RID=1079441659-11253-170262430712.BLASTQ3, hg16_dna_2|geneid_v1.1_predicted_protein_2|602

BLASTP 2.2.8 [Jan-05-2004]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.
RID: 1079441659-11253-170262430712.BLASTQ3
Query= hg16_dna_2|geneid_v1.1_predicted_protein_2|602_AA (601 letters)
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,678,069 sequences; 748,330,716 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Taxonomy reports
Distribution of 270 Blast Hits on the Query Sequence

Related Structures

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|32528299|ref|NP_001158.2|  baculoviral IAP repeat-contain...  1038   0.0   
gi|1184320|gb|AAC50373.1|  X-linked inhibitor of apotosis pr...  1036   0.0   
gi|2134780|pir||S69544  apoptosis inhibitor IAP homolog - hu...  1036   0.0   
gi|11560028|ref|NP_071567.1|  baculoviral IAP repeat-contain...   938   0.0   
gi|10765281|gb|AAG22969.1|  inhibitor of apoptosis protein 3...   934   0.0   
gi|11890721|gb|AAG41193.1|  inhibitor of apoptosis protein 3...   931   0.0   
gi|11890719|gb|AAG41192.1|  inhibitor of apoptosis protein 3...   929   0.0   
gi|2497241|sp|Q60989|BIR4_MOUSE  Baculoviral IAP repeat-cont...   924   0.0   
gi|6753088|ref|NP_033818.1|  baculoviral IAP repeat-containi...   905   0.0   
gi|17865297|gb|AAL47170.1|  inhibitor of apoptosis protein 3...   579   e-164 
gi|21759007|sp|Q95M72|BIR8_PANTR  Baculoviral IAP repeat-con...   402   e-111 
gi|44680139|ref|NP_203127.3|  baculoviral IAP repeat-contain...   402   e-110 
gi|21759006|sp|Q95M71|BIR8_GORGO  Baculoviral IAP repeat-con...   401   e-110 
gi|21759009|sp|Q96P09|BIR8_HUMAN  Baculoviral IAP repeat-con...   401   e-110 
gi|35902986|ref|NP_919377.1|  baculoviral IAP repeat-contain...   341   4e-92 
gi|32766697|gb|AAH55246.1|  Birc4 protein [Danio rerio]           338   3e-91 
gi|13786998|pdb|1I4O|C  Chain C, Crystal Structure Of The Xi...   314   4e-84 
gi|27903492|gb|AAO24632.1|  inhibitor of apoptosis protein-1...   294   4e-78 
gi|33414037|gb|AAP04483.1|  inhibitor of apoptosis protein [...   291   4e-77 
gi|37359682|emb|CAE47763.1|  SI:bZ1P14.6.2 (baculoviral IAP ...   291   4e-77 
gi|35902971|ref|NP_919376.1|  baculoviral IAP repeat-contain...   290   8e-77 
gi|2656127|gb|AAB88044.1|  IAP homolog [Gallus gallus]            287   4e-76 
gi|4502141|ref|NP_001157.1|  baculoviral IAP repeat-containi...   283   6e-75 
gi|7512288|pir||S68450  apoptosis inhibitor hiap-2 - human >...   281   4e-74 
gi|25140579|gb|AAN73272.1|  pRb-interacting protein RbBP-36 ...   280   1e-73 
gi|2497239|sp|Q62210|BIR2_MOUSE  Baculoviral IAP repeat-cont...   278   2e-73 
gi|6680698|ref|NP_031491.1|  baculoviral IAP repeat-containi...   278   2e-73 
gi|11120700|ref|NP_068520.1|  apoptosis inhibitor 2 [Rattus ...   278   2e-73 
gi|38541348|gb|AAH62055.1|  Apoptosis inhibitor 2 [Rattus no...   278   3e-73 
gi|10765285|gb|AAG22971.1|  inhibitor of apoptosis protein 2...   276   9e-73 
gi|5669090|gb|AAD46161.1|  API2-MLT fusion protein [Homo sap...   273   1e-71 
gi|7512287|pir||S68449  apoptosis inhibitor hiap-1 - human >...   272   2e-71 
gi|13027446|ref|NP_076477.1|  inhibitor of apoptosis protein...   272   2e-71 
gi|3978244|gb|AAC83232.1|  inhibitor of apoptosis protein-1 ...   271   3e-71 
gi|4502139|ref|NP_001156.1|  baculoviral IAP repeat-containi...   271   3e-71 
gi|18655901|pdb|1KMC|C  Chain C, Crystal Structure Of The Ca...   266   9e-70 
gi|13096729|pdb|1G73|C  Chain C, Crystal Structure Of Smac B...   266   1e-69 
gi|6680696|ref|NP_031490.1|  baculoviral IAP repeat-containi...   264   5e-69 
gi|2497240|sp|Q90660|BIR_CHICK  Inhibitor of apoptosis prote...   263   9e-69 
gi|20150096|pdb|1I51|E  Chain E, Crystal Structure Of Caspas...   263   1e-68 
gi|13096716|pdb|1G3F|A  Chain A, Nmr Structure Of A 9 Residu...   258   3e-67 
gi|13786994|pdb|1I3O|E  Chain E, Crystal Structure Of The Co...   258   3e-67 
gi|15826317|pdb|1F9X|A  Chain A, Average Nmr Solution Struct...   258   3e-67 
gi|10120972|pdb|1C9Q|A  Chain A, Average Nmr Solution Struct...   258   3e-67 
gi|22000680|gb|AAM88215.1|  IAP-like protein [Xenopus laevis]     244   3e-63 
gi|1184314|gb|AAC46988.1|  inhibitor of apoptosis protein         236   9e-61 
gi|11991646|gb|AAG42316.1|  apoptosis inhibitor ch-IAP1 [Gal...   235   2e-60 
gi|1160518|gb|AAC41610.1|  apoptosis 2 inhibitor >gi|1586950...   235   2e-60 
gi|15030166|gb|AAH11338.1|  Birc2 protein [Mus musculus]          235   2e-60 
gi|2497244|sp|Q24307|IAP2_DROME  Apoptosis 2 inhibitor (Inhi...   234   4e-60 
gi|17137140|ref|NP_477127.1|  Inhibitor of apoptosis 2 CG829...   234   4e-60 
gi|3914339|sp|O62640|PIAP_PIG  Putative inhibitor of apoptos...   232   2e-59 
gi|2133636|pir||S69545  apoptosis inhibitor IAP homolog - fr...   232   2e-59 
gi|7447801|pir||S68452  apoptosis inhibitor diap - fruit fly...   229   2e-58 
gi|1145606|gb|AAB08398.1|  DIHA                                   226   9e-58 
gi|29726782|pdb|1NW9|A  Chain A, Structure Of Caspase-9 In A...   221   3e-56 
gi|18251959|gb|AAL66179.1|  X-linked inhibitor of apoptosis ...   215   2e-54 
gi|15042062|gb|AAK81891.1|  IAP-like protein 3 [Homo sapiens]     213   1e-53 
gi|7021390|gb|AAF35320.1|  inhibitor of apoptosis 1 [Gallus ...   189   2e-46 
gi|7021388|gb|AAF35319.1|  inhibitor of apoptosis 1 [Gallus ...   189   2e-46 
gi|26245347|gb|AAN60208.1|  neuronal apoptosis inhibitory pr...   167   9e-40 
gi|26050066|gb|AAN77912.1|  BIRC1E protein [Mus musculus]         166   2e-39 
gi|26023795|gb|AAN77612.1|  baculoviral IAP repeat-containin...   166   2e-39 
gi|26245353|gb|AAN60211.1|  neuronal apoptosis inhibitory pr...   166   2e-39 
gi|9055286|ref|NP_035000.1|  baculoviral IAP repeat-containi...   166   2e-39 
gi|26023803|gb|AAN77616.1|  neuronal apoptosis inhibitory pr...   166   2e-39 
gi|5932014|gb|AAD56765.1|  neuronal apoptosis inhibitory pro...   165   3e-39 
gi|27902277|ref|NP_035001.1|  baculoviral IAP repeat-contain...   164   8e-39 
gi|7021325|gb|AAF35285.1|  inhibitor of apoptosis protein [S...   164   8e-39 
gi|5932004|gb|AAD56760.1|  neuronal apoptosis inhibitory pro...   163   1e-38 
gi|26245343|gb|AAN60206.1|  neuronal apoptosis inhibitory pr...   163   1e-38 
gi|12643317|sp|Q9R016|BIRE_MOUSE  Baculoviral IAP repeat-con...   163   1e-38 
gi|12585188|sp|Q9JIB3|BIRG_MOUSE  Baculoviral IAP repeat-con...   163   1e-38 
gi|26023804|gb|AAN77617.1|  neuronal apoptosis inhibitory pr...   162   3e-38 
gi|12643314|sp|Q9JIB6|BIRF_MOUSE  Baculoviral IAP repeat-con...   162   3e-38 
gi|34853608|ref|XP_226743.2|  similar to neuronal apoptosis ...   161   3e-38 
gi|3445577|gb|AAC32497.1|  inhibitor of apoptosis protein [R...   159   1e-37 
gi|34853492|ref|XP_226742.2|  baculoviral IAP repeat-contain...   159   2e-37 
gi|12643316|sp|Q9QWK5|BIRA_MOUSE  Baculoviral IAP repeat-con...   154   6e-36 
gi|9082151|gb|AAF82752.1|  neuronal apoptosis inhibitory pro...   154   7e-36 
gi|6679008|ref|NP_032696.1|  baculoviral IAP repeat-containi...   154   7e-36 
gi|5932010|gb|AAD56763.1|  neuronal apoptosis inhibitory pro...   152   2e-35 
gi|26245337|gb|AAN77587.1|  neuronal apoptosis inhibitory pr...   150   7e-35 
gi|26245335|gb|AAN77586.1|  neuronal apoptosis inhibitory pr...   150   7e-35 
gi|5932003|gb|AAD56759.1|  neuronal apoptosis inhibitory pro...   150   7e-35 
gi|26245331|gb|AAN77584.1|  neuronal apoptosis inhibitory pr...   150   7e-35 
gi|26245339|gb|AAN77588.1|  neuronal apoptosis inhibitory pr...   150   7e-35 
gi|26050064|gb|AAN77911.1|  BIRC1B protein [Mus musculus]         150   7e-35 
gi|26245333|gb|AAN77585.1|  neuronal apoptosis inhibitory pr...   150   7e-35 
gi|6754790|ref|NP_035002.1|  baculoviral IAP repeat-containi...   150   7e-35 
gi|26023802|gb|AAN77615.1|  neuronal apoptosis inhibitory pr...   150   7e-35 
gi|26023796|gb|AAN77613.1|  baculoviral IAP repeat-containin...   150   1e-34 
gi|14248546|gb|AAK57560.1|  inhibitor of apoptosis protein [...   145   2e-33 
gi|9629973|ref|NP_046191.1|  inhibitor of apoptosis protein ...   145   2e-33 
gi|24286571|gb|AAN46650.1|  inhibitor of apoptosis protein [...   145   3e-33 
gi|4758752|ref|NP_004527.1|  baculoviral IAP repeat-containi...   144   6e-33 
gi|2135814|pir||A55478  neuronal apoptosis inhibitory protei...   144   8e-33 
gi|9964335|ref|NP_064803.1|  inhibitor of apoptosis protein ...   140   8e-32 
gi|6635437|gb|AAF19819.1|  inhibitor of apoptosis protein [T...   140   8e-32 
gi|27923008|dbj|BAC55952.1|  HcIAP-3 [Hyphantria cunea nucle...   140   9e-32 

Alignments


>gi|32528299|ref|NP_001158.2|   baculoviral IAP repeat-containing protein 4; X-linked inhibitor of
           apoptosis; apoptosis inhibitor 3 [Homo sapiens]
 gi|12643387|sp|P98170|BIR4_HUMAN   Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis
           protein 3) (X-linked inhibitor of apoptosis protein)
           (X-linked IAP) (IAP-like protein) (HILP)
 gi|8744934|emb|CAB95312.1|   dJ315G1.2 (apoptosis inhibitor 3 (XIAP, HILP)) [Homo sapiens]
 gi|21619764|gb|AAH32729.1|   Baculoviral IAP repeat-containing protein 4 [Homo sapiens]
          Length = 497

 Score = 1038 bits (2685), Expect = 0.0
 Identities = 487/497 (97%), Positives = 487/497 (97%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
Sbjct: 61  VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
Sbjct: 121 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
Sbjct: 181 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 300

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
Sbjct: 301 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 360

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
Sbjct: 361 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 420

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           SMQDESSQTSLQKEIST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 421 SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 480

Query: 585 CPMCYTVITFKQKIFMS 601
           CPMCYTVITFKQKIFMS
Sbjct: 481 CPMCYTVITFKQKIFMS 497



>gi|1184320|gb|AAC50373.1|   X-linked inhibitor of apotosis protein
          Length = 497

 Score = 1036 bits (2680), Expect = 0.0
 Identities = 486/497 (97%), Positives = 486/497 (97%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
Sbjct: 61  VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMY EEARLKSFQNWPDYAHLT
Sbjct: 121 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYCEEARLKSFQNWPDYAHLT 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
Sbjct: 181 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 300

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
Sbjct: 301 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 360

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
Sbjct: 361 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 420

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           SMQDESSQTSLQKEIST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 421 SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 480

Query: 585 CPMCYTVITFKQKIFMS 601
           CPMCYTVITFKQKIFMS
Sbjct: 481 CPMCYTVITFKQKIFMS 497



>gi|2134780|pir||S69544   apoptosis inhibitor IAP homolog - human
 gi|1016688|gb|AAC50518.1|   IAP-like protein ILP
          Length = 497

 Score = 1036 bits (2678), Expect = 0.0
 Identities = 486/497 (97%), Positives = 486/497 (97%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
Sbjct: 61  VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
Sbjct: 121 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
Sbjct: 181 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 300

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
Sbjct: 301 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 360

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
Sbjct: 361 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 420

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           SM DESSQTSLQKEIST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 421 SMPDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 480

Query: 585 CPMCYTVITFKQKIFMS 601
           CPMCYTVITFKQKIFMS
Sbjct: 481 CPMCYTVITFKQKIFMS 497



>gi|11560028|ref|NP_071567.1|   baculoviral IAP repeat-containing 4; apoptosis inhibitor protein 3
           [Rattus norvegicus]
 gi|12585185|sp|Q9R0I6|BIR4_RAT   Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis
           protein 3) (X-linked inhibitor of apoptosis protein)
           (X-linked IAP) (IAP homolog A) (RIAP3) (RIAP-3)
 gi|6045148|dbj|BAA85304.1|   RIAP3 [Rattus norvegicus]
          Length = 496

 Score =  938 bits (2425), Expect = 0.0
 Identities = 436/497 (87%), Positives = 465/497 (93%), Gaps = 1/497 (0%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEGS+T VPAD NK+EEFVEEFNRLKTFANFPS SPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGSRTVVPADTNKDEEFVEEFNRLKTFANFPSSSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           V+CFSCHAAVDRWQYGDSAVGRHR++SPNCRFINGFY EN ATQST+ GIQNGQYK EN 
Sbjct: 61  VQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGATQSTSPGIQNGQYKSENC 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           +G+R+HFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM SEEARLK+FQNWPDYAHL+
Sbjct: 121 VGNRNHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMCSEEARLKTFQNWPDYAHLS 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTGI DQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRN+N+RSE
Sbjct: 181 PRELASAGLYYTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVNVRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           S  VSSDRNFPNSTN PRNP+MA+Y+ARI TFGTW+YSVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 S-GVSSDRNFPNSTNSPRNPAMAEYDARIVTFGTWLYSVNKEQLARAGFYALGEGDKVKC 299

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLL++KGQEYINNIHLTHSL E +VRT EKTP
Sbjct: 300 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLGESVVRTAEKTP 359

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           S+T++IDDTIFQNPMVQEAIRMGF+FKDIKK MEEK+Q SGSNY SLEVL+ADLV+AQKD
Sbjct: 360 SVTKKIDDTIFQNPMVQEAIRMGFNFKDIKKTMEEKLQTSGSNYLSLEVLIADLVSAQKD 419

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           + QDESSQTSLQK+IST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 420 NSQDESSQTSLQKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 479

Query: 585 CPMCYTVITFKQKIFMS 601
           CPMC TVITFKQKIFMS
Sbjct: 480 CPMCCTVITFKQKIFMS 496



>gi|10765281|gb|AAG22969.1|   inhibitor of apoptosis protein 3 [Rattus norvegicus]
          Length = 496

