ORGANISM: Human herpesvirus 8

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

PRODUCT: dUTPase homolog; EBV BLLF3 homolog

GENE: ORF 54

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

CONSERVED DOMAIN: dUTPase; dUTPase hydrolyses dUTP to dUMP and pyrophosphate. Deoxycytidine deaminase

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ORGANISM: Macaca mulatta rhadinovirus

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

PRODUCT: dUTPase

GENE: ORF 54

SCORE: 223 (identity 41%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

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ORGANISM: Equine herpesvirus 2

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae

PRODUCT:deoxyuridine triphosphatase 54

GENE: ORF 54

SCORE: 186 (identity 37%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

PAPER: The DNA sequence of equine herpesvirus 2.Telford EA, Watson MS, Aird HC, Perry J, Davison AJ.J Mol Biol. 1995 Jun 9;249(3):520-8.

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ORGANISM: Saimiriine herpesvirus 2

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

PRODUCT:dUTPase

GENE: ORF 54

SCORE: 177 (identity 34%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

PAPER:Primary structure of the herpesvirus saimiri genome. Albrecht JC, Nicholas J, Biller D, Cameron KR, Biesinger B, Newman C, Wittmann S, Craxton MA, Coleman H, Fleckenstein B, et al.J Virol. 1992 Aug;66(8):5047-58.

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ORGANISM: Ateline herpesvirus 3

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

PRODUCT:hypotetical protein

GENE: ORF 54

SCORE: 176 (identity 33%)

FUNCTION: desconeguda

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ORGANISM: Alcelaphine herpesvirus

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

PRODUCT:dUTPase

GENE: ORF 54

SCORE: 134 (identity 30%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

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ORGANISM: Callitrichine herpesvirus 3

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus

PRODUCT: ORF 48

SCORE: 131 (identity 33%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

PAPER: Complete genomic sequence of an Epstein-Barr virus-related herpesvirus naturally infecting a new world primate: a defining point in the evolution of oncogenic lymphocryptoviruses.Rivailler P, Cho YG, Wang F.J Virol. 2002 Dec;76(23):12055-68.

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ORGANISM: Bovine herpesvirus 4

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae

PRODUCT: dUTPase

GENE: ORF 54

SCORE: 125 (identity 34%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

PAPER: Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication.Zimmermann W, Broll H, Ehlers B, Buhk HJ, Rosenthal A, Goltz M.J Virol. 2001 Feb;75(3):1186-94.

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ORGANISM: Cercopithicine herpesvirus 15

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus; human herpesvirus 4

PRODUCT: dUTPase

NOTE: similar to Epstein-Barr virus BLLF3

SCORE: 122 (identity 32%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

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ORGANISM: Human herpesvirus 4 (Epstein-Barr)

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus

PRODUCT: dUTPase

GENE: BLLF3

SCORE: 120 (identity 32%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

PAPER: DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Seguin C, et al. Nature. 1984 Jul 19-25;310(5974):207-11.

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ORGANISM: Murid herpesvirus 4

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae

PRODUCT: dUTPase

GENE: ORF 54

SCORE: 103 (identity 32%)

FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle

PAPER: Complete sequence and genomic analysis of murine gammaherpesvirus 68.Virgin HW 4th, Latreille P, Wamsley P, Hallsworth K, Weck KE, Dal Canto AJ, Speck SH.J Virol. 1997 Aug;71(8):5894-904.