RID=1111134056-29364-76162250300.BLASTQ2, FGENESH: 6 26 exon (s) 249419

BLASTP 2.2.10 [Oct-19-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.
RID: 1111134056-29364-76162250300.BLASTQ2
Query= FGENESH: 6 26 exon (s) 249419 - 372401 1347 aa, chain - (1347 letters)
Database: Non-redundant SwissProt sequences 164,271 sequences; 60,490,055 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Taxonomy reports
Distribution of 576 Blast Hits on the Query Sequence


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|113992|sp|P02647|APOA1_HUMAN  Apolipoprotein A-I precurso...   475   e-134 
gi|59798973|sp|Q9H0K1|SN1L2_HUMAN  Serine/threonine-protein ...   363   e-100 
gi|59803093|sp|P57059|SN1L1_HUMAN  Serine/threonine-protein ...   330   2e-90 
gi|29840797|sp|Q96L34|MARK4_HUMAN  MAP/microtubule affinity-...   325   5e-89 
gi|29337165|sp|P27448|MARK3_HUMAN  MAP/microtubule affinity-...   315   9e-86 
gi|34395849|sp|Q8IWQ3|BRSK2_HUMAN  BR serine/threonine-prote...   244   2e-64 
gi|34395684|sp|Q8TDC3|KI11_HUMAN  Probable serine/threonine-...   243   4e-64 
gi|20178276|sp|P54646|AAPK2_HUMAN  5'-AMP-activated protein ...   238   8e-63 
gi|20178277|sp|Q13131|AAPK1_HUMAN  5'-AMP-activated protein ...   238   1e-62 
gi|14424095|sp|O60285|ARK5_HUMAN  AMPK-related protein kinase 5   224   2e-58 
gi|50400857|sp|Q14680|MELK_HUMAN  Maternal embryonic leucine...   195   8e-50 
gi|30316282|sp|Q9BXA7|ST22A_HUMAN  Serine/threonine-protein ...   186   6e-47 
gi|30316269|sp|Q96PF2|ST22B_HUMAN  Serine/threonine-protein ...   168   1e-41 
gi|9973393|sp|P57058|HUNK_HUMAN  Hormonally up-regulated neu...   166   4e-41 
gi|30316270|sp|Q96PN8|ST22C_HUMAN  Serine/threonine-protein ...   164   2e-40 
gi|27805738|sp|Q9UQB9|AURKC_HUMAN  Serine/threonine-protein ...   162   6e-40 
gi|2499586|sp|Q16566|KCC4_HUMAN  Calcium/calmodulin-dependen...   160   4e-39 
gi|3122301|sp|Q14012|KCC1A_HUMAN  Calcium/calmodulin-depende...   156   4e-38 
gi|56404610|sp|Q8IU85|KCC1D_HUMAN  Calcium/calmodulin-depend...   150   2e-36 
gi|27923855|sp|O14965|STK6_HUMAN  Serine/threonine-protein k...   149   5e-36 
gi|27805737|sp|Q96GD4|AURKB_HUMAN  Serine/threonine-protein ...   148   1e-35 
gi|125536|sp|P15735|PHKG2_HUMAN  Phosphorylase b kinase gamm...   146   6e-35 
gi|6685284|sp|O96017|CHK2_HUMAN  Serine/threonine-protein ki...   145   1e-34 
gi|17379144|sp|P11801|KPSH1_HUMAN  Serine/threonine-protein ...   143   5e-34 
gi|2833281|sp|Q16816|PHKG1_HUMAN  Phosphorylase b kinase gam...   142   6e-34 
gi|38605718|sp|P53355|DAPK1_HUMAN  Death-associated protein ...   142   6e-34 
gi|20177970|sp|Q9UQM7|KCC2A_HUMAN  Calcium/calmodulin-depend...   141   2e-33 
gi|56404655|sp|Q96NX5|KCC1G_HUMAN  Calcium/calmodulin-depend...   140   2e-33 
gi|7531055|sp|O14757|CHK1_HUMAN  Serine/threonine-protein ki...   140   4e-33 
gi|12643414|sp|Q13557|KCC2D_HUMAN  Calcium/calmodulin-depend...   139   5e-33 
gi|51316189|sp|O00444|PLK4_HUMAN  Serine/threonine-protein k...   139   5e-33 
gi|38604691|sp|O43293|DAPK3_HUMAN  Death-associated protein ...   139   9e-33 
gi|12643413|sp|Q13554|KCC2B_HUMAN  Calcium/calmodulin-depend...   139   9e-33 
gi|20178304|sp|Q13555|KCC2G_HUMAN  Calcium/calmodulin-depend...   138   1e-32 
gi|37999482|sp|O75582|KS6A5_HUMAN  Ribosomal protein S6 kina...   136   4e-32 
gi|6136124|sp|O75385|ULK1_HUMAN  Serine/threonine-protein ki...   136   4e-32 
gi|6225242|sp|O15075|DCAK1_HUMAN  Serine/threonine-protein k...   135   1e-31 
gi|1170703|sp|P31751|AKT2_HUMAN  RAC-beta serine/threonine-p...   133   4e-31 
gi|125210|sp|P22694|KAPCB_HUMAN  cAMP-dependent protein kina...   132   1e-30 
gi|38605084|sp|Q9UIK4|DAPK2_HUMAN  Death-associated protein ...   131   1e-30 
gi|11133131|sp|Q9UK32|KS6A6_HUMAN  Ribosomal protein S6 kina...   131   2e-30 
gi|59797954|sp|Q8N568|DCAK2_HUMAN  Serine/threonine-protein ...   131   2e-30 
gi|12643943|sp|Q9Y243|AKT3_HUMAN  RAC-gamma serine/threonine...   130   2e-30 
gi|14423930|sp|Q9UEE5|ST17A_HUMAN  Serine/threonine-protein ...   130   2e-30 
gi|1709648|sp|P51817|PRKX_HUMAN  Serine/threonine-protein ki...   130   4e-30 
gi|1346538|sp|P49137|MAPK2_HUMAN  MAP kinase-activated prote...   129   5e-30 
gi|33860173|sp|P22612|KAPCG_HUMAN  cAMP-dependent protein ki...   129   5e-30 
gi|125205|sp|P17612|KAPCA_HUMAN  cAMP-dependent protein kina...   128   1e-29 
gi|20141585|sp|Q05513|KPCZ_HUMAN  Protein kinase C, zeta typ...   127   2e-29 
gi|37999483|sp|O75676|KS6A4_HUMAN  Ribosomal protein S6 kina...   126   5e-29 
gi|60391226|sp|P31749|AKT1_HUMAN  RAC-alpha serine/threonine...   126   6e-29 
gi|27735175|sp|O14936|CSKP_HUMAN  Peripheral plasma membrane...   126   6e-29 
gi|6226833|sp|Q13237|KGP2_HUMAN  cGMP-dependent protein kina...   124   2e-28 
gi|1730070|sp|P51812|KS6A3_HUMAN  Ribosomal protein S6 kinas...   124   2e-28 
gi|51338822|sp|Q9H4B4|PLK3_HUMAN  Serine/threonine-protein k...   123   4e-28 
gi|1170688|sp|P41743|KPCI_HUMAN  Protein kinase C, iota type...   123   5e-28 
gi|41017453|sp|O43930|PRKY_HUMAN  Serine/threonine-protein k...   122   7e-28 
gi|20178306|sp|Q15418|KS6A1_HUMAN  Ribosomal protein S6 kina...   122   7e-28 
gi|22096374|sp|Q9NYY3|PLK2_HUMAN  Serine/threonine-protein k...   122   9e-28 
gi|6166243|sp|Q15349|KS6A2_HUMAN  Ribosomal protein S6 kinas...   121   2e-27 
gi|1346393|sp|P24723|KPCL_HUMAN  Protein kinase C, eta type ...   120   3e-27 
gi|41017502|sp|Q96RG2|PASK_HUMAN  PAS domain containing seri...   120   3e-27 
gi|34098463|sp|Q86SG6|NEK8_HUMAN  Serine/threonine-protein k...   119   1e-26 
gi|1709658|sp|P53350|PLK1_HUMAN  Serine/threonine-protein ki...   117   2e-26 
gi|56404656|sp|Q96RR4|KKCC2_HUMAN  Calcium/calmodulin-depend...   117   2e-26 
gi|125549|sp|P17252|KPCA_HUMAN  Protein kinase C, alpha type...   117   3e-26 
gi|400135|sp|Q02156|KPCE_HUMAN  Protein kinase C, epsilon ty...   116   6e-26 
gi|3024670|sp|Q15831|STK11_HUMAN  Serine/threonine-protein k...   116   6e-26 
gi|462455|sp|P05129|KPCG_HUMAN  Protein kinase C, gamma type...   115   1e-25 
gi|56404620|sp|Q8N5S9|KKCC1_HUMAN  Calcium/calmodulin-depend...   115   1e-25 
gi|2499575|sp|Q15139|KPCM_HUMAN  Protein kinase C, mu type (...   115   1e-25 
gi|28558166|sp|Q9HBY8|SGK2_HUMAN  Serine/threonine-protein k...   114   2e-25 
gi|125379|sp|P14619|KGP1B_HUMAN  cGMP-dependent protein kina...   114   2e-25 
gi|6225588|sp|Q13976|KGP1A_HUMAN  cGMP-dependent protein kin...   114   2e-25 
gi|20138711|sp|Q9BZL6|KPCD2_HUMAN  Protein kinase C, D2 type...   113   5e-25 
gi|20141488|sp|P05771|KPCB_HUMAN  Protein kinase C, beta typ...   113   5e-25 
gi|17380162|sp|O15530|PDPK1_HUMAN  3-phosphoinositide depend...   112   9e-25 
gi|52000829|sp|Q8IW41|MAPK5_HUMAN  MAP kinase-activated prot...   112   1e-24 
gi|24211884|sp|Q9H1R3|MYLK2_HUMAN  Myosin light chain kinase...   111   2e-24 
gi|12230239|sp|O94806|KPCN_HUMAN  Protein kinase C, nu type ...   110   3e-24 
gi|3041712|sp|Q13177|PAK2_HUMAN  Serine/threonine-protein ki...   110   3e-24 
gi|1709252|sp|P51955|NEK2_HUMAN  Serine/threonine-protein ki...   109   6e-24 
gi|2499643|sp|Q13153|PAK1_HUMAN  Serine/threonine-protein ki...   109   6e-24 
gi|12644418|sp|Q15746|MYLK_HUMAN  Myosin light chain kinase,...   109   6e-24 
gi|20141582|sp|Q04759|KPCT_HUMAN  Protein kinase C, theta ty...   109   8e-24 
gi|60390226|sp|Q9Y2H9|MAST1_HUMAN  Microtubule-associated se...   109   8e-24 
gi|22256934|sp|Q96PY6|NEK1_HUMAN  Serine/threonine-protein k...   108   1e-23 
gi|3914977|sp|O00141|SGK1_HUMAN  Serine/threonine-protein ki...   108   1e-23 
gi|56405369|sp|Q00532|KKIA_HUMAN  Serine/threonine-protein k...   108   1e-23 
gi|6225859|sp|Q16513|PKL2_HUMAN  Protein kinase N2 (Protein ...   108   1e-23 
gi|38502964|sp|Q86V86|PIM3_HUMAN  Serine/threonine-protein k...   107   2e-23 
gi|54041234|sp|P23443|KS6B1_HUMAN  Ribosomal protein S6 kina...   107   3e-23 
gi|14423909|sp|O94768|ST17B_HUMAN  Serine/threonine-protein ...   107   4e-23 
gi|12643872|sp|Q9UBS0|KS6B2_HUMAN  Ribosomal protein S6 kina...   107   4e-23 
gi|125565|sp|P11309|PIM1_HUMAN  Proto-oncogene serine/threon...   106   5e-23 
gi|47117818|sp|O75914|PAK3_HUMAN  Serine/threonine-protein k...   106   6e-23 
gi|8928460|sp|O75962|TRIO_HUMAN  Triple functional domain pr...   105   1e-22 
gi|20139243|sp|Q9P1W9|PIM2_HUMAN  Serine/threonine-protein k...   104   2e-22 
gi|28558163|sp|Q96BR1|SGK3_HUMAN  Serine/threonine-protein k...   104   2e-22 
gi|47605999|sp|Q13464|ROCK1_HUMAN  Rho-associated protein ki...   103   4e-22 
gi|13626607|sp|Q9Y6E0|STK24_HUMAN  Serine/threonine-protein ...   102   9e-22 
gi|12643529|sp|O00506|STK25_HUMAN  Serine/threonine-protein ...   102   9e-22 
gi|6174910|sp|Q16512|PKL1_HUMAN  Protein kinase N1 (Protein ...   102   9e-22 
gi|547803|sp|Q05655|KPCD_HUMAN  Protein kinase C, delta type...   102   9e-22 
gi|30316125|sp|Q9HBH9|MKNK2_HUMAN  MAP kinase-interacting se...   102   1e-21 
gi|12585288|sp|O96013|PAK4_HUMAN  Serine/threonine-protein k...   100   3e-21 
gi|231726|sp|Q00526|CDK3_HUMAN  Cell division protein kinase 3    100   5e-21 
gi|20178297|sp|P51956|NEK3_HUMAN  Serine/threonine-protein k...    99   8e-21 
gi|12585290|sp|Q9P286|PAK7_HUMAN  Serine/threonine-protein k...    98   2e-20 
gi|6175070|sp|O76039|CDKL5_HUMAN  Serine/threonine-protein k...    97   4e-20 
gi|1705489|sp|P51813|BMX_HUMAN  Cytoplasmic tyrosine-protein...    97   5e-20 
gi|47605963|sp|O75116|ROCK2_HUMAN  Rho-associated protein ki...    97   5e-20 
gi|34098605|sp|Q8TD19|NEK9_HUMAN  Serine/threonine-protein k...    95   1e-19 
gi|2499640|sp|Q99759|M3K3_HUMAN  Mitogen-activated protein k...    95   1e-19 
gi|4033704|sp|Q00535|CDK5_HUMAN  Cell division protein kinas...    95   2e-19 
gi|115922|sp|P06493|CDC2_HUMAN  Cell division control protei...    95   2e-19 
gi|6685620|sp|Q9Y2U5|M3K2_HUMAN  Mitogen-activated protein k...    95   2e-19 
gi|6685621|sp|Q9Y6R4|M3K4_HUMAN  Mitogen-activated protein k...    94   3e-19 
gi|12643825|sp|Q9NYV4|CD2L7_HUMAN  Cell division cycle 2-rel...    94   3e-19 
gi|3915762|sp|P53667|LIK1_HUMAN  LIM domain kinase 1 (LIMK-1)      94   4e-19 
gi|116051|sp|P24941|CDK2_HUMAN  Cell division protein kinase...    93   6e-19 
gi|1709347|sp|P51957|NEK4_HUMAN  Serine/threonine-protein ki...    93   6e-19 
gi|23396789|sp|Q9NQU5|PAK6_HUMAN  Serine/threonine-protein k...    92   1e-18 
gi|46577700|sp|Q13188|STK3_HUMAN  Serine/threonine-protein k...    91   3e-18 
gi|56749668|sp|Q9Y2H1|ST38L_HUMAN  Serine/threonine-protein ...    91   3e-18 
gi|13124559|sp|Q13043|STK4_HUMAN  Serine/threonine-protein k...    91   3e-18 
gi|2833269|sp|Q15835|RK_HUMAN  Rhodopsin kinase (RK) (G prot...    91   4e-18 
gi|12643880|sp|Q9UEW8|STK39_HUMAN  STE20/SPS1-related prolin...    90   6e-18 
gi|1708824|sp|P53671|LIK2_HUMAN  LIM domain kinase 2 (LIMK-2)      89   1e-17 
gi|57015279|sp|O14578|CTRO_HUMAN  Citron Rho-interacting kin...    89   1e-17 
gi|10719935|sp|Q14004|CD2L5_HUMAN  Cell division cycle 2-lik...    89   1e-17 
gi|30316115|sp|Q9BUB5|MKNK1_HUMAN  MAP kinase-interacting se...    87   3e-17 
gi|46396051|sp|Q9Y2A5|DUET_HUMAN  Serine/threonine-protein k...    87   4e-17 
gi|1170598|sp|P45984|MK09_HUMAN  Mitogen-activated protein k...    87   5e-17 
gi|14285497|sp|O14920|IKKB_HUMAN  Inhibitor of nuclear facto...    87   5e-17 
gi|8488988|sp|Q13233|M3K1_HUMAN  Mitogen-activated protein k...    86   7e-17 
gi|125480|sp|P07948|LYN_HUMAN  Tyrosine-protein kinase Lyn         86   7e-17 
gi|12643358|sp|O94804|STK10_HUMAN  Serine/threonine-protein ...    86   7e-17 
gi|20178302|sp|Q07002|PCTK3_HUMAN  Serine/threonine-protein ...    86   1e-16 
gi|34222826|sp|Q86UE8|TLK2_HUMAN  Serine/threonine-protein k...    86   1e-16 
gi|114006|sp|P06727|APOA4_HUMAN  Apolipoprotein A-IV precurs...    86   1e-16 
gi|56749457|sp|Q15208|STK38_HUMAN  Serine/threonine-protein ...    85   2e-16 
gi|462203|sp|P34947|GRK5_HUMAN  G protein-coupled receptor k...    85   2e-16 
gi|1706450|sp|Q09013|DMPK_HUMAN  Myotonin-protein kinase (My...    85   2e-16 
gi|14285498|sp|O15111|IKKA_HUMAN  Inhibitor of nuclear facto...    84   3e-16 
gi|59803097|sp|Q00537|PCTK2_HUMAN  Serine/threonine-protein ...    84   3e-16 
gi|20141386|sp|P43250|GRK6_HUMAN  G protein-coupled receptor...    84   3e-16 
gi|125351|sp|P16591|FER_HUMAN  Proto-oncogene tyrosine-prote...    84   3e-16 
gi|1169745|sp|P42685|FRK_HUMAN  Tyrosine-protein kinase FRK ...    84   3e-16 
gi|266425|sp|Q00536|PCTK1_HUMAN  Serine/threonine-protein ki...    83   6e-16 
gi|125474|sp|P06239|LCK_HUMAN  Proto-oncogene tyrosine-prote...    83   6e-16 
gi|34223086|sp|Q9UKI8|TLK1_HUMAN  Serine/threonine-protein k...    82   1e-15 
gi|464971|sp|P33981|TTK_HUMAN  Dual specificity protein kina...    82   1e-15 
gi|19857975|sp|P29322|EPHA8_HUMAN  Ephrin type-A receptor 8 ...    82   1e-15 
gi|8928302|sp|Q13882|PTK6_HUMAN  Tyrosine-protein kinase 6 (...    82   1e-15 
gi|41688789|sp|Q96J92|WNK4_HUMAN  Serine/threonine-protein k...    82   1e-15 
gi|125135|sp|P00519|ABL1_HUMAN  Proto-oncogene tyrosine-prot...    82   2e-15 
gi|1351326|sp|P42681|TXK_HUMAN  Tyrosine-protein kinase TXK        82   2e-15 
gi|2507195|sp|P45983|MK08_HUMAN  Mitogen-activated protein k...    81   2e-15 
gi|29427817|sp|Q8IVH8|M4K3_HUMAN  Mitogen-activated protein ...    81   2e-15 
gi|1730068|sp|P10398|ARAF_HUMAN  A-Raf proto-oncogene serine...    81   3e-15 
gi|2507196|sp|P53779|MK10_HUMAN  Mitogen-activated protein k...    81   3e-15 
gi|1168268|sp|P42684|ABL2_HUMAN  Tyrosine-protein kinase ABL...    80   4e-15 
gi|41688795|sp|Q9H4A3|WNK1_HUMAN  Serine/threonine-protein k...    80   4e-15 
gi|27805732|sp|Q9H3Y6|SRMS_HUMAN  Tyrosine-protein kinase Srms     80   4e-15 
gi|125651|sp|P04049|RAF1_HUMAN  RAF proto-oncogene serine/th...    80   5e-15 
gi|50403720|sp|P15056|BRAF1_HUMAN  B-Raf proto-oncogene seri...    80   5e-15 
gi|12643557|sp|O43318|M3K7_HUMAN  Mitogen-activated protein ...    80   5e-15 
gi|41688792|sp|Q9BYP7|WNK3_HUMAN  Serine/threonine-protein k...    80   5e-15 
gi|50400798|sp|Q9UBE8|NLK_HUMAN  Serine/threonine kinase NLK...    80   6e-15 
gi|2851522|sp|P53778|MK12_HUMAN  Mitogen-activated protein k...    80   6e-15 
gi|12644292|sp|P49840|GSK3A_HUMAN  Glycogen synthase kinase-...    80   6e-15 
gi|125711|sp|P12931|SRC_HUMAN  Proto-oncogene tyrosine-prote...    80   6e-15 
gi|37537965|sp|Q8TDX7|NEK7_HUMAN  Serine/threonine-protein k...    80   6e-15 
gi|2499600|sp|Q16539|MK14_HUMAN  Mitogen-activated protein k...    79   8e-15 
gi|29840818|sp|Q9UKE5|TNIK_HUMAN  TRAF2 and NCK interacting ...    79   8e-15 
gi|41688799|sp|Q9Y3S1|WNK2_HUMAN  Serine/threonine-protein k...    79   8e-15 
gi|29427834|sp|Q8N4C8|M4K6_HUMAN  Mitogen-activated protein ...    79   1e-14 
gi|400274|sp|Q02750|MP2K1_HUMAN  Dual specificity mitogen-ac...    78   2e-14 
gi|20141296|sp|P08631|HCK_HUMAN  Tyrosine-protein kinase HCK...    78   2e-14 
gi|125370|sp|P06241|FYN_HUMAN  Proto-oncogene tyrosine-prote...    77   3e-14 
gi|45593475|sp|Q12851|M4K2_HUMAN  Mitogen-activated protein ...    77   3e-14 
gi|543848|sp|P35626|ARBK2_HUMAN  Beta-adrenergic receptor ki...    77   3e-14 
gi|1174630|sp|P42680|TEC_HUMAN  Tyrosine-protein kinase Tec        77   3e-14 
gi|37537993|sp|Q9HC98|NEK6_HUMAN  Serine/threonine-protein k...    77   4e-14 
gi|585361|sp|Q08881|ITK_HUMAN  Tyrosine-protein kinase ITK/T...    77   4e-14 
gi|22653927|sp|O94921|PFTK1_HUMAN  Serine/threonine-protein ...    77   5e-14 
gi|1705485|sp|P51451|BLK_HUMAN  Tyrosine-protein kinase BLK ...    77   5e-14 
gi|28201830|sp|Q96RU7|TRIB3_HUMAN  Tribbles homolog 3 (TRB-3...    76   7e-14 
gi|547759|sp|Q06187|BTK_HUMAN  Tyrosine-protein kinase BTK (...    76   7e-14 
gi|29427585|sp|O95819|M4K4_HUMAN  Mitogen-activated protein ...    76   7e-14 
gi|2499633|sp|Q13163|MP2K5_HUMAN  Dual specificity mitogen-a...    76   9e-14 
gi|125870|sp|P07947|YES_HUMAN  Proto-oncogene tyrosine-prote...    76   9e-14 
gi|30316147|sp|Q9Y4K4|M4K5_HUMAN  Mitogen-activated protein ...    76   9e-14 
gi|114152|sp|P25098|ARBK1_HUMAN  Beta-adrenergic receptor ki...    75   1e-13 
gi|125387|sp|P29320|EPHA3_HUMAN  Ephrin type-A receptor 3 pr...    75   1e-13 
gi|3183518|sp|Q05397|FAK1_HUMAN  Focal adhesion kinase 1 (FA...    75   1e-13 
gi|400127|sp|P07332|FES_HUMAN  Proto-oncogene tyrosine-prote...    75   1e-13 
gi|21263659|sp|Q8WTQ7|GRK7_HUMAN  G protein-coupled receptor...    75   1e-13 
gi|399448|sp|P31152|MK04_HUMAN  Mitogen-activated protein ki...    75   2e-13 
gi|729887|sp|P41240|CSK_HUMAN  Tyrosine-protein kinase CSK (...    74   3e-13 
gi|20141243|sp|P50750|CDK9_HUMAN  Cell division protein kina...    74   3e-13 
gi|1706628|sp|P54756|EPHA5_HUMAN  Ephrin type-A receptor 5 p...    74   3e-13 
gi|46577075|sp|Q8NEV4|MYO3A_HUMAN  Myosin IIIA                     74   4e-13 
gi|18202489|sp|Q12852|M3K12_HUMAN  Mitogen-activated protein...    74   4e-13 
gi|20455502|sp|P49841|GSK3B_HUMAN  Glycogen synthase kinase-...    74   5e-13 
gi|48428273|sp|Q9UPZ9|ICK_HUMAN  Serine/threonine kinase ICK...    73   6e-13 
gi|125358|sp|P09769|FGR_HUMAN  Proto-oncogene tyrosine-prote...    73   6e-13 
gi|120049|sp|P21802|FGFR2_HUMAN  Fibroblast growth factor re...    73   8e-13 
gi|232066|sp|P27361|MK03_HUMAN  Mitogen-activated protein ki...    72   1e-12 
gi|1706663|sp|P54762|EPHB1_HUMAN  Ephrin type-B receptor 1 p...    72   1e-12 
gi|1705722|sp|P50613|CDK7_HUMAN  Cell division protein kinas...    72   1e-12 
gi|13432166|sp|P20794|MAK_HUMAN  Serine/threonine-protein ki...    72   1e-12 
gi|14548079|sp|Q14164|IKKE_HUMAN  Inhibitor of nuclear facto...    72   1e-12 
gi|119554|sp|P28482|MK01_HUMAN  Mitogen-activated protein ki...    72   2e-12 
gi|1177044|sp|P43403|ZAP70_HUMAN  Tyrosine-protein kinase ZA...    71   2e-12 
gi|547915|sp|P36507|MP2K2_HUMAN  Dual specificity mitogen-ac...    71   2e-12 
gi|120046|sp|P11362|FGFR1_HUMAN  Basic fibroblast growth fac...    71   2e-12 
gi|1711371|sp|P54764|EPHA4_HUMAN  Ephrin type-A receptor 4 p...    71   2e-12 
gi|6166188|sp|P32298|GRK4_HUMAN  G protein-coupled receptor ...    71   2e-12 
gi|52783106|sp|O95835|LATS1_HUMAN  Serine/threonine protein ...    71   2e-12 
gi|2499603|sp|Q15759|MK11_HUMAN  Mitogen-activated protein k...    71   2e-12 
gi|20455241|sp|Q9Y572|RIPK3_HUMAN  Receptor-interacting seri...    71   2e-12 
gi|17375734|sp|O14976|GAK_HUMAN  Cyclin G-associated kinase        71   2e-12 
gi|12644190|sp|P29323|EPHB2_HUMAN  Ephrin type-B receptor 2 ...    71   2e-12 
gi|56405328|sp|P29597|TYK2_HUMAN  Non-receptor tyrosine-prot...    71   3e-12 
gi|2499596|sp|Q16659|MK06_HUMAN  Mitogen-activated protein k...    71   3e-12 
gi|2497572|sp|Q15375|EPHA7_HUMAN  Ephrin type-A receptor 7 p...    71   3e-12 
gi|6685617|sp|Q99683|M3K5_HUMAN  Mitogen-activated protein k...    70   4e-12 
gi|47117832|sp|P21709|EPHA1_HUMAN  Ephrin type-A receptor 1 ...    70   4e-12 
gi|12643404|sp|O60674|JAK2_HUMAN  Tyrosine-protein kinase JA...    70   5e-12 
gi|125333|sp|P29317|EPHA2_HUMAN  Ephrin type-A receptor 2 pr...    70   5e-12 
gi|52783149|sp|Q9NRM7|LATS2_HUMAN  Serine/threonine protein ...    70   5e-12 
gi|2499660|sp|Q15569|TESK1_HUMAN  Dual-specificity testis-sp...    70   7e-12 
gi|6831583|sp|O14733|MP2K7_HUMAN  Dual specificity mitogen-a...    70   7e-12 
gi|1168867|sp|P11802|CDK4_HUMAN  Cell division protein kinas...    70   7e-12 
gi|46577085|sp|Q8WXR4|MYO3B_HUMAN  Myosin IIIB                     70   7e-12 
gi|6685642|sp|O15264|MK13_HUMAN  Mitogen-activated protein k...    69   1e-11 
gi|60393639|sp|Q13546|RIPK1_HUMAN  Receptor-interacting seri...    69   1e-11 
gi|1708164|sp|P54753|EPHB3_HUMAN  Ephrin type-B receptor 3 p...    69   1e-11 
gi|24211444|sp|Q96Q40|AL2S7_HUMAN  Serine/threonine-protein ...    69   1e-11 
gi|1174527|sp|P43405|KSYK_HUMAN  Tyrosine-protein kinase SYK...    69   1e-11 
gi|50403745|sp|P52333|JAK3_HUMAN  Tyrosine-protein kinase JA...    68   2e-11 
gi|1170596|sp|P45985|MP2K4_HUMAN  Dual specificity mitogen-a...    68   2e-11 
gi|1345718|sp|P49336|CDK8_HUMAN  Cell division protein kinas...    68   2e-11 
gi|60391917|sp|Q9BWU1|CD2L6_HUMAN  Cell division cycle 2-lik...    68   2e-11 
gi|549081|sp|P35590|TIE1_HUMAN  Tyrosine-protein kinase rece...    68   3e-11 
gi|32172458|sp|Q9BQI3|E2K1_HUMAN  Eukaryotic translation ini...    67   3e-11 
gi|266423|sp|Q00534|CDK6_HUMAN  Cell division protein kinase...    67   3e-11 
gi|2497562|sp|Q16288|NTRK3_HUMAN  NT-3 growth factor recepto...    67   3e-11 
gi|6685614|sp|O95382|M3K6_HUMAN  Mitogen-activated protein k...    67   3e-11 
gi|119534|sp|P21860|ERBB3_HUMAN  Receptor tyrosine-protein k...    67   4e-11 
gi|19860819|sp|P54760|EPHB4_HUMAN  Ephrin type-B receptor 4 ...    67   6e-11 
gi|25009462|sp|Q96S53|TESK2_HUMAN  Dual specificity testis-s...    67   6e-11 
gi|2497560|sp|Q16620|NTRK2_HUMAN  BDNF/NT-3 growth factors r...    67   6e-11 
gi|23831382|sp|Q13523|PRP4B_HUMAN  Serine/threonine-protein ...    67   6e-11 
gi|50401181|sp|Q9NWZ3|IRAK4_HUMAN  Interleukin-1 receptor-as...    66   7e-11 
gi|462606|sp|P80192|M3K9_HUMAN  Mitogen-activated protein ki...    66   7e-11 
gi|55976573|sp|Q99640|PMYT1_HUMAN  Membrane-associated tyros...    66   7e-11 
gi|120050|sp|P22607|FGFR3_HUMAN  Fibroblast growth factor re...    66   7e-11 
gi|55977123|sp|P68400|CSK21_HUMAN  Casein kinase II, alpha c...    66   7e-11 
gi|34922255|sp|Q9UQ88|CD2L2_HUMAN  PITSLRE serine/threonine-...    66   7e-11 
gi|27923858|sp|Q8TDR2|STK35_HUMAN  Serine/threonine-protein ...    65   1e-10 
gi|2499599|sp|Q13164|MK07_HUMAN  Mitogen-activated protein k...    65   1e-10 
gi|3913590|sp|Q15303|ERBB4_HUMAN  Receptor tyrosine-protein ...    65   2e-10 
gi|50403742|sp|P41279|M3K8_HUMAN  Mitogen-activated protein ...    65   2e-10 
gi|41017258|sp|Q9UQ07|MOK_HUMAN  MAPK/MAK/MRK overlapping ki...    65   2e-10 
gi|13432140|sp|P22455|FGFR4_HUMAN  Fibroblast growth factor ...    65   2e-10 
gi|34978359|sp|P21127|CD2L1_HUMAN  PITSLRE serine/threonine-...    65   2e-10 
gi|6226784|sp|Q15131|CDK10_HUMAN  Cell division protein kina...    64   3e-10 
gi|1709088|sp|P52564|MP2K6_HUMAN  Dual specificity mitogen-a...    64   3e-10 
gi|13878706|sp|Q01974|ROR2_HUMAN  Tyrosine-protein kinase tr...    64   4e-10 
gi|119533|sp|P04626|ERBB2_HUMAN  Receptor tyrosine-protein k...    64   4e-10 
gi|547807|sp|P07949|RET_HUMAN  Proto-oncogene tyrosine-prote...    64   5e-10 
gi|1169123|sp|P42679|MATK_HUMAN  Megakaryocyte-associated ty...    64   5e-10 
gi|729008|sp|Q08345|DDR1_HUMAN  Epithelial discoidin domain ...    64   5e-10 
gi|29427916|sp|Q92918|M4K1_HUMAN  Mitogen-activated protein ...    64   5e-10 
gi|60391728|sp|Q6Q788|APOA5_HUMAN  Apolipoprotein A-V precur...    63   8e-10 
gi|37999491|sp|Q07912|ACK1_HUMAN  Activated CDC42 kinase 1 (...    63   8e-10 
gi|2497564|sp|Q16832|DDR2_HUMAN  Discoidin domain receptor 2...    62   1e-09 
gi|1717829|sp|Q06418|TYRO3_HUMAN  Tyrosine-protein kinase re...    62   1e-09 
gi|14285588|sp|Q99558|M3K14_HUMAN  Mitogen-activated protein...    61   2e-09 
gi|2811086|sp|P00533|EGFR_HUMAN  Epidermal growth factor rec...    61   3e-09 
gi|125266|sp|P19784|CSK22_HUMAN  Casein kinase II, alpha' ch...    61   3e-09 
gi|2851601|sp|P04629|NTRK1_HUMAN  High affinity nerve growth...    61   3e-09 
gi|9296963|sp|Q9Y463|DYR1B_HUMAN  Dual-specificity tyrosine-...    60   4e-09 
gi|125060|sp|P23458|JAK1_HUMAN  Tyrosine-protein kinase JAK1...    60   5e-09 
gi|464868|sp|Q02763|TIE2_HUMAN  Angiopoietin 1 receptor prec...    60   7e-09 
gi|51315812|sp|O75460|ERN1_HUMAN  Serine/threonine protein k...    60   7e-09 
gi|59896668|sp|Q13470|TNK1_HUMAN  Non-receptor tyrosine-prot...    60   7e-09 
gi|12644000|sp|P14616|INSRR_HUMAN  Insulin receptor-related ...    59   9e-09 
gi|19924290|sp|Q01973|ROR1_HUMAN  Tyrosine-protein kinase tr...    59   1e-08 
gi|10719883|sp|P57078|RIPK4_HUMAN  Serine/threonine-protein ...    59   2e-08 
gi|3183003|sp|Q14289|FAK2_HUMAN  Protein tyrosine kinase 2 b...    58   2e-08 
gi|33112647|sp|P06213|INSR_HUMAN  Insulin receptor precursor...    58   2e-08 
gi|34222653|sp|Q9NSY1|BMP2K_HUMAN  BMP-2 inducible protein k...    58   3e-08 
gi|125527|sp|P19525|E2AK2_HUMAN  Interferon-induced, double-...    57   4e-08 
gi|20455217|sp|O43353|RIPK2_HUMAN  Receptor-interacting seri...    57   6e-08 
gi|6686295|sp|Q02779|M3K10_HUMAN  Mitogen-activated protein ...    55   2e-07 
gi|125497|sp|P00540|MOS_HUMAN  Proto-oncogene serine/threoni...    55   2e-07 
gi|56749062|sp|Q6VAB6|KSR2_HUMAN  Kinase suppressor of ras-2...    54   3e-07 
gi|125484|sp|P08581|MET_HUMAN  Hepatocyte growth factor rece...    54   3e-07 
gi|18203329|sp|Q9NZJ5|E2AK3_HUMAN  Eukaryotic translation in...    54   3e-07 
gi|48429194|sp|P30530|UFO_HUMAN  Tyrosine-protein kinase rec...    54   4e-07 
gi|13626405|sp|Q9NR20|DYRK4_HUMAN  Dual-specificity tyrosine...    54   4e-07 
gi|20532386|sp|Q13705|AVR2B_HUMAN  Activin receptor type IIB...    54   4e-07 
gi|24638466|sp|P46734|MP2K3_HUMAN  Dual specificity mitogen-...    54   5e-07 
gi|13626369|sp|O43781|DYRK3_HUMAN  Dual-specificity tyrosine...    54   5e-07 
gi|3219996|sp|Q13627|DYR1A_HUMAN  Dual-specificity tyrosine-...    53   6e-07 
gi|124240|sp|P08069|IGF1R_HUMAN  Insulin-like growth factor ...    53   6e-07 
gi|46577677|sp|O75716|STK16_HUMAN  Serine/threonine-protein ...    53   6e-07 
gi|6919882|sp|O15197|EPHB6_HUMAN  Ephrin type-B receptor 6 p...    53   8e-07 
gi|8134650|sp|Q13308|PTK7_HUMAN  Tyrosine-protein kinase-lik...    53   8e-07 
gi|56749095|sp|Q8IVT5|KSR1_HUMAN  Kinase suppressor of ras-1...    53   8e-07 
gi|13626380|sp|Q92630|DYRK2_HUMAN  Dual-specificity tyrosine...    52   1e-06 
gi|34395641|sp|Q86Z02|HIPK1_HUMAN  Homeodomain-interacting p...    52   1e-06 
gi|585912|sp|Q04912|RON_HUMAN  Macrophage-stimulating protei...    52   2e-06 
gi|50400806|sp|O15146|MUSK_HUMAN  Muscle, skeletal receptor ...    52   2e-06 
gi|114722|sp|P27037|ACVR2_HUMAN  Activin receptor type II pr...    51   3e-06 
gi|125361|sp|P17948|VGFR1_HUMAN  Vascular endothelial growth...    51   3e-06 
gi|21431782|sp|Q9H2X6|HIPK2_HUMAN  Homeodomain-interacting p...    51   3e-06 
gi|547778|sp|P36894|BMR1A_HUMAN  Bone morphogenetic protein ...    50   5e-06 
gi|1351419|sp|P30291|WEE1_HUMAN  Wee1-like protein kinase (W...    50   7e-06 
gi|1718189|sp|P35916|VGFR3_HUMAN  Vascular endothelial growt...    50   7e-06 
gi|10720097|sp|Q12866|MERTK_HUMAN  Proto-oncogene tyrosine-p...    49   9e-06 
gi|9087218|sp|P35968|VGFR2_HUMAN  Vascular endothelial growt...    49   1e-05 
gi|2506798|sp|P08922|ROS_HUMAN  Proto-oncogene tyrosine-prot...    49   1e-05 
gi|1706243|sp|P51841|GUC2F_HUMAN  Retinal guanylyl cyclase 2...    49   2e-05 
gi|544320|sp|P36888|FLT3_HUMAN  FL cytokine receptor precurs...    49   2e-05 
gi|51315898|sp|Q76MJ5|ERN2_HUMAN  Serine/threonine protein k...    48   3e-05 
gi|20137251|sp|Q9UM73|ALK_HUMAN  ALK tyrosine kinase recepto...    47   6e-05 
gi|125472|sp|P10721|KIT_HUMAN  Mast/stem cell growth factor ...    46   8e-05 
gi|1705918|sp|P49759|CLK1_HUMAN  Dual specificity protein ki...    46   8e-05 
gi|113916|sp|P20594|ANPB_HUMAN  Atrial natriuretic peptide r...    46   8e-05 
gi|114039|sp|P02649|APOE_HUMAN  Apolipoprotein E precursor (...    45   1e-04 
gi|462447|sp|Q04771|ACVR1_HUMAN  Activin receptor type I pre...    45   1e-04 
gi|586086|sp|P37173|TGFR2_HUMAN  TGF-beta receptor type II p...    45   1e-04 
gi|12230224|sp|O43187|IRA2_HUMAN  Interleukin-1 receptor-ass...    45   2e-04 
gi|24211880|sp|Q8TAS1|UHMK1_HUMAN  Serine/threonine-protein ...    45   2e-04 
gi|113912|sp|P16066|ANPA_HUMAN  Atrial natriuretic peptide r...    45   2e-04 
gi|3915750|sp|P37023|ACVL1_HUMAN  Serine/threonine-protein k...    45   2e-04 
gi|1170674|sp|P29376|LTK_HUMAN  Leukocyte tyrosine kinase re...    44   4e-04 
gi|1345920|sp|Q02846|GUC2D_HUMAN  Retinal guanylyl cyclase 1...    44   5e-04 
gi|129892|sp|P16234|PGFRA_HUMAN  Alpha platelet-derived grow...    44   5e-04 
gi|1346369|sp|P49674|KC1E_HUMAN  Casein kinase I, epsilon is...    44   5e-04 
gi|27923980|sp|P48730|KC1D_HUMAN  Casein kinase I, delta iso...    44   5e-04 
gi|18202957|sp|Q9HCP0|KC1G1_HUMAN  Casein kinase I, gamma 1 ...    43   7e-04 
gi|47117932|sp|Q9Y6M4|KC1G3_HUMAN  Casein kinase I, gamma 3 ...    43   7e-04 
gi|34922132|sp|Q9HAZ1|CLK4_HUMAN  Dual specificity protein k...    43   9e-04 
gi|129890|sp|P09619|PGFRB_HUMAN  Beta platelet-derived growt...    42   0.001 
gi|55584013|sp|Q9Y616|IRAK3_HUMAN  Interleukin-1 receptor-as...    42   0.001 
gi|6226778|sp|O00238|BMR1B_HUMAN  Bone morphogenetic protein...    42   0.001 
gi|1705919|sp|P49760|CLK2_HUMAN  Dual specificity protein ki...    42   0.002 
gi|547775|sp|P36896|ACV1B_HUMAN  Serine/threonine-protein ki...    41   0.003 
gi|3024060|sp|P78368|KC1G2_HUMAN  Casein kinase I, gamma 2 i...    40   0.004 
gi|1169540|sp|P42566|EP15_HUMAN  Epidermal growth factor rec...    40   0.004 
gi|123682|sp|P25092|HSER_HUMAN  Heat-stable enterotoxin rece...    40   0.004 
gi|20141240|sp|P49761|CLK3_HUMAN  Dual specificity protein k...    40   0.004 
gi|34222508|sp|Q15075|EEA1_HUMAN  Early endosome antigen 1 (...    40   0.007 
gi|547777|sp|P36897|TGFR1_HUMAN  TGF-beta receptor type I pr...    40   0.007 
gi|547770|sp|P07333|CSF1R_HUMAN  Macrophage colony stimulati...    39   0.010 
gi|12643724|sp|Q13873|BMPR2_HUMAN  Bone morphogenetic protei...    39   0.013 
gi|59800398|sp|Q96KB5|TOPK_HUMAN  T-lymphokine-activated kil...    39   0.013 
gi|23822112|sp|Q9P2E9|RRB1_HUMAN  Ribosome-binding protein 1...    39   0.016 
gi|21264536|sp|P45379|TNNT2_HUMAN  Troponin T, cardiac muscl...    39   0.016 
gi|47115790|sp|Q8BK63|KC1A_MOUSE  Casein kinase I, alpha iso...    38   0.021 
gi|9973397|sp|Q13418|ILK1_HUMAN  Integrin-linked protein kin...    38   0.021 
gi|9973390|sp|P57043|ILK2_HUMAN  Integrin-linked protein kin...    38   0.028 
gi|20178343|sp|Q14141|SEPT6_HUMAN  Septin 6                        37   0.036 
gi|547966|sp|P12883|MYH7_HUMAN  Myosin heavy chain, cardiac ...    37   0.036 
gi|417216|sp|P33176|KINH_HUMAN  Kinesin heavy chain (Ubiquit...    37   0.062 
gi|8928535|sp|P51617|IRAK1_HUMAN  Interleukin-1 receptor-ass...    36   0.081 
gi|14194461|sp|Q99996|AKAP9_HUMAN  A-kinase anchor protein 9...    36   0.081 
gi|1710811|sp|P34925|RYK_HUMAN  Tyrosine-protein kinase RYK ...    36   0.081 
gi|1709851|sp|P23246|SFPQ_HUMAN  Splicing factor, proline-an...    36   0.11  
gi|17375490|sp|Q14203|DYNA_HUMAN  Dynactin 1 (150 kDa dynein...    36   0.11  
gi|33518637|sp|P45378|TNNT3_HUMAN  Troponin T, fast skeletal...    36   0.11  
gi|1346640|sp|P35580|MYH10_HUMAN  Myosin heavy chain, nonmus...    35   0.14  
gi|1174800|sp|P13805|TNNT1_HUMAN  Troponin T, slow skeletal ...    35   0.14  
gi|8134814|sp|Q9UPW0|FOXJ3_HUMAN  Forkhead box protein J3          35   0.14  
gi|33301318|sp|Q92614|MY18A_HUMAN  Myosin XVIIIA (Myosin 18A...    35   0.18  
gi|20455324|sp|Q9H2D6|TARA_HUMAN  TRIO and F-actin binding p...    35   0.18  
gi|586120|sp|Q07283|TRHY_HUMAN  Trichohyalin                       35   0.18  
gi|45593722|sp|Q86Y07|VRK2_HUMAN  Serine/threonine-protein k...    35   0.18  
gi|47115840|sp|Q8N752|KC1AL_HUMAN  Casein kinase I, alpha-li...    35   0.18  
gi|1346343|sp|P04264|K2C1_HUMAN  Keratin, type II cytoskelet...    35   0.18  
gi|50403702|sp|O95613|PCNT2_HUMAN  Pericentrin 2 (Pericentri...    35   0.18  
gi|48428484|sp|Q9BXM7|PINK1_HUMAN  Serine/threonine kinase P...    35   0.24  
gi|30580351|sp|Q8NHQ8|CL02_HUMAN  Protein C12orf2 (Carcinoma...    35   0.24  
gi|12643957|sp|Q9Y618|NCOR2_HUMAN  Nuclear receptor corepres...    35   0.24  
gi|21759000|sp|Q12955|ANK3_HUMAN  Ankyrin 3 (ANK-3) (Ankyrin G)    34   0.31  
gi|2493434|sp|Q01082|SPCO_HUMAN  Spectrin beta chain, brain ...    34   0.31  
gi|41688595|sp|Q9UJC3|HOOK1_HUMAN  Hook homolog 1 (h-hook1) ...    34   0.40  
gi|25009466|sp|Q9UIF3|TEK2_HUMAN  Tektin-2 (Testicular tekti...    34   0.40  
gi|32469766|sp|Q92805|GOA1_HUMAN  Golgi autoantigen, golgin ...    34   0.40  
gi|23831094|sp|O00291|HIP1_HUMAN  Huntingtin interacting pro...    34   0.40  
gi|118685|sp|P11532|DMD_HUMAN  Dystrophin                          34   0.40  
gi|17372543|sp|Q12934|BFS1_HUMAN  Filensin (Beaded filament ...    33   0.53  
gi|1730008|sp|P53804|TTC3_HUMAN  Tetratricopeptide repeat pr...    33   0.53  
gi|417031|sp|P32455|GBP1_HUMAN  Interferon-induced guanylate...    33   0.53  
gi|30912698|sp|Q8NB25|CF60_HUMAN  Hypothetical protein C6orf60     33   0.53  
gi|47606000|sp|Q15276|RAP1_HUMAN  Rab GTPase binding effecto...    33   0.69  
gi|12643718|sp|Q13439|GOA4_HUMAN  Golgi autoantigen, golgin ...    33   0.69  
gi|14195007|sp|Q15149|PLE1_HUMAN  Plectin 1 (PLTN) (PCN) (He...    33   0.69  
gi|50401687|sp|Q9NVA2|SEP11_HUMAN  Septin 11                       33   0.90  
gi|28201804|sp|Q14789|GOGB1_HUMAN  Golgi autoantigen, golgin...    33   0.90  
gi|12643528|sp|O00311|CDC7_HUMAN  Cell division cycle 7-rela...    33   0.90  
gi|56405385|sp|Q9HCM9|TM39_HUMAN  Tripartite motif protein 3...    33   0.90  
gi|547754|sp|P35908|K22E_HUMAN  Keratin, type II cytoskeleta...    33   0.90  
gi|28201884|sp|P78424|PO6F2_HUMAN  POU domain, class 6, tran...    33   0.90  
gi|3041707|sp|P13535|MYH8_HUMAN  Myosin heavy chain, skeleta...    32   1.2   
gi|20138952|sp|Q15025|NAF1_HUMAN  Nef-associated factor 1 (N...    32   1.2   
gi|266902|sp|P30622|REST_HUMAN  Restin (Cytoplasmic linker p...    32   1.2   
gi|133326|sp|P24928|RPB1_HUMAN  DNA-directed RNA polymerase ...    32   1.2   
gi|14548191|sp|O15162|PLS1_HUMAN  Phospholipid scramblase 1 ...    32   1.2   
gi|1709078|sp|P50221|MEOX1_HUMAN  Homeobox protein MOX-1 (Me...    32   1.2   
gi|1346682|sp|P48681|NEST_HUMAN  Nestin                            32   1.2   
gi|20532393|sp|O15230|LMA5_HUMAN  Laminin alpha-5 chain prec...    32   1.2   
gi|29337005|sp|Q9UQE7|SMC3_HUMAN  Structural maintenance of ...    32   1.5   
gi|23503070|sp|Q06547|GABP2_HUMAN  GA binding protein beta c...    32   1.5   
gi|56405387|sp|Q9UPN3|MACF1_HUMAN  Microtubule-actin crossli...    32   1.5   
gi|44887869|sp|Q96EP5|DAZP1_HUMAN  DAZ-associated protein 1 ...    32   1.5   
gi|30316105|sp|Q96PK2|MAC4_HUMAN  Microtubule-actin crosslin...    32   1.5   
gi|41688571|sp|Q13477|MACA_HUMAN  Mucosal addressin cell adh...    32   1.5   
gi|48474671|sp|Q9NSB2|K2H4_HUMAN  Keratin, type II cuticular...    32   1.5   
gi|6136547|sp|O60299|Y552_HUMAN  Hypothetical protein KIAA0552     32   2.0   
gi|23396633|sp|Q15058|KF14_HUMAN  Kinesin-like protein KIF14       32   2.0   
gi|32470610|sp|Q08378|GOA3_HUMAN  Golgi autoantigen, golgin ...    32   2.0   
gi|1350802|sp|Q05823|RN5A_HUMAN  2-5A-dependent ribonuclease...    32   2.0   
gi|29429203|sp|P54259|DRPLA_HUMAN  Atrophin-1 (Dentatorubral...    32   2.0   
gi|60392986|sp|Q92878|RAD50_HUMAN  DNA repair protein RAD50 ...    31   2.6   
gi|132518|sp|P22670|RFX1_HUMAN  MHC class II regulatory fact...    31   2.6   
gi|2495730|sp|Q92558|WAS1_HUMAN  Wiskott-Aldrich syndrome pr...    31   2.6   
gi|59800455|sp|Q9UPY6|WASF3_HUMAN  Wiskott-Aldrich syndrome ...    31   2.6   
gi|2506877|sp|Q02817|MUC2_HUMAN  Mucin 2 precursor (Intestin...    31   2.6   
gi|26392452|sp|Q9BQ89|CT55_HUMAN  Protein C20orf55                 31   2.6   
gi|2498313|sp|Q16643|DREB_HUMAN  Drebrin (Developmentally re...    31   2.6   
gi|3913957|sp|O14782|KF3C_HUMAN  Kinesin-like protein KIF3C        31   2.6   
gi|52000729|sp|Q8WWM7|ATXL_HUMAN  Ataxin-2-like protein (Ata...    31   2.6   
gi|17367904|sp|O15020|SPCP_HUMAN  Spectrin beta chain, brain...    31   2.6   
gi|32129445|sp|Q96SN8|C5P2_HUMAN  CDK5 regulatory subunit as...    31   2.6   
gi|13124568|sp|Q9UPE1|STK23_HUMAN  Serine/threonine-protein ...    31   3.4   
gi|25008939|sp|O75626|PRDM1_HUMAN  PR-domain zinc finger pro...    31   3.4   
gi|9087133|sp|Q16671|AMHR2_HUMAN  Anti-Muellerian hormone ty...    31   3.4   
gi|17373489|sp|Q13111|CAF1A_HUMAN  Chromatin assembly factor...    31   3.4   
gi|54035738|sp|Q9Y2D8|ADIP_HUMAN  Afadin- and alpha-actinin-...    31   3.4   
gi|400793|sp|Q00722|PIB2_HUMAN  1-phosphatidylinositol-4,5-b...    31   3.4   
gi|55976299|sp|Q14134|TM29_HUMAN  Tripartite motif protein 2...    31   3.4   
gi|1709217|sp|P49792|RBP2_HUMAN  Ran-binding protein 2 (RanB...    31   3.4   
gi|42558969|sp|Q13136|LPA1_HUMAN  Liprin-alpha 1 (Protein ty...    31   3.4   
gi|14194715|sp|Q92817|EVPL_HUMAN  Envoplakin (210 kDa parane...    31   3.4   
gi|50401165|sp|Q9H3R2|MU13_HUMAN  Mucin 13 precursor (Down-r...    31   3.4   
gi|32469788|sp|Q9NYA3|GOA6_HUMAN  Golgi autoantigen, golgin ...    31   3.4   
gi|12643326|sp|Q9ULV3|CIZ1_HUMAN  Cip1-interacting zinc fing...    31   3.4   
gi|22653665|sp|Q9NRL2|BAZ1A_HUMAN  Bromodomain adjacent to z...    31   3.4   
gi|13959694|sp|O95239|KF4A_HUMAN  Chromosome-associated kine...    31   3.4   
gi|29839588|sp|Q8WXH0|SNE2_HUMAN  Nesprin 2 (Nuclear envelop...    31   3.4   
gi|12643319|sp|O75665|OFD1_HUMAN  Oral-facial-digital syndro...    30   4.5   
gi|34098413|sp|Q15311|RBP1_HUMAN  RalA binding protein 1 (Ra...    30   4.5   
gi|1345731|sp|P49454|CENPF_HUMAN  CENP-F kinetochore protein...    30   4.5   
gi|45593726|sp|Q99986|VRK1_HUMAN  Serine/threonine-protein k...    30   4.5   
gi|544357|sp|P35637|FUS_HUMAN  RNA-binding protein FUS (Onco...    30   4.5   
gi|51701377|sp|O15083|ERC2_HUMAN  ERC protein 2                    30   4.5   
gi|3023440|sp|Q92793|CBP_HUMAN  CREB-binding protein               30   4.5   
gi|13432177|sp|P35749|MYH11_HUMAN  Myosin heavy chain, smoot...    30   4.5   
gi|6166599|sp|P35579|MYH9_HUMAN  Myosin heavy chain, nonmusc...    30   4.5   
gi|17366354|sp|P58397|ATS12_HUMAN  ADAMTS-12 precursor (A di...    30   4.5   
gi|51827892|sp|Q8IUD2|ERC1_HUMAN  ERC protein 1 (ELKS protein)     30   4.5   
gi|20454925|sp|Q96RT7|GCP6_HUMAN  Gamma-tubulin complex comp...    30   4.5   
gi|33112673|sp|Q9Y496|KF3A_HUMAN  Kinesin-like protein KIF3A...    30   4.5   
gi|25452905|sp|Q9H501|CT06_HUMAN  Hypothetical protein C20orf6     30   5.8   
gi|731165|sp|Q02040|XE7_HUMAN  B-lymphocyte antigen precurso...    30   5.8   
gi|2498204|sp|Q05682|CALD1_HUMAN  Caldesmon (CDM)                  30   5.8   
gi|18202959|sp|Q9HCU9|BRMS1_HUMAN  Breast cancer metastasis-...    30   5.8   
gi|14916998|sp|P00390|GSHR_HUMAN  Glutathione reductase, mit...    30   5.8   
gi|1169868|sp|P32456|GBP2_HUMAN  Interferon-induced guanylat...    30   5.8   
gi|30580364|sp|Q9BV73|CEP2_HUMAN  Centrosomal protein 2 (Cen...    30   5.8   
gi|23503097|sp|P57071|PRD15_HUMAN  PR-domain zinc finger pro...    30   5.8   
gi|134798|sp|P11277|SPTB1_HUMAN  Spectrin beta chain, erythr...    30   5.8   
gi|57015374|sp|P49750|YLPM1_HUMAN  YLP motif containing prot...    30   5.8   
gi|51338794|sp|P78559|MAP1A_HUMAN  Microtubule-associated pr...    30   5.8   
gi|14195666|sp|O60841|IF2P_HUMAN  Eukaryotic translation ini...    30   5.8   
gi|2833266|sp|Q15696|U2R2_HUMAN  U2 small nuclear ribonucleo...    30   7.6   
gi|6919871|sp|O14641|DVL2_HUMAN  Segment polarity protein di...    30   7.6   
gi|38258418|sp|Q15637|SF01_HUMAN  Splicing factor 1 (Zinc fi...    30   7.6   
gi|6175080|sp|P78423|X3CL1_HUMAN  Fractalkine precursor (CX3...    30   7.6   
gi|38372394|sp|Q9NUV9|GIM4_HUMAN  GTPase, IMAP family member...    30   7.6   
gi|55583953|sp|Q8N3L3|TAXB_HUMAN  Beta-taxilin (Muscle deriv...    30   7.6   
gi|3024341|sp|Q09472|EP300_HUMAN  E1A-associated protein p300      30   7.6   
gi|8134347|sp|O43683|BUB1_HUMAN  Mitotic checkpoint serine/t...    30   7.6   
gi|1730009|sp|P12270|TPR_HUMAN  Nucleoprotein TPR                  30   7.6   
gi|20139283|sp|Q9UL16|NESG_HUMAN  Nasopharyngeal epithelium ...    30   7.6   
gi|50403738|sp|P35125|UBP6_HUMAN  Ubiquitin carboxyl-termina...    30   7.6   
gi|6226826|sp|O75330|HMMR_HUMAN  Hyaluronan mediated motilit...    30   7.6   
gi|41017595|sp|O95153|RIP1_HUMAN  Peripheral-type benzodiaze...    30   7.6   
gi|33302627|sp|Q15643|TRIPB_HUMAN  Thyroid receptor interact...    30   7.6   
gi|45645200|sp|Q92599|SEP8_HUMAN  Septin 8                         30   7.6   
gi|27923958|sp|O94833|BPAEA_HUMAN  Bullous pemphigoid antige...    30   7.6   
gi|41019546|sp|Q9D032|SSBP3_MOUSE  Single-stranded DNA-bindi...    29   9.9   
gi|55976496|sp|Q7Z4K8|TM46_HUMAN  Tripartite motif protein 4...    29   9.9   