 Score =  934 bits (2414), Expect = 0.0
 Identities = 434/496 (87%), Positives = 463/496 (93%), Gaps = 1/496 (0%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEGS+T VPAD NK+EEFVEEFNRLKTFANFPS SPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGSRTVVPADTNKDEEFVEEFNRLKTFANFPSSSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           V+CFSCHAAVDRWQYGDSAVGRHR++SPNCRFINGFY EN ATQST+ GIQNGQYK EN 
Sbjct: 61  VQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGATQSTSPGIQNGQYKSENC 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           +G+R+HFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM SEEAR K+FQNWPDYAHL+
Sbjct: 121 VGNRNHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMCSEEARPKTFQNWPDYAHLS 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTGI DQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRN+N+RSE
Sbjct: 181 PRELASAGLYYTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVNVRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           S  VSSDRNFPNSTN PRNP+MA+Y+ARI TFGTW+YSVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 S-GVSSDRNFPNSTNSPRNPAMAEYDARIVTFGTWLYSVNKEQLARAGFYALGEGDKVKC 299

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLL++KGQEYINNIHLTHSL E +VRT EKTP
Sbjct: 300 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLGESVVRTAEKTP 359

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           S+T++IDDTIFQNPMVQEAIRMGF+FKDIKK MEEK+Q SGSNY SLEVL+ADLV+AQKD
Sbjct: 360 SVTKKIDDTIFQNPMVQEAIRMGFNFKDIKKTMEEKLQTSGSNYLSLEVLIADLVSAQKD 419

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           + QDESSQTSLQK+IST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 420 NSQDESSQTSLQKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 479

Query: 585 CPMCYTVITFKQKIFM 600
           CPMC TVITFKQKIFM
Sbjct: 480 CPMCCTVITFKQKIFM 495



>gi|11890721|gb|AAG41193.1|   inhibitor of apoptosis protein 3 [Rattus norvegicus]
          Length = 501

 Score =  931 bits (2405), Expect = 0.0
 Identities = 432/495 (87%), Positives = 461/495 (93%), Gaps = 1/495 (0%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEGS+T VPAD NK+EEFVEEFNRLKTFANFPS SPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGSRTVVPADTNKDEEFVEEFNRLKTFANFPSSSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           V+CFSCHAAVDRWQYGDSAVGRHR++SPNCRFINGFY EN ATQST+ GIQNGQYK EN 
Sbjct: 61  VQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGATQSTSPGIQNGQYKSENC 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           +G+R+HFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM SEEARLK+FQNWPDYAHL+
Sbjct: 121 VGNRNHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMCSEEARLKTFQNWPDYAHLS 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTGI DQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRN+N+RSE
Sbjct: 181 PRELASAGLYYTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVNVRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           S  VSSDRNFPNSTN PRNP+MA+Y+ARI TFGTW+YSVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 S-GVSSDRNFPNSTNSPRNPAMAEYDARIVTFGTWLYSVNKEQLARAGFYALGEGDKVKC 299

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLL++KGQEYINNIHLTHSL E +VRT EKTP
Sbjct: 300 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLGESVVRTAEKTP 359

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           S+T++IDDTIFQNPMVQEAIRMGF+FKDIKK MEEK+Q SGSNY SLEVL+ADLV+AQKD
Sbjct: 360 SVTKKIDDTIFQNPMVQEAIRMGFNFKDIKKTMEEKLQTSGSNYLSLEVLIADLVSAQKD 419

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           + QDESSQTSLQK+IST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 420 NSQDESSQTSLQKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 479

Query: 585 CPMCYTVITFKQKIF 599
           CPMC TVITFKQK  
Sbjct: 480 CPMCCTVITFKQKFL 494



>gi|11890719|gb|AAG41192.1|   inhibitor of apoptosis protein 3 [Rattus norvegicus]
          Length = 501

 Score =  929 bits (2400), Expect = 0.0
 Identities = 431/495 (87%), Positives = 460/495 (92%), Gaps = 1/495 (0%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEGS+T VPAD NK+EEFVEEFNRLKTFANFPS SPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGSRTVVPADTNKDEEFVEEFNRLKTFANFPSSSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           V+CFSCHAAVDRWQYGDSAVGRHR++SPNCRFINGFY EN ATQST+ GIQNGQYK EN 
Sbjct: 61  VQCFSCHAAVDRWQYGDSAVGRHRRISPNCRFINGFYFENGATQSTSPGIQNGQYKSENC 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           +G+R+HFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM SEEARLK+FQNWPDYAHL+
Sbjct: 121 VGNRNHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMCSEEARLKTFQNWPDYAHLS 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTGI DQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRN+N+RSE
Sbjct: 181 PRELASAGLYYTGIDDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVNVRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           S  VSSDRNFPNSTN PRNP+MA+Y+ARI TFGTW+YSVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 S-GVSSDRNFPNSTNSPRNPAMAEYDARIVTFGTWLYSVNKEQLARAGFYALGEGDKVKC 299

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGL DWKPSEDPWEQHAKWYPGCKYLL++KGQEYINNIHLTHSL E +VRT EKTP
Sbjct: 300 FHCGGGLADWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLGESVVRTAEKTP 359

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           S+T++IDDTIFQNPMVQEAIRMGF+FKDIKK MEEK+Q SGSNY SLEVL+ADLV+AQKD
Sbjct: 360 SVTKKIDDTIFQNPMVQEAIRMGFNFKDIKKTMEEKLQTSGSNYLSLEVLIADLVSAQKD 419

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           + QDESSQTSLQK+IST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 420 NSQDESSQTSLQKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 479

Query: 585 CPMCYTVITFKQKIF 599
           CPMC TVITFKQK  
Sbjct: 480 CPMCCTVITFKQKFL 494



>gi|2497241|sp|Q60989|BIR4_MOUSE   Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis
           protein 3) (X-linked inhibitor of apoptosis protein)
           (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3)
 gi|1145261|gb|AAC52594.1|   MIHA
          Length = 496

 Score =  924 bits (2389), Expect = 0.0
 Identities = 433/497 (87%), Positives = 458/497 (92%), Gaps = 1/497 (0%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEG++T V AD NK+EEFVEEFNRLKTFANFPS SPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGTRTFVLADTNKDEEFVEEFNRLKTFANFPSSSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           V+CFSCHAA+DRWQYGDSAVGRHR++SPNCRFINGFY EN A QSTN GIQNGQYK EN 
Sbjct: 61  VQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFINGFYFENGAAQSTNPGIQNGQYKSENC 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           +G+R+ FA DRP ETHADYLLRTGQVVDISDTIYPRNPAM SEEARLKSFQNWPDYAHLT
Sbjct: 121 VGNRNPFAPDRPPETHADYLLRTGQVVDISDTIYPRNPAMCSEEARLKSFQNWPDYAHLT 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTG  DQVQCFCCGGKL+NWEPCDRAWSEHRRHFPNCFFVLGRN+N+RSE
Sbjct: 181 PRELASAGLYYTGADDQVQCFCCGGKLENWEPCDRAWSEHRRHFPNCFFVLGRNVNVRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           S  VSSDRNFPNSTN PRNP+MA+YEARI TFGTW  SVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 S-GVSSDRNFPNSTNSPRNPAMAEYEARIVTFGTWTSSVNKEQLARAGFYALGEGDKVKC 299

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLL++KGQEYINNIHLTHSLEE L RT EKTP
Sbjct: 300 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQEYINNIHLTHSLEESLGRTAEKTP 359

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
           SLT++IDDTIFQNPMVQEAIRMGFSFKDIKK MEEKIQ SGS+Y SLEVL+ADLV+AQKD
Sbjct: 360 SLTKKIDDTIFQNPMVQEAIRMGFSFKDIKKTMEEKIQTSGSSYLSLEVLIADLVSAQKD 419

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           + +DESSQTSLQK+IST          KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
Sbjct: 420 NTEDESSQTSLQKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 479

Query: 585 CPMCYTVITFKQKIFMS 601
           CPMCYTVITFKQKIFMS
Sbjct: 480 CPMCYTVITFKQKIFMS 496



>gi|6753088|ref|NP_033818.1|   baculoviral IAP repeat-containing 4; apoptosis inhibitor 3;
           X-linked inhibitor of apoptosis [Mus musculus]
 gi|2138319|gb|AAB58376.1|   X-linked inhibitor of apoptosis [Mus musculus]
          Length = 496

 Score =  905 bits (2339), Expect = 0.0
 Identities = 425/497 (85%), Positives = 451/497 (90%), Gaps = 1/497 (0%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MTFNSFEG++T V AD NK+EEFVEEFNRLKTFANFPS SPVSASTLARAGFLYTGEGDT
Sbjct: 1   MTFNSFEGTRTFVLADTNKDEEFVEEFNRLKTFANFPSSSPVSASTLARAGFLYTGEGDT 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY 224
           V+CFSCHAA+DRWQYGDSAVGRHR++SPNCRFINGFY EN A QSTN GIQNGQYK EN 
Sbjct: 61  VQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFINGFYFENGAAQSTNPGIQNGQYKSENC 120

Query: 225 LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT 284
           +G+R+ FA DRP ETHADYLLRTGQVVDISDTIYPRNPAM SEEARLKSFQNWPDYAHLT
Sbjct: 121 VGNRNPFAPDRPPETHADYLLRTGQVVDISDTIYPRNPAMCSEEARLKSFQNWPDYAHLT 180

Query: 285 PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           PRELASAGLYYTG  DQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRN+N+RSE
Sbjct: 181 PRELASAGLYYTGADDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNVNVRSE 240

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           S  VSSDRNFPNSTN PRNP+MA+YEARI TFGTW  SVNKEQLARAGFYALGEGDKVKC
Sbjct: 241 S-GVSSDRNFPNSTNSPRNPAMAEYEARIVTFGTWTSSVNKEQLARAGFYALGEGDKVKC 299

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP 464
           FHCGGGLTDWKPSEDPW+QHAK YPGCKYLL++KGQEYINNIHLTH LEE L RT EKTP
Sbjct: 300 FHCGGGLTDWKPSEDPWDQHAKCYPGCKYLLDEKGQEYINNIHLTHPLEESLGRTAEKTP 359

Query: 465 SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD 524
            LT++IDDTIFQNPMVQEAIRMGFSFKD+KK MEEKIQ SGS+Y SLEVL+ADLV+AQKD
Sbjct: 360 PLTKKIDDTIFQNPMVQEAIRMGFSFKDLKKTMEEKIQTSGSSYLSLEVLIADLVSAQKD 419

Query: 525 SMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK 584
           + +DESSQTSLQK+IST          KL KICMDRNIAIVF PCGHL TCKQCAEAVDK
Sbjct: 420 NTEDESSQTSLQKDISTEEQLRRLQEEKLSKICMDRNIAIVFFPCGHLATCKQCAEAVDK 479

Query: 585 CPMCYTVITFKQKIFMS 601
           CPMCYTVITF QKIFMS
Sbjct: 480 CPMCYTVITFNQKIFMS 496



>gi|17865297|gb|AAL47170.1|   inhibitor of apoptosis protein 3 [Gallus gallus]
          Length = 493

 Score =  579 bits (1492), Expect = e-164
 Identities = 278/502 (55%), Positives = 360/502 (71%), Gaps = 16/502 (3%)

Query: 105 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT 164
           MT N  + S++      + ++E+ +E  RL TF  FP   PVSAS LARAGF+YTGEGD 
Sbjct: 1   MTCNGPDSSESGATPATDGDQEWTQEHYRLGTFVEFPHDCPVSASALARAGFVYTGEGDK 60

Query: 165 VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFING-FYLENSATQSTNSGIQNGQYKVEN 223
           V+CFSCH  V+ W+ GDSA+ RH+ +SP+CRFI G  +LEN+     +  +Q+ Q++ EN
Sbjct: 61  VKCFSCHVTVEGWEPGDSAIDRHKNLSPDCRFITGSAFLENN----VHPLVQSHQHRTEN 116

Query: 224 YLGSRD---HFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDY 280
             GS +     AL+  S+  ADYLLRT QVVD+SDT+YP+NPAM SEEARLKSF NWP Y
Sbjct: 117 --GSSNLALPSALEDLSDVEADYLLRTRQVVDMSDTLYPKNPAMCSEEARLKSFHNWPPY 174

Query: 281 AHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNL- 339
             LTP+ELASAGLYYTG+GDQV CFCCGGKLKNWEP DRAWSEH+RHFP CFFVLGR++ 
Sbjct: 175 GLLTPKELASAGLYYTGVGDQVACFCCGGKLKNWEPGDRAWSEHKRHFPKCFFVLGRDVG 234

Query: 340 NIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEG 399
           N+ ++S      R+  N+   PRNPSMA+YE RI TF  WIY VNKE LA AGFY+ G G
Sbjct: 235 NVSTDSICAELGRSCLNNEQHPRNPSMAEYERRIQTFLAWIYPVNKEHLAEAGFYSTGNG 294

Query: 400 DKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRT 459
           D V CFHCGGGL +WK +EDPW+QHAKW+PGCK+L ++KG E+INN+HL     +  +  
Sbjct: 295 DHVVCFHCGGGLQEWKENEDPWDQHAKWFPGCKFLRDEKGLEFINNVHLRDGCRDSTIEA 354

Query: 460 TEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLV 519
            E    +T    D + QN +VQ AI MGFS  +I+ IME+K+ +SG +Y S+E LVADL+
Sbjct: 355 AE----VTILPKDDLLQNQLVQNAIHMGFSLSEIRSIMEKKLHLSGESYTSVEDLVADLI 410

Query: 520 NAQKDSMQDESSQTS-LQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQC 578
           +AQK++++ E  + S L++++S           KLCKICM ++I++V +PCGHLV CK+C
Sbjct: 411 SAQKENIKGEPPKESPLEQDLSIEEKLRRLQEEKLCKICMAKDISVVLIPCGHLVACKEC 470

Query: 579 AEAVDKCPMCYTVITFKQKIFM 600
           AEAV+KCP+C T I  +QKIFM
Sbjct: 471 AEAVNKCPLCCTNIIKRQKIFM 492



>gi|21759007|sp|Q95M72|BIR8_PANTR   Baculoviral IAP repeat-containing protein 8 (Inhibitor of
           apoptosis-like protein 2) (IAP-like protein 2) (ILP-2)
 gi|14522827|gb|AAK49776.1|   IAP-like protein 2 [Pan troglodytes]
          Length = 236

 Score =  402 bits (1034), Expect = e-111
 Identities = 180/236 (76%), Positives = 207/236 (87%)

Query: 366 MADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHA 425
           M  YEAR+ TFGTW+Y VNKEQLARAGFYA+G+ DKV+CFHCGGGL +WKP EDPWEQHA
Sbjct: 1   MTGYEARLITFGTWMYFVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHA 60

Query: 426 KWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIR 485
           KWYPGCKYLLE+KG EYINNIHLT SLE  LV+TT+KTPSLT+RI+DTIF NPM+QEAIR
Sbjct: 61  KWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRINDTIFPNPMLQEAIR 120

Query: 486 MGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTXXXX 545
           MGF FKD+KKIMEE+IQ SGSNYK+LEVLVADLV+AQKD+ ++ES+QTSLQ+EIS     
Sbjct: 121 MGFDFKDVKKIMEERIQTSGSNYKTLEVLVADLVSAQKDTTENESNQTSLQREISPEEPL 180

Query: 546 XXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
                 KLCKICMDR+IA+VF+PCGHLVTCKQCAEAVD+CPMC  VI FKQ++FMS
Sbjct: 181 RRLQDEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS 236



 Score = 66.6 bits (161), Expect = 2e-09
 Identities = 30/72 (41%), Positives = 42/72 (58%), Gaps = 2/72 (2%)

Query: 264 MYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSE 323
           M   EARL +F  W  +  +   +LA AG Y  G  D+VQCF CGG L NW+P +  W +
Sbjct: 1   MTGYEARLITFGTWMYF--VNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQ 58

Query: 324 HRRHFPNCFFVL 335
           H + +P C ++L
Sbjct: 59  HAKWYPGCKYLL 70



 Score = 43.1 bits (100), Expect = 0.018
 Identities = 18/52 (34%), Positives = 28/52 (53%)

Query: 146 VSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFI 197
           V+   LARAGF   G+ D V+CF C   +  W+  +    +H K  P C+++
Sbjct: 18  VNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYPGCKYL 69



>gi|44680139|ref|NP_203127.3|   baculoviral IAP repeat-containing 8; IAP-like protein 2 [Homo
           sapiens]
 gi|15042064|gb|AAK81892.1|   IAP-like protein 2 [Homo sapiens]
          Length = 236

 Score =  402 bits (1033), Expect = e-110
 Identities = 180/236 (76%), Positives = 206/236 (87%)

Query: 366 MADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHA 425
           M  YEAR+ TFGTW+YSVNKEQLARAGFYA+G+ DKV+CFHCGGGL +WKP EDPWEQHA
Sbjct: 1   MTGYEARLITFGTWMYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHA 60

Query: 426 KWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIR 485
           KWYPGCKYLLE+KG EYINNIHLT SLE  LV+TT+KTPSLT+RI DTIF NPM+QEAIR
Sbjct: 61  KWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIR 120

Query: 486 MGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTXXXX 545
           MGF FKD+KKIMEE+IQ SGSNYK+LEVLVADLV+AQKD+ ++E +QTSLQ+EIS     
Sbjct: 121 MGFDFKDVKKIMEERIQTSGSNYKTLEVLVADLVSAQKDTTENELNQTSLQREISPEEPL 180

