ORGANISME: Human herpesvirus 8

LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.

PRODUCT: transcription activator ORF50

GENE: KIE-1

SCORE: 719 (identitat=80%)

FUNCIO: The switch from latent to lytic infection of Kaposi's sarcoma-associated herpesvirus is initiated by the immediate early transcriptional activator protein Rta/open reading frame 50 (ORF50). The Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator protein (RTA) (or ORF50) is thought to be the most critical trigger that upregulates expression of many downstream viral lytic cycle genes.

CONSERVED DOMAINS: pfam03326, Herpes_TAF50, Herpesvirus transcription activation factor (transactivator). This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.

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ORGANISME: Human herpesvirus 8

LINEAGE:Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.

PRODUCT: EBV BRLF1 (R trasactivator) homolog

GENE: ORF 50

SCORE: 717 (identitat=80%)

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ORGANISME: Cercopithecine herpesvirus 17

LINEAGE:Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.

PRODUCT: Immediate-early transcription factor RRta

SCORE: 137 (identitat=43%)

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ORGANISME: Macaca mulatta rhadinovirus

LINEAGE:Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.

PRODUCT: transactivator

SCORE: 134 (identitat=41%)