Alignments

>gi|113992|sp|P02647|APOA1_HUMAN   Apolipoprotein A-I precursor (Apo-AI) (ApoA-I)
          Length = 267

 Score =  475 bits (1223), Expect = e-134
 Identities = 240/267 (89%), Positives = 240/267 (89%)

Query: 1081 MKXXXXXXXXXXXXGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 1140
            MK            GSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
Sbjct: 1    MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 60

Query: 1141 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 1200
            ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
Sbjct: 61   ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 120

Query: 1201 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 1260
            VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
Sbjct: 121  VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 180

Query: 1261 DALRTHLAPYSDXXXXXXXXXXXXXXXNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 1320
            DALRTHLAPYSD               NGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
Sbjct: 181  DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 240

Query: 1321 GLLPVLESFKVSFLSALEEYTKKLNTQ 1347
            GLLPVLESFKVSFLSALEEYTKKLNTQ
Sbjct: 241  GLLPVLESFKVSFLSALEEYTKKLNTQ 267



>gi|59798973|sp|Q9H0K1|SN1L2_HUMAN   Serine/threonine-protein kinase SNF1-like kinase 2 (Qin-induced
           kinase)
          Length = 926

 Score =  363 bits (932), Expect = e-100
 Identities = 183/296 (61%), Positives = 223/296 (75%), Gaps = 21/296 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           TK  VAIKIIDK+QLD  NL+KI+REVQIMKML HPHII+LYQVMET+ M+YLVTEYA  
Sbjct: 42  TKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKN 101

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GEIFD+L  HGR+ E EARRKF QI++AV +CH R IVHRDLKAENLLLD N+NIKIADF
Sbjct: 102 GEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADF 161

Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195
           GF N F  G+LL TWCGSPPYAAPE+FEG++Y+GP++DIWS+GVVLYVLVCGALPFDG T
Sbjct: 162 GFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPT 221

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255
           L  LR RVL G+FRIP+FMS                   +CEHLIR MLVLDP+KRL++ 
Sbjct: 222 LPILRQRVLEGRFRIPYFMS------------------EDCEHLIRRMLVLDPSKRLTIA 263

Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQ 311
           QI +HKWM +   +    R +   Q+ + E  +   NE VL  M  +G+D+++T++
Sbjct: 264 QIKEHKWMLI---EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316



>gi|59803093|sp|P57059|SN1L1_HUMAN   Serine/threonine-protein kinase SNF1-like kinase 1
           (Serine/threonine-protein kinase SNF1LK)
          Length = 783

 Score =  330 bits (847), Expect = 2e-90
 Identities = 164/299 (54%), Positives = 214/299 (71%), Gaps = 26/299 (8%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           TK  VAIKIIDKT+LD  NL+KI+REVQ+MK+L HPHII+LYQVMET+ M+Y+VTE+A  
Sbjct: 49  TKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKN 108

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GE+FD+L ++G ++E EAR+KF QI++AV +CH  +IVHRDLK ENLLLD N++IK+ADF
Sbjct: 109 GEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADF 168

Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195
           GF N +  G+ L TWCGSPPYAAPE+FEGKEY+GP++DIWSLGVVLYVLVCG+LPFDG  
Sbjct: 169 GFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPN 228

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255
           L  LR RVL G+FRIPFFMS                   +CE LIR MLV+DP +R+++ 
Sbjct: 229 LPTLRQRVLEGRFRIPFFMS------------------QDCESLIRRMLVVDPARRITIA 270

Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPL---NEDVLLAMEDMGLDKEQTLQ 311
           QI +H+WM+     P        C           L   +E  L  M+ +G+D+++T++
Sbjct: 271 QIRQHRWMRAEPCLPG-----PACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVE 324



>gi|29840797|sp|Q96L34|MARK4_HUMAN   MAP/microtubule affinity-regulating kinase 4 (MAP/microtubule
           affinity-regulating kinase like 1)
          Length = 752

 Score =  325 bits (834), Expect = 5e-89
 Identities = 159/251 (63%), Positives = 199/251 (79%), Gaps = 18/251 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T + VAIKIIDKTQL+  +L+K+FREV+IMK L HP+I++L++V+ETE+ +YLV EYAS 
Sbjct: 81  TGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASA 140

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GE+FD+LV+HGRM EKEAR KF+QIV+AV++CH +NIVHRDLKAENLLLDA  NIKIADF
Sbjct: 141 GEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADF 200

Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195
           GFSN FT G  L T+CGSPPYAAPELF+GK+YDGP+VDIWSLGV+LY LV G+LPFDG  
Sbjct: 201 GFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHN 260

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255
           L+ LR RVL GK+R+PF+MST                  +CE ++R  LVL+P KR ++E
Sbjct: 261 LKELRERVLRGKYRVPFYMST------------------DCESILRRFLVLNPAKRCTLE 302

Query: 256 QICKHKWMKLG 266
           QI K KW+ +G
Sbjct: 303 QIMKDKWINIG 313



>gi|29337165|sp|P27448|MARK3_HUMAN   MAP/microtubule affinity-regulating kinase 3 (Cdc25C-associated
           protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine
           protein kinase p78) (Ser/Thr protein kinase PAR-1)
           (Protein kinase STK10)
          Length = 776

 Score =  315 bits (806), Expect = 9e-86
 Identities = 159/297 (53%), Positives = 210/297 (70%), Gaps = 41/297 (13%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T + VAIKIIDKTQL+  +L+K+FREV+IMK+L HP+I++L++V+ETE+ +YL+ EYASG
Sbjct: 78  TGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASG 137

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQ-----------------------IVTAVYFCHCRNI 112
           GE+FD+LVAHGRM EKEAR KF+Q                       IV+AV +CH + I
Sbjct: 138 GEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRI 197

Query: 113 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 172
           VHRDLKAENLLLDA++NIKIADFGFSN FT G  L T+CGSPPYAAPELF+GK+YDGP+V
Sbjct: 198 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 257

Query: 173 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLS 232
           D+WSLGV+LY LV G+LPFDG  L+ LR RVL GK+RIPF+MST                
Sbjct: 258 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMST---------------- 301

Query: 233 IAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVD 289
             +CE+L++  LVL+P KR ++EQI K +W+  G  +      +     + +++++D
Sbjct: 302 --DCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID 356



>gi|34395849|sp|Q8IWQ3|BRSK2_HUMAN   BR serine/threonine-protein kinase 2 (Serine/threonine-protein
           kinase 29) (HUSSY-12)
          Length = 736

 Score =  244 bits (623), Expect = 2e-64
 Identities = 129/324 (39%), Positives = 197/324 (60%), Gaps = 24/324 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T Q VAIKI+++ +L E  L K+ RE+ I+K++ HPH+++L+ V E ++ +YLV E+ SG
Sbjct: 41  TCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSG 100

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GE+FD+LV  GR+  KEAR+ F+QI++A+ FCH  +I HRDLK ENLLLD   NI+IADF
Sbjct: 101 GELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADF 160

Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195
           G ++L     LL+T CGSP YA PE+  G++YDG K D+WS GV+L+ L+ GALPFD   
Sbjct: 161 GMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDN 220

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255
           L+ L  +V  G F +P F+                    +C+ L+R M  +D  +RL++E
Sbjct: 221 LRQLLEKVKRGVFHMPHFIP------------------PDCQSLLRGMSEVDAARRLTLE 262

Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQPDGT 315
            I KH W   G  +P  ++ I    Q++    ++ ++ DVL +M  +G  +++       
Sbjct: 263 HIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDL 322

Query: 316 LNLDSDEGEEPSPEALVRYLSMRR 339
           L+      EE + E ++ +L + R
Sbjct: 323 LS------EEENQEKMIYFLLLDR 340



>gi|34395684|sp|Q8TDC3|KI11_HUMAN   Probable serine/threonine-protein kinase KIAA1811
          Length = 794

 Score =  243 bits (619), Expect = 4e-64
 Identities = 134/328 (40%), Positives = 197/328 (60%), Gaps = 30/328 (9%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T Q VAIKI+++ +L E  L K+ RE+ I+K++ HPH+++L+ V E ++ +YLV E+ SG
Sbjct: 72  TGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSG 131

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GE+FD+LV  GR+  KEAR+ F+QIV+A+ FCH  +I HRDLK ENLLLD   NI+IADF
Sbjct: 132 GELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADF 191

Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195
           G ++L     LL+T CGSP YA PE+ +G++YDG + D+WS GV+L+ L+ GALPFD   
Sbjct: 192 GMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDN 251

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255
           L+ L  +V  G F +P F+                    +C+ L+R M+ ++P KRLS+E
Sbjct: 252 LRQLLEKVKRGVFHMPHFIP------------------PDCQSLLRGMIEVEPEKRLSLE 293

Query: 256 QICKHKWMKLG--DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGL--DKEQTLQ 311
           QI KH W   G  + DP  +        ++       L+ DVL +M  +G   D+E+  +
Sbjct: 294 QIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHR 353

Query: 312 PDGTLNLDSDEGEEPSPEALVRYLSMRR 339
                       EE + E ++ YL + R
Sbjct: 354 --------ELRSEEENQEKMIYYLLLDR 373



>gi|20178276|sp|P54646|AAPK2_HUMAN   5'-AMP-activated protein kinase, catalytic alpha-2 chain (AMPK
           alpha-2 chain)
          Length = 552

 Score =  238 bits (608), Expect = 8e-63
 Identities = 122/278 (43%), Positives = 178/278 (64%), Gaps = 25/278 (8%)

Query: 14  QETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           Q T   VA+KI+++ ++   + + KI RE+Q +K+  HPHII+LYQV+ T    ++V EY
Sbjct: 36  QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEY 95

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
            SGGE+FD++  HGR+ E EARR F+QI++AV +CH   +VHRDLK EN+LLDA++N KI
Sbjct: 96  VSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKI 155

Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           ADFG SN+ + G+ L+T CGSP YAAPE+  G+ Y GP+VDIWS GV+LY L+CG LPFD
Sbjct: 156 ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD 215

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
              +  L  ++  G F IP +++  +                    L+ HML +DP KR 
Sbjct: 216 DEHVPTLFKKIRGGVFYIPEYLNRSVAT------------------LLMHMLQVDPLKRA 257

Query: 253 SMEQICKHKWMK------LGDADPNFDRLIAECQQLKE 284
           +++ I +H+W K      L   DP++D  + + + +KE
Sbjct: 258 TIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKE 295



>gi|20178277|sp|Q13131|AAPK1_HUMAN   5'-AMP-activated protein kinase, catalytic alpha-1 chain (AMPK
           alpha-1 chain)
          Length = 550

 Score =  238 bits (606), Expect = 1e-62
 Identities = 142/376 (37%), Positives = 211/376 (56%), Gaps = 54/376 (14%)

Query: 16  TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T   VA+KI+++ ++   + + KI RE+Q +K+  HPHII+LYQV+ T   I++V EY S
Sbjct: 40  TGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVS 99

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GGE+FD++  +GR+ EKE+RR F+QI++ V +CH   +VHRDLK EN+LLDA++N KIAD
Sbjct: 100 GGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIAD 159

Query: 135 FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194
           FG SN+ + G+ L+T CGSP YAAPE+  G+ Y GP+VDIWS GV+LY L+CG LPFD  
Sbjct: 160 FGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDD 219

Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSM 254
            +  L  ++  G F  P +++  ++                   L++HML +DP KR S+
Sbjct: 220 HVPTLFKKICDGIFYTPQYLNPSVI------------------SLLKHMLQVDPMKRASI 261

Query: 255 EQICKHKWMK------LGDADPNFDRLIAECQQLKE--------ERQV----------DP 290
           + I +H+W K      L   DP++   + + + LKE        E +V          DP
Sbjct: 262 KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDP 321

Query: 291 LNEDVLLAMEDMGLDKE------QTLQPDGTLNLDSDEGEEPSPEA---LVRYLSMRRHT 341
           L     L +++  +  E       T  PD    LD      P PE    LV      RHT
Sbjct: 322 LAVAYHLIIDNRRIMNEAKDFYLATSPPDSF--LDDHHLTRPHPERVPFLVAETPRARHT 379

Query: 342 VGVADPRTEVMEDLQK 357
           +   +P+    + ++K
Sbjct: 380 LDELNPQKSKHQGVRK 395



>gi|14424095|sp|O60285|ARK5_HUMAN   AMPK-related protein kinase 5
          Length = 661

 Score =  224 bits (570), Expect = 2e-58
 Identities = 114/268 (42%), Positives = 171/268 (63%), Gaps = 25/268 (9%)

Query: 18  QLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           ++VAIK I K ++ DE+++  I RE++IM  L HPHII +Y+V E +  I ++ EYAS G
Sbjct: 79  RVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKG 138

Query: 77  EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136
           E++D++    R++E+E R  F+QIV+AV++CH   +VHRDLK EN+LLD N NIKIADFG
Sbjct: 139 ELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFG 198

Query: 137 FSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196
            SNL+   + L+T+CGSP YA+PE+  G+ Y GP+VD W+LGV+LY LV G +PFDG   
Sbjct: 199 LSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDH 258

Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256
           +NL  ++ SG++R P                      ++   LIR ML+++P++R ++E 
Sbjct: 259 KNLIRQISSGEYREP-------------------TQPSDARGLIRWMLMVNPDRRATIED 299

Query: 257 ICKHKWMKLGDADPNFDRLIAECQQLKE 284
           I  H W+  G     +   + +C  L +
Sbjct: 300 IANHWWVNWG-----YKSSVCDCDALHD 322



>gi|50400857|sp|Q14680|MELK_HUMAN   Maternal embryonic leucine zipper kinase (hMELK) (Protein kinase
           PK38) (hPK38)
          Length = 651

 Score =  195 bits (496), Expect = 8e-50
 Identities = 101/250 (40%), Positives = 151/250 (60%), Gaps = 21/250 (8%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T ++VAIKI+DK  L  + L +I  E++ +K L H HI +LY V+ET   I++V EY  G
Sbjct: 33  TGEMVAIKIMDKNTLGSD-LPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPG 91

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GE+FD++++  R++E+E R  F+QIV+AV + H +   HRDLK ENLL D    +K+ DF
Sbjct: 92  GELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDF 151

Query: 136 GF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           G            L+T CGS  YAAPEL +GK Y G + D+WS+G++LYVL+CG LPFD 
Sbjct: 152 GLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDD 211

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253
             +  L  +++ GK+ +P ++S   +                   L++ ML +DP KR+S
Sbjct: 212 DNVMALYKKIMRGKYDVPKWLSPSSI------------------LLLQQMLQVDPKKRIS 253

Query: 254 MEQICKHKWM 263
           M+ +  H W+
Sbjct: 254 MKNLLNHPWI 263



>gi|30316282|sp|Q9BXA7|ST22A_HUMAN   Serine/threonine-protein kinase 22A (Testis-specific kinase 1)
           (TSK-1) (Testis-specific serine kinase 1) (TSSK-1)
           (Serine/threonine-protein kinase FKSG81)
          Length = 367

 Score =  186 bits (471), Expect = 6e-47
 Identities = 119/342 (34%), Positives = 183/342 (53%), Gaps = 38/342 (11%)

Query: 12  FLQETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETER-MIYLV 69
           + +  K  VAIKIID+ +   + L+K   RE++I+ ML H  II+ Y++ ET    +Y+V
Sbjct: 30  YSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIV 89

Query: 70  TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
            E A  G++ + +   G + E EAR+KF Q+  A+ +CH  ++VHRDLK +NLLLD + N
Sbjct: 90  MELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFN 149

Query: 130 IKIADFGFSNLFTPGQ-----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184
           IK++DF FS            L KT+CGSP YAAPE+ +G  Y     DIWSLGV+LY++
Sbjct: 150 IKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIM 209

Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244
           VCG++P+D S ++ +    +  + R+ F  S  L                EC+ LI HML
Sbjct: 210 VCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLT--------------GECKDLIYHML 253

Query: 245 VLDPNKRLSMEQICKHKWMK-LGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMG 303
             D N+RL +++I  H WM+      P+    +A  ++ +  R  +P      L   + G
Sbjct: 254 QPDVNRRLHIDEILSHCWMQPKARGSPS----VAINKEGESSRGTEP------LWTPEPG 303

Query: 304 LDKEQT--LQPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVG 343
            DK+    L+P+G     +    E  PE     +S +   +G
Sbjct: 304 SDKKSATKLEPEGEAQPQAQ--PETKPEGTAMQMSRQSEILG 343



>gi|30316269|sp|Q96PF2|ST22B_HUMAN   Serine/threonine-protein kinase 22B (Testis-specific kinase 2)
           (TSK-2) (Testis-specific serine kinase 2) (TSSK-2)
           (DiGeorge syndrome protein G)
          Length = 358

 Score =  168 bits (426), Expect = 1e-41
 Identities = 94/260 (36%), Positives = 153/260 (58%), Gaps = 23/260 (8%)

Query: 12  FLQETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMET-ERMIYLV 69
           + +  K  VA+KIID+ +   + +++   RE+ I+  + H  II+ Y++ ET +  IY++
Sbjct: 30  YSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYII 89

Query: 70  TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
            E    G++ + +   G + E  AR+ F+Q+ +AV +CH  +IVHRDLK ENLLLD + N
Sbjct: 90  MELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFN 149

Query: 130 IKIADFGFSNLF---TPGQLL--KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184
           IK++DFGFS      + G+++  KT+CGS  YAAPE+ +   Y     DIWSLGV+LY++
Sbjct: 150 IKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIM 209

Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244
           VCG++P+D S ++ +    +  + R+ F  S  L                EC+ LI  ML
Sbjct: 210 VCGSMPYDDSDIRKMLR--IQKEHRVDFPRSKNLT--------------CECKDLIYRML 253

Query: 245 VLDPNKRLSMEQICKHKWMK 264
             D ++RL +++I  H W++
Sbjct: 254 QPDVSQRLHIDEILSHSWLQ 273



>gi|9973393|sp|P57058|HUNK_HUMAN   Hormonally up-regulated neu tumor-associated kinase
           (Serine/threonine-protein kinase MAK-V) (B19)
          Length = 714

 Score =  166 bits (421), Expect = 4e-41
 Identities = 100/253 (39%), Positives = 143/253 (56%), Gaps = 21/253 (8%)

Query: 16  TKQLVAIKIIDKTQLDEENL--KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           T + VAIK+IDK +  ++    K + RE QI +M+ HP+I +L  ++ETE   YLV E  
Sbjct: 84  TGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELC 143

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
            GG +   +    R+ E EARR  +Q+++AV   H   +VHRDLK ENLLLD + NIK+ 
Sbjct: 144 PGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLI 203

Query: 134 DFGFSN---LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           DFG SN   +        T CGSP YAAPEL   K+Y GPK+D+WS+GV +Y ++ G LP
Sbjct: 204 DFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLP 262

Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
           F   T++    R L  K      M    +  L  +L  G +S       +R +L  DP K
Sbjct: 263 F---TVEPFSLRALYQK------MVDKEMNPLPTQLSTGAIS------FLRSLLEPDPVK 307

Query: 251 RLSMEQICKHKWM 263
           R +++Q   ++W+
Sbjct: 308 RPNIQQALANRWL 320



>gi|30316270|sp|Q96PN8|ST22C_HUMAN   Serine/threonine-protein kinase 22C (Testis-specific kinase 3)
           (TSK-3) (Testis-specific serine kinase 3) (TSSK-3)
          Length = 268

 Score =  164 bits (415), Expect = 2e-40
 Identities = 93/256 (36%), Positives = 152/256 (59%), Gaps = 22/256 (8%)

Query: 12  FLQETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMET-ERMIYLV 69
           F ++ ++ VAIK+IDK    EE +++   RE+QI++ L H +II++Y+++E+ +  I LV
Sbjct: 28  FSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKICLV 87

Query: 70  TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
            E A GG++FD ++  G + E  A+  F+Q+V A+ +CH   + HRDLK EN LL    N
Sbjct: 88  MELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQG-FN 146

Query: 130 IKIADFGFSNLFTPG--QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187
           +K+ DFGF+ +      +L +T+CGS  YAAPE+ +G  +D  K D+WS+GVVLYV++C 
Sbjct: 147 LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCA 206

Query: 188 ALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247
           +LPFD + +  +  +   G    P  +S                  A+C+ L++ +L  D
Sbjct: 207 SLPFDDTDIPKMLWQQQKG-VSFPTHLSIS----------------ADCQDLLKRLLEPD 249

Query: 248 PNKRLSMEQICKHKWM 263
              R S+E++  H W+
Sbjct: 250 MILRPSIEEVSWHPWL 265



>gi|27805738|sp|Q9UQB9|AURKC_HUMAN   Serine/threonine-protein kinase 13 (Aurora/Ipl1/Eg2 protein 2)
           (Aurora/Ipl1-related kinase 3) (Aurora-C)
          Length = 309

 Score =  162 bits (411), Expect = 6e-40
 Identities = 92/271 (33%), Positives = 148/271 (54%), Gaps = 26/271 (9%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71
           L+E+  +VA+K++ K+Q+++E L+ ++ RE++I   L HP+I+RLY      R +YL+ E
Sbjct: 62  LKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILE 121

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
           YA  GE++  L    ++ E+      +++  A+ +CH + ++HRD+K ENLLL     +K
Sbjct: 122 YAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVK 181

Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           IADFG+S + TP    KT CG+  Y  PE+ EG+ YD  KVD+W +GV+ Y L+ G  PF
Sbjct: 182 IADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD-EKVDLWCIGVLCYELLVGYPPF 239

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
           + ++      R+L    R P  M  G                     LI  +L   P +R
Sbjct: 240 ESASHSETYRRILKVDVRFPLSMPLG------------------ARDLISRLLRYQPLER 281

Query: 252 LSMEQICKHKWMKLGDADPNFDRLIAECQQL 282
           L + QI KH W++      +  R++  C Q+
Sbjct: 282 LPLAQILKHPWVQ-----AHSRRVLPPCAQM 307



>gi|2499586|sp|Q16566|KCC4_HUMAN   Calcium/calmodulin-dependent protein kinase type IV (CAM kinase-GR)
           (CaMK IV)
          Length = 473

 Score =  160 bits (404), Expect = 4e-39
 Identities = 102/253 (40%), Positives = 153/253 (60%), Gaps = 25/253 (9%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T++  A+K++ KT +D    KKI R E+ ++  L HP+II+L ++ ET   I LV E  +
Sbjct: 68  TQKPYALKVLKKT-VD----KKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVT 122

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA---NLNIK 131
           GGE+FD +V  G  +E++A    KQI+ AV + H   IVHRDLK ENLL      +  +K
Sbjct: 123 GGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLK 182

Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           IADFG S +     L+KT CG+P Y APE+  G  Y GP+VD+WS+G++ Y+L+CG  PF
Sbjct: 183 IADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY-GPEVDMWSVGIITYILLCGFEPF 241

Query: 192 -DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
            D    Q +  R+L+ ++   +F+S    P  D+      +S+   + L+R ++VLDP K
Sbjct: 242 YDERGDQFMFRRILNCEY---YFIS----PWWDE------VSL-NAKDLVRKLIVLDPKK 287

Query: 251 RLSMEQICKHKWM 263
           RL+  Q  +H W+
Sbjct: 288 RLTTFQALQHPWV 300



>gi|3122301|sp|Q14012|KCC1A_HUMAN   Calcium/calmodulin-dependent protein kinase type 1 (CaM kinase I)
           (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)
          Length = 370

 Score =  156 bits (395), Expect = 4e-38
 Identities = 95/272 (34%), Positives = 144/272 (52%), Gaps = 26/272 (9%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           + T++LVAIK I K  L+ +    +  E+ ++  + HP+I+ L  + E+   +YL+ +  
Sbjct: 40  KRTQKLVAIKCIAKEALEGKE-GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLV 98

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL---LDANLNI 130
           SGGE+FD +V  G   E++A R   Q++ AV + H   IVHRDLK ENLL   LD +  I
Sbjct: 99  SGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKI 158

Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
            I+DFG S +  PG +L T CG+P Y APE+   K Y    VD WS+GV+ Y+L+CG  P
Sbjct: 159 MISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPP 217

Query: 191 FDGSTLQNLRARVLSGKFRI--PFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248
           F       L  ++L  ++    P++                       +  IRH++  DP
Sbjct: 218 FYDENDAKLFEQILKAEYEFDSPYWDDIS----------------DSAKDFIRHLMEKDP 261

Query: 249 NKRLSMEQICKHKWMKLGDA--DPNFDRLIAE 278
            KR + EQ  +H W+  GD   D N  + ++E
Sbjct: 262 EKRFTCEQALQHPWI-AGDTALDKNIHQSVSE 292



>gi|56404610|sp|Q8IU85|KCC1D_HUMAN   Calcium/calmodulin-dependent protein kinase type 1D (CaM kinase ID)
           (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI
           delta) (Camk1D) (CamKI-like protein kinase) (CKLiK)
          Length = 385

 Score =  150 bits (380), Expect = 2e-36
 Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 23/253 (9%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T +L A+K I K  L  +    I  E+ +++ + H +I+ L  + E+   +YLV +  SG
Sbjct: 45  TGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSG 103

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKI 132
           GE+FD +V  G   EK+A    +Q++ AVY+ H   IVHRDLK ENLL    D    I I
Sbjct: 104 GELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMI 163

Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           +DFG S +   G ++ T CG+P Y APE+   K Y    VD WS+GV+ Y+L+CG  PF 
Sbjct: 164 SDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFY 222

Query: 193 GSTLQNLRARVLSGKFRI--PFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
                 L  ++L  ++    P++                       +  IR+++  DPNK
Sbjct: 223 DENDSKLFEQILKAEYEFDSPYWDDIS----------------DSAKDFIRNLMEKDPNK 266

Query: 251 RLSMEQICKHKWM 263
           R + EQ  +H W+
Sbjct: 267 RYTCEQAARHPWI 279



>gi|27923855|sp|O14965|STK6_HUMAN   Serine/threonine-protein kinase 6 (Serine/threonine kinase 15)
           (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1)
           (hARK1) (Aurora-A) (Breast-tumor-amplified kinase)
          Length = 403

 Score =  149 bits (377), Expect = 5e-36
 Identities = 81/259 (31%), Positives = 140/259 (54%), Gaps = 21/259 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           +++K ++A+K++ K QL++  ++ ++ REV+I   L HP+I+RLY        +YL+ EY
Sbjct: 153 KQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEY 212

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
           A  G ++  L    +  E+       ++  A+ +CH + ++HRD+K ENLLL +   +KI
Sbjct: 213 APLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKI 272

Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           ADFG+S +  P     T CG+  Y  PE+ EG+ +D  KVD+WSLGV+ Y  + G  PF+
Sbjct: 273 ADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMHD-EKVDLWSLGVLCYEFLVGKPPFE 330

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
            +T Q    R+   +F  P F++ G                     LI  +L  +P++R 
Sbjct: 331 ANTYQETYKRISRVEFTFPDFVTEG------------------ARDLISRLLKHNPSQRP 372

Query: 253 SMEQICKHKWMKLGDADPN 271
            + ++ +H W+    + P+
Sbjct: 373 MLREVLEHPWITANSSKPS 391



>gi|27805737|sp|Q96GD4|AURKB_HUMAN   Serine/threonine-protein kinase 12 (Aurora- and Ipl1-like
           midbody-associated protein 1) (AIM-1)
           (Aurora/IPL1-related kinase 2) (Aurora-related kinase 2)
           (STK-1) (Aurora-B)
          Length = 344

 Score =  148 bits (373), Expect = 1e-35
 Identities = 81/247 (32%), Positives = 138/247 (55%), Gaps = 21/247 (8%)

Query: 19  LVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           +VA+K++ K+Q+++E ++ ++ RE++I   L HP+I+RLY      R IYL+ EYA  GE
Sbjct: 102 IVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGE 161

Query: 78  IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           ++  L       E+      +++  A+ +CH + ++HRD+K ENLLL     +KIADFG+
Sbjct: 162 LYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGW 221

Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ 197
           S +  P    KT CG+  Y  PE+ EG+ ++  KVD+W +GV+ Y L+ G  PF+ ++  
Sbjct: 222 S-VHAPSLRRKTMCGTLDYLPPEMIEGRMHN-EKVDLWCIGVLCYELLVGNPPFESASHN 279

Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQI 257
               R++    + P  + TG    + K              L+RH    +P++RL + Q+
Sbjct: 280 ETYRRIVKVDLKFPASVPTGAQDLISK--------------LLRH----NPSERLPLAQV 321

Query: 258 CKHKWMK 264
             H W++
Sbjct: 322 SAHPWVR 328



>gi|125536|sp|P15735|PHKG2_HUMAN   Phosphorylase b kinase gamma catalytic chain, testis/liver isoform
           (PHK-gamma-T) (Phosphorylase kinase gamma subunit 2)
           (PSK-C3)
          Length = 406

 Score =  146 bits (368), Expect = 6e-35
 Identities = 91/256 (35%), Positives = 142/256 (55%), Gaps = 26/256 (10%)

Query: 21  AIKIIDKT--QLDEENLKKIF----REVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYA 73
           A+KI++ T  +L  E L+++     RE  I++ +  HPHII L    E+   ++LV +  
Sbjct: 51  AVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLM 110

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
             GE+FD+L     ++EKE R   + ++ AV F H  NIVHRDLK EN+LLD N+ I+++
Sbjct: 111 RKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLS 170

Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELF-----EGKEYDGPKVDIWSLGVVLYVLVCGA 188
           DFGFS    PG+ L+  CG+P Y APE+      E     G +VD+W+ GV+L+ L+ G+
Sbjct: 171 DFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGS 230

Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248
            PF       +   ++ G+++   F S    PE D R        +  + LI  +L +DP
Sbjct: 231 PPFWHRRQILMLRMIMEGQYQ---FSS----PEWDDR-------SSTVKDLISRLLQVDP 276

Query: 249 NKRLSMEQICKHKWMK 264
             RL+ EQ  +H + +
Sbjct: 277 EARLTAEQALQHPFFE 292



>gi|6685284|sp|O96017|CHK2_HUMAN   Serine/threonine-protein kinase Chk2 (Cds1)
          Length = 543

 Score =  145 bits (365), Expect = 1e-34
 Identities = 93/279 (33%), Positives = 148/279 (53%), Gaps = 27/279 (9%)

Query: 12  FLQETKQLVAIKIIDKTQL------DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           F ++T + VAIKII K +       + +    +  E++I+K L HP II++    + E  
Sbjct: 238 FERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDY 297

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL- 124
            Y+V E   GGE+FD +V + R+ E   +  F Q++ AV + H   I+HRDLK EN+LL 
Sbjct: 298 -YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS 356

Query: 125 --DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELF--EGKEYDGPKVDIWSLGVV 180
             + +  IKI DFG S +     L++T CG+P Y APE+    G       VD WSLGV+
Sbjct: 357 SQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVI 416

Query: 181 LYVLVCGALPF-DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239
           L++ + G  PF +  T  +L+ ++ SGK+          +PE+   +    L       L
Sbjct: 417 LFICLSGYPPFSEHRTQVSLKDQITSGKY--------NFIPEVWAEVSEKALD------L 462

Query: 240 IRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAE 278
           ++ +LV+DP  R + E+  +H W++  D    F  L++E
Sbjct: 463 VKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSE 501



>gi|17379144|sp|P11801|KPSH1_HUMAN   Serine/threonine-protein kinase H1 (PSK-H1)
          Length = 424

 Score =  143 bits (360), Expect = 5e-34
 Identities = 85/253 (33%), Positives = 134/253 (52%), Gaps = 22/253 (8%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T+Q  AIK+I+      E  +    E+++++ + H +II+L +V ET+  +Y+V E A+G
Sbjct: 120 TRQPYAIKMIETKY--REGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATG 177

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKI 132
           GE+FD ++A G   E++A R  + ++  V + H   I HRDLK ENLL      +  I I
Sbjct: 178 GELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIII 237

Query: 133 ADFGFSNLFTPGQ--LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
            DFG ++    G   L+KT CG+P Y APE+   K Y    VD+W+LGV+ Y+L+ G +P
Sbjct: 238 TDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN-SVDMWALGVIAYILLSGTMP 296

Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
           F+      L  ++L GK+      S    P +    K            I  +L +DP  
Sbjct: 297 FEDDNRTRLYRQILRGKYS----YSGEPWPSVSNLAK----------DFIDRLLTVDPGA 342

Query: 251 RLSMEQICKHKWM 263
           R++  Q  +H W+
Sbjct: 343 RMTALQALRHPWV 355



>gi|2833281|sp|Q16816|PHKG1_HUMAN   Phosphorylase b kinase gamma catalytic chain, skeletal muscle
           isoform (Phosphorylase kinase gamma subunit 1)
          Length = 387

 Score =  142 bits (359), Expect = 6e-34
 Identities = 87/262 (33%), Positives = 136/262 (51%), Gaps = 27/262 (10%)

Query: 16  TKQLVAIKIIDKT---QLDEENLKKI----FREVQIMKMLC-HPHIIRLYQVMETERMIY 67
           T Q  A+K+ID T       E ++++     +EV I++ +  HP+II+L    ET    +
Sbjct: 42  TSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFF 101

Query: 68  LVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN 127
           LV +    GE+FD+L     ++EKE R+  + ++  +   H  NIVHRDLK EN+LLD N
Sbjct: 102 LVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDN 161

Query: 128 LNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD-----GPKVDIWSLGVVLY 182
           +NIK+ DFGFS    PG+ L+  CG+P Y APE+ E    +     G +VD+WS GV++Y
Sbjct: 162 MNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMY 221

Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRH 242
            L+ G+ PF       +   ++SG ++          PE D             + L+  
Sbjct: 222 TLLAGSPPFWHRKQMLMLRMIMSGNYQFG-------SPEWDDYSDT-------VKDLVSR 267

Query: 243 MLVLDPNKRLSMEQICKHKWMK 264
            LV+ P  R + E+   H + +
Sbjct: 268 FLVVQPQNRYTAEEALAHPFFQ 289



>gi|38605718|sp|P53355|DAPK1_HUMAN   Death-associated protein kinase 1 (DAP kinase 1)
          Length = 1432

 Score =  142 bits (359), Expect = 6e-34
 Identities = 88/243 (36%), Positives = 129/243 (53%), Gaps = 23/243 (9%)

Query: 38  IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKF 97
           I REV I+K + HP++I L++V E +  + L+ E  +GGE+FD L     + E+EA    
Sbjct: 61  IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL 120

Query: 98  KQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL---NIKIADFGFSNLFTPGQLLKTWCGS 153
           KQI+  VY+ H   I H DLK EN +LLD N+    IKI DFG ++    G   K   G+
Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180

Query: 154 PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARV--LSGKFRIP 211
           P + APE+    E  G + D+WS+GV+ Y+L+ GA PF G T Q   A V  ++ +F   
Sbjct: 181 PEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDE 239

Query: 212 FFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPN 271
           +F +T                 A  +  IR +LV DP KR++++   +H W+K  D    
Sbjct: 240 YFSNTS----------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQA 283

Query: 272 FDR 274
             R
Sbjct: 284 LSR 286



>gi|20177970|sp|Q9UQM7|KCC2A_HUMAN   Calcium/calmodulin-dependent protein kinase type II alpha chain
           (CaM-kinase II alpha chain) (CaM kinase II alpha
           subunit) (CaMK-II alpha subunit)
          Length = 478

 Score =  141 bits (355), Expect = 2e-33
 Identities = 86/250 (34%), Positives = 135/250 (54%), Gaps = 19/250 (7%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           Q  A KII+  +L   + +K+ RE +I ++L HP+I+RL+  +  E   YL+ +  +GGE
Sbjct: 37  QEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGE 96

Query: 78  IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIAD 134
           +F+ +VA    +E +A    +QI+ AV  CH   +VHRDLK ENLLL + L    +K+AD
Sbjct: 97  LFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLAD 156

Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           FG +  +    Q    + G+P Y +PE+     Y G  VD+W+ GV+LY+L+ G  PF  
Sbjct: 157 FGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWD 215

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253
                L  ++ +G +  P        PE D           E + LI  ML ++P+KR++
Sbjct: 216 EDQHRLYQQIKAGAYDFP-------SPEWD-------TVTPEAKDLINKMLTINPSKRIT 261

Query: 254 MEQICKHKWM 263
             +  KH W+
Sbjct: 262 AAEALKHPWI 271



>gi|56404655|sp|Q96NX5|KCC1G_HUMAN   Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase IG)
           (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI
           gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
          Length = 476

 Score =  140 bits (354), Expect = 2e-33
 Identities = 86/253 (33%), Positives = 130/253 (51%), Gaps = 25/253 (9%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T +L A+K I K+    ++   +  E+ ++K + H +I+ L  + E+    YLV +  SG
Sbjct: 45  TGKLFALKCIKKSPAFRDS--SLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSG 102

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANLNIKI 132
           GE+FD ++  G   EK+A    +Q+++AV + H   IVHRDLK ENLL    + N  I I
Sbjct: 103 GELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMI 162

Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
            DFG S +   G ++ T CG+P Y APE+   K Y    VD WS+GV+ Y+L+CG  PF 
Sbjct: 163 TDFGLSKMEQNG-IMSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVITYILLCGYPPFY 220

Query: 193 GSTLQNLRARVLSG--KFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
             T   L  ++  G  +F  PF+                       +  I H+L  DPN+
Sbjct: 221 EETESKLFEKIKEGYYEFESPFWDDIS----------------ESAKDFICHLLEKDPNE 264

