BLASTP 2.2.10 [Oct-19-2004] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. RID: 1111134056-29364-76162250300.BLASTQ2 Query= FGENESH: 6 26 exon (s) 249419 - 372401 1347 aa, chain - (1347 letters) Database: Non-redundant SwissProt sequences 164,271 sequences; 60,490,055 total letters Score E Sequences producing significant alignments: (bits) Value gi|113992|sp|P02647|APOA1_HUMAN Apolipoprotein A-I precursor (Ap... 475 e-134 gi|59798973|sp|Q9H0K1|SN1L2_HUMAN Serine/threonine-protein kinas... 363 e-100 gi|59803093|sp|P57059|SN1L1_HUMAN Serine/threonine-protein kinas... 330 2e-90 gi|29840797|sp|Q96L34|MARK4_HUMAN MAP/microtubule affinity-regul... 325 5e-89 gi|29337165|sp|P27448|MARK3_HUMAN MAP/microtubule affinity-regul... 315 9e-86 gi|34395849|sp|Q8IWQ3|BRSK2_HUMAN BR serine/threonine-protein ki... 244 2e-64 gi|34395684|sp|Q8TDC3|KI11_HUMAN Probable serine/threonine-prote... 243 4e-64 gi|20178276|sp|P54646|AAPK2_HUMAN 5'-AMP-activated protein kinas... 238 8e-63 gi|20178277|sp|Q13131|AAPK1_HUMAN 5'-AMP-activated protein kinas... 238 1e-62 gi|14424095|sp|O60285|ARK5_HUMAN AMPK-related protein kinase 5 224 2e-58 gi|50400857|sp|Q14680|MELK_HUMAN Maternal embryonic leucine zipp... 195 8e-50 gi|30316282|sp|Q9BXA7|ST22A_HUMAN Serine/threonine-protein kinas... 186 6e-47 gi|30316269|sp|Q96PF2|ST22B_HUMAN Serine/threonine-protein kinas... 168 1e-41 gi|9973393|sp|P57058|HUNK_HUMAN Hormonally up-regulated neu tumo... 166 4e-41 gi|30316270|sp|Q96PN8|ST22C_HUMAN Serine/threonine-protein kinas... 164 2e-40 gi|27805738|sp|Q9UQB9|AURKC_HUMAN Serine/threonine-protein kinas... 162 6e-40 gi|2499586|sp|Q16566|KCC4_HUMAN Calcium/calmodulin-dependent pro... 160 4e-39 gi|3122301|sp|Q14012|KCC1A_HUMAN Calcium/calmodulin-dependent pr... 156 4e-38 gi|56404610|sp|Q8IU85|KCC1D_HUMAN Calcium/calmodulin-dependent p... 150 2e-36 gi|27923855|sp|O14965|STK6_HUMAN Serine/threonine-protein kinase... 149 5e-36 gi|27805737|sp|Q96GD4|AURKB_HUMAN Serine/threonine-protein kinas... 148 1e-35 gi|125536|sp|P15735|PHKG2_HUMAN Phosphorylase b kinase gamma cat... 146 6e-35 gi|6685284|sp|O96017|CHK2_HUMAN Serine/threonine-protein kinase ... 145 1e-34 gi|17379144|sp|P11801|KPSH1_HUMAN Serine/threonine-protein kinas... 143 5e-34 gi|2833281|sp|Q16816|PHKG1_HUMAN Phosphorylase b kinase gamma ca... 142 6e-34 gi|38605718|sp|P53355|DAPK1_HUMAN Death-associated protein kinas... 142 6e-34 gi|20177970|sp|Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent p... 141 2e-33 gi|56404655|sp|Q96NX5|KCC1G_HUMAN Calcium/calmodulin-dependent p... 140 2e-33 gi|7531055|sp|O14757|CHK1_HUMAN Serine/threonine-protein kinase ... 140 4e-33 gi|12643414|sp|Q13557|KCC2D_HUMAN Calcium/calmodulin-dependent p... 139 5e-33 gi|51316189|sp|O00444|PLK4_HUMAN Serine/threonine-protein kinase... 139 5e-33 gi|38604691|sp|O43293|DAPK3_HUMAN Death-associated protein kinas... 139 9e-33 gi|12643413|sp|Q13554|KCC2B_HUMAN Calcium/calmodulin-dependent p... 139 9e-33 gi|20178304|sp|Q13555|KCC2G_HUMAN Calcium/calmodulin-dependent p... 138 1e-32 gi|37999482|sp|O75582|KS6A5_HUMAN Ribosomal protein S6 kinase al... 136 4e-32 gi|6136124|sp|O75385|ULK1_HUMAN Serine/threonine-protein kinase ... 136 4e-32 gi|6225242|sp|O15075|DCAK1_HUMAN Serine/threonine-protein kinase... 135 1e-31 gi|1170703|sp|P31751|AKT2_HUMAN RAC-beta serine/threonine-protei... 133 4e-31 gi|125210|sp|P22694|KAPCB_HUMAN cAMP-dependent protein kinase, b... 132 1e-30 gi|38605084|sp|Q9UIK4|DAPK2_HUMAN Death-associated protein kinas... 131 1e-30 gi|11133131|sp|Q9UK32|KS6A6_HUMAN Ribosomal protein S6 kinase al... 131 2e-30 gi|59797954|sp|Q8N568|DCAK2_HUMAN Serine/threonine-protein kinas... 131 2e-30 gi|12643943|sp|Q9Y243|AKT3_HUMAN RAC-gamma serine/threonine-prot... 130 2e-30 gi|14423930|sp|Q9UEE5|ST17A_HUMAN Serine/threonine-protein kinas... 130 2e-30 gi|1709648|sp|P51817|PRKX_HUMAN Serine/threonine-protein kinase ... 130 4e-30 gi|1346538|sp|P49137|MAPK2_HUMAN MAP kinase-activated protein ki... 129 5e-30 gi|33860173|sp|P22612|KAPCG_HUMAN cAMP-dependent protein kinase,... 129 5e-30 gi|125205|sp|P17612|KAPCA_HUMAN cAMP-dependent protein kinase, a... 128 1e-29 gi|20141585|sp|Q05513|KPCZ_HUMAN Protein kinase C, zeta type (nP... 127 2e-29 gi|37999483|sp|O75676|KS6A4_HUMAN Ribosomal protein S6 kinase al... 126 5e-29 gi|60391226|sp|P31749|AKT1_HUMAN RAC-alpha serine/threonine-prot... 126 6e-29 gi|27735175|sp|O14936|CSKP_HUMAN Peripheral plasma membrane prot... 126 6e-29 gi|6226833|sp|Q13237|KGP2_HUMAN cGMP-dependent protein kinase 2 ... 124 2e-28 gi|1730070|sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alp... 124 2e-28 gi|51338822|sp|Q9H4B4|PLK3_HUMAN Serine/threonine-protein kinase... 123 4e-28 gi|1170688|sp|P41743|KPCI_HUMAN Protein kinase C, iota type (nPK... 123 5e-28 gi|41017453|sp|O43930|PRKY_HUMAN Serine/threonine-protein kinase... 122 7e-28 gi|20178306|sp|Q15418|KS6A1_HUMAN Ribosomal protein S6 kinase al... 122 7e-28 gi|22096374|sp|Q9NYY3|PLK2_HUMAN Serine/threonine-protein kinase... 122 9e-28 gi|6166243|sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alp... 121 2e-27 gi|1346393|sp|P24723|KPCL_HUMAN Protein kinase C, eta type (nPKC... 120 3e-27 gi|41017502|sp|Q96RG2|PASK_HUMAN PAS domain containing serine/th... 120 3e-27 gi|34098463|sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase... 119 1e-26 gi|1709658|sp|P53350|PLK1_HUMAN Serine/threonine-protein kinase ... 117 2e-26 gi|56404656|sp|Q96RR4|KKCC2_HUMAN Calcium/calmodulin-dependent p... 117 2e-26 gi|125549|sp|P17252|KPCA_HUMAN Protein kinase C, alpha type (PKC... 117 3e-26 gi|400135|sp|Q02156|KPCE_HUMAN Protein kinase C, epsilon type (n... 116 6e-26 gi|3024670|sp|Q15831|STK11_HUMAN Serine/threonine-protein kinase... 116 6e-26 gi|462455|sp|P05129|KPCG_HUMAN Protein kinase C, gamma type (PKC... 115 1e-25 gi|56404620|sp|Q8N5S9|KKCC1_HUMAN Calcium/calmodulin-dependent p... 115 1e-25 gi|2499575|sp|Q15139|KPCM_HUMAN Protein kinase C, mu type (nPKC-... 115 1e-25 gi|28558166|sp|Q9HBY8|SGK2_HUMAN Serine/threonine-protein kinase... 114 2e-25 gi|125379|sp|P14619|KGP1B_HUMAN cGMP-dependent protein kinase 1,... 114 2e-25 gi|6225588|sp|Q13976|KGP1A_HUMAN cGMP-dependent protein kinase 1... 114 2e-25 gi|20138711|sp|Q9BZL6|KPCD2_HUMAN Protein kinase C, D2 type (nPK... 113 5e-25 gi|20141488|sp|P05771|KPCB_HUMAN Protein kinase C, beta type (PK... 113 5e-25 gi|17380162|sp|O15530|PDPK1_HUMAN 3-phosphoinositide dependent p... 112 9e-25 gi|52000829|sp|Q8IW41|MAPK5_HUMAN MAP kinase-activated protein k... 112 1e-24 gi|24211884|sp|Q9H1R3|MYLK2_HUMAN Myosin light chain kinase 2, s... 111 2e-24 gi|12230239|sp|O94806|KPCN_HUMAN Protein kinase C, nu type (nPKC... 110 3e-24 gi|3041712|sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase ... 110 3e-24 gi|1709252|sp|P51955|NEK2_HUMAN Serine/threonine-protein kinase ... 109 6e-24 gi|2499643|sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase ... 109 6e-24 gi|12644418|sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smoo... 109 6e-24 gi|20141582|sp|Q04759|KPCT_HUMAN Protein kinase C, theta type (n... 109 8e-24 gi|60390226|sp|Q9Y2H9|MAST1_HUMAN Microtubule-associated serine/... 109 8e-24 gi|22256934|sp|Q96PY6|NEK1_HUMAN Serine/threonine-protein kinase... 108 1e-23 gi|3914977|sp|O00141|SGK1_HUMAN Serine/threonine-protein kinase ... 108 1e-23 gi|56405369|sp|Q00532|KKIA_HUMAN Serine/threonine-protein kinase... 108 1e-23 gi|6225859|sp|Q16513|PKL2_HUMAN Protein kinase N2 (Protein kinas... 108 1e-23 gi|38502964|sp|Q86V86|PIM3_HUMAN Serine/threonine-protein kinase... 107 2e-23 gi|54041234|sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 ... 107 3e-23 gi|14423909|sp|O94768|ST17B_HUMAN Serine/threonine-protein kinas... 107 4e-23 gi|12643872|sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 ... 107 4e-23 gi|125565|sp|P11309|PIM1_HUMAN Proto-oncogene serine/threonine-p... 106 5e-23 gi|47117818|sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase... 106 6e-23 gi|8928460|sp|O75962|TRIO_HUMAN Triple functional domain protein... 105 1e-22 gi|20139243|sp|Q9P1W9|PIM2_HUMAN Serine/threonine-protein kinase... 104 2e-22 gi|28558163|sp|Q96BR1|SGK3_HUMAN Serine/threonine-protein kinase... 104 2e-22 gi|47605999|sp|Q13464|ROCK1_HUMAN Rho-associated protein kinase ... 103 4e-22 gi|13626607|sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinas... 102 9e-22 gi|12643529|sp|O00506|STK25_HUMAN Serine/threonine-protein kinas... 102 9e-22 gi|6174910|sp|Q16512|PKL1_HUMAN Protein kinase N1 (Protein kinas... 102 9e-22 gi|547803|sp|Q05655|KPCD_HUMAN Protein kinase C, delta type (nPK... 102 9e-22 gi|30316125|sp|Q9HBH9|MKNK2_HUMAN MAP kinase-interacting serine/... 102 1e-21 gi|12585288|sp|O96013|PAK4_HUMAN Serine/threonine-protein kinase... 100 3e-21 gi|231726|sp|Q00526|CDK3_HUMAN Cell division protein kinase 3 100 5e-21 gi|20178297|sp|P51956|NEK3_HUMAN Serine/threonine-protein kinase... 99 8e-21 gi|12585290|sp|Q9P286|PAK7_HUMAN Serine/threonine-protein kinase... 98 2e-20 gi|6175070|sp|O76039|CDKL5_HUMAN Serine/threonine-protein kinase... 97 4e-20 gi|1705489|sp|P51813|BMX_HUMAN Cytoplasmic tyrosine-protein kina... 97 5e-20 gi|47605963|sp|O75116|ROCK2_HUMAN Rho-associated protein kinase ... 97 5e-20 gi|34098605|sp|Q8TD19|NEK9_HUMAN Serine/threonine-protein kinase... 95 1e-19 gi|2499640|sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase... 95 1e-19 gi|4033704|sp|Q00535|CDK5_HUMAN Cell division protein kinase 5 (... 95 2e-19 gi|115922|sp|P06493|CDC2_HUMAN Cell division control protein 2 h... 95 2e-19 gi|6685620|sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase... 95 2e-19 gi|6685621|sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase... 94 3e-19 gi|12643825|sp|Q9NYV4|CD2L7_HUMAN Cell division cycle 2-related ... 94 3e-19 gi|3915762|sp|P53667|LIK1_HUMAN LIM domain kinase 1 (LIMK-1) 94 4e-19 gi|116051|sp|P24941|CDK2_HUMAN Cell division protein kinase 2 (p... 93 6e-19 gi|1709347|sp|P51957|NEK4_HUMAN Serine/threonine-protein kinase ... 93 6e-19 gi|23396789|sp|Q9NQU5|PAK6_HUMAN Serine/threonine-protein kinase... 92 1e-18 gi|46577700|sp|Q13188|STK3_HUMAN Serine/threonine-protein kinase... 91 3e-18 gi|56749668|sp|Q9Y2H1|ST38L_HUMAN Serine/threonine-protein kinas... 91 3e-18 gi|13124559|sp|Q13043|STK4_HUMAN Serine/threonine-protein kinase... 91 3e-18 gi|2833269|sp|Q15835|RK_HUMAN Rhodopsin kinase (RK) (G protein-c... 91 4e-18 gi|12643880|sp|Q9UEW8|STK39_HUMAN STE20/SPS1-related proline-ala... 90 6e-18 gi|1708824|sp|P53671|LIK2_HUMAN LIM domain kinase 2 (LIMK-2) 89 1e-17 gi|57015279|sp|O14578|CTRO_HUMAN Citron Rho-interacting kinase (... 89 1e-17 gi|10719935|sp|Q14004|CD2L5_HUMAN Cell division cycle 2-like pro... 89 1e-17 gi|30316115|sp|Q9BUB5|MKNK1_HUMAN MAP kinase-interacting serine/... 87 3e-17 gi|46396051|sp|Q9Y2A5|DUET_HUMAN Serine/threonine-protein kinase... 87 4e-17 gi|1170598|sp|P45984|MK09_HUMAN Mitogen-activated protein kinase... 87 5e-17 gi|14285497|sp|O14920|IKKB_HUMAN Inhibitor of nuclear factor kap... 87 5e-17 gi|8488988|sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase... 86 7e-17 gi|125480|sp|P07948|LYN_HUMAN Tyrosine-protein kinase Lyn 86 7e-17 gi|12643358|sp|O94804|STK10_HUMAN Serine/threonine-protein kinas... 86 7e-17 gi|20178302|sp|Q07002|PCTK3_HUMAN Serine/threonine-protein kinas... 86 1e-16 gi|34222826|sp|Q86UE8|TLK2_HUMAN Serine/threonine-protein kinase... 86 1e-16 gi|114006|sp|P06727|APOA4_HUMAN Apolipoprotein A-IV precursor (A... 86 1e-16 gi|56749457|sp|Q15208|STK38_HUMAN Serine/threonine-protein kinas... 85 2e-16 gi|462203|sp|P34947|GRK5_HUMAN G protein-coupled receptor kinase... 85 2e-16 gi|1706450|sp|Q09013|DMPK_HUMAN Myotonin-protein kinase (Myotoni... 85 2e-16 gi|14285498|sp|O15111|IKKA_HUMAN Inhibitor of nuclear factor kap... 84 3e-16 gi|59803097|sp|Q00537|PCTK2_HUMAN Serine/threonine-protein kinas... 84 3e-16 gi|20141386|sp|P43250|GRK6_HUMAN G protein-coupled receptor kina... 84 3e-16 gi|125351|sp|P16591|FER_HUMAN Proto-oncogene tyrosine-protein ki... 84 3e-16 gi|1169745|sp|P42685|FRK_HUMAN Tyrosine-protein kinase FRK (Nucl... 84 3e-16 gi|266425|sp|Q00536|PCTK1_HUMAN Serine/threonine-protein kinase ... 83 6e-16 gi|125474|sp|P06239|LCK_HUMAN Proto-oncogene tyrosine-protein ki... 83 6e-16 gi|34223086|sp|Q9UKI8|TLK1_HUMAN Serine/threonine-protein kinase... 82 1e-15 gi|464971|sp|P33981|TTK_HUMAN Dual specificity protein kinase TT... 82 1e-15 gi|19857975|sp|P29322|EPHA8_HUMAN Ephrin type-A receptor 8 precu... 82 1e-15 gi|8928302|sp|Q13882|PTK6_HUMAN Tyrosine-protein kinase 6 (Breas... 82 1e-15 gi|41688789|sp|Q96J92|WNK4_HUMAN Serine/threonine-protein kinase... 82 1e-15 gi|125135|sp|P00519|ABL1_HUMAN Proto-oncogene tyrosine-protein k... 82 2e-15 gi|1351326|sp|P42681|TXK_HUMAN Tyrosine-protein kinase TXK 82 2e-15 gi|2507195|sp|P45983|MK08_HUMAN Mitogen-activated protein kinase... 81 2e-15 gi|29427817|sp|Q8IVH8|M4K3_HUMAN Mitogen-activated protein kinas... 81 2e-15 gi|1730068|sp|P10398|ARAF_HUMAN A-Raf proto-oncogene serine/thre... 81 3e-15 gi|2507196|sp|P53779|MK10_HUMAN Mitogen-activated protein kinase... 81 3e-15 gi|1168268|sp|P42684|ABL2_HUMAN Tyrosine-protein kinase ABL2 (Ty... 80 4e-15 gi|41688795|sp|Q9H4A3|WNK1_HUMAN Serine/threonine-protein kinase... 80 4e-15 gi|27805732|sp|Q9H3Y6|SRMS_HUMAN Tyrosine-protein kinase Srms 80 4e-15 gi|125651|sp|P04049|RAF1_HUMAN RAF proto-oncogene serine/threoni... 80 5e-15 gi|50403720|sp|P15056|BRAF1_HUMAN B-Raf proto-oncogene serine/th... 80 5e-15 gi|12643557|sp|O43318|M3K7_HUMAN Mitogen-activated protein kinas... 80 5e-15 gi|41688792|sp|Q9BYP7|WNK3_HUMAN Serine/threonine-protein kinase... 80 5e-15 gi|50400798|sp|Q9UBE8|NLK_HUMAN Serine/threonine kinase NLK (Nem... 80 6e-15 gi|2851522|sp|P53778|MK12_HUMAN Mitogen-activated protein kinase... 80 6e-15 gi|12644292|sp|P49840|GSK3A_HUMAN Glycogen synthase kinase-3 alp... 80 6e-15 gi|125711|sp|P12931|SRC_HUMAN Proto-oncogene tyrosine-protein ki... 80 6e-15 gi|37537965|sp|Q8TDX7|NEK7_HUMAN Serine/threonine-protein kinase... 80 6e-15 gi|2499600|sp|Q16539|MK14_HUMAN Mitogen-activated protein kinase... 79 8e-15 gi|29840818|sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK interacting kinase 79 8e-15 gi|41688799|sp|Q9Y3S1|WNK2_HUMAN Serine/threonine-protein kinase... 79 8e-15 gi|29427834|sp|Q8N4C8|M4K6_HUMAN Mitogen-activated protein kinas... 79 1e-14 gi|400274|sp|Q02750|MP2K1_HUMAN Dual specificity mitogen-activat... 78 2e-14 gi|20141296|sp|P08631|HCK_HUMAN Tyrosine-protein kinase HCK (p59... 78 2e-14 gi|125370|sp|P06241|FYN_HUMAN Proto-oncogene tyrosine-protein ki... 77 3e-14 gi|45593475|sp|Q12851|M4K2_HUMAN Mitogen-activated protein kinas... 77 3e-14 gi|543848|sp|P35626|ARBK2_HUMAN Beta-adrenergic receptor kinase ... 77 3e-14 gi|1174630|sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec 77 3e-14 gi|37537993|sp|Q9HC98|NEK6_HUMAN Serine/threonine-protein kinase... 77 4e-14 gi|585361|sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (T... 77 4e-14 gi|22653927|sp|O94921|PFTK1_HUMAN Serine/threonine-protein kinas... 77 5e-14 gi|1705485|sp|P51451|BLK_HUMAN Tyrosine-protein kinase BLK (B ly... 77 5e-14 gi|28201830|sp|Q96RU7|TRIB3_HUMAN Tribbles homolog 3 (TRB-3) (Ne... 76 7e-14 gi|547759|sp|Q06187|BTK_HUMAN Tyrosine-protein kinase BTK (Bruto... 76 7e-14 gi|29427585|sp|O95819|M4K4_HUMAN Mitogen-activated protein kinas... 76 7e-14 gi|2499633|sp|Q13163|MP2K5_HUMAN Dual specificity mitogen-activa... 76 9e-14 gi|125870|sp|P07947|YES_HUMAN Proto-oncogene tyrosine-protein ki... 76 9e-14 gi|30316147|sp|Q9Y4K4|M4K5_HUMAN Mitogen-activated protein kinas... 76 9e-14 gi|114152|sp|P25098|ARBK1_HUMAN Beta-adrenergic receptor kinase ... 75 1e-13 gi|125387|sp|P29320|EPHA3_HUMAN Ephrin type-A receptor 3 precurs... 75 1e-13 gi|3183518|sp|Q05397|FAK1_HUMAN Focal adhesion kinase 1 (FADK 1)... 75 1e-13 gi|400127|sp|P07332|FES_HUMAN Proto-oncogene tyrosine-protein ki... 75 1e-13 gi|21263659|sp|Q8WTQ7|GRK7_HUMAN G protein-coupled receptor kina... 75 1e-13 gi|399448|sp|P31152|MK04_HUMAN Mitogen-activated protein kinase ... 75 2e-13 gi|729887|sp|P41240|CSK_HUMAN Tyrosine-protein kinase CSK (C-SRC... 74 3e-13 gi|20141243|sp|P50750|CDK9_HUMAN Cell division protein kinase 9 ... 74 3e-13 gi|1706628|sp|P54756|EPHA5_HUMAN Ephrin type-A receptor 5 precur... 74 3e-13 gi|46577075|sp|Q8NEV4|MYO3A_HUMAN Myosin IIIA 74 4e-13 gi|18202489|sp|Q12852|M3K12_HUMAN Mitogen-activated protein kina... 74 4e-13 gi|20455502|sp|P49841|GSK3B_HUMAN Glycogen synthase kinase-3 bet... 74 5e-13 gi|48428273|sp|Q9UPZ9|ICK_HUMAN Serine/threonine kinase ICK (Int... 73 6e-13 gi|125358|sp|P09769|FGR_HUMAN Proto-oncogene tyrosine-protein ki... 73 6e-13 gi|120049|sp|P21802|FGFR2_HUMAN Fibroblast growth factor recepto... 73 8e-13 gi|232066|sp|P27361|MK03_HUMAN Mitogen-activated protein kinase ... 72 1e-12 gi|1706663|sp|P54762|EPHB1_HUMAN Ephrin type-B receptor 1 precur... 72 1e-12 gi|1705722|sp|P50613|CDK7_HUMAN Cell division protein kinase 7 (... 72 1e-12 gi|13432166|sp|P20794|MAK_HUMAN Serine/threonine-protein kinase ... 72 1e-12 gi|14548079|sp|Q14164|IKKE_HUMAN Inhibitor of nuclear factor kap... 72 1e-12 gi|119554|sp|P28482|MK01_HUMAN Mitogen-activated protein kinase ... 72 2e-12 gi|1177044|sp|P43403|ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 ... 71 2e-12 gi|547915|sp|P36507|MP2K2_HUMAN Dual specificity mitogen-activat... 71 2e-12 gi|120046|sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor r... 71 2e-12 gi|1711371|sp|P54764|EPHA4_HUMAN Ephrin type-A receptor 4 precur... 71 2e-12 gi|6166188|sp|P32298|GRK4_HUMAN G protein-coupled receptor kinas... 71 2e-12 gi|52783106|sp|O95835|LATS1_HUMAN Serine/threonine protein kinas... 71 2e-12 gi|2499603|sp|Q15759|MK11_HUMAN Mitogen-activated protein kinase... 71 2e-12 gi|20455241|sp|Q9Y572|RIPK3_HUMAN Receptor-interacting serine/th... 71 2e-12 gi|17375734|sp|O14976|GAK_HUMAN Cyclin G-associated kinase 71 2e-12 gi|12644190|sp|P29323|EPHB2_HUMAN Ephrin type-B receptor 2 precu... 71 2e-12 gi|56405328|sp|P29597|TYK2_HUMAN Non-receptor tyrosine-protein k... 71 3e-12 gi|2499596|sp|Q16659|MK06_HUMAN Mitogen-activated protein kinase... 71 3e-12 gi|2497572|sp|Q15375|EPHA7_HUMAN Ephrin type-A receptor 7 precur... 71 3e-12 gi|6685617|sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase... 70 4e-12 gi|47117832|sp|P21709|EPHA1_HUMAN Ephrin type-A receptor 1 precu... 70 4e-12 gi|12643404|sp|O60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (J... 70 5e-12 gi|125333|sp|P29317|EPHA2_HUMAN Ephrin type-A receptor 2 precurs... 70 5e-12 gi|52783149|sp|Q9NRM7|LATS2_HUMAN Serine/threonine protein kinas... 70 5e-12 gi|2499660|sp|Q15569|TESK1_HUMAN Dual-specificity testis-specifi... 70 7e-12 gi|6831583|sp|O14733|MP2K7_HUMAN Dual specificity mitogen-activa... 70 7e-12 gi|1168867|sp|P11802|CDK4_HUMAN Cell division protein kinase 4 (... 70 7e-12 gi|46577085|sp|Q8WXR4|MYO3B_HUMAN Myosin IIIB 70 7e-12 gi|6685642|sp|O15264|MK13_HUMAN Mitogen-activated protein kinase... 69 1e-11 gi|60393639|sp|Q13546|RIPK1_HUMAN Receptor-interacting serine/th... 69 1e-11 gi|1708164|sp|P54753|EPHB3_HUMAN Ephrin type-B receptor 3 precur... 69 1e-11 gi|24211444|sp|Q96Q40|AL2S7_HUMAN Serine/threonine-protein kinas... 69 1e-11 gi|1174527|sp|P43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Spl... 69 1e-11 gi|50403745|sp|P52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (J... 68 2e-11 gi|1170596|sp|P45985|MP2K4_HUMAN Dual specificity mitogen-activa... 68 2e-11 gi|1345718|sp|P49336|CDK8_HUMAN Cell division protein kinase 8 (... 68 2e-11 gi|60391917|sp|Q9BWU1|CD2L6_HUMAN Cell division cycle 2-like pro... 68 2e-11 gi|549081|sp|P35590|TIE1_HUMAN Tyrosine-protein kinase receptor ... 68 3e-11 gi|32172458|sp|Q9BQI3|E2K1_HUMAN Eukaryotic translation initiati... 67 3e-11 gi|266423|sp|Q00534|CDK6_HUMAN Cell division protein kinase 6 (S... 67 3e-11 gi|2497562|sp|Q16288|NTRK3_HUMAN NT-3 growth factor receptor pre... 67 3e-11 gi|6685614|sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase... 67 3e-11 gi|119534|sp|P21860|ERBB3_HUMAN Receptor tyrosine-protein kinase... 67 4e-11 gi|19860819|sp|P54760|EPHB4_HUMAN Ephrin type-B receptor 4 precu... 67 6e-11 gi|25009462|sp|Q96S53|TESK2_HUMAN Dual specificity testis-specif... 67 6e-11 gi|2497560|sp|Q16620|NTRK2_HUMAN BDNF/NT-3 growth factors recept... 67 6e-11 gi|23831382|sp|Q13523|PRP4B_HUMAN Serine/threonine-protein kinas... 67 6e-11 gi|50401181|sp|Q9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associa... 66 7e-11 gi|462606|sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase ... 66 7e-11 gi|55976573|sp|Q99640|PMYT1_HUMAN Membrane-associated tyrosine-a... 66 7e-11 gi|120050|sp|P22607|FGFR3_HUMAN Fibroblast growth factor recepto... 66 7e-11 gi|55977123|sp|P68400|CSK21_HUMAN Casein kinase II, alpha chain ... 66 7e-11 gi|34922255|sp|Q9UQ88|CD2L2_HUMAN PITSLRE serine/threonine-prote... 66 7e-11 gi|27923858|sp|Q8TDR2|STK35_HUMAN Serine/threonine-protein kinas... 65 1e-10 gi|2499599|sp|Q13164|MK07_HUMAN Mitogen-activated protein kinase... 65 1e-10 gi|3913590|sp|Q15303|ERBB4_HUMAN Receptor tyrosine-protein kinas... 65 2e-10 gi|50403742|sp|P41279|M3K8_HUMAN Mitogen-activated protein kinas... 65 2e-10 gi|41017258|sp|Q9UQ07|MOK_HUMAN MAPK/MAK/MRK overlapping kinase ... 65 2e-10 gi|13432140|sp|P22455|FGFR4_HUMAN Fibroblast growth factor recep... 65 2e-10 gi|34978359|sp|P21127|CD2L1_HUMAN PITSLRE serine/threonine-prote... 65 2e-10 gi|6226784|sp|Q15131|CDK10_HUMAN Cell division protein kinase 10... 64 3e-10 gi|1709088|sp|P52564|MP2K6_HUMAN Dual specificity mitogen-activa... 64 3e-10 gi|13878706|sp|Q01974|ROR2_HUMAN Tyrosine-protein kinase transme... 64 4e-10 gi|119533|sp|P04626|ERBB2_HUMAN Receptor tyrosine-protein kinase... 64 4e-10 gi|547807|sp|P07949|RET_HUMAN Proto-oncogene tyrosine-protein ki... 64 5e-10 gi|1169123|sp|P42679|MATK_HUMAN Megakaryocyte-associated tyrosin... 64 5e-10 gi|729008|sp|Q08345|DDR1_HUMAN Epithelial discoidin domain recep... 64 5e-10 gi|29427916|sp|Q92918|M4K1_HUMAN Mitogen-activated protein kinas... 64 5e-10 gi|60391728|sp|Q6Q788|APOA5_HUMAN Apolipoprotein A-V precursor (... 63 8e-10 gi|37999491|sp|Q07912|ACK1_HUMAN Activated CDC42 kinase 1 (ACK-1) 63 8e-10 gi|2497564|sp|Q16832|DDR2_HUMAN Discoidin domain receptor 2 prec... 62 1e-09 gi|1717829|sp|Q06418|TYRO3_HUMAN Tyrosine-protein kinase recepto... 62 1e-09 gi|14285588|sp|Q99558|M3K14_HUMAN Mitogen-activated protein kina... 61 2e-09 gi|2811086|sp|P00533|EGFR_HUMAN Epidermal growth factor receptor... 61 3e-09 gi|125266|sp|P19784|CSK22_HUMAN Casein kinase II, alpha' chain (... 61 3e-09 gi|2851601|sp|P04629|NTRK1_HUMAN High affinity nerve growth fact... 61 3e-09 gi|9296963|sp|Q9Y463|DYR1B_HUMAN Dual-specificity tyrosine-phosp... 60 4e-09 gi|125060|sp|P23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Jan... 60 5e-09 gi|464868|sp|Q02763|TIE2_HUMAN Angiopoietin 1 receptor precursor... 60 7e-09 gi|51315812|sp|O75460|ERN1_HUMAN Serine/threonine protein kinase... 60 7e-09 gi|59896668|sp|Q13470|TNK1_HUMAN Non-receptor tyrosine-protein k... 60 7e-09 gi|12644000|sp|P14616|INSRR_HUMAN Insulin receptor-related prote... 59 9e-09 gi|19924290|sp|Q01973|ROR1_HUMAN Tyrosine-protein kinase transme... 59 1e-08 gi|10719883|sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinas... 59 2e-08 gi|3183003|sp|Q14289|FAK2_HUMAN Protein tyrosine kinase 2 beta (... 58 2e-08 gi|33112647|sp|P06213|INSR_HUMAN Insulin receptor precursor (IR)... 58 2e-08 gi|34222653|sp|Q9NSY1|BMP2K_HUMAN BMP-2 inducible protein kinase... 58 3e-08 gi|125527|sp|P19525|E2AK2_HUMAN Interferon-induced, double-stran... 57 4e-08 gi|20455217|sp|O43353|RIPK2_HUMAN Receptor-interacting serine/th... 57 6e-08 gi|6686295|sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinas... 55 2e-07 gi|125497|sp|P00540|MOS_HUMAN Proto-oncogene serine/threonine-pr... 55 2e-07 gi|56749062|sp|Q6VAB6|KSR2_HUMAN Kinase suppressor of ras-2 (hKSR2) 54 3e-07 gi|125484|sp|P08581|MET_HUMAN Hepatocyte growth factor receptor ... 54 3e-07 gi|18203329|sp|Q9NZJ5|E2AK3_HUMAN Eukaryotic translation initiat... 54 3e-07 gi|48429194|sp|P30530|UFO_HUMAN Tyrosine-protein kinase receptor... 54 4e-07 gi|13626405|sp|Q9NR20|DYRK4_HUMAN Dual-specificity tyrosine-phos... 54 4e-07 gi|20532386|sp|Q13705|AVR2B_HUMAN Activin receptor type IIB prec... 54 4e-07 gi|24638466|sp|P46734|MP2K3_HUMAN Dual specificity mitogen-activ... 54 5e-07 gi|13626369|sp|O43781|DYRK3_HUMAN Dual-specificity tyrosine-phos... 54 5e-07 gi|3219996|sp|Q13627|DYR1A_HUMAN Dual-specificity tyrosine-phosp... 53 6e-07 gi|124240|sp|P08069|IGF1R_HUMAN Insulin-like growth factor I rec... 53 6e-07 gi|46577677|sp|O75716|STK16_HUMAN Serine/threonine-protein kinas... 53 6e-07 gi|6919882|sp|O15197|EPHB6_HUMAN Ephrin type-B receptor 6 precur... 53 8e-07 gi|8134650|sp|Q13308|PTK7_HUMAN Tyrosine-protein kinase-like 7 p... 53 8e-07 gi|56749095|sp|Q8IVT5|KSR1_HUMAN Kinase suppressor of ras-1 (Kin... 53 8e-07 gi|13626380|sp|Q92630|DYRK2_HUMAN Dual-specificity tyrosine-phos... 52 1e-06 gi|34395641|sp|Q86Z02|HIPK1_HUMAN Homeodomain-interacting protei... 52 1e-06 gi|585912|sp|Q04912|RON_HUMAN Macrophage-stimulating protein rec... 52 2e-06 gi|50400806|sp|O15146|MUSK_HUMAN Muscle, skeletal receptor tyros... 52 2e-06 gi|114722|sp|P27037|ACVR2_HUMAN Activin receptor type II precurs... 51 3e-06 gi|125361|sp|P17948|VGFR1_HUMAN Vascular endothelial growth fact... 51 3e-06 gi|21431782|sp|Q9H2X6|HIPK2_HUMAN Homeodomain-interacting protei... 51 3e-06 gi|547778|sp|P36894|BMR1A_HUMAN Bone morphogenetic protein recep... 50 5e-06 gi|1351419|sp|P30291|WEE1_HUMAN Wee1-like protein kinase (WEE1hu) 50 7e-06 gi|1718189|sp|P35916|VGFR3_HUMAN Vascular endothelial growth fac... 50 7e-06 gi|10720097|sp|Q12866|MERTK_HUMAN Proto-oncogene tyrosine-protei... 49 9e-06 gi|9087218|sp|P35968|VGFR2_HUMAN Vascular endothelial growth fac... 49 1e-05 gi|2506798|sp|P08922|ROS_HUMAN Proto-oncogene tyrosine-protein k... 49 1e-05 gi|1706243|sp|P51841|GUC2F_HUMAN Retinal guanylyl cyclase 2 prec... 49 2e-05 gi|544320|sp|P36888|FLT3_HUMAN FL cytokine receptor precursor (T... 49 2e-05 gi|51315898|sp|Q76MJ5|ERN2_HUMAN Serine/threonine protein kinase... 48 3e-05 gi|20137251|sp|Q9UM73|ALK_HUMAN ALK tyrosine kinase receptor pre... 47 6e-05 gi|125472|sp|P10721|KIT_HUMAN Mast/stem cell growth factor recep... 46 8e-05 gi|1705918|sp|P49759|CLK1_HUMAN Dual specificity protein kinase ... 46 8e-05 gi|113916|sp|P20594|ANPB_HUMAN Atrial natriuretic peptide recept... 46 8e-05 gi|114039|sp|P02649|APOE_HUMAN Apolipoprotein E precursor (Apo-E) 45 1e-04 gi|462447|sp|Q04771|ACVR1_HUMAN Activin receptor type I precurso... 45 1e-04 gi|586086|sp|P37173|TGFR2_HUMAN TGF-beta receptor type II precur... 45 1e-04 gi|12230224|sp|O43187|IRA2_HUMAN Interleukin-1 receptor-associat... 45 2e-04 gi|24211880|sp|Q8TAS1|UHMK1_HUMAN Serine/threonine-protein kinas... 45 2e-04 gi|113912|sp|P16066|ANPA_HUMAN Atrial natriuretic peptide recept... 45 2e-04 gi|3915750|sp|P37023|ACVL1_HUMAN Serine/threonine-protein kinase... 45 2e-04 gi|1170674|sp|P29376|LTK_HUMAN Leukocyte tyrosine kinase recepto... 44 4e-04 gi|1345920|sp|Q02846|GUC2D_HUMAN Retinal guanylyl cyclase 1 prec... 44 5e-04 gi|129892|sp|P16234|PGFRA_HUMAN Alpha platelet-derived growth fa... 44 5e-04 gi|1346369|sp|P49674|KC1E_HUMAN Casein kinase I, epsilon isoform... 44 5e-04 gi|27923980|sp|P48730|KC1D_HUMAN Casein kinase I, delta isoform ... 44 5e-04 gi|18202957|sp|Q9HCP0|KC1G1_HUMAN Casein kinase I, gamma 1 isofo... 43 7e-04 gi|47117932|sp|Q9Y6M4|KC1G3_HUMAN Casein kinase I, gamma 3 isofo... 43 7e-04 gi|34922132|sp|Q9HAZ1|CLK4_HUMAN Dual specificity protein kinase... 43 9e-04 gi|129890|sp|P09619|PGFRB_HUMAN Beta platelet-derived growth fac... 42 0.001 gi|55584013|sp|Q9Y616|IRAK3_HUMAN Interleukin-1 receptor-associa... 42 0.001 gi|6226778|sp|O00238|BMR1B_HUMAN Bone morphogenetic protein rece... 42 0.001 gi|1705919|sp|P49760|CLK2_HUMAN Dual specificity protein kinase ... 42 0.002 gi|547775|sp|P36896|ACV1B_HUMAN Serine/threonine-protein kinase ... 41 0.003 gi|3024060|sp|P78368|KC1G2_HUMAN Casein kinase I, gamma 2 isofor... 40 0.004 gi|1169540|sp|P42566|EP15_HUMAN Epidermal growth factor receptor... 40 0.004 gi|123682|sp|P25092|HSER_HUMAN Heat-stable enterotoxin receptor ... 40 0.004 gi|20141240|sp|P49761|CLK3_HUMAN Dual specificity protein kinase... 40 0.004 gi|34222508|sp|Q15075|EEA1_HUMAN Early endosome antigen 1 (Endos... 40 0.007 gi|547777|sp|P36897|TGFR1_HUMAN TGF-beta receptor type I precurs... 40 0.007 gi|547770|sp|P07333|CSF1R_HUMAN Macrophage colony stimulating fa... 39 0.010 gi|12643724|sp|Q13873|BMPR2_HUMAN Bone morphogenetic protein rec... 39 0.013 gi|59800398|sp|Q96KB5|TOPK_HUMAN T-lymphokine-activated killer c... 39 0.013 gi|23822112|sp|Q9P2E9|RRB1_HUMAN Ribosome-binding protein 1 (Rib... 39 0.016 gi|21264536|sp|P45379|TNNT2_HUMAN Troponin T, cardiac muscle iso... 39 0.016 gi|47115790|sp|Q8BK63|KC1A_MOUSE Casein kinase I, alpha isoform ... 38 0.021 gi|9973397|sp|Q13418|ILK1_HUMAN Integrin-linked protein kinase 1... 38 0.021 gi|9973390|sp|P57043|ILK2_HUMAN Integrin-linked protein kinase 2... 38 0.028 gi|20178343|sp|Q14141|SEPT6_HUMAN Septin 6 37 0.036 gi|547966|sp|P12883|MYH7_HUMAN Myosin heavy chain, cardiac muscl... 37 0.036 gi|417216|sp|P33176|KINH_HUMAN Kinesin heavy chain (Ubiquitous k... 37 0.062 gi|8928535|sp|P51617|IRAK1_HUMAN Interleukin-1 receptor-associat... 36 0.081 gi|14194461|sp|Q99996|AKAP9_HUMAN A-kinase anchor protein 9 (Pro... 36 0.081 gi|1710811|sp|P34925|RYK_HUMAN Tyrosine-protein kinase RYK precu... 36 0.081 gi|1709851|sp|P23246|SFPQ_HUMAN Splicing factor, proline-and glu... 36 0.11 gi|17375490|sp|Q14203|DYNA_HUMAN Dynactin 1 (150 kDa dynein-asso... 36 0.11 gi|33518637|sp|P45378|TNNT3_HUMAN Troponin T, fast skeletal musc... 36 0.11 gi|1346640|sp|P35580|MYH10_HUMAN Myosin heavy chain, nonmuscle t... 35 0.14 gi|1174800|sp|P13805|TNNT1_HUMAN Troponin T, slow skeletal muscl... 35 0.14 gi|8134814|sp|Q9UPW0|FOXJ3_HUMAN Forkhead box protein J3 35 0.14 gi|33301318|sp|Q92614|MY18A_HUMAN Myosin XVIIIA (Myosin 18A) (My... 35 0.18 gi|20455324|sp|Q9H2D6|TARA_HUMAN TRIO and F-actin binding protei... 35 0.18 gi|586120|sp|Q07283|TRHY_HUMAN Trichohyalin 35 0.18 gi|45593722|sp|Q86Y07|VRK2_HUMAN Serine/threonine-protein kinase... 35 0.18 gi|47115840|sp|Q8N752|KC1AL_HUMAN Casein kinase I, alpha-like is... 35 0.18 gi|1346343|sp|P04264|K2C1_HUMAN Keratin, type II cytoskeletal 1 ... 35 0.18 gi|50403702|sp|O95613|PCNT2_HUMAN Pericentrin 2 (Pericentrin B) ... 35 0.18 gi|48428484|sp|Q9BXM7|PINK1_HUMAN Serine/threonine kinase PINK1,... 35 0.24 gi|30580351|sp|Q8NHQ8|CL02_HUMAN Protein C12orf2 (Carcinoma asso... 35 0.24 gi|12643957|sp|Q9Y618|NCOR2_HUMAN Nuclear receptor corepressor 2... 35 0.24 gi|21759000|sp|Q12955|ANK3_HUMAN Ankyrin 3 (ANK-3) (Ankyrin G) 34 0.31 gi|2493434|sp|Q01082|SPCO_HUMAN Spectrin beta chain, brain 1 (Sp... 34 0.31 gi|41688595|sp|Q9UJC3|HOOK1_HUMAN Hook homolog 1 (h-hook1) (hHK1) 34 0.40 gi|25009466|sp|Q9UIF3|TEK2_HUMAN Tektin-2 (Testicular tektin) (T... 34 0.40 gi|32469766|sp|Q92805|GOA1_HUMAN Golgi autoantigen, golgin subfa... 34 0.40 gi|23831094|sp|O00291|HIP1_HUMAN Huntingtin interacting protein ... 34 0.40 gi|118685|sp|P11532|DMD_HUMAN Dystrophin 34 0.40 gi|17372543|sp|Q12934|BFS1_HUMAN Filensin (Beaded filament struc... 33 0.53 gi|1730008|sp|P53804|TTC3_HUMAN Tetratricopeptide repeat protein... 33 0.53 gi|417031|sp|P32455|GBP1_HUMAN Interferon-induced guanylate-bind... 33 0.53 gi|30912698|sp|Q8NB25|CF60_HUMAN Hypothetical protein C6orf60 33 0.53 gi|47606000|sp|Q15276|RAP1_HUMAN Rab GTPase binding effector pro... 33 0.69 gi|12643718|sp|Q13439|GOA4_HUMAN Golgi autoantigen, golgin subfa... 33 0.69 gi|14195007|sp|Q15149|PLE1_HUMAN Plectin 1 (PLTN) (PCN) (Hemides... 33 0.69 gi|50401687|sp|Q9NVA2|SEP11_HUMAN Septin 11 33 0.90 gi|28201804|sp|Q14789|GOGB1_HUMAN Golgi autoantigen, golgin subf... 33 0.90 gi|12643528|sp|O00311|CDC7_HUMAN Cell division cycle 7-related p... 33 0.90 gi|56405385|sp|Q9HCM9|TM39_HUMAN Tripartite motif protein 39 (RI... 33 0.90 gi|547754|sp|P35908|K22E_HUMAN Keratin, type II cytoskeletal 2 e... 33 0.90 gi|28201884|sp|P78424|PO6F2_HUMAN POU domain, class 6, transcrip... 33 0.90 gi|3041707|sp|P13535|MYH8_HUMAN Myosin heavy chain, skeletal mus... 32 1.2 gi|20138952|sp|Q15025|NAF1_HUMAN Nef-associated factor 1 (Naf1) ... 32 1.2 gi|266902|sp|P30622|REST_HUMAN Restin (Cytoplasmic linker protei... 32 1.2 gi|133326|sp|P24928|RPB1_HUMAN DNA-directed RNA polymerase II la... 32 1.2 gi|14548191|sp|O15162|PLS1_HUMAN Phospholipid scramblase 1 (PL s... 32 1.2 gi|1709078|sp|P50221|MEOX1_HUMAN Homeobox protein MOX-1 (Mesench... 32 1.2 gi|1346682|sp|P48681|NEST_HUMAN Nestin 32 1.2 gi|20532393|sp|O15230|LMA5_HUMAN Laminin alpha-5 chain precursor 32 1.2 gi|29337005|sp|Q9UQE7|SMC3_HUMAN Structural maintenance of chrom... 32 1.5 gi|23503070|sp|Q06547|GABP2_HUMAN GA binding protein beta chain ... 32 1.5 gi|56405387|sp|Q9UPN3|MACF1_HUMAN Microtubule-actin crosslinking... 32 1.5 gi|44887869|sp|Q96EP5|DAZP1_HUMAN DAZ-associated protein 1 (Dele... 32 1.5 gi|30316105|sp|Q96PK2|MAC4_HUMAN Microtubule-actin crosslinking ... 32 1.5 gi|41688571|sp|Q13477|MACA_HUMAN Mucosal addressin cell adhesion... 32 1.5 gi|48474671|sp|Q9NSB2|K2H4_HUMAN Keratin, type II cuticular HB4 ... 32 1.5 gi|6136547|sp|O60299|Y552_HUMAN Hypothetical protein KIAA0552 32 2.0 gi|23396633|sp|Q15058|KF14_HUMAN Kinesin-like protein KIF14 32 2.0 gi|32470610|sp|Q08378|GOA3_HUMAN Golgi autoantigen, golgin subfa... 32 2.0 gi|1350802|sp|Q05823|RN5A_HUMAN 2-5A-dependent ribonuclease (2-5... 32 2.0 gi|29429203|sp|P54259|DRPLA_HUMAN Atrophin-1 (Dentatorubral-pall... 32 2.0 gi|60392986|sp|Q92878|RAD50_HUMAN DNA repair protein RAD50 (hRAD50) 31 2.6 gi|132518|sp|P22670|RFX1_HUMAN MHC class II regulatory factor RF... 31 2.6 gi|2495730|sp|Q92558|WAS1_HUMAN Wiskott-Aldrich syndrome protein... 31 2.6 gi|59800455|sp|Q9UPY6|WASF3_HUMAN Wiskott-Aldrich syndrome prote... 31 2.6 gi|2506877|sp|Q02817|MUC2_HUMAN Mucin 2 precursor (Intestinal mu... 31 2.6 gi|26392452|sp|Q9BQ89|CT55_HUMAN Protein C20orf55 31 2.6 gi|2498313|sp|Q16643|DREB_HUMAN Drebrin (Developmentally regulat... 31 2.6 gi|3913957|sp|O14782|KF3C_HUMAN Kinesin-like protein KIF3C 31 2.6 gi|52000729|sp|Q8WWM7|ATXL_HUMAN Ataxin-2-like protein (Ataxin-2... 31 2.6 gi|17367904|sp|O15020|SPCP_HUMAN Spectrin beta chain, brain 2 (S... 31 2.6 gi|32129445|sp|Q96SN8|C5P2_HUMAN CDK5 regulatory subunit associa... 31 2.6 gi|13124568|sp|Q9UPE1|STK23_HUMAN Serine/threonine-protein kinas... 31 3.4 gi|25008939|sp|O75626|PRDM1_HUMAN PR-domain zinc finger protein ... 31 3.4 gi|9087133|sp|Q16671|AMHR2_HUMAN Anti-Muellerian hormone type II... 31 3.4 gi|17373489|sp|Q13111|CAF1A_HUMAN Chromatin assembly factor 1 su... 31 3.4 gi|54035738|sp|Q9Y2D8|ADIP_HUMAN Afadin- and alpha-actinin-bindi... 31 3.4 gi|400793|sp|Q00722|PIB2_HUMAN 1-phosphatidylinositol-4,5-bispho... 31 3.4 gi|55976299|sp|Q14134|TM29_HUMAN Tripartite motif protein 29 (At... 31 3.4 gi|1709217|sp|P49792|RBP2_HUMAN Ran-binding protein 2 (RanBP2) (... 31 3.4 gi|42558969|sp|Q13136|LPA1_HUMAN Liprin-alpha 1 (Protein tyrosin... 31 3.4 gi|14194715|sp|Q92817|EVPL_HUMAN Envoplakin (210 kDa paraneoplas... 31 3.4 gi|50401165|sp|Q9H3R2|MU13_HUMAN Mucin 13 precursor (Down-regula... 31 3.4 gi|32469788|sp|Q9NYA3|GOA6_HUMAN Golgi autoantigen, golgin subfa... 31 3.4 gi|12643326|sp|Q9ULV3|CIZ1_HUMAN Cip1-interacting zinc finger pr... 31 3.4 gi|22653665|sp|Q9NRL2|BAZ1A_HUMAN Bromodomain adjacent to zinc f... 31 3.4 gi|13959694|sp|O95239|KF4A_HUMAN Chromosome-associated kinesin K... 31 3.4 gi|29839588|sp|Q8WXH0|SNE2_HUMAN Nesprin 2 (Nuclear envelope spe... 31 3.4 gi|12643319|sp|O75665|OFD1_HUMAN Oral-facial-digital syndrome 1 ... 30 4.5 gi|34098413|sp|Q15311|RBP1_HUMAN RalA binding protein 1 (RalBP1)... 30 4.5 gi|1345731|sp|P49454|CENPF_HUMAN CENP-F kinetochore protein (Cen... 30 4.5 gi|45593726|sp|Q99986|VRK1_HUMAN Serine/threonine-protein kinase... 30 4.5 gi|544357|sp|P35637|FUS_HUMAN RNA-binding protein FUS (Oncogene ... 30 4.5 gi|51701377|sp|O15083|ERC2_HUMAN ERC protein 2 30 4.5 gi|3023440|sp|Q92793|CBP_HUMAN CREB-binding protein 30 4.5 gi|13432177|sp|P35749|MYH11_HUMAN Myosin heavy chain, smooth mus... 30 4.5 gi|6166599|sp|P35579|MYH9_HUMAN Myosin heavy chain, nonmuscle ty... 30 4.5 gi|17366354|sp|P58397|ATS12_HUMAN ADAMTS-12 precursor (A disinte... 30 4.5 gi|51827892|sp|Q8IUD2|ERC1_HUMAN ERC protein 1 (ELKS protein) 30 4.5 gi|20454925|sp|Q96RT7|GCP6_HUMAN Gamma-tubulin complex component... 30 4.5 gi|33112673|sp|Q9Y496|KF3A_HUMAN Kinesin-like protein KIF3A (Mic... 30 4.5 gi|25452905|sp|Q9H501|CT06_HUMAN Hypothetical protein C20orf6 30 5.8 gi|731165|sp|Q02040|XE7_HUMAN B-lymphocyte antigen precursor (B-... 30 5.8 gi|2498204|sp|Q05682|CALD1_HUMAN Caldesmon (CDM) 30 5.8 gi|18202959|sp|Q9HCU9|BRMS1_HUMAN Breast cancer metastasis-suppr... 30 5.8 gi|14916998|sp|P00390|GSHR_HUMAN Glutathione reductase, mitochon... 30 5.8 gi|1169868|sp|P32456|GBP2_HUMAN Interferon-induced guanylate-bin... 30 5.8 gi|30580364|sp|Q9BV73|CEP2_HUMAN Centrosomal protein 2 (Centroso... 30 5.8 gi|23503097|sp|P57071|PRD15_HUMAN PR-domain zinc finger protein ... 30 5.8 gi|134798|sp|P11277|SPTB1_HUMAN Spectrin beta chain, erythrocyte... 30 5.8 gi|57015374|sp|P49750|YLPM1_HUMAN YLP motif containing protein 1... 30 5.8 gi|51338794|sp|P78559|MAP1A_HUMAN Microtubule-associated protein... 30 5.8 gi|14195666|sp|O60841|IF2P_HUMAN Eukaryotic translation initiati... 30 5.8 gi|2833266|sp|Q15696|U2R2_HUMAN U2 small nuclear ribonucleoprote... 30 7.6 gi|6919871|sp|O14641|DVL2_HUMAN Segment polarity protein disheve... 30 7.6 gi|38258418|sp|Q15637|SF01_HUMAN Splicing factor 1 (Zinc finger ... 30 7.6 gi|6175080|sp|P78423|X3CL1_HUMAN Fractalkine precursor (CX3CL1) ... 30 7.6 gi|38372394|sp|Q9NUV9|GIM4_HUMAN GTPase, IMAP family member 4 (I... 30 7.6 gi|55583953|sp|Q8N3L3|TAXB_HUMAN Beta-taxilin (Muscle derived pr... 30 7.6 gi|3024341|sp|Q09472|EP300_HUMAN E1A-associated protein p300 30 7.6 gi|8134347|sp|O43683|BUB1_HUMAN Mitotic checkpoint serine/threon... 30 7.6 gi|1730009|sp|P12270|TPR_HUMAN Nucleoprotein TPR 30 7.6 gi|20139283|sp|Q9UL16|NESG_HUMAN Nasopharyngeal epithelium speci... 30 7.6 gi|50403738|sp|P35125|UBP6_HUMAN Ubiquitin carboxyl-terminal hyd... 30 7.6 gi|6226826|sp|O75330|HMMR_HUMAN Hyaluronan mediated motility rec... 30 7.6 gi|41017595|sp|O95153|RIP1_HUMAN Peripheral-type benzodiazepine ... 30 7.6 gi|33302627|sp|Q15643|TRIPB_HUMAN Thyroid receptor interacting p... 30 7.6 gi|45645200|sp|Q92599|SEP8_HUMAN Septin 8 30 7.6 gi|27923958|sp|O94833|BPAEA_HUMAN Bullous pemphigoid antigen 1, ... 