Query: 546 XXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
                 KLCKICMDR+IA+VF+PCGHLVTCKQCAEAVD+CPMC  VI FKQ++FMS
Sbjct: 181 RRLQEEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS 236



 Score = 66.2 bits (160), Expect = 2e-09
 Identities = 30/72 (41%), Positives = 41/72 (56%), Gaps = 2/72 (2%)

Query: 264 MYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSE 323
           M   EARL +F  W     +   +LA AG Y  G  D+VQCF CGG L NW+P +  W +
Sbjct: 1   MTGYEARLITFGTW--MYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQ 58

Query: 324 HRRHFPNCFFVL 335
           H + +P C ++L
Sbjct: 59  HAKWYPGCKYLL 70



 Score = 43.9 bits (102), Expect = 0.012
 Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 2/65 (3%)

Query: 133 RLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSP 192
           RL TF  +     V+   LARAGF   G+ D V+CF C   +  W+  +    +H K  P
Sbjct: 7   RLITFGTWMYS--VNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYP 64

Query: 193 NCRFI 197
            C+++
Sbjct: 65  GCKYL 69



>gi|21759006|sp|Q95M71|BIR8_GORGO   Baculoviral IAP repeat-containing protein 8 (Inhibitor of
           apoptosis-like protein 2) (IAP-like protein 2) (ILP-2)
 gi|14522829|gb|AAK49777.1|   IAP-like protein 2 [Gorilla gorilla]
          Length = 236

 Score =  401 bits (1031), Expect = e-110
 Identities = 181/236 (76%), Positives = 206/236 (87%)

Query: 366 MADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHA 425
           M  YEA + TFGTW+YSVNKEQLARAGFYA+G+ DK++CFHCGGGL +WKP EDPWEQHA
Sbjct: 1   MTGYEAWLITFGTWMYSVNKEQLARAGFYAIGQEDKIQCFHCGGGLANWKPKEDPWEQHA 60

Query: 426 KWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIR 485
           KWYPGCKYLLE+KG EYINNIHLT SLE  LV+TT+KTPSLT+RI DTIF NPM+QEAIR
Sbjct: 61  KWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIR 120

Query: 486 MGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTXXXX 545
           MGF FKDIKKIMEEKIQ SGSNYK+LEVLVADLV+AQKD+ ++ES+QTSLQ+EIS     
Sbjct: 121 MGFDFKDIKKIMEEKIQTSGSNYKTLEVLVADLVSAQKDTTENESNQTSLQREISPEEPL 180

Query: 546 XXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
                 KLCKICMDR+IA+VF+PCGHLVTCKQCAEAVD+CPMC  VI FKQ++FMS
Sbjct: 181 RRLQEEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCNAVIDFKQRVFMS 236



 Score = 62.4 bits (150), Expect = 3e-08
 Identities = 28/72 (38%), Positives = 40/72 (55%), Gaps = 2/72 (2%)

Query: 264 MYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSE 323
           M   EA L +F  W     +   +LA AG Y  G  D++QCF CGG L NW+P +  W +
Sbjct: 1   MTGYEAWLITFGTW--MYSVNKEQLARAGFYAIGQEDKIQCFHCGGGLANWKPKEDPWEQ 58

Query: 324 HRRHFPNCFFVL 335
           H + +P C ++L
Sbjct: 59  HAKWYPGCKYLL 70



 Score = 42.7 bits (99), Expect = 0.027
 Identities = 17/52 (32%), Positives = 28/52 (53%)

Query: 146 VSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFI 197
           V+   LARAGF   G+ D ++CF C   +  W+  +    +H K  P C+++
Sbjct: 18  VNKEQLARAGFYAIGQEDKIQCFHCGGGLANWKPKEDPWEQHAKWYPGCKYL 69



>gi|21759009|sp|Q96P09|BIR8_HUMAN   Baculoviral IAP repeat-containing protein 8 (Inhibitor of
           apoptosis-like protein 2) (IAP-like protein 2) (ILP-2)
           (Testis-specific inhibitor of apoptosis)
 gi|16902898|gb|AAL30369.1|   testis-specific inhibitor of apoptosis [Homo sapiens]
          Length = 236

 Score =  401 bits (1030), Expect = e-110
 Identities = 180/236 (76%), Positives = 205/236 (86%)

Query: 366 MADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHA 425
           M  YEAR+ TFGTW+YSVNKEQLARAGFYA+G+ DKV+CFHCGGGL +WKP EDPWEQHA
Sbjct: 1   MTGYEARLITFGTWMYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHA 60

Query: 426 KWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIR 485
           KWYPGCKYLLE+KG EYINNIHLT SLE  LV+TT+KTPSLT+RI DTIF NPM+QEAIR
Sbjct: 61  KWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIR 120

Query: 486 MGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTXXXX 545
           MGF FKD+KKIMEE+IQ SGSNYK+LEVLVADLV+AQKD+ ++E +QTSLQ+EIS     
Sbjct: 121 MGFDFKDVKKIMEERIQTSGSNYKTLEVLVADLVSAQKDTTENELNQTSLQREISPEEPL 180

Query: 546 XXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
                 KLCKICMDR IA+VF+PCGHLVTCKQCAEAVD+CPMC  VI FKQ++FMS
Sbjct: 181 RRLQEEKLCKICMDRYIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS 236



 Score = 66.2 bits (160), Expect = 2e-09
 Identities = 30/72 (41%), Positives = 41/72 (56%), Gaps = 2/72 (2%)

Query: 264 MYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSE 323
           M   EARL +F  W     +   +LA AG Y  G  D+VQCF CGG L NW+P +  W +
Sbjct: 1   MTGYEARLITFGTW--MYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQ 58

Query: 324 HRRHFPNCFFVL 335
           H + +P C ++L
Sbjct: 59  HAKWYPGCKYLL 70



 Score = 43.9 bits (102), Expect = 0.011
 Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 2/65 (3%)

Query: 133 RLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSP 192
           RL TF  +     V+   LARAGF   G+ D V+CF C   +  W+  +    +H K  P
Sbjct: 7   RLITFGTWMYS--VNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYP 64

Query: 193 NCRFI 197
            C+++
Sbjct: 65  GCKYL 69



>gi|35902986|ref|NP_919377.1|   baculoviral IAP repeat-containing 4 [Danio rerio]
 gi|16930775|gb|AAL32047.1|   Xiap [Danio rerio]
          Length = 405

 Score =  341 bits (874), Expect = 4e-92
 Identities = 192/470 (40%), Positives = 264/470 (56%), Gaps = 92/470 (19%)

Query: 132 NRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVS 191
           NR+ +F  FP    +SA  LARAGF +TGEGD V+CFSC A V  W  GD+ + RH+  S
Sbjct: 24  NRVNSFQRFPYSEDISAQRLARAGFYFTGEGDRVQCFSCSATVQNWNRGDTPLERHQLAS 83

Query: 192 PNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVV 251
           P+CRF+           S   G++N      N + S D+   D  +E   ++LLRTG+VV
Sbjct: 84  PDCRFL-----------SCAHGMRN-----SNSIQSPDY---DEEAENR-EFLLRTGEVV 123

Query: 252 DISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKL 311
           D  +++YP  P M SEEARL +F NWP  + + P +LA AG+YY GI D VQCFCCGG L
Sbjct: 124 D--ESMYPVVPHMKSEEARLSTFNNWPADSPVRPEDLAEAGMYYIGIDDNVQCFCCGGGL 181

Query: 312 KNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPR-NPSMAD-Y 369
             WE  D  WSEH +++ NCFF LG N+             N P +T  PR N    D +
Sbjct: 182 SGWEQGDDPWSEHAKYYSNCFFFLGHNVG------------NVPLTTPRPRANVHPTDTF 229

Query: 370 EARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYP 429
           E R+ +F    + ++ E+LARAGFY+ GE D+V CF CGGG+  W P EDPWE+HA+ YP
Sbjct: 230 EGRLDSFKGRQHPIDPERLARAGFYSTGEQDRVMCFRCGGGVKAWMPDEDPWEEHARHYP 289

Query: 430 GCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFS 489
           GC +LL +KG+EY++++ L +           K P+          QN         GFS
Sbjct: 290 GCSFLLAEKGEEYVSSVQLRYP----------KRPT----------QN---------GFS 320

Query: 490 FKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTXXXXXXXX 549
             +           SGS+ ++L    +D+    +D M   +    LQ+E           
Sbjct: 321 SHE-----------SGSSAQALIHGSSDMFEKAEDPM---TELEKLQRE----------- 355

Query: 550 XXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIF 599
             KLCK+CMD +I+IVF+PCGHLVTC++C+ ++DKCP+C   IT K K +
Sbjct: 356 --KLCKVCMDSDISIVFIPCGHLVTCQKCSASLDKCPICCATITQKIKTY 403



>gi|32766697|gb|AAH55246.1|   Birc4 protein [Danio rerio]
          Length = 415

 Score =  338 bits (866), Expect = 3e-91
 Identities = 189/470 (40%), Positives = 260/470 (55%), Gaps = 93/470 (19%)

Query: 132 NRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVS 191
           NR+ +F  FP    +SA  LARAGF +TGEGD V+CFSC A V  W  GD+ + RH+  S
Sbjct: 35  NRVNSFQRFPYSEDISAQRLARAGFYFTGEGDRVQCFSCSATVQNWNRGDTPLERHQLAS 94

Query: 192 PNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVV 251
           P+CRF+           S   G++N      N + S D+   D  +E   ++LLRTG+VV
Sbjct: 95  PDCRFL-----------SCAHGMRN-----SNSIQSPDY---DEEAENR-EFLLRTGEVV 134

Query: 252 DISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKL 311
           D  +++YP  P M SEEARL +F NWP  + + P +LA AG+YY GI D VQCFCCGG L
Sbjct: 135 D--ESMYPVVPHMKSEEARLSTFNNWPADSPVRPEDLAEAGMYYIGIDDNVQCFCCGGGL 192

Query: 312 KNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPR-NPSMAD-Y 369
             WE  D  WSEH +++ NCFF LG N+             N P +T  PR N    D +
Sbjct: 193 SGWEQGDDPWSEHAKYYSNCFFFLGHNVG------------NVPLTTPRPRVNVHPTDTF 240

Query: 370 EARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYP 429
           E R+ +F    + ++ E+LARAGFY+ GE D+V CF CGGG+  W P EDPWE+HA+ YP
Sbjct: 241 EGRLDSFKGRQHPIDPERLARAGFYSTGEQDRVMCFRCGGGVKAWMPDEDPWEEHARHYP 300

Query: 430 GCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFS 489
           GC +LL +KG+EY++++ L +           K P+          QN         GFS
Sbjct: 301 GCSFLLAEKGEEYVSSVQLRYP----------KRPT----------QN---------GFS 331

Query: 490 FKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTXXXXXXXX 549
             +           SG + ++       L++   D  +     T L+K            
Sbjct: 332 SHE-----------SGPSAQA-------LIHGSSDMFEKADPMTELEK----------LQ 363

Query: 550 XXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIF 599
             KLCK+CMD +I+IVF+PCGHLVTC++C+ ++DKCP+C   IT K K +
Sbjct: 364 REKLCKVCMDSDISIVFIPCGHLVTCQKCSASLDKCPICCATITQKIKTY 413



>gi|13786998|pdb|1I4O|C   Chain C, Crystal Structure Of The XiapCASPASE-7 Complex
 gi|13786999|pdb|1I4O|D   Chain D, Crystal Structure Of The XiapCASPASE-7 Complex
          Length = 141

 Score =  314 bits (805), Expect = 4e-84
 Identities = 141/141 (100%), Positives = 141/141 (100%)

Query: 224 YLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHL 283
           YLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHL
Sbjct: 1   YLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHL 60

Query: 284 TPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRS 343
           TPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRS
Sbjct: 61  TPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRS 120

Query: 344 ESDAVSSDRNFPNSTNLPRNP 364
           ESDAVSSDRNFPNSTNLPRNP
Sbjct: 121 ESDAVSSDRNFPNSTNLPRNP 141



 Score = 75.5 bits (184), Expect = 4e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 356 NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 413
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 31  SDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKN 90

Query: 414 WKPSEDPWEQHAKWYPGCKYLL 435
           W+P +  W +H + +P C ++L
Sbjct: 91  WEPCDRAWSEHRRHFPNCFFVL 112



 Score = 63.5 bits (153), Expect = 1e-08
 Identities = 30/70 (42%), Positives = 40/70 (57%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  RLK+F N+P  + ++   LA AG  YTG GD V+CF C   +  W+  D A   HR+
Sbjct: 44  EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRR 103

Query: 190 VSPNCRFING 199
             PNC F+ G
Sbjct: 104 HFPNCFFVLG 113



>gi|27903492|gb|AAO24632.1|   inhibitor of apoptosis protein-1 [Ictalurus punctatus]
          Length = 616

 Score =  294 bits (753), Expect = 4e-78
 Identities = 171/443 (38%), Positives = 234/443 (52%), Gaps = 57/443 (12%)

Query: 114 KTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAA 173
           +T  PAD+  +     E  R+ TFA FPS +PV+  +LARAGF YTG  D V+CF C+  
Sbjct: 15  RTSAPADLQYDN--TSELFRISTFAKFPSTAPVTERSLARAGFFYTGICDRVQCFRCNVT 72

Query: 174 VDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFAL 233
           +D WQ G+    RH+++SPNC FI       +   S++S            L +     L
Sbjct: 73  IDNWQTGECPAERHKQMSPNCAFIQSLPSTANLLSSSHSAFSP--------LRNATILQL 124

Query: 234 DRPSETHAD--------YL----------LRTGQVVDISDTIYP---RNPAMYSEEARLK 272
           + P+ T A         YL          L +  V D+S    P    NP+M  E+ RL 
Sbjct: 125 NLPAVTSASGQTDEQVGYLNMSNLAPSSPLSSRGVEDMSHQ-RPSACHNPSMRREQDRLD 183

Query: 273 SFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCF 332
           +FQNW     +TP ELA AG YY   GD+V CF CGG L NWEP DRA SEH+RH+PNC 
Sbjct: 184 TFQNW-TLTTITPAELAKAGFYYLSQGDRVACFSCGGHLSNWEPGDRAMSEHQRHYPNCR 242

Query: 333 FVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLAR 390
           FV G        +D +S      N +    NP+M   E R+ TF  W     V  +QLA+
Sbjct: 243 FVRG------DRADNISIAGGLANVS----NPAMQQCEERLLTFVNWPARIPVRPDQLAK 292

Query: 391 AGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--L 448
           AGFY +G  D VKCF C GGL  W+  +DPW +HAKW+P C+YLL++KGQE+++ I    
Sbjct: 293 AGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLQEKGQEFVHQIQARF 352

Query: 449 THSLEECLVRTTEKT----------PSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIME 498
               E+ L     +           P   R  D  +   P+V+ A+ MGF    +K+ ++
Sbjct: 353 PRLFEQLLNNGDSREFVDPPVVHLGPGEERSEDAVMMNTPVVKAALEMGFDRNLVKQTVQ 412

Query: 499 EKIQISGSNYKSLEVLVADLVNA 521
            KI  SG NYK+++ LV+DL++A
Sbjct: 413 SKILTSGENYKTVQELVSDLLSA 435



 Score = 68.2 bits (165), Expect = 6e-10
 Identities = 24/50 (48%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ + IVF+PCGHLV CK+CA ++ KCP+C  ++    + F+S
Sbjct: 567 RTCKVCMDKEVNIVFIPCGHLVVCKECAPSLRKCPICRGMVKGTVRTFLS 616



>gi|33414037|gb|AAP04483.1|   inhibitor of apoptosis protein [Danio rerio]
          Length = 647

 Score =  291 bits (744), Expect = 4e-77
 Identities = 173/451 (38%), Positives = 237/451 (52%), Gaps = 61/451 (13%)

Query: 114 KTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAA 173
           +T  PAD+  +     E  R+ T+A FP+ + V+  +LARAGF YTG GD V+CF C+  
Sbjct: 34  RTSGPADLQYDNS--SELFRISTYAKFPTTAAVTERSLARAGFYYTGLGDRVQCFRCNVT 91

Query: 174 VDRWQYGDSAVGRHRKVSPNCRFINGF-----------------------YLENSATQST 210
            D WQ GD    RH+++SPNC FI                           L   AT + 
Sbjct: 92  ADNWQSGDCPAERHKQLSPNCSFIQSLPATANLLSSSHSAFSPLRNVAVLQLSAPATAAP 151

Query: 211 NSGIQNGQYKVENYLGSRDH-FALDRPSETHADYLLRTGQVVDISDTIYP--RNPAMYSE 267
           ++   +   + E  +G  +  F    PS       + +  V D+S    P   NP M  E
Sbjct: 152 STTAPSTSGQTEEQVGYLNMGFTNLAPSSP-----ISSRGVEDMSHQRPPACHNPGMRRE 206

