endothelial [Homo sapiens] gi|2136092|pir||I58388 protein-tyrosine kinase (EC 2.7.1.112), receptor type tek precursor - human gi|464868|sp|Q02763|TIE2_HUMAN Angiopoietin 1 receptor precursor (Tyrosine-protein kinase receptor TIE-2) (Tyrosine-protein kinase receptor TEK) (P140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) gi|292824|gb|AAA61139.1| receptor protein-tyrosine kinase Length = 1124 Score = 72.8 bits (177), Expect = 7e-12 Identities = 64/205 (31%), Positives = 102/205 (49%), Gaps = 27/205 (13%) Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627 L +E A G+L R+L+ D A S TL + LH VA G+ YL Sbjct: 900 LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 959 Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686 I+RDL N+L+ Y +AKIAD+G+++ + +K + G R + N Sbjct: 960 FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 1013 Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746 +Y +DV+S+G+LL++I++ GG G+ +++L +L P+ C V Sbjct: 1014 VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 1068 Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771 L++QC +E P ERP+ AQ+ LN Sbjct: 1069 DLMRQCWREKPYERPSFAQILVSLN 1093 >gi|15988251|pdb|1FVR|B Chain B, Tie2 Kinase Domain gi|15988250|pdb|1FVR|A Chain A, Tie2 Kinase Domain Length = 327 Score = 72.8 bits (177), Expect = 7e-12 Identities = 64/205 (31%), Positives = 102/205 (49%), Gaps = 27/205 (13%) Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627 L +E A G+L R+L+ D A S TL + LH VA G+ YL Sbjct: 103 LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 162 Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686 I+RDL N+L+ Y +AKIAD+G+++ + +K + G R + N Sbjct: 163 FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 216 Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746 +Y +DV+S+G+LL++I++ GG G+ +++L +L P+ C V Sbjct: 217 VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 271 Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771 L++QC +E P ERP+ AQ+ LN Sbjct: 272 DLMRQCWREKPYERPSFAQILVSLN 296 >gi|47524177|ref|NP_075252.2| fibroblast growth factor receptor 4 isoform 2 precursor [Homo sapiens] Length = 762 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + L+ + A VA G++YL Sbjct: 505 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 564 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KTS G + APE Sbjct: 565 SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L ++ P C Sbjct: 620 -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 675 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775 P + L+++C P +RPT Q+ + L+ L Sbjct: 676 --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 708 >gi|21595367|gb|AAH32413.1| B lymphoid tyrosine kinase [Homo sapiens] gi|33469982|ref|NP_001706.2| B lymphoid tyrosine kinase [Homo sapiens] gi|13938455|gb|AAH07371.1| B lymphoid tyrosine kinase [Homo sapiens] Length = 505 Score = 72.4 bits (176), Expect = 1e-11 Identities = 60/201 (29%), Positives = 99/201 (49%), Gaps = 27/201 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P +V E ++G L L+ D+ S L R + ++ +A+G+ Y+ I+RDL+ Sbjct: 307 PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID--MSAQIAEGMAYIERMNSIHRDLRAA 364 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA-----QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691 N+L+ + A+ KIAD+G+A +Y + G K + APE V + + Sbjct: 365 NILV-----SEALCCKIADFGLARIIDSEYTAQEGAKFPIK---WTAPEAIHFGV-FTIK 415 Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751 ADV+SFG+LL +++T G G+ P LE ++P P P + +I + Sbjct: 416 ADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRP----DTCPPELYRGVIAE 471 Query: 1752 CLKENPQERPTSAQVFDILNS 1772 C + P+ERPT F+ L S Sbjct: 472 CWRSRPEERPT----FEFLQS 488 >gi|15080148|gb|AAH11847.1| Fibroblast growth factor receptor 4, isoform 1 precursor [Homo sapiens] gi|47524175|ref|NP_998812.1| fibroblast growth factor receptor 4 isoform 1 precursor [Homo sapiens] gi|47524173|ref|NP_002002.3| fibroblast growth factor receptor 4 isoform 1 precursor [Homo sapiens] gi|182571|gb|AAB59389.1| fibroblast growth factor receptor 4 gi|298629|gb|AAB25788.1| fibroblast growth factor receptor 4, FGFR4=transmembrane tyrosine kinase receptor [human, mammary epithelial cell line B5/589, Peptide, 802 aa] gi|13432140|sp|P22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 precursor (FGFR-4) Length = 802 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + L+ + A VA G++YL Sbjct: 545 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KTS G + APE Sbjct: 605 SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L ++ P C Sbjct: 660 -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775 P + L+++C P +RPT Q+ + L+ L Sbjct: 716 --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748 >gi|476558|pir||TVHUF4 fibroblast growth factor receptor 4 precursor - human gi|31372|emb|CAA40490.1| fibroblast growth factor receptor [Homo sapiens] Length = 802 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + L+ + A VA G++YL Sbjct: 545 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KTS G + APE Sbjct: 605 SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L ++ P C Sbjct: 660 -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775 P + L+++C P +RPT Q+ + L+ L Sbjct: 716 --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748 >gi|23273968|gb|AAH35514.1| TEK protein [Homo sapiens] Length = 1101 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/205 (31%), Positives = 101/205 (49%), Gaps = 27/205 (13%) Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627 L +E A G+L R+L+ D A S TL LH VA G+ YL Sbjct: 877 LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSHHLLHFAADVARGMDYLSQKQ 936 Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686 I+RDL N+L+ Y +AKIAD+G+++ + +K + G R + N Sbjct: 937 FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 990 Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746 +Y +DV+S+G+LL++I++ GG G+ +++L +L P+ C V Sbjct: 991 VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 1045 Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771 L++QC +E P ERP+ AQ+ LN Sbjct: 1046 DLMRQCWREKPYERPSFAQILVSLN 1070 >gi|20153207|gb|AAM13666.1| fibroblast growth factor receptor 4 [Homo sapiens] Length = 802 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + L+ + A VA G++YL Sbjct: 545 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KTS G + APE Sbjct: 605 SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L ++ P C Sbjct: 660 -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775 P + L+++C P +RPT Q+ + L+ L Sbjct: 716 --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748 >gi|18250298|ref|NP_543013.1| src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Homo sapiens] gi|27805732|sp|Q9H3Y6|SRMS_HUMAN Tyrosine-protein kinase Srms gi|11137518|emb|CAC15526.1| dJ697K14.1 (novel tyrosine kinase) [Homo sapiens] Length = 488 Score = 72.4 bits (176), Expect = 1e-11 Identities = 58/201 (28%), Positives = 100/201 (49%), Gaps = 15/201 (7%) Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHR-IALHVADGLRYLHSAMIIYRDLK 1634 +G P +V EL KG+L L + R A VA+G+ YL +++RDL Sbjct: 293 SGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLA 352 Query: 1635 PHNVLLFTLYPNAAIIAKIADYGIAQYC---CRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691 NVL+ + + K+AD+G+A+ +S+ + APE A V ++Q+ Sbjct: 353 ARNVLV-----DDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV-FSQK 406 Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751 +DV+SFG+LL+++ T G EG+ ++ +LP P A V L+ + Sbjct: 407 SDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRP-----AACPAEVYVLMLE 461 Query: 1752 CLKENPQERPTSAQVFDILNS 1772 C + +P+ERP+ A + + L++ Sbjct: 462 CWRSSPEERPSFATLREKLHA 482 >gi|13991618|gb|AAK51435.1| fibroblast growth factor receptor 4 variant [Homo sapiens] Length = 592 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + L+ + A VA G++YL Sbjct: 335 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 394 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KTS G + APE Sbjct: 395 SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 449 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L ++ P C Sbjct: 450 -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 505 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775 P + L+++C P +RPT Q+ + L+ L Sbjct: 506 --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 538 >gi|6739818|gb|AAF27432.1| fibroblast growth factor receptor 4, soluble-form splice variant [Homo sapiens] Length = 762 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + L+ + A VA G++YL Sbjct: 505 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 564 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KTS G + APE Sbjct: 565 SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L ++ P C Sbjct: 620 -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 675 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775 P + L+++C P +RPT Q+ + L+ L Sbjct: 676 --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 708 >gi|2117797|pir||I37206 protein-tyrosine kinase (EC 2.7.1.112) blk - human gi|601952|emb|CAA83965.1| Protein-Tyrosine Kinase [Homo sapiens] gi|1705485|sp|P51451|BLK_HUMAN Tyrosine-protein kinase BLK (B lymphocyte kinase) (p55-BLK) Length = 505 Score = 72.4 bits (176), Expect = 1e-11 Identities = 60/201 (29%), Positives = 99/201 (49%), Gaps = 27/201 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P +V E ++G L L+ D+ S L R + ++ +A+G+ Y+ I+RDL+ Sbjct: 307 PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID--MSAQIAEGMAYIERMNSIHRDLRAA 364 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA-----QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691 N+L+ + A+ KIAD+G+A +Y + G K + APE V + + Sbjct: 365 NILV-----SEALCCKIADFGLARIIDSEYTAQEGAKFPIK---WTAPEAIHFGV-FTIK 415 Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751 ADV+SFG+LL +++T G G+ P LE ++P P P + +I + Sbjct: 416 ADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRP----DTCPPELYRGVIAE 471 Query: 1752 CLKENPQERPTSAQVFDILNS 1772 C + P+ERPT F+ L S Sbjct: 472 CWRSRPEERPT----FEFLQS 488 >gi|2832350|emb|CAA74200.1| fibroblast growth factor 4 [Homo sapiens] Length = 802 Score = 72.4 bits (176), Expect = 1e-11 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + L+ + A VA G++YL Sbjct: 545 PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KTS G + APE Sbjct: 605 SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L ++ P C Sbjct: 660 -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775 P + L+++C P +RPT Q+ + L+ L Sbjct: 716 --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748 >gi|21735550|ref|NP_002437.2| mitogen-activated protein kinase kinase kinase 10 [Homo sapiens] Length = 954 Score = 72.0 bits (175), Expect = 1e-11 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 30/206 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRI---ALHVADGLRYLHS---AMIIYRDLKPH 1636 LVME A G+L R+L R H + A+ VA G+ YLH+ II+RDLK Sbjct: 172 LVMEYARGGALSRVLAG-----RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226 Query: 1637 NVLLFTLYPN---AAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 1693 N+L+ N A + KI D+G+A+ + ++ GT + APEV R + ++++ +D Sbjct: 227 NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS-LFSKSSD 285 Query: 1694 VYSFGLLLYDILTTGGRIVEGLKFPNEFDELEI-----QGKLPDPVKEYGCAPWPMVEKL 1748 V+SFG+LL+++LT G E D L + KL P+ P P +L Sbjct: 286 VWSFGVLLWELLT-------GEVPYREIDALAVAYGVAMNKLTLPIP--STCPEPFA-RL 335 Query: 1749 IKQCLKENPQERPTSAQVFDILNSAE 1774 +++C +P RP + L E Sbjct: 336 LEECWDPDPHGRPDFGSILKRLEVIE 361 >gi|971420|emb|CAA62351.1| mixed lineage kinase 2 [Homo sapiens] gi|2135747|pir||S68178 mixed-lineage protein kinase 2 (EC 2.7.1.-) - human gi|6686295|sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 72.0 bits (175), Expect = 1e-11 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 30/206 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRI---ALHVADGLRYLHS---AMIIYRDLKPH 1636 LVME A G+L R+L R H + A+ VA G+ YLH+ II+RDLK Sbjct: 172 LVMEYARGGALSRVLAG-----RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226 Query: 1637 NVLLFTLYPN---AAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 1693 N+L+ N A + KI D+G+A+ + ++ GT + APEV R + ++++ +D Sbjct: 227 NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS-LFSKSSD 285 Query: 1694 VYSFGLLLYDILTTGGRIVEGLKFPNEFDELEI-----QGKLPDPVKEYGCAPWPMVEKL 1748 V+SFG+LL+++LT G E D L + KL P+ P P +L Sbjct: 286 VWSFGVLLWELLT-------GEVPYREIDALAVAYGVAMNKLTLPIP--STCPEPFA-RL 335 Query: 1749 IKQCLKENPQERPTSAQVFDILNSAE 1774 +++C +P RP + L E Sbjct: 336 LEECWDPDPHGRPDFGSILKRLEVIE 361 >gi|758593|emb|CAA88531.1| serine/threonine kinase with SH3 domain, leucine zipper domain and proline rich domain [Homo sapiens] Length = 953 Score = 72.0 bits (175), Expect = 1e-11 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 30/206 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRI---ALHVADGLRYLHS---AMIIYRDLKPH 1636 LVME A G+L R+L R H + A+ VA G+ YLH+ II+RDLK Sbjct: 172 LVMEYARGGALSRVLAG-----RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226 Query: 1637 NVLLFTLYPN---AAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 1693 N+L+ N A + KI D+G+A+ + ++ GT + APEV R + ++++ +D Sbjct: 227 NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS-LFSKSSD 285 Query: 1694 VYSFGLLLYDILTTGGRIVEGLKFPNEFDELEI-----QGKLPDPVKEYGCAPWPMVEKL 1748 V+SFG+LL+++LT G E D L + KL P+ P P +L Sbjct: 286 VWSFGVLLWELLT-------GEVPYREIDALAVAYGVAMNKLTLPIP--STCPEPFA-RL 335 Query: 1749 IKQCLKENPQERPTSAQVFDILNSAE 1774 +++C +P RP + L E Sbjct: 336 LEECWDPDPHGRPDFGSILKRLEVIE 361 >gi|914204|gb|AAB33265.1| protein tyrosine kinase [Homo sapiens] Length = 505 Score = 72.0 bits (175), Expect = 1e-11 Identities = 60/201 (29%), Positives = 99/201 (49%), Gaps = 27/201 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P +V E ++G L L+ D+ S L R + ++ +A+G+ Y+ I+RDL+ Sbjct: 307 PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID--MSAQIAEGMAYIERMNSIHRDLRAA 364 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA-----QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691 N+L+ + A+ KIAD+G+A +Y + G K + APE V + + Sbjct: 365 NILV-----SEALCCKIADFGLARIIDSEYTAQEGAKFPIK---WTAPEAYHFGV-FTIK 415 Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751 ADV+SFG+LL +++T G G+ P LE ++P P P + +I + Sbjct: 416 ADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRP----DTCPPELYRGVIAE 471 Query: 1752 CLKENPQERPTSAQVFDILNS 1772 C + P+ERPT F+ L S Sbjct: 472 CWRSRPEERPT----FEFLQS 488 >gi|56203175|emb|CAI22966.1| HCK [Homo sapiens] gi|56205100|emb|CAI19694.1| HCK [Homo sapiens] gi|15680177|gb|AAH14435.1| Unknown (protein for MGC:22922) [Homo sapiens] gi|2144421|pir||TVHUHC protein-tyrosine kinase (EC 2.7.1.112) hck - human gi|306833|gb|AAA52644.1| protein-tyrosine kinase Length = 505 Score = 71.6 bits (174), Expect = 2e-11 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 307 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 364 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 N+L+ +A+++ KIAD+G+A +Y R G K + APE + Sbjct: 365 NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 415 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LL +I+T G G+ P LE ++P P C + ++ Sbjct: 416 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 470 Query: 1751 QCLKENPQERPTSAQVFDILN 1771 +C K P+ERPT + +L+ Sbjct: 471 RCWKNRPEERPTFEYIQSVLD 491 >gi|306832|gb|AAA52643.1| protein-tyrosine kinase Length = 505 Score = 71.6 bits (174), Expect = 2e-11 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 307 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 364 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 N+L+ +A+++ KIAD+G+A +Y R G K + APE + Sbjct: 365 NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 415 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LL +I+T G G+ P LE ++P P C + ++ Sbjct: 416 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 470 Query: 1751 QCLKENPQERPTSAQVFDILN 1771 +C K P+ERPT + +L+ Sbjct: 471 RCWKNRPEERPTFEYIQSVLD 491 >gi|30795229|ref|NP_002101.2| hemopoietic cell kinase isoform p61HCK [Homo sapiens] gi|20141296|sp|P08631|HCK_HUMAN Tyrosine-protein kinase HCK (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 526 Score = 71.6 bits (174), Expect = 2e-11 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 328 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 385 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 N+L+ +A+++ KIAD+G+A +Y R G K + APE + Sbjct: 386 NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 436 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LL +I+T G G+ P LE ++P P C + ++ Sbjct: 437 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 491 Query: 1751 QCLKENPQERPTSAQVFDILN 1771 +C K P+ERPT + +L+ Sbjct: 492 RCWKNRPEERPTFEYIQSVLD 512 >gi|56203176|emb|CAI22967.1| HCK [Homo sapiens] gi|56205101|emb|CAI19695.1| HCK [Homo sapiens] Length = 504 Score = 71.6 bits (174), Expect = 2e-11 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 306 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 363 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 N+L+ +A+++ KIAD+G+A +Y R G K + APE + Sbjct: 364 NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 414 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LL +I+T G G+ P LE ++P P C + ++ Sbjct: 415 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 469 Query: 1751 QCLKENPQERPTSAQVFDILN 1771 +C K P+ERPT + +L+ Sbjct: 470 RCWKNRPEERPTFEYIQSVLD 490 >gi|10439296|dbj|BAB15482.1| unnamed protein product [Homo sapiens] Length = 505 Score = 71.6 bits (174), Expect = 2e-11 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 307 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 364 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 N+L+ +A+++ KIAD+G+A +Y R G K + APE + Sbjct: 365 NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 415 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LL +I+T G G+ P LE ++P P C + ++ Sbjct: 416 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 470 Query: 1751 QCLKENPQERPTSAQVFDILN 1771 +C K P+ERPT + +L+ Sbjct: 471 RCWKNRPEERPTFEYIQSVLD 491 >gi|19923729|ref|NP_115646.2| hypothetical protein AD158 [Homo sapiens] gi|19570360|dbj|BAB86303.1| AD158 [Homo sapiens] Length = 803 Score = 71.6 bits (174), Expect = 2e-11 Identities = 78/302 (25%), Positives = 140/302 (46%), Gaps = 33/302 (10%) Query: 741 LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS---RNDIGPSV 797 L +CS + + S ++L L + + P ++ + + L + +DI +V Sbjct: 474 LHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNV 533 Query: 798 VLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKIL 857 L+ +LK ++ N +S +P+ + DV L+++ + + K + + Sbjct: 534 TLESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGT---------KLVMLN 583 Query: 858 NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 NL K +++L+E L C A + L S+ L L +N I E I++ Sbjct: 584 NLKK--MTNLTELELVHCDLERIPHAVFSLL--------SLQELDLKENNLKSIEE-IVS 632 Query: 918 LPHLRSLDMSS---NDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVEKL 973 HLR L + N I Y+P H K L +L L FSHN+I +L +L +++ L Sbjct: 633 FQHLRKLTVLKLWHNSITYIP--EHIKKLTSLERLSFSHNKIEVLP--SHLFLCNKIRYL 688 Query: 974 HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKH 1033 LS+N ++ IPPEIG L++L ++ N ++ S P+E+ K+ L + + L+ Sbjct: 689 DLSYNDIRFIPPEIGVLQSLQYFSITCN-KVESLPDELYFCKKLKTLKIGKNSLSVLSPK 747 Query: 1034 IG 1035 IG Sbjct: 748 IG 749 Score = 61.6 bits (148), Expect = 2e-08 Identities = 72/271 (26%), Positives = 117/271 (43%), Gaps = 38/271 (14%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS--------RNDIGPSVVLDPTV 803 S ++TL+SL DL S K S S + K+ A +DVS ND V+L+ Sbjct: 530 SRNVTLESLR--DLKSLKILSIKSNVSKIPQ-AVVDVSSHLQKMCIHNDGTKLVMLNNLK 586 Query: 804 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSK 861 K L + L + L +P + ++ E + E N I I S L++L +L L Sbjct: 587 KMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWH 646 Query: 862 NHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHL 921 N I+ + E+ + S+ L S NK +P + + Sbjct: 647 NSITYIPEHIKKLT---------------------SLERLSFSHNKIEVLPSHLFLCNKI 685 Query: 922 RSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981 R LD+S NDI+++P P +L+ + N++ L ++ Y +++ L + N L Sbjct: 686 RYLDLSYNDIRFIP-PEIGVLQSLQYFSITCNKVE--SLPDELYFCKKLKTLKIGKNSLS 742 Query: 982 EIPPEIGCLENLTSLDVSYNLELRSFPNEMG 1012 + P+IG L L+ LDV N P E+G Sbjct: 743 VLSPKIGNLLFLSYLDVKGN-HFEILPPELG 772 >gi|50949358|emb|CAB66853.2| hypothetical protein [Homo sapiens] Length = 716 Score = 71.6 bits (174), Expect = 2e-11 Identities = 78/302 (25%), Positives = 140/302 (46%), Gaps = 33/302 (10%) Query: 741 LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS---RNDIGPSV 797 L +CS + + S ++L L + + P ++ + + L + +DI +V Sbjct: 387 LHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNV 446 Query: 798 VLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKIL 857 L+ +LK ++ N +S +P+ + DV L+++ + + K + + Sbjct: 447 TLESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGT---------KLVMLN 496 Query: 858 NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 NL K +++L+E L C A + L S+ L L +N I E I++ Sbjct: 497 NLKK--MTNLTELELVHCDLERIPHAVFSLL--------SLQELDLKENNLKSIEE-IVS 545 Query: 918 LPHLRSLDMSS---NDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVEKL 973 HLR L + N I Y+P H K L +L L FSHN+I +L +L +++ L Sbjct: 546 FQHLRKLTVLKLWHNSITYIP--EHIKKLTSLERLSFSHNKIEVLP--SHLFLCNKIRYL 601 Query: 974 HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKH 1033 LS+N ++ IPPEIG L++L ++ N ++ S P+E+ K+ L + + L+ Sbjct: 602 DLSYNDIRFIPPEIGVLQSLQYFSITCN-KVESLPDELYFCKKLKTLKIGKNSLSVLSPK 660 Query: 1034 IG 1035 IG Sbjct: 661 IG 662 Score = 61.6 bits (148), Expect = 2e-08 Identities = 72/271 (26%), Positives = 117/271 (43%), Gaps = 38/271 (14%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS--------RNDIGPSVVLDPTV 803 S ++TL+SL DL S K S S + K+ A +DVS ND V+L+ Sbjct: 443 SRNVTLESLR--DLKSLKILSIKSNVSKIPQ-AVVDVSSHLQKMCIHNDGTKLVMLNNLK 499 Query: 804 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSK 861 K L + L + L +P + ++ E + E N I I S L++L +L L Sbjct: 500 KMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWH 559 Query: 862 NHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHL 921 N I+ + E+ + S+ L S NK +P + + Sbjct: 560 NSITYIPEHIKKLT---------------------SLERLSFSHNKIEVLPSHLFLCNKI 598 Query: 922 RSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981 R LD+S NDI+++P P +L+ + N++ L ++ Y +++ L + N L Sbjct: 599 RYLDLSYNDIRFIP-PEIGVLQSLQYFSITCNKVE--SLPDELYFCKKLKTLKIGKNSLS 655 Query: 982 EIPPEIGCLENLTSLDVSYNLELRSFPNEMG 1012 + P+IG L L+ LDV N P E+G Sbjct: 656 VLSPKIGNLLFLSYLDVKGN-HFEILPPELG 685 >gi|5542349|pdb|1QCF|A Chain A, Crystal Structure Of Hck In Complex With A Src Family- Selective Tyrosine Kinase Inhibitor Length = 454 Score = 71.6 bits (174), Expect = 2e-11 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 256 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 313 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 N+L+ +A+++ KIAD+G+A +Y R G K + APE + Sbjct: 314 NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 364 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LL +I+T G G+ P LE ++P P C + ++ Sbjct: 365 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 419 Query: 1751 QCLKENPQERPTSAQVFDILN 1771 +C K P+ERPT + +L+ Sbjct: 420 RCWKNRPEERPTFEYIQSVLD 440 >gi|5804911|emb|CAA41565.2| tyrosine kinase [Homo sapiens] Length = 348 Score = 71.6 bits (174), Expect = 2e-11 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%) Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D+ S L + + + +A+G+ ++ I+RDL+ Sbjct: 150 PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 207 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 N+L+ +A+++ KIAD+G+A +Y R G K + APE + Sbjct: 208 NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 258 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LL +I+T G G+ P LE ++P P C + ++ Sbjct: 259 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 313 Query: 1751 QCLKENPQERPTSAQVFDILN 1771 +C K P+ERPT + +L+ Sbjct: 314 RCWKNRPEERPTFEYIQSVLD 334 >gi|56204189|emb|CAI23046.1| mixed lineage kinase 4 (KIAA1804) [Homo sapiens] Length = 1036 Score = 70.9 bits (172), Expect = 3e-11 Identities = 62/218 (28%), Positives = 109/218 (50%), Gaps = 29/218 (13%) Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627 LV+E A G+L+R L A+ R H + A+ +A G+ YLH Sbjct: 198 LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257 Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683 I++RDLK N+LL + I KI D+G+A+ R ++ GT + APEV + Sbjct: 258 PILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317 Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + ++++ +D++S+G+LL+++LT R ++GL ++ +P P Sbjct: 318 SS-LFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 P KL+K+C +++P RP+ A + + L + E +T Sbjct: 371 EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407 >gi|4503743|ref|NP_002009.1| flightless I homolog [Homo sapiens] gi|19263700|gb|AAH25300.1| Flightless I homolog [Homo sapiens] gi|2138290|gb|AAC02796.1| see GenBank Accession Number U01184 for cDNA; similar to Drosophila melanogaster fliI in