30 7.6 gi|41019546|sp|Q9D032|SSBP3_MOUSE Single-stranded DNA-binding pr... 29 9.9 gi|55976496|sp|Q7Z4K8|TM46_HUMAN Tripartite motif protein 46 (Tr... 29 9.9 ALIGNMENTS >gi|113992|sp|P02647|APOA1_HUMAN Apolipoprotein A-I precursor (Apo-AI) (ApoA-I) Length = 267 Score = 475 bits (1223), Expect = e-134 Identities = 240/267 (89%), Positives = 240/267 (89%) Query: 1081 MKXXXXXXXXXXXXGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 1140 MK GSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS Sbjct: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 60 Query: 1141 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 1200 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK Sbjct: 61 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 120 Query: 1201 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 1260 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV Sbjct: 121 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 180 Query: 1261 DALRTHLAPYSDXXXXXXXXXXXXXXXNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 1320 DALRTHLAPYSD NGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ Sbjct: 181 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 240 Query: 1321 GLLPVLESFKVSFLSALEEYTKKLNTQ 1347 GLLPVLESFKVSFLSALEEYTKKLNTQ Sbjct: 241 GLLPVLESFKVSFLSALEEYTKKLNTQ 267 >gi|59798973|sp|Q9H0K1|SN1L2_HUMAN Serine/threonine-protein kinase SNF1-like kinase 2 (Qin-induced kinase) Length = 926 Score = 363 bits (932), Expect = e-100 Identities = 183/296 (61%), Positives = 223/296 (75%), Gaps = 21/296 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 TK VAIKIIDK+QLD NL+KI+REVQIMKML HPHII+LYQVMET+ M+YLVTEYA Sbjct: 42 TKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKN 101 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GEIFD+L HGR+ E EARRKF QI++AV +CH R IVHRDLKAENLLLD N+NIKIADF Sbjct: 102 GEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADF 161 Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195 GF N F G+LL TWCGSPPYAAPE+FEG++Y+GP++DIWS+GVVLYVLVCGALPFDG T Sbjct: 162 GFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPT 221 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255 L LR RVL G+FRIP+FMS +CEHLIR MLVLDP+KRL++ Sbjct: 222 LPILRQRVLEGRFRIPYFMS------------------EDCEHLIRRMLVLDPSKRLTIA 263 Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQ 311 QI +HKWM + + R + Q+ + E + NE VL M +G+D+++T++ Sbjct: 264 QIKEHKWMLI---EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316 >gi|59803093|sp|P57059|SN1L1_HUMAN Serine/threonine-protein kinase SNF1-like kinase 1 (Serine/threonine-protein kinase SNF1LK) Length = 783 Score = 330 bits (847), Expect = 2e-90 Identities = 164/299 (54%), Positives = 214/299 (71%), Gaps = 26/299 (8%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 TK VAIKIIDKT+LD NL+KI+REVQ+MK+L HPHII+LYQVMET+ M+Y+VTE+A Sbjct: 49 TKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKN 108 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GE+FD+L ++G ++E EAR+KF QI++AV +CH +IVHRDLK ENLLLD N++IK+ADF Sbjct: 109 GEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADF 168 Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195 GF N + G+ L TWCGSPPYAAPE+FEGKEY+GP++DIWSLGVVLYVLVCG+LPFDG Sbjct: 169 GFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPN 228 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255 L LR RVL G+FRIPFFMS +CE LIR MLV+DP +R+++ Sbjct: 229 LPTLRQRVLEGRFRIPFFMS------------------QDCESLIRRMLVVDPARRITIA 270 Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPL---NEDVLLAMEDMGLDKEQTLQ 311 QI +H+WM+ P C L +E L M+ +G+D+++T++ Sbjct: 271 QIRQHRWMRAEPCLPG-----PACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVE 324 >gi|29840797|sp|Q96L34|MARK4_HUMAN MAP/microtubule affinity-regulating kinase 4 (MAP/microtubule affinity-regulating kinase like 1) Length = 752 Score = 325 bits (834), Expect = 5e-89 Identities = 159/251 (63%), Positives = 199/251 (79%), Gaps = 18/251 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T + VAIKIIDKTQL+ +L+K+FREV+IMK L HP+I++L++V+ETE+ +YLV EYAS Sbjct: 81 TGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASA 140 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GE+FD+LV+HGRM EKEAR KF+QIV+AV++CH +NIVHRDLKAENLLLDA NIKIADF Sbjct: 141 GEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF 200 Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195 GFSN FT G L T+CGSPPYAAPELF+GK+YDGP+VDIWSLGV+LY LV G+LPFDG Sbjct: 201 GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHN 260 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255 L+ LR RVL GK+R+PF+MST +CE ++R LVL+P KR ++E Sbjct: 261 LKELRERVLRGKYRVPFYMST------------------DCESILRRFLVLNPAKRCTLE 302 Query: 256 QICKHKWMKLG 266 QI K KW+ +G Sbjct: 303 QIMKDKWINIG 313 >gi|29337165|sp|P27448|MARK3_HUMAN MAP/microtubule affinity-regulating kinase 3 (Cdc25C-associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10) Length = 776 Score = 315 bits (806), Expect = 9e-86 Identities = 159/297 (53%), Positives = 210/297 (70%), Gaps = 41/297 (13%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T + VAIKIIDKTQL+ +L+K+FREV+IMK+L HP+I++L++V+ETE+ +YL+ EYASG Sbjct: 78 TGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASG 137 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQ-----------------------IVTAVYFCHCRNI 112 GE+FD+LVAHGRM EKEAR KF+Q IV+AV +CH + I Sbjct: 138 GEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRI 197 Query: 113 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 172 VHRDLKAENLLLDA++NIKIADFGFSN FT G L T+CGSPPYAAPELF+GK+YDGP+V Sbjct: 198 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 257 Query: 173 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLS 232 D+WSLGV+LY LV G+LPFDG L+ LR RVL GK+RIPF+MST Sbjct: 258 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMST---------------- 301 Query: 233 IAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVD 289 +CE+L++ LVL+P KR ++EQI K +W+ G + + + +++++D Sbjct: 302 --DCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID 356 >gi|34395849|sp|Q8IWQ3|BRSK2_HUMAN BR serine/threonine-protein kinase 2 (Serine/threonine-protein kinase 29) (HUSSY-12) Length = 736 Score = 244 bits (623), Expect = 2e-64 Identities = 129/324 (39%), Positives = 197/324 (60%), Gaps = 24/324 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T Q VAIKI+++ +L E L K+ RE+ I+K++ HPH+++L+ V E ++ +YLV E+ SG Sbjct: 41 TCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSG 100 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GE+FD+LV GR+ KEAR+ F+QI++A+ FCH +I HRDLK ENLLLD NI+IADF Sbjct: 101 GELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADF 160 Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195 G ++L LL+T CGSP YA PE+ G++YDG K D+WS GV+L+ L+ GALPFD Sbjct: 161 GMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDN 220 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255 L+ L +V G F +P F+ +C+ L+R M +D +RL++E Sbjct: 221 LRQLLEKVKRGVFHMPHFIP------------------PDCQSLLRGMSEVDAARRLTLE 262 Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQPDGT 315 I KH W G +P ++ I Q++ ++ ++ DVL +M +G +++ Sbjct: 263 HIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDL 322 Query: 316 LNLDSDEGEEPSPEALVRYLSMRR 339 L+ EE + E ++ +L + R Sbjct: 323 LS------EEENQEKMIYFLLLDR 340 >gi|34395684|sp|Q8TDC3|KI11_HUMAN Probable serine/threonine-protein kinase KIAA1811 Length = 794 Score = 243 bits (619), Expect = 4e-64 Identities = 134/328 (40%), Positives = 197/328 (60%), Gaps = 30/328 (9%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T Q VAIKI+++ +L E L K+ RE+ I+K++ HPH+++L+ V E ++ +YLV E+ SG Sbjct: 72 TGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSG 131 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GE+FD+LV GR+ KEAR+ F+QIV+A+ FCH +I HRDLK ENLLLD NI+IADF Sbjct: 132 GELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADF 191 Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195 G ++L LL+T CGSP YA PE+ +G++YDG + D+WS GV+L+ L+ GALPFD Sbjct: 192 GMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDN 251 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255 L+ L +V G F +P F+ +C+ L+R M+ ++P KRLS+E Sbjct: 252 LRQLLEKVKRGVFHMPHFIP------------------PDCQSLLRGMIEVEPEKRLSLE 293 Query: 256 QICKHKWMKLG--DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL--DKEQTLQ 311 QI KH W G + DP + ++ L+ DVL +M +G D+E+ + Sbjct: 294 QIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHR 353 Query: 312 PDGTLNLDSDEGEEPSPEALVRYLSMRR 339 EE + E ++ YL + R Sbjct: 354 --------ELRSEEENQEKMIYYLLLDR 373 >gi|20178276|sp|P54646|AAPK2_HUMAN 5'-AMP-activated protein kinase, catalytic alpha-2 chain (AMPK alpha-2 chain) Length = 552 Score = 238 bits (608), Expect = 8e-63 Identities = 122/278 (43%), Positives = 178/278 (64%), Gaps = 25/278 (8%) Query: 14 QETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 Q T VA+KI+++ ++ + + KI RE+Q +K+ HPHII+LYQV+ T ++V EY Sbjct: 36 QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEY 95 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 SGGE+FD++ HGR+ E EARR F+QI++AV +CH +VHRDLK EN+LLDA++N KI Sbjct: 96 VSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKI 155 Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 ADFG SN+ + G+ L+T CGSP YAAPE+ G+ Y GP+VDIWS GV+LY L+CG LPFD Sbjct: 156 ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 + L ++ G F IP +++ + L+ HML +DP KR Sbjct: 216 DEHVPTLFKKIRGGVFYIPEYLNRSVAT------------------LLMHMLQVDPLKRA 257 Query: 253 SMEQICKHKWMK------LGDADPNFDRLIAECQQLKE 284 +++ I +H+W K L DP++D + + + +KE Sbjct: 258 TIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKE 295 >gi|20178277|sp|Q13131|AAPK1_HUMAN 5'-AMP-activated protein kinase, catalytic alpha-1 chain (AMPK alpha-1 chain) Length = 550 Score = 238 bits (606), Expect = 1e-62 Identities = 142/376 (37%), Positives = 211/376 (56%), Gaps = 54/376 (14%) Query: 16 TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T VA+KI+++ ++ + + KI RE+Q +K+ HPHII+LYQV+ T I++V EY S Sbjct: 40 TGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVS 99 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GGE+FD++ +GR+ EKE+RR F+QI++ V +CH +VHRDLK EN+LLDA++N KIAD Sbjct: 100 GGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIAD 159 Query: 135 FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194 FG SN+ + G+ L+T CGSP YAAPE+ G+ Y GP+VDIWS GV+LY L+CG LPFD Sbjct: 160 FGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDD 219 Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSM 254 + L ++ G F P +++ ++ L++HML +DP KR S+ Sbjct: 220 HVPTLFKKICDGIFYTPQYLNPSVI------------------SLLKHMLQVDPMKRASI 261 Query: 255 EQICKHKWMK------LGDADPNFDRLIAECQQLKE--------ERQV----------DP 290 + I +H+W K L DP++ + + + LKE E +V DP Sbjct: 262 KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDP 321 Query: 291 LNEDVLLAMEDMGLDKE------QTLQPDGTLNLDSDEGEEPSPEA---LVRYLSMRRHT 341 L L +++ + E T PD LD P PE LV RHT Sbjct: 322 LAVAYHLIIDNRRIMNEAKDFYLATSPPDSF--LDDHHLTRPHPERVPFLVAETPRARHT 379 Query: 342 VGVADPRTEVMEDLQK 357 + +P+ + ++K Sbjct: 380 LDELNPQKSKHQGVRK 395 >gi|14424095|sp|O60285|ARK5_HUMAN AMPK-related protein kinase 5 Length = 661 Score = 224 bits (570), Expect = 2e-58 Identities = 114/268 (42%), Positives = 171/268 (63%), Gaps = 25/268 (9%) Query: 18 QLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 ++VAIK I K ++ DE+++ I RE++IM L HPHII +Y+V E + I ++ EYAS G Sbjct: 79 RVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKG 138 Query: 77 EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136 E++D++ R++E+E R F+QIV+AV++CH +VHRDLK EN+LLD N NIKIADFG Sbjct: 139 ELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFG 198 Query: 137 FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196 SNL+ + L+T+CGSP YA+PE+ G+ Y GP+VD W+LGV+LY LV G +PFDG Sbjct: 199 LSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDH 258 Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256 +NL ++ SG++R P ++ LIR ML+++P++R ++E Sbjct: 259 KNLIRQISSGEYREP-------------------TQPSDARGLIRWMLMVNPDRRATIED 299 Query: 257 ICKHKWMKLGDADPNFDRLIAECQQLKE 284 I H W+ G + + +C L + Sbjct: 300 IANHWWVNWG-----YKSSVCDCDALHD 322 >gi|50400857|sp|Q14680|MELK_HUMAN Maternal embryonic leucine zipper kinase (hMELK) (Protein kinase PK38) (hPK38) Length = 651 Score = 195 bits (496), Expect = 8e-50 Identities = 101/250 (40%), Positives = 151/250 (60%), Gaps = 21/250 (8%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T ++VAIKI+DK L + L +I E++ +K L H HI +LY V+ET I++V EY G Sbjct: 33 TGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPG 91 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GE+FD++++ R++E+E R F+QIV+AV + H + HRDLK ENLL D +K+ DF Sbjct: 92 GELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDF 151 Query: 136 GF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 G L+T CGS YAAPEL +GK Y G + D+WS+G++LYVL+CG LPFD Sbjct: 152 GLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDD 211 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253 + L +++ GK+ +P ++S + L++ ML +DP KR+S Sbjct: 212 DNVMALYKKIMRGKYDVPKWLSPSSI------------------LLLQQMLQVDPKKRIS 253 Query: 254 MEQICKHKWM 263 M+ + H W+ Sbjct: 254 MKNLLNHPWI 263 >gi|30316282|sp|Q9BXA7|ST22A_HUMAN Serine/threonine-protein kinase 22A (Testis-specific kinase 1) (TSK-1) (Testis-specific serine kinase 1) (TSSK-1) (Serine/threonine-protein kinase FKSG81) Length = 367 Score = 186 bits (471), Expect = 6e-47 Identities = 119/342 (34%), Positives = 183/342 (53%), Gaps = 38/342 (11%) Query: 12 FLQETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETER-MIYLV 69 + + K VAIKIID+ + + L+K RE++I+ ML H II+ Y++ ET +Y+V Sbjct: 30 YSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIV 89 Query: 70 TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 E A G++ + + G + E EAR+KF Q+ A+ +CH ++VHRDLK +NLLLD + N Sbjct: 90 MELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFN 149 Query: 130 IKIADFGFSNLFTPGQ-----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184 IK++DF FS L KT+CGSP YAAPE+ +G Y DIWSLGV+LY++ Sbjct: 150 IKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIM 209 Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244 VCG++P+D S ++ + + + R+ F S L EC+ LI HML Sbjct: 210 VCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLT--------------GECKDLIYHML 253 Query: 245 VLDPNKRLSMEQICKHKWMK-LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMG 303 D N+RL +++I H WM+ P+ +A ++ + R +P L + G Sbjct: 254 QPDVNRRLHIDEILSHCWMQPKARGSPS----VAINKEGESSRGTEP------LWTPEPG 303 Query: 304 LDKEQT--LQPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVG 343 DK+ L+P+G + E PE +S + +G Sbjct: 304 SDKKSATKLEPEGEAQPQAQ--PETKPEGTAMQMSRQSEILG 343 >gi|30316269|sp|Q96PF2|ST22B_HUMAN Serine/threonine-protein kinase 22B (Testis-specific kinase 2) (TSK-2) (Testis-specific serine kinase 2) (TSSK-2) (DiGeorge syndrome protein G) Length = 358 Score = 168 bits (426), Expect = 1e-41 Identities = 94/260 (36%), Positives = 153/260 (58%), Gaps = 23/260 (8%) Query: 12 FLQETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMET-ERMIYLV 69 + + K VA+KIID+ + + +++ RE+ I+ + H II+ Y++ ET + IY++ Sbjct: 30 YSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYII 89 Query: 70 TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 E G++ + + G + E AR+ F+Q+ +AV +CH +IVHRDLK ENLLLD + N Sbjct: 90 MELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFN 149 Query: 130 IKIADFGFSNLF---TPGQLL--KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184 IK++DFGFS + G+++ KT+CGS YAAPE+ + Y DIWSLGV+LY++ Sbjct: 150 IKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIM 209 Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244 VCG++P+D S ++ + + + R+ F S L EC+ LI ML Sbjct: 210 VCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLT--------------CECKDLIYRML 253 Query: 245 VLDPNKRLSMEQICKHKWMK 264 D ++RL +++I H W++ Sbjct: 254 QPDVSQRLHIDEILSHSWLQ 273 >gi|9973393|sp|P57058|HUNK_HUMAN Hormonally up-regulated neu tumor-associated kinase (Serine/threonine-protein kinase MAK-V) (B19) Length = 714 Score = 166 bits (421), Expect = 4e-41 Identities = 100/253 (39%), Positives = 143/253 (56%), Gaps = 21/253 (8%) Query: 16 TKQLVAIKIIDKTQLDEENL--KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 T + VAIK+IDK + ++ K + RE QI +M+ HP+I +L ++ETE YLV E Sbjct: 84 TGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELC 143 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GG + + R+ E EARR +Q+++AV H +VHRDLK ENLLLD + NIK+ Sbjct: 144 PGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLI 203 Query: 134 DFGFSN---LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 DFG SN + T CGSP YAAPEL K+Y GPK+D+WS+GV +Y ++ G LP Sbjct: 204 DFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLP 262 Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 F T++ R L K M + L +L G +S +R +L DP K Sbjct: 263 F---TVEPFSLRALYQK------MVDKEMNPLPTQLSTGAIS------FLRSLLEPDPVK 307 Query: 251 RLSMEQICKHKWM 263 R +++Q ++W+ Sbjct: 308 RPNIQQALANRWL 320 >gi|30316270|sp|Q96PN8|ST22C_HUMAN Serine/threonine-protein kinase 22C (Testis-specific kinase 3) (TSK-3) (Testis-specific serine kinase 3) (TSSK-3) Length = 268 Score = 164 bits (415), Expect = 2e-40 Identities = 93/256 (36%), Positives = 152/256 (59%), Gaps = 22/256 (8%) Query: 12 FLQETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMET-ERMIYLV 69 F ++ ++ VAIK+IDK EE +++ RE+QI++ L H +II++Y+++E+ + I LV Sbjct: 28 FSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLV 87 Query: 70 TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 E A GG++FD ++ G + E A+ F+Q+V A+ +CH + HRDLK EN LL N Sbjct: 88 MELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQG-FN 146 Query: 130 IKIADFGFSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187 +K+ DFGF+ + +L +T+CGS YAAPE+ +G +D K D+WS+GVVLYV++C Sbjct: 147 LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCA 206 Query: 188 ALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247 +LPFD + + + + G P +S A+C+ L++ +L D Sbjct: 207 SLPFDDTDIPKMLWQQQKG-VSFPTHLSIS----------------ADCQDLLKRLLEPD 249 Query: 248 PNKRLSMEQICKHKWM 263 R S+E++ H W+ Sbjct: 250 MILRPSIEEVSWHPWL 265 >gi|27805738|sp|Q9UQB9|AURKC_HUMAN Serine/threonine-protein kinase 13 (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C) Length = 309 Score = 162 bits (411), Expect = 6e-40 Identities = 92/271 (33%), Positives = 148/271 (54%), Gaps = 26/271 (9%) Query: 13 LQETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71 L+E+ +VA+K++ K+Q+++E L+ ++ RE++I L HP+I+RLY R +YL+ E Sbjct: 62 LKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILE 121 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 YA GE++ L ++ E+ +++ A+ +CH + ++HRD+K ENLLL +K Sbjct: 122 YAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVK 181 Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 IADFG+S + TP KT CG+ Y PE+ EG+ YD KVD+W +GV+ Y L+ G PF Sbjct: 182 IADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD-EKVDLWCIGVLCYELLVGYPPF 239 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 + ++ R+L R P M G LI +L P +R Sbjct: 240 ESASHSETYRRILKVDVRFPLSMPLG------------------ARDLISRLLRYQPLER 281 Query: 252 LSMEQICKHKWMKLGDADPNFDRLIAECQQL 282 L + QI KH W++ + R++ C Q+ Sbjct: 282 LPLAQILKHPWVQ-----AHSRRVLPPCAQM 307 >gi|2499586|sp|Q16566|KCC4_HUMAN Calcium/calmodulin-dependent protein kinase type IV (CAM kinase-GR) (CaMK IV) Length = 473 Score = 160 bits (404), Expect = 4e-39 Identities = 102/253 (40%), Positives = 153/253 (60%), Gaps = 25/253 (9%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T++ A+K++ KT +D KKI R E+ ++ L HP+II+L ++ ET I LV E + Sbjct: 68 TQKPYALKVLKKT-VD----KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVT 122 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA---NLNIK 131 GGE+FD +V G +E++A KQI+ AV + H IVHRDLK ENLL + +K Sbjct: 123 GGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLK 182 Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 IADFG S + L+KT CG+P Y APE+ G Y GP+VD+WS+G++ Y+L+CG PF Sbjct: 183 IADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY-GPEVDMWSVGIITYILLCGFEPF 241 Query: 192 -DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 D Q + R+L+ ++ +F+S P D+ +S+ + L+R ++VLDP K Sbjct: 242 YDERGDQFMFRRILNCEY---YFIS----PWWDE------VSL-NAKDLVRKLIVLDPKK 287 Query: 251 RLSMEQICKHKWM 263 RL+ Q +H W+ Sbjct: 288 RLTTFQALQHPWV 300 >gi|3122301|sp|Q14012|KCC1A_HUMAN Calcium/calmodulin-dependent protein kinase type 1 (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha) Length = 370 Score = 156 bits (395), Expect = 4e-38 Identities = 95/272 (34%), Positives = 144/272 (52%), Gaps = 26/272 (9%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 + T++LVAIK I K L+ + + E+ ++ + HP+I+ L + E+ +YL+ + Sbjct: 40 KRTQKLVAIKCIAKEALEGKE-GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLV 98 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL---LDANLNI 130 SGGE+FD +V G E++A R Q++ AV + H IVHRDLK ENLL LD + I Sbjct: 99 SGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKI 158 Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 I+DFG S + PG +L T CG+P Y APE+ K Y VD WS+GV+ Y+L+CG P Sbjct: 159 MISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPP 217 Query: 191 FDGSTLQNLRARVLSGKFRI--PFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248 F L ++L ++ P++ + IRH++ DP Sbjct: 218 FYDENDAKLFEQILKAEYEFDSPYWDDIS----------------DSAKDFIRHLMEKDP 261 Query: 249 NKRLSMEQICKHKWMKLGDA--DPNFDRLIAE 278 KR + EQ +H W+ GD D N + ++E Sbjct: 262 EKRFTCEQALQHPWI-AGDTALDKNIHQSVSE 292 >gi|56404610|sp|Q8IU85|KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase type 1D (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) Length = 385 Score = 150 bits (380), Expect = 2e-36 Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 23/253 (9%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T +L A+K I K L + I E+ +++ + H +I+ L + E+ +YLV + SG Sbjct: 45 TGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSG 103 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKI 132 GE+FD +V G EK+A +Q++ AVY+ H IVHRDLK ENLL D I I Sbjct: 104 GELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMI 163 Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 +DFG S + G ++ T CG+P Y APE+ K Y VD WS+GV+ Y+L+CG PF Sbjct: 164 SDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFY 222 Query: 193 GSTLQNLRARVLSGKFRI--PFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 L ++L ++ P++ + IR+++ DPNK Sbjct: 223 DENDSKLFEQILKAEYEFDSPYWDDIS----------------DSAKDFIRNLMEKDPNK 266 Query: 251 RLSMEQICKHKWM 263 R + EQ +H W+ Sbjct: 267 RYTCEQAARHPWI 279 >gi|27923855|sp|O14965|STK6_HUMAN Serine/threonine-protein kinase 6 (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) Length = 403 Score = 149 bits (377), Expect = 5e-36 Identities = 81/259 (31%), Positives = 140/259 (54%), Gaps = 21/259 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 +++K ++A+K++ K QL++ ++ ++ REV+I L HP+I+RLY +YL+ EY Sbjct: 153 KQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEY 212 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 A G ++ L + E+ ++ A+ +CH + ++HRD+K ENLLL + +KI Sbjct: 213 APLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKI 272 Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 ADFG+S + P T CG+ Y PE+ EG+ +D KVD+WSLGV+ Y + G PF+ Sbjct: 273 ADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMHD-EKVDLWSLGVLCYEFLVGKPPFE 330 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 +T Q R+ +F P F++ G LI +L +P++R Sbjct: 331 ANTYQETYKRISRVEFTFPDFVTEG------------------ARDLISRLLKHNPSQRP 372 Query: 253 SMEQICKHKWMKLGDADPN 271 + ++ +H W+ + P+ Sbjct: 373 MLREVLEHPWITANSSKPS 391 >gi|27805737|sp|Q96GD4|AURKB_HUMAN Serine/threonine-protein kinase 12 (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2) (STK-1) (Aurora-B) Length = 344 Score = 148 bits (373), Expect = 1e-35 Identities = 81/247 (32%), Positives = 138/247 (55%), Gaps = 21/247 (8%) Query: 19 LVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 +VA+K++ K+Q+++E ++ ++ RE++I L HP+I+RLY R IYL+ EYA GE Sbjct: 102 IVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGE 161 Query: 78 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 ++ L E+ +++ A+ +CH + ++HRD+K ENLLL +KIADFG+ Sbjct: 162 LYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGW 221 Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ 197 S + P KT CG+ Y PE+ EG+ ++ KVD+W +GV+ Y L+ G PF+ ++ Sbjct: 222 S-VHAPSLRRKTMCGTLDYLPPEMIEGRMHN-EKVDLWCIGVLCYELLVGNPPFESASHN 279 Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQI 257 R++ + P + TG + K L+RH +P++RL + Q+ Sbjct: 280 ETYRRIVKVDLKFPASVPTGAQDLISK--------------LLRH----NPSERLPLAQV 321 Query: 258 CKHKWMK 264 H W++ Sbjct: 322 SAHPWVR 328 >gi|125536|sp|P15735|PHKG2_HUMAN Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2) (PSK-C3) Length = 406 Score = 146 bits (368), Expect = 6e-35 Identities = 91/256 (35%), Positives = 142/256 (55%), Gaps = 26/256 (10%) Query: 21 AIKIIDKT--QLDEENLKKIF----REVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYA 73 A+KI++ T +L E L+++ RE I++ + HPHII L E+ ++LV + Sbjct: 51 AVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLM 110 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GE+FD+L ++EKE R + ++ AV F H NIVHRDLK EN+LLD N+ I+++ Sbjct: 111 RKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLS 170 Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELF-----EGKEYDGPKVDIWSLGVVLYVLVCGA 188 DFGFS PG+ L+ CG+P Y APE+ E G +VD+W+ GV+L+ L+ G+ Sbjct: 171 DFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGS 230 Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248 PF + ++ G+++ F S PE D R + + LI +L +DP Sbjct: 231 PPFWHRRQILMLRMIMEGQYQ---FSS----PEWDDR-------SSTVKDLISRLLQVDP 276 Query: 249 NKRLSMEQICKHKWMK 264 RL+ EQ +H + + Sbjct: 277 EARLTAEQALQHPFFE 292 >gi|6685284|sp|O96017|CHK2_HUMAN Serine/threonine-protein kinase Chk2 (Cds1) Length = 543 Score = 145 bits (365), Expect = 1e-34 Identities = 93/279 (33%), Positives = 148/279 (53%), Gaps = 27/279 (9%) Query: 12 FLQETKQLVAIKIIDKTQL------DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 F ++T + VAIKII K + + + + E++I+K L HP II++ + E Sbjct: 238 FERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDY 297 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL- 124 Y+V E GGE+FD +V + R+ E + F Q++ AV + H I+HRDLK EN+LL Sbjct: 298 -YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS 356 Query: 125 --DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELF--EGKEYDGPKVDIWSLGVV 180 + + IKI DFG S + L++T CG+P Y APE+ G VD WSLGV+ Sbjct: 357 SQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVI 416 Query: 181 LYVLVCGALPF-DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239 L++ + G PF + T +L+ ++ SGK+ +PE+ + L L Sbjct: 417 LFICLSGYPPFSEHRTQVSLKDQITSGKY--------NFIPEVWAEVSEKALD------L 462 Query: 240 IRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAE 278 ++ +LV+DP R + E+ +H W++ D F L++E Sbjct: 463 VKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSE 501 >gi|17379144|sp|P11801|KPSH1_HUMAN Serine/threonine-protein kinase H1 (PSK-H1) Length = 424 Score = 143 bits (360), Expect = 5e-34 Identities = 85/253 (33%), Positives = 134/253 (52%), Gaps = 22/253 (8%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T+Q AIK+I+ E + E+++++ + H +II+L +V ET+ +Y+V E A+G Sbjct: 120 TRQPYAIKMIETKY--REGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATG 177 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKI 132 GE+FD ++A G E++A R + ++ V + H I HRDLK ENLL + I I Sbjct: 178 GELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIII 237 Query: 133 ADFGFSNLFTPGQ--LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 DFG ++ G L+KT CG+P Y APE+ K Y VD+W+LGV+ Y+L+ G +P Sbjct: 238 TDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN-SVDMWALGVIAYILLSGTMP 296 Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 F+ L ++L GK+ S P + K I +L +DP Sbjct: 297 FEDDNRTRLYRQILRGKYS----YSGEPWPSVSNLAK----------DFIDRLLTVDPGA 342 Query: 251 RLSMEQICKHKWM 263 R++ Q +H W+ Sbjct: 343 RMTALQALRHPWV 355 >gi|2833281|sp|Q16816|PHKG1_HUMAN Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (Phosphorylase kinase gamma subunit 1) Length = 387 Score = 142 bits (359), Expect = 6e-34 Identities = 87/262 (33%), Positives = 136/262 (51%), Gaps = 27/262 (10%) Query: 16 TKQLVAIKIIDKT---QLDEENLKKI----FREVQIMKMLC-HPHIIRLYQVMETERMIY 67 T Q A+K+ID T E ++++ +EV I++ + HP+II+L ET + Sbjct: 42 TSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFF 101 Query: 68 LVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN 127 LV + GE+FD+L ++EKE R+ + ++ + H NIVHRDLK EN+LLD N Sbjct: 102 LVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDN 161 Query: 128 LNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD-----GPKVDIWSLGVVLY 182 +NIK+ DFGFS PG+ L+ CG+P Y APE+ E + G +VD+WS GV++Y Sbjct: 162 MNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMY 221 Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRH 242 L+ G+ PF + ++SG ++ PE D + L+ Sbjct: 222 TLLAGSPPFWHRKQMLMLRMIMSGNYQFG-------SPEWDDYSDT-------VKDLVSR 267 Query: 243 MLVLDPNKRLSMEQICKHKWMK 264 LV+ P R + E+ H + + Sbjct: 268 FLVVQPQNRYTAEEALAHPFFQ 289 >gi|38605718|sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1) Length = 1432 Score = 142 bits (359), Expect = 6e-34 Identities = 88/243 (36%), Positives = 129/243 (53%), Gaps = 23/243 (9%) Query: 38 IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKF 97 I REV I+K + HP++I L++V E + + L+ E +GGE+FD L + E+EA Sbjct: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL 120 Query: 98 KQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL---NIKIADFGFSNLFTPGQLLKTWCGS 153 KQI+ VY+ H I H DLK EN +LLD N+ IKI DFG ++ G K G+ Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180 Query: 154 PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARV--LSGKFRIP 211 P + APE+ E G + D+WS+GV+ Y+L+ GA PF G T Q A V ++ +F Sbjct: 181 PEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDE 239 Query: 212 FFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPN 271 +F +T A + IR +LV DP KR++++ +H W+K D Sbjct: 240 YFSNTS----------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQA 283 Query: 272 FDR 274 R Sbjct: 284 LSR 286 >gi|20177970|sp|Q9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II alpha chain (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II alpha subunit) Length = 478 Score = 141 bits (355), Expect = 2e-33 Identities = 86/250 (34%), Positives = 135/250 (54%), Gaps = 19/250 (7%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 Q A KII+ +L + +K+ RE +I ++L HP+I+RL+ + E YL+ + +GGE Sbjct: 37 QEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGE 96 Query: 78 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIAD 134 +F+ +VA +E +A +QI+ AV CH +VHRDLK ENLLL + L +K+AD Sbjct: 97 LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD 156 Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 FG + + Q + G+P Y +PE+ Y G VD+W+ GV+LY+L+ G PF Sbjct: 157 FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWD 215 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253 L ++ +G + P PE D E + LI ML ++P+KR++ Sbjct: 216 EDQHRLYQQIKAGAYDFP-------SPEWD-------TVTPEAKDLINKMLTINPSKRIT 261 Query: 254 MEQICKHKWM 263 + KH W+ Sbjct: 262 AAEALKHPWI 271 >gi|56404655|sp|Q96NX5|KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III) Length = 476 Score = 140 bits (354), Expect = 2e-33 Identities = 86/253 (33%), Positives = 130/253 (51%), Gaps = 25/253 (9%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T +L A+K I K+ ++ + E+ ++K + H +I+ L + E+ YLV + SG Sbjct: 45 TGKLFALKCIKKSPAFRDS--SLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSG 102 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKI 132 GE+FD ++ G EK+A +Q+++AV + H IVHRDLK ENLL + N I I Sbjct: 103 GELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMI 162 Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 DFG S + G ++ T CG+P Y APE+ K Y VD WS+GV+ Y+L+CG PF Sbjct: 163 TDFGLSKMEQNG-IMSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFY 220 Query: 193 GSTLQNLRARVLSG--KFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 T L ++ G +F PF+ + I H+L DPN+ Sbjct: 221 EETESKLFEKIKEGYYEFESPFWDDIS----------------ESAKDFICHLLEKDPNE 264 Query: 251 RLSMEQICKHKWM 263 R + E+ H W+ Sbjct: 265 RYTCEKALSHPWI 277 >gi|7531055|sp|O14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 Length = 476 Score = 140 bits (352), Expect = 4e-33 Identities = 77/182 (42%), Positives = 111/182 (60%), Gaps = 8/182 (4%) Query: 16 TKQLVAIKIID-KTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 T++ VA+KI+D K +D EN+KK E+ I KML H ++++ Y + YL EY Sbjct: 31 TEEAVAVKIVDMKRAVDCPENIKK---EICINKMLNHENVVKFYGHRREGNIQYLFLEYC 87 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 SGGE+FD + M E +A+R F Q++ V + H I HRD+K ENLLLD N+KI+ Sbjct: 88 SGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKIS 147 Query: 134 DFGFSNLF---TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 DFG + +F +LL CG+ PY APEL + +E+ VD+WS G+VL ++ G LP Sbjct: 148 DFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELP 207 Query: 191 FD 192 +D Sbjct: 208 WD 209 >gi|12643414|sp|Q13557|KCC2D_HUMAN Calcium/calmodulin-dependent protein kinase type II delta chain (CaM-kinase II delta chain) (CaM kinase II delta subunit) (CaMK-II delta subunit) Length = 499 Score = 139 bits (351), Expect = 5e-33 Identities = 87/252 (34%), Positives = 134/252 (53%), Gaps = 19/252 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T Q A KII+ +L + +K+ RE +I ++L HP+I+RL+ + E YLV + +G Sbjct: 36 TGQGYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTG 95 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKI 132 GE+F+ +VA +E +A +QI+ +V CH IVHRDLK ENLLL + +K+ Sbjct: 96 GELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKL 155 Query: 133 ADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 ADFG + + Q + G+P Y +PE+ Y G VD+W+ GV+LY+L+ G PF Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDMWACGVILYILLVGYPPF 214 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 L ++ +G + P PE D E + LI ML ++P KR Sbjct: 215 WDEDQHRLYQQIKAGAYDFP-------SPEWD-------TVTPEAKDLINKMLTINPAKR 260 Query: 252 LSMEQICKHKWM 263 ++ + KH W+ Sbjct: 261 ITASEALKHPWI 272 >gi|51316189|sp|O00444|PLK4_HUMAN Serine/threonine-protein kinase PLK4 (Polo-like kinase 4) (PLK-4) (Serine/threonine protein kinase Sak) (Serine/threonine-protein kinase 18) Length = 970 Score = 139 bits (351), Expect = 5e-33 Identities = 88/257 (34%), Positives = 132/257 (51%), Gaps = 22/257 (8%) Query: 20 VAIKIIDKTQLDEENL-KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78 VAIK+IDK + + + +++ EV+I L HP I+ LY E +YLV E GE+ Sbjct: 38 VAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEM 97 Query: 79 FDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 +L + +E EAR QI+T + + H I+HRDL NLLL N+NIKIADFG Sbjct: 98 NRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGL 157 Query: 138 -SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196 + L P + T CG+P Y +PE+ + G + D+WSLG + Y L+ G PFD T+ Sbjct: 158 ATQLKMPHEKHYTLCGTPNYISPEI-ATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTV 216 Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256 +N +V+ + +P F+S E + LI +L +P RLS+ Sbjct: 217 KNTLNKVVLADYEMPTFLS------------------IEAKDLIHQLLRRNPADRLSLSS 258 Query: 257 ICKHKWMKLGDADPNFD 273 + H +M + + D Sbjct: 259 VLDHPFMSRNSSTKSKD 275 >gi|38604691|sp|O43293|DAPK3_HUMAN Death-associated protein kinase 3 (DAP kinase 3) (DAP-like kinase) (Dlk) (ZIP-kinase) Length = 454 Score = 139 bits (349), Expect = 9e-33 Identities = 85/252 (33%), Positives = 134/252 (53%), Gaps = 23/252 (9%) Query: 21 AIKIIDKTQLDEE----NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 A K I K +L + ++I REV I++ + HP+II L+ + E + + L+ E SGG Sbjct: 40 AAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGG 99 Query: 77 EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL---NIKI 132 E+FD L + E EA + KQI+ V++ H + I H DLK EN +LLD N+ IK+ Sbjct: 100 ELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKL 159 Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 DFG ++ G K G+P + APE+ E G + D+WS+GV+ Y+L+ GA PF Sbjct: 160 IDFGIAHKIEAGNEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFL 218 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 G T Q + + + + D+ + +A + IR +LV DP +R+ Sbjct: 219 GETKQETLTNISAVNY------------DFDEEYFSNTSELA--KDFIRRLLVKDPKRRM 264 Query: 253 SMEQICKHKWMK 264 ++ Q +H W+K Sbjct: 265 TIAQSLEHSWIK 276 >gi|12643413|sp|Q13554|KCC2B_HUMAN Calcium/calmodulin-dependent protein kinase type II beta chain (CaM-kinase II beta chain) (CaM kinase II beta subunit) (CaMK-II beta subunit) Length = 664 Score = 139 bits (349), Expect = 9e-33 Identities = 86/247 (34%), Positives = 133/247 (53%), Gaps = 19/247 (7%) Query: 21 AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD 80 A KII+ +L + +K+ RE +I ++L H +I+RL+ + E YLV + +GGE+F+ Sbjct: 41 AAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFE 100 Query: 81 HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFGF 137 +VA +E +A +QI+ AV CH +VHRDLK ENLLL + +K+ADFG Sbjct: 101 DIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGL 160 Query: 138 S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196 + + Q + G+P Y +PE+ KE G VDIW+ GV+LY+L+ G PF Sbjct: 161 AIEVQGDQQAWFGFAGTPGYLSPEVLR-KEAYGKPVDIWACGVILYILLVGYPPFWDEDQ 219 Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256 L ++ +G + P PE D E ++LI ML ++P KR++ + Sbjct: 220 HKLYQQIKAGAYDFP-------SPEWD-------TVTPEAKNLINQMLTINPAKRITAHE 265 Query: 257 ICKHKWM 263 KH W+ Sbjct: 266 ALKHPWV 272 >gi|20178304|sp|Q13555|KCC2G_HUMAN Calcium/calmodulin-dependent protein kinase type II gamma chain (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II gamma subunit) Length = 472 Score = 138 bits (348), Expect = 1e-32 Identities = 87/250 (34%), Positives = 134/250 (53%), Gaps = 19/250 (7%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 Q A KII+ +L + +K+ RE +I ++L HP+I+RL+ + E YLV + +GGE Sbjct: 38 QEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGE 97 Query: 78 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIAD 134 +F+ +VA +E +A QI+ +V H +IVHRDLK ENLLL + +K+AD Sbjct: 98 LFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLAD 157 Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 FG + + Q + G+P Y +PE+ Y G VDIW+ GV+LY+L+ G PF Sbjct: 158 FGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWD 216 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253 L ++ +G + P PE D E ++LI ML ++P KR++ Sbjct: 217 EDQHKLYQQIKAGAYDFP-------SPEWD-------TVTPEAKNLINQMLTINPAKRIT 262 Query: 254 MEQICKHKWM 263 +Q KH W+ Sbjct: 263 ADQALKHPWV 272 >gi|37999482|sp|O75582|KS6A5_HUMAN Ribosomal protein S6 kinase alpha 5 (Nuclear mitogen-and stress-activated protein kinase-1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 802 Score = 136 bits (343), Expect = 4e-32 Identities = 95/268 (35%), Positives = 141/268 (52%), Gaps = 38/268 (14%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLC--HPHIIRLYQVMETERMIYLVTE 71 +++ Q A+KII K E N +K E+ +K LC HP+I++L++V + +LV E Sbjct: 446 KKSNQAFAVKIISKRM--EANTQK---EITALK-LCEGHPNIVKLHEVFHDQLHTFLVME 499 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128 +GGE+F+ + +E EA +++V+AV H +VHRDLK ENLL + NL Sbjct: 500 LLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNL 559 Query: 129 