ORGANISM: Human herpesvirus 8

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

PRODUCT: vIRF-1

GENE: K9

FUNCTION: Activat per RTA (replication and transcription activator) durant la replicació lítica junt amb K8 i ORF 57. vIRF1 (viral interferon factor) interacciona amb GRIM i inhibeix la mort celular produida per interferon provocant tumoracions.

CONSERVED DOMAIN: Interferon Regulatory Factor (IRF); also known as trytophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region.

*****

ORGANISM: Macaca mulatta rhadinovirus

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus

PRODUCT: R10

NAME: similar to Kaposi's sarcoma-associated herpesvirus vIRF K9

SCORE: 99

FUNCTION: similar to Kaposi's sarcoma-associated herpesvirus vIRF K9