GenBank Accession Number U01182 and Caenorhabditis elegans fliI homolog in GenBank Accession Number U01183 [Homo sapiens] gi|18202493|sp|Q13045|FLII_HUMAN Flightless-I protein homolog Length = 1269 Score = 70.9 bits (172), Expect = 3e-11 Identities = 86/307 (28%), Positives = 131/307 (42%), Gaps = 45/307 (14%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L+ L HL + N T+ L + + + N + S V D K L +LS+N Sbjct: 55 LQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHN 114 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL--RLKELKILNLSKNHISSLSENF--- 871 QL+ P L + L L L N I I + L L +L L+LS+N + SL Sbjct: 115 QLTECPRELENAKNMLV-LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRL 173 Query: 872 -------LEACPKVESFSARMNFLAAMPFL------------PPSMTILK------LSQN 906 L P + + ++ + A+ L P S+ L LS N Sbjct: 174 VHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 233 Query: 907 KFSCIPEAILNLPHLRSLDMSSNDIQYL----PGPAHWKSLNLRELLFSHNQISILDLSE 962 + +PE + LP LR L++SSN I L H ++LNL S NQ++ L Sbjct: 234 DLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL-----SRNQLT--SLPS 286 Query: 963 KAYLWSRVEKLHLSHNKL--KEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020 S+++KL+L+ NKL +P IG L NL ++ N L P + + K+ L Sbjct: 287 AICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF-MAANNNLELVPESLCRCPKLRKL 345 Query: 1021 PLDELHL 1027 L++ HL Sbjct: 346 VLNKNHL 352 Score = 51.6 bits (122), Expect = 2e-05 Identities = 55/198 (27%), Positives = 87/198 (43%), Gaps = 31/198 (15%) Query: 742 QRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLD 800 QR NL L+ +L +DL N T P L + + L++S N I S+ +D Sbjct: 209 QRTQSNLPTSLEGLS--NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 266 Query: 801 PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKIS--GICSPL-RLKELKIL 857 V TL NLS NQL+ +P + + KL++L L NK+ G+ S + +L L+ Sbjct: 267 QWVHVETL---NLSRNQLTSLPSAICKL-SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322 Query: 858 NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 + N++ + E+ CPK+ L L++N +PEAI Sbjct: 323 MAANNNLELVPESLCR-CPKLRK--------------------LVLNKNHLVTLPEAIHF 361 Query: 918 LPHLRSLDMSSNDIQYLP 935 L + LD+ N +P Sbjct: 362 LTEIEVLDVRENPNLVMP 379 Score = 45.4 bits (106), Expect = 0.001 Identities = 33/116 (28%), Positives = 60/116 (51%), Gaps = 4/116 (3%) Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQI 955 S+ LKL++ +PE + L L L +S N++ L G SL +LR ++ N + Sbjct: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGEL--SSLPSLRAIVARANSL 91 Query: 956 SILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEM 1011 + + + + L LSHN+L E P E+ +N+ L++S+N + + PN++ Sbjct: 92 KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHN-SIDTIPNQL 146 Score = 37.7 bits (86), Expect = 0.26 Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 4/117 (3%) Query: 913 EAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVE 971 EA LP +R +D+S ND + P + K++ +LR L N+ + L E+ ++E Sbjct: 2 EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKL--NRTGLCYLPEELAALQKLE 59 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYN-LELRSFPNEMGKLSKIWDLPLDELHL 1027 L +SHN L + E+ L +L ++ N L+ P+++ KL + L L L Sbjct: 60 HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQL 116 >gi|56204188|emb|CAI23045.1| mixed lineage kinase 4 (KIAA1804) [Homo sapiens] Length = 570 Score = 70.9 bits (172), Expect = 3e-11 Identities = 62/218 (28%), Positives = 109/218 (50%), Gaps = 29/218 (13%) Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627 LV+E A G+L+R L A+ R H + A+ +A G+ YLH Sbjct: 198 LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257 Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683 I++RDLK N+LL + I KI D+G+A+ R ++ GT + APEV + Sbjct: 258 PILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317 Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + ++++ +D++S+G+LL+++LT R ++GL ++ +P P Sbjct: 318 SS-LFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 P KL+K+C +++P RP+ A + + L + E +T Sbjct: 371 EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407 >gi|2135121|pir||A49674 flightless-I homolog - human (fragment) gi|440177|gb|AAC03568.1| flightless-I homolog [Homo sapiens] Length = 1268 Score = 70.9 bits (172), Expect = 3e-11 Identities = 86/307 (28%), Positives = 131/307 (42%), Gaps = 45/307 (14%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L+ L HL + N T+ L + + + N + S V D K L +LS+N Sbjct: 54 LQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHN 113 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL--RLKELKILNLSKNHISSLSENF--- 871 QL+ P L + L L L N I I + L L +L L+LS+N + SL Sbjct: 114 QLTECPRELENAKNMLV-LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRL 172 Query: 872 -------LEACPKVESFSARMNFLAAMPFL------------PPSMTILK------LSQN 906 L P + + ++ + A+ L P S+ L LS N Sbjct: 173 VHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 232 Query: 907 KFSCIPEAILNLPHLRSLDMSSNDIQYL----PGPAHWKSLNLRELLFSHNQISILDLSE 962 + +PE + LP LR L++SSN I L H ++LNL S NQ++ L Sbjct: 233 DLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL-----SRNQLT--SLPS 285 Query: 963 KAYLWSRVEKLHLSHNKL--KEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020 S+++KL+L+ NKL +P IG L NL ++ N L P + + K+ L Sbjct: 286 AICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF-MAANNNLELVPESLCRCPKLRKL 344 Query: 1021 PLDELHL 1027 L++ HL Sbjct: 345 VLNKNHL 351 Score = 51.6 bits (122), Expect = 2e-05 Identities = 55/198 (27%), Positives = 87/198 (43%), Gaps = 31/198 (15%) Query: 742 QRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLD 800 QR NL L+ +L +DL N T P L + + L++S N I S+ +D Sbjct: 208 QRTQSNLPTSLEGLS--NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 265 Query: 801 PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKIS--GICSPL-RLKELKIL 857 V TL NLS NQL+ +P + + KL++L L NK+ G+ S + +L L+ Sbjct: 266 QWVHVETL---NLSRNQLTSLPSAICKL-SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 321 Query: 858 NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 + N++ + E+ CPK+ L L++N +PEAI Sbjct: 322 MAANNNLELVPESLCR-CPKLRK--------------------LVLNKNHLVTLPEAIHF 360 Query: 918 LPHLRSLDMSSNDIQYLP 935 L + LD+ N +P Sbjct: 361 LTEIEVLDVRENPNLVMP 378 Score = 45.4 bits (106), Expect = 0.001 Identities = 33/116 (28%), Positives = 60/116 (51%), Gaps = 4/116 (3%) Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQI 955 S+ LKL++ +PE + L L L +S N++ L G SL +LR ++ N + Sbjct: 33 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGEL--SSLPSLRAIVARANSL 90 Query: 956 SILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEM 1011 + + + + L LSHN+L E P E+ +N+ L++S+N + + PN++ Sbjct: 91 KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHN-SIDTIPNQL 145 Score = 37.7 bits (86), Expect = 0.26 Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 4/117 (3%) Query: 913 EAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVE 971 EA LP +R +D+S ND + P + K++ +LR L N+ + L E+ ++E Sbjct: 1 EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKL--NRTGLCYLPEELAALQKLE 58 Query: 972 KLHLSHNKLKEIPPEIGCLENLTSLDVSYN-LELRSFPNEMGKLSKIWDLPLDELHL 1027 L +SHN L + E+ L +L ++ N L+ P+++ KL + L L L Sbjct: 59 HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQL 115 >gi|5174647|ref|NP_005966.1| PTK6 protein tyrosine kinase 6 [Homo sapiens] gi|1082891|pir||S49016 protein-tyrosine kinase (EC 2.7.1.112) brk - human gi|3551753|gb|AAC34935.1| non-receptor type protein tyrosine kinase [Homo sapiens] gi|8928302|sp|Q13882|PTK6_HUMAN Tyrosine-protein kinase 6 (Breast tumor kinase) (Tyrosine-protein kinase brk) gi|11137517|emb|CAC15525.1| dJ697K14.2 (tyrosine kinase) [Homo sapiens] gi|515026|emb|CAA55295.1| tyrosine kinase [Homo sapiens] Length = 451 Score = 70.5 bits (171), Expect = 4e-11 Identities = 59/197 (29%), Positives = 104/197 (52%), Gaps = 16/197 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQ-DKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P ++ EL +KGSL LL+ D+ L + IA VA+G+ YL S I+RDL N+ Sbjct: 259 PVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNI 318 Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCR-MGIKTSEGTP-GFRAPE-VARGNVIYNQQADVY 1695 L+ + K+ D+G+A+ + + P + APE ++RG+ Y+ ++DV+ Sbjct: 319 LV-----GENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGH--YSTKSDVW 371 Query: 1696 SFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKE 1755 SFG+LL+++ + G G+ F ++ ++P P++ C P V KL+ C Sbjct: 372 SFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLE---CP--PSVHKLMLTCWCR 426 Query: 1756 NPQERPTSAQVFDILNS 1772 +P++RP + + L+S Sbjct: 427 DPEQRPCFKALRERLSS 443 >gi|37181696|gb|AAQ88655.1| SAPS287 [Homo sapiens] gi|40255157|ref|NP_700356.2| leucine-rich repeats and immunoglobulin-like domains 3 [Homo sapiens] gi|41020772|gb|AAR98629.1| leucine-rich and immunoglobulin-like domains 3 [Homo sapiens] Length = 1119 Score = 70.1 bits (170), Expect = 5e-11 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 45/274 (16%) Query: 763 LDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVP 822 LD + P L S +A LD+S N + + +L++ L+ N+L +P Sbjct: 58 LDCSRKRLARLPEPL--PSWVARLDLSHNRLS-FIKASSMSHLQSLREVKLNNNELETIP 114 Query: 823 ENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKNHISSLSENFLEACPKVE 879 NL V + L L GN+I I P LKE L+ L+LS N+IS L F +++ Sbjct: 115 -NLGPVSANITLLSLAGNRIVEIL-PEHLKEFQSLETLDLSSNNISELQTAF--PALQLK 170 Query: 880 SFSARMNFLAAMP-----FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934 N + +M L ++ +LKL++N+ S IP + LP L+ L+++ N I+ + Sbjct: 171 YLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNV 230 Query: 935 PG------------------------PAHWKSLNLRELLFSHNQISILDLSEKAYLWS-- 968 G A W N+ L HN ++ + K +L+ Sbjct: 231 DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI---TKGWLYGLL 287 Query: 969 RVEKLHLSHNKLKEIPPEI-GCLENLTSLDVSYN 1001 +++LHLS N + I P+ + L+ LD+++N Sbjct: 288 MLQELHLSQNAINRISPDAWEFCQKLSELDLTFN 321 Score = 52.4 bits (124), Expect = 1e-05 Identities = 67/286 (23%), Positives = 125/286 (43%), Gaps = 30/286 (10%) Query: 759 SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818 +L L L+ N+ ++ P + K+ + +L+++RN I +V LK + N + Sbjct: 193 TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKI-KNVDGLTFQGLGALKSLKMQRNGV 251 Query: 819 SFVPENLTDVVEKLEQLILEGNKISGICSP--LRLKELKILNLSKNHISSLSENFLEACP 876 + + + + +E L L+ N ++ I L L+ L+LS+N I+ +S + E C Sbjct: 252 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311 Query: 877 KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 K+ N L+ +L + F L L L +L + +N + Y+ Sbjct: 312 KLSELDLTFNHLS------------RLDDSSF-------LGLSLLNTLHIGNNRVSYIAD 352 Query: 937 PAHWKSLNLRELLFSHNQIS--ILDLSEKAYLWSRVEKLHLSHNKLKEIPPE-IGCLENL 993 A +L+ L +N+IS I D++ ++ +L L N+++ I + L+ L Sbjct: 353 CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 412 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAK 1039 LD+S N + N ++ K L +LHLN C+ K Sbjct: 413 EHLDLSDNAIMSLQGNAFSQMKK-----LQQLHLNTSSLLCDCQLK 453 Score = 33.5 bits (75), Expect = 4.9 Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 6/106 (5%) Query: 924 LDMSSNDIQYLPGPA-HWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKE 982 LD S + LP P W + L SHN++S + S ++L S + ++ L++N+L+ Sbjct: 58 LDCSRKRLARLPEPLPSW----VARLDLSHNRLSFIKASSMSHLQS-LREVKLNNNELET 112 Query: 983 IPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028 IP N+T L ++ N + P + + + L L +++ Sbjct: 113 IPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS 158 >gi|47458813|ref|NP_006242.4| protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 1 [Homo sapiens] gi|5410312|gb|AAD43027.1| AMP-activated kinase alpha 1 subunit [Homo sapiens] gi|27469582|gb|AAH37303.1| PRKAA1 protein [Homo sapiens] Length = 550 Score = 70.1 bits (170), Expect = 5e-11 Identities = 43/124 (34%), Positives = 69/124 (55%), Gaps = 7/124 (5%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME S G L + ++ L R+ + G+ Y H M+++RDLKP NVLL Sbjct: 93 MVMEYVSGGELFDYICKN-GRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL-- 149 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 +A + AKIAD+G++ ++TS G+P + APEV G + + D++S G++L Sbjct: 150 ---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVIL 206 Query: 1702 YDIL 1705 Y +L Sbjct: 207 YALL 210 >gi|20178277|sp|Q13131|AAPK1_HUMAN 5'-AMP-activated protein kinase, catalytic alpha-1 chain (AMPK alpha-1 chain) gi|4115829|dbj|BAA36547.1| AMP-activated protein kinase alpha-1 [Homo sapiens] Length = 550 Score = 70.1 bits (170), Expect = 5e-11 Identities = 43/124 (34%), Positives = 69/124 (55%), Gaps = 7/124 (5%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME S G L + ++ L R+ + G+ Y H M+++RDLKP NVLL Sbjct: 93 MVMEYVSGGELFDYICKN-GRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL-- 149 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 +A + AKIAD+G++ ++TS G+P + APEV G + + D++S G++L Sbjct: 150 ---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVIL 206 Query: 1702 YDIL 1705 Y +L Sbjct: 207 YALL 210 >gi|50845418|ref|NP_065973.2| WNK lysine deficient protein kinase 3 isoform 1 [Homo sapiens] gi|40738019|gb|AAR89465.1| putative protein kinase WNK3 [Homo sapiens] Length = 1800 Score = 69.7 bits (169), Expect = 6e-11 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%) Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624 + F + E +L G + +LV EL + G+L L++ K + L+ + GL++LH Sbjct: 207 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265 Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682 + II+RDLK N+ F P ++ KI D G+A K+ GTP F APE+ Sbjct: 266 TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321 Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740 + Y++ DVY+FG+ + ++ T+ + + +I K+ +K + Sbjct: 322 EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773 P V+++I+ C+++N ER + D+LN A Sbjct: 374 TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403 >gi|30016945|gb|AAP03432.1| v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens] gi|17390263|gb|AAH18119.1| V-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens] gi|4506401|ref|NP_002871.1| v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens] gi|66762|pir||TVHUF6 protein kinase raf-1 (EC 2.7.1.-) - human gi|125651|sp|P04049|RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (Raf-1) (C-RAF) (cRaf) gi|35842|emb|CAA27204.1| unnamed protein product [Homo sapiens] Length = 648 Score = 69.7 bits (169), Expect = 6e-11 Identities = 56/172 (32%), Positives = 92/172 (53%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RD+K +N+ L + + KI D+G+A R + Sbjct: 448 IARQTAQGMDYLHAKNIIHRDMKSNNIFL-----HEGLTVKIGDFGLATVKSRWSGSQQV 502 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R N ++ Q+DVYS+G++LY+++ TG + ++ + Sbjct: 503 EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM-TGELPYSHINNRDQIIFMV 561 Query: 1726 IQG-KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G PD K Y P M ++L+ C+K+ +ERP Q IL+S EL+ Sbjct: 562 GRGYASPDLSKLYKNCPKAM-KRLVADCVKKVKEERPLFPQ---ILSSIELL 609 >gi|4826878|ref|NP_005100.1| oxidative-stress responsive 1 [Homo sapiens] gi|14250548|gb|AAH08726.1| Oxidative-stress responsive 1 [Homo sapiens] gi|4519629|dbj|BAA75674.1| oxidative-stress responsive 1 [Homo sapiens] Length = 527 Score = 69.7 bits (169), Expect = 6e-11 Identities = 61/205 (29%), Positives = 98/205 (47%), Gaps = 30/205 (14%) Query: 1583 LVMELASKGSLDRLLQQDKAS-------LTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635 LVM+L S GS+ +++ A L + I V +GL YLH I+RD+K Sbjct: 90 LVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKA 149 Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688 N+LL +IAD+G++ + G KT GTP + APEV Y Sbjct: 150 GNILL-----GEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGY 204 Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + +AD++SFG+ ++ T V L N+ LE + + +K+YG Sbjct: 205 DFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYG--- 261 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766 K+I CL+++P++RPT+A++ Sbjct: 262 -KSFRKMISLCLQKDPEKRPTAAEL 285 >gi|57284054|emb|CAI43129.1| protein kinase, lysine deficient 3 [Homo sapiens] gi|57210008|emb|CAI42733.1| protein kinase, lysine deficient 3 [Homo sapiens] gi|57209550|emb|CAI40708.1| protein kinase, lysine deficient 3 [Homo sapiens] gi|50845416|ref|NP_001002838.1| WNK lysine deficient protein kinase 3 isoform 2 [Homo sapiens] gi|41688792|sp|Q9BYP7|WNK3_HUMAN Serine/threonine-protein kinase WNK3 (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3) gi|19032238|emb|CAC32455.2| protein kinase WNK3 [Homo sapiens] Length = 1743 Score = 69.7 bits (169), Expect = 6e-11 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%) Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624 + F + E +L G + +LV EL + G+L L++ K + L+ + GL++LH Sbjct: 207 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265 Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682 + II+RDLK N+ F P ++ KI D G+A K+ GTP F APE+ Sbjct: 266 TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321 Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740 + Y++ DVY+FG+ + ++ T+ + + +I K+ +K + Sbjct: 322 EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773 P V+++I+ C+++N ER + D+LN A Sbjct: 374 TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403 >gi|57284053|emb|CAI43128.1| protein kinase, lysine deficient 3 [Homo sapiens] gi|57210007|emb|CAI42732.1| protein kinase, lysine deficient 3 [Homo sapiens] gi|57209549|emb|CAI40707.1| protein kinase, lysine deficient 3 [Homo sapiens] Length = 1790 Score = 69.7 bits (169), Expect = 6e-11 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%) Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624 + F + E +L G + +LV EL + G+L L++ K + L+ + GL++LH Sbjct: 207 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265 Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682 + II+RDLK N+ F P ++ KI D G+A K+ GTP F APE+ Sbjct: 266 TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321 Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740 + Y++ DVY+FG+ + ++ T+ + + +I K+ +K + Sbjct: 322 EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773 P V+++I+ C+++N ER + D+LN A Sbjct: 374 TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403 >gi|40789046|dbj|BAA83053.2| KIAA1101 protein [Homo sapiens] Length = 467 Score = 69.7 bits (169), Expect = 6e-11 Identities = 61/205 (29%), Positives = 98/205 (47%), Gaps = 30/205 (14%) Query: 1583 LVMELASKGSLDRLLQQDKAS-------LTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635 LVM+L S GS+ +++ A L + I V +GL YLH I+RD+K Sbjct: 30 LVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKA 89 Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688 N+LL +IAD+G++ + G KT GTP + APEV Y Sbjct: 90 GNILL-----GEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGY 144 Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + +AD++SFG+ ++ T V L N+ LE + + +K+YG Sbjct: 145 DFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYG--- 201 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766 K+I CL+++P++RPT+A++ Sbjct: 202 -KSFRKMISLCLQKDPEKRPTAAEL 225 >gi|19908348|gb|AAL99253.1| putative protein kinase WNK3 [Homo sapiens] Length = 1800 Score = 69.7 bits (169), Expect = 6e-11 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%) Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624 + F + E +L G + +LV EL + G+L L++ K + L+ + GL++LH Sbjct: 207 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265 Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682 + II+RDLK N+ F P ++ KI D G+A K+ GTP F APE+ Sbjct: 266 TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321 Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740 + Y++ DVY+FG+ + ++ T+ + + +I K+ +K + Sbjct: 322 EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773 P V+++I+ C+++N ER + D+LN A Sbjct: 374 TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403 >gi|496091|gb|AAA60247.1| RAF1 Length = 421 Score = 69.7 bits (169), Expect = 6e-11 Identities = 56/172 (32%), Positives = 92/172 (53%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RD+K +N+ L + + KI D+G+A R + Sbjct: 221 IARQTAQGMDYLHAKNIIHRDMKSNNIFL-----HEGLTVKIGDFGLATVKSRWSGSQQV 275 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R N ++ Q+DVYS+G++LY+++ TG + ++ + Sbjct: 276 EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELI-TGELPYSHINNRDQIIFMV 334 Query: 1726 IQG-KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G PD K Y P M ++L+ C+K+ +ERP Q IL+S EL+ Sbjct: 335 GRGYASPDLSKLYKNCPKAM-KRLVADCVKKVKEERPLFPQ---ILSSIELL 382 >gi|227082|prf||1613537A c-raf1 protooncogene Length = 386 Score = 69.7 bits (169), Expect = 6e-11 Identities = 56/172 (32%), Positives = 92/172 (53%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RD+K +N+ L + + KI D+G+A R + Sbjct: 186 IARQTAQGMDYLHAKNIIHRDMKSNNIFL-----HEGLTVKIGDFGLATVKSRWSGSQQV 240 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R N ++ Q+DVYS+G++LY+++ TG + ++ + Sbjct: 241 EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM-TGELPYSHINNRDQIIFMV 299 Query: 1726 IQG-KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G PD K Y P M ++L+ C+K+ +ERP Q IL+S EL+ Sbjct: 300 GRGYASPDLSKLYKNCPKAM-KRLVADCVKKVKEERPLFPQ---ILSSIELL 347 >gi|55961054|emb|CAI13543.1| mitogen-activated protein kinase-activated protein kinase 2 [Homo sapiens] gi|10863901|ref|NP_004750.1| mitogen-activated protein kinase-activated protein kinase 2 isoform 1 [Homo sapiens] gi|627537|pir||JC2204 MAPK-activated protein kinase (EC 2.7.1.