Query: 268 EARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRH 327
           + RL +FQNW   A +TP ELA AGLYY G GD+V CF CGG+L +WEP DRA SEH+RH
Sbjct: 207 QERLDTFQNWT-LATVTPAELAKAGLYYLGQGDRVACFSCGGQLGSWEPGDRAVSEHQRH 265

Query: 328 FPNCFFVLG-RNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVN 384
           +PNC FV G R  NI      +S   N  NS       +M   E R+ TF  W     V 
Sbjct: 266 YPNCRFVRGDRADNIPLSGGGLS---NVSNS-------AMQQCEERLLTFVNWPSRIPVR 315

Query: 385 KEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYIN 444
            +QLA+AGFY +G  D VKCF C GGL  W+  +DPW +HAKW+P C+YLL++KGQE+++
Sbjct: 316 PDQLAKAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLQEKGQEFVH 375

Query: 445 NIH--LTHSLEECLVRTTEKT------------PSLTRRIDDTIFQNPMVQEAIRMGFSF 490
            I        E+ L      +            P   R  D  +  NP+V+ A+ MGF  
Sbjct: 376 QIQARFPRLFEQLLTNGDSNSREFVDPPVVHLGPGEDRSEDAVMMNNPVVKSALEMGFER 435

Query: 491 KDIKKIMEEKIQISGSNYKSLEVLVADLVNA 521
             +K+ ++ KI  SG NYK+++ LV+DL++A
Sbjct: 436 GLVKQTVQSKILTSGENYKTVQELVSDLLSA 466



 Score = 68.2 bits (165), Expect = 6e-10
 Identities = 24/50 (48%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ + IVF+PCGHLV CK+CA ++ KCP+C  ++    + F+S
Sbjct: 598 RTCKVCMDKEVNIVFIPCGHLVVCKECAPSLRKCPICRGMVKGTVRTFLS 647



>gi|37359682|emb|CAE47763.1|   SI:bZ1P14.6.2 (baculoviral IAP repeat-containing 3 ) [Danio rerio]
          Length = 654

 Score =  291 bits (744), Expect = 4e-77
 Identities = 173/451 (38%), Positives = 237/451 (52%), Gaps = 61/451 (13%)

Query: 114 KTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAA 173
           +T  PAD+  +     E  R+ T+A FP+ + V+  +LARAGF YTG GD V+CF C+  
Sbjct: 41  RTSGPADLQYDNS--SELFRISTYAKFPTTAAVTERSLARAGFYYTGLGDRVQCFRCNVT 98

Query: 174 VDRWQYGDSAVGRHRKVSPNCRFINGF-----------------------YLENSATQST 210
            D WQ GD    RH+++SPNC FI                           L   AT + 
Sbjct: 99  ADNWQSGDCPAERHKQLSPNCSFIQSLPATANLLSSSHSAFSPLRNVAVLQLSAPATAAP 158

Query: 211 NSGIQNGQYKVENYLGSRDH-FALDRPSETHADYLLRTGQVVDISDTIYP--RNPAMYSE 267
           ++   +   + E  +G  +  F    PS       + +  V D+S    P   NP M  E
Sbjct: 159 STTAPSTSGQTEEQVGYLNMGFTNLAPSSP-----ISSRGVEDMSHQRPPACHNPGMRRE 213

Query: 268 EARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRH 327
           + RL +FQNW   A +TP ELA AGLYY G GD+V CF CGG+L +WEP DRA SEH+RH
Sbjct: 214 QERLDTFQNWT-LATVTPAELAKAGLYYLGQGDRVACFSCGGQLGSWEPGDRAVSEHQRH 272

Query: 328 FPNCFFVLG-RNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVN 384
           +PNC FV G R  NI      +S   N  NS       +M   E R+ TF  W     V 
Sbjct: 273 YPNCRFVRGDRADNIPLSGGGLS---NVSNS-------AMQQCEERLLTFVNWPSRIPVR 322

Query: 385 KEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYIN 444
            +QLA+AGFY +G  D VKCF C GGL  W+  +DPW +HAKW+P C+YLL++KGQE+++
Sbjct: 323 PDQLAKAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLQEKGQEFVH 382

Query: 445 NIH--LTHSLEECLVRTTEKT------------PSLTRRIDDTIFQNPMVQEAIRMGFSF 490
            I        E+ L      +            P   R  D  +  NP+V+ A+ MGF  
Sbjct: 383 QIQARFPRLFEQLLTNGDSNSREFVDPPVVHLGPGEDRSEDAVMMNNPVVKSALEMGFER 442

Query: 491 KDIKKIMEEKIQISGSNYKSLEVLVADLVNA 521
             +K+ ++ KI  SG NYK+++ LV+DL++A
Sbjct: 443 GLVKQTVQSKILTSGENYKTVQELVSDLLSA 473



 Score = 68.2 bits (165), Expect = 6e-10
 Identities = 24/50 (48%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ + IVF+PCGHLV CK+CA ++ KCP+C  ++    + F+S
Sbjct: 605 RTCKVCMDKEVNIVFIPCGHLVVCKECAPSLRKCPICRGMVKGTVRTFLS 654



>gi|35902971|ref|NP_919376.1|   baculoviral IAP repeat-containing 3 [Danio rerio]
 gi|17017468|gb|AAL33679.1|   Iap1 [Danio rerio]
          Length = 628

 Score =  290 bits (741), Expect = 8e-77
 Identities = 173/451 (38%), Positives = 237/451 (52%), Gaps = 61/451 (13%)

Query: 114 KTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAA 173
           +T  PAD+  +     E  R+ T+A FP+ + V+  +LARAGF YTG GD V+CF C+  
Sbjct: 15  RTSGPADLQYDNS--SELFRISTYAKFPTTAAVTERSLARAGFYYTGLGDRVQCFRCNVT 72

Query: 174 VDRWQYGDSAVGRHRKVSPNCRFINGF-----------------------YLENSATQST 210
            D WQ GD    RH+++SPNC FI                           L   AT + 
Sbjct: 73  ADNWQSGDCPAERHKQLSPNCSFIQSLPATANLLSSSHSAFSPLRNVAVLQLSAPATAAP 132

Query: 211 NSGIQNGQYKVENYLGSRDH-FALDRPSETHADYLLRTGQVVDISDTIYP--RNPAMYSE 267
           ++   +   + E  +G  +  F    PS       + +  V D+S    P   NP M  E
Sbjct: 133 STTAPSTSGQTEEQVGYLNMGFTNLAPSSP-----ISSRGVEDMSHQRPPACHNPGMRRE 187

Query: 268 EARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRH 327
           + RL +FQNW   A +TP ELA AGLYY G GD+V CF CGG+L +WEP DRA SEH+RH
Sbjct: 188 QERLDTFQNWT-LATVTPAELAKAGLYYLGQGDRVACFSCGGQLGSWEPGDRAVSEHQRH 246

Query: 328 FPNCFFVLG-RNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVN 384
           +PNC FV G R  NI      +S   N  NS       +M   E R+ TF  W     V 
Sbjct: 247 YPNCRFVRGDRADNIPLSGGGLS---NVSNS-------AMQQCEERLLTFVNWPSRIPVR 296

Query: 385 KEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYIN 444
            +QLA+AGFY +G  D VKCF C GGL  W+  +DPW +HAKW+P C+YLL++KGQE+++
Sbjct: 297 PDQLAKAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLLQEKGQEFVH 356

Query: 445 NIH--LTHSLEECLVRTTEKT------------PSLTRRIDDTIFQNPMVQEAIRMGFSF 490
            I        E+ L      +            P   R  D  +  NP+V+ A+ MGF  
Sbjct: 357 QIQARFPRLFEQLLTNGDSNSREFVDPPVVHLGPGEDRSEDAVMMNNPVVKSALEMGFER 416

Query: 491 KDIKKIMEEKIQISGSNYKSLEVLVADLVNA 521
             +K+ ++ KI  SG NYK+++ LV+DL++A
Sbjct: 417 GLVKQTVQSKILTSGENYKTVQELVSDLLSA 447



 Score = 68.2 bits (165), Expect = 6e-10
 Identities = 24/50 (48%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ + IVF+PCGHLV CK+CA ++ KCP+C  ++    + F+S
Sbjct: 579 RTCKVCMDKEVNIVFIPCGHLVVCKECAPSLRKCPICRGMVKGTVRTFLS 628



>gi|2656127|gb|AAB88044.1|   IAP homolog [Gallus gallus]
          Length = 610

 Score =  287 bits (735), Expect = 4e-76
 Identities = 174/429 (40%), Positives = 229/429 (53%), Gaps = 66/429 (15%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  R+ TF+ FP   PVS   LARAGF YTG  D V+CFSC   +D WQ GD+A+ +H++
Sbjct: 30  ELYRMSTFSTFPVNVPVSERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQ 89

Query: 190 VSPNCRFINGFYLENSATQSTNSG-----------------IQNGQYKVENYLGSRDHFA 232
           V P+C F+      N+   ST+S                  +     +V  + GS   F 
Sbjct: 90  VYPSCSFVQNMLSLNNLGLSTHSAFSPLVASNLSPSLRSMTLSPSFEQVGYFSGSFSSFP 149

Query: 233 LDRPSETHADYL--LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELAS 290
            D  +   A+ L  LR+             NP+M +EEARL++F  WP    L+P ELA 
Sbjct: 150 QDPVTTRAAEDLSHLRSKL----------HNPSMSTEEARLRTFHAWP-LMFLSPAELAK 198

Query: 291 AGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSS 350
           AGLYY G  D+V CF CGG+L NWEP D A SEHRRHFPNC FV   NL     S  VS 
Sbjct: 199 AGLYYLGTADKVACFTCGGQLSNWEPKDNAMSEHRRHFPNCPFV--ENLMRDQPSFNVS- 255

Query: 351 DRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYALGEGDKVKCFHCG 408
                       N +M  +EAR+ TF  W     V  EQLA AGFY +G  D VKCF C 
Sbjct: 256 ------------NVTMQTHEARVKTFINWPTRIPVQPEQLADAGFYYVGRNDDVKCFCCD 303

Query: 409 GGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEKTPSL 466
           GGL  W+  +DPW +HAKW+P C+YLL  KG E+++ +     H LE+ L  +T  TP +
Sbjct: 304 GGLRCWESGDDPWIEHAKWFPRCEYLLRVKGGEFVSQVQARFPHLLEQLL--STSDTP-V 360

Query: 467 TRRID-------------DTIFQN-PMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLE 512
              +D             D I  N P+V+ A+ MGFS + IK+ ++ KI  +  NYK++ 
Sbjct: 361 DENMDPIIHFEPGESPSEDAIMMNTPVVKAALEMGFSRRLIKQTVQSKILATEENYKTVN 420

Query: 513 VLVADLVNA 521
            LV+DL+ A
Sbjct: 421 DLVSDLLTA 429



 Score = 70.1 bits (170), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ ++IVF+PCGHLV CK+CA ++ KCP+C   I    + F+S
Sbjct: 561 RTCKVCMDKEVSIVFIPCGHLVVCKECAPSLRKCPICRGTIKGTVRTFLS 610



>gi|4502141|ref|NP_001157.1|   baculoviral IAP repeat-containing protein 2; apoptosis inhibitor 1;
           cIAP1; hiap-2; NFR2-TRAF signalling complex protein
           [Homo sapiens]
 gi|2497238|sp|Q13490|BIR2_HUMAN   Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis
           protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF
           signaling complex protein 2) (IAP homolog B)
 gi|1145293|gb|AAC50508.1|   MIHB
 gi|1160973|gb|AAC41942.1|   TNFR2-TRAF signalling complex protein
 gi|16740585|gb|AAH16174.1|   Baculoviral IAP repeat-containing protein 2 [Homo sapiens]
 gi|22382084|gb|AAH28578.1|   BIRC2 protein [Homo sapiens]
 gi|1586946|prf||2205253A   c-IAP1 protein
          Length = 618

 Score =  283 bits (725), Expect = 6e-75
 Identities = 161/420 (38%), Positives = 228/420 (54%), Gaps = 48/420 (11%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           +F  E  R+ T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS + 
Sbjct: 42  DFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQ 101

Query: 186 RHRKVSPNCRFINGFYLENSATQSTNSGIQNGQY------KVENYLGSRDHFALDRPSET 239
           +H+++ P+C FI      +  + S N+      +       +E+       ++   P+  
Sbjct: 102 KHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNP- 160

Query: 240 HADYLLRTGQVVDISDT-IYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGI 298
                L +  V DIS +   P + AM +EEAR  ++  WP    L+P ELA AG YY G 
Sbjct: 161 -----LNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWP-LTFLSPSELARAGFYYIGP 214

Query: 299 GDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNST 358
           GD+V CF CGGKL NWEP D A SEHRRHFPNC F+      +R           F  S 
Sbjct: 215 GDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLR-----------FSIS- 262

Query: 359 NLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLTDWKP 416
               N SM  + AR+ TF  W  SV    EQLA AGFY +G  D VKCF C GGL  W+ 
Sbjct: 263 ----NLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWES 318

Query: 417 SEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEKT----------- 463
            +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L+ T++ T           
Sbjct: 319 GDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQ-LLSTSDTTGEENADPPIIH 377

Query: 464 --PSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNA 521
             P  +   D  +   P+V+ A+ MGF+   +K+ ++ KI  +G NYK++  +V+ L+NA
Sbjct: 378 FGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNA 437



 Score = 68.9 bits (167), Expect = 4e-10
 Identities = 23/50 (46%), Positives = 38/50 (76%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ +++VF+PCGHLV C++CA ++ KCP+C  +I    + F+S
Sbjct: 569 RTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS 618



 Score = 62.4 bits (150), Expect = 4e-08
 Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)

Query: 340 NIRS--ESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYA 395
           NI+S  E   + SD    N   +  + S   Y  R+ T+ T+     V++  LARAGFY 
Sbjct: 17  NIKSIMEDSTILSDWTNSNKQKMKYDFSCELY--RMSTYSTFPAGVPVSERSLARAGFYY 74

Query: 396 LGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL 434
            G  DKVKCF CG  L +WK  + P ++H + YP C ++
Sbjct: 75  TGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFI 113



>gi|7512288|pir||S68450   apoptosis inhibitor hiap-2 - human
 gi|1184318|gb|AAC50372.1|   inhibitor of apoptosis protein 2
          Length = 618

 Score =  281 bits (718), Expect = 4e-74
 Identities = 161/420 (38%), Positives = 227/420 (54%), Gaps = 48/420 (11%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           +F  E  R+ T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS + 
Sbjct: 42  DFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQ 101

Query: 186 RHRKVSPNCRFINGFYLENSATQSTNSGIQNGQY------KVENYLGSRDHFALDRPSET 239
           +H+++ P+C FI      +  + S N+      +       +E+       ++   P+  
Sbjct: 102 KHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLPPNP- 160

Query: 240 HADYLLRTGQVVDISDT-IYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGI 298
                L +  V DIS +   P + AM +EEAR  ++  WP    L+P ELA AG YY G 
Sbjct: 161 -----LNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWP-LTFLSPSELARAGFYYIGP 214

Query: 299 GDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNST 358
           GD+V CF CGGKL NWEP D A SEHRRHFPNC F+      +R           F  S 
Sbjct: 215 GDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLR-----------FSIS- 262

Query: 359 NLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLTDWKP 416
               N SM  + AR+ TF  W  SV    EQLA AGFY +G  D VKCF C GGL  W+ 
Sbjct: 263 ----NLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFGCDGGLRCWES 318

Query: 417 SEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEKT----------- 463
            +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L+ T++ T           
Sbjct: 319 GDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQ-LLSTSDTTGEENADPPIIH 377

Query: 464 --PSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNA 521
             P  +   D  +   P+V+ A+ MGF+   +K+ +  KI  +G NYK++  +V+ L+NA
Sbjct: 378 FGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVLSKILTTGENYKTVNDIVSALLNA 437



 Score = 68.9 bits (167), Expect = 3e-10
 Identities = 23/50 (46%), Positives = 38/50 (76%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ +++VF+PCGHLV C++CA ++ KCP+C  +I    + F+S
Sbjct: 569 RTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS 618



 Score = 62.4 bits (150), Expect = 3e-08
 Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)

Query: 340 NIRS--ESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYA 395
           NI+S  E   + SD    N   +  + S   Y  R+ T+ T+     V++  LARAGFY 
Sbjct: 17  NIKSIMEDSTILSDWTNSNKQKMKYDFSCELY--RMSTYSTFPAGVPVSERSLARAGFYY 74

Query: 396 LGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL 434
            G  DKVKCF CG  L +WK  + P ++H + YP C ++
Sbjct: 75  TGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFI 113



>gi|25140579|gb|AAN73272.1|   pRb-interacting protein RbBP-36 [Homo sapiens]
          Length = 534

