BLASTP 2.2.10 [Oct-19-2004]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

RID: 1111138257-18955-112106929505.BLASTQ4

Query= ENr123_FGENESH_gen3 43 exon (s) 278725  - 421358  2111
aa, chain +
         (2111 letters)


Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples 
           2,367,365 sequences; 802,797,248 total letters

 
If you have any problems or questions with the results of this search 
please refer to the BLAST FAQs

Taxonomy reports

Related Structures

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55740398|gb|AAV63975.1|  leucine-rich repeat kinase 2 [Ho...  3303   0.0   
gi|41149741|ref|XP_058513.7|  PREDICTED: similar to RIKEN cD...  3303   0.0   
gi|34534766|dbj|BAC87105.1|  unnamed protein product [Homo s...  1132   0.0   
gi|21740356|emb|CAD39185.1|  hypothetical protein [Homo sapi...   631   e-180 
gi|14017797|dbj|BAB47419.1|  KIAA1790 protein [Homo sapiens]      161   1e-38 
gi|33469143|ref|NP_078928.2|  leucine-rich repeat kinase 1 [...   147   2e-34 
gi|4758704|ref|NP_004216.1|  malignant fibrous histiocytoma ...   108   9e-23 
gi|34526495|dbj|BAC85125.1|  FLJ00262 protein [Homo sapiens]      102   7e-21 
gi|31416932|gb|AAH05408.2|  LRRK1 protein [Homo sapiens]          102   7e-21 
gi|55661683|emb|CAH72812.1|  OTTHUMP00000058851 [Homo sapien...    95   2e-18 
gi|40788390|dbj|BAA74885.2|  KIAA0862 protein [Homo sapiens]       95   2e-18 
gi|55661684|emb|CAH72813.1|  soc-2 suppressor of clear homol...    94   4e-18 
gi|32812252|gb|AAP88017.1|  CRIB1 [Homo sapiens] >gi|4582772...    88   2e-16 
gi|32812254|gb|AAP88018.1|  SCRIB1 variant N1 [Homo sapiens]       88   2e-16 
gi|45827731|ref|NP_874365.2|  scribble isoform a [Homo sapiens]    88   2e-16 
gi|18032008|gb|AAL38976.1|  scribble [Homo sapiens]                88   2e-16 
gi|56205237|emb|CAI22332.1|  novel protein [Homo sapiens] >g...    86   8e-16 
gi|32425389|gb|AAH03407.2|  FLJ20331 protein [Homo sapiens]        86   8e-16 
gi|51094908|gb|EAL24153.1|  similar to hypothetical protein ...    83   5e-15 
gi|56204430|emb|CAI22426.1|  OTTHUMP00000065337 [Homo sapien...    82   1e-14 
gi|56204429|emb|CAI22425.1|  OTTHUMP00000065336 [Homo sapien...    82   1e-14 
gi|51476914|emb|CAH18423.1|  hypothetical protein [Homo sapi...    82   1e-14 
gi|29791785|gb|AAH50692.1|  ERBB2IP protein [Homo sapiens]         81   2e-14 
gi|55770895|ref|NP_001006600.1|  ERBB2 interacting protein i...    81   2e-14 
gi|8923909|ref|NP_061165.1|  ERBB2 interacting protein isofo...    81   2e-14 
gi|14582259|gb|AAK69431.1|  densin-180-like protein [Homo sa...    81   2e-14 
gi|13112035|gb|AAH03193.1|  LRRC1 protein [Homo sapiens] >gi...    80   5e-14 
gi|37221175|ref|NP_919431.1|  suprachiasmatic nucleus circad...    80   6e-14 
gi|422993|pir||JU0229  mixed-lineage protein kinase 1 - huma...    80   6e-14 
gi|34809548|gb|AAH14927.2|  PLEKHE1 protein [Homo sapiens]         80   6e-14 
gi|7023489|dbj|BAA91980.1|  unnamed protein product [Homo sa...    80   6e-14 
gi|20521103|dbj|BAA25532.2|  KIAA0606 protein [Homo sapiens]       80   6e-14 
gi|52421790|ref|NP_149132.2|  mitogen-activated protein kina...    79   1e-13 
gi|33591094|gb|AAQ23054.1|  mixed-lineage protein kinase 1 [...    79   1e-13 
gi|12005724|gb|AAG44591.1|  mixed lineage kinase MLK1 [Homo ...    79   1e-13 
gi|21450844|ref|NP_647611.1|  megakaryocyte-associated tyros...    77   3e-13 
gi|21450846|ref|NP_647612.1|  megakaryocyte-associated tyros...    77   3e-13 
gi|21450842|ref|NP_002369.2|  megakaryocyte-associated tyros...    77   3e-13 
gi|559594|gb|AAB30995.1|  leukocyte carboxyl-terminal src ki...    77   4e-13 
gi|14916455|ref|NP_149117.1|  protein serine kinase H2 [Homo...    75   1e-12 
gi|55958775|emb|CAI16469.1|  fyn-related kinase [Homo sapien...    75   1e-12 
gi|54696178|gb|AAV38461.1|  mitogen-activated protein kinase...    75   1e-12 
gi|732528|gb|AAC50116.1|  Rak                                      75   1e-12 
gi|29124496|gb|AAH48960.1|  Viral oncogene yes-1 homolog 1 [...    74   3e-12 
gi|1082750|pir||A49865  protein-tyrosine kinase (EC 2.7.1.11...    74   3e-12 
gi|2392699|pdb|2HCK|B  Chain B, Src Family Kinase Hck-Querce...    74   3e-12 
gi|7981277|emb|CAB91984.1|  protein serine kinase [Homo sapi...    74   4e-12 
gi|56204061|emb|CAI23531.1|  MAP3K7 [Homo sapiens] >gi|56203...    73   6e-12 
gi|56204060|emb|CAI23530.1|  MAP3K7 [Homo sapiens] >gi|56203...    73   6e-12 
gi|56204062|emb|CAI23532.1|  MAP3K7 [Homo sapiens] >gi|56203...    73   6e-12 
gi|56204063|emb|CAI23533.1|  MAP3K7 [Homo sapiens] >gi|56203...    73   6e-12 
gi|54696176|gb|AAV38460.1|  mitogen-activated protein kinase...    73   6e-12 
gi|4507277|ref|NP_003148.1|  NIMA (never in mitosis gene a)-...    73   6e-12 
gi|7513397|pir||JC5957  transforming growth factor-beta acti...    73   6e-12 
gi|38648684|gb|AAH63044.1|  NEK4 protein [Homo sapiens]            73   6e-12 
gi|56462535|emb|CAI16055.1|  TEK tyrosine kinase, endothelia...    73   7e-12 
gi|4557869|ref|NP_000450.1|  TEK tyrosine kinase, endothelia...    73   7e-12 
gi|15988251|pdb|1FVR|B  Chain B, Tie2 Kinase Domain >gi|1598...    73   7e-12 
gi|47524177|ref|NP_075252.2|  fibroblast growth factor recep...    72   1e-11 
gi|21595367|gb|AAH32413.1|  B lymphoid tyrosine kinase [Homo...    72   1e-11 
gi|15080148|gb|AAH11847.1|  Fibroblast growth factor recepto...    72   1e-11 
gi|476558|pir||TVHUF4  fibroblast growth factor receptor 4 p...    72   1e-11 
gi|23273968|gb|AAH35514.1|  TEK protein [Homo sapiens]             72   1e-11 
gi|20153207|gb|AAM13666.1|  fibroblast growth factor recepto...    72   1e-11 
gi|18250298|ref|NP_543013.1|  src-related kinase lacking C-t...    72   1e-11 
gi|13991618|gb|AAK51435.1|  fibroblast growth factor recepto...    72   1e-11 
gi|6739818|gb|AAF27432.1|  fibroblast growth factor receptor...    72   1e-11 
gi|2117797|pir||I37206  protein-tyrosine kinase (EC 2.7.1.11...    72   1e-11 
gi|2832350|emb|CAA74200.1|  fibroblast growth factor 4 [Homo...    72   1e-11 
gi|21735550|ref|NP_002437.2|  mitogen-activated protein kina...    72   1e-11 
gi|971420|emb|CAA62351.1|  mixed lineage kinase 2 [Homo sapi...    72   1e-11 
gi|758593|emb|CAA88531.1|  serine/threonine kinase with SH3 ...    72   1e-11 
gi|914204|gb|AAB33265.1|  protein tyrosine kinase [Homo sapi...    72   1e-11 
gi|56203175|emb|CAI22966.1|  HCK [Homo sapiens] >gi|56205100...    72   2e-11 
gi|306832|gb|AAA52643.1|  protein-tyrosine kinase                  72   2e-11 
gi|30795229|ref|NP_002101.2|  hemopoietic cell kinase isofor...    72   2e-11 
gi|56203176|emb|CAI22967.1|  HCK [Homo sapiens] >gi|56205101...    72   2e-11 
gi|10439296|dbj|BAB15482.1|  unnamed protein product [Homo s...    72   2e-11 
gi|19923729|ref|NP_115646.2|  hypothetical protein AD158 [Ho...    72   2e-11 
gi|50949358|emb|CAB66853.2|  hypothetical protein [Homo sapi...    72   2e-11 
gi|5542349|pdb|1QCF|A  Chain A, Crystal Structure Of Hck In ...    72   2e-11 
gi|5804911|emb|CAA41565.2|  tyrosine kinase [Homo sapiens]         72   2e-11 
gi|56204189|emb|CAI23046.1|  mixed lineage kinase 4 (KIAA180...    71   3e-11 
gi|4503743|ref|NP_002009.1|  flightless I homolog [Homo sapi...    71   3e-11 
gi|56204188|emb|CAI23045.1|  mixed lineage kinase 4 (KIAA180...    71   3e-11 
gi|2135121|pir||A49674  flightless-I homolog - human (fragme...    71   3e-11 
gi|5174647|ref|NP_005966.1|  PTK6 protein tyrosine kinase 6 ...    70   4e-11 
gi|37181696|gb|AAQ88655.1|  SAPS287 [Homo sapiens] >gi|40255...    70   5e-11 
gi|47458813|ref|NP_006242.4|  protein kinase, AMP-activated,...    70   5e-11 
gi|20178277|sp|Q13131|AAPK1_HUMAN  5'-AMP-activated protein ...    70   5e-11 
gi|50845418|ref|NP_065973.2|  WNK lysine deficient protein k...    70   6e-11 
gi|30016945|gb|AAP03432.1|  v-raf-1 murine leukemia viral on...    70   6e-11 
gi|4826878|ref|NP_005100.1|  oxidative-stress responsive 1 [...    70   6e-11 
gi|57284054|emb|CAI43129.1|  protein kinase, lysine deficien...    70   6e-11 
gi|57284053|emb|CAI43128.1|  protein kinase, lysine deficien...    70   6e-11 
gi|40789046|dbj|BAA83053.2|  KIAA1101 protein [Homo sapiens]       70   6e-11 
gi|19908348|gb|AAL99253.1|  putative protein kinase WNK3 [Ho...    70   6e-11 
gi|496091|gb|AAA60247.1|  RAF1                                     70   6e-11 
gi|227082|prf||1613537A  c-raf1 protooncogene                      70   6e-11 
gi|55961054|emb|CAI13543.1|  mitogen-activated protein kinas...    69   1e-10 
gi|4502557|ref|NP_001735.1|  calcium/calmodulin-dependent pr...    69   1e-10 
gi|32481209|ref|NP_116584.2|  mitogen-activated protein kina...    69   1e-10 
gi|54035072|gb|AAH16695.2|  CAMK4 protein [Homo sapiens]           69   1e-10 
gi|4758284|ref|NP_004432.1|  ephrin receptor EphB1 precursor...    69   1e-10 
gi|19263755|gb|AAH25307.1|  PRKD2 protein [Homo sapiens]           69   1e-10 
gi|22760266|dbj|BAC11127.1|  unnamed protein product [Homo s...    69   1e-10 
gi|22761242|dbj|BAC11508.1|  unnamed protein product [Homo s...    69   1e-10 
gi|7019543|ref|NP_037365.1|  serine threonine kinase 39 (STE...    69   1e-10 
gi|19923468|ref|NP_057541.2|  protein kinase D2 [Homo sapien...    69   1e-10 
gi|17736731|emb|CAC84640.1|  mixed lineage kinase 4beta [Hom...    69   1e-10 
gi|17736729|emb|CAC84639.1|  mixed lineage kinase 4alpha [Ho...    69   1e-10 
gi|27769064|gb|AAH42334.1|  Similar to RIKEN cDNA 1300018K11...    69   1e-10 
gi|4884154|emb|CAB43292.1|  hypothetical protein [Homo sapie...    69   1e-10 
gi|49457444|emb|CAG47021.1|  STK17B [Homo sapiens]                 69   1e-10 
gi|2144413|pir||TVHUBF  protein kinase B-raf (EC 2.7.1.-) - ...    68   2e-10 
gi|12314068|emb|CAC12717.1|  GD:STK6 [Homo sapiens] >gi|3832...    68   2e-10 
gi|4502553|ref|NP_003647.1|  calcium/calmodulin-dependent pr...    68   2e-10 
gi|51094777|gb|EAL24023.1|  v-raf murine sarcoma viral oncog...    68   2e-10 
gi|56792342|gb|AAW30454.1|  AKAP9-BRAF fusion protein [Homo ...    68   2e-10 
gi|12803361|gb|AAH02499.1|  STK6 protein [Homo sapiens] >gi|...    68   2e-10 
gi|19424132|ref|NP_598001.1|  NIMA (never in mitosis gene a)...    68   2e-10 
gi|11125348|emb|CAC15059.1|  putative protein kinase [Homo s...    68   2e-10 
gi|6933864|gb|AAF31483.1|  kinase deficient protein KDP [Hom...    68   2e-10 
gi|6851302|gb|AAF29508.1|  STK15 serine/threonine kinase [Ho...    68   2e-10 
gi|5441948|gb|AAD43193.1|  serine/threonine protein kinase; ...    68   2e-10 
gi|4103971|gb|AAD01901.1|  Ste20-like protein kinase [Homo s...    68   2e-10 
gi|7446411|pir||JC5974  aurora-related kinase 1 (EC 2.7.-.-)...    68   2e-10 
gi|47169341|pdb|1UWH|B  Chain B, The Complex Of Wild Type B-...    68   2e-10 
gi|37926805|pdb|1MQ4|A  Chain A, Crystal Structure Of Aurora...    68   2e-10 
gi|30749504|pdb|1MUO|A  Chain A, Crystal Structure Of Aurora...    68   2e-10 
gi|179535|gb|AAA96495.1|  B-raf protein                            68   2e-10 
gi|20521007|dbj|BAA20802.2|  KIAA0344 [Homo sapiens]               68   2e-10 
gi|14602490|gb|AAH09751.1|  Aurora kinase B [Homo sapiens]         68   2e-10 
gi|56202636|emb|CAI19991.1|  calcium/calmodulin-dependent pr...    68   2e-10 
gi|1161364|gb|AAB60412.1|  tyrosine kinase                         68   2e-10 
gi|37727961|gb|AAR02359.1|  interleukin-1 receptor-associate...    68   2e-10 
gi|1848077|emb|CAA26485.1|  c-src [Homo sapiens]                   68   2e-10 
gi|4758194|ref|NP_004217.1|  serine/threonine kinase 17b (ap...    68   2e-10 
gi|15079460|gb|AAH11566.1|  SRC protein [Homo sapiens] >gi|5...    68   2e-10 
gi|4557511|ref|NP_001339.1|  death-associated protein kinase...    68   2e-10 
gi|33870194|gb|AAH13300.2|  AURKB protein [Homo sapiens]           68   2e-10 
gi|20219010|gb|AAM15772.1|  interleukin-1 receptor associate...    68   2e-10 
gi|30271862|gb|AAP29964.1|  CLICK III [Homo sapiens]               68   2e-10 
gi|56205021|emb|CAI22921.1|  GD:SRC [Homo sapiens] >gi|10436...    68   2e-10 
gi|10635153|emb|CAC10573.1|  GD:SRC [Homo sapiens] >gi|62521...    68   2e-10 
gi|7023013|dbj|BAA91801.1|  unnamed protein product [Homo sa...    68   2e-10 
gi|4678722|emb|CAB41259.1|  hypothetical protein [Homo sapiens]    68   2e-10 
gi|37727969|gb|AAR02363.1|  interleukin-1 receptor-associate...    68   2e-10 
gi|4507743|ref|NP_003319.1|  TXK tyrosine kinase [Homo sapie...    68   2e-10 
gi|16755792|gb|AAL28100.1|  calcium/calmodulin-dependent pro...    68   2e-10 
gi|47169343|pdb|1UWJ|B  Chain B, The Complex Of Mutant V599e...    68   2e-10 
gi|56404655|sp|Q96NX5|KCC1G_HUMAN  Calcium/calmodulin-depend...    68   2e-10 
gi|5822499|pdb|2SRC|   Crystal Structure Of Human Tyrosine-P...    68   2e-10 
gi|56208156|emb|CAI22301.1|  FYN oncogene related to SRC, FG...    67   3e-10 
gi|56208155|emb|CAI22300.1|  FYN oncogene related to SRC, FG...    67   3e-10 
gi|5031689|ref|NP_005804.1|  protein kinase D3 [Homo sapiens...    67   3e-10 
gi|56208154|emb|CAI22299.1|  FYN oncogene related to SRC, FG...    67   3e-10 
gi|21618480|gb|AAH32496.1|  Protein-tyrosine kinase fyn, iso...    67   3e-10 
gi|18265389|gb|AAL67158.1|  zipper protein kinase [Homo sapi...    67   4e-10 
gi|37181368|gb|AAQ88498.1|  densin hlg [Homo sapiens] >gi|55...    67   4e-10 
gi|4506075|ref|NP_002733.1|  protein kinase D1 [Homo sapiens...    67   4e-10 
gi|29476775|gb|AAH50050.1|  MAP3K12 protein [Homo sapiens]         67   4e-10 
gi|56204512|emb|CAI23271.1|  protein kinase N2 [Homo sapiens...    67   4e-10 
gi|55665040|emb|CAH72254.1|  OTTHUMP00000012587 [Homo sapiens]     67   4e-10 
gi|2641948|dbj|BAA23592.1|  aurora/IPL1-related kinase [Homo...    67   4e-10 
gi|47458815|ref|NP_996790.2|  protein kinase, AMP-activated,...    67   4e-10 
gi|21735552|ref|NP_006292.2|  mitogen-activated protein kina...    67   4e-10 
gi|29124503|gb|AAH48980.1|  PRKAA1 protein [Homo sapiens]          67   4e-10 
gi|4104413|gb|AAD02031.1|  Eph-like receptor tyrosine kinase...    67   4e-10 
gi|2136035|pir||I38138  protein-serine kinase (EC 2.7.1.-) P...    67   4e-10 
gi|631347|pir||JC2363  protein kinase (EC 2.7.1.37) ZPK - human    67   4e-10 
gi|18202489|sp|Q12852|M3K12_HUMAN  Mitogen-activated protein...    67   4e-10 
gi|20151029|pdb|1KSW|A  Chain A, Structure Of Human C-Src Ty...    67   4e-10 
gi|1362858|pir||A56708  MAPK/ERK kinase 5 - human                  67   5e-10 
gi|56203182|emb|CAC17574.2|  protein kinase, AMP-activated, ...    67   5e-10 
gi|758367|gb|AAA64745.1|  AMP-activated protein kinase             67   5e-10 
gi|338228|gb|AAA36615.1|  src-like tyrosine kinase (put.); p...    67   5e-10 
gi|37182866|gb|AAQ89233.1|  LRRC5 [Homo sapiens]                   67   5e-10 
gi|23241685|gb|AAH34988.1|  ULK2 protein [Homo sapiens]            67   5e-10 
gi|22760350|dbj|BAC11161.1|  unnamed protein product [Homo s...    67   5e-10 
gi|55663684|emb|CAH72226.1|  leucine rich repeat containing ...    67   5e-10 
gi|7022525|dbj|BAA91631.1|  unnamed protein product [Homo sa...    67   5e-10 
gi|40788306|dbj|BAA31598.2|  KIAA0623 protein [Homo sapiens]       67   5e-10 
gi|23199985|ref|NP_055498.2|  unc-51-like kinase 2 [Homo sap...    67   5e-10 
gi|4758700|ref|NP_004626.1|  mitogen-activated protein kinas...    67   5e-10 
gi|52545731|emb|CAH56273.1|  hypothetical protein [Homo sapi...    67   5e-10 
gi|52545685|emb|CAH56285.1|  hypothetical protein [Homo sapi...    67   5e-10 
gi|9247171|gb|AAB33113.2|  tyrosine kinase p59fyn(T) [Homo s...    67   5e-10 
gi|5688866|dbj|BAA82709.1|  Aik2 [Homo sapiens]                    67   5e-10 
gi|29029632|ref|NP_004295.2|  anaplastic lymphoma kinase Ki-...    66   7e-10 
gi|14042212|dbj|BAB55153.1|  unnamed protein product [Homo s...    66   7e-10 
gi|13186236|ref|NP_075594.1|  fibroblast growth factor recep...    66   7e-10 
gi|37181692|gb|AAQ88653.1|  RQTI221 [Homo sapiens] >gi|39930...    66   7e-10 
gi|11276087|ref|NP_000595.1|  fibroblast growth factor recep...    66   7e-10 
gi|31368|emb|CAA36101.1|  unnamed protein product [Homo sapi...    66   7e-10 
gi|179415|gb|AAA75007.1|  basic fibroblast growth factor rec...    66   7e-10 
gi|13186251|ref|NP_056934.2|  fibroblast growth factor recep...    66   7e-10 
gi|182534|gb|AAA35837.1|  fibroblast growth factor receptor ...    66   7e-10 
gi|13186234|ref|NP_075593.1|  fibroblast growth factor recep...    66   7e-10 
gi|37181710|gb|AAQ88662.1|  SAPS287 [Homo sapiens]                 66   7e-10 
gi|30410930|gb|AAH51322.1|  LRRC8 protein [Homo sapiens] >gi...    66   7e-10 
gi|38197155|gb|AAH00442.2|  AURKB protein [Homo sapiens]           66   7e-10 
gi|21955340|gb|AAH15035.1|  FGFR1 protein [Homo sapiens]           66   7e-10 
gi|17939640|gb|AAH19334.1|  Serine/threonine protein kinase ...    66   7e-10 
gi|54695938|gb|AAV38341.1|  serine/threonine kinase 12 [Homo...    66   7e-10 
gi|20269390|gb|AAM17922.1|  TRK-fused gene/anaplastic large ...    66   7e-10 
gi|22450878|gb|AAH18128.1|  Fibroblast growth factor recepto...    66   7e-10 
gi|609342|gb|AAA58698.1|  nucleophosmin-anaplastic lymphoma ...    66   7e-10 
gi|2454168|gb|AAB71619.1|  anaplastic lymphoma kinase [Homo ...    66   7e-10 
gi|182530|gb|AAA35835.1|  FGF receptor-1 precursor [Homo sap...    66   7e-10 
gi|7229261|gb|AAF42734.1|  TRK-fused gene-anaplastic lymphom...    66   7e-10 
gi|6739535|gb|AAF27292.1|  TRK-fused gene/anaplastic lymphom...    66   7e-10 
gi|6467479|gb|AAF13156.1|  double stranded RNA activated pro...    66   7e-10 
gi|1848244|gb|AAC51104.1|  anaplastic lymphoma kinase receptor     66   7e-10 
gi|10441887|gb|AAG17221.1|  unknown [Homo sapiens]                 66   7e-10 
gi|38492661|pdb|1OL7|A  Chain A, Structure Of Human Aurora-A...    66   7e-10 
gi|38492660|pdb|1OL6|A  Chain A, Structure Of Unphosphorylat...    66   7e-10 
gi|6137569|pdb|2FGI|B  Chain B, Crystal Structure Of The Tyr...    66   7e-10 
gi|1483131|dbj|BAA08343.1|  p80 protein [Homo sapiens]             66   7e-10 
gi|7243272|dbj|BAA92675.1|  KIAA1437 protein [Homo sapiens]        66   7e-10 
gi|183879|gb|AAA35958.1|  heparin-binding growth factor rece...    66   7e-10 
gi|558584|emb|CAA68679.1|  tyrosine kinase [Homo sapiens]          66   7e-10 
gi|107565|pir||S24066  protein-tyrosine kinase (EC 2.7.1.112...    66   9e-10 
gi|7662320|ref|NP_055628.1|  leucine-rich repeats and immuno...    66   9e-10 
gi|40788371|dbj|BAA34526.2|  KIAA0806 protein [Homo sapiens]       66   9e-10 
gi|15131540|emb|CAC48387.1|  serine/threonine protein kinase...    65   1e-09 
gi|631291|pir||S39793  MAPK-activated protein kinase 2 (EC 2...    65   1e-09 
gi|182565|gb|AAA58470.1|  growth factor receptor                   65   1e-09 
gi|53689008|gb|AAU89726.1|  fibroblast growth factor recepto...    65   1e-09 
gi|2306915|gb|AAB65786.1|  protein kinase [Homo sapiens]           65   1e-09 
gi|20452381|gb|AAM22079.1|  fibroblast growth factor recepto...    65   1e-09 
gi|20452380|gb|AAM22078.1|  fibroblast growth factor recepto...    65   1e-09 
gi|21619202|gb|AAH32726.1|  Doublecortin and CaM kinase-like...    65   1e-09 
gi|34365793|ref|NP_115763.2|  WNK lysine deficient protein k...    65   1e-09 
gi|13112048|ref|NP_075254.1|  fibroblast growth factor recep...    65   1e-09 
gi|4104411|gb|AAD02030.1|  Eph-like receptor tyrosine kinase...    65   1e-09 
gi|4090841|gb|AAC98891.1|  serine/threonine kinase [Homo sap...    65   1e-09 
gi|2739208|gb|AAB94627.1|  Eph-like receptor tyrosine kinase...    65   1e-09 
gi|21740293|emb|CAD39156.1|  hypothetical protein [Homo sapi...    65   1e-09 
gi|59797954|sp|Q8N568|DCAK2_HUMAN  Serine/threonine-protein ...    65   1e-09 
gi|56204147|emb|CAI22320.1|  lymphocyte-specific protein tyr...    65   2e-09 
gi|66786|pir||OKHULK  protein-tyrosine kinase (EC 2.7.1.112)...    65   2e-09 
gi|49457414|emb|CAG47006.1|  STK17B [Homo sapiens]                 65   2e-09 
gi|50960723|gb|AAH75001.1|  V-yes-1 Yamaguchi sarcoma viral ...    65   2e-09 
gi|187271|gb|AAB50019.1|  Lyn B protein [Homo sapiens] >gi|7...    65   2e-09 
gi|28372413|gb|AAO38055.1|  protein kinase, interferon-induc...    65   2e-09 
gi|37589566|gb|AAH59394.1|  LYN protein [Homo sapiens] >gi|4...    65   2e-09 
gi|31747519|gb|AAP57628.1|  interferon-inducible double-stra...    65   2e-09 
gi|5139790|dbj|BAA81737.1|  atrial natriuretic peptide Btype...    65   2e-09 
gi|20428652|ref|NP_005347.2|  lymphocyte-specific protein ty...    65   2e-09 
gi|187034|gb|AAA59502.1|  lymphocyte-specific protein tyrosi...    65   2e-09 
gi|476555|pir||TVHU2F  fibroblast growth factor receptor flg...    65   2e-09 
gi|10441883|gb|AAG17219.1|  unknown [Homo sapiens]                 65   2e-09 
gi|1000127|gb|AAC50209.1|  PRK1 >gi|6174910|sp|Q16512|PKL1_H...    65   2e-09 
gi|23398605|gb|AAH38239.1|  Tyrosine kinase with immunoglobu...    65   2e-09 
gi|55859715|emb|CAI10986.1|  natriuretic peptide receptor B\...    65   2e-09 
gi|4506101|ref|NP_002748.1|  mitogen-activated protein kinas...    65   2e-09 
gi|284146|pir||A38224  protein-tyrosine kinase (EC 2.7.1.112...    65   2e-09 
gi|47132589|ref|NP_002732.3|  protein kinase N1 isoform 2 [H...    65   2e-09 
gi|13559171|emb|CAC36078.1|  C447E6.2 (insulin-like growth f...    65   2e-09 
gi|15030037|gb|AAH11263.1|  Mitogen-activated protein kinase...    65   2e-09 
gi|55859716|emb|CAI10987.1|  OTTHUMP00000045390 [Homo sapien...    65   2e-09 
gi|30039692|ref|NP_835464.1|  NIMA-related kinase 8 [Homo sa...    65   2e-09 
gi|45181421|gb|AAS55390.1|  dusty protein kinase [Homo sapie...    65   2e-09 
gi|47132591|ref|NP_998725.1|  protein kinase N1 isoform 1 [H...    65   2e-09 
gi|21729897|ref|NP_660144.1|  mitogen-activated protein kina...    65   2e-09 
gi|56204241|emb|CAI23386.1|  tyrosine kinase with immunoglob...    65   2e-09 
gi|48734889|gb|AAH72406.1|  Receptor interacting protein kin...    65   2e-09 
gi|40806179|ref|NP_056190.1|  receptor interacting protein k...    65   2e-09 
gi|25304069|gb|AAH40061.1|  Protein kinase C-like 1, isoform...    65   2e-09 
gi|40353033|gb|AAH64543.1|  Mitogen-activated protein kinase...    65   2e-09 
gi|18606407|gb|AAH23017.1|  Similar to natriuretic peptide r...    65   2e-09 
gi|19344010|gb|AAH25681.1|  Insulin-like growth factor bindi...    65   2e-09 
gi|36808|emb|CAA28691.1|  unnamed protein product [Homo sapi...    65   2e-09 
gi|1616781|gb|AAB16852.1|  MAP kinase kinase MEK5c [Homo sap...    65   2e-09 
gi|8569441|pdb|1QPD|A  Chain A, Structural Analysis Of The L...    65   2e-09 
gi|3413906|dbj|BAA32317.1|  KIAA0472 protein [Homo sapiens]        65   2e-09 
gi|1093486|prf||2104208A  protein kinase C-related kinase:IS...    65   2e-09 
gi|54607118|ref|NP_056356.2|  leucine-rich repeats and immun...    64   3e-09 
gi|22713539|gb|AAH37166.1|  Ephrin receptor EphA2 [Homo sapi...    64   3e-09 
gi|107496|pir||A36355  protein-tyrosine kinase (EC 2.7.1.112...    64   3e-09 
gi|38648757|gb|AAH63282.1|  EPHA3 protein [Homo sapiens]           64   3e-09 
gi|14423349|gb|AAK62357.1|  membrane glycoprotein LRIG1 [Hom...    64   3e-09 
gi|2781151|pdb|3LCK|   The Kinase Domain Of Human Lymphocyte...    64   3e-09 
gi|4507831|ref|NP_003556.1|  unc-51-like kinase 1 [Homo sapi...    64   3e-09 
gi|21361241|ref|NP_005224.2|  ephrin receptor EphA3 isoform ...    64   3e-09 
gi|48734697|gb|AAH71561.1|  LRIG1 protein [Homo sapiens]           64   3e-09 
gi|37926808|pdb|1MQB|B  Chain B, Crystal Structure Of Ephrin...    64   3e-09 
gi|8569366|pdb|1QPJ|A  Chain A, Crystal Structure Of The Lym...    64   3e-09 
gi|13537355|dbj|BAB40659.1|  membrane glycoprotein LIG-1 [Ho...    64   3e-09 
gi|20521139|dbj|BAA34442.2|  KIAA0722 protein [Homo sapiens]       64   3e-09 
gi|42544153|ref|NP_002335.2|  leukocyte tyrosine kinase isof...    64   3e-09 
gi|22652263|gb|AAN03661.1|  novel kinase [Homo sapiens] >gi|...    64   3e-09 
gi|34420|emb|CAA43113.1|  tyrosine kinase [Homo sapiens]           64   3e-09 
gi|52355222|gb|AAU44786.1|  leucine-rich repeat protein LRIG...    64   3e-09 
gi|11056008|ref|NP_067647.1|  leucine-rich repeat-containing...    64   3e-09 
gi|55959024|emb|CAI15927.1|  leucine-rich repeat-containing ...    64   3e-09 
gi|46249416|ref|NP_996844.1|  leukocyte tyrosine kinase isof...    64   3e-09 
gi|440855|dbj|BAA03679.1|  leukocyte tyrosine kinase [Homo s...    64   3e-09 
gi|13447610|dbj|BAB39854.1|  VTS20631 [Homo sapiens]               64   3e-09 
gi|23512307|gb|AAH38448.1|  TESK1 protein [Homo sapiens] >gi...    64   4e-09 
gi|5454110|ref|NP_006276.1|  testis-specific protein kinase ...    64   4e-09 
gi|28950596|emb|CAD70625.1|  RIPK1 [Homo sapiens] >gi|572427...    64   4e-09 
gi|6466010|gb|AAF12758.1|  protein kinase [Homo sapiens] >gi...    64   4e-09 
gi|52078442|gb|AAH82244.1|  PLEKHE1 protein [Homo sapiens]         64   4e-09 
gi|7513330|pir||T09479  serine/threonine protein kinase (EC ...    64   4e-09 
gi|57999525|emb|CAI45969.1|  hypothetical protein [Homo sapi...    64   4e-09 
gi|31563382|ref|NP_037389.4|  serum/glucocorticoid regulated...    64   4e-09 
gi|38492557|pdb|1NXK|D  Chain D, Crystal Structure Of Stauro...    64   4e-09 
gi|10862701|ref|NP_065681.1|  ret proto-oncogene isoform c [...    63   6e-09 
gi|13186243|ref|NP_075418.1|  fibroblast growth factor recep...    63   6e-09 
gi|13186261|ref|NP_075262.1|  fibroblast growth factor recep...    63   6e-09 
gi|55953117|ref|NP_003943.2|  ribosomal protein S6 kinase, 7...    63   6e-09 
gi|38275|emb|CAA31408.1|  unnamed protein product [Homo sapi...    63   6e-09 
gi|10862703|ref|NP_066124.1|  ret proto-oncogene isoform a [...    63   6e-09 
gi|55962535|emb|CAI17115.1|  protein kinase, cGMP-dependent,...    63   6e-09 
gi|13186263|ref|NP_075263.1|  fibroblast growth factor recep...    63   6e-09 
gi|13186259|ref|NP_075261.1|  fibroblast growth factor recep...    63   6e-09 
gi|13186255|ref|NP_075259.1|  fibroblast growth factor recep...    63   6e-09 
gi|4503709|ref|NP_000132.1|  fibroblast growth factor recept...    63   6e-09 
gi|13186253|ref|NP_075258.1|  fibroblast growth factor recep...    63   6e-09 
gi|106231|pir||A35969  heparin-binding growth factor recepto...    63   6e-09 
gi|6382062|ref|NP_009298.1|  v-abl Abelson murine leukemia v...    63   6e-09 
gi|423137|pir||S33596  protein-tyrosine kinase (EC 2.7.1.112...    63   6e-09 
gi|32165606|gb|AAP72030.1|  cardiac ankyrin repeat kinase [H...    63   6e-09 
gi|25058745|gb|AAH39243.1|  FGFR2 protein [Homo sapiens]           63   6e-09 
gi|21620011|gb|AAH33085.1|  TESK2 protein [Homo sapiens]           63   6e-09 
gi|56611113|gb|AAH00094.3|  Ribosomal protein S6 kinase, 70k...    63   6e-09 
gi|13186269|ref|NP_075417.1|  fibroblast growth factor recep...    63   6e-09 
gi|6382060|ref|NP_005149.2|  v-abl Abelson murine leukemia v...    63   6e-09 
gi|3882085|dbj|BAA34402.1|  p70 ribosomal S6 kinase beta [Ho...    63   6e-09 
gi|22325362|ref|NP_665894.1|  leucine rich repeat and death ...    63   6e-09 
gi|55962534|emb|CAI17114.1|  protein kinase, cGMP-dependent,...    63   6e-09 
gi|57209582|emb|CAI40744.1|  protein kinase, cGMP-dependent,...    63   6e-09 
gi|56205993|emb|CAI21723.1|  testis-specific kinase 2 [Homo ...    63   6e-09 
gi|55959049|emb|CAI15584.1|  v-abl Abelson murine leukemia v...    63   6e-09 
gi|56611111|gb|AAH06106.3|  Ribosomal protein S6 kinase, 70k...    63   6e-09 
gi|22325360|ref|NP_665893.1|  leucine rich repeat and death ...    63   6e-09 
gi|27754769|ref|NP_075264.2|  fibroblast growth factor recep...    63   6e-09 
gi|15281418|gb|AAK94209.1|  keratinocyte growth factor recep...    63   6e-09 
gi|15281417|gb|AAK94208.1|  keratinocyte growth factor recep...    63   6e-09 
gi|15281415|gb|AAK94206.1|  keratinocyte growth factor recep...    63   6e-09 
gi|15281414|gb|AAK94205.1|  keratinocyte growth factor recep...    63   6e-09 
gi|3063840|emb|CAB07436.1|  cGMP-dependent protein kinase ty...    63   6e-09 
gi|31874804|emb|CAD98092.1|  hypothetical protein [Homo sapi...    63   6e-09 
gi|27260913|dbj|BAC45037.1|  isoform of FGFR2 [Homo sapiens]       63   6e-09 
gi|20380414|gb|AAH28164.1|  TNK2 protein [Homo sapiens]            63   6e-09 
gi|56549666|ref|NP_005772.3|  tyrosine kinase, non-receptor,...    63   6e-09 
gi|58331191|ref|NP_001010938.1|  tyrosine kinase, non-recept...    63   6e-09 
gi|4883534|gb|AAD31561.1|  fibroblast growth factor receptor...    63   6e-09 
gi|4883533|gb|AAD31560.1|  fibroblast growth receptor 2 IgII...    63   6e-09 
gi|88517|pir||JN0290  protein-tyrosine kinase (EC 2.7.1.112)...    63   6e-09 
gi|2135241|pir||I38153  gene retII protein - human >gi|36009...    63   6e-09 
gi|420088|pir||B34735  protein-tyrosine kinase (EC 2.7.1.112...    63   6e-09 
gi|88518|pir||JN0291  protein-tyrosine kinase (EC 2.7.1.112)...    63   6e-09 
gi|7434394|pir||JE0377  p70 S6 kinase (EC 2.7.-.-) - human >...    63   6e-09 
gi|42406387|gb|AAH65912.1|  ABL2 protein [Homo sapiens]            63   6e-09 
gi|47077584|dbj|BAD18675.1|  unnamed protein product [Homo s...    63   6e-09 
gi|37999491|sp|Q07912|ACK1_HUMAN  Activated CDC42 kinase 1 (...    63   6e-09 
gi|22218646|pdb|1GJO|A  Chain A, The Fgfr2 Tyrosine Kinase D...    63   6e-09 
gi|52696005|pdb|1U54|B  Chain B, Crystal Structures Of The P...    63   6e-09 
gi|52696004|pdb|1U54|A  Chain A, Crystal Structures Of The P...    63   6e-09 
gi|190700|gb|AAA36524.1|  papillary thyroid carcinoma-encode...    63   6e-09 
gi|285917|dbj|BAA03537.1|  large erk kinase [Homo sapiens]         63   8e-09 
gi|337358|gb|AAA60266.1|  RET tyrosine kinase/cAMP protein k...    63   8e-09 
gi|1100110|gb|AAA99310.1|  protein-tyrosine kinase >gi|15852...    63   8e-09 
gi|56205037|emb|CAI22899.1|  EPH receptor B2 [Homo sapiens] ...    63   8e-09 
gi|56205036|emb|CAI22898.1|  EPH receptor B2 [Homo sapiens] ...    63   8e-09 
gi|56205035|emb|CAI22897.1|  EPH receptor B2 [Homo sapiens] ...    63   8e-09 
gi|56202939|emb|CAI22644.1|  EPH receptor B2 [Homo sapiens] ...    63   8e-09 
gi|21389162|gb|AAM50515.1|  testis-specific kinase-1 [Homo s...    63   8e-09 
gi|495678|dbj|BAA06506.1|  tyrosine kinase precursor [Homo s...    63   8e-09 
gi|2136054|pir||A57174  protein-tyrosine kinase (EC 2.7.1.11...    63   8e-09 
gi|7434435|pir||I78842  receptor protein-tyrosine kinase - h...    63   8e-09 
gi|12644190|sp|P29323|EPHB2_HUMAN  Ephrin type-B receptor 2 ...    63   8e-09 
gi|7546569|pdb|1VR2|A  Chain A, Human Vascular Endothelial G...    63   8e-09 
gi|340026|gb|AAA36786.1|  tyrosine kinase                          63   8e-09 
gi|21752067|dbj|BAC04109.1|  unnamed protein product [Homo s...    62   1e-08 
gi|599827|emb|CAA56515.1|  serine/threonine protein kinase [...    62   1e-08 
gi|15341997|gb|AAH13200.1|  LCK protein [Homo sapiens]             62   1e-08 
gi|482917|emb|CAA81796.1|  receptor tyrosine kinase eph [Hom...    62   1e-08 
gi|41472551|gb|AAS07458.1|  unknown [Homo sapiens]                 62   1e-08 
gi|4507531|ref|NP_003256.1|  toll-like receptor 3 [Homo sapi...    62   1e-08 
gi|9845487|ref|NP_059672.1|  MAP/microtubule affinity-regula...    62   1e-08 
gi|37590301|gb|AAH59372.1|  TLR3 protein [Homo sapiens]            62   1e-08 
gi|37181344|gb|AAQ88486.1|  gonadotropin receptor [Homo sapi...    62   1e-08 
gi|34782791|gb|AAH08771.2|  MARK2 protein [Homo sapiens]           62   1e-08 
gi|51094534|gb|EAL23789.1|  EphA1 [Homo sapiens] >gi|4711783...    62   1e-08 
gi|55777408|gb|AAH47905.2|  Leucine-rich repeat-containing G...    62   1e-08 
gi|30583523|gb|AAP36006.1|  MAP/microtubule affinity-regulat...    62   1e-08 
gi|54261525|gb|AAH84540.1|  MARK2 protein [Homo sapiens]           62   1e-08 
gi|56204148|emb|CAI22321.1|  lymphocyte-specific protein tyr...    62   1e-08 
gi|45220438|dbj|BAD12234.1|  unnamed protein product [Homo s...    62   1e-08 
gi|7020356|dbj|BAA91094.1|  unnamed protein product [Homo sa...    62   1e-08 
gi|56119207|ref|NP_005223.3|  ephrin receptor EphA1 [Homo sa...    62   1e-08 
gi|7705841|ref|NP_057207.1|  interleukin-1 receptor-associat...    62   1e-08 
gi|9845489|ref|NP_004945.2|  MAP/microtubule affinity-regula...    62   1e-08 
gi|22658392|gb|AAH31231.1|  Serine/threonine kinase 33 [Homo...    62   1e-08 
gi|15042611|gb|AAK82368.1|  Ser/Thr protein kinase PAR-1Balp...    62   1e-08 
gi|17402861|gb|AAF27051.2|  SGK-like protein SGKL [Homo sapi...    62   1e-08 
gi|87779|pir||A34076  protein-tyrosine kinase (EC 2.7.1.112)...    62   1e-08 
gi|5453122|gb|AAD43440.1|  receptor tyrosine kinase [Homo sa...    62   1e-08 
gi|7446398|pir||G01025  serine/threonine protein kinase - human    62   1e-08 
gi|51534926|dbj|BAD37141.1|  serine/threonine kinase [Homo s...    62   1e-08 
gi|6691445|dbj|BAA89296.1|  K-sam-IIH1 [Homo sapiens]              62   1e-08 
gi|3135309|gb|AAC78793.1|  leucin rich neuronal protein [Hom...    62   1e-08 
gi|16552748|dbj|BAB71371.1|  unnamed protein product [Homo s...    62   1e-08 
gi|55958961|emb|CAI13114.1|  serine\/threonine kinase 24 (ST...    62   1e-08 
gi|23274191|gb|AAH35578.1|  STK24 protein [Homo sapiens] >gi...    62   1e-08 
gi|55957943|emb|CAC12904.2|  protein kinase C, theta [Homo s...    62   1e-08 
gi|1082565|pir||A55747  L-JAK protein-tyrosine kinase - huma...    62   1e-08 
gi|30181233|ref|NP_002310.2|  leucine-rich repeats and calpo...    62   1e-08 
gi|2582413|gb|AAB82560.1|  STE20-like kinase 3 [Homo sapiens]      62   1e-08 
gi|558099|gb|AAA75571.1|  protein kinase C-theta                   62   1e-08 
gi|55958960|emb|CAI13113.1|  serine\/threonine kinase 24 (ST...    62   1e-08 
gi|55957944|emb|CAI16128.1|  OTTHUMP00000043365 [Homo sapien...    62   1e-08 
gi|55957942|emb|CAI16127.1|  OTTHUMP00000043364 [Homo sapien...    62   1e-08 
gi|4503687|ref|NP_001996.1|  V-FES feline sarcoma viral/V-FP...    62   1e-08 
gi|39962915|gb|AAH64422.1|  PNCK protein [Homo sapiens]            62   1e-08 
gi|13279041|gb|AAH04257.1|  Ret proto-oncogene, isoform c [H...    62   1e-08 
gi|3132526|gb|AAC34376.1|  Toll/interleukin-1 receptor-like ...    62   1e-08 
gi|280850|pir||A43625  protein-tyrosine kinase (EC 2.7.1.112...    62   1e-08 
gi|41107636|gb|AAH65378.1|  STK24 protein [Homo sapiens]           62   1e-08 
gi|20140433|sp|O60602|TLR5_HUMAN  Toll-like receptor 5 precu...    62   1e-08 
gi|49456921|emb|CAG46781.1|  RAB6A [Homo sapiens]                  62   1e-08 
gi|56554577|pdb|1XJD|A  Chain A, Crystal Structure Of Pkc-Th...    62   1e-08 
gi|13960149|gb|AAH07514.1|  ARAF1 protein [Homo sapiens]           62   2e-08 
gi|4680397|emb|CAB41303.1|  guanylate cyclase 2F, retinal [H...    62   2e-08 
gi|5139484|emb|CAB45657.1|  OTTHUMP00000028888 [Homo sapiens]      62   2e-08 
gi|9837341|gb|AAG00534.1|  CamKI-like protein kinase [Homo s...    62   2e-08 
gi|1340152|emb|CAA28476.1|  unnamed protein product [Homo sa...    62   2e-08 
gi|4504219|ref|NP_001513.1|  guanylate cyclase 2F [Homo sapi...    62   2e-08 
gi|30582399|gb|AAP35426.1|  mitogen-activated protein kinase...    62   2e-08 
gi|54696590|gb|AAV38667.1|  v-raf murine sarcoma 3611 viral ...    62   2e-08 
gi|4885231|ref|NP_005237.1|  fer (fps/fes related) tyrosine ...    62   2e-08 
gi|54696264|gb|AAV38504.1|  RAB6A, member RAS oncogene famil...    62   2e-08 
gi|27805738|sp|Q9UQB9|AURKC_HUMAN  Serine/threonine-protein ...    62   2e-08 
gi|88515|pir||B26368  protein-serine kinase (EC 2.7.1.-) PSK...    62   2e-08 
gi|55962537|emb|CAI14675.1|  OTTHUMP00000045030 [Homo sapien...    62   2e-08 
gi|22477868|gb|AAH36797.1|  ADRBK2 protein [Homo sapiens]          62   2e-08 
gi|51471708|gb|AAU04399.1|  aurora-C [Homo sapiens]                62   2e-08 
gi|55957675|emb|CAI12893.1|  OTTHUMP00000040896 [Homo sapien...    62   2e-08 
gi|7263928|emb|CAB81612.1|  EPH receptor A8 [Homo sapiens] >...    62   2e-08 
gi|13161938|emb|CAC32991.1|  putative protein kinase WNK4 [H...    62   2e-08 
gi|50959740|gb|AAH75064.1|  Unknown (protein for IMAGE:30915...    62   2e-08 
gi|21729899|ref|NP_660145.1|  mitogen-activated protein kina...    62   2e-08 
gi|49338210|gb|AAT64422.1|  aurora/Ipl1-related kinase 3 tra...    62   2e-08 
gi|3298603|gb|AAC25955.1|  serine/threonine kinase AIE2 [Hom...    62   2e-08 
gi|7959179|dbj|BAA95983.1|  KIAA1459 protein [Homo sapiens]        62   2e-08 
gi|13186249|ref|NP_075599.1|  fibroblast growth factor recep...    61   2e-08 
gi|345763|pir||JC1469  beta-adrenergic-receptor kinase (EC 2...    61   2e-08 
gi|26667199|ref|NP_751910.1|  calcium/calmodulin-dependent p...    61   2e-08 
gi|21263106|gb|AAM44860.1|  Janus kinase 3 (a protein tyrosi...    61   2e-08 
gi|387023|gb|AAB08754.1|  raf related protein [Homo sapiens]       61   2e-08 
gi|55665674|emb|CAH73650.1|  EPHA7 [Homo sapiens] >gi|562035...    61   2e-08 
gi|30583365|gb|AAP35927.1|  RAB6B, member RAS oncogene famil...    61   2e-08 
gi|55961895|emb|CAI13789.1|  calcium\/calmodulin-dependent p...    61   2e-08 
gi|55961897|emb|CAI13791.1|  calcium\/calmodulin-dependent p...    61   2e-08 
gi|4758696|ref|NP_004712.1|  mitogen-activated protein kinas...    61   2e-08 
gi|26667211|ref|NP_751913.1|  calcium/calmodulin-dependent p...    61   2e-08 
gi|26667206|ref|NP_751912.1|  calcium/calmodulin-dependent p...    61   2e-08 
gi|55961894|emb|CAI13788.1|  calcium\/calmodulin-dependent p...    61   2e-08 
gi|284367|pir||S27966  probable serine/threonine-specific pr...    61   2e-08 
gi|55961896|emb|CAI13790.1|  calcium\/calmodulin-dependent p...    61   2e-08 
gi|55961893|emb|CAI13787.1|  calcium\/calmodulin-dependent p...    61   2e-08 
gi|21039158|gb|AAM33514.1|  calcium/calmodulin-dependent pro...    61   2e-08 
gi|26667203|ref|NP_751911.1|  calcium/calmodulin-dependent p...    61   2e-08 
gi|4885055|ref|NP_005151.1|  beta adrenergic receptor kinase...    61   2e-08 
gi|3089349|gb|AAC15093.1|  Cdc25C associated protein kinase ...    61   2e-08 
gi|19353236|gb|AAH24773.1|  MAP/microtubule affinity-regulat...    61   2e-08 
gi|21707842|gb|AAH34044.1|  Calcium/calmodulin-dependent pro...    61   2e-08 
gi|15042609|gb|AAK82367.1|  Ser/Thr protein kinase PAR-1A [H...    61   2e-08 
gi|1800225|gb|AAC50950.1|  JAK3 [Homo sapiens]                     61   2e-08 
gi|46852166|ref|NP_002367.4|  MAP/microtubule affinity-regul...    61   2e-08 
gi|2511440|gb|AAB80848.1|  calcium/calmodulin-dependent prot...    61   2e-08 
gi|2204281|gb|AAB61379.1|  calcium/calmodulin-dependent prot...    61   2e-08 
gi|20178304|sp|Q13555|KCC2G_HUMAN  Calcium/calmodulin-depend...    61   2e-08 
gi|18448971|gb|AAL69982.1|  MAP/microtubule affinity-regulat...    61   2e-08 
gi|6088096|dbj|BAA85625.1|  protein kinase PKNbeta [Homo sap...    61   2e-08 
gi|37545085|ref|XP_292678.2|  PREDICTED: similar to RIKEN cD...    61   3e-08 
gi|10440103|dbj|BAB15648.1|  unnamed protein product [Homo s...    61   3e-08 
gi|11321597|ref|NP_002244.1|  kinase insert domain receptor ...    61   3e-08 
gi|7662102|ref|NP_056379.1|  leucine rich repeat transmembra...    61   3e-08 
gi|31718|emb|CAA43837.1|  membrane protein [Homo sapiens] >g...    61   3e-08 
gi|56205994|emb|CAI21724.1|  testis-specific kinase 2 [Homo ...    61   3e-08 
gi|16741621|gb|AAH16615.1|  RAB37, member RAS oncogene famil...    61   3e-08 
gi|400127|sp|P07332|FES_HUMAN  Proto-oncogene tyrosine-prote...    61   3e-08 
gi|55957674|emb|CAI12892.1|  OTTHUMP00000018442 [Homo sapiens]     61   3e-08 
gi|57997199|emb|CAI46210.1|  hypothetical protein [Homo sapi...    61   3e-08 
gi|3127068|gb|AAC77369.1|  serine/threonine kinase 13 [Homo ...    61   3e-08 
gi|6005896|ref|NP_009101.1|  testis-specific protein kinase ...    61   3e-08 
gi|40788250|dbj|BAA24846.2|  KIAA0416 [Homo sapiens]               61   3e-08 
gi|3132833|gb|AAC16450.1|  vascular endothelial growth facto...    61   3e-08 
gi|40217803|ref|NP_079337.2|  hypothetical protein FLJ23420 ...    61   3e-08 
gi|47125302|gb|AAH70089.1|  Hypothetical protein FLJ23420 [H...    61   3e-08 
gi|7446386|pir||JC1402  protein-tyrosine kinase (EC 2.7.1.11...    61   3e-08 
gi|45946091|gb|AAH22216.2|  FLJ23420 protein [Homo sapiens]        61   3e-08 
gi|21740244|emb|CAD39133.1|  hypothetical protein [Homo sapi...    61   3e-08 
gi|56203813|emb|CAI23379.1|  v-ros UR2 sarcoma virus oncogen...    60   4e-08 
gi|56203812|emb|CAI23378.1|  OTTHUMP00000040389 [Homo sapien...    60   4e-08 