-) 2 - human gi|530090|gb|AAA20851.1| MAP kinase activated protein kinase 2 Length = 370 Score = 68.9 bits (167), Expect = 1e-10 Identities = 60/201 (29%), Positives = 92/201 (45%), Gaps = 20/201 (9%) Query: 1572 EFLLAGIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIY 1630 E L AG + ++VME G L R+ + + T I + + ++YLHS I + Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIA-QYCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RD+KP N+L + PNA I K+ D+G A + + T TP + APEV G Y+ Sbjct: 185 RDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYD 241 Query: 1690 QQADVYSFGLLLYDIL--------TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + D++S G+++Y +L G I G+K + E V E Sbjct: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE----- 296 Query: 1742 WPMVEKLIKQCLKENPQERPT 1762 V+ LI+ LK P +R T Sbjct: 297 --EVKMLIRNLLKTEPTQRMT 315 >gi|4502557|ref|NP_001735.1| calcium/calmodulin-dependent protein kinase IV [Homo sapiens] gi|19343925|gb|AAH25687.1| Calcium/calmodulin-dependent protein kinase IV [Homo sapiens] gi|871845|dbj|BAA06403.1| calmodulin-dependent protein kinase IV [Homo sapiens] gi|539546|pir||A53036 Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.123) IV - human gi|2499586|sp|Q16566|KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (CAM kinase-GR) (CaMK IV) gi|306479|gb|AAA35639.1| calcium/calmodulin-dependent protein kinase gi|407006|gb|AAA18251.1| calcium/calmodulin dependent protein kinase Length = 473 Score = 68.9 bits (167), Expect = 1e-10 Identities = 45/125 (36%), Positives = 74/125 (59%), Gaps = 7/125 (5%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LV+EL + G L DR++++ S + + + YLH I++RDLKP N+L Sbjct: 116 LVLELVTGGELFDRIVEKGYYSERDAAD--AVKQILEAVAYLHENGIVHRDLKPENLLYA 173 Query: 1642 TLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700 T P+A + KIAD+G+++ ++ +KT GTPG+ APE+ RG Y + D++S G++ Sbjct: 174 TPAPDAPL--KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRG-CAYGPEVDMWSVGII 230 Query: 1701 LYDIL 1705 Y +L Sbjct: 231 TYILL 235 >gi|32481209|ref|NP_116584.2| mitogen-activated protein kinase-activated protein kinase 2 isoform 2 [Homo sapiens] gi|55961055|emb|CAI13544.1| mitogen-activated protein kinase-activated protein kinase 2 [Homo sapiens] gi|37590438|gb|AAH36060.2| Mitogen-activated protein kinase-activated protein kinase 2, isoform 2 [Homo sapiens] gi|30851683|gb|AAH52584.1| Mitogen-activated protein kinase-activated protein kinase 2, isoform 2 [Homo sapiens] gi|1346538|sp|P49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) gi|38492558|pdb|1NY3|A Chain A, Crystal Structure Of Adp Bound To Map Kap Kinase 2 gi|24158795|pdb|1KWP|B Chain B, Crystal Structure Of Mapkap2 gi|24158794|pdb|1KWP|A Chain A, Crystal Structure Of Mapkap2 Length = 400 Score = 68.9 bits (167), Expect = 1e-10 Identities = 60/201 (29%), Positives = 92/201 (45%), Gaps = 20/201 (9%) Query: 1572 EFLLAGIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIY 1630 E L AG + ++VME G L R+ + + T I + + ++YLHS I + Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIA-QYCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RD+KP N+L + PNA I K+ D+G A + + T TP + APEV G Y+ Sbjct: 185 RDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYD 241 Query: 1690 QQADVYSFGLLLYDIL--------TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + D++S G+++Y +L G I G+K + E V E Sbjct: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE----- 296 Query: 1742 WPMVEKLIKQCLKENPQERPT 1762 V+ LI+ LK P +R T Sbjct: 297 --EVKMLIRNLLKTEPTQRMT 315 >gi|54035072|gb|AAH16695.2| CAMK4 protein [Homo sapiens] Length = 503 Score = 68.9 bits (167), Expect = 1e-10 Identities = 45/125 (36%), Positives = 74/125 (59%), Gaps = 7/125 (5%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LV+EL + G L DR++++ S + + + YLH I++RDLKP N+L Sbjct: 146 LVLELVTGGELFDRIVEKGYYSERDAAD--AVKQILEAVAYLHENGIVHRDLKPENLLYA 203 Query: 1642 TLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700 T P+A + KIAD+G+++ ++ +KT GTPG+ APE+ RG Y + D++S G++ Sbjct: 204 TPAPDAPL--KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRG-CAYGPEVDMWSVGII 260 Query: 1701 LYDIL 1705 Y +L Sbjct: 261 TYILL 265 >gi|4758284|ref|NP_004432.1| ephrin receptor EphB1 precursor [Homo sapiens] gi|1706663|sp|P54762|EPHB1_HUMAN Ephrin type-B receptor 1 precursor (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) gi|1100112|gb|AAB08520.1| protein tyrosine kinase [Homo sapiens] Length = 984 Score = 68.6 bits (166), Expect = 1e-10 Identities = 60/266 (22%), Positives = 121/266 (45%), Gaps = 32/266 (12%) Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 RP M++ E G+LD L+Q+ T + +A G++YL ++RDL N+ Sbjct: 691 RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 750 Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688 L+ N+ ++ K++D+G+++Y + TS+ T + APE + Sbjct: 751 LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK-F 801 Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748 +DV+S+G++++++++ G R + + + +E +LP P+ C + +L Sbjct: 802 TSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPM---DCP--AALHQL 856 Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803 + C +++ RP A++ + L N A L + +P +++ + Sbjct: 857 MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 916 Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829 WL + + SFL T G+TS Sbjct: 917 DDWLSAIKMVQYRDSFL---TAGFTS 939 >gi|19263755|gb|AAH25307.1| PRKD2 protein [Homo sapiens] Length = 538 Score = 68.6 bits (166), Expect = 1e-10 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME L+ +L +K L L + + LR+LH I++ DLKP NVLL + Sbjct: 285 VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 344 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 P + K+ D+G A+ + S GTP + APEV N YN+ D++S G+++ Sbjct: 345 ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 401 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 Y L+ FP DE +I ++ + Y +PW + Sbjct: 402 YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 436 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788 SA D++N+ V + +R + K++ Sbjct: 437 -SAGAIDLINNLLQVKMRKRYSVDKSL 462 >gi|22760266|dbj|BAC11127.1| unnamed protein product [Homo sapiens] Length = 721 Score = 68.6 bits (166), Expect = 1e-10 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME L+ +L +K L L + + LR+LH I++ DLKP NVLL + Sbjct: 468 VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 527 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 P + K+ D+G A+ + S GTP + APEV N YN+ D++S G+++ Sbjct: 528 ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 584 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 Y L+ FP DE +I ++ + Y +PW + Sbjct: 585 YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 619 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788 SA D++N+ V + +R + K++ Sbjct: 620 -SAGAIDLINNLLQVKMRKRYSVDKSL 645 >gi|22761242|dbj|BAC11508.1| unnamed protein product [Homo sapiens] Length = 721 Score = 68.6 bits (166), Expect = 1e-10 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME L+ +L +K L L + + LR+LH I++ DLKP NVLL + Sbjct: 468 VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 527 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 P + K+ D+G A+ + S GTP + APEV N YN+ D++S G+++ Sbjct: 528 ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 584 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 Y L+ FP DE +I ++ + Y +PW + Sbjct: 585 YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 619 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788 SA D++N+ V + +R + K++ Sbjct: 620 -SAGAIDLINNLLQVKMRKRYSVDKSL 645 >gi|7019543|ref|NP_037365.1| serine threonine kinase 39 (STE20/SPS1 homolog, yeast) [Homo sapiens] gi|3851171|gb|AAC72238.1| Ste-20 related kinase SPAK [Homo sapiens] gi|12643880|sp|Q9UEW8|STK39_HUMAN STE20/SPS1-related proline-alanine rich protein kinase (Ste-20 related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 68.6 bits (166), Expect = 1e-10 Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 30/205 (14%) Query: 1583 LVMELASKGSLDRLL-------QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635 LVM+L S GS+ ++ + L + I V +GL YLH I+RDLK Sbjct: 138 LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKA 197 Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688 N+LL +IAD+G++ + G KT GTP + APEV Y Sbjct: 198 GNILL-----GEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGY 252 Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + +AD++SFG+ ++ T V L N+ LE + + +K+YG Sbjct: 253 DFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYG--- 309 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766 KL+ CL+++P +RPT+A++ Sbjct: 310 -KSFRKLLSLCLQKDPSKRPTAAEL 333 >gi|19923468|ref|NP_057541.2| protein kinase D2 [Homo sapiens] gi|12659007|gb|AAK01149.1| protein kinase D2 [Homo sapiens] gi|20138711|sp|Q9BZL6|KPCD2_HUMAN Protein kinase C, D2 type (nPKC-D2) (Protein kinase D2) (HSPC187) Length = 878 Score = 68.6 bits (166), Expect = 1e-10 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME L+ +L +K L L + + LR+LH I++ DLKP NVLL + Sbjct: 625 VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 684 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 P + K+ D+G A+ + S GTP + APEV N YN+ D++S G+++ Sbjct: 685 ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 741 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 Y L+ FP DE +I ++ + Y +PW + Sbjct: 742 YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 776 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788 SA D++N+ V + +R + K++ Sbjct: 777 -SAGAIDLINNLLQVKMRKRYSVDKSL 802 >gi|17736731|emb|CAC84640.1| mixed lineage kinase 4beta [Homo sapiens] gi|24308330|ref|NP_115811.1| mixed lineage kinase 4 [Homo sapiens] Length = 1036 Score = 68.6 bits (166), Expect = 1e-10 Identities = 62/218 (28%), Positives = 108/218 (49%), Gaps = 29/218 (13%) Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627 LV+E A G+L+R L A+ R H + A+ +A G+ YLH Sbjct: 198 LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257 Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683 I++RDLK N+LL + I KI D+G+A+ R ++ GT + APEV + Sbjct: 258 PILHRDLKSSNILLLEEIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317 Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + ++++ +D++S G+LL+++LT R ++GL ++ +P P Sbjct: 318 SS-LFSKGSDIWSCGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 P KL+K+C +++P RP+ A + + L + E +T Sbjct: 371 EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407 >gi|17736729|emb|CAC84639.1| mixed lineage kinase 4alpha [Homo sapiens] Length = 570 Score = 68.6 bits (166), Expect = 1e-10 Identities = 62/218 (28%), Positives = 108/218 (49%), Gaps = 29/218 (13%) Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627 LV+E A G+L+R L A+ R H + A+ +A G+ YLH Sbjct: 198 LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257 Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683 I++RDLK N+LL + I KI D+G+A+ R ++ GT + APEV + Sbjct: 258 PILHRDLKSSNILLLEEIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317 Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + ++++ +D++S G+LL+++LT R ++GL ++ +P P Sbjct: 318 SS-LFSKGSDIWSCGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 P KL+K+C +++P RP+ A + + L + E +T Sbjct: 371 EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407 >gi|27769064|gb|AAH42334.1| Similar to RIKEN cDNA 1300018K11 gene [Homo sapiens] Length = 560 Score = 68.6 bits (166), Expect = 1e-10 Identities = 93/344 (27%), Positives = 154/344 (44%), Gaps = 35/344 (10%) Query: 673 EGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKK---SNS 729 E A GS+ N ++ V F PD+ + +DL+ GS SFL SN Sbjct: 80 ETRAFGSNPNLTKVVFLNTQLCQFRPDAF--GGLPRLEDLEVTGS--SFLNLSTNIFSNL 135 Query: 730 ISVGEFYRDA-VLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK-MSCIANLD 787 S+G+ + +L+ L +H L +L L L N+ + P L + ++ + L+ Sbjct: 136 TSLGKLTLNFNMLEALPEGLFQH-----LAALESLHLQGNRLQALPRRLFQPLTHLKTLN 190 Query: 788 VSRNDIG--PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI 845 +++N + P + P TLK LS N LS +P+ + + L++L L+ N IS + Sbjct: 191 LAQNLLAQLPEELFHPLTSLQTLK---LSNNALSGLPQGVFGKLGSLQELFLDSNNISEL 247 Query: 846 CSPL--RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPF----LPPSMT 899 + +L L+ L L +N I+ L + + + S + N L +P P + Sbjct: 248 PPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLV 307 Query: 900 ILKLSQNKFSCIPEAIL-NLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958 L L+ N+ + E +L +LRSL +S N I +LP L +L N ++ L Sbjct: 308 GLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTAL 367 Query: 959 DLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002 + L S++E L LS N+L +P I D +YNL Sbjct: 368 HPALFQNL-SKLELLSLSKNQLTTLPEGI--------FDTNYNL 402 >gi|4884154|emb|CAB43292.1| hypothetical protein [Homo sapiens] gi|7434268|pir||T08777 probable protein kinase C (EC 2.7.1.-) mu - human (fragment) Length = 542 Score = 68.6 bits (166), Expect = 1e-10 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME L+ +L +K L L + + LR+LH I++ DLKP NVLL + Sbjct: 289 VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 348 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 P + K+ D+G A+ + S GTP + APEV N YN+ D++S G+++ Sbjct: 349 ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 405 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 Y L+ FP DE +I ++ + Y +PW + Sbjct: 406 YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 440 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788 SA D++N+ V + +R + K++ Sbjct: 441 -SAGAIDLINNLLQVKMRKRYSVDKSL 466 >gi|49457444|emb|CAG47021.1| STK17B [Homo sapiens] Length = 372 Score = 68.6 bits (166), Expect = 1e-10 Identities = 52/186 (27%), Positives = 93/186 (50%), Gaps = 12/186 (6%) Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLL 1640 +L++E A+ G + L + A + R+ + +G+ YLH I++ DLKP N+LL Sbjct: 107 ILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILL 166 Query: 1641 FTLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697 ++YP I KI D+G+++ + C ++ GTP + APE+ + I D+++ Sbjct: 167 SSIYPLGDI--KIVDFGMSRKIGHACE--LREIMGTPEYLAPEILNYDPI-TTATDMWNI 221 Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757 G++ Y +LT V N+ L I D +E + + I+ L +NP Sbjct: 222 GIIAYMLLTHTSPFVGE---DNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNP 278 Query: 1758 QERPTS 1763 ++RPT+ Sbjct: 279 EKRPTA 284 >gi|2144413|pir||TVHUBF protein kinase B-raf (EC 2.7.1.-) - human Length = 765 Score = 68.2 bits (165), Expect = 2e-10 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RDLK +N+ L + + KI D+G+A R Sbjct: 555 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 609 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R Y+ Q+DVY+FG++LY+++ TG + ++ + Sbjct: 610 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 668 Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G L PD K P M ++L+ +CLK+ ERP Q IL S EL+ Sbjct: 669 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 716 >gi|12314068|emb|CAC12717.1| GD:STK6 [Homo sapiens] gi|38327570|ref|NP_940838.1| serine/threonine protein kinase 6 [Homo sapiens] gi|38327568|ref|NP_940837.1| serine/threonine protein kinase 6 [Homo sapiens] gi|38327566|ref|NP_940836.1| serine/threonine protein kinase 6 [Homo sapiens] gi|38327564|ref|NP_940835.1| serine/threonine protein kinase 6 [Homo sapiens] gi|38327562|ref|NP_003591.2| serine/threonine protein kinase 6 [Homo sapiens] gi|38327572|ref|NP_940839.1| serine/threonine protein kinase 6 [Homo sapiens] gi|2979628|gb|AAC12708.1| aurora-related kinase 1 [Homo sapiens] Length = 403 Score = 68.2 bits (165), Expect = 2e-10 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 208 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIAD+G + + T GT + PE+ G +++++ D++S G+ Sbjct: 264 L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 318 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 370 QRPMLREVLE 379 >gi|4502553|ref|NP_003647.1| calcium/calmodulin-dependent protein kinase I [Homo sapiens] gi|1362763|pir||S57347 Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.123) I - human gi|3122301|sp|Q14012|KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) gi|790790|gb|AAA99458.1| cam kinase I Length = 370 Score = 68.2 bits (165), Expect = 2e-10 Identities = 56/191 (29%), Positives = 101/191 (52%), Gaps = 22/191 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 L+M+L S G L DR+++ K T R+ V D ++YLH I++RDLKP N+L + Sbjct: 93 LIMQLVSGGELFDRIVE--KGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYY 150 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGI-KTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700 +L ++ I+ I+D+G+++ + T+ GTPG+ APEV Y++ D +S G++ Sbjct: 151 SLDEDSKIM--ISDFGLSKMEDPGSVLSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVI 207 Query: 1701 LYDILTTGGRIVEGLKFPNEFDE--LEIQGKLPDPVKEYGCAPWPMV----EKLIKQCLK 1754 Y IL G +P +DE ++ ++ E+ W + + I+ ++ Sbjct: 208 AY-ILLCG--------YPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLME 258 Query: 1755 ENPQERPTSAQ 1765 ++P++R T Q Sbjct: 259 KDPEKRFTCEQ 269 >gi|51094777|gb|EAL24023.1| v-raf murine sarcoma viral oncogene homolog B1 [Homo sapiens] gi|33188459|ref|NP_004324.2| v-raf murine sarcoma viral oncogene homolog B1 [Homo sapiens] gi|50403720|sp|P15056|BRAF1_HUMAN B-Raf proto-oncogene serine/threonine-protein kinase (p94) (v-Raf murine sarcoma viral oncogene homolog B1) gi|41387220|gb|AAA35609.2| B-raf protein [Homo sapiens] Length = 766 Score = 68.2 bits (165), Expect = 2e-10 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RDLK +N+ L + + KI D+G+A R Sbjct: 556 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 610 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R Y+ Q+DVY+FG++LY+++ TG + ++ + Sbjct: 611 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 669 Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G L PD K P M ++L+ +CLK+ ERP Q IL S EL+ Sbjct: 670 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 717 >gi|56792342|gb|AAW30454.1| AKAP9-BRAF fusion protein [Homo sapiens] Length = 1492 Score = 68.2 bits (165), Expect = 2e-10 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RDLK +N+ L + + KI D+G+A R Sbjct: 1282 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 1336 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R Y+ Q+DVY+FG++LY+++ TG + ++ + Sbjct: 1337 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 1395 Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G L PD K P M ++L+ +CLK+ ERP Q IL S EL+ Sbjct: 1396 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 1443 >gi|12803361|gb|AAH02499.1| STK6 protein [Homo sapiens] gi|20073237|gb|AAH27464.1| Serine/threonine protein kinase 6 [Homo sapiens] gi|13623611|gb|AAH06423.1| Serine/threonine protein kinase 6 [Homo sapiens] gi|12654873|gb|AAH01280.1| Serine/threonine protein kinase 6 [Homo sapiens] gi|27923855|sp|O14965|STK6_HUMAN Serine/threonine-protein kinase 6 (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 68.2 bits (165), Expect = 2e-10 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 208 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIAD+G + + T GT + PE+ G +++++ D++S G+ Sbjct: 264 L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 318 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 370 QRPMLREVLE 379 >gi|19424132|ref|NP_598001.1| NIMA (never in mitosis gene a)-related kinase 7 [Homo sapiens] gi|37537965|sp|Q8TDX7|NEK7_HUMAN Serine/threonine-protein kinase Nek7 (NimA-related protein kinase 7) gi|19032281|dbj|BAB85632.1| NEK7 [Homo sapiens] Length = 302 Score = 68.2 bits (165), Expect = 2e-10 Identities = 50/201 (24%), Positives = 97/201 (48%), Gaps = 32/201 (15%) Query: 1583 LVMELASKGSLDRLLQ---QDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVL 1639 +V+ELA G L R+++ + K + + + + L ++HS +++RD+KP NV Sbjct: 109 IVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVF 168 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSE-----GTPGFRAPEVARGNVIYNQQADV 1694 + A + K+ D G+ ++ KT+ GTP + +PE N YN ++D+ Sbjct: 169 I-----TATGVVKLGDLGLGRF---FSSKTTAAHSLVGTPYYMSPERIHENG-YNFKSDI 219 Query: 1695 YSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPM------VEKL 1748 +S G LLY+ + L+ P D++ + L +++ P P + +L Sbjct: 220 WSLGCLLYE--------MAALQSPFYGDKMNLY-SLCKKIEQCDYPPLPSDHYSEELRQL 270 Query: 1749 IKQCLKENPQERPTSAQVFDI 1769 + C+ +P++RP V+D+ Sbjct: 271 VNMCINPDPEKRPDVTYVYDV 291 >gi|11125348|emb|CAC15059.1| putative protein kinase [Homo sapiens] gi|12711660|ref|NP_061852.1| WNK lysine deficient protein kinase 1 [Homo sapiens] gi|41688795|sp|Q9H4A3|WNK1_HUMAN Serine/threonine-protein kinase WNK1 (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein) Length = 2382 Score = 68.2 bits (165), Expect = 2e-10 Identities = 63/224 (28%), Positives = 106/224 (47%), Gaps = 42/224 (18%) Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624 + F + E + G + +LV EL + G+L L++ K + L+ + GL++LH Sbjct: 281 VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCR-QILKGLQFLH 339 Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682 + II+RDLK N+ F P ++ KI D G+A K+ GTP F APE+ Sbjct: 340 TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMY 395 Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTG-------------GRIVEGLKFPNEFDELEIQGK 1729 Y++ DVY+FG+ + ++ T+ R+ G+K P FD++ I Sbjct: 396 EEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK-PASFDKVAI--- 449 Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773 P V+++I+ C+++N ER + D+LN A Sbjct: 450 -------------PEVKEIIEGCIRQNKDER---YSIKDLLNHA 477 >gi|6933864|gb|AAF31483.1| kinase deficient protein KDP [Homo sapiens] Length = 670 Score = 68.2 bits (165), Expect = 2e-10 Identities = 63/224 (28%), Positives = 106/224 (47%), Gaps = 42/224 (18%) Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624 + F + E + G + +LV EL + G+L L++ K + L+ + GL++LH Sbjct: 281 VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCR-QILKGLQFLH 339 Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682 + II+RDLK N+ F P ++ KI D G+A K+ GTP F APE+ Sbjct: 340 TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMY 395 Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTG-------------GRIVEGLKFPNEFDELEIQGK 1729 Y++ DVY+FG+ + ++ T+ R+ G+K P FD++ I Sbjct: 396 EEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK-PASFDKVAI--- 449 Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773 P V+++I+ C+++N ER + D+LN A Sbjct: 450 -------------PEVKEIIEGCIRQNKDER---YSIKDLLNHA 477 >gi|6851302|gb|AAF29508.1| STK15 serine/threonine kinase [Homo sapiens] gi|3213197|gb|AAC63902.1| serine/threonine kinase [Homo sapiens] Length = 403 Score = 68.2 bits (165), Expect = 2e-10 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 208 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIAD+G + + T GT + PE+ G +++++ D++S G+ Sbjct: 264 L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 318 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 370 QRPMLREVLE 379 >gi|5441948|gb|AAD43193.1| serine/threonine protein kinase; similar to B-raf proto-oncogene; multiple spliced forms; exon 7 is unusually highly conserved at the nucleotide level; similar to Q04982 (PID:g464647) [Homo sapiens] Length = 651 Score = 68.2 bits (165), Expect = 2e-10 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RDLK +N+ L + + KI D+G+A R Sbjct: 441 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 495 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R Y+ Q+DVY+FG++LY+++ TG + ++ + Sbjct: 496 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 554 Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G L PD K P M ++L+ +CLK+ ERP Q IL S EL+ Sbjct: 555 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 602 >gi|4103971|gb|AAD01901.1| Ste20-like protein kinase [Homo sapiens] Length = 547 Score = 68.2 bits (165), Expect = 2e-10 Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 30/205 (14%) Query: 1583 LVMELASKGSLDRLL-------QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635 LVM+L S GS+ ++ + L + I V +GL YLH I+RDLK Sbjct: 138 LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIFKEVLEGLDYLHRNGQIHRDLKA 197 Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688 N+LL +IAD+G++ + G KT GTP + APEV Y Sbjct: 198 GNILL-----GEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGY 252 Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + +AD++SFG+ ++ T V L N+ LE + + +K+YG Sbjct: 253 DFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYG--- 309 Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766 KL+ CL+++P +RPT+A++ Sbjct: 310 -KSFRKLLSLCLQKDPSKRPTAAEL 333 >gi|7446411|pir||JC5974 aurora-related kinase 1 (EC 2.7.-.-) - human Length = 403 Score = 68.2 bits (165), Expect = 2e-10 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 208 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIAD+G + + T GT + PE+ G +++++ D++S G+ Sbjct: 264 L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 318 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 370 QRPMLREVLE 379 >gi|47169341|pdb|1UWH|B Chain B, The Complex Of Wild Type B-Raf And Bay439006 gi|47169340|pdb|1UWH|A Chain A, The Complex Of Wild Type B-Raf And Bay439006 Length = 276 Score = 68.2 bits (165), Expect = 2e-10 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RDLK +N+ L + + KI D+G+A R Sbjct: 109 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 163 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R Y+ Q+DVY+FG++LY+++ TG + ++ + Sbjct: 164 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 222 Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G L PD K P M ++L+ +CLK+ ERP Q IL S EL+ Sbjct: 223 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 270 >gi|37926805|pdb|1MQ4|A Chain A, Crystal Structure Of Aurora-A Protein Kinase Length = 272 Score = 68.2 bits (165), Expect = 2e-10 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 89 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 144 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIAD+G + + T GT + PE+ G +++++ D++S G+ Sbjct: 145 L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 198 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 199 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 250 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 251 QRPMLREVLE 260 >gi|30749504|pdb|1MUO|A Chain A, Crystal Structure Of Aurora-2, An Oncogenic Serine- Threonine Kinase Length = 297 Score = 68.2 bits (165), Expect = 2e-10 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 102 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 157 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIAD+G + + T GT + PE+ G +++++ D++S G+ Sbjct: 158 L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 211 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 212 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 263 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 264 QRPMLREVLE 273 >gi|179535|gb|AAA96495.1| B-raf protein Length = 328 Score = 68.2 bits (165), Expect = 2e-10 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RDLK +N+ L + + KI D+G+A R Sbjct: 118 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 172 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R Y+ Q+DVY+FG++LY+++ TG + ++ + Sbjct: 173 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 231 Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G L PD K P M ++L+ +CLK+ ERP Q IL S EL+ Sbjct: 232 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 279 >gi|20521007|dbj|BAA20802.2| KIAA0344 [Homo sapiens] Length = 2066 Score = 68.2 bits (165), Expect = 2e-10 Identities = 63/224 (28%), Positives = 106/224 (47%), Gaps = 42/224 (18%) Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624 + F + E + G + +LV EL + G+L L++ K + L+ + GL++LH Sbjct: 213 VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCR-QILKGLQFLH 271 Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682 + II+RDLK N+ F P ++ KI D G+A K+ GTP F APE+ Sbjct: 272 TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMY 327 Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTG-------------GRIVEGLKFPNEFDELEIQGK 1729 Y++ DVY+FG+ + ++ T+ R+ G+K P FD++ I Sbjct: 328 EEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK-PASFDKVAI--- 381 Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773 P V+++I+ C+++N ER + D+LN A Sbjct: 382 -------------PEVKEIIEGCIRQNKDER---YSIKDLLNHA 409 >gi|14602490|gb|AAH09751.1| Aurora kinase B [Homo sapiens] Length = 344 Score = 67.8 bits (164), Expect = 2e-10 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 18/186 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 L++E A +G L + LQ+ + I +AD L Y H +I+RD+KP N+LL Sbjct: 152 LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 208 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KIAD+G + + + KT GT + PE+ G ++N++ D++ G+L Y Sbjct: 209 ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 264 Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPM-VEKLIKQCLKENPQER 1760 ++L G E + + ++ K P V PM + LI + L+ NP ER Sbjct: 265 ELL-VGNPPFESASHNETYRRIVKVDLKFPASV--------PMGAQDLISKLLRHNPSER 315 Query: 1761 PTSAQV 1766 AQV Sbjct: 316 LPLAQV 321 >gi|56202636|emb|CAI19991.1| calcium/calmodulin-dependent protein kinase IG [Homo sapiens] gi|21619665|gb|AAH32787.1| Calcium/calmodulin-dependent protein kinase IG [Homo sapiens] gi|14196445|ref|NP_065172.1| calcium/calmodulin-dependent protein kinase IG [Homo sapiens] Length = 476 Score = 67.8 bits (164), Expect = 2e-10 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVM+L S G L DR+L+ + T + V ++YLH I++RDLKP N+L Sbjct: 95 LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 T N+ I+ I D+G+++ + T+ GTPG+ APEV Y++ D +S G++ Sbjct: 153 TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209 Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755 Y IL G +P ++E E + K+ + E+ W + + K L++ Sbjct: 210 Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260 Query: 1756 NPQERPT 1762 +P ER T Sbjct: 261 DPNERYT 267 >gi|1161364|gb|AAB60412.1| tyrosine kinase Length = 527 Score = 67.8 bits (164), Expect = 2e-10 Identities = 51/192 (26%), Positives = 95/192 (49%), Gaps = 16/192 (8%) Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 +P +V E G L L+++K L + + + + +G+ YL I+RDL N Sbjct: 337 KPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQXICEGMEYLERNGYIHRDLAARNC 396 Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTP---GFRAPEVARGNVIYNQQADVY 1695 L+ ++ I KI+D+G+ +Y +S G + PEV N Y+ ++DV+ Sbjct: 397 LV-----SSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK-YSSKSDVW 450 Query: 1696 SFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPM-VEKLIKQCLK 1754 SFG+L++++ T G + F N+ L++ + + + Y PM + +++ C Sbjct: 451 SFGVLMWEVFTEG-----KMPFENK-SNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504 Query: 1755 ENPQERPTSAQV 1766 E P+ RPT A++ Sbjct: 505 EKPEGRPTFAEL 516 >gi|37727961|gb|AAR02359.1| interleukin-1 receptor-associated kinase 4 variant [Homo sapiens] gi|37727959|gb|AAR02358.1| interleukin-1 receptor-associated kinase 4 [Homo sapiens] gi|7020684|dbj|BAA91232.1| unnamed protein product [Homo sapiens] gi|60502299|gb|AAX22228.1| interleukin-1 receptor associated kinase-4 [Homo sapiens] gi|15426432|gb|AAH13316.1| Interleukin-1 receptor-associated kinase 4 [Homo sapiens] gi|26000793|gb|AAN75440.1| interleukin-1 receptor-associated kinase 4 [Homo sapiens] gi|50401181|sp|Q9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase-4 (IRAK-4) (NY-REN-64 antigen) Length = 460 Score = 67.8 bits (164), Expect = 2e-10 Identities = 55/191 (28%), Positives = 95/191 (49%), Gaps = 20/191 (10%) Query: 1593 LDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIA 1651 LDRL D L+ ++ +IA A+G+ +LH I+RD+K N+LL + A A Sbjct: 271 LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL-----DEAFTA 325 Query: 1652 KIADYGIAQYCCRMG--IKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT- 1706 KI+D+G+A+ + + TS GT + APE RG + ++D+YSFG++L +I+T Sbjct: 326 KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 383 Query: 1707 -------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759 +++ +K E +E I+ + + + + + QCL E + Sbjct: 384 LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNK 443 Query: 1760 RPTSAQVFDIL 1770 RP +V +L Sbjct: 444 RPDIKKVQQLL 454 >gi|1848077|emb|CAA26485.1| c-src [Homo sapiens] Length = 351 Score = 67.8 bits (164), Expect = 2e-10 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P +V E SKGSL L+ + R Q +A +A G+ Y+ ++RDL+ N+ Sbjct: 151 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 210 Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690 L+ ++ K+AD+G+A +Y R G K + APE A +Y + Sbjct: 211 LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 258 Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LL ++ T G G+ D++E ++P P + C + L+ Sbjct: 259 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 313 Query: 1750 KQCLKENPQERPT 1762 QC ++ P+ERPT Sbjct: 314 CQCWRKEPEERPT 326 >gi|4758194|ref|NP_004217.1| serine/threonine kinase 17b (apoptosis-inducing) [Homo sapiens] gi|16359143|gb|AAH16040.1| Serine/threonine kinase 17b (apoptosis-inducing) [Homo sapiens] gi|14423909|sp|O94768|ST17B_HUMAN Serine/threonine-protein kinase 17B (DAP kinase-related apoptosis-inducing protein kinase 2) gi|3834356|dbj|BAA34127.1| DRAK2 [Homo sapiens] Length = 372 Score = 67.8 bits (164), Expect = 2e-10 Identities = 52/186 (27%), Positives = 93/186 (50%), Gaps = 12/186 (6%) Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLL 1640 +L++E A+ G + L + A + R+ + +G+ YLH I++ DLKP N+LL Sbjct: 107 ILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILL 166 Query: 1641 FTLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697 ++YP I KI D+G+++ + C ++ GTP + APE+ + I D+++ Sbjct: 167 SSIYPLGDI--KIVDFGMSRKIGHACE--LREIMGTPEYLAPEILNYDPI-TTATDMWNI 221 Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757 G++ Y +LT V N+ L I D +E + + I+ L +NP Sbjct: 222 GIIAYMLLTHTSPFVGE---DNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNP 278 Query: 1758 QERPTS 1763 ++RPT+ Sbjct: 279 EKRPTA 284 >gi|15079460|gb|AAH11566.1| SRC protein [Homo sapiens] gi|55930980|gb|AAH51270.2| Proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] gi|13374724|emb|CAC34523.1| GD:SRC [Homo sapiens] gi|38202217|ref|NP_938033.1| proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] gi|4885609|ref|NP_005408.1| proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] gi|125711|sp|P12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (p60-Src) (c-Src) gi|338460|gb|AAA60584.1| pp60 c-src-1 protein Length = 536 Score = 67.8 bits (164), Expect = 2e-10 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P +V E SKGSL L+ + R Q +A +A G+ Y+ ++RDL+ N+ Sbjct: 336 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 395 Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690 L+ ++ K+AD+G+A +Y R G K + APE A +Y + Sbjct: 396 LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 443 Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LL ++ T G G+ D++E ++P P + C + L+ Sbjct: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 498 Query: 1750 KQCLKENPQERPT 1762 QC ++ P+ERPT Sbjct: 499 CQCWRKEPEERPT 511 >gi|4557511|ref|NP_001339.1| death-associated protein kinase 3 [Homo sapiens] gi|38604691|sp|O43293|DAPK3_HUMAN Death-associated protein kinase 3 (DAP kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) gi|2911156|dbj|BAA24955.1| ZIP-kinase [Homo sapiens] gi|5162884|dbj|BAA81746.1| ZIP kinase [Homo sapiens] Length = 454 Score = 67.8 bits (164), Expect = 2e-10 Identities = 58/186 (31%), Positives = 89/186 (47%), Gaps = 9/186 (4%) Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +L++EL S G L L + K SLT + + DG+ YLHS I + DLKP N++L Sbjct: 90 VLILELVSGGELFDFLAE-KESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL 148 Query: 1642 TL-YPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 PN I K+ D+GIA K GTP F APE+ + +AD++S G+ Sbjct: 149 DKNVPNPRI--KLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPL-GLEADMWSIGV 205 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759 + Y +L+ + K + I D +EY + + I++ L ++P+ Sbjct: 206 ITYILLSGASPFLGETK---QETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKR 262 Query: 1760 RPTSAQ 1765 R T AQ Sbjct: 263 RMTIAQ 268 >gi|33870194|gb|AAH13300.2| AURKB protein [Homo sapiens] Length = 371 Score = 67.8 bits (164), Expect = 2e-10 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 18/186 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 L++E A +G L + LQ+ + I +AD L Y H +I+RD+KP N+LL Sbjct: 179 LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 235 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KIAD+G + + + KT GT + PE+ G ++N++ D++ G+L Y Sbjct: 236 ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 291 Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPM-VEKLIKQCLKENPQER 1760 ++L G E + + ++ K P V PM + LI + L+ NP ER Sbjct: 292 ELL-VGNPPFESASHNETYRRIVKVDLKFPASV--------PMGAQDLISKLLRHNPSER 342 Query: 1761 PTSAQV 1766 AQV Sbjct: 343 LPLAQV 348 >gi|20219010|gb|AAM15772.1| interleukin-1 receptor associated kinase 4 [Homo sapiens] Length = 460 Score = 67.8 bits (164), Expect = 2e-10 Identities = 55/191 (28%), Positives = 95/191 (49%), Gaps = 20/191 (10%) Query: 1593 LDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIA 1651 LDRL D L+ ++ +IA A+G+ +LH I+RD+K N+LL + A A Sbjct: 271 LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL-----DEAFTA 325 Query: 1652 KIADYGIAQYCCRMG--IKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT- 1706 KI+D+G+A+ + + TS GT + APE RG + ++D+YSFG++L +I+T Sbjct: 326 KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 383 Query: 1707 -------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759 +++ +K E +E I+ + + + + + QCL E + Sbjct: 384 LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNK 443 Query: 1760 RPTSAQVFDIL 1770 RP +V +L Sbjct: 444 RPDIKKVQQLL 454 >gi|30271862|gb|AAP29964.1| CLICK III [Homo sapiens] Length = 460 Score = 67.8 bits (164), Expect = 2e-10 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVM+L S G L DR+L+ + T + V ++YLH I++RDLKP N+L Sbjct: 95 LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 T N+ I+ I D+G+++ + T+ GTPG+ APEV Y++ D +S G++ Sbjct: 153 TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209 Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755 Y IL G +P ++E E + K+ + E+ W + + K L++ Sbjct: 210 Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260 Query: 1756 NPQERPT 1762 +P ER T Sbjct: 261 DPNERYT 267 >gi|56205021|emb|CAI22921.1| GD:SRC [Homo sapiens] gi|10436623|dbj|BAB14871.1| unnamed protein product [Homo sapiens] Length = 251 Score = 67.8 bits (164), Expect = 2e-10 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P +V E SKGSL L+ + R Q +A +A G+ Y+ ++RDL+ N+ Sbjct: 51 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 110 Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690 L+ ++ K+AD+G+A +Y R G K + APE A +Y + Sbjct: 111 LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 158 Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LL ++ T G G+ D++E ++P P + C + L+ Sbjct: 159 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 213 Query: 1750 KQCLKENPQERPT 1762 QC ++ P+ERPT Sbjct: 214 CQCWRKEPEERPT 226 >gi|10635153|emb|CAC10573.1| GD:SRC [Homo sapiens] gi|625219|pir||TVHUSC protein-tyrosine kinase (EC 2.7.1.112) src, neuronal - human Length = 542 Score = 67.8 bits (164), Expect = 2e-10 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P +V E SKGSL L+ + R Q +A +A G+ Y+ ++RDL+ N+ Sbjct: 342 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 401 Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690 L+ ++ K+AD+G+A +Y R G K + APE A +Y + Sbjct: 402 LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 449 Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LL ++ T G G+ D++E ++P P + C + L+ Sbjct: 450 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 504 Query: 1750 KQCLKENPQERPT 1762 QC ++ P+ERPT Sbjct: 505 CQCWRKEPEERPT 517 >gi|7023013|dbj|BAA91801.1| unnamed protein product [Homo sapiens] Length = 183 Score = 67.8 bits (164), Expect = 2e-10 Identities = 57/175 (32%), Positives = 89/175 (50%), Gaps = 8/175 (4%) Query: 853 ELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPP---SMTILKLSQNKFS 909 +L L++S+N I + E+ + C ++ N L +P P ++T L ++ Sbjct: 2 QLVELDVSRNEIPEIPES-ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ 60 Query: 910 CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969 +PE I NL +L SL++ N + YLP + L EL +N+I L S A L Sbjct: 61 SLPENIGNLYNLASLELRENLLTYLPDSLT-QLRRLEELDLGNNEIYNLPESIGALL--H 117 Query: 970 VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024 ++ L L N+L E+P EIG L+NL LDVS N L P E+ L+ + DL + + Sbjct: 118 LKDLWLDGNQLSELPQEIGNLKNLLCLDVSEN-RLERLPEEISGLTSLTDLVISQ 171 Score = 57.4 bits (137), Expect = 3e-07 Identities = 50/186 (26%), Positives = 97/186 (52%), Gaps = 15/186 (8%) Query: 831 KLEQLILEGNKISGICSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMNFLA 889 +L +L + N+I I + K L++ + S N ++ L E+F P++++ + Sbjct: 2 QLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESF----PELQNLTCLSVNDI 57 Query: 890 AMPFLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943 ++ LP + + L+L +N + +P+++ L L LD+ +N+I LP + L Sbjct: 58 SLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP-ESIGALL 116 Query: 944 NLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLE 1003 +L++L NQ+S +L ++ + L +S N+L+ +P EI L +LT L +S NL Sbjct: 117 HLKDLWLDGNQLS--ELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNL- 173 Query: 1004 LRSFPN 1009 L + P+ Sbjct: 174 LETIPD 179 Score = 41.2 bits (95), Expect = 0.024 Identities = 38/162 (23%), Positives = 76/162 (46%), Gaps = 25/162 (15%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L++LT L ++ S P + + +A+L++ N + + + D + L++ +L N Sbjct: 46 LQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLL--TYLPDSLTQLRRLEELDLGNN 103 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875 ++ +PE++ ++ L+ L L+GN++S + + LK L L++S+N + L E Sbjct: 104 EIYNLPESIGALLH-LKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLT 162 Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917 S+T L +SQN IP+ + N Sbjct: 163 ---------------------SLTDLVISQNLLETIPDGLEN 183 >gi|4678722|emb|CAB41259.1| hypothetical protein [Homo sapiens] Length = 481 Score = 67.8 bits (164), Expect = 2e-10 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVM+L S G L DR+L+ + T + V ++YLH I++RDLKP N+L Sbjct: 100 LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 157 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 T N+ I+ I D+G+++ + T+ GTPG+ APEV Y++ D +S G++ Sbjct: 158 TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 214 Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755 Y IL G +P ++E E + K+ + E+ W + + K L++ Sbjct: 215 Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 265 Query: 1756 NPQERPT 1762 +P ER T Sbjct: 266 DPNERYT 272 >gi|37727969|gb|AAR02363.1| interleukin-1 receptor-associated kinase 4 short form variant 4 [Homo sapiens] gi|37727967|gb|AAR02362.1| interleukin-1 receptor-associated kinase 4 short form variant 3 [Homo sapiens] gi|37727965|gb|AAR02361.1| interleukin-1 receptor-associated kinase 4 short form variant 2 [Homo sapiens] gi|37727963|gb|AAR02360.1| interleukin-1 receptor-associated kinase 4 short form variant 1 [Homo sapiens] Length = 336 Score = 67.8 bits (164), Expect = 2e-10 Identities = 55/191 (28%), Positives = 95/191 (49%), Gaps = 20/191 (10%) Query: 1593 LDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIA 1651 LDRL D L+ ++ +IA A+G+ +LH I+RD+K N+LL + A A Sbjct: 147 LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL-----DEAFTA 201 Query: 1652 KIADYGIAQYCCRMG--IKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT- 1706 KI+D+G+A+ + + TS GT + APE RG + ++D+YSFG++L +I+T Sbjct: 202 KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 259 Query: 1707 -------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759 +++ +K E +E I+ + + + + + QCL E + Sbjct: 260 LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNK 319 Query: 1760 RPTSAQVFDIL 1770 RP +V +L Sbjct: 320 RPDIKKVQQLL 330 >gi|4507743|ref|NP_003319.1| TXK tyrosine kinase [Homo sapiens] gi|7434388|pir||I84483 protein-tyrosine kinase (EC 2.7.1.112) TXK - human gi|1351326|sp|P42681|TXK_HUMAN Tyrosine-protein kinase TXK gi|684986|gb|AAA74557.1| tyrosine kinase Length = 527 Score = 67.8 bits (164), Expect = 2e-10 Identities = 51/192 (26%), Positives = 95/192 (49%), Gaps = 16/192 (8%) Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 +P +V E G L L+++K L + + + + +G+ YL I+RDL N Sbjct: 337 KPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNC 396 Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTP---GFRAPEVARGNVIYNQQADVY 1695 L+ ++ I KI+D+G+ +Y +S G + PEV N Y+ ++DV+ Sbjct: 397 LV-----SSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK-YSSKSDVW 450 Query: 1696 SFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPM-VEKLIKQCLK 1754 SFG+L++++ T G + F N+ L++ + + + Y PM + +++ C Sbjct: 451 SFGVLMWEVFTEG-----KMPFENK-SNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504 Query: 1755 ENPQERPTSAQV 1766 E P+ RPT A++ Sbjct: 505 EKPEGRPTFAEL 516 >gi|16755792|gb|AAL28100.1| calcium/calmodulin-dependent protein kinase I gamma [Homo sapiens] Length = 476 Score = 67.8 bits (164), Expect = 2e-10 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVM+L S G L DR+L+ + T + V ++YLH I++RDLKP N+L Sbjct: 95 LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 T N+ I+ I D+G+++ + T+ GTPG+ APEV Y++ D +S G++ Sbjct: 153 TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209 Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755 Y IL G +P ++E E + K+ + E+ W + + K L++ Sbjct: 210 Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260 Query: 1756 NPQERPT 1762 +P ER T Sbjct: 261 DPNERYT 267 >gi|47169343|pdb|1UWJ|B Chain B, The Complex Of Mutant V599e B-Raf And Bay439006 gi|47169342|pdb|1UWJ|A Chain A, The Complex Of Mutant V599e B-Raf And Bay439006 Length = 276 Score = 67.8 bits (164), Expect = 2e-10 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667 IA A G+ YLH+ II+RDLK +N+ L + + KI D+G+A R Sbjct: 109 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATEKSRWSGSHQF 163 Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725 + G+ + APEV R Y+ Q+DVY+FG++LY+++ TG + ++ + Sbjct: 164 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 222 Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776 +G L PD K P M ++L+ +CLK+ ERP Q IL S EL+ Sbjct: 223 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 270 >gi|56404655|sp|Q96NX5|KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 67.8 bits (164), Expect = 2e-10 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVM+L S G L DR+L+ + T + V ++YLH I++RDLKP N+L Sbjct: 95 LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 T N+ I+ I D+G+++ + T+ GTPG+ APEV Y++ D +S G++ Sbjct: 153 TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209 Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755 Y IL G +P ++E E + K+ + E+ W + + K L++ Sbjct: 210 Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260 Query: 1756 NPQERPT 1762 +P ER T Sbjct: 261 DPNERYT 267 >gi|5822499|pdb|2SRC| Crystal Structure Of Human Tyrosine-Protein Kinase C-Src, In Complex With Amp-Pnp gi|2392337|pdb|1FMK| Crystal Structure Of Human Tyrosine-Protein Kinase C-Src Length = 452 Score = 67.8 bits (164), Expect = 2e-10 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P +V E SKGSL L+ + R Q +A +A G+ Y+ ++RDL+ N+ Sbjct: 252 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 311 Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690 L+ ++ K+AD+G+A +Y R G K + APE A +Y + Sbjct: 312 LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 359 Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LL ++ T G G+ D++E ++P P + C + L+ Sbjct: 360 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 414 Query: 1750 KQCLKENPQERPT 1762 QC ++ P+ERPT Sbjct: 415 CQCWRKEPEERPT 427 >gi|56208156|emb|CAI22301.1| FYN oncogene related to SRC, FGR, YES [Homo sapiens] gi|23510362|ref|NP_694592.1| protein-tyrosine kinase fyn isoform b [Homo sapiens] Length = 534 Score = 67.4 bits (163), Expect = 3e-10 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%) Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597 T+ ++P+ L + L +D+L + + P +V E +KGSL D L Sbjct: 297 TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 352 Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657 + +L +A VA G+ Y+ I+RDL+ N+L+ +I KIAD+G Sbjct: 353 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 407 Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708 +A +Y R G K + APE A +Y + ++DV+SFG+LL +++T G Sbjct: 408 LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 460 Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 G+ +++E ++P P P + E +I C K++P+ERPT Sbjct: 461 RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 509 >gi|56208155|emb|CAI22300.1| FYN oncogene related to SRC, FGR, YES [Homo sapiens] gi|4503823|ref|NP_002028.1| protein-tyrosine kinase fyn isoform a [Homo sapiens] gi|66783|pir||TVHUSY protein-tyrosine kinase (EC 2.7.1.112) fyn, splice form B [validated] - human gi|181172|gb|AAC08285.1| c-syn protooncogene [Homo sapiens] gi|125370|sp|P06241|FYN_HUMAN Proto-oncogene tyrosine-protein kinase FYN (P59-FYN) (SYN) (SLK) Length = 537 Score = 67.4 bits (163), Expect = 3e-10 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%) Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597 T+ ++P+ L + L +D+L + + P +V E +KGSL D L Sbjct: 300 TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355 Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657 + +L +A VA G+ Y+ I+RDL+ N+L+ +I KIAD+G Sbjct: 356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 410 Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708 +A +Y R G K + APE A +Y + ++DV+SFG+LL +++T G Sbjct: 411 LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 463 Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 G+ +++E ++P P P + E +I C K++P+ERPT Sbjct: 464 RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 512 >gi|5031689|ref|NP_005804.1| protein kinase D3 [Homo sapiens] gi|12230239|sp|O94806|KPCN_HUMAN Protein kinase C, nu type (nPKC-nu) (Protein kinase EPK2) gi|4115769|dbj|BAA36514.1| serine/threonine kinase [Homo sapiens] Length = 890 Score = 67.4 bits (163), Expect = 3e-10 Identities = 56/207 (27%), Positives = 93/207 (44%), Gaps = 30/207 (14%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME L+ +L +K+ L + + + LR LH I++ DLKP NVLL + Sbjct: 650 VVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS 709 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 P + K+ D+G A+ + S GTP + APEV R YN+ D++S G+++ Sbjct: 710 AEPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG-YNRSLDMWSVGVII 766 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 Y L+ FP DE +I ++ + Y PW R Sbjct: 767 YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPPNPW-----------------RE 800 Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788 S + D++N+ V + +R + K++ Sbjct: 801 ISGEAIDLINNLLQVKMRKRYSVDKSL 827 >gi|56208154|emb|CAI22299.1| FYN oncogene related to SRC, FGR, YES [Homo sapiens] Length = 485 Score = 67.4 bits (163), Expect = 3e-10 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%) Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597 T+ ++P+ L + L +D+L + + P +V E +KGSL D L Sbjct: 248 TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 303 Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657 + +L +A VA G+ Y+ I+RDL+ N+L+ +I KIAD+G Sbjct: 304 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 358 Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708 +A +Y R G K + APE A +Y + ++DV+SFG+LL +++T G Sbjct: 359 LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 411 Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 G+ +++E ++P P P + E +I C K++P+ERPT Sbjct: 412 RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 460 >gi|21618480|gb|AAH32496.1| Protein-tyrosine kinase fyn, isoform c [Homo sapiens] gi|23510364|ref|NP_694593.1| protein-tyrosine kinase fyn isoform c [Homo sapiens] Length = 482 Score = 67.4 bits (163), Expect = 3e-10 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%) Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597 T+ ++P+ L + L +D+L + + P +V E +KGSL D L Sbjct: 245 TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 300 Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657 + +L +A VA G+ Y+ I+RDL+ N+L+ +I KIAD+G Sbjct: 301 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 355 Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708 +A +Y R G K + APE A +Y + ++DV+SFG+LL +++T G Sbjct: 356 LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 408 Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 G+ +++E ++P P P + E +I C K++P+ERPT Sbjct: 409 RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 457 >gi|18265389|gb|AAL67158.1| zipper protein kinase [Homo sapiens] Length = 859 Score = 67.0 bits (162), Expect = 4e-10 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 ++ME ++G L +L+ + +T +L ++ +A G+ YLH II+RDLK N+L+ Sbjct: 188 ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 Y + + KI+D+G ++ K S GT + APEV R + +++ D++SFG++L Sbjct: 245 TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300 Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753 +++LT I+ G+ + L + PD K L++QC Sbjct: 301 WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347 Query: 1754 KENPQERPTSAQV 1766 P+ RP+ Q+ Sbjct: 348 NSKPRNRPSFRQI 360 >gi|37181368|gb|AAQ88498.1| densin hlg [Homo sapiens] gi|55665039|emb|CAH72253.1| OTTHUMP00000012531 [Homo sapiens] gi|16307072|gb|AAH09613.1| Hypothetical protein MGC14816 [Homo sapiens] gi|21389431|ref|NP_653221.1| hypothetical protein MGC14816 [Homo sapiens] Length = 335 Score = 67.0 bits (162), Expect = 4e-10 Identities = 70/247 (28%), Positives = 104/247 (42%), Gaps = 55/247 (22%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT-LKQ 810 S+ L L L LH P ++ + + LD+SRN I + P + T L++ Sbjct: 77 SSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE---IPPGIGLLTRLQE 133 Query: 811 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICS-PLRLKELKILNLSKNHISSLSE 869 LSYN++ VP+ L++ LE+L L N+ IC P L L Sbjct: 134 LILSYNKIKTVPKELSNCA-SLEKLELAVNR--DICDLPQELSNLL-------------- 176 Query: 870 NFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSN 929 +T L LS N F+ IP A+LN+P L LDM SN Sbjct: 177 ---------------------------KLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSN 209 Query: 930 DIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC 989 ++ LP + NL L N+I+ L + + L LS+NKL++IP C Sbjct: 210 KLEQLPDTIE-RMQNLHTLWLQRNEITC--LPQTISNMKNLGTLVLSNNKLQDIPV---C 263 Query: 990 LENLTSL 996 +E + +L Sbjct: 264 MEEMANL 270 Score = 51.2 bits (121), Expect = 2e-05 Identities = 34/123 (27%), Positives = 64/123 (52%), Gaps = 3/123 (2%) Query: 900 ILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILD 959 ILK+ + ++ +P ++L L L+ + + +P + NL L S N IS + Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIP-EFIGRFQNLIVLDLSRNTIS--E 120 Query: 960 LSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWD 1019 + L +R+++L LS+NK+K +P E+ +L L+++ N ++ P E+ L K+ Sbjct: 121 IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH 180 Query: 1020 LPL 1022 L L Sbjct: 181 LDL 183 Score = 44.3 bits (103), Expect = 0.003 Identities = 32/109 (29%), Positives = 56/109 (51%), Gaps = 8/109 (7%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L LTHLDL N FT+ P +L M + LD+ N + + D + L L N Sbjct: 175 LLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKL--EQLPDTIERMQNLHTLWLQRN 232 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKN 862 +++ +P+ +++ ++ L L+L NK+ I P+ ++E L+ +N N Sbjct: 233 EITCLPQTISN-MKNLGTLVLSNNKLQDI--PVCMEEMANLRFVNFRDN 278 Score = 39.7 bits (91), Expect = 0.069 Identities = 37/136 (27%), Positives = 62/136 (45%), Gaps = 11/136 (8%) Query: 894 LPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSN-DIQYLPGPAHWKSLNLR 946 +PP + +L LS NK +P+ + N L L+++ N DI LP L L Sbjct: 121 IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELS-NLLKLT 179 Query: 947 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006 L S N + + L+ +E L + NKL+++P I ++NL +L + N E+ Sbjct: 180 HLDLSMNDFTTIPLA--VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRN-EITC 236 Query: 1007 FPNEMGKLSKIWDLPL 1022 P + + + L L Sbjct: 237 LPQTISNMKNLGTLVL 252 >gi|4506075|ref|NP_002733.1| protein kinase D1 [Homo sapiens] gi|1362911|pir||A53215 protein kinase C (EC 2.7.1.