Query: 251 RLSMEQICKHKWM 263
           R + E+   H W+
Sbjct: 265 RYTCEKALSHPWI 277



>gi|7531055|sp|O14757|CHK1_HUMAN   Serine/threonine-protein kinase Chk1
          Length = 476

 Score =  140 bits (352), Expect = 4e-33
 Identities = 77/182 (42%), Positives = 111/182 (60%), Gaps = 8/182 (4%)

Query: 16  TKQLVAIKIID-KTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           T++ VA+KI+D K  +D  EN+KK   E+ I KML H ++++ Y       + YL  EY 
Sbjct: 31  TEEAVAVKIVDMKRAVDCPENIKK---EICINKMLNHENVVKFYGHRREGNIQYLFLEYC 87

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
           SGGE+FD +     M E +A+R F Q++  V + H   I HRD+K ENLLLD   N+KI+
Sbjct: 88  SGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKIS 147

Query: 134 DFGFSNLF---TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           DFG + +F      +LL   CG+ PY APEL + +E+    VD+WS G+VL  ++ G LP
Sbjct: 148 DFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELP 207

Query: 191 FD 192
           +D
Sbjct: 208 WD 209



>gi|12643414|sp|Q13557|KCC2D_HUMAN   Calcium/calmodulin-dependent protein kinase type II delta chain
           (CaM-kinase II delta chain) (CaM kinase II delta
           subunit) (CaMK-II delta subunit)
          Length = 499

 Score =  139 bits (351), Expect = 5e-33
 Identities = 87/252 (34%), Positives = 134/252 (53%), Gaps = 19/252 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T Q  A KII+  +L   + +K+ RE +I ++L HP+I+RL+  +  E   YLV +  +G
Sbjct: 36  TGQGYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKI 132
           GE+F+ +VA    +E +A    +QI+ +V  CH   IVHRDLK ENLLL +      +K+
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKL 155

Query: 133 ADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           ADFG +  +    Q    + G+P Y +PE+     Y G  VD+W+ GV+LY+L+ G  PF
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDMWACGVILYILLVGYPPF 214

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
                  L  ++ +G +  P        PE D           E + LI  ML ++P KR
Sbjct: 215 WDEDQHRLYQQIKAGAYDFP-------SPEWD-------TVTPEAKDLINKMLTINPAKR 260

Query: 252 LSMEQICKHKWM 263
           ++  +  KH W+
Sbjct: 261 ITASEALKHPWI 272



>gi|51316189|sp|O00444|PLK4_HUMAN   Serine/threonine-protein kinase PLK4 (Polo-like kinase 4) (PLK-4)
           (Serine/threonine protein kinase Sak)
           (Serine/threonine-protein kinase 18)
          Length = 970

 Score =  139 bits (351), Expect = 5e-33
 Identities = 88/257 (34%), Positives = 132/257 (51%), Gaps = 22/257 (8%)

Query: 20  VAIKIIDKTQLDEENL-KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78
           VAIK+IDK  + +  + +++  EV+I   L HP I+ LY   E    +YLV E    GE+
Sbjct: 38  VAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEM 97

Query: 79  FDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
             +L    +  +E EAR    QI+T + + H   I+HRDL   NLLL  N+NIKIADFG 
Sbjct: 98  NRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGL 157

Query: 138 -SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196
            + L  P +   T CG+P Y +PE+   +   G + D+WSLG + Y L+ G  PFD  T+
Sbjct: 158 ATQLKMPHEKHYTLCGTPNYISPEI-ATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTV 216

Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256
           +N   +V+   + +P F+S                   E + LI  +L  +P  RLS+  
Sbjct: 217 KNTLNKVVLADYEMPTFLS------------------IEAKDLIHQLLRRNPADRLSLSS 258

Query: 257 ICKHKWMKLGDADPNFD 273
           +  H +M    +  + D
Sbjct: 259 VLDHPFMSRNSSTKSKD 275



>gi|38604691|sp|O43293|DAPK3_HUMAN   Death-associated protein kinase 3 (DAP kinase 3) (DAP-like kinase)
           (Dlk) (ZIP-kinase)
          Length = 454

 Score =  139 bits (349), Expect = 9e-33
 Identities = 85/252 (33%), Positives = 134/252 (53%), Gaps = 23/252 (9%)

Query: 21  AIKIIDKTQLDEE----NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           A K I K +L       + ++I REV I++ + HP+II L+ + E +  + L+ E  SGG
Sbjct: 40  AAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGG 99

Query: 77  EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL---NIKI 132
           E+FD L     + E EA +  KQI+  V++ H + I H DLK EN +LLD N+    IK+
Sbjct: 100 ELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKL 159

Query: 133 ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
            DFG ++    G   K   G+P + APE+    E  G + D+WS+GV+ Y+L+ GA PF 
Sbjct: 160 IDFGIAHKIEAGNEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFL 218

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
           G T Q     + +  +            + D+   +    +A  +  IR +LV DP +R+
Sbjct: 219 GETKQETLTNISAVNY------------DFDEEYFSNTSELA--KDFIRRLLVKDPKRRM 264

Query: 253 SMEQICKHKWMK 264
           ++ Q  +H W+K
Sbjct: 265 TIAQSLEHSWIK 276



>gi|12643413|sp|Q13554|KCC2B_HUMAN   Calcium/calmodulin-dependent protein kinase type II beta chain
           (CaM-kinase II beta chain) (CaM kinase II beta subunit)
           (CaMK-II beta subunit)
          Length = 664

 Score =  139 bits (349), Expect = 9e-33
 Identities = 86/247 (34%), Positives = 133/247 (53%), Gaps = 19/247 (7%)

Query: 21  AIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFD 80
           A KII+  +L   + +K+ RE +I ++L H +I+RL+  +  E   YLV +  +GGE+F+
Sbjct: 41  AAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFE 100

Query: 81  HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIADFGF 137
            +VA    +E +A    +QI+ AV  CH   +VHRDLK ENLLL +      +K+ADFG 
Sbjct: 101 DIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGL 160

Query: 138 S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196
           +  +    Q    + G+P Y +PE+   KE  G  VDIW+ GV+LY+L+ G  PF     
Sbjct: 161 AIEVQGDQQAWFGFAGTPGYLSPEVLR-KEAYGKPVDIWACGVILYILLVGYPPFWDEDQ 219

Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256
             L  ++ +G +  P        PE D           E ++LI  ML ++P KR++  +
Sbjct: 220 HKLYQQIKAGAYDFP-------SPEWD-------TVTPEAKNLINQMLTINPAKRITAHE 265

Query: 257 ICKHKWM 263
             KH W+
Sbjct: 266 ALKHPWV 272



>gi|20178304|sp|Q13555|KCC2G_HUMAN   Calcium/calmodulin-dependent protein kinase type II gamma chain
           (CaM-kinase II gamma chain) (CaM kinase II gamma
           subunit) (CaMK-II gamma subunit)
          Length = 472

 Score =  138 bits (348), Expect = 1e-32
 Identities = 87/250 (34%), Positives = 134/250 (53%), Gaps = 19/250 (7%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           Q  A KII+  +L   + +K+ RE +I ++L HP+I+RL+  +  E   YLV +  +GGE
Sbjct: 38  QEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGE 97

Query: 78  IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IKIAD 134
           +F+ +VA    +E +A     QI+ +V   H  +IVHRDLK ENLLL +      +K+AD
Sbjct: 98  LFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLAD 157

Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           FG +  +    Q    + G+P Y +PE+     Y G  VDIW+ GV+LY+L+ G  PF  
Sbjct: 158 FGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWD 216

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253
                L  ++ +G +  P        PE D           E ++LI  ML ++P KR++
Sbjct: 217 EDQHKLYQQIKAGAYDFP-------SPEWD-------TVTPEAKNLINQMLTINPAKRIT 262

Query: 254 MEQICKHKWM 263
            +Q  KH W+
Sbjct: 263 ADQALKHPWV 272



>gi|37999482|sp|O75582|KS6A5_HUMAN   Ribosomal protein S6 kinase alpha 5 (Nuclear mitogen-and
           stress-activated protein kinase-1) (90 kDa ribosomal
           protein S6 kinase 5) (RSK-like protein kinase) (RLSK)
          Length = 802

 Score =  136 bits (343), Expect = 4e-32
 Identities = 95/268 (35%), Positives = 141/268 (52%), Gaps = 38/268 (14%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLC--HPHIIRLYQVMETERMIYLVTE 71
           +++ Q  A+KII K    E N +K   E+  +K LC  HP+I++L++V   +   +LV E
Sbjct: 446 KKSNQAFAVKIISKRM--EANTQK---EITALK-LCEGHPNIVKLHEVFHDQLHTFLVME 499

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128
             +GGE+F+ +      +E EA    +++V+AV   H   +VHRDLK ENLL    + NL
Sbjct: 500 LLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNL 559

Query: 129 NIKIADFGFSNLFTP-GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187
            IKI DFGF+ L  P  Q LKT C +  YAAPEL     YD    D+WSLGV+LY ++ G
Sbjct: 560 EIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYD-ESCDLWSLGVILYTMLSG 618

Query: 188 ALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSI---------AECEH 238
            +PF                      ++     E+ K++K G  S           E + 
Sbjct: 619 QVPFQSHDRS----------------LTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 662

Query: 239 LIRHMLVLDPNKRLSMEQICKHKWMKLG 266
           LI+ +L +DPNKRL M  +  ++W++ G
Sbjct: 663 LIQGLLTVDPNKRLKMSGLRYNEWLQDG 690



 Score =  114 bits (284), Expect = 3e-25
 Identities = 77/248 (31%), Positives = 130/248 (52%), Gaps = 28/248 (11%)

Query: 15  ETKQLVAIKIIDKTQLDEE--NLKKIFREVQIMKMLCH-PHIIRLYQVMETERMIYLVTE 71
           +T +L A+K++ K  + ++    +    E Q+++ +   P ++ L+   +TE  ++L+ +
Sbjct: 73  DTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILD 132

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
           Y +GGE+F HL    R  E E +    +IV A+   H   I++RD+K EN+LLD+N ++ 
Sbjct: 133 YINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVV 192

Query: 132 IADFGFSNLFTPGQLLK--TWCGSPPYAAPELFEGKEYDGPK-VDIWSLGVVLYVLVCGA 188
           + DFG S  F   +  +  ++CG+  Y AP++  G +    K VD WSLGV++Y L+ GA
Sbjct: 193 LTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGA 252

Query: 189 LPFDGSTLQNLRA----RVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244
            PF     +N +A    R+L  +   P  MS                  A  + LI+ +L
Sbjct: 253 SPFTVDGEKNSQAEISRRILKSEPPYPQEMS------------------ALAKDLIQRLL 294

Query: 245 VLDPNKRL 252
           + DP KRL
Sbjct: 295 MKDPKKRL 302



>gi|6136124|sp|O75385|ULK1_HUMAN   Serine/threonine-protein kinase ULK1 (Unc-51-like kinase 1)
          Length = 1050

 Score =  136 bits (343), Expect = 4e-32
 Identities = 77/201 (38%), Positives = 113/201 (56%), Gaps = 11/201 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K I+K  L +     + +E++I+K L H +I+ LY   E    +YLV EY +GG++ 
Sbjct: 43  VAVKCINKKNLAKSQTL-LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLA 101

Query: 80  DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD------ANLN---I 130
           D+L A   ++E   R   +QI  A+   H + I+HRDLK +N+LL       AN N   +
Sbjct: 102 DYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRV 161

Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           KIADFGF+       +  T CGSP Y APE+   + YDG K D+WS+G ++Y  + G  P
Sbjct: 162 KIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKAP 220

Query: 191 FDGSTLQNLRARVLSGKFRIP 211
           F  S+ Q+LR      K  +P
Sbjct: 221 FQASSPQDLRLFYEKNKTLVP 241



>gi|6225242|sp|O15075|DCAK1_HUMAN   Serine/threonine-protein kinase DCAMKL1 (Doublecortin-like and CAM
           kinase-like 1)
          Length = 740

 Score =  135 bits (340), Expect = 1e-31
 Identities = 98/328 (29%), Positives = 163/328 (49%), Gaps = 29/328 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           + T +  A+KII K++   +    I  EV I++ + HP+I+ L + M+    +YLV E  
Sbjct: 410 RSTAREYALKIIKKSKCRGKE-HMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELV 468

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLN 129
            GG++FD + +  +  E++A      + +A+ + H  NIVHRD+K ENLL+    D + +
Sbjct: 469 KGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKS 528

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           +K+ DFG + +      L T CG+P Y APE+     Y G KVDIW+ GV+ Y+L+CG  
Sbjct: 529 LKLGDFGLATIVDGP--LYTVCGTPTYVAPEIIAETGY-GLKVDIWAAGVITYILLCGFP 585

Query: 190 PFDGS--TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247
           PF GS    + L  ++L G+   P        P  D    +        + LI  ML++D
Sbjct: 586 PFRGSGDDQEVLFDQILMGQVDFP-------SPYWDNVSDS-------AKELITMMLLVD 631

Query: 248 PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV---LLAMEDMGL 304
            ++R S  Q+ +H W+   D  P  +  ++   ++K+     P        +  +    L
Sbjct: 632 VDQRFSAVQVLEHPWVN-DDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTAL 690

Query: 305 DKE-QTLQPDGTLNLDSDEGEEPSPEAL 331
           DKE Q  +     ++ S    +P+P  L
Sbjct: 691 DKERQVFRRRRNQDVRSRYKAQPAPPEL 718



>gi|1170703|sp|P31751|AKT2_HUMAN   RAC-beta serine/threonine-protein kinase (RAC-PK-beta) (Protein
           kinase Akt-2) (Protein kinase B, beta) (PKB beta)
          Length = 481

 Score =  133 bits (335), Expect = 4e-31
 Identities = 90/303 (29%), Positives = 148/303 (48%), Gaps = 37/303 (12%)

Query: 16  TKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T +  A+KI+ K  +  ++ +     E ++++   HP +  L    +T   +  V EYA+
Sbjct: 174 TGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYAN 233

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GGE+F HL       E+ AR    +IV+A+ + H R++V+RD+K ENL+LD + +IKI D
Sbjct: 234 GGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITD 293

Query: 135 FGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           FG      + G  +KT+CG+P Y APE+ E  +Y G  VD W LGVV+Y ++CG LPF  
Sbjct: 294 FGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYN 352

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252
              + L   +L  + R P  +S                   E + L+  +L  DP +RL 
Sbjct: 353 QDHERLFELILMEEIRFPRTLS------------------PEAKSLLAGLLKKDPKQRLG 394

Query: 253 ----SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ 308
                 +++ +H++            L    Q + +++ + P    V   ++    D E 
Sbjct: 395 GGPSDAKEVMEHRFF-----------LSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443

Query: 309 TLQ 311
           T Q
Sbjct: 444 TAQ 446



>gi|125210|sp|P22694|KAPCB_HUMAN   cAMP-dependent protein kinase, beta-catalytic subunit (PKA C-beta)
          Length = 351

 Score =  132 bits (331), Expect = 1e-30
 Identities = 84/260 (32%), Positives = 132/260 (50%), Gaps = 31/260 (11%)

Query: 16  TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T+Q  A+KI+DK ++ + + ++    E +I++ +  P ++RL    +    +Y+V EY  
Sbjct: 66  TEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVP 125

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GGE+F HL   GR +E  AR    QIV    + H  ++++RDLK ENLL+D    I++ D
Sbjct: 126 GGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTD 185

Query: 135 FGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           FGF+         +TW  CG+P Y APE+   K Y+   VD W+LGV++Y +  G  PF 
Sbjct: 186 FGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFF 240

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
                 +  +++SGK R P   S+ L                  + L+R++L +D  KR 
Sbjct: 241 ADQPIQIYEKIVSGKVRFPSHFSSDL------------------KDLLRNLLQVDLTKRF 282

Query: 253 -----SMEQICKHKWMKLGD 267
                 +  I  HKW    D
Sbjct: 283 GNLKNGVSDIKTHKWFATTD 302



>gi|38605084|sp|Q9UIK4|DAPK2_HUMAN   Death-associated protein kinase 2 (DAP kinase 2) (DAP-kinase
           related protein 1) (DRP-1)
          Length = 370

 Score =  131 bits (330), Expect = 1e-30
 Identities = 84/234 (35%), Positives = 126/234 (53%), Gaps = 23/234 (9%)

Query: 36  KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARR 95
           ++I REV I++ + H ++I L+ V E    + L+ E  SGGE+FD L     ++E+EA  
Sbjct: 69  EEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATS 128

Query: 96  KFKQIVTAVYFCHCRNIVHRDLKAEN-LLLDANL---NIKIADFGFSNLFTPGQLLKTWC 151
             KQI+  V + H + I H DLK EN +LLD N+   +IK+ DFG ++    G   K   
Sbjct: 129 FIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIF 188

Query: 152 GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARV--LSGKFR 209
           G+P + APE+    E  G + D+WS+GV+ Y+L+ GA PF G T Q   A +  +S  F 
Sbjct: 189 GTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFD 247

Query: 210 IPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263
             FF  T    EL K               IR +LV +  KRL++++  +H W+
Sbjct: 248 EEFFSQTS---ELAK-------------DFIRKLLVKETRKRLTIQEALRHPWI 285



>gi|11133131|sp|Q9UK32|KS6A6_HUMAN   Ribosomal protein S6 kinase alpha 6 (S6K-alpha 6) (90 kDa ribosomal
           protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4)
           (RSK-4) (pp90RSK4)
          Length = 745

 Score =  131 bits (329), Expect = 2e-30
 Identities = 92/264 (34%), Positives = 135/264 (51%), Gaps = 28/264 (10%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T    A+KIIDK++ D     +I     +M+   HP+II L  V +  R +YLVT+   G
Sbjct: 448 TNMEFAVKIIDKSKRDPSEEIEI-----LMRYGQHPNIITLKDVFDDGRYVYLVTDLMKG 502

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANL---NIK 131
           GE+ D ++     +E+EA      I   V + HC+ +VHRDLK  N+L +D +    +I+
Sbjct: 503 GELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIR 562

Query: 132 IADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           I DFGF+  L     LL T C +  + APE+   + YD    DIWSLGV+ Y ++ G  P
Sbjct: 563 ICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDA-ACDIWSLGVLFYTMLAGYTP 621

Query: 191 F---DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247
           F      T + +  R+ +GKF     +S G    +    K           L+ HML +D
Sbjct: 622 FANGPNDTPEEILLRIGNGKFS----LSGGNWDNISDGAK----------DLLSHMLHMD 667

Query: 248 PNKRLSMEQICKHKWMKLGDADPN 271
           P++R + EQI KH W+   D  PN
Sbjct: 668 PHQRYTAEQILKHSWITHRDQLPN 691



 Score =  113 bits (283), Expect = 4e-25
 Identities = 70/230 (30%), Positives = 115/230 (50%), Gaps = 5/230 (2%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           QL A+K++ K  L   +  +   E  I+  + HP I++L+   +TE  +YL+ ++  GG+
Sbjct: 100 QLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD 159

Query: 78  IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           +F  L       E++ +    ++  A+   H   IV+RDLK EN+LLD   +IK+ DFG 
Sbjct: 160 VFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGL 219

Query: 138 S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196
           S       +   ++CG+  Y APE+   + +     D WS GV+++ ++ G LPF G   
Sbjct: 220 SKESVDQEKKAYSFCGTVEYMAPEVVNRRGH-SQSADWWSYGVLMFEMLTGTLPFQGKDR 278

Query: 197 QNLRARVLSGKFRIPFFMST---GLVPELDKRLKAGCLSIAECEHLIRHM 243
                 +L  K  +P F+S     L+  L KR  A  L     E + RH+
Sbjct: 279 NETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHL 328



>gi|59797954|sp|Q8N568|DCAK2_HUMAN   Serine/threonine-protein kinase DCAMKL2 (Doublecortin-like and CAM
           kinase-like 2)
          Length = 766

 Score =  131 bits (329), Expect = 2e-30
 Identities = 86/257 (33%), Positives = 136/257 (52%), Gaps = 26/257 (10%)

Query: 14  QETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           + T +  A+KIIDK +   +E+L  I  EV I++ + HP+II L + MET   ++LV E 
Sbjct: 414 RSTGKEFALKIIDKAKCCGKEHL--IENEVSILRRVKHPNIIMLVEEMETATELFLVMEL 471

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANL 128
             GG++FD + +  +  E++       +  A+ + H  +IVHRD+K ENLL+    D   
Sbjct: 472 VKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTK 531

Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188
           ++K+ DFG + +      L T CG+P Y APE+     Y G KVDIW+ GV+ Y+L+CG 
Sbjct: 532 SLKLGDFGLATVVEGP--LYTVCGTPTYVAPEIIAETGY-GLKVDIWAAGVITYILLCGF 588

Query: 189 LPF--DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246
            PF  + +  ++L  ++L+GK   P        P  D    +        + LI  ML +
Sbjct: 589 PPFRSENNLQEDLFDQILAGKLEFP-------APYWDNITDS-------AKELISQMLQV 634

Query: 247 DPNKRLSMEQICKHKWM 263
           +   R +  QI  H W+
Sbjct: 635 NVEARCTAGQILSHPWV 651



>gi|12643943|sp|Q9Y243|AKT3_HUMAN   RAC-gamma serine/threonine-protein kinase (RAC-PK-gamma) (Protein
           kinase Akt-3) (Protein kinase B, gamma) (PKB gamma)
           (STK-2)
          Length = 479

 Score =  130 bits (328), Expect = 2e-30
 Identities = 90/298 (30%), Positives = 142/298 (47%), Gaps = 37/298 (12%)

Query: 21  AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           A+KI+ K  +  ++ +     E +++K   HP +  L    +T+  +  V EY +GGE+F
Sbjct: 175 AMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 234

Query: 80  DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S 138
            HL      +E   R    +IV+A+ + H   IV+RDLK ENL+LD + +IKI DFG   
Sbjct: 235 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK 294

Query: 139 NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 198
              T    +KT+CG+P Y APE+ E  +Y G  VD W LGVV+Y ++CG LPF     + 
Sbjct: 295 EGITDAATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEK 353

Query: 199 LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL-----S 253
           L   +L    + P  +S                  ++ + L+  +L+ DPNKRL      
Sbjct: 354 LFELILMEDIKFPRTLS------------------SDAKSLLSGLLIKDPNKRLGGGPDD 395

Query: 254 MEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQ 311
            ++I +H +                 Q + +++ V P    V    +    D+E T Q
Sbjct: 396 AKEIMRHSFFS-----------GVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQ 442



>gi|14423930|sp|Q9UEE5|ST17A_HUMAN   Serine/threonine-protein kinase 17A (DAP kinase-related
           apoptosis-inducing protein kinase 1)
          Length = 414

 Score =  130 bits (328), Expect = 2e-30
 Identities = 91/285 (31%), Positives = 143/285 (50%), Gaps = 28/285 (9%)

Query: 21  AIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           A K + K +  ++   +I  E+ ++++   +P +I L++V ET   + LV EYA+GGEIF
Sbjct: 88  AAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIF 147

Query: 80  DHLVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKIAD 134
           D  VA    A  EK+ +R  +QI+  V+F H R++VH DLK +N+LL +     +IKI D
Sbjct: 148 DQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVD 207

Query: 135 FGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFD 192
           FG S +    + L+   G+P Y APE+     YD      D+WS+GV+ YV++ G  PF 
Sbjct: 208 FGLSRILKNSEELREIMGTPEYVAPEIL---SYDPISMATDMWSIGVLTYVMLTGISPFL 264

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
           G+  Q     +          M+     E    L    +        IR +LV  P  R 
Sbjct: 265 GNDKQETFLNISQ--------MNLSYSEEEFDVLSESAVD------FIRTLLVKKPEDRA 310

Query: 253 SMEQICKHKWMKLGD-ADPNF--DRLIAECQQLKEERQVDPLNED 294
           + E+  KH W+      +P+F  ++ + E   L+E   V  +N D
Sbjct: 311 TAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSD 355



>gi|1709648|sp|P51817|PRKX_HUMAN   Serine/threonine-protein kinase PRKX (Protein kinase PKX1)
          Length = 358

 Score =  130 bits (326), Expect = 4e-30
 Identities = 81/261 (31%), Positives = 134/261 (51%), Gaps = 35/261 (13%)

Query: 17  KQLVAIKII---DKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           K   A+K++   D  +L +E  + +  E  ++K + HP +IRL+     ER +Y++ EY 
Sbjct: 72  KHFFALKVMSIPDVIRLKQE--QHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYV 129

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
            GGE+F +L   GR +         +I+ A+ + H + IV+RDLK EN+LLD + +IK+ 
Sbjct: 130 PGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLT 189

Query: 134 DFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           DFGF+         +TW  CG+P Y APE+ + K + G  VD W+LG++++ ++ G  PF
Sbjct: 190 DFGFAKKLVD----RTWTLCGTPEYLAPEVIQSKGH-GRAVDWWALGILIFEMLSGFPPF 244

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
                  +  ++L+GK   P          LD  +K           LI+ +LV+D  +R
Sbjct: 245 FDDNPFGIYQKILAGKIDFP--------RHLDFHVK----------DLIKKLLVVDRTRR 286

Query: 252 L-----SMEQICKHKWMKLGD 267
           L         +  H+W +  D
Sbjct: 287 LGNMKNGANDVKHHRWFRSVD 307



>gi|1346538|sp|P49137|MAPK2_HUMAN   MAP kinase-activated protein kinase 2 (MAPK-activated protein
           kinase 2) (MAPKAP kinase 2) (MAPKAPK-2)
          Length = 400

 Score =  129 bits (325), Expect = 5e-30
 Identities = 94/320 (29%), Positives = 160/320 (50%), Gaps = 39/320 (12%)

Query: 4   VKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH-PHIIRLYQVMET 62
           + G ++Q F + T++  A+K++       ++  K  REV++       PHI+R+  V E 
Sbjct: 74  INGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIVDVYEN 126

Query: 63  ----ERMIYLVTEYASGGEIFDHLVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRD 116
                + + +V E   GGE+F  +   G  A  E+EA    K I  A+ + H  NI HRD
Sbjct: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 186

Query: 117 LKAENLLLDA---NLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173
           +K ENLL  +   N  +K+ DFGF+   T    L T C +P Y APE+   ++YD    D
Sbjct: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD-KSCD 245

Query: 174 IWSLGVVLYVLVCGALPFDG----STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAG 229
           +WSLGV++Y+L+CG  PF      +    ++ R+  G++  P        PE  +  +  
Sbjct: 246 MWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP-------NPEWSEVSE-- 296

Query: 230 CLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQ-V 288
                E + LIR++L  +P +R+++ +   H W+      P     +   + LKE+++  
Sbjct: 297 -----EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP--LHTSRVLKEDKERW 349

Query: 289 DPLNEDVLLAMEDMGLDKEQ 308
           + + E++  A+  M +D EQ
Sbjct: 350 EDVKEEMTSALATMRVDYEQ 369



>gi|33860173|sp|P22612|KAPCG_HUMAN   cAMP-dependent protein kinase, gamma-catalytic subunit (PKA
           C-gamma)
          Length = 351

 Score =  129 bits (325), Expect = 5e-30
 Identities = 83/257 (32%), Positives = 133/257 (51%), Gaps = 31/257 (12%)

Query: 14  QETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           QET    A+KI++K ++ + + ++ I  E +I++ +  P +++L    +    +YLV EY
Sbjct: 64  QETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEY 123

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
             GGE+F  L   GR +E  A     Q+V AV + H  +++HRDLK ENLL+D    +++
Sbjct: 124 VPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQV 183

Query: 133 ADFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
            DFGF+         +TW  CG+P Y APE+   K Y+   VD W+LGV++Y +  G  P
Sbjct: 184 TDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAVGFPP 238

Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
           F       +  +++SG+ R P  +S+ L                  +HL+R +L +D  K
Sbjct: 239 FYADQPIQIYEKIVSGRVRFPSKLSSDL------------------KHLLRSLLQVDLTK 280

Query: 251 RL-----SMEQICKHKW 262
           R       +  I  HKW
Sbjct: 281 RFGNLRNGVGDIKNHKW 297



>gi|125205|sp|P17612|KAPCA_HUMAN   cAMP-dependent protein kinase, alpha-catalytic subunit (PKA
           C-alpha)
          Length = 351

 Score =  128 bits (322), Expect = 1e-29
 Identities = 83/262 (31%), Positives = 132/262 (50%), Gaps = 31/262 (11%)

Query: 14  QETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           +ET    A+KI+DK ++ + + ++    E +I++ +  P +++L    +    +Y+V EY
Sbjct: 64  KETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEY 123

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
             GGE+F HL   GR +E  AR    QIV    + H  ++++RDLK ENLL+D    I++
Sbjct: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQV 183

Query: 133 ADFGFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
            DFGF+         +TW  CG+P Y APE+   K Y+   VD W+LGV++Y +  G  P
Sbjct: 184 TDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPP 238

Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
           F       +  +++SGK R P   S+ L                  + L+R++L +D  K
Sbjct: 239 FFADQPIQIYEKIVSGKVRFPSHFSSDL------------------KDLLRNLLQVDLTK 280

Query: 251 RL-----SMEQICKHKWMKLGD 267
           R       +  I  HKW    D
Sbjct: 281 RFGNLKNGVNDIKNHKWFATTD 302



>gi|20141585|sp|Q05513|KPCZ_HUMAN   Protein kinase C, zeta type (nPKC-zeta)
          Length = 592

 Score =  127 bits (320), Expect = 2e-29
 Identities = 91/326 (27%), Positives = 157/326 (48%), Gaps = 49/326 (15%)

Query: 13  LQETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVT 70
           L++  Q+ A+K++ K  + D+E++  +  E  + +    +P ++ L+   +T   ++LV 
Sbjct: 271 LKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVI 330

Query: 71  EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130
           EY +GG++  H+    ++ E+ AR    +I  A+ F H R I++RDLK +N+LLDA+ +I
Sbjct: 331 EYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHI 390

Query: 131 KIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           K+ D+G       PG    T+CG+P Y APE+  G+EY G  VD W+LGV+++ ++ G  
Sbjct: 391 KLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY-GFSVDWWALGVLMFEMMAGRS 449

Query: 190 PF-------DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRH 242
           PF       D +T   L   +L    RIP F+S                   +  H+++ 
Sbjct: 450 PFDIITDNPDMNTEDYLFQVILEKPIRIPRFLS------------------VKASHVLKG 491

Query: 243 MLVLDPNKRL------SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVL 296
            L  DP +RL          I  H + +  D D            L++++ + P    + 
Sbjct: 492 FLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWD-----------LLEKKQALPPFQPQI- 539

Query: 297 LAMEDMGLDKEQTLQPDGTLNLDSDE 322
              +D GLD   T      + L  D+
Sbjct: 540 --TDDYGLDNFDTQFTSEPVQLTPDD 563



>gi|37999483|sp|O75676|KS6A4_HUMAN   Ribosomal protein S6 kinase alpha 4 (Nuclear mitogen-and
           stress-activated protein kinase-2) (90 kDa ribosomal
           protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB)
          Length = 772

 Score =  126 bits (317), Expect = 5e-29
 Identities = 88/269 (32%), Positives = 141/269 (52%), Gaps = 34/269 (12%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKML-CHPHIIRLYQVMETERMIYLVTEY 72
           +++ Q  A+KI+ +    E N +   REV  +++   HP+++ L++V   +   YLV E 
Sbjct: 431 RQSGQEFAVKILSRRL--EANTQ---REVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL 485

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCR-NIVHRDLKAENLLL---DANL 128
             GGE+ +H+      +E EA +  + +V+AV F H    +VHRDLK EN+L        
Sbjct: 486 LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGA 545

Query: 129 NIKIADFGFSNL--FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC 186
            +KI DFGF+ L   +PG  ++T C +  YAAPEL   + YD    D+WSLGV+LY+++ 
Sbjct: 546 PVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD-ESCDLWSLGVILYMMLS 604

Query: 187 GALPFDGSTLQ-------NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239
           G +PF G++ Q        +  ++  G+F             LD     G     E + L
Sbjct: 605 GQVPFQGASGQGGQSQAAEIMCKIREGRF------------SLDGEAWQGVSE--EAKEL 650

Query: 240 IRHMLVLDPNKRLSMEQICKHKWMKLGDA 268
           +R +L +DP KRL +E +    W++ G A
Sbjct: 651 VRGLLTVDPAKRLKLEGLRGSSWLQDGSA 679



 Score =  110 bits (275), Expect = 3e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 23/242 (9%)

Query: 18  QLVAIKIIDKTQLDE--ENLKKIFREVQIMKMLCH-PHIIRLYQVMETERMIYLVTEYAS 74
           +L A+K++ K  L +  +  +    E  +++++   P ++ L+   +T+  ++L+ +Y S
Sbjct: 60  KLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVS 119

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GGE+F HL       E E R    +IV A+   H   I++RDLK EN+LLD+  +I + D
Sbjct: 120 GGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTD 179

Query: 135 FGFSNLFTPGQLLKT--WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           FG S  F   +  +T  +CG+  Y APE+   K   G  VD WSLG++L+ L+ GA PF 
Sbjct: 180 FGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFT 239

Query: 193 GSTLQNLRARVLSG--KFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
               +N +A V     K   PF    G V                 + L++ +L  DP K
Sbjct: 240 LEGERNTQAEVSRRILKCSPPFPPRIGPV----------------AQDLLQRLLCKDPKK 283

Query: 251 RL 252
           RL
Sbjct: 284 RL 285



>gi|60391226|sp|P31749|AKT1_HUMAN   RAC-alpha serine/threonine-protein kinase (RAC-PK-alpha) (Protein
           kinase B) (PKB) (C-AKT)
          Length = 480

 Score =  126 bits (316), Expect = 6e-29
 Identities = 95/318 (29%), Positives = 151/318 (47%), Gaps = 38/318 (11%)

Query: 16  TKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T +  A+KI+ K  +  ++ +     E ++++   HP +  L    +T   +  V EYA+
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYAN 231

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC-RNIVHRDLKAENLLLDANLNIKIA 133
           GGE+F HL      +E  AR    +IV+A+ + H  +N+V+RDLK ENL+LD + +IKI 
Sbjct: 232 GGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKIT 291

Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           DFG        G  +KT+CG+P Y APE+ E  +Y G  VD W LGVV+Y ++CG LPF 
Sbjct: 292 DFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFY 350

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
               + L   +L  + R P  +                    E + L+  +L  DP +RL
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLG------------------PEAKSLLSGLLKKDPKQRL 392

Query: 253 -----SMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKE 307
                  ++I +H++         F  ++   Q + E++   P    V    +    D+E
Sbjct: 393 GGGSEDAKEIMQHRF---------FAGIV--WQHVYEKKLSPPFKPQVTSETDTRYFDEE 441

Query: 308 QTLQPDGTLNLDSDEGEE 325
            T Q       D D+  E
Sbjct: 442 FTAQMITITPPDQDDSME 459



>gi|27735175|sp|O14936|CSKP_HUMAN   Peripheral plasma membrane protein CASK (hCASK)
           (Calcium/calmodulin-dependent serine protein kinase)
           (Lin-2 homolog)
          Length = 926

 Score =  126 bits (316), Expect = 6e-29
 Identities = 92/300 (30%), Positives = 150/300 (50%), Gaps = 33/300 (11%)

Query: 14  QETKQLVAIKIIDKTQ------LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY 67
           +ET Q  A+KI+D  +      L  E+LK   RE  I  ML HPHI+ L +   ++ M+Y
Sbjct: 32  RETGQQFAVKIVDVAKFTSSPGLSTEDLK---REASICHMLKHPHIVELLETYSSDGMLY 88

Query: 68  LVTEYASGGEIFDHLVAHGR----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123
           +V E+  G ++   +V         +E  A    +QI+ A+ +CH  NI+HRD+K   +L
Sbjct: 89  MVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVL 148

Query: 124 LDANLN---IKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV 179
           L +  N   +K+  FG +  L   G +     G+P + APE+ + + Y G  VD+W  GV
Sbjct: 149 LASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPY-GKPVDVWGCGV 207

Query: 180 VLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239
           +L++L+ G LPF G T + L   ++ GK++    M+      + +  K           L
Sbjct: 208 ILFILLSGCLPFYG-TKERLFEGIIKGKYK----MNPRQWSHISESAK----------DL 252

Query: 240 IRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAM 299
           +R ML+LDP +R+++ +   H W+K  D       L    +QL++      L   VL A+
Sbjct: 253 VRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAV 312



>gi|6226833|sp|Q13237|KGP2_HUMAN   cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II
           cGMP-dependent protein kinase)
          Length = 762

 Score =  124 bits (311), Expect = 2e-28
 Identities = 78/249 (31%), Positives = 124/249 (49%), Gaps = 23/249 (9%)

Query: 21  AIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           A+K I K  + D +  + ++ E +I++ LC P I++LY+  +  + +Y++ E   GGE++
Sbjct: 480 AMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELW 539

Query: 80  DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN 139
             L   G   E  ++     +  A  + H   I++RDLK ENL+LDA   +K+ DFGF+ 
Sbjct: 540 SILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAK 599

Query: 140 LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL 199
               GQ   T+CG+P Y APE+   K +D   VD WSLG+++Y L+ G  PF G      
Sbjct: 600 KIGSGQKTWTFCGTPEYVAPEVILNKGHDF-SVDFWSLGILVYELLTGNPPFSGVDQMMT 658

Query: 200 RARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL-----SM 254
              +L G  ++ F       P                E LIR +   +P +RL      +
Sbjct: 659 YNLILKGIEKMDFPRKITRRP----------------EDLIRRLCRQNPTERLGNLKNGI 702

Query: 255 EQICKHKWM 263
             I KH+W+
Sbjct: 703 NDIKKHRWL 711



>gi|1730070|sp|P51812|KS6A3_HUMAN   Ribosomal protein S6 kinase alpha 3 (S6K-alpha 3) (90 kDa ribosomal
           protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2)
           (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1)
           (ISPK-1)
          Length = 740

 Score =  124 bits (311), Expect = 2e-28
 Identities = 90/266 (33%), Positives = 136/266 (51%), Gaps = 30/266 (11%)

Query: 16  TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T    A+KIIDK++ D  E ++ + R  Q      HP+II L  V +  + +Y+VTE   
Sbjct: 444 TNMEFAVKIIDKSKRDPTEEIEILLRYGQ------HPNIITLKDVYDDGKYVYVVTELMK 497

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANLN---I 130
           GGE+ D ++     +E+EA      I   V + H + +VHRDLK  N+L +D + N   I
Sbjct: 498 GGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESI 557

Query: 131 KIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           +I DFGF+  L     LL T C +  + APE+ + + YD    DIWSLGV+LY ++ G  
Sbjct: 558 RICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGVLLYTMLTGYT 616

Query: 190 PF---DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246
           PF      T + + AR+ SGKF     +S G    +    K           L+  ML +
Sbjct: 617 PFANGPDDTPEEILARIGSGKFS----LSGGYWNSVSDTAK----------DLVSKMLHV 662

Query: 247 DPNKRLSMEQICKHKWMKLGDADPNF 272
           DP++RL+   + +H W+   D  P +
Sbjct: 663 DPHQRLTAALVLRHPWIVHWDQLPQY 688



 Score =  114 bits (285), Expect = 2e-25
 Identities = 72/268 (26%), Positives = 128/268 (47%), Gaps = 25/268 (9%)

Query: 15  ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           + +QL A+K++ K  L   +  +   E  I+  + HP I++L+   +TE  +YL+ ++  
Sbjct: 92  DARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLR 151

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GG++F  L       E++ +    ++  A+   H   I++RDLK EN+LLD   +IK+ D
Sbjct: 152 GGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTD 211

Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           FG S       +   ++CG+  Y APE+   + +     D WS GV+++ ++ G LPF G
Sbjct: 212 FGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGTLPFQG 270

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252
              +     +L  K  +P F+S                   E + L+R +   +P  RL 
Sbjct: 271 KDRKETMTMILKAKLGMPQFLS------------------PEAQSLLRMLFKRNPANRLG 312

Query: 253 ----SMEQICKHKWMKLGDADPNFDRLI 276
                +E+I +H +    D +  + R I
Sbjct: 313 AGPDGVEEIKRHSFFSTIDWNKLYRREI 340



>gi|51338822|sp|Q9H4B4|PLK3_HUMAN   Serine/threonine-protein kinase PLK3 (Polo-like kinase 3) (PLK-3)
           (Cytokine-inducible serine/threonine-protein kinase)
           (FGF-inducible kinase) (Proliferation-related kinase)
          Length = 646

 Score =  123 bits (309), Expect = 4e-28
 Identities = 76/254 (29%), Positives = 126/254 (49%), Gaps = 21/254 (8%)

Query: 15  ETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           ET    A+K+I ++++ + + + KI  E+++ + L H HI+R     E    IY+  E  
Sbjct: 83  ETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELC 142

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
           S   +     A   + E E R   +QI++ + + H R I+HRDLK  N  +  N+ +K+ 
Sbjct: 143 SRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVG 202

Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           DFG  + L  P Q  KT CG+P Y APE+   ++  GP+ D+WSLG V+Y L+CG+ PF+
Sbjct: 203 DFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLCGSPPFE 261

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
            + L+     +    + +P  +S                       L+  +L   P  R 
Sbjct: 262 TADLKETYRCIKQVHYTLPASLS------------------LPARQLLAAILRASPRDRP 303

Query: 253 SMEQICKHKWMKLG 266
           S++QI +H +   G
Sbjct: 304 SIDQILRHDFFTKG 317



>gi|1170688|sp|P41743|KPCI_HUMAN   Protein kinase C, iota type (nPKC-iota) (Atypical protein kinase
           C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota)
          Length = 587

 Score =  123 bits (308), Expect = 5e-28
 Identities = 62/183 (33%), Positives = 111/183 (60%), Gaps = 4/183 (2%)

Query: 13  LQETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVT 70
           L++T ++ A+K++ K  + D+E++  +  E  + +    HP ++ L+   +TE  ++ V 
Sbjct: 264 LKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVI 323

Query: 71  EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130
           EY +GG++  H+    ++ E+ AR    +I  A+ + H R I++RDLK +N+LLD+  +I
Sbjct: 324 EYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHI 383

Query: 131 KIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           K+ D+G       PG    T+CG+P Y APE+  G++Y G  VD W+LGV+++ ++ G  
Sbjct: 384 KLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY-GFSVDWWALGVLMFEMMAGRS 442

Query: 190 PFD 192
           PFD
Sbjct: 443 PFD 445



>gi|41017453|sp|O43930|PRKY_HUMAN   Serine/threonine-protein kinase PRKY
          Length = 277

 Score =  122 bits (307), Expect = 7e-28
 Identities = 67/208 (32%), Positives = 113/208 (54%), Gaps = 12/208 (5%)

Query: 17  KQLVAIKIIDKTQLDEENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           K   A+K++    +     ++ +  E  ++K + HP +IRL+     ER +Y++ EY  G
Sbjct: 72  KHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPG 131

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GE+F +L   G  +         +I+ A+ + H + IV+RDLK EN+LLD + +IK+ DF
Sbjct: 132 GELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDF 191

Query: 136 GFSNLFTPGQLLKTW--CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           GF+         +TW  CG+P Y APE+ + K + G  VD W+LG++++ ++ G  PF  
Sbjct: 192 GFAKKLVD----RTWTLCGTPEYLAPEVIQSKGH-GRAVDWWALGILIFEMLSGFPPFFD 246

Query: 194 STLQNLRARVLSGKFRIP----FFMSTG 217
                +  ++L+GK   P    F + TG
Sbjct: 247 DNPFGIYQKILAGKLYFPRHLDFHVKTG 274



>gi|20178306|sp|Q15418|KS6A1_HUMAN   Ribosomal protein S6 kinase alpha 1 (S6K-alpha 1) (90 kDa ribosomal
           protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1)
           (RSK-1) (pp90RSK1)
          Length = 735

 Score =  122 bits (307), Expect = 7e-28
 Identities = 88/264 (33%), Positives = 137/264 (51%), Gaps = 30/264 (11%)

Query: 16  TKQLVAIKIIDKTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T    A+K+IDK++ D  E ++ + R  Q      HP+II L  V +  + +YLVTE   
Sbjct: 440 TNMEYAVKVIDKSKRDPSEEIEILLRYGQ------HPNIITLKDVYDDGKHVYLVTELMR 493

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL-LDANLN---I 130
           GGE+ D ++     +E+EA      I   V + H + +VHRDLK  N+L +D + N   +
Sbjct: 494 GGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECL 553

Query: 131 KIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           +I DFGF+  L     LL T C +  + APE+ + + YD    DIWSLG++LY ++ G  
Sbjct: 554 RICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD-EGCDIWSLGILLYTMLAGYT 612

Query: 190 PF---DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246
           PF      T + +  R+ SGKF     +S G    + +  K           L+  ML +
Sbjct: 613 PFANGPSDTPEEILTRIGSGKFT----LSGGNWNTVSETAK----------DLVSKMLHV 658

Query: 247 DPNKRLSMEQICKHKWMKLGDADP 270
           DP++RL+ +Q+ +H W+   D  P
Sbjct: 659 DPHQRLTAKQVLQHPWVTQKDKLP 682



 Score =  111 bits (277), Expect = 2e-24
 Identities = 70/244 (28%), Positives = 122/244 (50%), Gaps = 9/244 (3%)

Query: 15  ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           ++  L A+K++ K  L   +  +   E  I+  + HP +++L+   +TE  +YL+ ++  
Sbjct: 86  DSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLR 145

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GG++F  L       E++ +    ++   +   H   I++RDLK EN+LLD   +IK+ D
Sbjct: 146 GGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTD 205

Query: 135 FGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           FG S       +   ++CG+  Y APE+   ++      D WS GV+++ ++ G+LPF G
Sbjct: 206 FGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQG 264

Query: 194 STLQNLRARVLSGKFRIPFFMST---GLVPELDKRLKAGCLSIAE--CEHLIRHML--VL 246
              +     +L  K  +P F+ST    L+  L KR  A  L       E + RH+    +
Sbjct: 265 KDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 324

Query: 247 DPNK 250
           D NK
Sbjct: 325 DWNK 328



>gi|22096374|sp|Q9NYY3|PLK2_HUMAN   Serine/threonine-protein kinase PLK2 (Polo-like kinase 1) (PLK-2)
           (Serine/threonine-protein kinase SNK) (Serum inducible
           kinase)
          Length = 685

 Score =  122 bits (306), Expect = 9e-28
 Identities = 75/264 (28%), Positives = 135/264 (51%), Gaps = 24/264 (9%)

Query: 18  QLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           ++ A KII  +++ + + + KI +E+++ ++L H H+++ Y   E +  IY++ EY S  
Sbjct: 106 KVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRR 165

Query: 77  EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136
            +   L A   + E E R   +QIV+ + + H + I+HRDLK  N  ++  + +K+ DFG
Sbjct: 166 SMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFG 225

Query: 137 FSNLFTP-GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGST 195
            +    P     +T CG+P Y +PE+   K+  G + DIW+LG V+Y ++ G  PF+ + 
Sbjct: 226 LAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIWALGCVMYTMLLGRPPFETTN 284

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255
           L+     +   ++ +P  +                  +A  +HLI  ML  +P  R S++
Sbjct: 285 LKETYRCIREARYTMPSSL------------------LAPAKHLIASMLSKNPEDRPSLD 326

Query: 256 QICKHKWMKLGDADPNFDRLIAEC 279
            I +H +   G      DRL + C
Sbjct: 327 DIIRHDFFLQGFTP---DRLSSSC 347



>gi|6166243|sp|Q15349|KS6A2_HUMAN   Ribosomal protein S6 kinase alpha 2 (S6K-alpha 2) (90 kDa ribosomal
           protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3)
           (RSK-3) (pp90RSK3)
          Length = 733

 Score =  121 bits (303), Expect = 2e-27
 Identities = 82/252 (32%), Positives = 130/252 (51%), Gaps = 30/252 (11%)