Alignments

>gi|55740398|gb|AAV63975.1|   leucine-rich repeat kinase 2 [Homo sapiens]
          Length = 2527

 Score = 3303 bits (8564), Expect = 0.0
 Identities = 1767/2265 (78%), Positives = 1831/2265 (80%), Gaps = 274/2265 (12%)

Query: 105  VGNDWEVL---GVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILD------- 154
            +GN + +L    VH+ ++K +  +  +  L +  L  L LL  +  +   + +       
Sbjct: 279  LGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQEN 338

Query: 155  ----EESDIFML--IFDAMHSFPANDEVQKLGCKALHVLFERGNNVEVLMS---GNVRCY 205
                EE  +F L   + A+     N  VQ+  C AL+ L    N++   +    G+   +
Sbjct: 339  DDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAH 398

Query: 206  NIVVEAMKAFPMSERIQEVSCCLLHRLTLGN--FFNILVLNEVHEFVVKAVQQYPENAAL 263
              V+ +M     S+ + + S   L  L   N  F  IL+   +H  V++ +Q++  +   
Sbjct: 399  REVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSP-- 456

Query: 264  QISALSCLALLRSFPGICECIVNSLRTKCNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 323
            +++   C  L   F G             NTSLDIMAAVVPKILTVMKRHETSLPVQLEA
Sbjct: 457  EVAESGCKMLNHLFEG------------SNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 504

Query: 324  LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 383
            LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL
Sbjct: 505  LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 564

Query: 384  KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 443
            KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG
Sbjct: 565  KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 624

Query: 444  HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 503
            HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM
Sbjct: 625  HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 684

Query: 504  EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 563
            EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL
Sbjct: 685  EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 744

Query: 564  ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 623
            ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC
Sbjct: 745  ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 804

Query: 624  LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 683
            LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF
Sbjct: 805  LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 864

Query: 684  SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 743
            SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR
Sbjct: 865  SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 924

Query: 744  CSPNLQRHSNSL---------------------TLKSLTHLDLHSNKFTSFPSYLLKMSC 782
            CSPNLQRHSNSL                     +L+S + L  H     S  S   +   
Sbjct: 925  CSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRS-SKLQSHMRHSDSISSLASEREY 983

Query: 783  IANLDVSRNDIGPSVVLDP----TVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILE 838
            I +LD+S N++     L      +V    L++  L  N L+  P+ L + ++ L  L L 
Sbjct: 984  ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 1043

Query: 839  GNKISGICSPL--------------------------RLKELKILNLSKNHISSLSEN-- 870
             NK +   S L                          +   LK  NLS N +S + EN  
Sbjct: 1044 SNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLT 1103

Query: 871  --------------------------------------------FLEACPKVESFSARMN 886
                                                        FLEACPKVESFSARMN
Sbjct: 1104 DVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMN 1163

Query: 887  FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946
            FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR
Sbjct: 1164 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 1223

Query: 947  ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006
            ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS
Sbjct: 1224 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1283

Query: 1007 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1066
            FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT
Sbjct: 1284 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1343

Query: 1067 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1126
            GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS
Sbjct: 1344 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1403

Query: 1127 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1186
            THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK
Sbjct: 1404 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1463

Query: 1187 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1246
            ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI
Sbjct: 1464 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1523

Query: 1247 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES---- 1302
            PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES    
Sbjct: 1524 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLL 1583

Query: 1303 -----------------------------VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1333
                                         VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK
Sbjct: 1584 HFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1643

Query: 1334 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1393
            NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG
Sbjct: 1644 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1703

Query: 1394 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1453
            FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL
Sbjct: 1704 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1763

Query: 1454 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1513
            KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ
Sbjct: 1764 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1823

Query: 1514 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1573
            KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF
Sbjct: 1824 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1883

Query: 1574 LL----------------------------------------------------AGIRPR 1581
            LL                                                    AGIRPR
Sbjct: 1884 LLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPR 1943

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF
Sbjct: 1944 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 2003

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
            TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL
Sbjct: 2004 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 2063

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP
Sbjct: 2064 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 2123

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 1821
            TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD
Sbjct: 2124 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 2183

Query: 1822 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 1881
            LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD
Sbjct: 2184 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 2243

Query: 1882 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 1941
            SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL
Sbjct: 2244 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 2303

Query: 1942 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2001
            SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL
Sbjct: 2304 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2363

Query: 2002 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLSVIWMVLEGHTVKHK---TGSLKNV----- 2053
            YIAKQNSPVVEVWDKKTEKLCGLIDCVHFL  + MV E    KHK   +G +K +     
Sbjct: 2364 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREV-MVKENKESKHKMSYSGRVKTLCLQKN 2422

Query: 2054 -----------------------------------------------MLVLGYNRKNTEG 2066
                                                           MLVLGYNRKNTEG
Sbjct: 2423 TALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEG 2482

Query: 2067 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2111
            TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
Sbjct: 2483 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2527



 Score =  512 bits (1318), Expect = e-144
 Identities = 272/319 (85%), Positives = 272/319 (85%), Gaps = 45/319 (14%)

Query: 1   MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI 60
           MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSE ASKLFQGKNI
Sbjct: 1   MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI 60

Query: 61  HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120
           HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
Sbjct: 61  HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120

Query: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180
           MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
Sbjct: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180

Query: 181 CKALHVLFER---------------------------------------------GNNVE 195
           CKALHVLFER                                              NNVE
Sbjct: 181 CKALHVLFERVSEEQLTEFVENKDYMILLSASTNFKDEEEIVLHVLHCLHSLAIPCNNVE 240

Query: 196 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ 255
           VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
Sbjct: 241 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ 300

Query: 256 QYPENAALQISALSCLALL 274
           QYPENAALQISALSCLALL
Sbjct: 301 QYPENAALQISALSCLALL 319



>gi|41149741|ref|XP_058513.7|   PREDICTED: similar to RIKEN cDNA 4921513O20; cDNA sequence, clone
            3-75 [Homo sapiens]
          Length = 2482

 Score = 3303 bits (8564), Expect = 0.0
 Identities = 1767/2265 (78%), Positives = 1831/2265 (80%), Gaps = 274/2265 (12%)

Query: 105  VGNDWEVL---GVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILD------- 154
            +GN + +L    VH+ ++K +  +  +  L +  L  L LL  +  +   + +       
Sbjct: 234  LGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQEN 293

Query: 155  ----EESDIFML--IFDAMHSFPANDEVQKLGCKALHVLFERGNNVEVLMS---GNVRCY 205
                EE  +F L   + A+     N  VQ+  C AL+ L    N++   +    G+   +
Sbjct: 294  DDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAH 353

Query: 206  NIVVEAMKAFPMSERIQEVSCCLLHRLTLGN--FFNILVLNEVHEFVVKAVQQYPENAAL 263
              V+ +M     S+ + + S   L  L   N  F  IL+   +H  V++ +Q++  +   
Sbjct: 354  REVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSP-- 411

Query: 264  QISALSCLALLRSFPGICECIVNSLRTKCNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 323
            +++   C  L   F G             NTSLDIMAAVVPKILTVMKRHETSLPVQLEA
Sbjct: 412  EVAESGCKMLNHLFEG------------SNTSLDIMAAVVPKILTVMKRHETSLPVQLEA 459

Query: 324  LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 383
            LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL
Sbjct: 460  LRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGL 519

Query: 384  KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 443
            KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG
Sbjct: 520  KVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG 579

Query: 444  HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 503
            HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM
Sbjct: 580  HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIM 639

Query: 504  EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 563
            EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL
Sbjct: 640  EQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSL 699

Query: 564  ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 623
            ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC
Sbjct: 700  ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSIC 759

Query: 624  LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 683
            LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF
Sbjct: 760  LGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNF 819

Query: 684  SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 743
            SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR
Sbjct: 820  SEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQR 879

Query: 744  CSPNLQRHSNSL---------------------TLKSLTHLDLHSNKFTSFPSYLLKMSC 782
            CSPNLQRHSNSL                     +L+S + L  H     S  S   +   
Sbjct: 880  CSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRS-SKLQSHMRHSDSISSLASEREY 938

Query: 783  IANLDVSRNDIGPSVVLDP----TVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILE 838
            I +LD+S N++     L      +V    L++  L  N L+  P+ L + ++ L  L L 
Sbjct: 939  ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 998

Query: 839  GNKISGICSPL--------------------------RLKELKILNLSKNHISSLSEN-- 870
             NK +   S L                          +   LK  NLS N +S + EN  
Sbjct: 999  SNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLT 1058

Query: 871  --------------------------------------------FLEACPKVESFSARMN 886
                                                        FLEACPKVESFSARMN
Sbjct: 1059 DVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMN 1118

Query: 887  FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946
            FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR
Sbjct: 1119 FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 1178

Query: 947  ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006
            ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS
Sbjct: 1179 ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1238

Query: 1007 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1066
            FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT
Sbjct: 1239 FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNT 1298

Query: 1067 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1126
            GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS
Sbjct: 1299 GSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYS 1358

Query: 1127 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1186
            THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK
Sbjct: 1359 THPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRK 1418

Query: 1187 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1246
            ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI
Sbjct: 1419 ACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI 1478

Query: 1247 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES---- 1302
            PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNES    
Sbjct: 1479 PDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLL 1538

Query: 1303 -----------------------------VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1333
                                         VKVEGCPKHPKGIISRRDVEKFLSKKRKFPK
Sbjct: 1539 HFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPK 1598

Query: 1334 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1393
            NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG
Sbjct: 1599 NYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMG 1658

Query: 1394 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1453
            FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL
Sbjct: 1659 FWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFL 1718

Query: 1454 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1513
            KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ
Sbjct: 1719 KITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1778

Query: 1514 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1573
            KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF
Sbjct: 1779 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1838

Query: 1574 LL----------------------------------------------------AGIRPR 1581
            LL                                                    AGIRPR
Sbjct: 1839 LLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPR 1898

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF
Sbjct: 1899 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1958

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
            TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL
Sbjct: 1959 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 2018

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP
Sbjct: 2019 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 2078

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 1821
            TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD
Sbjct: 2079 TSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLD 2138

Query: 1822 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 1881
            LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD
Sbjct: 2139 LNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTD 2198

Query: 1882 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 1941
            SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL
Sbjct: 2199 SVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCL 2258

Query: 1942 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2001
            SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL
Sbjct: 2259 SESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTAL 2318

Query: 2002 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLSVIWMVLEGHTVKHK---TGSLKNV----- 2053
            YIAKQNSPVVEVWDKKTEKLCGLIDCVHFL  + MV E    KHK   +G +K +     
Sbjct: 2319 YIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREV-MVKENKESKHKMSYSGRVKTLCLQKN 2377

Query: 2054 -----------------------------------------------MLVLGYNRKNTEG 2066
                                                           MLVLGYNRKNTEG
Sbjct: 2378 TALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEG 2437

Query: 2067 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2111
            TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
Sbjct: 2438 TQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2482



 Score =  539 bits (1388), Expect = e-152
 Identities = 274/274 (100%), Positives = 274/274 (100%)

Query: 1   MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI 60
           MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI
Sbjct: 1   MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI 60

Query: 61  HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120
           HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
Sbjct: 61  HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120

Query: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180
           MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
Sbjct: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180

Query: 181 CKALHVLFERGNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNI 240
           CKALHVLFERGNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNI
Sbjct: 181 CKALHVLFERGNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNI 240

Query: 241 LVLNEVHEFVVKAVQQYPENAALQISALSCLALL 274
           LVLNEVHEFVVKAVQQYPENAALQISALSCLALL
Sbjct: 241 LVLNEVHEFVVKAVQQYPENAALQISALSCLALL 274



>gi|34534766|dbj|BAC87105.1|   unnamed protein product [Homo sapiens]
          Length = 870

 Score = 1132 bits (2928), Expect = 0.0
 Identities = 621/845 (73%), Positives = 653/845 (77%), Gaps = 112/845 (13%)

Query: 236 NFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLRSFPGICECIVNSLRTKCNTS 295
           NF  IL+   +H  V++ +Q++  +   +++   C  L   F G             NTS
Sbjct: 30  NFRKILLSKGIHLNVLELMQKHIHSP--EVAESGCKMLNHLFEG------------SNTS 75

Query: 296 LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQ 355
           LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQ
Sbjct: 76  LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQ 135

Query: 356 CFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY 415
           CFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY
Sbjct: 136 CFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMY 195

Query: 416 PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAIL 475
           PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAIL
Sbjct: 196 PDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAIL 255

Query: 476 KLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERA 535
           KLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERA
Sbjct: 256 KLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERA 315

Query: 536 CDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT 595
           CDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT
Sbjct: 316 CDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALT 375

Query: 596 ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIA 655
           ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIA
Sbjct: 376 ISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIA 435

Query: 656 STLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSE 715
           STLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSE
Sbjct: 436 STLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSE 495

Query: 716 GSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL-------------------- 755
           GSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL                    
Sbjct: 496 GSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSD 555

Query: 756 -TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDP----TVKCPTLKQ 810
            +L+S + L  H     S  S   +   I +LD+S N++     L      +V    L++
Sbjct: 556 DSLRS-SKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEK 614

Query: 811 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL--------------------- 849
             L  N L+  P+ L + ++ L  L L  NK +   S L                     
Sbjct: 615 LELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVV 674

Query: 850 -----RLKELKILNLSKNHISSLSEN---------------------------------- 870
                +   LK  NLS N +S + EN                                  
Sbjct: 675 LDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILN 734

Query: 871 ------------FLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNL 918
                       FLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNL
Sbjct: 735 LSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNL 794

Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978
           PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN
Sbjct: 795 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 854

Query: 979 KLKEI 983
           KLKE+
Sbjct: 855 KLKEV 859



 Score = 33.9 bits (76), Expect = 3.8
 Identities = 52/251 (20%), Positives = 109/251 (43%), Gaps = 33/251 (13%)

Query: 53  KLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVL 112
           K+   K IH+ +L ++  ++    V + G  +L  L E   G+  SL    D+     + 
Sbjct: 33  KILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFE---GSNTSL----DI-----MA 80

Query: 113 GVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEE--------------SD 158
            V   IL ++  H  S+ + +  L+ +   +  G       D E              +D
Sbjct: 81  AVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKND 140

Query: 159 IFMLIFDAMHSFPANDEVQKLGCKALHVLFERGNNVEVL-MSGNVRCYNIVVEAMKAFPM 217
           I  L+  A++ F  N  +QK G K +  +    + +E+L + G     + V+  ++ +P 
Sbjct: 141 IHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEG---AMDSVLHTLQMYPD 197

Query: 218 SERIQEVSCCLL-HRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISAL-SCLALLR 275
            + IQ +   L+ + +T  N F I   + + + +V ++ ++ + A +Q     + LA+L+
Sbjct: 198 DQEIQCLGLSLIGYLITKKNVF-IGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILK 256

Query: 276 SFPGICECIVN 286
                 + +V+
Sbjct: 257 LSASFSKLLVH 267



>gi|21740356|emb|CAD39185.1|   hypothetical protein [Homo sapiens]
          Length = 400

 Score =  631 bits (1627), Expect = e-180
 Identities = 332/401 (82%), Positives = 336/401 (83%), Gaps = 56/401 (13%)

Query: 1766 VFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTE 1825
            VFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTE
Sbjct: 1    VFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTE 60

Query: 1826 GYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTC 1885
            GYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTC
Sbjct: 61   GYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTC 120

Query: 1886 LYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSEST 1945
            LYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSEST
Sbjct: 121  LYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSEST 180

Query: 1946 NSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAK 2005
            NSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAK
Sbjct: 181  NSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAK 240

Query: 2006 QNSPVVEVWDKKTEKLCGLIDCVHFLSVIWMVLEGHTVKHK---TGSLKNV--------- 2053
            QNSPVVEVWDKKTEKLCGLIDCVHFL  + MV E    KHK   +G +K +         
Sbjct: 241  QNSPVVEVWDKKTEKLCGLIDCVHFLREV-MVKENKESKHKMSYSGRVKTLCLQKNTALW 299

Query: 2054 -------------------------------------------MLVLGYNRKNTEGTQKQ 2070
                                                       MLVLGYNRKNTEGTQKQ
Sbjct: 300  IGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQ 359

Query: 2071 KEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 2111
            KEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE
Sbjct: 360  KEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE 400



>gi|14017797|dbj|BAB47419.1|   KIAA1790 protein [Homo sapiens]
          Length = 1369

 Score =  161 bits (408), Expect = 1e-38
 Identities = 149/600 (24%), Positives = 268/600 (44%), Gaps = 106/600 (17%)

Query: 1069 GKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLV----LNVWDFAGREEF 1124
            GK+TLL+ L   +   +    AT  I    W +Q R    R  V     NVWD  G    
Sbjct: 4    GKSTLLEILQTGRAPQVVHGEAT--IRTTKWELQ-RPAGSRAKVESVEFNVWDIGGPASM 60

Query: 1125 YSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQ 1184
             + +  F T +ALY+ V++L+ G+  V  ++ WL NI+A+A ++ V++VGTHLD+ + K 
Sbjct: 61   ATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKF 120

Query: 1185 RKACMSKITKELL---------NKRGFPAIRDYHFVNATEES-DALAKLRKTIINESLNF 1234
            R   ++ +   +L            GFP I   H    + +S +    LR+ I + + + 
Sbjct: 121  RVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSM 180

Query: 1235 K-----IRDQLVVGQLIPDCYVELEKIILSE--RKNVPIEFPVIDRKRLLQLVRE---NQ 1284
            K     I  Q + G+LIP  Y+ L++ +L+E  R++   +   +  ++L QLV +   N 
Sbjct: 181  KDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDND 240

Query: 1285 LQLDENELPHAVHFLNES-------------------------------VKVEGCPKHPK 1313
            ++ D  +L  A+ FL E+                                 ++G     K
Sbjct: 241  IK-DYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAK 299

Query: 1314 GIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELP 1373
              + R +  + L     F +    QYF+ L KF+IALP+  +  L+P  L   +P ++  
Sbjct: 300  NGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTH 358

Query: 1374 HCEN--SEIIIRLYEMPYFPMGFWSRLINRLL----------------------EISPYM 1409
               +  +  I R+++M + P+GFW R I R+L                      +++ Y 
Sbjct: 359  GMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYS 418

Query: 1410 LSGRE-------RALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPES-FLKITVPSCR 1461
             +G +       R  R   +YW++G+ + +      +  S+V     +S  +KI   S  
Sbjct: 419  FTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEV 478

Query: 1462 KGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDG 1509
            +    +  + DH++SL+++WFP L   +   +G  L+++          WA ++      
Sbjct: 479  RDFSAMAFITDHVNSLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKS 536

Query: 1510 EEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQ 1569
            E+ Q   ++D +  A E D +  P  P L +P+ ++ P+L + D P  + L N +LE  +
Sbjct: 537  EDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSE 596



 Score =  102 bits (255), Expect = 7e-21
 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%)

Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632
            I P    +ELA   SL+ +L ++        L   L  +IA  +A GL YLH   II+ D
Sbjct: 681  IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 740

Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692
            LK  N+L+++L     I  K++DYGI++     G    EGTPG++APE+ R  ++Y+++ 
Sbjct: 741  LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 799

Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748
            D++S+G++LY++L +G R   G        +L+I  KL   ++     P    +  ++ L
Sbjct: 800  DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 852

Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808
            + +C    P++RP +  V   +           +   K        ++         W G
Sbjct: 853  MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 909

Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865
                     ++  +NTE    E     R+ C  +     L V++  W  + T+   + + 
Sbjct: 910  ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 960

Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913
              +     +T ++  D+   + C       K+ ++L L G ADG +A+F
Sbjct: 961  TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 1009



>gi|33469143|ref|NP_078928.2|   leucine-rich repeat kinase 1 [Homo sapiens]
          Length = 1310

 Score =  147 bits (371), Expect = 2e-34
 Identities = 130/534 (24%), Positives = 242/534 (45%), Gaps = 99/534 (18%)

Query: 1131 FMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMS 1190
            F T +ALY+ V++L+ G+  V  ++ WL NI+A+A ++ V++VGTHLD+ + K R   ++
Sbjct: 8    FFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIA 67

Query: 1191 KITKELL---------NKRGFPAIRDYHFVNATEES-DALAKLRKTIINESLNFK----- 1235
             +   +L            GFP I   H    + +S +    LR+ I + + + K     
Sbjct: 68   TLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGST 127

Query: 1236 IRDQLVVGQLIPDCYVELEKIILSE--RKNVPIEFPVIDRKRLLQLVRE---NQLQLDEN 1290
            I  Q + G+LIP  Y+ L++ +L+E  R++   +   +  ++L QLV +   N ++ D  
Sbjct: 128  IGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIK-DYE 186

Query: 1291 ELPHAVHFLNES-------------------------------VKVEGCPKHPKGIISRR 1319
            +L  A+ FL E+                                 ++G     K  + R 
Sbjct: 187  DLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRA 246

Query: 1320 DVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCEN-- 1377
            +  + L     F +    QYF+ L KF+IALP+  +  L+P  L   +P ++     +  
Sbjct: 247  EDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTHGMRHPT 305

Query: 1378 SEIIIRLYEMPYFPMGFWSRLINRLL----------------------EISPYMLSGRE- 1414
            +  I R+++M + P+GFW R I R+L                      +++ Y  +G + 
Sbjct: 306  ANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQR 365

Query: 1415 ------RALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPES-FLKITVPSCRKGCILL 1467
                  R  R   +YW++G+ + +      +  S+V     +S  +KI   S  +    +
Sbjct: 366  NRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAM 425

Query: 1468 GQVVDHIDSLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDGEEHQKI 1515
              + DH++SL+++WFP L   +   +G  L+++          WA ++      E+ Q  
Sbjct: 426  AFITDHVNSLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYF 483

Query: 1516 LLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQ 1569
             ++D +  A E D +  P  P L +P+ ++ P+L + D P  + L N +LE  +
Sbjct: 484  DMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSE 537



 Score =  102 bits (255), Expect = 7e-21
 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%)

Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632
            I P    +ELA   SL+ +L ++        L   L  +IA  +A GL YLH   II+ D
Sbjct: 622  IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 681

Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692
            LK  N+L+++L     I  K++DYGI++     G    EGTPG++APE+ R  ++Y+++ 
Sbjct: 682  LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 740

Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748
            D++S+G++LY++L +G R   G        +L+I  KL   ++     P    +  ++ L
Sbjct: 741  DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 793

Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808
            + +C    P++RP +  V   +           +   K        ++         W G
Sbjct: 794  MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 850

Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865
                     ++  +NTE    E     R+ C  +     L V++  W  + T+   + + 
Sbjct: 851  ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 901

Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913
              +     +T ++  D+   + C       K+ ++L L G ADG +A+F
Sbjct: 902  TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 950



>gi|4758704|ref|NP_004216.1|   malignant fibrous histiocytoma amplified sequence 1 [Homo sapiens]
 gi|4239895|dbj|BAA74737.1|   MASL1 [Homo sapiens]
          Length = 1052

 Score =  108 bits (271), Expect = 9e-23
 Identities = 128/501 (25%), Positives = 227/501 (45%), Gaps = 67/501 (13%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT-LKQFNLSY 815
            L+ L  L+L  N+  + P+ L  ++ +  LDVS N +     L  ++ C + L+  ++ +
Sbjct: 134  LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH---LPDSLSCLSRLRTLDVDH 190

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLSENFLEA 874
            NQL+  P  L  +V  LE+L +  N++ G+   +  L+ LKIL LS   + +L   F E 
Sbjct: 191  NQLTAFPRQLLQLVA-LEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCEL 249

Query: 875  CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
               +ES     N L A+P              +FSC       L  L+ L++SSN  +  
Sbjct: 250  A-SLESLMLDNNGLQALPA-------------QFSC-------LQRLKMLNLSSNLFEEF 288

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994
            P  A      L EL  S NQ++ +          R+  L L +N+++ +P  I  L  L 
Sbjct: 289  PA-ALLPLAGLEELYLSRNQLTSVPSLISGL--GRLLTLWLDNNRIRYLPDSIVELTGLE 345

Query: 995  SLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054
             L +  N ++   P+  G+LS++    + +  L      +  K    I   Q+ L  + P
Sbjct: 346  ELVLQGN-QIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQP 404

Query: 1055 --YNRMKLMIVGNTGSGKTTLLQQLM------------KTKKSDLGMQSATVGIDVKDWP 1100
                R+KL+++G+  +GKT L   L             K K         + GI+V  W 
Sbjct: 405  AVQPRLKLLLMGHKAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWT 464

Query: 1101 IQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAE--VDAMKPWL 1158
                    R L   V+D AG E +    P F++  ALY+ V +L+  +       +  +L
Sbjct: 465  ADA----SRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFL 520

Query: 1159 FNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESD 1218
              + AR  ++ V +VGTH D+  E++ +     I +++       A+++ H      +++
Sbjct: 521  HRVGARVPNAVVCIVGTHADLCGERELEEKCLDIHRQI-------ALQEKH------DAE 567

Query: 1219 ALAKLRKTIINESL--NFKIR 1237
             L++L K +++E+L  +F++R
Sbjct: 568  GLSRLAK-VVDEALARDFELR 587



 Score = 58.9 bits (141), Expect = 1e-07
 Identities = 48/180 (26%), Positives = 78/180 (43%), Gaps = 45/180 (25%)

Query: 848  PLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNK 907
            P  L +++ LNL  N +  + E    A                      S+ +L L +N+
Sbjct: 59   PANLGDIEALNLGNNGLEEVPEGLGSALG--------------------SLRVLVLRRNR 98

Query: 908  FSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLW 967
            F+ +P A+  L H                       +L EL  SHN+++ L  +E     
Sbjct: 99   FARLPPAVAELGH-----------------------HLTELDVSHNRLTALG-AEVVSAL 134

Query: 968  SRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027
              + KL+LSHN+L  +P ++G L +L  LDVS+N  L   P+ +  LS++  L +D   L
Sbjct: 135  RELRKLNLSHNQLPALPAQLGALAHLEELDVSFN-RLAHLPDSLSCLSRLRTLDVDHNQL 193



>gi|34526495|dbj|BAC85125.1|   FLJ00262 protein [Homo sapiens]
          Length = 1112

 Score =  102 bits (255), Expect = 7e-21
 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%)

Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632
            I P    +ELA   SL+ +L ++        L   L  +IA  +A GL YLH   II+ D
Sbjct: 424  IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 483

Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692
            LK  N+L+++L     I  K++DYGI++     G    EGTPG++APE+ R  ++Y+++ 
Sbjct: 484  LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 542

Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748
            D++S+G++LY++L +G R   G        +L+I  KL   ++     P    +  ++ L
Sbjct: 543  DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 595

Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808
            + +C    P++RP +  V   +           +   K        ++         W G
Sbjct: 596  MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 652

Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865
                     ++  +NTE    E     R+ C  +     L V++  W  + T+   + + 
Sbjct: 653  ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 703

Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913
              +     +T ++  D+   + C       K+ ++L L G ADG +A+F
Sbjct: 704  TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 752



 Score = 97.4 bits (241), Expect = 3e-19
 Identities = 73/300 (24%), Positives = 137/300 (45%), Gaps = 48/300 (16%)

Query: 1314 GIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELP 1373
            G+I   D+ + L     F +    QYF+ L KF+IALP+  +  L+P  L   +P ++  
Sbjct: 44   GVIRAEDL-RMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTH 101

Query: 1374 HCEN--SEIIIRLYEMPYFPMGFWSRLINRLL----------------------EISPYM 1409
               +  +  I R+++M + P+GFW R I R+L                      +++ Y 
Sbjct: 102  GMRHPTANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYS 161

Query: 1410 LSGRE-------RALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPES-FLKITVPSCR 1461
             +G +       R  R   +YW++G+ + +      +  S+V     +S  +KI   S  
Sbjct: 162  FTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEV 221

Query: 1462 KGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDG 1509
            +    +  + DH++SL+++WFP L   +   +G  L+++          WA ++      
Sbjct: 222  RDFSAMAFITDHVNSLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKS 279

Query: 1510 EEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQ 1569
            E+ Q   ++D +  A E D +  P  P L +P+ ++ P+L + D P  + L N +LE  +
Sbjct: 280  EDVQYFDMEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSE 339



>gi|31416932|gb|AAH05408.2|   LRRK1 protein [Homo sapiens]
          Length = 659

 Score =  102 bits (255), Expect = 7e-21
 Identities = 88/349 (25%), Positives = 158/349 (45%), Gaps = 33/349 (9%)

Query: 1578 IRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRYLHSAMIIYRD 1632
            I P    +ELA   SL+ +L ++        L   L  +IA  +A GL YLH   II+ D
Sbjct: 3    IHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD 62

Query: 1633 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQA 1692
            LK  N+L+++L     I  K++DYGI++     G    EGTPG++APE+ R  ++Y+++ 
Sbjct: 63   LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI-RPRIVYDEKV 121

Query: 1693 DVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP----WPMVEKL 1748
            D++S+G++LY++L +G R   G        +L+I  KL   ++     P    +  ++ L
Sbjct: 122  DMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQAL 174

Query: 1749 IKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLG 1808
            + +C    P++RP +  V   +           +   K        ++         W G
Sbjct: 175  MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQGQEYTVVFWDG 231

Query: 1809 CGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVSGTQSGTLLVI 1865
                     ++  +NTE    E     R+ C  +     L V++  W  + T+   + + 
Sbjct: 232  ----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--TATEDQKIYIY 282

Query: 1866 NTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 1913
              +     +T ++  D+   + C       K+ ++L L G ADG +A+F
Sbjct: 283  TLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 331



>gi|55661683|emb|CAH72812.1|   OTTHUMP00000058851 [Homo sapiens]
 gi|29792199|gb|AAH50445.1|   Soc-2 suppressor of clear homolog [Homo sapiens]
 gi|41281398|ref|NP_031399.2|   soc-2 suppressor of clear homolog [Homo sapiens]
 gi|3252979|gb|AAC39856.1|   Ras-binding protein SUR-8 [Homo sapiens]
 gi|3293320|gb|AAC25698.1|   leucine-rich repeat protein SHOC-2 [Homo sapiens]
 gi|14423936|sp|Q9UQ13|SHO2_HUMAN   Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8)
          Length = 582

 Score = 94.7 bits (234), Expect = 2e-18
 Identities = 83/327 (25%), Positives = 141/327 (43%), Gaps = 36/327 (11%)

Query: 760  LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLS 819
            +T+LDL  N+    P  +  +S ++ L +  N +  S +     KC  L++ NL  N +S
Sbjct: 263  ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENNNIS 320

Query: 820  FVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEACPK 877
             +PE+L   + KL  L L  N  ++  +  P +   +  LN+  N I+ +          
Sbjct: 321  TLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKV 380

Query: 878  VESFSARMNFLAAMPF--------------------LPP------SMTILKLSQNKFSCI 911
            +   + + N L ++P                     +P       S+ +L LS N    +
Sbjct: 381  LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 440

Query: 912  PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971
            P  + NL  LR LD+  N ++ LP    +   +L++L+ ++NQ++ L         + + 
Sbjct: 441  PHGLGNLRKLRELDLEENKLESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHL--TNLT 497

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDF 1031
             L L  N L  +P EIG LENL  L ++ N  L S P E+   SK+  + ++   L+   
Sbjct: 498  HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLP 557

Query: 1032 KHIGCKAKDIIRFLQQRLKKAVPYNRM 1058
              I         F+ Q LK   PY  M
Sbjct: 558  PQIVAGGPS---FIIQFLKMQGPYRAM 581



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 62/223 (27%), Positives = 114/223 (51%), Gaps = 10/223 (4%)

Query: 810  QFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLS 868
            + +LS   +  +P ++ ++ + L +L L  NK+  + + +  L  L  L LS+N ++SL 
Sbjct: 104  RLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 162

Query: 869  ENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLD 925
            ++ L+   K+     R N L  +P   +   S+T L L  N+ + + + I NL  L  L 
Sbjct: 163  DS-LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 221

Query: 926  MSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPP 985
            +  N I+ LP     +  NL  L  +HNQ+    L ++    +++  L L HN+L ++P 
Sbjct: 222  IRENKIKQLPAEIG-ELCNLITLDVAHNQLE--HLPKEIGNCTQITNLDLQHNELLDLPD 278

Query: 986  EIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028
             IG L +L+ L + YN  L + P  + K S + +L L+  +++
Sbjct: 279  TIGNLSSLSRLGLRYN-RLSAIPRSLAKCSALEELNLENNNIS 320



 Score = 70.5 bits (171), Expect = 4e-11
 Identities = 86/317 (27%), Positives = 133/317 (41%), Gaps = 57/317 (17%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN------------------------- 791
            LK L  LDL  NK    PS + ++  +  L +  N                         
Sbjct: 168  LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227

Query: 792  -----DIGP---SVVLD-----------PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKL 832
                 +IG     + LD               C  +   +L +N+L  +P+ + + +  L
Sbjct: 228  KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGN-LSSL 286

Query: 833  EQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAM 891
             +L L  N++S I   L +   L+ LNL  N+IS+L E+ L +  K+ S +   N     
Sbjct: 287  SRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLY 346

Query: 892  PFLPPSM--TI--LKLSQNKFSCIPEAILNLPH-LRSLDMSSNDIQYLP-GPAHWKSLNL 945
            P   PS   TI  L +  N+ + IP  I +    L  L+M  N +  LP     W S  +
Sbjct: 347  PVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS--M 404

Query: 946  RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELR 1005
             EL  + NQ++   + E       +E L LS+N LK++P  +G L  L  LD+  N +L 
Sbjct: 405  VELNLATNQLT--KIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN-KLE 461

Query: 1006 SFPNEMGKLSKIWDLPL 1022
            S PNE+  L  +  L L
Sbjct: 462  SLPNEIAYLKDLQKLVL 478



 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 86/343 (25%), Positives = 150/343 (43%), Gaps = 82/343 (23%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANL-DVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
            L  LT L L+SNK  S P+   ++ C+ NL  ++ ++   + + D       L+  +L +
Sbjct: 122  LTQLTELYLYSNKLQSLPA---EVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRH 178

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSL------- 867
            N+L  +P ++   ++ L  L L  N+I+ +   ++ L +L +L++ +N I  L       
Sbjct: 179  NKLREIP-SVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGEL 237

Query: 868  --------SENFLEACPK------------------------------VESFSARMNFLA 889
                    + N LE  PK                              +     R N L+
Sbjct: 238  CNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLS 297

Query: 890  AMP---FLPPSMTILKLSQNKFSCIPEAIL-NLPHLRSLDMSSNDIQYLP--GPAHWK-- 941
            A+P       ++  L L  N  S +PE++L +L  L SL ++ N  Q  P  GP+ +   
Sbjct: 298  AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTI 357

Query: 942  -SLN-------------------LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981
             SLN                   L +L    NQ++ L L      W+ + +L+L+ N+L 
Sbjct: 358  YSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT--WTSMVELNLATNQLT 415

Query: 982  EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
            +IP ++  L +L  L +S NL L+  P+ +G L K+ +L L+E
Sbjct: 416  KIPEDVSGLVSLEVLILSNNL-LKKLPHGLGNLRKLRELDLEE 457



>gi|40788390|dbj|BAA74885.2|   KIAA0862 protein [Homo sapiens]
          Length = 584

 Score = 94.7 bits (234), Expect = 2e-18
 Identities = 83/327 (25%), Positives = 141/327 (43%), Gaps = 36/327 (11%)

Query: 760  LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLS 819
            +T+LDL  N+    P  +  +S ++ L +  N +  S +     KC  L++ NL  N +S
Sbjct: 265  ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENNNIS 322

Query: 820  FVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEACPK 877
             +PE+L   + KL  L L  N  ++  +  P +   +  LN+  N I+ +          
Sbjct: 323  TLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKV 382

Query: 878  VESFSARMNFLAAMPF--------------------LPP------SMTILKLSQNKFSCI 911
            +   + + N L ++P                     +P       S+ +L LS N    +
Sbjct: 383  LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 442

Query: 912  PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971
            P  + NL  LR LD+  N ++ LP    +   +L++L+ ++NQ++ L         + + 
Sbjct: 443  PHGLGNLRKLRELDLEENKLESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHL--TNLT 499

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDF 1031
             L L  N L  +P EIG LENL  L ++ N  L S P E+   SK+  + ++   L+   
Sbjct: 500  HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPLELALCSKLSIMSIENCPLSHLP 559

Query: 1032 KHIGCKAKDIIRFLQQRLKKAVPYNRM 1058
              I         F+ Q LK   PY  M
Sbjct: 560  PQIVAGGPS---FIIQFLKMQGPYRAM 583



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 62/223 (27%), Positives = 114/223 (51%), Gaps = 10/223 (4%)

Query: 810  QFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLS 868
            + +LS   +  +P ++ ++ + L +L L  NK+  + + +  L  L  L LS+N ++SL 
Sbjct: 106  RLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 164

Query: 869  ENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLD 925
            ++ L+   K+     R N L  +P   +   S+T L L  N+ + + + I NL  L  L 
Sbjct: 165  DS-LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 223

Query: 926  MSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPP 985
            +  N I+ LP     +  NL  L  +HNQ+    L ++    +++  L L HN+L ++P 
Sbjct: 224  IRENKIKQLPAEIG-ELCNLITLDVAHNQLE--HLPKEIGNCTQITNLDLQHNELLDLPD 280

Query: 986  EIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028
             IG L +L+ L + YN  L + P  + K S + +L L+  +++
Sbjct: 281  TIGNLSSLSRLGLRYN-RLSAIPRSLAKCSALEELNLENNNIS 322



 Score = 70.5 bits (171), Expect = 4e-11
 Identities = 86/317 (27%), Positives = 133/317 (41%), Gaps = 57/317 (17%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN------------------------- 791
            LK L  LDL  NK    PS + ++  +  L +  N                         
Sbjct: 170  LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 229

Query: 792  -----DIGP---SVVLD-----------PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKL 832
                 +IG     + LD               C  +   +L +N+L  +P+ + + +  L
Sbjct: 230  KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGN-LSSL 288

Query: 833  EQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAM 891
             +L L  N++S I   L +   L+ LNL  N+IS+L E+ L +  K+ S +   N     
Sbjct: 289  SRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLY 348

Query: 892  PFLPPSM--TI--LKLSQNKFSCIPEAILNLPH-LRSLDMSSNDIQYLP-GPAHWKSLNL 945
            P   PS   TI  L +  N+ + IP  I +    L  L+M  N +  LP     W S  +
Sbjct: 349  PVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTS--M 406

Query: 946  RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELR 1005
             EL  + NQ++   + E       +E L LS+N LK++P  +G L  L  LD+  N +L 
Sbjct: 407  VELNLATNQLT--KIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN-KLE 463

Query: 1006 SFPNEMGKLSKIWDLPL 1022
            S PNE+  L  +  L L
Sbjct: 464  SLPNEIAYLKDLQKLVL 480



 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 86/343 (25%), Positives = 150/343 (43%), Gaps = 82/343 (23%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANL-DVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
            L  LT L L+SNK  S P+   ++ C+ NL  ++ ++   + + D       L+  +L +
Sbjct: 124  LTQLTELYLYSNKLQSLPA---EVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRH 180

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSL------- 867
            N+L  +P ++   ++ L  L L  N+I+ +   ++ L +L +L++ +N I  L       
Sbjct: 181  NKLREIP-SVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGEL 239

Query: 868  --------SENFLEACPK------------------------------VESFSARMNFLA 889
                    + N LE  PK                              +     R N L+
Sbjct: 240  CNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLS 299

Query: 890  AMP---FLPPSMTILKLSQNKFSCIPEAIL-NLPHLRSLDMSSNDIQYLP--GPAHWK-- 941
            A+P       ++  L L  N  S +PE++L +L  L SL ++ N  Q  P  GP+ +   
Sbjct: 300  AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTI 359

Query: 942  -SLN-------------------LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981
             SLN                   L +L    NQ++ L L      W+ + +L+L+ N+L 
Sbjct: 360  YSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT--WTSMVELNLATNQLT 417

Query: 982  EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
            +IP ++  L +L  L +S NL L+  P+ +G L K+ +L L+E
Sbjct: 418  KIPEDVSGLVSLEVLILSNNL-LKKLPHGLGNLRKLRELDLEE 459



 Score = 33.1 bits (74), Expect = 6.4
 Identities = 32/120 (26%), Positives = 48/120 (40%), Gaps = 14/120 (11%)

Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
           L+ L  LDL  NK  S P+ +  +  +  L ++ N +  + +         L    L  N
Sbjct: 449 LRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQL--TTLPRGIGHLTNLTHLGLGEN 506

Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACP 876
            L+ +PE +   +E LE+L L  N             L  L L     S LS   +E CP
Sbjct: 507 LLTHLPEEI-GTLENLEELYLNDN-----------PNLHSLPLELALCSKLSIMSIENCP 554



>gi|55661684|emb|CAH72813.1|   soc-2 suppressor of clear homolog (C. elegans) [Homo sapiens]
          Length = 372

 Score = 93.6 bits (231), Expect = 4e-18
 Identities = 83/330 (25%), Positives = 141/330 (42%), Gaps = 36/330 (10%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            L  L+ L +  NK    P+ +  +S ++ L +  N +  S +     KC  L++ NL  N
Sbjct: 50   LSKLSMLSIRENKIKQLPAEIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENN 107

Query: 817  QLSFVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEA 874
             +S +PE+L   + KL  L L  N  ++  +  P +   +  LN+  N I+ +       
Sbjct: 108  NISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSR 167

Query: 875  CPKVESFSARMNFLAAMPF--------------------LPP------SMTILKLSQNKF 908
               +   + + N L ++P                     +P       S+ +L LS N  
Sbjct: 168  AKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 227

Query: 909  SCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968
              +P  + NL  LR LD+  N ++ LP    +   +L++L+ ++NQ++ L         +
Sbjct: 228  KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHL--T 284

Query: 969  RVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028
             +  L L  N L  +P EIG LENL  L ++ N  L S P E+   SK+  + ++   L+
Sbjct: 285  NLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 344

Query: 1029 FDFKHIGCKAKDIIRFLQQRLKKAVPYNRM 1058
                 I         F+ Q LK   PY  M
Sbjct: 345  HLPPQIVAGGPS---FIIQFLKMQGPYRAM 371



 Score = 85.9 bits (211), Expect = 8e-16
 Identities = 88/322 (27%), Positives = 136/322 (42%), Gaps = 60/322 (18%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP--------------------- 795
            LK L  LDL  NK    PS + ++  +  L +  N I                       
Sbjct: 4    LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 63

Query: 796  -----------------------SVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKL 832
                                   S +     KC  L++ NL  N +S +PE+L   + KL
Sbjct: 64   KQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKL 123

Query: 833  EQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAA 890
              L L  N  ++  +  P +   +  LN+  N I+ +          +   + + N L +
Sbjct: 124  NSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTS 183

Query: 891  MPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP-GPAHWKSLNLR 946
            +P       SM  L L+ N+ + IPE +  L  L  L +S+N ++ LP G  + +   LR
Sbjct: 184  LPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLR--KLR 241

Query: 947  ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006
            EL    N++  L  +E AYL   ++KL L++N+L  +P  IG L NLT L +  NL L  
Sbjct: 242  ELDLEENKLESLP-NEIAYL-KDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENL-LTH 298

Query: 1007 FPNEMGKLSKIWDLPLDELHLN 1028
             P E+G L       L+EL+LN
Sbjct: 299  LPEEIGTLEN-----LEELYLN 315



 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 76/347 (21%), Positives = 147/347 (42%), Gaps = 59/347 (17%)

Query: 643 DKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSM 702
           +K   L  +    S+L+R+ +RY   SA+    A  S     E++  + +  + +P+S +
Sbjct: 61  NKIKQLPAEIGNLSSLSRLGLRYNRLSAIPRSLAKCS---ALEELNLENNNISTLPESLL 117

Query: 703 DSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTH 762
            S+                    K NS++         L R    L          ++  
Sbjct: 118 SSLV-------------------KLNSLT---------LARNCFQLYPVGGPSQFSTIYS 149

Query: 763 LDLHSNKFTSFP-SYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFV 821
           L++  N+    P     +   ++ L++  N +  S+ LD      ++ + NL+ NQL+ +
Sbjct: 150 LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL-TSLPLD-FGTWTSMVELNLATNQLTKI 207

Query: 822 PENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVES 880
           PE+++ +V  LE LIL  N +  +   L  L++L+ L+L +N              K+ES
Sbjct: 208 PEDVSGLV-SLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN--------------KLES 252

Query: 881 FSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHW 940
               + +L         +  L L+ N+ + +P  I +L +L  L +  N + +LP     
Sbjct: 253 LPNEIAYL-------KDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGT 305

Query: 941 KSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEI 987
              NL EL  + N  ++  L  +  L S++  + + +  L  +PP+I
Sbjct: 306 LE-NLEELYLNDNP-NLHSLPFELALCSKLSIMSIENCPLSHLPPQI 350



 Score = 38.5 bits (88), Expect = 0.15
 Identities = 41/161 (25%), Positives = 71/161 (44%), Gaps = 7/161 (4%)

Query: 872  LEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSS 928
            L+   K+     R N L  +P   +   S+T L L  N+ + + + I NL  L  L +  
Sbjct: 1    LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 60

Query: 929  NDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPE-I 987
            N I+ LP      S +L  L   +N++S +  S      S +E+L+L +N +  +P   +
Sbjct: 61   NKIKQLPAEIGNLS-SLSRLGLRYNRLSAIPRS--LAKCSALEELNLENNNISTLPESLL 117

Query: 988  GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028
              L  L SL ++ N           + S I+ L ++   +N
Sbjct: 118  SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRIN 158



>gi|32812252|gb|AAP88017.1|   CRIB1 [Homo sapiens]
 gi|45827729|ref|NP_056171.2|   scribble isoform b [Homo sapiens]
 gi|50400856|sp|Q14160|LAP4_HUMAN   LAP4 protein (Scribble homolog protein) (hScrib)
 gi|20521832|dbj|BAA09768.3|   KIAA0147 protein [Homo sapiens]
          Length = 1630

 Score = 88.2 bits (217), Expect = 2e-16
 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815
            L +L  L L  N+    P  +     +  LDVSRNDI     +  ++K C  L+  + S 
Sbjct: 58   LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 114

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N LS +P+  T  +  L  L L    +  +   +  L  L  L L +N + SL  + L  
Sbjct: 115  NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172

Query: 875  CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
              K+E      N L  +P      P++  L L +N+ S +P  + NL  L  LD+S N +
Sbjct: 173  LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
            + LP       L L +LL S N +    L +      ++  L +  N+L E+   IG  E
Sbjct: 233  EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289

Query: 992  NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050
            NL+ L ++ NL L + P  +GKL+K+ +L +D  HL      I GC A  ++     RL 
Sbjct: 290  NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348

Query: 1051 KAVP 1054
               P
Sbjct: 349  VLPP 352



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 77/268 (28%), Positives = 128/268 (47%), Gaps = 8/268 (2%)

Query: 801  PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNL 859
            P  +   L++  LS N++  +P  + + ++ +E L +  N I  I   ++  K L+I + 
Sbjct: 54   PFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADF 112

Query: 860  SKNHISSLSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
            S N +S L + F  L +   +      +  L        ++  L+L +N    +P ++  
Sbjct: 113  SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172

Query: 918  LPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSH 977
            L  L  LD+  ND++ LP        NLREL    NQ+S L   E   L  R+  L +S 
Sbjct: 173  LVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSE 229

Query: 978  NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK 1037
            N+L+E+P E+G L  LT L +S NL LR  P+ +G+L ++  L +D+  L    + IG  
Sbjct: 230  NRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDC 288

Query: 1038 AKDIIRFLQQRLKKAVPYNRMKLMIVGN 1065
                   L + L  A+P +  KL  + N
Sbjct: 289  ENLSELILTENLLMALPRSLGKLTKLTN 316



 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 70/234 (29%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            L  VPE +      LE+L+L+ N++  +  P  RL  L+ L LS N I  L         
Sbjct: 24   LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 877  KVESFSARMNFLAAMPFLPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSND 930
             VE   +R +    +P +P S+   K       S N  S +P+    L  L  L ++   
Sbjct: 84   LVELDVSRND----IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139

Query: 931  IQYLPGP----AHWKSLNLRELLFSHNQISI--------LDLS--------EKAYLWSRV 970
            +Q LPG     A+  +L LRE L      S+        LDL         +       +
Sbjct: 140  LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199

Query: 971  EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
             +L L  N+L  +PPE+G L  L  LDVS N  L   P E+G L  + DL L +
Sbjct: 200  RELWLDRNQLSALPPELGNLRRLVCLDVSEN-RLEELPAELGGLVLLTDLLLSQ 252



 Score = 57.0 bits (136), Expect = 4e-07
 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815
            L+SL HL L+     + P  +  ++ +  L++  N +      L   VK   L+Q +L  
Sbjct: 127  LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 183

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N L  +P+ L   +  L +L L+ N++S +   L  L+ L  L++S+N +  L    L  
Sbjct: 184  NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 241

Query: 875  CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
               +       N L  +P        ++ILK+ QN+   + EAI +  +L  L ++ N +
Sbjct: 242  LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
              LP     K   L  L    N +  L       +   V  L L  N+L  +PPE+    
Sbjct: 302  MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 358

Query: 992  NLTSLDVSYNLELRSFP 1008
             L  LDV+ N  L+S P
Sbjct: 359  ELHVLDVAGN-RLQSLP 374



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 25/167 (14%)

Query: 910  CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969
            CIP    N  H+ S+D     +Q +P   +  S +L ELL   NQ+   +L +  +    
Sbjct: 4    CIPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLR--ELPKPFFRLLN 60

Query: 970  VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN--------------LELRSF-------- 1007
            + KL LS N+++ +PPE+     L  LDVS N              LE+  F        
Sbjct: 61   LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120

Query: 1008 PNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054
            P+   +L  +  L L+++ L      +G  A  +   L++ L K++P
Sbjct: 121  PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167



>gi|32812254|gb|AAP88018.1|   SCRIB1 variant N1 [Homo sapiens]
          Length = 1601

 Score = 88.2 bits (217), Expect = 2e-16
 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815
            L +L  L L  N+    P  +     +  LDVSRNDI     +  ++K C  L+  + S 
Sbjct: 29   LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 85

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N LS +P+  T  +  L  L L    +  +   +  L  L  L L +N + SL  + L  
Sbjct: 86   NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 143

Query: 875  CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
              K+E      N L  +P      P++  L L +N+ S +P  + NL  L  LD+S N +
Sbjct: 144  LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 203

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
            + LP       L L +LL S N +    L +      ++  L +  N+L E+   IG  E
Sbjct: 204  EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 260

Query: 992  NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050
            NL+ L ++ NL L + P  +GKL+K+ +L +D  HL      I GC A  ++     RL 
Sbjct: 261  NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 319

Query: 1051 KAVP 1054
               P
Sbjct: 320  VLPP 323



 Score = 73.9 bits (180), Expect = 3e-12
 Identities = 76/261 (29%), Positives = 126/261 (48%), Gaps = 8/261 (3%)

Query: 808  LKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHISS 866
            L++  LS N++  +P  + + ++ +E L +  N I  I   ++  K L+I + S N +S 
Sbjct: 32   LRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADFSGNPLSR 90