-) mu precursor - human gi|2499575|sp|Q15139|KPCM_HUMAN Protein kinase C, mu type (nPKC-mu) (Protein kinase D) gi|438373|emb|CAA53384.1| protein kinase C mu [Homo sapiens] Length = 912 Score = 67.0 bits (162), Expect = 4e-10 Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 13/161 (8%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME L+ +L +K L + + + LR+LH I++ DLKP NVLL + Sbjct: 657 VVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 716 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 P + K+ D+G A+ + S GTP + APEV R N YN+ D++S G+++ Sbjct: 717 ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWSVGVII 773 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPW 1742 Y L+ FP DE +I ++ + Y PW Sbjct: 774 YVSLSG--------TFPFNEDE-DIHDQIQNAAFMYPPNPW 805 >gi|29476775|gb|AAH50050.1| MAP3K12 protein [Homo sapiens] Length = 567 Score = 67.0 bits (162), Expect = 4e-10 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 ++ME ++G L +L+ + +T +L ++ +A G+ YLH II+RDLK N+L+ Sbjct: 221 ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 277 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 Y + + KI+D+G ++ K S GT + APEV R + +++ D++SFG++L Sbjct: 278 TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 333 Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753 +++LT I+ G+ + L + PD K L++QC Sbjct: 334 WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 380 Query: 1754 KENPQERPTSAQV 1766 P+ RP+ Q+ Sbjct: 381 NSKPRNRPSFRQI 393 >gi|56204512|emb|CAI23271.1| protein kinase N2 [Homo sapiens] gi|5453974|ref|NP_006247.1| protein kinase N2 [Homo sapiens] gi|7446420|pir||S67527 protein kinase (EC 2.7.1.-) PRK2 - human gi|1000125|gb|AAC50208.1| PRK2 gi|6225859|sp|Q16513|PKL2_HUMAN Protein kinase N2 (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) gi|914100|gb|AAB33346.1| protein kinase PRK2 [Homo sapiens] gi|1093487|prf||2104208B protein kinase C-related kinase:ISOTYPE=PRK2.3 Length = 984 Score = 67.0 bits (162), Expect = 4e-10 Identities = 59/179 (32%), Positives = 86/179 (48%), Gaps = 17/179 (9%) Query: 1584 VMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643 VME A+ G L + D S R + + A V GL+YLH I+YRDLK N+LL T Sbjct: 736 VMEYAAGGDLMMHIHTDVFSEPRAVFY--AACVVLGLQYLHEHKIVYRDLKLDNLLLDT- 792 Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 KIAD+G+ + G +TS GTP F APEV Y + D + G+L+ Sbjct: 793 ----EGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT-ETSYTRAVDWWGLGVLI 847 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER 1760 Y++L V FP + DE E+ + + Y ++++ L+ NP+ R Sbjct: 848 YEML------VGESPFPGD-DEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERR 899 >gi|55665040|emb|CAH72254.1| OTTHUMP00000012587 [Homo sapiens] Length = 339 Score = 67.0 bits (162), Expect = 4e-10 Identities = 70/247 (28%), Positives = 104/247 (42%), Gaps = 55/247 (22%) Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT-LKQ 810 S+ L L L LH P ++ + + LD+SRN I + P + T L++ Sbjct: 77 SSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE---IPPGIGLLTRLQE 133 Query: 811 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICS-PLRLKELKILNLSKNHISSLSE 869 LSYN++ VP+ L++ LE+L L N+ IC P L L Sbjct: 134 LILSYNKIKTVPKELSNCA-SLEKLELAVNR--DICDLPQELSNLL-------------- 176 Query: 870 NFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSN 929 +T L LS N F+ IP A+LN+P L LDM SN Sbjct: 177 ---------------------------KLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSN 209 Query: 930 DIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC 989 ++ LP + NL L N+I+ L + + L LS+NKL++IP C Sbjct: 210 KLEQLPDTIE-RMQNLHTLWLQRNEITC--LPQTISNMKNLGTLVLSNNKLQDIPV---C 263 Query: 990 LENLTSL 996 +E + +L Sbjct: 264 MEEMANL 270 Score = 51.2 bits (121), Expect = 2e-05 Identities = 34/123 (27%), Positives = 64/123 (52%), Gaps = 3/123 (2%) Query: 900 ILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILD 959 ILK+ + ++ +P ++L L L+ + + +P + NL L S N IS + Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIP-EFIGRFQNLIVLDLSRNTIS--E 120 Query: 960 LSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWD 1019 + L +R+++L LS+NK+K +P E+ +L L+++ N ++ P E+ L K+ Sbjct: 121 IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH 180 Query: 1020 LPL 1022 L L Sbjct: 181 LDL 183 Score = 44.3 bits (103), Expect = 0.003 Identities = 32/109 (29%), Positives = 56/109 (51%), Gaps = 8/109 (7%) Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816 L LTHLDL N FT+ P +L M + LD+ N + + D + L L N Sbjct: 175 LLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKL--EQLPDTIERMQNLHTLWLQRN 232 Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKN 862 +++ +P+ +++ ++ L L+L NK+ I P+ ++E L+ +N N Sbjct: 233 EITCLPQTISN-MKNLGTLVLSNNKLQDI--PVCMEEMANLRFVNFRDN 278 Score = 39.7 bits (91), Expect = 0.069 Identities = 37/136 (27%), Positives = 62/136 (45%), Gaps = 11/136 (8%) Query: 894 LPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSN-DIQYLPGPAHWKSLNLR 946 +PP + +L LS NK +P+ + N L L+++ N DI LP L L Sbjct: 121 IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELS-NLLKLT 179 Query: 947 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006 L S N + + L+ +E L + NKL+++P I ++NL +L + N E+ Sbjct: 180 HLDLSMNDFTTIPLA--VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRN-EITC 236 Query: 1007 FPNEMGKLSKIWDLPL 1022 P + + + L L Sbjct: 237 LPQTISNMKNLGTLVL 252 >gi|2641948|dbj|BAA23592.1| aurora/IPL1-related kinase [Homo sapiens] Length = 402 Score = 67.0 bits (162), Expect = 4e-10 Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 18/188 (9%) Query: 1583 LVMELASKGSLDRLLQQ-DKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 L++E A G++ R LQ+ K RT + +A+ L Y HS +I+RD+KP N+LL Sbjct: 207 LILEYAPLGTVYRELQKLSKFDEQRTAN--LYNRIANALSYCHSKRVIHRDIKPENLLL- 263 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 +A KIAD+G + + T GT + PE+ G +++++ D++S G+L Sbjct: 264 ----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGVLC 318 Query: 1702 YDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER 1760 Y+ L G E + + + ++ PD V E LI + LK NP +R Sbjct: 319 YEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPSQR 370 Query: 1761 PTSAQVFD 1768 P +V + Sbjct: 371 PMLREVLE 378 >gi|47458815|ref|NP_996790.2| protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2 [Homo sapiens] Length = 565 Score = 67.0 bits (162), Expect = 4e-10 Identities = 36/96 (37%), Positives = 58/96 (60%), Gaps = 6/96 (6%) Query: 1611 RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG-IKT 1669 R+ + G+ Y H M+++RDLKP NVLL +A + AKIAD+G++ ++T Sbjct: 135 RLFQQILSGVDYCHRHMVVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFLRT 189 Query: 1670 SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDIL 1705 S G+P + APEV G + + D++S G++LY +L Sbjct: 190 SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 225 >gi|21735552|ref|NP_006292.2| mitogen-activated protein kinase kinase kinase 12 [Homo sapiens] Length = 859 Score = 67.0 bits (162), Expect = 4e-10 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 ++ME ++G L +L+ + +T +L ++ +A G+ YLH II+RDLK N+L+ Sbjct: 188 ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 Y + + KI+D+G ++ K S GT + APEV R + +++ D++SFG++L Sbjct: 245 TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300 Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753 +++LT I+ G+ + L + PD K L++QC Sbjct: 301 WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347 Query: 1754 KENPQERPTSAQV 1766 P+ RP+ Q+ Sbjct: 348 NSKPRNRPSFRQI 360 >gi|29124503|gb|AAH48980.1| PRKAA1 protein [Homo sapiens] Length = 574 Score = 67.0 bits (162), Expect = 4e-10 Identities = 36/96 (37%), Positives = 58/96 (60%), Gaps = 6/96 (6%) Query: 1611 RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG-IKT 1669 R+ + G+ Y H M+++RDLKP NVLL +A + AKIAD+G++ ++T Sbjct: 144 RLFQQILSGVDYCHRHMVVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFLRT 198 Query: 1670 SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDIL 1705 S G+P + APEV G + + D++S G++LY +L Sbjct: 199 SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 234 >gi|4104413|gb|AAD02031.1| Eph-like receptor tyrosine kinase hEphB1b [Homo sapiens] Length = 973 Score = 67.0 bits (162), Expect = 4e-10 Identities = 60/266 (22%), Positives = 119/266 (44%), Gaps = 32/266 (12%) Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 RP M++ E G+LD L+Q+ T + +A G++YL ++RDL N+ Sbjct: 680 RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 739 Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688 L+ N+ ++ K++D+G+++Y + TS+ T + APE + Sbjct: 740 LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK-F 790 Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748 +DV+S+G+ ++++++ G R + + + +E +LP P C + +L Sbjct: 791 TSASDVWSYGIRMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPT---DCP--AALHQL 845 Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803 + C +++ RP A++ + L N A L + +P +++ + Sbjct: 846 MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 905 Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829 WL + + SFL T G+TS Sbjct: 906 DDWLSAIKMVQYRDSFL---TAGFTS 928 >gi|2136035|pir||I38138 protein-serine kinase (EC 2.7.1.-) PSK-H1 - human (fragment) Length = 319 Score = 67.0 bits (162), Expect = 4e-10 Identities = 49/129 (37%), Positives = 74/129 (57%), Gaps = 11/129 (8%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VMELA+ G L DR++ K S T R+ V DG+RYLH+ I +RDLKP N+L + Sbjct: 170 MVMELATGGELFDRIIA--KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYY 227 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG----IKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697 ++ II I D+G+A + G +KT+ GTP + APEV Y D+++ Sbjct: 228 HPGTDSKII--ITDFGLAS-ARKKGDDCLMKTTCGTPEYIAPEVLVRKP-YTNSVDMWAL 283 Query: 1698 GLLLYDILT 1706 G++ Y +L+ Sbjct: 284 GVIAYILLS 292 >gi|631347|pir||JC2363 protein kinase (EC 2.7.1.37) ZPK - human Length = 668 Score = 67.0 bits (162), Expect = 4e-10 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 ++ME ++G L +L+ + +T +L ++ +A G+ YLH II+RDLK N+L+ Sbjct: 188 ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 Y + + KI+D+G ++ K S GT + APEV R + +++ D++SFG++L Sbjct: 245 TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300 Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753 +++LT I+ G+ + L + PD K L++QC Sbjct: 301 WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347 Query: 1754 KENPQERPTSAQV 1766 P+ RP+ Q+ Sbjct: 348 NSKPRNRPSFRQI 360 >gi|18202489|sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (Leucine-zipper protein kinase) (ZPK) gi|561543|gb|AAA67343.1| serine/threonine protein kinase Length = 859 Score = 67.0 bits (162), Expect = 4e-10 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 ++ME ++G L +L+ + +T +L ++ +A G+ YLH II+RDLK N+L+ Sbjct: 188 ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 Y + + KI+D+G ++ K S GT + APEV R + +++ D++SFG++L Sbjct: 245 TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300 Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753 +++LT I+ G+ + L + PD K L++QC Sbjct: 301 WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347 Query: 1754 KENPQERPTSAQV 1766 P+ RP+ Q+ Sbjct: 348 NSKPRNRPSFRQI 360 >gi|20151029|pdb|1KSW|A Chain A, Structure Of Human C-Src Tyrosine Kinase (Thr338gly Mutant) In Complex With N6-Benzyl Adp Length = 452 Score = 67.0 bits (162), Expect = 4e-10 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638 P +V E SKGSL L+ + R Q +A +A G+ Y+ ++RDL+ N+ Sbjct: 252 PIYIVGEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 311 Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690 L+ ++ K+AD+G+A +Y R G K + APE A +Y + Sbjct: 312 LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 359 Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749 ++DV+SFG+LL ++ T G G+ D++E ++P P + C + L+ Sbjct: 360 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 414 Query: 1750 KQCLKENPQERPT 1762 QC ++ P+ERPT Sbjct: 415 CQCWRKEPEERPT 427 >gi|1362858|pir||A56708 MAPK/ERK kinase 5 - human Length = 444 Score = 66.6 bits (161), Expect = 5e-10 Identities = 55/181 (30%), Positives = 80/181 (44%), Gaps = 19/181 (10%) Query: 1586 ELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYP 1645 E GSLD D + + RIA+ V GL YL S I++RD+KP N+L+ Sbjct: 242 EFMDGGSLD-----DIGKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLV----- 291 Query: 1646 NAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDIL 1705 N K+ D+G++ KT GT + APE G Y +DV+S G+ +I Sbjct: 292 NTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQ-YGIHSDVWSLGISFMEIQ 350 Query: 1706 TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQ 1765 G ++ DE PV G P V I QC+++ P+ERP + Sbjct: 351 KNQGSLMPLQLLQCIVDE-------DSPVLPVGEFSEPFVH-FITQCMRKQPKERPAPEE 402 Query: 1766 V 1766 + Sbjct: 403 L 403 >gi|56203182|emb|CAC17574.2| protein kinase, AMP-activated, alpha 2 catalytic subunit [Homo sapiens] gi|47481319|gb|AAH69823.1| AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens] gi|47481295|gb|AAH69680.1| AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens] gi|47479751|gb|AAH69740.1| AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens] gi|46877068|ref|NP_006243.2| AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens] gi|1082205|pir||S51025 [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase (EC 2.7.1.109) - human gi|786491|gb|AAB32732.1| AMP-activated protein kinase, AMPK [human, skeletal muscle, Peptide, 552 aa] gi|20178276|sp|P54646|AAPK2_HUMAN 5'-AMP-activated protein kinase, catalytic alpha-2 chain (AMPK alpha-2 chain) Length = 552 Score = 66.6 bits (161), Expect = 5e-10 Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 9/125 (7%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VME S G L D + + + R+ + + Y H M+++RDLKP NVLL Sbjct: 91 MVMEYVSGGELFDYICKHGRVEEMEA--RRLFQQILSAVDYCHRHMVVHRDLKPENVLL- 147 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700 +A + AKIAD+G++ ++TS G+P + APEV G + + D++S G++ Sbjct: 148 ----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVI 203 Query: 1701 LYDIL 1705 LY +L Sbjct: 204 LYALL 208 >gi|758367|gb|AAA64745.1| AMP-activated protein kinase Length = 552 Score = 66.6 bits (161), Expect = 5e-10 Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 9/125 (7%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 +VME S G L D + + + R+ + + Y H M+++RDLKP NVLL Sbjct: 91 MVMEYVSGGELFDYICKHGRVEEMEA--RRLFQQILSAVDYCHRHMVVHRDLKPENVLL- 147 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700 +A + AKIAD+G++ ++TS G+P + APEV G + + D++S G++ Sbjct: 148 ----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYTAPEVISGRLYAGPEVDIWSCGVI 203 Query: 1701 LYDIL 1705 LY +L Sbjct: 204 LYALL 208 >gi|338228|gb|AAA36615.1| src-like tyrosine kinase (put.); putative Length = 537 Score = 66.6 bits (161), Expect = 5e-10 Identities = 64/234 (27%), Positives = 108/234 (46%), Gaps = 31/234 (13%) Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597 T+ ++P+ L + L +D+L + + P +V E +KGSL D L Sbjct: 300 TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355 Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657 + +L +A VA G+ Y+ I+RDL+ N+L+ +I KIAD+G Sbjct: 356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 410 Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708 +A +Y R G K F A +Y + ++DV+SFG+LL +++T G Sbjct: 411 LARLIEDNEYTARQGAK-------FPIKWTAPERALYGRFTIKSDVWSFGILLTELVTKG 463 Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 G+ +++E ++P P P + E +I C K++P+ERPT Sbjct: 464 RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 512 >gi|37182866|gb|AAQ89233.1| LRRC5 [Homo sapiens] Length = 501 Score = 66.6 bits (161), Expect = 5e-10 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%) Query: 741 LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794 L C +++ + S L L + P+ YLLK + I NL+ N + Sbjct: 163 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 221 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849 + L+ + LK ++ N L+ VP N+TDV L +L++ +G K+ + + + Sbjct: 222 --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 278 Query: 850 RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 + EL++ N I SLS N E K + ++ +T LKL Sbjct: 279 NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 335 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP +I ++ +L SL S+N ++ LP A + LR L S+N IS++ + + Sbjct: 336 NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 392 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 L ++ LH++ NK+ +P ++ L +L++ N + S P ++G+LS++ L L Sbjct: 393 LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 448 Score = 66.6 bits (161), Expect = 5e-10 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%) Query: 683 FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737 +S + + + ++ IPD D F Q D L S+ G FL + N + Sbjct: 38 YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 96 Query: 738 DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797 + ++ ++ R++ +LH + P + ++ +LDV + ++ P Sbjct: 97 EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 146 Query: 798 VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833 + + T L++ +L + SF+ ++L TDV E L Sbjct: 147 KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 206 Query: 834 QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887 +L L E NK+ G+ S L+ LKIL++ K++++ + N + P + + Sbjct: 207 ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 265 Query: 888 --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943 L + L M + L+L + IP AI +L +L+ LD+ SN+I+ + ++ L Sbjct: 266 TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 325 Query: 944 N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002 L L HN+I + S +E L+ S+NKL+ +P + L+ L LDVSYN Sbjct: 326 KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 382 Query: 1003 ELRSFPNEMGKLSKIWDL 1020 + P E+G L + L Sbjct: 383 NISMIPIEIGLLQNLQHL 400 Score = 54.7 bits (130), Expect = 2e-06 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%) Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779 S L K SN V V+ L ++ + ++ L+L + + P + Sbjct: 240 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 299 Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839 +S + LD+ N+I + L L +N++ +P ++T V + LE L Sbjct: 300 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 358 Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896 NK+ + + L++L+ L++S N+IS + L+ + +++ L F Sbjct: 359 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 418 Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935 + L L QN + +PE + L L L++ N + LP Sbjct: 419 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 457 >gi|23241685|gb|AAH34988.1| ULK2 protein [Homo sapiens] Length = 1036 Score = 66.6 bits (161), Expect = 5e-10 Identities = 52/131 (39%), Positives = 70/131 (53%), Gaps = 13/131 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVME + G L LQ T+ R+ LH +A +R LHS II+RDLKP N+LL Sbjct: 83 LVMEYCNGGDLADYLQAKGTLSEDTI--RVFLHQIAAAMRILHSKGIIHRDLKPQNILL- 139 Query: 1642 TLYPN------AAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADV 1694 Y N + I KIAD+G A+Y M T G+P + APEV Y+ +AD+ Sbjct: 140 -SYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQ-HYDAKADL 197 Query: 1695 YSFGLLLYDIL 1705 +S G ++Y L Sbjct: 198 WSIGTVIYQCL 208 >gi|22760350|dbj|BAC11161.1| unnamed protein product [Homo sapiens] Length = 546 Score = 66.6 bits (161), Expect = 5e-10 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814 ++L L + P ++ + + L ++ N + +V+D + LK L Sbjct: 229 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 288 Query: 815 YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865 N LS +P+ +TDV L++L + EG K+ + + L EL+++ I Sbjct: 289 SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 347 Query: 866 --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905 L +N L+ ++ SF N +A +P ++T L+ L++ Sbjct: 348 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 407 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP + LR LD+S N++ +LP NL+ L + N+I L + + Sbjct: 408 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 464 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013 ++ LHL +N L+ +P +G L NLT +++ N L P E+G+ Sbjct: 465 QCRKLRALHLGNNVLRSLPSRVGELTNLTQIELRGN-RLECLPVELGE 511 Score = 59.7 bits (143), Expect = 6e-08 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%) Query: 748 LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807 L + LT + L+LH + P + + L+V + ++ P V + P++ T Sbjct: 149 LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 205 Query: 808 -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843 LK+ L + L+F+ ENL TD+ E LE+L L GN + Sbjct: 206 GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 265 Query: 844 G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889 + LR LK LK+L L K+++S L + + ++ S +N L Sbjct: 266 ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 324 Query: 890 AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946 M ++T L+L + IP +I +L +L+ +D+ N+ I+ + H L Sbjct: 325 KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 380 Query: 947 ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987 +L ++H QI L E+ YL +++EK L LSHN L +P +I Sbjct: 381 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 440 Query: 988 GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 G L+NL +L ++ N + + P E+ + K+ L L Sbjct: 441 GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 474 >gi|55663684|emb|CAH72226.1| leucine rich repeat containing 5 [Homo sapiens] gi|34222199|ref|NP_060573.2| leucine rich repeat containing 5 [Homo sapiens] gi|33988925|gb|AAH24159.2| Leucine rich repeat containing 5 [Homo sapiens] gi|51701663|sp|Q7L1W4|LRR5_HUMAN Leucine-rich repeat-containing protein 5 precursor (UNQ213/PRO239) Length = 858 Score = 66.6 bits (161), Expect = 5e-10 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%) Query: 741 LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794 L C +++ + S L L + P+ YLLK + I NL+ N + Sbjct: 520 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 578 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849 + L+ + LK ++ N L+ VP N+TDV L +L++ +G K+ + + + Sbjct: 579 --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 635 Query: 850 RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 + EL++ N I SLS N E K + ++ +T LKL Sbjct: 636 NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 692 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP +I ++ +L SL S+N ++ LP A + LR L S+N IS++ + + Sbjct: 693 NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 749 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 L ++ LH++ NK+ +P ++ L +L++ N + S P ++G+LS++ L L Sbjct: 750 LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 805 Score = 66.6 bits (161), Expect = 5e-10 