NCBI Conserved Domain Search
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RPS-BLAST 2.2.8 [Jan-05-2004]

Query= local sequence:
hg16_dna_4|geneid_v1.1_predicted_protein_4|
         (391 letters)

Database: cdd.v1.65
           18,039 PSSMs; 5,506,404 total columns
gnl|CDD|18532 KOG0738, KOG0738, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18532 KOG0738, KOG0738, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18533 KOG0739, KOG0739, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18534 KOG0740, KOG0740, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18531 KOG0737, KOG0737, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18524 KOG0730, KOG0730, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18524 KOG0730, KOG0730, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones]gnl|CDD|10337 COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]gnl|CDD|10337 COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]gnl|CDD|10940 COG1222, RPT1, ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18530 KOG0736, KOG0736, Peroxisome assembly factor 2 containing the AAA+-type ATPase domain [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18530 KOG0736, KOG0736, Peroxisome assembly factor 2 containing the AAA+-type ATPase domain [Posttranslational modification, protein turnover, chaperones]gnl|CDD|18527 KOG0733, KOG0733, Nuclear AAA ATPase (VCP subfamily) [Posttranslational modification, protein turnover, chaperones]
 Domain Relatives
    .. This CD alignment includes 3D structure. To display structure, download Cn3D!
  PSSMs producing significant alignments: Score
(bits)		 E
value
 
  gnl|CDD|18532 KOG0738, KOG0738, AAA+-type ATPase [Posttranslational modifica... 505 7e-144
  gnl|CDD|18532 KOG0738, KOG0738, AAA+-type ATPase [Posttranslational modifica... 145 2e-35
  gnl|CDD|18533 KOG0739, KOG0739, AAA+-type ATPase [Posttranslational modifica... 278 2e-75
  gnl|CDD|18534 KOG0740, KOG0740, AAA+-type ATPase [Posttranslational modifica... 258 2e-69
  gnl|CDD|18531 KOG0737, KOG0737, AAA+-type ATPase [Posttranslational modifica... 238 2e-63
  gnl|CDD|18524 KOG0730, KOG0730, AAA+-type ATPase [Posttranslational modifica... 237 5e-63
  gnl|CDD|18524 KOG0730, KOG0730, AAA+-type ATPase [Posttranslational modifica... 166 1e-41
  gnl|CDD|10337 COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational m... 226 6e-60
  gnl|CDD|10337 COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational m... 117 4e-27
  gnl|CDD|10940 COG1222, RPT1, ATP-dependent 26S proteasome regulatory subunit... 220 4e-58
  gnl|CDD|18530 KOG0736, KOG0736, Peroxisome assembly factor 2 containing the ... 220 5e-58
  gnl|CDD|18530 KOG0736, KOG0736, Peroxisome assembly factor 2 containing the ... 89.7 1e-18
  gnl|CDD|18527 KOG0733, KOG0733, Nuclear AAA ATPase (VCP subfamily) [Posttran... 212 8e-56
  gnl|CDD|18527 KOG0733, KOG0733, Nuclear AAA ATPase (VCP subfamily) [Posttran... 170 4e-43
gnl|CDD|25355 pfam00004, AAA, ATPase family associated with various cellular... 199 7e-52
  gnl|CDD|18529 KOG0735, KOG0735, AAA+-type ATPase [Posttranslational modifica... 176 9e-45
  gnl|CDD|18529 KOG0735, KOG0735, AAA+-type ATPase [Posttranslational modifica... 58.5 3e-09
  gnl|CDD|18522 KOG0728, KOG0728, 26S proteasome regulatory complex, ATPase RP... 176 1e-44
  gnl|CDD|18525 KOG0731, KOG0731, AAA+-type ATPase containing the peptidase M4... 176 1e-44
  gnl|CDD|18446 KOG0652, KOG0652, 26S proteasome regulatory complex, ATPase RP... 169 1e-42
  gnl|CDD|18528 KOG0734, KOG0734, AAA+-type ATPase containing the peptidase M4... 168 2e-42
  gnl|CDD|18520 KOG0726, KOG0726, 26S proteasome regulatory complex, ATPase RP... 162 1e-40
  gnl|CDD|10338 COG0465, HflB, ATP-dependent Zn proteases [Posttranslational m... 161 3e-40
  gnl|CDD|18521 KOG0727, KOG0727, 26S proteasome regulatory complex, ATPase RP... 157 4e-39
  gnl|CDD|18523 KOG0729, KOG0729, 26S proteasome regulatory complex, ATPase RP... 153 6e-38

gnl|CDD|18532, KOG0738, KOG0738, KOG0738, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 491 residues, only  58.0% aligned
             Score =  505 bits (1302), Expect = 7e-144