Query: 21  AIKIIDKTQLD-EENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           A+KIIDK++ D  E ++ + R  Q      HP+II L  V +  + +YLV E   GGE+ 
Sbjct: 442 AVKIIDKSKRDPSEEIEILLRYGQ------HPNIITLKDVYDDGKFVYLVMELMRGGELL 495

Query: 80  DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADF 135
           D ++     +E+EA      I   + + H + +VHRDLK  N+L      +  +I++ DF
Sbjct: 496 DRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDF 555

Query: 136 GFSNLFTPGQ-LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF--- 191
           GF+     G  LL T C +  + APE+ + + YD    DIWSLG++LY ++ G  PF   
Sbjct: 556 GFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDA-ACDIWSLGILLYTMLAGFTPFANG 614

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
              T + + AR+ SGK+     +S G    +    K           ++  ML +DP++R
Sbjct: 615 PDDTPEEILARIGSGKYA----LSGGNWDSISDAAK----------DVVSKMLHVDPHQR 660

Query: 252 LSMEQICKHKWM 263
           L+  Q+ KH W+
Sbjct: 661 LTAMQVLKHPWV 672



 Score =  114 bits (285), Expect = 2e-25
 Identities = 71/249 (28%), Positives = 122/249 (48%), Gaps = 25/249 (10%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           QL A+K++ K  L   +  +   E  I+  + HP I++L+   +TE  +YL+ ++  GG+
Sbjct: 86  QLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD 145

Query: 78  IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           +F  L       E++ +    ++  A+   H   I++RDLK EN+LLD   +IKI DFG 
Sbjct: 146 LFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL 205

Query: 138 S-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196
           S       +   ++CG+  Y APE+   + +     D WS GV+++ ++ G+LPF G   
Sbjct: 206 SKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGSLPFQGKDR 264

Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL---- 252
           +   A +L  K  +P F+S                   E + L+R +   +P  RL    
Sbjct: 265 KETMALILKAKLGMPQFLS------------------GEAQSLLRALFKRNPCNRLGAGI 306

Query: 253 -SMEQICKH 260
             +E+I +H
Sbjct: 307 DGVEEIKRH 315



>gi|1346393|sp|P24723|KPCL_HUMAN   Protein kinase C, eta type (nPKC-eta) (PKC-L)
          Length = 682

 Score =  120 bits (302), Expect = 3e-27
 Identities = 73/246 (29%), Positives = 135/246 (54%), Gaps = 10/246 (4%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63
           G ++   ++ET  L A+K++ K   L +++++    E +I+ +   HP + +L+   +T 
Sbjct: 366 GKVMLARVKETGDLYAVKVLKKDVILLDDDVECTMTEKRILSLARNHPFLTQLFCCFQTP 425

Query: 64  RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123
             ++ V E+ +GG++  H+    R  E  AR    +I++A+ F H + I++RDLK +N+L
Sbjct: 426 DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVL 485

Query: 124 LDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182
           LD   + K+ADFG        G    T+CG+P Y APE+ +   Y GP VD W++GV+LY
Sbjct: 486 LDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY-GPAVDWWAMGVLLY 544

Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFM---STGLVPEL---DKRLKAGCLSIAEC 236
            ++CG  PF+     +L   +L+ +   P ++   +TG++      +  ++ G L+    
Sbjct: 545 EMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGE 604

Query: 237 EHLIRH 242
             ++RH
Sbjct: 605 HAILRH 610



>gi|41017502|sp|Q96RG2|PASK_HUMAN   PAS domain containing serine/threonine-protein kinase (PAS-kinase)
            (PASKIN) (hPASK)
          Length = 1323

 Score =  120 bits (301), Expect = 3e-27
 Identities = 60/170 (35%), Positives = 102/170 (60%), Gaps = 1/170 (0%)

Query: 23   KIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE-YASGGEIFDH 81
            K+++   +++  L K+  E+ I+  + H +II++  + E +    LV E + SG ++F  
Sbjct: 1034 KVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAF 1093

Query: 82   LVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF 141
            +  H R+ E  A   F+Q+V+AV +   ++I+HRD+K EN+++  +  IK+ DFG +   
Sbjct: 1094 IDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYL 1153

Query: 142  TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
              G+L  T+CG+  Y APE+  G  Y GP++++WSLGV LY LV    PF
Sbjct: 1154 ERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF 1203



>gi|34098463|sp|Q86SG6|NEK8_HUMAN   Serine/threonine-protein kinase Nek8 (NimA-related protein kinase
           8) (NIMA-related kinase 12a)
          Length = 692

 Score =  119 bits (297), Expect = 1e-26
 Identities = 69/195 (35%), Positives = 110/195 (56%), Gaps = 4/195 (2%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           ++LV IK I   Q+ +E  +    E Q++K+L HP++I  Y+    ++ + +  EYA GG
Sbjct: 27  QKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGG 86

Query: 77  EIFDHLV--AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDAN-LNIKIA 133
            + + +    +  + E+     F QI+ A++  H   I+HRDLK +N+LLD + + +KI 
Sbjct: 87  TLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIG 146

Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           DFG S + +      T  G+P Y +PEL EGK Y+  K DIW+LG VLY L      F+ 
Sbjct: 147 DFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-QKSDIWALGCVLYELASLKRAFEA 205

Query: 194 STLQNLRARVLSGKF 208
           + L  L  +++SG F
Sbjct: 206 ANLPALVLKIMSGTF 220



>gi|1709658|sp|P53350|PLK1_HUMAN   Serine/threonine-protein kinase PLK1 (Polo-like kinase 1) (PLK-1)
           (Serine-threonine protein kinase 13) (STPK13)
          Length = 603

 Score =  117 bits (294), Expect = 2e-26
 Identities = 74/254 (29%), Positives = 126/254 (49%), Gaps = 21/254 (8%)

Query: 15  ETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           +TK++ A KI+ K+ L + + + K+  E+ I + L H H++  +   E    +++V E  
Sbjct: 74  DTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELC 133

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
               + +       + E EAR   +QIV    + H   ++HRDLK  NL L+ +L +KI 
Sbjct: 134 RRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIG 193

Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           DFG  + +   G+  KT CG+P Y APE+   K +   +VD+WS+G ++Y L+ G  PF+
Sbjct: 194 DFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSF-EVDVWSIGCIMYTLLVGKPPFE 252

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
            S L+    R+   ++ IP            K +     S      LI+ ML  DP  R 
Sbjct: 253 TSCLKETYLRIKKNEYSIP------------KHINPVAAS------LIQKMLQTDPTARP 294

Query: 253 SMEQICKHKWMKLG 266
           ++ ++   ++   G
Sbjct: 295 TINELLNDEFFTSG 308



>gi|56404656|sp|Q96RR4|KKCC2_HUMAN   Calcium/calmodulin-dependent protein kinase kinase 2
           (Calcium/calmodulin-dependent protein kinase kinase
           beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK
           beta)
          Length = 588

 Score =  117 bits (294), Expect = 2e-26
 Identities = 72/241 (29%), Positives = 127/241 (52%), Gaps = 22/241 (9%)

Query: 35  LKKIFREVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKE 92
           ++++++E+ I+K L HP++++L +V++   E  +Y+V E  + G + + +     ++E +
Sbjct: 230 IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQ 288

Query: 93  ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ-LLKTWC 151
           AR  F+ ++  + + H + I+HRD+K  NLL+  + +IKIADFG SN F     LL    
Sbjct: 289 ARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTV 348

Query: 152 GSPPYAAPELFE--GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR 209
           G+P + APE      K + G  +D+W++GV LY  V G  PF    +  L +++ S    
Sbjct: 349 GTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALE 408

Query: 210 IPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDAD 269
            P        P++ + LK           LI  ML  +P  R+ + +I  H W+    A+
Sbjct: 409 FPD------QPDIAEDLK----------DLITRMLDKNPESRIVVPEIKLHPWVTRHGAE 452

Query: 270 P 270
           P
Sbjct: 453 P 453



>gi|125549|sp|P17252|KPCA_HUMAN   Protein kinase C, alpha type (PKC-alpha) (PKC-A)
          Length = 672

 Score =  117 bits (293), Expect = 3e-26
 Identities = 67/203 (33%), Positives = 113/203 (55%), Gaps = 4/203 (1%)

Query: 16  TKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHII-RLYQVMETERMIYLVTEYA 73
           T++L AIKI+ K   + +++++    E +++ +L  P  + +L+   +T   +Y V EY 
Sbjct: 361 TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV 420

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
           +GG++  H+   G+  E +A     +I   ++F H R I++RDLK +N++LD+  +IKIA
Sbjct: 421 NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA 480

Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           DFG        G   +T+CG+P Y APE+   + Y G  VD W+ GV+LY ++ G  PFD
Sbjct: 481 DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY-GKSVDWWAYGVLLYEMLAGQPPFD 539

Query: 193 GSTLQNLRARVLSGKFRIPFFMS 215
           G     L   ++      P  +S
Sbjct: 540 GEDEDELFQSIMEHNVSYPKSLS 562



>gi|400135|sp|Q02156|KPCE_HUMAN   Protein kinase C, epsilon type (nPKC-epsilon)
          Length = 737

 Score =  116 bits (290), Expect = 6e-26
 Identities = 70/245 (28%), Positives = 128/245 (52%), Gaps = 10/245 (4%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63
           G ++   L+   ++ A+K++ K   L ++++     E +I+ +   HP++ +LY   +T+
Sbjct: 420 GKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTK 479

Query: 64  RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123
             ++ V EY +GG++   +    +  E  +R    ++ +A+ F H   +++RDLK +N+L
Sbjct: 480 DRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNIL 539

Query: 124 LDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182
           LDA  + K+ADFG        G    T+CG+P Y APE+ +  EY GP VD W+LGV++Y
Sbjct: 540 LDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEY-GPSVDWWALGVLMY 598

Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPEL------DKRLKAGCLSIAEC 236
            ++ G  PF+     +L   +L      P ++S   V  L      +   + GC++    
Sbjct: 599 EMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNG 658

Query: 237 EHLIR 241
           E  I+
Sbjct: 659 EDAIK 663



>gi|3024670|sp|Q15831|STK11_HUMAN   Serine/threonine-protein kinase 11 (Serine/threonine-protein kinase
           LKB1)
          Length = 433

 Score =  116 bits (290), Expect = 6e-26
 Identities = 82/257 (31%), Positives = 126/257 (49%), Gaps = 35/257 (13%)

Query: 21  AIKIIDKTQL-----DEENLKKIFREVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYA 73
           A+KI+ K +L      E N+KK   E+Q+++ L H ++I+L  V+  E ++ +Y+V EY 
Sbjct: 76  AVKILKKKKLRRIPNGEANVKK---EIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYC 132

Query: 74  SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
             G  E+ D  V   R    +A   F Q++  + + H + IVH+D+K  NLLL     +K
Sbjct: 133 VCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLK 191

Query: 132 IADFGFSNLFTP---GQLLKTWCGSPPYAAPELFEGKE-YDGPKVDIWSLGVVLYVLVCG 187
           I+D G +    P       +T  GSP +  PE+  G + + G KVDIWS GV LY +  G
Sbjct: 192 ISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTG 251

Query: 188 ALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLD 247
             PF+G  +  L   +  G + IP      L                    L++ ML  +
Sbjct: 252 LYPFEGDNIYKLFENIGKGSYAIPGDCGPPL------------------SDLLKGMLEYE 293

Query: 248 PNKRLSMEQICKHKWMK 264
           P KR S+ QI +H W +
Sbjct: 294 PAKRFSIRQIRQHSWFR 310



>gi|462455|sp|P05129|KPCG_HUMAN   Protein kinase C, gamma type (PKC-gamma)
          Length = 697

 Score =  115 bits (288), Expect = 1e-25
 Identities = 62/168 (36%), Positives = 95/168 (56%), Gaps = 5/168 (2%)

Query: 51  PHII-RLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC 109
           PH + +L+   +T   +Y V EY +GG++  H+   G+  E  A     +I   ++F H 
Sbjct: 414 PHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHN 473

Query: 110 RNIVHRDLKAENLLLDANLNIKIADFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEY 167
           + I++RDLK +N++LDA  +IKI DFG    N+F PG   +T+CG+P Y APE+   + Y
Sbjct: 474 QGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVF-PGTTTRTFCGTPDYIAPEIIAYQPY 532

Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMS 215
            G  VD WS GV+LY ++ G  PFDG   + L   ++      P  +S
Sbjct: 533 -GKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLS 579



>gi|56404620|sp|Q8N5S9|KKCC1_HUMAN   Calcium/calmodulin-dependent protein kinase kinase 1
           (Calcium/calmodulin-dependent protein kinase kinase
           alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK
           alpha) (CaMKK 1) (CaM-kinase IV kinase)
          Length = 505

 Score =  115 bits (287), Expect = 1e-25
 Identities = 71/241 (29%), Positives = 122/241 (50%), Gaps = 22/241 (9%)

Query: 35  LKKIFREVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKE 92
           L+++++E+ I+K L H ++++L +V++   E  +YLV +    G + + +      +E++
Sbjct: 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQ 251

Query: 93  ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL-LKTWC 151
           AR   + ++  + + HC+ IVHRD+K  NLLL  + ++KIADFG SN F      L +  
Sbjct: 252 ARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTA 311

Query: 152 GSPPYAAPELF--EGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR 209
           G+P + APE     G+ + G  +D+W+ GV LY  V G  PF    +  L  ++ +    
Sbjct: 312 GTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVV 371

Query: 210 IPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDAD 269
            P        PE+ + LK           LI  ML  +P  R+ +  I  H W+     +
Sbjct: 372 FP------EEPEISEELK----------DLILKMLDKNPETRIGVPDIKLHPWVTKNGEE 415

Query: 270 P 270
           P
Sbjct: 416 P 416



>gi|2499575|sp|Q15139|KPCM_HUMAN   Protein kinase C, mu type (nPKC-mu) (Protein kinase D)
          Length = 912

 Score =  115 bits (287), Expect = 1e-25
 Identities = 76/256 (29%), Positives = 134/256 (52%), Gaps = 23/256 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           ++T + VAIKIIDK +   +   ++  EV I++ L HP ++ L  + ET   +++V E  
Sbjct: 603 RKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKL 662

Query: 74  SGGEIFDHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128
             G++ + +++   GR+ E   +    QI+ A+   H +NIVH DLK EN+LL   D   
Sbjct: 663 H-GDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP 721

Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188
            +K+ DFGF+ +       ++  G+P Y APE+   K Y+   +D+WS+GV++YV + G 
Sbjct: 722 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYN-RSLDMWSVGVIIYVSLSGT 780

Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248
            PF+    +++  ++ +  F  P        P   K +        E   LI ++L +  
Sbjct: 781 FPFNED--EDIHDQIQNAAFMYP--------PNPWKEIS------HEAIDLINNLLQVKM 824

Query: 249 NKRLSMEQICKHKWMK 264
            KR S+++   H W++
Sbjct: 825 RKRYSVDKTLSHPWLQ 840



>gi|28558166|sp|Q9HBY8|SGK2_HUMAN   Serine/threonine-protein kinase Sgk2 (Serum/glucocorticoid
           regulated kinase 2)
          Length = 427

 Score =  114 bits (286), Expect = 2e-25
 Identities = 73/235 (31%), Positives = 116/235 (49%), Gaps = 22/235 (9%)

Query: 21  AIKIIDKTQ-LDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78
           A+K++ K   L ++    I  E  ++ K + HP ++ L    +T   +Y V +Y +GGE+
Sbjct: 122 AVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGEL 181

Query: 79  FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF- 137
           F HL    R  E  AR    ++ +A+ + H  NI++RDLK EN+LLD   ++ + DFG  
Sbjct: 182 FFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLC 241

Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ 197
                P     T+CG+P Y APE+   + YD   VD W LG VLY ++ G  PF    + 
Sbjct: 242 KEGVEPEDTTSTFCGTPEYLAPEVLRKEPYD-RAVDWWCLGAVLYEMLHGLPPFYSQDVS 300

Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
            +   +L    +IP                 G  ++A C+ L++ +L  D  +RL
Sbjct: 301 QMYENILHQPLQIP-----------------GGRTVAACD-LLQSLLHKDQRQRL 337



>gi|125379|sp|P14619|KGP1B_HUMAN   cGMP-dependent protein kinase 1, beta isozyme (cGK 1 beta)
           (cGKI-beta)
          Length = 686

 Score =  114 bits (285), Expect = 2e-25
 Identities = 78/256 (30%), Positives = 124/256 (48%), Gaps = 23/256 (8%)

Query: 15  ETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           E  +  A+KI+ K  + D    + I  E QIM+      I+RLY+  +  + +Y++ E  
Sbjct: 397 EESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEAC 456

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
            GGE++  L   G   +   R     +V A  + H + I++RDLK ENL+LD     K+ 
Sbjct: 457 LGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLV 516

Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           DFGF+     G+   T+CG+P Y APE+   K +D    D WSLG+++Y L+ G+ PF G
Sbjct: 517 DFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD-ISADYWSLGILMYELLTGSPPFSG 575

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252
                    +L G   I          E  K++           +LI+ +   +P++RL 
Sbjct: 576 PDPMKTYNIILRGIDMI----------EFPKKI------AKNAANLIKKLCRDNPSERLG 619

Query: 253 ----SMEQICKHKWMK 264
                ++ I KHKW +
Sbjct: 620 NLKNGVKDIQKHKWFE 635



>gi|6225588|sp|Q13976|KGP1A_HUMAN   cGMP-dependent protein kinase 1, alpha isozyme (CGK 1 alpha)
           (cGKI-alpha)
          Length = 671

 Score =  114 bits (285), Expect = 2e-25
 Identities = 78/256 (30%), Positives = 124/256 (48%), Gaps = 23/256 (8%)

Query: 15  ETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           E  +  A+KI+ K  + D    + I  E QIM+      I+RLY+  +  + +Y++ E  
Sbjct: 382 EESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEAC 441

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
            GGE++  L   G   +   R     +V A  + H + I++RDLK ENL+LD     K+ 
Sbjct: 442 LGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLV 501

Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           DFGF+     G+   T+CG+P Y APE+   K +D    D WSLG+++Y L+ G+ PF G
Sbjct: 502 DFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD-ISADYWSLGILMYELLTGSPPFSG 560

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL- 252
                    +L G   I          E  K++           +LI+ +   +P++RL 
Sbjct: 561 PDPMKTYNIILRGIDMI----------EFPKKI------AKNAANLIKKLCRDNPSERLG 604

Query: 253 ----SMEQICKHKWMK 264
                ++ I KHKW +
Sbjct: 605 NLKNGVKDIQKHKWFE 620



>gi|20138711|sp|Q9BZL6|KPCD2_HUMAN   Protein kinase C, D2 type (nPKC-D2) (Protein kinase D2) (HSPC187)
          Length = 878

 Score =  113 bits (282), Expect = 5e-25
 Identities = 73/256 (28%), Positives = 135/256 (52%), Gaps = 23/256 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           ++T + VA+K+IDK +   +   ++  EV I++ L HP I+ L  + ET   +++V E  
Sbjct: 571 RKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKL 630

Query: 74  SGGEIFDHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128
             G++ + +++   GR+ E+  +    QI+ A+   H +NIVH DLK EN+LL   D   
Sbjct: 631 H-GDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP 689

Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188
            +K+ DFGF+ +       ++  G+P Y APE+   + Y+   +D+WS+GV++YV + G 
Sbjct: 690 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYN-RSLDMWSVGVIMYVSLSGT 748

Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248
            PF+    +++  ++ +  F  P              + AG +       LI ++L +  
Sbjct: 749 FPFNED--EDINDQIQNAAFMYP--------ASPWSHISAGAID------LINNLLQVKM 792

Query: 249 NKRLSMEQICKHKWMK 264
            KR S+++   H W++
Sbjct: 793 RKRYSVDKSLSHPWLQ 808



>gi|20141488|sp|P05771|KPCB_HUMAN   Protein kinase C, beta type (PKC-beta) (PKC-B)
          Length = 671

 Score =  113 bits (282), Expect = 5e-25
 Identities = 66/204 (32%), Positives = 112/204 (54%), Gaps = 6/204 (2%)

Query: 16  TKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHII-RLYQVMETERMIYLVTEYA 73
           T +L A+KI+ K   + +++++    E +++ +   P  + +L+   +T   +Y V EY 
Sbjct: 364 TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYV 423

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
           +GG++  H+   GR  E  A     +I   ++F   + I++RDLK +N++LD+  +IKIA
Sbjct: 424 NGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIA 483

Query: 134 DFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           DFG    N++  G   KT+CG+P Y APE+   + Y G  VD W+ GV+LY ++ G  PF
Sbjct: 484 DFGMCKENIW-DGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPF 541

Query: 192 DGSTLQNLRARVLSGKFRIPFFMS 215
           +G     L   ++      P  MS
Sbjct: 542 EGEDEDELFQSIMEHNVAYPKSMS 565



>gi|17380162|sp|O15530|PDPK1_HUMAN   3-phosphoinositide dependent protein kinase-1 (hPDK1)
          Length = 556

 Score =  112 bits (280), Expect = 9e-25
 Identities = 72/248 (29%), Positives = 122/248 (49%), Gaps = 27/248 (10%)

Query: 16  TKQLVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T +  AIKI++K  + +EN +  + RE  +M  L HP  ++LY   + +  +Y    YA 
Sbjct: 104 TSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAK 163

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
            GE+  ++   G   E   R    +IV+A+ + H + I+HRDLK EN+LL+ +++I+I D
Sbjct: 164 NGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITD 223

Query: 135 FGFSNLFTPGQ---LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           FG + + +P        ++ G+  Y +PEL   K       D+W+LG ++Y LV G  PF
Sbjct: 224 FGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS-ACKSSDLWALGCIIYQLVAGLPPF 282

Query: 192 DGSTLQNLRARVLSGKFRIP--FFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPN 249
                  +  +++  ++  P  FF                     +   L+  +LVLD  
Sbjct: 283 RAGNEYLIFQKIIKLEYDFPEKFF--------------------PKARDLVEKLLVLDAT 322

Query: 250 KRLSMEQI 257
           KRL  E++
Sbjct: 323 KRLGCEEM 330



>gi|52000829|sp|Q8IW41|MAPK5_HUMAN   MAP kinase-activated protein kinase 5 (MAPK-activated protein
           kinase 5) (MAPKAP kinase 5) (p38-regulated/activated
           protein kinase)
          Length = 473

 Score =  112 bits (279), Expect = 1e-24
 Identities = 92/343 (26%), Positives = 161/343 (46%), Gaps = 67/343 (19%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLC--HPHIIRLYQVMETE-------- 63
           + T++  A+KI+    LD    +   R    + M+C  HP+I+++ +V            
Sbjct: 42  KSTQERFALKIL----LDRPKARNEVR----LHMMCATHPNIVQIIEVFANSVQFPHESS 93

Query: 64  --RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121
               + +V E   GGE+F  +  H    EK+A +  KQI  A+  CH  NI HRDLK EN
Sbjct: 94  PRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPEN 153

Query: 122 LLLDAN---LNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEG-----KEYDG---- 169
           LL   N     +K+ DFGF+ +   G L+ T   +P Y AP++ E      KE  G    
Sbjct: 154 LLFKDNSLDAPVKLCDFGFAKI-DQGDLM-TPQFTPYYVAPQVLEAQRRHQKEKSGIIPT 211

Query: 170 --------PKVDIWSLGVVLYVLVCGALPF-----DGSTLQNLRARVLSGKFRIPFFMST 216
                      D+WSLGV++YV++CG  PF       +  +++R ++++G F  P     
Sbjct: 212 SPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFP----- 266

Query: 217 GLVPELDKRLKAGCLSIAE-CEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRL 275
                     +     I+E  + ++R +L + P +RL++E +  H W+   +A    D +
Sbjct: 267 ----------EEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEA---LDNV 313

Query: 276 IAECQQLKEERQVDPLNEDVLLAMEDMGL-DKEQTLQPDGTLN 317
           +   Q + ++  V  + +     + +M + D + +L+P  ++N
Sbjct: 314 LPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVN 356



>gi|24211884|sp|Q9H1R3|MYLK2_HUMAN   Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2)
          Length = 596

 Score =  111 bits (278), Expect = 2e-24
 Identities = 76/250 (30%), Positives = 120/250 (48%), Gaps = 26/250 (10%)

Query: 20  VAIKIIDK-TQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78
           +A K+I K T  D+E    +  E+++M  L H ++I+LY  +ET   I L  EY  GGE+
Sbjct: 311 LAAKVIKKQTPKDKE---MVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGEL 367

Query: 79  FDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN--IKIADF 135
           F+ +V     + E +     +QI   + F H   ++H DLK EN+L        +KI DF
Sbjct: 368 FERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDF 427

Query: 136 GFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFDG 193
           G +  + P + LK   G+P + +PE+     YD    K D+WS+GV+ Y+L+ G  PF G
Sbjct: 428 GLARRYNPNEKLKVNFGTPEFLSPEVV---NYDQISDKTDMWSMGVITYMLLSGLSPFLG 484

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253
                    VLSG +   +F         D           E +  + +++V D   R++
Sbjct: 485 DDDTETLNNVLSGNW---YFDEETFEAVSD-----------EAKDFVSNLIVKDQRARMN 530

Query: 254 MEQICKHKWM 263
             Q   H W+
Sbjct: 531 AAQCLAHPWL 540



>gi|12230239|sp|O94806|KPCN_HUMAN   Protein kinase C, nu type (nPKC-nu) (Protein kinase EPK2)
          Length = 890

 Score =  110 bits (276), Expect = 3e-24
 Identities = 73/256 (28%), Positives = 134/256 (52%), Gaps = 23/256 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           ++T + VAIK+IDK +   +   ++  EV I++ L HP I+ L  + ET   +++V E  
Sbjct: 596 RKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKL 655

Query: 74  SGGEIFDHLVA--HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---DANL 128
             G++ + +++    R+ E+  +    QI+ A+   H +NIVH DLK EN+LL   +   
Sbjct: 656 H-GDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFP 714

Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188
            +K+ DFGF+ +       ++  G+P Y APE+   K Y+   +D+WS+GV++YV + G 
Sbjct: 715 QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYN-RSLDMWSVGVIIYVSLSGT 773

Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248
            PF+    +++  ++ +  F  P        P   + +        E   LI ++L +  
Sbjct: 774 FPFNED--EDINDQIQNAAFMYP--------PNPWREIS------GEAIDLINNLLQVKM 817

Query: 249 NKRLSMEQICKHKWMK 264
            KR S+++   H W++
Sbjct: 818 RKRYSVDKSLSHPWLQ 833



>gi|3041712|sp|Q13177|PAK2_HUMAN   Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
           (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase)
          Length = 524

 Score =  110 bits (275), Expect = 3e-24
 Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 20/249 (8%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           Q VAIK I+  +  ++ L  I  E+ +MK L +P+I+           +++V EY +GG 
Sbjct: 273 QEVAIKQINLQKQPKKEL--IINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGS 330

Query: 78  IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           + D +V    M E +     ++ + A+ F H   ++HRD+K++N+LL    ++K+ DFGF
Sbjct: 331 LTD-VVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGF 389

Query: 138 SNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196
               TP Q  + T  G+P + APE+   K Y GPKVDIWSLG++   +V G  P+     
Sbjct: 390 CAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY----- 443

Query: 197 QNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQ 256
                 +     R  + ++T   PEL    K   +        +   L +D  KR S ++
Sbjct: 444 ------LNENPLRALYLIATNGTPELQNPEKLSPI----FRDFLNRCLEMDVEKRGSAKE 493

Query: 257 ICKHKWMKL 265
           + +H ++KL
Sbjct: 494 LLQHPFLKL 502



>gi|1709252|sp|P51955|NEK2_HUMAN   Serine/threonine-protein kinase Nek2 (NimA-related protein kinase
           2) (NimA-like protein kinase 1) (HSPK 21)
          Length = 445

 Score =  109 bits (273), Expect = 6e-24
 Identities = 86/309 (27%), Positives = 146/309 (47%), Gaps = 22/309 (7%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQ--VMETERMIYLVTEYASG 75
           +++  K +D   + E   + +  EV +++ L HP+I+R Y   +  T   +Y+V EY  G
Sbjct: 32  KILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEG 91

Query: 76  GEIFDHLVAHGR----MAEKEARRKFKQIVTAVYFCHCRN-----IVHRDLKAENLLLDA 126
           G++   +    +    + E+   R   Q+  A+  CH R+     ++HRDLK  N+ LD 
Sbjct: 92  GDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDG 151

Query: 127 NLNIKIADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185
             N+K+ DFG + +        KT+ G+P Y +PE      Y+  K DIWSLG +LY L 
Sbjct: 152 KQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYN-EKSDIWSLGCLLYELC 210

Query: 186 CGALPFDGSTLQNLRARVLSGKF-RIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244
               PF   + + L  ++  GKF RIP+  S  L   + + L          E ++ + L
Sbjct: 211 ALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL 270

Query: 245 VLD---PNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMED 301
           + D     +R ++E+    +  +LG+ + + D      +   +E Q+    E  L A E+
Sbjct: 271 IADLVADEQRRNLER----RGRQLGEPEKSQDSSPVLSELKLKEIQLQE-RERALKAREE 325

Query: 302 MGLDKEQTL 310
               KEQ L
Sbjct: 326 RLEQKEQEL 334



>gi|2499643|sp|Q13153|PAK1_HUMAN   Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
           (PAK-1) (P65-PAK) (Alpha-PAK)
          Length = 545

 Score =  109 bits (273), Expect = 6e-24
 Identities = 76/267 (28%), Positives = 134/267 (50%), Gaps = 20/267 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T Q VAIK ++  Q  ++ L  I  E+ +M+   +P+I+           +++V EY +G
Sbjct: 292 TGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 349

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           G + D +V    M E +     ++ + A+ F H   ++HRD+K++N+LL  + ++K+ DF
Sbjct: 350 GSLTD-VVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 408

Query: 136 GFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194
           GF    TP Q  + T  G+P + APE+   K Y GPKVDIWSLG++   ++ G  P+   
Sbjct: 409 GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMIEGEPPY--- 464

Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSM 254
                   +     R  + ++T   PEL    K   +        +   L +D  KR S 
Sbjct: 465 --------LNENPLRALYLIATNGTPELQNPEKLSAI----FRDFLNRCLDMDVEKRGSA 512

Query: 255 EQICKHKWMKLGDADPNFDRLIAECQQ 281
           +++ +H+++K+     +   LIA  ++
Sbjct: 513 KELLQHQFLKIAKPLSSLTPLIAAAKE 539



>gi|12644418|sp|Q15746|MYLK_HUMAN   Myosin light chain kinase, smooth muscle and non-muscle isozymes
            (MLCK) [Contains: Telokin (Kinase related protein) (KRP)]
          Length = 1914

 Score =  109 bits (273), Expect = 6e-24
 Identities = 82/295 (27%), Positives = 134/295 (45%), Gaps = 27/295 (9%)

Query: 31   DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHG-RMA 89
            ++EN+++   E+ IM  L HP +++     E +  I +V E  SGGE+F+ ++     + 
Sbjct: 1502 EKENIRQ---EISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELT 1558

Query: 90   EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL--DANLNIKIADFGFSNLFTPGQLL 147
            E+E  +  +QI   V + H + IVH DLK EN++        IK+ DFG +        L
Sbjct: 1559 ERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSL 1618

Query: 148  KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF----DGSTLQNLRARV 203
            K   G+P + APE+    E  G   D+WS+GV+ Y+LV G  PF    D  TL N+ +  
Sbjct: 1619 KVLFGTPEFVAPEVI-NYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSAT 1677

Query: 204  LSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICK---- 259
                      +S      +   LK    +  +C   ++H  ++   K +  +++ K    
Sbjct: 1678 WDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMK 1737

Query: 260  -----HKWMKLGDADPNFDRL--IAECQQLKEERQ-----VDPLNEDVLLAMEDM 302
                  KW K G+A     RL  +A    L   +        PLN + L + ED+
Sbjct: 1738 KYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDV 1792



>gi|20141582|sp|Q04759|KPCT_HUMAN   Protein kinase C, theta type (nPKC-theta)
          Length = 706

 Score =  109 bits (272), Expect = 8e-24
 Identities = 93/318 (29%), Positives = 152/318 (47%), Gaps = 41/318 (12%)

Query: 5   KGYIIQDFLQE---TKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQV 59
           KG   + FL E   T Q  AIK + K   L +++++    E +++ +   HP +  ++  
Sbjct: 388 KGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCT 447

Query: 60  METERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKA 119
            +T+  ++ V EY +GG++  H+ +  +     A     +I+  + F H + IV+RDLK 
Sbjct: 448 FQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKL 507

Query: 120 ENLLLDANLNIKIADFGFSNLFTPGQL-LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLG 178
           +N+LLD + +IKIADFG       G     T+CG+P Y APE+  G++Y+   VD WS G
Sbjct: 508 DNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYN-HSVDWWSFG 566

Query: 179 VVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH 238
           V+LY ++ G  PF G   + L   +   +   PF+        L+K          E + 
Sbjct: 567 VLLYEMLIGQSPFHGQDEEELFHSI---RMDNPFYPRW-----LEK----------EAKD 608

Query: 239 LIRHMLVLDPNKRLSME-QICKH------KWMKL--GDADPNFDRLIA---ECQQLKEER 286
           L+  + V +P KRL +   I +H       W +L   + DP F   +    +C    +E 
Sbjct: 609 LLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEF 668

Query: 287 QVDPLNEDVLLAMEDMGL 304
               LNE   L+  D  L
Sbjct: 669 ----LNEKPRLSFADRAL 682



>gi|60390226|sp|Q9Y2H9|MAST1_HUMAN   Microtubule-associated serine/threonine-protein kinase 1
           (Syntrophin-associated serine/threonine-protein kinase)
          Length = 1570

 Score =  109 bits (272), Expect = 8e-24
 Identities = 83/256 (32%), Positives = 127/256 (49%), Gaps = 33/256 (12%)

Query: 14  QETKQLVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           ++T+Q  A+K I+K  L   N +++ F E  I+    +P ++ ++   ET R + +V EY
Sbjct: 394 RDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEY 453

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
             GG+    L   G +  + AR  F + V A+ + H   IVHRDLK +NLL+ +  +IK+
Sbjct: 454 VEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKL 513

Query: 133 ADFGFS---------NLF-------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176
            DFG S         NL+           L K  CG+P Y APE+   + Y G  VD W+
Sbjct: 514 TDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY-GKPVDWWA 572

Query: 177 LGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAEC 236
           +G++LY  + G +PF G T + L  +V+S            L PE D+ L        E 
Sbjct: 573 MGIILYEFLVGCVPFFGDTPEELFGQVISDDI---------LWPEGDEALP------TEA 617

Query: 237 EHLIRHMLVLDPNKRL 252
           + LI  +L  +P  RL
Sbjct: 618 QLLISSLLQTNPLVRL 633



>gi|22256934|sp|Q96PY6|NEK1_HUMAN   Serine/threonine-protein kinase Nek1 (NimA-related protein kinase
           1) (NY-REN-55 antigen)
          Length = 1258

 Score =  108 bits (271), Expect = 1e-23
 Identities = 61/190 (32%), Positives = 109/190 (57%), Gaps = 4/190 (2%)

Query: 22  IKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDH 81
           IK I+ +++  +  ++  REV ++  + HP+I++  +  E    +Y+V +Y  GG++F  
Sbjct: 32  IKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKR 91

Query: 82  LVAHGRMA--EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN 139
           + A   +   E +    F QI  A+   H R I+HRD+K++N+ L  +  +++ DFG + 
Sbjct: 92  INAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIAR 151

Query: 140 -LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN 198
            L +  +L +T  G+P Y +PE+ E K Y+  K DIW+LG VLY L      F+  +++N
Sbjct: 152 VLNSTVELARTCIGTPYYLSPEICENKPYNN-KSDIWALGCVLYELCTLKHAFEAGSMKN 210

Query: 199 LRARVLSGKF 208
           L  +++SG F
Sbjct: 211 LVLKIISGSF 220



>gi|3914977|sp|O00141|SGK1_HUMAN   Serine/threonine-protein kinase Sgk1
           (Serum/glucocorticoid-regulated kinase 1)
          Length = 431

 Score =  108 bits (271), Expect = 1e-23
 Identities = 89/299 (29%), Positives = 135/299 (45%), Gaps = 37/299 (12%)

Query: 21  AIKIIDKTQ-LDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78
           A+K++ K   L ++  K I  E  ++ K + HP ++ L+   +T   +Y V +Y +GGE+
Sbjct: 125 AVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGEL 184

Query: 79  FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF- 137
           F HL       E  AR    +I +A+ + H  NIV+RDLK EN+LLD+  +I + DFG  
Sbjct: 185 FYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLC 244

Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQ 197
                      T+CG+P Y APE+   + YD   VD W LG VLY ++ G  PF      
Sbjct: 245 KENIEHNSTTSTFCGTPEYLAPEVLHKQPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNTA 303

Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME-- 255
            +   +L+   +        L P +               HL+  +L  D  KRL  +  
Sbjct: 304 EMYDNILNKPLQ--------LKPNITN----------SARHLLEGLLQKDRTKRLGAKDD 345

Query: 256 --QICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQP 312
             +I  H +  L     N+D LI        ++   P N +V    E    D E T +P
Sbjct: 346 FMEIKSHVFFSL----INWDDLI-------NKKITPPFNPNVSGPNELRHFDPEFTEEP 393



>gi|56405369|sp|Q00532|KKIA_HUMAN   Serine/threonine-protein kinase KKIALRE (Cyclin-dependent
           kinase-like 1)
          Length = 358

 Score =  108 bits (271), Expect = 1e-23
 Identities = 84/272 (30%), Positives = 136/272 (50%), Gaps = 28/272 (10%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           ++T Q+VAIK   +++ D+  +KKI  RE++++K L HP+++ L +V   +R ++LV EY
Sbjct: 25  RDTGQIVAIKKFLESE-DDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEY 83

Query: 73  ASGGEIFDHLVAHGR------MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA 126
                  DH V H        + E   +    Q + AV FCH  N +HRD+K EN+L+  
Sbjct: 84  C------DHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITK 137

Query: 127 NLNIKIADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185
           +  IK+ DFGF+ L T P      +  +  Y +PEL  G    GP VD+W++G V   L+
Sbjct: 138 HSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELL 197

Query: 186 CGALPFDG-----------STLQNLRARVLSGKFRIPFFMSTGLV-PELDKRLKAGCLSI 233
            G   + G            TL +L  R         +F    +  PE  + L+    +I
Sbjct: 198 SGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNI 257

Query: 234 A-ECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
           +     L++  L +DP +RL+ EQ+  H + +
Sbjct: 258 SYPALGLLKGCLHMDPTERLTCEQLLHHPYFE 289



>gi|6225859|sp|Q16513|PKL2_HUMAN   Protein kinase N2 (Protein kinase C-like 2) (Protein-kinase
           C-related kinase 2)
          Length = 984

 Score =  108 bits (270), Expect = 1e-23
 Identities = 81/284 (28%), Positives = 134/284 (47%), Gaps = 36/284 (12%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQL---DEENL----KKIFREVQIMKMLCHPHIIRLYQ 58
           G ++    + T ++ AIK + K  +   DE +     K+IF  V  ++   HP ++ L+ 
Sbjct: 669 GKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR---HPFLVNLFA 725

Query: 59  VMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLK 118
             +T+  +  V EYA+GG++  H+      +E  A      +V  + + H   IV+RDLK
Sbjct: 726 CFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEPRAVFYAACVVLGLQYLHEHKIVYRDLK 784

Query: 119 AENLLLDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSL 177
            +NLLLD    +KIADFG        G    T+CG+P + APE+     Y    VD W L
Sbjct: 785 LDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYT-RAVDWWGL 843

Query: 178 GVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECE 237
           GV++Y ++ G  PF G   + +   +++ + R P F+ST                  E  
Sbjct: 844 GVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLST------------------EAI 885

Query: 238 HLIRHMLVLDPNKRL-----SMEQICKHKWMKLGDADPNFDRLI 276
            ++R +L  +P +RL       E + KH + +L D     D+ +
Sbjct: 886 SIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKV 929



>gi|38502964|sp|Q86V86|PIM3_HUMAN   Serine/threonine-protein kinase Pim-3
          Length = 326

 Score =  107 bits (268), Expect = 2e-23
 Identities = 73/213 (34%), Positives = 102/213 (47%), Gaps = 27/213 (12%)

Query: 53  IIRLYQVMETERMIYLVTEYASGGE-IFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 111
           +IRL    E      LV E     + +FD +   G + E  ARR F Q++ AV  CH   
Sbjct: 106 VIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCG 165

Query: 112 IVHRDLKAENLLLDANL-NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP 170
           +VHRD+K ENLL+D     +K+ DFG S       +   + G+  Y+ PE      Y G 
Sbjct: 166 VVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGR 224

Query: 171 KVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGC 230
              +WSLGV+LY +VCG +PF+    + LR R+L  +   P                   
Sbjct: 225 SATVWSLGVLLYDMVCGDIPFEQDE-EILRGRLLFRRRVSP------------------- 264

Query: 231 LSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263
               EC+ LIR  L L P++R S++QI  H WM
Sbjct: 265 ----ECQQLIRWCLSLRPSERPSLDQIAAHPWM 293



>gi|54041234|sp|P23443|KS6B1_HUMAN   Ribosomal protein S6 kinase 1 (S6K) (S6K1) (70 kDa ribosomal
           protein S6 kinase 1) (p70 S6 kinase alpha)
           (p70(S6K)-alpha) (p70-S6K) (p70-alpha)
          Length = 525

 Score =  107 bits (267), Expect = 3e-23
 Identities = 67/220 (30%), Positives = 112/220 (50%), Gaps = 4/220 (1%)

Query: 16  TKQLVAIKIIDKTQL--DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           T ++ A+K++ K  +  + ++      E  I++ + HP I+ L    +T   +YL+ EY 
Sbjct: 116 TGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYL 175

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
           SGGE+F  L   G   E  A     +I  A+   H + I++RDLK EN++L+   ++K+ 
Sbjct: 176 SGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLT 235

Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           DFG        G +  T+CG+  Y APE+     ++   VD WSLG ++Y ++ GA PF 
Sbjct: 236 DFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHN-RAVDWWSLGALMYDMLTGAPPFT 294

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLS 232
           G   +    ++L  K  +P +++      L K LK    S
Sbjct: 295 GENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAAS 334



>gi|14423909|sp|O94768|ST17B_HUMAN   Serine/threonine-protein kinase 17B (DAP kinase-related
           apoptosis-inducing protein kinase 2)
          Length = 372

 Score =  107 bits (266), Expect = 4e-23
 Identities = 79/268 (29%), Positives = 127/268 (47%), Gaps = 27/268 (10%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH-PHIIRLYQVMETERMIYLVTEY 72
           + T Q  A K + K +  ++   +I  E+ ++++    P +I L++V E    I L+ EY
Sbjct: 53  KSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEY 112

Query: 73  ASGGEIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL-- 128
           A+GGEIF   +      ++E +  R  KQI+  VY+ H  NIVH DLK +N+LL +    
Sbjct: 113 AAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPL 172

Query: 129 -NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLV 185
            +IKI DFG S        L+   G+P Y APE+     YD      D+W++G++ Y+L+
Sbjct: 173 GDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL---NYDPITTATDMWNIGIIAYMLL 229

Query: 186 CGALPFDGSTLQNLRARVLSGKFRIPFFMST-GLVPELDKRLKAGCLSIAECEHLIRHML 244
               PF G   Q     +   +  + +   T   V +L                 I+ +L
Sbjct: 230 THTSPFVGEDNQETYLNI--SQVNVDYSEETFSSVSQL-------------ATDFIQSLL 274

Query: 245 VLDPNKRLSMEQICKHKWMKLGDADPNF 272
           V +P KR + E    H W++  D +  F
Sbjct: 275 VKNPEKRPTAEICLSHSWLQQWDFENLF 302



>gi|12643872|sp|Q9UBS0|KS6B2_HUMAN   Ribosomal protein S6 kinase 2 (S6K2) (70 kDa ribosomal protein S6
           kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70
           S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6
           kinase-related kinase) (SRK) (Serine/threonine-protein
           kinase 14 beta)
          Length = 482

 Score =  107 bits (266), Expect = 4e-23
 Identities = 63/213 (29%), Positives = 111/213 (52%), Gaps = 4/213 (1%)

Query: 18  QLVAIKIIDKTQL--DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           ++ A+K++ K ++  + ++      E  I++ + HP I+ L    +T   +YL+ E  SG
Sbjct: 94  KIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSG 153

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           GE+F HL   G   E  A     +I  A+   H + I++RDLK EN++L +  +IK+ DF
Sbjct: 154 GELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDF 213

Query: 136 GF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194
           G        G +  T+CG+  Y APE+     ++   VD WSLG ++Y ++ G+ PF   
Sbjct: 214 GLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHN-RAVDWWSLGALMYDMLTGSPPFTAE 272

Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLK 227
             +    +++ GK  +P +++      + K LK
Sbjct: 273 NRKKTMDKIIRGKLALPPYLTPDARDLVKKFLK 305



>gi|125565|sp|P11309|PIM1_HUMAN   Proto-oncogene serine/threonine-protein kinase Pim-1
          Length = 313

 Score =  106 bits (265), Expect = 5e-23
 Identities = 78/253 (30%), Positives = 125/253 (49%), Gaps = 33/253 (13%)

Query: 20  VAIKIIDKTQLDE----ENLKKIFREVQIMKMLCHPH--IIRLYQVMETERMIYLVTEYA 73
           VAIK ++K ++ +     N  ++  EV ++K +      +IRL    E      L+ E  
Sbjct: 64  VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123

Query: 74  SG-GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL-NIK 131
               ++FD +   G + E+ AR  F Q++ AV  CH   ++HRD+K EN+L+D N   +K
Sbjct: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183

Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           + DFG S       +   + G+  Y+ PE      Y G    +WSLG++LY +VCG +PF
Sbjct: 184 LIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
           +    + +R +V    FR              +R+       +EC+HLIR  L L P+ R
Sbjct: 243 EHDE-EIIRGQVF---FR--------------QRVS------SECQHLIRWCLALRPSDR 278

Query: 252 LSMEQICKHKWMK 264
            + E+I  H WM+
Sbjct: 279 PTFEEIQNHPWMQ 291



>gi|47117818|sp|O75914|PAK3_HUMAN   Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
           (PAK-3) (Beta-PAK) (Oligophrenin-3)
          Length = 559

 Score =  106 bits (264), Expect = 6e-23
 Identities = 74/251 (29%), Positives = 128/251 (50%), Gaps = 20/251 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T Q VAIK ++  Q  ++ L  I  E+ +M+   +P+I+           +++V EY +G
Sbjct: 305 TGQEVAIKQMNLQQQPKKEL--IINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG 362

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           G + D +V    M E +     ++ + A+ F H   ++HRD+K++N+LL  + ++K+ DF
Sbjct: 363 GSLTD-VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDF 421

Query: 136 GFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGS 194
           GF    TP Q  + T  G+P + APE+   K Y GPKVDIWSLG++   +V G  P+   
Sbjct: 422 GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPKVDIWSLGIMAIEMVEGEPPY--- 477

Query: 195 TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSM 254
                   +     R  + ++T   PEL    +      A     +   L +D ++R S 
Sbjct: 478 --------LNENPLRALYLIATNGTPELQNPERLS----AVFRDFLNRCLEMDVDRRGSA 525

Query: 255 EQICKHKWMKL 265
           +++ +H ++KL
Sbjct: 526 KELLQHPFLKL 536



>gi|8928460|sp|O75962|TRIO_HUMAN   Triple functional domain protein (PTPRF interacting protein)
          Length = 3038

 Score =  105 bits (262), Expect = 1e-22
 Identities = 77/283 (27%), Positives = 129/283 (45%), Gaps = 25/283 (8%)

Query: 16   TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
            TK+ VA K ++K  +  +   ++  E+ I++ L HP ++ L    ET     LV E A  
Sbjct: 2759 TKRAVATKFVNKKLMKRD---QVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQ 2815