 Score =  280 bits (715), Expect = 1e-73
 Identities = 160/420 (38%), Positives = 227/420 (54%), Gaps = 48/420 (11%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           +F  E  R+ T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS + 
Sbjct: 42  DFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQ 101

Query: 186 RHRKVSPNCRFINGFYLENSATQSTNSGIQNGQY------KVENYLGSRDHFALDRPSET 239
           +H+++ P+C FI      +  + S N+      +       +E+       ++   P+  
Sbjct: 102 KHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNP- 160

Query: 240 HADYLLRTGQVVDISDT-IYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGI 298
                L +  V DIS +   P + AM +EEAR  ++  WP    L+P ELA AG  Y G 
Sbjct: 161 -----LNSRAVEDISSSRTNPYSHAMSTEEARFLTYHMWP-LTFLSPSELARAGFDYIGP 214

Query: 299 GDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNST 358
           GD+V CF CGGKL NWEP D A SEHRRHFPNC F+      +R           F  S 
Sbjct: 215 GDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLR-----------FSIS- 262

Query: 359 NLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLTDWKP 416
               N SM  + AR+ TF  W  SV    EQLA AGFY +G  D VKCF C GGL  W+ 
Sbjct: 263 ----NLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWES 318

Query: 417 SEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEKT----------- 463
            +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L+ T++ T           
Sbjct: 319 GDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQ-LLSTSDTTGEENADPPIIH 377

Query: 464 --PSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNA 521
             P  +   D  +   P+V+ A+ MGF+   +K+ ++ KI  +G NYK++  +V+ L+NA
Sbjct: 378 FGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNA 437



 Score = 62.0 bits (149), Expect = 4e-08
 Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 6/99 (6%)

Query: 340 NIRS--ESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYA 395
           NI+S  E   + SD    N   +  + S   Y  R+ T+ T+     V++  LARAGFY 
Sbjct: 17  NIKSIMEDSTILSDWTNSNKQKMKYDFSCELY--RMSTYSTFPAGVPVSERSLARAGFYY 74

Query: 396 LGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL 434
            G  DKVKCF CG  L +WK  + P ++H + YP C ++
Sbjct: 75  TGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFI 113



>gi|2497239|sp|Q62210|BIR2_MOUSE   Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis
           protein 2) (MIAP2) (MIAP-2)
 gi|1161128|gb|AAC42078.1|   TNFR2-TRAF signalling complex protein
 gi|1586948|prf||2205253C   c-IAP1 protein
          Length = 612

 Score =  278 bits (712), Expect = 2e-73
 Identities = 168/439 (38%), Positives = 237/439 (53%), Gaps = 62/439 (14%)

Query: 114 KTCVPADINKEEE------FVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRC 167
           K+ + ++  KE E      F  E  R+ T++ FP G PVS  +LARAGF YTG  D V+C
Sbjct: 24  KSTILSNWTKESEEKMKFDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKC 83

Query: 168 FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGS 227
           F C   +D W+ GDS V +HR+  P+C F+    L +++ QS +          +N    
Sbjct: 84  FCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQT--LLSASLQSPS----------KNMSPV 131

Query: 228 RDHFALDRPSE---THADYL---LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYA 281
           +  FA   P E    H++     L +  V D S  + P + AM +EEAR  ++  WP  +
Sbjct: 132 KSRFAHSSPLERGGIHSNLCSSPLNSRAVEDFSSRMDPCSYAMSTEEARFLTYSMWP-LS 190

Query: 282 HLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNI 341
            L+P ELA AG YY G GD+V CF CGGKL NWEP D A SEHRRHFP+C F+       
Sbjct: 191 FLSPAELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPHCPFL------- 243

Query: 342 RSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEG 399
               +  S  + F  S     N SM  + AR+ TF  W  SV    EQLA AGFY +   
Sbjct: 244 ----ENTSETQRFSIS-----NLSMQTHSARLRTFLYWPPSVPVQPEQLASAGFYYVDRN 294

Query: 400 DKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLV 457
           D VKCF C GGL  W+P +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L 
Sbjct: 295 DDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLL- 353

Query: 458 RTTEKTP-----SLTRRI----------DDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQ 502
            +T  TP       T  +          D  +   P+V+ A+ MGFS   +++ ++ +I 
Sbjct: 354 -STSDTPGEENADPTETVVHFGPGESSEDVVMMSTPVVKAALEMGFSRSLVRQTVQRQIL 412

Query: 503 ISGSNYKSLEVLVADLVNA 521
            +G NY+++  +V+ L+NA
Sbjct: 413 ATGENYRTVNDIVSVLLNA 431



 Score = 69.7 bits (169), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMDR ++IVF+PCGHLV C++CA ++ KCP+C   I    + F+S
Sbjct: 563 RTCKVCMDREVSIVFIPCGHLVVCQECAPSLRKCPICRGTIKGTVRTFLS 612



>gi|6680698|ref|NP_031491.1|   baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2
           [Mus musculus]
 gi|2062676|gb|AAC53532.1|   inhibitor of apoptosis protein 2 [Mus musculus]
          Length = 612

 Score =  278 bits (712), Expect = 2e-73
 Identities = 168/439 (38%), Positives = 237/439 (53%), Gaps = 62/439 (14%)

Query: 114 KTCVPADINKEEE------FVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRC 167
           K+ + ++  KE E      F  E  R+ T++ FP G PVS  +LARAGF YTG  D V+C
Sbjct: 24  KSTILSNWTKESEEKMKFDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKC 83

Query: 168 FSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGS 227
           F C   +D W+ GDS V +HR+  P+C F+    L +++ QS +          +N    
Sbjct: 84  FCCGLMLDNWKQGDSPVEKHRQFYPSCSFVQT--LLSASLQSPS----------KNMSPV 131

Query: 228 RDHFALDRPSE---THADYL---LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYA 281
           +  FA   P E    H++     L +  V D S  + P + AM +EEAR  ++  WP  +
Sbjct: 132 KSRFAHSSPLERGGIHSNLCSSPLNSRAVEDFSSRMDPCSYAMSTEEARFLTYSMWP-LS 190

Query: 282 HLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNI 341
            L+P ELA AG YY G GD+V CF CGGKL NWEP D A SEHRRHFP+C F+       
Sbjct: 191 FLSPAELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPHCPFL------- 243

Query: 342 RSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEG 399
               +  S  + F  S     N SM  + AR+ TF  W  SV    EQLA AGFY +   
Sbjct: 244 ----ENTSETQRFSIS-----NLSMQTHSARLRTFLYWPPSVPVQPEQLASAGFYYVDRN 294

Query: 400 DKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLV 457
           D VKCF C GGL  W+P +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L 
Sbjct: 295 DDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLL- 353

Query: 458 RTTEKTP-----SLTRRI----------DDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQ 502
            +T  TP       T  +          D  +   P+V+ A+ MGFS   +++ ++ +I 
Sbjct: 354 -STSDTPGEENADPTETVVHFGPGESSKDVVMMSTPVVKAALEMGFSRSLVRQTVQRQIL 412

Query: 503 ISGSNYKSLEVLVADLVNA 521
            +G NY+++  +V+ L+NA
Sbjct: 413 ATGENYRTVNDIVSVLLNA 431



 Score = 69.7 bits (169), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMDR ++IVF+PCGHLV C++CA ++ KCP+C   I    + F+S
Sbjct: 563 RTCKVCMDREVSIVFIPCGHLVVCQECAPSLRKCPICRGTIKGTVRTFLS 612



>gi|11120700|ref|NP_068520.1|   apoptosis inhibitor 2 [Rattus norvegicus]
 gi|6164925|gb|AAF04585.1|   inhibitor of apoptosis protein 2 [Rattus norvegicus]
          Length = 589

 Score =  278 bits (711), Expect = 2e-73
 Identities = 165/424 (38%), Positives = 232/424 (54%), Gaps = 53/424 (12%)

Query: 122 NKEE---EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQ 178
           NKE+   +F  E  R+ T++ FP G PVS  +LARAGF YTG  D V+CF C   +D W+
Sbjct: 14  NKEKMKYDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWK 73

Query: 179 YGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSE 238
            GDS   +HR+  P+C F+             + G+Q+     +N   ++  FA   P E
Sbjct: 74  QGDSPTEKHRQFYPSCSFVQTLL---------SGGLQSA---AKNTSPAKSRFAHSLPLE 121

Query: 239 THADYL------LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAG 292
               +       L +  V D S  + P + AM +EEAR  S+  WP  + L+P ELA AG
Sbjct: 122 QGGIHSSLPSNPLNSRAVEDFSLRMNPCSYAMSTEEARFLSYSMWP-LSFLSPAELAKAG 180

Query: 293 LYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDR 352
            YYTG GD+V CF CGGKL NWEP D   SEHRRHFP+C F+           +  S  +
Sbjct: 181 FYYTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPHCPFL-----------ENTSETQ 229

Query: 353 NFPNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGG 410
            F  S     N SM  + AR+ TF  W  SV    EQLA AGFY +   D VKCF C GG
Sbjct: 230 RFSVS-----NLSMQTHSARMSTFLYWPSSVLVQPEQLASAGFYYVDHNDDVKCFCCDGG 284

Query: 411 LTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVR--TTEKT--- 463
           L  W+P +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L    T+E+    
Sbjct: 285 LRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLLSTSDTSEEENAD 344

Query: 464 PSLT-----RRIDDTIFQN-PMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVAD 517
           P +         +D +  N P+V+ A+ MGFS   +++ ++ +I  +G NY+++  +V+ 
Sbjct: 345 PPVVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSDIVSA 404

Query: 518 LVNA 521
           L+NA
Sbjct: 405 LLNA 408



 Score = 70.1 bits (170), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMDR ++IVF+PCGHLV C++CA ++ KCP+C   I    + F+S
Sbjct: 540 RTCKVCMDREVSIVFIPCGHLVVCRECAPSLRKCPICRGTIKGTVRTFLS 589



>gi|38541348|gb|AAH62055.1|   Apoptosis inhibitor 2 [Rattus norvegicus]
          Length = 589

 Score =  278 bits (711), Expect = 3e-73
 Identities = 165/424 (38%), Positives = 232/424 (54%), Gaps = 53/424 (12%)

Query: 122 NKEE---EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQ 178
           NKE+   +F  E  R+ T++ FP G PVS  +LARAGF YTG  D V+CF C   +D W+
Sbjct: 14  NKEKMKYDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWK 73

Query: 179 YGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSE 238
            GDS   +HR+  P+C F+             + G+Q+     +N   ++  FA   P E
Sbjct: 74  QGDSPTEKHRQFYPSCSFVQTLL---------SGGLQSA---AKNTSPAKSRFAHSLPLE 121

Query: 239 THADYL------LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAG 292
               +       L +  V D S  + P + AM +EEAR  S+  WP  + L+P ELA AG
Sbjct: 122 QGGIHSSLPSNPLNSRAVEDFSLRMNPCSYAMSTEEARFLSYSMWP-LSFLSPAELAKAG 180

Query: 293 LYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDR 352
            YYTG GD+V CF CGGKL NWEP D   SEHRRHFP+C F+           +  S  +
Sbjct: 181 FYYTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPHCPFL-----------ENTSETQ 229

Query: 353 NFPNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGG 410
            F  S     N SM  + AR+ TF  W  SV    EQLA AGFY +   D VKCF C GG
Sbjct: 230 RFSVS-----NLSMQTHSARMRTFLYWPSSVLVQPEQLASAGFYYVDHNDDVKCFCCDGG 284

Query: 411 LTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVR--TTEKT--- 463
           L  W+P +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L    T+E+    
Sbjct: 285 LRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLLSTSDTSEEENAD 344

Query: 464 PSLT-----RRIDDTIFQN-PMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVAD 517
           P +         +D +  N P+V+ A+ MGFS   +++ ++ +I  +G NY+++  +V+ 
Sbjct: 345 PPVVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSDIVSA 404

Query: 518 LVNA 521
           L+NA
Sbjct: 405 LLNA 408



 Score = 70.1 bits (170), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMDR ++IVF+PCGHLV C++CA ++ KCP+C   I    + F+S
Sbjct: 540 RTCKVCMDREVSIVFIPCGHLVVCRECAPSLRKCPICRGTIKGTVRTFLS 589



>gi|10765285|gb|AAG22971.1|   inhibitor of apoptosis protein 2 [Rattus norvegicus]
          Length = 589

 Score =  276 bits (707), Expect = 9e-73
 Identities = 166/426 (38%), Positives = 231/426 (54%), Gaps = 57/426 (13%)

Query: 122 NKEE---EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQ 178
           NKE+   +F  E  R+ T++ FP G PVS  +LARAGF YTG  D V+CF C   +D W+
Sbjct: 14  NKEKMKYDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWK 73

Query: 179 YGDSAVGRHRKVSPNCRFINGFYLE--NSATQSTNSGIQNGQYKVENYLGSRDHFALDRP 236
            GDS   +HR+  P+C F+         SA +ST+               ++  FA   P
Sbjct: 74  QGDSPTEKHRQFYPSCSFVQTLLSGGLQSAAKSTSP--------------AKSRFAHSLP 119

Query: 237 SETHADYL------LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELAS 290
            E    +       L +  V D S  + P + AM +EEAR  S+  WP  + L+P ELA 
Sbjct: 120 LEQGGIHSSLPSNPLNSRAVEDFSLRMNPCSYAMSTEEARFLSYSMWP-LSFLSPAELAK 178

Query: 291 AGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSS 350
           AG YYTG GD+V CF CGGKL NWEP D   SEHRRHFP+C F+           +  S 
Sbjct: 179 AGFYYTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPHCPFL-----------ENTSE 227

Query: 351 DRNFPNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCG 408
            + F  S     N SM  + AR+ TF  W  SV    EQLA AGFY +   D VKCF C 
Sbjct: 228 TQRFSVS-----NLSMQTHSARMSTFLYWPSSVLVQPEQLASAGFYYVDHNDDVKCFCCD 282

Query: 409 GGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVR--TTEKT- 463
           GGL  W+P +DPW +HAKW+P C++L+  KGQE+++ I     H LE+ L    T+E+  
Sbjct: 283 GGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLLSTSDTSEEEN 342

Query: 464 --PSLT-----RRIDDTIFQN-PMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLV 515
             P +         +D +  N P+V+ A+ MGFS   +++ ++ +I  +G NY+++  +V
Sbjct: 343 ADPPVVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSDIV 402

Query: 516 ADLVNA 521
           + L+NA
Sbjct: 403 SALLNA 408



 Score = 70.1 bits (170), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMDR ++IVF+PCGHLV C++CA ++ KCP+C   I    + F+S
Sbjct: 540 RTCKVCMDREVSIVFIPCGHLVVCRECAPSLRKCPICRGTIKGTVRTFLS 589



>gi|5669090|gb|AAD46161.1|   API2-MLT fusion protein [Homo sapiens]
          Length = 1140

 Score =  273 bits (697), Expect = 1e-71
 Identities = 159/411 (38%), Positives = 215/411 (52%), Gaps = 59/411 (14%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  R+ T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS   +H+K
Sbjct: 29  ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88

Query: 190 VSPNCRFINGFYLEN------------SATQSTNS---GIQNGQYKVENYLGSRDHFALD 234
           + P+CRF+      N            S T ST+S   G +N  Y   +Y  S  +    
Sbjct: 89  LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNS 148

Query: 235 RPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLY 294
           R ++  +  L+R+             + AM +E ARL +FQ WP    L+P +LA AG Y
Sbjct: 149 RANQDFSA-LMRSSY-----------HCAMNNENARLLTFQTWP-LTFLSPTDLAKAGFY 195

Query: 295 YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNF 354
           Y G GD+V CF CGGKL NWEP D A SEH RHFP C F+         E+    + R  
Sbjct: 196 YIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFI---------ENQLQDTSRYT 246

Query: 355 PNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLT 412
            +      N SM  + AR  TF  W  SV  N EQLA AGFY +G  D VKCF C GGL 
Sbjct: 247 VS------NLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR 300

Query: 413 DWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHS-LEECLVRTTEK--------- 462
            W+  +DPW QHAKW+P C+YL+  KGQE+I  +  ++  L E L+ T++          
Sbjct: 301 CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS 360

Query: 463 ----TPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYK 509
                P      D  +   P++  A+ MGFS   +K+ ++ KI  +G NY+
Sbjct: 361 IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYR 411



 Score = 65.1 bits (157), Expect = 5e-09
 Identities = 41/113 (36%), Positives = 60/113 (53%), Gaps = 7/113 (6%)

Query: 339 LNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYAL 396
           +NI   S  +S+     N+  L  + S   Y  R+ T+ T+     V++  LARAGFY  
Sbjct: 1   MNIVENSIFLSNLMKSANTFELKYDLSCELY--RMSTYSTFPAGVPVSERSLARAGFYYT 58

Query: 397 GEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT 449
           G  DKVKCF CG  L +WK  + P E+H K YP C+++   +    +NN+  T
Sbjct: 59  GVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFV---QSLNSVNNLEAT 108