Query:  104  PAEHRDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVA  163
Sbjct:  207  PNIKWDDIAGLHEAKKLLKEAVVLPIWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVA  266

Query:  164  TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH  223
Sbjct:  267  TECGTTFFNVSSSTLTSKWRGESEKLVRLLFEMARFYAPSTIFIDEIDSLCSQRGGSSEH  326

Query:  224  EASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPT  283
Sbjct:  327  EASRRVKSELLVQMDGVQGTLEN---SKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPD  383

Query:  284  AKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPE  343
Sbjct:  384  AEARSALIKILLRSVELDDPVNLEDLAERSEGYSGADITNVCREASMMAMRRKIAGLTPR  443

Query:  344  EIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGSA  391
Sbjct:  444  EIRQLAKEEPKMPVTNEDFEEALRKVRPSVSAADLEKYEKWMDEFGSC  491
gnl|CDD|18532, KOG0738, KOG0738, KOG0738, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 491 residues, only  22.0% aligned
             Score =  145 bits (366), Expect = 2e-35

Query:  1    MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELL  60
Sbjct:  1    MSLAGISENAKLAREYALLGNYDSAGIYYRGLLYLMNRYLVSTGDPYAQGKWSQVEQALT  60

Query:  61   EEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHR  108
Sbjct:  61   EEYELVKQIVRDLRDLKEASTPTLKFSGHDEPPIDPDVWAKPKPVERR  108
gnl|CDD|18533, KOG0739, KOG0739, KOG0739, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 439 residues, only  69.2% aligned
             Score =  278 bits (712), Expect = 2e-75

Query:  109  DDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGT  168
Sbjct:  133  SDVAGLEGAKEALKEAVILPIKFPQLFTGKRKPWRGILLYGPPGTGKSYLAKAVATEANS  192

Query:  169  TFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRR  228
Sbjct:  193  TFFSVSSSDLVSKWMGESEKLVKNLFEMARENKPSIIFIDEIDSLCGSRS-ENESEASRR  251

Query:  229  VKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRA  288
Sbjct:  252  IKTEFLVQMQGVG----NDNDG--VLVLGATNIPWVLDSAIRRRFEKRIYIPLPEAHARA  305

Query:  289  ELLKINLREVE---LDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRI--------  337
Sbjct:  306  RMFKLHLGDTPHVLTEQDF--KELARKTEGYSGSDISIVVRDA-LMEPVRKVQSATHFKK  362

Query:  338  --NGLSPEEIRAL--------------------SKEELQMPVTKGDFELALKKIAKSVSA  375
Sbjct:  363  VSGPSNPSEVDDLLTPCSPGDPGAIEMSWMDVPADKLLEPPVTMRDFLKSLSRTKPTVNE  422

Query:  376  ADLEKYEKWMVEFG  389
Sbjct:  423  DDLLKHEKFTEDFG  436
gnl|CDD|18534, KOG0740, KOG0740, KOG0740, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 428 residues, only  65.2% aligned
             Score =  258 bits (660), Expect = 2e-69

Query:  104  PAEHRDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVA  163
Sbjct:  148  RNVGWDDIAGLEDAKQSLKEAVILPLLRPDLFLGLREPVRGLLLFGPPGTGKTMLAKAIA  207

Query:  164  TECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEH  223
Sbjct:  208  TESGATFFNISASSLTSKYVGESEKLVRALFKVARSLQPSVIFIDEIDSLLSKRSDN-EH  266

Query:  224  EASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPT  283
Sbjct:  267  ESSRRLKTEFLLQFDGK-----NSAPDDRVLVIGATNRPWELDEAARRRFVKRLYIPLPD  321

Query:  284  AKGRAELLKINLREVELDPDI----QLEDIAEKIEGYSGADITNVCRDASLMAMRRRING  339
Sbjct:  322  YETRSLLWK---QLLKEQPNGLSDLDISLLAKVTEGYSGSDITALCKEAAMGPLRELGGT  378

Query:  340  LSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGSA  391
Sbjct:  379  TDLEFIDADKI----RPITYPDFKNAFKNIKPSVSLEGLEKYEKWDKEFGSS  426
gnl|CDD|18531, KOG0737, KOG0737, KOG0737, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 386 residues, only  71.0% aligned
             Score =  238 bits (609), Expect = 2e-63