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%) Query: 683 FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737 +S + + + ++ IPD D F Q D L S+ G FL + N + Sbjct: 395 YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 453 Query: 738 DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797 + ++ ++ R++ +LH + P + ++ +LDV + ++ P Sbjct: 454 EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 503 Query: 798 VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833 + + T L++ +L + SF+ ++L TDV E L Sbjct: 504 KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 563 Query: 834 QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887 +L L E NK+ G+ S L+ LKIL++ K++++ + N + P + + Sbjct: 564 ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 622 Query: 888 --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943 L + L M + L+L + IP AI +L +L+ LD+ SN+I+ + ++ L Sbjct: 623 TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682 Query: 944 N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002 L L HN+I + S +E L+ S+NKL+ +P + L+ L LDVSYN Sbjct: 683 KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 739 Query: 1003 ELRSFPNEMGKLSKIWDL 1020 + P E+G L + L Sbjct: 740 NISMIPIEIGLLQNLQHL 757 Score = 54.7 bits (130), Expect = 2e-06 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%) Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779 S L K SN V V+ L ++ + ++ L+L + + P + Sbjct: 597 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656 Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839 +S + LD+ N+I + L L +N++ +P ++T V + LE L Sbjct: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 715 Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896 NK+ + + L++L+ L++S N+IS + L+ + +++ L F Sbjct: 716 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775 Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935 + L L QN + +PE + L L L++ N + LP Sbjct: 776 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814 >gi|7022525|dbj|BAA91631.1| unnamed protein product [Homo sapiens] Length = 682 Score = 66.6 bits (161), Expect = 5e-10 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%) Query: 741 LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794 L C +++ + S L L + P+ YLLK + I NL+ N + Sbjct: 344 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 402 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849 + L+ + LK ++ N L+ VP N+TDV L +L++ +G K+ + + + Sbjct: 403 --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 459 Query: 850 RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 + EL++ N I SLS N E K + ++ +T LKL Sbjct: 460 NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 516 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP +I ++ +L SL S+N ++ LP A + LR L S+N IS++ + + Sbjct: 517 NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 573 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 L ++ LH++ NK+ +P ++ L +L++ N + S P ++G+LS++ L L Sbjct: 574 LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 629 Score = 66.6 bits (161), Expect = 5e-10 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%) Query: 683 FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737 +S + + + ++ IPD D F Q D L S+ G FL + N + Sbjct: 219 YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 277 Query: 738 DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797 + ++ ++ R++ +LH + P + ++ +LDV + ++ P Sbjct: 278 EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 327 Query: 798 VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833 + + T L++ +L + SF+ ++L TDV E L Sbjct: 328 KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 387 Query: 834 QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887 +L L E NK+ G+ S L+ LKIL++ K++++ + N + P + + Sbjct: 388 ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 446 Query: 888 --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943 L + L M + L+L + IP AI +L +L+ LD+ SN+I+ + ++ L Sbjct: 447 TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 506 Query: 944 N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002 L L HN+I + S +E L+ S+NKL+ +P + L+ L LDVSYN Sbjct: 507 KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 563 Query: 1003 ELRSFPNEMGKLSKIWDL 1020 + P E+G L + L Sbjct: 564 NISMIPIEIGLLQNLQHL 581 Score = 54.7 bits (130), Expect = 2e-06 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%) Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779 S L K SN V V+ L ++ + ++ L+L + + P + Sbjct: 421 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 480 Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839 +S + LD+ N+I + L L +N++ +P ++T V + LE L Sbjct: 481 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 539 Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896 NK+ + + L++L+ L++S N+IS + L+ + +++ L F Sbjct: 540 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 599 Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935 + L L QN + +PE + L L L++ N + LP Sbjct: 600 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 638 >gi|40788306|dbj|BAA31598.2| KIAA0623 protein [Homo sapiens] Length = 1100 Score = 66.6 bits (161), Expect = 5e-10 Identities = 52/131 (39%), Positives = 70/131 (53%), Gaps = 13/131 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVME + G L LQ T+ R+ LH +A +R LHS II+RDLKP N+LL Sbjct: 147 LVMEYCNGGDLADYLQAKGTLSEDTI--RVFLHQIAAAMRILHSKGIIHRDLKPQNILL- 203 Query: 1642 TLYPN------AAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADV 1694 Y N + I KIAD+G A+Y M T G+P + APEV Y+ +AD+ Sbjct: 204 -SYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQ-HYDAKADL 261 Query: 1695 YSFGLLLYDIL 1705 +S G ++Y L Sbjct: 262 WSIGTVIYQCL 272 >gi|23199985|ref|NP_055498.2| unc-51-like kinase 2 [Homo sapiens] Length = 1036 Score = 66.6 bits (161), Expect = 5e-10 Identities = 52/131 (39%), Positives = 70/131 (53%), Gaps = 13/131 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVME + G L LQ T+ R+ LH +A +R LHS II+RDLKP N+LL Sbjct: 83 LVMEYCNGGDLADYLQAKGTLSEDTI--RVFLHQIAAAMRILHSKGIIHRDLKPQNILL- 139 Query: 1642 TLYPN------AAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADV 1694 Y N + I KIAD+G A+Y M T G+P + APEV Y+ +AD+ Sbjct: 140 -SYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQ-HYDAKADL 197 Query: 1695 YSFGLLLYDIL 1705 +S G ++Y L Sbjct: 198 WSIGTVIYQCL 208 >gi|4758700|ref|NP_004626.1| mitogen-activated protein kinase-activated protein kinase 3 [Homo sapiens] gi|14714545|gb|AAH10407.1| Mitogen-activated protein kinase-activated protein kinase 3 [Homo sapiens] gi|12804503|gb|AAH01662.1| Mitogen-activated protein kinase-activated protein kinase 3 [Homo sapiens] gi|14043206|gb|AAH07591.1| Mitogen-activated protein kinase-activated protein kinase 3 [Homo sapiens] gi|7434272|pir||JC6094 MAPK-activated protein kinase (EC 2.7.1.-) 3 - human gi|1209018|gb|AAD09136.1| MAPKAP kinase [Homo sapiens] gi|1256005|gb|AAC50428.1| mitogen activated protein kinase activated protein kinase-3 gi|1589557|prf||2211336A MAP kinase-activated protein kinase 3 gi|1588508|prf||2208434A 3pK protein Length = 382 Score = 66.6 bits (161), Expect = 5e-10 Identities = 60/208 (28%), Positives = 97/208 (46%), Gaps = 39/208 (18%) Query: 1577 GIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635 G R +++ME G L R+ ++ + T I + +++LHS I +RD+KP Sbjct: 110 GKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKP 169 Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVY 1695 N LL+T A++ K+ D+G A+ + ++T TP + APEV G Y++ D++ Sbjct: 170 EN-LLYTSKEKDAVL-KLTDFGFAKETTQNALQTPCYTPYYVAPEVL-GPEKYDKSCDMW 226 Query: 1696 SFGLLLYDIL--------TTGGRIVEGLK---------FPN-EFDELEIQGKLPDPVKEY 1737 S G+++Y +L TG I G+K FPN E+ E+ K Sbjct: 227 SLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAK-------- 278 Query: 1738 GCAPWPMVEKLIKQCLKENPQERPTSAQ 1765 +LI+ LK +P ER T Q Sbjct: 279 ---------QLIRLLLKTDPTERLTITQ 297 >gi|52545731|emb|CAH56273.1| hypothetical protein [Homo sapiens] Length = 805 Score = 66.6 bits (161), Expect = 5e-10 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%) Query: 741 LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794 L C +++ + S L L + P+ YLLK + I NL+ N + Sbjct: 467 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 525 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849 + L+ + LK ++ N L+ VP N+TDV L +L++ +G K+ + + + Sbjct: 526 --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 582 Query: 850 RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 + EL++ N I SLS N E K + ++ +T LKL Sbjct: 583 NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 639 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP +I ++ +L SL S+N ++ LP A + LR L S+N IS++ + + Sbjct: 640 NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 696 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 L ++ LH++ NK+ +P ++ L +L++ N + S P ++G+LS++ L L Sbjct: 697 LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 752 Score = 66.6 bits (161), Expect = 5e-10 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%) Query: 683 FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737 +S + + + ++ IPD D F Q D L S+ G FL + N + Sbjct: 342 YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 400 Query: 738 DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797 + ++ ++ R++ +LH + P + ++ +LDV + ++ P Sbjct: 401 EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 450 Query: 798 VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833 + + T L++ +L + SF+ ++L TDV E L Sbjct: 451 KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 510 Query: 834 QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887 +L L E NK+ G+ S L+ LKIL++ K++++ + N + P + + Sbjct: 511 ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 569 Query: 888 --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943 L + L M + L+L + IP AI +L +L+ LD+ SN+I+ + ++ L Sbjct: 570 TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 629 Query: 944 N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002 L L HN+I + S +E L+ S+NKL+ +P + L+ L LDVSYN Sbjct: 630 KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 686 Query: 1003 ELRSFPNEMGKLSKIWDL 1020 + P E+G L + L Sbjct: 687 NISMIPIEIGLLQNLQHL 704 Score = 54.7 bits (130), Expect = 2e-06 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%) Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779 S L K SN V V+ L ++ + ++ L+L + + P + Sbjct: 544 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 603 Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839 +S + LD+ N+I + L L +N++ +P ++T V + LE L Sbjct: 604 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 662 Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896 NK+ + + L++L+ L++S N+IS + L+ + +++ L F Sbjct: 663 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 722 Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935 + L L QN + +PE + L L L++ N + LP Sbjct: 723 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 761 >gi|52545685|emb|CAH56285.1| hypothetical protein [Homo sapiens] Length = 819 Score = 66.6 bits (161), Expect = 5e-10 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%) Query: 741 LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794 L C +++ + S L L + P+ YLLK + I NL+ N + Sbjct: 481 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 539 Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849 + L+ + LK ++ N L+ VP N+TDV L +L++ +G K+ + + + Sbjct: 540 --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 596 Query: 850 RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905 + EL++ N I SLS N E K + ++ +T LKL Sbjct: 597 NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 653 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP +I ++ +L SL S+N ++ LP A + LR L S+N IS++ + + Sbjct: 654 NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 710 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 L ++ LH++ NK+ +P ++ L +L++ N + S P ++G+LS++ L L Sbjct: 711 LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 766 Score = 66.6 bits (161), Expect = 5e-10 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%) Query: 683 FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737 +S + + + ++ IPD D F Q D L S+ G FL + N + Sbjct: 356 YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 414 Query: 738 DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797 + ++ ++ R++ +LH + P + ++ +LDV + ++ P Sbjct: 415 EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 464 Query: 798 VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833 + + T L++ +L + SF+ ++L TDV E L Sbjct: 465 KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 524 Query: 834 QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887 +L L E NK+ G+ S L+ LKIL++ K++++ + N + P + + Sbjct: 525 ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 583 Query: 888 --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943 L + L M + L+L + IP AI +L +L+ LD+ SN+I+ + ++ L Sbjct: 584 TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 643 Query: 944 N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002 L L HN+I + S +E L+ S+NKL+ +P + L+ L LDVSYN Sbjct: 644 KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 700 Query: 1003 ELRSFPNEMGKLSKIWDL 1020 + P E+G L + L Sbjct: 701 NISMIPIEIGLLQNLQHL 718 Score = 54.7 bits (130), Expect = 2e-06 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%) Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779 S L K SN V V+ L ++ + ++ L+L + + P + Sbjct: 558 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 617 Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839 +S + LD+ N+I + L L +N++ +P ++T V + LE L Sbjct: 618 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 676 Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896 NK+ + + L++L+ L++S N+IS + L+ + +++ L F Sbjct: 677 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 736 Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935 + L L QN + +PE + L L L++ N + LP Sbjct: 737 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 775 >gi|9247171|gb|AAB33113.2| tyrosine kinase p59fyn(T) [Homo sapiens] Length = 534 Score = 66.6 bits (161), Expect = 5e-10 Identities = 64/234 (27%), Positives = 108/234 (46%), Gaps = 31/234 (13%) Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597 T+ ++P+ L + L +D+L + + P +V E +KGSL D L Sbjct: 297 TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 352 Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657 + +L +A VA G+ Y+ I+RDL+ N+L+ +I KIAD+G Sbjct: 353 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 407 Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708 +A +Y R G K F A +Y + ++DV+SFG+LL +++T G Sbjct: 408 LARLIEDNEYTARQGAK-------FPIKWTAPERALYGRFTIKSDVWSFGILLTELVTKG 460 Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 G+ +++E ++P P P + E +I C K++P+ERPT Sbjct: 461 RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 509 >gi|5688866|dbj|BAA82709.1| Aik2 [Homo sapiens] Length = 343 Score = 66.6 bits (161), Expect = 5e-10 Identities = 55/185 (29%), Positives = 86/185 (46%), Gaps = 17/185 (9%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 L++E A +G L + LQ+ + I +AD L Y H +I+RD+KP N+LL Sbjct: 152 LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 208 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KIAD+G + + + KT GT + PE+ G I N++ D++ G+L Y Sbjct: 209 ---GLKGELKIADFGWSVHATSLRRKTMCGTLDYLPPEMIEGR-IDNEKVDLWCIGVLCY 264 Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 ++L G E + + ++ K P V + LI + L+ NP ER Sbjct: 265 ELLV--GNPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSERL 315 Query: 1762 TSAQV 1766 AQV Sbjct: 316 PLAQV 320 >gi|29029632|ref|NP_004295.2| anaplastic lymphoma kinase Ki-1 [Homo sapiens] Length = 1620 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 1191 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 1250 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 1251 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 1308 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 1309 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 1363 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 1364 QCWQHQPEDRPNFAIILE 1381 >gi|14042212|dbj|BAB55153.1| unnamed protein product [Homo sapiens] Length = 474 Score = 66.2 bits (160), Expect = 7e-10 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814 ++L L + P ++ + + L ++ N + +V+D + LK L Sbjct: 157 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 216 Query: 815 YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865 N LS +P+ +TDV L++L + EG K+ + + L EL+++ I Sbjct: 217 SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 275 Query: 866 --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905 L +N L+ ++ SF N +A +P ++T L+ L++ Sbjct: 276 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 335 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP + LR LD+S N++ +LP NL+ L + N+I L + + Sbjct: 336 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 392 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013 ++ LHL +N L+ +P +G L NLT +++ N L P E+G+ Sbjct: 393 QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 439 Score = 59.7 bits (143), Expect = 6e-08 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%) Query: 748 LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807 L + LT + L+LH + P + + L+V + ++ P V + P++ T Sbjct: 77 LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 133 Query: 808 -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843 LK+ L + L+F+ ENL TD+ E LE+L L GN + Sbjct: 134 GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 193 Query: 844 G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889 + LR LK LK+L L K+++S L + + ++ S +N L Sbjct: 194 ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 252 Query: 890 AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946 M ++T L+L + IP +I +L +L+ +D+ N+ I+ + H L Sbjct: 253 KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 308 Query: 947 ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987 +L ++H QI L E+ YL +++EK L LSHN L +P +I Sbjct: 309 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 368 Query: 988 GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 G L+NL +L ++ N + + P E+ + K+ L L Sbjct: 369 GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 402 >gi|13186236|ref|NP_075594.1| fibroblast growth factor receptor 1 isoform 4 precursor [Homo sapiens] gi|60552859|gb|AAH91494.1| FGFR1 protein [Homo sapiens] gi|31387|emb|CAA40404.1| Fibroblast Growth Factor Receptor, 2 Ig-Domain Form [Homo sapiens] Length = 731 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 465 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 524 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 525 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 579 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 580 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 635 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 636 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 670 >gi|37181692|gb|AAQ88653.1| RQTI221 [Homo sapiens] gi|39930379|ref|NP_062540.1| leucine rich repeat containing 8 [Homo sapiens] Length = 546 Score = 66.2 bits (160), Expect = 7e-10 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814 ++L L + P ++ + + L ++ N + +V+D + LK L Sbjct: 229 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 288 Query: 815 YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865 N LS +P+ +TDV L++L + EG K+ + + L EL+++ I Sbjct: 289 SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 347 Query: 866 --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905 L +N L+ ++ SF N +A +P ++T L+ L++ Sbjct: 348 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 407 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP + LR LD+S N++ +LP NL+ L + N+I L + + Sbjct: 408 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 464 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013 ++ LHL +N L+ +P +G L NLT +++ N L P E+G+ Sbjct: 465 QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 511 Score = 59.7 bits (143), Expect = 6e-08 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%) Query: 748 LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807 L + LT + L+LH + P + + L+V + ++ P V + P++ T Sbjct: 149 LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 205 Query: 808 -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843 LK+ L + L+F+ ENL TD+ E LE+L L GN + Sbjct: 206 GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 265 Query: 844 G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889 + LR LK LK+L L K+++S L + + ++ S +N L Sbjct: 266 ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 324 Query: 890 AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946 M ++T L+L + IP +I +L +L+ +D+ N+ I+ + H L Sbjct: 325 KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 380 Query: 947 ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987 +L ++H QI L E+ YL +++EK L LSHN L +P +I Sbjct: 381 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 440 Query: 988 GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 G L+NL +L ++ N + + P E+ + K+ L L Sbjct: 441 GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 474 >gi|11276087|ref|NP_000595.1| fibroblast growth factor receptor 1 isoform 1 precursor [Homo sapiens] gi|35110|emb|CAA47375.1| fibroblast growth factor receptor [Homo sapiens] gi|31393|emb|CAA40403.1| Fibroblast Growth Factor Receptor, 3-Ig Domain+2 AA insert [Homo sapiens] gi|476559|pir||TVHUFG fibroblast growth factor receptor 1 precursor - human gi|45934432|gb|AAS79322.1| fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) [Homo sapiens] gi|120046|sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase-2) (c-fgr) gi|31378|emb|CAA37015.1| unnamed protein product [Homo sapiens] Length = 822 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 556 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 615 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 616 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 671 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 726 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 727 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 761 >gi|31368|emb|CAA36101.1| unnamed protein product [Homo sapiens] Length = 822 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 556 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 615 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 616 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 671 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 726 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 727 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 761 >gi|179415|gb|AAA75007.1| basic fibroblast growth factor receptor protein Length = 731 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 465 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 524 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 525 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 579 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 580 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 635 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 636 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 670 >gi|13186251|ref|NP_056934.2| fibroblast growth factor receptor 1 isoform 2 precursor [Homo sapiens] gi|31391|emb|CAA40402.1| Fibroblast Growth Factor Receptor, 3 Ig-Domain Form [Homo sapiens] gi|182561|gb|AAA35840.1| fibroblast growth factor receptor Length = 820 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 554 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 614 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 669 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 725 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759 >gi|182534|gb|AAA35837.1| fibroblast growth factor receptor (FGFr) transmembrane form Length = 731 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 465 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 524 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 525 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 579 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 580 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 635 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 636 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 670 >gi|13186234|ref|NP_075593.1| fibroblast growth factor receptor 1 isoform 3 precursor [Homo sapiens] gi|31389|emb|CAA40401.1| Fibroblast Growth Factor Receptor, 2-Ig Domain+2 AA insert [Homo sapiens] gi|182532|gb|AAA35836.1| fibroblast growth factor receptor (FGFr) transmembrane form Length = 733 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 467 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 526 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 527 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 581 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 582 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 637 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 