Query: 867  LSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSL 924
            L + F  L +   +      +  L        ++  L+L +N    +P ++  L  L  L
Sbjct: 91   LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 150

Query: 925  DMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIP 984
            D+  ND++ LP        NLREL    NQ+S L   E   L  R+  L +S N+L+E+P
Sbjct: 151  DLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSENRLEELP 207

Query: 985  PEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRF 1044
             E+G L  LT L +S NL LR  P+ +G+L ++  L +D+  L    + IG         
Sbjct: 208  AELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELI 266

Query: 1045 LQQRLKKAVPYNRMKLMIVGN 1065
            L + L  A+P +  KL  + N
Sbjct: 267  LTENLLMALPRSLGKLTKLTN 287



 Score = 57.0 bits (136), Expect = 4e-07
 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815
            L+SL HL L+     + P  +  ++ +  L++  N +      L   VK   L+Q +L  
Sbjct: 98   LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 154

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N L  +P+ L   +  L +L L+ N++S +   L  L+ L  L++S+N +  L    L  
Sbjct: 155  NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 212

Query: 875  CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
               +       N L  +P        ++ILK+ QN+   + EAI +  +L  L ++ N +
Sbjct: 213  LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 272

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
              LP     K   L  L    N +  L       +   V  L L  N+L  +PPE+    
Sbjct: 273  MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 329

Query: 992  NLTSLDVSYNLELRSFP 1008
             L  LDV+ N  L+S P
Sbjct: 330  ELHVLDVAGN-RLQSLP 345



>gi|45827731|ref|NP_874365.2|   scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 88.2 bits (217), Expect = 2e-16
 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815
            L +L  L L  N+    P  +     +  LDVSRNDI     +  ++K C  L+  + S 
Sbjct: 58   LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 114

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N LS +P+  T  +  L  L L    +  +   +  L  L  L L +N + SL  + L  
Sbjct: 115  NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172

Query: 875  CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
              K+E      N L  +P      P++  L L +N+ S +P  + NL  L  LD+S N +
Sbjct: 173  LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
            + LP       L L +LL S N +    L +      ++  L +  N+L E+   IG  E
Sbjct: 233  EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289

Query: 992  NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050
            NL+ L ++ NL L + P  +GKL+K+ +L +D  HL      I GC A  ++     RL 
Sbjct: 290  NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348

Query: 1051 KAVP 1054
               P
Sbjct: 349  VLPP 352



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 77/268 (28%), Positives = 128/268 (47%), Gaps = 8/268 (2%)

Query: 801  PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNL 859
            P  +   L++  LS N++  +P  + + ++ +E L +  N I  I   ++  K L+I + 
Sbjct: 54   PFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADF 112

Query: 860  SKNHISSLSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
            S N +S L + F  L +   +      +  L        ++  L+L +N    +P ++  
Sbjct: 113  SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172

Query: 918  LPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSH 977
            L  L  LD+  ND++ LP        NLREL    NQ+S L   E   L  R+  L +S 
Sbjct: 173  LVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSE 229

Query: 978  NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK 1037
            N+L+E+P E+G L  LT L +S NL LR  P+ +G+L ++  L +D+  L    + IG  
Sbjct: 230  NRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDC 288

Query: 1038 AKDIIRFLQQRLKKAVPYNRMKLMIVGN 1065
                   L + L  A+P +  KL  + N
Sbjct: 289  ENLSELILTENLLMALPRSLGKLTKLTN 316



 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 70/234 (29%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            L  VPE +      LE+L+L+ N++  +  P  RL  L+ L LS N I  L         
Sbjct: 24   LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 877  KVESFSARMNFLAAMPFLPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSND 930
             VE   +R +    +P +P S+   K       S N  S +P+    L  L  L ++   
Sbjct: 84   LVELDVSRND----IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139

Query: 931  IQYLPGP----AHWKSLNLRELLFSHNQISI--------LDLS--------EKAYLWSRV 970
            +Q LPG     A+  +L LRE L      S+        LDL         +       +
Sbjct: 140  LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199

Query: 971  EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
             +L L  N+L  +PPE+G L  L  LDVS N  L   P E+G L  + DL L +
Sbjct: 200  RELWLDRNQLSALPPELGNLRRLVCLDVSEN-RLEELPAELGGLVLLTDLLLSQ 252



 Score = 57.0 bits (136), Expect = 4e-07
 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815
            L+SL HL L+     + P  +  ++ +  L++  N +      L   VK   L+Q +L  
Sbjct: 127  LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 183

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N L  +P+ L   +  L +L L+ N++S +   L  L+ L  L++S+N +  L    L  
Sbjct: 184  NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 241

Query: 875  CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
               +       N L  +P        ++ILK+ QN+   + EAI +  +L  L ++ N +
Sbjct: 242  LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
              LP     K   L  L    N +  L       +   V  L L  N+L  +PPE+    
Sbjct: 302  MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 358

Query: 992  NLTSLDVSYNLELRSFP 1008
             L  LDV+ N  L+S P
Sbjct: 359  ELHVLDVAGN-RLQSLP 374



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 25/167 (14%)

Query: 910  CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969
            CIP    N  H+ S+D     +Q +P   +  S +L ELL   NQ+   +L +  +    
Sbjct: 4    CIPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLR--ELPKPFFRLLN 60

Query: 970  VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN--------------LELRSF-------- 1007
            + KL LS N+++ +PPE+     L  LDVS N              LE+  F        
Sbjct: 61   LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120

Query: 1008 PNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054
            P+   +L  +  L L+++ L      +G  A  +   L++ L K++P
Sbjct: 121  PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167



>gi|18032008|gb|AAL38976.1|   scribble [Homo sapiens]
          Length = 1630

 Score = 88.2 bits (217), Expect = 2e-16
 Identities = 90/304 (29%), Positives = 138/304 (45%), Gaps = 15/304 (4%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVK-CPTLKQFNLSY 815
            L +L  L L  N+    P  +     +  LDVSRNDI     +  ++K C  L+  + S 
Sbjct: 58   LLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE---IPESIKFCKALEIADFSG 114

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N LS +P+  T  +  L  L L    +  +   +  L  L  L L +N + SL  + L  
Sbjct: 115  NPLSRLPDGFTQ-LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS-LSF 172

Query: 875  CPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
              K+E      N L  +P      P++  L L +N+ S +P  + NL  L  LD+S N +
Sbjct: 173  LVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRL 232

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
            + LP       L L +LL S N +    L +      ++  L +  N+L E+   IG  E
Sbjct: 233  EELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289

Query: 992  NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHI-GCKAKDIIRFLQQRLK 1050
            NL+ L ++ NL L + P  +GKL+K+ +L +D  HL      I GC A  ++     RL 
Sbjct: 290  NLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348

Query: 1051 KAVP 1054
               P
Sbjct: 349  VLPP 352



 Score = 74.7 bits (182), Expect = 2e-12
 Identities = 77/268 (28%), Positives = 128/268 (47%), Gaps = 8/268 (2%)

Query: 801  PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNL 859
            P  +   L++  LS N++  +P  + + ++ +E L +  N I  I   ++  K L+I + 
Sbjct: 54   PFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVE-LDVSRNDIPEIPESIKFCKALEIADF 112

Query: 860  SKNHISSLSENF--LEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
            S N +S L + F  L +   +      +  L        ++  L+L +N    +P ++  
Sbjct: 113  SGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF 172

Query: 918  LPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSH 977
            L  L  LD+  ND++ LP        NLREL    NQ+S L   E   L  R+  L +S 
Sbjct: 173  LVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVCLDVSE 229

Query: 978  NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK 1037
            N+L+E+P E+G L  LT L +S NL LR  P+ +G+L ++  L +D+  L    + IG  
Sbjct: 230  NRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDC 288

Query: 1038 AKDIIRFLQQRLKKAVPYNRMKLMIVGN 1065
                   L + L  A+P +  KL  + N
Sbjct: 289  ENLSELILTENLLMALPRSLGKLTKLTN 316



 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 70/234 (29%), Positives = 100/234 (42%), Gaps = 32/234 (13%)

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            L  VPE +      LE+L+L+ N++  +  P  RL  L+ L LS N I  L         
Sbjct: 24   LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 877  KVESFSARMNFLAAMPFLPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSND 930
             VE   +R +    +P +P S+   K       S N  S +P+    L  L  L ++   
Sbjct: 84   LVELDVSRND----IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVS 139

Query: 931  IQYLPGP----AHWKSLNLRELLFSHNQISI--------LDLS--------EKAYLWSRV 970
            +Q LPG     A+  +L LRE L      S+        LDL         +       +
Sbjct: 140  LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNL 199

Query: 971  EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
             +L L  N+L  +PPE+G L  L  LDVS N  L   P E+G L  + DL L +
Sbjct: 200  RELWLDRNQLSALPPELGNLRRLVCLDVSEN-RLEELPAELGGLVLLTDLLLSQ 252



 Score = 57.0 bits (136), Expect = 4e-07
 Identities = 69/257 (26%), Positives = 113/257 (43%), Gaps = 14/257 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSY 815
            L+SL HL L+     + P  +  ++ +  L++  N +      L   VK   L+Q +L  
Sbjct: 127  LRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGG 183

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N L  +P+ L   +  L +L L+ N++S +   L  L+ L  L++S+N +  L    L  
Sbjct: 184  NDLEVLPDTL-GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGG 241

Query: 875  CPKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDI 931
               +       N L  +P        ++ILK+ QN+   + EAI +  +L  L ++ N +
Sbjct: 242  LVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLL 301

Query: 932  QYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
              LP     K   L  L    N +  L       +   V  L L  N+L  +PPE+    
Sbjct: 302  MALPRSLG-KLTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTT 358

Query: 992  NLTSLDVSYNLELRSFP 1008
             L  LDV+ N  L+S P
Sbjct: 359  ELHVLDVAGN-RLQSLP 374



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 25/167 (14%)

Query: 910  CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969
            CIP    N  H+ S+D     +Q +P   +  S +L ELL   NQ+   +L +  +    
Sbjct: 4    CIPLWRCNR-HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLR--ELPKPFFRLLN 60

Query: 970  VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN--------------LELRSF-------- 1007
            + KL LS N+++ +PPE+     L  LDVS N              LE+  F        
Sbjct: 61   LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120

Query: 1008 PNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1054
            P+   +L  +  L L+++ L      +G  A  +   L++ L K++P
Sbjct: 121  PDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLP 167



>gi|56205237|emb|CAI22332.1|   novel protein [Homo sapiens]
 gi|10434638|dbj|BAB14326.1|   unnamed protein product [Homo sapiens]
 gi|21361633|ref|NP_060238.3|   hypothetical protein FLJ20331 [Homo sapiens]
 gi|14250313|gb|AAH08586.1|   Hypothetical protein FLJ20331 [Homo sapiens]
          Length = 602

 Score = 85.9 bits (211), Expect = 8e-16
 Identities = 84/304 (27%), Positives = 147/304 (48%), Gaps = 39/304 (12%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            L +LT LD+H N+ TS PS + ++                           L++ N+S+N
Sbjct: 104  LPALTVLDIHDNQLTSLPSAIRELE-------------------------NLQKLNVSHN 138

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875
            +L  +PE +T++   L+ L L+ N+++ I     +L  L+ L+LS NH++++  +F    
Sbjct: 139  KLKILPEEITNL-RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLS 197

Query: 876  PKVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQ 932
              V   +   N L ++P     M  LK    + N    IP  +  +  L  L +  N ++
Sbjct: 198  SLVR-LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 256

Query: 933  YLPGPAHWKSLNL-RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
            +LP    + S +L +EL    NQI +L+     +L S +  L L  NKLK +P EI  L 
Sbjct: 257  FLP---EFPSCSLLKELHVGENQIEMLEAEHLKHLNS-ILVLDLRDNKLKSVPDEIILLR 312

Query: 992  NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK-AKDIIRFLQQRLK 1050
            +L  LD+S N ++ S P  +G L  +  L L+   L    + I  K  ++++++L+ ++K
Sbjct: 313  SLERLDLSNN-DISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIK 370

Query: 1051 KAVP 1054
               P
Sbjct: 371  DDGP 374



 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 7/200 (3%)

Query: 821  VPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHIS-SLSENFLEACP--K 877
            VP+ L     K  QL L G  +S +   +    + I   +  ++S   +E + E     K
Sbjct: 27   VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTK 86

Query: 878  VESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGP 937
            +   + ++  L     L P++T+L +  N+ + +P AI  L +L+ L++S N ++ LP  
Sbjct: 87   LIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEE 146

Query: 938  AHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLD 997
                  NL+ L   HN+++   +SE     S +E L LS+N L  +P     L +L  L+
Sbjct: 147  I-TNLRNLKCLYLQHNELTC--ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203

Query: 998  VSYNLELRSFPNEMGKLSKI 1017
            +S N EL+S P E+ ++ ++
Sbjct: 204  LSSN-ELKSLPAEINRMKRL 222



 Score = 63.9 bits (154), Expect = 3e-09
 Identities = 73/263 (27%), Positives = 117/263 (44%), Gaps = 34/263 (12%)

Query: 771  TSFPSYLLKMSCIAN-LDVSRNDIG--PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTD 827
            TS P  LLK +  +  L++S  ++   P  V    V  P     NLS+       E  TD
Sbjct: 25   TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQ-TD 83

Query: 828  VVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMN 886
                L +LI+  NK+  +   LRL   L +L++  N ++SL     E             
Sbjct: 84   ----LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIREL------------ 127

Query: 887  FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946
                      ++  L +S NK   +PE I NL +L+ L +  N++  +       S NL 
Sbjct: 128  ---------ENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLE 177

Query: 947  ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006
            +L  S+N ++ +  S  +   S + +L+LS N+LK +P EI  ++ L  LD + NL L +
Sbjct: 178  DLDLSNNHLTTVPASFSSL--SSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNL-LET 234

Query: 1007 FPNEMGKLSKIWDLPLDELHLNF 1029
             P E+  +  +  L L    L F
Sbjct: 235  IPPELAGMESLELLYLRRNKLRF 257



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 49/193 (25%), Positives = 88/193 (45%), Gaps = 25/193 (12%)

Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISS 866
           TLK  + S  Q + +P+ + D V+         N ++ I            N SKN +  
Sbjct: 400 TLKILDYSDKQATLIPDEVFDAVKS--------NIVTSI------------NFSKNQLCE 439

Query: 867 LSENFLEACPKVESFSARMN---FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS 923
           + +  +E    V       N   F++    +   +T L L  N  + +PE + +L  L++
Sbjct: 440 IPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQT 499

Query: 924 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI 983
           +++S N  + LP    ++   L  +L S+NQ+  +D  +K  +   +  L L +N L +I
Sbjct: 500 INLSFNRFKMLP-EVLYRIFTLETILISNNQVGSVD-PQKMKMMENLTTLDLQNNDLLQI 557

Query: 984 PPEIGCLENLTSL 996
           PPE+G   NL +L
Sbjct: 558 PPELGNCVNLRTL 570



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 73/290 (25%), Positives = 126/290 (43%), Gaps = 27/290 (9%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG--PSVVLDPTVKCPTLKQFNLS 814
            L S+  LDL  NK  S P  ++ +  +  LD+S NDI   P  + +  +K   L+   L 
Sbjct: 288  LNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLR 347

Query: 815  YNQLSFVPENLTDVVEKLEQLILEGNKISG---------ICSPLRLK-----ELKILNLS 860
              +   + +   +V++ L   I +               + S  R+       LKIL+ S
Sbjct: 348  TIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYS 407

Query: 861  KNHISSLSENFLEACPK--VESFSARMNFLAAMPF----LPPSMTILKLSQNKFSCIPEA 914
                + + +   +A     V S +   N L  +P     L   ++ + LS NK S I   
Sbjct: 408  DKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE 467

Query: 915  ILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLH 974
            +  L  L  LD+ +N +  LP       + L+ +  S N+  +L   E  Y    +E + 
Sbjct: 468  LCVLQKLTFLDLRNNFLNSLPEEME-SLVRLQTINLSFNRFKMLP--EVLYRIFTLETIL 524

Query: 975  LSHNKLKEIPPE-IGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLD 1023
            +S+N++  + P+ +  +ENLT+LD+  N +L   P E+G    +  L LD
Sbjct: 525  ISNNQVGSVDPQKMKMMENLTTLDLQNN-DLLQIPPELGNCVNLRTLLLD 573



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 73/289 (25%), Positives = 114/289 (39%), Gaps = 28/289 (9%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            +K L HLD +SN   + P  L  M  +  L + RN +     L     C  LK+ ++  N
Sbjct: 219  MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR---FLPEFPSCSLLKELHVGEN 275

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875
            Q+  +       +  +  L L  NK+  +   +  L+ L+ L+LS N ISSL  +     
Sbjct: 276  QIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH 335

Query: 876  PKVESFSAR-MNFLAAMPFLPPSMTILKLSQNKFS--------CIPEAILNLPH------ 920
             K  +     +  +        +  +LK  ++K             E  + LP       
Sbjct: 336  LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNI 395

Query: 921  -----LRSLDMSSNDIQYLPGPAH--WKSLNLRELLFSHNQISILDLSEKAYLWSRVEKL 973
                 L+ LD S      +P       KS  +  + FS NQ+  +       L   V  +
Sbjct: 396  HAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIP-KRMVELKEMVSDV 454

Query: 974  HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
             LS NKL  I  E+  L+ LT LD+  N  L S P EM  L ++  + L
Sbjct: 455  DLSFNKLSFISLELCVLQKLTFLDLRNNF-LNSLPEEMESLVRLQTINL 502



 Score = 57.0 bits (136), Expect = 4e-07
 Identities = 45/168 (26%), Positives = 85/168 (50%), Gaps = 8/168 (4%)

Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKE 853
           P  V D  VK   +   N S NQL  +P+ + ++ E +  + L  NK+S I   L  L++
Sbjct: 415 PDEVFD-AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQK 473

Query: 854 LKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSC 910
           L  L+L  N ++SL E  +E+  ++++ +   N    +P   +   ++  + +S N+   
Sbjct: 474 LTFLDLRNNFLNSLPEE-MESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532

Query: 911 I-PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISI 957
           + P+ +  + +L +LD+ +ND+  +P P     +NLR LL   N   +
Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIP-PELGNCVNLRTLLLDGNPFRV 579



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 53/193 (27%), Positives = 78/193 (40%), Gaps = 49/193 (25%)

Query: 756 TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
           +L SL  L+L SN+  S P+ + +M  + +LD +                          
Sbjct: 195 SLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNS------------------------- 229

Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875
           N L  +P  L   +E LE L L  NK+  +        LK L++ +N I  L    L+  
Sbjct: 230 NLLETIPPELAG-MESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLK-- 286

Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935
                    +N          S+ +L L  NK   +P+ I+ L  L  LD+S+NDI  LP
Sbjct: 287 --------HLN----------SILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 328

Query: 936 ---GPAHWKSLNL 945
              G  H K L L
Sbjct: 329 YSLGNLHLKFLAL 341



 Score = 35.4 bits (80), Expect = 1.3
 Identities = 61/252 (24%), Positives = 103/252 (40%), Gaps = 23/252 (9%)

Query: 608 LLLRRLA-LDVANNSICLGGFCIGKVEPSWLG----PLFPDKTSNLRKQTNIASTLARMV 662
           +LLR L  LD++NN I    + +G +   +L     PL   +   + K T       R  
Sbjct: 309 ILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 368

Query: 663 IR----YQMKSAVEEGTASGSDG--NFSEDVLSKFDEW-----TFIPDSSMDSVFAQSDD 711
           I+     Q +SA E      S+   N    +  K  ++     T IPD   D+V  +S+ 
Sbjct: 369 IKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAV--KSNI 426

Query: 712 LDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL-TLKSLTHLDLHSNKF 770
           + S     + L +     + + E   D  L      L   S  L  L+ LT LDL +N  
Sbjct: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLS--FNKLSFISLELCVLQKLTFLDLRNNFL 484

Query: 771 TSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVE 830
            S P  +  +  +  +++S N     ++ +   +  TL+   +S NQ+  V      ++E
Sbjct: 485 NSLPEEMESLVRLQTINLSFNRF--KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMME 542

Query: 831 KLEQLILEGNKI 842
            L  L L+ N +
Sbjct: 543 NLTTLDLQNNDL 554



>gi|32425389|gb|AAH03407.2|   FLJ20331 protein [Homo sapiens]
          Length = 581

 Score = 85.9 bits (211), Expect = 8e-16
 Identities = 84/304 (27%), Positives = 147/304 (48%), Gaps = 39/304 (12%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            L +LT LD+H N+ TS PS + ++                           L++ N+S+N
Sbjct: 83   LPALTVLDIHDNQLTSLPSAIRELE-------------------------NLQKLNVSHN 117

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875
            +L  +PE +T++   L+ L L+ N+++ I     +L  L+ L+LS NH++++  +F    
Sbjct: 118  KLKILPEEITNL-RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLS 176

Query: 876  PKVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQ 932
              V   +   N L ++P     M  LK    + N    IP  +  +  L  L +  N ++
Sbjct: 177  SLVR-LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 235

Query: 933  YLPGPAHWKSLNL-RELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLE 991
            +LP    + S +L +EL    NQI +L+     +L S +  L L  NKLK +P EI  L 
Sbjct: 236  FLP---EFPSCSLLKELHVGENQIEMLEAEHLKHLNS-ILVLDLRDNKLKSVPDEIILLR 291

Query: 992  NLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK-AKDIIRFLQQRLK 1050
            +L  LD+S N ++ S P  +G L  +  L L+   L    + I  K  ++++++L+ ++K
Sbjct: 292  SLERLDLSNN-DISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIK 349

Query: 1051 KAVP 1054
               P
Sbjct: 350  DDGP 353



 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 7/200 (3%)

Query: 821  VPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHIS-SLSENFLEACP--K 877
            VP+ L     K  QL L G  +S +   +    + I   +  ++S   +E + E     K
Sbjct: 6    VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTK 65

Query: 878  VESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGP 937
            +   + ++  L     L P++T+L +  N+ + +P AI  L +L+ L++S N ++ LP  
Sbjct: 66   LIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEE 125

Query: 938  AHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLD 997
                  NL+ L   HN+++   +SE     S +E L LS+N L  +P     L +L  L+
Sbjct: 126  I-TNLRNLKCLYLQHNELTC--ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 182

Query: 998  VSYNLELRSFPNEMGKLSKI 1017
            +S N EL+S P E+ ++ ++
Sbjct: 183  LSSN-ELKSLPAEINRMKRL 201



 Score = 63.9 bits (154), Expect = 3e-09
 Identities = 73/263 (27%), Positives = 117/263 (44%), Gaps = 34/263 (12%)

Query: 771  TSFPSYLLKMSCIAN-LDVSRNDIG--PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTD 827
            TS P  LLK +  +  L++S  ++   P  V    V  P     NLS+       E  TD
Sbjct: 4    TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQ-TD 62

Query: 828  VVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMN 886
                L +LI+  NK+  +   LRL   L +L++  N ++SL     E             
Sbjct: 63   ----LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIREL------------ 106

Query: 887  FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLR 946
                      ++  L +S NK   +PE I NL +L+ L +  N++  +       S NL 
Sbjct: 107  ---------ENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLE 156

Query: 947  ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006
            +L  S+N ++ +  S  +   S + +L+LS N+LK +P EI  ++ L  LD + NL L +
Sbjct: 157  DLDLSNNHLTTVPASFSSL--SSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNL-LET 213

Query: 1007 FPNEMGKLSKIWDLPLDELHLNF 1029
             P E+  +  +  L L    L F
Sbjct: 214  IPPELAGMESLELLYLRRNKLRF 236



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 49/193 (25%), Positives = 88/193 (45%), Gaps = 25/193 (12%)

Query: 807 TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISS 866
           TLK  + S  Q + +P+ + D V+         N ++ I            N SKN +  
Sbjct: 379 TLKILDYSDKQATLIPDEVFDAVKS--------NIVTSI------------NFSKNQLCE 418

Query: 867 LSENFLEACPKVESFSARMN---FLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS 923
           + +  +E    V       N   F++    +   +T L L  N  + +PE + +L  L++
Sbjct: 419 IPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQT 478

Query: 924 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI 983
           +++S N  + LP    ++   L  +L S+NQ+  +D  +K  +   +  L L +N L +I
Sbjct: 479 INLSFNRFKMLP-EVLYRIFTLETILISNNQVGSVD-PQKMKMMENLTTLDLQNNDLLQI 536

Query: 984 PPEIGCLENLTSL 996
           PPE+G   NL +L
Sbjct: 537 PPELGNCVNLRTL 549



 Score = 58.5 bits (140), Expect = 1e-07
 Identities = 73/290 (25%), Positives = 126/290 (43%), Gaps = 27/290 (9%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG--PSVVLDPTVKCPTLKQFNLS 814
            L S+  LDL  NK  S P  ++ +  +  LD+S NDI   P  + +  +K   L+   L 
Sbjct: 267  LNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLR 326

Query: 815  YNQLSFVPENLTDVVEKLEQLILEGNKISG---------ICSPLRLK-----ELKILNLS 860
              +   + +   +V++ L   I +               + S  R+       LKIL+ S
Sbjct: 327  TIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYS 386

Query: 861  KNHISSLSENFLEACPK--VESFSARMNFLAAMPF----LPPSMTILKLSQNKFSCIPEA 914
                + + +   +A     V S +   N L  +P     L   ++ + LS NK S I   
Sbjct: 387  DKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE 446

Query: 915  ILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLH 974
            +  L  L  LD+ +N +  LP       + L+ +  S N+  +L   E  Y    +E + 
Sbjct: 447  LCVLQKLTFLDLRNNFLNSLPEEME-SLVRLQTINLSFNRFKMLP--EVLYRIFTLETIL 503

Query: 975  LSHNKLKEIPPE-IGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLD 1023
            +S+N++  + P+ +  +ENLT+LD+  N +L   P E+G    +  L LD
Sbjct: 504  ISNNQVGSVDPQKMKMMENLTTLDLQNN-DLLQIPPELGNCVNLRTLLLD 552



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 73/289 (25%), Positives = 114/289 (39%), Gaps = 28/289 (9%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            +K L HLD +SN   + P  L  M  +  L + RN +     L     C  LK+ ++  N
Sbjct: 198  MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR---FLPEFPSCSLLKELHVGEN 254

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875
            Q+  +       +  +  L L  NK+  +   +  L+ L+ L+LS N ISSL  +     
Sbjct: 255  QIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH 314

Query: 876  PKVESFSAR-MNFLAAMPFLPPSMTILKLSQNKFS--------CIPEAILNLPH------ 920
             K  +     +  +        +  +LK  ++K             E  + LP       
Sbjct: 315  LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNI 374

Query: 921  -----LRSLDMSSNDIQYLPGPAH--WKSLNLRELLFSHNQISILDLSEKAYLWSRVEKL 973
                 L+ LD S      +P       KS  +  + FS NQ+  +       L   V  +
Sbjct: 375  HAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIP-KRMVELKEMVSDV 433

Query: 974  HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
             LS NKL  I  E+  L+ LT LD+  N  L S P EM  L ++  + L
Sbjct: 434  DLSFNKLSFISLELCVLQKLTFLDLRNNF-LNSLPEEMESLVRLQTINL 481



 Score = 57.0 bits (136), Expect = 4e-07
 Identities = 45/168 (26%), Positives = 85/168 (50%), Gaps = 8/168 (4%)

Query: 795 PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKE 853
           P  V D  VK   +   N S NQL  +P+ + ++ E +  + L  NK+S I   L  L++
Sbjct: 394 PDEVFD-AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQK 452

Query: 854 LKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSC 910
           L  L+L  N ++SL E  +E+  ++++ +   N    +P   +   ++  + +S N+   
Sbjct: 453 LTFLDLRNNFLNSLPEE-MESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 511

Query: 911 I-PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISI 957
           + P+ +  + +L +LD+ +ND+  +P P     +NLR LL   N   +
Sbjct: 512 VDPQKMKMMENLTTLDLQNNDLLQIP-PELGNCVNLRTLLLDGNPFRV 558



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 53/193 (27%), Positives = 78/193 (40%), Gaps = 49/193 (25%)

Query: 756 TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
           +L SL  L+L SN+  S P+ + +M  + +LD +                          
Sbjct: 174 SLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNS------------------------- 208

Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875
           N L  +P  L   +E LE L L  NK+  +        LK L++ +N I  L    L+  
Sbjct: 209 NLLETIPPELAG-MESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLK-- 265

Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935
                    +N          S+ +L L  NK   +P+ I+ L  L  LD+S+NDI  LP
Sbjct: 266 --------HLN----------SILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 307

Query: 936 ---GPAHWKSLNL 945
              G  H K L L
Sbjct: 308 YSLGNLHLKFLAL 320



 Score = 35.4 bits (80), Expect = 1.3
 Identities = 61/252 (24%), Positives = 103/252 (40%), Gaps = 23/252 (9%)

Query: 608 LLLRRLA-LDVANNSICLGGFCIGKVEPSWLG----PLFPDKTSNLRKQTNIASTLARMV 662
           +LLR L  LD++NN I    + +G +   +L     PL   +   + K T       R  
Sbjct: 288 ILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 347

Query: 663 IR----YQMKSAVEEGTASGSDG--NFSEDVLSKFDEW-----TFIPDSSMDSVFAQSDD 711
           I+     Q +SA E      S+   N    +  K  ++     T IPD   D+V  +S+ 
Sbjct: 348 IKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAV--KSNI 405

Query: 712 LDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL-TLKSLTHLDLHSNKF 770
           + S     + L +     + + E   D  L      L   S  L  L+ LT LDL +N  
Sbjct: 406 VTSINFSKNQLCEIPKRMVELKEMVSDVDLS--FNKLSFISLELCVLQKLTFLDLRNNFL 463

Query: 771 TSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVE 830
            S P  +  +  +  +++S N     ++ +   +  TL+   +S NQ+  V      ++E
Sbjct: 464 NSLPEEMESLVRLQTINLSFNRF--KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMME 521

Query: 831 KLEQLILEGNKI 842
            L  L L+ N +
Sbjct: 522 NLTTLDLQNNDL 533



>gi|51094908|gb|EAL24153.1|   similar to hypothetical protein 4932412H11 [Homo sapiens]
 gi|42658047|ref|XP_376648.1|   PREDICTED: similar to hypothetical protein 4932412H11 [Homo sapiens]
 gi|42658502|ref|XP_379887.1|   PREDICTED: similar to hypothetical protein 4932412H11 [Homo sapiens]
          Length = 651

 Score = 83.2 bits (204), Expect = 5e-15
 Identities = 82/273 (30%), Positives = 134/273 (49%), Gaps = 17/273 (6%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDV---SRNDIGPSVVLDPTVKCPTLKQFNL 813
            L ++  L  ++N   +FPS L    C+ NL++    +N +       P++K  TL+  NL
Sbjct: 233  LGNIRQLFFYNNYIENFPSDL---ECLGNLEILSLGKNKLRHIPDTLPSLK--TLRVLNL 287

Query: 814  SYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLSENFL 872
             YNQL+  P+ L   + KL  L L GN IS +   +R LK L+ L +  N ++ L+    
Sbjct: 288  EYNQLTTFPKALC-FLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIF 346

Query: 873  EACPKVESFSARMNFLAAMPFLPPS---MTILKLSQNKFSCIPEAILNLPHLRSLDMSSN 929
            +   K++      N L  +     +   + IL L +N    IPE I     L  L +S N
Sbjct: 347  QLL-KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDN 405

Query: 930  DIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC 989
             +  LP   H K  NLR+L  + N + +  L  +    +++++L +S+N ++EIP  IG 
Sbjct: 406  KLTELPKYIH-KLNNLRKLHVNRNNM-LTRLPGELSNMTQLKELDISNNAIREIPRNIGE 463

Query: 990  LENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            L NL SL  +YN ++   P  +  L+ +  L L
Sbjct: 464  LRNLVSLH-AYNNQISYLPPSLLSLNDLQQLNL 495



 Score = 73.6 bits (179), Expect = 4e-12
 Identities = 74/270 (27%), Positives = 139/270 (51%), Gaps = 13/270 (4%)

Query: 756  TLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
            +LK+L  L+L  N+ T+FP  L  +  + +LD++ N I  S +     +   L+   + +
Sbjct: 278  SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLI--SSLPKEIRELKNLETLLMDH 335

Query: 816  NQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEA 874
            N+L+F+   +  ++ K+++L L  NK+  I   +   +EL+IL L KN + ++ E  +  
Sbjct: 336  NKLTFLAVEIFQLL-KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEK-ISC 393

Query: 875  CPKVESFSARMNFLAAMP-FLPPSMTILKLSQNK---FSCIPEAILNLPHLRSLDMSSND 930
            C  +E  S   N L  +P ++     + KL  N+    + +P  + N+  L+ LD+S+N 
Sbjct: 394  CAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMLTRLPGELSNMTQLKELDISNNA 453

Query: 931  IQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCL 990
            I+ +P     +  NL  L   +NQIS L  S  +   + +++L+LS N L  +P  I  +
Sbjct: 454  IREIPRNI-GELRNLVSLHAYNNQISYLPPSLLSL--NDLQQLNLSGNNLTALPSAIYNI 510

Query: 991  ENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020
             +L  ++   N  LR  P E+ K  +++ +
Sbjct: 511  FSLKEINFDDNPLLRP-PVEICKGKQLYTI 539



 Score = 73.6 bits (179), Expect = 4e-12
 Identities = 79/281 (28%), Positives = 132/281 (46%), Gaps = 23/281 (8%)

Query: 752  SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF 811
            ++S  L  L  L L  N  +S PS +  +  +  L+VS N I  S +     +   ++Q 
Sbjct: 182  ADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHI--SHIPKEISQLGNIRQL 239

Query: 812  NLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSEN 870
                N +   P +L + +  LE L L  NK+  I   L  LK L++LNL  N +++  + 
Sbjct: 240  FFYNNYIENFPSDL-ECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKA 298

Query: 871  FLEACPKVESFSARMNFLAAMPFLP---PSMTILKLSQNKFSCIPEAILNLPHLRSLDMS 927
             L   PK+ S     N ++++P       ++  L +  NK + +   I  L  ++ L ++
Sbjct: 299  -LCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLA 357

Query: 928  SNDIQYLPGPAHWKSLNLRELLFSHNQISILD------LSEKAYLWSRVEKLHLSHNKLK 981
             N ++ +   +H K  N REL     +I ILD      + EK    + +E L LS NKL 
Sbjct: 358  DNKLEVI---SH-KIENFREL-----RILILDKNLLKNIPEKISCCAMLECLSLSDNKLT 408

Query: 982  EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            E+P  I  L NL  L V+ N  L   P E+  ++++ +L +
Sbjct: 409  ELPKYIHKLNNLRKLHVNRNNMLTRLPGELSNMTQLKELDI 449



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 44/188 (23%), Positives = 76/188 (40%), Gaps = 11/188 (5%)

Query: 834  QLILEGNKISGICSPLRLKELKILNLSKNHI-SSLSENFLEACPKVESFSARMNFLAAMP 892
            Q  LE    SG  S    ++ K L  S+    +  S++      +   + A +NFL+   
Sbjct: 62   QNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHET 121

Query: 893  FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSH 952
                S  + + +Q +     +         ++++ +  +Q  P     K   ++ L    
Sbjct: 122  VGEVSPQVSEENQKQLGLGADNF-------TVNLEAKGLQEFPKDI-LKIKYVKYLYLDK 173

Query: 953  NQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMG 1012
            NQI     ++   L   +E L L  N L  +P EI  L NL  L+VS+N  +   P E+ 
Sbjct: 174  NQIKTFQGADSGDLLG-LEILSLQENGLSSLPSEIQLLHNLRILNVSHN-HISHIPKEIS 231

Query: 1013 KLSKIWDL 1020
            +L  I  L
Sbjct: 232  QLGNIRQL 239



>gi|56204430|emb|CAI22426.1|   OTTHUMP00000065337 [Homo sapiens]
 gi|56203373|emb|CAI23423.1|   OTTHUMP00000065337 [Homo sapiens]
 gi|55664510|emb|CAH73692.1|   OTTHUMP00000065337 [Homo sapiens]
 gi|55663984|emb|CAH74019.1|   OTTHUMP00000065337 [Homo sapiens]
 gi|55661894|emb|CAH70975.1|   OTTHUMP00000065337 [Homo sapiens]
          Length = 1495

 Score = 82.0 bits (201), Expect = 1e-14
 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 31/271 (11%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817
            ++L  L +  N  ++ P+ +  +  +  LD+S+N +          KC T+     S N 
Sbjct: 74   QALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI--IEASVNP 131

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            +S +P+  T ++  L QL L    +  + +   RL +L+IL L +NH+ +L ++      
Sbjct: 132  ISKLPDGFTQLLN-LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS------ 184

Query: 877  KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                    M+ LA        +  L L  N+F  +PE +  + +LR L M +N +Q LPG
Sbjct: 185  --------MHKLA-------QLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 229

Query: 937  PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996
             +  K   L  L  S N+I  +D+         +E L LS N L+++P  IG L+ LT+L
Sbjct: 230  -SIGKLKMLVYLDMSKNRIETVDMDISG--CEALEDLLLSSNMLQQLPDSIGLLKKLTTL 286

Query: 997  DVSYNLELRSFPNEMGKLSKI--WDLPLDEL 1025
             V  N +L   PN +G LS +  +D   +EL
Sbjct: 287  KVDDN-QLTMLPNTIGNLSLLEEFDCSCNEL 316



 Score = 76.6 bits (187), Expect = 5e-13
 Identities = 83/330 (25%), Positives = 150/330 (45%), Gaps = 23/330 (6%)

Query: 710  DDLDSEGSEGSFLVKKKSNSIS---VGEFYRDAVLQRCSPNLQRHSNSLT--------LK 758
            +DL +  +  + LV  K   IS   V EF  +    +C   ++   N ++        L 
Sbjct: 84   NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 143

Query: 759  SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818
            +LT L L+       P+   ++  +  L++  N +    +     K   L++ +L  N+ 
Sbjct: 144  NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL--KTLPKSMHKLAQLERLDLGNNEF 201

Query: 819  SFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPK 877
              +PE L D ++ L +L ++ N +  +   + +LK L  L++SKN I ++  + +  C  
Sbjct: 202  GELPEVL-DQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEA 259

Query: 878  VESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
            +E      N L  +P    L   +T LK+  N+ + +P  I NL  L   D S N+++ L
Sbjct: 260  LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 319

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994
            P    +   +LR L    N +   +L  +      V  + L  NKL+ +P EIG ++ L 
Sbjct: 320  PSTIGYLH-SLRTLAVDENFLP--ELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR 376

Query: 995  SLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
             L++S N  L++ P    KL ++  L L +
Sbjct: 377  VLNLSDN-RLKNLPFSFTKLKELAALWLSD 405



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 60/228 (26%), Positives = 102/228 (44%), Gaps = 30/228 (13%)

Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
           L  L  LDL +N+F   P  L ++  +  L +  N +   V+     K   L   ++S N
Sbjct: 188 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL--QVLPGSIGKLKMLVYLDMSKN 245

Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHIS---------S 866
           ++  V  +++   E LE L+L  N +  +   + L K+L  L +  N ++         S
Sbjct: 246 RIETVDMDISGC-EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 304

Query: 867 LSENFLEACPKVESFSARMNFLAAMP-------FLPP---------SMTILKLSQNKFSC 910
           L E F  +C ++ES  + + +L ++        FLP          ++T++ L  NK   
Sbjct: 305 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEF 364

Query: 911 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958
           +PE I  +  LR L++S N ++ LP  +  K   L  L  S NQ   L
Sbjct: 365 LPEEIGQMQKLRVLNLSDNRLKNLPF-SFTKLKELAALWLSDNQSKAL 411



>gi|56204429|emb|CAI22425.1|   OTTHUMP00000065336 [Homo sapiens]
 gi|55664509|emb|CAH73691.1|   OTTHUMP00000065336 [Homo sapiens]
 gi|55663983|emb|CAH74018.1|   OTTHUMP00000065336 [Homo sapiens]
 gi|55661893|emb|CAH70974.1|   OTTHUMP00000065336 [Homo sapiens]
 gi|16904383|ref|NP_065845.1|   leucine rich repeat containing 7 [Homo sapiens]
 gi|16755893|gb|AAL28133.1|   densin-180 [Homo sapiens]
 gi|50401129|sp|Q96NW7|LRR7_HUMAN   Leucine-rich repeat-containing protein 7 (LAP1 protein) (Densin-180)
          Length = 1537

 Score = 82.0 bits (201), Expect = 1e-14
 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 31/271 (11%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817
            ++L  L +  N  ++ P+ +  +  +  LD+S+N +          KC T+     S N 
Sbjct: 69   QALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI--IEASVNP 126

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            +S +P+  T ++  L QL L    +  + +   RL +L+IL L +NH+ +L ++      
Sbjct: 127  ISKLPDGFTQLLN-LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS------ 179

Query: 877  KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                    M+ LA        +  L L  N+F  +PE +  + +LR L M +N +Q LPG
Sbjct: 180  --------MHKLA-------QLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 224

Query: 937  PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996
             +  K   L  L  S N+I  +D+         +E L LS N L+++P  IG L+ LT+L
Sbjct: 225  -SIGKLKMLVYLDMSKNRIETVDMDISG--CEALEDLLLSSNMLQQLPDSIGLLKKLTTL 281

Query: 997  DVSYNLELRSFPNEMGKLSKI--WDLPLDEL 1025
             V  N +L   PN +G LS +  +D   +EL
Sbjct: 282  KVDDN-QLTMLPNTIGNLSLLEEFDCSCNEL 311



 Score = 76.6 bits (187), Expect = 5e-13
 Identities = 83/330 (25%), Positives = 150/330 (45%), Gaps = 23/330 (6%)

Query: 710  DDLDSEGSEGSFLVKKKSNSIS---VGEFYRDAVLQRCSPNLQRHSNSLT--------LK 758
            +DL +  +  + LV  K   IS   V EF  +    +C   ++   N ++        L 
Sbjct: 79   NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 138

Query: 759  SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818
            +LT L L+       P+   ++  +  L++  N +    +     K   L++ +L  N+ 
Sbjct: 139  NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL--KTLPKSMHKLAQLERLDLGNNEF 196

Query: 819  SFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPK 877
              +PE L D ++ L +L ++ N +  +   + +LK L  L++SKN I ++  + +  C  
Sbjct: 197  GELPEVL-DQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEA 254

Query: 878  VESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
            +E      N L  +P    L   +T LK+  N+ + +P  I NL  L   D S N+++ L
Sbjct: 255  LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994
            P    +   +LR L    N +   +L  +      V  + L  NKL+ +P EIG ++ L 
Sbjct: 315  PSTIGYLH-SLRTLAVDENFLP--ELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR 371

Query: 995  SLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
             L++S N  L++ P    KL ++  L L +
Sbjct: 372  VLNLSDN-RLKNLPFSFTKLKELAALWLSD 400



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 60/228 (26%), Positives = 102/228 (44%), Gaps = 30/228 (13%)

Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
           L  L  LDL +N+F   P  L ++  +  L +  N +   V+     K   L   ++S N
Sbjct: 183 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL--QVLPGSIGKLKMLVYLDMSKN 240

Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHIS---------S 866
           ++  V  +++   E LE L+L  N +  +   + L K+L  L +  N ++         S
Sbjct: 241 RIETVDMDISGC-EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299

Query: 867 LSENFLEACPKVESFSARMNFLAAMP-------FLPP---------SMTILKLSQNKFSC 910
           L E F  +C ++ES  + + +L ++        FLP          ++T++ L  NK   
Sbjct: 300 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEF 359

Query: 911 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958
           +PE I  +  LR L++S N ++ LP  +  K   L  L  S NQ   L
Sbjct: 360 LPEEIGQMQKLRVLNLSDNRLKNLPF-SFTKLKELAALWLSDNQSKAL 406



>gi|51476914|emb|CAH18423.1|   hypothetical protein [Homo sapiens]
          Length = 1530

 Score = 82.0 bits (201), Expect = 1e-14
 Identities = 78/271 (28%), Positives = 130/271 (47%), Gaps = 31/271 (11%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817
            ++L  L +  N  ++ P+ +  +  +  LD+S+N +          KC T+     S N 
Sbjct: 62   QALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI--IEASVNP 119

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            +S +P+  T ++  L QL L    +  + +   RL +L+IL L +NH+ +L ++      
Sbjct: 120  ISKLPDGFTQLLN-LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS------ 172

Query: 877  KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                    M+ LA        +  L L  N+F  +PE +  + +LR L M +N +Q LPG
Sbjct: 173  --------MHKLA-------QLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPG 217

Query: 937  PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996
             +  K   L  L  S N+I  +D+         +E L LS N L+++P  IG L+ LT+L
Sbjct: 218  -SIGKLKMLVYLDMSKNRIETVDMDISG--CEALEDLLLSSNMLQQLPDSIGLLKKLTTL 274

Query: 997  DVSYNLELRSFPNEMGKLSKI--WDLPLDEL 1025
             V  N +L   PN +G LS +  +D   +EL
Sbjct: 275  KVDDN-QLTMLPNTIGNLSLLEEFDCSCNEL 304



 Score = 73.9 bits (180), Expect = 3e-12
 Identities = 82/330 (24%), Positives = 149/330 (45%), Gaps = 23/330 (6%)

Query: 710  DDLDSEGSEGSFLVKKKSNSIS---VGEFYRDAVLQRCSPNLQRHSNSLT--------LK 758
            +DL +  +  + LV  K   IS   V EF  +    +C   ++   N ++        L 
Sbjct: 72   NDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL 131

Query: 759  SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818
            +LT L L+       P+   ++  +  L++  N +    +     K   L++ +L  N+ 
Sbjct: 132  NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHL--KTLPKSMHKLAQLERLDLGNNEF 189

Query: 819  SFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPK 877
              +PE L D ++ L +L ++ N +  +   + +LK L  L++SKN I ++  + +  C  
Sbjct: 190  GELPEVL-DQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEA 247

Query: 878  VESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
            +E      N L  +P    L   +T LK+  N+ + +P  I NL  L   D S N+++ L
Sbjct: 248  LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 307

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLT 994
            P    +   +LR L    N +   +L  +      V  + L  NKL+ +P EIG ++ L 
Sbjct: 308  PSTIGYLH-SLRTLAVDENFLP--ELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR 364

Query: 995  SLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
              ++S N  L++ P    KL ++  L L +
Sbjct: 365  VPNLSDN-RLKNLPFSFTKLKELAALWLSD 393



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 59/228 (25%), Positives = 101/228 (44%), Gaps = 30/228 (13%)

Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
           L  L  LDL +N+F   P  L ++  +  L +  N +   V+     K   L   ++S N
Sbjct: 176 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNAL--QVLPGSIGKLKMLVYLDMSKN 233

Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRL-KELKILNLSKNHIS---------S 866
           ++  V  +++   E LE L+L  N +  +   + L K+L  L +  N ++         S
Sbjct: 234 RIETVDMDISGC-EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 292

Query: 867 LSENFLEACPKVESFSARMNFLAAMP-------FLPP---------SMTILKLSQNKFSC 910
           L E F  +C ++ES  + + +L ++        FLP          ++T++ L  NK   
Sbjct: 293 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEF 352

Query: 911 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958
           +PE I  +  LR  ++S N ++ LP  +  K   L  L  S NQ   L
Sbjct: 353 LPEEIGQMQKLRVPNLSDNRLKNLPF-SFTKLKELAALWLSDNQSKAL 399



>gi|29791785|gb|AAH50692.1|   ERBB2IP protein [Homo sapiens]
          Length = 633

 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%)

Query: 735  FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794
            +  DA L+    N  R      L  L  L+L  N+    P  + +++ +  LD+  N+  
Sbjct: 144  YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854
             + V +   +   LK+F +  N+L+F+P  +                         LK+L
Sbjct: 197  -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232

Query: 855  KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911
              L++SKN+I  + E  +  C  ++      N L  +P    S+   T LK+ +N+   +
Sbjct: 233  TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291

Query: 912  PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971
            P++I  L  +  LD S N+++ LP  +  +  NLR     HN +    L  +   W  + 
Sbjct: 292  PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017
             L L  NKL+ +P E+G ++ L  +++S N  L++ P    KL ++
Sbjct: 349  VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393



 Score = 79.3 bits (194), Expect = 8e-14
 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817
            +SL  L L  N  T+ P+ +  +  +  LDVS+N  G     +    C  L     S N 
Sbjct: 69   QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            +S +P+  + ++  L QL L    +  + +   RL +L+IL L +N +  L +  +    
Sbjct: 127  ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184

Query: 877  KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933
            ++E      N    +P +   ++ LK   +  N+ + IP  I +L  L  LD+S N+I+ 
Sbjct: 185  QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244

Query: 934  LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993
            +         NL++LL S N  S+  L E       +  L +  N+L  +P  IG L ++
Sbjct: 245  VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053
              LD S+N E+ + P+ +G+L+ +     D  +L      IG      + FL     + +
Sbjct: 302  EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360

Query: 1054 P 1054
            P
Sbjct: 361  P 361



 Score = 60.8 bits (146), Expect = 3e-08
 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%)

Query: 807  TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849
            T+   + S+  L  VP+ +    + LE+L L+ N+I  +      C  L           
Sbjct: 23   TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82

Query: 850  -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892
                    L  L+ L++SKN I    EN ++ C  +    A +N ++ +P          
Sbjct: 83   TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

Query: 893  ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                      FLP +      + IL+L +N+   +P+ +  L  L  LD+ SN+   +P 
Sbjct: 142  QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201

Query: 937  --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976
                       W   N    +   + S  Q++ LD+S        E       ++ L LS
Sbjct: 202  VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261

Query: 977  HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020
             N L+++P  IG L+N+T+L +  N +L   P+ +G L  + +L
Sbjct: 262  SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304



 Score = 42.4 bits (98), Expect = 0.011
 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%)

Query: 846  CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
            C  LR +E  +  L  +H S      LE  PK E F+              ++  L L  
Sbjct: 14   CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            N+   +P+ + N   L  L +  ND+  LP       +NLREL  S N   I +  E   
Sbjct: 56   NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025
                +  +  S N + ++P     L NLT L ++ +  L   P   G+L+K+  L L E 
Sbjct: 113  NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171

Query: 1026 HL 1027
             L
Sbjct: 172  QL 173



>gi|55770895|ref|NP_001006600.1|   ERBB2 interacting protein isoform 7; densin-180-like protein;
            ERBB2-interacting protein [Homo sapiens]
          Length = 1302

 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%)

Query: 735  FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794
            +  DA L+    N  R      L  L  L+L  N+    P  + +++ +  LD+  N+  
Sbjct: 144  YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854
             + V +   +   LK+F +  N+L+F+P  +                         LK+L
Sbjct: 197  -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232

Query: 855  KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911
              L++SKN+I  + E  +  C  ++      N L  +P    S+   T LK+ +N+   +
Sbjct: 233  TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291

Query: 912  PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971
            P++I  L  +  LD S N+++ LP  +  +  NLR     HN +    L  +   W  + 
Sbjct: 292  PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017
             L L  NKL+ +P E+G ++ L  +++S N  L++ P    KL ++
Sbjct: 349  VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393



 Score = 79.3 bits (194), Expect = 8e-14
 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817
            +SL  L L  N  T+ P+ +  +  +  LDVS+N  G     +    C  L     S N 
Sbjct: 69   QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            +S +P+  + ++  L QL L    +  + +   RL +L+IL L +N +  L +  +    
Sbjct: 127  ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184

Query: 877  KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933
            ++E      N    +P +   ++ LK   +  N+ + IP  I +L  L  LD+S N+I+ 
Sbjct: 185  QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244

Query: 934  LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993
            +         NL++LL S N  S+  L E       +  L +  N+L  +P  IG L ++
Sbjct: 245  VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053
              LD S+N E+ + P+ +G+L+ +     D  +L      IG      + FL     + +
Sbjct: 302  EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360

Query: 1054 P 1054
            P
Sbjct: 361  P 361



 Score = 60.8 bits (146), Expect = 3e-08
 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%)

Query: 807  TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849
            T+   + S+  L  VP+ +    + LE+L L+ N+I  +      C  L           
Sbjct: 23   TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82

Query: 850  -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892
                    L  L+ L++SKN I    EN ++ C  +    A +N ++ +P          
Sbjct: 83   TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

Query: 893  ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                      FLP +      + IL+L +N+   +P+ +  L  L  LD+ SN+   +P 
Sbjct: 142  QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201