Query:  109  DDIADLEEAKKLLREAVVLPMWMPDFFKGIR--RPWKGVLMVGPPGTGKTMLAKAVATEC  166
Sbjct:  92   DDIGGLEEVKDALQELVILPLRRPELFAKGKLLRPPKGILLYGPPGTGKTMLAKAIAKEA  151

Query:  167  GTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEAS  226
Sbjct:  152  GANFINVSVSNLTSKWFGEAQKLVKAVFSLASKLQPSIIFIDEVDSFLGQRRSTD-HEAT  210

Query:  227  RRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKG  286
Sbjct:  211  AMMKNEFMALWDGL-----SSKDSERVLVLGATNRPFDLDEAIIRRLPRRFHVGLPDAEQ  265

Query:  287  RAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRIN-GLSPEEI  345
Sbjct:  266  RRKILKVILKKEKLEDDVDLDEIAQMTEGYSGSDLKELCRLAALRPIRELLVSETGLLDL  325

Query:  346  RALSKEELQMPVTKG----------DFELALKKIAKSVSA  375
Sbjct:  326  DKAIADLKPTQAAASSCLLRPLEQEDFPKAINRVSASVAM  365
gnl|CDD|18524, KOG0730, KOG0730, KOG0730, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 693 residues, only  38.0% aligned
             Score =  237 bits (605), Expect = 5e-63

Query:  102  PVPAEHRDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLA  159
Sbjct:  427  EMPNVSWDDIGGLEELKRELQQAVEWPLKHPEKFARFGISPP-KGVLLYGPPGCGKTLLA  485

Query:  160  KAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGT  219
Sbjct:  486  KALANEAGMNFLSVKGPELFSKYVGESERAIREVFRKARQVAPCIIFFDEIDALAGSRG-  544

Query:  220  SDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRI  277
Sbjct:  545  GSSSGVTDRVLSQLLTEMDGLEA-------LKNVLVIAATNRPDMIDPALLRPGRLDRII  597

Query:  278  YIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRI  337
Sbjct:  598  YVPLPDLEARLEILKQCAKKMPFSEDVDLEELAQATEGYSGAEIVAVCQEAALLALRESI  657

Query:  338  NGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW  384
Sbjct:  658  E--ATE-------------ITWQHFEEALKAVRPSLTSELLEKYEDF  689
gnl|CDD|18524, KOG0730, KOG0730, KOG0730, AAA+-type ATPase [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 693 residues, only  38.2% aligned
             Score =  166 bits (421), Expect = 1e-41

Query:  95   DPAVWPPPVPAEHRDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPW-KGVLMVGPPGT  153
Sbjct:  170  EPAKREEEELPEVGDDIGGLKRQLSVIRELVELPLRHPALFKSIGIKPPRGLLLYGPPGT  229

Query:  154  GKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR-FYAPTTIFIDEIDS  212
Sbjct:  230  GKTFLVRAVANEYGAFLFLINGPELISKFPGETESNLRKAFAEALKFQVPSIIFIDELDA  289

Query:  213  ICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR-  271
Sbjct:  290  LCPKREGADDVE--SRVVSQLLTLLDGLKPDAK-------VIVLAATNRPDSLDPALRRG  340

Query:  272  RLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLM  331
Sbjct:  341  RFDREVEIGIPGSDGRLDILRVLTKKMNLLSDVDLEDIAVSTHGYVGADLAALCREASLQ  400

Query:  332  AMRRRINGLSPEE--IRALSKEELQMPVTKGDFE  363
Sbjct:  401  ATRRTLEIFQEALMGIRPSALREILVEMPNVSWD  434
gnl|CDD|10337, COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 494 residues, only  52.4% aligned
             Score =  226 bits (578), Expect = 6e-60

Query:  101  PPVPAEHRDDIADLEEAKKLLREAVVLPMWMPDFFKGI-RRPWKGVLMVGPPGTGKTMLA  159
Sbjct:  234  FEDEDVTLDDIGGLEEAKEELKEAIETPLKRPELFRKLGLRPPKGVLLYGPPGTGKTLLA  293

Query:  160  KAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGT  219
Sbjct:  294  KAVALESRSRFISVKGSELLSKWVGESEKNIRELFEKARKLAPSIIFIDEIDSLASGRGP  353