NIKIADFGFSNLFTP-GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187 IKI DFGF+ L P Q LKT C + YAAPEL YD D+WSLGV+LY ++ G Sbjct: 560 EIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ESCDLWSLGVILYTMLSG 618 Query: 188 ALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSI---------AECEH 238 +PF ++ E+ K++K G S E + Sbjct: 619 QVPFQSHDRS----------------LTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 662 Query: 239 LIRHMLVLDPNKRLSMEQICKHKWMKLG 266 LI+ +L +DPNKRL M + ++W++ G Sbjct: 663 LIQGLLTVDPNKRLKMSGLRYNEWLQDG 690 Score = 114 bits (284), Expect = 3e-25 Identities = 77/248 (31%), Positives = 130/248 (52%), Gaps = 28/248 (11%) Query: 15 ETKQLVAIKIIDKTQLDEE--NLKKIFREVQIMKMLCH-PHIIRLYQVMETERMIYLVTE 71 +T +L A+K++ K + ++ + E Q+++ + P ++ L+ +TE ++L+ + Sbjct: 73 DTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILD 132 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 Y +GGE+F HL R E E + +IV A+ H I++RD+K EN+LLD+N ++ Sbjct: 133 YINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVV 192 Query: 132 IADFGFSNLFTPGQLLK--TWCGSPPYAAPELFEGKEYDGPK-VDIWSLGVVLYVLVCGA 188 + DFG S F + + ++CG+ Y AP++ G + K VD WSLGV++Y L+ GA Sbjct: 193 LTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGA 252 Query: 189 LPFDGSTLQNLRA----RVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244 PF +N +A R+L + P MS A + LI+ +L Sbjct: 253 SPFTVDGEKNSQAEISRRILKSEPPYPQEMS------------------ALAKDLIQRLL 294 Query: 245 VLDPNKRL 252 + DP KRL Sbjct: 295 MKDPKKRL 302 >gi|6136124|sp|O75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (Unc-51-like kinase 1) Length = 1050 Score = 136 bits (343), Expect = 4e-32 Identities = 77/201 (38%), Positives = 113/201 (56%), Gaps = 11/201 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K I+K L + + +E++I+K L H +I+ LY E +YLV EY +GG++ Sbjct: 43 VAVKCINKKNLAKSQTL-LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLA 101 Query: 80 DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD------ANLN---I 130 D+L A ++E R +QI A+ H + I+HRDLK +N+LL AN N + Sbjct: 102 DYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRV 161 Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 KIADFGF+ + T CGSP Y APE+ + YDG K D+WS+G ++Y + G P Sbjct: 162 KIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKAP 220 Query: 191 FDGSTLQNLRARVLSGKFRIP 211 F S+ Q+LR K +P Sbjct: 221 FQASSPQDLRLFYEKNKTLVP 241 >gi|6225242|sp|O15075|DCAK1_HUMAN Serine/threonine-protein kinase DCAMKL1 (Doublecortin-like and CAM kinase-like 1) Length = 740 Score = 135 bits (340), Expect = 1e-31 Identities = 98/328 (29%), Positives = 163/328 (49%), Gaps = 29/328 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 + T + A+KII K++ + I EV I++ + HP+I+ L + M+ +YLV E Sbjct: 410 RSTAREYALKIIKKSKCRGKE-HMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELV 468 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLN 129 GG++FD + + + E++A + +A+ + H NIVHRD+K ENLL+ D + + Sbjct: 469 KGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKS 528 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 +K+ DFG + + L T CG+P Y APE+ Y G KVDIW+ GV+ Y+L+CG Sbjct: 529 LKLGDFGLATIVDGP--LYTVCGTPTYVAPEIIAETGY-GLKVDIWAAGVITYILLCGFP 585 Query: 190 PFDGS--TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247 PF GS + L ++L G+ P P D + + LI ML++D Sbjct: 586 PFRGSGDDQEVLFDQILMGQVDFP-------SPYWDNVSDS-------AKELITMMLLVD 631 Query: 248 PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV---LLAMEDMGL 304 ++R S Q+ +H W+ D P + ++ ++K+ P + + L Sbjct: 632 VDQRFSAVQVLEHPWVN-DDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTAL 690 Query: 305 DKE-QTLQPDGTLNLDSDEGEEPSPEAL 331 DKE Q + ++ S +P+P L Sbjct: 691 DKERQVFRRRRNQDVRSRYKAQPAPPEL 718 >gi|1170703|sp|P31751|AKT2_HUMAN RAC-beta serine/threonine-protein kinase (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta) Length = 481 Score = 133 bits (335), Expect = 4e-31 Identities = 90/303 (29%), Positives = 148/303 (48%), Gaps = 37/303 (12%) Query: 16 TKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T + A+KI+ K + ++ + E ++++ HP + L +T + V EYA+ Sbjct: 174 TGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYAN 233 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GGE+F HL E+ AR +IV+A+ + H R++V+RD+K ENL+LD + +IKI D Sbjct: 234 GGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITD 293 Query: 135 FGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 FG + G +KT+CG+P Y APE+ E +Y G VD W LGVV+Y ++CG LPF Sbjct: 294 FGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYN 352 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252 + L +L + R P +S E + L+ +L DP +RL Sbjct: 353 QDHERLFELILMEEIRFPRTLS------------------PEAKSLLAGLLKKDPKQRLG 394 Query: 253 ----SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 308 +++ +H++ L Q + +++ + P V ++ D E Sbjct: 395 GGPSDAKEVMEHRFF-----------LSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443 Query: 309 TLQ 311 T Q Sbjct: 444 TAQ 446 >gi|125210|sp|P22694|KAPCB_HUMAN cAMP-dependent protein kinase, beta-catalytic subunit (PKA C-beta) Length = 351 Score = 132 bits (331), Expect = 1e-30 Identities = 84/260 (32%), Positives = 132/260 (50%), Gaps = 31/260 (11%) Query: 16 TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T+Q A+KI+DK ++ + + ++ E +I++ + P ++RL + +Y+V EY Sbjct: 66 TEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVP 125 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GGE+F HL GR +E AR QIV + H ++++RDLK ENLL+D I++ D Sbjct: 126 GGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTD 185 Query: 135 FGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 FGF+ +TW CG+P Y APE+ K Y+ VD W+LGV++Y + G PF Sbjct: 186 FGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFF 240 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 + +++SGK R P S+ L + L+R++L +D KR Sbjct: 241 ADQPIQIYEKIVSGKVRFPSHFSSDL------------------KDLLRNLLQVDLTKRF 282 Query: 253 -----SMEQICKHKWMKLGD 267 + I HKW D Sbjct: 283 GNLKNGVSDIKTHKWFATTD 302 >gi|38605084|sp|Q9UIK4|DAPK2_HUMAN Death-associated protein kinase 2 (DAP kinase 2) (DAP-kinase related protein 1) (DRP-1) Length = 370 Score = 131 bits (330), Expect = 1e-30 Identities = 84/234 (35%), Positives = 126/234 (53%), Gaps = 23/234 (9%) Query: 36 KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARR 95 ++I REV I++ + H ++I L+ V E + L+ E SGGE+FD L ++E+EA Sbjct: 69 EEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATS 128 Query: 96 KFKQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL---NIKIADFGFSNLFTPGQLLKTWC 151 KQI+ V + H + I H DLK EN +LLD N+ +IK+ DFG ++ G K Sbjct: 129 FIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIF 188 Query: 152 GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARV--LSGKFR 209 G+P + APE+ E G + D+WS+GV+ Y+L+ GA PF G T Q A + +S F Sbjct: 189 GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFD 247 Query: 210 IPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263 FF T EL K IR +LV + KRL++++ +H W+ Sbjct: 248 EEFFSQTS---ELAK-------------DFIRKLLVKETRKRLTIQEALRHPWI 285 >gi|11133131|sp|Q9UK32|KS6A6_HUMAN Ribosomal protein S6 kinase alpha 6 (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 131 bits (329), Expect = 2e-30 Identities = 92/264 (34%), Positives = 135/264 (51%), Gaps = 28/264 (10%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T A+KIIDK++ D +I +M+ HP+II L V + R +YLVT+ G Sbjct: 448 TNMEFAVKIIDKSKRDPSEEIEI-----LMRYGQHPNIITLKDVFDDGRYVYLVTDLMKG 502 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANL---NIK 131 GE+ D ++ +E+EA I V + HC+ +VHRDLK N+L +D + +I+ Sbjct: 503 GELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIR 562 Query: 132 IADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 I DFGF+ L LL T C + + APE+ + YD DIWSLGV+ Y ++ G P Sbjct: 563 ICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDA-ACDIWSLGVLFYTMLAGYTP 621 Query: 191 F---DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247 F T + + R+ +GKF +S G + K L+ HML +D Sbjct: 622 FANGPNDTPEEILLRIGNGKFS----LSGGNWDNISDGAK----------DLLSHMLHMD 667 Query: 248 PNKRLSMEQICKHKWMKLGDADPN 271 P++R + EQI KH W+ D PN Sbjct: 668 PHQRYTAEQILKHSWITHRDQLPN 691 Score = 113 bits (283), Expect = 4e-25 Identities = 70/230 (30%), Positives = 115/230 (50%), Gaps = 5/230 (2%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 QL A+K++ K L + + E I+ + HP I++L+ +TE +YL+ ++ GG+ Sbjct: 100 QLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD 159 Query: 78 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 +F L E++ + ++ A+ H IV+RDLK EN+LLD +IK+ DFG Sbjct: 160 VFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGL 219 Query: 138 S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196 S + ++CG+ Y APE+ + + D WS GV+++ ++ G LPF G Sbjct: 220 SKESVDQEKKAYSFCGTVEYMAPEVVNRRGH-SQSADWWSYGVLMFEMLTGTLPFQGKDR 278 Query: 197 QNLRARVLSGKFRIPFFMST---GLVPELDKRLKAGCLSIAECEHLIRHM 243 +L K +P F+S L+ L KR A L E + RH+ Sbjct: 279 NETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHL 328 >gi|59797954|sp|Q8N568|DCAK2_HUMAN Serine/threonine-protein kinase DCAMKL2 (Doublecortin-like and CAM kinase-like 2) Length = 766 Score = 131 bits (329), Expect = 2e-30 Identities = 86/257 (33%), Positives = 136/257 (52%), Gaps = 26/257 (10%) Query: 14 QETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 + T + A+KIIDK + +E+L I EV I++ + HP+II L + MET ++LV E Sbjct: 414 RSTGKEFALKIIDKAKCCGKEHL--IENEVSILRRVKHPNIIMLVEEMETATELFLVMEL 471 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANL 128 GG++FD + + + E++ + A+ + H +IVHRD+K ENLL+ D Sbjct: 472 VKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTK 531 Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188 ++K+ DFG + + L T CG+P Y APE+ Y G KVDIW+ GV+ Y+L+CG Sbjct: 532 SLKLGDFGLATVVEGP--LYTVCGTPTYVAPEIIAETGY-GLKVDIWAAGVITYILLCGF 588 Query: 189 LPF--DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246 PF + + ++L ++L+GK P P D + + LI ML + Sbjct: 589 PPFRSENNLQEDLFDQILAGKLEFP-------APYWDNITDS-------AKELISQMLQV 634 Query: 247 DPNKRLSMEQICKHKWM 263 + R + QI H W+ Sbjct: 635 NVEARCTAGQILSHPWV 651 >gi|12643943|sp|Q9Y243|AKT3_HUMAN RAC-gamma serine/threonine-protein kinase (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2) Length = 479 Score = 130 bits (328), Expect = 2e-30 Identities = 90/298 (30%), Positives = 142/298 (47%), Gaps = 37/298 (12%) Query: 21 AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 A+KI+ K + ++ + E +++K HP + L +T+ + V EY +GGE+F Sbjct: 175 AMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 234 Query: 80 DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S 138 HL +E R +IV+A+ + H IV+RDLK ENL+LD + +IKI DFG Sbjct: 235 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294 Query: 139 NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 198 T +KT+CG+P Y APE+ E +Y G VD W LGVV+Y ++CG LPF + Sbjct: 295 EGITDAATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 353 Query: 199 LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL-----S 253 L +L + P +S ++ + L+ +L+ DPNKRL Sbjct: 354 LFELILMEDIKFPRTLS------------------SDAKSLLSGLLIKDPNKRLGGGPDD 395 Query: 254 MEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQ 311 ++I +H + Q + +++ V P V + D+E T Q Sbjct: 396 AKEIMRHSFFS-----------GVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQ 442 >gi|14423930|sp|Q9UEE5|ST17A_HUMAN Serine/threonine-protein kinase 17A (DAP kinase-related apoptosis-inducing protein kinase 1) Length = 414 Score = 130 bits (328), Expect = 2e-30 Identities = 91/285 (31%), Positives = 143/285 (50%), Gaps = 28/285 (9%) Query: 21 AIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEIF 79 A K + K + ++ +I E+ ++++ +P +I L++V ET + LV EYA+GGEIF Sbjct: 88 AAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIF 147 Query: 80 DHLVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKIAD 134 D VA A EK+ +R +QI+ V+F H R++VH DLK +N+LL + +IKI D Sbjct: 148 DQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVD 207 Query: 135 FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFD 192 FG S + + L+ G+P Y APE+ YD D+WS+GV+ YV++ G PF Sbjct: 208 FGLSRILKNSEELREIMGTPEYVAPEIL---SYDPISMATDMWSIGVLTYVMLTGISPFL 264 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 G+ Q + M+ E L + IR +LV P R Sbjct: 265 GNDKQETFLNISQ--------MNLSYSEEEFDVLSESAVD------FIRTLLVKKPEDRA 310 Query: 253 SMEQICKHKWMKLGD-ADPNF--DRLIAECQQLKEERQVDPLNED 294 + E+ KH W+ +P+F ++ + E L+E V +N D Sbjct: 311 TAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSD 355 >gi|1709648|sp|P51817|PRKX_HUMAN Serine/threonine-protein kinase PRKX (Protein kinase PKX1) Length = 358 Score = 130 bits (326), Expect = 4e-30 Identities = 81/261 (31%), Positives = 134/261 (51%), Gaps = 35/261 (13%) Query: 17 KQLVAIKII---DKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 K A+K++ D +L +E + + E ++K + HP +IRL+ ER +Y++ EY Sbjct: 72 KHFFALKVMSIPDVIRLKQE--QHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYV 129 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GGE+F +L GR + +I+ A+ + H + IV+RDLK EN+LLD + +IK+ Sbjct: 130 PGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLT 189 Query: 134 DFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 DFGF+ +TW CG+P Y APE+ + K + G VD W+LG++++ ++ G PF Sbjct: 190 DFGFAKKLVD----RTWTLCGTPEYLAPEVIQSKGH-GRAVDWWALGILIFEMLSGFPPF 244 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 + ++L+GK P LD +K LI+ +LV+D +R Sbjct: 245 FDDNPFGIYQKILAGKIDFP--------RHLDFHVK----------DLIKKLLVVDRTRR 286 Query: 252 L-----SMEQICKHKWMKLGD 267 L + H+W + D Sbjct: 287 LGNMKNGANDVKHHRWFRSVD 307 >gi|1346538|sp|P49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) Length = 400 Score = 129 bits (325), Expect = 5e-30 Identities = 94/320 (29%), Positives = 160/320 (50%), Gaps = 39/320 (12%) Query: 4 VKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH-PHIIRLYQVMET 62 + G ++Q F + T++ A+K++ ++ K REV++ PHI+R+ V E Sbjct: 74 INGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIVDVYEN 126 Query: 63 ----ERMIYLVTEYASGGEIFDHLVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRD 116 + + +V E GGE+F + G A E+EA K I A+ + H NI HRD Sbjct: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 186 Query: 117 LKAENLLLDA---NLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173 +K ENLL + N +K+ DFGF+ T L T C +P Y APE+ ++YD D Sbjct: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD-KSCD 245 Query: 174 IWSLGVVLYVLVCGALPFDG----STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAG 229 +WSLGV++Y+L+CG PF + ++ R+ G++ P PE + + Sbjct: 246 MWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP-------NPEWSEVSE-- 296 Query: 230 CLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQ-V 288 E + LIR++L +P +R+++ + H W+ P + + LKE+++ Sbjct: 297 -----EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP--LHTSRVLKEDKERW 349 Query: 289 DPLNEDVLLAMEDMGLDKEQ 308 + + E++ A+ M +D EQ Sbjct: 350 EDVKEEMTSALATMRVDYEQ 369 >gi|33860173|sp|P22612|KAPCG_HUMAN cAMP-dependent protein kinase, gamma-catalytic subunit (PKA C-gamma) Length = 351 Score = 129 bits (325), Expect = 5e-30 Identities = 83/257 (32%), Positives = 133/257 (51%), Gaps = 31/257 (12%) Query: 14 QETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 QET A+KI++K ++ + + ++ I E +I++ + P +++L + +YLV EY Sbjct: 64 QETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEY 123 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GGE+F L GR +E A Q+V AV + H +++HRDLK ENLL+D +++ Sbjct: 124 VPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQV 183 Query: 133 ADFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 DFGF+ +TW CG+P Y APE+ K Y+ VD W+LGV++Y + G P Sbjct: 184 TDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAVGFPP 238 Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 F + +++SG+ R P +S+ L +HL+R +L +D K Sbjct: 239 FYADQPIQIYEKIVSGRVRFPSKLSSDL------------------KHLLRSLLQVDLTK 280 Query: 251 RL-----SMEQICKHKW 262 R + I HKW Sbjct: 281 RFGNLRNGVGDIKNHKW 297 >gi|125205|sp|P17612|KAPCA_HUMAN cAMP-dependent protein kinase, alpha-catalytic subunit (PKA C-alpha) Length = 351 Score = 128 bits (322), Expect = 1e-29 Identities = 83/262 (31%), Positives = 132/262 (50%), Gaps = 31/262 (11%) Query: 14 QETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 +ET A+KI+DK ++ + + ++ E +I++ + P +++L + +Y+V EY Sbjct: 64 KETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEY 123 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GGE+F HL GR +E AR QIV + H ++++RDLK ENLL+D I++ Sbjct: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183 Query: 133 ADFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 DFGF+ +TW CG+P Y APE+ K Y+ VD W+LGV++Y + G P Sbjct: 184 TDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPP 238 Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 F + +++SGK R P S+ L + L+R++L +D K Sbjct: 239 FFADQPIQIYEKIVSGKVRFPSHFSSDL------------------KDLLRNLLQVDLTK 280 Query: 251 RL-----SMEQICKHKWMKLGD 267 R + I HKW D Sbjct: 281 RFGNLKNGVNDIKNHKWFATTD 302 >gi|20141585|sp|Q05513|KPCZ_HUMAN Protein kinase C, zeta type (nPKC-zeta) Length = 592 Score = 127 bits (320), Expect = 2e-29 Identities = 91/326 (27%), Positives = 157/326 (48%), Gaps = 49/326 (15%) Query: 13 LQETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVT 70 L++ Q+ A+K++ K + D+E++ + E + + +P ++ L+ +T ++LV Sbjct: 271 LKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330 Query: 71 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130 EY +GG++ H+ ++ E+ AR +I A+ F H R I++RDLK +N+LLDA+ +I Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390 Query: 131 KIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 K+ D+G PG T+CG+P Y APE+ G+EY G VD W+LGV+++ ++ G Sbjct: 391 KLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMAGRS 449 Query: 190 PF-------DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRH 242 PF D +T L +L RIP F+S + H+++ Sbjct: 450 PFDIITDNPDMNTEDYLFQVILEKPIRIPRFLS------------------VKASHVLKG 491 Query: 243 MLVLDPNKRL------SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVL 296 L DP +RL I H + + D D L++++ + P + Sbjct: 492 FLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWD-----------LLEKKQALPPFQPQI- 539 Query: 297 LAMEDMGLDKEQTLQPDGTLNLDSDE 322 +D GLD T + L D+ Sbjct: 540 --TDDYGLDNFDTQFTSEPVQLTPDD 563 >gi|37999483|sp|O75676|KS6A4_HUMAN Ribosomal protein S6 kinase alpha 4 (Nuclear mitogen-and stress-activated protein kinase-2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB) Length = 772 Score = 126 bits (317), Expect = 5e-29 Identities = 88/269 (32%), Positives = 141/269 (52%), Gaps = 34/269 (12%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKML-CHPHIIRLYQVMETERMIYLVTEY 72 +++ Q A+KI+ + E N + REV +++ HP+++ L++V + YLV E Sbjct: 431 RQSGQEFAVKILSRRL--EANTQ---REVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL 485 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR-NIVHRDLKAENLLL---DANL 128 GGE+ +H+ +E EA + + +V+AV F H +VHRDLK EN+L Sbjct: 486 LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGA 545 Query: 129 NIKIADFGFSNL--FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC 186 +KI DFGF+ L +PG ++T C + YAAPEL + YD D+WSLGV+LY+++ Sbjct: 546 PVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD-ESCDLWSLGVILYMMLS 604 Query: 187 GALPFDGSTLQ-------NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239 G +PF G++ Q + ++ G+F LD G E + L Sbjct: 605 GQVPFQGASGQGGQSQAAEIMCKIREGRF------------SLDGEAWQGVSE--EAKEL 650 Query: 240 IRHMLVLDPNKRLSMEQICKHKWMKLGDA 268 +R +L +DP KRL +E + W++ G A Sbjct: 651 VRGLLTVDPAKRLKLEGLRGSSWLQDGSA 679 Score = 110 bits (275), Expect = 3e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 23/242 (9%) Query: 18 QLVAIKIIDKTQLDE--ENLKKIFREVQIMKMLCH-PHIIRLYQVMETERMIYLVTEYAS 74 +L A+K++ K L + + + E +++++ P ++ L+ +T+ ++L+ +Y S Sbjct: 60 KLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVS 119 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GGE+F HL E E R +IV A+ H I++RDLK EN+LLD+ +I + D Sbjct: 120 GGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTD 179 Query: 135 FGFSNLFTPGQLLKT--WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 FG S F + +T +CG+ Y APE+ K G VD WSLG++L+ L+ GA PF Sbjct: 180 FGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFT 239 Query: 193 GSTLQNLRARVLSG--KFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 +N +A V K PF G V + L++ +L DP K Sbjct: 240 LEGERNTQAEVSRRILKCSPPFPPRIGPV----------------AQDLLQRLLCKDPKK 283 Query: 251 RL 252 RL Sbjct: 284 RL 285 >gi|60391226|sp|P31749|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT) Length = 480 Score = 126 bits (316), Expect = 6e-29 Identities = 95/318 (29%), Positives = 151/318 (47%), Gaps = 38/318 (11%) Query: 16 TKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T + A+KI+ K + ++ + E ++++ HP + L +T + V EYA+ Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYAN 231 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC-RNIVHRDLKAENLLLDANLNIKIA 133 GGE+F HL +E AR +IV+A+ + H +N+V+RDLK ENL+LD + +IKI Sbjct: 232 GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKIT 291 Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 DFG G +KT+CG+P Y APE+ E +Y G VD W LGVV+Y ++CG LPF Sbjct: 292 DFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFY 350 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 + L +L + R P + E + L+ +L DP +RL Sbjct: 351 NQDHEKLFELILMEEIRFPRTLG------------------PEAKSLLSGLLKKDPKQRL 392 Query: 253 -----SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKE 307 ++I +H++ F ++ Q + E++ P V + D+E Sbjct: 393 GGGSEDAKEIMQHRF---------FAGIV--WQHVYEKKLSPPFKPQVTSETDTRYFDEE 441 Query: 308 QTLQPDGTLNLDSDEGEE 325 T Q D D+ E Sbjct: 442 FTAQMITITPPDQDDSME 459 >gi|27735175|sp|O14936|CSKP_HUMAN Peripheral plasma membrane protein CASK (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog) Length = 926 Score = 126 bits (316), Expect = 6e-29 Identities = 92/300 (30%), Positives = 150/300 (50%), Gaps = 33/300 (11%) Query: 14 QETKQLVAIKIIDKTQ------LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY 67 +ET Q A+KI+D + L E+LK RE I ML HPHI+ L + ++ M+Y Sbjct: 32 RETGQQFAVKIVDVAKFTSSPGLSTEDLK---REASICHMLKHPHIVELLETYSSDGMLY 88 Query: 68 LVTEYASGGEIFDHLVAHGR----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123 +V E+ G ++ +V +E A +QI+ A+ +CH NI+HRD+K +L Sbjct: 89 MVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVL 148 Query: 124 LDANLN---IKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV 179 L + N +K+ FG + L G + G+P + APE+ + + Y G VD+W GV Sbjct: 149 LASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPY-GKPVDVWGCGV 207 Query: 180 VLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239 +L++L+ G LPF G T + L ++ GK++ M+ + + K L Sbjct: 208 ILFILLSGCLPFYG-TKERLFEGIIKGKYK----MNPRQWSHISESAK----------DL 252 Query: 240 IRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAM 299 +R ML+LDP +R+++ + H W+K D L +QL++ L VL A+ Sbjct: 253 VRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAV 312 >gi|6226833|sp|Q13237|KGP2_HUMAN cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase) Length = 762 Score = 124 bits (311), Expect = 2e-28 Identities = 78/249 (31%), Positives = 124/249 (49%), Gaps = 23/249 (9%) Query: 21 AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 A+K I K + D + + ++ E +I++ LC P I++LY+ + + +Y++ E GGE++ Sbjct: 480 AMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELW 539 Query: 80 DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN 139 L G E ++ + A + H I++RDLK ENL+LDA +K+ DFGF+ Sbjct: 540 SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK 599 Query: 140 LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL 199 GQ T+CG+P Y APE+ K +D VD WSLG+++Y L+ G PF G Sbjct: 600 KIGSGQKTWTFCGTPEYVAPEVILNKGHDF-SVDFWSLGILVYELLTGNPPFSGVDQMMT 658 Query: 200 RARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL-----SM 254 +L G ++ F P E LIR + +P +RL + Sbjct: 659 YNLILKGIEKMDFPRKITRRP----------------EDLIRRLCRQNPTERLGNLKNGI 702 Query: 255 EQICKHKWM 263 I KH+W+ Sbjct: 703 NDIKKHRWL 711 >gi|1730070|sp|P51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) Length = 740 Score = 124 bits (311), Expect = 2e-28 Identities = 90/266 (33%), Positives = 136/266 (51%), Gaps = 30/266 (11%) Query: 16 TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T A+KIIDK++ D E ++ + R Q HP+II L V + + +Y+VTE Sbjct: 444 TNMEFAVKIIDKSKRDPTEEIEILLRYGQ------HPNIITLKDVYDDGKYVYVVTELMK 497 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANLN---I 130 GGE+ D ++ +E+EA I V + H + +VHRDLK N+L +D + N I Sbjct: 498 GGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESI 557 Query: 131 KIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 +I DFGF+ L LL T C + + APE+ + + YD DIWSLGV+LY ++ G Sbjct: 558 RICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGVLLYTMLTGYT 616 Query: 190 PF---DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246 PF T + + AR+ SGKF +S G + K L+ ML + Sbjct: 617 PFANGPDDTPEEILARIGSGKFS----LSGGYWNSVSDTAK----------DLVSKMLHV 662 Query: 247 DPNKRLSMEQICKHKWMKLGDADPNF 272 DP++RL+ + +H W+ D P + Sbjct: 663 DPHQRLTAALVLRHPWIVHWDQLPQY 688 Score = 114 bits (285), Expect = 2e-25 Identities = 72/268 (26%), Positives = 128/268 (47%), Gaps = 25/268 (9%) Query: 15 ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 + +QL A+K++ K L + + E I+ + HP I++L+ +TE +YL+ ++ Sbjct: 92 DARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLR 151 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GG++F L E++ + ++ A+ H I++RDLK EN+LLD +IK+ D Sbjct: 152 GGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTD 211 Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 FG S + ++CG+ Y APE+ + + D WS GV+++ ++ G LPF G Sbjct: 212 FGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGTLPFQG 270 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252 + +L K +P F+S E + L+R + +P RL Sbjct: 271 KDRKETMTMILKAKLGMPQFLS------------------PEAQSLLRMLFKRNPANRLG 312 Query: 253 ----SMEQICKHKWMKLGDADPNFDRLI 276 +E+I +H + D + + R I Sbjct: 313 AGPDGVEEIKRHSFFSTIDWNKLYRREI 340 >gi|51338822|sp|Q9H4B4|PLK3_HUMAN Serine/threonine-protein kinase PLK3 (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Proliferation-related kinase) Length = 646 Score = 123 bits (309), Expect = 4e-28 Identities = 76/254 (29%), Positives = 126/254 (49%), Gaps = 21/254 (8%) Query: 15 ETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 ET A+K+I ++++ + + + KI E+++ + L H HI+R E IY+ E Sbjct: 83 ETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELC 142 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 S + A + E E R +QI++ + + H R I+HRDLK N + N+ +K+ Sbjct: 143 SRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVG 202 Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 DFG + L P Q KT CG+P Y APE+ ++ GP+ D+WSLG V+Y L+CG+ PF+ Sbjct: 203 DFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLCGSPPFE 261 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 + L+ + + +P +S L+ +L P R Sbjct: 262 TADLKETYRCIKQVHYTLPASLS------------------LPARQLLAAILRASPRDRP 303 Query: 253 SMEQICKHKWMKLG 266 S++QI +H + G Sbjct: 304 SIDQILRHDFFTKG 317 >gi|1170688|sp|P41743|KPCI_HUMAN Protein kinase C, iota type (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota) Length = 587 Score = 123 bits (308), Expect = 5e-28 Identities = 62/183 (33%), Positives = 111/183 (60%), Gaps = 4/183 (2%) Query: 13 LQETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVT 70 L++T ++ A+K++ K + D+E++ + E + + HP ++ L+ +TE ++ V Sbjct: 264 LKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVI 323 Query: 71 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130 EY +GG++ H+ ++ E+ AR +I A+ + H R I++RDLK +N+LLD+ +I Sbjct: 324 EYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHI 383 Query: 131 KIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 K+ D+G PG T+CG+P Y APE+ G++Y G VD W+LGV+++ ++ G Sbjct: 384 KLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY-GFSVDWWALGVLMFEMMAGRS 442 Query: 190 PFD 192 PFD Sbjct: 443 PFD 445 >gi|41017453|sp|O43930|PRKY_HUMAN Serine/threonine-protein kinase PRKY Length = 277 Score = 122 bits (307), Expect = 7e-28 Identities = 67/208 (32%), Positives = 113/208 (54%), Gaps = 12/208 (5%) Query: 17 KQLVAIKIIDKTQLDEENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 K A+K++ + ++ + E ++K + HP +IRL+ ER +Y++ EY G Sbjct: 72 KHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPG 131 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GE+F +L G + +I+ A+ + H + IV+RDLK EN+LLD + +IK+ DF Sbjct: 132 GELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDF 191 Query: 136 GFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 GF+ +TW CG+P Y APE+ + K + G VD W+LG++++ ++ G PF Sbjct: 192 GFAKKLVD----RTWTLCGTPEYLAPEVIQSKGH-GRAVDWWALGILIFEMLSGFPPFFD 246 Query: 194 STLQNLRARVLSGKFRIP----FFMSTG 217 + ++L+GK P F + TG Sbjct: 247 DNPFGIYQKILAGKLYFPRHLDFHVKTG 274 >gi|20178306|sp|Q15418|KS6A1_HUMAN Ribosomal protein S6 kinase alpha 1 (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) Length = 735 Score = 122 bits (307), Expect = 7e-28 Identities = 88/264 (33%), Positives = 137/264 (51%), Gaps = 30/264 (11%) Query: 16 TKQLVAIKIIDKTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T A+K+IDK++ D E ++ + R Q HP+II L V + + +YLVTE Sbjct: 440 TNMEYAVKVIDKSKRDPSEEIEILLRYGQ------HPNIITLKDVYDDGKHVYLVTELMR 493 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANLN---I 130 GGE+ D ++ +E+EA I V + H + +VHRDLK N+L +D + N + Sbjct: 494 GGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECL 553 Query: 131 KIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 +I DFGF+ L LL T C + + APE+ + + YD DIWSLG++LY ++ G Sbjct: 554 RICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD-EGCDIWSLGILLYTMLAGYT 612 Query: 190 PF---DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246 PF T + + R+ SGKF +S G + + K L+ ML + Sbjct: 613 PFANGPSDTPEEILTRIGSGKFT----LSGGNWNTVSETAK----------DLVSKMLHV 658 Query: 247 DPNKRLSMEQICKHKWMKLGDADP 270 DP++RL+ +Q+ +H W+ D P Sbjct: 659 DPHQRLTAKQVLQHPWVTQKDKLP 682 Score = 111 bits (277), Expect = 2e-24 Identities = 70/244 (28%), Positives = 122/244 (50%), Gaps = 9/244 (3%) Query: 15 ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 ++ L A+K++ K L + + E I+ + HP +++L+ +TE +YL+ ++ Sbjct: 86 DSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLR 145 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GG++F L E++ + ++ + H I++RDLK EN+LLD +IK+ D Sbjct: 146 GGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTD 205 Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 FG S + ++CG+ Y APE+ ++ D WS GV+++ ++ G+LPF G Sbjct: 206 FGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQG 264 Query: 194 STLQNLRARVLSGKFRIPFFMST---GLVPELDKRLKAGCLSIAE--CEHLIRHML--VL 246 + +L K +P F+ST L+ L KR A L E + RH+ + Sbjct: 265 KDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 324 Query: 247 DPNK 250 D NK Sbjct: 325 DWNK 328 >gi|22096374|sp|Q9NYY3|PLK2_HUMAN Serine/threonine-protein kinase PLK2 (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum inducible kinase) Length = 685 Score = 122 bits (306), Expect = 9e-28 Identities = 75/264 (28%), Positives = 135/264 (51%), Gaps = 24/264 (9%) Query: 18 QLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 ++ A KII +++ + + + KI +E+++ ++L H H+++ Y E + IY++ EY S Sbjct: 106 KVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRR 165 Query: 77 EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136 + L A + E E R +QIV+ + + H + I+HRDLK N ++ + +K+ DFG Sbjct: 166 SMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFG 225 Query: 137 FSNLFTP-GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195 + P +T CG+P Y +PE+ K+ G + DIW+LG V+Y ++ G PF+ + Sbjct: 226 LAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIWALGCVMYTMLLGRPPFETTN 284 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255 L+ + ++ +P + +A +HLI ML +P R S++ Sbjct: 285 LKETYRCIREARYTMPSSL------------------LAPAKHLIASMLSKNPEDRPSLD 326 Query: 256 QICKHKWMKLGDADPNFDRLIAEC 279 I +H + G DRL + C Sbjct: 327 DIIRHDFFLQGFTP---DRLSSSC 347 >gi|6166243|sp|Q15349|KS6A2_HUMAN Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) Length = 733 Score = 121 bits (303), Expect = 2e-27 Identities = 82/252 (32%), Positives = 130/252 (51%), Gaps = 30/252 (11%) Query: 21 AIKIIDKTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 A+KIIDK++ D E ++ + R Q HP+II L V + + +YLV E GGE+ Sbjct: 442 AVKIIDKSKRDPSEEIEILLRYGQ------HPNIITLKDVYDDGKFVYLVMELMRGGELL 495 Query: 80 DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADF 135 D ++ +E+EA I + + H + +VHRDLK N+L + +I++ DF Sbjct: 496 DRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDF 555 Query: 136 GFSNLFTPGQ-LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF--- 191 GF+ G LL T C + + APE+ + + YD DIWSLG++LY ++ G PF Sbjct: 556 GFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGILLYTMLAGFTPFANG 614 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 T + + AR+ SGK+ +S G + K ++ ML +DP++R Sbjct: 615 PDDTPEEILARIGSGKYA----LSGGNWDSISDAAK----------DVVSKMLHVDPHQR 660 Query: 252 LSMEQICKHKWM 263 L+ Q+ KH W+ Sbjct: 661 LTAMQVLKHPWV 672 Score = 114 bits (285), Expect = 2e-25 Identities = 71/249 (28%), Positives = 122/249 (48%), Gaps = 25/249 (10%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 QL A+K++ K L + + E I+ + HP I++L+ +TE +YL+ ++ GG+ Sbjct: 86 QLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD 145 Query: 78 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 +F L E++ + ++ A+ H I++RDLK EN+LLD +IKI DFG Sbjct: 146 LFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL 205 Query: 138 S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196 S + ++CG+ Y APE+ + + D WS GV+++ ++ G+LPF G Sbjct: 206 SKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGSLPFQGKDR 264 Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL---- 252 + A +L K +P F+S E + L+R + +P RL Sbjct: 265 KETMALILKAKLGMPQFLS------------------GEAQSLLRALFKRNPCNRLGAGI 306 Query: 253 -SMEQICKH 260 +E+I +H Sbjct: 307 DGVEEIKRH 315 >gi|1346393|sp|P24723|KPCL_HUMAN Protein kinase C, eta type (nPKC-eta) (PKC-L) Length = 682 Score = 120 bits (302), Expect = 3e-27 Identities = 73/246 (29%), Positives = 135/246 (54%), Gaps = 10/246 (4%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63 G ++ ++ET L A+K++ K L +++++ E +I+ + HP + +L+ +T Sbjct: 366 GKVMLARVKETGDLYAVKVLKKDVILLDDDVECTMTEKRILSLARNHPFLTQLFCCFQTP 425 Query: 64 RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123 ++ V E+ +GG++ H+ R E AR +I++A+ F H + I++RDLK +N+L Sbjct: 426 DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVL 485 Query: 124 LDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182 LD + K+ADFG G T+CG+P Y APE+ + Y GP VD W++GV+LY Sbjct: 486 LDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY-GPAVDWWAMGVLLY 544 Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFM---STGLVPEL---DKRLKAGCLSIAEC 236 ++CG PF+ +L +L+ + P ++ +TG++ + ++ G L+ Sbjct: 545 EMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGE 604 Query: 237 EHLIRH 242 ++RH Sbjct: 605 HAILRH 610 >gi|41017502|sp|Q96RG2|PASK_HUMAN PAS domain containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) Length = 1323 Score = 120 bits (301), Expect = 3e-27 Identities = 60/170 (35%), Positives = 102/170 (60%), Gaps = 1/170 (0%) Query: 23 KIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE-YASGGEIFDH 81 K+++ +++ L K+ E+ I+ + H +II++ + E + LV E + SG ++F Sbjct: 1034 KVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAF 1093 Query: 82 LVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF 141 + H R+ E A F+Q+V+AV + ++I+HRD+K EN+++ + IK+ DFG + Sbjct: 1094 IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYL 1153 Query: 142 TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 G+L T+CG+ Y APE+ G Y GP++++WSLGV LY LV PF Sbjct: 1154 ERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF 1203 >gi|34098463|sp|Q86SG6|NEK8_HUMAN Serine/threonine-protein kinase Nek8 (NimA-related protein kinase 8) (NIMA-related kinase 12a) Length = 692 Score = 119 bits (297), Expect = 1e-26 Identities = 69/195 (35%), Positives = 110/195 (56%), Gaps = 4/195 (2%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 ++LV IK I Q+ +E + E Q++K+L HP++I Y+ ++ + + EYA GG Sbjct: 27 QKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGG 86 Query: 77 EIFDHLV--AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN-LNIKIA 133 + + + + + E+ F QI+ A++ H I+HRDLK +N+LLD + + +KI Sbjct: 87 TLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIG 146 Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 DFG S + + T G+P Y +PEL EGK Y+ K DIW+LG VLY L F+ Sbjct: 147 DFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-QKSDIWALGCVLYELASLKRAFEA 205 Query: 194 STLQNLRARVLSGKF 208 + L L +++SG F Sbjct: 206 ANLPALVLKIMSGTF 220 >gi|1709658|sp|P53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Polo-like kinase 1) (PLK-1) (Serine-threonine protein kinase 13) (STPK13) Length = 603 Score = 117 bits (294), Expect = 2e-26 Identities = 74/254 (29%), Positives = 126/254 (49%), Gaps = 21/254 (8%) Query: 15 ETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 +TK++ A KI+ K+ L + + + K+ E+ I + L H H++ + E +++V E Sbjct: 74 DTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELC 133 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 + + + E EAR +QIV + H ++HRDLK NL L+ +L +KI Sbjct: 134 RRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIG 193 Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 DFG + + G+ KT CG+P Y APE+ K + +VD+WS+G ++Y L+ G PF+ Sbjct: 194 DFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSF-EVDVWSIGCIMYTLLVGKPPFE 252 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 S L+ R+ ++ IP K + S LI+ ML DP R Sbjct: 253 TSCLKETYLRIKKNEYSIP------------KHINPVAAS------LIQKMLQTDPTARP 294 Query: 253 SMEQICKHKWMKLG 266 ++ ++ ++ G Sbjct: 295 TINELLNDEFFTSG 308 >gi|56404656|sp|Q96RR4|KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta) Length = 588 Score = 117 bits (294), Expect = 2e-26 Identities = 72/241 (29%), Positives = 127/241 (52%), Gaps = 22/241 (9%) Query: 35 LKKIFREVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKE 92 ++++++E+ I+K L HP++++L +V++ E +Y+V E + G + + + ++E + Sbjct: 230 IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQ 288 Query: 93 ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ-LLKTWC 151 AR F+ ++ + + H + I+HRD+K NLL+ + +IKIADFG SN F LL Sbjct: 289 ARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTV 348 Query: 152 GSPPYAAPELFE--GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR 209 G+P + APE K + G +D+W++GV LY V G PF + L +++ S Sbjct: 349 GTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALE 408 Query: 210 IPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDAD 269 P P++ + LK LI ML +P R+ + +I H W+ A+ Sbjct: 409 FPD------QPDIAEDLK----------DLITRMLDKNPESRIVVPEIKLHPWVTRHGAE 452 Query: 270 P 270 P Sbjct: 453 P 453 >gi|125549|sp|P17252|KPCA_HUMAN Protein kinase C, alpha type (PKC-alpha) (PKC-A) Length = 672 Score = 117 bits (293), Expect = 3e-26 Identities = 67/203 (33%), Positives = 113/203 (55%), Gaps = 4/203 (1%) Query: 16 TKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHII-RLYQVMETERMIYLVTEYA 73 T++L AIKI+ K + +++++ E +++ +L P + +L+ +T +Y V EY Sbjct: 361 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV 420 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 +GG++ H+ G+ E +A +I ++F H R I++RDLK +N++LD+ +IKIA Sbjct: 421 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA 480 Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 DFG G +T+CG+P Y APE+ + Y G VD W+ GV+LY ++ G PFD Sbjct: 481 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-GKSVDWWAYGVLLYEMLAGQPPFD 539 Query: 193 GSTLQNLRARVLSGKFRIPFFMS 215 G L ++ P +S Sbjct: 540 GEDEDELFQSIMEHNVSYPKSLS 562 >gi|400135|sp|Q02156|KPCE_HUMAN Protein kinase C, epsilon type (nPKC-epsilon) Length = 737 Score = 116 bits (290), Expect = 6e-26 Identities = 70/245 (28%), Positives = 128/245 (52%), Gaps = 10/245 (4%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63 G ++ L+ ++ A+K++ K L ++++ E +I+ + HP++ +LY +T+ Sbjct: 420 GKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTK 479 Query: 64 RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123 ++ V EY +GG++ + + E +R ++ +A+ F H +++RDLK +N+L Sbjct: 480 DRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNIL 539 Query: 124 LDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182 LDA + K+ADFG G T+CG+P Y APE+ + EY GP VD W+LGV++Y Sbjct: 540 LDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEY-GPSVDWWALGVLMY 598 Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPEL------DKRLKAGCLSIAEC 236 ++ G PF+ +L +L P ++S V L + + GC++ Sbjct: 599 EMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNG 658 Query: 237 EHLIR 241 E I+ Sbjct: 659 EDAIK 663 >gi|3024670|sp|Q15831|STK11_HUMAN Serine/threonine-protein kinase 11 (Serine/threonine-protein kinase LKB1) Length = 433 Score = 116 bits (290), Expect = 6e-26 Identities = 82/257 (31%), Positives = 126/257 (49%), Gaps = 35/257 (13%) Query: 21 AIKIIDKTQL-----DEENLKKIFREVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYA 73 A+KI+ K +L E N+KK E+Q+++ L H ++I+L V+ E ++ +Y+V EY Sbjct: 76 AVKILKKKKLRRIPNGEANVKK---EIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYC 132 Query: 74 SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 G E+ D V R +A F Q++ + + H + IVH+D+K NLLL +K Sbjct: 133 VCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLK 191 Query: 132 IADFGFSNLFTP---GQLLKTWCGSPPYAAPELFEGKE-YDGPKVDIWSLGVVLYVLVCG 187 I+D G + P +T GSP + PE+ G + + G KVDIWS GV LY + G Sbjct: 192 ISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTG 251 Query: 188 ALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247 PF+G + L + G + IP L L++ ML + Sbjct: 252 LYPFEGDNIYKLFENIGKGSYAIPGDCGPPL------------------SDLLKGMLEYE 293 Query: 248 PNKRLSMEQICKHKWMK 264 P KR S+ QI +H W + Sbjct: 294 PAKRFSIRQIRQHSWFR 310 >gi|462455|sp|P05129|KPCG_HUMAN Protein kinase C, gamma type (PKC-gamma) Length = 697 Score = 115 bits (288), Expect = 1e-25 Identities = 62/168 (36%), Positives = 95/168 (56%), Gaps = 5/168 (2%) Query: 51 PHII-RLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC 109 PH + +L+ +T +Y V EY +GG++ H+ G+ E A +I ++F H Sbjct: 414 PHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHN 473 Query: 110 RNIVHRDLKAENLLLDANLNIKIADFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEY 167 + I++RDLK +N++LDA +IKI DFG N+F PG +T+CG+P Y APE+ + Y Sbjct: 474 QGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVF-PGTTTRTFCGTPDYIAPEIIAYQPY 532 Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMS 215 G VD WS GV+LY ++ G PFDG + L ++ P +S Sbjct: 533 -GKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLS 579 >gi|56404620|sp|Q8N5S9|KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase kinase 1 (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase) Length = 505 Score = 115 bits (287), Expect = 1e-25 Identities = 71/241 (29%), Positives = 122/241 (50%), Gaps = 22/241 (9%) Query: 35 LKKIFREVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKE 92 L+++++E+ I+K L H ++++L +V++ E +YLV + G + + + +E++ Sbjct: 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQ 251 Query: 93 ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL-LKTWC 151 AR + ++ + + HC+ IVHRD+K NLLL + ++KIADFG SN F L + Sbjct: 252 ARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTA 311 Query: 152 GSPPYAAPELF--EGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR 209 G+P + APE G+ + G +D+W+ GV LY V G PF + L ++ + Sbjct: 312 GTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVV 371 Query: 210 IPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDAD 269 P PE+ + LK LI ML +P R+ + I H W+ + Sbjct: 372 FP------EEPEISEELK----------DLILKMLDKNPETRIGVPDIKLHPWVTKNGEE 415 Query: 270 P 270 P Sbjct: 416 P 416 >gi|2499575|sp|Q15139|KPCM_HUMAN Protein kinase C, mu type (nPKC-mu) (Protein kinase D) Length = 912 Score = 115 bits (287), Expect = 1e-25 Identities = 76/256 (29%), Positives = 134/256 (52%), Gaps = 23/256 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 ++T + VAIKIIDK + + ++ EV I++ L HP ++ L + ET +++V E Sbjct: 603 RKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKL 662 Query: 74 SGGEIFDHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128 G++ + +++ GR+ E + QI+ A+ H +NIVH DLK EN+LL D Sbjct: 663 H-GDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP 721 Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188 +K+ DFGF+ + ++ G+P Y APE+ K Y+ +D+WS+GV++YV + G Sbjct: 722 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYN-RSLDMWSVGVIIYVSLSGT 780 Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248 PF+ +++ ++ + F P P K + E LI ++L + Sbjct: 781 FPFNED--EDIHDQIQNAAFMYP--------PNPWKEIS------HEAIDLINNLLQVKM 824 Query: 249 NKRLSMEQICKHKWMK 264 KR S+++ H W++ Sbjct: 825 RKRYSVDKTLSHPWLQ 840 >gi|28558166|sp|Q9HBY8|SGK2_HUMAN Serine/threonine-protein kinase Sgk2 (Serum/glucocorticoid regulated kinase 2) Length = 427 Score = 114 bits (286), Expect = 2e-25 Identities = 73/235 (31%), Positives = 116/235 (49%), Gaps = 22/235 (9%) Query: 21 AIKIIDKTQ-LDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78 A+K++ K L ++ I E ++ K + HP ++ L +T +Y V +Y +GGE+ Sbjct: 122 AVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGEL 181 Query: 79 FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF- 137 F HL R E AR ++ +A+ + H NI++RDLK EN+LLD ++ + DFG Sbjct: 182 FFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLC 241 Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ 197 P T+CG+P Y APE+ + YD VD W LG VLY ++ G PF + Sbjct: 242 KEGVEPEDTTSTFCGTPEYLAPEVLRKEPYD-RAVDWWCLGAVLYEMLHGLPPFYSQDVS 300 Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 + +L +IP G ++A C+ L++ +L D +RL Sbjct: 301 QMYENILHQPLQIP-----------------GGRTVAACD-LLQSLLHKDQRQRL 337 >gi|125379|sp|P14619|KGP1B_HUMAN cGMP-dependent protein kinase 1, beta isozyme (cGK 1 beta) (cGKI-beta) Length = 686 Score = 114 bits (285), Expect = 2e-25 Identities = 78/256 (30%), Positives = 124/256 (48%), Gaps = 23/256 (8%) Query: 15 ETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 E + A+KI+ K + D + I E QIM+ I+RLY+ + + +Y++ E Sbjct: 397 EESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEAC 456 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GGE++ L G + R +V A + H + I++RDLK ENL+LD K+ Sbjct: 457 LGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLV 516 Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 DFGF+ G+ T+CG+P Y APE+ K +D D WSLG+++Y L+ G+ PF G Sbjct: 517 DFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD-ISADYWSLGILMYELLTGSPPFSG 575 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252 +L G I E K++ +LI+ + +P++RL Sbjct: 576 PDPMKTYNIILRGIDMI----------EFPKKI------AKNAANLIKKLCRDNPSERLG 619 Query: 253 ----SMEQICKHKWMK 264 ++ I KHKW + Sbjct: 620 NLKNGVKDIQKHKWFE 635 >gi|6225588|sp|Q13976|KGP1A_HUMAN cGMP-dependent protein kinase 1, alpha isozyme (CGK 1 alpha) (cGKI-alpha) Length = 671 Score = 114 bits (285), Expect = 2e-25 Identities = 78/256 (30%), Positives = 124/256 (48%), Gaps = 23/256 (8%) Query: 15 ETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 E + A+KI+ K + D + I E QIM+ I+RLY+ + + +Y++ E Sbjct: 382 EESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEAC 441 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GGE++ L G + R +V A + H + I++RDLK ENL+LD K+ Sbjct: 442 LGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLV 501 Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 DFGF+ G+ T+CG+P Y APE+ K +D D WSLG+++Y L+ G+ PF G Sbjct: 502 DFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD-ISADYWSLGILMYELLTGSPPFSG 560 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252 +L G I E K++ +LI+ + +P++RL Sbjct: 561 PDPMKTYNIILRGIDMI----------EFPKKI------AKNAANLIKKLCRDNPSERLG 604 Query: 253 ----SMEQICKHKWMK 264 ++ I KHKW + Sbjct: 605 NLKNGVKDIQKHKWFE 620 >gi|20138711|sp|Q9BZL6|KPCD2_HUMAN Protein kinase C, D2 type (nPKC-D2) (Protein kinase D2) (HSPC187) Length = 878 Score = 113 bits (282), Expect = 5e-25 Identities = 73/256 (28%), Positives = 135/256 (52%), Gaps = 23/256 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 ++T + VA+K+IDK + + ++ EV I++ L HP I+ L + ET +++V E Sbjct: 571 RKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKL 630 Query: 74 SGGEIFDHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128 G++ + +++ GR+ E+ + QI+ A+ H +NIVH DLK EN+LL D Sbjct: 631 H-GDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP 689 Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188 +K+ DFGF+ + ++ G+P Y APE+ + Y+ +D+WS+GV++YV + G Sbjct: 690 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYN-RSLDMWSVGVIMYVSLSGT 748 Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248 PF+ +++ ++ + F P + AG + LI ++L + Sbjct: 749 FPFNED--EDINDQIQNAAFMYP--------ASPWSHISAGAID------LINNLLQVKM 792 Query: 249 NKRLSMEQICKHKWMK 264 KR S+++ H W++ Sbjct: 793 RKRYSVDKSLSHPWLQ 808 >gi|20141488|sp|P05771|KPCB_HUMAN Protein kinase C, beta type (PKC-beta) (PKC-B) Length = 671 Score = 113 bits (282), Expect = 5e-25 Identities = 66/204 (32%), Positives = 112/204 (54%), Gaps = 6/204 (2%) Query: 16 TKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHII-RLYQVMETERMIYLVTEYA 73 T +L A+KI+ K + +++++ E +++ + P + +L+ +T +Y V EY Sbjct: 364 TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYV 423 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 +GG++ H+ GR E A +I ++F + I++RDLK +N++LD+ +IKIA Sbjct: 424 NGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIA 483 Query: 134 DFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 DFG N++ G KT+CG+P Y APE+ + Y G VD W+ GV+LY ++ G PF Sbjct: 484 DFGMCKENIW-DGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPF 541 Query: 192 DGSTLQNLRARVLSGKFRIPFFMS 215 +G L ++ P MS Sbjct: 542 EGEDEDELFQSIMEHNVAYPKSMS 565 >gi|17380162|sp|O15530|PDPK1_HUMAN 3-phosphoinositide dependent protein kinase-1 (hPDK1) Length = 556 Score = 112 bits (280), Expect = 9e-25 Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 27/248 (10%) Query: 16 TKQLVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T + AIKI++K + +EN + + RE +M L HP ++LY + + +Y YA Sbjct: 104 TSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAK 163 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GE+ ++ G E R +IV+A+ + H + I+HRDLK EN+LL+ +++I+I D Sbjct: 164 NGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITD 223 Query: 135 FGFSNLFTPGQ---LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 FG + + +P ++ G+ Y +PEL K D+W+LG ++Y LV G PF Sbjct: 224 FGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS-ACKSSDLWALGCIIYQLVAGLPPF 282 Query: 192 DGSTLQNLRARVLSGKFRIP--FFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPN 249 + +++ ++ P FF + L+ +LVLD Sbjct: 283 RAGNEYLIFQKIIKLEYDFPEKFF--------------------PKARDLVEKLLVLDAT 322 Query: 250 KRLSMEQI 257 KRL E++ Sbjct: 323 KRLGCEEM 330 >gi|52000829|sp|Q8IW41|MAPK5_HUMAN MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase) Length = 473 Score = 112 bits (279), Expect = 1e-24 Identities = 92/343 (26%), Positives = 161/343 (46%), Gaps = 67/343 (19%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLC--HPHIIRLYQVMETE-------- 63 + T++ A+KI+ LD + R + M+C HP+I+++ +V Sbjct: 42 KSTQERFALKIL----LDRPKARNEVR----LHMMCATHPNIVQIIEVFANSVQFPHESS 93 Query: 64 --RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121 + +V E GGE+F + H EK+A + KQI A+ CH NI HRDLK EN Sbjct: 94 PRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPEN 153 Query: 122 LLLDAN---LNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEG-----KEYDG---- 169 LL N +K+ DFGF+ + G L+ T +P Y AP++ E KE G Sbjct: 154 LLFKDNSLDAPVKLCDFGFAKI-DQGDLM-TPQFTPYYVAPQVLEAQRRHQKEKSGIIPT 211 Query: 170 --------PKVDIWSLGVVLYVLVCGALPF-----DGSTLQNLRARVLSGKFRIPFFMST 216 D+WSLGV++YV++CG PF + +++R ++++G F P Sbjct: 212 SPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFP----- 266 Query: 217 GLVPELDKRLKAGCLSIAE-CEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRL 275 + I+E + ++R +L + P +RL++E + H W+ +A D + Sbjct: 267 ----------EEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEA---LDNV 313 Query: 276 IAECQQLKEERQVDPLNEDVLLAMEDMGL-DKEQTLQPDGTLN 317 + Q + ++ V + + + +M + D + +L+P ++N Sbjct: 314 LPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVN 356 >gi|24211884|sp|Q9H1R3|MYLK2_HUMAN Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) Length = 596 Score = 111 bits (278), Expect = 2e-24 Identities = 76/250 (30%), Positives = 120/250 (48%), Gaps = 26/250 (10%) Query: 20 VAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78 +A K+I K T D+E + E+++M L H ++I+LY +ET I L EY GGE+ Sbjct: 311 LAAKVIKKQTPKDKE---MVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGEL 367 Query: 79 FDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN--IKIADF 135 F+ +V + E + +QI + F H ++H DLK EN+L +KI DF Sbjct: 368 FERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDF 427 Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFDG 193 G + + P + LK G+P + +PE+ YD K D+WS+GV+ Y+L+ G PF G Sbjct: 428 GLARRYNPNEKLKVNFGTPEFLSPEVV---NYDQISDKTDMWSMGVITYMLLSGLSPFLG 484 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253 VLSG + +F D E + + +++V D R++ Sbjct: 485 DDDTETLNNVLSGNW---YFDEETFEAVSD-----------EAKDFVSNLIVKDQRARMN 530 Query: 254 MEQICKHKWM 263 Q H W+ Sbjct: 531 AAQCLAHPWL 540 >gi|12230239|sp|O94806|KPCN_HUMAN Protein kinase C, nu type (nPKC-nu) (Protein kinase EPK2) Length = 890 Score = 110 bits (276), Expect = 3e-24 Identities = 73/256 (28%), Positives = 134/256 (52%), Gaps = 23/256 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 ++T + VAIK+IDK + + ++ EV I++ L HP I+ L + ET +++V E Sbjct: 596 RKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKL 655 Query: 74 SGGEIFDHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128 G++ + +++ R+ E+ + QI+ A+ H +NIVH DLK EN+LL + Sbjct: 656 H-GDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFP 714 Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188 +K+ DFGF+ + ++ G+P Y APE+ K Y+ +D+WS+GV++YV + G Sbjct: 715 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYN-RSLDMWSVGVIIYVSLSGT 773 Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248 PF+ +++ ++ + F P P + + E LI ++L + Sbjct: 774 FPFNED--EDINDQIQNAAFMYP--------PNPWREIS------GEAIDLINNLLQVKM 817 Query: 249 NKRLSMEQICKHKWMK 264 KR S+++ H W++ Sbjct: 818 RKRYSVDKSLSHPWLQ 833 >gi|3041712|sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 110 bits (275), Expect = 3e-24 Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 20/249 (8%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 Q VAIK I+ + ++ L I E+ +MK L +P+I+ +++V EY +GG Sbjct: 273 QEVAIKQINLQKQPKKEL--IINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGS 330 Query: 78 IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 + D +V M E + ++ + A+ F H ++HRD+K++N+LL ++K+ DFGF Sbjct: 331 LTD-VVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGF 389 Query: 138 SNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196 TP Q + T G+P + APE+ K Y GPKVDIWSLG++ +V G P+ Sbjct: 390 CAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY----- 443 Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256 + R + ++T PEL K + + L +D KR S ++ Sbjct: 444 ------LNENPLRALYLIATNGTPELQNPEKLSPI----FRDFLNRCLEMDVEKRGSAKE 493 Query: 257 ICKHKWMKL 265 + +H ++KL Sbjct: 494 LLQHPFLKL 502 >gi|1709252|sp|P51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21) Length = 445 Score = 109 bits (273), Expect = 6e-24 Identities = 86/309 (27%), Positives = 146/309 (47%), Gaps = 22/309 (7%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQ--VMETERMIYLVTEYASG 75 +++ K +D + E + + EV +++ L HP+I+R Y + T +Y+V EY G Sbjct: 32 KILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEG 91 Query: 76 GEIFDHLVAHGR----MAEKEARRKFKQIVTAVYFCHCRN-----IVHRDLKAENLLLDA 126 G++ + + + E+ R Q+ A+ CH R+ ++HRDLK N+ LD Sbjct: 92 GDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDG 151 Query: 127 NLNIKIADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185 N+K+ DFG + + KT+ G+P Y +PE Y+ K DIWSLG +LY L Sbjct: 152 KQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYN-EKSDIWSLGCLLYELC 210 Query: 186 CGALPFDGSTLQNLRARVLSGKF-RIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244 PF + + L ++ GKF RIP+ S L + + L E ++ + L Sbjct: 211 ALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL 270 Query: 245 VLD---PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMED 301 + D +R ++E+ + +LG+ + + D + +E Q+ E L A E+ Sbjct: 271 IADLVADEQRRNLER----RGRQLGEPEKSQDSSPVLSELKLKEIQLQE-RERALKAREE 325 Query: 302 MGLDKEQTL 310 KEQ L Sbjct: 326 RLEQKEQEL 334 >gi|2499643|sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 109 bits (273), Expect = 6e-24 Identities = 76/267 (28%), Positives = 134/267 (50%), Gaps = 20/267 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T Q VAIK ++ Q ++ L I E+ +M+ +P+I+ +++V EY +G Sbjct: 292 TGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 349 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 G + D +V M E + ++ + A+ F H ++HRD+K++N+LL + ++K+ DF Sbjct: 350 GSLTD-VVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 408 Query: 136 GFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194 GF TP Q + T G+P + APE+ K Y GPKVDIWSLG++ ++ G P+ Sbjct: 409 GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMIEGEPPY--- 464 Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSM 254 + R + ++T PEL K + + L +D KR S Sbjct: 465 --------LNENPLRALYLIATNGTPELQNPEKLSAI----FRDFLNRCLDMDVEKRGSA 512 Query: 255 EQICKHKWMKLGDADPNFDRLIAECQQ 281 +++ +H+++K+ + LIA ++ Sbjct: 513 KELLQHQFLKIAKPLSSLTPLIAAAKE 539 >gi|12644418|sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth muscle and non-muscle isozymes (MLCK) [Contains: Telokin (Kinase related protein) (KRP)] Length = 1914 Score = 109 bits (273), Expect = 6e-24 Identities = 82/295 (27%), Positives = 134/295 (45%), Gaps = 27/295 (9%) Query: 31 DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHG-RMA 89 ++EN+++ E+ IM L HP +++ E + I +V E SGGE+F+ ++ + Sbjct: 1502 EKENIRQ---EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELT 1558 Query: 90 EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLL 147 E+E + +QI V + H + IVH DLK EN++ IK+ DFG + L Sbjct: 1559 ERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSL 1618 Query: 148 KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF----DGSTLQNLRARV 203 K G+P + APE+ E G D+WS+GV+ Y+LV G PF D TL N+ + Sbjct: 1619 KVLFGTPEFVAPEVI-NYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSAT 1677 Query: 204 LSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICK---- 259 +S + LK + +C ++H ++ K + +++ K Sbjct: 1678 WDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMK 1737 Query: 260 -----HKWMKLGDADPNFDRL--IAECQQLKEERQ-----VDPLNEDVLLAMEDM 302 KW K G+A RL +A L + PLN + L + ED+ Sbjct: 1738 KYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV 1792 >gi|20141582|sp|Q04759|KPCT_HUMAN Protein kinase C, theta type (nPKC-theta) Length = 706 Score = 109 bits (272), Expect = 8e-24 Identities = 93/318 (29%), Positives = 152/318 (47%), Gaps = 41/318 (12%) Query: 5 KGYIIQDFLQE---TKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQV 59 KG + FL E T Q AIK + K L +++++ E +++ + HP + ++ Sbjct: 388 KGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCT 447 Query: 60 METERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKA 119 +T+ ++ V EY +GG++ H+ + + A +I+ + F H + IV+RDLK Sbjct: 448 FQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKL 507 Query: 120 ENLLLDANLNIKIADFGFSNLFTPGQL-LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLG 178 +N+LLD + +IKIADFG G T+CG+P Y APE+ G++Y+ VD WS G Sbjct: 508 DNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYN-HSVDWWSFG 566 Query: 179 VVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH 238 V+LY ++ G PF G + L + + PF+ L+K E + Sbjct: 567 VLLYEMLIGQSPFHGQDEEELFHSI---RMDNPFYPRW-----LEK----------EAKD 608 Query: 239 LIRHMLVLDPNKRLSME-QICKH------KWMKL--GDADPNFDRLIA---ECQQLKEER 286 L+ + V +P KRL + I +H W +L + DP F + +C +E Sbjct: 609 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 668 Query: 287 QVDPLNEDVLLAMEDMGL 304 LNE L+ D L Sbjct: 669 ----LNEKPRLSFADRAL 682 >gi|60390226|sp|Q9Y2H9|MAST1_HUMAN Microtubule-associated serine/threonine-protein kinase 1 (Syntrophin-associated serine/threonine-protein kinase) Length = 1570 Score = 109 bits (272), Expect = 8e-24 Identities = 83/256 (32%), Positives = 127/256 (49%), Gaps = 33/256 (12%) Query: 14 QETKQLVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 ++T+Q A+K I+K L N +++ F E I+ +P ++ ++ ET R + +V EY Sbjct: 394 RDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEY 453 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GG+ L G + + AR F + V A+ + H IVHRDLK +NLL+ + +IK+ Sbjct: 454 VEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKL 513 Query: 133 ADFGFS---------NLF-------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176 DFG S NL+ L K CG+P Y APE+ + Y G VD W+ Sbjct: 514 TDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY-GKPVDWWA 572 Query: 177 LGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAEC 236 +G++LY + G +PF G T + L +V+S L PE D+ L E Sbjct: 573 MGIILYEFLVGCVPFFGDTPEELFGQVISDDI---------LWPEGDEALP------TEA 617 Query: 237 EHLIRHMLVLDPNKRL 252 + LI +L +P RL Sbjct: 618 QLLISSLLQTNPLVRL 633 >gi|22256934|sp|Q96PY6|NEK1_HUMAN Serine/threonine-protein kinase Nek1 (NimA-related protein kinase 1) (NY-REN-55 antigen) Length = 1258 Score = 108 bits (271), Expect = 1e-23 Identities = 61/190 (32%), Positives = 109/190 (57%), Gaps = 4/190 (2%) Query: 22 IKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDH 81 IK I+ +++ + ++ REV ++ + HP+I++ + E +Y+V +Y GG++F Sbjct: 32 IKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKR 91 Query: 82 LVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN 139 + A + E + F QI A+ H R I+HRD+K++N+ L + +++ DFG + Sbjct: 92 INAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIAR 151 Query: 140 -LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 198 L + +L +T G+P Y +PE+ E K Y+ K DIW+LG VLY L F+ +++N Sbjct: 152 VLNSTVELARTCIGTPYYLSPEICENKPYNN-KSDIWALGCVLYELCTLKHAFEAGSMKN 210 Query: 199 LRARVLSGKF 208 L +++SG F Sbjct: 211 LVLKIISGSF 220 >gi|3914977|sp|O00141|SGK1_HUMAN Serine/threonine-protein kinase Sgk1 (Serum/glucocorticoid-regulated kinase 1) Length = 431 Score = 108 bits (271), Expect = 1e-23 Identities = 89/299 (29%), Positives = 135/299 (45%), Gaps = 37/299 (12%) Query: 21 AIKIIDKTQ-LDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78 A+K++ K L ++ K I E ++ K + HP ++ L+ +T +Y V +Y +GGE+ Sbjct: 125 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 184 Query: 79 FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF- 137 F HL E AR +I +A+ + H NIV+RDLK EN+LLD+ +I + DFG Sbjct: 185 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLC 244 Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ 197 T+CG+P Y APE+ + YD VD W LG VLY ++ G PF Sbjct: 245 KENIEHNSTTSTFCGTPEYLAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTA 303 Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME-- 255 + +L+ + L P + HL+ +L D KRL + Sbjct: 304 EMYDNILNKPLQ--------LKPNITN----------SARHLLEGLLQKDRTKRLGAKDD 345 Query: 256 --QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQP 312 +I H + L N+D LI ++ P N +V E D E T +P Sbjct: 346 FMEIKSHVFFSL----INWDDLI-------NKKITPPFNPNVSGPNELRHFDPEFTEEP 393 >gi|56405369|sp|Q00532|KKIA_HUMAN Serine/threonine-protein kinase KKIALRE (Cyclin-dependent kinase-like 1) Length = 358 Score = 108 bits (271), Expect = 1e-23 Identities = 84/272 (30%), Positives = 136/272 (50%), Gaps = 28/272 (10%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 ++T Q+VAIK +++ D+ +KKI RE++++K L HP+++ L +V +R ++LV EY Sbjct: 25 RDTGQIVAIKKFLESE-DDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEY 83 Query: 73 ASGGEIFDHLVAHGR------MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA 126 DH V H + E + Q + AV FCH N +HRD+K EN+L+ Sbjct: 84 C------DHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITK 137 Query: 127 NLNIKIADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185 + IK+ DFGF+ L T P + + Y +PEL G GP VD+W++G V L+ Sbjct: 138 HSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELL 197 Query: 186 CGALPFDG-----------STLQNLRARVLSGKFRIPFFMSTGLV-PELDKRLKAGCLSI 233 G + G TL +L R +F + PE + L+ +I Sbjct: 198 SGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNI 257 Query: 234 A-ECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 + L++ L +DP +RL+ EQ+ H + + Sbjct: 258 SYPALGLLKGCLHMDPTERLTCEQLLHHPYFE 289 >gi|6225859|sp|Q16513|PKL2_HUMAN Protein kinase N2 (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) Length = 984 Score = 108 bits (270), Expect = 1e-23 Identities = 81/284 (28%), Positives = 134/284 (47%), Gaps = 36/284 (12%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQL---DEENL----KKIFREVQIMKMLCHPHIIRLYQ 58 G ++ + T ++ AIK + K + DE + K+IF V ++ HP ++ L+ Sbjct: 669 GKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR---HPFLVNLFA 725 Query: 59 VMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLK 118 +T+ + V EYA+GG++ H+ +E A +V + + H IV+RDLK Sbjct: 726 CFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQYLHEHKIVYRDLK 784 Query: 119 AENLLLDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSL 177 +NLLLD +KIADFG G T+CG+P + APE+ Y VD W L Sbjct: 785 LDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYT-RAVDWWGL 843 Query: 178 GVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECE 237 GV++Y ++ G PF G + + +++ + R P F+ST E Sbjct: 844 GVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLST------------------EAI 885 Query: 238 HLIRHMLVLDPNKRL-----SMEQICKHKWMKLGDADPNFDRLI 276 ++R +L +P +RL E + KH + +L D D+ + Sbjct: 886 SIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKV 929 >gi|38502964|sp|Q86V86|PIM3_HUMAN Serine/threonine-protein kinase Pim-3 Length = 326 Score = 107 bits (268), Expect = 2e-23 Identities = 73/213 (34%), Positives = 102/213 (47%), Gaps = 27/213 (12%) Query: 53 IIRLYQVMETERMIYLVTEYASGGE-IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 111 +IRL E LV E + +FD + G + E ARR F Q++ AV CH Sbjct: 106 VIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCG 165 Query: 112 IVHRDLKAENLLLDANL-NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 170 +VHRD+K ENLL+D +K+ DFG S + + G+ Y+ PE Y G Sbjct: 166 VVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGR 224 Query: 171 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGC 230 +WSLGV+LY +VCG +PF+ + LR R+L + P Sbjct: 225 SATVWSLGVLLYDMVCGDIPFEQDE-EILRGRLLFRRRVSP------------------- 264 Query: 231 LSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263 EC+ LIR L L P++R S++QI H WM Sbjct: 265 ----ECQQLIRWCLSLRPSERPSLDQIAAHPWM 293 >gi|54041234|sp|P23443|KS6B1_HUMAN Ribosomal protein S6 kinase 1 (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (p70-alpha) Length = 525 Score = 107 bits (267), Expect = 3e-23 Identities = 67/220 (30%), Positives = 112/220 (50%), Gaps = 4/220 (1%) Query: 16 TKQLVAIKIIDKTQL--DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 T ++ A+K++ K + + ++ E I++ + HP I+ L +T +YL+ EY Sbjct: 116 TGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYL 175 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 SGGE+F L G E A +I A+ H + I++RDLK EN++L+ ++K+ Sbjct: 176 SGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLT 235 Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 DFG G + T+CG+ Y APE+ ++ VD WSLG ++Y ++ GA PF Sbjct: 236 DFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHN-RAVDWWSLGALMYDMLTGAPPFT 294 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLS 232 G + ++L K +P +++ L K LK S Sbjct: 295 GENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAAS 334 >gi|14423909|sp|O94768|ST17B_HUMAN Serine/threonine-protein kinase 17B (DAP kinase-related apoptosis-inducing protein kinase 2) Length = 372 Score = 107 bits (266), Expect = 4e-23 Identities = 79/268 (29%), Positives = 127/268 (47%), Gaps = 27/268 (10%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH-PHIIRLYQVMETERMIYLVTEY 72 + T Q A K + K + ++ +I E+ ++++ P +I L++V E I L+ EY Sbjct: 53 KSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEY 112 Query: 73 ASGGEIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL-- 128 A+GGEIF + ++E + R KQI+ VY+ H NIVH DLK +N+LL + Sbjct: 113 AAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPL 172 Query: 129 -NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLV 185 +IKI DFG S L+ G+P Y APE+ YD D+W++G++ Y+L+ Sbjct: 173 GDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL---NYDPITTATDMWNIGIIAYMLL 229 Query: 186 CGALPFDGSTLQNLRARVLSGKFRIPFFMST-GLVPELDKRLKAGCLSIAECEHLIRHML 244 PF G Q + + + + T V +L I+ +L Sbjct: 230 THTSPFVGEDNQETYLNI--SQVNVDYSEETFSSVSQL-------------ATDFIQSLL 274 Query: 245 VLDPNKRLSMEQICKHKWMKLGDADPNF 272 V +P KR + E H W++ D + F Sbjct: 275 VKNPEKRPTAEICLSHSWLQQWDFENLF 302 >gi|12643872|sp|Q9UBS0|KS6B2_HUMAN Ribosomal protein S6 kinase 2 (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta) Length = 482 Score = 107 bits (266), Expect = 4e-23 Identities = 63/213 (29%), Positives = 111/213 (52%), Gaps = 4/213 (1%) Query: 18 QLVAIKIIDKTQL--DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 ++ A+K++ K ++ + ++ E I++ + HP I+ L +T +YL+ E SG Sbjct: 94 KIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSG 153 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 GE+F HL G E A +I A+ H + I++RDLK EN++L + +IK+ DF Sbjct: 154 GELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDF 213 Query: 136 GF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194 G G + T+CG+ Y APE+ ++ VD WSLG ++Y ++ G+ PF Sbjct: 214 GLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHN-RAVDWWSLGALMYDMLTGSPPFTAE 272 Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLK 227 + +++ GK +P +++ + K LK Sbjct: 273 NRKKTMDKIIRGKLALPPYLTPDARDLVKKFLK 305 >gi|125565|sp|P11309|PIM1_HUMAN Proto-oncogene serine/threonine-protein kinase Pim-1 Length = 313 Score = 106 bits (265), Expect = 5e-23 Identities = 78/253 (30%), Positives = 125/253 (49%), Gaps = 33/253 (13%) Query: 20 VAIKIIDKTQLDE----ENLKKIFREVQIMKMLCHPH--IIRLYQVMETERMIYLVTEYA 73 VAIK ++K ++ + N ++ EV ++K + +IRL E L+ E Sbjct: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 Query: 74 SG-GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL-NIK 131 ++FD + G + E+ AR F Q++ AV CH ++HRD+K EN+L+D N +K Sbjct: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183 Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 + DFG S + + G+ Y+ PE Y G +WSLG++LY +VCG +PF Sbjct: 184 LIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 + + +R +V FR +R+ +EC+HLIR L L P+ R Sbjct: 243 EHDE-EIIRGQVF---FR--------------QRVS------SECQHLIRWCLALRPSDR 278 Query: 252 LSMEQICKHKWMK 264 + E+I H WM+ Sbjct: 279 PTFEEIQNHPWMQ 291 >gi|47117818|sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 106 bits (264), Expect = 6e-23 Identities = 74/251 (29%), Positives = 128/251 (50%), Gaps = 20/251 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T Q VAIK ++ Q ++ L I E+ +M+ +P+I+ +++V EY +G Sbjct: 305 TGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 G + D +V M E + ++ + A+ F H ++HRD+K++N+LL + ++K+ DF Sbjct: 363 GSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421 Query: 136 GFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194 GF TP Q + T G+P + APE+ K Y GPKVDIWSLG++ +V G P+ Sbjct: 422 GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY--- 477 Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSM 254 + R + ++T PEL + A + L +D ++R S Sbjct: 478 --------LNENPLRALYLIATNGTPELQNPERLS----AVFRDFLNRCLEMDVDRRGSA 525 Query: 255 EQICKHKWMKL 265 +++ +H ++KL Sbjct: 526 KELLQHPFLKL 536 >gi|8928460|sp|O75962|TRIO_HUMAN Triple functional domain protein (PTPRF interacting protein) Length = 3038 Score = 105 bits (262), Expect = 1e-22 Identities = 77/283 (27%), Positives = 129/283 (45%), Gaps = 25/283 (8%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 TK+ VA K ++K + + ++ E+ I++ L HP ++ L ET LV E A Sbjct: 2759 TKRAVATKFVNKKLMKRD---QVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQ 2815 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKI 132 G + D +V G + E + R +++ AV + H I H DLK EN+L+D +L IK+ Sbjct: 2816 GRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKL 2875 Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 ADFG + + G+P +AAPE+ G D WS+GV+ YVL+ G PF Sbjct: 2876 ADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTS-DTWSVGVLTYVLLSGVSPFL 2934 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 +++ + F P G+ + + + +L DP KR Sbjct: 2935 DDSVEETCLNICRLDFSFPDDYFKGV--------------SQKAKEFVCFLLQEDPAKRP 2980 Query: 253 SMEQICKHKWMKLGDADP----NFDRLIAECQQLKEERQVDPL 291 S + +W++ G+ + RL + ++ K + V P+ Sbjct: 2981 SAALALQEQWLQAGNGRSTGVLDTSRLTSFIERRKHQNDVRPI 3023 >gi|20139243|sp|Q9P1W9|PIM2_HUMAN Serine/threonine-protein kinase Pim-2 (Pim-2h) Length = 311 Score = 104 bits (259), Expect = 2e-22 Identities = 67/217 (30%), Positives = 101/217 (46%), Gaps = 27/217 (12%) Query: 50 HPHIIRLYQVMETERMIYLVTEYA-SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 108 HP +IRL ET+ LV E ++FD++ G + E +R F Q+V A+ CH Sbjct: 96 HPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCH 155 Query: 109 CRNIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY 167 R +VHRD+K EN+L+D K+ DFG S + + G+ Y+ PE +Y Sbjct: 156 SRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPPEWISRHQY 214 Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLK 227 +WSLG++LY +VCG +PF+ +L + P +S Sbjct: 215 HALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVS------------ 256 Query: 228 AGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 +C LIR L P+ R S+E+I WM+ Sbjct: 257 ------PDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 287 >gi|28558163|sp|Q96BR1|SGK3_HUMAN Serine/threonine-protein kinase Sgk3 (Serum/glucocorticoid regulated kinase 3) (Serum/glucocorticoid regulated kinase-like) Length = 496 Score = 104 bits (259), Expect = 2e-22 Identities = 61/174 (35%), Positives = 94/174 (54%), Gaps = 4/174 (2%) Query: 21 AIKIIDKT-QLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78 A+K++ K L+ + K I E ++ K + HP ++ L+ +T +Y V ++ +GGE+ Sbjct: 189 AVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGEL 248 Query: 79 FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF- 137 F HL E AR +I +A+ + H IV+RDLK EN+LLD+ ++ + DFG Sbjct: 249 FFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLC 308 Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 T+CG+P Y APE+ + YD VD W LG VLY ++ G PF Sbjct: 309 KEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN-TVDWWCLGAVLYEMLYGLPPF 361 >gi|47605999|sp|Q13464|ROCK1_HUMAN Rho-associated protein kinase 1 (Rho-associated, coiled-coil containing protein kinase 1) (p160 ROCK-1) (p160ROCK) Length = 1354 Score = 103 bits (257), Expect = 4e-22 Identities = 60/205 (29%), Positives = 115/205 (56%), Gaps = 7/205 (3%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 + T+++ A+K++ K ++ + + F E IM P +++L+ + +R +Y+V EY Sbjct: 96 KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEY 155 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GG++ + L+++ + EK AR ++V A+ H +HRD+K +N+LLD + ++K+ Sbjct: 156 MPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKL 214 Query: 133 ADFGFSNLFTPGQLLK--TWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCG 187 ADFG +++ T G+P Y +PE+ + G Y G + D WS+GV LY ++ G Sbjct: 215 ADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVG 274 Query: 188 ALPFDGSTLQNLRARVLSGKFRIPF 212 PF +L +++++ K + F Sbjct: 275 DTPFYADSLVGTYSKIMNHKNSLTF 299 >gi|13626607|sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 102 bits (254), Expect = 9e-22 Identities = 82/321 (25%), Positives = 149/321 (46%), Gaps = 34/321 (10%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + + T+++VAIKIID + ++E ++ I +E+ ++ P++ + Y + Sbjct: 48 GEVFKGIDNRTQKVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKDTK 106 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125 ++++ EY GG D L+ G + E + ++I+ + + H +HRD+KA N+LL Sbjct: 107 LWIIMEYLGGGSALD-LLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS 165 Query: 126 ANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184 + +K+ADFG + T Q+ + T+ G+P + APE+ + YD K DIWSLG+ L Sbjct: 166 EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS-KADIWSLGITAIEL 224 Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244 G P S L ++ F IP L K LK + L Sbjct: 225 ARGEPPH--SELHPMKV-----LFLIPKNNPPTLEGNYSKPLK----------EFVEACL 267 Query: 245 VLDPNKRLSMEQICKHKWMKLGDADPNF-DRLIAECQQLKEERQVDPLNEDVLLAMEDMG 303 +P+ R + +++ KHK++ ++ LI ++ K E+ D + + Sbjct: 268 NKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSE--------- 318 Query: 304 LDKEQTLQPDGTLNLDSDEGE 324 + + DG + SD G+ Sbjct: 319 ---DSDAETDGQASGGSDSGD 336 >gi|12643529|sp|O00506|STK25_HUMAN Serine/threonine-protein kinase 25 (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase-1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 102 bits (254), Expect = 9e-22 Identities = 75/259 (28%), Positives = 124/259 (47%), Gaps = 21/259 (8%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + + TK++VAIKIID + ++E ++ I +E+ ++ P+I R + Sbjct: 32 GEVYKGIDNHTKEVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYITRYFGSYLKSTK 90 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125 ++++ EY GG D L+ G + E ++I+ + + H +HRD+KA N+LL Sbjct: 91 LWIIMEYLGGGSALD-LLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLS 149 Query: 126 ANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184 ++K+ADFG + T Q+ + T+ G+P + APE+ + YD K DIWSLG+ L Sbjct: 150 EQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF-KADIWSLGITAIEL 208 Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244 G P S L +R L K P P K CL+ Sbjct: 209 AKGEPP--NSDLHPMRVLFLIPKNSPPTLEGQHSKP--FKEFVEACLN------------ 252 Query: 245 VLDPNKRLSMEQICKHKWM 263 DP R + +++ KHK++ Sbjct: 253 -KDPRFRPTAKELLKHKFI 270 >gi|6174910|sp|Q16512|PKL1_HUMAN Protein kinase N1 (Protein kinase C-like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) Length = 942 Score = 102 bits (254), Expect = 9e-22 Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 25/256 (9%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLC---HPHIIRLYQVME 61 G ++ + + +L AIK + K + + ++ + E +I+ + HP ++ L+ + Sbjct: 627 GKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQ 686 Query: 62 TERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121 T + V EY++GG++ H+ + +E A +V + F H IV+RDLK +N Sbjct: 687 TPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDN 745 Query: 122 LLLDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV 180 LLLD +KIADFG G T+CG+P + APE+ Y VD W LGV+ Sbjct: 746 LLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYT-RAVDWWGLGVL 804 Query: 181 LYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLI 240 LY ++ G PF G + + +++ + R P F+S AE ++ Sbjct: 805 LYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS------------------AEAIGIM 846 Query: 241 RHMLVLDPNKRLSMEQ 256 R +L +P +RL + Sbjct: 847 RRLLRRNPERRLGSSE 862 >gi|547803|sp|Q05655|KPCD_HUMAN Protein kinase C, delta type (nPKC-delta) Length = 676 Score = 102 bits (254), Expect = 9e-22 Identities = 62/192 (32%), Positives = 107/192 (55%), Gaps = 6/192 (3%) Query: 6 GYIIQDFLQETKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63 G ++ L+ + AIK + K L +++++ E +++ + +P + L +T+ Sbjct: 361 GKVLLGELKGRGEYSAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420 Query: 64 RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123 ++ V E+ +GG++ H+ GR A +I+ + F H + I++RDLK +N+L Sbjct: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480 Query: 124 LDANLNIKIADFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL 181 LD + +IKIADFG N+F + T+CG+P Y APE+ +G +Y VD WS GV+L Sbjct: 481 LDRDGHIKIADFGMCKENIFGESR-ASTFCGTPDYIAPEILQGLKYTF-SVDWWSFGVLL 538 Query: 182 YVLVCGALPFDG 193 Y ++ G PF G Sbjct: 539 YEMLIGQSPFHG 550 >gi|30316125|sp|Q9HBH9|MKNK2_HUMAN MAP kinase-interacting serine/threonine kinase 2 (MAP kinase signal-integrating kinase 2) (Mnk2) Length = 418 Score = 102 bits (253), Expect = 1e-21 Identities = 91/283 (32%), Positives = 130/283 (45%), Gaps = 53/283 (18%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T Q A+KII+K + ++FREV+++ + H +++ L + E E YLV E Sbjct: 59 TSQEYAVKIIEKQPGHIRS--RVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMR 116 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IK 131 GG I H+ E EA + + +A+ F H + I HRDLK EN+L + +K Sbjct: 117 GGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVK 176 Query: 132 IADFGF----------SNLFTPGQLLKTWCGSPPYAAPELF-----EGKEYDGPKVDIWS 176 I DF S + TP L T CGS Y APE+ E YD + D+WS Sbjct: 177 ICDFDLGSGIKLNGDCSPISTPE--LLTPCGSAEYMAPEVVEAFSEEASIYD-KRCDLWS 233 Query: 177 LGVVLYVLVCGALPFDG--------------STLQN-LRARVLSGKFRIPFFMSTGLVPE 221 LGV+LY+L+ G PF G QN L + GK+ P Sbjct: 234 LGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFP---------- 283 Query: 222 LDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 DK +S A + LI +LV D +RLS Q+ +H W++ Sbjct: 284 -DK--DWAHISCA-AKDLISKLLVRDAKQRLSAAQVLQHPWVQ 322 >gi|12585288|sp|O96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (p21-activated kinase 4) (PAK-4) Length = 591 Score = 100 bits (250), Expect = 3e-21 Identities = 69/253 (27%), Positives = 129/253 (50%), Gaps = 22/253 (8%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 ++ + +LVA+K +D + L +F EV IM+ H +++ +Y +++V E+ Sbjct: 340 VRSSGKLVAVKKMDLRKQQRREL--LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEF 397 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GG + D +V H RM E++ ++ A+ H + ++HRD+K++++LL + +K+ Sbjct: 398 LEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKL 456 Query: 133 ADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 +DFGF + + K+ G+P + APEL Y GP+VDIWSLG+++ +V G P+ Sbjct: 457 SDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPY 515 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPE-LDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 F P + ++ + L RLK + + +LV DP + Sbjct: 516 ----------------FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 559 Query: 251 RLSMEQICKHKWM 263 R + ++ KH ++ Sbjct: 560 RATAAELLKHPFL 572 >gi|231726|sp|Q00526|CDK3_HUMAN Cell division protein kinase 3 Length = 305 Score = 100 bits (248), Expect = 5e-21 Identities = 82/285 (28%), Positives = 134/285 (47%), Gaps = 43/285 (15%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 +ET QLVA+K I + L+ E + RE+ ++K L HP+I+RL V+ ER +YLV E+ Sbjct: 24 RETGQLVALKKI-RLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEF 82 Query: 73 AS-----------GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121 S G E+ HL+ + Q++ V FCH ++HRDLK +N Sbjct: 83 LSQDLKKYMDSTPGSELPLHLI----------KSYLFQLLQGVSFCHSHRVIHRDLKPQN 132 Query: 122 LLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPP---YAAPELFEGKEYDGPKVDIWSLG 178 LL++ IK+ADFG + F G L+T+ Y APE+ G ++ VDIWS+G Sbjct: 133 LLINELGAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIG 190 Query: 179 VVLYVLVCGALPFDGSTLQNLRARVL-----------SGKFRIPFFMSTGLVPELDKRLK 227 + +V F G + + R+ G ++P + G P+ ++ Sbjct: 191 CIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDY--KGSFPKWTRKGL 248 Query: 228 AGCLSIAECE--HLIRHMLVLDPNKRLSMEQICKHKWMKLGDADP 270 + E E L+ +L DP++R++ + H + + P Sbjct: 249 EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSP 293 >gi|20178297|sp|P51956|NEK3_HUMAN Serine/threonine-protein kinase Nek3 (NimA-related protein kinase 3) (HSPK 36) Length = 506 Score = 99.4 bits (246), Expect = 8e-21 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 5/196 (2%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 + + Q+ A+K I + N + +E ++ + HP+I+ + E E +Y+V EY Sbjct: 24 ESSNQMFAMKEI-RLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYC 82 Query: 74 SGGEIFDHLVAH-GRM-AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 GG++ + G++ E F Q+ V H + ++HRD+K++N+ L N +K Sbjct: 83 DGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVK 142 Query: 132 IADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 + DFG + L + P T+ G+P Y PE++E Y+ K DIWSLG +LY L P Sbjct: 143 LGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN-KSDIWSLGCILYELCTLKHP 201 Query: 191 FDGSTLQNLRARVLSG 206 F ++ +NL +V G Sbjct: 202 FQANSWKNLILKVCQG 217 >gi|12585290|sp|Q9P286|PAK7_HUMAN Serine/threonine-protein kinase PAK 7 (p21-activated kinase 7) (PAK-7) (PAK-5) Length = 719 Score = 98.2 bits (243), Expect = 2e-20 Identities = 69/254 (27%), Positives = 131/254 (51%), Gaps = 22/254 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 + T + VA+K +D + L +F EV IM+ H +++ +Y +++V E+ Sbjct: 469 KHTGKQVAVKKMDLRKQQRREL--LFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFL 526 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GG + D +V H RM E++ ++ A+ + H + ++HRD+K++++LL ++ IK++ Sbjct: 527 EGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585 Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP-F 191 DFGF + + K+ G+P + APE+ Y G +VDIWSLG+++ ++ G P F Sbjct: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWSLGIMVIEMIDGEPPYF 644 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 + LQ +R + L P + K + + MLV +P++R Sbjct: 645 NEPPLQAMRR------------IRDSLPPRVKDLHKVSSV----LRGFLDLMLVREPSQR 688 Query: 252 LSMEQICKHKWMKL 265 + +++ H ++KL Sbjct: 689 ATAQELLGHPFLKL 702 >gi|6175070|sp|O76039|CDKL5_HUMAN Serine/threonine-protein kinase 9 (Cyclin-dependent kinase-like 5) Length = 1030 Score = 97.1 bits (240), Expect = 4e-20 Identities = 79/274 (28%), Positives = 135/274 (49%), Gaps = 23/274 (8%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G +++ +ET ++VAIK ++ +EE + RE+++++ L +I+ L + Sbjct: 25 GVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGK 84 Query: 66 IYLVTEYASGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123 +YLV EY E+ + + +G EK + Q++ A+++CH +IVHRD+K ENLL Sbjct: 85 LYLVFEYVEKNMLELLEEM-PNGVPPEK-VKSYIYQLIKAIHWCHKNDIVHRDIKPENLL 142 Query: 124 LDANLNIKIADFGFSNLFTPGQLLK--TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL 181 + N +K+ DFGF+ + G + + Y +PEL G Y G VD+WS+G +L Sbjct: 143 ISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPY-GKSVDMWSVGCIL 201 Query: 182 YVLVCGALPFDGS-------TLQNLRARVLSGKFRI----PFFMSTGLV----PELDKRL 226 L G F G T+Q + + S + ++ P F P+ +R Sbjct: 202 GELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERR 261 Query: 227 KAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKH 260 G L+ + L++++L LDP R EQ H Sbjct: 262 YLGILNSVLLD-LMKNLLKLDPADRYLTEQCLNH 294 >gi|1705489|sp|P51813|BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 96.7 bits (239), Expect = 5e-20 Identities = 71/270 (26%), Positives = 127/270 (47%), Gaps = 43/270 (15%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K+I + + E+ + F+E Q M L HP +++ Y V E IY+VTEY S G + Sbjct: 442 VAVKMIKEGSMSED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLL 498 Query: 80 DHLVAHGRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 ++L +HG+ E + + + F +HRDL A N L+D +L +K++DFG + Sbjct: 499 NYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMT 558 Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195 Q + + P ++APE+F +Y K D+W+ G++++ V G P+D Sbjct: 559 RYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSS-KSDVWAFGILMWEVFSLGKQPYD--- 614 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255 + ++ +V L +++ L R L D ++ Sbjct: 615 ----------------LYDNSQVV-----------LKVSQGHRLYRPHLASD-----TIY 642 Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEE 285 QI W +L + P F +L++ + L+E+ Sbjct: 643 QIMYSCWHELPEKRPTFQQLLSSIEPLREK 672 >gi|47605963|sp|O75116|ROCK2_HUMAN Rho-associated protein kinase 2 (Rho-associated, coiled-coil containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2) Length = 1388 Score = 96.7 bits (239), Expect = 5e-20 Identities = 57/203 (28%), Positives = 113/203 (55%), Gaps = 7/203 (3%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 ++++ A+K++ K ++ + + F E IM P +++L+ + +R +Y+V EY Sbjct: 114 SQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMP 173 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GG++ + L+++ + EK A+ ++V A+ H ++HRD+K +N+LLD + ++K+AD Sbjct: 174 GGDLVN-LMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLAD 232 Query: 135 FGFSNLFTPGQLL--KTWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCGAL 189 FG ++ T G+P Y +PE+ + G + G + D WS+GV LY ++ G Sbjct: 233 FGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDT 292 Query: 190 PFDGSTLQNLRARVLSGKFRIPF 212 PF +L ++++ K + F Sbjct: 293 PFYADSLVGTYSKIMDHKNSLCF 315 >gi|34098605|sp|Q8TD19|NEK9_HUMAN Serine/threonine-protein kinase Nek9 (NimA-related protein kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8) Length = 979 Score = 95.1 bits (235), Expect = 1e-19 Identities = 61/195 (31%), Positives = 104/195 (53%), Gaps = 4/195 (2%) Query: 15 ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 E LV K +D T+L E+ + E+ I+ +L H +II Y + + EY + Sbjct: 73 EDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCN 132 Query: 75 GGEIFDHLVAH-GRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GG ++D ++ ++ E+E + QIV+AV H I+HRD+K N+ L IK+ Sbjct: 133 GGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKL 192 Query: 133 ADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 D+G + L + + +T G+P Y +PEL +G +Y+ K DIW++G V++ L+ F Sbjct: 193 GDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF-KSDIWAVGCVIFELLTLKRTF 251 Query: 192 DGSTLQNLRARVLSG 206 D + NL +++ G Sbjct: 252 DATNPLNLCVKIVQG 266 >gi|2499640|sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 95.1 bits (235), Expect = 1e-19 Identities = 51/157 (32%), Positives = 87/157 (55%), Gaps = 7/157 (4%) Query: 41 EVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK 98 E+Q++K L H I++ Y + E+ + + EY GG + D L A+G + E R+ + Sbjct: 412 EIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR 471 Query: 99 QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS----NLFTPGQLLKTWCGSP 154 QI+ + + H IVHRD+K N+L D+ N+K+ DFG S + G +++ G+P Sbjct: 472 QILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTP 531 Query: 155 PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 + +PE+ G+ Y G K D+WSLG + ++ P+ Sbjct: 532 YWMSPEVISGEGY-GRKADVWSLGCTVVEMLTEKPPW 567 >gi|4033704|sp|Q00535|CDK5_HUMAN Cell division protein kinase 5 (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) Length = 292 Score = 94.7 bits (234), Expect = 2e-19 Identities = 66/264 (25%), Positives = 126/264 (47%), Gaps = 17/264 (6%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 +ET ++VA+K + DE RE+ ++K L H +I+RL+ V+ +++ + LV E+ Sbjct: 24 RETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFC 83 Query: 74 SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 + FD +G + + + Q++ + FCH RN++HRDLK +NLL++ N +K Sbjct: 84 DQDLKKYFDS--CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELK 141 Query: 132 IADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 +ADFG + F P + + Y P++ G + +D+WS G + L P Sbjct: 142 LADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRP 201 Query: 191 -FDGSTLQNLRARVL-----------SGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH 238 F G+ + + R+ ++P + + P + A Sbjct: 202 LFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRD 261 Query: 239 LIRHMLVLDPNKRLSMEQICKHKW 262 L++++L +P +R+S E+ +H + Sbjct: 262 LLQNLLKCNPVQRISAEEALQHPY 285 >gi|115922|sp|P06493|CDC2_HUMAN Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 94.7 bits (234), Expect = 2e-19 Identities = 76/275 (27%), Positives = 126/275 (45%), Gaps = 22/275 (8%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + + + T Q+VA+K I +E RE+ ++K L HP+I+ L V+ + Sbjct: 16 GVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSR 75 Query: 66 IYLVTEYASGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123 +YL+ E+ S + D + M + QI+ + FCH R ++HRDLK +NLL Sbjct: 76 LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLL 135 Query: 124 LDANLNIKIADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182 +D IK+ADFG + F P ++ + Y +PE+ G VDIWS+G + Sbjct: 136 IDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFA 195 Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDK---------RLKAGCLS- 232 L F G + + R+ FR + + PE++ + K G L+ Sbjct: 196 ELATKKPLFHGDSEIDQLFRI----FRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS 251 Query: 233 -IAECEH----LIRHMLVLDPNKRLSMEQICKHKW 262 + + L+ ML+ DP KR+S + H + Sbjct: 252 HVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 >gi|6685620|sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 618 Score = 94.7 bits (234), Expect = 2e-19 Identities = 51/157 (32%), Positives = 86/157 (54%), Gaps = 7/157 (4%) Query: 41 EVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK 98 E+Q++K H I++ Y + E+ + + EY GG I D L A+G + E R+ + Sbjct: 405 EIQLLKNFLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTR 464 Query: 99 QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS----NLFTPGQLLKTWCGSP 154 QI+ V++ H I+HRD+K N+L D+ N+K+ DFG S + G +K+ G+P Sbjct: 465 QILEGVHYLHSNMILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTP 524 Query: 155 PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 + +PE+ G+ Y G K DIWS+ + ++ P+ Sbjct: 525 YWMSPEVISGQGY-GRKADIWSVACTVVEMLTEKPPW 560 >gi|6685621|sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 94.4 bits (233), Expect = 3e-19 Identities = 76/259 (29%), Positives = 122/259 (47%), Gaps = 27/259 (10%) Query: 15 ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 +T +L+A+K I D + +K+ E++I + + HP+++R + V +Y+ EY Sbjct: 1363 DTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCD 1422 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 G + + V+ + E R KQI A+ H IVHRD+K N+ L ++ IK+ D Sbjct: 1423 EGTLEE--VSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD 1480 Query: 135 FGFS-----NLFT-PGQLLKTWCGSPPYAAPELFEGK--EYDGPKVDIWSLGVVLYVLVC 186 FG S N T PG++ T G+ Y APE+ E G DIWSLG V+ +V Sbjct: 1481 FGCSVKLKNNAQTMPGEVNST-LGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT 1539 Query: 187 GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246 G P+ F+I + + G P + +RL E + + H L Sbjct: 1540 GKRPW----------HEYEHNFQIMYKVGMGHKPPIPERLS------PEGKDFLSHCLES 1583 Query: 247 DPNKRLSMEQICKHKWMKL 265 DP R + Q+ H ++K+ Sbjct: 1584 DPKMRWTASQLLDHSFVKV 1602 >gi|12643825|sp|Q9NYV4|CD2L7_HUMAN Cell division cycle 2-related protein kinase 7 (CDC2-related protein kinase 7) (CrkRS) Length = 1490 Score = 94.0 bits (232), Expect = 3e-19 Identities = 77/290 (26%), Positives = 135/290 (46%), Gaps = 54/290 (18%) Query: 14 QETKQLVAIKIIDKTQLDEENLK---KIFREVQIMKMLCHPHIIRLYQVMETER------ 64 ++T +LVA+K K +LD E RE++I++ L H ++ + +++ ++ Sbjct: 747 KDTGELVALK---KVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFK 803 Query: 65 ----MIYLVTEYASGGEIFDH----LVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVH 114 YLV EY DH L+ G +E + KQ++ + +CH +N +H Sbjct: 804 KDKGAFYLVFEY------MDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLH 857 Query: 115 RDLKAENLLLDANLNIKIADFGFSNLFT-------PGQLLKTWCGSPPYAAPELFEGKEY 167 RD+K N+LL+ + IK+ADFG + L+ +++ W Y PEL G+E Sbjct: 858 RDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW-----YRPPELLLGEER 912 Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLS------------GKFRIPFFMS 215 P +D+WS G +L L P + L+ + ++S ++P+F + Sbjct: 913 YTPAIDVWSCGCILGELFT-KKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNT 971 Query: 216 TGLVPELDKRLKAGCLSIAECE-HLIRHMLVLDPNKRLSMEQICKHKWMK 264 + +RL+ I L+ HML LDP+KR + EQ + ++K Sbjct: 972 MKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 1021 >gi|3915762|sp|P53667|LIK1_HUMAN LIM domain kinase 1 (LIMK-1) Length = 647 Score = 93.6 bits (231), Expect = 4e-19 Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 19/196 (9%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G I+ +ET +++ +K + + DEE + +EV++M+ L HP++++ V+ ++ Sbjct: 351 GQAIKVTHRETGEVMVMK--ELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKR 408 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLL 124 + +TEY GG + + + R F K I + + + H NI+HRDL + N L+ Sbjct: 409 LNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLV 468 Query: 125 DANLNIKIADFGFSNLF----TPGQLLK-----------TWCGSPPYAAPELFEGKEYDG 169 N N+ +ADFG + L T + L+ T G+P + APE+ G+ YD Sbjct: 469 RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYD- 527 Query: 170 PKVDIWSLGVVLYVLV 185 KVD++S G+VL ++ Sbjct: 528 EKVDVFSFGIVLCEII 543 >gi|116051|sp|P24941|CDK2_HUMAN Cell division protein kinase 2 (p33 protein kinase) Length = 298 Score = 93.2 bits (230), Expect = 6e-19 Identities = 79/274 (28%), Positives = 122/274 (44%), Gaps = 37/274 (13%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T ++VA+K I E RE+ ++K L HP+I++L V+ TE +YLV E+ Sbjct: 26 TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ 85 Query: 76 G-EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 + F A + + Q++ + FCH ++HRDLK +NLL++ IK+AD Sbjct: 86 DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLAD 145 Query: 135 FGFSNLFTPGQLLKTWCGSPP---YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 FG + F G ++T+ Y APE+ G +Y VDIWSLG + +V F Sbjct: 146 FGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALF 203 Query: 192 DGS-----------TLQNLRARVLSGKFRIPFFMS----------TGLVPELDKRLKAGC 230 G TL V G +P + + +VP LD+ Sbjct: 204 PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDE------ 257 Query: 231 LSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 + L+ ML DPNKR+S + H + + Sbjct: 258 ----DGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287 >gi|1709347|sp|P51957|NEK4_HUMAN Serine/threonine-protein kinase Nek4 (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) Length = 841 Score = 93.2 bits (230), Expect = 6e-19 Identities = 71/255 (27%), Positives = 119/255 (46%), Gaps = 23/255 (9%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET-ERMIYLVTEY 72 ++ KQ V IK ++ + +E Q++ L HP+I+ + E + ++Y+V + Sbjct: 27 RDGKQYV-IKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGF 85 Query: 73 ASGGEIFDHLVAHGR--MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130 GG+++ L + E + F QI A+ + H ++I+HRDLK +N+ L I Sbjct: 86 CEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNII 145 Query: 131 KIADFGFSN-LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 K+ D G + L + T G+P Y +PELF K Y+ K D+W+LG +Y + Sbjct: 146 KVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYN-YKSDVWALGCCVYEMATLKH 204 Query: 190 PFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPN 249 F+ + +L R++ GK M PEL LIR ML P Sbjct: 205 AFNAKDMNSLVYRIIEGKLPA---MPRDYSPEL--------------AELIRTMLSKRPE 247 Query: 250 KRLSMEQICKHKWMK 264 +R S+ I + ++K Sbjct: 248 ERPSVRSILRQPYIK 262 >gi|23396789|sp|Q9NQU5|PAK6_HUMAN Serine/threonine-protein kinase PAK 6 (p21-activated kinase 6) (PAK-6) (PAK-5) Length = 681 Score = 92.4 bits (228), Expect = 1e-18 Identities = 62/246 (25%), Positives = 126/246 (51%), Gaps = 22/246 (8%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K++D + L +F EV IM+ H +++ +Y+ ++++ E+ GG + Sbjct: 433 VAVKMMDLRKQQRREL--LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALT 490 Query: 80 DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S 138 D +V+ R+ E++ + ++ A+ + H + ++HRD+K++++LL + +K++DFGF + Sbjct: 491 D-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCA 549 Query: 139 NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP-FDGSTLQ 197 + K+ G+P + APE+ Y +VDIWSLG+++ +V G P F S +Q Sbjct: 550 QISKDVPKRKSLVGTPYWMAPEVISRSLY-ATEVDIWSLGIMVIEMVDGEPPYFSDSPVQ 608 Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQI 257 ++ + P+L K + + MLV DP +R + +++ Sbjct: 609 AMKR------------LRDSPPPKLKNSHKVSPV----LRDFLERMLVRDPQERATAQEL 652 Query: 258 CKHKWM 263 H ++ Sbjct: 653 LDHPFL 658 >gi|46577700|sp|Q13188|STK3_HUMAN Serine/threonine-protein kinase 3 (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1) Length = 491 Score = 90.9 bits (224), Expect = 3e-18 Identities = 76/305 (24%), Positives = 140/305 (45%), Gaps = 25/305 (8%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + + +E+ Q+VAIK + E +L++I +E+ IM+ P++++ Y Sbjct: 39 GSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTD 94 Query: 66 IYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124 +++V EY G + D + + + E E K + + + H +HRD+KA N+LL Sbjct: 95 LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILL 154 Query: 125 DANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYV 183 + + K+ADFG + T + T G+P + APE+ + Y+ DIWSLG+ Sbjct: 155 NTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN-CVADIWSLGITSIE 213 Query: 184 LVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHM 243 + G P+ + + +RA + P F PEL + ++ Sbjct: 214 MAEGKPPY--ADIHPMRAIFMIPTNPPPTFRK----PELWS---------DDFTDFVKKC 258 Query: 244 LVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMG 303 LV +P +R + Q+ +H ++K LI E ++K +R + E L E+ Sbjct: 259 LVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRE---LEEEEEN 315 Query: 304 LDKEQ 308 D+++ Sbjct: 316 SDEDE 320 >gi|56749668|sp|Q9Y2H1|ST38L_HUMAN Serine/threonine-protein kinase 38-like (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) Length = 464 Score = 90.9 bits (224), Expect = 3e-18 Identities = 63/236 (26%), Positives = 112/236 (47%), Gaps = 38/236 (16%) Query: 14 QETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 ++T + A+KI+ K+ L++E + I E I+ +++++ + +R +YL+ E+ Sbjct: 110 KDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEF 169 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GG++ L+ + E+E + + V A+ H +HRD+K +NLLLDA ++K+ Sbjct: 170 LPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKL 229 Query: 133 ADFG--------------------------FSNLFTPG----------QLLKTWCGSPPY 156 +DFG F N+ + QL + G+P Y Sbjct: 230 SDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDY 289 Query: 157 AAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 212 APE+F Y+ D WSLGV++Y ++ G PF T Q +V++ K + F Sbjct: 290 IAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVF 344 >gi|13124559|sp|Q13043|STK4_HUMAN Serine/threonine-protein kinase 4 (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2) Length = 487 Score = 90.9 bits (224), Expect = 3e-18 Identities = 73/284 (25%), Positives = 129/284 (45%), Gaps = 22/284 (7%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + + +ET Q+VAIK + E +L++I +E+ IM+ PH+++ Y Sbjct: 42 GSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTD 97 Query: 66 IYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124 +++V EY G + D + + + E E + + + + H +HRD+KA N+LL Sbjct: 98 LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILL 157 Query: 125 DANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYV 183 + + K+ADFG + T + T G+P + APE+ + Y+ DIWSLG+ Sbjct: 158 NTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN-CVADIWSLGITAIE 216 Query: 184 LVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHM 243 + G P+ + + +RA + P F PEL ++ Sbjct: 217 MAEGKPPY--ADIHPMRAIFMIPTNPPPTFRK----PELWS---------DNFTDFVKQC 261 Query: 244 LVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQ 287 LV P +R + Q+ +H +++ LI E +K +RQ Sbjct: 262 LVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQ 305 >gi|2833269|sp|Q15835|RK_HUMAN Rhodopsin kinase (RK) (G protein-coupled receptor kinase 1) Length = 563 Score = 90.5 bits (223), Expect = 4e-18 Identities = 81/257 (31%), Positives = 126/257 (49%), Gaps = 22/257 (8%) Query: 13 LQETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71 ++ T +L A K ++K +L + + + E +I+ + I+ L ET+ + LV Sbjct: 209 MKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMT 268 Query: 72 YASGGEIFDHL--VAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDAN 127 +GG+I H+ V E R F QI+ + H R IV+RDLK EN+LLD + Sbjct: 269 IMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDND 328 Query: 128 LNIKIADFGFSNLFTPGQ-LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC 186 N++I+D G + GQ K + G+P + APEL +G+EYD VD ++LGV LY ++ Sbjct: 329 GNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDF-SVDYFALGVTLYEMIA 387 Query: 187 GALPF--DGSTLQN--LRARVLSGKFRIP--------FFMSTGLVPELDKRLKAGCLSIA 234 PF G ++N L+ R++S + P F L + +KRL Sbjct: 388 ARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLG---FRDE 444 Query: 235 ECEHLIRHMLVLDPNKR 251 C+ L H L D N R Sbjct: 445 TCDKLRAHPLFKDLNWR 461 >gi|12643880|sp|Q9UEW8|STK39_HUMAN STE20/SPS1-related proline-alanine rich protein kinase (Ste-20 related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 89.7 bits (221), Expect = 6e-18 Identities = 87/354 (24%), Positives = 151/354 (42%), Gaps = 41/354 (11%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 ++ VAIK I+ + + ++ ++ +E+Q M HP+++ Y + ++LV + SGG Sbjct: 88 QERVAIKRINLEKC-QTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGG 146 Query: 77 EIFD---HLVAHGR-----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL 128 + D ++V G + E K+++ + + H +HRDLKA N+LL + Sbjct: 147 SMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDG 206 Query: 129 NIKIADFGFSNLFTPG------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182 +++IADFG S G ++ KT+ G+P + APE+ E K D+WS G+ Sbjct: 207 SVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAI 266 Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRH 242 L GA P+ + L P + TG V + + K G L+ Sbjct: 267 ELATGAAPYHKYPPMKVLMLTLQND---PPTLETG-VEDKEMMKKYG----KSFRKLLSL 318 Query: 243 MLVLDPNKRLSMEQICKHK-WMKLGDADPNFDRLIAE----CQQLKEERQVDPLNEDVLL 297 L DP+KR + ++ K K + K + + ++L+ Q+ K+ R+V Sbjct: 319 CLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVP-------- 370 Query: 298 AMEDMGLDKEQTLQPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEV 351 G DG DE +E S E + + V +P V Sbjct: 371 -----GSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAV 419 >gi|1708824|sp|P53671|LIK2_HUMAN LIM domain kinase 2 (LIMK-2) Length = 638 Score = 89.0 bits (219), Expect = 1e-17 Identities = 55/176 (31%), Positives = 89/176 (50%), Gaps = 22/176 (12%) Query: 31 DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAE 90 DEE K EV++M+ L HP++++ V+ ++ + L+TEY GG + D L + Sbjct: 366 DEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPW 425 Query: 91 KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF--------- 141 ++ R K I + + + H I+HRDL + N L+ + + +ADFG S L Sbjct: 426 QQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPM 485 Query: 142 ----TPGQLLK--------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185 T + L+ T G+P + APE+ GK YD VDI+S G+VL ++ Sbjct: 486 EKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYD-ETVDIFSFGIVLCEII 540 >gi|57015279|sp|O14578|CTRO_HUMAN Citron Rho-interacting kinase (CRIK) (Rho-interacting, serine/threonine kinase 21) Length = 2027 Score = 88.6 bits (218), Expect = 1e-17 Identities = 72/272 (26%), Positives = 123/272 (45%), Gaps = 30/272 (11%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T + A+K++ K L + F E + I+ P I +L + + +YLV EY Sbjct: 119 TGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQP 178 Query: 75 GGEIFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GG++ L + ++ E + +++ AV+ H VHRD+K EN+L+D +IK+ Sbjct: 179 GGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLV 238 Query: 134 DFGFSNLFTPGQLL--KTWCGSPPYAAPELF-----EGKEYDGPKVDIWSLGVVLYVLVC 186 DFG + +++ K G+P Y APE+ +GK G D WS+GV+ Y ++ Sbjct: 239 DFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIY 298 Query: 187 GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246 G PF T AR + F+ P+ D ++ + L + + L+ Sbjct: 299 GRSPFAEGT----SARTFNNIMNFQRFLK---FPD-DPKVSSDFLDLIQ-------SLLC 343 Query: 247 DPNKRLSMEQICKH------KWMKLGDADPNF 272 +RL E +C H W + ++ P F Sbjct: 344 GQKERLKFEGLCCHPFFSKIDWNNIRNSPPPF 375 Score = 37.7 bits (86), Expect = 0.028 Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 13/120 (10%) Query: 1163 KLREQLGPVTQEFWDNLEK----ETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMEL 1218 KL EQL ++ + D+ +K E E +E+S + EE K +++ L + Q QE E Sbjct: 832 KLEEQLEKISHQ--DHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER-ES 888 Query: 1219 YRQKVEPLRAELQEGARQKLHELQEKLSPLGEEM------RDRARAHVDALRTHLAPYSD 1272 ++ RA L+ RQ EL+E + EE+ RD + DALR +D Sbjct: 889 QLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD 948 >gi|10719935|sp|Q14004|CD2L5_HUMAN Cell division cycle 2-like protein kinase 5 (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) Length = 418 Score = 88.6 bits (218), Expect = 1e-17 Identities = 77/296 (26%), Positives = 137/296 (46%), Gaps = 54/296 (18%) Query: 14 QETKQLVAIKIIDKTQLDEENLK---KIFREVQIMKMLCHPHIIRLYQVMETER------ 64 ++T ++VA+K K +LD E RE++I++ L H II + +++ + Sbjct: 111 KDTGEMVALK---KVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFK 167 Query: 65 ----MIYLVTEYASGGEIFDH----LVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVH 114 YLV EY DH L+ G E + +Q++ + +CH +N +H Sbjct: 168 KDKGAFYLVFEY------MDHDLMGLLESGLVHFYENHIKSFMRQLMEGLDYCHKKNFLH 221 Query: 115 RDLKAENLLLDANLNIKIADFGFSNLFT-------PGQLLKTWCGSPPYAAPELFEGKEY 167 RD+K N+LL+ IK+ADFG + L++ +++ W Y PEL G+E Sbjct: 222 RDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLW-----YRPPELLLGEER 276 Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGS---TLQNLRARVLSGK--------FRIPFFMST 216 P +D+WS G +L L F + L +R+ ++P+F + Sbjct: 277 YTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTM 336 Query: 217 GLVPELDKRLKAGCLSI-AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPN 271 + ++L+ + I A L +ML LDP+KR + EQ + ++++ D +P+ Sbjct: 337 KPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR--DVEPS 390 >gi|30316115|sp|Q9BUB5|MKNK1_HUMAN MAP kinase-interacting serine/threonine kinase 1 (MAP kinase signal-integrating kinase 1) (Mnk1) Length = 465 Score = 87.4 bits (215), Expect = 3e-17 Identities = 90/325 (27%), Positives = 132/325 (40%), Gaps = 91/325 (28%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTE 71 LQ K+ A+KII+K + ++FREV+ + + + +I+ L + E + YLV E Sbjct: 69 LQNGKEY-AVKIIEKQA--GHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFE 125 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN-------------------- 111 GG I H+ E+EA R + + A+ F H ++ Sbjct: 126 KLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAA 185 Query: 112 ---------------------IVHRDLKAENLLLDANLNI---KIADFGF------SNLF 141 I HRDLK EN+L ++ + KI DF +N Sbjct: 186 PTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSC 245 Query: 142 TPGQL--LKTWCGSPPYAAPELFE-----GKEYDGPKVDIWSLGVVLYVLVCGALPFDG- 193 TP L T CGS Y APE+ E YD + D+WSLGVVLY+++ G PF G Sbjct: 246 TPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD-KRCDLWSLGVVLYIMLSGYPPFVGH 304 Query: 194 -------------STLQN-LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239 QN L + GK+ P K +E + L Sbjct: 305 CGADCGWDRGEVCRVCQNKLFESIQEGKYEFPD--------------KDWAHISSEAKDL 350 Query: 240 IRHMLVLDPNKRLSMEQICKHKWMK 264 I +LV D +RLS Q+ +H W++ Sbjct: 351 ISKLLVRDAKQRLSAAQVLQHPWVQ 375 >gi|46396051|sp|Q9Y2A5|DUET_HUMAN Serine/threonine-protein kinase Duet (Serine/threonine kinase with Dbl- and pleckstrin homology domain) Length = 1289 Score = 87.0 bits (214), Expect = 4e-17 Identities = 54/199 (27%), Positives = 94/199 (47%), Gaps = 7/199 (3%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T++ VA+K + K +E E +++ L HP I L+ E+ L+ E Sbjct: 1009 TRKDVAVKFVSKKMKKKEQAA---HEAALLQHLQHPQYITLHDTYESPTSYILILELMDD 1065 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKI 132 G + D+L+ H + E++ + I+ A+ + H + H D+K ENLL+D + +K+ Sbjct: 1066 GRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKL 1125 Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 D + + + G+P +AAPE+ +G DIWS+GV+ YV++ G PF Sbjct: 1126 IDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPV-SLGTDIWSIGVLTYVMLSGVSPFL 1184 Query: 193 GSTLQNLRARVLSGKFRIP 211 + + V F P Sbjct: 1185 DESKEETCINVCRVDFSFP 1203 >gi|1170598|sp|P45984|MK09_HUMAN Mitogen-activated protein kinase 9 (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55) Length = 424 Score = 86.7 bits (213), Expect = 5e-17 Identities = 64/274 (23%), Positives = 121/274 (44%), Gaps = 34/274 (12%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA 73 VA+K + + ++ + K+ +RE+ ++K + H +II L V ++ +YLV E Sbjct: 52 VAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 111 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 V H + + Q++ + H I+HRDLK N+++ ++ +KI Sbjct: 112 DANLC---QVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 168 Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 DFG + ++ + + Y APE+ G Y VDIWS+G ++ LV G + F G Sbjct: 169 DFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGELVKGCVIFQG 227 Query: 194 S----------------------TLQNLRARVLSGKFRIPFFMSTGLVPE--LDKRLKAG 229 + LQ + + + P L P+ + Sbjct: 228 TDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287 Query: 230 CLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263 + ++ L+ MLV+DP+KR+S+++ +H ++ Sbjct: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321 >gi|14285497|sp|O14920|IKKB_HUMAN Inhibitor of nuclear factor kappa B kinase beta subunit (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) Length = 756 Score = 86.7 bits (213), Expect = 5e-17 Identities = 61/198 (30%), Positives = 97/198 (48%), Gaps = 14/198 (7%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G +I+ QET + +AIK + +L N ++ E+QIM+ L HP+++ V E + Sbjct: 27 GNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQN 85 Query: 66 I------YLVTEYASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRD 116 + L EY GG++ +L + E I +A+ + H I+HRD Sbjct: 86 LAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRD 145 Query: 117 LKAENLLL---DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173 LK EN++L + L KI D G++ G L ++ G+ Y APEL E ++Y VD Sbjct: 146 LKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT-VTVD 204 Query: 174 IWSLGVVLYVLVCGALPF 191 WS G + + + G PF Sbjct: 205 YWSFGTLAFECITGFRPF 222 >gi|8488988|sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Length = 1495 Score = 86.3 bits (212), Expect = 7e-17 Identities = 66/254 (25%), Positives = 112/254 (44%), Gaps = 22/254 (8%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 L KQ+ ++ Q EE ++ + E+++M L HP+IIR+ + L E+ Sbjct: 1251 LMAVKQVTYVRNTSSEQ--EEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEW 1308 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA-NLNIK 131 +GG + L +G E +Q++ + + H I+HRD+K NLL+D+ ++ Sbjct: 1309 MAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLR 1368 Query: 132 IADFGFSNLFT-----PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC 186 IADFG + G+ G+ + APE+ G++Y G D+WS+G + + C Sbjct: 1369 IADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQY-GRSCDVWSVGCAIIEMAC 1427 Query: 187 GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246 P++ N A + F+I S P + L G +A L L Sbjct: 1428 AKPPWNAEKHSNHLALI----FKI---ASATTAPSIPSHLSPGLRDVA------LRCLEL 1474 Query: 247 DPNKRLSMEQICKH 260 P R ++ KH Sbjct: 1475 QPQDRPPSRELLKH 1488 >gi|125480|sp|P07948|LYN_HUMAN Tyrosine-protein kinase Lyn Length = 512 Score = 86.3 bits (212), Expect = 7e-17 Identities = 56/183 (30%), Positives = 94/183 (51%), Gaps = 7/183 (3%) Query: 34 NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH--GRMAEK 91 +++ E +MK L H ++RLY V+ E IY++TEY + G + D L + G++ Sbjct: 283 SVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP 342 Query: 92 EARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWC 151 + QI + + +N +HRDL+A N+L+ +L KIADFG + + + Sbjct: 343 KLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREG 402 Query: 152 GSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGSTLQNLRARVLSGKF 208 P + APE + K D+WS G++LY +V G +P+ G T ++ LS + Sbjct: 403 AKFPIKWTAPEAINFGCFT-IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMT-ALSQGY 460 Query: 209 RIP 211 R+P Sbjct: 461 RMP 463 >gi|12643358|sp|O94804|STK10_HUMAN Serine/threonine-protein kinase 10 (Lymphocyte-oriented kinase) Length = 968 Score = 86.3 bits (212), Expect = 7e-17 Identities = 86/326 (26%), Positives = 146/326 (44%), Gaps = 37/326 (11%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 +ET L A K+I+ EE L+ E++I+ HP+I++L + ++++ E+ Sbjct: 56 KETGALAAAKVIETKS--EEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFC 113 Query: 74 SGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GG + ++ R + E + + +Q++ A+ F H + I+HRDLKA N+L+ +I++ Sbjct: 114 PGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRL 173 Query: 133 ADFGFS--NLFTPGQLLKTWCGSPPYAAPEL-----FEGKEYDGPKVDIWSLGVVLYVLV 185 ADFG S NL T Q ++ G+P + APE+ + YD K DIWSLG+ L + Sbjct: 174 ADFGVSAKNLKTL-QKRDSFIGTPYWMAPEVVMCETMKDTPYD-YKADIWSLGITLIEMA 231 Query: 186 CGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLV 245 P L +R + K P T L P E ++ L Sbjct: 232 QIEPPH--HELNPMRVLLKIAKSDPP----TLLTPSKWS---------VEFRDFLKIALD 276 Query: 246 LDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD 305 +P R S Q+ +H ++ ++ L+AE + E D +E + Sbjct: 277 KNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEG----------E 326 Query: 306 KEQTLQPDGTLNLDSDEGEEPSPEAL 331 +E + TL + E SP +L Sbjct: 327 EEDAVDAASTLENHTQNSSEVSPPSL 352 Score = 31.6 bits (70), Expect = 2.0 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 2/87 (2%) Query: 1161 FSKLREQLGPVTQEFWDNLEKETEGLRQE-MSKDLEEVKAKVQPYLDDFQKKWQEEMELY 1219 +++ +EQL + +E + +EK R+E M + +EE K Q DF K +E++EL Sbjct: 650 YTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELA 709 Query: 1220 RQKV-EPLRAELQEGARQKLHELQEKL 1245 +++ R E+ + R+ L + QE L Sbjct: 710 MKRLTTDNRREICDKERECLMKKQELL 736 >gi|20178302|sp|Q07002|PCTK3_HUMAN