Query: 937  --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976
                       W   N    +   + S  Q++ LD+S        E       ++ L LS
Sbjct: 202  VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261

Query: 977  HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020
             N L+++P  IG L+N+T+L +  N +L   P+ +G L  + +L
Sbjct: 262  SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304



 Score = 42.4 bits (98), Expect = 0.011
 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%)

Query: 846  CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
            C  LR +E  +  L  +H S      LE  PK E F+              ++  L L  
Sbjct: 14   CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            N+   +P+ + N   L  L +  ND+  LP       +NLREL  S N   I +  E   
Sbjct: 56   NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025
                +  +  S N + ++P     L NLT L ++ +  L   P   G+L+K+  L L E 
Sbjct: 113  NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171

Query: 1026 HL 1027
             L
Sbjct: 172  QL 173



>gi|8923909|ref|NP_061165.1|   ERBB2 interacting protein isoform 2 [Homo sapiens]
 gi|8572221|gb|AAF77048.1|   erbb2-interacting protein ERBIN [Homo sapiens]
 gi|20521800|dbj|BAA86539.2|   KIAA1225 protein [Homo sapiens]
          Length = 1371

 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%)

Query: 735  FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794
            +  DA L+    N  R      L  L  L+L  N+    P  + +++ +  LD+  N+  
Sbjct: 144  YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854
             + V +   +   LK+F +  N+L+F+P  +                         LK+L
Sbjct: 197  -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232

Query: 855  KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911
              L++SKN+I  + E  +  C  ++      N L  +P    S+   T LK+ +N+   +
Sbjct: 233  TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291

Query: 912  PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971
            P++I  L  +  LD S N+++ LP  +  +  NLR     HN +    L  +   W  + 
Sbjct: 292  PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017
             L L  NKL+ +P E+G ++ L  +++S N  L++ P    KL ++
Sbjct: 349  VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393



 Score = 79.3 bits (194), Expect = 8e-14
 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817
            +SL  L L  N  T+ P+ +  +  +  LDVS+N  G     +    C  L     S N 
Sbjct: 69   QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            +S +P+  + ++  L QL L    +  + +   RL +L+IL L +N +  L +  +    
Sbjct: 127  ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184

Query: 877  KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933
            ++E      N    +P +   ++ LK   +  N+ + IP  I +L  L  LD+S N+I+ 
Sbjct: 185  QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244

Query: 934  LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993
            +         NL++LL S N  S+  L E       +  L +  N+L  +P  IG L ++
Sbjct: 245  VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053
              LD S+N E+ + P+ +G+L+ +     D  +L      IG      + FL     + +
Sbjct: 302  EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360

Query: 1054 P 1054
            P
Sbjct: 361  P 361



 Score = 60.8 bits (146), Expect = 3e-08
 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%)

Query: 807  TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849
            T+   + S+  L  VP+ +    + LE+L L+ N+I  +      C  L           
Sbjct: 23   TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82

Query: 850  -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892
                    L  L+ L++SKN I    EN ++ C  +    A +N ++ +P          
Sbjct: 83   TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

Query: 893  ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                      FLP +      + IL+L +N+   +P+ +  L  L  LD+ SN+   +P 
Sbjct: 142  QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201

Query: 937  --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976
                       W   N    +   + S  Q++ LD+S        E       ++ L LS
Sbjct: 202  VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261

Query: 977  HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020
             N L+++P  IG L+N+T+L +  N +L   P+ +G L  + +L
Sbjct: 262  SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304



 Score = 42.4 bits (98), Expect = 0.011
 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%)

Query: 846  CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
            C  LR +E  +  L  +H S      LE  PK E F+              ++  L L  
Sbjct: 14   CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            N+   +P+ + N   L  L +  ND+  LP       +NLREL  S N   I +  E   
Sbjct: 56   NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025
                +  +  S N + ++P     L NLT L ++ +  L   P   G+L+K+  L L E 
Sbjct: 113  NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171

Query: 1026 HL 1027
             L
Sbjct: 172  QL 173



>gi|14582259|gb|AAK69431.1|   densin-180-like protein [Homo sapiens]
 gi|50401131|sp|Q96RT1|LAP2_HUMAN   LAP2 protein (Erbb2-interacting protein) (Erbin) (Densin-180-like
            protein)
          Length = 1412

 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 71/286 (24%), Positives = 128/286 (44%), Gaps = 39/286 (13%)

Query: 735  FYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 794
            +  DA L+    N  R      L  L  L+L  N+    P  + +++ +  LD+  N+  
Sbjct: 144  YLNDAFLEFLPANFGR------LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEF- 196

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKEL 854
             + V +   +   LK+F +  N+L+F+P  +                         LK+L
Sbjct: 197  -TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGS-----------------------LKQL 232

Query: 855  KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCI 911
              L++SKN+I  + E  +  C  ++      N L  +P    S+   T LK+ +N+   +
Sbjct: 233  TYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291

Query: 912  PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVE 971
            P++I  L  +  LD S N+++ LP  +  +  NLR     HN +    L  +   W  + 
Sbjct: 292  PDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--QLPPEIGSWKNIT 348

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1017
             L L  NKL+ +P E+G ++ L  +++S N  L++ P    KL ++
Sbjct: 349  VLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393



 Score = 79.3 bits (194), Expect = 8e-14
 Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 12/301 (3%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQ 817
            +SL  L L  N  T+ P+ +  +  +  LDVS+N  G     +    C  L     S N 
Sbjct: 69   QSLHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNP 126

Query: 818  LSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACP 876
            +S +P+  + ++  L QL L    +  + +   RL +L+IL L +N +  L +  +    
Sbjct: 127  ISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLT 184

Query: 877  KVESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQY 933
            ++E      N    +P +   ++ LK   +  N+ + IP  I +L  L  LD+S N+I+ 
Sbjct: 185  QLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEM 244

Query: 934  LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENL 993
            +         NL++LL S N  S+  L E       +  L +  N+L  +P  IG L ++
Sbjct: 245  VEEGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISV 301

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAV 1053
              LD S+N E+ + P+ +G+L+ +     D  +L      IG      + FL     + +
Sbjct: 302  EELDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360

Query: 1054 P 1054
            P
Sbjct: 361  P 361



 Score = 60.8 bits (146), Expect = 3e-08
 Identities = 67/284 (23%), Positives = 117/284 (41%), Gaps = 72/284 (25%)

Query: 807  TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI------CSPL----------- 849
            T+   + S+  L  VP+ +    + LE+L L+ N+I  +      C  L           
Sbjct: 23   TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82

Query: 850  -------RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMP---------- 892
                    L  L+ L++SKN I    EN ++ C  +    A +N ++ +P          
Sbjct: 83   TLPASIANLINLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

Query: 893  ----------FLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                      FLP +      + IL+L +N+   +P+ +  L  L  LD+ SN+   +P 
Sbjct: 142  QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201

Query: 937  --------PAHWKSLN----LRELLFSHNQISILDLS--------EKAYLWSRVEKLHLS 976
                       W   N    +   + S  Q++ LD+S        E       ++ L LS
Sbjct: 202  VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261

Query: 977  HNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020
             N L+++P  IG L+N+T+L +  N +L   P+ +G L  + +L
Sbjct: 262  SNSLQQLPETIGSLKNITTLKIDEN-QLMYLPDSIGGLISVEEL 304



 Score = 42.4 bits (98), Expect = 0.011
 Identities = 50/182 (27%), Positives = 75/182 (41%), Gaps = 22/182 (12%)

Query: 846  CSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
            C  LR +E  +  L  +H S      LE  PK E F+              ++  L L  
Sbjct: 14   CRCLRGEEETVTTLDYSHCS------LEQVPK-EIFT-----------FEKTLEELYLDA 55

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            N+   +P+ + N   L  L +  ND+  LP       +NLREL  S N   I +  E   
Sbjct: 56   NQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKN--GIQEFPENIK 112

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDEL 1025
                +  +  S N + ++P     L NLT L ++ +  L   P   G+L+K+  L L E 
Sbjct: 113  NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN-DAFLEFLPANFGRLTKLQILELREN 171

Query: 1026 HL 1027
             L
Sbjct: 172  QL 173



>gi|13112035|gb|AAH03193.1|   LRRC1 protein [Homo sapiens]
 gi|55960464|emb|CAI17358.1|   OTTHUMP00000039963 [Homo sapiens]
 gi|56202741|emb|CAI21666.1|   OTTHUMP00000039963 [Homo sapiens]
 gi|14701834|gb|AAK72246.1|   LANO adaptor protein [Homo sapiens]
 gi|14582756|gb|AAK69623.1|   leucine-rich repeats protein [Homo sapiens]
 gi|50401149|sp|Q9BTT6|LRR1_HUMAN   Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein)
            (LANO adapter protein)
          Length = 524

 Score = 80.1 bits (196), Expect = 5e-14
 Identities = 79/248 (31%), Positives = 122/248 (49%), Gaps = 11/248 (4%)

Query: 807  TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHIS 865
            +L++  L  NQL  +PE    +V KL +L L  N+I  +   +    +L  L++S+N I 
Sbjct: 37   SLEELLLDANQLRELPEQFFQLV-KLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIP 95

Query: 866  SLSENFLEACPKVESFSARMNFLAAMPFLPP---SMTILKLSQNKFSCIPEAILNLPHLR 922
             + E+ +  C  ++      N L  +P   P   ++T L ++      +PE I NL +L 
Sbjct: 96   EIPES-ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLA 154

Query: 923  SLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKE 982
            SL++  N + YLP     +   L EL   +N+I  L  S  A L   ++ L L  N+L E
Sbjct: 155  SLELRENLLTYLPDSLT-QLRRLEELDLGNNEIYNLPESIGALL--HLKDLWLDGNQLSE 211

Query: 983  IPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIG-CKAKDI 1041
            +P EIG L+NL  LDVS N  L   P E+  L+ + DL + +  L      IG  K   I
Sbjct: 212  LPQEIGNLKNLLCLDVSEN-RLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSI 270

Query: 1042 IRFLQQRL 1049
            ++  Q RL
Sbjct: 271  LKVDQNRL 278



 Score = 71.2 bits (173), Expect = 2e-11
 Identities = 71/271 (26%), Positives = 121/271 (44%), Gaps = 50/271 (18%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            L  L  L L  N+    P  +     +  LDVSRN+I    + +    C  L+  + S N
Sbjct: 58   LVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEI--PEIPESISFCKALQVADFSGN 115

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACP 876
             L+ +PE+  +                       L+ L  L+++   + SL EN      
Sbjct: 116  PLTRLPESFPE-----------------------LQNLTCLSVNDISLQSLPENI----- 147

Query: 877  KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
                    +  LA+          L+L +N  + +P+++  L  L  LD+ +N+I  LP 
Sbjct: 148  ------GNLYNLAS----------LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP- 190

Query: 937  PAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSL 996
             +    L+L++L    NQ+S  +L ++      +  L +S N+L+ +P EI  L +LT L
Sbjct: 191  ESIGALLHLKDLWLDGNQLS--ELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDL 248

Query: 997  DVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027
             +S NL L + P+ +GKL K+  L +D+  L
Sbjct: 249  VISQNL-LETIPDGIGKLKKLSILKVDQNRL 278



 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 65/270 (24%), Positives = 127/270 (47%), Gaps = 18/270 (6%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            L++LT L ++     S P  +  +  +A+L++  N +  + + D   +   L++ +L  N
Sbjct: 127  LQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLL--TYLPDSLTQLRRLEELDLGNN 184

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875
            ++  +PE++  ++  L+ L L+GN++S +   +  LK L  L++S+N +  L E  +   
Sbjct: 185  EIYNLPESIGALLH-LKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGL 242

Query: 876  PKVESFSARMNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQ 932
              +       N L  +P        ++ILK+ QN+ + +PEA+     L  L ++ N + 
Sbjct: 243  TSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLL 302

Query: 933  YLPGPAHWKSLNLRELLFSHN--QISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCL 990
             LP     KS+   + L + N  +  ++ L ++      +    +  N+L  IP E+   
Sbjct: 303  TLP-----KSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQA 357

Query: 991  ENLTSLDVSYNLELRSFPNEMG--KLSKIW 1018
              L  LDV+ N  L   P  +   KL  +W
Sbjct: 358  TELHVLDVAGN-RLLHLPLSLTALKLKALW 386



 Score = 55.8 bits (133), Expect = 9e-07
 Identities = 53/185 (28%), Positives = 86/185 (46%), Gaps = 10/185 (5%)

Query: 908  FSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLW 967
            F CIP    N  H+ S+D     + Y+P   +  + +L ELL   NQ+   +L E+ +  
Sbjct: 2    FHCIPLWRCNR-HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLR--ELPEQFFQL 58

Query: 968  SRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMG--KLSKIWDL---PL 1022
             ++ KL LS N+++ +PPEI     L  LDVS N E+   P  +   K  ++ D    PL
Sbjct: 59   VKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRN-EIPEIPESISFCKALQVADFSGNPL 117

Query: 1023 DELHLNF-DFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTK 1081
              L  +F + +++ C + + I            YN   L +  N  +     L QL + +
Sbjct: 118  TRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLE 177

Query: 1082 KSDLG 1086
            + DLG
Sbjct: 178  ELDLG 182



>gi|37221175|ref|NP_919431.1|   suprachiasmatic nucleus circadian oscillatory protein [Homo sapiens]
          Length = 1205

 Score = 79.7 bits (195), Expect = 6e-14
 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            +K L++L L  N+FT  P  L K++ +  L +S N +  ++ L    K P +K  +L  N
Sbjct: 247  MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 305

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874
             +  +  +  D ++ + QL L  NK+ G    +    +++L+  +N + +L     FL+A
Sbjct: 306  VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 364

Query: 875  CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
               + + S  +  L   P +P  ++ + +S+N+   +PE +     L  LD+  N I  L
Sbjct: 365  ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993
            P      S +LR+LL  HNQ++   L E+    S VE L + HN+L E+PP +    ++L
Sbjct: 421  PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 476

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027
              L+ S N +L S P     LS+  +  L EL+L
Sbjct: 477  RFLNASAN-KLESLP--PATLSEETNSILQELYL 507



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 57/215 (26%), Positives = 88/215 (40%), Gaps = 31/215 (14%)

Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
           SL  L+  +NK  S P   L     S +  L ++ N +    V   T   P LK  +++Y
Sbjct: 475 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 533

Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875
           N+L   P +    +E+LE++ L GNK+  I          I+N  + H      N +E  
Sbjct: 534 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCRRMHTVIAHSNCIEVF 586

Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933
           P+V                 P +  + LS N+ S   +PE +   P L+ LD++ N    
Sbjct: 587 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 630

Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968
           L         N+R   F  +Q S  D S    +WS
Sbjct: 631 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 663



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%)

Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827
           FT +  +L ++S +A+  +S  D+           C +L+    NL Y+Q      +LT 
Sbjct: 109 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 152

Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868
           +   L+Q  L  N       G+    R  +LK LNLS NH+                ++S
Sbjct: 153 L--NLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 210

Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918
            N L + P        +++F    NFL ++P    +M   + L LS N+F+ IPE +  L
Sbjct: 211 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 270

Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978
             +  L MS N ++ L   A  K  +++ +    N I  L   E  +L   V +L L  N
Sbjct: 271 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 329

Query: 979 KLKEI 983
           KL ++
Sbjct: 330 KLGDL 334



 Score = 37.0 bits (84), Expect = 0.45
 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%)

Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809
           S    L+ L  +DL  NK  + P+ ++    +  +    N  ++ P V+  P +KC    
Sbjct: 542 SKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC---- 597

Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840
             +LS N+LS V  PENL     KL++L L GN
Sbjct: 598 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 626



>gi|422993|pir||JU0229   mixed-lineage protein kinase 1 - human
 gi|462606|sp|P80192|M3K9_HUMAN   Mitogen-activated protein kinase kinase kinase 9 (Mixed lineage
            kinase 1)
 gi|299825|gb|AAB26359.1|   mixed-lineage kinase 1, MLK1=epithelial protein kinase [human, Colo
            16 cell line, Peptide, 394 aa]
          Length = 394

 Score = 79.7 bits (195), Expect = 6e-14
 Identities = 63/200 (31%), Positives = 103/200 (51%), Gaps = 18/200 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639
            LVME A  G L+R+L   +  +   +    A+ +A G+ YLH   I   I+RDLK  N+L
Sbjct: 77   LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 134

Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696
            +     N  +   I KI D+G+A+   R    ++ GT  + APEV R + ++++ +DV+S
Sbjct: 135  ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 193

Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754
            +G+LL+++LT     R ++GL+            KL  P+      P P   KL++ C  
Sbjct: 194  YGVLLWELLTGEVPFRGIDGLRVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 246

Query: 1755 ENPQERPTSAQVFDILNSAE 1774
             +P  RP+   + D L + E
Sbjct: 247  PDPHSRPSFTNILDQLTTIE 266



>gi|34809548|gb|AAH14927.2|   PLEKHE1 protein [Homo sapiens]
          Length = 1227

 Score = 79.7 bits (195), Expect = 6e-14
 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            +K L++L L  N+FT  P  L K++ +  L +S N +  ++ L    K P +K  +L  N
Sbjct: 269  MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 327

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874
             +  +  +  D ++ + QL L  NK+ G    +    +++L+  +N + +L     FL+A
Sbjct: 328  VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 386

Query: 875  CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
               + + S  +  L   P +P  ++ + +S+N+   +PE +     L  LD+  N I  L
Sbjct: 387  ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 442

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993
            P      S +LR+LL  HNQ++   L E+    S VE L + HN+L E+PP +    ++L
Sbjct: 443  PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 498

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027
              L+ S N +L S P     LS+  +  L EL+L
Sbjct: 499  RFLNASAN-KLESLP--PATLSEETNSILQELYL 529



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 57/215 (26%), Positives = 88/215 (40%), Gaps = 31/215 (14%)

Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
           SL  L+  +NK  S P   L     S +  L ++ N +    V   T   P LK  +++Y
Sbjct: 497 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 555

Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875
           N+L   P +    +E+LE++ L GNK+  I          I+N  + H      N +E  
Sbjct: 556 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCRRMHTVIAHSNCIEVF 608

Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933
           P+V                 P +  + LS N+ S   +PE +   P L+ LD++ N    
Sbjct: 609 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 652

Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968
           L         N+R   F  +Q S  D S    +WS
Sbjct: 653 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 685



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%)

Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827
           FT +  +L ++S +A+  +S  D+           C +L+    NL Y+Q      +LT 
Sbjct: 131 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 174

Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868
           +   L+Q  L  N       G+    R  +LK LNLS NH+                ++S
Sbjct: 175 L--NLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 232

Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918
            N L + P        +++F    NFL ++P    +M   + L LS N+F+ IPE +  L
Sbjct: 233 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 292

Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978
             +  L MS N ++ L   A  K  +++ +    N I  L   E  +L   V +L L  N
Sbjct: 293 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 351

Query: 979 KLKEI 983
           KL ++
Sbjct: 352 KLGDL 356



 Score = 37.0 bits (84), Expect = 0.45
 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%)

Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809
           S    L+ L  +DL  NK  + P+ ++    +  +    N  ++ P V+  P +KC    
Sbjct: 564 SKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC---- 619

Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840
             +LS N+LS V  PENL     KL++L L GN
Sbjct: 620 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 648



>gi|7023489|dbj|BAA91980.1|   unnamed protein product [Homo sapiens]
          Length = 721

 Score = 79.7 bits (195), Expect = 6e-14
 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            +K L++L L  N+FT  P  L K++ +  L +S N +  ++ L    K P +K  +L  N
Sbjct: 247  MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 305

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874
             +  +  +  D ++ + QL L  NK+ G    +    +++L+  +N + +L     FL+A
Sbjct: 306  VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 364

Query: 875  CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
               + + S  +  L   P +P  ++ + +S+N+   +PE +     L  LD+  N I  L
Sbjct: 365  ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 420

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993
            P      S +LR+LL  HNQ++   L E+    S VE L + HN+L E+PP +    ++L
Sbjct: 421  PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 476

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027
              L+ S N +L S P     LS+  +  L EL+L
Sbjct: 477  RFLNASAN-KLESLP--PATLSEETNSILQELYL 507



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 57/215 (26%), Positives = 88/215 (40%), Gaps = 31/215 (14%)

Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
           SL  L+  +NK  S P   L     S +  L ++ N +    V   T   P LK  +++Y
Sbjct: 475 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 533

Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875
           N+L   P +    +E+LE++ L GNK+  I          I+N  + H      N +E  
Sbjct: 534 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCRRMHTVIAHSNCIEVF 586

Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933
           P+V                 P +  + LS N+ S   +PE +   P L+ LD++ N    
Sbjct: 587 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 630

Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968
           L         N+R   F  +Q S  D S    +WS
Sbjct: 631 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 663



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%)

Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827
           FT +  +L ++S +A+  +S  D+           C +L+    NL Y+Q      +LT 
Sbjct: 109 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 152

Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868
           +   L+Q  L  N       G+    R  +LK LNLS NH+                ++S
Sbjct: 153 L--NLKQNFLRQNPSLPAARGLNELQRFAKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 210

Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918
            N L + P        +++F    NFL ++P    +M   + L LS N+F+ IPE +  L
Sbjct: 211 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 270

Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978
             +  L MS N ++ L   A  K  +++ +    N I  L   E  +L   V +L L  N
Sbjct: 271 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 329

Query: 979 KLKEI 983
           KL ++
Sbjct: 330 KLGDL 334



 Score = 37.0 bits (84), Expect = 0.45
 Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 12/93 (12%)

Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809
           S    L+ L  +DL  NK  + P+ ++    +  +    N  ++ P V+  P +KC    
Sbjct: 542 SKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC---- 597

Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840
             +LS N+LS V  PENL     KL++L L GN
Sbjct: 598 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 626



>gi|20521103|dbj|BAA25532.2|   KIAA0606 protein [Homo sapiens]
          Length = 1369

 Score = 79.7 bits (195), Expect = 6e-14
 Identities = 80/274 (29%), Positives = 138/274 (50%), Gaps = 16/274 (5%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            +K L++L L  N+FT  P  L K++ +  L +S N +  ++ L    K P +K  +L  N
Sbjct: 411  MKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLN 469

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEA 874
             +  +  +  D ++ + QL L  NK+ G    +    +++L+  +N + +L     FL+A
Sbjct: 470  VIRKLIADEVDFLQHVTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA 528

Query: 875  CPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
               + + S  +  L   P +P  ++ + +S+N+   +PE +     L  LD+  N I  L
Sbjct: 529  ---LYASSNELVQLDVYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICEL 584

Query: 935  PGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENL 993
            P      S +LR+LL  HNQ++   L E+    S VE L + HN+L E+PP +    ++L
Sbjct: 585  PARLFCNS-SLRKLLAGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSL 640

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1027
              L+ S N +L S P     LS+  +  L EL+L
Sbjct: 641  RFLNASAN-KLESLP--PATLSEETNSILQELYL 671



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 58/215 (26%), Positives = 89/215 (41%), Gaps = 31/215 (14%)

Query: 759 SLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSY 815
           SL  L+  +NK  S P   L     S +  L ++ N +    V   T   P LK  +++Y
Sbjct: 639 SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSLTDKCVPLLTGH-PHLKILHMAY 697

Query: 816 NQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEAC 875
           N+L   P +    +E+LE++ L GNK+  I          I+N S+ H      N +E  
Sbjct: 698 NRLQSFPASKMAKLEELEEIDLSGNKLKAI-------PTTIMNCSRMHTVIAHSNCIEVF 750

Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--CIPEAILNLPHLRSLDMSSNDIQY 933
           P+V                 P +  + LS N+ S   +PE +   P L+ LD++ N    
Sbjct: 751 PEVMQL--------------PEIKCVDLSCNELSEVTLPENL--PPKLQELDLTGNPRLV 794

Query: 934 LPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 968
           L         N+R   F  +Q S  D S    +WS
Sbjct: 795 LDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 827



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%)

Query: 770 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 827
           FT +  +L ++S +A+  +S  D+           C +L+    NL Y+Q      +LT 
Sbjct: 273 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 316

Query: 828 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 868
           +   L+Q  L  N       G+    R  +LK LNLS NH+                ++S
Sbjct: 317 L--NLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 374

Query: 869 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 918
            N L + P        +++F    NFL ++P    +M   + L LS N+F+ IPE +  L
Sbjct: 375 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 434

Query: 919 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 978
             +  L MS N ++ L   A  K  +++ +    N I  L   E  +L   V +L L  N
Sbjct: 435 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 493

Query: 979 KLKEI 983
           KL ++
Sbjct: 494 KLGDL 498



 Score = 38.9 bits (89), Expect = 0.12
 Identities = 31/93 (33%), Positives = 47/93 (50%), Gaps = 12/93 (12%)

Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLK 809
           S    L+ L  +DL  NK  + P+ ++  S +  +    N  ++ P V+  P +KC    
Sbjct: 706 SKMAKLEELEEIDLSGNKLKAIPTTIMNCSRMHTVIAHSNCIEVFPEVMQLPEIKC---- 761

Query: 810 QFNLSYNQLSFV--PENLTDVVEKLEQLILEGN 840
             +LS N+LS V  PENL     KL++L L GN
Sbjct: 762 -VDLSCNELSEVTLPENLP---PKLQELDLTGN 790



>gi|52421790|ref|NP_149132.2|   mitogen-activated protein kinase kinase kinase 9 [Homo sapiens]
          Length = 1118

 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 63/200 (31%), Positives = 102/200 (51%), Gaps = 18/200 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639
            LVME A  G L+R+L   +  +   +    A+ +A G+ YLH   I   I+RDLK  N+L
Sbjct: 218  LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 275

Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696
            +     N  +   I KI D+G+A+   R    ++ GT  + APEV R + ++++ +DV+S
Sbjct: 276  ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 334

Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754
            +G+LL+++LT     R ++GL             KL  P+      P P   KL++ C  
Sbjct: 335  YGVLLWELLTGEVPFRGIDGLAVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 387

Query: 1755 ENPQERPTSAQVFDILNSAE 1774
             +P  RP+   + D L + E
Sbjct: 388  PDPHSRPSFTNILDQLTTIE 407



>gi|33591094|gb|AAQ23054.1|   mixed-lineage protein kinase 1 [Homo sapiens]
          Length = 1104

 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 63/200 (31%), Positives = 102/200 (51%), Gaps = 18/200 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639
            LVME A  G L+R+L   +  +   +    A+ +A G+ YLH   I   I+RDLK  N+L
Sbjct: 218  LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 275

Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696
            +     N  +   I KI D+G+A+   R    ++ GT  + APEV R + ++++ +DV+S
Sbjct: 276  ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 334

Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754
            +G+LL+++LT     R ++GL             KL  P+      P P   KL++ C  
Sbjct: 335  YGVLLWELLTGEVPFRGIDGLAVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 387

Query: 1755 ENPQERPTSAQVFDILNSAE 1774
             +P  RP+   + D L + E
Sbjct: 388  PDPHSRPSFTNILDQLTTIE 407



>gi|12005724|gb|AAG44591.1|   mixed lineage kinase MLK1 [Homo sapiens]
          Length = 1066

 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 63/200 (31%), Positives = 102/200 (51%), Gaps = 18/200 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMI---IYRDLKPHNVL 1639
            LVME A  G L+R+L   +  +   +    A+ +A G+ YLH   I   I+RDLK  N+L
Sbjct: 166  LVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNIL 223

Query: 1640 LFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696
            +     N  +   I KI D+G+A+   R    ++ GT  + APEV R + ++++ +DV+S
Sbjct: 224  ILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRAS-MFSKGSDVWS 282

Query: 1697 FGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLK 1754
            +G+LL+++LT     R ++GL             KL  P+      P P   KL++ C  
Sbjct: 283  YGVLLWELLTGEVPFRGIDGLAVAYGV----AMNKLALPIP--STCPEPFA-KLMEDCWN 335

Query: 1755 ENPQERPTSAQVFDILNSAE 1774
             +P  RP+   + D L + E
Sbjct: 336  PDPHSRPSFTNILDQLTTIE 355



>gi|21450844|ref|NP_647611.1|   megakaryocyte-associated tyrosine kinase isoform c [Homo sapiens]
 gi|57997093|emb|CAB70906.2|   hypothetical protein [Homo sapiens]
          Length = 466

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 55/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VME  SKG+L   L+    +L  T Q  + +LHVA+G+ YL S  +++RDL   N+L+ 
Sbjct: 261  IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 319

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
                +  ++AK++D+G+A+   R G+ +S     + APE  +    +  ++DV+SFG+LL
Sbjct: 320  ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 373

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            +++ + G      +      + +E   ++  P    GC P P V  L+  C +  P  RP
Sbjct: 374  WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 428



>gi|21450846|ref|NP_647612.1|   megakaryocyte-associated tyrosine kinase isoform a [Homo sapiens]
 gi|12652729|gb|AAH00114.1|   Megakaryocyte-associated tyrosine kinase, isoform a [Homo sapiens]
 gi|13111883|gb|AAH03109.1|   Megakaryocyte-associated tyrosine kinase, isoform a [Homo sapiens]
 gi|896220|gb|AAC60645.1|   megakaryocyte-associated tyrosine kinase [Homo sapiens]
 gi|1082751|pir||A55625   protein-tyrosine kinase (EC 2.7.1.112) matk, short splice form -
            human
 gi|3702304|gb|AAC62843.1|   MATK_HUMAN; TYROSINE-PROTEIN KINASE CTK; PROTEIN KINASE HYL;
            HEMATOPOIETIC CONSENSUS TYROSINE-LACKING KINASE [Homo
            sapiens]
 gi|1169123|sp|P42679|MATK_HUMAN   Megakaryocyte-associated tyrosine-protein kinase (Tyrosine-protein
            kinase CTK) (Protein kinase HYL) (Hematopoietic consensus
            tyrosine-lacking kinase)
 gi|557272|emb|CAA54493.1|   HYL tyrosine kinase [Homo sapiens]
          Length = 507

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 55/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VME  SKG+L   L+    +L  T Q  + +LHVA+G+ YL S  +++RDL   N+L+ 
Sbjct: 302  IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 360

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
                +  ++AK++D+G+A+   R G+ +S     + APE  +    +  ++DV+SFG+LL
Sbjct: 361  ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 414

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            +++ + G      +      + +E   ++  P    GC P P V  L+  C +  P  RP
Sbjct: 415  WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 469



>gi|21450842|ref|NP_002369.2|   megakaryocyte-associated tyrosine kinase isoform b [Homo sapiens]
          Length = 508

 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 55/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VME  SKG+L   L+    +L  T Q  + +LHVA+G+ YL S  +++RDL   N+L+ 
Sbjct: 303  IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 361

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
                +  ++AK++D+G+A+   R G+ +S     + APE  +    +  ++DV+SFG+LL
Sbjct: 362  ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 415

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            +++ + G      +      + +E   ++  P    GC P P V  L+  C +  P  RP
Sbjct: 416  WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 470



>gi|559594|gb|AAB30995.1|   leukocyte carboxyl-terminal src kinase related gene [Homo sapiens]
          Length = 465

 Score = 77.0 bits (188), Expect = 4e-13
 Identities = 54/180 (30%), Positives = 96/180 (53%), Gaps = 13/180 (7%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VME  SKG+L   L+    +L  T Q  + +LHV +G+ YL S  +++RDL   N+L+ 
Sbjct: 260  IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVREGMEYLESKKLVHRDLAARNILV- 318

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
                +  ++AK++D+G+A+   R G+ +S     + APE  +    +  ++DV+SFG+LL
Sbjct: 319  ----SEELVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVLL 372

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            +++ + G      +      + +E + ++  P    GC P P V  L+  C +  P  RP
Sbjct: 373  WEVFSYGRAPYPKMSLKEVSEAVEKRYRMEPP---EGC-PGP-VHVLMSSCWEAEPARRP 427



>gi|14916455|ref|NP_149117.1|   protein serine kinase H2 [Homo sapiens]
 gi|14346040|gb|AAK59985.1|   serine/threonine kinase PSKH2 [Homo sapiens]
          Length = 385

 Score = 75.5 bits (184), Expect = 1e-12
 Identities = 60/172 (34%), Positives = 87/172 (50%), Gaps = 16/172 (9%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VMELA+ G L DRL+ Q   S T     RI   VADG+RYLH+  I +R+LKP N+L +
Sbjct: 135  MVMELATGGELFDRLIAQ--GSFTERDAVRILQMVADGIRYLHALQITHRNLKPENLLYY 192

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG---IKTSEGTPGFRAPEVARGNVIYNQQADVYSFG 1698
              +P       I D+G+A    + G   +KT  GTP + APEV      Y    D+++ G
Sbjct: 193  --HPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKP-YTSAVDMWALG 249

Query: 1699 LLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++ Y +L+        L F +E  +  +  K+      Y   PWP +  L K
Sbjct: 250  VITYALLS------GFLPFDDE-SQTRLYRKILKGKYNYTGEPWPSISHLAK 294



>gi|55958775|emb|CAI16469.1|   fyn-related kinase [Homo sapiens]
 gi|56203498|emb|CAB87592.2|   fyn-related kinase [Homo sapiens]
 gi|4503787|ref|NP_002022.1|   fyn-related kinase [Homo sapiens]
 gi|15277744|gb|AAH12916.1|   Fyn-related kinase [Homo sapiens]
 gi|2117802|pir||I38396   protein-tyrosine kinase (EC 2.7.1.112) FRK - human
 gi|1169745|sp|P42685|FRK_HUMAN   Tyrosine-protein kinase FRK (Nuclear tyrosine protein kinase RAK)
 gi|741031|prf||2006289A   src-like Tyr kinase
 gi|392888|gb|AAA18284.1|   SRC-like tyrosine kinase
          Length = 505

 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 64/193 (33%), Positives = 90/193 (46%), Gaps = 24/193 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  ++ EL   GSL   LQ D  S +  T Q  +A  VA G+ YL S   I+RDL   NV
Sbjct: 301  PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 360

Query: 1639 LLFTLYPNAAIIAKIADYGIAQ---------YCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            L+         I K+AD+G+A+         Y  R  IK       + APE  R N  ++
Sbjct: 361  LV-----GEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK---WTAPEAIRSNK-FS 411

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LLY+I+T G     G+        L    +LP P     C        ++
Sbjct: 412  IKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP---SNCP--QQFYNIM 466

Query: 1750 KQCLKENPQERPT 1762
             +C    P+ERPT
Sbjct: 467  LECWNAEPKERPT 479



>gi|54696178|gb|AAV38461.1|   mitogen-activated protein kinase kinase kinase 7 [Homo sapiens]
          Length = 606

 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 63/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630
            A + P  LVME A  GSL  +L   +     T  H ++  L  + G+ YLHS     +I+
Sbjct: 95   ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RDLKP N+LL         + KI D+G A  C  +  +  ++G+  + APEV  G+  YN
Sbjct: 155  RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YN 207

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739
            ++ DV+S+G++L++++T              FDE+             G  P  +K    
Sbjct: 208  EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254

Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770
             P P +E L+ +C  ++P +RP+  ++  I+
Sbjct: 255  LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284



>gi|732528|gb|AAC50116.1|   Rak
          Length = 505

 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 64/193 (33%), Positives = 90/193 (46%), Gaps = 24/193 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  ++ EL   GSL   LQ D  S +  T Q  +A  VA G+ YL S   I+RDL   NV
Sbjct: 301  PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV 360

Query: 1639 LLFTLYPNAAIIAKIADYGIAQ---------YCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            L+         I K+AD+G+A+         Y  R  IK       + APE  R N  ++
Sbjct: 361  LV-----GEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK---WTAPEAIRSNK-FS 411

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LLY+I+T G     G+        L    +LP P     C        ++
Sbjct: 412  IKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP---SNCP--QQFYNIM 466

Query: 1750 KQCLKENPQERPT 1762
             +C    P+ERPT
Sbjct: 467  LECWNAEPKERPT 479



>gi|29124496|gb|AAH48960.1|   Viral oncogene yes-1 homolog 1 [Homo sapiens]
 gi|4885661|ref|NP_005424.1|   viral oncogene yes-1 homolog 1 [Homo sapiens]
 gi|66799|pir||TVHUYS   protein-tyrosine kinase (EC 2.7.1.112) yes-1 - human
 gi|125870|sp|P07947|YES_HUMAN   Proto-oncogene tyrosine-protein kinase YES (p61-YES) (C-YES)
 gi|181268|gb|AAA35735.1|   cellular yes-1 protein
          Length = 543

 Score = 74.3 bits (181), Expect = 3e-12
 Identities = 67/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%)

Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597
            T+    + P+  L +      L +D+L     P + +    P  +V E  SKGSL D L 
Sbjct: 306  TLKPGTMMPEAFLQEAQIMKKLRHDKL----VPLYAVVSEEPIYIVTEFMSKGSLLDFLK 361

Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657
            + D   L       +A  +ADG+ Y+     I+RDL+  N+L+        ++ KIAD+G
Sbjct: 362  EGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILV-----GENLVCKIADFG 416

Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708
            +A      +Y  R G K       + APE A    +Y +   ++DV+SFG+L  +++T G
Sbjct: 417  LARLIEDNEYTARQGAKF---PIKWTAPEAA----LYGRFTIKSDVWSFGILQTELVTKG 469

Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
                 G+      +++E   ++P P    GC     + +L+  C K++P ERPT
Sbjct: 470  RVPYPGMVNREVLEQVERGYRMPCP---QGCP--ESLHELMNLCWKKDPDERPT 518



>gi|1082750|pir||A49865   protein-tyrosine kinase (EC 2.7.1.112) matk, long splice form - human
 gi|459550|gb|AAA16703.1|   tyrosine kinase
          Length = 527

 Score = 73.9 bits (180), Expect = 3e-12
 Identities = 55/183 (30%), Positives = 96/183 (52%), Gaps = 14/183 (7%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VME  SKG+L   L+    +L  T Q  + +LHVA+G+ YL S  +++RDL   N+L+ 
Sbjct: 302  IVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV- 360

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
                +  ++AK++D+G+A+   R G+ +S     + APE  +    +  ++DV+SFG+LL
Sbjct: 361  ----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHG--FTSKSDVWSFGVLL 413

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            +++ + G      +      + +E   ++  P    GC P P V  L+  C +  P    
Sbjct: 414  WEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPPAGH 468

Query: 1762 TSA 1764
             SA
Sbjct: 469  PSA 471



>gi|2392699|pdb|2HCK|B   Chain B, Src Family Kinase Hck-Quercetin Complex
 gi|2392698|pdb|2HCK|A   Chain A, Src Family Kinase Hck-Quercetin Complex
 gi|2194104|pdb|1AD5|B   Chain B, Src Family Kinase Hck-Amp-Pnp Complex
 gi|2194103|pdb|1AD5|A   Chain A, Src Family Kinase Hck-Amp-Pnp Complex
          Length = 438

 Score = 73.9 bits (180), Expect = 3e-12
 Identities = 55/195 (28%), Positives = 99/195 (50%), Gaps = 23/195 (11%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 250  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 307

Query: 1637 NVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYS 1696
            N+L+     +A+++ KIAD+G+A+   +  IK       + APE       +  ++DV+S
Sbjct: 308  NILV-----SASLVCKIADFGLARVGAKFPIK-------WTAPEAINFGS-FTIKSDVWS 354

Query: 1697 FGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKEN 1756
            FG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ +C K  
Sbjct: 355  FGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMMRCWKNR 409

Query: 1757 PQERPTSAQVFDILN 1771
            P+ERPT   +  +L+
Sbjct: 410  PEERPTFEYIQSVLD 424



>gi|7981277|emb|CAB91984.1|   protein serine kinase [Homo sapiens]
 gi|38511462|gb|AAH62616.1|   Protein serine kinase H1 [Homo sapiens]
 gi|27901803|ref|NP_006733.1|   protein serine kinase H1 [Homo sapiens]
 gi|17379144|sp|P11801|KPSH1_HUMAN   Serine/threonine-protein kinase H1 (PSK-H1)
          Length = 424

 Score = 73.6 bits (179), Expect = 4e-12
 Identities = 66/192 (34%), Positives = 98/192 (51%), Gaps = 22/192 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VMELA+ G L DR++   K S T     R+   V DG+RYLH+  I +RDLKP N+L +
Sbjct: 170  MVMELATGGELFDRIIA--KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYY 227

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG----IKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697
                ++ II  I D+G+A    + G    +KT+ GTP + APEV      Y    D+++ 
Sbjct: 228  HPGTDSKII--ITDFGLAS-ARKKGDDCLMKTTCGTPEYIAPEVLVRKP-YTNSVDMWAL 283

Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK----QCL 1753
            G++ Y IL +G    E       + ++ ++GK       Y   PWP V  L K    + L
Sbjct: 284  GVIAY-ILLSGTMPFEDDNRTRLYRQI-LRGKY-----SYSGEPWPSVSNLAKDFIDRLL 336

Query: 1754 KENPQERPTSAQ 1765
              +P  R T+ Q
Sbjct: 337  TVDPGARMTALQ 348



>gi|56204061|emb|CAI23531.1|   MAP3K7 [Homo sapiens]
 gi|56203689|emb|CAI19609.1|   MAP3K7 [Homo sapiens]
 gi|21735566|ref|NP_663306.1|   mitogen-activated protein kinase kinase kinase 7 isoform D [Homo
            sapiens]
 gi|6746615|gb|AAF27652.1|   TGF beta-activated kinase splice variant d [Homo sapiens]
          Length = 491

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630
            A + P  LVME A  GSL  +L   +     T  H ++  L  + G+ YLHS     +I+
Sbjct: 95   ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RDLKP N+LL         + KI D+G A  C  +  +  ++G+  + APEV  G+  Y+
Sbjct: 155  RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739
            ++ DV+S+G++L++++T              FDE+             G  P  +K    
Sbjct: 208  EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254

Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770
             P P +E L+ +C  ++P +RP+  ++  I+
Sbjct: 255  LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284



>gi|56204060|emb|CAI23530.1|   MAP3K7 [Homo sapiens]
 gi|56203690|emb|CAI19610.1|   MAP3K7 [Homo sapiens]
 gi|21735564|ref|NP_663305.1|   mitogen-activated protein kinase kinase kinase 7 isoform C [Homo
            sapiens]
 gi|8978252|dbj|BAA25027.2|   TGF-beta activated kinase 1c [Homo sapiens]
          Length = 518

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630
            A + P  LVME A  GSL  +L   +     T  H ++  L  + G+ YLHS     +I+
Sbjct: 95   ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RDLKP N+LL         + KI D+G A  C  +  +  ++G+  + APEV  G+  Y+
Sbjct: 155  RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739
            ++ DV+S+G++L++++T              FDE+             G  P  +K    
Sbjct: 208  EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254

Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770
             P P +E L+ +C  ++P +RP+  ++  I+
Sbjct: 255  LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284



>gi|56204062|emb|CAI23532.1|   MAP3K7 [Homo sapiens]
 gi|56203692|emb|CAI19612.1|   MAP3K7 [Homo sapiens]
 gi|21735562|ref|NP_663304.1|   mitogen-activated protein kinase kinase kinase 7 isoform B [Homo
            sapiens]
 gi|7513396|pir||JC5956   transforming growth factor-beta activated kinase (EC 2.7.-.-) 1b -
            human
 gi|12643557|sp|O43318|M3K7_HUMAN   Mitogen-activated protein kinase kinase kinase 7 (Transforming growth
            factor-beta-activated kinase 1) (TGF-beta-activated
            kinase 1)
 gi|2924626|dbj|BAA25026.1|   TGF-beta activated kinase 1b [Homo sapiens]
          Length = 606

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630
            A + P  LVME A  GSL  +L   +     T  H ++  L  + G+ YLHS     +I+
Sbjct: 95   ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RDLKP N+LL         + KI D+G A  C  +  +  ++G+  + APEV  G+  Y+
Sbjct: 155  RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739
            ++ DV+S+G++L++++T              FDE+             G  P  +K    
Sbjct: 208  EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254

Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770
             P P +E L+ +C  ++P +RP+  ++  I+
Sbjct: 255  LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284



>gi|56204063|emb|CAI23533.1|   MAP3K7 [Homo sapiens]
 gi|56203691|emb|CAI19611.1|   MAP3K7 [Homo sapiens]
 gi|4507361|ref|NP_003179.1|   mitogen-activated protein kinase kinase kinase 7 isoform A [Homo
            sapiens]
 gi|17389343|gb|AAH17715.1|   Mitogen-activated protein kinase kinase kinase 7, isoform A [Homo
            sapiens]
 gi|7513395|pir||JC5955   transforming growth factor-beta activated kinase (EC 2.7.-.-) 1a -
            human
 gi|2924624|dbj|BAA25025.1|   TGF-beta activated kinase 1a [Homo sapiens]
          Length = 579

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630
            A + P  LVME A  GSL  +L   +     T  H ++  L  + G+ YLHS     +I+
Sbjct: 95   ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RDLKP N+LL         + KI D+G A  C  +  +  ++G+  + APEV  G+  Y+
Sbjct: 155  RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739
            ++ DV+S+G++L++++T              FDE+             G  P  +K    
Sbjct: 208  EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254

Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770
             P P +E L+ +C  ++P +RP+  ++  I+
Sbjct: 255  LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284



>gi|54696176|gb|AAV38460.1|   mitogen-activated protein kinase kinase kinase 7 [Homo sapiens]
          Length = 579

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630
            A + P  LVME A  GSL  +L   +     T  H ++  L  + G+ YLHS     +I+
Sbjct: 95   ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RDLKP N+LL         + KI D+G A  C  +  +  ++G+  + APEV  G+  Y+
Sbjct: 155  RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739
            ++ DV+S+G++L++++T              FDE+             G  P  +K    
Sbjct: 208  EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254

Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770
             P P +E L+ +C  ++P +RP+  ++  I+
Sbjct: 255  LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284



>gi|4507277|ref|NP_003148.1|   NIMA (never in mitosis gene a)-related kinase 4 [Homo sapiens]
 gi|7427997|pir||I78885   serine/threonine-specific protein kinase (EC 2.7.1.-) STK2 - human
 gi|1709347|sp|P51957|NEK4_HUMAN   Serine/threonine-protein kinase Nek4 (NimA-related protein kinase 4)
            (Serine/threonine-protein kinase 2)
            (Serine/threonine-protein kinase NRK2)
 gi|348245|gb|AAA36658.1|   protein serine/threonine kinase
          Length = 841

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 17/184 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VM     G L R L++ K  L    Q     + +A  L+YLH   I++RDLK  NV L 
Sbjct: 81   IVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFL- 139

Query: 1642 TLYPNAAIIAKIADYGIAQYC---CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFG 1698
                    I K+ D GIA+     C M   T  GTP + +PE+   N  YN ++DV++ G
Sbjct: 140  ----TRTNIIKVGDLGIARVLENHCDMA-STLIGTPYYMSPELF-SNKPYNYKSDVWALG 193

Query: 1699 LLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
              +Y++ T   +     K  N      I+GKLP   ++Y     P + +LI+  L + P+
Sbjct: 194  CCVYEMATL--KHAFNAKDMNSLVYRIIEGKLPAMPRDYS----PELAELIRTMLSKRPE 247

Query: 1759 ERPT 1762
            ERP+
Sbjct: 248  ERPS 251



>gi|7513397|pir||JC5957   transforming growth factor-beta activated kinase (EC 2.7.-.-) 1c -
            human
          Length = 567

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 37/211 (17%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYLHSAM---IIY 1630
            A + P  LVME A  GSL  +L   +     T  H ++  L  + G+ YLHS     +I+
Sbjct: 95   ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIH 154

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RDLKP N+LL         + KI D+G A  C  +  +  ++G+  + APEV  G+  Y+
Sbjct: 155  RDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAPEVFEGSN-YS 207

Query: 1690 QQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGKLPDPVKEYGC 1739
            ++ DV+S+G++L++++T              FDE+             G  P  +K    
Sbjct: 208  EKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGTRPPLIKN--- 254

Query: 1740 APWPMVEKLIKQCLKENPQERPTSAQVFDIL 1770
             P P +E L+ +C  ++P +RP+  ++  I+
Sbjct: 255  LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284



>gi|38648684|gb|AAH63044.1|   NEK4 protein [Homo sapiens]
          Length = 781

 Score = 73.2 bits (178), Expect = 6e-12
 Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 17/184 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VM     G L R L++ K  L    Q     + +A  L+YLH   I++RDLK  NV L 
Sbjct: 81   IVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFL- 139

Query: 1642 TLYPNAAIIAKIADYGIAQYC---CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFG 1698
                    I K+ D GIA+     C M   T  GTP + +PE+   N  YN ++DV++ G
Sbjct: 140  ----TRTNIIKVGDLGIARVLENHCDMA-STLIGTPYYMSPELF-SNKPYNYKSDVWALG 193

Query: 1699 LLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
              +Y++ T   +     K  N      I+GKLP   ++Y     P + +LI+  L + P+
Sbjct: 194  CCVYEMATL--KHAFNAKDMNSLVYRIIEGKLPAMPRDYS----PELAELIRTMLSKRPE 247

Query: 1759 ERPT 1762
            ERP+
Sbjct: 248  ERPS 251



>gi|56462535|emb|CAI16055.1|   TEK tyrosine kinase, endothelial (venous malformations, multiple
            cutaneous and mucosal) [Homo sapiens]
          Length = 1124

 Score = 72.8 bits (177), Expect = 7e-12
 Identities = 64/205 (31%), Positives = 102/205 (49%), Gaps = 27/205 (13%)

Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627
            L +E A  G+L       R+L+ D A     S   TL  +  LH    VA G+ YL    
Sbjct: 900  LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 959

Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686
             I+RDL   N+L+   Y     +AKIAD+G+++    + +K + G    R   +   N  
Sbjct: 960  FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 1013

Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746
            +Y   +DV+S+G+LL++I++ GG    G+     +++L    +L  P+    C     V 
Sbjct: 1014 VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 1068

Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771
             L++QC +E P ERP+ AQ+   LN
Sbjct: 1069 DLMRQCWREKPYERPSFAQILVSLN 1093



>gi|4557869|ref|NP_000450.1|   TEK tyrosine kinase, endothelial [Homo sapiens]
 gi|2136092|pir||I58388   protein-tyrosine kinase (EC 2.7.1.112), receptor type tek precursor -
            human
 gi|464868|sp|Q02763|TIE2_HUMAN   Angiopoietin 1 receptor precursor (Tyrosine-protein kinase receptor
            TIE-2) (Tyrosine-protein kinase receptor TEK) (P140 TEK)
            (Tunica interna endothelial cell kinase) (CD202b antigen)
 gi|292824|gb|AAA61139.1|   receptor protein-tyrosine kinase
          Length = 1124

 Score = 72.8 bits (177), Expect = 7e-12
 Identities = 64/205 (31%), Positives = 102/205 (49%), Gaps = 27/205 (13%)

Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627
            L +E A  G+L       R+L+ D A     S   TL  +  LH    VA G+ YL    
Sbjct: 900  LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 959

Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686
             I+RDL   N+L+   Y     +AKIAD+G+++    + +K + G    R   +   N  
Sbjct: 960  FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 1013

Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746
            +Y   +DV+S+G+LL++I++ GG    G+     +++L    +L  P+    C     V 
Sbjct: 1014 VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 1068

Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771
             L++QC +E P ERP+ AQ+   LN
Sbjct: 1069 DLMRQCWREKPYERPSFAQILVSLN 1093



>gi|15988251|pdb|1FVR|B   Chain B, Tie2 Kinase Domain
 gi|15988250|pdb|1FVR|A   Chain A, Tie2 Kinase Domain
          Length = 327

 Score = 72.8 bits (177), Expect = 7e-12
 Identities = 64/205 (31%), Positives = 102/205 (49%), Gaps = 27/205 (13%)

Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627
            L +E A  G+L       R+L+ D A     S   TL  +  LH    VA G+ YL    
Sbjct: 103  LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQ 162

Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686
             I+RDL   N+L+   Y     +AKIAD+G+++    + +K + G    R   +   N  
Sbjct: 163  FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 216

Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746
            +Y   +DV+S+G+LL++I++ GG    G+     +++L    +L  P+    C     V 
Sbjct: 217  VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 271

Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771
             L++QC +E P ERP+ AQ+   LN
Sbjct: 272  DLMRQCWREKPYERPSFAQILVSLN 296



>gi|47524177|ref|NP_075252.2|   fibroblast growth factor receptor 4 isoform 2 precursor [Homo
            sapiens]
          Length = 762

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+                 +  L+  +    A  VA G++YL 
Sbjct: 505  PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 564

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KTS G    +  APE
Sbjct: 565  SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L    ++  P     C 
Sbjct: 620  -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 675