Query:  220  SDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRI  277
Sbjct:  354  S-EDGSGRRVVGQLLTELDGI-------EKAEGVLVIAATNRPDDLDPALLRPGRFDRLI  405

Query:  278  YIPLPTAKGRAELLKINLREVE--LDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRR  335
Sbjct:  406  YVPLPDLEERLEIFKIHLRDKKPPLAEDVDLEELAEITEGYSGADIAALVREAALEALR-  464

Query:  336  RINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKW  384
Sbjct:  465  ---------------EARRREVTLDDFLDALKKIKPSVT------YEEW  492
gnl|CDD|10337, COG0464, SpoVK, ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 494 residues, only  46.4% aligned
             Score =  117 bits (294), Expect = 4e-27

Query:  126  VLPMWMPD-FFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRG  184
Sbjct:  1    ELPLKEPELFKKLGIEPPKGVLLHGPPGTGKTLLARALA-NEGAEFLSINGPEILSKYVG  59

Query:  185  ESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGAL  244
Sbjct:  60   ESELRLRELFEEAEKLAPSIIFIDEIDALAPKR-SSDQGEVERRVVAQLLALMDGLKRGQ  118

Query:  245  ENDDPSKMVMVLAATNFPWDIDEALRR--RLEKRIYIPLPTAKGRAELLKINLREVELDP  302
Sbjct:  119  --------VIVIGATNRPDGLDPAKRRPGRFDREIEVNLPDEAGRLEILQIHTRLMFLGP  170

Query:  303  DIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDF  362
Sbjct:  171  PGTGKTLAARTVGKSGADLGALAKEAALRE-LRRAIDLVGEYIG----------VTEDDF  219

Query:  363  ELALKKIAKS  372
Sbjct:  220  EEALKKVLPS  229
gnl|CDD|10940, COG1222, RPT1, ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 406 residues, only  61.3% aligned
             Score =  220 bits (563), Expect = 4e-58

Query:  104  PAEHRDDIADLEEAKKLLREAVVLPMWMPDFFK--GIRRPWKGVLMVGPPGTGKTMLAKA  161
Sbjct:  146  PDVTYEDIGGLDEQIQEIREVVELPLKNPELFEELGIDPP-KGVLLYGPPGTGKTLLAKA  204

Query:  162  VATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRR---G  218
Sbjct:  205  VANQTDATFIRVVGSELVQKYIGEGARLVRELFELAREKAPSIIFIDEIDAIGAKRFDSG  264

Query:  219  TSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RLEKR  276
Sbjct:  265  TSGDREV-QRTMLELLNQLDGF-------DPRGNVKVIMATNRPDILDPALLRPGRFDRK  316

Query:  277  IYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRR  336
Sbjct:  317  IEFPLPDEEGRAEILKIHTRKMNLADDVDLELLARLTEGFSGADLKAICTEAGMFAIRER  376

Query:  337  INGLSPEEIRALSKEELQMPVTKGDFELALKKIAK  371
Sbjct:  377  -----------------RDEVTMEDFLKAVEKVVK  394
gnl|CDD|18530, KOG0736, KOG0736, KOG0736, Peroxisome assembly factor 2 containing the AAA+-type ATPase domain [Posttranslational modification, protein turnover, chaperones] 
             CD-Length = 953 residues, only  30.0% aligned
             Score =  220 bits (562), Expect = 5e-58

Query:  97   AVWPPPVPAEHRDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKT  156
Sbjct:  660  AIGAPKIPNVSWDDVGGLEEVKTEILDTIQLPLKHPELFSSGLRKRSGILLYGPPGTGKT  719

Query:  157  MLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSR  216
Sbjct:  720  LLAKAVATECSLNFLSVKGPELLNMYVGQSEENVREVFERARSAAPCVIFFDELDSLAPN  779

Query:  217  RGTS-DEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRR--RL  273
Sbjct:  780  RGRSGDSGGVMDRVVSQLLAELDGL-----SDSSSQDVFVIGATNRPDLLDPALLRPGRF  834

Query:  274  EKRIYIPLP-TAKGRAELLKINLREVELDPDIQLEDIAEKI-EGYSGADITNVCRDASLM  331
Sbjct:  835  DKLVYVGPNEDAESKLRVLEALTRKFKLDEDVDLVEIAKKCPPNMTGADLYSLCSDAMLA  894

Query:  332  AMRRRINGLSPEEIRALSKEELQM