638 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 672 >gi|37181710|gb|AAQ88662.1| SAPS287 [Homo sapiens] Length = 1059 Score = 66.2 bits (160), Expect = 7e-10 Identities = 63/230 (27%), Positives = 108/230 (46%), Gaps = 42/230 (18%) Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKNH 863 +L++ L+ N+L +P NL V + L L GN+I I P LKE L+ L+LS N+ Sbjct: 39 SLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEIL-PEHLKEFQSLETLDLSSNN 96 Query: 864 ISSLSENFLEACPKVESFSARMNFLAAMP-----FLPPSMTILKLSQNKFSCIPEAILNL 918 IS L F +++ N + +M L ++ +LKL++N+ S IP + L Sbjct: 97 ISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKL 154 Query: 919 PHLRSLDMSSNDIQYLPG------------------------PAHWKSLNLRELLFSHNQ 954 P L+ L+++ N I+ + G A W N+ L HN Sbjct: 155 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 214 Query: 955 ISILDLSEKAYLWS--RVEKLHLSHNKLKEIPPEI-GCLENLTSLDVSYN 1001 ++ + K +L+ +++LHLS N + I P+ + L+ LD+++N Sbjct: 215 LTEI---TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFN 261 Score = 52.4 bits (124), Expect = 1e-05 Identities = 67/286 (23%), Positives = 125/286 (43%), Gaps = 30/286 (10%) Query: 759 SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818 +L L L+ N+ ++ P + K+ + +L+++RN I +V LK + N + Sbjct: 133 TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKI-KNVDGLTFQGLGALKSLKMQRNGV 191 Query: 819 SFVPENLTDVVEKLEQLILEGNKISGICSP--LRLKELKILNLSKNHISSLSENFLEACP 876 + + + + +E L L+ N ++ I L L+ L+LS+N I+ +S + E C Sbjct: 192 TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 251 Query: 877 KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936 K+ N L+ +L + F L L L +L + +N + Y+ Sbjct: 252 KLSELDLTFNHLS------------RLDDSSF-------LGLSLLNTLHIGNNRVSYIAD 292 Query: 937 PAHWKSLNLRELLFSHNQIS--ILDLSEKAYLWSRVEKLHLSHNKLKEIPPE-IGCLENL 993 A +L+ L +N+IS I D++ ++ +L L N+++ I + L+ L Sbjct: 293 CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 352 Query: 994 TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAK 1039 LD+S N + N ++ K L +LHLN C+ K Sbjct: 353 EHLDLSDNAIMSLQGNAFSQMKK-----LQQLHLNTSSLLCDCQLK 393 >gi|30410930|gb|AAH51322.1| LRRC8 protein [Homo sapiens] gi|27462054|gb|AAN18279.1| leucine-rich repeat-containing 8 [Homo sapiens] gi|55859580|emb|CAI10839.1| leucine rich repeat containing 8 [Homo sapiens] gi|37537912|sp|Q8IWT6|LRR8_HUMAN Leucine-rich repeat-containing protein 8 precursor Length = 810 Score = 66.2 bits (160), Expect = 7e-10 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814 ++L L + P ++ + + L ++ N + +V+D + LK L Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552 Query: 815 YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865 N LS +P+ +TDV L++L + EG K+ + + L EL+++ I Sbjct: 553 SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611 Query: 866 --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905 L +N L+ ++ SF N +A +P ++T L+ L++ Sbjct: 612 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP + LR LD+S N++ +LP NL+ L + N+I L + + Sbjct: 672 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 728 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013 ++ LHL +N L+ +P +G L NLT +++ N L P E+G+ Sbjct: 729 QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 775 Score = 59.7 bits (143), Expect = 6e-08 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%) Query: 748 LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807 L + LT + L+LH + P + + L+V + ++ P V + P++ T Sbjct: 413 LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 469 Query: 808 -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843 LK+ L + L+F+ ENL TD+ E LE+L L GN + Sbjct: 470 GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 529 Query: 844 G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889 + LR LK LK+L L K+++S L + + ++ S +N L Sbjct: 530 ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588 Query: 890 AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946 M ++T L+L + IP +I +L +L+ +D+ N+ I+ + H L Sbjct: 589 KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644 Query: 947 ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987 +L ++H QI L E+ YL +++EK L LSHN L +P +I Sbjct: 645 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 704 Query: 988 GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 G L+NL +L ++ N + + P E+ + K+ L L Sbjct: 705 GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 738 >gi|38197155|gb|AAH00442.2| AURKB protein [Homo sapiens] Length = 364 Score = 66.2 bits (160), Expect = 7e-10 Identities = 54/185 (29%), Positives = 87/185 (47%), Gaps = 16/185 (8%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 L++E A +G L + LQ+ + I +AD L Y H +I+RD+KP N+LL Sbjct: 172 LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 228 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KIAD+G + + + KT GT + PE+ G ++N++ D++ G+L Y Sbjct: 229 ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 284 Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 ++L G E + + ++ K P V + LI + L+ NP ER Sbjct: 285 ELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSERL 336 Query: 1762 TSAQV 1766 AQV Sbjct: 337 PLAQV 341 >gi|21955340|gb|AAH15035.1| FGFR1 protein [Homo sapiens] Length = 820 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 554 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 614 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 669 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 725 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759 >gi|17939640|gb|AAH19334.1| Serine/threonine protein kinase 11 [Homo sapiens] gi|14124918|gb|AAH07981.1| Serine/threonine protein kinase 11 [Homo sapiens] gi|4507271|ref|NP_000446.1| serine/threonine protein kinase 11 [Homo sapiens] gi|2754827|gb|AAC39527.1| serine threonine kinase 11 [Homo sapiens] gi|3063585|gb|AAC15742.1| Peutz-Jeghers syndrome protein [Homo sapiens] gi|2791676|gb|AAB97833.1| serine threonine kinase 11 [Homo sapiens] gi|1480861|gb|AAB05809.1| serine/threonine protein kinase [Homo sapiens] gi|3024670|sp|Q15831|STK11_HUMAN Serine/threonine-protein kinase 11 (Serine/threonine-protein kinase LKB1) Length = 433 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/189 (30%), Positives = 90/189 (47%), Gaps = 17/189 (8%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME G + L + H + DGL YLHS I+++D+KP N+LL T Sbjct: 127 MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTT 186 Query: 1643 LYPNAAIIAKIADYGIAQ----YCCRMGIKTSEGTPGFRAPEVARG-NVIYNQQADVYSF 1697 KI+D G+A+ + +TS+G+P F+ PE+A G + + D++S Sbjct: 187 -----GGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSA 241 Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757 G+ LY+I TTG EG F+ + +G P C P + L+K L+ P Sbjct: 242 GVTLYNI-TTGLYPFEGDNIYKLFENIG-KGSYAIP---GDCG--PPLSDLLKGMLEYEP 294 Query: 1758 QERPTSAQV 1766 +R + Q+ Sbjct: 295 AKRFSIRQI 303 >gi|54695938|gb|AAV38341.1| serine/threonine kinase 12 [Homo sapiens] gi|51593788|gb|AAH80581.1| Aurora kinase B [Homo sapiens] gi|4759178|ref|NP_004208.1| aurora kinase B [Homo sapiens] gi|2979630|gb|AAC12709.1| aurora-related kinase 2 [Homo sapiens] gi|27805737|sp|Q96GD4|AURKB_HUMAN Serine/threonine-protein kinase 12 (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) gi|3402293|dbj|BAA32136.1| aurora and IPL1-like midbody-associated protein kinase-1 [Homo sapiens] Length = 344 Score = 66.2 bits (160), Expect = 7e-10 Identities = 54/185 (29%), Positives = 87/185 (47%), Gaps = 16/185 (8%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 L++E A +G L + LQ+ + I +AD L Y H +I+RD+KP N+LL Sbjct: 152 LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 208 Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KIAD+G + + + KT GT + PE+ G ++N++ D++ G+L Y Sbjct: 209 ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 264 Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761 ++L G E + + ++ K P V + LI + L+ NP ER Sbjct: 265 ELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSERL 316 Query: 1762 TSAQV 1766 AQV Sbjct: 317 PLAQV 321 >gi|20269390|gb|AAM17922.1| TRK-fused gene/anaplastic large cell lymphoma kinase extra long form [Homo sapiens] Length = 803 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 374 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 433 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 434 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 491 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 492 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 546 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 547 QCWQHQPEDRPNFAIILE 564 >gi|22450878|gb|AAH18128.1| Fibroblast growth factor receptor 1, isoform 2 precursor [Homo sapiens] Length = 820 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 554 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 614 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 669 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 725 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759 >gi|609342|gb|AAA58698.1| nucleophosmin-anaplastic lymphoma kinase fusion protein Length = 680 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 251 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 310 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 311 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 368 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 369 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 423 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 424 QCWQHQPEDRPNFAIILE 441 >gi|2454168|gb|AAB71619.1| anaplastic lymphoma kinase [Homo sapiens] gi|20137251|sp|Q9UM73|ALK_HUMAN ALK tyrosine kinase receptor precursor (Anaplastic lymphoma kinase) (CD246 antigen) Length = 1620 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 1191 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 1250 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 1251 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 1308 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 1309 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 1363 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 1364 QCWQHQPEDRPNFAIILE 1381 >gi|182530|gb|AAA35835.1| FGF receptor-1 precursor [Homo sapiens] Length = 820 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 554 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 614 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 669 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 725 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759 >gi|7229261|gb|AAF42734.1| TRK-fused gene-anaplastic lymphoma kinase fusion protein [Homo sapiens] Length = 701 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 272 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 331 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 332 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 389 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 390 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 444 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 445 QCWQHQPEDRPNFAIILE 462 >gi|6739535|gb|AAF27292.1| TRK-fused gene/anaplastic lymphoma kinase (Ki-1) fusion protein long form [Homo sapiens] Length = 756 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 327 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 386 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 387 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 444 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 445 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 499 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 500 QCWQHQPEDRPNFAIILE 517 >gi|6467479|gb|AAF13156.1| double stranded RNA activated protein kinase [Homo sapiens] Length = 551 Score = 66.2 bits (160), Expect = 7e-10 Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 19/188 (10%) Query: 1585 MELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643 ME KG+L++ +++ + L + L + + G+ Y+HS +I+RDLKP N+ L Sbjct: 366 MEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT 425 Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKT-SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KI D+G+ G +T S+GT + +PE + Y ++ D+Y+ GL+L Sbjct: 426 KQ-----VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILA 479 Query: 1703 DILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 ++L E KF F +L G + D + E L+++ L + P++RP Sbjct: 480 ELLHVCDTAFETSKF---FTDLR-DGIISDIXDK-------KEETLLQKLLSKXPEDRPN 528 Query: 1763 SAQVFDIL 1770 ++++ L Sbjct: 529 TSEILRTL 536 >gi|1848244|gb|AAC51104.1| anaplastic lymphoma kinase receptor Length = 1620 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 1191 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 1250 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 1251 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 1308 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 1309 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 1363 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 1364 QCWQHQPEDRPNFAIILE 1381 >gi|10441887|gb|AAG17221.1| unknown [Homo sapiens] Length = 433 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/189 (30%), Positives = 90/189 (47%), Gaps = 17/189 (8%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642 +VME G + L + H + DGL YLHS I+++D+KP N+LL T Sbjct: 127 MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTT 186 Query: 1643 LYPNAAIIAKIADYGIAQ----YCCRMGIKTSEGTPGFRAPEVARG-NVIYNQQADVYSF 1697 KI+D G+A+ + +TS+G+P F+ PE+A G + + D++S Sbjct: 187 -----GGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSA 241 Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757 G+ LY+I TTG EG F+ + +G P C P + L+K L+ P Sbjct: 242 GVTLYNI-TTGLYPFEGDNIYKLFENIG-KGSYAIP---GDCG--PPLSDLLKGMLEYEP 294 Query: 1758 QERPTSAQV 1766 +R + Q+ Sbjct: 295 AKRFSIRQI 303 >gi|38492661|pdb|1OL7|A Chain A, Structure Of Human Aurora-A 122-403 Phosphorylated On Thr287, Thr288 gi|38492658|pdb|1OL5|A Chain A, Structure Of Aurora-A 122-403, Phosphorylated On Thr287, Thr288 And Bound To Tpx2 1-43 Length = 282 Score = 66.2 bits (160), Expect = 7e-10 Identities = 55/190 (28%), Positives = 94/190 (49%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 87 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 142 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIAD+G + + GT + PE+ G +++++ D++S G+ Sbjct: 143 L-----GSAGELKIADFGWSVHAPSSRRXXLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 196 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 197 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 248 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 249 QRPMLREVLE 258 >gi|38492660|pdb|1OL6|A Chain A, Structure Of Unphosphorylated D274n Mutant Of Aurora-A Length = 282 Score = 66.2 bits (160), Expect = 7e-10 Identities = 55/190 (28%), Positives = 95/190 (50%), Gaps = 22/190 (11%) Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A G++ R LQ+ L++ + R A ++ A+ L Y HS +I+RD+KP N+L Sbjct: 87 LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 142 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L +A KIA++G + + T GT + PE+ G +++++ D++S G+ Sbjct: 143 L-----GSAGELKIANFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 196 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y+ L G E + + + ++ PD V E LI + LK NP Sbjct: 197 LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 248 Query: 1759 ERPTSAQVFD 1768 +RP +V + Sbjct: 249 QRPMLREVLE 258 >gi|6137569|pdb|2FGI|B Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of Fgf Receptor 1 In Complex With Inhibitor Pd173074 gi|6137568|pdb|2FGI|A Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of Fgf Receptor 1 In Complex With Inhibitor Pd173074 gi|2392335|pdb|1FGK|B Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of Fibroblast Growth Factor Receptor 1 gi|2392334|pdb|1FGK|A Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of Fibroblast Growth Factor Receptor 1 gi|3114386|pdb|1FGI|B Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of Fibroblast Growth Factor Receptor 1 In Complex With Su5402 Inhibitor gi|3114385|pdb|1FGI|A Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of Fibroblast Growth Factor Receptor 1 In Complex With Su5402 Inhibitor gi|3114535|pdb|1AGW|B Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of Fibroblast Growth Factor Receptor 1 In Complex With Su4984 Inhibitor gi|3114534|pdb|1AGW|A Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of Fibroblast Growth Factor Receptor 1 In Complex With Su4984 Inhibitor Length = 310 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 101 PLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 160 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 161 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 215 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 216 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 271 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 272 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 306 >gi|1483131|dbj|BAA08343.1| p80 protein [Homo sapiens] Length = 680 Score = 66.2 bits (160), Expect = 7e-10 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%) Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633 PR +++EL + G L L++ + +SL +A +A G +YL I+RD+ Sbjct: 251 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 310 Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690 N LL P +AKI D+G+A+ R G P P A I+ Sbjct: 311 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 368 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 + D +SFG+LL++I + G + K E E G DP K P P V +++ Sbjct: 369 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 423 Query: 1751 QCLKENPQERPTSAQVFD 1768 QC + P++RP A + + Sbjct: 424 QCWQHQPEDRPNFAIILE 441 >gi|7243272|dbj|BAA92675.1| KIAA1437 protein [Homo sapiens] Length = 811 Score = 66.2 bits (160), Expect = 7e-10 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%) Query: 758 KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814 ++L L + P ++ + + L ++ N + +V+D + LK L Sbjct: 494 ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 553 Query: 815 YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865 N LS +P+ +TDV L++L + EG K+ + + L EL+++ I Sbjct: 554 SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 612 Query: 866 --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905 L +N L+ ++ SF N +A +P ++T L+ L++ Sbjct: 613 SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 672 Query: 906 NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965 NK IP + LR LD+S N++ +LP NL+ L + N+I L + + Sbjct: 673 NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 729 Query: 966 LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013 ++ LHL +N L+ +P +G L NLT +++ N L P E+G+ Sbjct: 730 QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 776 Score = 59.7 bits (143), Expect = 6e-08 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%) Query: 748 LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807 L + LT + L+LH + P + + L+V + ++ P V + P++ T Sbjct: 414 LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 470 Query: 808 -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843 LK+ L + L+F+ ENL TD+ E LE+L L GN + Sbjct: 471 GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 530 Query: 844 G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889 + LR LK LK+L L K+++S L + + ++ S +N L Sbjct: 531 ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 589 Query: 890 AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946 M ++T L+L + IP +I +L +L+ +D+ N+ I+ + H L Sbjct: 590 KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 645 Query: 947 ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987 +L ++H QI L E+ YL +++EK L LSHN L +P +I Sbjct: 646 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 705 Query: 988 GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022 G L+NL +L ++ N + + P E+ + K+ L L Sbjct: 706 GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 739 >gi|183879|gb|AAA35958.1| heparin-binding growth factor receptor Length = 822 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 556 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 615 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 616 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 671 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 726 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 727 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 761 >gi|558584|emb|CAA68679.1| tyrosine kinase [Homo sapiens] Length = 622 Score = 66.2 bits (160), Expect = 7e-10 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%) Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624 P +++E ASKG+L LQ + L+ A VA G+ YL Sbjct: 356 PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 415 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 416 SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 470 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + IY Q+DV+SFG+LL++I T GG G+ F L+ +G D K C Sbjct: 471 -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 526 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779 + +++ C P +RPT Q+ + L+ +V LT Sbjct: 527 --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 561 >gi|107565|pir||S24066 protein-tyrosine kinase (EC 2.7.1.112), receptor type tie precursor - human Length = 1138 Score = 65.9 bits (159), Expect = 9e-10 Identities = 47/157 (29%), Positives = 83/157 (52%), Gaps = 12/157 (7%) Query: 1611 RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS 1670 R A A+G++YL I+RDL NVL+ + +KIAD+G+++ + +K + Sbjct: 958 RFASDAANGMQYLSEKQFIHRDLAARNVLV-----GENLASKIADFGLSRGE-EVYVKKT 1011 Query: 1671 EGTPGFRAPEVARGNV-IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGK 1729 G R + N +Y ++DV+SFG+LL++I++ GG G+ +++L + Sbjct: 1012 MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQADR 1071 Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQV 1766 + P C V +L++QC ++ P ERP AQ+ Sbjct: 1072 MEQP---RNCD--DEVYELMRQCWRDRPYERPPFAQI 1103 >gi|7662320|ref|NP_055628.1| leucine-rich repeats and immunoglobulin-like domains 2 [Homo sapiens] gi|55664387|emb|CAH73254.1| leucine-rich repeats and immunoglobulin-like domains 2 [Homo sapiens] gi|54036167|sp|O94898|LIG2_HUMAN Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2) Length = 1065 Score = 65.9 bits (159), Expect = 9e-10 Identities = 91/366 (24%), Positives = 150/366 (40%), Gaps = 92/366 (25%) Query: 784 ANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVP------ENLT----------- 826 A LD S N + + +++ TL++ ++YN+L+ +P N+T Sbjct: 78 AILDFSHNRLSNWNI---SLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPE 134 Query: 827 ------DVVEKLEQLILEGNKISGI-CSPLRLKELKILNLSKNHISSLSENFLEACPKVE 879 LE L L N IS I S +LK LNLS N I++L + Sbjct: 135 INAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDN----- 189 Query: 880 SFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPH------------------- 920 L S+ ++KL++N+ S IP I LPH Sbjct: 190 --------------LSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTF 235 Query: 921 -----LRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS--RVEKL 973 LRSL M N I L A + N+ EL HN ++ ++ K +L+ +++L Sbjct: 236 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN---KGWLYGLRMLQQL 292 Query: 974 HLSHNKLKEIPPEI-GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFK 1032 ++S N ++ I P+ + L+ LD+SYN R + LS + L L + + Sbjct: 293 YVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVT---- 348 Query: 1033 HIGCKAKDIIRFLQQRLKKAVPYNRMKLMI--VGNTGSGKTTLLQQLMK-------TKKS 1083 HI A + RFL + N + I +G T+L + +++ TKK+ Sbjct: 349 HI---ADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKA 405 Query: 1084 DLGMQS 1089 +G++S Sbjct: 406 FIGLES 411 >gi|40788371|dbj|BAA34526.2| KIAA0806 protein [Homo sapiens] Length = 1073 Score = 65.9 bits (159), Expect = 9e-10 Identities = 91/366 (24%), Positives = 150/366 (40%), Gaps = 92/366 (25%) Query: 784 ANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVP------ENLT----------- 826 A LD S N + + +++ TL++ ++YN+L+ +P N+T Sbjct: 86 AILDFSHNRLSNWNI---SLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPE 142 Query: 827 ------DVVEKLEQLILEGNKISGI-CSPLRLKELKILNLSKNHISSLSENFLEACPKVE 879 LE L L N IS I S +LK LNLS N I++L + Sbjct: 143 INAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDN----- 197 Query: 880 SFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPH------------------- 920 L S+ ++KL++N+ S IP I LPH Sbjct: 198 --------------LSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTF 243 Query: 921 -----LRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS--RVEKL 973 LRSL M N I L A + N+ EL HN ++ ++ K +L+ +++L Sbjct: 244 QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN---KGWLYGLRMLQQL 300 Query: 974 HLSHNKLKEIPPEI-GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFK 1032 ++S N ++ I P+ + L+ LD+SYN R + LS + L L + + Sbjct: 301 YVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVT---- 356 Query: 1033 HIGCKAKDIIRFLQQRLKKAVPYNRMKLMI--VGNTGSGKTTLLQQLMK-------TKKS 1083 HI A + RFL + N + I +G T+L + +++ TKK+ Sbjct: 357 HI---ADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKA 413 Query: 1084 DLGMQS 1089 +G++S Sbjct: 414 FIGLES 419 >gi|15131540|emb|CAC48387.1| serine/threonine protein kinase [Homo sapiens] Length = 1231 Score = 65.5 bits (158), Expect = 1e-09 Identities = 58/196 (29%), Positives = 95/196 (48%), Gaps = 39/196 (19%) Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVL 1639 +LV EL + G+L L++ + R LQ R + + GL +LHS + I++RDLK NV Sbjct: 239 VLVTELMTSGTLKTYLRRFREMKPRVLQ-RWSRQILRGLHFLHSRVPPILHRDLKCDNV- 296 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 F P ++ KI D G+A K+ GTP F APE+ Y++ DVY+FG+ Sbjct: 297 -FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEK--YDEAVDVYAFGM 351 Query: 1700 LLYDILTTG-------------GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746 + ++ T+ ++ G K PN F +++I P V+ Sbjct: 352 CMLEMATSEYPYSECQNAAQIYRKVTSGRK-PNSFHKVKI----------------PEVK 394 Query: 1747 KLIKQCLKENPQERPT 1762 ++I+ C++ + ER T Sbjct: 395 EIIEGCIRTDKNERFT 410 >gi|631291|pir||S39793 MAPK-activated protein kinase 2 (EC 2.7.1.