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775
              P +  L+++C    P +RPT  Q+ + L+   L
Sbjct: 676  --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 708



>gi|21595367|gb|AAH32413.1|   B lymphoid tyrosine kinase [Homo sapiens]
 gi|33469982|ref|NP_001706.2|   B lymphoid tyrosine kinase [Homo sapiens]
 gi|13938455|gb|AAH07371.1|   B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 60/201 (29%), Positives = 99/201 (49%), Gaps = 27/201 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  +V E  ++G L   L+ D+ S   L R +   ++  +A+G+ Y+     I+RDL+  
Sbjct: 307  PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID--MSAQIAEGMAYIERMNSIHRDLRAA 364

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA-----QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691
            N+L+     + A+  KIAD+G+A     +Y  + G K       + APE     V +  +
Sbjct: 365  NILV-----SEALCCKIADFGLARIIDSEYTAQEGAKFPIK---WTAPEAIHFGV-FTIK 415

Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751
            ADV+SFG+LL +++T G     G+  P     LE   ++P P       P  +   +I +
Sbjct: 416  ADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRP----DTCPPELYRGVIAE 471

Query: 1752 CLKENPQERPTSAQVFDILNS 1772
            C +  P+ERPT    F+ L S
Sbjct: 472  CWRSRPEERPT----FEFLQS 488



>gi|15080148|gb|AAH11847.1|   Fibroblast growth factor receptor 4, isoform 1 precursor [Homo
            sapiens]
 gi|47524175|ref|NP_998812.1|   fibroblast growth factor receptor 4 isoform 1 precursor [Homo
            sapiens]
 gi|47524173|ref|NP_002002.3|   fibroblast growth factor receptor 4 isoform 1 precursor [Homo
            sapiens]
 gi|182571|gb|AAB59389.1|   fibroblast growth factor receptor 4
 gi|298629|gb|AAB25788.1|   fibroblast growth factor receptor 4, FGFR4=transmembrane tyrosine
            kinase receptor [human, mammary epithelial cell line
            B5/589, Peptide, 802 aa]
 gi|13432140|sp|P22455|FGFR4_HUMAN   Fibroblast growth factor receptor 4 precursor (FGFR-4)
          Length = 802

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+                 +  L+  +    A  VA G++YL 
Sbjct: 545  PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KTS G    +  APE
Sbjct: 605  SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L    ++  P     C 
Sbjct: 660  -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775
              P +  L+++C    P +RPT  Q+ + L+   L
Sbjct: 716  --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748



>gi|476558|pir||TVHUF4   fibroblast growth factor receptor 4 precursor - human
 gi|31372|emb|CAA40490.1|   fibroblast growth factor receptor [Homo sapiens]
          Length = 802

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+                 +  L+  +    A  VA G++YL 
Sbjct: 545  PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KTS G    +  APE
Sbjct: 605  SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L    ++  P     C 
Sbjct: 660  -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775
              P +  L+++C    P +RPT  Q+ + L+   L
Sbjct: 716  --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748



>gi|23273968|gb|AAH35514.1|   TEK protein [Homo sapiens]
          Length = 1101

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/205 (31%), Positives = 101/205 (49%), Gaps = 27/205 (13%)

Query: 1583 LVMELASKGSL------DRLLQQDKA-----SLTRTLQHRIALH----VADGLRYLHSAM 1627
            L +E A  G+L       R+L+ D A     S   TL     LH    VA G+ YL    
Sbjct: 877  LAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSHHLLHFAADVARGMDYLSQKQ 936

Query: 1628 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV- 1686
             I+RDL   N+L+   Y     +AKIAD+G+++    + +K + G    R   +   N  
Sbjct: 937  FIHRDLAARNILVGENY-----VAKIADFGLSRGQ-EVYVKKTMGRLPVRWMAIESLNYS 990

Query: 1687 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746
            +Y   +DV+S+G+LL++I++ GG    G+     +++L    +L  P+    C     V 
Sbjct: 991  VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL---NCD--DEVY 1045

Query: 1747 KLIKQCLKENPQERPTSAQVFDILN 1771
             L++QC +E P ERP+ AQ+   LN
Sbjct: 1046 DLMRQCWREKPYERPSFAQILVSLN 1070



>gi|20153207|gb|AAM13666.1|   fibroblast growth factor receptor 4 [Homo sapiens]
          Length = 802

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+                 +  L+  +    A  VA G++YL 
Sbjct: 545  PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KTS G    +  APE
Sbjct: 605  SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L    ++  P     C 
Sbjct: 660  -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775
              P +  L+++C    P +RPT  Q+ + L+   L
Sbjct: 716  --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748



>gi|18250298|ref|NP_543013.1|   src-related kinase lacking C-terminal regulatory tyrosine and
            N-terminal myristylation sites [Homo sapiens]
 gi|27805732|sp|Q9H3Y6|SRMS_HUMAN   Tyrosine-protein kinase Srms
 gi|11137518|emb|CAC15526.1|   dJ697K14.1 (novel tyrosine kinase) [Homo sapiens]
          Length = 488

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 58/201 (28%), Positives = 100/201 (49%), Gaps = 15/201 (7%)

Query: 1576 AGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHR-IALHVADGLRYLHSAMIIYRDLK 1634
            +G  P  +V EL  KG+L   L   +    R       A  VA+G+ YL    +++RDL 
Sbjct: 293  SGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLA 352

Query: 1635 PHNVLLFTLYPNAAIIAKIADYGIAQYC---CRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691
              NVL+     +  +  K+AD+G+A+           +S+    + APE A   V ++Q+
Sbjct: 353  ARNVLV-----DDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRV-FSQK 406

Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751
            +DV+SFG+LL+++ T G    EG+       ++    +LP P      A    V  L+ +
Sbjct: 407  SDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRP-----AACPAEVYVLMLE 461

Query: 1752 CLKENPQERPTSAQVFDILNS 1772
            C + +P+ERP+ A + + L++
Sbjct: 462  CWRSSPEERPSFATLREKLHA 482



>gi|13991618|gb|AAK51435.1|   fibroblast growth factor receptor 4 variant [Homo sapiens]
          Length = 592

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+                 +  L+  +    A  VA G++YL 
Sbjct: 335  PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 394

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KTS G    +  APE
Sbjct: 395  SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 449

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L    ++  P     C 
Sbjct: 450  -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 505

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775
              P +  L+++C    P +RPT  Q+ + L+   L
Sbjct: 506  --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 538



>gi|6739818|gb|AAF27432.1|   fibroblast growth factor receptor 4, soluble-form splice variant
            [Homo sapiens]
          Length = 762

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+                 +  L+  +    A  VA G++YL 
Sbjct: 505  PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 564

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KTS G    +  APE
Sbjct: 565  SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L    ++  P     C 
Sbjct: 620  -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 675

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775
              P +  L+++C    P +RPT  Q+ + L+   L
Sbjct: 676  --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 708



>gi|2117797|pir||I37206   protein-tyrosine kinase (EC 2.7.1.112) blk - human
 gi|601952|emb|CAA83965.1|   Protein-Tyrosine Kinase [Homo sapiens]
 gi|1705485|sp|P51451|BLK_HUMAN   Tyrosine-protein kinase BLK (B lymphocyte kinase) (p55-BLK)
          Length = 505

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 60/201 (29%), Positives = 99/201 (49%), Gaps = 27/201 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  +V E  ++G L   L+ D+ S   L R +   ++  +A+G+ Y+     I+RDL+  
Sbjct: 307  PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID--MSAQIAEGMAYIERMNSIHRDLRAA 364

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA-----QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691
            N+L+     + A+  KIAD+G+A     +Y  + G K       + APE     V +  +
Sbjct: 365  NILV-----SEALCCKIADFGLARIIDSEYTAQEGAKFPIK---WTAPEAIHFGV-FTIK 415

Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751
            ADV+SFG+LL +++T G     G+  P     LE   ++P P       P  +   +I +
Sbjct: 416  ADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRP----DTCPPELYRGVIAE 471

Query: 1752 CLKENPQERPTSAQVFDILNS 1772
            C +  P+ERPT    F+ L S
Sbjct: 472  CWRSRPEERPT----FEFLQS 488



>gi|2832350|emb|CAA74200.1|   fibroblast growth factor 4 [Homo sapiens]
          Length = 802

 Score = 72.4 bits (176), Expect = 1e-11
 Identities = 64/215 (29%), Positives = 101/215 (46%), Gaps = 30/215 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+                 +  L+  +    A  VA G++YL 
Sbjct: 545  PLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLE 604

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KTS G    +  APE
Sbjct: 605  SRKCIHRDLAARNVLV-----TEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 659

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L    ++  P     C 
Sbjct: 660  -ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH---CP 715

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL 1775
              P +  L+++C    P +RPT  Q+ + L+   L
Sbjct: 716  --PELYGLMRECWHAAPSQRPTFKQLVEALDKVLL 748



>gi|21735550|ref|NP_002437.2|   mitogen-activated protein kinase kinase kinase 10 [Homo sapiens]
          Length = 954

 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 30/206 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRI---ALHVADGLRYLHS---AMIIYRDLKPH 1636
            LVME A  G+L R+L        R   H +   A+ VA G+ YLH+     II+RDLK  
Sbjct: 172  LVMEYARGGALSRVLAG-----RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226

Query: 1637 NVLLFTLYPN---AAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 1693
            N+L+     N   A  + KI D+G+A+   +    ++ GT  + APEV R + ++++ +D
Sbjct: 227  NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS-LFSKSSD 285

Query: 1694 VYSFGLLLYDILTTGGRIVEGLKFPNEFDELEI-----QGKLPDPVKEYGCAPWPMVEKL 1748
            V+SFG+LL+++LT       G     E D L +       KL  P+      P P   +L
Sbjct: 286  VWSFGVLLWELLT-------GEVPYREIDALAVAYGVAMNKLTLPIP--STCPEPFA-RL 335

Query: 1749 IKQCLKENPQERPTSAQVFDILNSAE 1774
            +++C   +P  RP    +   L   E
Sbjct: 336  LEECWDPDPHGRPDFGSILKRLEVIE 361



>gi|971420|emb|CAA62351.1|   mixed lineage kinase 2 [Homo sapiens]
 gi|2135747|pir||S68178   mixed-lineage protein kinase 2 (EC 2.7.1.-) - human
 gi|6686295|sp|Q02779|M3K10_HUMAN   Mitogen-activated protein kinase kinase kinase 10 (Mixed lineage
            kinase 2) (Protein kinase MST)
          Length = 954

 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 30/206 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRI---ALHVADGLRYLHS---AMIIYRDLKPH 1636
            LVME A  G+L R+L        R   H +   A+ VA G+ YLH+     II+RDLK  
Sbjct: 172  LVMEYARGGALSRVLAG-----RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226

Query: 1637 NVLLFTLYPN---AAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 1693
            N+L+     N   A  + KI D+G+A+   +    ++ GT  + APEV R + ++++ +D
Sbjct: 227  NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS-LFSKSSD 285

Query: 1694 VYSFGLLLYDILTTGGRIVEGLKFPNEFDELEI-----QGKLPDPVKEYGCAPWPMVEKL 1748
            V+SFG+LL+++LT       G     E D L +       KL  P+      P P   +L
Sbjct: 286  VWSFGVLLWELLT-------GEVPYREIDALAVAYGVAMNKLTLPIP--STCPEPFA-RL 335

Query: 1749 IKQCLKENPQERPTSAQVFDILNSAE 1774
            +++C   +P  RP    +   L   E
Sbjct: 336  LEECWDPDPHGRPDFGSILKRLEVIE 361



>gi|758593|emb|CAA88531.1|   serine/threonine kinase with SH3 domain, leucine zipper domain and
            proline rich domain [Homo sapiens]
          Length = 953

 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 30/206 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRI---ALHVADGLRYLHS---AMIIYRDLKPH 1636
            LVME A  G+L R+L        R   H +   A+ VA G+ YLH+     II+RDLK  
Sbjct: 172  LVMEYARGGALSRVLAG-----RRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226

Query: 1637 NVLLFTLYPN---AAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 1693
            N+L+     N   A  + KI D+G+A+   +    ++ GT  + APEV R + ++++ +D
Sbjct: 227  NILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS-LFSKSSD 285

Query: 1694 VYSFGLLLYDILTTGGRIVEGLKFPNEFDELEI-----QGKLPDPVKEYGCAPWPMVEKL 1748
            V+SFG+LL+++LT       G     E D L +       KL  P+      P P   +L
Sbjct: 286  VWSFGVLLWELLT-------GEVPYREIDALAVAYGVAMNKLTLPIP--STCPEPFA-RL 335

Query: 1749 IKQCLKENPQERPTSAQVFDILNSAE 1774
            +++C   +P  RP    +   L   E
Sbjct: 336  LEECWDPDPHGRPDFGSILKRLEVIE 361



>gi|914204|gb|AAB33265.1|   protein tyrosine kinase [Homo sapiens]
          Length = 505

 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 60/201 (29%), Positives = 99/201 (49%), Gaps = 27/201 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  +V E  ++G L   L+ D+ S   L R +   ++  +A+G+ Y+     I+RDL+  
Sbjct: 307  PIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID--MSAQIAEGMAYIERMNSIHRDLRAA 364

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA-----QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQ 1691
            N+L+     + A+  KIAD+G+A     +Y  + G K       + APE     V +  +
Sbjct: 365  NILV-----SEALCCKIADFGLARIIDSEYTAQEGAKFPIK---WTAPEAYHFGV-FTIK 415

Query: 1692 ADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQ 1751
            ADV+SFG+LL +++T G     G+  P     LE   ++P P       P  +   +I +
Sbjct: 416  ADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRP----DTCPPELYRGVIAE 471

Query: 1752 CLKENPQERPTSAQVFDILNS 1772
            C +  P+ERPT    F+ L S
Sbjct: 472  CWRSRPEERPT----FEFLQS 488



>gi|56203175|emb|CAI22966.1|   HCK [Homo sapiens]
 gi|56205100|emb|CAI19694.1|   HCK [Homo sapiens]
 gi|15680177|gb|AAH14435.1|   Unknown (protein for MGC:22922) [Homo sapiens]
 gi|2144421|pir||TVHUHC   protein-tyrosine kinase (EC 2.7.1.112) hck - human
 gi|306833|gb|AAA52644.1|   protein-tyrosine kinase
          Length = 505

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 307  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 364

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            N+L+     +A+++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 365  NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 415

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ 
Sbjct: 416  KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 470

Query: 1751 QCLKENPQERPTSAQVFDILN 1771
            +C K  P+ERPT   +  +L+
Sbjct: 471  RCWKNRPEERPTFEYIQSVLD 491



>gi|306832|gb|AAA52643.1|   protein-tyrosine kinase
          Length = 505

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 307  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 364

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            N+L+     +A+++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 365  NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 415

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ 
Sbjct: 416  KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 470

Query: 1751 QCLKENPQERPTSAQVFDILN 1771
            +C K  P+ERPT   +  +L+
Sbjct: 471  RCWKNRPEERPTFEYIQSVLD 491



>gi|30795229|ref|NP_002101.2|   hemopoietic cell kinase isoform p61HCK [Homo sapiens]
 gi|20141296|sp|P08631|HCK_HUMAN   Tyrosine-protein kinase HCK (p59-HCK/p60-HCK) (Hemopoietic cell
            kinase)
          Length = 526

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 328  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 385

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            N+L+     +A+++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 386  NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 436

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ 
Sbjct: 437  KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 491

Query: 1751 QCLKENPQERPTSAQVFDILN 1771
            +C K  P+ERPT   +  +L+
Sbjct: 492  RCWKNRPEERPTFEYIQSVLD 512



>gi|56203176|emb|CAI22967.1|   HCK [Homo sapiens]
 gi|56205101|emb|CAI19695.1|   HCK [Homo sapiens]
          Length = 504

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 306  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 363

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            N+L+     +A+++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 364  NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 414

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ 
Sbjct: 415  KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 469

Query: 1751 QCLKENPQERPTSAQVFDILN 1771
            +C K  P+ERPT   +  +L+
Sbjct: 470  RCWKNRPEERPTFEYIQSVLD 490



>gi|10439296|dbj|BAB15482.1|   unnamed protein product [Homo sapiens]
          Length = 505

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 307  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 364

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            N+L+     +A+++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 365  NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 415

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ 
Sbjct: 416  KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 470

Query: 1751 QCLKENPQERPTSAQVFDILN 1771
            +C K  P+ERPT   +  +L+
Sbjct: 471  RCWKNRPEERPTFEYIQSVLD 491



>gi|19923729|ref|NP_115646.2|   hypothetical protein AD158 [Homo sapiens]
 gi|19570360|dbj|BAB86303.1|   AD158 [Homo sapiens]
          Length = 803

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 78/302 (25%), Positives = 140/302 (46%), Gaps = 33/302 (10%)

Query: 741  LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS---RNDIGPSV 797
            L +CS  +   + S   ++L  L +  +     P ++  +  +  L +     +DI  +V
Sbjct: 474  LHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNV 533

Query: 798  VLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKIL 857
             L+      +LK  ++  N +S +P+ + DV   L+++ +  +           K + + 
Sbjct: 534  TLESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGT---------KLVMLN 583

Query: 858  NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
            NL K  +++L+E  L  C       A  + L        S+  L L +N    I E I++
Sbjct: 584  NLKK--MTNLTELELVHCDLERIPHAVFSLL--------SLQELDLKENNLKSIEE-IVS 632

Query: 918  LPHLRSLDMSS---NDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVEKL 973
              HLR L +     N I Y+P   H K L +L  L FSHN+I +L      +L +++  L
Sbjct: 633  FQHLRKLTVLKLWHNSITYIP--EHIKKLTSLERLSFSHNKIEVLP--SHLFLCNKIRYL 688

Query: 974  HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKH 1033
             LS+N ++ IPPEIG L++L    ++ N ++ S P+E+    K+  L + +  L+     
Sbjct: 689  DLSYNDIRFIPPEIGVLQSLQYFSITCN-KVESLPDELYFCKKLKTLKIGKNSLSVLSPK 747

Query: 1034 IG 1035
            IG
Sbjct: 748  IG 749



 Score = 61.6 bits (148), Expect = 2e-08
 Identities = 72/271 (26%), Positives = 117/271 (43%), Gaps = 38/271 (14%)

Query: 752  SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS--------RNDIGPSVVLDPTV 803
            S ++TL+SL   DL S K  S  S + K+   A +DVS         ND    V+L+   
Sbjct: 530  SRNVTLESLR--DLKSLKILSIKSNVSKIPQ-AVVDVSSHLQKMCIHNDGTKLVMLNNLK 586

Query: 804  KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSK 861
            K   L +  L +  L  +P  +  ++   E  + E N   I  I S   L++L +L L  
Sbjct: 587  KMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWH 646

Query: 862  NHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHL 921
            N I+ + E+  +                       S+  L  S NK   +P  +     +
Sbjct: 647  NSITYIPEHIKKLT---------------------SLERLSFSHNKIEVLPSHLFLCNKI 685

Query: 922  RSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981
            R LD+S NDI+++P P      +L+    + N++    L ++ Y   +++ L +  N L 
Sbjct: 686  RYLDLSYNDIRFIP-PEIGVLQSLQYFSITCNKVE--SLPDELYFCKKLKTLKIGKNSLS 742

Query: 982  EIPPEIGCLENLTSLDVSYNLELRSFPNEMG 1012
             + P+IG L  L+ LDV  N      P E+G
Sbjct: 743  VLSPKIGNLLFLSYLDVKGN-HFEILPPELG 772



>gi|50949358|emb|CAB66853.2|   hypothetical protein [Homo sapiens]
          Length = 716

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 78/302 (25%), Positives = 140/302 (46%), Gaps = 33/302 (10%)

Query: 741  LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS---RNDIGPSV 797
            L +CS  +   + S   ++L  L +  +     P ++  +  +  L +     +DI  +V
Sbjct: 387  LHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNV 446

Query: 798  VLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKIL 857
             L+      +LK  ++  N +S +P+ + DV   L+++ +  +           K + + 
Sbjct: 447  TLESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGT---------KLVMLN 496

Query: 858  NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
            NL K  +++L+E  L  C       A  + L        S+  L L +N    I E I++
Sbjct: 497  NLKK--MTNLTELELVHCDLERIPHAVFSLL--------SLQELDLKENNLKSIEE-IVS 545

Query: 918  LPHLRSLDMSS---NDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVEKL 973
              HLR L +     N I Y+P   H K L +L  L FSHN+I +L      +L +++  L
Sbjct: 546  FQHLRKLTVLKLWHNSITYIP--EHIKKLTSLERLSFSHNKIEVLP--SHLFLCNKIRYL 601

Query: 974  HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKH 1033
             LS+N ++ IPPEIG L++L    ++ N ++ S P+E+    K+  L + +  L+     
Sbjct: 602  DLSYNDIRFIPPEIGVLQSLQYFSITCN-KVESLPDELYFCKKLKTLKIGKNSLSVLSPK 660

Query: 1034 IG 1035
            IG
Sbjct: 661  IG 662



 Score = 61.6 bits (148), Expect = 2e-08
 Identities = 72/271 (26%), Positives = 117/271 (43%), Gaps = 38/271 (14%)

Query: 752  SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVS--------RNDIGPSVVLDPTV 803
            S ++TL+SL   DL S K  S  S + K+   A +DVS         ND    V+L+   
Sbjct: 443  SRNVTLESLR--DLKSLKILSIKSNVSKIPQ-AVVDVSSHLQKMCIHNDGTKLVMLNNLK 499

Query: 804  KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGN--KISGICSPLRLKELKILNLSK 861
            K   L +  L +  L  +P  +  ++   E  + E N   I  I S   L++L +L L  
Sbjct: 500  KMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWH 559

Query: 862  NHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHL 921
            N I+ + E+  +                       S+  L  S NK   +P  +     +
Sbjct: 560  NSITYIPEHIKKLT---------------------SLERLSFSHNKIEVLPSHLFLCNKI 598

Query: 922  RSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 981
            R LD+S NDI+++P P      +L+    + N++    L ++ Y   +++ L +  N L 
Sbjct: 599  RYLDLSYNDIRFIP-PEIGVLQSLQYFSITCNKVE--SLPDELYFCKKLKTLKIGKNSLS 655

Query: 982  EIPPEIGCLENLTSLDVSYNLELRSFPNEMG 1012
             + P+IG L  L+ LDV  N      P E+G
Sbjct: 656  VLSPKIGNLLFLSYLDVKGN-HFEILPPELG 685



>gi|5542349|pdb|1QCF|A   Chain A, Crystal Structure Of Hck In Complex With A Src Family-
            Selective Tyrosine Kinase Inhibitor
          Length = 454

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 256  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 313

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            N+L+     +A+++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 314  NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 364

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ 
Sbjct: 365  KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 419

Query: 1751 QCLKENPQERPTSAQVFDILN 1771
            +C K  P+ERPT   +  +L+
Sbjct: 420  RCWKNRPEERPTFEYIQSVLD 440



>gi|5804911|emb|CAA41565.2|   tyrosine kinase [Homo sapiens]
          Length = 348

 Score = 71.6 bits (174), Expect = 2e-11
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 25/201 (12%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D+ S   L + +    +  +A+G+ ++     I+RDL+  
Sbjct: 150  PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID--FSAQIAEGMAFIEQRNYIHRDLRAA 207

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            N+L+     +A+++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 208  NILV-----SASLVCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGS-FTI 258

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LL +I+T G     G+  P     LE   ++P P     C     +  ++ 
Sbjct: 259  KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP---ENCP--EELYNIMM 313

Query: 1751 QCLKENPQERPTSAQVFDILN 1771
            +C K  P+ERPT   +  +L+
Sbjct: 314  RCWKNRPEERPTFEYIQSVLD 334



>gi|56204189|emb|CAI23046.1|   mixed lineage kinase 4 (KIAA1804) [Homo sapiens]
          Length = 1036

 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 62/218 (28%), Positives = 109/218 (50%), Gaps = 29/218 (13%)

Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627
            LV+E A  G+L+R L    A+            R   H +   A+ +A G+ YLH     
Sbjct: 198  LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257

Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683
             I++RDLK  N+LL     +  I     KI D+G+A+   R    ++ GT  + APEV +
Sbjct: 258  PILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317

Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
             + ++++ +D++S+G+LL+++LT     R ++GL         ++   +P         P
Sbjct: 318  SS-LFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
             P   KL+K+C +++P  RP+ A + + L + E   +T
Sbjct: 371  EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407



>gi|4503743|ref|NP_002009.1|   flightless I homolog [Homo sapiens]
 gi|19263700|gb|AAH25300.1|   Flightless I homolog [Homo sapiens]
 gi|2138290|gb|AAC02796.1|   see GenBank Accession Number U01184 for cDNA; similar to Drosophila
            melanogaster fliI in GenBank Accession Number U01182 and
            Caenorhabditis elegans fliI homolog in GenBank Accession
            Number U01183 [Homo sapiens]
 gi|18202493|sp|Q13045|FLII_HUMAN   Flightless-I protein homolog
          Length = 1269

 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 86/307 (28%), Positives = 131/307 (42%), Gaps = 45/307 (14%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            L+ L HL +  N  T+    L  +  +  +    N +  S V D   K   L   +LS+N
Sbjct: 55   LQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHN 114

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPL--RLKELKILNLSKNHISSLSENF--- 871
            QL+  P  L +    L  L L  N I  I + L   L +L  L+LS+N + SL       
Sbjct: 115  QLTECPRELENAKNMLV-LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRL 173

Query: 872  -------LEACPKVESFSARMNFLAAMPFL------------PPSMTILK------LSQN 906
                   L   P + +   ++  + A+  L            P S+  L       LS N
Sbjct: 174  VHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 233

Query: 907  KFSCIPEAILNLPHLRSLDMSSNDIQYL----PGPAHWKSLNLRELLFSHNQISILDLSE 962
              + +PE +  LP LR L++SSN I  L        H ++LNL     S NQ++   L  
Sbjct: 234  DLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL-----SRNQLT--SLPS 286

Query: 963  KAYLWSRVEKLHLSHNKL--KEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020
                 S+++KL+L+ NKL    +P  IG L NL    ++ N  L   P  + +  K+  L
Sbjct: 287  AICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF-MAANNNLELVPESLCRCPKLRKL 345

Query: 1021 PLDELHL 1027
             L++ HL
Sbjct: 346  VLNKNHL 352




 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 55/198 (27%), Positives = 87/198 (43%), Gaps = 31/198 (15%)

Query: 742 QRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLD 800
           QR   NL      L+  +L  +DL  N  T  P  L  +  +  L++S N I   S+ +D
Sbjct: 209 QRTQSNLPTSLEGLS--NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 266

Query: 801 PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKIS--GICSPL-RLKELKIL 857
             V   TL   NLS NQL+ +P  +  +  KL++L L  NK+   G+ S + +L  L+  
Sbjct: 267 QWVHVETL---NLSRNQLTSLPSAICKL-SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322

Query: 858 NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
             + N++  + E+    CPK+                      L L++N    +PEAI  
Sbjct: 323 MAANNNLELVPESLCR-CPKLRK--------------------LVLNKNHLVTLPEAIHF 361

Query: 918 LPHLRSLDMSSNDIQYLP 935
           L  +  LD+  N    +P
Sbjct: 362 LTEIEVLDVRENPNLVMP 379



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 33/116 (28%), Positives = 60/116 (51%), Gaps = 4/116 (3%)

Query: 897  SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQI 955
            S+  LKL++     +PE +  L  L  L +S N++  L G     SL +LR ++   N +
Sbjct: 34   SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGEL--SSLPSLRAIVARANSL 91

Query: 956  SILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEM 1011
                + +  +    +  L LSHN+L E P E+   +N+  L++S+N  + + PN++
Sbjct: 92   KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHN-SIDTIPNQL 146



 Score = 37.7 bits (86), Expect = 0.26
 Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 4/117 (3%)

Query: 913  EAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVE 971
            EA   LP +R +D+S ND +    P + K++ +LR L    N+  +  L E+     ++E
Sbjct: 2    EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKL--NRTGLCYLPEELAALQKLE 59

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYN-LELRSFPNEMGKLSKIWDLPLDELHL 1027
             L +SHN L  +  E+  L +L ++    N L+    P+++ KL  +  L L    L
Sbjct: 60   HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQL 116



>gi|56204188|emb|CAI23045.1|   mixed lineage kinase 4 (KIAA1804) [Homo sapiens]
          Length = 570

 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 62/218 (28%), Positives = 109/218 (50%), Gaps = 29/218 (13%)

Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627
            LV+E A  G+L+R L    A+            R   H +   A+ +A G+ YLH     
Sbjct: 198  LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257

Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683
             I++RDLK  N+LL     +  I     KI D+G+A+   R    ++ GT  + APEV +
Sbjct: 258  PILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317

Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
             + ++++ +D++S+G+LL+++LT     R ++GL         ++   +P         P
Sbjct: 318  SS-LFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
             P   KL+K+C +++P  RP+ A + + L + E   +T
Sbjct: 371  EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407



>gi|2135121|pir||A49674   flightless-I homolog - human (fragment)
 gi|440177|gb|AAC03568.1|   flightless-I homolog [Homo sapiens]
          Length = 1268

 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 86/307 (28%), Positives = 131/307 (42%), Gaps = 45/307 (14%)

Query: 757  LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
            L+ L HL +  N  T+    L  +  +  +    N +  S V D   K   L   +LS+N
Sbjct: 54   LQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHN 113

Query: 817  QLSFVPENLTDVVEKLEQLILEGNKISGICSPL--RLKELKILNLSKNHISSLSENF--- 871
            QL+  P  L +    L  L L  N I  I + L   L +L  L+LS+N + SL       
Sbjct: 114  QLTECPRELENAKNMLV-LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRL 172

Query: 872  -------LEACPKVESFSARMNFLAAMPFL------------PPSMTILK------LSQN 906
                   L   P + +   ++  + A+  L            P S+  L       LS N
Sbjct: 173  VHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 232

Query: 907  KFSCIPEAILNLPHLRSLDMSSNDIQYL----PGPAHWKSLNLRELLFSHNQISILDLSE 962
              + +PE +  LP LR L++SSN I  L        H ++LNL     S NQ++   L  
Sbjct: 233  DLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL-----SRNQLT--SLPS 285

Query: 963  KAYLWSRVEKLHLSHNKL--KEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1020
                 S+++KL+L+ NKL    +P  IG L NL    ++ N  L   P  + +  K+  L
Sbjct: 286  AICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF-MAANNNLELVPESLCRCPKLRKL 344

Query: 1021 PLDELHL 1027
             L++ HL
Sbjct: 345  VLNKNHL 351



 Score = 51.6 bits (122), Expect = 2e-05
 Identities = 55/198 (27%), Positives = 87/198 (43%), Gaps = 31/198 (15%)

Query: 742 QRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLD 800
           QR   NL      L+  +L  +DL  N  T  P  L  +  +  L++S N I   S+ +D
Sbjct: 208 QRTQSNLPTSLEGLS--NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 265

Query: 801 PTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKIS--GICSPL-RLKELKIL 857
             V   TL   NLS NQL+ +P  +  +  KL++L L  NK+   G+ S + +L  L+  
Sbjct: 266 QWVHVETL---NLSRNQLTSLPSAICKL-SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 321

Query: 858 NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
             + N++  + E+    CPK+                      L L++N    +PEAI  
Sbjct: 322 MAANNNLELVPESLCR-CPKLRK--------------------LVLNKNHLVTLPEAIHF 360

Query: 918 LPHLRSLDMSSNDIQYLP 935
           L  +  LD+  N    +P
Sbjct: 361 LTEIEVLDVRENPNLVMP 378



 Score = 45.4 bits (106), Expect = 0.001
 Identities = 33/116 (28%), Positives = 60/116 (51%), Gaps = 4/116 (3%)

Query: 897  SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQI 955
            S+  LKL++     +PE +  L  L  L +S N++  L G     SL +LR ++   N +
Sbjct: 33   SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGEL--SSLPSLRAIVARANSL 90

Query: 956  SILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEM 1011
                + +  +    +  L LSHN+L E P E+   +N+  L++S+N  + + PN++
Sbjct: 91   KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHN-SIDTIPNQL 145



 Score = 37.7 bits (86), Expect = 0.26
 Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 4/117 (3%)

Query: 913  EAILNLPHLRSLDMSSNDIQYLPGPAHWKSL-NLRELLFSHNQISILDLSEKAYLWSRVE 971
            EA   LP +R +D+S ND +    P + K++ +LR L    N+  +  L E+     ++E
Sbjct: 1    EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKL--NRTGLCYLPEELAALQKLE 58

Query: 972  KLHLSHNKLKEIPPEIGCLENLTSLDVSYN-LELRSFPNEMGKLSKIWDLPLDELHL 1027
             L +SHN L  +  E+  L +L ++    N L+    P+++ KL  +  L L    L
Sbjct: 59   HLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQL 115



>gi|5174647|ref|NP_005966.1|   PTK6 protein tyrosine kinase 6 [Homo sapiens]
 gi|1082891|pir||S49016   protein-tyrosine kinase (EC 2.7.1.112) brk - human
 gi|3551753|gb|AAC34935.1|   non-receptor type protein tyrosine kinase [Homo sapiens]
 gi|8928302|sp|Q13882|PTK6_HUMAN   Tyrosine-protein kinase 6 (Breast tumor kinase) (Tyrosine-protein
            kinase brk)
 gi|11137517|emb|CAC15525.1|   dJ697K14.2 (tyrosine kinase) [Homo sapiens]
 gi|515026|emb|CAA55295.1|   tyrosine kinase [Homo sapiens]
          Length = 451

 Score = 70.5 bits (171), Expect = 4e-11
 Identities = 59/197 (29%), Positives = 104/197 (52%), Gaps = 16/197 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQ-DKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  ++ EL +KGSL  LL+  D+  L  +    IA  VA+G+ YL S   I+RDL   N+
Sbjct: 259  PVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNI 318

Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCR-MGIKTSEGTP-GFRAPE-VARGNVIYNQQADVY 1695
            L+         + K+ D+G+A+     + +      P  + APE ++RG+  Y+ ++DV+
Sbjct: 319  LV-----GENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGH--YSTKSDVW 371

Query: 1696 SFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKE 1755
            SFG+LL+++ + G     G+     F  ++   ++P P++   C   P V KL+  C   
Sbjct: 372  SFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLE---CP--PSVHKLMLTCWCR 426

Query: 1756 NPQERPTSAQVFDILNS 1772
            +P++RP    + + L+S
Sbjct: 427  DPEQRPCFKALRERLSS 443



>gi|37181696|gb|AAQ88655.1|   SAPS287 [Homo sapiens]
 gi|40255157|ref|NP_700356.2|   leucine-rich repeats and immunoglobulin-like domains 3 [Homo sapiens]
 gi|41020772|gb|AAR98629.1|   leucine-rich and immunoglobulin-like domains 3 [Homo sapiens]
          Length = 1119

 Score = 70.1 bits (170), Expect = 5e-11
 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 45/274 (16%)

Query: 763  LDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVP 822
            LD    +    P  L   S +A LD+S N +   +         +L++  L+ N+L  +P
Sbjct: 58   LDCSRKRLARLPEPL--PSWVARLDLSHNRLS-FIKASSMSHLQSLREVKLNNNELETIP 114

Query: 823  ENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKNHISSLSENFLEACPKVE 879
             NL  V   +  L L GN+I  I  P  LKE   L+ L+LS N+IS L   F     +++
Sbjct: 115  -NLGPVSANITLLSLAGNRIVEIL-PEHLKEFQSLETLDLSSNNISELQTAF--PALQLK 170

Query: 880  SFSARMNFLAAMP-----FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 934
                  N + +M       L  ++ +LKL++N+ S IP  +  LP L+ L+++ N I+ +
Sbjct: 171  YLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNV 230

Query: 935  PG------------------------PAHWKSLNLRELLFSHNQISILDLSEKAYLWS-- 968
             G                         A W   N+  L   HN ++ +    K +L+   
Sbjct: 231  DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEI---TKGWLYGLL 287

Query: 969  RVEKLHLSHNKLKEIPPEI-GCLENLTSLDVSYN 1001
             +++LHLS N +  I P+     + L+ LD+++N
Sbjct: 288  MLQELHLSQNAINRISPDAWEFCQKLSELDLTFN 321



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 67/286 (23%), Positives = 125/286 (43%), Gaps = 30/286 (10%)

Query: 759  SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818
            +L  L L+ N+ ++ P  + K+  + +L+++RN I  +V          LK   +  N +
Sbjct: 193  TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKI-KNVDGLTFQGLGALKSLKMQRNGV 251

Query: 819  SFVPENLTDVVEKLEQLILEGNKISGICSP--LRLKELKILNLSKNHISSLSENFLEACP 876
            + + +     +  +E L L+ N ++ I       L  L+ L+LS+N I+ +S +  E C 
Sbjct: 252  TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 311

Query: 877  KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
            K+       N L+            +L  + F       L L  L +L + +N + Y+  
Sbjct: 312  KLSELDLTFNHLS------------RLDDSSF-------LGLSLLNTLHIGNNRVSYIAD 352

Query: 937  PAHWKSLNLRELLFSHNQIS--ILDLSEKAYLWSRVEKLHLSHNKLKEIPPE-IGCLENL 993
             A     +L+ L   +N+IS  I D++       ++ +L L  N+++ I  +    L+ L
Sbjct: 353  CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 412

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAK 1039
              LD+S N  +    N   ++ K     L +LHLN       C+ K
Sbjct: 413  EHLDLSDNAIMSLQGNAFSQMKK-----LQQLHLNTSSLLCDCQLK 453



 Score = 33.5 bits (75), Expect = 4.9
 Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 6/106 (5%)

Query: 924  LDMSSNDIQYLPGPA-HWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKE 982
            LD S   +  LP P   W    +  L  SHN++S +  S  ++L S + ++ L++N+L+ 
Sbjct: 58   LDCSRKRLARLPEPLPSW----VARLDLSHNRLSFIKASSMSHLQS-LREVKLNNNELET 112

Query: 983  IPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLN 1028
            IP       N+T L ++ N  +   P  + +   +  L L   +++
Sbjct: 113  IPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS 158



>gi|47458813|ref|NP_006242.4|   protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 1
            [Homo sapiens]
 gi|5410312|gb|AAD43027.1|   AMP-activated kinase alpha 1 subunit [Homo sapiens]
 gi|27469582|gb|AAH37303.1|   PRKAA1 protein [Homo sapiens]
          Length = 550

 Score = 70.1 bits (170), Expect = 5e-11
 Identities = 43/124 (34%), Positives = 69/124 (55%), Gaps = 7/124 (5%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME  S G L   + ++   L      R+   +  G+ Y H  M+++RDLKP NVLL  
Sbjct: 93   MVMEYVSGGELFDYICKN-GRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL-- 149

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
               +A + AKIAD+G++        ++TS G+P + APEV  G +    + D++S G++L
Sbjct: 150  ---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVIL 206

Query: 1702 YDIL 1705
            Y +L
Sbjct: 207  YALL 210



>gi|20178277|sp|Q13131|AAPK1_HUMAN   5'-AMP-activated protein kinase, catalytic alpha-1 chain (AMPK
            alpha-1 chain)
 gi|4115829|dbj|BAA36547.1|   AMP-activated protein kinase alpha-1 [Homo sapiens]
          Length = 550

 Score = 70.1 bits (170), Expect = 5e-11
 Identities = 43/124 (34%), Positives = 69/124 (55%), Gaps = 7/124 (5%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME  S G L   + ++   L      R+   +  G+ Y H  M+++RDLKP NVLL  
Sbjct: 93   MVMEYVSGGELFDYICKN-GRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLL-- 149

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
               +A + AKIAD+G++        ++TS G+P + APEV  G +    + D++S G++L
Sbjct: 150  ---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVIL 206

Query: 1702 YDIL 1705
            Y +L
Sbjct: 207  YALL 210



>gi|50845418|ref|NP_065973.2|   WNK lysine deficient protein kinase 3 isoform 1 [Homo sapiens]
 gi|40738019|gb|AAR89465.1|   putative protein kinase WNK3 [Homo sapiens]
          Length = 1800

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%)

Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624
            + F  + E +L G +  +LV EL + G+L   L++ K    + L+      +  GL++LH
Sbjct: 207  VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265

Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682
            +    II+RDLK  N+  F   P  ++  KI D G+A        K+  GTP F APE+ 
Sbjct: 266  TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321

Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740
              +  Y++  DVY+FG+ + ++ T+         +    +  +I  K+   +K   +   
Sbjct: 322  EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773
              P V+++I+ C+++N  ER     + D+LN A
Sbjct: 374  TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403



>gi|30016945|gb|AAP03432.1|   v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens]
 gi|17390263|gb|AAH18119.1|   V-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens]
 gi|4506401|ref|NP_002871.1|   v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens]
 gi|66762|pir||TVHUF6   protein kinase raf-1 (EC 2.7.1.-) - human
 gi|125651|sp|P04049|RAF1_HUMAN   RAF proto-oncogene serine/threonine-protein kinase (Raf-1) (C-RAF)
            (cRaf)
 gi|35842|emb|CAA27204.1|   unnamed protein product [Homo sapiens]
          Length = 648

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 56/172 (32%), Positives = 92/172 (53%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RD+K +N+ L     +  +  KI D+G+A    R      +
Sbjct: 448  IARQTAQGMDYLHAKNIIHRDMKSNNIFL-----HEGLTVKIGDFGLATVKSRWSGSQQV 502

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R   N  ++ Q+DVYS+G++LY+++ TG      +   ++   + 
Sbjct: 503  EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM-TGELPYSHINNRDQIIFMV 561

Query: 1726 IQG-KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G   PD  K Y   P  M ++L+  C+K+  +ERP   Q   IL+S EL+
Sbjct: 562  GRGYASPDLSKLYKNCPKAM-KRLVADCVKKVKEERPLFPQ---ILSSIELL 609



>gi|4826878|ref|NP_005100.1|   oxidative-stress responsive 1 [Homo sapiens]
 gi|14250548|gb|AAH08726.1|   Oxidative-stress responsive 1 [Homo sapiens]
 gi|4519629|dbj|BAA75674.1|   oxidative-stress responsive 1 [Homo sapiens]
          Length = 527

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 61/205 (29%), Positives = 98/205 (47%), Gaps = 30/205 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKAS-------LTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635
            LVM+L S GS+  +++   A        L  +    I   V +GL YLH    I+RD+K 
Sbjct: 90   LVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKA 149

Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688
             N+LL           +IAD+G++ +    G        KT  GTP + APEV      Y
Sbjct: 150  GNILL-----GEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGY 204

Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
            + +AD++SFG+   ++ T            V  L   N+   LE   +  + +K+YG   
Sbjct: 205  DFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYG--- 261

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766
                 K+I  CL+++P++RPT+A++
Sbjct: 262  -KSFRKMISLCLQKDPEKRPTAAEL 285



>gi|57284054|emb|CAI43129.1|   protein kinase, lysine deficient 3 [Homo sapiens]
 gi|57210008|emb|CAI42733.1|   protein kinase, lysine deficient 3 [Homo sapiens]
 gi|57209550|emb|CAI40708.1|   protein kinase, lysine deficient 3 [Homo sapiens]
 gi|50845416|ref|NP_001002838.1|   WNK lysine deficient protein kinase 3 isoform 2 [Homo sapiens]
 gi|41688792|sp|Q9BYP7|WNK3_HUMAN   Serine/threonine-protein kinase WNK3 (Protein kinase with no lysine
            3) (Protein kinase, lysine-deficient 3)
 gi|19032238|emb|CAC32455.2|   protein kinase WNK3 [Homo sapiens]
          Length = 1743

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%)

Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624
            + F  + E +L G +  +LV EL + G+L   L++ K    + L+      +  GL++LH
Sbjct: 207  VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265

Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682
            +    II+RDLK  N+  F   P  ++  KI D G+A        K+  GTP F APE+ 
Sbjct: 266  TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321

Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740
              +  Y++  DVY+FG+ + ++ T+         +    +  +I  K+   +K   +   
Sbjct: 322  EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773
              P V+++I+ C+++N  ER     + D+LN A
Sbjct: 374  TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403



>gi|57284053|emb|CAI43128.1|   protein kinase, lysine deficient 3 [Homo sapiens]
 gi|57210007|emb|CAI42732.1|   protein kinase, lysine deficient 3 [Homo sapiens]
 gi|57209549|emb|CAI40707.1|   protein kinase, lysine deficient 3 [Homo sapiens]
          Length = 1790

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%)

Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624
            + F  + E +L G +  +LV EL + G+L   L++ K    + L+      +  GL++LH
Sbjct: 207  VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265

Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682
            +    II+RDLK  N+  F   P  ++  KI D G+A        K+  GTP F APE+ 
Sbjct: 266  TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321

Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740
              +  Y++  DVY+FG+ + ++ T+         +    +  +I  K+   +K   +   
Sbjct: 322  EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773
              P V+++I+ C+++N  ER     + D+LN A
Sbjct: 374  TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403



>gi|40789046|dbj|BAA83053.2|   KIAA1101 protein [Homo sapiens]
          Length = 467

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 61/205 (29%), Positives = 98/205 (47%), Gaps = 30/205 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKAS-------LTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635
            LVM+L S GS+  +++   A        L  +    I   V +GL YLH    I+RD+K 
Sbjct: 30   LVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKA 89

Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688
             N+LL           +IAD+G++ +    G        KT  GTP + APEV      Y
Sbjct: 90   GNILL-----GEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGY 144

Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
            + +AD++SFG+   ++ T            V  L   N+   LE   +  + +K+YG   
Sbjct: 145  DFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYG--- 201

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766
                 K+I  CL+++P++RPT+A++
Sbjct: 202  -KSFRKMISLCLQKDPEKRPTAAEL 225



>gi|19908348|gb|AAL99253.1|   putative protein kinase WNK3 [Homo sapiens]
          Length = 1800

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 60/213 (28%), Positives = 106/213 (49%), Gaps = 20/213 (9%)

Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624
            + F  + E +L G +  +LV EL + G+L   L++ K    + L+      +  GL++LH
Sbjct: 207  VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCR-QILKGLQFLH 265

Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682
            +    II+RDLK  N+  F   P  ++  KI D G+A        K+  GTP F APE+ 
Sbjct: 266  TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLMRTSFAKSVIGTPEFMAPEMY 321

Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVK--EYGCA 1740
              +  Y++  DVY+FG+ + ++ T+         +    +  +I  K+   +K   +   
Sbjct: 322  EEH--YDESVDVYAFGMCMLEMATS------EYPYSECQNAAQIYRKVTSGIKPASFNKV 373

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773
              P V+++I+ C+++N  ER     + D+LN A
Sbjct: 374  TDPEVKEIIEGCIRQNKSER---LSIRDLLNHA 403



>gi|496091|gb|AAA60247.1|   RAF1
          Length = 421

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 56/172 (32%), Positives = 92/172 (53%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RD+K +N+ L     +  +  KI D+G+A    R      +
Sbjct: 221  IARQTAQGMDYLHAKNIIHRDMKSNNIFL-----HEGLTVKIGDFGLATVKSRWSGSQQV 275

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R   N  ++ Q+DVYS+G++LY+++ TG      +   ++   + 
Sbjct: 276  EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELI-TGELPYSHINNRDQIIFMV 334

Query: 1726 IQG-KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G   PD  K Y   P  M ++L+  C+K+  +ERP   Q   IL+S EL+
Sbjct: 335  GRGYASPDLSKLYKNCPKAM-KRLVADCVKKVKEERPLFPQ---ILSSIELL 382



>gi|227082|prf||1613537A   c-raf1 protooncogene
          Length = 386

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 56/172 (32%), Positives = 92/172 (53%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RD+K +N+ L     +  +  KI D+G+A    R      +
Sbjct: 186  IARQTAQGMDYLHAKNIIHRDMKSNNIFL-----HEGLTVKIGDFGLATVKSRWSGSQQV 240

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R   N  ++ Q+DVYS+G++LY+++ TG      +   ++   + 
Sbjct: 241  EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELM-TGELPYSHINNRDQIIFMV 299

Query: 1726 IQG-KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G   PD  K Y   P  M ++L+  C+K+  +ERP   Q   IL+S EL+
Sbjct: 300  GRGYASPDLSKLYKNCPKAM-KRLVADCVKKVKEERPLFPQ---ILSSIELL 347



>gi|55961054|emb|CAI13543.1|   mitogen-activated protein kinase-activated protein kinase 2 [Homo
            sapiens]
 gi|10863901|ref|NP_004750.1|   mitogen-activated protein kinase-activated protein kinase 2 isoform 1
            [Homo sapiens]
 gi|627537|pir||JC2204   MAPK-activated protein kinase (EC 2.7.1.-) 2 - human
 gi|530090|gb|AAA20851.1|   MAP kinase activated protein kinase 2
          Length = 370

 Score = 68.9 bits (167), Expect = 1e-10
 Identities = 60/201 (29%), Positives = 92/201 (45%), Gaps = 20/201 (9%)

Query: 1572 EFLLAGIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIY 1630
            E L AG +  ++VME    G L  R+  +   + T      I   + + ++YLHS  I +
Sbjct: 125  ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIA-QYCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RD+KP N+L  +  PNA  I K+ D+G A +      + T   TP + APEV  G   Y+
Sbjct: 185  RDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYD 241

Query: 1690 QQADVYSFGLLLYDIL--------TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
            +  D++S G+++Y +L          G  I  G+K      + E        V E     
Sbjct: 242  KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE----- 296

Query: 1742 WPMVEKLIKQCLKENPQERPT 1762
               V+ LI+  LK  P +R T
Sbjct: 297  --EVKMLIRNLLKTEPTQRMT 315



>gi|4502557|ref|NP_001735.1|   calcium/calmodulin-dependent protein kinase IV [Homo sapiens]
 gi|19343925|gb|AAH25687.1|   Calcium/calmodulin-dependent protein kinase IV [Homo sapiens]
 gi|871845|dbj|BAA06403.1|   calmodulin-dependent protein kinase IV [Homo sapiens]
 gi|539546|pir||A53036   Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.123) IV - human
 gi|2499586|sp|Q16566|KCC4_HUMAN   Calcium/calmodulin-dependent protein kinase type IV (CAM kinase-GR)
            (CaMK IV)
 gi|306479|gb|AAA35639.1|   calcium/calmodulin-dependent protein kinase
 gi|407006|gb|AAA18251.1|   calcium/calmodulin dependent protein kinase
          Length = 473

 Score = 68.9 bits (167), Expect = 1e-10
 Identities = 45/125 (36%), Positives = 74/125 (59%), Gaps = 7/125 (5%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LV+EL + G L DR++++   S            + + + YLH   I++RDLKP N+L  
Sbjct: 116  LVLELVTGGELFDRIVEKGYYSERDAAD--AVKQILEAVAYLHENGIVHRDLKPENLLYA 173

Query: 1642 TLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700
            T  P+A +  KIAD+G+++    ++ +KT  GTPG+ APE+ RG   Y  + D++S G++
Sbjct: 174  TPAPDAPL--KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRG-CAYGPEVDMWSVGII 230

Query: 1701 LYDIL 1705
             Y +L
Sbjct: 231  TYILL 235



>gi|32481209|ref|NP_116584.2|   mitogen-activated protein kinase-activated protein kinase 2 isoform 2
            [Homo sapiens]
 gi|55961055|emb|CAI13544.1|   mitogen-activated protein kinase-activated protein kinase 2 [Homo
            sapiens]
 gi|37590438|gb|AAH36060.2|   Mitogen-activated protein kinase-activated protein kinase 2, isoform
            2 [Homo sapiens]
 gi|30851683|gb|AAH52584.1|   Mitogen-activated protein kinase-activated protein kinase 2, isoform
            2 [Homo sapiens]
 gi|1346538|sp|P49137|MAPK2_HUMAN   MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase
            2) (MAPKAP kinase 2) (MAPKAPK-2)
 gi|38492558|pdb|1NY3|A   Chain A, Crystal Structure Of Adp Bound To Map Kap Kinase 2
 gi|24158795|pdb|1KWP|B   Chain B, Crystal Structure Of Mapkap2
 gi|24158794|pdb|1KWP|A   Chain A, Crystal Structure Of Mapkap2
          Length = 400

 Score = 68.9 bits (167), Expect = 1e-10
 Identities = 60/201 (29%), Positives = 92/201 (45%), Gaps = 20/201 (9%)

Query: 1572 EFLLAGIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIY 1630
            E L AG +  ++VME    G L  R+  +   + T      I   + + ++YLHS  I +
Sbjct: 125  ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIA-QYCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RD+KP N+L  +  PNA  I K+ D+G A +      + T   TP + APEV  G   Y+
Sbjct: 185  RDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYD 241