>gi|7512287|pir||S68449   apoptosis inhibitor hiap-1 - human
 gi|1184316|gb|AAC50371.1|   inhibitor of apoptosis protein 1
          Length = 604

 Score =  272 bits (696), Expect = 2e-71
 Identities = 160/411 (38%), Positives = 215/411 (52%), Gaps = 59/411 (14%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  R+ T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS   +H+K
Sbjct: 29  ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88

Query: 190 VSPNCRFINGFYLEN------------SATQSTNS---GIQNGQYKVENYLGSRDHFALD 234
           + P+CRF+      N            S T ST+S   G +N  Y   +Y  S  +    
Sbjct: 89  LYPSCRFVQSLNSVNNLEATSQPTFPSSVTHSTHSLLPGTENSGYFRGSYSNSPSNPVNS 148

Query: 235 RPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLY 294
           R ++  +  L+R+          YP    M +E ARL +FQ WP    L+P +LA AG Y
Sbjct: 149 RANQEFSA-LMRSS---------YP--CPMNNENARLLTFQTWP-LTFLSPTDLARAGFY 195

Query: 295 YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNF 354
           Y G GD+V CF CGGKL NWEP D A SEH RHFP C F+         E+    + R  
Sbjct: 196 YIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFI---------ENQLQDTSRYT 246

Query: 355 PNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLT 412
            +      N SM  + AR  TF  W  SV  N EQLA AGFY +G  D VKCF C GGL 
Sbjct: 247 VS------NLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR 300

Query: 413 DWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHS-LEECLVRTTEK--------- 462
            W+  +DPW QHAKW+P C+YL+  KGQE+I  +  ++  L E L+ T++          
Sbjct: 301 CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS 360

Query: 463 ----TPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYK 509
                P      D  +   P++  A+ MGFS   +K+ ++ KI  +G NY+
Sbjct: 361 IIHLEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYR 411



 Score = 69.7 bits (169), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ ++IVF+PCGHLV CK CA ++ KCP+C + I    + F+S
Sbjct: 555 RTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 604



 Score = 65.1 bits (157), Expect = 5e-09
 Identities = 41/113 (36%), Positives = 60/113 (53%), Gaps = 7/113 (6%)

Query: 339 LNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYAL 396
           +NI   S  +S+     N+  L  + S   Y  R+ T+ T+     V++  LARAGFY  
Sbjct: 1   MNIVENSIFLSNLMKSANTFELKYDLSCELY--RMSTYSTFPAGVPVSERSLARAGFYYT 58

Query: 397 GEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT 449
           G  DKVKCF CG  L +WK  + P E+H K YP C+++   +    +NN+  T
Sbjct: 59  GVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFV---QSLNSVNNLEAT 108



>gi|13027446|ref|NP_076477.1|   inhibitor of apoptosis protein 1 [Rattus norvegicus]
 gi|10765283|gb|AAG22970.1|   inhibitor of apoptosis protein 1 [Rattus norvegicus]
          Length = 602

 Score =  272 bits (695), Expect = 2e-71
 Identities = 161/427 (37%), Positives = 230/427 (53%), Gaps = 54/427 (12%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           +F  E  RL T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS + 
Sbjct: 25  DFSCELYRLSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPIE 84

Query: 186 RHRKVSPNCRFINGFYLENS------------ATQSTNSGIQNGQYKVENYLGSRDHFAL 233
           +HRK+ P+C F+      NS            AT +  SG    +     + GS   F  
Sbjct: 85  KHRKLYPSCSFVQTLNPANSLEASPQPPLPSTATSTMPSGFAASE-STGYFSGSYSSFPS 143

Query: 234 DRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGL 293
           D  +        R  Q      T  P + AM +E+ARL ++Q WP  + L+P ELA AG 
Sbjct: 144 DPVN-------FRANQDCPAFST-SPYHFAMNTEKARLLTYQTWP-LSFLSPAELAKAGF 194

Query: 294 YYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRN 353
           YYTG GD+V CF CGGKL NW+  D   SEHRRHFP+C F+  +++   +    VS    
Sbjct: 195 YYTGPGDRVACFACGGKLSNWDRKDDPLSEHRRHFPSCPFL--KDVGQFTSQYTVS---- 248

Query: 354 FPNSTNLPRNPSMADYEARIFTFGTWIYS--VNKEQLARAGFYALGEGDKVKCFHCGGGL 411
                    N SM  + AR+ TF TW  S  V+ ++LA AGFY  G  D VKCF C GGL
Sbjct: 249 ---------NLSMQTHAARVRTFSTWPSSALVHPQELASAGFYYTGHSDDVKCFCCDGGL 299

Query: 412 TDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEKTPSLT-- 467
             W+  +DPW +HAKW+P C+YL+  KGQE++  +     H LE+ L+ T++     T  
Sbjct: 300 RCWESGDDPWVEHAKWFPRCEYLIRIKGQEFVGQVQAGYPHLLEQ-LLSTSDSPEDETGE 358

Query: 468 ---------RRIDDTIFQN-PMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVAD 517
                       +D +  N P+V+ A+ MGFS   +++ ++ +I  +G NY+++  LV  
Sbjct: 359 AAIVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSDLVIG 418

Query: 518 LVNAQKD 524
           L++A+ +
Sbjct: 419 LLDAEDE 425



 Score = 68.6 bits (166), Expect = 5e-10
 Identities = 25/50 (50%), Positives = 36/50 (72%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMDR  ++VF+PCGHLV CK+CA ++ KCP+C   I    + F+S
Sbjct: 553 RTCKVCMDREASLVFIPCGHLVVCKECAPSLRKCPICRGTIKGTVRTFLS 602



>gi|3978244|gb|AAC83232.1|   inhibitor of apoptosis protein-1 [Homo sapiens]
          Length = 604

 Score =  271 bits (694), Expect = 3e-71
 Identities = 159/411 (38%), Positives = 215/411 (52%), Gaps = 59/411 (14%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  R+ T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS   +H+K
Sbjct: 29  ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88

Query: 190 VSPNCRFINGFYLEN------------SATQSTNS---GIQNGQYKVENYLGSRDHFALD 234
           + P+CRF+      N            S T ST+S   G +N  Y   +Y  S  +    
Sbjct: 89  LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNS 148

Query: 235 RPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLY 294
           R ++  +  L+R+             + AM +E ARL +FQ WP    L+P +LA AG Y
Sbjct: 149 RANQDFSA-LMRSSY-----------HCAMNNENARLLTFQTWP-LTFLSPTDLAKAGFY 195

Query: 295 YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNF 354
           Y G GD+V CF CGGKL NWEP D A SEH RHFP C F+         E+    + R  
Sbjct: 196 YIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFI---------ENQLQDTSRYT 246

Query: 355 PNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLT 412
            +      N SM  + AR  TF  W  SV  N EQLA AGFY +G  D VKCF C GGL 
Sbjct: 247 VS------NLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR 300

Query: 413 DWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHS-LEECLVRTTEK--------- 462
            W+  +DPW QHAKW+P C+YL+  KGQE+I  +  ++  L E L+ T++          
Sbjct: 301 CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS 360

Query: 463 ----TPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYK 509
                P      D  +   P++  A+ MGFS   +K+ ++ KI  +G NY+
Sbjct: 361 IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYR 411



 Score = 69.7 bits (169), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ ++IVF+PCGHLV CK CA ++ KCP+C + I    + F+S
Sbjct: 555 RTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 604



>gi|4502139|ref|NP_001156.1|   baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2;
           TNFR2-TRAF signaling complex protein; mammalian IAP
           homolog C; inhibitor of apoptosis protein 1 [Homo
           sapiens]
 gi|33946285|ref|NP_892007.1|   baculoviral IAP repeat-containing protein 3; apoptosis inhibitor 2;
           TNFR2-TRAF signaling complex protein; mammalian IAP
           homolog C; inhibitor of apoptosis protein 1 [Homo
           sapiens]
 gi|2497236|sp|Q13489|BIR3_HUMAN   Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis
           protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF
           signaling complex protein 1) (IAP homolog C) (Apoptosis
           inhibitor 2) (API2)
 gi|1145291|gb|AAC50507.1|   MIHC
 gi|1160975|gb|AAC41943.1|   TNFR2-TRAF signalling complex protein
 gi|22766816|gb|AAH37420.1|   Baculoviral IAP repeat-containing protein 3 [Homo sapiens]
 gi|1586947|prf||2205253B   c-IAP2 protein
          Length = 604

 Score =  271 bits (694), Expect = 3e-71
 Identities = 159/411 (38%), Positives = 215/411 (52%), Gaps = 59/411 (14%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  R+ T++ FP+G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS   +H+K
Sbjct: 29  ELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKK 88

Query: 190 VSPNCRFINGFYLEN------------SATQSTNS---GIQNGQYKVENYLGSRDHFALD 234
           + P+CRF+      N            S T ST+S   G +N  Y   +Y  S  +    
Sbjct: 89  LYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNS 148

Query: 235 RPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLY 294
           R ++  +  L+R+             + AM +E ARL +FQ WP    L+P +LA AG Y
Sbjct: 149 RANQDFSA-LMRSSY-----------HCAMNNENARLLTFQTWP-LTFLSPTDLAKAGFY 195

Query: 295 YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNF 354
           Y G GD+V CF CGGKL NWEP D A SEH RHFP C F+         E+    + R  
Sbjct: 196 YIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFI---------ENQLQDTSRYT 246

Query: 355 PNSTNLPRNPSMADYEARIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLT 412
            +      N SM  + AR  TF  W  SV  N EQLA AGFY +G  D VKCF C GGL 
Sbjct: 247 VS------NLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR 300

Query: 413 DWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHS-LEECLVRTTEK--------- 462
            W+  +DPW QHAKW+P C+YL+  KGQE+I  +  ++  L E L+ T++          
Sbjct: 301 CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS 360

Query: 463 ----TPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYK 509
                P      D  +   P++  A+ MGFS   +K+ ++ KI  +G NY+
Sbjct: 361 IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYR 411



 Score = 69.7 bits (169), Expect = 2e-10
 Identities = 25/50 (50%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           + CK+CMD+ ++IVF+PCGHLV CK CA ++ KCP+C + I    + F+S
Sbjct: 555 RTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 604



 Score = 64.7 bits (156), Expect = 6e-09
 Identities = 41/113 (36%), Positives = 60/113 (53%), Gaps = 7/113 (6%)

Query: 339 LNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYAL 396
           +NI   S  +S+     N+  L  + S   Y  R+ T+ T+     V++  LARAGFY  
Sbjct: 1   MNIVENSIFLSNLMKSANTFELKYDLSCELY--RMSTYSTFPAGVPVSERSLARAGFYYT 58

Query: 397 GEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLT 449
           G  DKVKCF CG  L +WK  + P E+H K YP C+++   +    +NN+  T
Sbjct: 59  GVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFV---QSLNSVNNLEAT 108



>gi|18655901|pdb|1KMC|C   Chain C, Crystal Structure Of The Caspase-7  XIAP-Bir2 Complex
 gi|18655902|pdb|1KMC|D   Chain D, Crystal Structure Of The Caspase-7  XIAP-Bir2 Complex
          Length = 119

 Score =  266 bits (681), Expect = 9e-70
 Identities = 118/119 (99%), Positives = 118/119 (99%)

Query: 228 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE 287
           RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMY EEARLKSFQNWPDYAHLTPRE
Sbjct: 1   RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYCEEARLKSFQNWPDYAHLTPRE 60

Query: 288 LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESD 346
           LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESD
Sbjct: 61  LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESD 119



 Score = 74.3 bits (181), Expect = 8e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 356 NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 413
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 27  SDTIYPRNPAMYCEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKN 86

Query: 414 WKPSEDPWEQHAKWYPGCKYLL 435
           W+P +  W +H + +P C ++L
Sbjct: 87  WEPCDRAWSEHRRHFPNCFFVL 108



 Score = 63.5 bits (153), Expect = 1e-08
 Identities = 30/70 (42%), Positives = 40/70 (57%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  RLK+F N+P  + ++   LA AG  YTG GD V+CF C   +  W+  D A   HR+
Sbjct: 40  EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRR 99

Query: 190 VSPNCRFING 199
             PNC F+ G
Sbjct: 100 HFPNCFFVLG 109



>gi|13096729|pdb|1G73|C   Chain C, Crystal Structure Of Smac Bound To Xiap-Bir3 Domain
 gi|13096730|pdb|1G73|D   Chain D, Crystal Structure Of Smac Bound To Xiap-Bir3 Domain
          Length = 121

 Score =  266 bits (680), Expect = 1e-69
 Identities = 121/121 (100%), Positives = 121/121 (100%)

Query: 342 RSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDK 401
           RSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDK
Sbjct: 1   RSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDK 60

Query: 402 VKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTE 461
           VKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTE
Sbjct: 61  VKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTE 120

Query: 462 K 462
           K
Sbjct: 121 K 121



 Score = 75.1 bits (183), Expect = 5e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 254 SDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKN 313
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 15  NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 72

Query: 314 WEPCDRAWSEHRRHFPNCFFVL 335
           W+P +  W +H + +P C ++L
Sbjct: 73  WKPSEDPWEQHAKWYPGCKYLL 94



 Score = 47.4 bits (111), Expect = 0.001
 Identities = 20/52 (38%), Positives = 29/52 (55%)

Query: 146 VSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFI 197
           V+   LARAGF   GEGD V+CF C   +  W+  +    +H K  P C+++
Sbjct: 42  VNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL 93



>gi|6680696|ref|NP_031490.1|   baculoviral IAP repeat-containing 2; apoptosis inhibitor 1 [Mus
           musculus]
 gi|2497237|sp|O08863|BIR3_MOUSE   Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis
           protein 1) (MIAP1) (MIAP-1)
 gi|2062674|gb|AAC53531.1|   inhibitor of apoptosis protein 1 [Mus musculus]
          Length = 600

 Score =  264 bits (675), Expect = 5e-69
 Identities = 158/427 (37%), Positives = 224/427 (52%), Gaps = 54/427 (12%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           +F  E  RL T++ FP G PVS  +LARAGF YTG  D V+CF C   +D W+ GDS + 
Sbjct: 23  DFSCELYRLSTYSAFPRGVPVSERSLARAGFYYTGANDKVKCFCCGLMLDNWKQGDSPME 82

Query: 186 RHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKV--------EN---YLGSRDHFALD 234
           +HRK+ P+C F+      NS   S    + +             EN   + GS   F  D
Sbjct: 83  KHRKLYPSCNFVQTLNPANSLEASPRPSLPSTAMSTMPLSFASSENTGYFSGSYSSFPSD 142

Query: 235 RPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLY 294
             +        R  Q      T  P + AM +E+ARL +++ WP  + L+P +LA AG Y
Sbjct: 143 PVN-------FRANQDCPALST-SPYHFAMNTEKARLLTYETWP-LSFLSPAKLAKAGFY 193

Query: 295 YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNF 354
           Y G GD+V CF C GKL NWE  D A SEH+RHFP+C F+  ++L   +    VS     
Sbjct: 194 YIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPSCPFL--KDLGQSASRYTVS----- 246

Query: 355 PNSTNLPRNPSMADYEARIFTFGTWIYS--VNKEQLARAGFYALGEGDKVKCFHCGGGLT 412
                   N SM  + ARI TF  W  S  V+ ++LA AGFY  G  D VKCF C GGL 
Sbjct: 247 --------NLSMQTHAARIRTFSNWPSSALVHSQELASAGFYYTGHSDDVKCFCCDGGLR 298

Query: 413 DWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEKTPSLTR-- 468
            W+  +DPW +HAKW+P C+YLL  KGQE+++ +     H LE+ L  +T  +P      
Sbjct: 299 CWESGDDPWVEHAKWFPRCEYLLRIKGQEFVSQVQAGYPHLLEQLL--STSDSPEDENAD 356

Query: 469 -----------RIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVAD 517
                        D  +   P+V+ A+ MGFS   +++ ++ +I  +G NY+++  LV  
Sbjct: 357 AAIVHFGPGESSEDVVMMSTPVVKAALEMGFSRSLVRQTVQRQILATGENYRTVSDLVIG 416

Query: 518 LVNAQKD 524
           L++A+ +
Sbjct: 417 LLDAEDE 423



 Score = 71.2 bits (173), Expect = 6e-11
 Identities = 26/50 (52%), Positives = 37/50 (74%)

Query: 552 KLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           ++CK+CMDR ++IVF+PCGHLV CK CA ++ KCP+C   I    + F+S
Sbjct: 551 RMCKVCMDREVSIVFIPCGHLVVCKDCAPSLRKCPICRGTIKGTVRTFLS 600



>gi|2497240|sp|Q90660|BIR_CHICK   Inhibitor of apoptosis protein (IAP) (Inhibitor of T cell apoptosis
           protein)
 gi|1335774|gb|AAB48118.1|   IAP-like protein [Gallus gallus]
          Length = 611