-) - human (fragment) gi|407075|emb|CAA53094.1| MAP kinase activated protein kinase-2 [Homo sapiens] Length = 396 Score = 65.5 bits (158), Expect = 1e-09 Identities = 59/201 (29%), Positives = 90/201 (44%), Gaps = 20/201 (9%) Query: 1572 EFLLAGIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIY 1630 E L AG + ++VME G L R+ + + T I + + ++YLHS I + Sbjct: 121 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 180 Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIA-QYCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689 RD+KP N+L + PNA I K+ D+G A + + T TP + APEV G Y+ Sbjct: 181 RDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYD 237 Query: 1690 QQADVYSFGLLLYDIL--------TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741 + D+ G+++Y +L G I G+K + E V E Sbjct: 238 KSCDMLVLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE----- 292 Query: 1742 WPMVEKLIKQCLKENPQERPT 1762 V+ LI+ LK P +R T Sbjct: 293 --EVKMLIRNLLKTEPTQRMT 311 >gi|182565|gb|AAA58470.1| growth factor receptor Length = 731 Score = 65.5 bits (158), Expect = 1e-09 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + LT A VA G+ YL Sbjct: 475 PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 534 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 535 SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 589 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L+ ++ P C Sbjct: 590 -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 645 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783 + ++++C P +RPT Q+ + L+ V T L Sbjct: 646 --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 686 >gi|53689008|gb|AAU89726.1| fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) [Homo sapiens] gi|4503711|ref|NP_000133.1| fibroblast growth factor receptor 3 isoform 1 precursor [Homo sapiens] gi|476557|pir||TVHUF3 fibroblast growth factor receptor 3 precursor - human gi|120050|sp|P22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 precursor (FGFR-3) gi|182569|gb|AAA52450.1| fibroblast growth factor receptor Length = 806 Score = 65.5 bits (158), Expect = 1e-09 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + LT A VA G+ YL Sbjct: 550 PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 609 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 610 SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 664 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L+ ++ P C Sbjct: 665 -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 720 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783 + ++++C P +RPT Q+ + L+ V T L Sbjct: 721 --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 761 >gi|2306915|gb|AAB65786.1| protein kinase [Homo sapiens] Length = 347 Score = 65.5 bits (158), Expect = 1e-09 Identities = 56/188 (29%), Positives = 90/188 (47%), Gaps = 19/188 (10%) Query: 1583 LVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVL 1639 L++E A +G L + L + T T++ RI +AD L Y H +I+RD+KP N+L Sbjct: 152 LILEYAPRGMLYKELHKTCTFDEQRTATVR-RIMEELADALMYCHGKKVIHRDIKPENLL 210 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 L KIAD+G + + + KT GT + PE+ G ++N++ D++ G+ Sbjct: 211 L-----GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGV 264 Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758 L Y++L G E + + ++ K P V + LI + L+ NP Sbjct: 265 LCYELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPS 316 Query: 1759 ERPTSAQV 1766 ER AQV Sbjct: 317 ERLPLAQV 324 >gi|20452381|gb|AAM22079.1| fibroblast growth factor receptor 3 [Homo sapiens] Length = 771 Score = 65.5 bits (158), Expect = 1e-09 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + LT A VA G+ YL Sbjct: 515 PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 574 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 575 SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 629 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L+ ++ P C Sbjct: 630 -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 685 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783 + ++++C P +RPT Q+ + L+ V T L Sbjct: 686 --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 726 >gi|20452380|gb|AAM22078.1| fibroblast growth factor receptor 3 [Homo sapiens] Length = 769 Score = 65.5 bits (158), Expect = 1e-09 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + LT A VA G+ YL Sbjct: 513 PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 572 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 573 SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 627 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L+ ++ P C Sbjct: 628 -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 683 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783 + ++++C P +RPT Q+ + L+ V T L Sbjct: 684 --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 724 >gi|21619202|gb|AAH32726.1| Doublecortin and CaM kinase-like 2 [Homo sapiens] gi|22749267|ref|NP_689832.1| doublecortin and CaM kinase-like 2 [Homo sapiens] Length = 695 Score = 65.5 bits (158), Expect = 1e-09 Identities = 60/193 (31%), Positives = 91/193 (47%), Gaps = 23/193 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVMEL G L D + K T + ++A+ LRYLH I++RD+KP N LL Sbjct: 466 LVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPEN-LLV 522 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 YP+ K+ D+G+A + T GTP + APE+ Y + D+++ G++ Sbjct: 523 CEYPDGTKSLKLGDFGLAT-VVEGPLYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVIT 580 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPV----KEYGCAPWPMV----EKLIKQCL 1753 Y IL G FP E +Q L D + E+ W + ++LI Q L Sbjct: 581 Y-ILLCG--------FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 631 Query: 1754 KENPQERPTSAQV 1766 + N + R T+ Q+ Sbjct: 632 QVNVEARCTAGQI 644 >gi|34365793|ref|NP_115763.2| WNK lysine deficient protein kinase 4 [Homo sapiens] gi|15212448|gb|AAK91995.1| putative protein kinase WNK4 [Homo sapiens] gi|41688789|sp|Q96J92|WNK4_HUMAN Serine/threonine-protein kinase WNK4 (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1243 Score = 65.5 bits (158), Expect = 1e-09 Identities = 58/196 (29%), Positives = 95/196 (48%), Gaps = 39/196 (19%) Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVL 1639 +LV EL + G+L L++ + R LQ R + + GL +LHS + I++RDLK NV Sbjct: 251 VLVTELMTSGTLKTYLRRFREMKPRVLQ-RWSRQILRGLHFLHSRVPPILHRDLKCDNV- 308 Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699 F P ++ KI D G+A K+ GTP F APE+ Y++ DVY+FG+ Sbjct: 309 -FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEK--YDEAVDVYAFGM 363 Query: 1700 LLYDILTTG-------------GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746 + ++ T+ ++ G K PN F +++I P V+ Sbjct: 364 CMLEMATSEYPYSECQNAAQIYRKVTSGRK-PNSFHKVKI----------------PEVK 406 Query: 1747 KLIKQCLKENPQERPT 1762 ++I+ C++ + ER T Sbjct: 407 EIIEGCIRTDKNERFT 422 >gi|13112048|ref|NP_075254.1| fibroblast growth factor receptor 3 isoform 2 precursor [Homo sapiens] gi|7533125|gb|AAF63380.1| fibroblast growth factor receptor 3 [Homo sapiens] Length = 694 Score = 65.5 bits (158), Expect = 1e-09 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%) Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624 P +++E A+KG+L L+ + LT A VA G+ YL Sbjct: 438 PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 497 Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680 S I+RDL NVL+ + KIAD+G+A+ + KT+ G + APE Sbjct: 498 SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 552 Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740 A + +Y Q+DV+SFG+LL++I T GG G+ F L+ ++ P C Sbjct: 553 -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 608 Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783 + ++++C P +RPT Q+ + L+ V T L Sbjct: 609 --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 649 >gi|4104411|gb|AAD02030.1| Eph-like receptor tyrosine kinase hEphB1 [Homo sapiens] Length = 984 Score = 65.5 bits (158), Expect = 1e-09 Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 32/266 (12%) Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 RP M++ E G+LD L+Q+ T + +A G++YL ++RDL N+ Sbjct: 691 RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 750 Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688 L+ N+ ++ K++D+G+++Y + TS+ T + APE A + Sbjct: 751 LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPE-AIAYRKF 801 Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748 +DV+S+G+ +++++ G R + + + +E +LP P C + +L Sbjct: 802 TSASDVWSYGIHMWEVMYFGERPYWDMSNQDVINAIEQDYRLPPPT---DCP--AALHQL 856 Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803 + C +++ RP A++ + L N A L + +P +++ + Sbjct: 857 MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 916 Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829 WL + + SFL T G+TS Sbjct: 917 DDWLSAIKMVQYRDSFL---TAGFTS 939 >gi|4090841|gb|AAC98891.1| serine/threonine kinase [Homo sapiens] Length = 347 Score = 65.5 bits (158), Expect = 1e-09 Identities = 56/187 (29%), Positives = 89/187 (47%), Gaps = 17/187 (9%) Query: 1583 LVMELASKGSLDRLLQQDKA-SLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLL 1640 L++E A +G L + LQ+ RT R + +AD L Y H +I+RD+KP N+LL Sbjct: 152 LILEYAPRGMLYKELQKSCTFDEQRTATVRAVMEELADALMYCHGKKVIHRDIKPENLLL 211 Query: 1641 FTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700 KIAD+G + + + KT GT + PE+ G ++N++ D++ G+L Sbjct: 212 -----GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVL 265 Query: 1701 LYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759 Y++L G E + + ++ K P V + LI + L+ NP E Sbjct: 266 CYELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSE 317 Query: 1760 RPTSAQV 1766 R AQV Sbjct: 318 RLPLAQV 324 >gi|2739208|gb|AAB94627.1| Eph-like receptor tyrosine kinase hEphB1c [Homo sapiens] Length = 943 Score = 65.5 bits (158), Expect = 1e-09 Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 32/266 (12%) Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638 RP M++ E G+LD L+Q+ T + +A G++YL ++RDL N+ Sbjct: 650 RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 709 Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688 L+ N+ ++ K++D+G+++Y + TS+ T + APE A + Sbjct: 710 LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPE-AIAYRKF 760 Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748 +DV+S+G+ +++++ G R + + + +E +LP P C + +L Sbjct: 761 TSASDVWSYGIHMWEVMYFGERPYWDMSNQDVINAIEQDYRLPPPT---DCP--AALHQL 815 Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803 + C +++ RP A++ + L N A L + +P +++ + Sbjct: 816 MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 875 Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829 WL + + SFL T G+TS Sbjct: 876 DDWLSAIKMVQYRDSFL---TAGFTS 898 >gi|21740293|emb|CAD39156.1| hypothetical protein [Homo sapiens] Length = 716 Score = 65.5 bits (158), Expect = 1e-09 Identities = 60/193 (31%), Positives = 91/193 (47%), Gaps = 23/193 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVMEL G L D + K T + ++A+ LRYLH I++RD+KP N LL Sbjct: 417 LVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPEN-LLV 473 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 YP+ K+ D+G+A + T GTP + APE+ Y + D+++ G++ Sbjct: 474 CEYPDGTKSLKLGDFGLAT-VVEGPLYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVIT 531 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPV----KEYGCAPWPMV----EKLIKQCL 1753 Y IL G FP E +Q L D + E+ W + ++LI Q L Sbjct: 532 Y-ILLCG--------FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 582 Query: 1754 KENPQERPTSAQV 1766 + N + R T+ Q+ Sbjct: 583 QVNVEARCTAGQI 595 >gi|59797954|sp|Q8N568|DCAK2_HUMAN Serine/threonine-protein kinase DCAMKL2 (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 65.5 bits (158), Expect = 1e-09 Identities = 60/193 (31%), Positives = 91/193 (47%), Gaps = 23/193 (11%) Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641 LVMEL G L D + K T + ++A+ LRYLH I++RD+KP N LL Sbjct: 467 LVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPEN-LLV 523 Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701 YP+ K+ D+G+A + T GTP + APE+ Y + D+++ G++ Sbjct: 524 CEYPDGTKSLKLGDFGLAT-VVEGPLYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVIT 581 Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPV----KEYGCAPWPMV----EKLIKQCL 1753 Y IL G FP E +Q L D + E+ W + ++LI Q L Sbjct: 582 Y-ILLCG--------FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 632 Query: 1754 KENPQERPTSAQV 1766 + N + R T+ Q+ Sbjct: 633 QVNVEARCTAGQI 645 >gi|56204147|emb|CAI22320.1| lymphocyte-specific protein tyrosine kinase [Homo sapiens] gi|6984209|gb|AAF34794.1| tyrosine kinase LCK [Homo sapiens] Length = 496 Score = 65.1 bits (157), Expect = 2e-09 Identities = 66/237 (27%), Positives = 106/237 (44%), Gaps = 33/237 (13%) Query: 1545 IAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLLQQDKAS 1603 ++PD LA+ L + L + + P ++ E GSL D L Sbjct: 267 MSPDAFLAEANLMKQLQHQRL----VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIK 322 Query: 1604 LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIA---- 1659 LT +A +A+G+ ++ I+RDL+ N+L+ + + KIAD+G+A Sbjct: 323 LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-----SDTLSCKIADFGLARLIE 377 Query: 1660 --QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKF 1717 +Y R G K + APE + ++DV+SFG+LL +I+T G G+ Sbjct: 378 DNEYTAREGAKFPIK---WTAPEAINYGT-FTIKSDVWSFGILLTEIVTHGRIPYPGMTN 433 Query: 1718 PNEFDELEIQGKL--PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS 1772 P LE ++ PD E + +L++ C KE P++RPT FD L S Sbjct: 434 PEVIQNLERGYRMVRPDNCPE-------ELYQLMRLCWKERPEDRPT----FDYLRS 479 >gi|66786|pir||OKHULK protein-tyrosine kinase (EC 2.7.1.112) lck - human gi|28317393|tpe|CAD55807.1| TPA: protein tyrosine kinase [Homo sapiens] gi|125474|sp|P06239|LCK_HUMAN Proto-oncogene tyrosine-protein kinase LCK (P56-LCK) (LSK) (T cell-specific protein-tyrosine kinase) gi|825687|emb|CAA32211.1| unnamed protein product [Homo sapiens] Length = 509 Score = 65.1 bits (157), Expect = 2e-09 Identities = 66/237 (27%), Positives = 106/237 (44%), Gaps = 33/237 (13%) Query: 1545 IAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLLQQDKAS 1603 ++PD LA+ L + L + + P ++ E GSL D L Sbjct: 280 MSPDAFLAEANLMKQLQHQRL----VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIK 335 Query: 1604 LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIA---- 1659 LT +A +A+G+ ++ I+RDL+ N+L+ + + KIAD+G+A Sbjct: 336 LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-----SDTLSCKIADFGLARLIE 390 Query: 1660 --QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKF 1717 +Y R G K + APE + ++DV+SFG+LL +I+T G G+ Sbjct: 391 DNEYTAREGAKFPIK---WTAPEAINYGT-FTIKSDVWSFGILLTEIVTHGRIPYPGMTN 446 Query: 1718 PNEFDELEIQGKL--PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS 1772 P LE ++ PD E + +L++ C KE P++RPT FD L S Sbjct: 447 PEVIQNLERGYRMVRPDNCPE-------ELYQLMRLCWKERPEDRPT----FDYLRS 492 >gi|49457414|emb|CAG47006.1| STK17B [Homo sapiens] Length = 372 Score = 65.1 bits (157), Expect = 2e-09 Identities = 51/186 (27%), Positives = 92/186 (49%), Gaps = 12/186 (6%) Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLL 1640 +L++E A+ G + L + A + R+ + +G+ YLH I++ DLKP N+LL Sbjct: 107 ILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILL 166 Query: 1641 FTLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697 ++YP I KI D+G+++ + C ++ GTP + APE+ + I D+++ Sbjct: 167 SSIYPLGDI--KIVDFGMSRKIGHACE--LREIMGTPEYLAPEILNYDPI-TTATDMWNI 221 Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757 G++ Y +LT V N+ L I D +E + + I+ L +NP Sbjct: 222 GIIAYMLLTHTSPFVGE---DNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNP 278 Query: 1758 QERPTS 1763 ++ PT+ Sbjct: 279 EKGPTA 284 >gi|50960723|gb|AAH75001.1| V-yes-1 Yamaguchi sarcoma viral related oncogene homolog [Homo sapiens] gi|50960484|gb|AAH75002.1| V-yes-1 Yamaguchi sarcoma viral related oncogene homolog [Homo sapiens] gi|4505055|ref|NP_002341.1| v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [Homo sapiens] gi|66782|pir||TVHULY protein-tyrosine kinase (EC 2.7.1.112) lyn, splice form A - human gi|125480|sp|P07948|LYN_HUMAN Tyrosine-protein kinase Lyn gi|307144|gb|AAA59540.1| lyn tyrosine kinase Length = 512 Score = 65.1 bits (157), Expect = 2e-09 Identities = 60/202 (29%), Positives = 97/202 (48%), Gaps = 29/202 (14%) Query: 1580 PRMLVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D K L + + + +A+G+ Y+ I+RDL+ Sbjct: 314 PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID--FSAQIAEGMAYIERKNYIHRDLRAA 371 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 NVL+ + +++ KIAD+G+A +Y R G K + APE + Sbjct: 372 NVLV-----SESLMCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGC-FTI 422 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LLY+I+T G G + L ++P + C + ++K Sbjct: 423 KSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP---RVENCPD--ELYDIMK 477 Query: 1751 QCLKENPQERPTSAQVFDILNS 1772 C KE +ERPT FD L S Sbjct: 478 MCWKEKAEERPT----FDYLQS 495 >gi|187271|gb|AAB50019.1| Lyn B protein [Homo sapiens] gi|741028|prf||2006286C protein Tyr kinase LYN Length = 491 Score = 65.1 bits (157), Expect = 2e-09 Identities = 60/202 (29%), Positives = 97/202 (48%), Gaps = 29/202 (14%) Query: 1580 PRMLVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D K L + + + +A+G+ Y+ I+RDL+ Sbjct: 293 PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID--FSAQIAEGMAYIERKNYIHRDLRAA 350 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 NVL+ + +++ KIAD+G+A +Y R G K + APE + Sbjct: 351 NVLV-----SESLMCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGC-FTI 401 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LLY+I+T G G + L ++P + C + ++K Sbjct: 402 KSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP---RVENCPD--ELYDIMK 456 Query: 1751 QCLKENPQERPTSAQVFDILNS 1772 C KE +ERPT FD L S Sbjct: 457 MCWKEKAEERPT----FDYLQS 474 >gi|28372413|gb|AAO38055.1| protein kinase, interferon-inducible double stranded RNA dependent [Homo sapiens] gi|4506103|ref|NP_002750.1| eukaryotic translation initiation factor 2-alpha kinase 2 [Homo sapiens] gi|2136014|pir||JC5225 dsRNA-activated protein kinase (EC 2.7.1.-) - human gi|1537049|gb|AAC50768.1| interferon-inducible RNA-dependent protein kinase [Homo sapiens] gi|125527|sp|P19525|E2AK2_HUMAN Interferon-induced, double-stranded RNA-activated protein kinase (Interferon-inducible RNA-dependent protein kinase) (p68 kinase) (P1/eIF-2A protein kinase) gi|189506|gb|AAA36409.1| p68 kinase gi|189782|gb|AAA18253.1| P1/eIF-2a protein kinase Length = 551 Score = 65.1 bits (157), Expect = 2e-09 Identities = 50/188 (26%), Positives = 93/188 (49%), Gaps = 19/188 (10%) Query: 1585 MELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643 ME KG+L++ +++ + L + L + + G+ Y+HS +I+RDLKP N+ L Sbjct: 366 MEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT 425 Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKT-SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KI D+G+ G +T S+GT + +PE + Y ++ D+Y+ GL+L Sbjct: 426 KQ-----VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILA 479 Query: 1703 DILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 ++L E KF F +L G + D + + L+++ L + P++RP Sbjct: 480 ELLHVCDTAFETSKF---FTDLR-DGIISDIFDK-------KEKTLLQKLLSKKPEDRPN 528 Query: 1763 SAQVFDIL 1770 ++++ L Sbjct: 529 TSEILRTL 536 >gi|37589566|gb|AAH59394.1| LYN protein [Homo sapiens] gi|46250025|gb|AAH68551.1| LYN protein [Homo sapiens] Length = 582 Score = 65.1 bits (157), Expect = 2e-09 Identities = 60/202 (29%), Positives = 97/202 (48%), Gaps = 29/202 (14%) Query: 1580 PRMLVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636 P ++ E +KGSL L+ D K L + + + +A+G+ Y+ I+RDL+ Sbjct: 384 PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID--FSAQIAEGMAYIERKNYIHRDLRAA 441 Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690 NVL+ + +++ KIAD+G+A +Y R G K + APE + Sbjct: 442 NVLV-----SESLMCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGC-FTI 492 Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750 ++DV+SFG+LLY+I+T G G + L ++P + C + ++K Sbjct: 493 KSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP---RVENCPD--ELYDIMK 547 Query: 1751 QCLKENPQERPTSAQVFDILNS 1772 C KE +ERPT FD L S Sbjct: 548 MCWKEKAEERPT----FDYLQS 565 >gi|31747519|gb|AAP57628.1| interferon-inducible double-stranded RNA-dependent protein kinase [Homo sapiens] Length = 510 Score = 65.1 bits (157), Expect = 2e-09 Identities = 50/188 (26%), Positives = 93/188 (49%), Gaps = 19/188 (10%) Query: 1585 MELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643 ME KG+L++ +++ + L + L + + G+ Y+HS +I+RDLKP N+ L Sbjct: 325 MEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT 384 Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKT-SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702 KI D+G+ G +T S+GT + +PE + Y ++ D+Y+ GL+L Sbjct: 385 KQ-----VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILA 438 Query: 1703 DILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762 ++L E KF F +L G + D + + L+++ L + P++RP Sbjct: 439 ELLHVCDTAFETSKF---FTDLR-DGIISDIFDK-------KEKTLLQKLLSKKPEDRPN 487 Query: 1763 SAQVFDIL 1770 ++++ L Sbjct: 488 TSEILRTL 495 >gi|5139790|dbj|BAA81737.1| atrial natriuretic peptide Btype receptor [Homo sapiens] Length = 1047 Score = 65.1 bits (157), Expect = 2e-09 Identities = 60/216 (27%), Positives = 105/216 (48%), Gaps = 19/216 (8%) Query: 1564 ELEFEQAPEFLLAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLR 1621 +++F F+ A I P +V E +GSL +L+ D +L ++ + + G+ Sbjct: 573 DVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMA 632 Query: 1622 YLHSAMI-IYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPG---FR 1677 +LH+++I + LK N ++ ++ + KI DYG+A + S + Sbjct: 633 FLHNSIISSHGSLKSSNCVV-----DSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWT 687 Query: 1678 APEVARGNVIYN---QQADVYSFGLLLYDI-LTTGGRIVEGLKF-PNEFDELEIQGKLP- 1731 APE+ GN + Q+ADVYSFG++L +I L +G +EGL P E + G+ P Sbjct: 688 APELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPY 747 Query: 1732 -DPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQV 1766 P + +V L+++C ++P ERP Q+ Sbjct: 748 FRPSIDRSQLNEELV-LLMERCWAQDPAERPDFGQI 782 >gi|20428652|ref|NP_005347.2| lymphocyte-specific protein tyrosine kinase [Homo sapiens] gi|34295|emb|CAA31884.1| unnamed protein product [Homo sapiens] Length = 509 Score = 65.1 bits (157), Expect = 2e-09 Identities = 66/237 (27%), Positives = 106/237 (44%), Gaps = 33/237 (13%) Query: 1545 IAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLLQQDKAS 1603 ++PD LA+ L + L + + P ++ E GSL D L Sbjct: 280 MSPDAFLAEANLMKQLQHQRL----VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIK 335 Query: 1604 LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIA---- 1659 LT +A +A+G+ ++ I+RDL+ N+L+ + + KIAD+G+A Sbjct: 336 LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-----SDTLSCKIADFGLARLIE 390 Query: 1660 --QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKF 1717 +Y R G K + APE + ++DV+SFG+LL +I+T G G+ Sbjct: 391 DNEYTAREGAKFPIK---WTAPEAINYGT-FTIKSDVWSFGILLTEIVTHGRIPYPGMTN 446 Query: 1718 PNEFDELEIQGKL--PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS 1772 P LE ++ PD E + +L++ C KE P++RPT FD L S Sbjct: 447 PEVIQNLERGYRMVRPDNCPE-------ELYQLMRLCWKERPEDRPT----FDYLRS 492 Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF excluding environmental samples Posted date: Mar 15, 2005 10:11 AM Number of letters in database: 802,797,248 Number of sequences in database: 2,367,365 Lambda K H 0.321 0.136 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,565,578 Number of Sequences: 2367365 Number of extensions: 1145734 Number of successful extensions: 3669 Number of sequences better than 10.0: 440 Number of HSP's better than 10.0 without gapping: 146 Number of HSP's successfully gapped in prelim test: 294 Number of HSP's that attempted gapping in prelim test: 2834 Number of HSP's gapped (non-prelim): 685 length of query: 2111 length of database: 46,038,991 effective HSP length: 123 effective length of query: 1988 effective length of database: 30,031,648 effective search space: 59702916224 effective search space used: 59702916224 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 73 (32.7 bits)