Query: 1690 QQADVYSFGLLLYDIL--------TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
            +  D++S G+++Y +L          G  I  G+K      + E        V E     
Sbjct: 242  KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE----- 296

Query: 1742 WPMVEKLIKQCLKENPQERPT 1762
               V+ LI+  LK  P +R T
Sbjct: 297  --EVKMLIRNLLKTEPTQRMT 315



>gi|54035072|gb|AAH16695.2|   CAMK4 protein [Homo sapiens]
          Length = 503

 Score = 68.9 bits (167), Expect = 1e-10
 Identities = 45/125 (36%), Positives = 74/125 (59%), Gaps = 7/125 (5%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LV+EL + G L DR++++   S            + + + YLH   I++RDLKP N+L  
Sbjct: 146  LVLELVTGGELFDRIVEKGYYSERDAAD--AVKQILEAVAYLHENGIVHRDLKPENLLYA 203

Query: 1642 TLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700
            T  P+A +  KIAD+G+++    ++ +KT  GTPG+ APE+ RG   Y  + D++S G++
Sbjct: 204  TPAPDAPL--KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRG-CAYGPEVDMWSVGII 260

Query: 1701 LYDIL 1705
             Y +L
Sbjct: 261  TYILL 265



>gi|4758284|ref|NP_004432.1|   ephrin receptor EphB1 precursor [Homo sapiens]
 gi|1706663|sp|P54762|EPHB1_HUMAN   Ephrin type-B receptor 1 precursor (Tyrosine-protein kinase receptor
            EPH-2) (NET) (HEK6) (ELK)
 gi|1100112|gb|AAB08520.1|   protein tyrosine kinase [Homo sapiens]
          Length = 984

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 60/266 (22%), Positives = 121/266 (45%), Gaps = 32/266 (12%)

Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            RP M++ E    G+LD  L+Q+    T      +   +A G++YL     ++RDL   N+
Sbjct: 691  RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 750

Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688
            L+     N+ ++ K++D+G+++Y   +   TS+ T            + APE       +
Sbjct: 751  LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK-F 801

Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748
               +DV+S+G++++++++ G R    +   +  + +E   +LP P+    C     + +L
Sbjct: 802  TSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPM---DCP--AALHQL 856

Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803
            +  C +++   RP  A++ + L     N A L  +     +P   +++  +         
Sbjct: 857  MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 916

Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829
              WL      + + SFL   T G+TS
Sbjct: 917  DDWLSAIKMVQYRDSFL---TAGFTS 939



>gi|19263755|gb|AAH25307.1|   PRKD2 protein [Homo sapiens]
          Length = 538

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME      L+ +L  +K  L   L   +   +   LR+LH   I++ DLKP NVLL +
Sbjct: 285  VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 344

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              P   +  K+ D+G A+       + S  GTP + APEV   N  YN+  D++S G+++
Sbjct: 345  ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 401

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            Y  L+          FP   DE +I  ++ +    Y  +PW  +                
Sbjct: 402  YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 436

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788
             SA   D++N+   V + +R  + K++
Sbjct: 437  -SAGAIDLINNLLQVKMRKRYSVDKSL 462



>gi|22760266|dbj|BAC11127.1|   unnamed protein product [Homo sapiens]
          Length = 721

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME      L+ +L  +K  L   L   +   +   LR+LH   I++ DLKP NVLL +
Sbjct: 468  VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 527

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              P   +  K+ D+G A+       + S  GTP + APEV   N  YN+  D++S G+++
Sbjct: 528  ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 584

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            Y  L+          FP   DE +I  ++ +    Y  +PW  +                
Sbjct: 585  YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 619

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788
             SA   D++N+   V + +R  + K++
Sbjct: 620  -SAGAIDLINNLLQVKMRKRYSVDKSL 645



>gi|22761242|dbj|BAC11508.1|   unnamed protein product [Homo sapiens]
          Length = 721

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME      L+ +L  +K  L   L   +   +   LR+LH   I++ DLKP NVLL +
Sbjct: 468  VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 527

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              P   +  K+ D+G A+       + S  GTP + APEV   N  YN+  D++S G+++
Sbjct: 528  ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 584

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            Y  L+          FP   DE +I  ++ +    Y  +PW  +                
Sbjct: 585  YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 619

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788
             SA   D++N+   V + +R  + K++
Sbjct: 620  -SAGAIDLINNLLQVKMRKRYSVDKSL 645



>gi|7019543|ref|NP_037365.1|   serine threonine kinase 39 (STE20/SPS1 homolog, yeast) [Homo sapiens]
 gi|3851171|gb|AAC72238.1|   Ste-20 related kinase SPAK [Homo sapiens]
 gi|12643880|sp|Q9UEW8|STK39_HUMAN   STE20/SPS1-related proline-alanine rich protein kinase (Ste-20
            related kinase) (Serine/threonine-protein kinase 39)
            (DCHT)
          Length = 547

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 30/205 (14%)

Query: 1583 LVMELASKGSLDRLL-------QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635
            LVM+L S GS+  ++       +     L   +   I   V +GL YLH    I+RDLK 
Sbjct: 138  LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKA 197

Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688
             N+LL           +IAD+G++ +    G        KT  GTP + APEV      Y
Sbjct: 198  GNILL-----GEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGY 252

Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
            + +AD++SFG+   ++ T            V  L   N+   LE   +  + +K+YG   
Sbjct: 253  DFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYG--- 309

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766
                 KL+  CL+++P +RPT+A++
Sbjct: 310  -KSFRKLLSLCLQKDPSKRPTAAEL 333



>gi|19923468|ref|NP_057541.2|   protein kinase D2 [Homo sapiens]
 gi|12659007|gb|AAK01149.1|   protein kinase D2 [Homo sapiens]
 gi|20138711|sp|Q9BZL6|KPCD2_HUMAN   Protein kinase C, D2 type (nPKC-D2) (Protein kinase D2) (HSPC187)
          Length = 878

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME      L+ +L  +K  L   L   +   +   LR+LH   I++ DLKP NVLL +
Sbjct: 625  VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 684

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              P   +  K+ D+G A+       + S  GTP + APEV   N  YN+  D++S G+++
Sbjct: 685  ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 741

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            Y  L+          FP   DE +I  ++ +    Y  +PW  +                
Sbjct: 742  YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 776

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788
             SA   D++N+   V + +R  + K++
Sbjct: 777  -SAGAIDLINNLLQVKMRKRYSVDKSL 802



>gi|17736731|emb|CAC84640.1|   mixed lineage kinase 4beta [Homo sapiens]
 gi|24308330|ref|NP_115811.1|   mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 62/218 (28%), Positives = 108/218 (49%), Gaps = 29/218 (13%)

Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627
            LV+E A  G+L+R L    A+            R   H +   A+ +A G+ YLH     
Sbjct: 198  LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257

Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683
             I++RDLK  N+LL     +  I     KI D+G+A+   R    ++ GT  + APEV +
Sbjct: 258  PILHRDLKSSNILLLEEIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317

Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
             + ++++ +D++S G+LL+++LT     R ++GL         ++   +P         P
Sbjct: 318  SS-LFSKGSDIWSCGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
             P   KL+K+C +++P  RP+ A + + L + E   +T
Sbjct: 371  EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407



>gi|17736729|emb|CAC84639.1|   mixed lineage kinase 4alpha [Homo sapiens]
          Length = 570

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 62/218 (28%), Positives = 108/218 (49%), Gaps = 29/218 (13%)

Query: 1583 LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGLRYLHSAM-- 1627
            LV+E A  G+L+R L    A+            R   H +   A+ +A G+ YLH     
Sbjct: 198  LVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFV 257

Query: 1628 -IIYRDLKPHNVLLFTLYPNAAII---AKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 1683
             I++RDLK  N+LL     +  I     KI D+G+A+   R    ++ GT  + APEV +
Sbjct: 258  PILHRDLKSSNILLLEEIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIK 317

Query: 1684 GNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
             + ++++ +D++S G+LL+++LT     R ++GL         ++   +P         P
Sbjct: 318  SS-LFSKGSDIWSCGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST------CP 370

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
             P   KL+K+C +++P  RP+ A + + L + E   +T
Sbjct: 371  EPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407



>gi|27769064|gb|AAH42334.1|   Similar to RIKEN cDNA 1300018K11 gene [Homo sapiens]
          Length = 560

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 93/344 (27%), Positives = 154/344 (44%), Gaps = 35/344 (10%)

Query: 673  EGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKK---SNS 729
            E  A GS+ N ++ V        F PD+       + +DL+  GS  SFL       SN 
Sbjct: 80   ETRAFGSNPNLTKVVFLNTQLCQFRPDAF--GGLPRLEDLEVTGS--SFLNLSTNIFSNL 135

Query: 730  ISVGEFYRDA-VLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK-MSCIANLD 787
             S+G+   +  +L+     L +H     L +L  L L  N+  + P  L + ++ +  L+
Sbjct: 136  TSLGKLTLNFNMLEALPEGLFQH-----LAALESLHLQGNRLQALPRRLFQPLTHLKTLN 190

Query: 788  VSRNDIG--PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGI 845
            +++N +   P  +  P     TLK   LS N LS +P+ +   +  L++L L+ N IS +
Sbjct: 191  LAQNLLAQLPEELFHPLTSLQTLK---LSNNALSGLPQGVFGKLGSLQELFLDSNNISEL 247

Query: 846  CSPL--RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPF----LPPSMT 899
               +  +L  L+ L L +N I+ L  +   +   +   S + N L  +P       P + 
Sbjct: 248  PPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLV 307

Query: 900  ILKLSQNKFSCIPEAIL-NLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL 958
             L L+ N+   + E    +L +LRSL +S N I +LP         L +L    N ++ L
Sbjct: 308  GLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTAL 367

Query: 959  DLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002
              +    L S++E L LS N+L  +P  I         D +YNL
Sbjct: 368  HPALFQNL-SKLELLSLSKNQLTTLPEGI--------FDTNYNL 402



>gi|4884154|emb|CAB43292.1|   hypothetical protein [Homo sapiens]
 gi|7434268|pir||T08777   probable protein kinase C (EC 2.7.1.-) mu - human (fragment)
          Length = 542

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 30/207 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME      L+ +L  +K  L   L   +   +   LR+LH   I++ DLKP NVLL +
Sbjct: 289  VVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 348

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              P   +  K+ D+G A+       + S  GTP + APEV   N  YN+  D++S G+++
Sbjct: 349  ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIM 405

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            Y  L+          FP   DE +I  ++ +    Y  +PW  +                
Sbjct: 406  YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI---------------- 440

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788
             SA   D++N+   V + +R  + K++
Sbjct: 441  -SAGAIDLINNLLQVKMRKRYSVDKSL 466



>gi|49457444|emb|CAG47021.1|   STK17B [Homo sapiens]
          Length = 372

 Score = 68.6 bits (166), Expect = 1e-10
 Identities = 52/186 (27%), Positives = 93/186 (50%), Gaps = 12/186 (6%)

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLL 1640
            +L++E A+ G +  L   + A +       R+   + +G+ YLH   I++ DLKP N+LL
Sbjct: 107  ILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILL 166

Query: 1641 FTLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697
             ++YP   I  KI D+G+++   + C   ++   GTP + APE+   + I     D+++ 
Sbjct: 167  SSIYPLGDI--KIVDFGMSRKIGHACE--LREIMGTPEYLAPEILNYDPI-TTATDMWNI 221

Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757
            G++ Y +LT     V      N+   L I     D  +E   +   +    I+  L +NP
Sbjct: 222  GIIAYMLLTHTSPFVGE---DNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNP 278

Query: 1758 QERPTS 1763
            ++RPT+
Sbjct: 279  EKRPTA 284



>gi|2144413|pir||TVHUBF   protein kinase B-raf (EC 2.7.1.-) - human
          Length = 765

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RDLK +N+ L     +  +  KI D+G+A    R       
Sbjct: 555  IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 609

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R      Y+ Q+DVY+FG++LY+++ TG      +   ++   + 
Sbjct: 610  EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 668

Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G L PD  K     P  M ++L+ +CLK+   ERP   Q   IL S EL+
Sbjct: 669  GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 716



>gi|12314068|emb|CAC12717.1|   GD:STK6 [Homo sapiens]
 gi|38327570|ref|NP_940838.1|   serine/threonine protein kinase 6 [Homo sapiens]
 gi|38327568|ref|NP_940837.1|   serine/threonine protein kinase 6 [Homo sapiens]
 gi|38327566|ref|NP_940836.1|   serine/threonine protein kinase 6 [Homo sapiens]
 gi|38327564|ref|NP_940835.1|   serine/threonine protein kinase 6 [Homo sapiens]
 gi|38327562|ref|NP_003591.2|   serine/threonine protein kinase 6 [Homo sapiens]
 gi|38327572|ref|NP_940839.1|   serine/threonine protein kinase 6 [Homo sapiens]
 gi|2979628|gb|AAC12708.1|   aurora-related kinase 1 [Homo sapiens]
          Length = 403

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 208  LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIAD+G + +       T  GT  +  PE+  G  +++++ D++S G+
Sbjct: 264  L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 318  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 370  QRPMLREVLE 379



>gi|4502553|ref|NP_003647.1|   calcium/calmodulin-dependent protein kinase I [Homo sapiens]
 gi|1362763|pir||S57347   Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.123) I - human
 gi|3122301|sp|Q14012|KCC1A_HUMAN   Calcium/calmodulin-dependent protein kinase type 1 (CaM kinase I)
            (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)
 gi|790790|gb|AAA99458.1|   cam kinase I
          Length = 370

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 56/191 (29%), Positives = 101/191 (52%), Gaps = 22/191 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            L+M+L S G L DR+++  K   T     R+   V D ++YLH   I++RDLKP N+L +
Sbjct: 93   LIMQLVSGGELFDRIVE--KGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYY 150

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGI-KTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700
            +L  ++ I+  I+D+G+++      +  T+ GTPG+ APEV      Y++  D +S G++
Sbjct: 151  SLDEDSKIM--ISDFGLSKMEDPGSVLSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVI 207

Query: 1701 LYDILTTGGRIVEGLKFPNEFDE--LEIQGKLPDPVKEYGCAPWPMV----EKLIKQCLK 1754
             Y IL  G        +P  +DE   ++  ++     E+    W  +    +  I+  ++
Sbjct: 208  AY-ILLCG--------YPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLME 258

Query: 1755 ENPQERPTSAQ 1765
            ++P++R T  Q
Sbjct: 259  KDPEKRFTCEQ 269



>gi|51094777|gb|EAL24023.1|   v-raf murine sarcoma viral oncogene homolog B1 [Homo sapiens]
 gi|33188459|ref|NP_004324.2|   v-raf murine sarcoma viral oncogene homolog B1 [Homo sapiens]
 gi|50403720|sp|P15056|BRAF1_HUMAN   B-Raf proto-oncogene serine/threonine-protein kinase (p94) (v-Raf
            murine sarcoma viral oncogene homolog B1)
 gi|41387220|gb|AAA35609.2|   B-raf protein [Homo sapiens]
          Length = 766

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RDLK +N+ L     +  +  KI D+G+A    R       
Sbjct: 556  IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 610

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R      Y+ Q+DVY+FG++LY+++ TG      +   ++   + 
Sbjct: 611  EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 669

Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G L PD  K     P  M ++L+ +CLK+   ERP   Q   IL S EL+
Sbjct: 670  GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 717



>gi|56792342|gb|AAW30454.1|   AKAP9-BRAF fusion protein [Homo sapiens]
          Length = 1492

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RDLK +N+ L     +  +  KI D+G+A    R       
Sbjct: 1282 IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 1336

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R      Y+ Q+DVY+FG++LY+++ TG      +   ++   + 
Sbjct: 1337 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 1395

Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G L PD  K     P  M ++L+ +CLK+   ERP   Q   IL S EL+
Sbjct: 1396 GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 1443



>gi|12803361|gb|AAH02499.1|   STK6 protein [Homo sapiens]
 gi|20073237|gb|AAH27464.1|   Serine/threonine protein kinase 6 [Homo sapiens]
 gi|13623611|gb|AAH06423.1|   Serine/threonine protein kinase 6 [Homo sapiens]
 gi|12654873|gb|AAH01280.1|   Serine/threonine protein kinase 6 [Homo sapiens]
 gi|27923855|sp|O14965|STK6_HUMAN   Serine/threonine-protein kinase 6 (Serine/threonine kinase 15)
            (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1)
            (hARK1) (Aurora-A) (Breast-tumor-amplified kinase)
          Length = 403

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 208  LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIAD+G + +       T  GT  +  PE+  G  +++++ D++S G+
Sbjct: 264  L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 318  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 370  QRPMLREVLE 379



>gi|19424132|ref|NP_598001.1|   NIMA (never in mitosis gene a)-related kinase 7 [Homo sapiens]
 gi|37537965|sp|Q8TDX7|NEK7_HUMAN   Serine/threonine-protein kinase Nek7 (NimA-related protein kinase 7)
 gi|19032281|dbj|BAB85632.1|   NEK7 [Homo sapiens]
          Length = 302

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 50/201 (24%), Positives = 97/201 (48%), Gaps = 32/201 (15%)

Query: 1583 LVMELASKGSLDRLLQ---QDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVL 1639
            +V+ELA  G L R+++   + K  +      +  + +   L ++HS  +++RD+KP NV 
Sbjct: 109  IVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVF 168

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSE-----GTPGFRAPEVARGNVIYNQQADV 1694
            +      A  + K+ D G+ ++      KT+      GTP + +PE    N  YN ++D+
Sbjct: 169  I-----TATGVVKLGDLGLGRF---FSSKTTAAHSLVGTPYYMSPERIHENG-YNFKSDI 219

Query: 1695 YSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPM------VEKL 1748
            +S G LLY+        +  L+ P   D++ +   L   +++    P P       + +L
Sbjct: 220  WSLGCLLYE--------MAALQSPFYGDKMNLY-SLCKKIEQCDYPPLPSDHYSEELRQL 270

Query: 1749 IKQCLKENPQERPTSAQVFDI 1769
            +  C+  +P++RP    V+D+
Sbjct: 271  VNMCINPDPEKRPDVTYVYDV 291



>gi|11125348|emb|CAC15059.1|   putative protein kinase [Homo sapiens]
 gi|12711660|ref|NP_061852.1|   WNK lysine deficient protein kinase 1 [Homo sapiens]
 gi|41688795|sp|Q9H4A3|WNK1_HUMAN   Serine/threonine-protein kinase WNK1 (Protein kinase with no lysine
            1) (Protein kinase, lysine-deficient 1) (Kinase deficient
            protein)
          Length = 2382

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 63/224 (28%), Positives = 106/224 (47%), Gaps = 42/224 (18%)

Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624
            + F  + E  + G +  +LV EL + G+L   L++ K    + L+      +  GL++LH
Sbjct: 281  VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCR-QILKGLQFLH 339

Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682
            +    II+RDLK  N+  F   P  ++  KI D G+A        K+  GTP F APE+ 
Sbjct: 340  TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMY 395

Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTG-------------GRIVEGLKFPNEFDELEIQGK 1729
                 Y++  DVY+FG+ + ++ T+               R+  G+K P  FD++ I   
Sbjct: 396  EEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK-PASFDKVAI--- 449

Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773
                         P V+++I+ C+++N  ER     + D+LN A
Sbjct: 450  -------------PEVKEIIEGCIRQNKDER---YSIKDLLNHA 477



>gi|6933864|gb|AAF31483.1|   kinase deficient protein KDP [Homo sapiens]
          Length = 670

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 63/224 (28%), Positives = 106/224 (47%), Gaps = 42/224 (18%)

Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624
            + F  + E  + G +  +LV EL + G+L   L++ K    + L+      +  GL++LH
Sbjct: 281  VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCR-QILKGLQFLH 339

Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682
            +    II+RDLK  N+  F   P  ++  KI D G+A        K+  GTP F APE+ 
Sbjct: 340  TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMY 395

Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTG-------------GRIVEGLKFPNEFDELEIQGK 1729
                 Y++  DVY+FG+ + ++ T+               R+  G+K P  FD++ I   
Sbjct: 396  EEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK-PASFDKVAI--- 449

Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773
                         P V+++I+ C+++N  ER     + D+LN A
Sbjct: 450  -------------PEVKEIIEGCIRQNKDER---YSIKDLLNHA 477



>gi|6851302|gb|AAF29508.1|   STK15 serine/threonine kinase [Homo sapiens]
 gi|3213197|gb|AAC63902.1|   serine/threonine kinase [Homo sapiens]
          Length = 403

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 208  LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIAD+G + +       T  GT  +  PE+  G  +++++ D++S G+
Sbjct: 264  L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 318  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 370  QRPMLREVLE 379



>gi|5441948|gb|AAD43193.1|   serine/threonine protein kinase; similar to B-raf proto-oncogene;
            multiple spliced forms; exon 7 is unusually highly
            conserved at the nucleotide level; similar to Q04982
            (PID:g464647) [Homo sapiens]
          Length = 651

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RDLK +N+ L     +  +  KI D+G+A    R       
Sbjct: 441  IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 495

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R      Y+ Q+DVY+FG++LY+++ TG      +   ++   + 
Sbjct: 496  EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 554

Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G L PD  K     P  M ++L+ +CLK+   ERP   Q   IL S EL+
Sbjct: 555  GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 602



>gi|4103971|gb|AAD01901.1|   Ste20-like protein kinase [Homo sapiens]
          Length = 547

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 30/205 (14%)

Query: 1583 LVMELASKGSLDRLL-------QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635
            LVM+L S GS+  ++       +     L   +   I   V +GL YLH    I+RDLK 
Sbjct: 138  LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIFKEVLEGLDYLHRNGQIHRDLKA 197

Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI-------KTSEGTPGFRAPEVARGNVIY 1688
             N+LL           +IAD+G++ +    G        KT  GTP + APEV      Y
Sbjct: 198  GNILL-----GEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGY 252

Query: 1689 NQQADVYSFGLLLYDILTTGGRI-------VEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
            + +AD++SFG+   ++ T            V  L   N+   LE   +  + +K+YG   
Sbjct: 253  DFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYG--- 309

Query: 1742 WPMVEKLIKQCLKENPQERPTSAQV 1766
                 KL+  CL+++P +RPT+A++
Sbjct: 310  -KSFRKLLSLCLQKDPSKRPTAAEL 333



>gi|7446411|pir||JC5974   aurora-related kinase 1 (EC 2.7.-.-) - human
          Length = 403

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 208  LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 263

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIAD+G + +       T  GT  +  PE+  G  +++++ D++S G+
Sbjct: 264  L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 317

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 318  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 369

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 370  QRPMLREVLE 379



>gi|47169341|pdb|1UWH|B   Chain B, The Complex Of Wild Type B-Raf And Bay439006
 gi|47169340|pdb|1UWH|A   Chain A, The Complex Of Wild Type B-Raf And Bay439006
          Length = 276

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RDLK +N+ L     +  +  KI D+G+A    R       
Sbjct: 109  IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 163

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R      Y+ Q+DVY+FG++LY+++ TG      +   ++   + 
Sbjct: 164  EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 222

Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G L PD  K     P  M ++L+ +CLK+   ERP   Q   IL S EL+
Sbjct: 223  GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 270



>gi|37926805|pdb|1MQ4|A   Chain A, Crystal Structure Of Aurora-A Protein Kinase
          Length = 272

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 89   LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 144

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIAD+G + +       T  GT  +  PE+  G  +++++ D++S G+
Sbjct: 145  L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 198

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 199  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 250

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 251  QRPMLREVLE 260



>gi|30749504|pdb|1MUO|A   Chain A, Crystal Structure Of Aurora-2, An Oncogenic Serine-
            Threonine Kinase
          Length = 297

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 56/190 (29%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 102  LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 157

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIAD+G + +       T  GT  +  PE+  G  +++++ D++S G+
Sbjct: 158  L-----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 211

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 212  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 263

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 264  QRPMLREVLE 273



>gi|179535|gb|AAA96495.1|   B-raf protein
          Length = 328

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RDLK +N+ L     +  +  KI D+G+A    R       
Sbjct: 118  IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATVKSRWSGSHQF 172

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R      Y+ Q+DVY+FG++LY+++ TG      +   ++   + 
Sbjct: 173  EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 231

Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G L PD  K     P  M ++L+ +CLK+   ERP   Q   IL S EL+
Sbjct: 232  GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 279



>gi|20521007|dbj|BAA20802.2|   KIAA0344 [Homo sapiens]
          Length = 2066

 Score = 68.2 bits (165), Expect = 2e-10
 Identities = 63/224 (28%), Positives = 106/224 (47%), Gaps = 42/224 (18%)

Query: 1565 LEFEQAPEFLLAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1624
            + F  + E  + G +  +LV EL + G+L   L++ K    + L+      +  GL++LH
Sbjct: 213  VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCR-QILKGLQFLH 271

Query: 1625 SAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 1682
            +    II+RDLK  N+  F   P  ++  KI D G+A        K+  GTP F APE+ 
Sbjct: 272  TRTPPIIHRDLKCDNI--FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMY 327

Query: 1683 RGNVIYNQQADVYSFGLLLYDILTTG-------------GRIVEGLKFPNEFDELEIQGK 1729
                 Y++  DVY+FG+ + ++ T+               R+  G+K P  FD++ I   
Sbjct: 328  EEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK-PASFDKVAI--- 381

Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSA 1773
                         P V+++I+ C+++N  ER     + D+LN A
Sbjct: 382  -------------PEVKEIIEGCIRQNKDER---YSIKDLLNHA 409



>gi|14602490|gb|AAH09751.1|   Aurora kinase B [Homo sapiens]
          Length = 344

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 18/186 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            L++E A +G L + LQ+   +        I   +AD L Y H   +I+RD+KP N+LL  
Sbjct: 152  LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 208

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                     KIAD+G + +   +  KT  GT  +  PE+  G  ++N++ D++  G+L Y
Sbjct: 209  ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 264

Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPM-VEKLIKQCLKENPQER 1760
            ++L  G    E       +  + ++  K P  V        PM  + LI + L+ NP ER
Sbjct: 265  ELL-VGNPPFESASHNETYRRIVKVDLKFPASV--------PMGAQDLISKLLRHNPSER 315

Query: 1761 PTSAQV 1766
               AQV
Sbjct: 316  LPLAQV 321



>gi|56202636|emb|CAI19991.1|   calcium/calmodulin-dependent protein kinase IG [Homo sapiens]
 gi|21619665|gb|AAH32787.1|   Calcium/calmodulin-dependent protein kinase IG [Homo sapiens]
 gi|14196445|ref|NP_065172.1|   calcium/calmodulin-dependent protein kinase IG [Homo sapiens]
          Length = 476

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVM+L S G L DR+L+  +   T      +   V   ++YLH   I++RDLKP N+L  
Sbjct: 95   LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
            T   N+ I+  I D+G+++      + T+ GTPG+ APEV      Y++  D +S G++ 
Sbjct: 153  TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209

Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755
            Y IL  G        +P  ++E E  +  K+ +   E+    W  + +  K      L++
Sbjct: 210  Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260

Query: 1756 NPQERPT 1762
            +P ER T
Sbjct: 261  DPNERYT 267



>gi|1161364|gb|AAB60412.1|   tyrosine kinase
          Length = 527

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 51/192 (26%), Positives = 95/192 (49%), Gaps = 16/192 (8%)

Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            +P  +V E    G L   L+++K  L + +   +   + +G+ YL     I+RDL   N 
Sbjct: 337  KPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQXICEGMEYLERNGYIHRDLAARNC 396

Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTP---GFRAPEVARGNVIYNQQADVY 1695
            L+     ++  I KI+D+G+ +Y       +S G      +  PEV   N  Y+ ++DV+
Sbjct: 397  LV-----SSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK-YSSKSDVW 450

Query: 1696 SFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPM-VEKLIKQCLK 1754
            SFG+L++++ T G      + F N+   L++   + +  + Y     PM + +++  C  
Sbjct: 451  SFGVLMWEVFTEG-----KMPFENK-SNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504

Query: 1755 ENPQERPTSAQV 1766
            E P+ RPT A++
Sbjct: 505  EKPEGRPTFAEL 516



>gi|37727961|gb|AAR02359.1|   interleukin-1 receptor-associated kinase 4 variant [Homo sapiens]
 gi|37727959|gb|AAR02358.1|   interleukin-1 receptor-associated kinase 4 [Homo sapiens]
 gi|7020684|dbj|BAA91232.1|   unnamed protein product [Homo sapiens]
 gi|60502299|gb|AAX22228.1|   interleukin-1 receptor associated kinase-4 [Homo sapiens]
 gi|15426432|gb|AAH13316.1|   Interleukin-1 receptor-associated kinase 4 [Homo sapiens]
 gi|26000793|gb|AAN75440.1|   interleukin-1 receptor-associated kinase 4 [Homo sapiens]
 gi|50401181|sp|Q9NWZ3|IRAK4_HUMAN   Interleukin-1 receptor-associated kinase-4 (IRAK-4) (NY-REN-64
            antigen)
          Length = 460

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 55/191 (28%), Positives = 95/191 (49%), Gaps = 20/191 (10%)

Query: 1593 LDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIA 1651
            LDRL   D    L+  ++ +IA   A+G+ +LH    I+RD+K  N+LL     + A  A
Sbjct: 271  LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL-----DEAFTA 325

Query: 1652 KIADYGIAQYCCRMG--IKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT- 1706
            KI+D+G+A+   +    + TS   GT  + APE  RG +    ++D+YSFG++L +I+T 
Sbjct: 326  KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 383

Query: 1707 -------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759
                      +++  +K   E +E  I+  +   + +        +  +  QCL E   +
Sbjct: 384  LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNK 443

Query: 1760 RPTSAQVFDIL 1770
            RP   +V  +L
Sbjct: 444  RPDIKKVQQLL 454



>gi|1848077|emb|CAA26485.1|   c-src [Homo sapiens]
          Length = 351

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  +V E  SKGSL   L+ +     R  Q   +A  +A G+ Y+     ++RDL+  N+
Sbjct: 151  PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 210

Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690
            L+        ++ K+AD+G+A      +Y  R G K       + APE A    +Y +  
Sbjct: 211  LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 258

Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LL ++ T G     G+      D++E   ++P P +   C     +  L+
Sbjct: 259  IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 313

Query: 1750 KQCLKENPQERPT 1762
             QC ++ P+ERPT
Sbjct: 314  CQCWRKEPEERPT 326



>gi|4758194|ref|NP_004217.1|   serine/threonine kinase 17b (apoptosis-inducing) [Homo sapiens]
 gi|16359143|gb|AAH16040.1|   Serine/threonine kinase 17b (apoptosis-inducing) [Homo sapiens]
 gi|14423909|sp|O94768|ST17B_HUMAN   Serine/threonine-protein kinase 17B (DAP kinase-related
            apoptosis-inducing protein kinase 2)
 gi|3834356|dbj|BAA34127.1|   DRAK2 [Homo sapiens]
          Length = 372

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 52/186 (27%), Positives = 93/186 (50%), Gaps = 12/186 (6%)

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLL 1640
            +L++E A+ G +  L   + A +       R+   + +G+ YLH   I++ DLKP N+LL
Sbjct: 107  ILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILL 166

Query: 1641 FTLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697
             ++YP   I  KI D+G+++   + C   ++   GTP + APE+   + I     D+++ 
Sbjct: 167  SSIYPLGDI--KIVDFGMSRKIGHACE--LREIMGTPEYLAPEILNYDPI-TTATDMWNI 221

Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757
            G++ Y +LT     V      N+   L I     D  +E   +   +    I+  L +NP
Sbjct: 222  GIIAYMLLTHTSPFVGE---DNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNP 278

Query: 1758 QERPTS 1763
            ++RPT+
Sbjct: 279  EKRPTA 284



>gi|15079460|gb|AAH11566.1|   SRC protein [Homo sapiens]
 gi|55930980|gb|AAH51270.2|   Proto-oncogene tyrosine-protein kinase SRC [Homo sapiens]
 gi|13374724|emb|CAC34523.1|   GD:SRC [Homo sapiens]
 gi|38202217|ref|NP_938033.1|   proto-oncogene tyrosine-protein kinase SRC [Homo sapiens]
 gi|4885609|ref|NP_005408.1|   proto-oncogene tyrosine-protein kinase SRC [Homo sapiens]
 gi|125711|sp|P12931|SRC_HUMAN   Proto-oncogene tyrosine-protein kinase Src (p60-Src) (c-Src)
 gi|338460|gb|AAA60584.1|   pp60 c-src-1 protein
          Length = 536

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  +V E  SKGSL   L+ +     R  Q   +A  +A G+ Y+     ++RDL+  N+
Sbjct: 336  PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 395

Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690
            L+        ++ K+AD+G+A      +Y  R G K       + APE A    +Y +  
Sbjct: 396  LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 443

Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LL ++ T G     G+      D++E   ++P P +   C     +  L+
Sbjct: 444  IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 498

Query: 1750 KQCLKENPQERPT 1762
             QC ++ P+ERPT
Sbjct: 499  CQCWRKEPEERPT 511



>gi|4557511|ref|NP_001339.1|   death-associated protein kinase 3 [Homo sapiens]
 gi|38604691|sp|O43293|DAPK3_HUMAN   Death-associated protein kinase 3 (DAP kinase 3) (DAP-like kinase)
            (Dlk) (ZIP-kinase)
 gi|2911156|dbj|BAA24955.1|   ZIP-kinase [Homo sapiens]
 gi|5162884|dbj|BAA81746.1|   ZIP kinase [Homo sapiens]
          Length = 454

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 58/186 (31%), Positives = 89/186 (47%), Gaps = 9/186 (4%)

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +L++EL S G L   L + K SLT     +    + DG+ YLHS  I + DLKP N++L 
Sbjct: 90   VLILELVSGGELFDFLAE-KESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL 148

Query: 1642 TL-YPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
                PN  I  K+ D+GIA         K   GTP F APE+     +   +AD++S G+
Sbjct: 149  DKNVPNPRI--KLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPL-GLEADMWSIGV 205

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759
            + Y +L+     +   K   +     I     D  +EY      + +  I++ L ++P+ 
Sbjct: 206  ITYILLSGASPFLGETK---QETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKR 262

Query: 1760 RPTSAQ 1765
            R T AQ
Sbjct: 263  RMTIAQ 268



>gi|33870194|gb|AAH13300.2|   AURKB protein [Homo sapiens]
          Length = 371

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 18/186 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            L++E A +G L + LQ+   +        I   +AD L Y H   +I+RD+KP N+LL  
Sbjct: 179  LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 235

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                     KIAD+G + +   +  KT  GT  +  PE+  G  ++N++ D++  G+L Y
Sbjct: 236  ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 291

Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPM-VEKLIKQCLKENPQER 1760
            ++L  G    E       +  + ++  K P  V        PM  + LI + L+ NP ER
Sbjct: 292  ELL-VGNPPFESASHNETYRRIVKVDLKFPASV--------PMGAQDLISKLLRHNPSER 342

Query: 1761 PTSAQV 1766
               AQV
Sbjct: 343  LPLAQV 348



>gi|20219010|gb|AAM15772.1|   interleukin-1 receptor associated kinase 4 [Homo sapiens]
          Length = 460

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 55/191 (28%), Positives = 95/191 (49%), Gaps = 20/191 (10%)

Query: 1593 LDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIA 1651
            LDRL   D    L+  ++ +IA   A+G+ +LH    I+RD+K  N+LL     + A  A
Sbjct: 271  LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL-----DEAFTA 325

Query: 1652 KIADYGIAQYCCRMG--IKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT- 1706
            KI+D+G+A+   +    + TS   GT  + APE  RG +    ++D+YSFG++L +I+T 
Sbjct: 326  KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 383

Query: 1707 -------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759
                      +++  +K   E +E  I+  +   + +        +  +  QCL E   +
Sbjct: 384  LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNK 443

Query: 1760 RPTSAQVFDIL 1770
            RP   +V  +L
Sbjct: 444  RPDIKKVQQLL 454



>gi|30271862|gb|AAP29964.1|   CLICK III [Homo sapiens]
          Length = 460

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVM+L S G L DR+L+  +   T      +   V   ++YLH   I++RDLKP N+L  
Sbjct: 95   LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
            T   N+ I+  I D+G+++      + T+ GTPG+ APEV      Y++  D +S G++ 
Sbjct: 153  TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209

Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755
            Y IL  G        +P  ++E E  +  K+ +   E+    W  + +  K      L++
Sbjct: 210  Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260

Query: 1756 NPQERPT 1762
            +P ER T
Sbjct: 261  DPNERYT 267



>gi|56205021|emb|CAI22921.1|   GD:SRC [Homo sapiens]
 gi|10436623|dbj|BAB14871.1|   unnamed protein product [Homo sapiens]
          Length = 251

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  +V E  SKGSL   L+ +     R  Q   +A  +A G+ Y+     ++RDL+  N+
Sbjct: 51   PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 110

Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690
            L+        ++ K+AD+G+A      +Y  R G K       + APE A    +Y +  
Sbjct: 111  LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 158

Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LL ++ T G     G+      D++E   ++P P +   C     +  L+
Sbjct: 159  IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 213

Query: 1750 KQCLKENPQERPT 1762
             QC ++ P+ERPT
Sbjct: 214  CQCWRKEPEERPT 226



>gi|10635153|emb|CAC10573.1|   GD:SRC [Homo sapiens]
 gi|625219|pir||TVHUSC   protein-tyrosine kinase (EC 2.7.1.112) src, neuronal - human
          Length = 542

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  +V E  SKGSL   L+ +     R  Q   +A  +A G+ Y+     ++RDL+  N+
Sbjct: 342  PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 401

Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690
            L+        ++ K+AD+G+A      +Y  R G K       + APE A    +Y +  
Sbjct: 402  LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 449

Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LL ++ T G     G+      D++E   ++P P +   C     +  L+
Sbjct: 450  IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 504

Query: 1750 KQCLKENPQERPT 1762
             QC ++ P+ERPT
Sbjct: 505  CQCWRKEPEERPT 517



>gi|7023013|dbj|BAA91801.1|   unnamed protein product [Homo sapiens]
          Length = 183

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 57/175 (32%), Positives = 89/175 (50%), Gaps = 8/175 (4%)

Query: 853  ELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPP---SMTILKLSQNKFS 909
            +L  L++S+N I  + E+ +  C  ++      N L  +P   P   ++T L ++     
Sbjct: 2    QLVELDVSRNEIPEIPES-ISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQ 60

Query: 910  CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSR 969
             +PE I NL +L SL++  N + YLP     +   L EL   +N+I  L  S  A L   
Sbjct: 61   SLPENIGNLYNLASLELRENLLTYLPDSLT-QLRRLEELDLGNNEIYNLPESIGALL--H 117

Query: 970  VEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDE 1024
            ++ L L  N+L E+P EIG L+NL  LDVS N  L   P E+  L+ + DL + +
Sbjct: 118  LKDLWLDGNQLSELPQEIGNLKNLLCLDVSEN-RLERLPEEISGLTSLTDLVISQ 171



 Score = 57.4 bits (137), Expect = 3e-07
 Identities = 50/186 (26%), Positives = 97/186 (52%), Gaps = 15/186 (8%)

Query: 831  KLEQLILEGNKISGICSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMNFLA 889
            +L +L +  N+I  I   +   K L++ + S N ++ L E+F    P++++ +       
Sbjct: 2    QLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESF----PELQNLTCLSVNDI 57

Query: 890  AMPFLPPS------MTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943
            ++  LP +      +  L+L +N  + +P+++  L  L  LD+ +N+I  LP  +    L
Sbjct: 58   SLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP-ESIGALL 116

Query: 944  NLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLE 1003
            +L++L    NQ+S  +L ++      +  L +S N+L+ +P EI  L +LT L +S NL 
Sbjct: 117  HLKDLWLDGNQLS--ELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNL- 173

Query: 1004 LRSFPN 1009
            L + P+
Sbjct: 174  LETIPD 179



 Score = 41.2 bits (95), Expect = 0.024
 Identities = 38/162 (23%), Positives = 76/162 (46%), Gaps = 25/162 (15%)

Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
           L++LT L ++     S P  +  +  +A+L++  N +  + + D   +   L++ +L  N
Sbjct: 46  LQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLL--TYLPDSLTQLRRLEELDLGNN 103

Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEAC 875
           ++  +PE++  ++  L+ L L+GN++S +   +  LK L  L++S+N +  L E      
Sbjct: 104 EIYNLPESIGALLH-LKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLT 162

Query: 876 PKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILN 917
                                S+T L +SQN    IP+ + N
Sbjct: 163 ---------------------SLTDLVISQNLLETIPDGLEN 183



>gi|4678722|emb|CAB41259.1|   hypothetical protein [Homo sapiens]
          Length = 481

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVM+L S G L DR+L+  +   T      +   V   ++YLH   I++RDLKP N+L  
Sbjct: 100  LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 157

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
            T   N+ I+  I D+G+++      + T+ GTPG+ APEV      Y++  D +S G++ 
Sbjct: 158  TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 214

Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755
            Y IL  G        +P  ++E E  +  K+ +   E+    W  + +  K      L++
Sbjct: 215  Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 265

Query: 1756 NPQERPT 1762
            +P ER T
Sbjct: 266  DPNERYT 272



>gi|37727969|gb|AAR02363.1|   interleukin-1 receptor-associated kinase 4 short form variant 4 [Homo
            sapiens]
 gi|37727967|gb|AAR02362.1|   interleukin-1 receptor-associated kinase 4 short form variant 3 [Homo
            sapiens]
 gi|37727965|gb|AAR02361.1|   interleukin-1 receptor-associated kinase 4 short form variant 2 [Homo
            sapiens]
 gi|37727963|gb|AAR02360.1|   interleukin-1 receptor-associated kinase 4 short form variant 1 [Homo
            sapiens]
          Length = 336

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 55/191 (28%), Positives = 95/191 (49%), Gaps = 20/191 (10%)

Query: 1593 LDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIA 1651
            LDRL   D    L+  ++ +IA   A+G+ +LH    I+RD+K  N+LL     + A  A
Sbjct: 147  LDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILL-----DEAFTA 201

Query: 1652 KIADYGIAQYCCRMG--IKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT- 1706
            KI+D+G+A+   +    + TS   GT  + APE  RG +    ++D+YSFG++L +I+T 
Sbjct: 202  KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 259

Query: 1707 -------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759
                      +++  +K   E +E  I+  +   + +        +  +  QCL E   +
Sbjct: 260  LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNK 319

Query: 1760 RPTSAQVFDIL 1770
            RP   +V  +L
Sbjct: 320  RPDIKKVQQLL 330



>gi|4507743|ref|NP_003319.1|   TXK tyrosine kinase [Homo sapiens]
 gi|7434388|pir||I84483   protein-tyrosine kinase (EC 2.7.1.112) TXK - human
 gi|1351326|sp|P42681|TXK_HUMAN   Tyrosine-protein kinase TXK
 gi|684986|gb|AAA74557.1|   tyrosine kinase
          Length = 527

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 51/192 (26%), Positives = 95/192 (49%), Gaps = 16/192 (8%)

Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            +P  +V E    G L   L+++K  L + +   +   + +G+ YL     I+RDL   N 
Sbjct: 337  KPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNC 396

Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTP---GFRAPEVARGNVIYNQQADVY 1695
            L+     ++  I KI+D+G+ +Y       +S G      +  PEV   N  Y+ ++DV+
Sbjct: 397  LV-----SSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK-YSSKSDVW 450

Query: 1696 SFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPM-VEKLIKQCLK 1754
            SFG+L++++ T G      + F N+   L++   + +  + Y     PM + +++  C  
Sbjct: 451  SFGVLMWEVFTEG-----KMPFENK-SNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504

Query: 1755 ENPQERPTSAQV 1766
            E P+ RPT A++
Sbjct: 505  EKPEGRPTFAEL 516



>gi|16755792|gb|AAL28100.1|   calcium/calmodulin-dependent protein kinase I gamma [Homo sapiens]
          Length = 476

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVM+L S G L DR+L+  +   T      +   V   ++YLH   I++RDLKP N+L  
Sbjct: 95   LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
            T   N+ I+  I D+G+++      + T+ GTPG+ APEV      Y++  D +S G++ 
Sbjct: 153  TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209

Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755
            Y IL  G        +P  ++E E  +  K+ +   E+    W  + +  K      L++
Sbjct: 210  Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260

Query: 1756 NPQERPT 1762
            +P ER T
Sbjct: 261  DPNERYT 267



>gi|47169343|pdb|1UWJ|B   Chain B, The Complex Of Mutant V599e B-Raf And Bay439006
 gi|47169342|pdb|1UWJ|A   Chain A, The Complex Of Mutant V599e B-Raf And Bay439006
          Length = 276

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 58/172 (33%), Positives = 89/172 (51%), Gaps = 17/172 (9%)

Query: 1612 IALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG----I 1667
            IA   A G+ YLH+  II+RDLK +N+ L     +  +  KI D+G+A    R       
Sbjct: 109  IARQTAQGMDYLHAKSIIHRDLKSNNIFL-----HEDLTVKIGDFGLATEKSRWSGSHQF 163

Query: 1668 KTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELE 1725
            +   G+  + APEV R      Y+ Q+DVY+FG++LY+++ TG      +   ++   + 
Sbjct: 164  EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELM-TGQLPYSNINNRDQIIFMV 222

Query: 1726 IQGKL-PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELV 1776
             +G L PD  K     P  M ++L+ +CLK+   ERP   Q   IL S EL+
Sbjct: 223  GRGYLSPDLSKVRSNCPKAM-KRLMAECLKKKRDERPLFPQ---ILASIELL 270



>gi|56404655|sp|Q96NX5|KCC1G_HUMAN   Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase IG)
            (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI
            gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
          Length = 476

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 21/187 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVM+L S G L DR+L+  +   T      +   V   ++YLH   I++RDLKP N+L  
Sbjct: 95   LVMQLVSGGELFDRILE--RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYL 152

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
            T   N+ I+  I D+G+++      + T+ GTPG+ APEV      Y++  D +S G++ 
Sbjct: 153  TPEENSKIM--ITDFGLSKMEQNGIMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIT 209

Query: 1702 YDILTTGGRIVEGLKFPNEFDELE--IQGKLPDPVKEYGCAPWPMVEKLIK----QCLKE 1755
            Y IL  G        +P  ++E E  +  K+ +   E+    W  + +  K      L++
Sbjct: 210  Y-ILLCG--------YPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK 260

Query: 1756 NPQERPT 1762
            +P ER T
Sbjct: 261  DPNERYT 267



>gi|5822499|pdb|2SRC|    Crystal Structure Of Human Tyrosine-Protein Kinase C-Src, In Complex
            With Amp-Pnp
 gi|2392337|pdb|1FMK|    Crystal Structure Of Human Tyrosine-Protein Kinase C-Src
          Length = 452

 Score = 67.8 bits (164), Expect = 2e-10
 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  +V E  SKGSL   L+ +     R  Q   +A  +A G+ Y+     ++RDL+  N+
Sbjct: 252  PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 311

Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690
            L+        ++ K+AD+G+A      +Y  R G K       + APE A    +Y +  
Sbjct: 312  LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 359

Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LL ++ T G     G+      D++E   ++P P +   C     +  L+
Sbjct: 360  IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 414

Query: 1750 KQCLKENPQERPT 1762
             QC ++ P+ERPT
Sbjct: 415  CQCWRKEPEERPT 427



>gi|56208156|emb|CAI22301.1|   FYN oncogene related to SRC, FGR, YES [Homo sapiens]
 gi|23510362|ref|NP_694592.1|   protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%)

Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597
            T+    ++P+  L +      L +D+L       + +    P  +V E  +KGSL D L 
Sbjct: 297  TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 352

Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657
              +  +L       +A  VA G+ Y+     I+RDL+  N+L+        +I KIAD+G
Sbjct: 353  DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 407

Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708
            +A      +Y  R G K       + APE A    +Y +   ++DV+SFG+LL +++T G
Sbjct: 408  LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 460

Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
                 G+      +++E   ++P P       P  + E +I  C K++P+ERPT
Sbjct: 461  RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 509



>gi|56208155|emb|CAI22300.1|   FYN oncogene related to SRC, FGR, YES [Homo sapiens]
 gi|4503823|ref|NP_002028.1|   protein-tyrosine kinase fyn isoform a [Homo sapiens]
 gi|66783|pir||TVHUSY   protein-tyrosine kinase (EC 2.7.1.112) fyn, splice form B [validated]
            - human
 gi|181172|gb|AAC08285.1|   c-syn protooncogene [Homo sapiens]
 gi|125370|sp|P06241|FYN_HUMAN   Proto-oncogene tyrosine-protein kinase FYN (P59-FYN) (SYN) (SLK)
          Length = 537

 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%)

Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597
            T+    ++P+  L +      L +D+L       + +    P  +V E  +KGSL D L 
Sbjct: 300  TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355

Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657
              +  +L       +A  VA G+ Y+     I+RDL+  N+L+        +I KIAD+G
Sbjct: 356  DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 410

Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708
            +A      +Y  R G K       + APE A    +Y +   ++DV+SFG+LL +++T G
Sbjct: 411  LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 463

Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
                 G+      +++E   ++P P       P  + E +I  C K++P+ERPT
Sbjct: 464  RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 512



>gi|5031689|ref|NP_005804.1|   protein kinase D3 [Homo sapiens]
 gi|12230239|sp|O94806|KPCN_HUMAN   Protein kinase C, nu type (nPKC-nu) (Protein kinase EPK2)
 gi|4115769|dbj|BAA36514.1|   serine/threonine kinase [Homo sapiens]
          Length = 890

 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 56/207 (27%), Positives = 93/207 (44%), Gaps = 30/207 (14%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME      L+ +L  +K+ L   +   +   +   LR LH   I++ DLKP NVLL +
Sbjct: 650  VVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS 709

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              P   +  K+ D+G A+       + S  GTP + APEV R    YN+  D++S G+++
Sbjct: 710  AEPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKG-YNRSLDMWSVGVII 766

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            Y  L+          FP   DE +I  ++ +    Y   PW                 R 
Sbjct: 767  YVSLSG--------TFPFNEDE-DINDQIQNAAFMYPPNPW-----------------RE 800

Query: 1762 TSAQVFDILNSAELVCLTRRILLPKNV 1788
             S +  D++N+   V + +R  + K++
Sbjct: 801  ISGEAIDLINNLLQVKMRKRYSVDKSL 827



>gi|56208154|emb|CAI22299.1|   FYN oncogene related to SRC, FGR, YES [Homo sapiens]
          Length = 485

 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%)

Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597
            T+    ++P+  L +      L +D+L       + +    P  +V E  +KGSL D L 
Sbjct: 248  TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 303

Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657
              +  +L       +A  VA G+ Y+     I+RDL+  N+L+        +I KIAD+G
Sbjct: 304  DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 358

Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708
            +A      +Y  R G K       + APE A    +Y +   ++DV+SFG+LL +++T G
Sbjct: 359  LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 411

Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
                 G+      +++E   ++P P       P  + E +I  C K++P+ERPT
Sbjct: 412  RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 460



>gi|21618480|gb|AAH32496.1|   Protein-tyrosine kinase fyn, isoform c [Homo sapiens]
 gi|23510364|ref|NP_694593.1|   protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 31/234 (13%)

Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597
            T+    ++P+  L +      L +D+L       + +    P  +V E  +KGSL D L 
Sbjct: 245  TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 300

Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657
              +  +L       +A  VA G+ Y+     I+RDL+  N+L+        +I KIAD+G
Sbjct: 301  DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 355

Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708
            +A      +Y  R G K       + APE A    +Y +   ++DV+SFG+LL +++T G
Sbjct: 356  LARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFTIKSDVWSFGILLTELVTKG 408

Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
                 G+      +++E   ++P P       P  + E +I  C K++P+ERPT
Sbjct: 409  RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 457



>gi|18265389|gb|AAL67158.1|   zipper protein kinase [Homo sapiens]
          Length = 859

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            ++ME  ++G L  +L+  +  +T +L    ++ +A G+ YLH   II+RDLK  N+L+  
Sbjct: 188  ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
             Y +   + KI+D+G ++       K S  GT  + APEV R   + +++ D++SFG++L
Sbjct: 245  TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300

Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753
            +++LT            I+ G+   +    L +    PD  K            L++QC 
Sbjct: 301  WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347

Query: 1754 KENPQERPTSAQV 1766
               P+ RP+  Q+
Sbjct: 348  NSKPRNRPSFRQI 360