Serine/threonine-protein kinase PCTAIRE-3 (PCTAIRE-motif protein kinase 3) Length = 472 Score = 85.5 bits (210), Expect = 1e-16 Identities = 85/322 (26%), Positives = 146/322 (45%), Gaps = 43/322 (13%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 + LVA+K I + + +E REV ++K L H +I+ L+ ++ T+R + LV EY Sbjct: 165 ENLVALKEI-RLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSD 223 Query: 77 --EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 + DH M+ + Q++ + +CH R I+HRDLK +NLL++ +K+AD Sbjct: 224 LKQYLDH--CGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLAD 281 Query: 135 FGFSNL-FTPGQLLKTWCGSPPYAAPELFEGK-EYDGPKVDIWSLGVVLYVLVCGALPFD 192 FG + P + + Y P++ G EY P +D+W +G + Y + G F Sbjct: 282 FGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTP-IDMWGVGCIHYEMATGRPLFP 340 Query: 193 GSTLQ---NLRARVLS-------------GKFR---IPFFMSTGLV---PELDKRLKAGC 230 GST++ +L R+L +FR P ++ L+ P LD Sbjct: 341 GSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLD------- 393 Query: 231 LSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK-LGDADPNFDRLIAECQQLKE-ERQV 288 + HL+ +L+ + R+S E H + + LG+ + A LKE + Q Sbjct: 394 ---TDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLED-TASIFSLKEIQLQK 449 Query: 289 DPLNEDVLLAMEDMGLDKEQTL 310 DP + G ++ Q++ Sbjct: 450 DPGYRGLAFQQPGRGKNRRQSI 471 >gi|34222826|sp|Q86UE8|TLK2_HUMAN Serine/threonine-protein kinase tousled-like 2 (Tousled-like kinase 2) (PKU-alpha) Length = 772 Score = 85.5 bits (210), Expect = 1e-16 Identities = 83/256 (32%), Positives = 118/256 (46%), Gaps = 25/256 (9%) Query: 17 KQLVAIKI--IDKTQLDE--ENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIYL-VT 70 ++ VA+KI ++K DE EN K RE +I K L HP I++LY + + V Sbjct: 485 QRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVL 544 Query: 71 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH--CRNIVHRDLKAENLLL---D 125 EY G ++ +L H M+EKEAR QIV A+ + + I+H DLK N+LL Sbjct: 545 EYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGT 604 Query: 126 ANLNIKIADFGFSNLFTPG--------QLLKTWCGSPPYAAPELF-EGKEYD--GPKVDI 174 A IKI DFG S + +L G+ Y PE F GKE KVD+ Sbjct: 605 ACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDV 664 Query: 175 WSLGVVLYVLVCGALPFDGSTLQN--LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLS 232 WS+GV+ Y + G PF + Q L+ + + F + PE K CL+ Sbjct: 665 WSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA-KAFIRRCLA 723 Query: 233 IAECEHLIRHMLVLDP 248 + + + L DP Sbjct: 724 YRKEDRIDVQQLACDP 739 >gi|114006|sp|P06727|APOA4_HUMAN Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV) Length = 396 Score = 85.5 bits (210), Expect = 1e-16 Identities = 53/229 (23%), Positives = 106/229 (46%), Gaps = 11/229 (4%) Query: 1113 DRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVT 1172 D+V + Y L ++ ++ V + S L +QLN D V + L+++L P Sbjct: 25 DQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFA 84 Query: 1173 QEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQE 1232 E + L K++E L++E+ K+LEE++A++ P+ ++ +K + + +Q++EP +L+ Sbjct: 85 TELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRT 144 Query: 1233 GARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDXXXXXXXXXXXXXXXNGGAR 1292 + +L+ +L+P + M R + D+L+ L P++D Sbjct: 145 QVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKI-----------DQN 193 Query: 1293 LAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYT 1341 + E + T + K +E+LR+ L P + + LE T Sbjct: 194 VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLT 242 Score = 56.6 bits (135), Expect = 6e-08 Identities = 44/199 (22%), Positives = 84/199 (42%), Gaps = 26/199 (13%) Query: 1157 VTSTFSKLREQLGPVTQEF-----------WDNLEKETEGLRQEMSKDLEEVKAKVQPYL 1205 V + +LR QL P Q +L + L+ ++ +++EE+K ++ PY Sbjct: 146 VNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYA 205 Query: 1206 DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRT 1265 D+F+ K + +E R+ + P + QE +L L ++ EE++ R A + LR Sbjct: 206 DEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQ 265 Query: 1266 HLAPYSDXXXXXXXXXXXXXXXNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPV 1325 LAP ++ L + L+ L +E+ R+ + P Sbjct: 266 RLAPLAEDVR---------------GNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPY 310 Query: 1326 LESFKVSFLSALEEYTKKL 1344 E+F + + +E+ +KL Sbjct: 311 GENFNKALVQQMEQLRQKL 329 Score = 51.2 bits (121), Expect = 2e-06 Identities = 33/148 (22%), Positives = 75/148 (50%), Gaps = 9/148 (6%) Query: 1115 VKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQE 1174 V++L +D+ Q EG + N + L ++++ +LR++L P+ ++ Sbjct: 216 VEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKA--RISASAEELRQRLAPLAED 273 Query: 1175 FWDNLEKETEGLRQEMSK-------DLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLR 1227 NL+ TEGL++ +++ +EE + +V+PY ++F K ++ME RQK+ P Sbjct: 274 VRGNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHA 333 Query: 1228 AELQEGARQKLHELQEKLSPLGEEMRDR 1255 +++ +L++K++ +++ Sbjct: 334 GDVEGHLSFLEKDLRDKVNSFFSTFKEK 361 Score = 49.7 bits (117), Expect = 7e-06 Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%) Query: 1157 VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEM 1216 + T +LR L P Q+ + L + EGL +M K+ EE+KA++ ++ +++ Sbjct: 212 IDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLA 271 Query: 1217 ELYR-------QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAP 1269 E R + ++ AEL Q++ E + ++ P GE ++ LR L P Sbjct: 272 EDVRGNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGP 331 Query: 1270 YS 1271 ++ Sbjct: 332 HA 333 >gi|56749457|sp|Q15208|STK38_HUMAN Serine/threonine-protein kinase 38 (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1) Length = 465 Score = 85.1 bits (209), Expect = 2e-16 Identities = 61/237 (25%), Positives = 111/237 (46%), Gaps = 40/237 (16%) Query: 14 QETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72 ++T + A+KI+ K L++E + I E I+ +++++ + + +YL+ E+ Sbjct: 109 KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEF 168 Query: 73 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 GG++ L+ + E+E + + V A+ H +HRD+K +NLLLD+ ++K+ Sbjct: 169 LPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKL 228 Query: 133 ADFG--------------------------FSNLFTPGQLLKTW-----------CGSPP 155 +DFG F N+ + + +TW G+P Sbjct: 229 SDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKA-ETWKRNRRQLAFSTVGTPD 287 Query: 156 YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 212 Y APE+F Y+ D WSLGV++Y ++ G PF T Q +V++ K + F Sbjct: 288 YIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTF 343 >gi|462203|sp|P34947|GRK5_HUMAN G protein-coupled receptor kinase 5 (G protein-coupled receptor kinase GRK5) Length = 590 Score = 85.1 bits (209), Expect = 2e-16 Identities = 54/184 (29%), Positives = 95/184 (51%), Gaps = 4/184 (2%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71 ++ T ++ A K ++K ++ + + + E QI++ + ++ L ET+ + LV Sbjct: 205 VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLT 264 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 +GG++ H+ G +E R F +I+ + H N V+RDLK EN+LLD + Sbjct: 265 IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH 324 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 I+I+D G + G L++ G+ Y APE+ + Y G D W LG ++Y ++ G Sbjct: 325 IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQS 383 Query: 190 PFDG 193 PF G Sbjct: 384 PFRG 387 >gi|1706450|sp|Q09013|DMPK_HUMAN Myotonin-protein kinase (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 639 Score = 85.1 bits (209), Expect = 2e-16 Identities = 63/219 (28%), Positives = 107/219 (48%), Gaps = 10/219 (4%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTE 71 +++T Q+ A+KI++K + + FRE + ++ I +L+ + E +YLV E Sbjct: 100 MKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME 159 Query: 72 YASGGEIFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130 Y GG++ L G R+ + AR +IV A+ H VHRD+K +N+LLD +I Sbjct: 160 YYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHI 219 Query: 131 KIADFGFSNLFTPGQLLKTW--CGSPPYAAPELFE------GKEYDGPKVDIWSLGVVLY 182 ++ADFG +++ G+P Y +PE+ + G GP+ D W+LGV Y Sbjct: 220 RLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAY 279 Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPE 221 + G PF + +++ K + + VPE Sbjct: 280 EMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPE 318 >gi|14285498|sp|O15111|IKKA_HUMAN Inhibitor of nuclear factor kappa-B kinase alpha subunit (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NFkappaB inhibitor kinase alpha) (NFKBIKA) Length = 745 Score = 84.3 bits (207), Expect = 3e-16 Identities = 57/183 (31%), Positives = 90/183 (49%), Gaps = 13/183 (7%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY-----LVTEYAS 74 +AIK + +L +N ++ E+QIMK L H ++++ V E ++ L EY S Sbjct: 41 IAIKSC-RLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCS 99 Query: 75 GGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD---ANL 128 GG++ L + E + I + + + H I+HRDLK EN++L + Sbjct: 100 GGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKI 159 Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188 KI D G++ G L ++ G+ Y APELFE K Y VD WS G +++ + G Sbjct: 160 IHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTA-TVDYWSFGTMVFECIAGY 218 Query: 189 LPF 191 PF Sbjct: 219 RPF 221 >gi|59803097|sp|Q00537|PCTK2_HUMAN Serine/threonine-protein kinase PCTAIRE-2 (PCTAIRE-motif protein kinase 2) Length = 523 Score = 84.3 bits (207), Expect = 3e-16 Identities = 70/273 (25%), Positives = 126/273 (46%), Gaps = 36/273 (13%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T+ LVA+K I + + +E REV ++K L H +I+ L+ ++ T++ + LV EY Sbjct: 214 TENLVALKEI-RLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDK 272 Query: 76 GEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 ++ ++ G + + F QI+ + +CH R ++HRDLK +NLL++ +K+AD Sbjct: 273 -DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLAD 331 Query: 135 FGFSNL-FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 FG + P + + Y P++ G ++D+W +G + + + G F G Sbjct: 332 FGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG 391 Query: 194 STLQ---NLRARVLS----------------GKFRIPFFMSTGLV---PELDKRLKAGCL 231 ST++ +L R+L + P + L+ P LD Sbjct: 392 STVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLD-------- 443 Query: 232 SIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 +E LI L + KR+S E+ KH + + Sbjct: 444 --SEGIELITKFLQYESKKRVSAEEAMKHVYFR 474 >gi|20141386|sp|P43250|GRK6_HUMAN G protein-coupled receptor kinase 6 (G protein-coupled receptor kinase GRK6) Length = 576 Score = 84.0 bits (206), Expect = 3e-16 Identities = 55/182 (30%), Positives = 96/182 (52%), Gaps = 4/182 (2%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71 ++ T ++ A K ++K ++ + + + E QI++ + ++ L ET+ + LV Sbjct: 205 VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT 264 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 +GG++ H+ G+ EAR F +I + H IV+RDLK EN+LLD + + Sbjct: 265 LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH 324 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 I+I+D G + GQ +K G+ Y APE+ + + Y D W+LG +LY ++ G Sbjct: 325 IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWWALGCLLYEMIAGQS 383 Query: 190 PF 191 PF Sbjct: 384 PF 385 >gi|125351|sp|P16591|FER_HUMAN Proto-oncogene tyrosine-protein kinase FER (p94-FER) (c-FER) Length = 822 Score = 84.0 bits (206), Expect = 3e-16 Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 18/200 (9%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 K VA+K K L +E K +E +I+K HP+I++L V + +Y++ E SGG Sbjct: 585 KTSVAVKTC-KEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGG 643 Query: 77 EIFDHLVAHGRMAEKEARRKFKQIV-------TAVYFCHCRNIVHRDLKAENLLLDANLN 129 + L K+ K KQ+V + + +N +HRDL A N L+ N Sbjct: 644 DFLTFL------RRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNV 697 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVC 186 +KI+DFG S G + P + APE Y + D+WS G++L+ Sbjct: 698 LKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSS-ESDVWSFGILLWETFSL 756 Query: 187 GALPFDGSTLQNLRARVLSG 206 G P+ G T Q R +V G Sbjct: 757 GVCPYPGMTNQQAREQVERG 776 >gi|1169745|sp|P42685|FRK_HUMAN Tyrosine-protein kinase FRK (Nuclear tyrosine protein kinase RAK) Length = 505 Score = 84.0 bits (206), Expect = 3e-16 Identities = 59/206 (28%), Positives = 100/206 (48%), Gaps = 25/206 (12%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K + +D + RE QIMK L HP +I+LY V E IY++TE G + Sbjct: 259 VAVKTLKPGSMDPNDF---LREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQ 315 Query: 80 DHLV--AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 ++L ++ + Q+ + + + RN +HRDL A N+L+ + K+ADFG Sbjct: 316 EYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGL 375 Query: 138 SNLFTPG-----------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLV 185 + +F +L W APE ++ K D+WS G++LY ++ Sbjct: 376 ARVFKVDNEDIYESRHEIKLPVKW------TAPEAIRSNKF-SIKSDVWSFGILLYEIIT 428 Query: 186 CGALPFDGSTLQNLRARVLSGKFRIP 211 G +P+ G T + ++L+ +R+P Sbjct: 429 YGKMPYSGMTGAQV-IQMLAQNYRLP 453 >gi|266425|sp|Q00536|PCTK1_HUMAN Serine/threonine-protein kinase PCTAIRE-1 (PCTAIRE-motif protein kinase 1) Length = 496 Score = 83.2 bits (204), Expect = 6e-16 Identities = 53/184 (28%), Positives = 97/184 (52%), Gaps = 4/184 (2%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T LVA+K I + + +E REV ++K L H +I+ L+ ++ TE+ + LV EY Sbjct: 187 TDNLVALKEI-RLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDK 245 Query: 76 GEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 ++ +L G + + F Q++ + +CH + ++HRDLK +NLL++ +K+AD Sbjct: 246 -DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLAD 304 Query: 135 FGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 FG + + P + + Y P++ G ++D+W +G + Y + G F G Sbjct: 305 FGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG 364 Query: 194 STLQ 197 ST++ Sbjct: 365 STVE 368 >gi|125474|sp|P06239|LCK_HUMAN Proto-oncogene tyrosine-protein kinase LCK (P56-LCK) (LSK) (T cell-specific protein-tyrosine kinase) Length = 509 Score = 83.2 bits (204), Expect = 6e-16 Identities = 59/189 (31%), Positives = 92/189 (48%), Gaps = 14/189 (7%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K + + + + E +MK L H ++RLY V+ T+ IY++TEY G + Sbjct: 270 VAVKSLKQGSMSPD---AFLAEANLMKQLQHQRLVRLYAVV-TQEPIYIITEYMENGSLV 325 Query: 80 DHLVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 D L ++ + QI + F RN +HRDL+A N+L+ L+ KIADFG Sbjct: 326 DFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGL 385 Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS 194 + L + P + APE + K D+WS G++L +V G +P+ G Sbjct: 386 ARLIEDNEYTAREGAKFPIKWTAPEAINYGTFT-IKSDVWSFGILLTEIVTHGRIPYPGM 444 Query: 195 T----LQNL 199 T +QNL Sbjct: 445 TNPEVIQNL 453 >gi|34223086|sp|Q9UKI8|TLK1_HUMAN Serine/threonine-protein kinase tousled-like 1 (Tousled-like kinase 1) (PKU-beta) Length = 766 Score = 82.4 bits (202), Expect = 1e-15 Identities = 81/259 (31%), Positives = 116/259 (44%), Gaps = 22/259 (8%) Query: 11 DFLQETKQLVAIKIIDKTQLDE--ENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIY 67 D ++ V I ++K+ DE EN K RE +I K L HP I++LY + + Sbjct: 475 DLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTF 534 Query: 68 L-VTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH--CRNIVHRDLKAENLLL 124 V EY G ++ +L H M+EKEAR QIV A+ + + I+H DLK N+LL Sbjct: 535 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILL 594 Query: 125 ---DANLNIKIADFGFSNLFTPG-------QLLKTWCGSPPYAAPELF-EGKEYD--GPK 171 A IKI DFG S + L G+ Y PE F GKE K Sbjct: 595 VDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNK 654 Query: 172 VDIWSLGVVLYVLVCGALPFDGSTLQN--LRARVLSGKFRIPFFMSTGLVPELDKRLKAG 229 VD+WS+GV+ + + G PF + Q L+ + + F + +V K Sbjct: 655 VDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKP-VVSSEAKAFIRR 713 Query: 230 CLSIAECEHLIRHMLVLDP 248 CL+ + + H L DP Sbjct: 714 CLAYRKEDRFDVHQLANDP 732 >gi|464971|sp|P33981|TTK_HUMAN Dual specificity protein kinase TTK (Phosphotyrosine picked threonine kinase) (PYT) Length = 841 Score = 82.4 bits (202), Expect = 1e-15 Identities = 69/270 (25%), Positives = 121/270 (44%), Gaps = 36/270 (13%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH--PHIIRLYQVMETERMIYLVT 70 L E KQ+ AIK ++ + D + L E+ + L IIRLY T++ IY+V Sbjct: 527 LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVM 586 Query: 71 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130 E ++ L + E + +K ++ AV+ H IVH DLK N L+ + + Sbjct: 587 E-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-L 644 Query: 131 KIADFGFSNLFTPGQ---LLKTWCGSPPYAAPELFE----------GKEYDGPKVDIWSL 177 K+ DFG +N P + + G+ Y PE + K PK D+WSL Sbjct: 645 KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL 704 Query: 178 GVVLYVLVCGALPFDG--STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAE 235 G +LY + G PF + + L A ++ I F P++ ++ + Sbjct: 705 GCILYYMTYGKTPFQQIINQISKLHA-IIDPNHEIEF-------PDIPEK---------D 747 Query: 236 CEHLIRHMLVLDPNKRLSMEQICKHKWMKL 265 + +++ L DP +R+S+ ++ H ++++ Sbjct: 748 LQDVLKCCLKRDPKQRISIPELLAHPYVQI 777 >gi|19857975|sp|P29322|EPHA8_HUMAN Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase) (HEK3) Length = 1005 Score = 82.4 bits (202), Expect = 1e-15 Identities = 63/198 (31%), Positives = 95/198 (47%), Gaps = 9/198 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + K E + E IM HP+IIRL V+ R+ +VTEY G + Sbjct: 664 VAIKAL-KAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLD 722 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L H G+ + + + + + VHRDL A N+L+D+NL K++DFG S Sbjct: 723 TFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLS 782 Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193 + P T G P + APE + + D+WS GVV++ VL G P+ Sbjct: 783 RVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSAS-DVWSFGVVMWEVLAYGERPYWN 841 Query: 194 STLQNLRARVLSGKFRIP 211 T +++ + V G +R+P Sbjct: 842 MTNRDVISSVEEG-YRLP 858 >gi|8928302|sp|Q13882|PTK6_HUMAN Tyrosine-protein kinase 6 (Breast tumor kinase) (Tyrosine-protein kinase brk) Length = 451 Score = 82.0 bits (201), Expect = 1e-15 Identities = 62/212 (29%), Positives = 101/212 (47%), Gaps = 10/212 (4%) Query: 6 GYIIQDF--LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE 63 GY + F L + + VAIK+I + L + + + E+Q MK L H HI+ LY V+ Sbjct: 200 GYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQ--SEIQAMKKLRHKHILALYAVVSVG 257 Query: 64 RMIYLVTEYASGGEIFDHLVAHGR--MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121 +Y++TE + G + + L + E Q+ + + +N +HRDL A N Sbjct: 258 DPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARN 317 Query: 122 LLLDANLNIKIADFGFSNLFTPGQLLKTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVV 180 +L+ N K+ DFG + L L P + APE Y K D+WS G++ Sbjct: 318 ILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHY-STKSDVWSFGIL 376 Query: 181 LYVLVC-GALPFDGSTLQNLRARVLSGKFRIP 211 L+ + G +P+ G + RV +G +R+P Sbjct: 377 LHEMFSRGQVPYPGMSNHEAFLRVDAG-YRMP 407 >gi|41688789|sp|Q96J92|WNK4_HUMAN Serine/threonine-protein kinase WNK4 (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4) Length = 1243 Score = 82.0 bits (201), Expect = 1e-15 Identities = 65/243 (26%), Positives = 119/243 (48%), Gaps = 25/243 (10%) Query: 29 QLDEENLKKIFREVQIMKMLCHPHIIRLYQ----VMETERMIYLVTEYASGGEIFDHLVA 84 +L ++ EV+++K L HP+I+R Y V+ + I LVTE + G + +L Sbjct: 209 KLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRR 268 Query: 85 HGRMAEKEARRKFKQIVTAVYFCHCR--NIVHRDLKAENLLLDANL-NIKIADFGFSNLF 141 M + +R +QI+ ++F H R I+HRDLK +N+ + ++KI D G + L Sbjct: 269 FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL- 327 Query: 142 TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRA 201 K+ G+P + APE++E K YD VD+++ G+ + + P+ S QN Sbjct: 328 KRASFAKSVIGTPEFMAPEMYEEK-YD-EAVDVYAFGMCMLEMATSEYPY--SECQNAA- 382 Query: 202 RVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHK 261 +I +++G P ++K I E + +I + D N+R +++ + H Sbjct: 383 -------QIYRKVTSGRKPNSFHKVK-----IPEVKEIIEGCIRTDKNERFTIQDLLAHA 430 Query: 262 WMK 264 + + Sbjct: 431 FFR 433 >gi|125135|sp|P00519|ABL1_HUMAN Proto-oncogene tyrosine-protein kinase ABL1 (p150) (c-ABL) Length = 1130 Score = 81.6 bits (200), Expect = 2e-15 Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 11/200 (5%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + + ++ VA+K + + ++ E K E +MK + HP++++L V E Sbjct: 254 GEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK---EAAVMKEIKHPNLVQLLGVCTREPP 310 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK--QIVTAVYFCHCRNIVHRDLKAENLL 123 Y++TE+ + G + D+L R + QI +A+ + +N +HRDL A N L Sbjct: 311 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 370 Query: 124 LDANLNIKIADFGFSNLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVV 180 + N +K+ADFG S L T G G+ + APE ++ K D+W+ GV+ Sbjct: 371 VGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKF-SIKSDVWAFGVL 428 Query: 181 LY-VLVCGALPFDGSTLQNL 199 L+ + G P+ G L + Sbjct: 429 LWEIATYGMSPYPGIDLSQV 448 >gi|1351326|sp|P42681|TXK_HUMAN Tyrosine-protein kinase TXK Length = 527 Score = 81.6 bits (200), Expect = 2e-15 Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 11/196 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK I++ + EE+ E ++M L H +++LY V + +Y+VTE+ G + Sbjct: 296 VAIKAINEGSMSEEDF---IEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLL 352 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 ++L + G++ ++ + I + + +HRDL A N L+ + +KI+DFG + Sbjct: 353 NYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMT 412 Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG-S 194 + + ++ P ++ PE+F +Y K D+WS GV+++ V G +PF+ S Sbjct: 413 RYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSS-KSDVWSFGVLMWEVFTEGKMPFENKS 471 Query: 195 TLQNLRARVLSGKFRI 210 LQ + A +S FR+ Sbjct: 472 NLQVVEA--ISEGFRL 485 >gi|2507195|sp|P45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46) Length = 427 Score = 81.3 bits (199), Expect = 2e-15 Identities = 69/279 (24%), Positives = 128/279 (45%), Gaps = 40/279 (14%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA 73 VAIK + + ++ + K+ +RE+ +MK + H +II L V ++ +Y+V E Sbjct: 52 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELM 111 Query: 74 SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 ++ + H RM+ Q++ + H I+HRDLK N+++ ++ +K Sbjct: 112 DANLCQVIQMELDHERMSYL-----LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 166 Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 I DFG + ++ + + Y APE+ G Y VD+WS+G ++ +VC + F Sbjct: 167 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK-ENVDLWSVGCIMGEMVCHKILF 225 Query: 192 DGSTLQNLRARVLSG-KFRIPFFMSTGLVPELD--------------KRLKAGCLSIAEC 236 G + +V+ P FM L P + ++L L A+ Sbjct: 226 PGRDYIDQWNKVIEQLGTPCPEFMKK-LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADS 284 Query: 237 EH----------LIRHMLVLDPNKRLSMEQICKHKWMKL 265 EH L+ MLV+D +KR+S+++ +H ++ + Sbjct: 285 EHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINV 323 >gi|29427817|sp|Q8IVH8|M4K3_HUMAN Mitogen-activated protein kinase kinase kinase kinase 3 (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase related protein kinase) (GLK) Length = 894 Score = 81.3 bits (199), Expect = 2e-15 Identities = 67/252 (26%), Positives = 119/252 (47%), Gaps = 20/252 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T +L AIK+I E+ + +E+ +MK HP+I+ + +++ E+ G Sbjct: 38 TGELAAIKVIKLEP--GEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGG 95 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 G + D G ++E + ++ + +Y+ H + +HRD+K N+LL N ++K+ADF Sbjct: 96 GSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADF 155 Query: 136 GFSNLFTPG-QLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALP-F 191 G S T K++ G+P + APE+ E K D+W++G+ L P F Sbjct: 156 GVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMF 215 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 D L +RA L K S P+L ++K H ++ L +P KR Sbjct: 216 D---LHPMRALFLMTK-------SNFQPPKLKDKMKWS----NSFHHFVKMALTKNPKKR 261 Query: 252 LSMEQICKHKWM 263 + E++ +H ++ Sbjct: 262 PTAEKLLQHPFV 273 >gi|1730068|sp|P10398|ARAF_HUMAN A-Raf proto-oncogene serine/threonine-protein kinase (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 80.9 bits (198), Expect = 3e-15 Identities = 51/178 (28%), Positives = 95/178 (53%), Gaps = 7/178 (3%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K++ +Q E + E+Q+++ H +I+ L+ T ++T++ G ++ Sbjct: 333 VAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLY 391 Query: 80 DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 HL VA R + +Q + + H +NI+HRDLK+ N+ L L +KI DFG + Sbjct: 392 HHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLA 451 Query: 139 NL---FTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPF 191 + ++ Q L+ GS + A E+ ++ + + D+++ GVVLY L+ G+LP+ Sbjct: 452 TVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPY 509 >gi|2507196|sp|P53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) Length = 464 Score = 80.9 bits (198), Expect = 3e-15 Identities = 68/281 (24%), Positives = 122/281 (43%), Gaps = 44/281 (15%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA 73 VAIK + + ++ + K+ +RE+ +MK + H +II L V ++ +YLV E Sbjct: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 Query: 74 SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 ++ + H RM+ Q++ + H I+HRDLK N+++ ++ +K Sbjct: 150 DANLCQVIQMELDHERMSYL-----LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 I DFG + ++ + + Y APE+ G Y VDIWS+G ++ +V + F Sbjct: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILF 263 Query: 192 DG--------------------------STLQN-LRARVLSGKFRIPFFMSTGLVPELDK 224 G T++N + R P L P + Sbjct: 264 PGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSE 323 Query: 225 RLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 265 K L ++ L+ MLV+DP KR+S++ +H ++ + Sbjct: 324 HNK---LKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 >gi|1168268|sp|P42684|ABL2_HUMAN Tyrosine-protein kinase ABL2 (Tyrosine kinase ARG) Length = 1182 Score = 80.5 bits (197), Expect = 4e-15 Identities = 57/186 (30%), Positives = 90/186 (48%), Gaps = 11/186 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K + + ++ E K E +MK + HP++++L V E Y+VTEY G + Sbjct: 314 VAVKTLKEDTMEVEEFLK---EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLL 370 Query: 80 DHLVAHGRMAEKEARRKFK--QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 D+L R + QI +A+ + +N +HRDL A N L+ N +K+ADFG Sbjct: 371 DYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGL 430 Query: 138 SNLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193 S L T G G+ + APE + K D+W+ GV+L+ + G P+ G Sbjct: 431 SRLMT-GDTYTAHAGAKFPIKWTAPESLAYNTF-SIKSDVWAFGVLLWEIATYGMSPYPG 488 Query: 194 STLQNL 199 L + Sbjct: 489 IDLSQV 494 >gi|41688795|sp|Q9H4A3|WNK1_HUMAN Serine/threonine-protein kinase WNK1 (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein) Length = 2382 Score = 80.5 bits (197), Expect = 4e-15 Identities = 68/227 (29%), Positives = 111/227 (48%), Gaps = 18/227 (7%) Query: 15 ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET----ERMIYLVT 70 ET VA + +L + ++ E +++K L HP+I+R Y E+ ++ I LVT Sbjct: 242 ETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVT 301 Query: 71 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL 128 E + G + +L M K R +QI+ + F H R I+HRDLK +N+ + Sbjct: 302 ELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPT 361 Query: 129 -NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187 ++KI D G + L K+ G+P + APE++E K YD VD+++ G+ + + Sbjct: 362 GSVKIGDLGLATL-KRASFAKSVIGTPEFMAPEMYEEK-YD-ESVDVYAFGMCMLEMATS 418 Query: 188 ALPFDGSTLQN---LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCL 231 P+ S QN + RV SG P +PE+ K + GC+ Sbjct: 419 EYPY--SECQNAAQIYRRVTSGV--KPASFDKVAIPEV-KEIIEGCI 460 >gi|27805732|sp|Q9H3Y6|SRMS_HUMAN Tyrosine-protein kinase Srms Length = 488 Score = 80.5 bits (197), Expect = 4e-15 Identities = 61/197 (30%), Positives = 94/197 (47%), Gaps = 10/197 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK+I + +L K E+Q +K L H +IRL+ V +Y+VTE G + Sbjct: 255 VAIKVIKSANMKLTDLAK---EIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQ 311 Query: 80 DHL-VAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 L GR F Q+ + + + +VHRDL A N+L+D L K+ADFG Sbjct: 312 AFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGL 371 Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS 194 + L + P + APE + + K D+WS GV+L+ V G P++G Sbjct: 372 ARLLKDDIYSPSSSSKIPVKWTAPEAANYRVF-SQKSDVWSFGVLLHEVFTYGQCPYEGM 430 Query: 195 TLQNLRARVLSGKFRIP 211 T +++ G +R+P Sbjct: 431 TNHETLQQIMRG-YRLP 446 >gi|125651|sp|P04049|RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 80.1 bits (196), Expect = 5e-15 Identities = 65/257 (25%), Positives = 124/257 (48%), Gaps = 23/257 (8%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+KI+ E + EV +++ H +I+ L+ T+ + +VT++ G ++ Sbjct: 372 VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLY 430 Query: 80 DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 HL V + + +Q + + H +NI+HRD+K+ N+ L L +KI DFG + Sbjct: 431 KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA 490 Query: 139 NL---FTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFDG 193 + ++ Q ++ GS + APE+ ++ + + D++S G+VLY L+ G LP+ Sbjct: 491 TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSH 550 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLV-PELDKRL----KAGCLSIAECEHLIRHMLVLDP 248 ++ + +I F + G P+L K KA +A+C ++ L P Sbjct: 551 ----------INNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP 600 Query: 249 NKRLSMEQICKHKWMKL 265 + LS ++ +H K+ Sbjct: 601 -QILSSIELLQHSLPKI 616 >gi|50403720|sp|P15056|BRAF1_HUMAN B-Raf proto-oncogene serine/threonine-protein kinase (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 80.1 bits (196), Expect = 5e-15 Identities = 63/252 (25%), Positives = 123/252 (48%), Gaps = 24/252 (9%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VA+K+++ T + L+ EV +++ H +I+ L+ T+ + +VT++ G ++ Sbjct: 480 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLY 538 Query: 80 DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 HL + + + +Q + + H ++I+HRDLK+ N+ L +L +KI DFG + Sbjct: 539 HHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA 598 Query: 139 NL---FTPGQLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 + ++ + GS + APE+ + K + D+++ G+VLY L+ G LP+ Sbjct: 599 TVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN 658 Query: 194 STLQNLRARVLSGKFRIPFFMSTG-LVPELDKRLKAGCLS-----IAECEHLIRHMLVLD 247 ++ + +I F + G L P+L K +++ C +AEC R L Sbjct: 659 ----------INNRDQIIFMVGRGYLSPDLSK-VRSNCPKAMKRLMAECLKKKRDERPLF 707 Query: 248 PNKRLSMEQICK 259 P S+E + + Sbjct: 708 PQILASIELLAR 719 >gi|12643557|sp|O43318|M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 80.1 bits (196), Expect = 5e-15 Identities = 80/251 (31%), Positives = 119/251 (47%), Gaps = 39/251 (15%) Query: 20 VAIKIIDKTQLDEENLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78 VAIK Q++ E+ +K F E++ + + HP+I++LY + LV EYA GG + Sbjct: 60 VAIK-----QIESESERKAFIVELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSL 112 Query: 79 FDHLVAHGR-----MAEKEARRKFKQIVTAVYFCHC---RNIVHRDLKAENLLLDANLNI 130 ++ V HG A Q V + H + ++HRDLK NLLL A + Sbjct: 113 YN--VLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTV 170 Query: 131 -KIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188 KI DFG + ++ T K GS + APE+FEG Y K D++S G++L+ ++ Sbjct: 171 LKICDFGTACDIQTHMTNNK---GSAAWMAPEVFEGSNY-SEKCDVFSWGIILWEVITRR 226 Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248 PFD + FRI + + G P L K L E L+ DP Sbjct: 227 KPFD---------EIGGPAFRIMWAVHNGTRPPLIKNLP------KPIESLMTRCWSKDP 271 Query: 249 NKRLSMEQICK 259 ++R SME+I K Sbjct: 272 SQRPSMEEIVK 282 >gi|41688792|sp|Q9BYP7|WNK3_HUMAN Serine/threonine-protein kinase WNK3 (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3) Length = 1743 Score = 80.1 bits (196), Expect = 5e-15 Identities = 67/228 (29%), Positives = 115/228 (50%), Gaps = 22/228 (9%) Query: 28 TQLDEENLKKIFREVQIMKMLCHPHIIRLY----QVMETERMIYLVTEYASGGEIFDHLV 83 T+ +++ K+ E +++K L HP+I+R Y +++ ++ I LVTE + G + +L Sbjct: 184 TKAEQQRFKE---EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 240 Query: 84 AHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL-NIKIADFGFSNL 140 M K R +QI+ + F H R I+HRDLK +N+ + ++KI D G + L Sbjct: 241 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 300 Query: 141 FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN-- 198 K+ G+P + APE++E E+ VD+++ G+ + + P+ S QN Sbjct: 301 MRT-SFAKSVIGTPEFMAPEMYE--EHYDESVDVYAFGMCMLEMATSEYPY--SECQNAA 355 Query: 199 -LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL-IRHML 244 + +V SG F T PE+ K + GC+ + E L IR +L Sbjct: 356 QIYRKVTSGIKPASFNKVTD--PEV-KEIIEGCIRQNKSERLSIRDLL 400 >gi|50400798|sp|Q9UBE8|NLK_HUMAN Serine/threonine kinase NLK (Nemo-like kinase) (LAK1 protein) Length = 515 Score = 79.7 bits (195), Expect = 6e-15 Identities = 62/270 (22%), Positives = 118/270 (43%), Gaps = 26/270 (9%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-----IYLVTEYAS 74 VA+K + + + K++FRE++++ H +++ +++ + IY+VTE Sbjct: 152 VALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQ 211 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 ++ +V+ ++ + QI+ + + H I+HRD+K NLL+++N +KI D Sbjct: 212 S-DLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICD 270 Query: 135 FGFSNL--FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192 FG + + + + + Y APE+ G + +DIWS+G + L+ + F Sbjct: 271 FGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQ 330 Query: 193 GS----------------TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAEC 236 +L+ +R K I P L + E Sbjct: 331 AQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHI--LRGPHKQPSLPVLYTLSSQATHEA 388 Query: 237 EHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266 HL+ MLV DP+KR+S + H ++ G Sbjct: 389 VHLLCRMLVFDPSKRISAKDALAHPYLDEG 418 >gi|2851522|sp|P53778|MK12_HUMAN Mitogen-activated protein kinase 12 (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase-3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) Length = 367 Score = 79.7 bits (195), Expect = 6e-15 Identities = 68/267 (25%), Positives = 120/267 (44%), Gaps = 29/267 (10%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMI------YLVTEYA 73 VAIK + + E K+ +RE++++K + H ++I L V + + YLV + Sbjct: 53 VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM 112 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 G L+ H ++ E + Q++ + + H I+HRDLK NL ++ + +KI Sbjct: 113 --GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKIL 170 Query: 134 DFGF---SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 DFG ++ G ++ W Y APE+ VDIWS+G ++ ++ G Sbjct: 171 DFGLARQADSEMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL 225 Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGL-----------VPELDKRLKAGCLSIAE--CE 237 F GS + ++ P L +PEL+K+ A L+ A Sbjct: 226 FKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAV 285 Query: 238 HLIRHMLVLDPNKRLSMEQICKHKWMK 264 +L+ MLVLD +R++ + H + + Sbjct: 286 NLLEKMLVLDAEQRVTAGEALAHPYFE 312 >gi|12644292|sp|P49840|GSK3A_HUMAN Glycogen synthase kinase-3 alpha (GSK-3 alpha) Length = 483 Score = 79.7 bits (195), Expect = 6e-15 Identities = 85/315 (26%), Positives = 133/315 (42%), Gaps = 52/315 (16%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRL----YQVME 61 G + Q L ET++LVAIK + L ++ K RE+QIM+ L H +I+RL Y E Sbjct: 131 GVVYQARLAETRELVAIKKV----LQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGE 184 Query: 62 TERMIYL--VTEYASGGEIFDHLVAHGRMAEKE-----ARRKFKQIVTAVYFCHCRNIVH 114 + +YL V EY E + H A+ + Q+ ++ + H + + H Sbjct: 185 KKDELYLNLVLEYVP--ETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCH 242 Query: 115 RDLKAENLLLDANLNI-KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173 RD+K +NLL+D + + K+ DFG + G+ ++ S Y APEL G +D Sbjct: 243 RDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 302 Query: 174 IWSLGVVLYVLVCGALPFDGSTLQNLRARVLS-----------------GKFRIPFFMST 216 +WS G VL L+ G F G + + ++ +F+ P + Sbjct: 303 VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH 362 Query: 217 GLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLI 276 R +IA C L+ + P+ RLS + C H + FD L Sbjct: 363 PWTKVFKSRTPPE--AIALCSSLLEY----TPSSRLSPLEACAHSF---------FDELR 407 Query: 277 AECQQLKEERQVDPL 291 QL R + PL Sbjct: 408 CLGTQLPNNRPLPPL 422 >gi|125711|sp|P12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (p60-Src) (c-Src) Length = 536 Score = 79.7 bits (195), Expect = 6e-15 Identities = 63/197 (31%), Positives = 97/197 (49%), Gaps = 11/197 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + + E +E Q+MK L H +++LY V+ +E IY+VTEY S G + Sbjct: 295 VAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLL 350 Query: 80 DHLVAH-GRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 D L G+ + QI + + + N VHRDL+A N+L+ NL K+ADFG Sbjct: 351 DFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGL 410 Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS 194 + L + P + APE + K D+WS G++L L G +P+ G Sbjct: 411 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILLTELTTKGRVPYPGM 469 Query: 195 TLQNLRARVLSGKFRIP 211 + + +V G +R+P Sbjct: 470 VNREVLDQVERG-YRMP 485 >gi|37537965|sp|Q8TDX7|NEK7_HUMAN Serine/threonine-protein kinase Nek7 (NimA-related protein kinase 7) Length = 302 Score = 79.7 bits (195), Expect = 6e-15 Identities = 47/173 (27%), Positives = 85/173 (49%), Gaps = 8/173 (4%) Query: 30 LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-- 87 +D + +E+ ++K L HP++I+ Y + + +V E A G++ ++ H + Sbjct: 71 MDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDL-SRMIKHFKKQ 129 Query: 88 ---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF-TP 143 + E+ + F Q+ +A+ H R ++HRD+K N+ + A +K+ D G F + Sbjct: 130 KRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK 189 Query: 144 GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196 + G+P Y +PE Y+ K DIWSLG +LY + PF G + Sbjct: 190 TTAAHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQSPFYGDKM 241 >gi|2499600|sp|Q16539|MK14_HUMAN Mitogen-activated protein kinase 14 (Mitogen-activated protein kinase p38alpha) (MAP kinase p38alpha) (Cytokine suppressive anti-inflammatory drug binding protein) (CSAID binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A) Length = 360 Score = 79.3 bits (194), Expect = 8e-15 Identities = 79/332 (23%), Positives = 146/332 (43%), Gaps = 39/332 (11%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + F +T VA+K + + + K+ +RE++++K + H ++I L V R Sbjct: 36 GSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARS 95 Query: 66 ------IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKA 119 +YLVT G +++V ++ + + QI+ + + H +I+HRDLK Sbjct: 96 LEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKP 153 Query: 120 ENLLLDANLNIKIADFGFSNLF---TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176 NL ++ + +KI DFG + G + W Y APE+ + VDIWS Sbjct: 154 SNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWS 208 Query: 177 LGVVLYVLVCGALPFDGST-LQNLR-------------ARVLSGKFRIPFFMSTGLVPEL 222 +G ++ L+ G F G+ + L+ + +S + + S +P++ Sbjct: 209 VGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKM 268 Query: 223 D-KRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQ 281 + + G +A L+ MLVLD +KR++ Q H + DP+ + + Q Sbjct: 269 NFANVFIGANPLA--VDLLEKMLVLDSDKRITAAQALAHAYFAQYH-DPDDEPVADPYDQ 