Query: 76   GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKI 132
            G + D +V  G + E + R    +++ AV + H   I H DLK EN+L+D +L    IK+
Sbjct: 2816 GRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKL 2875

Query: 133  ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
            ADFG +        +    G+P +AAPE+  G        D WS+GV+ YVL+ G  PF 
Sbjct: 2876 ADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTS-DTWSVGVLTYVLLSGVSPFL 2934

Query: 193  GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
              +++     +    F  P     G+                + +  +  +L  DP KR 
Sbjct: 2935 DDSVEETCLNICRLDFSFPDDYFKGV--------------SQKAKEFVCFLLQEDPAKRP 2980

Query: 253  SMEQICKHKWMKLGDADP----NFDRLIAECQQLKEERQVDPL 291
            S     + +W++ G+       +  RL +  ++ K +  V P+
Sbjct: 2981 SAALALQEQWLQAGNGRSTGVLDTSRLTSFIERRKHQNDVRPI 3023



>gi|20139243|sp|Q9P1W9|PIM2_HUMAN   Serine/threonine-protein kinase Pim-2 (Pim-2h)
          Length = 311

 Score =  104 bits (259), Expect = 2e-22
 Identities = 67/217 (30%), Positives = 101/217 (46%), Gaps = 27/217 (12%)

Query: 50  HPHIIRLYQVMETERMIYLVTEYA-SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH 108
           HP +IRL    ET+    LV E      ++FD++   G + E  +R  F Q+V A+  CH
Sbjct: 96  HPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCH 155

Query: 109 CRNIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY 167
            R +VHRD+K EN+L+D      K+ DFG S      +    + G+  Y+ PE     +Y
Sbjct: 156 SRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPPEWISRHQY 214

Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLK 227
                 +WSLG++LY +VCG +PF+          +L  +   P  +S            
Sbjct: 215 HALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVS------------ 256

Query: 228 AGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
                  +C  LIR  L   P+ R S+E+I    WM+
Sbjct: 257 ------PDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 287



>gi|28558163|sp|Q96BR1|SGK3_HUMAN   Serine/threonine-protein kinase Sgk3 (Serum/glucocorticoid
           regulated kinase 3) (Serum/glucocorticoid regulated
           kinase-like)
          Length = 496

 Score =  104 bits (259), Expect = 2e-22
 Identities = 61/174 (35%), Positives = 94/174 (54%), Gaps = 4/174 (2%)

Query: 21  AIKIIDKT-QLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78
           A+K++ K   L+ +  K I  E  ++ K + HP ++ L+   +T   +Y V ++ +GGE+
Sbjct: 189 AVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGEL 248

Query: 79  FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF- 137
           F HL       E  AR    +I +A+ + H   IV+RDLK EN+LLD+  ++ + DFG  
Sbjct: 249 FFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLC 308

Query: 138 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
                      T+CG+P Y APE+   + YD   VD W LG VLY ++ G  PF
Sbjct: 309 KEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN-TVDWWCLGAVLYEMLYGLPPF 361



>gi|47605999|sp|Q13464|ROCK1_HUMAN   Rho-associated protein kinase 1 (Rho-associated, coiled-coil
           containing protein kinase 1) (p160 ROCK-1) (p160ROCK)
          Length = 1354

 Score =  103 bits (257), Expect = 4e-22
 Identities = 60/205 (29%), Positives = 115/205 (56%), Gaps = 7/205 (3%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           + T+++ A+K++ K ++ + +    F  E  IM     P +++L+   + +R +Y+V EY
Sbjct: 96  KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEY 155

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
             GG++ + L+++  + EK AR    ++V A+   H    +HRD+K +N+LLD + ++K+
Sbjct: 156 MPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKL 214

Query: 133 ADFGFSNLFTPGQLLK--TWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCG 187
           ADFG         +++  T  G+P Y +PE+ +   G  Y G + D WS+GV LY ++ G
Sbjct: 215 ADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVG 274

Query: 188 ALPFDGSTLQNLRARVLSGKFRIPF 212
             PF   +L    +++++ K  + F
Sbjct: 275 DTPFYADSLVGTYSKIMNHKNSLTF 299



>gi|13626607|sp|Q9Y6E0|STK24_HUMAN   Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
           (Mammalian STE20-like protein kinase 3)
          Length = 443

 Score =  102 bits (254), Expect = 9e-22
 Identities = 82/321 (25%), Positives = 149/321 (46%), Gaps = 34/321 (10%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G + +     T+++VAIKIID  + ++E ++ I +E+ ++     P++ + Y     +  
Sbjct: 48  GEVFKGIDNRTQKVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKDTK 106

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125
           ++++ EY  GG   D L+  G + E +     ++I+  + + H    +HRD+KA N+LL 
Sbjct: 107 LWIIMEYLGGGSALD-LLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS 165

Query: 126 ANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184
            +  +K+ADFG +   T  Q+ + T+ G+P + APE+ +   YD  K DIWSLG+    L
Sbjct: 166 EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS-KADIWSLGITAIEL 224

Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244
             G  P   S L  ++       F IP      L     K LK            +   L
Sbjct: 225 ARGEPPH--SELHPMKV-----LFLIPKNNPPTLEGNYSKPLK----------EFVEACL 267

Query: 245 VLDPNKRLSMEQICKHKWMKLGDADPNF-DRLIAECQQLKEERQVDPLNEDVLLAMEDMG 303
             +P+ R + +++ KHK++       ++   LI   ++ K E+  D  + +         
Sbjct: 268 NKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSE--------- 318

Query: 304 LDKEQTLQPDGTLNLDSDEGE 324
              +   + DG  +  SD G+
Sbjct: 319 ---DSDAETDGQASGGSDSGD 336



>gi|12643529|sp|O00506|STK25_HUMAN   Serine/threonine-protein kinase 25 (Sterile 20/oxidant
           stress-response kinase 1) (Ste20/oxidant stress response
           kinase-1) (SOK-1) (Ste20-like kinase)
          Length = 426

 Score =  102 bits (254), Expect = 9e-22
 Identities = 75/259 (28%), Positives = 124/259 (47%), Gaps = 21/259 (8%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G + +     TK++VAIKIID  + ++E ++ I +E+ ++     P+I R +        
Sbjct: 32  GEVYKGIDNHTKEVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYITRYFGSYLKSTK 90

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125
           ++++ EY  GG   D L+  G + E       ++I+  + + H    +HRD+KA N+LL 
Sbjct: 91  LWIIMEYLGGGSALD-LLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLS 149

Query: 126 ANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVL 184
              ++K+ADFG +   T  Q+ + T+ G+P + APE+ +   YD  K DIWSLG+    L
Sbjct: 150 EQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF-KADIWSLGITAIEL 208

Query: 185 VCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244
             G  P   S L  +R   L  K   P        P   K     CL+            
Sbjct: 209 AKGEPP--NSDLHPMRVLFLIPKNSPPTLEGQHSKP--FKEFVEACLN------------ 252

Query: 245 VLDPNKRLSMEQICKHKWM 263
             DP  R + +++ KHK++
Sbjct: 253 -KDPRFRPTAKELLKHKFI 270



>gi|6174910|sp|Q16512|PKL1_HUMAN   Protein kinase N1 (Protein kinase C-like 1) (Protein-kinase
           C-related kinase 1) (Protein kinase C-like PKN)
           (Serine-threonine protein kinase N)
          Length = 942

 Score =  102 bits (254), Expect = 9e-22
 Identities = 72/256 (28%), Positives = 123/256 (48%), Gaps = 25/256 (9%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLC---HPHIIRLYQVME 61
           G ++    + + +L AIK + K  +   + ++ +  E +I+  +    HP ++ L+   +
Sbjct: 627 GKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQ 686

Query: 62  TERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121
           T   +  V EY++GG++  H+ +    +E  A      +V  + F H   IV+RDLK +N
Sbjct: 687 TPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDN 745

Query: 122 LLLDANLNIKIADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV 180
           LLLD    +KIADFG        G    T+CG+P + APE+     Y    VD W LGV+
Sbjct: 746 LLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYT-RAVDWWGLGVL 804

Query: 181 LYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLI 240
           LY ++ G  PF G   + +   +++ + R P F+S                  AE   ++
Sbjct: 805 LYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLS------------------AEAIGIM 846

Query: 241 RHMLVLDPNKRLSMEQ 256
           R +L  +P +RL   +
Sbjct: 847 RRLLRRNPERRLGSSE 862



>gi|547803|sp|Q05655|KPCD_HUMAN   Protein kinase C, delta type (nPKC-delta)
          Length = 676

 Score =  102 bits (254), Expect = 9e-22
 Identities = 62/192 (32%), Positives = 107/192 (55%), Gaps = 6/192 (3%)

Query: 6   GYIIQDFLQETKQLVAIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63
           G ++   L+   +  AIK + K   L +++++    E +++ +   +P +  L    +T+
Sbjct: 361 GKVLLGELKGRGEYSAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK 420

Query: 64  RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123
             ++ V E+ +GG++  H+   GR     A     +I+  + F H + I++RDLK +N+L
Sbjct: 421 DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL 480

Query: 124 LDANLNIKIADFGF--SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL 181
           LD + +IKIADFG    N+F   +   T+CG+P Y APE+ +G +Y    VD WS GV+L
Sbjct: 481 LDRDGHIKIADFGMCKENIFGESR-ASTFCGTPDYIAPEILQGLKYTF-SVDWWSFGVLL 538

Query: 182 YVLVCGALPFDG 193
           Y ++ G  PF G
Sbjct: 539 YEMLIGQSPFHG 550



>gi|30316125|sp|Q9HBH9|MKNK2_HUMAN   MAP kinase-interacting serine/threonine kinase 2 (MAP kinase
           signal-integrating kinase 2) (Mnk2)
          Length = 418

 Score =  102 bits (253), Expect = 1e-21
 Identities = 91/283 (32%), Positives = 130/283 (45%), Gaps = 53/283 (18%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T Q  A+KII+K      +  ++FREV+++ +   H +++ L +  E E   YLV E   
Sbjct: 59  TSQEYAVKIIEKQPGHIRS--RVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMR 116

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN---IK 131
           GG I  H+       E EA    + + +A+ F H + I HRDLK EN+L +       +K
Sbjct: 117 GGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVK 176

Query: 132 IADFGF----------SNLFTPGQLLKTWCGSPPYAAPELF-----EGKEYDGPKVDIWS 176
           I DF            S + TP   L T CGS  Y APE+      E   YD  + D+WS
Sbjct: 177 ICDFDLGSGIKLNGDCSPISTPE--LLTPCGSAEYMAPEVVEAFSEEASIYD-KRCDLWS 233

Query: 177 LGVVLYVLVCGALPFDG--------------STLQN-LRARVLSGKFRIPFFMSTGLVPE 221
           LGV+LY+L+ G  PF G                 QN L   +  GK+  P          
Sbjct: 234 LGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFP---------- 283

Query: 222 LDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
            DK      +S A  + LI  +LV D  +RLS  Q+ +H W++
Sbjct: 284 -DK--DWAHISCA-AKDLISKLLVRDAKQRLSAAQVLQHPWVQ 322



>gi|12585288|sp|O96013|PAK4_HUMAN   Serine/threonine-protein kinase PAK 4 (p21-activated kinase 4)
           (PAK-4)
          Length = 591

 Score =  100 bits (250), Expect = 3e-21
 Identities = 69/253 (27%), Positives = 129/253 (50%), Gaps = 22/253 (8%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           ++ + +LVA+K +D  +     L  +F EV IM+   H +++ +Y        +++V E+
Sbjct: 340 VRSSGKLVAVKKMDLRKQQRREL--LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEF 397

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
             GG + D +V H RM E++       ++ A+   H + ++HRD+K++++LL  +  +K+
Sbjct: 398 LEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKL 456

Query: 133 ADFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           +DFGF + +       K+  G+P + APEL     Y GP+VDIWSLG+++  +V G  P+
Sbjct: 457 SDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPY 515

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPE-LDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
                           F  P   +  ++ + L  RLK         +  +  +LV DP +
Sbjct: 516 ----------------FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 559

Query: 251 RLSMEQICKHKWM 263
           R +  ++ KH ++
Sbjct: 560 RATAAELLKHPFL 572



>gi|231726|sp|Q00526|CDK3_HUMAN   Cell division protein kinase 3
          Length = 305

 Score =  100 bits (248), Expect = 5e-21
 Identities = 82/285 (28%), Positives = 134/285 (47%), Gaps = 43/285 (15%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           +ET QLVA+K I +  L+ E +     RE+ ++K L HP+I+RL  V+  ER +YLV E+
Sbjct: 24  RETGQLVALKKI-RLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEF 82

Query: 73  AS-----------GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121
            S           G E+  HL+          +    Q++  V FCH   ++HRDLK +N
Sbjct: 83  LSQDLKKYMDSTPGSELPLHLI----------KSYLFQLLQGVSFCHSHRVIHRDLKPQN 132

Query: 122 LLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPP---YAAPELFEGKEYDGPKVDIWSLG 178
           LL++    IK+ADFG +  F  G  L+T+        Y APE+  G ++    VDIWS+G
Sbjct: 133 LLINELGAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIG 190

Query: 179 VVLYVLVCGALPFDGSTLQNLRARVL-----------SGKFRIPFFMSTGLVPELDKRLK 227
            +   +V     F G +  +   R+             G  ++P +   G  P+  ++  
Sbjct: 191 CIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDY--KGSFPKWTRKGL 248

Query: 228 AGCLSIAECE--HLIRHMLVLDPNKRLSMEQICKHKWMKLGDADP 270
              +   E E   L+  +L  DP++R++ +    H +    +  P
Sbjct: 249 EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSP 293



>gi|20178297|sp|P51956|NEK3_HUMAN   Serine/threonine-protein kinase Nek3 (NimA-related protein kinase
           3) (HSPK 36)
          Length = 506

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 5/196 (2%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           + + Q+ A+K I +      N +   +E  ++  + HP+I+   +  E E  +Y+V EY 
Sbjct: 24  ESSNQMFAMKEI-RLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYC 82

Query: 74  SGGEIFDHLVAH-GRM-AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
            GG++   +    G++  E      F Q+   V   H + ++HRD+K++N+ L  N  +K
Sbjct: 83  DGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVK 142

Query: 132 IADFGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           + DFG + L + P     T+ G+P Y  PE++E   Y+  K DIWSLG +LY L     P
Sbjct: 143 LGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNN-KSDIWSLGCILYELCTLKHP 201

Query: 191 FDGSTLQNLRARVLSG 206
           F  ++ +NL  +V  G
Sbjct: 202 FQANSWKNLILKVCQG 217



>gi|12585290|sp|Q9P286|PAK7_HUMAN   Serine/threonine-protein kinase PAK 7 (p21-activated kinase 7)
           (PAK-7) (PAK-5)
          Length = 719

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 69/254 (27%), Positives = 131/254 (51%), Gaps = 22/254 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           + T + VA+K +D  +     L  +F EV IM+   H +++ +Y        +++V E+ 
Sbjct: 469 KHTGKQVAVKKMDLRKQQRREL--LFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFL 526

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
            GG + D +V H RM E++       ++ A+ + H + ++HRD+K++++LL ++  IK++
Sbjct: 527 EGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585

Query: 134 DFGF-SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP-F 191
           DFGF + +       K+  G+P + APE+     Y G +VDIWSLG+++  ++ G  P F
Sbjct: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWSLGIMVIEMIDGEPPYF 644

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
           +   LQ +R             +   L P +    K   +        +  MLV +P++R
Sbjct: 645 NEPPLQAMRR------------IRDSLPPRVKDLHKVSSV----LRGFLDLMLVREPSQR 688

Query: 252 LSMEQICKHKWMKL 265
            + +++  H ++KL
Sbjct: 689 ATAQELLGHPFLKL 702



>gi|6175070|sp|O76039|CDKL5_HUMAN   Serine/threonine-protein kinase 9 (Cyclin-dependent kinase-like 5)
          Length = 1030

 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 79/274 (28%), Positives = 135/274 (49%), Gaps = 23/274 (8%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G +++   +ET ++VAIK    ++ +EE  +   RE+++++ L   +I+ L +       
Sbjct: 25  GVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGK 84

Query: 66  IYLVTEYASGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123
           +YLV EY      E+ + +  +G   EK  +    Q++ A+++CH  +IVHRD+K ENLL
Sbjct: 85  LYLVFEYVEKNMLELLEEM-PNGVPPEK-VKSYIYQLIKAIHWCHKNDIVHRDIKPENLL 142

Query: 124 LDANLNIKIADFGFSNLFTPGQLLK--TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL 181
           +  N  +K+ DFGF+   + G       +  +  Y +PEL  G  Y G  VD+WS+G +L
Sbjct: 143 ISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPY-GKSVDMWSVGCIL 201

Query: 182 YVLVCGALPFDGS-------TLQNLRARVLSGKFRI----PFFMSTGLV----PELDKRL 226
             L  G   F G        T+Q +   + S + ++    P F          P+  +R 
Sbjct: 202 GELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERR 261

Query: 227 KAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKH 260
             G L+    + L++++L LDP  R   EQ   H
Sbjct: 262 YLGILNSVLLD-LMKNLLKLDPADRYLTEQCLNH 294



>gi|1705489|sp|P51813|BMX_HUMAN   Cytoplasmic tyrosine-protein kinase BMX (Bone marrow tyrosine
           kinase gene in chromosome X protein) (Epithelial and
           endothelial tyrosine kinase) (ETK) (NTK38)
          Length = 675

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 71/270 (26%), Positives = 127/270 (47%), Gaps = 43/270 (15%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K+I +  + E+   + F+E Q M  L HP +++ Y V   E  IY+VTEY S G + 
Sbjct: 442 VAVKMIKEGSMSED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLL 498

Query: 80  DHLVAHGRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
           ++L +HG+  E  +       +   + F      +HRDL A N L+D +L +K++DFG +
Sbjct: 499 NYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMT 558

Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195
                 Q + +     P  ++APE+F   +Y   K D+W+ G++++ V   G  P+D   
Sbjct: 559 RYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSS-KSDVWAFGILMWEVFSLGKQPYD--- 614

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSME 255
                            + ++ +V           L +++   L R  L  D     ++ 
Sbjct: 615 ----------------LYDNSQVV-----------LKVSQGHRLYRPHLASD-----TIY 642

Query: 256 QICKHKWMKLGDADPNFDRLIAECQQLKEE 285
           QI    W +L +  P F +L++  + L+E+
Sbjct: 643 QIMYSCWHELPEKRPTFQQLLSSIEPLREK 672



>gi|47605963|sp|O75116|ROCK2_HUMAN   Rho-associated protein kinase 2 (Rho-associated, coiled-coil
           containing protein kinase 2) (p164 ROCK-2) (Rho kinase
           2)
          Length = 1388

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 57/203 (28%), Positives = 113/203 (55%), Gaps = 7/203 (3%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           ++++ A+K++ K ++ + +    F  E  IM     P +++L+   + +R +Y+V EY  
Sbjct: 114 SQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMP 173

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GG++ + L+++  + EK A+    ++V A+   H   ++HRD+K +N+LLD + ++K+AD
Sbjct: 174 GGDLVN-LMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLAD 232

Query: 135 FGFSNLFTPGQLL--KTWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVCGAL 189
           FG         ++   T  G+P Y +PE+ +   G  + G + D WS+GV LY ++ G  
Sbjct: 233 FGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDT 292

Query: 190 PFDGSTLQNLRARVLSGKFRIPF 212
           PF   +L    ++++  K  + F
Sbjct: 293 PFYADSLVGTYSKIMDHKNSLCF 315



>gi|34098605|sp|Q8TD19|NEK9_HUMAN   Serine/threonine-protein kinase Nek9 (NimA-related protein kinase
           9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8)
          Length = 979

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 61/195 (31%), Positives = 104/195 (53%), Gaps = 4/195 (2%)

Query: 15  ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           E   LV  K +D T+L E+  +    E+ I+ +L H +II  Y        + +  EY +
Sbjct: 73  EDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCN 132

Query: 75  GGEIFDHLVAH-GRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
           GG ++D ++    ++ E+E    +  QIV+AV   H   I+HRD+K  N+ L     IK+
Sbjct: 133 GGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKL 192

Query: 133 ADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
            D+G +  L +   + +T  G+P Y +PEL +G +Y+  K DIW++G V++ L+     F
Sbjct: 193 GDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF-KSDIWAVGCVIFELLTLKRTF 251

Query: 192 DGSTLQNLRARVLSG 206
           D +   NL  +++ G
Sbjct: 252 DATNPLNLCVKIVQG 266



>gi|2499640|sp|Q99759|M3K3_HUMAN   Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
           kinase 3) (MEK kinase 3) (MEKK 3)
          Length = 626

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 51/157 (32%), Positives = 87/157 (55%), Gaps = 7/157 (4%)

Query: 41  EVQIMKMLCHPHIIRLYQVME--TERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK 98
           E+Q++K L H  I++ Y  +    E+ + +  EY  GG + D L A+G + E   R+  +
Sbjct: 412 EIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR 471

Query: 99  QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS----NLFTPGQLLKTWCGSP 154
           QI+  + + H   IVHRD+K  N+L D+  N+K+ DFG S     +   G  +++  G+P
Sbjct: 472 QILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTP 531

Query: 155 PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
            + +PE+  G+ Y G K D+WSLG  +  ++    P+
Sbjct: 532 YWMSPEVISGEGY-GRKADVWSLGCTVVEMLTEKPPW 567



>gi|4033704|sp|Q00535|CDK5_HUMAN   Cell division protein kinase 5 (Tau protein kinase II catalytic
           subunit) (TPKII catalytic subunit)
           (Serine/threonine-protein kinase PSSALRE)
          Length = 292

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 66/264 (25%), Positives = 126/264 (47%), Gaps = 17/264 (6%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           +ET ++VA+K +     DE       RE+ ++K L H +I+RL+ V+ +++ + LV E+ 
Sbjct: 24  RETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFC 83

Query: 74  SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
                + FD    +G +  +  +    Q++  + FCH RN++HRDLK +NLL++ N  +K
Sbjct: 84  DQDLKKYFDS--CNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELK 141

Query: 132 IADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           +ADFG +  F  P +       +  Y  P++  G +     +D+WS G +   L     P
Sbjct: 142 LADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRP 201

Query: 191 -FDGSTLQNLRARVL-----------SGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH 238
            F G+ + +   R+                ++P +    + P     +       A    
Sbjct: 202 LFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRD 261

Query: 239 LIRHMLVLDPNKRLSMEQICKHKW 262
           L++++L  +P +R+S E+  +H +
Sbjct: 262 LLQNLLKCNPVQRISAEEALQHPY 285



>gi|115922|sp|P06493|CDC2_HUMAN   Cell division control protein 2 homolog (p34 protein kinase)
           (Cyclin-dependent kinase 1) (CDK1)
          Length = 297

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 76/275 (27%), Positives = 126/275 (45%), Gaps = 22/275 (8%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G + +   + T Q+VA+K I     +E       RE+ ++K L HP+I+ L  V+  +  
Sbjct: 16  GVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSR 75

Query: 66  IYLVTEYASGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLL 123
           +YL+ E+ S    +  D +     M     +    QI+  + FCH R ++HRDLK +NLL
Sbjct: 76  LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLL 135

Query: 124 LDANLNIKIADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182
           +D    IK+ADFG +  F  P ++      +  Y +PE+  G       VDIWS+G +  
Sbjct: 136 IDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFA 195

Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDK---------RLKAGCLS- 232
            L      F G +  +   R+    FR     +  + PE++          + K G L+ 
Sbjct: 196 ELATKKPLFHGDSEIDQLFRI----FRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS 251

Query: 233 -IAECEH----LIRHMLVLDPNKRLSMEQICKHKW 262
            +   +     L+  ML+ DP KR+S +    H +
Sbjct: 252 HVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286



>gi|6685620|sp|Q9Y2U5|M3K2_HUMAN   Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
           kinase 2) (MEK kinase 2) (MEKK 2)
          Length = 618

 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 51/157 (32%), Positives = 86/157 (54%), Gaps = 7/157 (4%)

Query: 41  EVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK 98
           E+Q++K   H  I++ Y  +    E+ + +  EY  GG I D L A+G + E   R+  +
Sbjct: 405 EIQLLKNFLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTR 464

Query: 99  QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS----NLFTPGQLLKTWCGSP 154
           QI+  V++ H   I+HRD+K  N+L D+  N+K+ DFG S     +   G  +K+  G+P
Sbjct: 465 QILEGVHYLHSNMILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTP 524

Query: 155 PYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
            + +PE+  G+ Y G K DIWS+   +  ++    P+
Sbjct: 525 YWMSPEVISGQGY-GRKADIWSVACTVVEMLTEKPPW 560



>gi|6685621|sp|Q9Y6R4|M3K4_HUMAN   Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
            kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1)
          Length = 1607

 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 76/259 (29%), Positives = 122/259 (47%), Gaps = 27/259 (10%)

Query: 15   ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
            +T +L+A+K I     D + +K+   E++I + + HP+++R + V      +Y+  EY  
Sbjct: 1363 DTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCD 1422

Query: 75   GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
             G + +  V+   + E   R   KQI  A+   H   IVHRD+K  N+ L ++  IK+ D
Sbjct: 1423 EGTLEE--VSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD 1480

Query: 135  FGFS-----NLFT-PGQLLKTWCGSPPYAAPELFEGK--EYDGPKVDIWSLGVVLYVLVC 186
            FG S     N  T PG++  T  G+  Y APE+      E  G   DIWSLG V+  +V 
Sbjct: 1481 FGCSVKLKNNAQTMPGEVNST-LGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT 1539

Query: 187  GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246
            G  P+                F+I + +  G  P + +RL        E +  + H L  
Sbjct: 1540 GKRPW----------HEYEHNFQIMYKVGMGHKPPIPERLS------PEGKDFLSHCLES 1583

Query: 247  DPNKRLSMEQICKHKWMKL 265
            DP  R +  Q+  H ++K+
Sbjct: 1584 DPKMRWTASQLLDHSFVKV 1602



>gi|12643825|sp|Q9NYV4|CD2L7_HUMAN   Cell division cycle 2-related protein kinase 7 (CDC2-related protein
            kinase 7) (CrkRS)
          Length = 1490

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 77/290 (26%), Positives = 135/290 (46%), Gaps = 54/290 (18%)

Query: 14   QETKQLVAIKIIDKTQLDEENLK---KIFREVQIMKMLCHPHIIRLYQVMETER------ 64
            ++T +LVA+K   K +LD E         RE++I++ L H  ++ + +++  ++      
Sbjct: 747  KDTGELVALK---KVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFK 803

Query: 65   ----MIYLVTEYASGGEIFDH----LVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVH 114
                  YLV EY       DH    L+  G    +E   +   KQ++  + +CH +N +H
Sbjct: 804  KDKGAFYLVFEY------MDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLH 857

Query: 115  RDLKAENLLLDANLNIKIADFGFSNLFT-------PGQLLKTWCGSPPYAAPELFEGKEY 167
            RD+K  N+LL+ +  IK+ADFG + L+          +++  W     Y  PEL  G+E 
Sbjct: 858  RDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW-----YRPPELLLGEER 912

Query: 168  DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLS------------GKFRIPFFMS 215
              P +D+WS G +L  L     P   + L+  +  ++S               ++P+F +
Sbjct: 913  YTPAIDVWSCGCILGELFT-KKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNT 971

Query: 216  TGLVPELDKRLKAGCLSIAECE-HLIRHMLVLDPNKRLSMEQICKHKWMK 264
                 +  +RL+     I      L+ HML LDP+KR + EQ  +  ++K
Sbjct: 972  MKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 1021



>gi|3915762|sp|P53667|LIK1_HUMAN   LIM domain kinase 1 (LIMK-1)
          Length = 647

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 19/196 (9%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G  I+   +ET +++ +K  +  + DEE  +   +EV++M+ L HP++++   V+  ++ 
Sbjct: 351 GQAIKVTHRETGEVMVMK--ELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKR 408

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLL 124
           +  +TEY  GG +   + +         R  F K I + + + H  NI+HRDL + N L+
Sbjct: 409 LNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLV 468

Query: 125 DANLNIKIADFGFSNLF----TPGQLLK-----------TWCGSPPYAAPELFEGKEYDG 169
             N N+ +ADFG + L     T  + L+           T  G+P + APE+  G+ YD 
Sbjct: 469 RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYD- 527

Query: 170 PKVDIWSLGVVLYVLV 185
            KVD++S G+VL  ++
Sbjct: 528 EKVDVFSFGIVLCEII 543



>gi|116051|sp|P24941|CDK2_HUMAN   Cell division protein kinase 2 (p33 protein kinase)
          Length = 298

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 79/274 (28%), Positives = 122/274 (44%), Gaps = 37/274 (13%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T ++VA+K I      E       RE+ ++K L HP+I++L  V+ TE  +YLV E+   
Sbjct: 26  TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ 85

Query: 76  G-EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
             + F    A   +     +    Q++  + FCH   ++HRDLK +NLL++    IK+AD
Sbjct: 86  DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLAD 145

Query: 135 FGFSNLFTPGQLLKTWCGSPP---YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           FG +  F  G  ++T+        Y APE+  G +Y    VDIWSLG +   +V     F
Sbjct: 146 FGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALF 203

Query: 192 DGS-----------TLQNLRARVLSGKFRIPFFMS----------TGLVPELDKRLKAGC 230
            G            TL      V  G   +P +            + +VP LD+      
Sbjct: 204 PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDE------ 257

Query: 231 LSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
               +   L+  ML  DPNKR+S +    H + +
Sbjct: 258 ----DGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287



>gi|1709347|sp|P51957|NEK4_HUMAN   Serine/threonine-protein kinase Nek4 (NimA-related protein kinase
           4) (Serine/threonine-protein kinase 2)
           (Serine/threonine-protein kinase NRK2)
          Length = 841

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 71/255 (27%), Positives = 119/255 (46%), Gaps = 23/255 (9%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET-ERMIYLVTEY 72
           ++ KQ V IK ++         +   +E Q++  L HP+I+   +  E  + ++Y+V  +
Sbjct: 27  RDGKQYV-IKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGF 85

Query: 73  ASGGEIFDHLVAHGR--MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130
             GG+++  L       + E +    F QI  A+ + H ++I+HRDLK +N+ L     I
Sbjct: 86  CEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNII 145

Query: 131 KIADFGFSN-LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           K+ D G +  L     +  T  G+P Y +PELF  K Y+  K D+W+LG  +Y +     
Sbjct: 146 KVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYN-YKSDVWALGCCVYEMATLKH 204

Query: 190 PFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPN 249
            F+   + +L  R++ GK      M     PEL                LIR ML   P 
Sbjct: 205 AFNAKDMNSLVYRIIEGKLPA---MPRDYSPEL--------------AELIRTMLSKRPE 247

Query: 250 KRLSMEQICKHKWMK 264
           +R S+  I +  ++K
Sbjct: 248 ERPSVRSILRQPYIK 262



>gi|23396789|sp|Q9NQU5|PAK6_HUMAN   Serine/threonine-protein kinase PAK 6 (p21-activated kinase 6)
           (PAK-6) (PAK-5)
          Length = 681

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 62/246 (25%), Positives = 126/246 (51%), Gaps = 22/246 (8%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K++D  +     L  +F EV IM+   H +++ +Y+       ++++ E+  GG + 
Sbjct: 433 VAVKMMDLRKQQRREL--LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALT 490

Query: 80  DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-S 138
           D +V+  R+ E++     + ++ A+ + H + ++HRD+K++++LL  +  +K++DFGF +
Sbjct: 491 D-IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCA 549

Query: 139 NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP-FDGSTLQ 197
            +       K+  G+P + APE+     Y   +VDIWSLG+++  +V G  P F  S +Q
Sbjct: 550 QISKDVPKRKSLVGTPYWMAPEVISRSLY-ATEVDIWSLGIMVIEMVDGEPPYFSDSPVQ 608

Query: 198 NLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQI 257
            ++             +     P+L    K   +        +  MLV DP +R + +++
Sbjct: 609 AMKR------------LRDSPPPKLKNSHKVSPV----LRDFLERMLVRDPQERATAQEL 652

Query: 258 CKHKWM 263
             H ++
Sbjct: 653 LDHPFL 658



>gi|46577700|sp|Q13188|STK3_HUMAN   Serine/threonine-protein kinase 3 (STE20-like kinase MST2) (MST-2)
           (Mammalian STE20-like protein kinase 2)
           (Serine/threonine-protein kinase Krs-1)
          Length = 491

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 76/305 (24%), Positives = 140/305 (45%), Gaps = 25/305 (8%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G + +   +E+ Q+VAIK +      E +L++I +E+ IM+    P++++ Y        
Sbjct: 39  GSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTD 94

Query: 66  IYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124
           +++V EY   G + D +    + + E E     K  +  + + H    +HRD+KA N+LL
Sbjct: 95  LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILL 154

Query: 125 DANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYV 183
           +   + K+ADFG +   T     + T  G+P + APE+ +   Y+    DIWSLG+    
Sbjct: 155 NTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN-CVADIWSLGITSIE 213

Query: 184 LVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHM 243
           +  G  P+  + +  +RA  +      P F      PEL            +    ++  
Sbjct: 214 MAEGKPPY--ADIHPMRAIFMIPTNPPPTFRK----PELWS---------DDFTDFVKKC 258

Query: 244 LVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMG 303
           LV +P +R +  Q+ +H ++K          LI E  ++K +R  +   E   L  E+  
Sbjct: 259 LVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRE---LEEEEEN 315

Query: 304 LDKEQ 308
            D+++
Sbjct: 316 SDEDE 320



>gi|56749668|sp|Q9Y2H1|ST38L_HUMAN   Serine/threonine-protein kinase 38-like (NDR2 protein kinase)
           (Nuclear Dbf2-related kinase 2)
          Length = 464

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 63/236 (26%), Positives = 112/236 (47%), Gaps = 38/236 (16%)

Query: 14  QETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           ++T  + A+KI+ K+  L++E +  I  E  I+       +++++   + +R +YL+ E+
Sbjct: 110 KDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEF 169

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
             GG++   L+    + E+E +    + V A+   H    +HRD+K +NLLLDA  ++K+
Sbjct: 170 LPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKL 229

Query: 133 ADFG--------------------------FSNLFTPG----------QLLKTWCGSPPY 156
           +DFG                          F N+ +            QL  +  G+P Y
Sbjct: 230 SDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDY 289

Query: 157 AAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 212
            APE+F    Y+    D WSLGV++Y ++ G  PF   T Q    +V++ K  + F
Sbjct: 290 IAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVF 344



>gi|13124559|sp|Q13043|STK4_HUMAN   Serine/threonine-protein kinase 4 (STE20-like kinase MST1) (MST-1)
           (Mammalian STE20-like protein kinase 1)
           (Serine/threonine-protein kinase Krs-2)
          Length = 487

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 73/284 (25%), Positives = 129/284 (45%), Gaps = 22/284 (7%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G + +   +ET Q+VAIK +      E +L++I +E+ IM+    PH+++ Y        
Sbjct: 42  GSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTD 97

Query: 66  IYLVTEYASGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124
           +++V EY   G + D +    + + E E     +  +  + + H    +HRD+KA N+LL
Sbjct: 98  LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILL 157

Query: 125 DANLNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYV 183
           +   + K+ADFG +   T     + T  G+P + APE+ +   Y+    DIWSLG+    
Sbjct: 158 NTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN-CVADIWSLGITAIE 216

Query: 184 LVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHM 243
           +  G  P+  + +  +RA  +      P F      PEL                 ++  
Sbjct: 217 MAEGKPPY--ADIHPMRAIFMIPTNPPPTFRK----PELWS---------DNFTDFVKQC 261

Query: 244 LVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQ 287
           LV  P +R +  Q+ +H +++          LI E   +K +RQ
Sbjct: 262 LVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQ 305



>gi|2833269|sp|Q15835|RK_HUMAN   Rhodopsin kinase (RK) (G protein-coupled receptor kinase 1)
          Length = 563

 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 81/257 (31%), Positives = 126/257 (49%), Gaps = 22/257 (8%)

Query: 13  LQETKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71
           ++ T +L A K ++K +L + +  +    E +I+  +    I+ L    ET+  + LV  
Sbjct: 209 MKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMT 268

Query: 72  YASGGEIFDHL--VAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDAN 127
             +GG+I  H+  V        E R  F   QI+  +   H R IV+RDLK EN+LLD +
Sbjct: 269 IMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDND 328

Query: 128 LNIKIADFGFSNLFTPGQ-LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC 186
            N++I+D G +     GQ   K + G+P + APEL +G+EYD   VD ++LGV LY ++ 
Sbjct: 329 GNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDF-SVDYFALGVTLYEMIA 387

Query: 187 GALPF--DGSTLQN--LRARVLSGKFRIP--------FFMSTGLVPELDKRLKAGCLSIA 234
              PF   G  ++N  L+ R++S   + P         F    L  + +KRL        
Sbjct: 388 ARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLG---FRDE 444

Query: 235 ECEHLIRHMLVLDPNKR 251
            C+ L  H L  D N R
Sbjct: 445 TCDKLRAHPLFKDLNWR 461



>gi|12643880|sp|Q9UEW8|STK39_HUMAN   STE20/SPS1-related proline-alanine rich protein kinase (Ste-20
           related kinase) (Serine/threonine-protein kinase 39)
           (DCHT)
          Length = 547

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 87/354 (24%), Positives = 151/354 (42%), Gaps = 41/354 (11%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           ++ VAIK I+  +  + ++ ++ +E+Q M    HP+++  Y     +  ++LV +  SGG
Sbjct: 88  QERVAIKRINLEKC-QTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGG 146

Query: 77  EIFD---HLVAHGR-----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL 128
            + D   ++V  G      + E       K+++  + + H    +HRDLKA N+LL  + 
Sbjct: 147 SMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDG 206

Query: 129 NIKIADFGFSNLFTPG------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182
           +++IADFG S     G      ++ KT+ G+P + APE+ E       K D+WS G+   
Sbjct: 207 SVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAI 266

Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRH 242
            L  GA P+       +    L      P  + TG V + +   K G         L+  
Sbjct: 267 ELATGAAPYHKYPPMKVLMLTLQND---PPTLETG-VEDKEMMKKYG----KSFRKLLSL 318

Query: 243 MLVLDPNKRLSMEQICKHK-WMKLGDADPNFDRLIAE----CQQLKEERQVDPLNEDVLL 297
            L  DP+KR +  ++ K K + K  + +   ++L+       Q+ K+ R+V         
Sbjct: 319 CLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVP-------- 370

Query: 298 AMEDMGLDKEQTLQPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEV 351
                G         DG      DE +E S E    +   +   V   +P   V
Sbjct: 371 -----GSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAV 419



>gi|1708824|sp|P53671|LIK2_HUMAN   LIM domain kinase 2 (LIMK-2)
          Length = 638

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 55/176 (31%), Positives = 89/176 (50%), Gaps = 22/176 (12%)

Query: 31  DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAE 90
           DEE  K    EV++M+ L HP++++   V+  ++ + L+TEY  GG + D L +      
Sbjct: 366 DEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPW 425

Query: 91  KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF--------- 141
           ++  R  K I + + + H   I+HRDL + N L+  +  + +ADFG S L          
Sbjct: 426 QQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPM 485

Query: 142 ----TPGQLLK--------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185
               T  + L+        T  G+P + APE+  GK YD   VDI+S G+VL  ++
Sbjct: 486 EKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYD-ETVDIFSFGIVLCEII 540



>gi|57015279|sp|O14578|CTRO_HUMAN   Citron Rho-interacting kinase (CRIK) (Rho-interacting,
           serine/threonine kinase 21)
          Length = 2027

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 72/272 (26%), Positives = 123/272 (45%), Gaps = 30/272 (11%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T  + A+K++ K  L  +     F E + I+     P I +L    + +  +YLV EY  
Sbjct: 119 TGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQP 178

Query: 75  GGEIFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
           GG++   L  +  ++ E   +    +++ AV+  H    VHRD+K EN+L+D   +IK+ 
Sbjct: 179 GGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLV 238

Query: 134 DFGFSNLFTPGQLL--KTWCGSPPYAAPELF-----EGKEYDGPKVDIWSLGVVLYVLVC 186
           DFG +      +++  K   G+P Y APE+      +GK   G   D WS+GV+ Y ++ 
Sbjct: 239 DFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIY 298

Query: 187 GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246
           G  PF   T     AR  +       F+     P+ D ++ +  L + +        L+ 
Sbjct: 299 GRSPFAEGT----SARTFNNIMNFQRFLK---FPD-DPKVSSDFLDLIQ-------SLLC 343

Query: 247 DPNKRLSMEQICKH------KWMKLGDADPNF 272
              +RL  E +C H       W  + ++ P F
Sbjct: 344 GQKERLKFEGLCCHPFFSKIDWNNIRNSPPPF 375



 Score = 37.7 bits (86), Expect = 0.028
 Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 13/120 (10%)

Query: 1163 KLREQLGPVTQEFWDNLEK----ETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMEL 1218
            KL EQL  ++ +  D+ +K    E E   +E+S + EE K +++  L + Q   QE  E 
Sbjct: 832  KLEEQLEKISHQ--DHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQER-ES 888

Query: 1219 YRQKVEPLRAELQEGARQKLHELQEKLSPLGEEM------RDRARAHVDALRTHLAPYSD 1272
                ++  RA L+   RQ   EL+E  +   EE+      RD  +   DALR      +D
Sbjct: 889  QLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD 948



>gi|10719935|sp|Q14004|CD2L5_HUMAN   Cell division cycle 2-like protein kinase 5 (CDC2-related protein
           kinase 5) (Cholinesterase-related cell division
           controller)
          Length = 418

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 77/296 (26%), Positives = 137/296 (46%), Gaps = 54/296 (18%)

Query: 14  QETKQLVAIKIIDKTQLDEENLK---KIFREVQIMKMLCHPHIIRLYQVMETER------ 64
           ++T ++VA+K   K +LD E         RE++I++ L H  II + +++  +       
Sbjct: 111 KDTGEMVALK---KVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFK 167

Query: 65  ----MIYLVTEYASGGEIFDH----LVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVH 114
                 YLV EY       DH    L+  G     E   +   +Q++  + +CH +N +H
Sbjct: 168 KDKGAFYLVFEY------MDHDLMGLLESGLVHFYENHIKSFMRQLMEGLDYCHKKNFLH 221

Query: 115 RDLKAENLLLDANLNIKIADFGFSNLFT-------PGQLLKTWCGSPPYAAPELFEGKEY 167
           RD+K  N+LL+    IK+ADFG + L++         +++  W     Y  PEL  G+E 
Sbjct: 222 RDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLW-----YRPPELLLGEER 276

Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGS---TLQNLRARVLSGK--------FRIPFFMST 216
             P +D+WS G +L  L      F  +       L +R+             ++P+F + 
Sbjct: 277 YTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTM 336

Query: 217 GLVPELDKRLKAGCLSI-AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPN 271
               +  ++L+   + I A    L  +ML LDP+KR + EQ  + ++++  D +P+
Sbjct: 337 KPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR--DVEPS 390



>gi|30316115|sp|Q9BUB5|MKNK1_HUMAN   MAP kinase-interacting serine/threonine kinase 1 (MAP kinase
           signal-integrating kinase 1) (Mnk1)
          Length = 465

 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 90/325 (27%), Positives = 132/325 (40%), Gaps = 91/325 (28%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVMETERMIYLVTE 71
           LQ  K+  A+KII+K      +  ++FREV+ + +   + +I+ L +  E +   YLV E
Sbjct: 69  LQNGKEY-AVKIIEKQA--GHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFE 125

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN-------------------- 111
              GG I  H+       E+EA R  + +  A+ F H ++                    
Sbjct: 126 KLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAA 185

Query: 112 ---------------------IVHRDLKAENLLLDANLNI---KIADFGF------SNLF 141
                                I HRDLK EN+L ++   +   KI DF        +N  
Sbjct: 186 PTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSC 245

Query: 142 TPGQL--LKTWCGSPPYAAPELFE-----GKEYDGPKVDIWSLGVVLYVLVCGALPFDG- 193
           TP     L T CGS  Y APE+ E        YD  + D+WSLGVVLY+++ G  PF G 
Sbjct: 246 TPITTPELTTPCGSAEYMAPEVVEVFTDQATFYD-KRCDLWSLGVVLYIMLSGYPPFVGH 304

Query: 194 -------------STLQN-LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL 239
                           QN L   +  GK+  P               K      +E + L
Sbjct: 305 CGADCGWDRGEVCRVCQNKLFESIQEGKYEFPD--------------KDWAHISSEAKDL 350

Query: 240 IRHMLVLDPNKRLSMEQICKHKWMK 264
           I  +LV D  +RLS  Q+ +H W++
Sbjct: 351 ISKLLVRDAKQRLSAAQVLQHPWVQ 375



>gi|46396051|sp|Q9Y2A5|DUET_HUMAN   Serine/threonine-protein kinase Duet (Serine/threonine kinase with
            Dbl- and pleckstrin homology domain)
          Length = 1289

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 54/199 (27%), Positives = 94/199 (47%), Gaps = 7/199 (3%)

Query: 16   TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
            T++ VA+K + K    +E       E  +++ L HP  I L+   E+     L+ E    
Sbjct: 1009 TRKDVAVKFVSKKMKKKEQAA---HEAALLQHLQHPQYITLHDTYESPTSYILILELMDD 1065

Query: 76   GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANL---NIKI 132
            G + D+L+ H  + E++     + I+ A+ + H   + H D+K ENLL+D  +    +K+
Sbjct: 1066 GRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKL 1125

Query: 133  ADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
             D   +   +    +    G+P +AAPE+ +G        DIWS+GV+ YV++ G  PF 
Sbjct: 1126 IDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPV-SLGTDIWSIGVLTYVMLSGVSPFL 1184

Query: 193  GSTLQNLRARVLSGKFRIP 211
              + +     V    F  P
Sbjct: 1185 DESKEETCINVCRVDFSFP 1203



>gi|1170598|sp|P45984|MK09_HUMAN   Mitogen-activated protein kinase 9 (Stress-activated protein kinase
           JNK2) (c-Jun N-terminal kinase 2) (JNK-55)
          Length = 424

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 64/274 (23%), Positives = 121/274 (44%), Gaps = 34/274 (12%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA 73
           VA+K + +   ++ + K+ +RE+ ++K + H +II L  V   ++       +YLV E  
Sbjct: 52  VAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 111

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
                    V H  +  +       Q++  +   H   I+HRDLK  N+++ ++  +KI 
Sbjct: 112 DANLC---QVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 168

Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           DFG +       ++  +  +  Y APE+  G  Y    VDIWS+G ++  LV G + F G
Sbjct: 169 DFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGELVKGCVIFQG 227

Query: 194 S----------------------TLQNLRARVLSGKFRIPFFMSTGLVPE--LDKRLKAG 229
           +                       LQ      +  + + P      L P+       +  
Sbjct: 228 TDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERD 287

Query: 230 CLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263
            +  ++   L+  MLV+DP+KR+S+++  +H ++
Sbjct: 288 KIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 321



>gi|14285497|sp|O14920|IKKB_HUMAN   Inhibitor of nuclear factor kappa B kinase beta subunit
           (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B)
           (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B
           inhibitor kinase beta) (NFKBIKB)
          Length = 756

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 61/198 (30%), Positives = 97/198 (48%), Gaps = 14/198 (7%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G +I+   QET + +AIK   + +L   N ++   E+QIM+ L HP+++    V E  + 
Sbjct: 27  GNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQN 85

Query: 66  I------YLVTEYASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRD 116
           +       L  EY  GG++  +L        + E         I +A+ + H   I+HRD
Sbjct: 86  LAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRD 145

Query: 117 LKAENLLL---DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173
           LK EN++L   +  L  KI D G++     G L  ++ G+  Y APEL E ++Y    VD
Sbjct: 146 LKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT-VTVD 204