>gi|37181368|gb|AAQ88498.1|   densin hlg [Homo sapiens]
 gi|55665039|emb|CAH72253.1|   OTTHUMP00000012531 [Homo sapiens]
 gi|16307072|gb|AAH09613.1|   Hypothetical protein MGC14816 [Homo sapiens]
 gi|21389431|ref|NP_653221.1|   hypothetical protein MGC14816 [Homo sapiens]
          Length = 335

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 70/247 (28%), Positives = 104/247 (42%), Gaps = 55/247 (22%)

Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT-LKQ 810
           S+ L L  L    LH       P ++ +   +  LD+SRN I     + P +   T L++
Sbjct: 77  SSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE---IPPGIGLLTRLQE 133

Query: 811 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICS-PLRLKELKILNLSKNHISSLSE 869
             LSYN++  VP+ L++    LE+L L  N+   IC  P  L  L               
Sbjct: 134 LILSYNKIKTVPKELSNCA-SLEKLELAVNR--DICDLPQELSNLL-------------- 176

Query: 870 NFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSN 929
                                       +T L LS N F+ IP A+LN+P L  LDM SN
Sbjct: 177 ---------------------------KLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSN 209

Query: 930 DIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC 989
            ++ LP     +  NL  L    N+I+   L +       +  L LS+NKL++IP    C
Sbjct: 210 KLEQLPDTIE-RMQNLHTLWLQRNEITC--LPQTISNMKNLGTLVLSNNKLQDIPV---C 263

Query: 990 LENLTSL 996
           +E + +L
Sbjct: 264 MEEMANL 270



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 34/123 (27%), Positives = 64/123 (52%), Gaps = 3/123 (2%)

Query: 900  ILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILD 959
            ILK+ + ++  +P ++L L  L+   +    +  +P     +  NL  L  S N IS  +
Sbjct: 64   ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIP-EFIGRFQNLIVLDLSRNTIS--E 120

Query: 960  LSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWD 1019
            +     L +R+++L LS+NK+K +P E+    +L  L+++ N ++   P E+  L K+  
Sbjct: 121  IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH 180

Query: 1020 LPL 1022
            L L
Sbjct: 181  LDL 183



 Score = 44.3 bits (103), Expect = 0.003
 Identities = 32/109 (29%), Positives = 56/109 (51%), Gaps = 8/109 (7%)

Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
           L  LTHLDL  N FT+ P  +L M  +  LD+  N +    + D   +   L    L  N
Sbjct: 175 LLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKL--EQLPDTIERMQNLHTLWLQRN 232

Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKN 862
           +++ +P+ +++ ++ L  L+L  NK+  I  P+ ++E   L+ +N   N
Sbjct: 233 EITCLPQTISN-MKNLGTLVLSNNKLQDI--PVCMEEMANLRFVNFRDN 278



 Score = 39.7 bits (91), Expect = 0.069
 Identities = 37/136 (27%), Positives = 62/136 (45%), Gaps = 11/136 (8%)

Query: 894  LPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSN-DIQYLPGPAHWKSLNLR 946
            +PP + +L       LS NK   +P+ + N   L  L+++ N DI  LP       L L 
Sbjct: 121  IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELS-NLLKLT 179

Query: 947  ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006
             L  S N  + + L+        +E L +  NKL+++P  I  ++NL +L +  N E+  
Sbjct: 180  HLDLSMNDFTTIPLA--VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRN-EITC 236

Query: 1007 FPNEMGKLSKIWDLPL 1022
             P  +  +  +  L L
Sbjct: 237  LPQTISNMKNLGTLVL 252



>gi|4506075|ref|NP_002733.1|   protein kinase D1 [Homo sapiens]
 gi|1362911|pir||A53215   protein kinase C (EC 2.7.1.-) mu precursor - human
 gi|2499575|sp|Q15139|KPCM_HUMAN   Protein kinase C, mu type (nPKC-mu) (Protein kinase D)
 gi|438373|emb|CAA53384.1|   protein kinase C mu [Homo sapiens]
          Length = 912

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 50/161 (31%), Positives = 78/161 (48%), Gaps = 13/161 (8%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME      L+ +L  +K  L   +   +   +   LR+LH   I++ DLKP NVLL +
Sbjct: 657  VVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS 716

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              P   +  K+ D+G A+       + S  GTP + APEV R N  YN+  D++S G+++
Sbjct: 717  ADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWSVGVII 773

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPW 1742
            Y  L+          FP   DE +I  ++ +    Y   PW
Sbjct: 774  YVSLSG--------TFPFNEDE-DIHDQIQNAAFMYPPNPW 805



>gi|29476775|gb|AAH50050.1|   MAP3K12 protein [Homo sapiens]
          Length = 567

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            ++ME  ++G L  +L+  +  +T +L    ++ +A G+ YLH   II+RDLK  N+L+  
Sbjct: 221  ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 277

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
             Y +   + KI+D+G ++       K S  GT  + APEV R   + +++ D++SFG++L
Sbjct: 278  TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 333

Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753
            +++LT            I+ G+   +    L +    PD  K            L++QC 
Sbjct: 334  WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 380

Query: 1754 KENPQERPTSAQV 1766
               P+ RP+  Q+
Sbjct: 381  NSKPRNRPSFRQI 393



>gi|56204512|emb|CAI23271.1|   protein kinase N2 [Homo sapiens]
 gi|5453974|ref|NP_006247.1|   protein kinase N2 [Homo sapiens]
 gi|7446420|pir||S67527   protein kinase (EC 2.7.1.-) PRK2 - human
 gi|1000125|gb|AAC50208.1|   PRK2
 gi|6225859|sp|Q16513|PKL2_HUMAN   Protein kinase N2 (Protein kinase C-like 2) (Protein-kinase C-related
            kinase 2)
 gi|914100|gb|AAB33346.1|   protein kinase PRK2 [Homo sapiens]
 gi|1093487|prf||2104208B   protein kinase C-related kinase:ISOTYPE=PRK2.3
          Length = 984

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 59/179 (32%), Positives = 86/179 (48%), Gaps = 17/179 (9%)

Query: 1584 VMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643
            VME A+ G L   +  D  S  R + +  A  V  GL+YLH   I+YRDLK  N+LL T 
Sbjct: 736  VMEYAAGGDLMMHIHTDVFSEPRAVFY--AACVVLGLQYLHEHKIVYRDLKLDNLLLDT- 792

Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKTSE--GTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
                    KIAD+G+ +     G +TS   GTP F APEV      Y +  D +  G+L+
Sbjct: 793  ----EGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT-ETSYTRAVDWWGLGVLI 847

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER 1760
            Y++L      V    FP + DE E+   + +    Y          ++++ L+ NP+ R
Sbjct: 848  YEML------VGESPFPGD-DEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERR 899



>gi|55665040|emb|CAH72254.1|   OTTHUMP00000012587 [Homo sapiens]
          Length = 339

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 70/247 (28%), Positives = 104/247 (42%), Gaps = 55/247 (22%)

Query: 752 SNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT-LKQ 810
           S+ L L  L    LH       P ++ +   +  LD+SRN I     + P +   T L++
Sbjct: 77  SSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISE---IPPGIGLLTRLQE 133

Query: 811 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICS-PLRLKELKILNLSKNHISSLSE 869
             LSYN++  VP+ L++    LE+L L  N+   IC  P  L  L               
Sbjct: 134 LILSYNKIKTVPKELSNCA-SLEKLELAVNR--DICDLPQELSNLL-------------- 176

Query: 870 NFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSN 929
                                       +T L LS N F+ IP A+LN+P L  LDM SN
Sbjct: 177 ---------------------------KLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSN 209

Query: 930 DIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC 989
            ++ LP     +  NL  L    N+I+   L +       +  L LS+NKL++IP    C
Sbjct: 210 KLEQLPDTIE-RMQNLHTLWLQRNEITC--LPQTISNMKNLGTLVLSNNKLQDIPV---C 263

Query: 990 LENLTSL 996
           +E + +L
Sbjct: 264 MEEMANL 270



 Score = 51.2 bits (121), Expect = 2e-05
 Identities = 34/123 (27%), Positives = 64/123 (52%), Gaps = 3/123 (2%)

Query: 900  ILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILD 959
            ILK+ + ++  +P ++L L  L+   +    +  +P     +  NL  L  S N IS  +
Sbjct: 64   ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIP-EFIGRFQNLIVLDLSRNTIS--E 120

Query: 960  LSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWD 1019
            +     L +R+++L LS+NK+K +P E+    +L  L+++ N ++   P E+  L K+  
Sbjct: 121  IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTH 180

Query: 1020 LPL 1022
            L L
Sbjct: 181  LDL 183



 Score = 44.3 bits (103), Expect = 0.003
 Identities = 32/109 (29%), Positives = 56/109 (51%), Gaps = 8/109 (7%)

Query: 757 LKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN 816
           L  LTHLDL  N FT+ P  +L M  +  LD+  N +    + D   +   L    L  N
Sbjct: 175 LLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKL--EQLPDTIERMQNLHTLWLQRN 232

Query: 817 QLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKN 862
           +++ +P+ +++ ++ L  L+L  NK+  I  P+ ++E   L+ +N   N
Sbjct: 233 EITCLPQTISN-MKNLGTLVLSNNKLQDI--PVCMEEMANLRFVNFRDN 278



 Score = 39.7 bits (91), Expect = 0.069
 Identities = 37/136 (27%), Positives = 62/136 (45%), Gaps = 11/136 (8%)

Query: 894  LPPSMTILK------LSQNKFSCIPEAILNLPHLRSLDMSSN-DIQYLPGPAHWKSLNLR 946
            +PP + +L       LS NK   +P+ + N   L  L+++ N DI  LP       L L 
Sbjct: 121  IPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELS-NLLKLT 179

Query: 947  ELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRS 1006
             L  S N  + + L+        +E L +  NKL+++P  I  ++NL +L +  N E+  
Sbjct: 180  HLDLSMNDFTTIPLA--VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRN-EITC 236

Query: 1007 FPNEMGKLSKIWDLPL 1022
             P  +  +  +  L L
Sbjct: 237  LPQTISNMKNLGTLVL 252



>gi|2641948|dbj|BAA23592.1|   aurora/IPL1-related kinase [Homo sapiens]
          Length = 402

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 18/188 (9%)

Query: 1583 LVMELASKGSLDRLLQQ-DKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            L++E A  G++ R LQ+  K    RT    +   +A+ L Y HS  +I+RD+KP N+LL 
Sbjct: 207  LILEYAPLGTVYRELQKLSKFDEQRTAN--LYNRIANALSYCHSKRVIHRDIKPENLLL- 263

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
                 +A   KIAD+G + +       T  GT  +  PE+  G  +++++ D++S G+L 
Sbjct: 264  ----GSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGVLC 318

Query: 1702 YDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER 1760
            Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP +R
Sbjct: 319  YEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPSQR 370

Query: 1761 PTSAQVFD 1768
            P   +V +
Sbjct: 371  PMLREVLE 378



>gi|47458815|ref|NP_996790.2|   protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2
            [Homo sapiens]
          Length = 565

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 36/96 (37%), Positives = 58/96 (60%), Gaps = 6/96 (6%)

Query: 1611 RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG-IKT 1669
            R+   +  G+ Y H  M+++RDLKP NVLL     +A + AKIAD+G++        ++T
Sbjct: 135  RLFQQILSGVDYCHRHMVVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFLRT 189

Query: 1670 SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDIL 1705
            S G+P + APEV  G +    + D++S G++LY +L
Sbjct: 190  SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 225



>gi|21735552|ref|NP_006292.2|   mitogen-activated protein kinase kinase kinase 12 [Homo sapiens]
          Length = 859

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            ++ME  ++G L  +L+  +  +T +L    ++ +A G+ YLH   II+RDLK  N+L+  
Sbjct: 188  ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
             Y +   + KI+D+G ++       K S  GT  + APEV R   + +++ D++SFG++L
Sbjct: 245  TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300

Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753
            +++LT            I+ G+   +    L +    PD  K            L++QC 
Sbjct: 301  WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347

Query: 1754 KENPQERPTSAQV 1766
               P+ RP+  Q+
Sbjct: 348  NSKPRNRPSFRQI 360



>gi|29124503|gb|AAH48980.1|   PRKAA1 protein [Homo sapiens]
          Length = 574

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 36/96 (37%), Positives = 58/96 (60%), Gaps = 6/96 (6%)

Query: 1611 RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG-IKT 1669
            R+   +  G+ Y H  M+++RDLKP NVLL     +A + AKIAD+G++        ++T
Sbjct: 144  RLFQQILSGVDYCHRHMVVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFLRT 198

Query: 1670 SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDIL 1705
            S G+P + APEV  G +    + D++S G++LY +L
Sbjct: 199  SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL 234



>gi|4104413|gb|AAD02031.1|   Eph-like receptor tyrosine kinase hEphB1b [Homo sapiens]
          Length = 973

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 60/266 (22%), Positives = 119/266 (44%), Gaps = 32/266 (12%)

Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            RP M++ E    G+LD  L+Q+    T      +   +A G++YL     ++RDL   N+
Sbjct: 680  RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 739

Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688
            L+     N+ ++ K++D+G+++Y   +   TS+ T            + APE       +
Sbjct: 740  LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRK-F 790

Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748
               +DV+S+G+ ++++++ G R    +   +  + +E   +LP P     C     + +L
Sbjct: 791  TSASDVWSYGIRMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPT---DCP--AALHQL 845

Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803
            +  C +++   RP  A++ + L     N A L  +     +P   +++  +         
Sbjct: 846  MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 905

Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829
              WL      + + SFL   T G+TS
Sbjct: 906  DDWLSAIKMVQYRDSFL---TAGFTS 928



>gi|2136035|pir||I38138   protein-serine kinase (EC 2.7.1.-) PSK-H1 - human (fragment)
          Length = 319

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 49/129 (37%), Positives = 74/129 (57%), Gaps = 11/129 (8%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VMELA+ G L DR++   K S T     R+   V DG+RYLH+  I +RDLKP N+L +
Sbjct: 170  MVMELATGGELFDRIIA--KGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYY 227

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG----IKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697
                ++ II  I D+G+A    + G    +KT+ GTP + APEV      Y    D+++ 
Sbjct: 228  HPGTDSKII--ITDFGLAS-ARKKGDDCLMKTTCGTPEYIAPEVLVRKP-YTNSVDMWAL 283

Query: 1698 GLLLYDILT 1706
            G++ Y +L+
Sbjct: 284  GVIAYILLS 292



>gi|631347|pir||JC2363   protein kinase (EC 2.7.1.37) ZPK - human
          Length = 668

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            ++ME  ++G L  +L+  +  +T +L    ++ +A G+ YLH   II+RDLK  N+L+  
Sbjct: 188  ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
             Y +   + KI+D+G ++       K S  GT  + APEV R   + +++ D++SFG++L
Sbjct: 245  TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300

Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753
            +++LT            I+ G+   +    L +    PD  K            L++QC 
Sbjct: 301  WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347

Query: 1754 KENPQERPTSAQV 1766
               P+ RP+  Q+
Sbjct: 348  NSKPRNRPSFRQI 360



>gi|18202489|sp|Q12852|M3K12_HUMAN   Mitogen-activated protein kinase kinase kinase 12 (Leucine-zipper
            protein kinase) (ZPK)
 gi|561543|gb|AAA67343.1|   serine/threonine protein kinase
          Length = 859

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 54/193 (27%), Positives = 97/193 (50%), Gaps = 29/193 (15%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            ++ME  ++G L  +L+  +  +T +L    ++ +A G+ YLH   II+RDLK  N+L+  
Sbjct: 188  ILMEFCAQGQLYEVLRAGRP-VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLI-- 244

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
             Y +   + KI+D+G ++       K S  GT  + APEV R   + +++ D++SFG++L
Sbjct: 245  TYDD---VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEKVDIWSFGVVL 300

Query: 1702 YDILT--------TGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCL 1753
            +++LT            I+ G+   +    L +    PD  K            L++QC 
Sbjct: 301  WELLTGEIPYKDVDSSAIIWGV--GSNSLHLPVPSSCPDGFK-----------ILLRQCW 347

Query: 1754 KENPQERPTSAQV 1766
               P+ RP+  Q+
Sbjct: 348  NSKPRNRPSFRQI 360



>gi|20151029|pdb|1KSW|A   Chain A, Structure Of Human C-Src Tyrosine Kinase (Thr338gly Mutant)
            In Complex With N6-Benzyl Adp
          Length = 452

 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 57/193 (29%), Positives = 95/193 (49%), Gaps = 27/193 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            P  +V E  SKGSL   L+ +     R  Q   +A  +A G+ Y+     ++RDL+  N+
Sbjct: 252  PIYIVGEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 311

Query: 1639 LLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ-- 1690
            L+        ++ K+AD+G+A      +Y  R G K       + APE A    +Y +  
Sbjct: 312  LV-----GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAA----LYGRFT 359

Query: 1691 -QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLI 1749
             ++DV+SFG+LL ++ T G     G+      D++E   ++P P +   C     +  L+
Sbjct: 360  IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CP--ESLHDLM 414

Query: 1750 KQCLKENPQERPT 1762
             QC ++ P+ERPT
Sbjct: 415  CQCWRKEPEERPT 427



>gi|1362858|pir||A56708   MAPK/ERK kinase 5 - human
          Length = 444

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 55/181 (30%), Positives = 80/181 (44%), Gaps = 19/181 (10%)

Query: 1586 ELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYP 1645
            E    GSLD     D   +   +  RIA+ V  GL YL S  I++RD+KP N+L+     
Sbjct: 242  EFMDGGSLD-----DIGKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLV----- 291

Query: 1646 NAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDIL 1705
            N     K+ D+G++        KT  GT  + APE   G   Y   +DV+S G+   +I 
Sbjct: 292  NTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQ-YGIHSDVWSLGISFMEIQ 350

Query: 1706 TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQ 1765
               G ++         DE         PV   G    P V   I QC+++ P+ERP   +
Sbjct: 351  KNQGSLMPLQLLQCIVDE-------DSPVLPVGEFSEPFVH-FITQCMRKQPKERPAPEE 402

Query: 1766 V 1766
            +
Sbjct: 403  L 403



>gi|56203182|emb|CAC17574.2|   protein kinase, AMP-activated, alpha 2 catalytic subunit [Homo
            sapiens]
 gi|47481319|gb|AAH69823.1|   AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens]
 gi|47481295|gb|AAH69680.1|   AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens]
 gi|47479751|gb|AAH69740.1|   AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens]
 gi|46877068|ref|NP_006243.2|   AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens]
 gi|1082205|pir||S51025   [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase (EC 2.7.1.109)
            - human
 gi|786491|gb|AAB32732.1|   AMP-activated protein kinase, AMPK [human, skeletal muscle, Peptide,
            552 aa]
 gi|20178276|sp|P54646|AAPK2_HUMAN   5'-AMP-activated protein kinase, catalytic alpha-2 chain (AMPK
            alpha-2 chain)
          Length = 552

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 9/125 (7%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VME  S G L D + +  +         R+   +   + Y H  M+++RDLKP NVLL 
Sbjct: 91   MVMEYVSGGELFDYICKHGRVEEMEA--RRLFQQILSAVDYCHRHMVVHRDLKPENVLL- 147

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700
                +A + AKIAD+G++        ++TS G+P + APEV  G +    + D++S G++
Sbjct: 148  ----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVI 203

Query: 1701 LYDIL 1705
            LY +L
Sbjct: 204  LYALL 208



>gi|758367|gb|AAA64745.1|   AMP-activated protein kinase
          Length = 552

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 42/125 (33%), Positives = 68/125 (54%), Gaps = 9/125 (7%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            +VME  S G L D + +  +         R+   +   + Y H  M+++RDLKP NVLL 
Sbjct: 91   MVMEYVSGGELFDYICKHGRVEEMEA--RRLFQQILSAVDYCHRHMVVHRDLKPENVLL- 147

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMG-IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700
                +A + AKIAD+G++        ++TS G+P + APEV  G +    + D++S G++
Sbjct: 148  ----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYTAPEVISGRLYAGPEVDIWSCGVI 203

Query: 1701 LYDIL 1705
            LY +L
Sbjct: 204  LYALL 208



>gi|338228|gb|AAA36615.1|   src-like tyrosine kinase (put.); putative
          Length = 537

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 64/234 (27%), Positives = 108/234 (46%), Gaps = 31/234 (13%)

Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597
            T+    ++P+  L +      L +D+L       + +    P  +V E  +KGSL D L 
Sbjct: 300  TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355

Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657
              +  +L       +A  VA G+ Y+     I+RDL+  N+L+        +I KIAD+G
Sbjct: 356  DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 410

Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708
            +A      +Y  R G K       F     A    +Y +   ++DV+SFG+LL +++T G
Sbjct: 411  LARLIEDNEYTARQGAK-------FPIKWTAPERALYGRFTIKSDVWSFGILLTELVTKG 463

Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
                 G+      +++E   ++P P       P  + E +I  C K++P+ERPT
Sbjct: 464  RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 512



>gi|37182866|gb|AAQ89233.1|   LRRC5 [Homo sapiens]
          Length = 501

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%)

Query: 741  LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794
            L  C   +++ + S     L  L +        P+  YLLK    +  I NL+   N + 
Sbjct: 163  LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 221

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849
              + L+   +   LK  ++  N L+ VP N+TDV   L +L++  +G K+   + +   +
Sbjct: 222  --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 278

Query: 850  RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
             + EL++ N     I     SLS N  E   K  +       ++        +T LKL  
Sbjct: 279  NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 335

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP +I ++ +L SL  S+N ++ LP  A +    LR L  S+N IS++ +  +  
Sbjct: 336  NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 392

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            L   ++ LH++ NK+  +P ++     L +L++  N  + S P ++G+LS++  L L
Sbjct: 393  LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 448



 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%)

Query: 683  FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737
            +S + + +   ++ IPD   D  F      Q D L S+   G FL +   N +       
Sbjct: 38   YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 96

Query: 738  DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797
            +   ++   ++ R++           +LH    +  P  +  ++   +LDV + ++ P  
Sbjct: 97   EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 146

Query: 798  VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833
             +   +   T L++ +L +          SF+ ++L       TDV E          L 
Sbjct: 147  KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 206

Query: 834  QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887
            +L L      E NK+ G+ S   L+ LKIL++ K++++ +  N  +  P +       + 
Sbjct: 207  ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 265

Query: 888  --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943
              L  +  L   M +  L+L   +   IP AI +L +L+ LD+ SN+I+ +     ++ L
Sbjct: 266  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 325

Query: 944  N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002
              L  L   HN+I  +  S        +E L+ S+NKL+ +P  +  L+ L  LDVSYN 
Sbjct: 326  KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 382

Query: 1003 ELRSFPNEMGKLSKIWDL 1020
             +   P E+G L  +  L
Sbjct: 383  NISMIPIEIGLLQNLQHL 400



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%)

Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779
           S L K  SN   V       V+      L   ++   + ++  L+L + +    P  +  
Sbjct: 240 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 299

Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839
           +S +  LD+  N+I     +        L    L +N++  +P ++T V + LE L    
Sbjct: 300 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 358

Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896
           NK+  +  +   L++L+ L++S N+IS +      L+    +     +++ L    F   
Sbjct: 359 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 418

Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935
            +  L L QN  + +PE +  L  L  L++  N +  LP
Sbjct: 419 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 457



>gi|23241685|gb|AAH34988.1|   ULK2 protein [Homo sapiens]
          Length = 1036

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 52/131 (39%), Positives = 70/131 (53%), Gaps = 13/131 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVME  + G L   LQ        T+  R+ LH +A  +R LHS  II+RDLKP N+LL 
Sbjct: 83   LVMEYCNGGDLADYLQAKGTLSEDTI--RVFLHQIAAAMRILHSKGIIHRDLKPQNILL- 139

Query: 1642 TLYPN------AAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADV 1694
              Y N      + I  KIAD+G A+Y    M   T  G+P + APEV      Y+ +AD+
Sbjct: 140  -SYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQ-HYDAKADL 197

Query: 1695 YSFGLLLYDIL 1705
            +S G ++Y  L
Sbjct: 198  WSIGTVIYQCL 208



>gi|22760350|dbj|BAC11161.1|   unnamed protein product [Homo sapiens]
          Length = 546

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814
            ++L  L +        P ++  +  +  L ++ N   +    +V+D   +   LK   L 
Sbjct: 229  ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 288

Query: 815  YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865
             N LS +P+ +TDV   L++L +  EG K+   + +     L EL+++      I     
Sbjct: 289  SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 347

Query: 866  --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905
                     L +N L+   ++ SF             N +A +P    ++T L+   L++
Sbjct: 348  SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 407

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP  +     LR LD+S N++ +LP        NL+ L  + N+I  L    + +
Sbjct: 408  NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 464

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013
               ++  LHL +N L+ +P  +G L NLT +++  N  L   P E+G+
Sbjct: 465  QCRKLRALHLGNNVLRSLPSRVGELTNLTQIELRGN-RLECLPVELGE 511



 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%)

Query: 748  LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807
            L +    LT  +   L+LH    +  P  +  +     L+V + ++ P V + P++   T
Sbjct: 149  LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 205

Query: 808  -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843
             LK+  L +         L+F+ ENL       TD+ E          LE+L L GN  +
Sbjct: 206  GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 265

Query: 844  G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889
                  +   LR LK LK+L L K+++S L +   +    ++  S          +N L 
Sbjct: 266  ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 324

Query: 890  AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946
             M     ++T L+L +     IP +I +L +L+ +D+  N+   I+ +    H   L   
Sbjct: 325  KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 380

Query: 947  ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987
            +L ++H      QI  L   E+ YL  +++EK             L LSHN L  +P +I
Sbjct: 381  KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 440

Query: 988  GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            G L+NL +L ++ N  + + P E+ +  K+  L L
Sbjct: 441  GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 474



>gi|55663684|emb|CAH72226.1|   leucine rich repeat containing 5 [Homo sapiens]
 gi|34222199|ref|NP_060573.2|   leucine rich repeat containing 5 [Homo sapiens]
 gi|33988925|gb|AAH24159.2|   Leucine rich repeat containing 5 [Homo sapiens]
 gi|51701663|sp|Q7L1W4|LRR5_HUMAN   Leucine-rich repeat-containing protein 5 precursor (UNQ213/PRO239)
          Length = 858

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%)

Query: 741  LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794
            L  C   +++ + S     L  L +        P+  YLLK    +  I NL+   N + 
Sbjct: 520  LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 578

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849
              + L+   +   LK  ++  N L+ VP N+TDV   L +L++  +G K+   + +   +
Sbjct: 579  --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 635

Query: 850  RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
             + EL++ N     I     SLS N  E   K  +       ++        +T LKL  
Sbjct: 636  NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 692

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP +I ++ +L SL  S+N ++ LP  A +    LR L  S+N IS++ +  +  
Sbjct: 693  NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 749

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            L   ++ LH++ NK+  +P ++     L +L++  N  + S P ++G+LS++  L L
Sbjct: 750  LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 805



 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%)

Query: 683  FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737
            +S + + +   ++ IPD   D  F      Q D L S+   G FL +   N +       
Sbjct: 395  YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 453

Query: 738  DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797
            +   ++   ++ R++           +LH    +  P  +  ++   +LDV + ++ P  
Sbjct: 454  EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 503

Query: 798  VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833
             +   +   T L++ +L +          SF+ ++L       TDV E          L 
Sbjct: 504  KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 563

Query: 834  QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887
            +L L      E NK+ G+ S   L+ LKIL++ K++++ +  N  +  P +       + 
Sbjct: 564  ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 622

Query: 888  --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943
              L  +  L   M +  L+L   +   IP AI +L +L+ LD+ SN+I+ +     ++ L
Sbjct: 623  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 682

Query: 944  N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002
              L  L   HN+I  +  S        +E L+ S+NKL+ +P  +  L+ L  LDVSYN 
Sbjct: 683  KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 739

Query: 1003 ELRSFPNEMGKLSKIWDL 1020
             +   P E+G L  +  L
Sbjct: 740  NISMIPIEIGLLQNLQHL 757



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%)

Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779
           S L K  SN   V       V+      L   ++   + ++  L+L + +    P  +  
Sbjct: 597 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656

Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839
           +S +  LD+  N+I     +        L    L +N++  +P ++T V + LE L    
Sbjct: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 715

Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896
           NK+  +  +   L++L+ L++S N+IS +      L+    +     +++ L    F   
Sbjct: 716 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775

Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935
            +  L L QN  + +PE +  L  L  L++  N +  LP
Sbjct: 776 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814



>gi|7022525|dbj|BAA91631.1|   unnamed protein product [Homo sapiens]
          Length = 682

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%)

Query: 741  LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794
            L  C   +++ + S     L  L +        P+  YLLK    +  I NL+   N + 
Sbjct: 344  LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 402

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849
              + L+   +   LK  ++  N L+ VP N+TDV   L +L++  +G K+   + +   +
Sbjct: 403  --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 459

Query: 850  RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
             + EL++ N     I     SLS N  E   K  +       ++        +T LKL  
Sbjct: 460  NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 516

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP +I ++ +L SL  S+N ++ LP  A +    LR L  S+N IS++ +  +  
Sbjct: 517  NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 573

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            L   ++ LH++ NK+  +P ++     L +L++  N  + S P ++G+LS++  L L
Sbjct: 574  LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 629



 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%)

Query: 683  FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737
            +S + + +   ++ IPD   D  F      Q D L S+   G FL +   N +       
Sbjct: 219  YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 277

Query: 738  DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797
            +   ++   ++ R++           +LH    +  P  +  ++   +LDV + ++ P  
Sbjct: 278  EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 327

Query: 798  VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833
             +   +   T L++ +L +          SF+ ++L       TDV E          L 
Sbjct: 328  KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 387

Query: 834  QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887
            +L L      E NK+ G+ S   L+ LKIL++ K++++ +  N  +  P +       + 
Sbjct: 388  ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 446

Query: 888  --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943
              L  +  L   M +  L+L   +   IP AI +L +L+ LD+ SN+I+ +     ++ L
Sbjct: 447  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 506

Query: 944  N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002
              L  L   HN+I  +  S        +E L+ S+NKL+ +P  +  L+ L  LDVSYN 
Sbjct: 507  KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 563

Query: 1003 ELRSFPNEMGKLSKIWDL 1020
             +   P E+G L  +  L
Sbjct: 564  NISMIPIEIGLLQNLQHL 581



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%)

Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779
           S L K  SN   V       V+      L   ++   + ++  L+L + +    P  +  
Sbjct: 421 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 480

Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839
           +S +  LD+  N+I     +        L    L +N++  +P ++T V + LE L    
Sbjct: 481 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 539

Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896
           NK+  +  +   L++L+ L++S N+IS +      L+    +     +++ L    F   
Sbjct: 540 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 599

Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935
            +  L L QN  + +PE +  L  L  L++  N +  LP
Sbjct: 600 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 638



>gi|40788306|dbj|BAA31598.2|   KIAA0623 protein [Homo sapiens]
          Length = 1100

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 52/131 (39%), Positives = 70/131 (53%), Gaps = 13/131 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVME  + G L   LQ        T+  R+ LH +A  +R LHS  II+RDLKP N+LL 
Sbjct: 147  LVMEYCNGGDLADYLQAKGTLSEDTI--RVFLHQIAAAMRILHSKGIIHRDLKPQNILL- 203

Query: 1642 TLYPN------AAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADV 1694
              Y N      + I  KIAD+G A+Y    M   T  G+P + APEV      Y+ +AD+
Sbjct: 204  -SYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQ-HYDAKADL 261

Query: 1695 YSFGLLLYDIL 1705
            +S G ++Y  L
Sbjct: 262  WSIGTVIYQCL 272



>gi|23199985|ref|NP_055498.2|   unc-51-like kinase 2 [Homo sapiens]
          Length = 1036

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 52/131 (39%), Positives = 70/131 (53%), Gaps = 13/131 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVME  + G L   LQ        T+  R+ LH +A  +R LHS  II+RDLKP N+LL 
Sbjct: 83   LVMEYCNGGDLADYLQAKGTLSEDTI--RVFLHQIAAAMRILHSKGIIHRDLKPQNILL- 139

Query: 1642 TLYPN------AAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAPEVARGNVIYNQQADV 1694
              Y N      + I  KIAD+G A+Y    M   T  G+P + APEV      Y+ +AD+
Sbjct: 140  -SYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMSQ-HYDAKADL 197

Query: 1695 YSFGLLLYDIL 1705
            +S G ++Y  L
Sbjct: 198  WSIGTVIYQCL 208



>gi|4758700|ref|NP_004626.1|   mitogen-activated protein kinase-activated protein kinase 3 [Homo
            sapiens]
 gi|14714545|gb|AAH10407.1|   Mitogen-activated protein kinase-activated protein kinase 3 [Homo
            sapiens]
 gi|12804503|gb|AAH01662.1|   Mitogen-activated protein kinase-activated protein kinase 3 [Homo
            sapiens]
 gi|14043206|gb|AAH07591.1|   Mitogen-activated protein kinase-activated protein kinase 3 [Homo
            sapiens]
 gi|7434272|pir||JC6094   MAPK-activated protein kinase (EC 2.7.1.-) 3 - human
 gi|1209018|gb|AAD09136.1|   MAPKAP kinase [Homo sapiens]
 gi|1256005|gb|AAC50428.1|   mitogen activated protein kinase activated protein kinase-3
 gi|1589557|prf||2211336A   MAP kinase-activated protein kinase 3
 gi|1588508|prf||2208434A   3pK protein
          Length = 382

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 60/208 (28%), Positives = 97/208 (46%), Gaps = 39/208 (18%)

Query: 1577 GIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP 1635
            G R  +++ME    G L  R+ ++   + T      I   +   +++LHS  I +RD+KP
Sbjct: 110  GKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKP 169

Query: 1636 HNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVY 1695
             N LL+T     A++ K+ D+G A+   +  ++T   TP + APEV  G   Y++  D++
Sbjct: 170  EN-LLYTSKEKDAVL-KLTDFGFAKETTQNALQTPCYTPYYVAPEVL-GPEKYDKSCDMW 226

Query: 1696 SFGLLLYDIL--------TTGGRIVEGLK---------FPN-EFDELEIQGKLPDPVKEY 1737
            S G+++Y +L         TG  I  G+K         FPN E+ E+    K        
Sbjct: 227  SLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAK-------- 278

Query: 1738 GCAPWPMVEKLIKQCLKENPQERPTSAQ 1765
                     +LI+  LK +P ER T  Q
Sbjct: 279  ---------QLIRLLLKTDPTERLTITQ 297



>gi|52545731|emb|CAH56273.1|   hypothetical protein [Homo sapiens]
          Length = 805

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%)

Query: 741  LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794
            L  C   +++ + S     L  L +        P+  YLLK    +  I NL+   N + 
Sbjct: 467  LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 525

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849
              + L+   +   LK  ++  N L+ VP N+TDV   L +L++  +G K+   + +   +
Sbjct: 526  --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 582

Query: 850  RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
             + EL++ N     I     SLS N  E   K  +       ++        +T LKL  
Sbjct: 583  NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 639

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP +I ++ +L SL  S+N ++ LP  A +    LR L  S+N IS++ +  +  
Sbjct: 640  NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 696

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            L   ++ LH++ NK+  +P ++     L +L++  N  + S P ++G+LS++  L L
Sbjct: 697  LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 752



 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%)

Query: 683  FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737
            +S + + +   ++ IPD   D  F      Q D L S+   G FL +   N +       
Sbjct: 342  YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 400

Query: 738  DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797
            +   ++   ++ R++           +LH    +  P  +  ++   +LDV + ++ P  
Sbjct: 401  EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 450

Query: 798  VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833
             +   +   T L++ +L +          SF+ ++L       TDV E          L 
Sbjct: 451  KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 510

Query: 834  QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887
            +L L      E NK+ G+ S   L+ LKIL++ K++++ +  N  +  P +       + 
Sbjct: 511  ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 569

Query: 888  --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943
              L  +  L   M +  L+L   +   IP AI +L +L+ LD+ SN+I+ +     ++ L
Sbjct: 570  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 629

Query: 944  N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002
              L  L   HN+I  +  S        +E L+ S+NKL+ +P  +  L+ L  LDVSYN 
Sbjct: 630  KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 686

Query: 1003 ELRSFPNEMGKLSKIWDL 1020
             +   P E+G L  +  L
Sbjct: 687  NISMIPIEIGLLQNLQHL 704



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%)

Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779
           S L K  SN   V       V+      L   ++   + ++  L+L + +    P  +  
Sbjct: 544 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 603

Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839
           +S +  LD+  N+I     +        L    L +N++  +P ++T V + LE L    
Sbjct: 604 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 662

Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896
           NK+  +  +   L++L+ L++S N+IS +      L+    +     +++ L    F   
Sbjct: 663 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 722

Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935
            +  L L QN  + +PE +  L  L  L++  N +  LP
Sbjct: 723 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 761



>gi|52545685|emb|CAH56285.1|   hypothetical protein [Homo sapiens]
          Length = 819

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 79/297 (26%), Positives = 140/297 (47%), Gaps = 26/297 (8%)

Query: 741  LQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPS--YLLK----MSCIANLDVSRNDIG 794
            L  C   +++ + S     L  L +        P+  YLLK    +  I NL+   N + 
Sbjct: 481  LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM- 539

Query: 795  PSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPL 849
              + L+   +   LK  ++  N L+ VP N+TDV   L +L++  +G K+   + +   +
Sbjct: 540  --IGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMM 596

Query: 850  RLKELKILNLSKNHIS----SLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQ 905
             + EL++ N     I     SLS N  E   K  +       ++        +T LKL  
Sbjct: 597  NVAELELQNCELERIPHAIFSLS-NLQELDLKSNNIRTIEEIISFQHL--KRLTCLKLWH 653

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP +I ++ +L SL  S+N ++ LP  A +    LR L  S+N IS++ +  +  
Sbjct: 654  NKIVTIPPSITHVKNLESLYFSNNKLESLP-VAVFSLQKLRCLDVSYNNISMIPI--EIG 710

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            L   ++ LH++ NK+  +P ++     L +L++  N  + S P ++G+LS++  L L
Sbjct: 711  LLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNC-ITSLPEKVGQLSQLTQLEL 766



 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 91/378 (24%), Positives = 164/378 (43%), Gaps = 55/378 (14%)

Query: 683  FSEDVLSKFDEWTFIPDSSMDSVFA-----QSDDLDSEGSEGSFLVKKKSNSISVGEFYR 737
            +S + + +   ++ IPD   D  F      Q D L S+   G FL +   N +       
Sbjct: 356  YSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRF-GVFLSEVSENKLREISLNH 414

Query: 738  DAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSV 797
            +   ++   ++ R++           +LH    +  P  +  ++   +LDV + ++ P  
Sbjct: 415  EWTFEKLRQHISRNAQDKQ-------ELHLFMLSGVPDAVFDLT---DLDVLKLELIPEA 464

Query: 798  VLDPTVKCPT-LKQFNLSY-------NQLSFVPENL-------TDVVE---------KLE 833
             +   +   T L++ +L +          SF+ ++L       TDV E          L 
Sbjct: 465  KIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLR 524

Query: 834  QLIL------EGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 887
            +L L      E NK+ G+ S   L+ LKIL++ K++++ +  N  +  P +       + 
Sbjct: 525  ELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIHNDG 583

Query: 888  --LAAMPFLPPSMTI--LKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSL 943
              L  +  L   M +  L+L   +   IP AI +L +L+ LD+ SN+I+ +     ++ L
Sbjct: 584  TKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHL 643

Query: 944  N-LRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNL 1002
              L  L   HN+I  +  S        +E L+ S+NKL+ +P  +  L+ L  LDVSYN 
Sbjct: 644  KRLTCLKLWHNKIVTIPPSITHV--KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN- 700

Query: 1003 ELRSFPNEMGKLSKIWDL 1020
             +   P E+G L  +  L
Sbjct: 701  NISMIPIEIGLLQNLQHL 718



 Score = 54.7 bits (130), Expect = 2e-06
 Identities = 49/219 (22%), Positives = 93/219 (42%), Gaps = 4/219 (1%)

Query: 720 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLK 779
           S L K  SN   V       V+      L   ++   + ++  L+L + +    P  +  
Sbjct: 558 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 617

Query: 780 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEG 839
           +S +  LD+  N+I     +        L    L +N++  +P ++T V + LE L    
Sbjct: 618 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHV-KNLESLYFSN 676

Query: 840 NKISGI-CSPLRLKELKILNLSKNHISSL--SENFLEACPKVESFSARMNFLAAMPFLPP 896
           NK+  +  +   L++L+ L++S N+IS +      L+    +     +++ L    F   
Sbjct: 677 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 736

Query: 897 SMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 935
            +  L L QN  + +PE +  L  L  L++  N +  LP
Sbjct: 737 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 775



>gi|9247171|gb|AAB33113.2|   tyrosine kinase p59fyn(T) [Homo sapiens]
          Length = 534

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 64/234 (27%), Positives = 108/234 (46%), Gaps = 31/234 (13%)

Query: 1539 TIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLL 1597
            T+    ++P+  L +      L +D+L       + +    P  +V E  +KGSL D L 
Sbjct: 297  TLKPGTMSPESFLEEAQIMKKLKHDKL----VQLYAVVSEEPIYIVTEYMNKGSLLDFLK 352

Query: 1598 QQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYG 1657
              +  +L       +A  VA G+ Y+     I+RDL+  N+L+        +I KIAD+G
Sbjct: 353  DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILV-----GNGLICKIADFG 407

Query: 1658 IA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ---QADVYSFGLLLYDILTTG 1708
            +A      +Y  R G K       F     A    +Y +   ++DV+SFG+LL +++T G
Sbjct: 408  LARLIEDNEYTARQGAK-------FPIKWTAPERALYGRFTIKSDVWSFGILLTELVTKG 460

Query: 1709 GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
                 G+      +++E   ++P P       P  + E +I  C K++P+ERPT
Sbjct: 461  RVPYPGMNNREVLEQVERGYRMPCPQD----CPISLHELMI-HCWKKDPEERPT 509



>gi|5688866|dbj|BAA82709.1|   Aik2 [Homo sapiens]
          Length = 343

 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 55/185 (29%), Positives = 86/185 (46%), Gaps = 17/185 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            L++E A +G L + LQ+   +        I   +AD L Y H   +I+RD+KP N+LL  
Sbjct: 152  LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 208

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                     KIAD+G + +   +  KT  GT  +  PE+  G  I N++ D++  G+L Y
Sbjct: 209  ---GLKGELKIADFGWSVHATSLRRKTMCGTLDYLPPEMIEGR-IDNEKVDLWCIGVLCY 264

Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            ++L   G   E       +  + ++  K P  V           + LI + L+ NP ER 
Sbjct: 265  ELLV--GNPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSERL 315

Query: 1762 TSAQV 1766
              AQV
Sbjct: 316  PLAQV 320



>gi|29029632|ref|NP_004295.2|   anaplastic lymphoma kinase Ki-1 [Homo sapiens]
          Length = 1620

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 1191 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 1250

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 1251 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 1308

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 1309 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 1363

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 1364 QCWQHQPEDRPNFAIILE 1381



>gi|14042212|dbj|BAB55153.1|   unnamed protein product [Homo sapiens]
          Length = 474

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814
            ++L  L +        P ++  +  +  L ++ N   +    +V+D   +   LK   L 
Sbjct: 157  ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 216

Query: 815  YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865
             N LS +P+ +TDV   L++L +  EG K+   + +     L EL+++      I     
Sbjct: 217  SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 275

Query: 866  --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905
                     L +N L+   ++ SF             N +A +P    ++T L+   L++
Sbjct: 276  SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 335

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP  +     LR LD+S N++ +LP        NL+ L  + N+I  L    + +
Sbjct: 336  NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 392

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013
               ++  LHL +N L+ +P  +G L NLT +++  N  L   P E+G+
Sbjct: 393  QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 439



 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%)

Query: 748  LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807
            L +    LT  +   L+LH    +  P  +  +     L+V + ++ P V + P++   T
Sbjct: 77   LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 133

Query: 808  -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843
             LK+  L +         L+F+ ENL       TD+ E          LE+L L GN  +
Sbjct: 134  GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 193

Query: 844  G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889
                  +   LR LK LK+L L K+++S L +   +    ++  S          +N L 
Sbjct: 194  ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 252

Query: 890  AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946
             M     ++T L+L +     IP +I +L +L+ +D+  N+   I+ +    H   L   
Sbjct: 253  KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 308

Query: 947  ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987
            +L ++H      QI  L   E+ YL  +++EK             L LSHN L  +P +I
Sbjct: 309  KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 368

Query: 988  GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            G L+NL +L ++ N  + + P E+ +  K+  L L
Sbjct: 369  GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 402



>gi|13186236|ref|NP_075594.1|   fibroblast growth factor receptor 1 isoform 4 precursor [Homo
            sapiens]
 gi|60552859|gb|AAH91494.1|   FGFR1 protein [Homo sapiens]
 gi|31387|emb|CAA40404.1|   Fibroblast Growth Factor Receptor, 2 Ig-Domain Form [Homo sapiens]
          Length = 731

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 465  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 524

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 525  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 579

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 580  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 635

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 636  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 670



>gi|37181692|gb|AAQ88653.1|   RQTI221 [Homo sapiens]
 gi|39930379|ref|NP_062540.1|   leucine rich repeat containing 8 [Homo sapiens]
          Length = 546

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814
            ++L  L +        P ++  +  +  L ++ N   +    +V+D   +   LK   L 
Sbjct: 229  ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 288

Query: 815  YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865
             N LS +P+ +TDV   L++L +  EG K+   + +     L EL+++      I     
Sbjct: 289  SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 347

Query: 866  --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905
                     L +N L+   ++ SF             N +A +P    ++T L+   L++
Sbjct: 348  SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 407

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP  +     LR LD+S N++ +LP        NL+ L  + N+I  L    + +
Sbjct: 408  NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 464

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013
               ++  LHL +N L+ +P  +G L NLT +++  N  L   P E+G+
Sbjct: 465  QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 511



 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%)

Query: 748  LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807
            L +    LT  +   L+LH    +  P  +  +     L+V + ++ P V + P++   T
Sbjct: 149  LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 205

Query: 808  -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843
             LK+  L +         L+F+ ENL       TD+ E          LE+L L GN  +
Sbjct: 206  GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 265

Query: 844  G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889
                  +   LR LK LK+L L K+++S L +   +    ++  S          +N L 
Sbjct: 266  ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 324

Query: 890  AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946
             M     ++T L+L +     IP +I +L +L+ +D+  N+   I+ +    H   L   
Sbjct: 325  KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 380

Query: 947  ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987
            +L ++H      QI  L   E+ YL  +++EK             L LSHN L  +P +I
Sbjct: 381  KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 440

Query: 988  GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            G L+NL +L ++ N  + + P E+ +  K+  L L
Sbjct: 441  GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 474



>gi|11276087|ref|NP_000595.1|   fibroblast growth factor receptor 1 isoform 1 precursor [Homo
            sapiens]
 gi|35110|emb|CAA47375.1|   fibroblast growth factor receptor [Homo sapiens]
 gi|31393|emb|CAA40403.1|   Fibroblast Growth Factor Receptor, 3-Ig Domain+2 AA insert [Homo
            sapiens]
 gi|476559|pir||TVHUFG   fibroblast growth factor receptor 1 precursor - human
 gi|45934432|gb|AAS79322.1|   fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2,
            Pfeiffer syndrome) [Homo sapiens]
 gi|120046|sp|P11362|FGFR1_HUMAN   Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R)
            (Fms-like tyrosine kinase-2) (c-fgr)
 gi|31378|emb|CAA37015.1|   unnamed protein product [Homo sapiens]
          Length = 822

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 556  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 615

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 616  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 671  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 726

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 727  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 761



>gi|31368|emb|CAA36101.1|   unnamed protein product [Homo sapiens]
          Length = 822

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 556  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 615

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 616  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 671  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 726

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 727  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 761



>gi|179415|gb|AAA75007.1|   basic fibroblast growth factor receptor protein
          Length = 731

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 465  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 524

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 525  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 579

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 580  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 635

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 636  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 670



>gi|13186251|ref|NP_056934.2|   fibroblast growth factor receptor 1 isoform 2 precursor [Homo
            sapiens]
 gi|31391|emb|CAA40402.1|   Fibroblast Growth Factor Receptor, 3 Ig-Domain Form [Homo sapiens]
 gi|182561|gb|AAA35840.1|   fibroblast growth factor receptor
          Length = 820

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 554  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 614  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 669  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 725  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759



>gi|182534|gb|AAA35837.1|   fibroblast growth factor receptor (FGFr) transmembrane form
          Length = 731

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 465  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 524

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 525  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 579

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 580  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 635

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 636  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 670



>gi|13186234|ref|NP_075593.1|   fibroblast growth factor receptor 1 isoform 3 precursor [Homo
            sapiens]
 gi|31389|emb|CAA40401.1|   Fibroblast Growth Factor Receptor, 2-Ig Domain+2 AA insert [Homo
            sapiens]
 gi|182532|gb|AAA35836.1|   fibroblast growth factor receptor (FGFr) transmembrane form
          Length = 733

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 467  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 526

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 527  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 581

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 582  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 637

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 638  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 672



>gi|37181710|gb|AAQ88662.1|   SAPS287 [Homo sapiens]
          Length = 1059

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 63/230 (27%), Positives = 108/230 (46%), Gaps = 42/230 (18%)

Query: 807  TLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE---LKILNLSKNH 863
            +L++  L+ N+L  +P NL  V   +  L L GN+I  I  P  LKE   L+ L+LS N+
Sbjct: 39   SLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEIL-PEHLKEFQSLETLDLSSNN 96

Query: 864  ISSLSENFLEACPKVESFSARMNFLAAMP-----FLPPSMTILKLSQNKFSCIPEAILNL 918
            IS L   F     +++      N + +M       L  ++ +LKL++N+ S IP  +  L
Sbjct: 97   ISELQTAF--PALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKL 154

Query: 919  PHLRSLDMSSNDIQYLPG------------------------PAHWKSLNLRELLFSHNQ 954
            P L+ L+++ N I+ + G                         A W   N+  L   HN 
Sbjct: 155  PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 214

Query: 955  ISILDLSEKAYLWS--RVEKLHLSHNKLKEIPPEI-GCLENLTSLDVSYN 1001
            ++ +    K +L+    +++LHLS N +  I P+     + L+ LD+++N
Sbjct: 215  LTEI---TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFN 261



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 67/286 (23%), Positives = 125/286 (43%), Gaps = 30/286 (10%)

Query: 759  SLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL 818
            +L  L L+ N+ ++ P  + K+  + +L+++RN I  +V          LK   +  N +
Sbjct: 133  TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKI-KNVDGLTFQGLGALKSLKMQRNGV 191

Query: 819  SFVPENLTDVVEKLEQLILEGNKISGICSP--LRLKELKILNLSKNHISSLSENFLEACP 876
            + + +     +  +E L L+ N ++ I       L  L+ L+LS+N I+ +S +  E C 
Sbjct: 192  TKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQ 251

Query: 877  KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPG 936
            K+       N L+            +L  + F       L L  L +L + +N + Y+  
Sbjct: 252  KLSELDLTFNHLS------------RLDDSSF-------LGLSLLNTLHIGNNRVSYIAD 292

Query: 937  PAHWKSLNLRELLFSHNQIS--ILDLSEKAYLWSRVEKLHLSHNKLKEIPPE-IGCLENL 993
             A     +L+ L   +N+IS  I D++       ++ +L L  N+++ I  +    L+ L
Sbjct: 293  CAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDAL 352

Query: 994  TSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAK 1039
              LD+S N  +    N   ++ K     L +LHLN       C+ K
Sbjct: 353  EHLDLSDNAIMSLQGNAFSQMKK-----LQQLHLNTSSLLCDCQLK 393



>gi|30410930|gb|AAH51322.1|   LRRC8 protein [Homo sapiens]
 gi|27462054|gb|AAN18279.1|   leucine-rich repeat-containing 8 [Homo sapiens]
 gi|55859580|emb|CAI10839.1|   leucine rich repeat containing 8 [Homo sapiens]
 gi|37537912|sp|Q8IWT6|LRR8_HUMAN   Leucine-rich repeat-containing protein 8 precursor
          Length = 810

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814
            ++L  L +        P ++  +  +  L ++ N   +    +V+D   +   LK   L 
Sbjct: 493  ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 552

Query: 815  YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865
             N LS +P+ +TDV   L++L +  EG K+   + +     L EL+++      I     
Sbjct: 553  SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 611

Query: 866  --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905
                     L +N L+   ++ SF             N +A +P    ++T L+   L++
Sbjct: 612  SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 671

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP  +     LR LD+S N++ +LP        NL+ L  + N+I  L    + +
Sbjct: 672  NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 728