 Score =  263 bits (672), Expect = 9e-69
 Identities = 164/431 (38%), Positives = 221/431 (51%), Gaps = 61/431 (14%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           +F  E  R+ TF+ FP   PVS   LARAGF YTG  D V+CFSC   +D WQ GD+A+ 
Sbjct: 26  DFSCELYRMSTFSTFPVNVPVSERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAME 85

Query: 186 RHRKVSPNCRFINGFYLENSATQSTNSG-----------------IQNGQYKVENYLGSR 228
           +H++V P+C F+      N+   ST+S                  +     +V  + GS 
Sbjct: 86  KHKQVYPSCSFVQNMLSLNNLGLSTHSAFSPLVASNLSPSLRSMTLSPSFEQVGYFSGSF 145

Query: 229 DHFALDRPSETHADYL--LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPR 286
             F  D  +   A+ L  LR+            +NP+M +EEARL++   WP    L P 
Sbjct: 146 SSFPRDPVTTRAAEDLSHLRSKL----------QNPSMSTEEARLRTSHAWP-LMCLWPA 194

Query: 287 ELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESD 346
           E+A AGL   G  D+V C  CG KL NWEP D A SEHRRHFPNC FV   NL     S 
Sbjct: 195 EVAKAGLDDLGTADKVACVNCGVKLSNWEPKDNAMSEHRRHFPNCPFV--ENLMRDQPSF 252

Query: 347 AVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYALGEGDKVKC 404
            VS             N +M  +EAR+ TF  W     V  EQLA AGFY +G  D VKC
Sbjct: 253 NVS-------------NVTMQTHEARVKTFINWPTRIPVQPEQLADAGFYYVGRNDDVKC 299

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEK 462
           F C GGL  W+  +DPW +HAKW+P C+YLL  KG E+++ +     H L      T++K
Sbjct: 300 FCCDGGLRCWESGDDPWIEHAKWFPRCEYLLRVKGGEFVSQVQARFPHLLWNSSCTTSDK 359

Query: 463 ------------TPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKS 510
                        P  +   D  +   P+V+ A+ MGFS + IK+ ++ KI  +  NYK+
Sbjct: 360 PVDENMDPIIHFEPGESPSEDAIMMNTPVVKAALEMGFSRRLIKQTVQSKILATEENYKT 419

Query: 511 LEVLVADLVNA 521
           +  LV++L+ A
Sbjct: 420 VNDLVSELLTA 430



 Score = 74.3 bits (181), Expect = 8e-12
 Identities = 44/150 (29%), Positives = 75/150 (50%), Gaps = 22/150 (14%)

Query: 452 LEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSL 511
           LE  +++ T +TPS  R + DT+        +I      KD   ++ + + +     KS+
Sbjct: 484 LEHDVIKQTTQTPSQARELIDTVLVKGNAAASIFRN-CLKDFDPVLYKDLFVE----KSM 538

Query: 512 EVLVADLVNAQKDSMQDESSQTSLQKEISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGH 571
           + +  + V+     +  E     LQ+E             + CK+CMD+ ++IVF+PCGH
Sbjct: 539 KYVPTEDVSG----LPMEEQLRRLQEE-------------RTCKVCMDKEVSIVFIPCGH 581

Query: 572 LVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
           LV CK+CA ++ KCP+C   I    + F+S
Sbjct: 582 LVVCKECAPSLRKCPICRGTIKGTVRTFLS 611



>gi|20150096|pdb|1I51|E   Chain E, Crystal Structure Of Caspase-7 Complexed With Xiap
 gi|20150097|pdb|1I51|F   Chain F, Crystal Structure Of Caspase-7 Complexed With Xiap
          Length = 117

 Score =  263 bits (672), Expect = 1e-68
 Identities = 116/117 (99%), Positives = 116/117 (99%)

Query: 228 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE 287
           RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMY EEARLKSFQNWPDYAHLTPRE
Sbjct: 1   RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYCEEARLKSFQNWPDYAHLTPRE 60

Query: 288 LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
Sbjct: 61  LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 117



 Score = 74.3 bits (181), Expect = 7e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 356 NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 413
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 27  SDTIYPRNPAMYCEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKN 86

Query: 414 WKPSEDPWEQHAKWYPGCKYLL 435
           W+P +  W +H + +P C ++L
Sbjct: 87  WEPCDRAWSEHRRHFPNCFFVL 108



 Score = 63.5 bits (153), Expect = 1e-08
 Identities = 30/70 (42%), Positives = 40/70 (57%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  RLK+F N+P  + ++   LA AG  YTG GD V+CF C   +  W+  D A   HR+
Sbjct: 40  EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRR 99

Query: 190 VSPNCRFING 199
             PNC F+ G
Sbjct: 100 HFPNCFFVLG 109



>gi|13096716|pdb|1G3F|A   Chain A, Nmr Structure Of A 9 Residue Peptide From SmacDIABLO
           Complexed To The Bir3 Domain Of Xiap
          Length = 117

 Score =  258 bits (659), Expect = 3e-67
 Identities = 116/116 (100%), Positives = 116/116 (100%)

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
Sbjct: 2   SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 61

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT 460
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
Sbjct: 62  FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT 117



 Score = 75.5 bits (184), Expect = 4e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 254 SDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKN 313
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 13  NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 70

Query: 314 WEPCDRAWSEHRRHFPNCFFVL 335
           W+P +  W +H + +P C ++L
Sbjct: 71  WKPSEDPWEQHAKWYPGCKYLL 92



 Score = 47.4 bits (111), Expect = 0.001
 Identities = 20/52 (38%), Positives = 29/52 (55%)

Query: 146 VSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFI 197
           V+   LARAGF   GEGD V+CF C   +  W+  +    +H K  P C+++
Sbjct: 40  VNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL 91



>gi|13786994|pdb|1I3O|E   Chain E, Crystal Structure Of The Complex Of Xiap-Bir2 And Caspase
           3
 gi|13786995|pdb|1I3O|F   Chain F, Crystal Structure Of The Complex Of Xiap-Bir2 And Caspase
           3
          Length = 121

 Score =  258 bits (659), Expect = 3e-67
 Identities = 115/117 (98%), Positives = 115/117 (98%)

Query: 228 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE 287
           RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE
Sbjct: 5   RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE 64

Query: 288 LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           LASAGLYYTGIGDQVQCF CGGKLKNWEP DRAWSEHRRHFPNCFFVLGRNLNIRSE
Sbjct: 65  LASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 121



 Score = 77.0 bits (188), Expect = 1e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 356 NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 413
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 31  SDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKN 90

Query: 414 WKPSEDPWEQHAKWYPGCKYLL 435
           W+P +  W +H + +P C ++L
Sbjct: 91  WEPGDRAWSEHRRHFPNCFFVL 112



 Score = 68.2 bits (165), Expect = 6e-10
 Identities = 31/70 (44%), Positives = 42/70 (60%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  RLK+F N+P  + ++   LA AG  YTG GD V+CF+C   +  W+ GD A   HR+
Sbjct: 44  EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRR 103

Query: 190 VSPNCRFING 199
             PNC F+ G
Sbjct: 104 HFPNCFFVLG 113



>gi|15826317|pdb|1F9X|A   Chain A, Average Nmr Solution Structure Of The Bir-3 Domain Of Xiap
          Length = 120

 Score =  258 bits (659), Expect = 3e-67
 Identities = 116/116 (100%), Positives = 116/116 (100%)

Query: 345 SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 404
           SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
Sbjct: 5   SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC 64

Query: 405 FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT 460
           FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
Sbjct: 65  FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT 120



 Score = 75.1 bits (183), Expect = 4e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 254 SDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKN 313
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 16  NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 73

Query: 314 WEPCDRAWSEHRRHFPNCFFVL 335
           W+P +  W +H + +P C ++L
Sbjct: 74  WKPSEDPWEQHAKWYPGCKYLL 95



 Score = 47.4 bits (111), Expect = 0.001
 Identities = 20/52 (38%), Positives = 29/52 (55%)

Query: 146 VSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFI 197
           V+   LARAGF   GEGD V+CF C   +  W+  +    +H K  P C+++
Sbjct: 43  VNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL 94



>gi|10120972|pdb|1C9Q|A   Chain A, Average Nmr Solution Structure Of The Bir-2 Domain Of Xiap
          Length = 117

 Score =  258 bits (659), Expect = 3e-67
 Identities = 115/117 (98%), Positives = 115/117 (98%)

Query: 228 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE 287
           RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE
Sbjct: 1   RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRE 60

Query: 288 LASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE 344
           LASAGLYYTGIGDQVQCF CGGKLKNWEP DRAWSEHRRHFPNCFFVLGRNLNIRSE
Sbjct: 61  LASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 117



 Score = 77.0 bits (188), Expect = 1e-12
 Identities = 33/82 (40%), Positives = 49/82 (59%), Gaps = 2/82 (2%)

Query: 356 NSTNLPRNPSMADYEARIFTFGTW--IYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTD 413
           + T  PRNP+M   EAR+ +F  W     +   +LA AG Y  G GD+V+CF CGG L +
Sbjct: 27  SDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKN 86

Query: 414 WKPSEDPWEQHAKWYPGCKYLL 435
           W+P +  W +H + +P C ++L
Sbjct: 87  WEPGDRAWSEHRRHFPNCFFVL 108



 Score = 68.2 bits (165), Expect = 6e-10
 Identities = 31/70 (44%), Positives = 42/70 (60%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  RLK+F N+P  + ++   LA AG  YTG GD V+CF+C   +  W+ GD A   HR+
Sbjct: 40  EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRR 99

Query: 190 VSPNCRFING 199
             PNC F+ G
Sbjct: 100 HFPNCFFVLG 109



>gi|22000680|gb|AAM88215.1|   IAP-like protein [Xenopus laevis]
          Length = 401

 Score =  244 bits (624), Expect = 3e-63
 Identities = 135/379 (35%), Positives = 207/379 (54%), Gaps = 51/379 (13%)

Query: 262 PAMYSEEARLKSFQNWPDYA-HLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRA 320
           P+M SE  RL+SF  WP      +P E+A +G YY G GD+VQCF CGG L++WEP DR 
Sbjct: 35  PSMRSEAERLRSFSAWPRTCPQPSPVEMARSGFYYLGPGDRVQCFSCGGVLRSWEPGDRP 94

Query: 321 WSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNF--------PNSTNLPRNPSMADYEAR 372
            +EHR+ FP+C F+       + + D  ++D           P+ T     P MA+   R
Sbjct: 95  DTEHRKFFPSCTFLQ------QQQRDPGATDSQILGQHSGEEPDRTWESVYPEMAEERDR 148

Query: 373 IFTFGTW-IYSV-NKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPG 430
           + +F  W +Y+  N E LA +GF+  G  D VKCFHC GGL +W+  +DPW +HAKW+P 
Sbjct: 149 LDSFRNWPMYAHGNPEHLAGSGFFYTGHRDNVKCFHCDGGLRNWEQGDDPWTEHAKWFPM 208

Query: 431 CKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP-SLTRRIDD-------------TIFQ 476
           C +LL  KG+ +I  +      +E L R+ E +P SL   I D                Q
Sbjct: 209 CDFLLHVKGEAFIRRV------QESLFRSPESSPDSLGSYIYDRSPASSPGSPESWRYLQ 262

Query: 477 NPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDES-----S 531
           + + Q+A++MGF    +  +++ K  ++GS+Y S+  LV DL+ A++++   ES     +
Sbjct: 263 SSVAQDALQMGFKQSLVASLIQSKFLLTGSSYSSVSDLVTDLLVAEEETHSTESVSVSRA 322

Query: 532 QTSLQKE---------ISTXXXXXXXXXXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAV 582
            T +++          +ST          ++CK+CMD++++++FVPCGHLV C +CA  +
Sbjct: 323 PTRMERSEPPKESAPPLSTEEQLRRLKEERMCKVCMDKDVSMLFVPCGHLVVCTECAPNL 382

Query: 583 DKCPMCYTVITFKQKIFMS 601
             CP+C   I    + FMS
Sbjct: 383 RHCPICRAAIRGSVRAFMS 401



 Score =  134 bits (337), Expect = 7e-30
 Identities = 76/207 (36%), Positives = 101/207 (48%), Gaps = 34/207 (16%)

Query: 130 EFNRLKTFANFPSGSPV-SASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHR 188
           E  RL++F+ +P   P  S   +AR+GF Y G GD V+CFSC   +  W+ GD     HR
Sbjct: 40  EAERLRSFSAWPRTCPQPSPVEMARSGFYYLGPGDRVQCFSCGGVLRSWEPGDRPDTEHR 99

Query: 189 KVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTG 248
           K  P+C F+     +  AT S   G  +G+                 P  T         
Sbjct: 100 KFFPSCTFLQQQQRDPGATDSQILGQHSGE----------------EPDRTW-------- 135

Query: 249 QVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCG 308
                 +++YP    M  E  RL SF+NWP YAH  P  LA +G +YTG  D V+CF C 
Sbjct: 136 ------ESVYPE---MAEERDRLDSFRNWPMYAHGNPEHLAGSGFFYTGHRDNVKCFHCD 186

Query: 309 GKLKNWEPCDRAWSEHRRHFPNCFFVL 335
           G L+NWE  D  W+EH + FP C F+L
Sbjct: 187 GGLRNWEQGDDPWTEHAKWFPMCDFLL 213



 Score = 60.1 bits (144), Expect = 2e-07
 Identities = 28/72 (38%), Positives = 38/72 (52%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           E  EE +RL +F N+P  +  +   LA +GF YTG  D V+CF C   +  W+ GD    
Sbjct: 141 EMAEERDRLDSFRNWPMYAHGNPEHLAGSGFFYTGHRDNVKCFHCDGGLRNWEQGDDPWT 200

Query: 186 RHRKVSPNCRFI 197
            H K  P C F+
Sbjct: 201 EHAKWFPMCDFL 212



>gi|1184314|gb|AAC46988.1|   inhibitor of apoptosis protein
          Length = 498

 Score =  236 bits (603), Expect = 9e-61
 Identities = 155/532 (29%), Positives = 231/532 (43%), Gaps = 108/532 (20%)

Query: 133 RLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSP 192
           RL TF  +P  +PVSA  L   GF  TG+     C  CH  +DRW+YGD    RHR+ SP
Sbjct: 12  RLATFGEWPLNAPVSAEDLVANGFFATGKWLEAECHFCHVRIDRWEYGDQVAERHRRSSP 71

Query: 193 NCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVD 252
            C  +                         N+ G+     + R  E+  +       VVD
Sbjct: 72  ICSMV----------------------LAPNHCGN-----VPRSQESDNE----GNSVVD 100

Query: 253 ISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLK 312
             ++     P +  E  RL +F++WP+  ++TP+ LA AG YY    D V+C  C G + 
Sbjct: 101 SPESC--SCPDLLLEANRLVTFKDWPN-PNITPQALAKAGFYYLNRLDHVKCVWCNGVIA 157

Query: 313 NWEPCDRAWSEHRRHFPNC---------FFVLGRNLNIRSESDAVSSDRNFPNSTNLPRN 363
            WE  D A+ EH+R FP C          F  G+NL           D      T LP  
Sbjct: 158 KWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNL-----------DELGIQPTTLPLR 206

Query: 364 PSMADYEARIFTFGTWIYSVNK--EQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPW 421
           P  A  +AR+ TF  W  S  +    LA+AG Y    GD+V+CFHC  GL  W+  ++PW
Sbjct: 207 PKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPW 266

Query: 422 EQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSL--------------- 466
            +HAKW P C+++L  KG  Y++ +  T +        T   P+L               
Sbjct: 267 FEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSQPATAPAPTLQADVLMDEAPAKEAL 326

Query: 467 TRRIDDTIFQNPMVQEAIRMGFSFKDIKKIME-------------------------EKI 501
           T  ID  + +N + ++ +  G +F  + +++                          E  
Sbjct: 327 TLGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPC 386

Query: 502 QISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEI------------STXXXXXXXX 549
           Q + S   S+ + VAD + A+  + +  ++ + +  EI            S         
Sbjct: 387 QATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLK 446

Query: 550 XXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
             +LCK+C+D  + +VF+PCGHL TC QCA +V  CPMC   I    + F+S
Sbjct: 447 DARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS 498



 Score =  105 bits (261), Expect = 4e-21
 Identities = 65/209 (31%), Positives = 93/209 (44%), Gaps = 44/209 (21%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E NRL TF ++P+ + ++   LA+AGF Y    D V+C  C+  + +W+  D+A   H++
Sbjct: 113 EANRLVTFKDWPNPN-ITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKR 171

Query: 190 VSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQ 249
             P C  +                           +G    FA              TG+
Sbjct: 172 FFPQCPRVQ--------------------------MGPLIEFA--------------TGK 191

Query: 250 VVD---ISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFC 306
            +D   I  T  P  P     +ARL++F +WP         LA AGLYY  IGDQV+CF 
Sbjct: 192 NLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFH 251

Query: 307 CGGKLKNWEPCDRAWSEHRRHFPNCFFVL 335
           C   L++W+  D  W EH +  P C FVL
Sbjct: 252 CNIGLRSWQKEDEPWFEHAKWSPKCQFVL 280



 Score = 91.7 bits (226), Expect = 4e-17
 Identities = 50/171 (29%), Positives = 83/171 (48%), Gaps = 3/171 (1%)

Query: 264 MYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSE 323
           M  E  RL +F  WP  A ++  +L + G + TG   + +C  C  ++  WE  D+    
Sbjct: 6   MELESVRLATFGEWPLNAPVSAEDLVANGFFATGKWLEAECHFCHVRIDRWEYGDQVAER 65

Query: 324 HRRHFPNCFFVLGRNL--NIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIY 381
           HRR  P C  VL  N   N+    ++ +   +  +S      P +     R+ TF  W  
Sbjct: 66  HRRSSPICSMVLAPNHCGNVPRSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWPN 125

Query: 382 -SVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGC 431
            ++  + LA+AGFY L   D VKC  C G +  W+ +++ +E+H +++P C
Sbjct: 126 PNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQC 176



>gi|11991646|gb|AAG42316.1|   apoptosis inhibitor ch-IAP1 [Gallus gallus]
          Length = 324

 Score =  235 bits (600), Expect = 2e-60
 Identities = 137/321 (42%), Positives = 171/321 (53%), Gaps = 47/321 (14%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E  R+ TF+ FP   PVS   LARAGF YTG  D V+CFSC   +D WQ GD+A+ +H++
Sbjct: 30  ELYRMSTFSTFPVNVPVSERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQ 89

Query: 190 VSPNCRFINGFYLENSATQSTNSG-----------------IQNGQYKVENYLGSRDHFA 232
           V P+C F+      N+   ST+S                  +     +V  + GS   F 
Sbjct: 90  VYPSCSFVQNMLSLNNLGLSTHSAFSPLVASNLSPSLRSMTLSPSFEQVGYFSGSFSSFP 149

Query: 233 LDRPSETHADYL--LRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELAS 290
            D  +   A+ L  LR+             NP+M +EEARL++F  WP    L+P ELA 
Sbjct: 150 QDPVTTRAAEDLSHLRSKL----------HNPSMSTEEARLRTFHAWP-LMFLSPTELAK 198

Query: 291 AGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSS 350
           AGLYY G  D+V CF CGG+L NWEP D A SEHRRHFPNC FV   NL     S  VS 
Sbjct: 199 AGLYYLGTADKVACFTCGGQLSNWEPKDNAMSEHRRHFPNCPFV--ENLMRDQPSFNVS- 255

Query: 351 DRNFPNSTNLPRNPSMADYEARIFTFGTWI--YSVNKEQLARAGFYALGEGDKVKCFHCG 408
                       N +M  +EAR+ TF  W     V  EQLA AGFY +G  D VKCF C 
Sbjct: 256 ------------NVTMQTHEARVKTFINWPTRIPVQPEQLADAGFYYVGRNDDVKCFCCD 303

Query: 409 GGLTDWKPSEDPWEQHAKWYP 429
           GGL  W+  +DPW +HAKW+P
Sbjct: 304 GGLRCWESGDDPWIEHAKWFP 324



 Score =  123 bits (308), Expect = 1e-26
 Identities = 76/245 (31%), Positives = 116/245 (47%), Gaps = 46/245 (18%)

Query: 267 EEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRR 326
           E  R+ +F  +P    ++ R LA AG YYTG+ D+V+CF CG  L NW+P D A  +H++
Sbjct: 30  ELYRMSTFSTFPVNVPVSERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQ 89

Query: 327 HFPNCFFV--------------------LGRNLNIRSESDAVS-----------SDRNFP 355
            +P+C FV                    +  NL+    S  +S           S  +FP
Sbjct: 90  VYPSCSFVQNMLSLNNLGLSTHSAFSPLVASNLSPSLRSMTLSPSFEQVGYFSGSFSSFP 149

Query: 356 NSTNLPR-------------NPSMADYEARIFTFGTW-IYSVNKEQLARAGFYALGEGDK 401
                 R             NPSM+  EAR+ TF  W +  ++  +LA+AG Y LG  DK
Sbjct: 150 QDPVTTRAAEDLSHLRSKLHNPSMSTEEARLRTFHAWPLMFLSPTELAKAGLYYLGTADK 209

Query: 402 VKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLE-QKGQEYINNIHLTHSLEECLVRTT 460
           V CF CGG L++W+P ++   +H + +P C ++    + Q   N  ++T    E  V+T 
Sbjct: 210 VACFTCGGQLSNWEPKDNAMSEHRRHFPNCPFVENLMRDQPSFNVSNVTMQTHEARVKTF 269

Query: 461 EKTPS 465
              P+
Sbjct: 270 INWPT 274



 Score = 65.9 bits (159), Expect = 3e-09
 Identities = 40/98 (40%), Positives = 59/98 (60%), Gaps = 7/98 (7%)

Query: 372 RIFTFGTWIYSV--NKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYP 429
           R+ TF T+  +V  ++ +LARAGFY  G  DKVKCF CG  L +W+P ++  E+H + YP
Sbjct: 33  RMSTFSTFPVNVPVSERRLARAGFYYTGVQDKVKCFSCGLVLDNWQPGDNAMEKHKQVYP 92

Query: 430 GCKYLLEQKGQEYINNIHL-THSLEECLVRTTEKTPSL 466
            C ++   +    +NN+ L THS    LV  +  +PSL
Sbjct: 93  SCSFV---QNMLSLNNLGLSTHSAFSPLV-ASNLSPSL 126



>gi|1160518|gb|AAC41610.1|   apoptosis 2 inhibitor
 gi|1586950|prf||2205254B   DIAP2 protein
          Length = 498

 Score =  235 bits (599), Expect = 2e-60
 Identities = 154/532 (28%), Positives = 228/532 (42%), Gaps = 108/532 (20%)

Query: 133 RLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSP 192
           RL TF  +P  +PVSA  L   GF  TG      C  CH  +DRW+YGD    RHR+ SP
Sbjct: 12  RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSP 71

Query: 193 NCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVD 252
            C  +                         N+ G       + P    +D   +   VVD
Sbjct: 72  ICSMV----------------------LAPNHCG-------NVPRSQESDN--KGNSVVD 100

Query: 253 ISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLK 312
             ++     P +  E  RL +F++WP+  ++TP+ LA AG YY    D V+C  C G + 
Sbjct: 101 SPESC--SCPDLLLEANRLVTFKDWPN-PNITPQALAKAGFYYLNRLDHVKCVWCNGVIA 157

Query: 313 NWEPCDRAWSEHRRHFPNC---------FFVLGRNLNIRSESDAVSSDRNFPNSTNLPRN 363
            WE  D A+ EH+R FP C          F  G+NL           D      T LP  
Sbjct: 158 KWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNL-----------DELGIQPTTLPLR 206

Query: 364 PSMADYEARIFTFGTWIYSVNK--EQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPW 421
           P  A  +AR+ TF  W  S  +    LA+AG Y    GD+V+CFHC  GL  W+  ++PW
Sbjct: 207 PKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPW 266

Query: 422 EQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRR------------ 469
            +HAKW P C+++L  KG  Y++ +  T +        T   P+L               
Sbjct: 267 FEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSPPATAPAPTLQADVLMDEAPAKEAL 326

Query: 470 ---IDDTIFQNPMVQEAIRMGFSFKDIKKIME-------------------------EKI 501
              ID  + +N + ++ +  G +F  + +++                          E  
Sbjct: 327 ALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPC 386

Query: 502 QISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEI------------STXXXXXXXX 549
           Q + S   S+ + VAD + A+  + +  ++ + +  EI            S         
Sbjct: 387 QATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLK 446

Query: 550 XXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
             +LCK+C+D  + +VF+PCGHL TC QCA +V  CPMC   I    + F+S
Sbjct: 447 DARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS 498



 Score =  105 bits (261), Expect = 5e-21
 Identities = 65/209 (31%), Positives = 93/209 (44%), Gaps = 44/209 (21%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E NRL TF ++P+ + ++   LA+AGF Y    D V+C  C+  + +W+  D+A   H++
Sbjct: 113 EANRLVTFKDWPNPN-ITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKR 171

Query: 190 VSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQ 249
             P C  +                           +G    FA              TG+
Sbjct: 172 FFPQCPRVQ--------------------------MGPLIEFA--------------TGK 191

Query: 250 VVD---ISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFC 306
            +D   I  T  P  P     +ARL++F +WP         LA AGLYY  IGDQV+CF 
Sbjct: 192 NLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFH 251

Query: 307 CGGKLKNWEPCDRAWSEHRRHFPNCFFVL 335
           C   L++W+  D  W EH +  P C FVL
Sbjct: 252 CNIGLRSWQKEDEPWFEHAKWSPKCQFVL 280



 Score = 91.7 bits (226), Expect = 5e-17
 Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 3/172 (1%)

Query: 263 AMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWS 322
            M  E  RL +F  WP  A ++  +L + G + TG   + +C  C  ++  WE  D+   
Sbjct: 5   GMELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAE 64

Query: 323 EHRRHFPNCFFVLGRNL--NIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI 380
            HRR  P C  VL  N   N+    ++ +   +  +S      P +     R+ TF  W 
Sbjct: 65  RHRRSSPICSMVLAPNHCGNVPRSQESDNKGNSVVDSPESCSCPDLLLEANRLVTFKDWP 124

Query: 381 Y-SVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGC 431
             ++  + LA+AGFY L   D VKC  C G +  W+ +++ +E+H +++P C
Sbjct: 125 NPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQC 176



>gi|15030166|gb|AAH11338.1|   Birc2 protein [Mus musculus]
          Length = 374

 Score =  235 bits (599), Expect = 2e-60
 Identities = 141/354 (39%), Positives = 189/354 (53%), Gaps = 41/354 (11%)

Query: 126 EFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVG 185
           +F  E  RL T++ FP G PVS  +LARAGF YTG  D V+CF C   +D W+ G S + 
Sbjct: 23  DFSCELYRLSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGGSPME 82

Query: 186 RHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKV--------EN---YLGSRDHFALD 234
           +HRK+ P+C F+      NS   S    + +             EN   + GS   F  D
Sbjct: 83  KHRKLYPSCNFVQTLNPANSLEASPRPSLPSTAMSTMPLSFASSENTGYFSGSYSSFPSD 142

Query: 235 RPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLY 294
             +        R  Q      T  P + AM +E+ARL +++ WP  + L+P +LA AG Y
Sbjct: 143 PVN-------FRANQDCPALST-SPYHFAMNTEKARLLTYETWP-LSFLSPAKLAKAGFY 193

Query: 295 YTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNF 354
           Y G GD+V CF C GKL NWE  D A SEH+RHFP+C F+  ++L   +    VS     
Sbjct: 194 YIGPGDRVACFACDGKLSNWERKDDAMSEHQRHFPSCPFL--KDLGQSASRYTVS----- 246

Query: 355 PNSTNLPRNPSMADYEARIFTFGTWIYS--VNKEQLARAGFYALGEGDKVKCFHCGGGLT 412
                   N SM  + ARI TF  W  S  V+ ++LA AGFY  G  D VKCF C GGL 
Sbjct: 247 --------NLSMQTHAARIRTFSNWPSSALVHSQELASAGFYYTGHSDDVKCFCCDGGLR 298

Query: 413 DWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIH--LTHSLEECLVRTTEKTP 464
            W+  +DPW +HAKW+P C+YLL  KGQE+++ +     H LE+ L  +T  +P
Sbjct: 299 CWESGDDPWVEHAKWFPRCEYLLRIKGQEFVSQVQAGYPHLLEQLL--STSDSP 350



>gi|2497244|sp|Q24307|IAP2_DROME   Apoptosis 2 inhibitor (Inhibitor of apoptosis 2) (dIAP2) (DIAP)
           (IAP homolog A) (IAP-like protein) (DILP)
          Length = 498

 Score =  234 bits (598), Expect = 4e-60
 Identities = 154/532 (28%), Positives = 229/532 (43%), Gaps = 108/532 (20%)

Query: 133 RLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSP 192
           RL TF  +P  +PVSA  L   GF  TG      C  CH  +DRW+YGD    RHR+ SP
Sbjct: 12  RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSP 71

Query: 193 NCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVD 252
            C  +                         N+ G+     + R  E+  +       VVD
Sbjct: 72  ICSMV----------------------LAPNHCGN-----VPRSQESDNE----GNSVVD 100

Query: 253 ISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLK 312
             ++     P +  E  RL +F++WP+  ++TP+ LA AG YY    D V+C  C G + 
Sbjct: 101 SPESC--SCPDLLLEANRLVTFKDWPN-PNITPQALAKAGFYYLNRLDHVKCVWCNGVIA 157

Query: 313 NWEPCDRAWSEHRRHFPNC---------FFVLGRNLNIRSESDAVSSDRNFPNSTNLPRN 363
            WE  D A+ EH+R FP C          F  G+NL           D      T LP  
Sbjct: 158 KWEKNDNAFEEHKRFFPQCPRVQMGPLIEFATGKNL-----------DELGIQPTTLPLR 206

Query: 364 PSMADYEARIFTFGTWIYSVNK--EQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPW 421
           P  A  +AR+ TF  W  S  +    LA+AG Y    GD+V+CFHC  GL  W+  ++PW
Sbjct: 207 PKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPW 266

Query: 422 EQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRR------------ 469
            +HAKW P C+++L  KG  Y++ +  T +        T   P+L               
Sbjct: 267 FEHAKWSPKCQFVLLAKGPAYVSEVLATTAANASSPPATAPAPTLQADVLMDEAPAKEAL 326

Query: 470 ---IDDTIFQNPMVQEAIRMGFSFKDIKKIME-------------------------EKI 501
              ID  + +N + ++ +  G +F  + +++                          E  
Sbjct: 327 ALGIDGGVVRNAIQRKLLSSGCAFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPC 386

Query: 502 QISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEI------------STXXXXXXXX 549
           Q + S   S+ + VAD + A+  + +  ++ + +  EI            S         
Sbjct: 387 QATTSKAASVPIPVADSIPAKPQAAEAVANISKITDEIQKMSVATPNGNLSLEEENRQLK 446

Query: 550 XXKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 601
             +LCK+C+D  + +VF+PCGHL TC QCA +V  CPMC   I    + F+S
Sbjct: 447 DARLCKVCLDEEVGVVFLPCGHLATCNQCAPSVANCPMCRADIKGFVRTFLS 498



 Score =  105 bits (261), Expect = 4e-21
 Identities = 65/209 (31%), Positives = 93/209 (44%), Gaps = 44/209 (21%)

Query: 130 EFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRK 189
           E NRL TF ++P+ + ++   LA+AGF Y    D V+C  C+  + +W+  D+A   H++
Sbjct: 113 EANRLVTFKDWPNPN-ITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKR 171

Query: 190 VSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQ 249
             P C  +                           +G    FA              TG+
Sbjct: 172 FFPQCPRVQ--------------------------MGPLIEFA--------------TGK 191

Query: 250 VVD---ISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFC 306
            +D   I  T  P  P     +ARL++F +WP         LA AGLYY  IGDQV+CF 
Sbjct: 192 NLDELGIQPTTLPLRPKYACVDARLRTFTDWPISNIQPASALAQAGLYYQKIGDQVRCFH 251

Query: 307 CGGKLKNWEPCDRAWSEHRRHFPNCFFVL 335
           C   L++W+  D  W EH +  P C FVL
Sbjct: 252 CNIGLRSWQKEDEPWFEHAKWSPKCQFVL 280



 Score = 91.7 bits (226), Expect = 5e-17
 Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 3/172 (1%)

Query: 263 AMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWS 322
            M  E  RL +F  WP  A ++  +L + G + TG   + +C  C  ++  WE  D+   
Sbjct: 5   GMELESVRLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAE 64

Query: 323 EHRRHFPNCFFVLGRNL--NIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI 380
            HRR  P C  VL  N   N+    ++ +   +  +S      P +     R+ TF  W 
Sbjct: 65  RHRRSSPICSMVLAPNHCGNVPRSQESDNEGNSVVDSPESCSCPDLLLEANRLVTFKDWP 124

Query: 381 Y-SVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGC 431
             ++  + LA+AGFY L   D VKC  C G +  W+ +++ +E+H +++P C
Sbjct: 125 NPNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAFEEHKRFFPQC 176






  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF
    Posted date:  Mar 9, 2004  2:01 PM
  Number of letters in database: 748,330,716
  Number of sequences in database:  2,678,069
  
Lambda     K      H
   0.319    0.134    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 175,576,866
Number of Sequences: 2678069
Number of extensions: 7518490
Number of successful extensions: 17035
Number of sequences better than 10.0: 134
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 16608
Number of HSP's gapped (non-prelim): 300
length of query: 601
length of database: 748,330,716
effective HSP length: 132
effective length of query: 469
effective length of database: 394,825,608
effective search space: 185173210152
effective search space used: 185173210152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 77 (34.3 bits)