Query: 174 IWSLGVVLYVLVCGALPF 191
            WS G + +  + G  PF
Sbjct: 205 YWSFGTLAFECITGFRPF 222



>gi|8488988|sp|Q13233|M3K1_HUMAN   Mitogen-activated protein kinase kinase kinase 1 (MAPK/ERK kinase
            kinase 1) (MEK kinase 1) (MEKK 1)
          Length = 1495

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 66/254 (25%), Positives = 112/254 (44%), Gaps = 22/254 (8%)

Query: 13   LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
            L   KQ+  ++     Q  EE ++ +  E+++M  L HP+IIR+      +    L  E+
Sbjct: 1251 LMAVKQVTYVRNTSSEQ--EEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEW 1308

Query: 73   ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA-NLNIK 131
             +GG +   L  +G   E       +Q++  + + H   I+HRD+K  NLL+D+    ++
Sbjct: 1309 MAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLR 1368

Query: 132  IADFGFSNLFT-----PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVC 186
            IADFG +          G+      G+  + APE+  G++Y G   D+WS+G  +  + C
Sbjct: 1369 IADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQY-GRSCDVWSVGCAIIEMAC 1427

Query: 187  GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246
               P++     N  A +    F+I    S    P +   L  G   +A         L L
Sbjct: 1428 AKPPWNAEKHSNHLALI----FKI---ASATTAPSIPSHLSPGLRDVA------LRCLEL 1474

Query: 247  DPNKRLSMEQICKH 260
             P  R    ++ KH
Sbjct: 1475 QPQDRPPSRELLKH 1488



>gi|125480|sp|P07948|LYN_HUMAN   Tyrosine-protein kinase Lyn
          Length = 512

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 56/183 (30%), Positives = 94/183 (51%), Gaps = 7/183 (3%)

Query: 34  NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH--GRMAEK 91
           +++    E  +MK L H  ++RLY V+  E  IY++TEY + G + D L +   G++   
Sbjct: 283 SVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP 342

Query: 92  EARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWC 151
           +      QI   + +   +N +HRDL+A N+L+  +L  KIADFG + +    +      
Sbjct: 343 KLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREG 402

Query: 152 GSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGSTLQNLRARVLSGKF 208
              P  + APE      +   K D+WS G++LY +V  G +P+ G T  ++    LS  +
Sbjct: 403 AKFPIKWTAPEAINFGCFT-IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMT-ALSQGY 460

Query: 209 RIP 211
           R+P
Sbjct: 461 RMP 463



>gi|12643358|sp|O94804|STK10_HUMAN   Serine/threonine-protein kinase 10 (Lymphocyte-oriented kinase)
          Length = 968

 Score = 86.3 bits (212), Expect = 7e-17
 Identities = 86/326 (26%), Positives = 146/326 (44%), Gaps = 37/326 (11%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           +ET  L A K+I+     EE L+    E++I+    HP+I++L      +  ++++ E+ 
Sbjct: 56  KETGALAAAKVIETKS--EEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFC 113

Query: 74  SGGEIFDHLVAHGR-MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
            GG +   ++   R + E + +   +Q++ A+ F H + I+HRDLKA N+L+    +I++
Sbjct: 114 PGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRL 173

Query: 133 ADFGFS--NLFTPGQLLKTWCGSPPYAAPEL-----FEGKEYDGPKVDIWSLGVVLYVLV 185
           ADFG S  NL T  Q   ++ G+P + APE+      +   YD  K DIWSLG+ L  + 
Sbjct: 174 ADFGVSAKNLKTL-QKRDSFIGTPYWMAPEVVMCETMKDTPYD-YKADIWSLGITLIEMA 231

Query: 186 CGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLV 245
               P     L  +R  +   K   P    T L P              E    ++  L 
Sbjct: 232 QIEPPH--HELNPMRVLLKIAKSDPP----TLLTPSKWS---------VEFRDFLKIALD 276

Query: 246 LDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLD 305
            +P  R S  Q+ +H ++    ++     L+AE +    E   D  +E           +
Sbjct: 277 KNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEG----------E 326

Query: 306 KEQTLQPDGTLNLDSDEGEEPSPEAL 331
           +E  +    TL   +    E SP +L
Sbjct: 327 EEDAVDAASTLENHTQNSSEVSPPSL 352



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 2/87 (2%)

Query: 1161 FSKLREQLGPVTQEFWDNLEKETEGLRQE-MSKDLEEVKAKVQPYLDDFQKKWQEEMELY 1219
            +++ +EQL  + +E  + +EK     R+E M + +EE   K Q    DF  K +E++EL 
Sbjct: 650  YTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELA 709

Query: 1220 RQKV-EPLRAELQEGARQKLHELQEKL 1245
             +++    R E+ +  R+ L + QE L
Sbjct: 710  MKRLTTDNRREICDKERECLMKKQELL 736



>gi|20178302|sp|Q07002|PCTK3_HUMAN   Serine/threonine-protein kinase PCTAIRE-3 (PCTAIRE-motif protein
           kinase 3)
          Length = 472

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 85/322 (26%), Positives = 146/322 (45%), Gaps = 43/322 (13%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           + LVA+K I + + +E       REV ++K L H +I+ L+ ++ T+R + LV EY    
Sbjct: 165 ENLVALKEI-RLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSD 223

Query: 77  --EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
             +  DH      M+    +    Q++  + +CH R I+HRDLK +NLL++    +K+AD
Sbjct: 224 LKQYLDH--CGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLAD 281

Query: 135 FGFSNL-FTPGQLLKTWCGSPPYAAPELFEGK-EYDGPKVDIWSLGVVLYVLVCGALPFD 192
           FG +     P +       +  Y  P++  G  EY  P +D+W +G + Y +  G   F 
Sbjct: 282 FGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTP-IDMWGVGCIHYEMATGRPLFP 340

Query: 193 GSTLQ---NLRARVLS-------------GKFR---IPFFMSTGLV---PELDKRLKAGC 230
           GST++   +L  R+L               +FR    P ++   L+   P LD       
Sbjct: 341 GSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLD------- 393

Query: 231 LSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK-LGDADPNFDRLIAECQQLKE-ERQV 288
               +  HL+  +L+ +   R+S E    H + + LG+     +   A    LKE + Q 
Sbjct: 394 ---TDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLED-TASIFSLKEIQLQK 449

Query: 289 DPLNEDVLLAMEDMGLDKEQTL 310
           DP    +       G ++ Q++
Sbjct: 450 DPGYRGLAFQQPGRGKNRRQSI 471



>gi|34222826|sp|Q86UE8|TLK2_HUMAN   Serine/threonine-protein kinase tousled-like 2 (Tousled-like kinase
           2) (PKU-alpha)
          Length = 772

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 83/256 (32%), Positives = 118/256 (46%), Gaps = 25/256 (9%)

Query: 17  KQLVAIKI--IDKTQLDE--ENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIYL-VT 70
           ++ VA+KI  ++K   DE  EN  K   RE +I K L HP I++LY     +   +  V 
Sbjct: 485 QRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVL 544

Query: 71  EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH--CRNIVHRDLKAENLLL---D 125
           EY  G ++  +L  H  M+EKEAR    QIV A+ + +     I+H DLK  N+LL    
Sbjct: 545 EYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGT 604

Query: 126 ANLNIKIADFGFSNLFTPG--------QLLKTWCGSPPYAAPELF-EGKEYD--GPKVDI 174
           A   IKI DFG S +            +L     G+  Y  PE F  GKE      KVD+
Sbjct: 605 ACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDV 664

Query: 175 WSLGVVLYVLVCGALPFDGSTLQN--LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLS 232
           WS+GV+ Y  + G  PF  +  Q   L+   +     + F     + PE  K     CL+
Sbjct: 665 WSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEA-KAFIRRCLA 723

Query: 233 IAECEHLIRHMLVLDP 248
             + + +    L  DP
Sbjct: 724 YRKEDRIDVQQLACDP 739



>gi|114006|sp|P06727|APOA4_HUMAN   Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV)
          Length = 396

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 53/229 (23%), Positives = 106/229 (46%), Gaps = 11/229 (4%)

Query: 1113 DRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVT 1172
            D+V  +   Y   L ++ ++ V   + S L +QLN    D    V +    L+++L P  
Sbjct: 25   DQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFA 84

Query: 1173 QEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQE 1232
             E  + L K++E L++E+ K+LEE++A++ P+ ++  +K  + +   +Q++EP   +L+ 
Sbjct: 85   TELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRT 144

Query: 1233 GARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDXXXXXXXXXXXXXXXNGGAR 1292
                +  +L+ +L+P  + M    R + D+L+  L P++D                    
Sbjct: 145  QVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKI-----------DQN 193

Query: 1293 LAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYT 1341
            + E   + T +      K    +E+LR+ L P  +  +      LE  T
Sbjct: 194  VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLT 242



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 44/199 (22%), Positives = 84/199 (42%), Gaps = 26/199 (13%)

Query: 1157 VTSTFSKLREQLGPVTQEF-----------WDNLEKETEGLRQEMSKDLEEVKAKVQPYL 1205
            V +   +LR QL P  Q               +L    + L+ ++ +++EE+K ++ PY 
Sbjct: 146  VNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYA 205

Query: 1206 DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRT 1265
            D+F+ K  + +E  R+ + P   + QE    +L  L  ++    EE++ R  A  + LR 
Sbjct: 206  DEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQ 265

Query: 1266 HLAPYSDXXXXXXXXXXXXXXXNGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPV 1325
             LAP ++                    L        + L+ L       +E+ R+ + P 
Sbjct: 266  RLAPLAEDVR---------------GNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPY 310

Query: 1326 LESFKVSFLSALEEYTKKL 1344
             E+F  + +  +E+  +KL
Sbjct: 311  GENFNKALVQQMEQLRQKL 329



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 33/148 (22%), Positives = 75/148 (50%), Gaps = 9/148 (6%)

Query: 1115 VKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQE 1174
            V++L        +D+      Q EG     + N + L     ++++  +LR++L P+ ++
Sbjct: 216  VEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKA--RISASAEELRQRLAPLAED 273

Query: 1175 FWDNLEKETEGLRQEMSK-------DLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLR 1227
               NL+  TEGL++ +++        +EE + +V+PY ++F K   ++ME  RQK+ P  
Sbjct: 274  VRGNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHA 333

Query: 1228 AELQEGARQKLHELQEKLSPLGEEMRDR 1255
             +++        +L++K++      +++
Sbjct: 334  GDVEGHLSFLEKDLRDKVNSFFSTFKEK 361



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query: 1157 VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEM 1216
            +  T  +LR  L P  Q+  + L  + EGL  +M K+ EE+KA++    ++ +++     
Sbjct: 212  IDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLA 271

Query: 1217 ELYR-------QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAP 1269
            E  R       + ++   AEL     Q++ E + ++ P GE         ++ LR  L P
Sbjct: 272  EDVRGNLKGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGP 331

Query: 1270 YS 1271
            ++
Sbjct: 332  HA 333



>gi|56749457|sp|Q15208|STK38_HUMAN   Serine/threonine-protein kinase 38 (NDR1 protein kinase) (Nuclear
           Dbf2-related kinase 1)
          Length = 465

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 61/237 (25%), Positives = 111/237 (46%), Gaps = 40/237 (16%)

Query: 14  QETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 72
           ++T  + A+KI+ K   L++E +  I  E  I+       +++++   + +  +YL+ E+
Sbjct: 109 KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEF 168

Query: 73  ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
             GG++   L+    + E+E +    + V A+   H    +HRD+K +NLLLD+  ++K+
Sbjct: 169 LPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKL 228

Query: 133 ADFG--------------------------FSNLFTPGQLLKTW-----------CGSPP 155
           +DFG                          F N+ +  +  +TW            G+P 
Sbjct: 229 SDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKA-ETWKRNRRQLAFSTVGTPD 287

Query: 156 YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 212
           Y APE+F    Y+    D WSLGV++Y ++ G  PF   T Q    +V++ K  + F
Sbjct: 288 YIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTF 343



>gi|462203|sp|P34947|GRK5_HUMAN   G protein-coupled receptor kinase 5 (G protein-coupled receptor
           kinase GRK5)
          Length = 590

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 54/184 (29%), Positives = 95/184 (51%), Gaps = 4/184 (2%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71
           ++ T ++ A K ++K ++ +   + +   E QI++ +    ++ L    ET+  + LV  
Sbjct: 205 VRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLT 264

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
             +GG++  H+   G    +E R  F   +I+  +   H  N V+RDLK EN+LLD   +
Sbjct: 265 IMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGH 324

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           I+I+D G +     G L++   G+  Y APE+   + Y G   D W LG ++Y ++ G  
Sbjct: 325 IRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQS 383

Query: 190 PFDG 193
           PF G
Sbjct: 384 PFRG 387



>gi|1706450|sp|Q09013|DMPK_HUMAN   Myotonin-protein kinase (Myotonic dystrophy protein kinase) (MDPK)
           (DM-kinase) (DMK) (DMPK) (MT-PK)
          Length = 639

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 63/219 (28%), Positives = 107/219 (48%), Gaps = 10/219 (4%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKIFREVQ-IMKMLCHPHIIRLYQVMETERMIYLVTE 71
           +++T Q+ A+KI++K  + +      FRE + ++       I +L+   + E  +YLV E
Sbjct: 100 MKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME 159

Query: 72  YASGGEIFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130
           Y  GG++   L   G R+  + AR    +IV A+   H    VHRD+K +N+LLD   +I
Sbjct: 160 YYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHI 219

Query: 131 KIADFGFSNLFTPGQLLKTW--CGSPPYAAPELFE------GKEYDGPKVDIWSLGVVLY 182
           ++ADFG          +++    G+P Y +PE+ +      G    GP+ D W+LGV  Y
Sbjct: 220 RLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAY 279

Query: 183 VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPE 221
            +  G  PF   +      +++  K  +   +    VPE
Sbjct: 280 EMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPE 318



>gi|14285498|sp|O15111|IKKA_HUMAN   Inhibitor of nuclear factor kappa-B kinase alpha subunit (I kappa-B
           kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB
           kinase) (I-kappa-B kinase 1) (IKK1) (Conserved
           helix-loop-helix ubiquitous kinase) (Nuclear factor
           NFkappaB inhibitor kinase alpha) (NFKBIKA)
          Length = 745

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 57/183 (31%), Positives = 90/183 (49%), Gaps = 13/183 (7%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIY-----LVTEYAS 74
           +AIK   + +L  +N ++   E+QIMK L H ++++   V E   ++      L  EY S
Sbjct: 41  IAIKSC-RLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCS 99

Query: 75  GGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD---ANL 128
           GG++   L        + E +       I + + + H   I+HRDLK EN++L      +
Sbjct: 100 GGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKI 159

Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188
             KI D G++     G L  ++ G+  Y APELFE K Y    VD WS G +++  + G 
Sbjct: 160 IHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTA-TVDYWSFGTMVFECIAGY 218

Query: 189 LPF 191
            PF
Sbjct: 219 RPF 221



>gi|59803097|sp|Q00537|PCTK2_HUMAN   Serine/threonine-protein kinase PCTAIRE-2 (PCTAIRE-motif protein
           kinase 2)
          Length = 523

 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 70/273 (25%), Positives = 126/273 (46%), Gaps = 36/273 (13%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T+ LVA+K I + + +E       REV ++K L H +I+ L+ ++ T++ + LV EY   
Sbjct: 214 TENLVALKEI-RLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDK 272

Query: 76  GEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
            ++  ++   G +      + F  QI+  + +CH R ++HRDLK +NLL++    +K+AD
Sbjct: 273 -DLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLAD 331

Query: 135 FGFSNL-FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           FG +     P +       +  Y  P++  G      ++D+W +G + + +  G   F G
Sbjct: 332 FGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPG 391

Query: 194 STLQ---NLRARVLS----------------GKFRIPFFMSTGLV---PELDKRLKAGCL 231
           ST++   +L  R+L                   +  P +    L+   P LD        
Sbjct: 392 STVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLD-------- 443

Query: 232 SIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
             +E   LI   L  +  KR+S E+  KH + +
Sbjct: 444 --SEGIELITKFLQYESKKRVSAEEAMKHVYFR 474



>gi|20141386|sp|P43250|GRK6_HUMAN   G protein-coupled receptor kinase 6 (G protein-coupled receptor
           kinase GRK6)
          Length = 576

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 55/182 (30%), Positives = 96/182 (52%), Gaps = 4/182 (2%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71
           ++ T ++ A K ++K ++ +   + +   E QI++ +    ++ L    ET+  + LV  
Sbjct: 205 VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT 264

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
             +GG++  H+   G+    EAR  F   +I   +   H   IV+RDLK EN+LLD + +
Sbjct: 265 LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH 324

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           I+I+D G +     GQ +K   G+  Y APE+ + + Y     D W+LG +LY ++ G  
Sbjct: 325 IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWWALGCLLYEMIAGQS 383

Query: 190 PF 191
           PF
Sbjct: 384 PF 385



>gi|125351|sp|P16591|FER_HUMAN   Proto-oncogene tyrosine-protein kinase FER (p94-FER) (c-FER)
          Length = 822

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 18/200 (9%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           K  VA+K   K  L +E   K  +E +I+K   HP+I++L  V    + +Y++ E  SGG
Sbjct: 585 KTSVAVKTC-KEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGG 643

Query: 77  EIFDHLVAHGRMAEKEARRKFKQIV-------TAVYFCHCRNIVHRDLKAENLLLDANLN 129
           +    L        K+   K KQ+V         + +   +N +HRDL A N L+  N  
Sbjct: 644 DFLTFL------RRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNV 697

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVC 186
           +KI+DFG S     G    +     P  + APE      Y   + D+WS G++L+     
Sbjct: 698 LKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSS-ESDVWSFGILLWETFSL 756

Query: 187 GALPFDGSTLQNLRARVLSG 206
           G  P+ G T Q  R +V  G
Sbjct: 757 GVCPYPGMTNQQAREQVERG 776



>gi|1169745|sp|P42685|FRK_HUMAN   Tyrosine-protein kinase FRK (Nuclear tyrosine protein kinase RAK)
          Length = 505

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 59/206 (28%), Positives = 100/206 (48%), Gaps = 25/206 (12%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K +    +D  +     RE QIMK L HP +I+LY V   E  IY++TE    G + 
Sbjct: 259 VAVKTLKPGSMDPNDF---LREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQ 315

Query: 80  DHLV--AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           ++L      ++   +      Q+ + + +   RN +HRDL A N+L+  +   K+ADFG 
Sbjct: 316 EYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGL 375

Query: 138 SNLFTPG-----------QLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLV 185
           + +F              +L   W       APE     ++   K D+WS G++LY ++ 
Sbjct: 376 ARVFKVDNEDIYESRHEIKLPVKW------TAPEAIRSNKF-SIKSDVWSFGILLYEIIT 428

Query: 186 CGALPFDGSTLQNLRARVLSGKFRIP 211
            G +P+ G T   +  ++L+  +R+P
Sbjct: 429 YGKMPYSGMTGAQV-IQMLAQNYRLP 453



>gi|266425|sp|Q00536|PCTK1_HUMAN   Serine/threonine-protein kinase PCTAIRE-1 (PCTAIRE-motif protein
           kinase 1)
          Length = 496

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 53/184 (28%), Positives = 97/184 (52%), Gaps = 4/184 (2%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T  LVA+K I + + +E       REV ++K L H +I+ L+ ++ TE+ + LV EY   
Sbjct: 187 TDNLVALKEI-RLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDK 245

Query: 76  GEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
            ++  +L   G +      + F  Q++  + +CH + ++HRDLK +NLL++    +K+AD
Sbjct: 246 -DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLAD 304

Query: 135 FGFSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           FG +   + P +       +  Y  P++  G      ++D+W +G + Y +  G   F G
Sbjct: 305 FGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG 364

Query: 194 STLQ 197
           ST++
Sbjct: 365 STVE 368



>gi|125474|sp|P06239|LCK_HUMAN   Proto-oncogene tyrosine-protein kinase LCK (P56-LCK) (LSK) (T
           cell-specific protein-tyrosine kinase)
          Length = 509

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 59/189 (31%), Positives = 92/189 (48%), Gaps = 14/189 (7%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K + +  +  +       E  +MK L H  ++RLY V+ T+  IY++TEY   G + 
Sbjct: 270 VAVKSLKQGSMSPD---AFLAEANLMKQLQHQRLVRLYAVV-TQEPIYIITEYMENGSLV 325

Query: 80  DHLVAHG--RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           D L      ++   +      QI   + F   RN +HRDL+A N+L+   L+ KIADFG 
Sbjct: 326 DFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGL 385

Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS 194
           + L    +         P  + APE      +   K D+WS G++L  +V  G +P+ G 
Sbjct: 386 ARLIEDNEYTAREGAKFPIKWTAPEAINYGTFT-IKSDVWSFGILLTEIVTHGRIPYPGM 444

Query: 195 T----LQNL 199
           T    +QNL
Sbjct: 445 TNPEVIQNL 453



>gi|34223086|sp|Q9UKI8|TLK1_HUMAN   Serine/threonine-protein kinase tousled-like 1 (Tousled-like kinase
           1) (PKU-beta)
          Length = 766

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 81/259 (31%), Positives = 116/259 (44%), Gaps = 22/259 (8%)

Query: 11  DFLQETKQLVAIKIIDKTQLDE--ENLKK-IFREVQIMKMLCHPHIIRLYQVMETERMIY 67
           D  ++    V I  ++K+  DE  EN  K   RE +I K L HP I++LY     +   +
Sbjct: 475 DLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTF 534

Query: 68  L-VTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCH--CRNIVHRDLKAENLLL 124
             V EY  G ++  +L  H  M+EKEAR    QIV A+ + +     I+H DLK  N+LL
Sbjct: 535 CTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILL 594

Query: 125 ---DANLNIKIADFGFSNLFTPG-------QLLKTWCGSPPYAAPELF-EGKEYD--GPK 171
               A   IKI DFG S +            L     G+  Y  PE F  GKE      K
Sbjct: 595 VDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNK 654

Query: 172 VDIWSLGVVLYVLVCGALPFDGSTLQN--LRARVLSGKFRIPFFMSTGLVPELDKRLKAG 229
           VD+WS+GV+ +  + G  PF  +  Q   L+   +     + F +   +V    K     
Sbjct: 655 VDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKP-VVSSEAKAFIRR 713

Query: 230 CLSIAECEHLIRHMLVLDP 248
           CL+  + +    H L  DP
Sbjct: 714 CLAYRKEDRFDVHQLANDP 732



>gi|464971|sp|P33981|TTK_HUMAN   Dual specificity protein kinase TTK (Phosphotyrosine picked
           threonine kinase) (PYT)
          Length = 841

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 69/270 (25%), Positives = 121/270 (44%), Gaps = 36/270 (13%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH--PHIIRLYQVMETERMIYLVT 70
           L E KQ+ AIK ++  + D + L     E+  +  L      IIRLY    T++ IY+V 
Sbjct: 527 LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVM 586

Query: 71  EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130
           E     ++   L     +   E +  +K ++ AV+  H   IVH DLK  N L+   + +
Sbjct: 587 E-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-L 644

Query: 131 KIADFGFSNLFTPGQ---LLKTWCGSPPYAAPELFE----------GKEYDGPKVDIWSL 177
           K+ DFG +N   P     +  +  G+  Y  PE  +           K    PK D+WSL
Sbjct: 645 KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL 704

Query: 178 GVVLYVLVCGALPFDG--STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAE 235
           G +LY +  G  PF    + +  L A ++     I F       P++ ++         +
Sbjct: 705 GCILYYMTYGKTPFQQIINQISKLHA-IIDPNHEIEF-------PDIPEK---------D 747

Query: 236 CEHLIRHMLVLDPNKRLSMEQICKHKWMKL 265
            + +++  L  DP +R+S+ ++  H ++++
Sbjct: 748 LQDVLKCCLKRDPKQRISIPELLAHPYVQI 777



>gi|19857975|sp|P29322|EPHA8_HUMAN   Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase
           receptor EEK) (EPH-and ELK-related kinase) (HEK3)
          Length = 1005

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 63/198 (31%), Positives = 95/198 (47%), Gaps = 9/198 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + K    E   +    E  IM    HP+IIRL  V+   R+  +VTEY   G + 
Sbjct: 664 VAIKAL-KAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLD 722

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L  H G+    +     + +   + +      VHRDL A N+L+D+NL  K++DFG S
Sbjct: 723 TFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLS 782

Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193
            +    P     T  G  P  + APE    + +     D+WS GVV++ VL  G  P+  
Sbjct: 783 RVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSAS-DVWSFGVVMWEVLAYGERPYWN 841

Query: 194 STLQNLRARVLSGKFRIP 211
            T +++ + V  G +R+P
Sbjct: 842 MTNRDVISSVEEG-YRLP 858



>gi|8928302|sp|Q13882|PTK6_HUMAN   Tyrosine-protein kinase 6 (Breast tumor kinase) (Tyrosine-protein
           kinase brk)
          Length = 451

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 62/212 (29%), Positives = 101/212 (47%), Gaps = 10/212 (4%)

Query: 6   GYIIQDF--LQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE 63
           GY  + F  L + +  VAIK+I +  L  + + +   E+Q MK L H HI+ LY V+   
Sbjct: 200 GYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQ--SEIQAMKKLRHKHILALYAVVSVG 257

Query: 64  RMIYLVTEYASGGEIFDHLVAHGR--MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121
             +Y++TE  + G + + L       +   E      Q+   + +   +N +HRDL A N
Sbjct: 258 DPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARN 317

Query: 122 LLLDANLNIKIADFGFSNLFTPGQLLKTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVV 180
           +L+  N   K+ DFG + L      L      P  + APE      Y   K D+WS G++
Sbjct: 318 ILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHY-STKSDVWSFGIL 376

Query: 181 LYVLVC-GALPFDGSTLQNLRARVLSGKFRIP 211
           L+ +   G +P+ G +      RV +G +R+P
Sbjct: 377 LHEMFSRGQVPYPGMSNHEAFLRVDAG-YRMP 407



>gi|41688789|sp|Q96J92|WNK4_HUMAN   Serine/threonine-protein kinase WNK4 (Protein kinase with no lysine
           4) (Protein kinase, lysine-deficient 4)
          Length = 1243

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 65/243 (26%), Positives = 119/243 (48%), Gaps = 25/243 (10%)

Query: 29  QLDEENLKKIFREVQIMKMLCHPHIIRLYQ----VMETERMIYLVTEYASGGEIFDHLVA 84
           +L     ++   EV+++K L HP+I+R Y     V+  +  I LVTE  + G +  +L  
Sbjct: 209 KLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRR 268

Query: 85  HGRMAEKEARRKFKQIVTAVYFCHCR--NIVHRDLKAENLLLDANL-NIKIADFGFSNLF 141
              M  +  +R  +QI+  ++F H R   I+HRDLK +N+ +     ++KI D G + L 
Sbjct: 269 FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL- 327

Query: 142 TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRA 201
                 K+  G+P + APE++E K YD   VD+++ G+ +  +     P+  S  QN   
Sbjct: 328 KRASFAKSVIGTPEFMAPEMYEEK-YD-EAVDVYAFGMCMLEMATSEYPY--SECQNAA- 382

Query: 202 RVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHK 261
                  +I   +++G  P    ++K     I E + +I   +  D N+R +++ +  H 
Sbjct: 383 -------QIYRKVTSGRKPNSFHKVK-----IPEVKEIIEGCIRTDKNERFTIQDLLAHA 430

Query: 262 WMK 264
           + +
Sbjct: 431 FFR 433



>gi|125135|sp|P00519|ABL1_HUMAN   Proto-oncogene tyrosine-protein kinase ABL1 (p150) (c-ABL)
          Length = 1130

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 56/200 (28%), Positives = 97/200 (48%), Gaps = 11/200 (5%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G + +   ++    VA+K + +  ++ E   K   E  +MK + HP++++L  V   E  
Sbjct: 254 GEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK---EAAVMKEIKHPNLVQLLGVCTREPP 310

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK--QIVTAVYFCHCRNIVHRDLKAENLL 123
            Y++TE+ + G + D+L    R         +   QI +A+ +   +N +HRDL A N L
Sbjct: 311 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 370

Query: 124 LDANLNIKIADFGFSNLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVV 180
           +  N  +K+ADFG S L T G       G+     + APE     ++   K D+W+ GV+
Sbjct: 371 VGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKF-SIKSDVWAFGVL 428

Query: 181 LY-VLVCGALPFDGSTLQNL 199
           L+ +   G  P+ G  L  +
Sbjct: 429 LWEIATYGMSPYPGIDLSQV 448



>gi|1351326|sp|P42681|TXK_HUMAN   Tyrosine-protein kinase TXK
          Length = 527

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 56/196 (28%), Positives = 103/196 (52%), Gaps = 11/196 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK I++  + EE+      E ++M  L H  +++LY V    + +Y+VTE+   G + 
Sbjct: 296 VAIKAINEGSMSEEDF---IEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLL 352

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
           ++L  + G++ ++      + I   + +      +HRDL A N L+ +   +KI+DFG +
Sbjct: 353 NYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMT 412

Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG-S 194
                 + + ++    P  ++ PE+F   +Y   K D+WS GV+++ V   G +PF+  S
Sbjct: 413 RYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSS-KSDVWSFGVLMWEVFTEGKMPFENKS 471

Query: 195 TLQNLRARVLSGKFRI 210
            LQ + A  +S  FR+
Sbjct: 472 NLQVVEA--ISEGFRL 485



>gi|2507195|sp|P45983|MK08_HUMAN   Mitogen-activated protein kinase 8 (Stress-activated protein kinase
           JNK1) (c-Jun N-terminal kinase 1) (JNK-46)
          Length = 427

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 69/279 (24%), Positives = 128/279 (45%), Gaps = 40/279 (14%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA 73
           VAIK + +   ++ + K+ +RE+ +MK + H +II L  V   ++       +Y+V E  
Sbjct: 52  VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELM 111

Query: 74  SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
                ++    + H RM+         Q++  +   H   I+HRDLK  N+++ ++  +K
Sbjct: 112 DANLCQVIQMELDHERMSYL-----LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 166

Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           I DFG +       ++  +  +  Y APE+  G  Y    VD+WS+G ++  +VC  + F
Sbjct: 167 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK-ENVDLWSVGCIMGEMVCHKILF 225

Query: 192 DGSTLQNLRARVLSG-KFRIPFFMSTGLVPELD--------------KRLKAGCLSIAEC 236
            G    +   +V+       P FM   L P +               ++L    L  A+ 
Sbjct: 226 PGRDYIDQWNKVIEQLGTPCPEFMKK-LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADS 284

Query: 237 EH----------LIRHMLVLDPNKRLSMEQICKHKWMKL 265
           EH          L+  MLV+D +KR+S+++  +H ++ +
Sbjct: 285 EHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINV 323



>gi|29427817|sp|Q8IVH8|M4K3_HUMAN   Mitogen-activated protein kinase kinase kinase kinase 3 (MAPK/ERK
           kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
           (Germinal center kinase related protein kinase) (GLK)
          Length = 894

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 67/252 (26%), Positives = 119/252 (47%), Gaps = 20/252 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T +L AIK+I       E+   + +E+ +MK   HP+I+  +        +++  E+  G
Sbjct: 38  TGELAAIKVIKLEP--GEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGG 95

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           G + D     G ++E +     ++ +  +Y+ H +  +HRD+K  N+LL  N ++K+ADF
Sbjct: 96  GSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADF 155

Query: 136 GFSNLFTPG-QLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALP-F 191
           G S   T      K++ G+P + APE+   E K       D+W++G+    L     P F
Sbjct: 156 GVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMF 215

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
           D   L  +RA  L  K       S    P+L  ++K          H ++  L  +P KR
Sbjct: 216 D---LHPMRALFLMTK-------SNFQPPKLKDKMKWS----NSFHHFVKMALTKNPKKR 261

Query: 252 LSMEQICKHKWM 263
            + E++ +H ++
Sbjct: 262 PTAEKLLQHPFV 273



>gi|1730068|sp|P10398|ARAF_HUMAN   A-Raf proto-oncogene serine/threonine-protein kinase (A-raf-1)
           (Proto-oncogene Pks)
          Length = 606

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 51/178 (28%), Positives = 95/178 (53%), Gaps = 7/178 (3%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K++  +Q   E  +    E+Q+++   H +I+ L+    T     ++T++  G  ++
Sbjct: 333 VAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNIL-LFMGFMTRPGFAIITQWCEGSSLY 391

Query: 80  DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
            HL VA  R    +     +Q    + + H +NI+HRDLK+ N+ L   L +KI DFG +
Sbjct: 392 HHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLA 451

Query: 139 NL---FTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPF 191
            +   ++  Q L+   GS  + A E+   ++ +    + D+++ GVVLY L+ G+LP+
Sbjct: 452 TVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPY 509



>gi|2507196|sp|P53779|MK10_HUMAN   Mitogen-activated protein kinase 10 (Stress-activated protein
           kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49
           3F12)
          Length = 464

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 68/281 (24%), Positives = 122/281 (43%), Gaps = 44/281 (15%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM------IYLVTEYA 73
           VAIK + +   ++ + K+ +RE+ +MK + H +II L  V   ++       +YLV E  
Sbjct: 90  VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149

Query: 74  SGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
                ++    + H RM+         Q++  +   H   I+HRDLK  N+++ ++  +K
Sbjct: 150 DANLCQVIQMELDHERMSYL-----LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204

Query: 132 IADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           I DFG +       ++  +  +  Y APE+  G  Y    VDIWS+G ++  +V   + F
Sbjct: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILF 263

Query: 192 DG--------------------------STLQN-LRARVLSGKFRIPFFMSTGLVPELDK 224
            G                           T++N +  R        P      L P   +
Sbjct: 264 PGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSE 323

Query: 225 RLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 265
             K   L  ++   L+  MLV+DP KR+S++   +H ++ +
Sbjct: 324 HNK---LKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361



>gi|1168268|sp|P42684|ABL2_HUMAN   Tyrosine-protein kinase ABL2 (Tyrosine kinase ARG)
          Length = 1182

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 57/186 (30%), Positives = 90/186 (48%), Gaps = 11/186 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K + +  ++ E   K   E  +MK + HP++++L  V   E   Y+VTEY   G + 
Sbjct: 314 VAVKTLKEDTMEVEEFLK---EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLL 370

Query: 80  DHLVAHGRMAEKEARRKFK--QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           D+L    R         +   QI +A+ +   +N +HRDL A N L+  N  +K+ADFG 
Sbjct: 371 DYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGL 430

Query: 138 SNLFTPGQLLKTWCGSP---PYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193
           S L T G       G+     + APE      +   K D+W+ GV+L+ +   G  P+ G
Sbjct: 431 SRLMT-GDTYTAHAGAKFPIKWTAPESLAYNTF-SIKSDVWAFGVLLWEIATYGMSPYPG 488

Query: 194 STLQNL 199
             L  +
Sbjct: 489 IDLSQV 494



>gi|41688795|sp|Q9H4A3|WNK1_HUMAN   Serine/threonine-protein kinase WNK1 (Protein kinase with no lysine
           1) (Protein kinase, lysine-deficient 1) (Kinase
           deficient protein)
          Length = 2382

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 68/227 (29%), Positives = 111/227 (48%), Gaps = 18/227 (7%)

Query: 15  ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET----ERMIYLVT 70
           ET   VA   +   +L +   ++   E +++K L HP+I+R Y   E+    ++ I LVT
Sbjct: 242 ETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVT 301

Query: 71  EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL 128
           E  + G +  +L     M  K  R   +QI+  + F H R   I+HRDLK +N+ +    
Sbjct: 302 ELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPT 361

Query: 129 -NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187
            ++KI D G + L       K+  G+P + APE++E K YD   VD+++ G+ +  +   
Sbjct: 362 GSVKIGDLGLATL-KRASFAKSVIGTPEFMAPEMYEEK-YD-ESVDVYAFGMCMLEMATS 418

Query: 188 ALPFDGSTLQN---LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCL 231
             P+  S  QN   +  RV SG    P       +PE+ K +  GC+
Sbjct: 419 EYPY--SECQNAAQIYRRVTSGV--KPASFDKVAIPEV-KEIIEGCI 460



>gi|27805732|sp|Q9H3Y6|SRMS_HUMAN   Tyrosine-protein kinase Srms
          Length = 488

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 61/197 (30%), Positives = 94/197 (47%), Gaps = 10/197 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK+I    +   +L K   E+Q +K L H  +IRL+ V      +Y+VTE    G + 
Sbjct: 255 VAIKVIKSANMKLTDLAK---EIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQ 311

Query: 80  DHL-VAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
             L    GR         F  Q+   + +   + +VHRDL A N+L+D  L  K+ADFG 
Sbjct: 312 AFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGL 371

Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS 194
           + L        +     P  + APE    + +   K D+WS GV+L+ V   G  P++G 
Sbjct: 372 ARLLKDDIYSPSSSSKIPVKWTAPEAANYRVF-SQKSDVWSFGVLLHEVFTYGQCPYEGM 430

Query: 195 TLQNLRARVLSGKFRIP 211
           T      +++ G +R+P
Sbjct: 431 TNHETLQQIMRG-YRLP 446



>gi|125651|sp|P04049|RAF1_HUMAN   RAF proto-oncogene serine/threonine-protein kinase (Raf-1) (C-RAF)
           (cRaf)
          Length = 648

 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 65/257 (25%), Positives = 124/257 (48%), Gaps = 23/257 (8%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+KI+       E  +    EV +++   H +I+ L+    T+  + +VT++  G  ++
Sbjct: 372 VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLY 430

Query: 80  DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
            HL V   +    +     +Q    + + H +NI+HRD+K+ N+ L   L +KI DFG +
Sbjct: 431 KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA 490

Query: 139 NL---FTPGQLLKTWCGSPPYAAPELFEGKEYD--GPKVDIWSLGVVLYVLVCGALPFDG 193
            +   ++  Q ++   GS  + APE+   ++ +    + D++S G+VLY L+ G LP+  
Sbjct: 491 TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSH 550

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLV-PELDKRL----KAGCLSIAECEHLIRHMLVLDP 248
                     ++ + +I F +  G   P+L K      KA    +A+C   ++    L P
Sbjct: 551 ----------INNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP 600

Query: 249 NKRLSMEQICKHKWMKL 265
            + LS  ++ +H   K+
Sbjct: 601 -QILSSIELLQHSLPKI 616



>gi|50403720|sp|P15056|BRAF1_HUMAN   B-Raf proto-oncogene serine/threonine-protein kinase (p94) (v-Raf
           murine sarcoma viral oncogene homolog B1)
          Length = 766

 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 63/252 (25%), Positives = 123/252 (48%), Gaps = 24/252 (9%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VA+K+++ T    + L+    EV +++   H +I+ L+    T+  + +VT++  G  ++
Sbjct: 480 VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLY 538

Query: 80  DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
            HL +   +    +     +Q    + + H ++I+HRDLK+ N+ L  +L +KI DFG +
Sbjct: 539 HHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLA 598

Query: 139 NL---FTPGQLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
            +   ++     +   GS  + APE+   + K     + D+++ G+VLY L+ G LP+  
Sbjct: 599 TVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN 658

Query: 194 STLQNLRARVLSGKFRIPFFMSTG-LVPELDKRLKAGCLS-----IAECEHLIRHMLVLD 247
                     ++ + +I F +  G L P+L K +++ C       +AEC    R    L 
Sbjct: 659 ----------INNRDQIIFMVGRGYLSPDLSK-VRSNCPKAMKRLMAECLKKKRDERPLF 707

Query: 248 PNKRLSMEQICK 259
           P    S+E + +
Sbjct: 708 PQILASIELLAR 719



>gi|12643557|sp|O43318|M3K7_HUMAN   Mitogen-activated protein kinase kinase kinase 7 (Transforming
           growth factor-beta-activated kinase 1)
           (TGF-beta-activated kinase 1)
          Length = 606

 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 80/251 (31%), Positives = 119/251 (47%), Gaps = 39/251 (15%)

Query: 20  VAIKIIDKTQLDEENLKKIFR-EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI 78
           VAIK     Q++ E+ +K F  E++ +  + HP+I++LY        + LV EYA GG +
Sbjct: 60  VAIK-----QIESESERKAFIVELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSL 112

Query: 79  FDHLVAHGR-----MAEKEARRKFKQIVTAVYFCHC---RNIVHRDLKAENLLLDANLNI 130
           ++  V HG           A     Q    V + H    + ++HRDLK  NLLL A   +
Sbjct: 113 YN--VLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTV 170

Query: 131 -KIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGA 188
            KI DFG + ++ T     K   GS  + APE+FEG  Y   K D++S G++L+ ++   
Sbjct: 171 LKICDFGTACDIQTHMTNNK---GSAAWMAPEVFEGSNY-SEKCDVFSWGIILWEVITRR 226

Query: 189 LPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDP 248
            PFD          +    FRI + +  G  P L K L          E L+      DP
Sbjct: 227 KPFD---------EIGGPAFRIMWAVHNGTRPPLIKNLP------KPIESLMTRCWSKDP 271

Query: 249 NKRLSMEQICK 259
           ++R SME+I K
Sbjct: 272 SQRPSMEEIVK 282



>gi|41688792|sp|Q9BYP7|WNK3_HUMAN   Serine/threonine-protein kinase WNK3 (Protein kinase with no lysine
           3) (Protein kinase, lysine-deficient 3)
          Length = 1743

 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 67/228 (29%), Positives = 115/228 (50%), Gaps = 22/228 (9%)

Query: 28  TQLDEENLKKIFREVQIMKMLCHPHIIRLY----QVMETERMIYLVTEYASGGEIFDHLV 83
           T+ +++  K+   E +++K L HP+I+R Y     +++ ++ I LVTE  + G +  +L 
Sbjct: 184 TKAEQQRFKE---EAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 240

Query: 84  AHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL-NIKIADFGFSNL 140
               M  K  R   +QI+  + F H R   I+HRDLK +N+ +     ++KI D G + L
Sbjct: 241 RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 300

Query: 141 FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQN-- 198
                  K+  G+P + APE++E  E+    VD+++ G+ +  +     P+  S  QN  
Sbjct: 301 MRT-SFAKSVIGTPEFMAPEMYE--EHYDESVDVYAFGMCMLEMATSEYPY--SECQNAA 355

Query: 199 -LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHL-IRHML 244
            +  +V SG     F   T   PE+ K +  GC+   + E L IR +L
Sbjct: 356 QIYRKVTSGIKPASFNKVTD--PEV-KEIIEGCIRQNKSERLSIRDLL 400



>gi|50400798|sp|Q9UBE8|NLK_HUMAN   Serine/threonine kinase NLK (Nemo-like kinase) (LAK1 protein)
          Length = 515

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 62/270 (22%), Positives = 118/270 (43%), Gaps = 26/270 (9%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-----IYLVTEYAS 74
           VA+K +     +  + K++FRE++++    H +++    +++   +     IY+VTE   
Sbjct: 152 VALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQ 211

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
             ++   +V+   ++    +    QI+  + + H   I+HRD+K  NLL+++N  +KI D
Sbjct: 212 S-DLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICD 270

Query: 135 FGFSNL--FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFD 192
           FG + +      + +     +  Y APE+  G  +    +DIWS+G +   L+   + F 
Sbjct: 271 FGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQ 330

Query: 193 GS----------------TLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAEC 236
                             +L+ +R      K  I         P L         +  E 
Sbjct: 331 AQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHI--LRGPHKQPSLPVLYTLSSQATHEA 388

Query: 237 EHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266
            HL+  MLV DP+KR+S +    H ++  G
Sbjct: 389 VHLLCRMLVFDPSKRISAKDALAHPYLDEG 418



>gi|2851522|sp|P53778|MK12_HUMAN   Mitogen-activated protein kinase 12 (Extracellular signal-regulated
           kinase 6) (ERK-6) (ERK5) (Stress-activated protein
           kinase-3) (Mitogen-activated protein kinase p38 gamma)
           (MAP kinase p38 gamma)
          Length = 367

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 68/267 (25%), Positives = 120/267 (44%), Gaps = 29/267 (10%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMI------YLVTEYA 73
           VAIK + +    E   K+ +RE++++K + H ++I L  V   +  +      YLV  + 
Sbjct: 53  VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM 112

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
             G     L+ H ++ E   +    Q++  + + H   I+HRDLK  NL ++ +  +KI 
Sbjct: 113 --GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKIL 170

Query: 134 DFGF---SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           DFG    ++    G ++  W     Y APE+          VDIWS+G ++  ++ G   
Sbjct: 171 DFGLARQADSEMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL 225

Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGL-----------VPELDKRLKAGCLSIAE--CE 237
           F GS   +    ++      P      L           +PEL+K+  A  L+ A     
Sbjct: 226 FKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAV 285

Query: 238 HLIRHMLVLDPNKRLSMEQICKHKWMK 264
           +L+  MLVLD  +R++  +   H + +
Sbjct: 286 NLLEKMLVLDAEQRVTAGEALAHPYFE 312



>gi|12644292|sp|P49840|GSK3A_HUMAN   Glycogen synthase kinase-3 alpha (GSK-3 alpha)
          Length = 483

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 85/315 (26%), Positives = 133/315 (42%), Gaps = 52/315 (16%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRL----YQVME 61
           G + Q  L ET++LVAIK +    L ++  K   RE+QIM+ L H +I+RL    Y   E
Sbjct: 131 GVVYQARLAETRELVAIKKV----LQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGE 184

Query: 62  TERMIYL--VTEYASGGEIFDHLVAHGRMAEKE-----ARRKFKQIVTAVYFCHCRNIVH 114
            +  +YL  V EY    E    +  H   A+        +    Q+  ++ + H + + H
Sbjct: 185 KKDELYLNLVLEYVP--ETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCH 242

Query: 115 RDLKAENLLLDANLNI-KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173
           RD+K +NLL+D +  + K+ DFG +     G+   ++  S  Y APEL  G       +D
Sbjct: 243 RDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 302

Query: 174 IWSLGVVLYVLVCGALPFDGSTLQNLRARVLS-----------------GKFRIPFFMST 216
           +WS G VL  L+ G   F G +  +    ++                   +F+ P   + 
Sbjct: 303 VWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH 362

Query: 217 GLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLI 276
                   R      +IA C  L+ +     P+ RLS  + C H +         FD L 
Sbjct: 363 PWTKVFKSRTPPE--AIALCSSLLEY----TPSSRLSPLEACAHSF---------FDELR 407

Query: 277 AECQQLKEERQVDPL 291
               QL   R + PL
Sbjct: 408 CLGTQLPNNRPLPPL 422



>gi|125711|sp|P12931|SRC_HUMAN   Proto-oncogene tyrosine-protein kinase Src (p60-Src) (c-Src)
          Length = 536

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 63/197 (31%), Positives = 97/197 (49%), Gaps = 11/197 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK +    +  E      +E Q+MK L H  +++LY V+ +E  IY+VTEY S G + 
Sbjct: 295 VAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLL 350

Query: 80  DHLVAH-GRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           D L    G+     +      QI + + +    N VHRDL+A N+L+  NL  K+ADFG 
Sbjct: 351 DFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGL 410

Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS 194
           + L    +         P  + APE      +   K D+WS G++L  L   G +P+ G 
Sbjct: 411 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILLTELTTKGRVPYPGM 469

Query: 195 TLQNLRARVLSGKFRIP 211
             + +  +V  G +R+P
Sbjct: 470 VNREVLDQVERG-YRMP 485



>gi|37537965|sp|Q8TDX7|NEK7_HUMAN   Serine/threonine-protein kinase Nek7 (NimA-related protein kinase
           7)
          Length = 302

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 47/173 (27%), Positives = 85/173 (49%), Gaps = 8/173 (4%)

Query: 30  LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGR-- 87
           +D +      +E+ ++K L HP++I+ Y     +  + +V E A  G++   ++ H +  
Sbjct: 71  MDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDL-SRMIKHFKKQ 129

Query: 88  ---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLF-TP 143
              + E+   + F Q+ +A+   H R ++HRD+K  N+ + A   +K+ D G    F + 
Sbjct: 130 KRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK 189