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013
               ++  LHL +N L+ +P  +G L NLT +++  N  L   P E+G+
Sbjct: 729  QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 775



 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%)

Query: 748  LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807
            L +    LT  +   L+LH    +  P  +  +     L+V + ++ P V + P++   T
Sbjct: 413  LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 469

Query: 808  -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843
             LK+  L +         L+F+ ENL       TD+ E          LE+L L GN  +
Sbjct: 470  GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 529

Query: 844  G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889
                  +   LR LK LK+L L K+++S L +   +    ++  S          +N L 
Sbjct: 530  ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 588

Query: 890  AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946
             M     ++T L+L +     IP +I +L +L+ +D+  N+   I+ +    H   L   
Sbjct: 589  KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644

Query: 947  ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987
            +L ++H      QI  L   E+ YL  +++EK             L LSHN L  +P +I
Sbjct: 645  KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 704

Query: 988  GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            G L+NL +L ++ N  + + P E+ +  K+  L L
Sbjct: 705  GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 738



>gi|38197155|gb|AAH00442.2|   AURKB protein [Homo sapiens]
          Length = 364

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 54/185 (29%), Positives = 87/185 (47%), Gaps = 16/185 (8%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            L++E A +G L + LQ+   +        I   +AD L Y H   +I+RD+KP N+LL  
Sbjct: 172  LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 228

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                     KIAD+G + +   +  KT  GT  +  PE+  G  ++N++ D++  G+L Y
Sbjct: 229  ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 284

Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            ++L  G    E       +  + ++  K P  V           + LI + L+ NP ER 
Sbjct: 285  ELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSERL 336

Query: 1762 TSAQV 1766
              AQV
Sbjct: 337  PLAQV 341



>gi|21955340|gb|AAH15035.1|   FGFR1 protein [Homo sapiens]
          Length = 820

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 554  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 614  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 669  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 725  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759



>gi|17939640|gb|AAH19334.1|   Serine/threonine protein kinase 11 [Homo sapiens]
 gi|14124918|gb|AAH07981.1|   Serine/threonine protein kinase 11 [Homo sapiens]
 gi|4507271|ref|NP_000446.1|   serine/threonine protein kinase 11 [Homo sapiens]
 gi|2754827|gb|AAC39527.1|   serine threonine kinase 11 [Homo sapiens]
 gi|3063585|gb|AAC15742.1|   Peutz-Jeghers syndrome protein [Homo sapiens]
 gi|2791676|gb|AAB97833.1|   serine threonine kinase 11 [Homo sapiens]
 gi|1480861|gb|AAB05809.1|   serine/threonine protein kinase [Homo sapiens]
 gi|3024670|sp|Q15831|STK11_HUMAN   Serine/threonine-protein kinase 11 (Serine/threonine-protein kinase
            LKB1)
          Length = 433

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/189 (30%), Positives = 90/189 (47%), Gaps = 17/189 (8%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME    G  + L    +        H     + DGL YLHS  I+++D+KP N+LL T
Sbjct: 127  MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTT 186

Query: 1643 LYPNAAIIAKIADYGIAQ----YCCRMGIKTSEGTPGFRAPEVARG-NVIYNQQADVYSF 1697
                     KI+D G+A+    +      +TS+G+P F+ PE+A G +     + D++S 
Sbjct: 187  -----GGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSA 241

Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757
            G+ LY+I TTG    EG      F+ +  +G    P     C   P +  L+K  L+  P
Sbjct: 242  GVTLYNI-TTGLYPFEGDNIYKLFENIG-KGSYAIP---GDCG--PPLSDLLKGMLEYEP 294

Query: 1758 QERPTSAQV 1766
             +R +  Q+
Sbjct: 295  AKRFSIRQI 303



>gi|54695938|gb|AAV38341.1|   serine/threonine kinase 12 [Homo sapiens]
 gi|51593788|gb|AAH80581.1|   Aurora kinase B [Homo sapiens]
 gi|4759178|ref|NP_004208.1|   aurora kinase B [Homo sapiens]
 gi|2979630|gb|AAC12709.1|   aurora-related kinase 2 [Homo sapiens]
 gi|27805737|sp|Q96GD4|AURKB_HUMAN   Serine/threonine-protein kinase 12 (Aurora- and Ipl1-like
            midbody-associated protein 1) (AIM-1)
            (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2)
            (STK-1) (Aurora-B)
 gi|3402293|dbj|BAA32136.1|   aurora and IPL1-like midbody-associated protein kinase-1 [Homo
            sapiens]
          Length = 344

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 54/185 (29%), Positives = 87/185 (47%), Gaps = 16/185 (8%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            L++E A +G L + LQ+   +        I   +AD L Y H   +I+RD+KP N+LL  
Sbjct: 152  LILEYAPRGELYKELQKS-CTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLL-- 208

Query: 1643 LYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                     KIAD+G + +   +  KT  GT  +  PE+  G  ++N++ D++  G+L Y
Sbjct: 209  ---GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVLCY 264

Query: 1703 DILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 1761
            ++L  G    E       +  + ++  K P  V           + LI + L+ NP ER 
Sbjct: 265  ELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSERL 316

Query: 1762 TSAQV 1766
              AQV
Sbjct: 317  PLAQV 321



>gi|20269390|gb|AAM17922.1|   TRK-fused gene/anaplastic large cell lymphoma kinase extra long form
            [Homo sapiens]
          Length = 803

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 374  PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 433

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 434  AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 491

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 492  KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 546

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 547  QCWQHQPEDRPNFAIILE 564



>gi|22450878|gb|AAH18128.1|   Fibroblast growth factor receptor 1, isoform 2 precursor [Homo
            sapiens]
          Length = 820

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 554  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 614  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 669  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 725  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759



>gi|609342|gb|AAA58698.1|   nucleophosmin-anaplastic lymphoma kinase fusion protein
          Length = 680

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 251  PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 310

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 311  AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 368

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 369  KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 423

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 424  QCWQHQPEDRPNFAIILE 441



>gi|2454168|gb|AAB71619.1|   anaplastic lymphoma kinase [Homo sapiens]
 gi|20137251|sp|Q9UM73|ALK_HUMAN   ALK tyrosine kinase receptor precursor (Anaplastic lymphoma kinase)
            (CD246 antigen)
          Length = 1620

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 1191 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 1250

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 1251 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 1308

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 1309 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 1363

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 1364 QCWQHQPEDRPNFAIILE 1381



>gi|182530|gb|AAA35835.1|   FGF receptor-1 precursor [Homo sapiens]
          Length = 820

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 554  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 613

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 614  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 668

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 669  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 724

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 725  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 759



>gi|7229261|gb|AAF42734.1|   TRK-fused gene-anaplastic lymphoma kinase fusion protein [Homo
            sapiens]
          Length = 701

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 272  PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 331

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 332  AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 389

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 390  KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 444

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 445  QCWQHQPEDRPNFAIILE 462



>gi|6739535|gb|AAF27292.1|   TRK-fused gene/anaplastic lymphoma kinase (Ki-1) fusion protein long
            form [Homo sapiens]
          Length = 756

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 327  PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 386

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 387  AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 444

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 445  KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 499

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 500  QCWQHQPEDRPNFAIILE 517



>gi|6467479|gb|AAF13156.1|   double stranded RNA activated protein kinase [Homo sapiens]
          Length = 551

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 19/188 (10%)

Query: 1585 MELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643
            ME   KG+L++ +++ +   L + L   +   +  G+ Y+HS  +I+RDLKP N+ L   
Sbjct: 366  MEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT 425

Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKT-SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                    KI D+G+       G +T S+GT  + +PE    +  Y ++ D+Y+ GL+L 
Sbjct: 426  KQ-----VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILA 479

Query: 1703 DILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
            ++L       E  KF   F +L   G + D   +         E L+++ L + P++RP 
Sbjct: 480  ELLHVCDTAFETSKF---FTDLR-DGIISDIXDK-------KEETLLQKLLSKXPEDRPN 528

Query: 1763 SAQVFDIL 1770
            ++++   L
Sbjct: 529  TSEILRTL 536



>gi|1848244|gb|AAC51104.1|   anaplastic lymphoma kinase receptor
          Length = 1620

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 1191 PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 1250

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 1251 AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 1308

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 1309 KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 1363

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 1364 QCWQHQPEDRPNFAIILE 1381



>gi|10441887|gb|AAG17221.1|   unknown [Homo sapiens]
          Length = 433

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/189 (30%), Positives = 90/189 (47%), Gaps = 17/189 (8%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFT 1642
            +VME    G  + L    +        H     + DGL YLHS  I+++D+KP N+LL T
Sbjct: 127  MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTT 186

Query: 1643 LYPNAAIIAKIADYGIAQ----YCCRMGIKTSEGTPGFRAPEVARG-NVIYNQQADVYSF 1697
                     KI+D G+A+    +      +TS+G+P F+ PE+A G +     + D++S 
Sbjct: 187  -----GGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSA 241

Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757
            G+ LY+I TTG    EG      F+ +  +G    P     C   P +  L+K  L+  P
Sbjct: 242  GVTLYNI-TTGLYPFEGDNIYKLFENIG-KGSYAIP---GDCG--PPLSDLLKGMLEYEP 294

Query: 1758 QERPTSAQV 1766
             +R +  Q+
Sbjct: 295  AKRFSIRQI 303



>gi|38492661|pdb|1OL7|A   Chain A, Structure Of Human Aurora-A 122-403 Phosphorylated On
            Thr287, Thr288
 gi|38492658|pdb|1OL5|A   Chain A, Structure Of Aurora-A 122-403, Phosphorylated On Thr287,
            Thr288 And Bound To Tpx2 1-43
          Length = 282

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 55/190 (28%), Positives = 94/190 (49%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 87   LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 142

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIAD+G + +          GT  +  PE+  G  +++++ D++S G+
Sbjct: 143  L-----GSAGELKIADFGWSVHAPSSRRXXLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 196

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 197  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 248

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 249  QRPMLREVLE 258



>gi|38492660|pdb|1OL6|A   Chain A, Structure Of Unphosphorylated D274n Mutant Of Aurora-A
          Length = 282

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 55/190 (28%), Positives = 95/190 (50%), Gaps = 22/190 (11%)

Query: 1583 LVMELASKGSLDRLLQQDKASLTRTLQHRIALHV---ADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A  G++ R LQ+    L++  + R A ++   A+ L Y HS  +I+RD+KP N+L
Sbjct: 87   LILEYAPLGTVYRELQK----LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLL 142

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L      +A   KIA++G + +       T  GT  +  PE+  G  +++++ D++S G+
Sbjct: 143  L-----GSAGELKIANFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSLGV 196

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y+ L  G    E   +   +  +  ++   PD V E           LI + LK NP 
Sbjct: 197  LCYEFL-VGKPPFEANTYQETYKRISRVEFTFPDFVTE-------GARDLISRLLKHNPS 248

Query: 1759 ERPTSAQVFD 1768
            +RP   +V +
Sbjct: 249  QRPMLREVLE 258



>gi|6137569|pdb|2FGI|B   Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of Fgf
            Receptor 1 In Complex With Inhibitor Pd173074
 gi|6137568|pdb|2FGI|A   Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of Fgf
            Receptor 1 In Complex With Inhibitor Pd173074
 gi|2392335|pdb|1FGK|B   Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of
            Fibroblast Growth Factor Receptor 1
 gi|2392334|pdb|1FGK|A   Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of
            Fibroblast Growth Factor Receptor 1
 gi|3114386|pdb|1FGI|B   Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of
            Fibroblast Growth Factor Receptor 1 In Complex With
            Su5402 Inhibitor
 gi|3114385|pdb|1FGI|A   Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of
            Fibroblast Growth Factor Receptor 1 In Complex With
            Su5402 Inhibitor
 gi|3114535|pdb|1AGW|B   Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of
            Fibroblast Growth Factor Receptor 1 In Complex With
            Su4984 Inhibitor
 gi|3114534|pdb|1AGW|A   Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of
            Fibroblast Growth Factor Receptor 1 In Complex With
            Su4984 Inhibitor
          Length = 310

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 101  PLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 160

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 161  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 215

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 216  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 271

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 272  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 306



>gi|1483131|dbj|BAA08343.1|   p80 protein [Homo sapiens]
          Length = 680

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 57/198 (28%), Positives = 90/198 (45%), Gaps = 16/198 (8%)

Query: 1580 PRMLVMELASKGSLDRLLQQDK------ASLTRTLQHRIALHVADGLRYLHSAMIIYRDL 1633
            PR +++EL + G L   L++ +      +SL       +A  +A G +YL     I+RD+
Sbjct: 251  PRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDI 310

Query: 1634 KPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT---PGFRAPEVARGNVIYNQ 1690
               N LL    P    +AKI D+G+A+   R       G    P    P  A    I+  
Sbjct: 311  AARNCLLTC--PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTS 368

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            + D +SFG+LL++I +  G +    K   E  E    G   DP K     P P V +++ 
Sbjct: 369  KTDTWSFGVLLWEIFSL-GYMPYPSKSNQEVLEFVTSGGRMDPPKN---CPGP-VYRIMT 423

Query: 1751 QCLKENPQERPTSAQVFD 1768
            QC +  P++RP  A + +
Sbjct: 424  QCWQHQPEDRPNFAIILE 441



>gi|7243272|dbj|BAA92675.1|   KIAA1437 protein [Homo sapiens]
          Length = 811

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 37/288 (12%)

Query: 758  KSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN---DIGPSVVLDPTVKCPTLKQFNLS 814
            ++L  L +        P ++  +  +  L ++ N   +    +V+D   +   LK   L 
Sbjct: 494  ENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLK 553

Query: 815  YNQLSFVPENLTDVVEKLEQLIL--EGNKI---SGICSPLRLKELKILNLSKNHIS---- 865
             N LS +P+ +TDV   L++L +  EG K+   + +     L EL+++      I     
Sbjct: 554  SN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIF 612

Query: 866  --------SLSENFLEACPKVESFSAR---------MNFLAAMPFLPPSMTILK---LSQ 905
                     L +N L+   ++ SF             N +A +P    ++T L+   L++
Sbjct: 613  SLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNR 672

Query: 906  NKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAY 965
            NK   IP  +     LR LD+S N++ +LP        NL+ L  + N+I  L    + +
Sbjct: 673  NKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQ-NLQNLAITANRIETLP--PELF 729

Query: 966  LWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGK 1013
               ++  LHL +N L+ +P  +G L NLT +++  N  L   P E+G+
Sbjct: 730  QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGN-RLECLPVELGE 776



 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 87/335 (25%), Positives = 148/335 (44%), Gaps = 69/335 (20%)

Query: 748  LQRHSNSLTLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPT 807
            L +    LT  +   L+LH    +  P  +  +     L+V + ++ P V + P++   T
Sbjct: 414  LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDL---VELEVLKLELIPDVTIPPSIAQLT 470

Query: 808  -LKQFNLSYNQ-------LSFVPENL-------TDVVE---------KLEQLILEGNKIS 843
             LK+  L +         L+F+ ENL       TD+ E          LE+L L GN  +
Sbjct: 471  GLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSA 530

Query: 844  G-----ICSPLR-LKELKILNLSKNHISSLSENFLEACPKVESFSAR--------MNFLA 889
                  +   LR LK LK+L L K+++S L +   +    ++  S          +N L 
Sbjct: 531  ENNRYIVIDGLRELKRLKVLRL-KSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLK 589

Query: 890  AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSND---IQYLPGPAHWKSLNLR 946
             M     ++T L+L +     IP +I +L +L+ +D+  N+   I+ +    H   L   
Sbjct: 590  KMA----NLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 645

Query: 947  ELLFSHN-----QISILDLSEKAYL-WSRVEK-------------LHLSHNKLKEIPPEI 987
            +L ++H      QI  L   E+ YL  +++EK             L LSHN L  +P +I
Sbjct: 646  KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI 705

Query: 988  GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1022
            G L+NL +L ++ N  + + P E+ +  K+  L L
Sbjct: 706  GLLQNLQNLAITAN-RIETLPPELFQCRKLRALHL 739



>gi|183879|gb|AAA35958.1|   heparin-binding growth factor receptor
          Length = 822

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 556  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 615

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 616  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 670

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 671  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 726

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 727  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 761



>gi|558584|emb|CAA68679.1|   tyrosine kinase [Homo sapiens]
          Length = 622

 Score = 66.2 bits (160), Expect = 7e-10
 Identities = 68/219 (31%), Positives = 102/219 (46%), Gaps = 32/219 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQ---------------QDKASLTRTLQHRIALHVADGLRYLH 1624
            P  +++E ASKG+L   LQ                 +  L+       A  VA G+ YL 
Sbjct: 356  PLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 415

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 416  SKKCIHRDLAARNVLV-----TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPE 470

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + IY  Q+DV+SFG+LL++I T GG    G+     F  L+ +G   D  K   C 
Sbjct: 471  -ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLK-EGHRMD--KPSNCT 526

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 1779
                +  +++ C    P +RPT  Q+ + L+   +V LT
Sbjct: 527  --NELYMMMRDCWHAVPSQRPTFKQLVEDLD--RIVALT 561



>gi|107565|pir||S24066   protein-tyrosine kinase (EC 2.7.1.112), receptor type tie precursor -
            human
          Length = 1138

 Score = 65.9 bits (159), Expect = 9e-10
 Identities = 47/157 (29%), Positives = 83/157 (52%), Gaps = 12/157 (7%)

Query: 1611 RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS 1670
            R A   A+G++YL     I+RDL   NVL+        + +KIAD+G+++    + +K +
Sbjct: 958  RFASDAANGMQYLSEKQFIHRDLAARNVLV-----GENLASKIADFGLSRGE-EVYVKKT 1011

Query: 1671 EGTPGFRAPEVARGNV-IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGK 1729
             G    R   +   N  +Y  ++DV+SFG+LL++I++ GG    G+     +++L    +
Sbjct: 1012 MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQADR 1071

Query: 1730 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQV 1766
            +  P     C     V +L++QC ++ P ERP  AQ+
Sbjct: 1072 MEQP---RNCD--DEVYELMRQCWRDRPYERPPFAQI 1103



>gi|7662320|ref|NP_055628.1|   leucine-rich repeats and immunoglobulin-like domains 2 [Homo sapiens]
 gi|55664387|emb|CAH73254.1|   leucine-rich repeats and immunoglobulin-like domains 2 [Homo sapiens]
 gi|54036167|sp|O94898|LIG2_HUMAN   Leucine-rich repeats and immunoglobulin-like domains protein 2
            precursor (LIG-2)
          Length = 1065

 Score = 65.9 bits (159), Expect = 9e-10
 Identities = 91/366 (24%), Positives = 150/366 (40%), Gaps = 92/366 (25%)

Query: 784  ANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVP------ENLT----------- 826
            A LD S N +    +   +++  TL++  ++YN+L+ +P       N+T           
Sbjct: 78   AILDFSHNRLSNWNI---SLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPE 134

Query: 827  ------DVVEKLEQLILEGNKISGI-CSPLRLKELKILNLSKNHISSLSENFLEACPKVE 879
                       LE L L  N IS I  S     +LK LNLS N I++L     +      
Sbjct: 135  INAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDN----- 189

Query: 880  SFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPH------------------- 920
                          L  S+ ++KL++N+ S IP  I  LPH                   
Sbjct: 190  --------------LSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTF 235

Query: 921  -----LRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS--RVEKL 973
                 LRSL M  N I  L   A +   N+ EL   HN ++ ++   K +L+    +++L
Sbjct: 236  QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN---KGWLYGLRMLQQL 292

Query: 974  HLSHNKLKEIPPEI-GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFK 1032
            ++S N ++ I P+     + L+ LD+SYN   R   +    LS +  L L +  +     
Sbjct: 293  YVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVT---- 348

Query: 1033 HIGCKAKDIIRFLQQRLKKAVPYNRMKLMI--VGNTGSGKTTLLQQLMK-------TKKS 1083
            HI   A  + RFL       +  N +   I       +G T+L + +++       TKK+
Sbjct: 349  HI---ADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKA 405

Query: 1084 DLGMQS 1089
             +G++S
Sbjct: 406  FIGLES 411



>gi|40788371|dbj|BAA34526.2|   KIAA0806 protein [Homo sapiens]
          Length = 1073

 Score = 65.9 bits (159), Expect = 9e-10
 Identities = 91/366 (24%), Positives = 150/366 (40%), Gaps = 92/366 (25%)

Query: 784  ANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVP------ENLT----------- 826
            A LD S N +    +   +++  TL++  ++YN+L+ +P       N+T           
Sbjct: 86   AILDFSHNRLSNWNI---SLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPE 142

Query: 827  ------DVVEKLEQLILEGNKISGI-CSPLRLKELKILNLSKNHISSLSENFLEACPKVE 879
                       LE L L  N IS I  S     +LK LNLS N I++L     +      
Sbjct: 143  INAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDN----- 197

Query: 880  SFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPH------------------- 920
                          L  S+ ++KL++N+ S IP  I  LPH                   
Sbjct: 198  --------------LSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTF 243

Query: 921  -----LRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS--RVEKL 973
                 LRSL M  N I  L   A +   N+ EL   HN ++ ++   K +L+    +++L
Sbjct: 244  QGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN---KGWLYGLRMLQQL 300

Query: 974  HLSHNKLKEIPPEI-GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFK 1032
            ++S N ++ I P+     + L+ LD+SYN   R   +    LS +  L L +  +     
Sbjct: 301  YVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVT---- 356

Query: 1033 HIGCKAKDIIRFLQQRLKKAVPYNRMKLMI--VGNTGSGKTTLLQQLMK-------TKKS 1083
            HI   A  + RFL       +  N +   I       +G T+L + +++       TKK+
Sbjct: 357  HI---ADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKA 413

Query: 1084 DLGMQS 1089
             +G++S
Sbjct: 414  FIGLES 419



>gi|15131540|emb|CAC48387.1|   serine/threonine protein kinase [Homo sapiens]
          Length = 1231

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 58/196 (29%), Positives = 95/196 (48%), Gaps = 39/196 (19%)

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVL 1639
            +LV EL + G+L   L++ +    R LQ R +  +  GL +LHS +  I++RDLK  NV 
Sbjct: 239  VLVTELMTSGTLKTYLRRFREMKPRVLQ-RWSRQILRGLHFLHSRVPPILHRDLKCDNV- 296

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
             F   P  ++  KI D G+A        K+  GTP F APE+      Y++  DVY+FG+
Sbjct: 297  -FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEK--YDEAVDVYAFGM 351

Query: 1700 LLYDILTTG-------------GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746
             + ++ T+               ++  G K PN F +++I                P V+
Sbjct: 352  CMLEMATSEYPYSECQNAAQIYRKVTSGRK-PNSFHKVKI----------------PEVK 394

Query: 1747 KLIKQCLKENPQERPT 1762
            ++I+ C++ +  ER T
Sbjct: 395  EIIEGCIRTDKNERFT 410



>gi|631291|pir||S39793   MAPK-activated protein kinase 2 (EC 2.7.1.-) - human  (fragment)
 gi|407075|emb|CAA53094.1|   MAP kinase activated protein kinase-2 [Homo sapiens]
          Length = 396

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 59/201 (29%), Positives = 90/201 (44%), Gaps = 20/201 (9%)

Query: 1572 EFLLAGIRPRMLVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIY 1630
            E L AG +  ++VME    G L  R+  +   + T      I   + + ++YLHS  I +
Sbjct: 121  ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 180

Query: 1631 RDLKPHNVLLFTLYPNAAIIAKIADYGIA-QYCCRMGIKTSEGTPGFRAPEVARGNVIYN 1689
            RD+KP N+L  +  PNA  I K+ D+G A +      + T   TP + APEV  G   Y+
Sbjct: 181  RDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYD 237

Query: 1690 QQADVYSFGLLLYDIL--------TTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 1741
            +  D+   G+++Y +L          G  I  G+K      + E        V E     
Sbjct: 238  KSCDMLVLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE----- 292

Query: 1742 WPMVEKLIKQCLKENPQERPT 1762
               V+ LI+  LK  P +R T
Sbjct: 293  --EVKMLIRNLLKTEPTQRMT 311



>gi|182565|gb|AAA58470.1|   growth factor receptor
          Length = 731

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+  +                 LT       A  VA G+ YL 
Sbjct: 475  PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 534

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 535  SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 589

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L+   ++  P     C 
Sbjct: 590  -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 645

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783
                +  ++++C    P +RPT  Q+ + L+    V  T   L
Sbjct: 646  --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 686



>gi|53689008|gb|AAU89726.1|   fibroblast growth factor receptor 3 (achondroplasia, thanatophoric
            dwarfism) [Homo sapiens]
 gi|4503711|ref|NP_000133.1|   fibroblast growth factor receptor 3 isoform 1 precursor [Homo
            sapiens]
 gi|476557|pir||TVHUF3   fibroblast growth factor receptor 3 precursor - human
 gi|120050|sp|P22607|FGFR3_HUMAN   Fibroblast growth factor receptor 3 precursor (FGFR-3)
 gi|182569|gb|AAA52450.1|   fibroblast growth factor receptor
          Length = 806

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+  +                 LT       A  VA G+ YL 
Sbjct: 550  PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 609

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 610  SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 664

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L+   ++  P     C 
Sbjct: 665  -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 720

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783
                +  ++++C    P +RPT  Q+ + L+    V  T   L
Sbjct: 721  --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 761



>gi|2306915|gb|AAB65786.1|   protein kinase [Homo sapiens]
          Length = 347

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 56/188 (29%), Positives = 90/188 (47%), Gaps = 19/188 (10%)

Query: 1583 LVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVL 1639
            L++E A +G L + L +        T T++ RI   +AD L Y H   +I+RD+KP N+L
Sbjct: 152  LILEYAPRGMLYKELHKTCTFDEQRTATVR-RIMEELADALMYCHGKKVIHRDIKPENLL 210

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
            L           KIAD+G + +   +  KT  GT  +  PE+  G  ++N++ D++  G+
Sbjct: 211  L-----GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGV 264

Query: 1700 LLYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQ 1758
            L Y++L  G    E       +  + ++  K P  V           + LI + L+ NP 
Sbjct: 265  LCYELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPS 316

Query: 1759 ERPTSAQV 1766
            ER   AQV
Sbjct: 317  ERLPLAQV 324



>gi|20452381|gb|AAM22079.1|   fibroblast growth factor receptor 3 [Homo sapiens]
          Length = 771

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+  +                 LT       A  VA G+ YL 
Sbjct: 515  PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 574

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 575  SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 629

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L+   ++  P     C 
Sbjct: 630  -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 685

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783
                +  ++++C    P +RPT  Q+ + L+    V  T   L
Sbjct: 686  --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 726



>gi|20452380|gb|AAM22078.1|   fibroblast growth factor receptor 3 [Homo sapiens]
          Length = 769

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+  +                 LT       A  VA G+ YL 
Sbjct: 513  PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 572

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 573  SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 627

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L+   ++  P     C 
Sbjct: 628  -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 683

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783
                +  ++++C    P +RPT  Q+ + L+    V  T   L
Sbjct: 684  --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 724



>gi|21619202|gb|AAH32726.1|   Doublecortin and CaM kinase-like 2 [Homo sapiens]
 gi|22749267|ref|NP_689832.1|   doublecortin and CaM kinase-like 2 [Homo sapiens]
          Length = 695

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 60/193 (31%), Positives = 91/193 (47%), Gaps = 23/193 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVMEL   G L D +    K   T      +  ++A+ LRYLH   I++RD+KP N LL 
Sbjct: 466  LVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPEN-LLV 522

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              YP+     K+ D+G+A       + T  GTP + APE+      Y  + D+++ G++ 
Sbjct: 523  CEYPDGTKSLKLGDFGLAT-VVEGPLYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVIT 580

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPV----KEYGCAPWPMV----EKLIKQCL 1753
            Y IL  G        FP    E  +Q  L D +     E+    W  +    ++LI Q L
Sbjct: 581  Y-ILLCG--------FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 631

Query: 1754 KENPQERPTSAQV 1766
            + N + R T+ Q+
Sbjct: 632  QVNVEARCTAGQI 644



>gi|34365793|ref|NP_115763.2|   WNK lysine deficient protein kinase 4 [Homo sapiens]
 gi|15212448|gb|AAK91995.1|   putative protein kinase WNK4 [Homo sapiens]
 gi|41688789|sp|Q96J92|WNK4_HUMAN   Serine/threonine-protein kinase WNK4 (Protein kinase with no lysine
            4) (Protein kinase, lysine-deficient 4)
          Length = 1243

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 58/196 (29%), Positives = 95/196 (48%), Gaps = 39/196 (19%)

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM--IIYRDLKPHNVL 1639
            +LV EL + G+L   L++ +    R LQ R +  +  GL +LHS +  I++RDLK  NV 
Sbjct: 251  VLVTELMTSGTLKTYLRRFREMKPRVLQ-RWSRQILRGLHFLHSRVPPILHRDLKCDNV- 308

Query: 1640 LFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGL 1699
             F   P  ++  KI D G+A        K+  GTP F APE+      Y++  DVY+FG+
Sbjct: 309  -FITGPTGSV--KIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEK--YDEAVDVYAFGM 363

Query: 1700 LLYDILTTG-------------GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 1746
             + ++ T+               ++  G K PN F +++I                P V+
Sbjct: 364  CMLEMATSEYPYSECQNAAQIYRKVTSGRK-PNSFHKVKI----------------PEVK 406

Query: 1747 KLIKQCLKENPQERPT 1762
            ++I+ C++ +  ER T
Sbjct: 407  EIIEGCIRTDKNERFT 422



>gi|13112048|ref|NP_075254.1|   fibroblast growth factor receptor 3 isoform 2 precursor [Homo
            sapiens]
 gi|7533125|gb|AAF63380.1|   fibroblast growth factor receptor 3 [Homo sapiens]
          Length = 694

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 64/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%)

Query: 1580 PRMLVMELASKGSLDRLLQQDKA---------------SLTRTLQHRIALHVADGLRYLH 1624
            P  +++E A+KG+L   L+  +                 LT       A  VA G+ YL 
Sbjct: 438  PLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLA 497

Query: 1625 SAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGI--KTSEGTPGFR--APE 1680
            S   I+RDL   NVL+         + KIAD+G+A+    +    KT+ G    +  APE
Sbjct: 498  SQKCIHRDLAARNVLV-----TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPE 552

Query: 1681 VARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCA 1740
             A  + +Y  Q+DV+SFG+LL++I T GG    G+     F  L+   ++  P     C 
Sbjct: 553  -ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA---NCT 608

Query: 1741 PWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 1783
                +  ++++C    P +RPT  Q+ + L+    V  T   L
Sbjct: 609  --HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 649



>gi|4104411|gb|AAD02030.1|   Eph-like receptor tyrosine kinase hEphB1 [Homo sapiens]
          Length = 984

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 32/266 (12%)

Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            RP M++ E    G+LD  L+Q+    T      +   +A G++YL     ++RDL   N+
Sbjct: 691  RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 750

Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688
            L+     N+ ++ K++D+G+++Y   +   TS+ T            + APE A     +
Sbjct: 751  LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPE-AIAYRKF 801

Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748
               +DV+S+G+ +++++  G R    +   +  + +E   +LP P     C     + +L
Sbjct: 802  TSASDVWSYGIHMWEVMYFGERPYWDMSNQDVINAIEQDYRLPPPT---DCP--AALHQL 856

Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803
            +  C +++   RP  A++ + L     N A L  +     +P   +++  +         
Sbjct: 857  MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 916

Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829
              WL      + + SFL   T G+TS
Sbjct: 917  DDWLSAIKMVQYRDSFL---TAGFTS 939



>gi|4090841|gb|AAC98891.1|   serine/threonine kinase [Homo sapiens]
          Length = 347

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 56/187 (29%), Positives = 89/187 (47%), Gaps = 17/187 (9%)

Query: 1583 LVMELASKGSLDRLLQQDKA-SLTRTLQHRIALH-VADGLRYLHSAMIIYRDLKPHNVLL 1640
            L++E A +G L + LQ+       RT   R  +  +AD L Y H   +I+RD+KP N+LL
Sbjct: 152  LILEYAPRGMLYKELQKSCTFDEQRTATVRAVMEELADALMYCHGKKVIHRDIKPENLLL 211

Query: 1641 FTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 1700
                       KIAD+G + +   +  KT  GT  +  PE+  G  ++N++ D++  G+L
Sbjct: 212  -----GLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR-MHNEKVDLWCIGVL 265

Query: 1701 LYDILTTGGRIVEGLKFPNEFDEL-EIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQE 1759
             Y++L  G    E       +  + ++  K P  V           + LI + L+ NP E
Sbjct: 266  CYELL-VGNPPFESASHNETYRRIVKVDLKFPASVP-------TGAQDLISKLLRHNPSE 317

Query: 1760 RPTSAQV 1766
            R   AQV
Sbjct: 318  RLPLAQV 324



>gi|2739208|gb|AAB94627.1|   Eph-like receptor tyrosine kinase hEphB1c [Homo sapiens]
          Length = 943

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 61/266 (22%), Positives = 119/266 (44%), Gaps = 32/266 (12%)

Query: 1579 RPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV 1638
            RP M++ E    G+LD  L+Q+    T      +   +A G++YL     ++RDL   N+
Sbjct: 650  RPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNI 709

Query: 1639 LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGT----------PGFRAPEVARGNVIY 1688
            L+     N+ ++ K++D+G+++Y   +   TS+ T            + APE A     +
Sbjct: 710  LV-----NSNLVCKVSDFGLSRY---LQDDTSDPTYTSSLGGKIPVRWTAPE-AIAYRKF 760

Query: 1689 NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKL 1748
               +DV+S+G+ +++++  G R    +   +  + +E   +LP P     C     + +L
Sbjct: 761  TSASDVWSYGIHMWEVMYFGERPYWDMSNQDVINAIEQDYRLPPPT---DCP--AALHQL 815

Query: 1749 IKQCLKENPQERPTSAQVFDIL-----NSAELVCLTRRILLPKNVIVECMVATHHNSRNA 1803
            +  C +++   RP  A++ + L     N A L  +     +P   +++  +         
Sbjct: 816  MLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTV 875

Query: 1804 SIWLGCGHTDRGQLSFLDLNTEGYTS 1829
              WL      + + SFL   T G+TS
Sbjct: 876  DDWLSAIKMVQYRDSFL---TAGFTS 898



>gi|21740293|emb|CAD39156.1|   hypothetical protein [Homo sapiens]
          Length = 716

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 60/193 (31%), Positives = 91/193 (47%), Gaps = 23/193 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVMEL   G L D +    K   T      +  ++A+ LRYLH   I++RD+KP N LL 
Sbjct: 417  LVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPEN-LLV 473

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              YP+     K+ D+G+A       + T  GTP + APE+      Y  + D+++ G++ 
Sbjct: 474  CEYPDGTKSLKLGDFGLAT-VVEGPLYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVIT 531

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPV----KEYGCAPWPMV----EKLIKQCL 1753
            Y IL  G        FP    E  +Q  L D +     E+    W  +    ++LI Q L
Sbjct: 532  Y-ILLCG--------FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 582

Query: 1754 KENPQERPTSAQV 1766
            + N + R T+ Q+
Sbjct: 583  QVNVEARCTAGQI 595



>gi|59797954|sp|Q8N568|DCAK2_HUMAN   Serine/threonine-protein kinase DCAMKL2 (Doublecortin-like and CAM
            kinase-like 2)
          Length = 766

 Score = 65.5 bits (158), Expect = 1e-09
 Identities = 60/193 (31%), Positives = 91/193 (47%), Gaps = 23/193 (11%)

Query: 1583 LVMELASKGSL-DRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLF 1641
            LVMEL   G L D +    K   T      +  ++A+ LRYLH   I++RD+KP N LL 
Sbjct: 467  LVMELVKGGDLFDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPEN-LLV 523

Query: 1642 TLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLL 1701
              YP+     K+ D+G+A       + T  GTP + APE+      Y  + D+++ G++ 
Sbjct: 524  CEYPDGTKSLKLGDFGLAT-VVEGPLYTVCGTPTYVAPEII-AETGYGLKVDIWAAGVIT 581

Query: 1702 YDILTTGGRIVEGLKFPNEFDELEIQGKLPDPV----KEYGCAPWPMV----EKLIKQCL 1753
            Y IL  G        FP    E  +Q  L D +     E+    W  +    ++LI Q L
Sbjct: 582  Y-ILLCG--------FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQML 632

Query: 1754 KENPQERPTSAQV 1766
            + N + R T+ Q+
Sbjct: 633  QVNVEARCTAGQI 645



>gi|56204147|emb|CAI22320.1|   lymphocyte-specific protein tyrosine kinase [Homo sapiens]
 gi|6984209|gb|AAF34794.1|   tyrosine kinase LCK [Homo sapiens]
          Length = 496

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 66/237 (27%), Positives = 106/237 (44%), Gaps = 33/237 (13%)

Query: 1545 IAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLLQQDKAS 1603
            ++PD  LA+      L +  L       + +    P  ++ E    GSL D L       
Sbjct: 267  MSPDAFLAEANLMKQLQHQRL----VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIK 322

Query: 1604 LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIA---- 1659
            LT      +A  +A+G+ ++     I+RDL+  N+L+     +  +  KIAD+G+A    
Sbjct: 323  LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-----SDTLSCKIADFGLARLIE 377

Query: 1660 --QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKF 1717
              +Y  R G K       + APE       +  ++DV+SFG+LL +I+T G     G+  
Sbjct: 378  DNEYTAREGAKFPIK---WTAPEAINYGT-FTIKSDVWSFGILLTEIVTHGRIPYPGMTN 433

Query: 1718 PNEFDELEIQGKL--PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS 1772
            P     LE   ++  PD   E        + +L++ C KE P++RPT    FD L S
Sbjct: 434  PEVIQNLERGYRMVRPDNCPE-------ELYQLMRLCWKERPEDRPT----FDYLRS 479



>gi|66786|pir||OKHULK   protein-tyrosine kinase (EC 2.7.1.112) lck - human
 gi|28317393|tpe|CAD55807.1|   TPA: protein tyrosine kinase [Homo sapiens]
 gi|125474|sp|P06239|LCK_HUMAN   Proto-oncogene tyrosine-protein kinase LCK (P56-LCK) (LSK) (T
            cell-specific protein-tyrosine kinase)
 gi|825687|emb|CAA32211.1|   unnamed protein product [Homo sapiens]
          Length = 509

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 66/237 (27%), Positives = 106/237 (44%), Gaps = 33/237 (13%)

Query: 1545 IAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLLQQDKAS 1603
            ++PD  LA+      L +  L       + +    P  ++ E    GSL D L       
Sbjct: 280  MSPDAFLAEANLMKQLQHQRL----VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIK 335

Query: 1604 LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIA---- 1659
            LT      +A  +A+G+ ++     I+RDL+  N+L+     +  +  KIAD+G+A    
Sbjct: 336  LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-----SDTLSCKIADFGLARLIE 390

Query: 1660 --QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKF 1717
              +Y  R G K       + APE       +  ++DV+SFG+LL +I+T G     G+  
Sbjct: 391  DNEYTAREGAKFPIK---WTAPEAINYGT-FTIKSDVWSFGILLTEIVTHGRIPYPGMTN 446

Query: 1718 PNEFDELEIQGKL--PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS 1772
            P     LE   ++  PD   E        + +L++ C KE P++RPT    FD L S
Sbjct: 447  PEVIQNLERGYRMVRPDNCPE-------ELYQLMRLCWKERPEDRPT----FDYLRS 492



>gi|49457414|emb|CAG47006.1|   STK17B [Homo sapiens]
          Length = 372

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 51/186 (27%), Positives = 92/186 (49%), Gaps = 12/186 (6%)

Query: 1582 MLVMELASKGSLDRLLQQDKASLTRTLQH-RIALHVADGLRYLHSAMIIYRDLKPHNVLL 1640
            +L++E A+ G +  L   + A +       R+   + +G+ YLH   I++ DLKP N+LL
Sbjct: 107  ILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILL 166

Query: 1641 FTLYPNAAIIAKIADYGIAQ---YCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSF 1697
             ++YP   I  KI D+G+++   + C   ++   GTP + APE+   + I     D+++ 
Sbjct: 167  SSIYPLGDI--KIVDFGMSRKIGHACE--LREIMGTPEYLAPEILNYDPI-TTATDMWNI 221

Query: 1698 GLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENP 1757
            G++ Y +LT     V      N+   L I     D  +E   +   +    I+  L +NP
Sbjct: 222  GIIAYMLLTHTSPFVGE---DNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNP 278

Query: 1758 QERPTS 1763
            ++ PT+
Sbjct: 279  EKGPTA 284



>gi|50960723|gb|AAH75001.1|   V-yes-1 Yamaguchi sarcoma viral related oncogene homolog [Homo
            sapiens]
 gi|50960484|gb|AAH75002.1|   V-yes-1 Yamaguchi sarcoma viral related oncogene homolog [Homo
            sapiens]
 gi|4505055|ref|NP_002341.1|   v-yes-1 Yamaguchi sarcoma viral related oncogene homolog [Homo
            sapiens]
 gi|66782|pir||TVHULY   protein-tyrosine kinase (EC 2.7.1.112) lyn, splice form A - human
 gi|125480|sp|P07948|LYN_HUMAN   Tyrosine-protein kinase Lyn
 gi|307144|gb|AAA59540.1|   lyn tyrosine kinase
          Length = 512

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 60/202 (29%), Positives = 97/202 (48%), Gaps = 29/202 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D   K  L + +    +  +A+G+ Y+     I+RDL+  
Sbjct: 314  PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID--FSAQIAEGMAYIERKNYIHRDLRAA 371

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            NVL+     + +++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 372  NVLV-----SESLMCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGC-FTI 422

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LLY+I+T G     G    +    L    ++P   +   C     +  ++K
Sbjct: 423  KSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP---RVENCPD--ELYDIMK 477

Query: 1751 QCLKENPQERPTSAQVFDILNS 1772
             C KE  +ERPT    FD L S
Sbjct: 478  MCWKEKAEERPT----FDYLQS 495



>gi|187271|gb|AAB50019.1|   Lyn B protein [Homo sapiens]
 gi|741028|prf||2006286C   protein Tyr kinase LYN
          Length = 491

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 60/202 (29%), Positives = 97/202 (48%), Gaps = 29/202 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D   K  L + +    +  +A+G+ Y+     I+RDL+  
Sbjct: 293  PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID--FSAQIAEGMAYIERKNYIHRDLRAA 350

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            NVL+     + +++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 351  NVLV-----SESLMCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGC-FTI 401

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LLY+I+T G     G    +    L    ++P   +   C     +  ++K
Sbjct: 402  KSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP---RVENCPD--ELYDIMK 456

Query: 1751 QCLKENPQERPTSAQVFDILNS 1772
             C KE  +ERPT    FD L S
Sbjct: 457  MCWKEKAEERPT----FDYLQS 474



>gi|28372413|gb|AAO38055.1|   protein kinase, interferon-inducible double stranded RNA dependent
            [Homo sapiens]
 gi|4506103|ref|NP_002750.1|   eukaryotic translation initiation factor 2-alpha kinase 2 [Homo
            sapiens]
 gi|2136014|pir||JC5225   dsRNA-activated protein kinase (EC 2.7.1.-) - human
 gi|1537049|gb|AAC50768.1|   interferon-inducible RNA-dependent protein kinase [Homo sapiens]
 gi|125527|sp|P19525|E2AK2_HUMAN   Interferon-induced, double-stranded RNA-activated protein kinase
            (Interferon-inducible RNA-dependent protein kinase) (p68
            kinase) (P1/eIF-2A protein kinase)
 gi|189506|gb|AAA36409.1|   p68 kinase
 gi|189782|gb|AAA18253.1|   P1/eIF-2a protein kinase
          Length = 551

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 50/188 (26%), Positives = 93/188 (49%), Gaps = 19/188 (10%)

Query: 1585 MELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643
            ME   KG+L++ +++ +   L + L   +   +  G+ Y+HS  +I+RDLKP N+ L   
Sbjct: 366  MEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT 425

Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKT-SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                    KI D+G+       G +T S+GT  + +PE    +  Y ++ D+Y+ GL+L 
Sbjct: 426  KQ-----VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILA 479

Query: 1703 DILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
            ++L       E  KF   F +L   G + D   +         + L+++ L + P++RP 
Sbjct: 480  ELLHVCDTAFETSKF---FTDLR-DGIISDIFDK-------KEKTLLQKLLSKKPEDRPN 528

Query: 1763 SAQVFDIL 1770
            ++++   L
Sbjct: 529  TSEILRTL 536



>gi|37589566|gb|AAH59394.1|   LYN protein [Homo sapiens]
 gi|46250025|gb|AAH68551.1|   LYN protein [Homo sapiens]
          Length = 582

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 60/202 (29%), Positives = 97/202 (48%), Gaps = 29/202 (14%)

Query: 1580 PRMLVMELASKGSLDRLLQQD---KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH 1636
            P  ++ E  +KGSL   L+ D   K  L + +    +  +A+G+ Y+     I+RDL+  
Sbjct: 384  PIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID--FSAQIAEGMAYIERKNYIHRDLRAA 441

Query: 1637 NVLLFTLYPNAAIIAKIADYGIA------QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQ 1690
            NVL+     + +++ KIAD+G+A      +Y  R G K       + APE       +  
Sbjct: 442  NVLV-----SESLMCKIADFGLARVIEDNEYTAREGAKFPIK---WTAPEAINFGC-FTI 492

Query: 1691 QADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIK 1750
            ++DV+SFG+LLY+I+T G     G    +    L    ++P   +   C     +  ++K
Sbjct: 493  KSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMP---RVENCPD--ELYDIMK 547

Query: 1751 QCLKENPQERPTSAQVFDILNS 1772
             C KE  +ERPT    FD L S
Sbjct: 548  MCWKEKAEERPT----FDYLQS 565



>gi|31747519|gb|AAP57628.1|   interferon-inducible double-stranded RNA-dependent protein kinase
            [Homo sapiens]
          Length = 510

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 50/188 (26%), Positives = 93/188 (49%), Gaps = 19/188 (10%)

Query: 1585 MELASKGSLDRLLQQDKAS-LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL 1643
            ME   KG+L++ +++ +   L + L   +   +  G+ Y+HS  +I+RDLKP N+ L   
Sbjct: 325  MEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT 384

Query: 1644 YPNAAIIAKIADYGIAQYCCRMGIKT-SEGTPGFRAPEVARGNVIYNQQADVYSFGLLLY 1702
                    KI D+G+       G +T S+GT  + +PE    +  Y ++ D+Y+ GL+L 
Sbjct: 385  KQ-----VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILA 438

Query: 1703 DILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPT 1762
            ++L       E  KF   F +L   G + D   +         + L+++ L + P++RP 
Sbjct: 439  ELLHVCDTAFETSKF---FTDLR-DGIISDIFDK-------KEKTLLQKLLSKKPEDRPN 487

Query: 1763 SAQVFDIL 1770
            ++++   L
Sbjct: 488  TSEILRTL 495



>gi|5139790|dbj|BAA81737.1|   atrial natriuretic peptide Btype receptor [Homo sapiens]
          Length = 1047

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 60/216 (27%), Positives = 105/216 (48%), Gaps = 19/216 (8%)

Query: 1564 ELEFEQAPEFLLAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLR 1621
            +++F     F+ A I P    +V E   +GSL  +L+ D  +L    ++ +   +  G+ 
Sbjct: 573  DVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMA 632

Query: 1622 YLHSAMI-IYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPG---FR 1677
            +LH+++I  +  LK  N ++     ++  + KI DYG+A +        S        + 
Sbjct: 633  FLHNSIISSHGSLKSSNCVV-----DSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWT 687

Query: 1678 APEVARGNVIYN---QQADVYSFGLLLYDI-LTTGGRIVEGLKF-PNEFDELEIQGKLP- 1731
            APE+  GN +     Q+ADVYSFG++L +I L +G   +EGL   P E  +    G+ P 
Sbjct: 688  APELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPY 747

Query: 1732 -DPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQV 1766
              P  +       +V  L+++C  ++P ERP   Q+
Sbjct: 748  FRPSIDRSQLNEELV-LLMERCWAQDPAERPDFGQI 782



>gi|20428652|ref|NP_005347.2|   lymphocyte-specific protein tyrosine kinase [Homo sapiens]
 gi|34295|emb|CAA31884.1|   unnamed protein product [Homo sapiens]
          Length = 509

 Score = 65.1 bits (157), Expect = 2e-09
 Identities = 66/237 (27%), Positives = 106/237 (44%), Gaps = 33/237 (13%)

Query: 1545 IAPDLILADLPRNIMLNNDELEFEQAPEFLLAGIRPRMLVMELASKGSL-DRLLQQDKAS 1603
            ++PD  LA+      L +  L       + +    P  ++ E    GSL D L       
Sbjct: 280  MSPDAFLAEANLMKQLQHQRL----VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIK 335

Query: 1604 LTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIA---- 1659
            LT      +A  +A+G+ ++     I+RDL+  N+L+     +  +  KIAD+G+A    
Sbjct: 336  LTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV-----SDTLSCKIADFGLARLIE 390

Query: 1660 --QYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKF 1717
              +Y  R G K       + APE       +  ++DV+SFG+LL +I+T G     G+  
Sbjct: 391  DNEYTAREGAKFPIK---WTAPEAINYGT-FTIKSDVWSFGILLTEIVTHGRIPYPGMTN 446

Query: 1718 PNEFDELEIQGKL--PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNS 1772
            P     LE   ++  PD   E        + +L++ C KE P++RPT    FD L S
Sbjct: 447  PEVIQNLERGYRMVRPDNCPE-------ELYQLMRLCWKERPEDRPT----FDYLRS 492






  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF excluding environmental samples
    Posted date:  Mar 15, 2005 10:11 AM
  Number of letters in database: 802,797,248
  Number of sequences in database:  2,367,365
  
Lambda     K      H
   0.321    0.136    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,565,578
Number of Sequences: 2367365
Number of extensions: 1145734
Number of successful extensions: 3669
Number of sequences better than 10.0: 440
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 294
Number of HSP's that attempted gapping in prelim test: 2834
Number of HSP's gapped (non-prelim): 685
length of query: 2111
length of database: 46,038,991
effective HSP length: 123
effective length of query: 1988
effective length of database: 30,031,648
effective search space: 59702916224
effective search space used: 59702916224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)







 


 
Format
  


 


 
Show
  Graphical OverviewLinkoutSequence RetrievalNCBI-giAlignmentPSSMBioseq in HTMLPlain textASN.1XMLformat


 


 
Use new formatter
  Masking CharacterDefault(X for protein, n for nucleotide)Lower Case
Masking ColorBlackGreyRed



 


 
Number of:
  Descriptions01050100250500
Alignments01050100250500



 


 
Alignment view
  PairwisePairwise with identitiesquery-anchored with identitiesquery-anchored without identitiesflat query-anchored with identitiesflat query-anchored without identitiesHit Table


 


 
Format for PSI-BLAST
  with inclusion threshold:


 


 
Limit results by entrez query
   or select from:All organismsViruses [ORGN]Archaea [ORGN]Bacteria [ORGN]Eukaryota [ORGN]Viridiplantae [ORGN]Fungi [ORGN]Metazoa [ORGN]Arthropoda [ORGN]Vertebrata [ORGN]Mammalia [ORGN]Rodentia [ORGN]Primates [ORGN]-------------------Aeropyrum pernix [ORGN]Aquifex aeolicus [ORGN]Arabidopsis thaliana [ORGN]Bacillus subtilis [ORGN]Bos taurus [ORGN]Caenorhabditis elegans [ORGN]Canis familiaris[ORGN]Danio rerio [ORGN]Dictyostelium discoideum [ORGN]Drosophila melanogaster [ORGN]Escherichia coli [ORGN]Gallus gallus [ORGN]Homo sapiens [ORGN]Human immunodeficiency virus type 1 [ORGN]Methanococcus jannaschii [ORGN]Mus musculus [ORGN]Oryctolagus cuniculus [ORGN]Oryza sativa [ORGN]Ovis aries [ORGN]Plasmodium falciparum [ORGN]Rattus norvegicus [ORGN]Saccharomyces cerevisiae [ORGN]Schizosaccharomyces pombe [ORGN]Xenopus tropicalis[ORGN]Simian immunodeficiency virus [ORGN]Sus scrofa[ORGN]Synechocystis PCC6803 [ORGN]Takifugu rubripes [ORGN]Xenopus laevis [ORGN]Zea mays [ORGN]


 


 
Expect value range:
    







 or