325 Query: 282 LKEERQV-----DPLNEDVLLAMEDMGLDKEQ 308 E R + L D +++ LD+E+ Sbjct: 326 SFESRDLLIDEWKSLTYDEVISFVPPPLDQEE 357 >gi|29840818|sp|Q9UKE5|TNIK_HUMAN TRAF2 and NCK interacting kinase Length = 1360 Score = 79.3 bits (194), Expect = 8e-15 Identities = 77/279 (27%), Positives = 129/279 (46%), Gaps = 42/279 (15%) Query: 2 QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61 QV KG ++ T QL AIK++D T +EE +K+ E+ ++K H I Y Sbjct: 38 QVYKGRHVK-----TGQLAAIKVMDVTGDEEEEIKQ---EINMLKKYSHHRNIATYYGAF 89 Query: 62 TER-------MIYLVTEYASGGEIFDHL--VAHGRMAEKEARRKFKQIVTAVYFCHCRNI 112 ++ ++LV E+ G + D + + E+ ++I+ + H + Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149 Query: 113 VHRDLKAENLLLDANLNIKIADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE---- 166 +HRD+K +N+LL N +K+ DFG S T G+ T+ G+P + APE+ E Sbjct: 150 IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPDA 208 Query: 167 -YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKR 225 YD K D+WSLG+ + GA P + +RA L + P R Sbjct: 209 TYDF-KSDLWSLGITAIEMAEGAPPL--CDMHPMRALFLIPRNPAP-------------R 252 Query: 226 LKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 LK+ S + + I LV + ++R + EQ+ KH +++ Sbjct: 253 LKSKKWS-KKFQSFIESCLVKNHSQRPATEQLMKHPFIR 290 >gi|41688799|sp|Q9Y3S1|WNK2_HUMAN Serine/threonine-protein kinase WNK2 (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2) (P/OKcl.13) Length = 2297 Score = 79.3 bits (194), Expect = 8e-15 Identities = 52/171 (30%), Positives = 89/171 (52%), Gaps = 13/171 (7%) Query: 28 TQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET----ERMIYLVTEYASGGEIFDHLV 83 T+L+ + K+ E +++K L HP+I+R Y E+ +R I LVTE + G + +L Sbjct: 232 TKLERQRFKE---EAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLK 288 Query: 84 AHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL-NIKIADFGFSNL 140 M K R +QI+ + F H R I+HRDLK +N+ + ++KI D G + L Sbjct: 289 RFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 348 Query: 141 FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 K+ G+P + APE++E E+ VD+++ G+ + + P+ Sbjct: 349 -KRASFAKSVIGTPEFMAPEMYE--EHYDESVDVYAFGMCMLEMATSEYPY 396 Score = 30.8 bits (68), Expect = 3.4 Identities = 40/169 (23%), Positives = 58/169 (34%), Gaps = 32/169 (18%) Query: 850 QQPPHYTTSALQQALLSPTPPDYTRHQQASSPTPPHGYAHQPALMHSESMEEDCSCEGAK 909 +QPP ++ + L S P + QQ S P P + S + Sbjct: 1378 KQPPD--SAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALP--- 1432 Query: 910 DGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQEL---------------G 954 QD + +T T S GGPG P+ L + +Q L G Sbjct: 1433 ---QDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVG 1489 Query: 955 IHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPA 1003 + P P AA +++ REP+ P A E H+G PA Sbjct: 1490 LAPCTPAPEAASTRDASAPREPL---------PPPAPEPSPHSGTPQPA 1529 >gi|29427834|sp|Q8N4C8|M4K6_HUMAN Mitogen-activated protein kinase kinase kinase kinase 6 (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 78.6 bits (192), Expect = 1e-14 Identities = 63/205 (30%), Positives = 101/205 (49%), Gaps = 26/205 (12%) Query: 2 QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61 QV KG ++ T QL AIK++D T+ +EE +K+ E+ ++K H I Y Sbjct: 38 QVYKGRHVK-----TGQLAAIKVMDVTEDEEEEIKQ---EINMLKKYSHHRNIATYYGAF 89 Query: 62 TER-------MIYLVTEYASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNI 112 ++ ++LV E+ G + D + A KE + ++I+ + H + Sbjct: 90 IKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKV 149 Query: 113 VHRDLKAENLLLDANLNIKIADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE---- 166 +HRD+K +N+LL N +K+ DFG S T G+ T+ G+P + APE+ E Sbjct: 150 IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPDA 208 Query: 167 -YDGPKVDIWSLGVVLYVLVCGALP 190 YD + DIWSLG+ + GA P Sbjct: 209 TYD-YRSDIWSLGITAIEMAEGAPP 232 >gi|400274|sp|Q02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) Length = 393 Score = 78.2 bits (191), Expect = 2e-14 Identities = 66/265 (24%), Positives = 120/265 (45%), Gaps = 39/265 (14%) Query: 37 KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRK 96 +I RE+Q++ P+I+ Y ++ I + E+ GG + L GR+ E+ + Sbjct: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169 Query: 97 FKQIVTAV-YFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLL----KTWC 151 ++ + Y I+HRD+K N+L+++ IK+ DFG S GQL+ ++ Sbjct: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSFV 224 Query: 152 GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---DGSTLQNLRARVLSG-- 206 G+ Y +PE +G Y + DIWS+G+ L + G P D L+ + + G Sbjct: 225 GTRSYMSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA 283 Query: 207 -----KFRIP-----------------FFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244 + R P F + +V E +L +G S+ E + + L Sbjct: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL-EFQDFVNKCL 342 Query: 245 VLDPNKRLSMEQICKHKWMKLGDAD 269 + +P +R ++Q+ H ++K DA+ Sbjct: 343 IKNPAERADLKQLMVHAFIKRSDAE 367 >gi|20141296|sp|P08631|HCK_HUMAN Tyrosine-protein kinase HCK (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 526 Score = 77.8 bits (190), Expect = 2e-14 Identities = 55/185 (29%), Positives = 93/185 (50%), Gaps = 12/185 (6%) Query: 34 NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEA 93 +++ E +MK L H +++L+ V+ T+ IY++TE+ + G + D L + K+ Sbjct: 298 SVEAFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDE--GSKQP 354 Query: 94 RRKF----KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKT 149 K QI + F RN +HRDL+A N+L+ A+L KIADFG + + + Sbjct: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414 Query: 150 WCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGSTLQNLRARVLSG 206 P + APE + K D+WS G++L +V G +P+ G + + R L Sbjct: 415 EGAKFPIKWTAPEAINFGSFT-IKSDVWSFGILLMEIVTYGRIPYPGMSNPEV-IRALER 472 Query: 207 KFRIP 211 +R+P Sbjct: 473 GYRMP 477 >gi|125370|sp|P06241|FYN_HUMAN Proto-oncogene tyrosine-protein kinase FYN (P59-FYN) (SYN) (SLK) Length = 537 Score = 77.4 bits (189), Expect = 3e-14 Identities = 62/197 (31%), Positives = 96/197 (48%), Gaps = 11/197 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + + E+ E QIMK L H +++LY V+ +E IY+VTEY + G + Sbjct: 296 VAIKTLKPGTMSPESF---LEEAQIMKKLKHDKLVQLYAVV-SEEPIYIVTEYMNKGSLL 351 Query: 80 DHLV-AHGRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 D L GR + Q+ + + N +HRDL++ N+L+ L KIADFG Sbjct: 352 DFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGL 411 Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS 194 + L + P + APE + K D+WS G++L LV G +P+ G Sbjct: 412 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILLTELVTKGRVPYPGM 470 Query: 195 TLQNLRARVLSGKFRIP 211 + + +V G +R+P Sbjct: 471 NNREVLEQVERG-YRMP 486 >gi|45593475|sp|Q12851|M4K2_HUMAN Mitogen-activated protein kinase kinase kinase kinase 2 (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8 interacting protein) (B lymphocyte serine/threonine-protein kinase) Length = 819 Score = 77.4 bits (189), Expect = 3e-14 Identities = 62/249 (24%), Positives = 119/249 (47%), Gaps = 20/249 (8%) Query: 16 TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 T +L A+KI+ +LD +++ + +E+ I++ HP+++ +++ E+ Sbjct: 37 TSELAAVKIV---KLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCG 93 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134 GG + + A G + E++ ++ + ++ H + +HRD+K NLLL ++K+AD Sbjct: 94 GGSLQEIYHATGPLEERQIAYVCRERLKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLAD 153 Query: 135 FGFSNLFTPG-QLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 FG S T +++ G+P + APE+ E K D+W+LG+ L G L Sbjct: 154 FGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIEL--GELQP 211 Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251 L +RA +L K S+ P+L + + H ++ L +P KR Sbjct: 212 PLFHLHPMRALMLMSK-------SSFQPPKLRDKTR----WTQNFHHFLKLALTKNPKKR 260 Query: 252 LSMEQICKH 260 + E++ +H Sbjct: 261 PTAEKLLQH 269 >gi|543848|sp|P35626|ARBK2_HUMAN Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (G-protein coupled receptor kinase 3) Length = 688 Score = 77.4 bits (189), Expect = 3e-14 Identities = 54/182 (29%), Positives = 95/182 (52%), Gaps = 7/182 (3%) Query: 15 ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH----PHIIRLYQVMETERMIYLVT 70 +T ++ A+K +DK ++ + + + +IM L P I+ + T + + Sbjct: 212 DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFIL 271 Query: 71 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130 + +GG++ HL HG +EKE R +I+ + H R +V+RDLK N+LLD + + Sbjct: 272 DLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHVHNRFVVYRDLKPANILLDEHGHA 331 Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGAL 189 +I+D G + F+ + + G+ Y APE+ + G YD D +SLG +L+ L+ G Sbjct: 332 RISDLGLACDFSKKKPHAS-VGTHGYMAPEVLQKGTAYDS-SADWFSLGCMLFKLLRGHS 389 Query: 190 PF 191 PF Sbjct: 390 PF 391 >gi|1174630|sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec Length = 631 Score = 77.4 bits (189), Expect = 3e-14 Identities = 53/191 (27%), Positives = 90/191 (47%), Gaps = 8/191 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK I + + EE+ E ++M L HP +++LY V ++ IY+VTE+ G + Sbjct: 395 VAIKAIREGAMCEEDF---IEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLL 451 Query: 80 DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 + L G + + + + + + +HRDL A N L+ +K++DFG + Sbjct: 452 NFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMA 511 Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195 F Q + P + PE+F + K D+WS GV+++ V G +PF+ T Sbjct: 512 RYFLDDQYTSSSGAKFPVKWCPPEVFNYSRFSS-KSDVWSFGVLMWEVFTEGRMPFEKYT 570 Query: 196 LQNLRARVLSG 206 + V G Sbjct: 571 NYEVVTMVTRG 581 >gi|37537993|sp|Q9HC98|NEK6_HUMAN Serine/threonine-protein kinase Nek6 (NimA-related protein kinase 6) (Protein kinase SID6-1512) Length = 313 Score = 77.0 bits (188), Expect = 4e-14 Identities = 50/186 (26%), Positives = 91/186 (48%), Gaps = 7/186 (3%) Query: 17 KQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 ++ VA+K + ++ D + + +E+ ++K L HP+II+ + + +V E A Sbjct: 68 RKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADA 127 Query: 76 GEIFDHLVAHGR----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 G++ + + + E+ + F Q+ +AV H R ++HRD+K N+ + A +K Sbjct: 128 GDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVK 187 Query: 132 IADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 + D G F + + G+P Y +PE Y+ K DIWSLG +LY + P Sbjct: 188 LGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQSP 246 Query: 191 FDGSTL 196 F G + Sbjct: 247 FYGDKM 252 >gi|585361|sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 77.0 bits (188), Expect = 4e-14 Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 9/198 (4%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 K VAIK I + + EE+ E ++M L HP +++LY V + I LV E+ G Sbjct: 385 KDKVAIKTIREGAMSEEDF---IEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHG 441 Query: 77 EIFDHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 + D+L G A + + + + ++HRDL A N L+ N IK++DF Sbjct: 442 CLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDF 501 Query: 136 GFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFD 192 G + Q + P +A+PE+F Y K D+WS GV+++ V G +P++ Sbjct: 502 GMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS-KSDVWSFGVLMWEVFSEGKIPYE 560 Query: 193 GSTLQNLRARVLSGKFRI 210 + + + +G FR+ Sbjct: 561 NRSNSEVVEDISTG-FRL 577 >gi|22653927|sp|O94921|PFTK1_HUMAN Serine/threonine-protein kinase PFTAIRE-1 Length = 469 Score = 76.6 bits (187), Expect = 5e-14 Identities = 63/262 (24%), Positives = 113/262 (43%), Gaps = 19/262 (7%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 +LVA+K+I + Q +E RE ++K L H +I+ L+ ++ T+ + LV EY + Sbjct: 159 KLVALKVI-RLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHT-D 216 Query: 78 IFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136 + ++ H G + + Q++ + + H R I+HRDLK +NLL+ +K+ADFG Sbjct: 217 LCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFG 276 Query: 137 FSNL-FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG-S 194 + P + Y P++ G +D+W +G + ++ G F G Sbjct: 277 LARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMK 336 Query: 195 TLQNLRARVL-----------SGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH---LI 240 +Q+ R+ G +P F K L+ ++ H L Sbjct: 337 DIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLA 396 Query: 241 RHMLVLDPNKRLSMEQICKHKW 262 +L P RLS + H++ Sbjct: 397 SKLLQCSPKNRLSAQAALSHEY 418 >gi|1705485|sp|P51451|BLK_HUMAN Tyrosine-protein kinase BLK (B lymphocyte kinase) (p55-BLK) Length = 505 Score = 76.6 bits (187), Expect = 5e-14 Identities = 66/215 (30%), Positives = 101/215 (46%), Gaps = 12/215 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + + + E E +MK L H ++RLY V+ T+ IY+VTEY + G + Sbjct: 266 VAIKTLKEGTMSPE---AFLGEANMMKALQHERLVRLYAVV-TKEPIYIVTEYMARGCLL 321 Query: 80 DHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137 D L R++ QI + + N +HRDL+A N+L+ L KIADFG Sbjct: 322 DFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGL 381 Query: 138 SNLFTPGQLLKTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195 + + + P + APE + K D+WS GV+L V+ G +P+ G + Sbjct: 382 ARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFT-IKADVWSFGVLLMEVVTYGRVPYPGMS 440 Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGC 230 + R L +R+P PEL + + A C Sbjct: 441 NPEV-IRNLERGYRMP--RPDTCPPELYRGVIAEC 472 >gi|28201830|sp|Q96RU7|TRIB3_HUMAN Tribbles homolog 3 (TRB-3) (Neuronal cell death inducible putative kinase) Length = 358 Score = 76.3 bits (186), Expect = 7e-14 Identities = 58/219 (26%), Positives = 95/219 (43%), Gaps = 23/219 (10%) Query: 50 HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC 109 H H+ R +V+ +++Y + G++ + + R+ E EA F+Q+ TA+ CH Sbjct: 117 HKHVARPTEVLAGTQLLYAFFT-RTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQ 175 Query: 110 RNIVHRDLKAENLLLDANLNIKIADFGFSN---LFTPGQLLKTWCGSPPYAAPELFEGK- 165 +V RDLK + K+ + L P L P Y PE+ + Sbjct: 176 HGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRA 235 Query: 166 EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKR 225 Y G D+WSLGV L+ ++ G PF S L ++ G + +P Sbjct: 236 SYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALP-------------- 281 Query: 226 LKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 AG + A C L+R +L +P +RL+ I H W++ Sbjct: 282 --AGLSAPARC--LVRCLLRREPAERLTATGILLHPWLR 316 >gi|547759|sp|Q06187|BTK_HUMAN Tyrosine-protein kinase BTK (Bruton's tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 659 Score = 76.3 bits (186), Expect = 7e-14 Identities = 48/191 (25%), Positives = 94/191 (49%), Gaps = 8/191 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK+I + + E+ + E ++M L H +++LY V +R I+++TEY + G + Sbjct: 427 VAIKMIKEGSMSED---EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLL 483 Query: 80 DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 ++L R ++ K + A+ + + +HRDL A N L++ +K++DFG S Sbjct: 484 NYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS 543 Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195 + + P ++ PE+ ++ K DIW+ GV+++ + G +P++ T Sbjct: 544 RYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSS-KSDIWAFGVLMWEIYSLGKMPYERFT 602 Query: 196 LQNLRARVLSG 206 + G Sbjct: 603 NSETAEHIAQG 613 >gi|29427585|sp|O95819|M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck interacting kinase) Length = 1239 Score = 76.3 bits (186), Expect = 7e-14 Identities = 79/282 (28%), Positives = 129/282 (45%), Gaps = 37/282 (13%) Query: 2 QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61 QV KG ++ T QL AIK++D T+ +EE +K E+ ++K H I Y Sbjct: 38 QVYKGRHVK-----TGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHHRNIATYYGAF 89 Query: 62 TER-------MIYLVTEYASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRN 111 ++ ++LV E+ G I D LV + + + E ++I+ + H + Sbjct: 90 IKKSPPGHDDQLWLVMEFCGAGSITD-LVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 148 Query: 112 IVHRDLKAENLLLDANLNIKIADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE--- 166 ++HRD+K +N+LL N +K+ DFG S T G+ T+ G+P + APE+ E Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPD 207 Query: 167 --YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDK 224 YD + D+WS G+ + GA P + +RA L + P S + Sbjct: 208 ATYD-YRSDLWSCGITAIEMAEGAPPL--CDMHPMRALFLIPRNPPPRLKSKKWSKKFFS 264 Query: 225 RLKAGCL-----SIAECEHLIRHMLVLD-PNKRLSMEQICKH 260 ++ GCL E L++H + D PN+R Q+ H Sbjct: 265 FIE-GCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDH 305 >gi|2499633|sp|Q13163|MP2K5_HUMAN Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) Length = 438 Score = 75.9 bits (185), Expect = 9e-14 Identities = 50/174 (28%), Positives = 86/174 (49%), Gaps = 7/174 (4%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + + + + +++A+K+I + E K+I E++I+ +II Y E Sbjct: 178 GTVYKAYHVPSGKILAVKVI-LLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENR 236 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125 I + TE+ GG L + +M E R +V + + I+HRD+K N+L++ Sbjct: 237 ISICTEFMDGGS----LDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVN 292 Query: 126 ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV 179 +K+ DFG S + KT+ G+ Y APE G++Y G D+WSLG+ Sbjct: 293 TRGQVKLCDFGVSTQLV-NSIAKTYVGTNAYMAPERISGEQY-GIHSDVWSLGI 344 >gi|125870|sp|P07947|YES_HUMAN Proto-oncogene tyrosine-protein kinase YES (p61-YES) (C-YES) Length = 543 Score = 75.9 bits (185), Expect = 9e-14 Identities = 65/205 (31%), Positives = 96/205 (46%), Gaps = 27/205 (13%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + + E +E QIMK L H ++ LY V+ +E IY+VTE+ S G + Sbjct: 302 VAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLL 357 Query: 80 DHLVAHGRMAEKEARRKF----------KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 D L KE K+ QI + + N +HRDL+A N+L+ NL Sbjct: 358 DFL--------KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLV 409 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC- 186 KIADFG + L + P + APE + K D+WS G++ LV Sbjct: 410 CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILQTELVTK 468 Query: 187 GALPFDGSTLQNLRARVLSGKFRIP 211 G +P+ G + + +V G +R+P Sbjct: 469 GRVPYPGMVNREVLEQVERG-YRMP 492 >gi|30316147|sp|Q9Y4K4|M4K5_HUMAN Mitogen-activated protein kinase kinase kinase kinase 5 (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS) Length = 846 Score = 75.9 bits (185), Expect = 9e-14 Identities = 67/265 (25%), Positives = 124/265 (46%), Gaps = 22/265 (8%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T +L A+KII D+ +L I +E+ ++K H +I+ + + +++ EY G Sbjct: 42 TGELAAVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 G + D G ++E + ++ + + + H + +HRD+K N+LL + ++K+ADF Sbjct: 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADF 159 Query: 136 GFSNLFTPG-QLLKTWCGSPPYAAPELFEGKEYDG--PKVDIWSLGVVLYVLVCGALPFD 192 G + T K++ G+P + APE+ ++ G DIW++G+ L G L Sbjct: 160 GVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIEL--GELQPP 217 Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252 L +RA L K S P+L + K + + ++ L +P KR Sbjct: 218 MFDLHPMRALFLMSK-------SNFQPPKLKDKTKWS----STFHNFVKIALTKNPKKRP 266 Query: 253 SMEQICKHKWMKLGDADPNFDRLIA 277 + E++ H ++ A P R +A Sbjct: 267 TAERLLTHTFV----AQPGLSRALA 287 >gi|114152|sp|P25098|ARBK1_HUMAN Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled receptor kinase 2) Length = 689 Score = 75.5 bits (184), Expect = 1e-13 Identities = 52/183 (28%), Positives = 96/183 (52%), Gaps = 7/183 (3%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH----PHIIRLYQVMETERMIYLV 69 ++T ++ A+K +DK ++ + + + +IM L P I+ + T + + Sbjct: 211 RDTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFI 270 Query: 70 TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 + +GG++ HL HG +E + R +I+ + H R +V+RDLK N+LLD + + Sbjct: 271 LDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH 330 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGA 188 ++I+D G + F+ + + G+ Y APE+ + G YD D +SLG +L+ L+ G Sbjct: 331 VRISDLGLACDFSKKKPHAS-VGTHGYMAPEVLQKGVAYDS-SADWFSLGCMLFKLLRGH 388 Query: 189 LPF 191 PF Sbjct: 389 SPF 391 >gi|125387|sp|P29320|EPHA3_HUMAN Ephrin type-A receptor 3 precursor (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 75.5 bits (184), Expect = 1e-13 Identities = 59/198 (29%), Positives = 96/198 (48%), Gaps = 9/198 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + K E+ + E IM HP+IIRL V+ + + +VTEY G + Sbjct: 650 VAIKTL-KVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLD 708 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L H + + + I + + + VHRDL A N+L+++NL K++DFG S Sbjct: 709 SFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLS 768 Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193 + P T G P + +PE +++ D+WS G+VL+ V+ G P+ Sbjct: 769 RVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSAS-DVWSYGIVLWEVMSYGERPYWE 827 Query: 194 STLQNLRARVLSGKFRIP 211 + Q++ V G +R+P Sbjct: 828 MSNQDVIKAVDEG-YRLP 844 >gi|3183518|sp|Q05397|FAK1_HUMAN Focal adhesion kinase 1 (FADK 1) (pp125FAK) (Protein-tyrosine kinase 2) Length = 1052 Score = 75.5 bits (184), Expect = 1e-13 Identities = 55/196 (28%), Positives = 94/196 (47%), Gaps = 8/196 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK D +K +E M+ HPHI++L V+ TE ++++ E + GE+ Sbjct: 451 VAIKTCKNCTSDSVR-EKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELR 508 Query: 80 DHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L + + + Q+ TA+ + + VHRD+ A N+L+ +N +K+ DFG S Sbjct: 509 SFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLS 568 Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195 K G P + APE + + D+W GV ++ +L+ G PF G Sbjct: 569 RYMEDSTYYKASKGKLPIKWMAPESINFRRFTSAS-DVWMFGVCMWEILMHGVKPFQGVK 627 Query: 196 LQNLRARVLSGKFRIP 211 ++ R+ +G+ R+P Sbjct: 628 NNDVIGRIENGE-RLP 642 >gi|400127|sp|P07332|FES_HUMAN Proto-oncogene tyrosine-protein kinase Fes/Fps (C-Fes) Length = 822 Score = 75.5 bits (184), Expect = 1e-13 Identities = 67/231 (29%), Positives = 101/231 (43%), Gaps = 13/231 (5%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G + L+ LVA+K +T L + K +E +I+K HP+I+RL V ++ Sbjct: 573 GEVFSGRLRADNTLVAVKSCRET-LPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQP 631 Query: 66 IYLVTEYASGGEIFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124 IY+V E GG+ L G R+ K + + + + +HRDL A N L+ Sbjct: 632 IYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLV 691 Query: 125 DANLNIKIADFGFSNLFTPGQLLKTWCGS----PPYAAPELFEGKEYDGPKVDIWSLGVV 180 +KI+DFG S G + GS + APE Y + D+WS G++ Sbjct: 692 TEKNVLKISDFGMSREEADGVYAASG-GSRQVPVKWTAPEALNYGRYSS-ESDVWSFGIL 749 Query: 181 LY-VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGC 230 L+ GA P+ + Q R V G R+P L P+ RL C Sbjct: 750 LWETFSLGASPYPNLSNQQTREFVEKGG-RLP---CPELCPDAVFRLMEQC 796 Score = 31.6 bits (70), Expect = 2.0 Identities = 19/93 (20%), Positives = 45/93 (48%), Gaps = 1/93 (1%) Query: 1170 PVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAE 1229 P++Q W + +TEGL + + + E++ + L ++ Q+ + Y ++ + L+ E Sbjct: 68 PISQS-WAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQE 126 Query: 1230 LQEGARQKLHELQEKLSPLGEEMRDRARAHVDA 1262 L + Q + +L+ + L + R + +A Sbjct: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA 159 >gi|21263659|sp|Q8WTQ7|GRK7_HUMAN G protein-coupled receptor kinase 7 (G protein-coupled receptor kinase GRK7) Length = 553 Score = 75.5 bits (184), Expect = 1e-13 Identities = 52/182 (28%), Positives = 92/182 (50%), Gaps = 3/182 (1%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71 ++ T ++ A K +DK +L ++ +K+ E +I++ + P I+ L E++ + LV Sbjct: 210 VKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMS 269 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 +GG++ H+ G +R F QI + H IV+RD+K EN+LLD N Sbjct: 270 LMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGN 329 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 +++D G + G+ + G+ Y APE+ K VD +++G +Y +V G Sbjct: 330 CRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRT 389 Query: 190 PF 191 PF Sbjct: 390 PF 391 >gi|399448|sp|P31152|MK04_HUMAN Mitogen-activated protein kinase 4 (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) Length = 557 Score = 74.7 bits (182), Expect = 2e-13 Identities = 79/355 (22%), Positives = 149/355 (41%), Gaps = 57/355 (16%) Query: 4 VKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE 63 V G ++ + VA+K I + D ++K RE++I++ L H +I+++Y+V+ + Sbjct: 30 VNGLVLSAVDSRACRKVAVKKIALS--DARSMKHALREIKIIRRLDHDNIVKVYEVLGPK 87 Query: 64 -----------RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 112 + Y+V EY L+ G +AE+ A+ Q++ + + H N+ Sbjct: 88 GTDLQGELFKFSVAYIVQEYMETD--LARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANV 145 Query: 113 VHRDLKAENLLLDA-NLNIKIADFGFSNL----FTPGQLLKTWCGSPPYAAPELFEGKEY 167 +HRDLK N+ + +L +KI DFG + + ++ L + Y +P L Sbjct: 146 LHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNN 205 Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGS-----------TLQNLRARVLSGKFRI-PFFMS 215 +D+W+ G +L ++ G + F G+ T+ +R R+ P F+S Sbjct: 206 YTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVS 265 Query: 216 T---------GLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266 + L+PE++ +E + +L +P RL+ E +H +M Sbjct: 266 STWEVKRPLRKLLPEVN----------SEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPY 315 Query: 267 DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQPDGTLNLDSD 321 + E R D +++ VL+A L T ++L SD Sbjct: 316 SCPED------EPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSD 364 >gi|729887|sp|P41240|CSK_HUMAN Tyrosine-protein kinase CSK (C-SRC kinase) (Protein-tyrosine kinase CYL) Length = 450 Score = 74.3 bits (181), Expect = 3e-13 Identities = 55/192 (28%), Positives = 96/192 (50%), Gaps = 15/192 (7%) Query: 23 KIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-IYLVTEYASGGEIFDH 81 K+ K ++ + E +M L H ++++L V+ E+ +Y+VTEY + G + D+ Sbjct: 218 KVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDY 277 Query: 82 LVAHGR-MAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-- 137 L + GR + + KF + A+ + N VHRDL A N+L+ + K++DFG Sbjct: 278 LRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 Query: 138 --SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS 194 S+ G+L W APE K++ K D+WS G++L+ + G +P+ Sbjct: 338 EASSTQDTGKLPVKW------TAPEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRI 390 Query: 195 TLQNLRARVLSG 206 L+++ RV G Sbjct: 391 PLKDVVPRVEKG 402 >gi|20141243|sp|P50750|CDK9_HUMAN Cell division protein kinase 9 (Cyclin-dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4) Length = 372 Score = 74.3 bits (181), Expect = 3e-13 Identities = 68/283 (24%), Positives = 125/283 (44%), Gaps = 45/283 (15%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-------- 65 ++T Q VA+K + E RE++I+++L H +++ L ++ T+ Sbjct: 39 RKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGS 98 Query: 66 IYLVTEYAS---GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENL 122 IYLV ++ G + + LV + E +R + ++ +Y+ H I+HRD+KA N+ Sbjct: 99 IYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANV 155 Query: 123 LLDANLNIKIADFGFSNLFT----------PGQLLKTWCGSPPYAAPELFEGKEYDGPKV 172 L+ + +K+ADFG + F+ +++ W Y PEL G+ GP + Sbjct: 156 LITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW-----YRPPELLLGERDYGPPI 210 Query: 173 DIWSLGVVLYVLVCGALPFDGSTLQNLRARV--LSGKFRIPFF-------------MSTG 217 D+W G ++ + + +T Q+ A + L G + + G Sbjct: 211 DLWGAGCIMAEMWTRSPIMQANTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKG 270 Query: 218 LVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKH 260 ++ RLKA + LI +LVLDP +R+ + H Sbjct: 271 QKRKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRIDSDDALNH 312 >gi|1706628|sp|P54756|EPHA5_HUMAN Ephrin type-A receptor 5 precursor (Tyrosine-protein kinase receptor EHK-1) (Eph homology kinase-1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 74.3 bits (181), Expect = 3e-13 Identities = 59/198 (29%), Positives = 95/198 (47%), Gaps = 9/198 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + K E+ + E IM HP+II L V+ + + +VTEY G + Sbjct: 704 VAIKTL-KVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLD 762 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L + G+ + + I + + VHRDL A N+L+++NL K++DFG S Sbjct: 763 TFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLS 822 Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDG 193 + P T G P + APE +++ D+WS G+V++ +V G P+ Sbjct: 823 RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSAS-DVWSYGIVMWEVVSYGERPYWE 881 Query: 194 STLQNLRARVLSGKFRIP 211 T Q++ V G +R+P Sbjct: 882 MTNQDVIKAVEEG-YRLP 898 >gi|46577075|sp|Q8NEV4|MYO3A_HUMAN Myosin IIIA Length = 1616 Score = 73.9 bits (180), Expect = 4e-13 Identities = 76/275 (27%), Positives = 121/275 (44%), Gaps = 37/275 (13%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63 G + + ++ Q A+KI+D +DEE I E I+K L HP+++R Y + + Sbjct: 33 GKVFKVLNKKNGQKAAVKILDPIHDIDEE----IEAEYNILKALSDHPNVVRFYGIYFKK 88 Query: 64 RMI-----YLVTEYASGGEIFD----HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVH 114 + +LV E SGG + D L RM+E + + + H +H Sbjct: 89 DKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIH 148 Query: 115 RDLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKE-----YD 168 RD+K N+LL +K+ DFG S L + T G+P + APE+ ++ YD Sbjct: 149 RDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYD 208 Query: 169 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKA 228 + D WSLG+ L G P + L +RA F+IP +L+ Sbjct: 209 A-RCDTWSLGITAIELGDGDPPL--ADLHPMRA-----LFKIP--------RNPPPKLRQ 252 Query: 229 GCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263 L AE I L D KR ++ ++ +HK++ Sbjct: 253 PELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287 >gi|18202489|sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (Leucine-zipper protein kinase) (ZPK) Length = 859 Score = 73.9 bits (180), Expect = 4e-13 Identities = 44/151 (29%), Positives = 78/151 (51%), Gaps = 1/151 (0%) Query: 41 EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQI 100 +++ ++ L HP+II V ++ E+ + G++++ L A + I Sbjct: 161 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGI 220 Query: 101 VTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPE 160 + + H I+HRDLK+ N+L+ + +KI+DFG S + ++ G+ + APE Sbjct: 221 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 280 Query: 161 LFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191 + E KVDIWS GVVL+ L+ G +P+ Sbjct: 281 VIR-NEPVSEKVDIWSFGVVLWELLTGEIPY 310 >gi|20455502|sp|P49841|GSK3B_HUMAN Glycogen synthase kinase-3 beta (GSK-3 beta) Length = 420 Score = 73.6 bits (179), Expect = 5e-13 Identities = 63/202 (31%), Positives = 98/202 (48%), Gaps = 20/202 (9%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRL----YQVME 61 G + Q L ++ +LVAIK + L ++ K RE+QIM+ L H +I+RL Y E Sbjct: 68 GVVYQAKLCDSGELVAIKKV----LQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGE 121 Query: 62 TERMIYL--VTEYASGGEIFDHLVAHGRMAEKE-----ARRKFKQIVTAVYFCHCRNIVH 114 + +YL V +Y E + H A++ + Q+ ++ + H I H Sbjct: 122 KKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICH 179 Query: 115 RDLKAENLLLDANLNI-KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173 RD+K +NLLLD + + K+ DFG + G+ ++ S Y APEL G +D Sbjct: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 239 Query: 174 IWSLGVVLYVLVCGALPFDGST 195 +WS G VL L+ G F G + Sbjct: 240 VWSAGCVLAELLLGQPIFPGDS 261 >gi|48428273|sp|Q9UPZ9|ICK_HUMAN Serine/threonine kinase ICK (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 73.2 bits (178), Expect = 6e-13 Identities = 73/273 (26%), Positives = 117/273 (42%), Gaps = 31/273 (11%) Query: 15 ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74 E+ +L+AIK + + E + REV+ +K L H ++++L +V+ +Y + EY Sbjct: 25 ESGELIAIKKMKRKFYSWEECMNL-REVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMK 83 Query: 75 GGEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 ++ + ++ + A R QI+ + F H HRDLK ENLL +KIA Sbjct: 84 EN-LYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIA 142 Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVVL---YVL----- 184 DFG + + + Y APE L Y P +D+W++G ++ Y L Sbjct: 143 DFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSP-IDVWAVGCIMAEVYTLRPLFP 201 Query: 185 ----------VCGALPFDGSTLQNLRARVLSG-KFRIPFFMSTGLVPELDKRLKAGCLSI 233 +C L T ++ S FR P VP K L S Sbjct: 202 GASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWP-----QCVPNNLKTLIPNASS- 255 Query: 234 AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266 E L+R ML DP KR + Q ++ + ++G Sbjct: 256 -EAVQLLRDMLQWDPKKRPTASQALRYPYFQVG 287 >gi|125358|sp|P09769|FGR_HUMAN Proto-oncogene tyrosine-protein kinase FGR (P55-FGR) (C-FGR) Length = 529 Score = 73.2 bits (178), Expect = 6e-13 Identities = 53/176 (30%), Positives = 86/176 (48%), Gaps = 7/176 (3%) Query: 36 KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLV-AHGR-MAEKEA 93 K E Q+MK+L H +++LY V+ +E IY+VTE+ G + D L G+ + + Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVV-SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQL 359 Query: 94 RRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS 153 Q+ + + N +HRDL+A N+L+ L KIADFG + L + Sbjct: 360 VDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSK 419 Query: 154 PP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGSTLQNLRARVLSG 206 P + APE + K D+WS G++L L+ G +P+ G + + +V G Sbjct: 420 FPIKWTAPEAALFGRFT-IKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQG 474 >gi|120049|sp|P21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 precursor (FGFR-2) (Keratinocyte growth factor receptor 2) Length = 821 Score = 72.8 bits (177), Expect = 8e-13 Identities = 58/201 (28%), Positives = 100/201 (49%), Gaps = 23/201 (11%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI 78 VA+K++ K E++L + E+++MKM+ H +II L + +Y++ EYAS G + Sbjct: 514 VAVKML-KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 572 Query: 79 FDHLVAHGRMAEK---------EARRKFKQIVTAVY-------FCHCRNIVHRDLKAENL 122 ++L A + E + FK +V+ Y + + +HRDL A N+ Sbjct: 573 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 632 Query: 123 LLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGV 179 L+ N +KIADFG + ++ KT G P + APE + Y + D+WS GV Sbjct: 633 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT-HQSDVWSFGV 691 Query: 180 VLY-VLVCGALPFDGSTLQNL 199 +++ + G P+ G ++ L Sbjct: 692 LMWEIFTLGGSPYPGIPVEEL 712 >gi|232066|sp|P27361|MK03_HUMAN Mitogen-activated protein kinase 3 (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule-associated protein-2 kinase) Length = 379 Score = 72.4 bits (176), Expect = 1e-12 Identities = 62/271 (22%), Positives = 117/271 (43%), Gaps = 27/271 (9%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM-----ETERMIYLVTE 71 K VAIK I + + ++ RE+QI+ H ++I + ++ E R +Y+V + Sbjct: 65 KTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD 123 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131 L+ +++ QI+ + + H N++HRDLK NLL++ ++K Sbjct: 124 LMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLK 181 Query: 132 IADFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187 I DFG + + P L + + Y APE+ + +DIWS+G +L ++ Sbjct: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241 Query: 188 ALPFDGSTLQNLRARVLSGKFRIPF---------FMSTGLVPELDKRLKAGCLSI----- 233 F G + +L G P + + L + K + Sbjct: 242 RPIFPGKHYLDQLNHIL-GILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300 Query: 234 AECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 ++ L+ ML +PNKR+++E+ H +++ Sbjct: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLE 331 >gi|1706663|sp|P54762|EPHB1_HUMAN Ephrin type-B receptor 1 precursor (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 72.4 bits (176), Expect = 1e-12 Identities = 55/200 (27%), Positives = 94/200 (47%), Gaps = 11/200 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + K E+ + E IM HP+IIRL V+ R + ++TE+ G + Sbjct: 648 VAIKTL-KAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L + G+ + + I + + N VHRDL A N+L+++NL K++DFG S Sbjct: 707 SFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLS 766 Query: 139 NLFTPGQLLKTWCGS------PPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF 191 T+ S + APE +++ D+WS G+V++ V+ G P+ Sbjct: 767 RYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSFGERPY 825 Query: 192 DGSTLQNLRARVLSGKFRIP 211 + Q++ + +R+P Sbjct: 826 WDMSNQDV-INAIEQDYRLP 844 >gi|1705722|sp|P50613|CDK7_HUMAN Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1) Length = 346 Score = 72.4 bits (176), Expect = 1e-12 Identities = 53/178 (29%), Positives = 90/178 (50%), Gaps = 8/178 (4%) Query: 14 QETKQLVAIKIID---KTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVT 70 + T Q+VAIK I +++ + + RE+++++ L HP+II L + I LV Sbjct: 32 KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVF 91 Query: 71 EYASGGEIFDHLVAHGRMAEKEARRKFKQIVT--AVYFCHCRNIVHRDLKAENLLLDANL 128 ++ + ++ + + K ++T + + H I+HRDLK NLLLD N Sbjct: 92 DFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG 149 Query: 129 NIKIADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185 +K+ADFG + F +P + + Y APEL G G VD+W++G +L L+ Sbjct: 150 VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 >gi|13432166|sp|P20794|MAK_HUMAN Serine/threonine-protein kinase MAK (Male germ cell-associated kinase) Length = 623 Score = 72.0 bits (175), Expect = 1e-12 Identities = 70/276 (25%), Positives = 119/276 (43%), Gaps = 19/276 (6%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G ++ E+ +LVAIK + + + + REV+ +K L H ++I+L +V+ Sbjct: 16 GSVLMGKSNESGELVAIKRMKRKFYSWDECMNL-REVKSLKKLNHANVIKLKEVIRENDH 74 Query: 66 IYLVTEYASGGEIFDHLVAHGRM-AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124 +Y + EY ++ + ++ E R QI+ + F H HRD+K ENLL Sbjct: 75 LYFIFEYMKEN-LYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLC 133 Query: 125 DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVVLYV 183 +KIADFG + + + Y APE L Y P +D+W++G ++ Sbjct: 134 MGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP-IDVWAVGSIMAE 192 Query: 184 LVCGALPFDGSTLQN---LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSI------- 233 L F G++ + +VL + + L ++ R C+ I Sbjct: 193 LYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ-CVPINLKTLIP 251 Query: 234 ---AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266 E L+ ML DP KR + Q KH + ++G Sbjct: 252 NASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVG 287 >gi|14548079|sp|Q14164|IKKE_HUMAN Inhibitor of nuclear factor kappa-B kinase epsilon subunit (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK-E) (Inducible I kappa-B kinase) (IKK-i) Length = 716 Score = 72.0 bits (175), Expect = 1e-12 Identities = 53/194 (27%), Positives = 92/194 (47%), Gaps = 17/194 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIYLVTE 71 +++ +LVA+K+ + T ++ RE ++++ L H +I++L+ V ET R LV E Sbjct: 29 KKSGELVAVKVFNTTSYLRPREVQV-REFEVLRKLNHQNIVKLFAVEETGGSRQKVLVME 87 Query: 72 YASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---- 124 Y S G + L + + E E + +V + IVHRD+K N++ Sbjct: 88 YCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGE 147 Query: 125 DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK-------VDIWSL 177 + K+ DFG + + + G+ Y P+++E P+ VD+WS+ Sbjct: 148 EGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSI 207 Query: 178 GVVLYVLVCGALPF 191 GV LY G+LPF Sbjct: 208 GVTLYHAATGSLPF 221 >gi|119554|sp|P28482|MK01_HUMAN Mitogen-activated protein kinase 1 (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) Length = 360 Score = 71.6 bits (174), Expect = 2e-12 Identities = 78/326 (23%), Positives = 139/326 (42%), Gaps = 54/326 (16%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM----- 60 G + + K VAIK I + + ++ RE++I+ H +II + ++ Sbjct: 37 GMVCSAYDNVNKVRVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTI 95 Query: 61 ETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAE 120 E + +Y+V + L+ ++ QI+ + + H N++HRDLK Sbjct: 96 EQMKDVYIVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPS 153 Query: 121 NLLLDANLNIKIADFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176 NLLL+ ++KI DFG + + P L + + Y APE+ + +DIWS Sbjct: 154 NLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 213 Query: 177 LGVVLYVLVCGALPFDG----------------------STLQNLRAR----VLSGKFRI 210 +G +L ++ F G + + NL+AR L K ++ Sbjct: 214 VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKV 273 Query: 211 PFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADP 270 P+ L P D ++ L+ ML +P+KR+ +EQ H +++ DP Sbjct: 274 PW---NRLFPNAD----------SKALDLLDKMLTFNPHKRIEVEQALAHPYLE-QYYDP 319 Query: 271 NFDRLIAECQQLKEERQVDPLNEDVL 296 + D IAE K + ++D L ++ L Sbjct: 320 S-DEPIAEA-PFKFDMELDDLPKEKL 343 >gi|1177044|sp|P43403|ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 (70 kDa zeta-associated protein) (Syk-related tyrosine kinase) Length = 619 Score = 71.2 bits (173), Expect = 2e-12 Identities = 59/194 (30%), Positives = 92/194 (47%), Gaps = 9/194 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK++ K ++ + +++ RE QIM L +P+I+RL V + E ++ LV E A GG + Sbjct: 366 VAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM-LVMEMAGGGPLH 423 Query: 80 DHLVA-HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 LV + Q+ + + +N VHRDL A N+LL KI+DFG S Sbjct: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 Query: 139 NLFTPGQLLKT--WCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193 T G P + APE +++ + D+WS GV ++ L G P+ Sbjct: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-RSDVWSYGVTMWEALSYGQKPYKK 542 Query: 194 STLQNLRARVLSGK 207 + A + GK Sbjct: 543 MKGPEVMAFIEQGK 556 >gi|547915|sp|P36507|MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2) Length = 400 Score = 71.2 bits (173), Expect = 2e-12 Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 13/171 (7%) Query: 37 KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRK 96 +I RE+Q++ P+I+ Y ++ I + E+ GG + D ++ + +E K Sbjct: 114 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKEAKRIPEEILGK 172 Query: 97 FKQIVTA--VYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLL----KTW 150 V Y I+HRD+K N+L+++ IK+ DFG S GQL+ ++ Sbjct: 173 VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSF 227 Query: 151 CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRA 201 G+ Y APE +G Y + DIWS+G+ L L G P + L A Sbjct: 228 VGTRSYMAPERLQGTHY-SVQSDIWSMGLSLVELAVGRYPIPPPDAKELEA 277 >gi|120046|sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase-2) (c-fgr) Length = 822 Score = 71.2 bits (173), Expect = 2e-12 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 23/201 (11%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI 78 VA+K++ K+ E++L + E+++MKM+ H +II L + +Y++ EYAS G + Sbjct: 511 VAVKML-KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569 Query: 79 FDHLVA---------HGRMAEKEARRKFKQIVTAVY-------FCHCRNIVHRDLKAENL 122 ++L A + E + K +V+ Y + + +HRDL A N+ Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629 Query: 123 LLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGV 179 L+ + +KIADFG + ++ KT G P + APE + Y + D+WS GV Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT-HQSDVWSFGV 688 Query: 180 VLY-VLVCGALPFDGSTLQNL 199 +L+ + G P+ G ++ L Sbjct: 689 LLWEIFTLGGSPYPGVPVEEL 709 >gi|1711371|sp|P54764|EPHA4_HUMAN Ephrin type-A receptor 4 precursor (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 71.2 bits (173), Expect = 2e-12 Identities = 56/198 (28%), Positives = 97/198 (48%), Gaps = 9/198 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + D++ + E IM HP+II L V+ + + ++TEY G + Sbjct: 650 VAIKTLKAGYTDKQR-RDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLD 708 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L + GR + + I + + + + VHRDL A N+L+++NL K++DFG S Sbjct: 709 AFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMS 768 Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193 + P T G P + APE +++ D+WS G+V++ V+ G P+ Sbjct: 769 RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSYGERPYWD 827 Query: 194 STLQNLRARVLSGKFRIP 211 + Q++ + G +R+P Sbjct: 828 MSNQDVIKAIEEG-YRLP 844 >gi|6166188|sp|P32298|GRK4_HUMAN G protein-coupled receptor kinase 4 (G protein-coupled receptor kinase GRK4) (ITI1) Length = 578 Score = 71.2 bits (173), Expect = 2e-12 Identities = 49/182 (26%), Positives = 90/182 (49%), Gaps = 4/182 (2%) Query: 13 LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71 ++ T ++ A K + K ++ + + + E +I++ + ++ L ET+ + LV Sbjct: 206 VRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLT 265 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129 +GG++ H+ G E R F ++ + IV+RDLK EN+LLD + Sbjct: 266 IMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGH 325 Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189 I+I+D G + GQ ++ G+ Y APE+ ++Y D W LG ++Y ++ G Sbjct: 326 IRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTF-SPDWWGLGCLIYEMIQGHS 384 Query: 190 PF 191 PF Sbjct: 385 PF 386 >gi|52783106|sp|O95835|LATS1_HUMAN Serine/threonine protein kinase LATS1 (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) Length = 1130 Score = 71.2 bits (173), Expect = 2e-12 Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 50/256 (19%) Query: 15 ETKQLVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 +TK L A K + K + N + + E I+ + ++RLY + + +Y V +Y Sbjct: 726 DTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYI 785 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GG++ L+ G E AR ++ AV H +HRD+K +N+L+D + +IK+ Sbjct: 786 PGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLT 845 Query: 134 DFG--------------------------FSNLFTP------GQLLK------------- 148 DFG FSN + G LK Sbjct: 846 DFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRC 905 Query: 149 ---TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLS 205 + G+P Y APE+ Y D WS+GV+L+ ++ G PF T + +V++ Sbjct: 906 LAHSLVGTPNYIAPEVLLRTGYT-QLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVIN 964 Query: 206 GKFRIPFFMSTGLVPE 221 + + L PE Sbjct: 965 WQTSLHIPPQAKLSPE 980 >gi|2499603|sp|Q15759|MK11_HUMAN Mitogen-activated protein kinase 11 (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress-activated protein kinase-2) Length = 372 Score = 71.2 bits (173), Expect = 2e-12 Identities = 75/335 (22%), Positives = 142/335 (42%), Gaps = 48/335 (14%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQV------ 59 G + + +Q VA+K + + + ++ +RE++++K L H ++I L V Sbjct: 36 GSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATS 95 Query: 60 METERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK--------QIVTAVYFCHCRN 111 +E +YLVT G +++V A + AR Q++ + + H Sbjct: 96 IEDFSEVYLVTTLM--GADLNNIVKCQAGAHQGARLALDEHVQFLVYQLLRGLKYIHSAG 153 Query: 112 IVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK 171 I+HRDLK N+ ++ + ++I DFG + + + + + Y APE+ + Sbjct: 154 IIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQT 211 Query: 172 VDIWSLGVVLYVLVCGALPFDGSTLQNLRARV--------------LSGKFRIPFFMSTG 217 VDIWS+G ++ L+ G F GS + R+ +S + + S Sbjct: 212 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 271 Query: 218 LVPELD-KRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLI 276 +P+ D + G +A L+ MLVLD ++R+S + H + Sbjct: 272 PMPQKDLSSIFRGANPLA--IDLLGRMLVLDSDQRVSAAEALAHAY-------------F 316 Query: 277 AECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQ 311 ++ ++E + +P +E V + KE T Q Sbjct: 317 SQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQ 351 >gi|20455241|sp|Q9Y572|RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) Length = 518 Score = 71.2 bits (173), Expect = 2e-12 Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 21/180 (11%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET-----ERMIYLVTEYAS 74 VA+KI+ N K I REV+ M L + ++RL V+E + LVT++ Sbjct: 47 VAVKIV--------NSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFME 98 Query: 75 GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKI 132 G + L + R K++V +++ H +N ++HRDLK N+L D L++K+ Sbjct: 99 NGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLPDPELHVKL 158 Query: 133 ADFGFSNLFTPGQLLKTWCGSP----PYAAPELFEGKEYDGPKV-DIWSLGVVLYVLVCG 187 ADFG S F G T G P Y APELF D++S G++++ ++ G Sbjct: 159 ADFGLST-FQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAG 217 >gi|17375734|sp|O14976|GAK_HUMAN Cyclin G-associated kinase Length = 1311 Score = 71.2 bits (173), Expect = 2e-12 Identities = 74/259 (28%), Positives = 111/259 (42%), Gaps = 56/259 (21%) Query: 31 DEENLKKIFREVQIMKMLC-HPHIIRLYQVMET--------ERMIYLVTEYASGG--EIF 79 +EE + I +EV MK L HP+I++ + L+TE G E Sbjct: 75 EEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFL 134 Query: 80 DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKIADFGF 137 + + G ++ + F Q AV H + I+HRDLK ENLLL IK+ DFG Sbjct: 135 KKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGS 194 Query: 138 SNLFT--PGQLLKTWCG--------------SPPYAAPELFE--GKEYDGPKVDIWSLGV 179 + + P +W +P Y PE+ + G K DIW+LG Sbjct: 195 ATTISHYPDY---SWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGC 251 Query: 180 VLYVLVCGALPF-DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH 238 +LY+L PF DG+ L R+++GK+ IP + V Sbjct: 252 ILYLLCFRQHPFEDGAKL-----RIVNGKYSIPPHDTQYTV----------------FHS 290 Query: 239 LIRHMLVLDPNKRLSMEQI 257 LIR ML ++P +RLS+ ++ Sbjct: 291 LIRAMLQVNPEERLSIAEV 309 >gi|12644190|sp|P29323|EPHB2_HUMAN Ephrin type-B receptor 2 precursor (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) Length = 1055 Score = 71.2 bits (173), Expect = 2e-12 Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 11/200 (5%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + K+ E+ + E IM HP++I L V+ + ++TE+ G + Sbjct: 650 VAIKTL-KSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLD 708 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L + G+ + + I + + N VHRDL A N+L+++NL K++DFG S Sbjct: 709 SFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLS 768 Query: 139 NLFTPGQLLKTWC----GSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF 191 T+ G P + APE + +++ D+WS G+V++ V+ G P+ Sbjct: 769 RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPY 827 Query: 192 DGSTLQNLRARVLSGKFRIP 211 T Q++ + +R+P Sbjct: 828 WDMTNQDV-INAIEQDYRLP 846 >gi|56405328|sp|P29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 Length = 1187 Score = 70.9 bits (172), Expect = 3e-12 Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 11/177 (6%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYA 73 T ++VA+K + K ++ +E+ I++ L H HII+ E E+ + LV EY Sbjct: 923 TGEMVAVKAL-KADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYV 981 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 G + D+L H + + +QI + + H ++ +HRDL A N+LLD + +KI Sbjct: 982 PLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIG 1040 Query: 134 DFGFSNLFTPGQ---LLKTWCGSPPY-AAPE-LFEGKEYDGPKVDIWSLGVVLYVLV 185 DFG + G ++ SP + APE L E K Y D+WS GV LY L+ Sbjct: 1041 DFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYAS--DVWSFGVTLYELL 1095 Score = 36.6 bits (83), Expect = 0.062 Identities = 61/249 (24%), Positives = 96/249 (38%), Gaps = 32/249 (12%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 V +K++D + D + +M + H H+ ++ V +VTEY G + Sbjct: 639 VVLKVLDPSHHDIA--LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696 Query: 80 DHLV---AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136 L H MA K + Q+ +A+ + +N+VH ++ N+LL A L + Sbjct: 697 VWLRRERGHVPMAWKMVVAQ--QLASALSYLENKNLVHGNVCGRNILL-ARLGLAEGTSP 753 Query: 137 FSNLFTPGQLLKTWCGSP-----PYAAPELFEGKEYD-GPKVDIWSLGVVLYVLVCGALP 190 F L PG L P+ APE G +D W G L + +C Sbjct: 754 FIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATL-LEIC---- 808 Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250 FDG L++R S K F+ +PE C +A L L +P + Sbjct: 809 FDGEA--PLQSRSPSEKEH--FYQRQHRLPE------PSCPQLAT---LTSQCLTYEPTQ 855 Query: 251 RLSMEQICK 259 R S I + Sbjct: 856 RPSFRTILR 864 >gi|2499596|sp|Q16659|MK06_HUMAN Mitogen-activated protein kinase 6 (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) Length = 721 Score = 70.9 bits (172), Expect = 3e-12 Identities = 68/286 (23%), Positives = 125/286 (43%), Gaps = 53/286 (18%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE--------------RM 65 VAIK I T D +++K RE++I++ L H +I+++++++ Sbjct: 46 VAIKKIVLT--DPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNS 103 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125 +Y+V EY +++ G + E+ AR Q++ + + H N++HRDLK NL ++ Sbjct: 104 VYIVQEYMETD--LANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFIN 161 Query: 126 A-NLNIKIADFGFSNLFTPGQ---------LLKTWCGSPPYAAPELFEGKEYDGPKVDIW 175 +L +KI DFG + + P L+ W Y +P L +D+W Sbjct: 162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKW-----YRSPRLLLSPNNYTKAIDMW 216 Query: 176 SLGVVLYVLVCGALPFDGS--------TLQNL-------RARVLSGKFRIPFFMSTGLVP 220 + G + ++ G F G+ L+++ R +LS IP ++ + Sbjct: 217 AAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLS---VIPVYIRNDMT- 272 Query: 221 ELDKRLKAGCLSIA-ECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 265 E K L I+ E + +L P RL+ E+ H +M + Sbjct: 273 EPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSI 318 >gi|2497572|sp|Q15375|EPHA7_HUMAN Ephrin type-A receptor 7 precursor (Tyrosine-protein kinase receptor EHK-3) (Eph homology kinase-3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 70.9 bits (172), Expect = 3e-12 Identities = 54/198 (27%), Positives = 96/198 (48%), Gaps = 9/198 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + K E+ + E IM HP+++ L V+ + + +V E+ G + Sbjct: 662 VAIKTL-KVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALD 720 Query: 80 DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L H G+ + + I + + VHRDL A N+L+++NL K++DFG S Sbjct: 721 AFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLS 780 Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193 + P + T G P + APE + +++ D+WS G+V++ V+ G P+ Sbjct: 781 RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPYWD 839 Query: 194 STLQNLRARVLSGKFRIP 211 + Q++ + G +R+P Sbjct: 840 MSNQDVIKAIEEG-YRLP 856 >gi|6685617|sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 70.5 bits (171), Expect = 4e-12 Identities = 78/311 (25%), Positives = 133/311 (42%), Gaps = 31/311 (9%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 V I I + + D + + E+ + K L H +I++ I + E GG + Sbjct: 704 VRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLS 763 Query: 80 DHLVAH-GRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI-KIADF 135 L + G + + E F KQI+ + + H IVHRD+K +N+L++ + KI+DF Sbjct: 764 ALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDF 823 Query: 136 GFS-NLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 G S L +T+ G+ Y APE+ + G G DIWSLG + + G PF Sbjct: 824 GTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF-- 881 Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253 L +A + F++ F + PE+ + + AE + I DP+KR Sbjct: 882 YELGEPQAAM----FKVGMFK---VHPEIPESMS------AEAKAFILKCFEPDPDKRAC 928 Query: 254 MEQICKHKWMKLGD----ADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ- 308 + +++K+ P L A + + ++ V + +ED E Sbjct: 929 ANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE-----YLRSISLPVPVLVEDTSSSSEYG 983 Query: 309 TLQPDGTLNLD 319 ++ PD L +D Sbjct: 984 SVSPDTELKVD 994 >gi|47117832|sp|P21709|EPHA1_HUMAN Ephrin type-A receptor 1 precursor (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 70.5 bits (171), Expect = 4e-12 Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 7/177 (3%) Query: 40 REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL-VAHGRMAEKEARRKFK 98 RE IM HPHI+ L V+ + I ++TE+ G + L ++ + + Sbjct: 672 REATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQ 731 Query: 99 QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTP-GQLLKTWCGSPP-- 155 I + + + N VHRDL A N+L++ NL K++DFG + L +T G P Sbjct: 732 GIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIR 791 Query: 156 YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRIP 211 + APE + + D+WS G+V++ VL G P+ + Q + + G +R+P Sbjct: 792 WTAPEAIAHRIFTTAS-DVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDG-YRLP 846 >gi|12643404|sp|O60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Janus kinase 2) (JAK-2) Length = 1132 Score = 70.1 bits (170), Expect = 5e-12 Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 23/188 (12%) Query: 11 DFLQE-TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIY 67 D LQ+ T ++VA+K + + EE+L+ RE++I+K L H +I++ V + R + Sbjct: 869 DPLQDNTGEVVAVKKLQHST--EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLK 926 Query: 68 LVTEYASGGEIFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA 126 L+ EY G + D+L H R+ + + QI + + + +HRDL N+L++ Sbjct: 927 LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN 986 Query: 127 NLNIKIADFGFSNLF----------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176 +KI DFG + + PG+ W YA L E K D+WS Sbjct: 987 ENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW-----YAPESLTESK--FSVASDVWS 1039 Query: 177 LGVVLYVL 184 GVVLY L Sbjct: 1040 FGVVLYEL 1047 Score = 48.9 bits (115), Expect = 1e-05 Identities = 44/188 (23%), Positives = 79/188 (42%), Gaps = 14/188 (7%) Query: 9 IQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYL 68 + D+ Q + V +K++DK + + F +M L H H++ Y V L Sbjct: 567 VGDYGQLHETEVLLKVLDKAHRNYS--ESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL 624 Query: 69 VTEYASGGEIFDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLLDAN 127 V E+ G + +L + + + KQ+ A++F ++H ++ A+N+LL Sbjct: 625 VQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIRE 684 Query: 128 LN--------IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV 179 + IK++D G S P +L+ P+ PE E + D WS G Sbjct: 685 EDRKTGNPPFIKLSDPGISITVLPKDILQE---RIPWVPPECIENPKNLNLATDKWSFGT 741 Query: 180 VLYVLVCG 187 L+ + G Sbjct: 742 TLWEICSG 749 >gi|125333|sp|P29317|EPHA2_HUMAN Ephrin type-A receptor 2 precursor (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 70.1 bits (170), Expect = 5e-12 Identities = 57/198 (28%), Positives = 92/198 (46%), Gaps = 9/198 (4%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79 VAIK + K E+ E IM H +IIRL V+ + + ++TEY G + Sbjct: 643 VAIKTL-KAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALD 701 Query: 80 DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138 L G + + + I + + N VHRDL A N+L+++NL K++DFG S Sbjct: 702 KFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLS 761 Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193 + P T G P + APE +++ D+WS G+V++ V+ G P+ Sbjct: 762 RVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSAS-DVWSFGIVMWEVMTYGERPYWE 820 Query: 194 STLQNLRARVLSGKFRIP 211 + + + G FR+P Sbjct: 821 LSNHEVMKAINDG-FRLP 837 >gi|52783149|sp|Q9NRM7|LATS2_HUMAN Serine/threonine protein kinase LATS2 (Large tumor suppressor homolog 2) (Serine/threonine kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase) Length = 1088 Score = 70.1 bits (170), Expect = 5e-12 Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 50/267 (18%) Query: 15 ETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 +T L A+K + K L+ + + E I+ + +++LY + + +Y V +Y Sbjct: 689 DTHALYAMKTLRKKDVLNRNQVVHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYI 748 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 GG++ L+ E AR ++ A+ H +HRD+K +N+L+D + +IK+ Sbjct: 749 PGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLT 808 Query: 134 DFGFSNLF--------------------------------TPGQLLKT------------ 149 DFG F G LKT Sbjct: 809 DFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRC 868 Query: 150 ----WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLS 205 G+P Y APE+ K Y D WS+GV+L+ ++ G PF T + +V++ Sbjct: 869 LAHSLVGTPNYIAPEVLLRKGYT-QLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVIN 927 Query: 206 GKFRIPFFMSTGLVPELDKRLKAGCLS 232 + + L PE + C S Sbjct: 928 WENTLHIPAQVKLSPEARDLITKLCCS 954 >gi|2499660|sp|Q15569|TESK1_HUMAN Dual-specificity testis-specific protein kinase 1 (Testicular protein kinase 1) Length = 626 Score = 69.7 bits (169), Expect = 7e-12 Identities = 49/188 (26%), Positives = 89/188 (47%), Gaps = 10/188 (5%) Query: 6 GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65 G+ + + +Q + ++ +L N REVQ+M L HP+I+R V + Sbjct: 66 GFFSEVYKVRHRQSGQVMVLKMNKLPS-NRGNTLREVQLMNRLRHPNILRFMGVCVHQGQ 124 Query: 66 IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL- 124 ++ +TEY +GG + L + ++ I + + H + + HRDL ++N L+ Sbjct: 125 LHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVR 184 Query: 125 --DANLNIKIADFGFSN---LFTPGQLLKTWC--GSPPYAAPELFEGKEYDGPKVDIWSL 177 D + DFG + ++ G + GSP + APE+ G+ YD K D+++ Sbjct: 185 REDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYD-EKADVFAF 243 Query: 178 GVVLYVLV 185 G+VL L+ Sbjct: 244 GIVLCELI 251 >gi|6831583|sp|O14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) Length = 419 Score = 69.7 bits (169), Expect = 7e-12 Identities = 58/258 (22%), Positives = 110/258 (42%), Gaps = 23/258 (8%) Query: 14 QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73 ++T ++A+K + ++ EEN + + ++K P+I++ + T +++ E Sbjct: 140 RKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM 199 Query: 74 SGGEIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRN-IVHRDLKAENLLLDANLNI 130 G + L G + E+ + IV A+Y+ ++ ++HRD+K N+LLD I Sbjct: 200 --GTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI 257 Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP----KVDIWSLGVVLYVLVC 186 K+ DFG S + G Y APE + + P + D+WSLG+ L L Sbjct: 258 KLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT 317 Query: 187 GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246 G P+ + F + T ++ E L + + ++ L Sbjct: 318 GQFPYKNC--------------KTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTK 363 Query: 247 DPNKRLSMEQICKHKWMK 264 D KR ++ +H ++K Sbjct: 364 DHRKRPKYNKLLEHSFIK 381 >gi|1168867|sp|P11802|CDK4_HUMAN Cell division protein kinase 4 (Cyclin-dependent kinase 4) (PSK-J3) Length = 303 Score = 69.7 bits (169), Expect = 7e-12 Identities = 69/259 (26%), Positives = 112/259 (43%), Gaps = 39/259 (15%) Query: 40 REVQIMKMLC---HPHIIRLYQVMETERM-----IYLVTEYASGG--EIFDHLVAHGRMA 89 REV +++ L HP+++RL V T R + LV E+ D G A Sbjct: 55 REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 Query: 90 EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKT 149 E + +Q + + F H IVHRDLK EN+L+ + +K+ADFG + +++ L Sbjct: 115 ET-IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP 173 Query: 150 WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR 209 + Y APE+ Y P VD+WS+G + + F G++ + ++ Sbjct: 174 VVVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI------ 226 Query: 210 IPFFMSTGLVPE----LDKRLKAGCLS----------IAECE----HLIRHMLVLDPNKR 251 F GL PE D L G + E E L+ ML +P+KR Sbjct: 227 ---FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 Query: 252 LSMEQICKHKWMKLGDADP 270 +S + +H ++ + +P Sbjct: 284 ISAFRALQHSYLHKDEGNP 302 >gi|46577085|sp|Q8WXR4|MYO3B_HUMAN Myosin IIIB Length = 1341 Score = 69.7 bits (169), Expect = 7e-12 Identities = 74/264 (28%), Positives = 119/264 (45%), Gaps = 39/264 (14%) Query: 19 LVAIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETER-----MIYLVTE 71 L A+KI+D + +DEE I E I++ L HP++++ Y + ++LV E Sbjct: 52 LAAVKILDPVSDMDEE----IEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLE 107 Query: 72 YASGGEIFDHLVAHGRMAEKEARRKFKQIV----TAVYFCHCRNIVHRDLKAENLLLDAN 127 +GG + + + R ++ I+ + H I+HRD+K N+LL Sbjct: 108 LCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTE 167 Query: 128 LNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFE-GKEYDG---PKVDIWSLGVVLY 182 +K+ DFG S T +L + T G+P + APE+ ++YD + D+WSLG+ Sbjct: 168 GGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAI 227 Query: 183 VLVCGALP-FDGSTLQNLRARVLSGKFRIPFF-MSTGLVPELDKRLKAGCLSIAECEHLI 240 L G P FD ++ L F+IP T L PE C E H I Sbjct: 228 ELGDGDPPLFDMHPVKTL--------FKIPRNPPPTLLHPE------KWC---EEFNHFI 270 Query: 241 RHMLVLDPNKRLSMEQICKHKWMK 264 L+ D +R S+ + H ++K Sbjct: 271 SQCLIKDFERRPSVTHLLDHPFIK 294 >gi|6685642|sp|O15264|MK13_HUMAN Mitogen-activated protein kinase 13 (Stress-activated protein kinase-4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) Length = 365 Score = 68.9 bits (167), Expect = 1e-11 Identities = 65/271 (23%), Positives = 116/271 (42%), Gaps = 38/271 (14%) Query: 20 VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMI------YLVTEYA 73 VAIK + + E K+ +RE+ ++K + H ++I L V + YLV + Sbjct: 51 VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM 110 Query: 74 SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133 + +E++ + Q++ + + H +VHRDLK NL ++ + +KI Sbjct: 111 QTDL---QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKIL 167 Query: 134 DFGF---SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190 DFG ++ G ++ W Y APE+ + VDIWS+G ++ ++ G Sbjct: 168 DFGLARHADAEMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL 222 Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPEL-DKRLKAGCLSI---------------- 233 F G + ++L ++ T V +L DK K+ S+ Sbjct: 223 FKGKDYLDQLTQIL----KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS 278 Query: 234 AECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264 + L+ ML LD +KRL+ Q H + + Sbjct: 279 PQAADLLEKMLELDVDKRLTAAQALTHPFFE 309 >gi|60393639|sp|Q13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor interacting protein) Length = 671 Score = 68.6 bits (166), Expect = 1e-11 Identities = 51/194 (26%), Positives = 89/194 (45%), Gaps = 15/194 (7%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 T+ L+ +K + K E+ + + E ++M L H +++L V+ E LV EY Sbjct: 38 TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEK 97 Query: 76 GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135 G + L A R +I+ + + H + ++H+DLK EN+L+D + +IKIAD Sbjct: 98 GNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADL 157 Query: 136 GFSNLFTPGQL--------------LKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVV 180 G ++ +L K G+ Y APE L + K D++S VV Sbjct: 158 GLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVV 217 Query: 181 LYVLVCGALPFDGS 194 L+ + P++ + Sbjct: 218 LWAIFANKEPYENA 231 >gi|1708164|sp|P54753|EPHB3_HUMAN Ephrin type-B receptor 3 precursor (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 68.6 bits (166), Expect = 1e-11 Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 13/218 (5%) Query: 2 QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61 +V +G + Q +E VAIK + K E + E IM HP+IIRL V+ Sbjct: 646 EVCRGRLKQPGRREV--FVAIKTL-KVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVT 702 Query: 62 TERMIYLVTEYASGGEIFDHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAE 120 R + ++TE+ + L + G+ + + I + + N VHRDL A Sbjct: 703 KSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAAR 762 Query: 121 NLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS------PPYAAPELFEGKEYDGPKVDI 174 N+L+++NL K++DFG S T+ S + APE +++ D+ Sbjct: 763 NILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSAS-DV 821 Query: 175 WSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRIP 211 WS G+V++ V+ G P+ + Q++ + +R+P Sbjct: 822 WSYGIVMWEVMSYGERPYWDMSNQDV-INAVEQDYRLP 858 >gi|24211444|sp|Q96Q40|AL2S7_HUMAN Serine/threonine-protein kinase ALS2CR7 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) Length = 384 Score = 68.6 bits (166), Expect = 1e-11 Identities = 48/178 (26%), Positives = 86/178 (48%), Gaps = 4/178 (2%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77 QLVA+K+I + I RE ++K L H +I+ L+ ++ T+ + V EY + Sbjct: 76 QLVALKVISMNAEEGVPFTAI-REASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHT-D 133 Query: 78 IFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136 + ++ H G + R Q++ + + H ++++HRDLK +NLL+ +K+ADFG Sbjct: 134 LAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFG 193 Query: 137 FSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193 + + P Q + + Y P+ G ++DIW G + + G F G Sbjct: 194 LARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPG 251 >gi|1174527|sp|P43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Spleen tyrosine kinase) Length = 635 Score = 68.6 bits (166), Expect = 1e-11 Identities = 57/212 (26%), Positives = 95/212 (44%), Gaps = 14/212 (6%) Query: 3 VVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET 62 V KGY +++ + VA+KI+ D ++ E +M+ L +P+I+R+ + E Sbjct: 385 VKKGYYQ---MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEA 441 Query: 63 ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENL 122 E + LV E A G + +L + + +K Q+ + + N VHRDL A N+ Sbjct: 442 ESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNV 500 Query: 123 LLDANLNIKIADFGFSNL------FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176 LL KI+DFG S + Q W + APE ++ K D+WS Sbjct: 501 LLVTQHYAKISDFGLSKALRADENYYKAQTHGKW--PVKWYAPECINYYKFSS-KSDVWS 557 Query: 177 LGVVLY-VLVCGALPFDGSTLQNLRARVLSGK 207 GV+++ G P+ G + A + G+ Sbjct: 558 FGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 >gi|50403745|sp|P52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) Length = 1124 Score = 68.2 bits (165), Expect = 2e-11 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 22/182 (12%) Query: 16 TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYA 73 T LVA+K + + D++ + RE+QI+K L I++ V + + LV EY Sbjct: 848 TGALVAVKQLQHSGPDQQ--RDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYL 905 Query: 74 SGGEIFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132 G + D L H R+ QI + + R VHRDL A N+L+++ ++KI Sbjct: 906 PSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKI 965 Query: 133 ADFGFSNLF----------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182 ADFG + L PGQ W +P + +F + D+WS GVVLY Sbjct: 966 ADFGLAKLLPLDKDYYVVREPGQSPIFWY-APESLSDNIFSRQS------DVWSFGVVLY 1018 Query: 183 VL 184 L Sbjct: 1019 EL 1020 Score = 30.4 bits (67), Expect = 4.5 Identities = 38/179 (21%), Positives = 74/179 (41%), Gaps = 15/179 (8%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREV-QIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75 K V +K++D +N + F E +M + + H++ L+ V +V E+ Sbjct: 550 KTEVLLKVMDAKH---KNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDST-MVQEFVHL 605 Query: 76 GEIFDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLL------DANL 128 G I +L G + + + KQ+ A+ + + + H ++ A +LL + Sbjct: 606 GAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPP 665 Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187 IK++D G S ++L P+ APE + + D W G ++ + G Sbjct: 666 FIKLSDPGVSPAVLSLEMLTDRI---PWVAPECLREAQTLSLEADKWGFGATVWEVFSG 721 >gi|1170596|sp|P45985|MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) Length = 399 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/186 (28%), Positives = 87/186 (46%), Gaps = 16/186 (8%) Query: 18 QLVAIKIIDKTQLDEENLKKIFREVQI-MKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 Q++A+K I T +DE+ K++ ++ + M+ P+I++ Y + E ++ E S Sbjct: 126 QIMAVKRIRST-VDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS 184 Query: 77 EIFDHLVAH-----GRMAEKEARRKFKQIVTAVYFCHCRN---IVHRDLKAENLLLDANL 128 FD + + +E K + T H + I+HRD+K N+LLD + Sbjct: 185 --FDKFYKYVYSVLDDVIPEEILGKIT-LATVKALNHLKENLKIIHRDIKPSNILLDRSG 241 Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLV 185 NIK+ DFG S G PY APE + ++ + D+WSLG+ LY L Sbjct: 242 NIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA 301 Query: 186 CGALPF 191 G P+ Sbjct: 302 TGRFPY 307 >gi|1345718|sp|P49336|CDK8_HUMAN Cell division protein kinase 8 (Protein kinase K35) Length = 464 Score = 68.2 bits (165), Expect = 2e-11 Identities = 72/292 (24%), Positives = 120/292 (41%), Gaps = 57/292 (19%) Query: 40 REVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYASGGEIFDHLVAHGRMAEKE----- 92 RE+ +++ L HP++I L +V +R ++L+ +YA H++ R ++ Sbjct: 65 REIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHD--LWHIIKFHRASKANKKPVQ 122 Query: 93 -----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTP 143 + QI+ +++ H ++HRDLK N+L+ +KIAD GF+ LF Sbjct: 123 LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF-- 180 Query: 144 GQLLKTWCGSPP------YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF-----D 192 LK P Y APEL G + +DIW++G + L+ F D Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240 Query: 193 GSTLQNLRARVLSGKFRIPFFMS-------------TGLVPELDKRLKAGCLSIAECE-- 237 T L F + F + + L+ + + C I E Sbjct: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 300 Query: 238 ---------HLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQ 280 HL++ +L +DP KR++ EQ + + L D P D + A CQ Sbjct: 301 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF-LEDPLPTSD-VFAGCQ 350 >gi|60391917|sp|Q9BWU1|CD2L6_HUMAN Cell division cycle 2-like protein kinase 6 (CDC2-related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11) Length = 502 Score = 68.2 bits (165), Expect = 2e-11 Identities = 74/310 (23%), Positives = 132/310 (42%), Gaps = 67/310 (21%) Query: 40 REVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYASGGEIFDHLVAHGRMAEKE----- 92 RE+ +++ L HP++I L +V ++R ++L+ +YA H++ R ++ Sbjct: 65 REIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHD--LWHIIKFHRASKANKKPMQ 122 Query: 93 -----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTP 143 + QI+ +++ H ++HRDLK N+L+ +KIAD GF+ LF Sbjct: 123 LPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF-- 180 Query: 144 GQLLKTWCGSPP------YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG---------- 187 LK P Y APEL G + +DIW++G + L+ Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240 Query: 188 ---ALPFDGSTLQNL-------------------RARVLSGKFRIPFFMSTGLVPELDK- 224 + PF L + L FR + ++ L+ ++K Sbjct: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH 300 Query: 225 RLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE 284 ++K ++ L++ +L +DP KR++ EQ + + + D P D + A CQ Sbjct: 301 KVKPD----SKVFLLLQKLLTMDPTKRITSEQALQDPYFQ-EDPLPTLD-VFAGCQIPYP 354 Query: 285 ERQVDPLNED 294 +R+ LNED Sbjct: 355 KREF--LNED 362 >gi|549081|sp|P35590|TIE1_HUMAN Tyrosine-protein kinase receptor Tie-1 precursor Length = 1138 Score = 67.8 bits (164), Expect = 3e-11 Identities = 65/229 (28%), Positives = 100/229 (43%), Gaps = 35/229 (15%) Query: 2 QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVM 60 QV++ I +D L K AIK++ K E + + E++++ K+ HP+II L Sbjct: 852 QVIRAMIKKDGL---KMNAAIKML-KEYASENDHRDFAGELEVLCKLGHHPNIINLLGAC 907 Query: 61 ETERMIYLVTEYASGGEIFDHLVA-------------HGRMAEKEARRKFK---QIVTAV 104 + +Y+ EYA G + D L HG + +R+ + + Sbjct: 908 KNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGM 967 Query: 105 YFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN------LFTPGQLLKTWCGSPPYAA 158 + + +HRDL A N+L+ NL KIADFG S T G+L W A Sbjct: 968 QYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRW------MA 1021 Query: 159 PELFEGKEYDGPKVDIWSLGVVLYVLV-CGALPFDGSTLQNLRARVLSG 206 E Y K D+WS GV+L+ +V G P+ G T L ++ G Sbjct: 1022 IESLNYSVYT-TKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 1069 >gi|32172458|sp|Q9BQI3|E2K1_HUMAN Eukaryotic translation initiation factor 2 alpha kinase 1 (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor-2 alpha kinase) (PRO1362) Length = 630 Score = 67.4 bits (163), Expect = 3e-11 Identities = 75/264 (28%), Positives = 124/264 (46%), Gaps = 45/264 (17%) Query: 58 QVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDL 117 Q+ E ++V G E D MA A + F+++V V++ H IVHRDL Sbjct: 385 QLCELSLWDWIVERNKRGREYVDESACPYVMANV-ATKIFQELVEGVFYIHNMGIVHRDL 443 Query: 118 KAENLLLDA-NLNIKIADFGF---------------SNLFTPGQLLKTWCGSPPYAAPEL 161 K N+ L + +KI DFG + TP + G+ YA+PE Sbjct: 444 KPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRV--GTCLYASPEQ 501 Query: 162 FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPE 221 EG EYD K D++SLGVVL L PF G+ ++ RA VL+G + TG +PE Sbjct: 502 LEGSEYDA-KSDMYSLGVVLLELF---QPF-GTEME--RAEVLTG-------LRTGQLPE 547 Query: 222 LDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHK-WMKLGDADPNFDRLIAECQ 280 L+ C A+ I+H+ + ++R S Q+ + + + G+ + L + + Sbjct: 548 ---SLRKRCPVQAK---YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVN-----LTLQMK 596 Query: 281 QLKEERQVDPLNEDVLLAMEDMGL 304 +++E+++ L + + L +D G+ Sbjct: 597 IIEQEKEIAELKKQLNLLSQDKGV 620 >gi|266423|sp|Q00534|CDK6_HUMAN Cell division protein kinase 6 (Serine/threonine-protein kinase PLSTIRE) Length = 326 Score = 67.4 bits (163), Expect = 3e-11 Identities = 53/179 (29%), Positives = 90/179 (50%), Gaps = 14/179 (7%) Query: 13 LQETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLC---HPHIIRLYQVM-----ETE 63 L+ + VA+K + + Q EE + REV +++ L HP+++RL+ V + E Sbjct: 33 LKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRE 91 Query: 64 RMIYLVTEYASGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121 + LV E+ D + G E F Q++ + F H +VHRDLK +N Sbjct: 92 TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF-QLLRGLDFLHSHRVVHRDLKPQN 150 Query: 122 LLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV 180 +L+ ++ IK+ADFG + +++ L + + Y APE+ Y P VD+WS+G + Sbjct: 151 ILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGCI 208 >gi|2497562|sp|Q16288|NTRK3_HUMAN NT-3 growth factor receptor precursor (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C) Length = 839 Score = 67.4 bits (163), Expect = 3e-11 Identities = 57/199 (28%), Positives = 87/199 (43%), Gaps = 36/199 (18%) Query: 17 KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76 K LVA+K + L K RE +++ L H HI++ Y V + +V EY G Sbjct: 566 KMLVAVKALKDPTLAAR--KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623 Query: 77 EIFDHLVAHGRMA-------EKEARRKF---------KQIVTAVYFCHCRNIVHRDLKAE 120 ++ L AHG A ++A+ + QI + + + ++ VHRDL Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATR 683 Query: 121 NLLLDANLNIKIADFGFS---------NLFTP-GQLLKTWCGSPPYA-------APELFE 163 N L+ ANL +KI DFG S LF P G WC + PE Sbjct: 684 NCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM 743 Query: 164 GKEYDGPKVDIWSLGVVLY 182 +++ + D+WS GV+L+ Sbjct: 744 YRKFT-TESDVWSFGVILW 761 Database: Non-redundant SwissProt sequences Posted date: Mar 15, 2005 10:11 AM Number of letters in database: 60,490,055 Number of sequences in database: 164,271 Lambda K H 0.316 0.132 0.392 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,941,679 Number of Sequences: 164271 Number of extensions: 145878 Number of successful extensions: 747 Number of sequences better than 10.0: 64 Number of HSP's better than 10.0 without gapping: 37 Number of HSP's successfully gapped in prelim test: 27 Number of HSP's that attempted gapping in prelim test: 531 Number of HSP's gapped (non-prelim): 167 length of query: 1347 length of database: 6,424,444 effective HSP length: 107 effective length of query: 1240 effective length of database: 5,150,609 effective search space: 6386755160 effective search space used: 6386755160 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 64 (29.3 bits)