Query: 144 GQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTL 196
                +  G+P Y +PE      Y+  K DIWSLG +LY +     PF G  +
Sbjct: 190 TTAAHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQSPFYGDKM 241



>gi|2499600|sp|Q16539|MK14_HUMAN   Mitogen-activated protein kinase 14 (Mitogen-activated protein
           kinase p38alpha) (MAP kinase p38alpha) (Cytokine
           suppressive anti-inflammatory drug binding protein)
           (CSAID binding protein) (CSBP) (MAX-interacting protein
           2) (MAP kinase MXI2) (SAPK2A)
          Length = 360

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 79/332 (23%), Positives = 146/332 (43%), Gaps = 39/332 (11%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G +   F  +T   VA+K + +      + K+ +RE++++K + H ++I L  V    R 
Sbjct: 36  GSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARS 95

Query: 66  ------IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKA 119
                 +YLVT     G   +++V   ++ +   +    QI+  + + H  +I+HRDLK 
Sbjct: 96  LEEFNDVYLVTHLM--GADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKP 153

Query: 120 ENLLLDANLNIKIADFGFSNLF---TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176
            NL ++ +  +KI DFG +        G +   W     Y APE+     +    VDIWS
Sbjct: 154 SNLAVNEDCELKILDFGLARHTDDEMTGYVATRW-----YRAPEIMLNWMHYNQTVDIWS 208

Query: 177 LGVVLYVLVCGALPFDGST-LQNLR-------------ARVLSGKFRIPFFMSTGLVPEL 222
           +G ++  L+ G   F G+  +  L+              + +S +    +  S   +P++
Sbjct: 209 VGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKM 268

Query: 223 D-KRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQ 281
           +   +  G   +A    L+  MLVLD +KR++  Q   H +      DP+ + +     Q
Sbjct: 269 NFANVFIGANPLA--VDLLEKMLVLDSDKRITAAQALAHAYFAQYH-DPDDEPVADPYDQ 325

Query: 282 LKEERQV-----DPLNEDVLLAMEDMGLDKEQ 308
             E R +       L  D +++     LD+E+
Sbjct: 326 SFESRDLLIDEWKSLTYDEVISFVPPPLDQEE 357



>gi|29840818|sp|Q9UKE5|TNIK_HUMAN   TRAF2 and NCK interacting kinase
          Length = 1360

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 77/279 (27%), Positives = 129/279 (46%), Gaps = 42/279 (15%)

Query: 2   QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61
           QV KG  ++     T QL AIK++D T  +EE +K+   E+ ++K   H   I  Y    
Sbjct: 38  QVYKGRHVK-----TGQLAAIKVMDVTGDEEEEIKQ---EINMLKKYSHHRNIATYYGAF 89

Query: 62  TER-------MIYLVTEYASGGEIFDHL--VAHGRMAEKEARRKFKQIVTAVYFCHCRNI 112
            ++        ++LV E+   G + D +       + E+      ++I+  +   H   +
Sbjct: 90  IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149

Query: 113 VHRDLKAENLLLDANLNIKIADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE---- 166
           +HRD+K +N+LL  N  +K+ DFG S     T G+   T+ G+P + APE+    E    
Sbjct: 150 IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPDA 208

Query: 167 -YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKR 225
            YD  K D+WSLG+    +  GA P     +  +RA  L  +   P             R
Sbjct: 209 TYDF-KSDLWSLGITAIEMAEGAPPL--CDMHPMRALFLIPRNPAP-------------R 252

Query: 226 LKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
           LK+   S  + +  I   LV + ++R + EQ+ KH +++
Sbjct: 253 LKSKKWS-KKFQSFIESCLVKNHSQRPATEQLMKHPFIR 290



>gi|41688799|sp|Q9Y3S1|WNK2_HUMAN   Serine/threonine-protein kinase WNK2 (Protein kinase with no lysine
           2) (Protein kinase, lysine-deficient 2) (P/OKcl.13)
          Length = 2297

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 52/171 (30%), Positives = 89/171 (52%), Gaps = 13/171 (7%)

Query: 28  TQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET----ERMIYLVTEYASGGEIFDHLV 83
           T+L+ +  K+   E +++K L HP+I+R Y   E+    +R I LVTE  + G +  +L 
Sbjct: 232 TKLERQRFKE---EAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLK 288

Query: 84  AHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANL-NIKIADFGFSNL 140
               M  K  R   +QI+  + F H R   I+HRDLK +N+ +     ++KI D G + L
Sbjct: 289 RFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL 348

Query: 141 FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
                  K+  G+P + APE++E  E+    VD+++ G+ +  +     P+
Sbjct: 349 -KRASFAKSVIGTPEFMAPEMYE--EHYDESVDVYAFGMCMLEMATSEYPY 396



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 40/169 (23%), Positives = 58/169 (34%), Gaps = 32/169 (18%)

Query: 850  QQPPHYTTSALQQALLSPTPPDYTRHQQASSPTPPHGYAHQPALMHSESMEEDCSCEGAK 909
            +QPP   ++  +  L S   P +   QQ  S   P      P    + S     +     
Sbjct: 1378 KQPPD--SAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALP--- 1432

Query: 910  DGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQEL---------------G 954
               QD  + +T T     S      GGPG P+ L   +  +Q L               G
Sbjct: 1433 ---QDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVG 1489

Query: 955  IHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPA 1003
            + P    P AA +++    REP+         P  A E   H+G   PA
Sbjct: 1490 LAPCTPAPEAASTRDASAPREPL---------PPPAPEPSPHSGTPQPA 1529



>gi|29427834|sp|Q8N4C8|M4K6_HUMAN   Mitogen-activated protein kinase kinase kinase kinase 6 (MAPK/ERK
           kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6)
           (Misshapen/NIK-related kinase) (GCK family kinase MiNK)
          Length = 1332

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 63/205 (30%), Positives = 101/205 (49%), Gaps = 26/205 (12%)

Query: 2   QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61
           QV KG  ++     T QL AIK++D T+ +EE +K+   E+ ++K   H   I  Y    
Sbjct: 38  QVYKGRHVK-----TGQLAAIKVMDVTEDEEEEIKQ---EINMLKKYSHHRNIATYYGAF 89

Query: 62  TER-------MIYLVTEYASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNI 112
            ++        ++LV E+   G + D +      A KE    +  ++I+  +   H   +
Sbjct: 90  IKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKV 149

Query: 113 VHRDLKAENLLLDANLNIKIADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE---- 166
           +HRD+K +N+LL  N  +K+ DFG S     T G+   T+ G+P + APE+    E    
Sbjct: 150 IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPDA 208

Query: 167 -YDGPKVDIWSLGVVLYVLVCGALP 190
            YD  + DIWSLG+    +  GA P
Sbjct: 209 TYD-YRSDIWSLGITAIEMAEGAPP 232



>gi|400274|sp|Q02750|MP2K1_HUMAN   Dual specificity mitogen-activated protein kinase kinase 1 (MAP
           kinase kinase 1) (MAPKK 1) (ERK activator kinase 1)
           (MAPK/ERK kinase 1) (MEK1)
          Length = 393

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 66/265 (24%), Positives = 120/265 (45%), Gaps = 39/265 (14%)

Query: 37  KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRK 96
           +I RE+Q++     P+I+  Y    ++  I +  E+  GG +   L   GR+ E+   + 
Sbjct: 110 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKV 169

Query: 97  FKQIVTAV-YFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLL----KTWC 151
              ++  + Y      I+HRD+K  N+L+++   IK+ DFG S     GQL+     ++ 
Sbjct: 170 SIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSFV 224

Query: 152 GSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF---DGSTLQNLRARVLSG-- 206
           G+  Y +PE  +G  Y   + DIWS+G+ L  +  G  P    D   L+ +    + G  
Sbjct: 225 GTRSYMSPERLQGTHY-SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA 283

Query: 207 -----KFRIP-----------------FFMSTGLVPELDKRLKAGCLSIAECEHLIRHML 244
                + R P                 F +   +V E   +L +G  S+ E +  +   L
Sbjct: 284 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL-EFQDFVNKCL 342

Query: 245 VLDPNKRLSMEQICKHKWMKLGDAD 269
           + +P +R  ++Q+  H ++K  DA+
Sbjct: 343 IKNPAERADLKQLMVHAFIKRSDAE 367



>gi|20141296|sp|P08631|HCK_HUMAN   Tyrosine-protein kinase HCK (p59-HCK/p60-HCK) (Hemopoietic cell
           kinase)
          Length = 526

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 55/185 (29%), Positives = 93/185 (50%), Gaps = 12/185 (6%)

Query: 34  NLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEA 93
           +++    E  +MK L H  +++L+ V+ T+  IY++TE+ + G + D L +      K+ 
Sbjct: 298 SVEAFLAEANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDE--GSKQP 354

Query: 94  RRKF----KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKT 149
             K      QI   + F   RN +HRDL+A N+L+ A+L  KIADFG + +    +    
Sbjct: 355 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAR 414

Query: 150 WCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGSTLQNLRARVLSG 206
                P  + APE      +   K D+WS G++L  +V  G +P+ G +   +  R L  
Sbjct: 415 EGAKFPIKWTAPEAINFGSFT-IKSDVWSFGILLMEIVTYGRIPYPGMSNPEV-IRALER 472

Query: 207 KFRIP 211
            +R+P
Sbjct: 473 GYRMP 477



>gi|125370|sp|P06241|FYN_HUMAN   Proto-oncogene tyrosine-protein kinase FYN (P59-FYN) (SYN) (SLK)
          Length = 537

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 62/197 (31%), Positives = 96/197 (48%), Gaps = 11/197 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK +    +  E+      E QIMK L H  +++LY V+ +E  IY+VTEY + G + 
Sbjct: 296 VAIKTLKPGTMSPESF---LEEAQIMKKLKHDKLVQLYAVV-SEEPIYIVTEYMNKGSLL 351

Query: 80  DHLV-AHGRMAE-KEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           D L    GR  +         Q+   + +    N +HRDL++ N+L+   L  KIADFG 
Sbjct: 352 DFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGL 411

Query: 138 SNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS 194
           + L    +         P  + APE      +   K D+WS G++L  LV  G +P+ G 
Sbjct: 412 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILLTELVTKGRVPYPGM 470

Query: 195 TLQNLRARVLSGKFRIP 211
             + +  +V  G +R+P
Sbjct: 471 NNREVLEQVERG-YRMP 486



>gi|45593475|sp|Q12851|M4K2_HUMAN   Mitogen-activated protein kinase kinase kinase kinase 2 (MAPK/ERK
           kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2)
           (Germinal center kinase) (GC kinase) (Rab8 interacting
           protein) (B lymphocyte serine/threonine-protein kinase)
          Length = 819

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 62/249 (24%), Positives = 119/249 (47%), Gaps = 20/249 (8%)

Query: 16  TKQLVAIKIIDKTQLDE-ENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           T +L A+KI+   +LD  +++  + +E+ I++   HP+++           +++  E+  
Sbjct: 37  TSELAAVKIV---KLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCG 93

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIAD 134
           GG + +   A G + E++     ++ +  ++  H +  +HRD+K  NLLL    ++K+AD
Sbjct: 94  GGSLQEIYHATGPLEERQIAYVCRERLKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLAD 153

Query: 135 FGFSNLFTPG-QLLKTWCGSPPYAAPEL--FEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           FG S   T      +++ G+P + APE+   E K       D+W+LG+    L  G L  
Sbjct: 154 FGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIEL--GELQP 211

Query: 192 DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKR 251
               L  +RA +L  K       S+   P+L  + +          H ++  L  +P KR
Sbjct: 212 PLFHLHPMRALMLMSK-------SSFQPPKLRDKTR----WTQNFHHFLKLALTKNPKKR 260

Query: 252 LSMEQICKH 260
            + E++ +H
Sbjct: 261 PTAEKLLQH 269



>gi|543848|sp|P35626|ARBK2_HUMAN   Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (G-protein coupled
           receptor kinase 3)
          Length = 688

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 54/182 (29%), Positives = 95/182 (52%), Gaps = 7/182 (3%)

Query: 15  ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH----PHIIRLYQVMETERMIYLVT 70
           +T ++ A+K +DK ++  +  + +    +IM  L      P I+ +     T   +  + 
Sbjct: 212 DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFIL 271

Query: 71  EYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI 130
           +  +GG++  HL  HG  +EKE R    +I+  +   H R +V+RDLK  N+LLD + + 
Sbjct: 272 DLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHVHNRFVVYRDLKPANILLDEHGHA 331

Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGAL 189
           +I+D G +  F+  +   +  G+  Y APE+ + G  YD    D +SLG +L+ L+ G  
Sbjct: 332 RISDLGLACDFSKKKPHAS-VGTHGYMAPEVLQKGTAYDS-SADWFSLGCMLFKLLRGHS 389

Query: 190 PF 191
           PF
Sbjct: 390 PF 391



>gi|1174630|sp|P42680|TEC_HUMAN   Tyrosine-protein kinase Tec
          Length = 631

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 53/191 (27%), Positives = 90/191 (47%), Gaps = 8/191 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK I +  + EE+      E ++M  L HP +++LY V   ++ IY+VTE+   G + 
Sbjct: 395 VAIKAIREGAMCEEDF---IEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLL 451

Query: 80  DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
           + L    G  +        + +   + +    + +HRDL A N L+     +K++DFG +
Sbjct: 452 NFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMA 511

Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195
             F   Q   +     P  +  PE+F    +   K D+WS GV+++ V   G +PF+  T
Sbjct: 512 RYFLDDQYTSSSGAKFPVKWCPPEVFNYSRFSS-KSDVWSFGVLMWEVFTEGRMPFEKYT 570

Query: 196 LQNLRARVLSG 206
              +   V  G
Sbjct: 571 NYEVVTMVTRG 581



>gi|37537993|sp|Q9HC98|NEK6_HUMAN   Serine/threonine-protein kinase Nek6 (NimA-related protein kinase
           6) (Protein kinase SID6-1512)
          Length = 313

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 50/186 (26%), Positives = 91/186 (48%), Gaps = 7/186 (3%)

Query: 17  KQLVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           ++ VA+K +   ++ D +  +   +E+ ++K L HP+II+       +  + +V E A  
Sbjct: 68  RKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADA 127

Query: 76  GEIFDHLVAHGR----MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
           G++   +    +    + E+   + F Q+ +AV   H R ++HRD+K  N+ + A   +K
Sbjct: 128 GDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVK 187

Query: 132 IADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           + D G    F +      +  G+P Y +PE      Y+  K DIWSLG +LY +     P
Sbjct: 188 LGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNF-KSDIWSLGCLLYEMAALQSP 246

Query: 191 FDGSTL 196
           F G  +
Sbjct: 247 FYGDKM 252



>gi|585361|sp|Q08881|ITK_HUMAN   Tyrosine-protein kinase ITK/TSK (T-cell-specific kinase)
           (Tyrosine-protein kinase Lyk) (Kinase EMT)
          Length = 620

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 9/198 (4%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           K  VAIK I +  + EE+      E ++M  L HP +++LY V   +  I LV E+   G
Sbjct: 385 KDKVAIKTIREGAMSEEDF---IEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHG 441

Query: 77  EIFDHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
            + D+L    G  A +        +   + +     ++HRDL A N L+  N  IK++DF
Sbjct: 442 CLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDF 501

Query: 136 GFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFD 192
           G +      Q   +     P  +A+PE+F    Y   K D+WS GV+++ V   G +P++
Sbjct: 502 GMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS-KSDVWSFGVLMWEVFSEGKIPYE 560

Query: 193 GSTLQNLRARVLSGKFRI 210
             +   +   + +G FR+
Sbjct: 561 NRSNSEVVEDISTG-FRL 577



>gi|22653927|sp|O94921|PFTK1_HUMAN   Serine/threonine-protein kinase PFTAIRE-1
          Length = 469

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 63/262 (24%), Positives = 113/262 (43%), Gaps = 19/262 (7%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           +LVA+K+I + Q +E       RE  ++K L H +I+ L+ ++ T+  + LV EY    +
Sbjct: 159 KLVALKVI-RLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHT-D 216

Query: 78  IFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136
           +  ++  H G +     +    Q++  + + H R I+HRDLK +NLL+     +K+ADFG
Sbjct: 217 LCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFG 276

Query: 137 FSNL-FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG-S 194
            +     P         +  Y  P++  G       +D+W +G +   ++ G   F G  
Sbjct: 277 LARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMK 336

Query: 195 TLQNLRARVL-----------SGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH---LI 240
            +Q+   R+             G   +P F          K L+     ++   H   L 
Sbjct: 337 DIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLA 396

Query: 241 RHMLVLDPNKRLSMEQICKHKW 262
             +L   P  RLS +    H++
Sbjct: 397 SKLLQCSPKNRLSAQAALSHEY 418



>gi|1705485|sp|P51451|BLK_HUMAN   Tyrosine-protein kinase BLK (B lymphocyte kinase) (p55-BLK)
          Length = 505

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 66/215 (30%), Positives = 101/215 (46%), Gaps = 12/215 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + +  +  E       E  +MK L H  ++RLY V+ T+  IY+VTEY + G + 
Sbjct: 266 VAIKTLKEGTMSPE---AFLGEANMMKALQHERLVRLYAVV-TKEPIYIVTEYMARGCLL 321

Query: 80  DHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 137
           D L      R++         QI   + +    N +HRDL+A N+L+   L  KIADFG 
Sbjct: 322 DFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGL 381

Query: 138 SNLFTPGQLLKTWCGSP-PYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195
           + +       +     P  + APE      +   K D+WS GV+L  V+  G +P+ G +
Sbjct: 382 ARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFT-IKADVWSFGVLLMEVVTYGRVPYPGMS 440

Query: 196 LQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGC 230
              +  R L   +R+P        PEL + + A C
Sbjct: 441 NPEV-IRNLERGYRMP--RPDTCPPELYRGVIAEC 472



>gi|28201830|sp|Q96RU7|TRIB3_HUMAN   Tribbles homolog 3 (TRB-3) (Neuronal cell death inducible putative
           kinase)
          Length = 358

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 58/219 (26%), Positives = 95/219 (43%), Gaps = 23/219 (10%)

Query: 50  HPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHC 109
           H H+ R  +V+   +++Y      + G++   + +  R+ E EA   F+Q+ TA+  CH 
Sbjct: 117 HKHVARPTEVLAGTQLLYAFFT-RTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQ 175

Query: 110 RNIVHRDLKAENLLLDANLNIKIADFGFSN---LFTPGQLLKTWCGSPPYAAPELFEGK- 165
             +V RDLK    +       K+      +   L  P   L      P Y  PE+   + 
Sbjct: 176 HGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRA 235

Query: 166 EYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKR 225
            Y G   D+WSLGV L+ ++ G  PF  S    L  ++  G + +P              
Sbjct: 236 SYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALP-------------- 281

Query: 226 LKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
             AG  + A C  L+R +L  +P +RL+   I  H W++
Sbjct: 282 --AGLSAPARC--LVRCLLRREPAERLTATGILLHPWLR 316



>gi|547759|sp|Q06187|BTK_HUMAN   Tyrosine-protein kinase BTK (Bruton's tyrosine kinase)
           (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell
           progenitor kinase) (BPK)
          Length = 659

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 48/191 (25%), Positives = 94/191 (49%), Gaps = 8/191 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK+I +  + E+   +   E ++M  L H  +++LY V   +R I+++TEY + G + 
Sbjct: 427 VAIKMIKEGSMSED---EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLL 483

Query: 80  DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
           ++L     R   ++     K +  A+ +   +  +HRDL A N L++    +K++DFG S
Sbjct: 484 NYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS 543

Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195
                 +   +     P  ++ PE+    ++   K DIW+ GV+++ +   G +P++  T
Sbjct: 544 RYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSS-KSDIWAFGVLMWEIYSLGKMPYERFT 602

Query: 196 LQNLRARVLSG 206
                  +  G
Sbjct: 603 NSETAEHIAQG 613



>gi|29427585|sp|O95819|M4K4_HUMAN   Mitogen-activated protein kinase kinase kinase kinase 4 (MAPK/ERK
           kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4)
           (HPK/GCK-like kinase HGK) (Nck interacting kinase)
          Length = 1239

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 79/282 (28%), Positives = 129/282 (45%), Gaps = 37/282 (13%)

Query: 2   QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61
           QV KG  ++     T QL AIK++D T+ +EE +K    E+ ++K   H   I  Y    
Sbjct: 38  QVYKGRHVK-----TGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHHRNIATYYGAF 89

Query: 62  TER-------MIYLVTEYASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRN 111
            ++        ++LV E+   G I D LV + +   + E       ++I+  +   H  +
Sbjct: 90  IKKSPPGHDDQLWLVMEFCGAGSITD-LVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 148

Query: 112 IVHRDLKAENLLLDANLNIKIADFGFSNLF--TPGQLLKTWCGSPPYAAPELFEGKE--- 166
           ++HRD+K +N+LL  N  +K+ DFG S     T G+   T+ G+P + APE+    E   
Sbjct: 149 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR-RNTFIGTPYWMAPEVIACDENPD 207

Query: 167 --YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDK 224
             YD  + D+WS G+    +  GA P     +  +RA  L  +   P   S     +   
Sbjct: 208 ATYD-YRSDLWSCGITAIEMAEGAPPL--CDMHPMRALFLIPRNPPPRLKSKKWSKKFFS 264

Query: 225 RLKAGCL-----SIAECEHLIRHMLVLD-PNKRLSMEQICKH 260
            ++ GCL          E L++H  + D PN+R    Q+  H
Sbjct: 265 FIE-GCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDH 305



>gi|2499633|sp|Q13163|MP2K5_HUMAN   Dual specificity mitogen-activated protein kinase kinase 5 (MAP
           kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5)
          Length = 438

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 50/174 (28%), Positives = 86/174 (49%), Gaps = 7/174 (4%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G + + +   + +++A+K+I    +  E  K+I  E++I+      +II  Y     E  
Sbjct: 178 GTVYKAYHVPSGKILAVKVI-LLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENR 236

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125
           I + TE+  GG     L  + +M E    R    +V  + +     I+HRD+K  N+L++
Sbjct: 237 ISICTEFMDGGS----LDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVN 292

Query: 126 ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV 179
               +K+ DFG S       + KT+ G+  Y APE   G++Y G   D+WSLG+
Sbjct: 293 TRGQVKLCDFGVSTQLV-NSIAKTYVGTNAYMAPERISGEQY-GIHSDVWSLGI 344



>gi|125870|sp|P07947|YES_HUMAN   Proto-oncogene tyrosine-protein kinase YES (p61-YES) (C-YES)
          Length = 543

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 65/205 (31%), Positives = 96/205 (46%), Gaps = 27/205 (13%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK +    +  E      +E QIMK L H  ++ LY V+ +E  IY+VTE+ S G + 
Sbjct: 302 VAIKTLKPGTMMPE---AFLQEAQIMKKLRHDKLVPLYAVV-SEEPIYIVTEFMSKGSLL 357

Query: 80  DHLVAHGRMAEKEARRKF----------KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
           D L        KE   K+           QI   + +    N +HRDL+A N+L+  NL 
Sbjct: 358 DFL--------KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLV 409

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC- 186
            KIADFG + L    +         P  + APE      +   K D+WS G++   LV  
Sbjct: 410 CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILQTELVTK 468

Query: 187 GALPFDGSTLQNLRARVLSGKFRIP 211
           G +P+ G   + +  +V  G +R+P
Sbjct: 469 GRVPYPGMVNREVLEQVERG-YRMP 492



>gi|30316147|sp|Q9Y4K4|M4K5_HUMAN   Mitogen-activated protein kinase kinase kinase kinase 5 (MAPK/ERK
           kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
           (Kinase homologous to SPS1/STE20) (KHS)
          Length = 846

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 67/265 (25%), Positives = 124/265 (46%), Gaps = 22/265 (8%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T +L A+KII     D+ +L  I +E+ ++K   H +I+  +    +   +++  EY  G
Sbjct: 42  TGELAAVKIIKLEPGDDFSL--IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGG 99

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           G + D     G ++E +     ++ +  + + H +  +HRD+K  N+LL  + ++K+ADF
Sbjct: 100 GSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADF 159

Query: 136 GFSNLFTPG-QLLKTWCGSPPYAAPELFEGKEYDG--PKVDIWSLGVVLYVLVCGALPFD 192
           G +   T      K++ G+P + APE+   ++  G     DIW++G+    L  G L   
Sbjct: 160 GVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIEL--GELQPP 217

Query: 193 GSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRL 252
              L  +RA  L  K       S    P+L  + K      +   + ++  L  +P KR 
Sbjct: 218 MFDLHPMRALFLMSK-------SNFQPPKLKDKTKWS----STFHNFVKIALTKNPKKRP 266

Query: 253 SMEQICKHKWMKLGDADPNFDRLIA 277
           + E++  H ++    A P   R +A
Sbjct: 267 TAERLLTHTFV----AQPGLSRALA 287



>gi|114152|sp|P25098|ARBK1_HUMAN   Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (G-protein coupled
           receptor kinase 2)
          Length = 689

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 52/183 (28%), Positives = 96/183 (52%), Gaps = 7/183 (3%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCH----PHIIRLYQVMETERMIYLV 69
           ++T ++ A+K +DK ++  +  + +    +IM  L      P I+ +     T   +  +
Sbjct: 211 RDTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFI 270

Query: 70  TEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
            +  +GG++  HL  HG  +E + R    +I+  +   H R +V+RDLK  N+LLD + +
Sbjct: 271 LDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGH 330

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGA 188
           ++I+D G +  F+  +   +  G+  Y APE+ + G  YD    D +SLG +L+ L+ G 
Sbjct: 331 VRISDLGLACDFSKKKPHAS-VGTHGYMAPEVLQKGVAYDS-SADWFSLGCMLFKLLRGH 388

Query: 189 LPF 191
            PF
Sbjct: 389 SPF 391



>gi|125387|sp|P29320|EPHA3_HUMAN   Ephrin type-A receptor 3 precursor (Tyrosine-protein kinase
           receptor ETK1) (HEK) (HEK4)
          Length = 983

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 59/198 (29%), Positives = 96/198 (48%), Gaps = 9/198 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + K    E+  +    E  IM    HP+IIRL  V+   + + +VTEY   G + 
Sbjct: 650 VAIKTL-KVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLD 708

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L  H  +    +     + I + + +      VHRDL A N+L+++NL  K++DFG S
Sbjct: 709 SFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLS 768

Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193
            +    P     T  G  P  + +PE    +++     D+WS G+VL+ V+  G  P+  
Sbjct: 769 RVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSAS-DVWSYGIVLWEVMSYGERPYWE 827

Query: 194 STLQNLRARVLSGKFRIP 211
            + Q++   V  G +R+P
Sbjct: 828 MSNQDVIKAVDEG-YRLP 844



>gi|3183518|sp|Q05397|FAK1_HUMAN   Focal adhesion kinase 1 (FADK 1) (pp125FAK) (Protein-tyrosine
           kinase 2)
          Length = 1052

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 55/196 (28%), Positives = 94/196 (47%), Gaps = 8/196 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK       D    +K  +E   M+   HPHI++L  V+ TE  ++++ E  + GE+ 
Sbjct: 451 VAIKTCKNCTSDSVR-EKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELR 508

Query: 80  DHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L       +  +   +  Q+ TA+ +   +  VHRD+ A N+L+ +N  +K+ DFG S
Sbjct: 509 SFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLS 568

Query: 139 NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGST 195
                    K   G  P  + APE    + +     D+W  GV ++ +L+ G  PF G  
Sbjct: 569 RYMEDSTYYKASKGKLPIKWMAPESINFRRFTSAS-DVWMFGVCMWEILMHGVKPFQGVK 627

Query: 196 LQNLRARVLSGKFRIP 211
             ++  R+ +G+ R+P
Sbjct: 628 NNDVIGRIENGE-RLP 642



>gi|400127|sp|P07332|FES_HUMAN   Proto-oncogene tyrosine-protein kinase Fes/Fps (C-Fes)
          Length = 822

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 67/231 (29%), Positives = 101/231 (43%), Gaps = 13/231 (5%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G +    L+    LVA+K   +T L  +   K  +E +I+K   HP+I+RL  V   ++ 
Sbjct: 573 GEVFSGRLRADNTLVAVKSCRET-LPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQP 631

Query: 66  IYLVTEYASGGEIFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124
           IY+V E   GG+    L   G R+  K   +        + +   +  +HRDL A N L+
Sbjct: 632 IYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLV 691

Query: 125 DANLNIKIADFGFSNLFTPGQLLKTWCGS----PPYAAPELFEGKEYDGPKVDIWSLGVV 180
                +KI+DFG S     G    +  GS      + APE      Y   + D+WS G++
Sbjct: 692 TEKNVLKISDFGMSREEADGVYAASG-GSRQVPVKWTAPEALNYGRYSS-ESDVWSFGIL 749

Query: 181 LY-VLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGC 230
           L+     GA P+   + Q  R  V  G  R+P      L P+   RL   C
Sbjct: 750 LWETFSLGASPYPNLSNQQTREFVEKGG-RLP---CPELCPDAVFRLMEQC 796



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 19/93 (20%), Positives = 45/93 (48%), Gaps = 1/93 (1%)

Query: 1170 PVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAE 1229
            P++Q  W  +  +TEGL + + +  E++ +     L    ++ Q+  + Y ++ + L+ E
Sbjct: 68   PISQS-WAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQE 126

Query: 1230 LQEGARQKLHELQEKLSPLGEEMRDRARAHVDA 1262
            L +   Q + +L+ +   L  +     R + +A
Sbjct: 127  LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA 159



>gi|21263659|sp|Q8WTQ7|GRK7_HUMAN   G protein-coupled receptor kinase 7 (G protein-coupled receptor
           kinase GRK7)
          Length = 553

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 52/182 (28%), Positives = 92/182 (50%), Gaps = 3/182 (1%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71
           ++ T ++ A K +DK +L ++  +K+   E +I++ +  P I+ L    E++  + LV  
Sbjct: 210 VKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMS 269

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
             +GG++  H+   G      +R  F   QI   +   H   IV+RD+K EN+LLD   N
Sbjct: 270 LMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGN 329

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
            +++D G +     G+ +    G+  Y APE+   K      VD +++G  +Y +V G  
Sbjct: 330 CRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRT 389

Query: 190 PF 191
           PF
Sbjct: 390 PF 391



>gi|399448|sp|P31152|MK04_HUMAN   Mitogen-activated protein kinase 4 (Extracellular signal-regulated
           kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)
          Length = 557

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 79/355 (22%), Positives = 149/355 (41%), Gaps = 57/355 (16%)

Query: 4   VKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE 63
           V G ++        + VA+K I  +  D  ++K   RE++I++ L H +I+++Y+V+  +
Sbjct: 30  VNGLVLSAVDSRACRKVAVKKIALS--DARSMKHALREIKIIRRLDHDNIVKVYEVLGPK 87

Query: 64  -----------RMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 112
                       + Y+V EY         L+  G +AE+ A+    Q++  + + H  N+
Sbjct: 88  GTDLQGELFKFSVAYIVQEYMETD--LARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANV 145

Query: 113 VHRDLKAENLLLDA-NLNIKIADFGFSNL----FTPGQLLKTWCGSPPYAAPELFEGKEY 167
           +HRDLK  N+ +   +L +KI DFG + +    ++    L     +  Y +P L      
Sbjct: 146 LHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNN 205

Query: 168 DGPKVDIWSLGVVLYVLVCGALPFDGS-----------TLQNLRARVLSGKFRI-PFFMS 215
               +D+W+ G +L  ++ G + F G+           T+  +R        R+ P F+S
Sbjct: 206 YTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVS 265

Query: 216 T---------GLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266
           +          L+PE++          +E    +  +L  +P  RL+ E   +H +M   
Sbjct: 266 STWEVKRPLRKLLPEVN----------SEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPY 315

Query: 267 DADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQPDGTLNLDSD 321
               +      E       R  D +++ VL+A     L    T      ++L SD
Sbjct: 316 SCPED------EPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSD 364



>gi|729887|sp|P41240|CSK_HUMAN   Tyrosine-protein kinase CSK (C-SRC kinase) (Protein-tyrosine kinase
           CYL)
          Length = 450

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 55/192 (28%), Positives = 96/192 (50%), Gaps = 15/192 (7%)

Query: 23  KIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-IYLVTEYASGGEIFDH 81
           K+  K   ++   +    E  +M  L H ++++L  V+  E+  +Y+VTEY + G + D+
Sbjct: 218 KVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDY 277

Query: 82  LVAHGR-MAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF-- 137
           L + GR +   +   KF   +  A+ +    N VHRDL A N+L+  +   K++DFG   
Sbjct: 278 LRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337

Query: 138 --SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGS 194
             S+    G+L   W       APE    K++   K D+WS G++L+ +   G +P+   
Sbjct: 338 EASSTQDTGKLPVKW------TAPEALREKKF-STKSDVWSFGILLWEIYSFGRVPYPRI 390

Query: 195 TLQNLRARVLSG 206
            L+++  RV  G
Sbjct: 391 PLKDVVPRVEKG 402



>gi|20141243|sp|P50750|CDK9_HUMAN   Cell division protein kinase 9 (Cyclin-dependent kinase 9)
           (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell
           division cycle 2-like protein kinase 4)
          Length = 372

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 68/283 (24%), Positives = 125/283 (44%), Gaps = 45/283 (15%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM-------- 65
           ++T Q VA+K +      E       RE++I+++L H +++ L ++  T+          
Sbjct: 39  RKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGS 98

Query: 66  IYLVTEYAS---GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENL 122
           IYLV ++      G + + LV   +    E +R  + ++  +Y+ H   I+HRD+KA N+
Sbjct: 99  IYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANV 155

Query: 123 LLDANLNIKIADFGFSNLFT----------PGQLLKTWCGSPPYAAPELFEGKEYDGPKV 172
           L+  +  +K+ADFG +  F+            +++  W     Y  PEL  G+   GP +
Sbjct: 156 LITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW-----YRPPELLLGERDYGPPI 210

Query: 173 DIWSLGVVLYVLVCGALPFDGSTLQNLRARV--LSGKFRIPFF-------------MSTG 217
           D+W  G ++  +   +     +T Q+  A +  L G      +             +  G
Sbjct: 211 DLWGAGCIMAEMWTRSPIMQANTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKG 270

Query: 218 LVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKH 260
              ++  RLKA        + LI  +LVLDP +R+  +    H
Sbjct: 271 QKRKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRIDSDDALNH 312



>gi|1706628|sp|P54756|EPHA5_HUMAN   Ephrin type-A receptor 5 precursor (Tyrosine-protein kinase
           receptor EHK-1) (Eph homology kinase-1) (Receptor
           protein-tyrosine kinase HEK7)
          Length = 1037

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 59/198 (29%), Positives = 95/198 (47%), Gaps = 9/198 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + K    E+  +    E  IM    HP+II L  V+   + + +VTEY   G + 
Sbjct: 704 VAIKTL-KVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLD 762

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L  + G+    +     + I   + +      VHRDL A N+L+++NL  K++DFG S
Sbjct: 763 TFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLS 822

Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDG 193
            +    P     T  G  P  + APE    +++     D+WS G+V++ +V  G  P+  
Sbjct: 823 RVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSAS-DVWSYGIVMWEVVSYGERPYWE 881

Query: 194 STLQNLRARVLSGKFRIP 211
            T Q++   V  G +R+P
Sbjct: 882 MTNQDVIKAVEEG-YRLP 898



>gi|46577075|sp|Q8NEV4|MYO3A_HUMAN   Myosin IIIA
          Length = 1616

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 76/275 (27%), Positives = 121/275 (44%), Gaps = 37/275 (13%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETE 63
           G + +   ++  Q  A+KI+D    +DEE    I  E  I+K L  HP+++R Y +   +
Sbjct: 33  GKVFKVLNKKNGQKAAVKILDPIHDIDEE----IEAEYNILKALSDHPNVVRFYGIYFKK 88

Query: 64  RMI-----YLVTEYASGGEIFD----HLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVH 114
             +     +LV E  SGG + D     L    RM+E        + +  +   H    +H
Sbjct: 89  DKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIH 148

Query: 115 RDLKAENLLLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPPYAAPELFEGKE-----YD 168
           RD+K  N+LL     +K+ DFG S  L +      T  G+P + APE+   ++     YD
Sbjct: 149 RDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYD 208

Query: 169 GPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKA 228
             + D WSLG+    L  G  P   + L  +RA      F+IP             +L+ 
Sbjct: 209 A-RCDTWSLGITAIELGDGDPPL--ADLHPMRA-----LFKIP--------RNPPPKLRQ 252

Query: 229 GCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWM 263
             L  AE    I   L  D  KR ++ ++ +HK++
Sbjct: 253 PELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287



>gi|18202489|sp|Q12852|M3K12_HUMAN   Mitogen-activated protein kinase kinase kinase 12 (Leucine-zipper
           protein kinase) (ZPK)
          Length = 859

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 44/151 (29%), Positives = 78/151 (51%), Gaps = 1/151 (0%)

Query: 41  EVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQI 100
           +++ ++ L HP+II    V        ++ E+ + G++++ L A   +           I
Sbjct: 161 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGI 220

Query: 101 VTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPE 160
              + + H   I+HRDLK+ N+L+  +  +KI+DFG S   +      ++ G+  + APE
Sbjct: 221 AGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPE 280

Query: 161 LFEGKEYDGPKVDIWSLGVVLYVLVCGALPF 191
           +    E    KVDIWS GVVL+ L+ G +P+
Sbjct: 281 VIR-NEPVSEKVDIWSFGVVLWELLTGEIPY 310



>gi|20455502|sp|P49841|GSK3B_HUMAN   Glycogen synthase kinase-3 beta (GSK-3 beta)
          Length = 420

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 63/202 (31%), Positives = 98/202 (48%), Gaps = 20/202 (9%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRL----YQVME 61
           G + Q  L ++ +LVAIK +    L ++  K   RE+QIM+ L H +I+RL    Y   E
Sbjct: 68  GVVYQAKLCDSGELVAIKKV----LQDKRFKN--RELQIMRKLDHCNIVRLRYFFYSSGE 121

Query: 62  TERMIYL--VTEYASGGEIFDHLVAHGRMAEKE-----ARRKFKQIVTAVYFCHCRNIVH 114
            +  +YL  V +Y    E    +  H   A++       +    Q+  ++ + H   I H
Sbjct: 122 KKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICH 179

Query: 115 RDLKAENLLLDANLNI-KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD 173
           RD+K +NLLLD +  + K+ DFG +     G+   ++  S  Y APEL  G       +D
Sbjct: 180 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSID 239

Query: 174 IWSLGVVLYVLVCGALPFDGST 195
           +WS G VL  L+ G   F G +
Sbjct: 240 VWSAGCVLAELLLGQPIFPGDS 261



>gi|48428273|sp|Q9UPZ9|ICK_HUMAN   Serine/threonine kinase ICK (Intestinal cell kinase) (hICK)
           (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2)
           (LCK2)
          Length = 632

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 73/273 (26%), Positives = 117/273 (42%), Gaps = 31/273 (11%)

Query: 15  ETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS 74
           E+ +L+AIK + +     E    + REV+ +K L H ++++L +V+     +Y + EY  
Sbjct: 25  ESGELIAIKKMKRKFYSWEECMNL-REVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMK 83

Query: 75  GGEIFDHLVAHGRMAEKEARRKFK-QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
              ++  +    ++  + A R    QI+  + F H     HRDLK ENLL      +KIA
Sbjct: 84  EN-LYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIA 142

Query: 134 DFGFSNLFTPGQLLKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVVL---YVL----- 184
           DFG +           +  +  Y APE L     Y  P +D+W++G ++   Y L     
Sbjct: 143 DFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSP-IDVWAVGCIMAEVYTLRPLFP 201

Query: 185 ----------VCGALPFDGSTLQNLRARVLSG-KFRIPFFMSTGLVPELDKRLKAGCLSI 233
                     +C  L     T      ++ S   FR P       VP   K L     S 
Sbjct: 202 GASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWP-----QCVPNNLKTLIPNASS- 255

Query: 234 AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266
            E   L+R ML  DP KR +  Q  ++ + ++G
Sbjct: 256 -EAVQLLRDMLQWDPKKRPTASQALRYPYFQVG 287



>gi|125358|sp|P09769|FGR_HUMAN   Proto-oncogene tyrosine-protein kinase FGR (P55-FGR) (C-FGR)
          Length = 529

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 53/176 (30%), Positives = 86/176 (48%), Gaps = 7/176 (3%)

Query: 36  KKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLV-AHGR-MAEKEA 93
           K    E Q+MK+L H  +++LY V+ +E  IY+VTE+   G + D L    G+ +   + 
Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVV-SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQL 359

Query: 94  RRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS 153
                Q+   + +    N +HRDL+A N+L+   L  KIADFG + L    +        
Sbjct: 360 VDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSK 419

Query: 154 PP--YAAPELFEGKEYDGPKVDIWSLGVVLYVLVC-GALPFDGSTLQNLRARVLSG 206
            P  + APE      +   K D+WS G++L  L+  G +P+ G   + +  +V  G
Sbjct: 420 FPIKWTAPEAALFGRFT-IKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQG 474



>gi|120049|sp|P21802|FGFR2_HUMAN   Fibroblast growth factor receptor 2 precursor (FGFR-2)
           (Keratinocyte growth factor receptor 2)
          Length = 821

 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 58/201 (28%), Positives = 100/201 (49%), Gaps = 23/201 (11%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI 78
           VA+K++ K    E++L  +  E+++MKM+  H +II L      +  +Y++ EYAS G +
Sbjct: 514 VAVKML-KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 572

Query: 79  FDHLVAHGRMAEK---------EARRKFKQIVTAVY-------FCHCRNIVHRDLKAENL 122
            ++L A      +         E +  FK +V+  Y       +   +  +HRDL A N+
Sbjct: 573 REYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNV 632

Query: 123 LLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGV 179
           L+  N  +KIADFG + ++       KT  G  P  + APE    + Y   + D+WS GV
Sbjct: 633 LVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT-HQSDVWSFGV 691

Query: 180 VLY-VLVCGALPFDGSTLQNL 199
           +++ +   G  P+ G  ++ L
Sbjct: 692 LMWEIFTLGGSPYPGIPVEEL 712



>gi|232066|sp|P27361|MK03_HUMAN   Mitogen-activated protein kinase 3 (Extracellular signal-regulated
           kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP
           kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK)
           (Microtubule-associated protein-2 kinase)
          Length = 379

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 62/271 (22%), Positives = 117/271 (43%), Gaps = 27/271 (9%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM-----ETERMIYLVTE 71
           K  VAIK I   +  +   ++  RE+QI+    H ++I +  ++     E  R +Y+V +
Sbjct: 65  KTRVAIKKISPFE-HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQD 123

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIK 131
                     L+   +++         QI+  + + H  N++HRDLK  NLL++   ++K
Sbjct: 124 LMETD--LYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLK 181

Query: 132 IADFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187
           I DFG + +  P       L  +  +  Y APE+    +     +DIWS+G +L  ++  
Sbjct: 182 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 241

Query: 188 ALPFDGSTLQNLRARVLSGKFRIPF---------FMSTGLVPELDKRLKAGCLSI----- 233
              F G    +    +L G    P            +   +  L  + K     +     
Sbjct: 242 RPIFPGKHYLDQLNHIL-GILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300

Query: 234 AECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
           ++   L+  ML  +PNKR+++E+   H +++
Sbjct: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLE 331



>gi|1706663|sp|P54762|EPHB1_HUMAN   Ephrin type-B receptor 1 precursor (Tyrosine-protein kinase
           receptor EPH-2) (NET) (HEK6) (ELK)
          Length = 984

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 55/200 (27%), Positives = 94/200 (47%), Gaps = 11/200 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + K    E+  +    E  IM    HP+IIRL  V+   R + ++TE+   G + 
Sbjct: 648 VAIKTL-KAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALD 706

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L  + G+    +     + I   + +    N VHRDL A N+L+++NL  K++DFG S
Sbjct: 707 SFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLS 766

Query: 139 NLFTPGQLLKTWCGS------PPYAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF 191
                     T+  S        + APE    +++     D+WS G+V++ V+  G  P+
Sbjct: 767 RYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSFGERPY 825

Query: 192 DGSTLQNLRARVLSGKFRIP 211
              + Q++    +   +R+P
Sbjct: 826 WDMSNQDV-INAIEQDYRLP 844



>gi|1705722|sp|P50613|CDK7_HUMAN   Cell division protein kinase 7 (CDK-activating kinase) (CAK) (TFIIH
           basal transcription factor complex kinase subunit) (39
           kDa protein kinase) (P39 Mo15) (STK1) (CAK1)
          Length = 346

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 53/178 (29%), Positives = 90/178 (50%), Gaps = 8/178 (4%)

Query: 14  QETKQLVAIKIID---KTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVT 70
           + T Q+VAIK I    +++  +   +   RE+++++ L HP+II L      +  I LV 
Sbjct: 32  KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVF 91

Query: 71  EYASGGEIFDHLVAHGRMAEKEARRKFKQIVT--AVYFCHCRNIVHRDLKAENLLLDANL 128
           ++       + ++    +    +  K   ++T   + + H   I+HRDLK  NLLLD N 
Sbjct: 92  DFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG 149

Query: 129 NIKIADFGFSNLF-TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLV 185
            +K+ADFG +  F +P +       +  Y APEL  G    G  VD+W++G +L  L+
Sbjct: 150 VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207



>gi|13432166|sp|P20794|MAK_HUMAN   Serine/threonine-protein kinase MAK (Male germ cell-associated
           kinase)
          Length = 623

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 70/276 (25%), Positives = 119/276 (43%), Gaps = 19/276 (6%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G ++     E+ +LVAIK + +     +    + REV+ +K L H ++I+L +V+     
Sbjct: 16  GSVLMGKSNESGELVAIKRMKRKFYSWDECMNL-REVKSLKKLNHANVIKLKEVIRENDH 74

Query: 66  IYLVTEYASGGEIFDHLVAHGRM-AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL 124
           +Y + EY     ++  +    ++  E   R    QI+  + F H     HRD+K ENLL 
Sbjct: 75  LYFIFEYMKEN-LYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLC 133

Query: 125 DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVVLYV 183
                +KIADFG +           +  +  Y APE L     Y  P +D+W++G ++  
Sbjct: 134 MGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP-IDVWAVGSIMAE 192

Query: 184 LVCGALPFDGSTLQN---LRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSI------- 233
           L      F G++  +      +VL    +  +     L   ++ R    C+ I       
Sbjct: 193 LYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ-CVPINLKTLIP 251

Query: 234 ---AECEHLIRHMLVLDPNKRLSMEQICKHKWMKLG 266
               E   L+  ML  DP KR +  Q  KH + ++G
Sbjct: 252 NASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVG 287



>gi|14548079|sp|Q14164|IKKE_HUMAN   Inhibitor of nuclear factor kappa-B kinase epsilon subunit (I
           kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK-E)
           (Inducible I kappa-B kinase) (IKK-i)
          Length = 716

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 53/194 (27%), Positives = 92/194 (47%), Gaps = 17/194 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIYLVTE 71
           +++ +LVA+K+ + T        ++ RE ++++ L H +I++L+ V ET   R   LV E
Sbjct: 29  KKSGELVAVKVFNTTSYLRPREVQV-REFEVLRKLNHQNIVKLFAVEETGGSRQKVLVME 87

Query: 72  YASGGEIFDHLVAHGR---MAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL---- 124
           Y S G +   L +      + E E     + +V  +       IVHRD+K  N++     
Sbjct: 88  YCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGE 147

Query: 125 DANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK-------VDIWSL 177
           +     K+ DFG +      +   +  G+  Y  P+++E      P+       VD+WS+
Sbjct: 148 EGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSI 207

Query: 178 GVVLYVLVCGALPF 191
           GV LY    G+LPF
Sbjct: 208 GVTLYHAATGSLPF 221



>gi|119554|sp|P28482|MK01_HUMAN   Mitogen-activated protein kinase 1 (Extracellular signal-regulated
           kinase 2) (ERK-2) (Mitogen-activated protein kinase 2)
           (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1)
          Length = 360

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 78/326 (23%), Positives = 139/326 (42%), Gaps = 54/326 (16%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM----- 60
           G +   +    K  VAIK I   +  +   ++  RE++I+    H +II +  ++     
Sbjct: 37  GMVCSAYDNVNKVRVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTI 95

Query: 61  ETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAE 120
           E  + +Y+V +          L+    ++         QI+  + + H  N++HRDLK  
Sbjct: 96  EQMKDVYIVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPS 153

Query: 121 NLLLDANLNIKIADFGFSNLFTPGQ----LLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176
           NLLL+   ++KI DFG + +  P       L  +  +  Y APE+    +     +DIWS
Sbjct: 154 NLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWS 213

Query: 177 LGVVLYVLVCGALPFDG----------------------STLQNLRAR----VLSGKFRI 210
           +G +L  ++     F G                      + + NL+AR     L  K ++
Sbjct: 214 VGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKV 273

Query: 211 PFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADP 270
           P+     L P  D          ++   L+  ML  +P+KR+ +EQ   H +++    DP
Sbjct: 274 PW---NRLFPNAD----------SKALDLLDKMLTFNPHKRIEVEQALAHPYLE-QYYDP 319

Query: 271 NFDRLIAECQQLKEERQVDPLNEDVL 296
           + D  IAE    K + ++D L ++ L
Sbjct: 320 S-DEPIAEA-PFKFDMELDDLPKEKL 343



>gi|1177044|sp|P43403|ZAP70_HUMAN   Tyrosine-protein kinase ZAP-70 (70 kDa zeta-associated protein)
           (Syk-related tyrosine kinase)
          Length = 619

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 59/194 (30%), Positives = 92/194 (47%), Gaps = 9/194 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK++ K   ++ + +++ RE QIM  L +P+I+RL  V + E ++ LV E A GG + 
Sbjct: 366 VAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM-LVMEMAGGGPLH 423

Query: 80  DHLVA-HGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             LV     +          Q+   + +   +N VHRDL A N+LL      KI+DFG S
Sbjct: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483

Query: 139 NLFTPGQLLKT--WCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193
                     T    G  P  + APE    +++   + D+WS GV ++  L  G  P+  
Sbjct: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-RSDVWSYGVTMWEALSYGQKPYKK 542

Query: 194 STLQNLRARVLSGK 207
                + A +  GK
Sbjct: 543 MKGPEVMAFIEQGK 556



>gi|547915|sp|P36507|MP2K2_HUMAN   Dual specificity mitogen-activated protein kinase kinase 2 (MAP
           kinase kinase 2) (MAPKK 2) (ERK activator kinase 2)
           (MAPK/ERK kinase 2) (MEK2)
          Length = 400

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 50/171 (29%), Positives = 81/171 (47%), Gaps = 13/171 (7%)

Query: 37  KIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRK 96
           +I RE+Q++     P+I+  Y    ++  I +  E+  GG + D ++   +   +E   K
Sbjct: 114 QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSL-DQVLKEAKRIPEEILGK 172

Query: 97  FKQIVTA--VYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLL----KTW 150
               V     Y      I+HRD+K  N+L+++   IK+ DFG S     GQL+     ++
Sbjct: 173 VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSF 227

Query: 151 CGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRA 201
            G+  Y APE  +G  Y   + DIWS+G+ L  L  G  P      + L A
Sbjct: 228 VGTRSYMAPERLQGTHY-SVQSDIWSMGLSLVELAVGRYPIPPPDAKELEA 277



>gi|120046|sp|P11362|FGFR1_HUMAN   Basic fibroblast growth factor receptor 1 precursor (FGFR-1)
           (bFGF-R) (Fms-like tyrosine kinase-2) (c-fgr)
          Length = 822

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 57/201 (28%), Positives = 100/201 (49%), Gaps = 23/201 (11%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETERMIYLVTEYASGGEI 78
           VA+K++ K+   E++L  +  E+++MKM+  H +II L      +  +Y++ EYAS G +
Sbjct: 511 VAVKML-KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569

Query: 79  FDHLVA---------HGRMAEKEARRKFKQIVTAVY-------FCHCRNIVHRDLKAENL 122
            ++L A         +      E +   K +V+  Y       +   +  +HRDL A N+
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629

Query: 123 LLDANLNIKIADFGFS-NLFTPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGV 179
           L+  +  +KIADFG + ++       KT  G  P  + APE    + Y   + D+WS GV
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT-HQSDVWSFGV 688

Query: 180 VLY-VLVCGALPFDGSTLQNL 199
           +L+ +   G  P+ G  ++ L
Sbjct: 689 LLWEIFTLGGSPYPGVPVEEL 709



>gi|1711371|sp|P54764|EPHA4_HUMAN   Ephrin type-A receptor 4 precursor (Tyrosine-protein kinase
           receptor SEK) (Receptor protein-tyrosine kinase HEK8)
          Length = 986

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/198 (28%), Positives = 97/198 (48%), Gaps = 9/198 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK +     D++  +    E  IM    HP+II L  V+   + + ++TEY   G + 
Sbjct: 650 VAIKTLKAGYTDKQR-RDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLD 708

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L  + GR    +     + I + + +    + VHRDL A N+L+++NL  K++DFG S
Sbjct: 709 AFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMS 768

Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193
            +    P     T  G  P  + APE    +++     D+WS G+V++ V+  G  P+  
Sbjct: 769 RVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSYGERPYWD 827

Query: 194 STLQNLRARVLSGKFRIP 211
            + Q++   +  G +R+P
Sbjct: 828 MSNQDVIKAIEEG-YRLP 844



>gi|6166188|sp|P32298|GRK4_HUMAN   G protein-coupled receptor kinase 4 (G protein-coupled receptor
           kinase GRK4) (ITI1)
          Length = 578

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 49/182 (26%), Positives = 90/182 (49%), Gaps = 4/182 (2%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLKKI-FREVQIMKMLCHPHIIRLYQVMETERMIYLVTE 71
           ++ T ++ A K + K ++ +   + +   E +I++ +    ++ L    ET+  + LV  
Sbjct: 206 VRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLT 265

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLN 129
             +GG++  H+   G     E R  F   ++   +       IV+RDLK EN+LLD   +
Sbjct: 266 IMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGH 325

Query: 130 IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL 189
           I+I+D G +     GQ ++   G+  Y APE+   ++Y     D W LG ++Y ++ G  
Sbjct: 326 IRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTF-SPDWWGLGCLIYEMIQGHS 384

Query: 190 PF 191
           PF
Sbjct: 385 PF 386



>gi|52783106|sp|O95835|LATS1_HUMAN   Serine/threonine protein kinase LATS1 (Large tumor suppressor
           homolog 1) (WARTS protein kinase) (h-warts)
          Length = 1130

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 50/256 (19%)

Query: 15  ETKQLVAIKIIDKTQLDEEN-LKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           +TK L A K + K  +   N +  +  E  I+    +  ++RLY   + +  +Y V +Y 
Sbjct: 726 DTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYI 785

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
            GG++   L+  G   E  AR    ++  AV   H    +HRD+K +N+L+D + +IK+ 
Sbjct: 786 PGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLT 845

Query: 134 DFG--------------------------FSNLFTP------GQLLK------------- 148
           DFG                          FSN +        G  LK             
Sbjct: 846 DFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRC 905

Query: 149 ---TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLS 205
              +  G+P Y APE+     Y     D WS+GV+L+ ++ G  PF   T    + +V++
Sbjct: 906 LAHSLVGTPNYIAPEVLLRTGYT-QLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVIN 964

Query: 206 GKFRIPFFMSTGLVPE 221
            +  +       L PE
Sbjct: 965 WQTSLHIPPQAKLSPE 980



>gi|2499603|sp|Q15759|MK11_HUMAN   Mitogen-activated protein kinase 11 (Mitogen-activated protein
           kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2)
           (Stress-activated protein kinase-2)
          Length = 372

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 75/335 (22%), Positives = 142/335 (42%), Gaps = 48/335 (14%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQV------ 59
           G +   +    +Q VA+K + +      + ++ +RE++++K L H ++I L  V      
Sbjct: 36  GSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATS 95

Query: 60  METERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFK--------QIVTAVYFCHCRN 111
           +E    +YLVT     G   +++V     A + AR            Q++  + + H   
Sbjct: 96  IEDFSEVYLVTTLM--GADLNNIVKCQAGAHQGARLALDEHVQFLVYQLLRGLKYIHSAG 153

Query: 112 IVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPK 171
           I+HRDLK  N+ ++ +  ++I DFG +      + +  +  +  Y APE+     +    
Sbjct: 154 IIHRDLKPSNVAVNEDCELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMHYNQT 211

Query: 172 VDIWSLGVVLYVLVCGALPFDGSTLQNLRARV--------------LSGKFRIPFFMSTG 217
           VDIWS+G ++  L+ G   F GS   +   R+              +S +    +  S  
Sbjct: 212 VDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLP 271

Query: 218 LVPELD-KRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLI 276
            +P+ D   +  G   +A    L+  MLVLD ++R+S  +   H +              
Sbjct: 272 PMPQKDLSSIFRGANPLA--IDLLGRMLVLDSDQRVSAAEALAHAY-------------F 316

Query: 277 AECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQ 311
           ++    ++E + +P +E V      +   KE T Q
Sbjct: 317 SQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQ 351



>gi|20455241|sp|Q9Y572|RIPK3_HUMAN   Receptor-interacting serine/threonine-protein kinase 3 (RIP-like
           protein kinase 3) (Receptor-interacting protein 3)
           (RIP-3)
          Length = 518

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/180 (31%), Positives = 88/180 (48%), Gaps = 21/180 (11%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET-----ERMIYLVTEYAS 74
           VA+KI+        N K I REV+ M  L +  ++RL  V+E      +    LVT++  
Sbjct: 47  VAVKIV--------NSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFME 98

Query: 75  GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKI 132
            G +   L +          R  K++V  +++ H +N  ++HRDLK  N+L D  L++K+
Sbjct: 99  NGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLPDPELHVKL 158

Query: 133 ADFGFSNLFTPGQLLKTWCGSP----PYAAPELFEGKEYDGPKV-DIWSLGVVLYVLVCG 187
           ADFG S  F  G    T  G P     Y APELF           D++S G++++ ++ G
Sbjct: 159 ADFGLST-FQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAG 217



>gi|17375734|sp|O14976|GAK_HUMAN   Cyclin G-associated kinase
          Length = 1311

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 74/259 (28%), Positives = 111/259 (42%), Gaps = 56/259 (21%)

Query: 31  DEENLKKIFREVQIMKMLC-HPHIIRLYQVMET--------ERMIYLVTEYASGG--EIF 79
           +EE  + I +EV  MK L  HP+I++               +    L+TE   G   E  
Sbjct: 75  EEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFL 134

Query: 80  DHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN--IVHRDLKAENLLLDANLNIKIADFGF 137
             + + G ++     + F Q   AV   H +   I+HRDLK ENLLL     IK+ DFG 
Sbjct: 135 KKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGS 194

Query: 138 SNLFT--PGQLLKTWCG--------------SPPYAAPELFE--GKEYDGPKVDIWSLGV 179
           +   +  P     +W                +P Y  PE+ +       G K DIW+LG 
Sbjct: 195 ATTISHYPDY---SWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGC 251

Query: 180 VLYVLVCGALPF-DGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEH 238
           +LY+L     PF DG+ L     R+++GK+ IP   +   V                   
Sbjct: 252 ILYLLCFRQHPFEDGAKL-----RIVNGKYSIPPHDTQYTV----------------FHS 290

Query: 239 LIRHMLVLDPNKRLSMEQI 257
           LIR ML ++P +RLS+ ++
Sbjct: 291 LIRAMLQVNPEERLSIAEV 309



>gi|12644190|sp|P29323|EPHB2_HUMAN   Ephrin type-B receptor 2 precursor (Tyrosine-protein kinase
           receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase
           HEK5) (ERK)
          Length = 1055

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 11/200 (5%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + K+   E+  +    E  IM    HP++I L  V+     + ++TE+   G + 
Sbjct: 650 VAIKTL-KSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLD 708

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L  + G+    +     + I   + +    N VHRDL A N+L+++NL  K++DFG S
Sbjct: 709 SFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLS 768

Query: 139 NLFTPGQLLKTWC----GSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPF 191
                     T+     G  P  + APE  + +++     D+WS G+V++ V+  G  P+
Sbjct: 769 RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPY 827

Query: 192 DGSTLQNLRARVLSGKFRIP 211
              T Q++    +   +R+P
Sbjct: 828 WDMTNQDV-INAIEQDYRLP 846



>gi|56405328|sp|P29597|TYK2_HUMAN   Non-receptor tyrosine-protein kinase TYK2
          Length = 1187

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 57/177 (32%), Positives = 89/177 (50%), Gaps = 11/177 (6%)

Query: 16   TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIYLVTEYA 73
            T ++VA+K + K     ++     +E+ I++ L H HII+     E   E+ + LV EY 
Sbjct: 923  TGEMVAVKAL-KADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYV 981

Query: 74   SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
              G + D+L  H  +   +     +QI   + + H ++ +HRDL A N+LLD +  +KI 
Sbjct: 982  PLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIG 1040

Query: 134  DFGFSNLFTPGQ---LLKTWCGSPPY-AAPE-LFEGKEYDGPKVDIWSLGVVLYVLV 185
            DFG +     G     ++    SP +  APE L E K Y     D+WS GV LY L+
Sbjct: 1041 DFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYAS--DVWSFGVTLYELL 1095



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 61/249 (24%), Positives = 96/249 (38%), Gaps = 32/249 (12%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           V +K++D +  D       +    +M  + H H+  ++ V        +VTEY   G + 
Sbjct: 639 VVLKVLDPSHHDIA--LAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 696

Query: 80  DHLV---AHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136
             L     H  MA K    +  Q+ +A+ +   +N+VH ++   N+LL A L +      
Sbjct: 697 VWLRRERGHVPMAWKMVVAQ--QLASALSYLENKNLVHGNVCGRNILL-ARLGLAEGTSP 753

Query: 137 FSNLFTPGQLLKTWCGSP-----PYAAPELFEGKEYD-GPKVDIWSLGVVLYVLVCGALP 190
           F  L  PG  L            P+ APE   G        +D W  G  L + +C    
Sbjct: 754 FIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATL-LEIC---- 808

Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNK 250
           FDG     L++R  S K    F+     +PE        C  +A    L    L  +P +
Sbjct: 809 FDGEA--PLQSRSPSEKEH--FYQRQHRLPE------PSCPQLAT---LTSQCLTYEPTQ 855

Query: 251 RLSMEQICK 259
           R S   I +
Sbjct: 856 RPSFRTILR 864



>gi|2499596|sp|Q16659|MK06_HUMAN   Mitogen-activated protein kinase 6 (Extracellular signal-regulated
           kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK)
          Length = 721

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 68/286 (23%), Positives = 125/286 (43%), Gaps = 53/286 (18%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETE--------------RM 65
           VAIK I  T  D +++K   RE++I++ L H +I+++++++                   
Sbjct: 46  VAIKKIVLT--DPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNS 103

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 125
           +Y+V EY        +++  G + E+ AR    Q++  + + H  N++HRDLK  NL ++
Sbjct: 104 VYIVQEYMETD--LANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFIN 161

Query: 126 A-NLNIKIADFGFSNLFTPGQ---------LLKTWCGSPPYAAPELFEGKEYDGPKVDIW 175
             +L +KI DFG + +  P           L+  W     Y +P L          +D+W
Sbjct: 162 TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKW-----YRSPRLLLSPNNYTKAIDMW 216

Query: 176 SLGVVLYVLVCGALPFDGS--------TLQNL-------RARVLSGKFRIPFFMSTGLVP 220
           + G +   ++ G   F G+         L+++       R  +LS    IP ++   +  
Sbjct: 217 AAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLS---VIPVYIRNDMT- 272

Query: 221 ELDKRLKAGCLSIA-ECEHLIRHMLVLDPNKRLSMEQICKHKWMKL 265
           E  K L      I+ E    +  +L   P  RL+ E+   H +M +
Sbjct: 273 EPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSI 318



>gi|2497572|sp|Q15375|EPHA7_HUMAN   Ephrin type-A receptor 7 precursor (Tyrosine-protein kinase
           receptor EHK-3) (Eph homology kinase-3) (Receptor
           protein-tyrosine kinase HEK11)
          Length = 998

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 54/198 (27%), Positives = 96/198 (48%), Gaps = 9/198 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + K    E+  +    E  IM    HP+++ L  V+   + + +V E+   G + 
Sbjct: 662 VAIKTL-KVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALD 720

Query: 80  DHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L  H G+    +     + I   + +      VHRDL A N+L+++NL  K++DFG S
Sbjct: 721 AFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLS 780

Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193
            +    P  +  T  G  P  + APE  + +++     D+WS G+V++ V+  G  P+  
Sbjct: 781 RVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPYWD 839

Query: 194 STLQNLRARVLSGKFRIP 211
            + Q++   +  G +R+P
Sbjct: 840 MSNQDVIKAIEEG-YRLP 856



>gi|6685617|sp|Q99683|M3K5_HUMAN   Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase
           kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis
           signal-regulating kinase 1) (ASK-1)
          Length = 1374

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 78/311 (25%), Positives = 133/311 (42%), Gaps = 31/311 (9%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           V I I +  + D    + +  E+ + K L H +I++          I +  E   GG + 
Sbjct: 704 VRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLS 763

Query: 80  DHLVAH-GRMAEKEARRKF--KQIVTAVYFCHCRNIVHRDLKAENLLLDANLNI-KIADF 135
             L +  G + + E    F  KQI+  + + H   IVHRD+K +N+L++    + KI+DF
Sbjct: 764 ALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDF 823

Query: 136 GFS-NLFTPGQLLKTWCGSPPYAAPELFE-GKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
           G S  L       +T+ G+  Y APE+ + G    G   DIWSLG  +  +  G  PF  
Sbjct: 824 GTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF-- 881

Query: 194 STLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVLDPNKRLS 253
             L   +A +    F++  F    + PE+ + +       AE +  I      DP+KR  
Sbjct: 882 YELGEPQAAM----FKVGMFK---VHPEIPESMS------AEAKAFILKCFEPDPDKRAC 928

Query: 254 MEQICKHKWMKLGD----ADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQ- 308
              +   +++K+        P    L A   +      +  ++  V + +ED     E  
Sbjct: 929 ANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE-----YLRSISLPVPVLVEDTSSSSEYG 983

Query: 309 TLQPDGTLNLD 319
           ++ PD  L +D
Sbjct: 984 SVSPDTELKVD 994



>gi|47117832|sp|P21709|EPHA1_HUMAN   Ephrin type-A receptor 1 precursor (Tyrosine-protein kinase
           receptor EPH)
          Length = 976

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 51/177 (28%), Positives = 85/177 (48%), Gaps = 7/177 (3%)

Query: 40  REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL-VAHGRMAEKEARRKFK 98
           RE  IM    HPHI+ L  V+   + I ++TE+   G +   L     ++   +     +
Sbjct: 672 REATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQ 731

Query: 99  QIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTP-GQLLKTWCGSPP-- 155
            I + + +    N VHRDL A N+L++ NL  K++DFG + L        +T  G  P  
Sbjct: 732 GIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIR 791

Query: 156 YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRIP 211
           + APE    + +     D+WS G+V++ VL  G  P+   + Q +   +  G +R+P
Sbjct: 792 WTAPEAIAHRIFTTAS-DVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDG-YRLP 846



>gi|12643404|sp|O60674|JAK2_HUMAN   Tyrosine-protein kinase JAK2 (Janus kinase 2) (JAK-2)
          Length = 1132

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 23/188 (12%)

Query: 11   DFLQE-TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET--ERMIY 67
            D LQ+ T ++VA+K +  +   EE+L+   RE++I+K L H +I++   V  +   R + 
Sbjct: 869  DPLQDNTGEVVAVKKLQHST--EEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLK 926

Query: 68   LVTEYASGGEIFDHLVAHG-RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA 126
            L+ EY   G + D+L  H  R+   +  +   QI   + +   +  +HRDL   N+L++ 
Sbjct: 927  LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN 986

Query: 127  NLNIKIADFGFSNLF----------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176
               +KI DFG + +            PG+    W     YA   L E K       D+WS
Sbjct: 987  ENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW-----YAPESLTESK--FSVASDVWS 1039

Query: 177  LGVVLYVL 184
             GVVLY L
Sbjct: 1040 FGVVLYEL 1047



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 44/188 (23%), Positives = 79/188 (42%), Gaps = 14/188 (7%)

Query: 9   IQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYL 68
           + D+ Q  +  V +K++DK   +    +  F    +M  L H H++  Y V        L
Sbjct: 567 VGDYGQLHETEVLLKVLDKAHRNYS--ESFFEAASMMSKLSHKHLVLNYGVCVCGDENIL 624

Query: 69  VTEYASGGEIFDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLLDAN 127
           V E+   G +  +L  +        + +  KQ+  A++F     ++H ++ A+N+LL   
Sbjct: 625 VQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIRE 684

Query: 128 LN--------IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGV 179
            +        IK++D G S    P  +L+      P+  PE  E  +      D WS G 
Sbjct: 685 EDRKTGNPPFIKLSDPGISITVLPKDILQE---RIPWVPPECIENPKNLNLATDKWSFGT 741

Query: 180 VLYVLVCG 187
            L+ +  G
Sbjct: 742 TLWEICSG 749



>gi|125333|sp|P29317|EPHA2_HUMAN   Ephrin type-A receptor 2 precursor (Tyrosine-protein kinase
           receptor ECK) (Epithelial cell kinase)
          Length = 976

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 57/198 (28%), Positives = 92/198 (46%), Gaps = 9/198 (4%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF 79
           VAIK + K    E+       E  IM    H +IIRL  V+   + + ++TEY   G + 
Sbjct: 643 VAIKTL-KAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALD 701

Query: 80  DHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFS 138
             L    G  +  +     + I   + +    N VHRDL A N+L+++NL  K++DFG S
Sbjct: 702 KFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLS 761

Query: 139 NLF--TPGQLLKTWCGSPP--YAAPELFEGKEYDGPKVDIWSLGVVLY-VLVCGALPFDG 193
            +    P     T  G  P  + APE    +++     D+WS G+V++ V+  G  P+  
Sbjct: 762 RVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSAS-DVWSFGIVMWEVMTYGERPYWE 820

Query: 194 STLQNLRARVLSGKFRIP 211
            +   +   +  G FR+P
Sbjct: 821 LSNHEVMKAINDG-FRLP 837



>gi|52783149|sp|Q9NRM7|LATS2_HUMAN   Serine/threonine protein kinase LATS2 (Large tumor suppressor
           homolog 2) (Serine/threonine kinase kpm) (Kinase
           phosphorylated during mitosis protein) (Warts-like
           kinase)
          Length = 1088

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 62/267 (23%), Positives = 105/267 (39%), Gaps = 50/267 (18%)

Query: 15  ETKQLVAIKIIDKTQ-LDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           +T  L A+K + K   L+   +  +  E  I+    +  +++LY   + +  +Y V +Y 
Sbjct: 689 DTHALYAMKTLRKKDVLNRNQVVHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYI 748

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
            GG++   L+      E  AR    ++  A+   H    +HRD+K +N+L+D + +IK+ 
Sbjct: 749 PGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLT 808

Query: 134 DFGFSNLF--------------------------------TPGQLLKT------------ 149
           DFG    F                                  G  LKT            
Sbjct: 809 DFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRC 868

Query: 150 ----WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLS 205
                 G+P Y APE+   K Y     D WS+GV+L+ ++ G  PF   T    + +V++
Sbjct: 869 LAHSLVGTPNYIAPEVLLRKGYT-QLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVIN 927

Query: 206 GKFRIPFFMSTGLVPELDKRLKAGCLS 232
            +  +       L PE    +   C S
Sbjct: 928 WENTLHIPAQVKLSPEARDLITKLCCS 954



>gi|2499660|sp|Q15569|TESK1_HUMAN   Dual-specificity testis-specific protein kinase 1 (Testicular
           protein kinase 1)
          Length = 626

 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 49/188 (26%), Positives = 89/188 (47%), Gaps = 10/188 (5%)

Query: 6   GYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERM 65
           G+  + +    +Q   + ++   +L   N     REVQ+M  L HP+I+R   V   +  
Sbjct: 66  GFFSEVYKVRHRQSGQVMVLKMNKLPS-NRGNTLREVQLMNRLRHPNILRFMGVCVHQGQ 124

Query: 66  IYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL- 124
           ++ +TEY +GG +   L +   ++          I   + + H + + HRDL ++N L+ 
Sbjct: 125 LHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVR 184

Query: 125 --DANLNIKIADFGFSN---LFTPGQLLKTWC--GSPPYAAPELFEGKEYDGPKVDIWSL 177
             D      + DFG +    ++  G   +     GSP + APE+  G+ YD  K D+++ 
Sbjct: 185 REDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYD-EKADVFAF 243

Query: 178 GVVLYVLV 185
           G+VL  L+
Sbjct: 244 GIVLCELI 251



>gi|6831583|sp|O14733|MP2K7_HUMAN   Dual specificity mitogen-activated protein kinase kinase 7 (MAP
           kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK
           activating kinase 2) (c-Jun N-terminal kinase kinase 2)
           (JNK kinase 2) (JNKK 2)
          Length = 419

 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 58/258 (22%), Positives = 110/258 (42%), Gaps = 23/258 (8%)

Query: 14  QETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYA 73
           ++T  ++A+K + ++   EEN + +     ++K    P+I++ +    T   +++  E  
Sbjct: 140 RKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM 199

Query: 74  SGGEIFDHLVAH--GRMAEKEARRKFKQIVTAVYFCHCRN-IVHRDLKAENLLLDANLNI 130
             G   + L     G + E+   +    IV A+Y+   ++ ++HRD+K  N+LLD    I
Sbjct: 200 --GTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI 257

Query: 131 KIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGP----KVDIWSLGVVLYVLVC 186
           K+ DFG S      +      G   Y APE  +  +   P    + D+WSLG+ L  L  
Sbjct: 258 KLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT 317

Query: 187 GALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPELDKRLKAGCLSIAECEHLIRHMLVL 246
           G  P+                 +  F + T ++ E    L        + +  ++  L  
Sbjct: 318 GQFPYKNC--------------KTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTK 363

Query: 247 DPNKRLSMEQICKHKWMK 264
           D  KR    ++ +H ++K
Sbjct: 364 DHRKRPKYNKLLEHSFIK 381



>gi|1168867|sp|P11802|CDK4_HUMAN   Cell division protein kinase 4 (Cyclin-dependent kinase 4) (PSK-J3)
          Length = 303

 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 69/259 (26%), Positives = 112/259 (43%), Gaps = 39/259 (15%)

Query: 40  REVQIMKMLC---HPHIIRLYQVMETERM-----IYLVTEYASGG--EIFDHLVAHGRMA 89
           REV +++ L    HP+++RL  V  T R      + LV E+         D     G  A
Sbjct: 55  REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114

Query: 90  EKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKT 149
           E   +   +Q +  + F H   IVHRDLK EN+L+ +   +K+ADFG + +++    L  
Sbjct: 115 ET-IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP 173

Query: 150 WCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFR 209
              +  Y APE+     Y  P VD+WS+G +   +      F G++  +   ++      
Sbjct: 174 VVVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI------ 226

Query: 210 IPFFMSTGLVPE----LDKRLKAGCLS----------IAECE----HLIRHMLVLDPNKR 251
              F   GL PE     D  L  G             + E E     L+  ML  +P+KR
Sbjct: 227 ---FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283

Query: 252 LSMEQICKHKWMKLGDADP 270
           +S  +  +H ++   + +P
Sbjct: 284 ISAFRALQHSYLHKDEGNP 302



>gi|46577085|sp|Q8WXR4|MYO3B_HUMAN   Myosin IIIB
          Length = 1341

 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 74/264 (28%), Positives = 119/264 (45%), Gaps = 39/264 (14%)

Query: 19  LVAIKIIDK-TQLDEENLKKIFREVQIMKMLC-HPHIIRLYQVMETER-----MIYLVTE 71
           L A+KI+D  + +DEE    I  E  I++ L  HP++++ Y +           ++LV E
Sbjct: 52  LAAVKILDPVSDMDEE----IEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLE 107

Query: 72  YASGGEIFDHLVAHGRMAEKEARRKFKQIV----TAVYFCHCRNIVHRDLKAENLLLDAN 127
             +GG + + +    R  ++        I+      +   H   I+HRD+K  N+LL   
Sbjct: 108 LCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTE 167

Query: 128 LNIKIADFGFSNLFTPGQLLK-TWCGSPPYAAPELFE-GKEYDG---PKVDIWSLGVVLY 182
             +K+ DFG S   T  +L + T  G+P + APE+    ++YD     + D+WSLG+   
Sbjct: 168 GGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAI 227

Query: 183 VLVCGALP-FDGSTLQNLRARVLSGKFRIPFF-MSTGLVPELDKRLKAGCLSIAECEHLI 240
            L  G  P FD   ++ L        F+IP     T L PE        C    E  H I
Sbjct: 228 ELGDGDPPLFDMHPVKTL--------FKIPRNPPPTLLHPE------KWC---EEFNHFI 270

Query: 241 RHMLVLDPNKRLSMEQICKHKWMK 264
              L+ D  +R S+  +  H ++K
Sbjct: 271 SQCLIKDFERRPSVTHLLDHPFIK 294



>gi|6685642|sp|O15264|MK13_HUMAN   Mitogen-activated protein kinase 13 (Stress-activated protein
           kinase-4) (Mitogen-activated protein kinase p38 delta)
           (MAP kinase p38 delta)
          Length = 365

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 65/271 (23%), Positives = 116/271 (42%), Gaps = 38/271 (14%)

Query: 20  VAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMI------YLVTEYA 73
           VAIK + +    E   K+ +RE+ ++K + H ++I L  V      +      YLV  + 
Sbjct: 51  VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM 110

Query: 74  SGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIA 133
                    +     +E++ +    Q++  + + H   +VHRDLK  NL ++ +  +KI 
Sbjct: 111 QTDL---QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKIL 167

Query: 134 DFGF---SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 190
           DFG    ++    G ++  W     Y APE+     +    VDIWS+G ++  ++ G   
Sbjct: 168 DFGLARHADAEMTGYVVTRW-----YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTL 222

Query: 191 FDGSTLQNLRARVLSGKFRIPFFMSTGLVPEL-DKRLKAGCLSI---------------- 233
           F G    +   ++L    ++     T  V +L DK  K+   S+                
Sbjct: 223 FKGKDYLDQLTQIL----KVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRAS 278

Query: 234 AECEHLIRHMLVLDPNKRLSMEQICKHKWMK 264
            +   L+  ML LD +KRL+  Q   H + +
Sbjct: 279 PQAADLLEKMLELDVDKRLTAAQALTHPFFE 309



>gi|60393639|sp|Q13546|RIPK1_HUMAN   Receptor-interacting serine/threonine-protein kinase 2
           (Serine/threonine-protein kinase RIP) (Cell death
           protein RIP) (Receptor interacting protein)
          Length = 671

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 51/194 (26%), Positives = 89/194 (45%), Gaps = 15/194 (7%)

Query: 16  TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           T+ L+ +K + K     E+ + +  E ++M  L H  +++L  V+  E    LV EY   
Sbjct: 38  TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEK 97

Query: 76  GEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADF 135
           G +   L A          R   +I+  + + H + ++H+DLK EN+L+D + +IKIAD 
Sbjct: 98  GNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADL 157

Query: 136 GFSNLFTPGQL--------------LKTWCGSPPYAAPE-LFEGKEYDGPKVDIWSLGVV 180
           G ++     +L               K   G+  Y APE L +       K D++S  VV
Sbjct: 158 GLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVV 217

Query: 181 LYVLVCGALPFDGS 194
           L+ +     P++ +
Sbjct: 218 LWAIFANKEPYENA 231



>gi|1708164|sp|P54753|EPHB3_HUMAN   Ephrin type-B receptor 3 precursor (Tyrosine-protein kinase
           receptor HEK-2)
          Length = 998

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 13/218 (5%)

Query: 2   QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME 61
           +V +G + Q   +E    VAIK + K    E   +    E  IM    HP+IIRL  V+ 
Sbjct: 646 EVCRGRLKQPGRREV--FVAIKTL-KVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVT 702

Query: 62  TERMIYLVTEYASGGEIFDHL-VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAE 120
             R + ++TE+     +   L +  G+    +     + I   + +    N VHRDL A 
Sbjct: 703 KSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAAR 762

Query: 121 NLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS------PPYAAPELFEGKEYDGPKVDI 174
           N+L+++NL  K++DFG S          T+  S        + APE    +++     D+
Sbjct: 763 NILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSAS-DV 821

Query: 175 WSLGVVLY-VLVCGALPFDGSTLQNLRARVLSGKFRIP 211
           WS G+V++ V+  G  P+   + Q++    +   +R+P
Sbjct: 822 WSYGIVMWEVMSYGERPYWDMSNQDV-INAVEQDYRLP 858



>gi|24211444|sp|Q96Q40|AL2S7_HUMAN   Serine/threonine-protein kinase ALS2CR7 (Amyotrophic lateral
           sclerosis 2 chromosomal region candidate gene protein 7)
          Length = 384

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 48/178 (26%), Positives = 86/178 (48%), Gaps = 4/178 (2%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGE 77
           QLVA+K+I     +      I RE  ++K L H +I+ L+ ++ T+  +  V EY    +
Sbjct: 76  QLVALKVISMNAEEGVPFTAI-REASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHT-D 133

Query: 78  IFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFG 136
           +  ++  H G +     R    Q++  + + H ++++HRDLK +NLL+     +K+ADFG
Sbjct: 134 LAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFG 193

Query: 137 FSNLFT-PGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDG 193
            +   + P Q   +   +  Y  P+   G      ++DIW  G +   +  G   F G
Sbjct: 194 LARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPG 251



>gi|1174527|sp|P43405|KSYK_HUMAN   Tyrosine-protein kinase SYK (Spleen tyrosine kinase)
          Length = 635

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 57/212 (26%), Positives = 95/212 (44%), Gaps = 14/212 (6%)

Query: 3   VVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMET 62
           V KGY     +++  + VA+KI+     D     ++  E  +M+ L +P+I+R+  + E 
Sbjct: 385 VKKGYYQ---MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEA 441

Query: 63  ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENL 122
           E  + LV E A  G +  +L  +  + +K       Q+   + +    N VHRDL A N+
Sbjct: 442 ESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNV 500

Query: 123 LLDANLNIKIADFGFSNL------FTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWS 176
           LL      KI+DFG S        +   Q    W     + APE     ++   K D+WS
Sbjct: 501 LLVTQHYAKISDFGLSKALRADENYYKAQTHGKW--PVKWYAPECINYYKFSS-KSDVWS 557

Query: 177 LGVVLY-VLVCGALPFDGSTLQNLRARVLSGK 207
            GV+++     G  P+ G     + A +  G+
Sbjct: 558 FGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589



>gi|50403745|sp|P52333|JAK3_HUMAN   Tyrosine-protein kinase JAK3 (Janus kinase 3) (JAK-3) (Leukocyte
            janus kinase) (L-JAK)
          Length = 1124

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 22/182 (12%)

Query: 16   TKQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYA 73
            T  LVA+K +  +  D++  +   RE+QI+K L    I++   V      + + LV EY 
Sbjct: 848  TGALVAVKQLQHSGPDQQ--RDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYL 905

Query: 74   SGGEIFDHLVAH-GRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKI 132
              G + D L  H  R+          QI   + +   R  VHRDL A N+L+++  ++KI
Sbjct: 906  PSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKI 965

Query: 133  ADFGFSNLF----------TPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLY 182
            ADFG + L            PGQ    W  +P   +  +F  +       D+WS GVVLY
Sbjct: 966  ADFGLAKLLPLDKDYYVVREPGQSPIFWY-APESLSDNIFSRQS------DVWSFGVVLY 1018

Query: 183  VL 184
             L
Sbjct: 1019 EL 1020



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 38/179 (21%), Positives = 74/179 (41%), Gaps = 15/179 (8%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREV-QIMKMLCHPHIIRLYQVMETERMIYLVTEYASG 75
           K  V +K++D      +N  + F E   +M  + + H++ L+ V        +V E+   
Sbjct: 550 KTEVLLKVMDAKH---KNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDST-MVQEFVHL 605

Query: 76  GEIFDHLVAHGRMAEKEARRKF-KQIVTAVYFCHCRNIVHRDLKAENLLL------DANL 128
           G I  +L   G +     + +  KQ+  A+ +   + + H ++ A  +LL       +  
Sbjct: 606 GAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPP 665

Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG 187
            IK++D G S      ++L       P+ APE     +    + D W  G  ++ +  G
Sbjct: 666 FIKLSDPGVSPAVLSLEMLTDRI---PWVAPECLREAQTLSLEADKWGFGATVWEVFSG 721



>gi|1170596|sp|P45985|MP2K4_HUMAN   Dual specificity mitogen-activated protein kinase kinase 4 (MAP
           kinase kinase 4) (JNK activating kinase 1) (c-Jun
           N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1)
           (SEK1)
          Length = 399

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 53/186 (28%), Positives = 87/186 (46%), Gaps = 16/186 (8%)

Query: 18  QLVAIKIIDKTQLDEENLKKIFREVQI-MKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           Q++A+K I  T +DE+  K++  ++ + M+    P+I++ Y  +  E   ++  E  S  
Sbjct: 126 QIMAVKRIRST-VDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS 184

Query: 77  EIFDHLVAH-----GRMAEKEARRKFKQIVTAVYFCHCRN---IVHRDLKAENLLLDANL 128
             FD    +       +  +E   K   + T     H +    I+HRD+K  N+LLD + 
Sbjct: 185 --FDKFYKYVYSVLDDVIPEEILGKIT-LATVKALNHLKENLKIIHRDIKPSNILLDRSG 241

Query: 129 NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLV 185
           NIK+ DFG S             G  PY APE  +    ++    + D+WSLG+ LY L 
Sbjct: 242 NIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA 301

Query: 186 CGALPF 191
            G  P+
Sbjct: 302 TGRFPY 307



>gi|1345718|sp|P49336|CDK8_HUMAN   Cell division protein kinase 8 (Protein kinase K35)
          Length = 464

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 72/292 (24%), Positives = 120/292 (41%), Gaps = 57/292 (19%)

Query: 40  REVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYASGGEIFDHLVAHGRMAEKE----- 92
           RE+ +++ L HP++I L +V     +R ++L+ +YA       H++   R ++       
Sbjct: 65  REIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHD--LWHIIKFHRASKANKKPVQ 122

Query: 93  -----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTP 143
                 +    QI+  +++ H   ++HRDLK  N+L+         +KIAD GF+ LF  
Sbjct: 123 LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF-- 180

Query: 144 GQLLKTWCGSPP------YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPF-----D 192
              LK      P      Y APEL  G  +    +DIW++G +   L+     F     D
Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240

Query: 193 GSTLQNLRARVLSGKFRIPFFMS-------------TGLVPELDKRLKAGCLSIAECE-- 237
             T        L   F +  F +             + L+ +  +     C  I   E  
Sbjct: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 300

Query: 238 ---------HLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQ 280
                    HL++ +L +DP KR++ EQ  +  +  L D  P  D + A CQ
Sbjct: 301 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF-LEDPLPTSD-VFAGCQ 350



>gi|60391917|sp|Q9BWU1|CD2L6_HUMAN   Cell division cycle 2-like protein kinase 6 (CDC2-related protein
           kinase 6) (Death-preventing kinase) (Cyclin-dependent
           kinase 11)
          Length = 502

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 74/310 (23%), Positives = 132/310 (42%), Gaps = 67/310 (21%)

Query: 40  REVQIMKMLCHPHIIRLYQVM--ETERMIYLVTEYASGGEIFDHLVAHGRMAEKE----- 92
           RE+ +++ L HP++I L +V    ++R ++L+ +YA       H++   R ++       
Sbjct: 65  REIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHD--LWHIIKFHRASKANKKPMQ 122

Query: 93  -----ARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL----DANLNIKIADFGFSNLFTP 143
                 +    QI+  +++ H   ++HRDLK  N+L+         +KIAD GF+ LF  
Sbjct: 123 LPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF-- 180

Query: 144 GQLLKTWCGSPP------YAAPELFEGKEYDGPKVDIWSLGVVLYVLVCG---------- 187
              LK      P      Y APEL  G  +    +DIW++G +   L+            
Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240

Query: 188 ---ALPFDGSTLQNL-------------------RARVLSGKFRIPFFMSTGLVPELDK- 224
              + PF    L  +                       L   FR   + ++ L+  ++K 
Sbjct: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH 300

Query: 225 RLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKE 284
           ++K      ++   L++ +L +DP KR++ EQ  +  + +  D  P  D + A CQ    
Sbjct: 301 KVKPD----SKVFLLLQKLLTMDPTKRITSEQALQDPYFQ-EDPLPTLD-VFAGCQIPYP 354

Query: 285 ERQVDPLNED 294
           +R+   LNED
Sbjct: 355 KREF--LNED 362



>gi|549081|sp|P35590|TIE1_HUMAN   Tyrosine-protein kinase receptor Tie-1 precursor
          Length = 1138

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 65/229 (28%), Positives = 100/229 (43%), Gaps = 35/229 (15%)

Query: 2    QVVKGYIIQDFLQETKQLVAIKIIDKTQLDEENLKKIFREVQIM-KMLCHPHIIRLYQVM 60
            QV++  I +D L   K   AIK++ K    E + +    E++++ K+  HP+II L    
Sbjct: 852  QVIRAMIKKDGL---KMNAAIKML-KEYASENDHRDFAGELEVLCKLGHHPNIINLLGAC 907

Query: 61   ETERMIYLVTEYASGGEIFDHLVA-------------HGRMAEKEARRKFK---QIVTAV 104
            +    +Y+  EYA  G + D L               HG  +   +R+  +        +
Sbjct: 908  KNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGM 967

Query: 105  YFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN------LFTPGQLLKTWCGSPPYAA 158
             +   +  +HRDL A N+L+  NL  KIADFG S         T G+L   W       A
Sbjct: 968  QYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRW------MA 1021

Query: 159  PELFEGKEYDGPKVDIWSLGVVLYVLV-CGALPFDGSTLQNLRARVLSG 206
             E      Y   K D+WS GV+L+ +V  G  P+ G T   L  ++  G
Sbjct: 1022 IESLNYSVYT-TKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 1069



>gi|32172458|sp|Q9BQI3|E2K1_HUMAN   Eukaryotic translation initiation factor 2 alpha kinase 1
           (Heme-regulated eukaryotic initiation factor eIF-2-alpha
           kinase) (Heme-regulated inhibitor) (Heme-controlled
           repressor) (HCR) (Hemin-sensitive initiation factor-2
           alpha kinase) (PRO1362)
          Length = 630

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 75/264 (28%), Positives = 124/264 (46%), Gaps = 45/264 (17%)

Query: 58  QVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDL 117
           Q+ E     ++V     G E  D       MA   A + F+++V  V++ H   IVHRDL
Sbjct: 385 QLCELSLWDWIVERNKRGREYVDESACPYVMANV-ATKIFQELVEGVFYIHNMGIVHRDL 443

Query: 118 KAENLLLDA-NLNIKIADFGF---------------SNLFTPGQLLKTWCGSPPYAAPEL 161
           K  N+ L   +  +KI DFG                +   TP    +   G+  YA+PE 
Sbjct: 444 KPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRV--GTCLYASPEQ 501

Query: 162 FEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTGLVPE 221
            EG EYD  K D++SLGVVL  L     PF G+ ++  RA VL+G       + TG +PE
Sbjct: 502 LEGSEYDA-KSDMYSLGVVLLELF---QPF-GTEME--RAEVLTG-------LRTGQLPE 547

Query: 222 LDKRLKAGCLSIAECEHLIRHMLVLDPNKRLSMEQICKHK-WMKLGDADPNFDRLIAECQ 280
               L+  C   A+    I+H+   + ++R S  Q+ + + +   G+ +     L  + +
Sbjct: 548 ---SLRKRCPVQAK---YIQHLTRRNSSQRPSAIQLLQSELFQNSGNVN-----LTLQMK 596

Query: 281 QLKEERQVDPLNEDVLLAMEDMGL 304
            +++E+++  L + + L  +D G+
Sbjct: 597 IIEQEKEIAELKKQLNLLSQDKGV 620



>gi|266423|sp|Q00534|CDK6_HUMAN   Cell division protein kinase 6 (Serine/threonine-protein kinase
           PLSTIRE)
          Length = 326

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 53/179 (29%), Positives = 90/179 (50%), Gaps = 14/179 (7%)

Query: 13  LQETKQLVAIKIIDKTQLDEENLK-KIFREVQIMKMLC---HPHIIRLYQVM-----ETE 63
           L+   + VA+K + + Q  EE +     REV +++ L    HP+++RL+ V      + E
Sbjct: 33  LKNGGRFVALKRV-RVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRE 91

Query: 64  RMIYLVTEYASGG--EIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAEN 121
             + LV E+         D +   G   E      F Q++  + F H   +VHRDLK +N
Sbjct: 92  TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF-QLLRGLDFLHSHRVVHRDLKPQN 150

Query: 122 LLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV 180
           +L+ ++  IK+ADFG + +++    L +   +  Y APE+     Y  P VD+WS+G +
Sbjct: 151 ILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATP-VDLWSVGCI 208



>gi|2497562|sp|Q16288|NTRK3_HUMAN   NT-3 growth factor receptor precursor (Neurotrophic tyrosine kinase
           receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC)
           (Trk-C)
          Length = 839

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 57/199 (28%), Positives = 87/199 (43%), Gaps = 36/199 (18%)

Query: 17  KQLVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGG 76
           K LVA+K +    L     K   RE +++  L H HI++ Y V      + +V EY   G
Sbjct: 566 KMLVAVKALKDPTLAAR--KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHG 623

Query: 77  EIFDHLVAHGRMA-------EKEARRKF---------KQIVTAVYFCHCRNIVHRDLKAE 120
           ++   L AHG  A        ++A+ +           QI + + +   ++ VHRDL   
Sbjct: 624 DLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATR 683

Query: 121 NLLLDANLNIKIADFGFS---------NLFTP-GQLLKTWCGSPPYA-------APELFE 163
           N L+ ANL +KI DFG S          LF P G     WC    +         PE   
Sbjct: 684 NCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM 743

Query: 164 GKEYDGPKVDIWSLGVVLY 182
            +++   + D+WS GV+L+
Sbjct: 744 YRKFT-TESDVWSFGVILW 761






  Database: Non-redundant SwissProt sequences
    Posted date:  Mar 15, 2005 10:11 AM
  Number of letters in database: 60,490,055
  Number of sequences in database:  164,271
  
Lambda     K      H
   0.316    0.132    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,941,679
Number of Sequences: 164271
Number of extensions: 145878
Number of successful extensions: 747
Number of sequences better than 10.0: 64
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 531
Number of HSP's gapped (non-prelim): 167
length of query: 1347
length of database: 6,424,444
effective HSP length: 107
effective length of query: 1240
effective length of database: 5,150,609
effective search space: 6386755160
effective search space used: 6386755160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)







 


 
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Show
  Graphical OverviewLinkoutSequence RetrievalNCBI-gi in format


 


 
Use new formatter
  Masking Character
Masking Color



 


 
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  Descriptions
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  with inclusion threshold:


 


 
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Expect value range:
    







 or



		Format

		Show	Graphical OverviewLinkoutSequence RetrievalNCBI-gi in format

		Use new formatter	Masking Character Masking Color

		Number of:	Descriptions Alignments

		Alignment view

		Format for PSI-BLAST	with inclusion threshold:

		Limit results by entrez query	or select from:

		Expect value range: