GRAPHICAL RESULTS.

Sequence NM_000567.1:chr1

G

A

G

G

G

A

A

C

A

G

G

A

G

A

T

G

G

A

A

A

A

T

A

G

A

G

G

T

T

G

T

C

A

A

C

C

C

A

C

G

T

A

A

A

C

T

T

T

T

C

C

T

T

C

C

T

T

C

C

T

C

C

C

T

C

T

C

T

C

C

C

T

C

C

C

A

T

C

C

T

T

C

C

T

T

T

T

T

T

C

T

C

T

T

T

T

C

T

T

T

C

T

T

C

T

T

T

C

T

C

T

A

A

A

A

G

A

T

T

A

A

A

T

A

T

A

T

T

A

T

A

G

T

A

T

G

G

T

T

T

T

G

T

G

G

A

A

A

T

G

A

T

C

A

A

G

T

A

A

A

G

A

T

G

A

A

T

A

A

A

T

T

A

A

T

A

A

T

A

C

A

G

A

A

G

A

T

A

G

A

G

A

G

G

A

T

A

C

C

T

A

T

A

G

G

A

G

C

A

A

A

A

T

T

C

C

T

T

G

C

A

T

A

G

T

C

G

A

C

A

G

G

G

T

C

T

G

G

G

A

T

C

C

A

C

T

G

A

A

G

A

A

T

T

G

C

A

A

G

G

G

T

T

G

G

C

C

T

T

A

G

A

T

G

T

A

A

C

A

C

A

G

G

G

A

G

A

G

C

T

C

A

T

C

C

C

T

T

T

T

A

A

T

A

G

A

G

G

A

A

G

A

C

A

G

A

A

A

G

G

C

T

G

G

T

A

C

A

T

T

G

G

G

T

T

G

T

A

G

G

A

G

G

A

T

A

T

A

T

A

A

G

G

A

T

A

T

C

A

G

T

T

A

G

G

T

G

T

T

A

A

G

A

A

C

A

G

A

A

A

G

A

C

T

G

A

G

T

T

A

A

C

A

G

T

G

A

T

T

T

A

A

C

A

A

A

A

G

A

G

G

A

G

A

G

T

A

T

T

T

C

T

C

C

T

T

T

A

A

G

T

A

A

A

T

T

T

T

C

A

G

G

T

A

G

G

C

A

G

C

C

T

A

G

A

G

C

T

G

A

T

G

C

A

G

T

G

G

C

T

C

C

A

T

A

C

C

C

A

A

T

T

A

T

C

C

A

G

G

C

T

C

C

A

T

C

T

A

T

C

T

T

G

T

T

G

C

C

A

T

G

C

C

A

A

C

C

T

C

A

A

C

A

T

G

C

A

G

C

T

T

A

C

A

C

T

T

G

C

T

G

G

C

C

T

G

A

A

A

G

T

G

A

A

C

T

A

T

T

C

C

A

T

C

T

C

C

T

G

C

T

A

T

C

A

T

G

A

C

T

G

A

A

T

A

C

T

A

G

T

C

A

A

A

G

G

G

A

A

A

A

A

G

G

G

G

G

A

A

G

T

G

G

G

A

G

G

G

G

A

A

A

G

C

A

C

A

T

A

C

C

T

T

T

C

T

T

A

A

A

G

A

G

C

A

C

A

A

C

C

T

A

G

A

G

A

T

G

G

T

C

C

C

T

A

T

T

C

T

G

T

T

C

A

T

A

T

C

T

C

G

T

T

G

G

C

C

T

T

A

A

T

T

T

A

A

T

C

A

C

A

T

C

A

T

C

A

C

T

G

C

A

A

G

C

T

A

C

A

G

T

G

G

G

G

G

C

T

G

G

G

A

A

A

T

T

T

G

G

T

G

T

T

T

G

A

G

G

G

G

A

T

G

A

C

C

A

A

G

C

G

C

C

C

A

A

C

T

G

A

A

A

A

T

G

T

T

A

T

T

C

T

T

C

T

C

T

T

A

T

G

A

G

A

A

G

T

A

G

A

G

A

A

T

G

G

A

T

G

T

T

A

G

G

G

A

A

T

G

G

C

T

A

G

A

A

G

A

C

T

C

T

A

C

T

A

C

A

A

A

G

G

A

T

A

C

G

G

T

G

G

T

T

C

T

T

T

T

C

T

G

A

T

T

G

C

T

T

C

T

A

A

C

T

T

C

T

C

A

A

T

G

A

A

A

G

G

T

G

A

G

T

T

C

A

T

C

A

G

C

T

G

A

A

T

G

A

A

A

G

A

A

T

A

A

A

T

G

A

G

A

T

T

T

T

G

G

G

G

A

C

T

T

G

A

G

G

A

G

C

A

A

G

G

A

G

A

A

G

G

A

G

T

A

T

A

A

T

A

G

T

C

A

T

T

T

T

G

A

A

G

A

G

T

G

A

G

T

T

A

A

G

T

A

G

G

G

A

A

C

T

G

T

A

G

T

A

A

G

A

T

T

G

A

C

A

G

A

C

A

G

T

G

T

G

G

A

G

G

G

A

T

T

A

C

T

T

G

A

A

T

C

T

T

G

T

G

A

A

T

A

G

A

G

G

A

A

A

G

A

G

T

A

G

A

A

T

C

A

G

A

T

T

A

T

C

C

T

G

A

C

T

C

C

T

G

C

C

T

G

A

A

G

C

T

T

T

A

C

A

T

A

T

T

C

A

G

A

G

A

A

A

A

A

T

G

T

T

G

G

A

A

G

A

A

A

C

T

T

T

G

A

T

A

T

A

A

T

G

C

T

A

T

G

T

C

T

G

T

G

A

T

C

A

G

G

C

A

C

A

C

A

T

T

T

T

A

C

T

G

G

A

C

T

T

T

T

A

C

T

G

T

C

A

G

G

G

C

C

G

T

C

A

T

T

T

A

G

T

G

C

C

A

A

G

A

T

G

T

C

T

A

G

A

G

A

G

T

T

C

T

T

A

A

T

A

A

G

T

G

T

A

C

T

C

A

A

T

T

G

G

C

T

G

A

G

A

A

A

A

T

G

T

G

T

C

C

A

T

G

C

A

A

A

A

A

A

C

C

A

A

A

C

A

C

C

G

C

G

T

G

T

T

C

T

C

A

C

T

C

A

T

A

G

A

T

G

G

G

A

A

T

T

G

A

A

C

A

A

T

G

A

G

A

A

T

A

C

T

T

G

G

A

C

A

C

A

G

G

A

A

G

G

G

G

A

A

C

A

T

C

A

C

A

C

T

C

T

G

G

G

G

A

C

T

G

T

T

G

T

G

G

G

G

T

G

G

G

G

G

G

A

G

G

G

G

G

G

A

G

G

G

A

T

A

G

C

A

T

T

A

G

A

A

G

A

T

A

T

A

C

C

T

A

A

T

G

C

T

A

A

A

T

G

A

T

G

A

G

T

T

A

A

T

G

G

G

T

G

C

A

G

C

A

C

A

C

C

A

G

C

A

T

G

G

C

A

C

A

T

G

T

A

T

A

C

A

T

A

T

G

T

A

A

C

T

A

A

C

C

T

G

C

A

C

A

T

T

G

T

G

C

A

C

A

T

G

T

A

C

C

C

T

A

A

A

A

C

T

T

A

A

A

G

T

A

T

A

A

T

A

A

T

A

A

T

A

A

A

A

A

A

A

T

G

T

G

T

C

C

A

T

G

G

C

T

C

T

G

G

G

A

G

G

A

G

C

A

T

G

T

T

T

G

T

T

T

T

C

C

T

C

A

T

T

T

C

C

C

A

G

T

C

T

G

T

A

A

A

T

A

A

G

C

A

A

A

T

T

G

A

A

A

G

G

G

G

T

T

A

G

T

G

A

T

A

A

T

G

T

C

C

A

T

C

T

C

C

A

G

A

A

G

C

T

G

T

C

A

G

A

T

T

T

C

C

T

T

T

G

T

C

A

A

A

C

T

C

T

A

T

G

A

T

T

T

G

G

G

C

T

G

A

A

G

T

A

G

G

T

G

T

T

G

G

A

G

A

G

G

C

A

G

C

T

A

C

C

A

C

G

T

G

C

A

C

C

C

A

G

A

T

G

G

C

C

A

C

T

C

G

T

T

T

A

A

T

A

T

G

T

T

A

C

C

A

T

T

T

C

C

C

A

T

T

A

T

T

T

T

C

G

C

A

G

G

A

T

A

G

A

T

A

G

C

C

A

A

A

G

T

G

G

A

G

C

C

C

T

G

A

G

A

G

A

T

T

T

C

T

T

C

A

T

T

T

T

T

C

C

T

G

T

C

A

T

A

A

A

G

A

A

T

T

G

G

T

A

A

T

T

C

A

G

T

A

G

T

C

A

T

A

G

G

A

G

T

T

T

G

T

A

A

T

A

A

A

T

A

A

C

T

C

A

C

A

T

T

G

A

T

T

T

C

T

C

T

G

T

T

C

T

G

A

A

A

T

A

A

T

T

T

T

G

C

T

T

C

C

C

C

T

C

T

T

C

C

C

G

A

A

G

C

T

C

T

G

A

C

A

C

C

T

G

C

C

C

C

A

A

C

A

A

G

C

A

A

T

G

T

T

G

G

A

A

A

A

T

T

A

T

T

T

A

C

A

T

A

G

T

G

G

C

G

C

A

A

A

C

T

C

C

C

T

T

A

C

T

G

C

T

T

T

G

G

A

T

A

T

A

A

A

T

C

C

A

G

G

C

A

G

G

A

G

G

A

G

G

T

A

G

C

T

C

T

A

A

G

G

C

A

A

G

A

G

A

T

C

T

A

Matrix 1

Matrix 2

Sequence NM_000277.1:chr12

G

G

T

A

G

T

A

G

G

G

G

C

C

T

G

G

A

G

G

G

G

A

G

G

T

G

G

A

G

A

T

G

G

T

T

A

A

T

A

G

G

T

A

C

A

A

A

A

A

A

A

T

A

T

A

G

A

A

A

G

A

A

T

G

A

A

T

A

A

G

A

C

C

T

A

G

T

A

T

T

T

G

A

T

A

G

T

A

C

A

A

C

A

G

G

G

C

G

A

A

T

A

T

A

G

T

C

A

A

A

A

T

A

A

T

T

T

A

A

T

T

A

T

A

C

A

T

T

T

A

A

A

A

A

T

A

C

C

T

G

A

A

A

G

A

G

T

A

T

A

A

T

T

G

G

C

T

T

G

T

T

T

G

C

A

A

C

A

C

A

A

A

A

G

A

T

A

A

A

T

G

C

T

T

G

A

G

G

G

G

A

T

G

G

A

T

G

C

C

C

C

A

T

T

T

T

C

A

A

T

G

A

T

G

T

G

A

T

T

A

T

T

A

C

A

C

A

T

T

G

C

A

T

G

C

C

T

G

T

A

T

C

A

A

A

A

T

A

T

T

G

C

A

C

A

T

A

C

T

C

C

A

T

G

A

A

T

G

C

A

T

A

C

A

T

C

T

A

C

T

A

T

G

T

T

C

C

C

A

C

A

A

A

A

A

T

T

A

A

A

C

A

T

T

A

G

A

A

A

A

A

A

G

A

G

T

T

G

C

A

T

T

T

T

C

A

G

C

T

G

T

T

A

T

G

G

G

G

A

G

A

A

G

A

A

A

G

A

A

A

A

G

C

T

A

T

C

A

T

T

T

T

G

T

T

G

T

C

C

T

A

A

A

A

A

T

T

A

T

G

T

T

G

T

C

C

T

C

A

T

T

T

C

A

A

A

C

A

G

G

A

A

A

G

C

A

A

A

A

G

T

A

T

T

T

G

A

G

A

G

C

C

A

G

T

G

C

A

G

T

G

C

C

T

T

G

G

T

G

T

T

G

G

G

T

G

A

A

A

C

A

T

A

G

A

T

T

G

A

A

T

T

T

G

G

G

C

C

A

T

T

T

G

T

T

T

A

A

A

C

T

T

C

C

T

A

G

G

C

C

T

C

A

G

T

T

T

C

T

T

G

C

C

T

A

T

T

A

A

A

A

G

G

G

A

G

T

G

C

A

T

A

G

T

T

C

A

T

G

G

G

A

T

T

G

T

T

A

A

G

A

G

G

A

A

G

A

A

G

T

G

A

A

A

C

C

A

T

G

C

A

C

G

T

G

G

A

G

A

G

C

G

T

G

G

C

A

C

A

G

T

G

T

C

T

A

A

G

A

C

A

G

A

G

T

G

T

G

C

A

T

G

C

A

A

A

T

A

A

G

T

A

G

A

T

A

A

T

A

T

T

C

T

T

T

G

C

T

T

T

T

C

T

T

T

A

T

T

G

C

A

T

G

C

C

T

G

T

A

A

T

A

T

T

T

T

T

G

G

A

G

T

T

G

T

C

A

C

A

T

T

C

A

T

T

G

C

C

C

T

C

A

A

G

T

A

G

C

A

T

C

A

A

G

G

G

A

T

G

A

A

A

T

T

A

T

G

T

T

T

G

T

A

A

G

A

A

A

A

T

C

C

T

G

A

G

G

C

T

G

A

G

G

A

A

T

A

C

A

A

C

A

T

G

T

T

T

T

A

T

G

T

C

T

A

C

T

A

C

A

C

T

G

A

A

A

A

A

T

G

C

C

G

G

A

G

T

C

A

G

A

T

A

A

A

G

A

A

T

A

C

A

G

A

T

T

C

T

C

C

T

G

A

G

G

A

T

G

G

A

A

A

T

C

A

A

G

A

T

C

T

T

C

G

C

C

T

T

C

A

A

T

A

T

T

T

A

A

C

A

A

C

A

T

T

G

A

G

C

T

T

C

C

A

A

C

T

T

A

C

T

A

T

G

G

G

A

A

A

T

A

T

T

C

A

T

C

A

G

G

C

C

C

C

T

A

A

A

G

G

T

T

C

C

T

T

T

T

G

G

A

C

A

G

A

A

A

T

T

G

C

A

C

T

T

G

T

T

A

T

A

T

C

T

G

T

A

T

T

C

T

T

A

G

C

A

G

A

C

A

G

T

A

G

A

C

A

G

C

C

T

G

G

C

A

C

A

T

C

A

T

A

A

A

G

G

C

T

T

A

A

G

G

A

A

T

C

C

T

A

A

A

T

A

T

C

C

C

T

T

A

A

A

A

T

T

C

T

C

A

T

T

T

T

A

A

A

G

A

C

A

A

A

A

A

C

A

A

A

A

C

A

A

A

A

A

A

A

A

A

A

A

A

C

A

A

A

A

A

A

A

A

A

C

T

G

A

G

G

C

A

T

G

G

G

C

T

T

G

A

C

C

A

A

A

T

C

A

G

T

G

G

T

A

G

A

A

C

C

A

A

G

A

G

T

T

A

A

A

C

C

A

C

T

T

G

T

T

T

T

G

A

A

T

C

C

T

A

A

A

C

C

T

G

A

G

T

T

T

T

A

T

T

T

T

A

C

T

T

A

T

T

T

A

T

T

T

A

T

T

T

A

T

T

T

G

T

T

T

A

T

T

T

A

T

T

T

T

C

A

G

A

T

G

C

T

T

G

G

T

C

A

A

A

G

A

A

C

A

G

T

G

G

G

A

G

G

A

G

A

G

G

G

A

T

G

G

G

C

T

T

C

C

A

G

C

A

A

C

C

T

T

T

A

T

T

A

T

T

G

G

C

T

T

A

T

T

T

T

C

T

T

A

C

A

G

C

C

C

A

T

T

A

C

T

T

T

C

T

C

T

T

G

G

G

A

A

A

A

T

A

T

T

A

A

G

C

A

G

G

C

A

C

T

C

A

A

G

G

C

T

T

G

A

G

G

C

C

C

C

T

G

A

G

T

T

T

T

C

A

C

A

T

C

C

T

T

T

C

T

G

A

A

C

C

T

C

T

G

A

A

C

C

T

G

C

T

T

T

C

C

A

G

C

A

T

T

C

T

T

T

T

A

T

A

C

T

T

T

G

T

T

T

T

A

C

C

T

C

C

T

G

G

T

C

A

G

T

A

A

T

G

C

C

T

C

A

C

C

C

T

C

A

G

T

C

T

T

C

T

C

T

A

A

A

A

G

T

G

T

G

G

T

T

A

A

T

G

G

C

A

T

C

T

T

C

C

T

G

A

C

T

A

T

T

T

G

A

A

G

A

C

C

A

C

T

G

G

C

C

A

A

A

T

C

C

C

A

C

C

A

G

C

T

C

A

C

T

C

A

T

A

G

A

C

C

A

T

C

C

C

C

C

T

A

C

T

T

T

A

C

T

T

T

C

T

T

C

A

A

A

A

G

A

C

T

T

A

G

C

C

C

T

A

C

C

T

A

A

A

C

T

T

A

T

T

T

A

T

A

T

G

T

T

T

A

T

T

T

T

C

T

G

C

C

C

A

C

C

A

G

A

A

T

G

G

C

A

G

C

A

T

A

G

C

T

G

G

G

G

A

G

G

C

A

G

A

G

T

C

T

G

T

T

T

T

G

T

T

C

A

T

T

G

C

T

G

T

A

T

T

C

C

C

A

A

A

G

A

C

T

A

G

A

A

C

A

C

C

A

C

C

A

A

G

C

A

C

A

C

G

G

T

A

C

A

G

G

T

C

T

C

A

G

T

A

A

T

T

A

T

T

G

T

C

A

A

A

T

T

T

A

T

G

T

G

G

A

T

T

T

G

C

T

T

T

T

A

A

A

C

A

A

T

A

T

C

T

T

C

C

A

T

T

T

A

C

T

G

A

G

T

G

T

T

T

A

T

G

T

G

G

A

A

G

A

A

C

T

G

T

A

C

T

A

A

A

T

T

T

T

A

A

T

G

C

A

T

T

T

C

T

T

T

A

T

T

C

C

T

A

T

T

C

T

T

A

A

A

A

C

C

T

T

C

C

A

G

C

A

A

G

G

T

G

G

C

T

C

T

A

C

C

A

C

C

C

T

C

T

T

T

T

C

C

G

A

G

C

T

T

C

A

G

G

A

G

C

A

G

T

T

G

T

G

C

G

A

A

T

A

G

C

T

G

G

A

G

A

A

C

A

C

C

A

G

G

C

T

G

G

A

T

T

T

A

A

A

C

C

C

A

G

A

T

C

G

C

T

C

T

T

A

C

A

T

T

T

G

C

T

C

T

T

T

A

C

C

T

G

C

T

G

T

G

C

T

C

A

G

C

G

T

T

C

A

C

G

T

G

C

C

C

T

C

T

A

G

C

T

G

T

A

G

T

T

T

T

C

T

G

A

A

G

T

C

A

G

C

G

C

A

C

A

G

C

A

A

G

G

C

A

G

T

G

T

G

C

T

T

A

G

A

G

G

T

T

A

A

C

A

G

A

A

G

G

G

A

A

A

A

C

A

A

C

A

A

C

A

A

C

A

A

A

A

A

T

C

T

A

A

A

T

G

A

G

A

A

T

C

C

T

G

A

C

T

G

T

T

T

Matrix 1

Matrix 2

Sequence NM_006657.1:chr21

G

G

G

C

T

T

A

C

C

T

G

G

C

T

C

C

T

G

T

C

T

C

A

T

C

C

C

A

G

T

C

C

C

C

C

T

G

A

G

T

A

G

C

C

A

C

G

G

A

G

G

T

G

G

G

G

T

C

C

C

T

A

A

G

G

C

C

C

A

C

A

T

G

G

T

T

G

G

G

G

T

T

C

C

A

T

T

A

A

G

A

A

C

T

T

C

A

A

G

T

G

G

G

T

G

G

C

T

C

A

C

G

C

C

T

G

T

A

A

T

C

C

C

A

G

C

A

C

T

T

T

G

G

G

A

G

A

C

C

G

A

G

G

T

G

G

G

T

G

G

A

T

C

A

T

G

A

G

G

T

C

A

A

G

A

G

A

T

C

G

A

G

A

C

C

A

T

C

C

T

G

G

C

C

A

A

C

A

T

G

G

T

G

A

A

A

C

C

C

C

A

T

C

T

C

T

A

C

T

A

A

A

A

A

T

A

C

A

A

A

A

A

A

T

T

A

G

C

T

G

G

G

T

G

T

G

G

T

A

G

C

G

G

G

T

G

C

C

T

G

T

A

G

T

C

C

C

A

G

C

T

A

C

T

C

T

G

G

A

G

G

C

T

G

A

G

G

C

A

G

G

A

G

A

A

T

G

G

C

G

T

G

A

A

C

C

C

G

G

G

A

G

G

C

A

G

A

G

C

T

T

G

C

A

G

T

G

A

G

C

C

A

A

G

A

T

C

G

C

A

C

C

A

C

T

G

C

A

C

T

C

C

A

G

C

C

T

G

G

G

C

G

A

C

A

G

A

G

C

G

A

G

A

C

C

C

T

G

T

C

T

C

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

G

A

A

C

T

T

C

A

A

G

T

G

G

G

G

C

T

G

G

G

C

T

C

A

G

T

G

G

C

T

C

A

C

A

C

T

T

G

T

A

A

T

T

C

C

A

G

C

A

C

T

T

T

G

G

G

A

G

G

C

C

G

A

G

G

C

A

G

G

A

G

G

A

T

C

G

C

T

T

G

A

G

C

C

C

A

G

G

A

G

T

T

T

G

A

G

A

C

C

A

G

C

C

T

G

G

G

C

A

A

C

G

T

G

G

T

G

A

G

A

C

C

T

C

A

T

G

T

G

T

A

T

T

T

G

T

C

T

G

A

T

A

A

A

G

A

C

A

T

A

C

G

C

A

A

G

A

C

T

G

G

G

T

A

A

T

T

T

T

T

A

A

A

G

A

A

A

A

A

G

C

A

G

T

T

T

A

A

T

G

G

A

C

T

C

A

A

C

A

G

T

T

C

C

A

C

A

A

T

C

A

T

G

G

T

G

G

A

A

G

G

T

G

A

A

A

G

A

G

G

A

G

C

A

A

A

G

T

C

A

C

G

T

C

T

T

A

C

A

A

G

A

G

G

G

T

G

T

G

T

G

C

A

G

G

G

G

A

A

C

T

G

C

C

C

T

T

T

A

T

A

A

A

A

C

C

A

T

C

G

G

A

T

C

T

C

G

T

G

A

G

A

C

C

A

T

T

C

A

C

T

A

T

C

A

C

A

A

A

A

A

C

A

G

C

A

C

C

G

G

A

A

A

A

A

G

C

C

G

C

C

C

C

C

G

T

G

A

T

T

C

A

G

T

G

A

C

C

T

C

C

C

A

C

C

G

G

G

T

C

C

C

T

C

C

C

A

T

G

A

C

G

T

G

G

G

A

A

C

T

A

T

G

G

G

C

T

C

T

A

C

A

A

T

T

C

A

A

G

A

T

G

A

G

A

T

T

T

A

G

G

T

G

G

G

G

A

C

A

C

A

G

C

C

A

A

A

C

C

A

T

A

T

C

A

C

C

A

T

G

T

C

T

A

C

C

A

A

A

A

A

T

G

G

A

A

A

A

G

T

T

A

G

C

C

A

G

T

G

T

A

G

T

G

G

T

G

T

G

T

G

C

C

T

G

T

G

G

C

C

C

A

G

A

T

G

C

T

C

A

G

G

A

G

G

C

T

A

A

G

G

T

G

A

A

A

G

G

A

C

C

T

C

T

T

G

A

G

C

C

T

G

G

G

G

A

C

C

A

A

G

G

C

T

G

C

A

G

G

A

A

G

C

C

A

T

G

A

T

T

G

T

G

C

C

G

C

T

G

C

A

C

T

C

C

A

G

C

C

T

G

G

C

T

G

A

C

A

G

A

G

T

G

A

G

A

C

T

T

T

G

T

C

T

C

A

A

A

A

A

A

A

A

A

A

A

A

A

A

G

A

G

A

A

A

A

T

G

A

T

A

A

A

A

G

C

A

C

T

G

C

A

A

G

T

G

G

G

C

A

G

C

G

G

C

T

G

A

A

C

G

T

G

G

A

G

A

C

A

G

G

A

G

T

T

C

T

C

C

C

T

T

C

T

G

A

G

C

A

C

G

G

C

C

C

T

G

G

T

G

C

C

G

C

T

G

A

C

T

T

C

G

T

G

G

G

G

A

G

C

C

T

G

T

A

G

T

C

A

G

G

G

G

A

G

C

A

G

C

A

G

C

T

G

G

G

G

A

G

A

G

C

T

G

G

G

G

T

C

T

C

A

G

C

T

G

C

C

T

T

C

C

C

C

C

A

T

A

T

C

G

C

A

C

A

T

G

C

C

C

G

T

C

T

C

G

T

G

T

G

T

A

T

C

T

G

C

A

C

T

C

T

C

A

C

A

C

G

C

G

T

G

T

T

C

C

C

C

T

G

C

C

C

T

G

C

G

C

T

C

A

C

A

T

G

T

A

T

C

T

G

C

A

C

T

C

A

C

T

C

T

C

A

C

A

T

G

C

T

T

G

C

T

T

C

C

C

C

T

G

C

C

C

C

A

T

G

C

T

C

A

C

G

T

G

T

A

C

C

T

G

C

A

C

T

C

T

C

A

C

A

C

G

T

G

T

G

C

T

C

C

C

C

T

A

C

C

C

C

A

C

A

C

T

C

A

C

A

T

G

T

A

T

C

C

T

C

G

C

T

C

A

C

T

C

T

C

A

C

A

C

G

T

G

T

T

C

C

C

C

T

G

T

C

C

T

G

T

G

C

T

C

A

C

A

T

G

T

A

T

C

C

A

C

G

C

T

C

T

C

A

C

A

C

A

T

G

T

G

C

T

C

C

C

C

T

G

C

C

T

T

G

T

G

C

T

C

A

C

G

T

G

T

A

T

C

T

G

C

A

C

T

C

T

C

A

C

G

T

G

T

T

C

C

C

C

T

G

C

C

C

T

G

C

C

C

T

C

A

C

G

T

G

T

A

T

C

C

T

C

A

C

T

C

A

C

T

C

T

C

A

C

A

C

G

C

G

T

G

C

T

C

C

C

C

T

G

C

A

C

T

C

T

C

C

T

G

T

C

T

G

A

G

C

T

G

A

G

C

T

G

A

C

C

T

C

A

G

T

T

G

G

G

T

G

C

T

G

C

G

A

G

C

C

A

G

G

G

C

C

T

C

A

T

G

C

T

G

G

C

C

T

C

T

C

G

C

C

C

T

C

C

A

C

A

G

C

C

C

C

A

G

G

G

G

T

C

C

A

G

G

C

T

C

C

T

C

C

A

G

G

A

A

C

A

A

A

C

G

C

A

G

G

C

C

C

C

A

C

G

G

G

C

T

G

C

C

T

G

G

A

A

G

G

C

C

T

C

C

C

A

G

A

A

G

G

C

A

G

C

A

C

A

G

G

G

T

C

A

C

G

A

G

G

G

T

C

A

C

C

C

G

C

A

G

T

G

G

C

A

C

A

G

G

G

A

G

G

C

C

T

C

G

T

C

A

C

G

A

C

A

G

G

A

T

T

C

C

A

G

C

C

A

G

G

C

T

G

G

C

C

T

G

A

T

G

C

T

C

C

T

G

G

G

G

G

T

C

C

T

C

G

G

C

A

C

A

T

G

C

C

C

C

T

T

C

A

C

C

C

T

G

G

C

A

T

G

T

G

C

T

T

C

T

T

T

T

C

C

G

G

G

A

A

C

C

C

A

C

A

C

T

C

T

G

G

C

T

G

A

G

T

G

G

A

G

C

C

A

T

C

C

C

C

T

C

T

G

G

G

T

C

A

A

C

A

G

C

A

C

C

C

G

G

G

G

T

G

G

C

T

C

T

G

C

A

G

C

A

C

C

C

C

A

C

T

C

C

G

C

G

G

C

T

G

C

A

C

A

G

G

G

A

C

C

T

T

G

G

C

C

C

C

A

C

T

G

C

T

C

C

T

T

G

T

G

C

C

T

T

G

C

T

G

G

T

T

A

A

T

G

A

G

A

A

G

C

C

G

G

T

G

G

G

G

A

G

G

T

G

C

T

G

C

C

G

G

T

G

A

G

C

G

T

A

T

A

A

A

G

G

C

C

C

T

G

G

C

G

G

C

G

G

C

T

G

C

G

G

A

G

C

A

C

T

G

G

C

C

C

T

G

T

C

Matrix 1

Matrix 2

Sequence NM_017545.1:chr20

T

T

G

G

A

A

T

G

T

A

G

A

T

A

G

T

G

A

A

C

A

A

C

T

G

G

C

A

A

G

C

A

G

C

T

T

T

A

A

G

T

G

G

C

G

G

C

T

C

C

T

A

G

A

T

T

G

A

A

A

C

T

C

A

G

G

T

C

T

A

A

C

T

G

T

A

G

T

T

A

A

A

A

T

C

A

T

T

G

C

T

T

T

C

T

C

A

A

G

C

A

T

A

T

C

C

T

A

C

T

A

A

T

G

T

G

A

A

T

C

T

T

C

C

C

C

A

G

G

T

G

T

T

C

C

A

T

G

A

T

T

G

A

G

T

G

A

A

A

T

T

A

T

A

G

A

C

T

G

A

G

A

C

C

A

C

A

G

G

T

C

T

T

T

T

G

G

A

A

T

A

G

C

A

C

T

T

C

C

C

T

A

T

A

C

C

C

T

C

T

C

C

A

G

G

G

C

A

A

G

A

T

A

A

G

A

C

T

C

T

A

A

G

A

A

T

T

A

G

T

G

G

T

A

G

G

C

C

A

T

G

T

G

C

A

G

T

G

G

C

T

C

A

C

A

C

C

T

G

C

A

A

T

C

C

C

A

G

C

A

C

T

C

T

G

G

G

A

G

G

C

C

G

A

G

G

T

G

G

T

T

G

G

A

T

C

A

C

T

T

G

A

G

G

T

C

A

G

G

A

G

T

T

T

G

A

G

A

C

C

A

G

C

C

T

G

G

C

C

A

A

T

A

T

A

G

T

G

A

A

A

C

C

C

C

A

T

C

T

T

T

A

C

T

A

A

A

T

A

A

A

A

A

T

A

C

A

A

A

A

A

T

T

A

G

C

C

A

G

G

C

G

T

G

G

T

G

G

A

C

A

T

G

C

C

T

G

T

A

G

T

C

C

C

A

G

T

T

A

C

T

T

G

G

G

A

G

G

C

T

G

A

G

G

C

A

G

A

A

T

A

A

T

C

T

C

T

T

G

A

A

C

C

T

G

G

G

A

G

G

T

A

G

A

G

G

C

T

G

C

A

A

T

G

A

G

C

C

G

A

G

A

T

C

A

C

A

C

C

A

C

T

G

C

A

C

T

C

C

A

G

C

C

T

G

G

G

A

G

A

C

A

G

A

G

A

A

A

G

A

C

T

C

C

A

T

C

T

C

A

A

A

A

A

G

A

A

A

A

A

A

A

A

A

A

A

G

A

A

T

T

A

A

T

G

G

T

A

A

A

C

C

T

A

A

A

T

G

C

C

C

A

T

T

A

A

G

A

G

A

C

A

A

A

T

G

G

A

T

A

A

G

G

G

A

A

A

T

G

T

A

T

A

G

A

T

A

T

A

C

A

C

A

C

A

A

T

G

A

A

A

T

A

T

T

A

T

T

C

A

G

C

C

T

T

A

T

A

A

G

A

G

A

A

G

G

G

A

A

T

C

C

T

G

T

C

A

T

T

T

G

C

A

G

T

A

G

A

A

C

C

C

A

G

A

G

A

A

C

A

T

T

A

T

G

C

T

A

A

G

T

G

A

A

A

T

A

A

G

C

C

A

G

G

C

A

C

A

A

A

A

G

G

G

A

A

A

T

T

A

T

T

G

C

A

T

T

A

T

T

T

C

A

C

T

T

A

T

A

G

G

T

G

G

G

A

T

T

T

T

G

T

T

T

T

A

A

A

A

A

A

G

A

C

T

T

C

A

A

A

T

G

C

A

C

A

G

A

G

C

T

A

G

A

G

A

A

T

G

A

A

A

C

A

G

T

G

A

A

T

A

C

C

A

C

T

A

G

T

G

G

G

A

A

G

C

A

G

G

G

A

A

G

A

G

G

A

A

A

A

G

G

G

G

T

G

A

T

A

T

A

G

G

T

C

A

A

A

G

G

A

T

A

C

A

A

A

A

T

A

G

T

A

G

A

C

A

C

G

T

A

G

G

A

T

A

C

A

T

A

A

A

T

C

T

A

C

A

A

C

A

G

G

G

T

C

C

C

T

A

A

C

C

T

T

T

T

C

G

G

C

A

C

C

A

G

G

G

A

C

A

A

G

T

T

T

T

G

T

G

G

A

A

T

A

C

A

A

T

T

T

T

T

C

C

A

T

G

G

G

C

A

G

T

G

G

G

G

G

T

A

G

G

T

G

G

A

T

G

G

T

T

T

T

G

G

A

A

T

G

A

A

A

C

T

G

T

T

C

C

A

C

C

T

C

A

G

A

T

C

A

T

C

A

G

G

C

A

T

T

A

G

A

T

T

C

T

C

A

T

A

A

G

G

A

G

T

G

G

C

G

C

A

A

C

C

T

A

G

A

T

C

C

C

T

C

G

C

A

T

G

T

G

C

A

G

T

T

C

A

C

A

A

T

A

G

G

A

G

G

C

G

G

A

G

C

T

C

A

G

T

C

T

G

T

A

A

A

G

C

T

T

G

C

T

C

A

C

C

G

G

C

T

G

C

T

C

A

C

C

T

C

C

T

G

C

T

G

T

G

C

A

G

C

T

T

G

G

T

T

C

C

T

A

A

C

A

G

G

C

C

A

C

G

G

A

C

C

A

G

T

A

C

C

A

G

T

C

C

A

T

G

C

T

G

G

G

G

A

G

T

T

T

G

G

G

A

C

C

C

C

T

G

G

T

C

T

A

G

A

G

A

G

C

A

A

A

C

G

T

G

C

A

A

A

A

T

G

A

G

G

A

C

T

A

A

A

G

T

T

A

A

T

A

A

A

A

T

T

G

T

A

T

C

A

T

A

T

T

A

G

G

A

A

T

T

T

T

T

G

T

T

A

A

A

T

A

A

G

T

T

G

A

T

T

T

T

A

G

C

T

G

T

T

C

T

T

G

T

C

A

T

A

C

A

C

A

C

A

A

A

A

A

A

G

T

A

A

T

T

A

C

G

G

G

T

G

A

G

A

T

G

A

T

A

C

A

T

A

T

A

T

T

A

T

A

T

T

G

G

C

C

T

C

C

C

T

A

C

T

G

T

A

A

C

C

A

T

T

T

T

T

C

T

G

T

G

T

A

T

A

T

G

T

A

T

C

T

C

A

T

A

A

T

A

T

C

A

T

G

T

T

G

T

A

A

A

C

C

T

C

A

A

A

T

A

T

A

C

A

G

A

A

T

G

A

A

T

A

A

A

A

C

A

A

T

T

A

G

C

T

G

T

C

A

A

T

T

T

G

G

C

C

T

T

A

A

T

G

T

T

C

C

A

T

G

T

T

A

A

A

G

C

C

A

A

A

T

G

T

C

T

A

T

G

T

T

T

G

T

A

A

T

C

A

G

C

T

A

A

A

T

T

T

T

A

T

A

T

T

G

T

G

C

A

G

A

A

G

C

C

C

T

G

A

A

T

T

T

C

A

C

G

G

A

T

G

C

C

C

C

A

T

A

T

T

T

C

A

T

G

G

A

T

G

C

C

C

C

G

T

T

C

A

G

T

T

C

A

T

A

A

G

C

T

C

T

T

G

T

T

T

A

C

A

T

G

A

T

T

T

G

T

G

C

A

T

G

A

T

C

C

A

A

A

T

G

T

G

G

A

A

A

G

A

A

A

A

T

G

A

G

T

G

G

G

C

A

G

C

C

T

A

T

T

C

T

G

G

G

T

A

T

C

A

A

G

C

A

A

A

G

A

G

C

A

C

A

G

G

C

A

C

A

G

A

C

C

A

T

G

T

G

C

A

A

T

A

A

G

C

A

G

C

C

T

T

A

G

G

C

A

A

A

A

C

T

G

A

A

C

C

A

A

G

A

G

T

G

G

T

T

T

C

A

T

A

C

A

G

G

T

A

T

T

C

C

T

C

T

A

A

G

T

C

T

T

T

A

A

T

T

T

T

T

T

A

C

T

T

A

T

T

C

C

T

T

T

C

C

C

C

T

T

T

T

T

A

A

T

G

T

G

A

T

A

G

A

C

A

C

C

T

A

A

T

C

A

C

C

T

T

C

T

G

C

T

G

C

C

T

T

C

C

C

A

A

C

C

T

C

A

A

C

T

T

T

G

G

T

G

T

T

C

T

T

T

G

G

C

A

G

A

T

A

G

T

G

A

C

T

T

C

G

G

T

G

T

T

C

T

T

T

G

G

C

A

G

A

T

A

G

C

C

T

A

C

A

A

A

T

G

A

A

A

T

T

T

C

A

A

A

G

G

C

T

A

A

G

C

A

T

A

T

A

A

T

G

T

T

T

G

C

T

C

A

C

T

T

G

A

T

G

T

A

A

G

C

A

A

C

A

G

A

G

A

A

C

T

A

A

A

T

C

T

G

A

A

C

T

T

T

G

G

C

A

A

A

A

G

T

C

T

A

T

T

A

A

T

A

A

T

T

G

A

C

A

A

A

T

A

A

C

A

G

A

A

C

A

G

T

G

A

G

G

A

T

G

T

A

G

A

A

A

G

C

A

A

T

A

C

A

T

T

A

A

A

A

A

A

A

A

A

A

A

A

A

C

A

A

C

G

A

A

C

T

C

C

A

T

Matrix 1

Matrix 2

Sequence NM_001639.1:chr1

A

T

C

T

A

T

A

A

T

A

T

G

A

G

A

C

A

G

A

T

A

G

T

G

G

T

A

A

C

A

G

C

C

A

T

A

A

A

G

G

C

T

C

T

A

A

A

A

T

G

A

T

G

G

T

A

A

T

A

A

T

A

A

C

C

A

T

C

C

A

G

A

T

A

C

T

G

T

T

C

C

A

T

G

T

A

C

T

T

T

A

T

G

T

A

T

A

T

C

A

T

A

G

T

A

T

C

T

C

A

T

T

T

A

T

C

C

T

T

A

G

A

G

A

A

A

C

A

C

T

G

T

G

A

G

G

T

A

G

A

T

A

G

T

T

T

T

A

T

C

T

T

T

G

T

T

T

C

A

C

A

G

A

G

A

A

G

G

A

A

A

C

T

A

A

G

G

T

T

C

A

G

A

G

G

G

G

T

T

T

A

G

T

G

A

C

T

T

G

C

A

G

A

A

T

A

G

T

C

A

G

C

C

A

C

T

A

G

T

A

A

A

T

G

G

C

A

A

C

A

T

T

G

G

A

A

T

T

C

T

A

T

C

C

C

A

A

A

G

T

C

T

T

T

G

A

T

C

T

T

A

A

C

C

T

T

A

T

G

G

G

A

A

G

T

A

C

G

A

A

A

G

A

G

G

G

G

A

A

A

T

A

A

T

G

T

A

T

A

G

T

T

G

G

G

A

T

A

T

T

A

G

A

A

A

A

G

T

C

T

T

C

A

T

G

A

A

G

C

A

G

A

T

T

G

T

T

T

T

T

T

A

T

T

T

T

T

T

A

T

A

T

T

T

T

T

G

T

A

T

A

A

A

T

T

C

A

A

G

G

C

A

T

A

C

A

A

G

T

T

T

A

G

T

T

T

T

A

T

T

A

C

A

T

A

G

A

C

A

G

C

A

A

T

A

A

C

A

T

A

A

T

A

G

T

G

A

A

G

T

C

T

G

G

G

C

T

T

T

T

A

C

T

A

T

A

A

C

C

A

T

C

A

C

C

T

A

A

A

T

A

A

G

C

T

T

G

A

G

A

T

T

A

A

T

G

T

G

G

A

A

G

A

A

T

G

G

C

T

G

G

A

A

T

T

C

C

T

A

G

A

A

A

C

A

G

G

A

A

A

A

G

A

A

A

A

T

A

A

G

A

G

A

G

A

A

A

T

T

C

A

A

G

A

C

A

G

T

A

T

G

A

A

G

G

C

A

C

T

G

A

A

T

A

G

A

A

G

T

A

A

T

G

A

A

A

T

C

A

A

G

A

A

A

G

C

C

A

G

G

A

A

G

G

T

A

T

A

A

A

G

A

A

C

A

A

C

A

A

T

T

A

G

A

G

G

T

G

T

T

T

G

A

C

T

G

G

A

G

A

A

T

A

G

G

A

T

T

A

G

A

T

T

C

T

G

A

G

A

T

A

A

T

A

G

C

C

A

G

G

T

T

A

G

A

G

C

C

A

G

A

T

T

G

C

A

A

A

T

G

G

C

A

T

T

G

G

C

T

T

C

C

A

A

G

C

A

A

A

T

G

G

T

C

T

G

T

A

T

T

T

A

A

T

T

C

A

G

G

A

G

T

C

A

A

T

A

G

A

T

G

C

A

T

A

A

T

C

C

C

A

A

C

T

T

T

A

T

C

A

C

T

A

A

C

C

T

A

T

A

C

T

G

T

G

C

A

A

C

A

A

G

C

C

A

G

A

T

A

A

G

G

C

T

T

C

A

C

A

A

C

C

T

G

G

G

A

T

T

C

C

A

T

T

T

A

G

A

G

A

A

A

A

A

A

A

G

T

A

G

A

G

A

A

T

G

G

A

A

A

C

T

C

C

C

C

A

G

G

G

A

T

G

A

G

A

A

T

A

G

G

A

A

G

G

A

T

A

C

T

T

T

G

A

A

C

A

A

T

G

A

T

A

G

A

G

A

A

A

G

T

G

T

A

T

T

C

T

T

G

G

T

G

G

C

A

G

T

G

A

T

T

G

T

G

T

C

A

T

T

G

A

A

A

A

G

G

C

T

G

A

T

T

A

G

G

T

C

T

G

T

G

G

T

G

A

G

C

T

A

A

C

A

G

A

A

G

A

G

A

G

A

G

T

G

A

A

C

A

A

G

A

G

G

C

T

A

A

A

C

A

G

T

A

G

G

A

T

G

A

G

A

A

A

C

A

A

G

A

C

A

C

C

A

T

A

T

A

A

T

T

C

A

G

G

G

A

T

G

A

G

A

G

A

G

A

A

A

G

A

A

A

T

A

A

T

G

T

G

G

C

T

A

G

A

A

A

G

A

A

G

A

A

C

T

T

C

A

G

T

T

T

G

A

T

A

T

C

T

C

A

G

A

G

G

C

A

G

A

G

A

A

G

G

T

T

T

G

A

G

T

G

G

T

G

G

T

T

A

A

T

A

A

A

C

T

G

T

A

C

A

G

A

G

A

G

A

G

A

A

T

G

A

A

G

G

A

G

A

C

A

T

A

G

A

A

A

G

A

A

T

G

A

A

G

G

T

G

G

A

G

A

T

C

T

C

T

G

G

G

G

C

T

G

T

G

A

G

A

G

A

G

C

C

A

G

T

G

A

C

C

A

C

T

G

A

A

T

C

C

C

C

A

G

C

A

C

C

T

A

G

T

G

T

A

G

T

A

A

C

T

G

A

G

A

G

C

T

A

G

T

G

A

A

T

A

A

A

T

G

T

A

T

T

A

G

T

G

G

G

G

T

C

A

T

C

A

C

C

A

A

A

G

A

T

G

G

A

T

T

A

G

A

T

A

T

A

C

A

C

T

C

A

A

T

G

A

C

C

A

A

G

G

A

C

T

C

A

A

A

G

A

A

G

A

G

G

A

G

A

G

A

A

A

A

A

C

T

T

G

G

G

G

A

G

A

T

G

C

T

G

A

C

A

T

C

T

C

T

G

C

A

G

G

T

A

G

C

A

T

G

A

A

G

T

A

A

C

C

A

G

A

A

A

A

C

A

A

G

T

C

G

T

A

A

T

G

A

G

A

A

A

T

G

G

A

A

A

G

A

T

C

T

A

G

G

A

T

A

A

G

G

A

A

G

C

A

C

C

A

T

G

A

T

A

T

G

C

A

A

A

C

G

A

A

A

A

A

A

A

A

G

C

A

C

T

G

A

G

T

A

G

A

A

G

T

A

G

C

A

G

A

A

A

A

A

T

A

C

T

A

A

G

C

T

T

C

A

T

G

G

G

G

A

C

A

G

A

A

A

G

T

T

T

A

T

T

C

T

C

C

A

A

G

T

C

C

C

T

C

T

T

T

C

C

C

C

T

T

A

G

C

T

T

T

G

C

C

T

G

G

A

T

G

T

A

T

T

A

C

T

T

G

A

T

G

T

T

G

A

A

T

T

A

G

T

C

A

A

A

G

T

T

G

A

A

G

G

C

A

C

T

T

T

T

T

A

G

G

G

T

C

T

T

C

A

G

C

A

G

A

A

A

G

C

A

G

A

A

T

C

C

T

A

G

A

A

T

A

T

C

C

T

A

C

A

A

A

T

A

C

A

A

G

A

C

A

A

C

T

T

G

A

G

A

A

C

T

A

T

A

A

A

A

G

A

A

A

G

A

A

A

A

G

G

C

C

T

T

G

T

T

C

C

C

A

T

A

G

C

C

C

A

C

A

A

G

A

G

G

G

C

T

G

A

G

C

T

C

A

G

C

G

A

T

A

C

A

C

T

C

T

G

T

G

T

G

G

C

T

C

A

G

G

A

G

C

T

T

C

T

G

G

C

A

G

A

G

C

A

C

A

G

A

G

C

C

A

T

C

A

G

A

G

A

G

G

G

G

G

C

C

C

A

G

A

G

A

G

C

A

G

A

G

A

G

A

G

G

C

T

C

T

G

C

T

G

A

C

A

T

G

G

C

C

A

G

C

C

C

A

G

C

G

C

C

T

C

A

T

C

C

C

A

T

C

C

A

T

A

A

C

C

C

T

G

C

T

G

C

C

C

T

G

C

A

A

T

G

A

C

T

C

T

C

T

T

C

C

C

A

G

C

A

A

T

A

A

A

A

T

C

T

G

G

G

T

C

A

C

A

G

G

A

G

T

T

G

G

A

G

C

T

C

T

A

G

C

C

A

T

C

A

C

T

T

G

T

C

T

C

T

A

A

T

A

A

A

T

A

A

C

T

C

C

C

A

T

T

G

A

T

T

T

T

C

C

A

G

C

T

C

A

G

G

G

C

T

C

A

C

C

A

C

T

C

C

T

T

C

A

C

C

G

T

A

A

G

C

G

C

C

A

G

G

A

G

G

C

A

G

A

C

C

T

G

G

A

A

A

A

T

C

A

C

T

C

A

C

A

T

A

T

T

A

T

T

G

G

T

G

C

T

C

T

T

C

C

T

C

C

C

C

C

A

T

C

C

T

C

A

C

C

C

A

A

G

G

T

G

C

A

T

A

T

A

A

A

C

C

C

T

G

A

A

T

A

A

C

C

T

G

A

A

G

T

C

T

A

Matrix 1

Matrix 2

Sequence NM_000371.1:chr18

A

G

A

A

A

A

G

G

C

T

C

T

C

T

A

T

C

C

A

G

G

T

T

C

T

G

A

A

C

A

A

T

A

G

G

A

A

A

T

C

A

T

C

A

A

G

A

G

G

A

T

A

T

T

G

G

A

T

G

A

C

A

A

T

A

T

A

T

G

A

A

A

G

A

T

G

T

T

A

T

T

T

G

A

G

A

A

A

G

G

A

T

T

C

T

C

T

C

C

T

G

A

G

G

C

A

T

A

G

A

T

G

T

T

G

A

A

C

C

A

A

A

T

T

C

T

A

T

T

A

G

T

T

A

T

G

C

T

T

T

T

A

C

A

G

C

A

A

G

A

T

A

G

T

G

G

T

T

T

A

C

A

G

C

T

T

A

C

A

A

A

A

G

G

C

T

T

G

T

A

C

A

T

C

C

T

C

T

C

A

T

A

T

T

A

A

A

A

G

T

T

A

T

T

A

G

A

A

C

A

G

T

C

C

T

T

T

G

A

A

G

T

A

G

A

A

A

A

G

T

A

G

G

C

A

T

T

T

C

T

A

T

T

T

T

A

C

A

A

A

C

G

A

G

T

T

G

G

C

C

G

A

G

T

A

T

C

T

G

A

G

A

T

A

G

T

A

G

A

T

A

A

C

T

C

A

T

A

G

A

A

G

G

T

C

A

T

C

C

G

G

G

A

A

A

C

G

G

G

G

C

A

G

C

A

G

A

A

C

T

G

G

G

A

T

C

G

A

A

T

G

A

C

T

C

T

G

G

T

C

A

T

C

C

A

A

C

T

C

C

A

A

A

T

G

C

A

A

A

A

G

T

C

T

T

T

C

T

G

C

T

G

C

T

G

C

T

T

C

C

T

A

G

T

T

A

A

A

C

T

C

T

A

A

G

G

G

T

C

T

A

A

G

A

C

T

C

C

A

T

T

C

C

T

A

G

T

T

A

T

G

G

T

C

T

C

A

A

C

T

A

C

A

T

T

T

G

C

T

C

A

T

T

G

C

T

G

T

G

A

G

G

G

G

T

C

A

A

C

C

C

A

C

C

T

C

C

C

G

G

A

G

T

C

C

T

C

T

C

C

T

G

C

A

C

A

T

T

C

T

C

A

T

G

T

T

C

C

T

G

A

A

A

G

G

C

T

T

T

T

C

T

G

T

C

C

C

T

T

C

C

A

C

T

A

C

T

C

C

C

T

G

T

A

A

G

C

T

C

C

T

G

T

G

C

T

T

C

A

C

A

A

T

T

T

C

T

T

G

T

T

G

A

A

T

T

T

T

T

T

C

T

A

A

T

C

T

G

A

C

T

C

T

A

T

C

A

G

T

T

A

T

G

G

G

A

A

T

G

T

T

C

C

C

T

C

A

A

T

T

C

T

T

A

G

T

G

C

T

C

C

A

A

A

C

C

G

G

A

C

T

T

G

C

T

C

T

T

G

G

C

T

T

G

T

A

T

T

T

G

T

C

C

A

A

A

A

T

A

T

T

T

G

T

C

T

T

C

T

C

T

A

T

G

T

T

T

T

C

T

A

C

A

T

G

T

T

T

G

T

C

T

T

A

T

A

A

G

G

A

C

A

A

A

A

A

C

C

T

G

C

C

T

T

A

G

T

T

T

A

T

C

C

A

T

G

A

A

C

A

A

A

G

C

C

A

C

G

C

A

T

G

C

T

A

G

T

G

G

A

C

A

C

A

C

A

C

A

C

A

C

A

T

G

C

G

C

G

T

G

C

G

C

G

C

G

C

A

C

A

C

A

C

A

C

A

C

A

C

A

C

A

C

A

C

A

T

A

C

A

C

A

C

A

G

A

G

A

C

T

T

T

G

T

A

T

G

T

G

A

G

T

A

A

T

G

A

A

T

C

A

T

C

A

A

A

T

C

A

T

C

A

T

A

A

T

T

T

C

T

G

G

A

C

T

T

G

T

A

T

T

A

A

T

A

A

G

T

C

G

G

C

C

A

G

G

A

G

G

A

A

A

A

G

A

A

T

C

T

G

C

T

G

T

C

A

A

T

C

A

T

G

G

C

T

T

C

T

G

G

T

T

C

T

C

A

C

A

G

T

C

A

T

C

T

C

T

A

C

T

T

T

C

T

T

C

C

A

G

C

A

A

G

T

T

T

G

G

T

T

C

T

G

T

C

A

A

A

A

A

C

C

A

G

C

T

G

T

C

A

G

C

C

T

T

G

T

T

C

C

T

G

C

A

T

G

C

C

C

A

A

T

G

C

A

G

A

A

G

A

G

T

C

A

G

T

A

A

A

G

A

A

G

A

T

T

T

G

G

T

T

C

T

C

T

G

T

A

T

T

T

C

A

G

G

G

G

C

A

T

C

A

A

T

G

C

C

A

G

G

T

T

G

A

A

A

T

A

T

G

C

C

A

T

T

C

T

G

G

C

C

C

A

G

C

T

C

A

G

T

G

G

C

T

C

A

C

A

C

G

T

G

T

A

A

T

C

C

C

A

G

C

A

C

T

T

T

G

G

A

A

G

G

C

C

A

A

A

G

C

G

G

G

T

G

G

A

T

T

G

C

T

T

G

A

G

C

T

C

A

G

G

A

G

T

T

C

G

A

G

A

C

C

A

G

C

C

T

G

G

G

C

A

A

G

A

G

G

C

T

G

A

G

G

T

G

G

G

A

G

G

A

T

G

A

C

C

T

G

A

G

C

C

C

G

G

G

A

G

G

T

C

A

A

G

G

C

T

G

C

A

G

C

G

A

G

C

T

G

T

G

A

T

C

G

T

G

C

C

A

C

T

G

C

A

C

T

C

G

A

G

C

C

A

G

G

G

C

G

T

T

G

G

A

G

T

G

A

G

A

C

C

C

T

G

T

C

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

A

G

G

A

A

G

G

A

A

A

A

A

A

G

G

A

A

G

G

A

A

G

G

A

A

G

G

G

A

G

G

G

A

G

G

G

A

A

G

A

T

G

C

C

A

T

T

C

T

T

A

G

A

T

T

G

A

A

G

T

G

G

A

C

T

T

T

A

T

C

T

G

G

G

C

A

G

A

A

C

A

C

A

C

A

C

A

C

A

C

A

T

A

C

A

C

A

C

A

T

G

C

A

C

A

C

A

C

A

C

A

T

T

G

T

G

G

A

G

A

A

A

T

T

G

C

T

G

A

C

T

A

A

G

C

A

A

A

G

C

T

T

C

C

A

A

A

T

G

A

C

T

T

A

G

T

T

T

G

G

C

T

A

A

A

A

T

G

T

A

G

G

C

T

T

T

T

A

A

A

A

A

T

G

T

G

A

G

C

A

C

T

G

C

C

A

A

G

G

G

T

T

T

T

T

C

C

T

T

G

T

T

G

A

C

C

C

A

T

G

G

A

T

C

C

A

T

C

A

A

G

T

G

C

A

A

A

C

A

T

T

T

T

C

T

A

A

T

G

C

A

C

T

A

T

A

T

T

T

A

A

G

C

C

T

G

T

G

C

A

G

C

T

A

G

A

T

G

T

C

A

T

T

C

A

A

C

A

T

G

A

A

A

T

A

C

A

T

T

A

T

T

A

C

A

A

C

T

T

G

C

A

T

C

T

G

T

C

T

A

A

A

A

T

C

T

T

G

C

A

T

C

T

A

A

A

A

T

G

A

G

A

G

A

C

A

A

A

A

A

A

T

C

T

A

T

A

A

A

A

A

T

G

G

A

A

A

A

C

A

T

G

C

A

T

A

G

A

A

A

T

A

T

G

T

G

A

G

G

G

A

G

G

A

A

A

A

A

A

T

T

A

C

C

C

C

C

A

A

G

A

A

T

G

T

T

A

G

T

G

C

A

C

G

C

A

G

T

C

A

C

A

C

A

G

G

G

A

G

A

A

G

A

C

T

A

T

T

T

T

T

G

T

T

T

T

G

T

T

T

T

G

A

T

T

G

T

T

T

T

G

T

T

T

T

G

T

T

T

T

G

G

T

T

G

T

T

T

T

G

T

T

T

T

G

G

T

G

A

C

C

T

A

A

C

T

G

G

T

C

A

A

A

T

G

A

C

C

T

A

T

T

A

A

G

A

A

T

A

T

T

T

C

A

T

A

G

A

A

C

G

A

A

T

G

T

T

C

C

G

A

T

G

C

T

C

T

A

A

T

C

T

C

T

C

T

A

G

A

C

A

A

G

G

T

T

C

A

T

A

T

T

T

G

T

A

T

G

G

G

T

T

A

C

T

T

A

T

T

C

T

C

T

C

T

T

T

G

T

T

G

A

C

T

A

A

G

T

C

A

A

T

A

A

T

C

A

G

A

A

T

C

A

G

C

A

G

G

T

T

T

G

C

A

G

T

C

A

G

A

T

T

G

G

C

A

G

G

G

A

T

A

A

G

C

A

G

C

C

T

A

G

C

T

C

A

G

G

A

G

A

A

G

T

G

A

G

T

A

T

A

A

A

A

G

C

C

C

C

A

G

G

C

T

G

G

G

A

G

C

A

G

C

C

A

T

Matrix 1

Matrix 2

Sequence NM_005525.1:chr1

T

C

C

T

T

G

T

T

T

C

T

C

A

T

C

A

A

T

G

C

A

T

T

T

T

A

T

A

T

A

G

C

A

A

T

T

A

T

T

T

T

A

T

C

T

A

A

T

C

C

C

A

T

G

A

A

A

C

T

C

A

C

T

T

T

A

T

T

G

G

A

T

G

C

T

T

T

T

G

C

C

A

T

A

T

C

C

T

T

A

T

T

T

T

C

T

A

G

C

A

T

C

G

T

A

G

C

T

A

T

T

A

G

G

T

C

A

T

C

T

A

A

T

T

A

T

T

A

A

T

C

T

G

T

T

T

G

T

G

T

C

T

T

T

G

G

G

T

T

T

A

A

A

T

G

T

G

T

C

T

T

T

T

G

A

G

G

C

C

A

C

A

C

A

A

T

G

T

T

G

G

A

C

T

T

C

A

T

T

T

T

T

T

A

A

T

G

G

A

G

C

C

A

A

C

A

A

T

C

A

G

C

A

A

T

T

G

T

T

A

A

T

G

C

A

T

T

T

G

C

T

T

T

G

T

G

T

T

C

T

A

T

T

A

C

T

C

T

G

C

A

G

T

T

T

A

T

C

T

T

A

C

T

C

A

T

T

G

T

T

A

T

T

T

T

T

G

C

T

T

T

C

T

T

T

A

A

A

T

T

T

A

T

G

T

T

T

T

C

T

T

A

A

T

G

G

A

C

T

T

T

A

A

A

A

T

T

C

T

T

T

A

T

T

T

A

T

T

T

T

T

T

A

T

G

T

C

A

G

A

C

A

A

T

A

A

A

C

A

T

C

C

C

T

A

G

T

C

T

G

C

C

C

A

T

C

T

T

T

C

T

A

T

C

A

T

T

T

C

A

A

C

A

T

C

A

T

C

A

T

A

T

T

T

C

C

A

A

A

T

A

A

C

T

T

T

T

C

A

T

T

G

T

T

T

C

C

T

A

T

A

A

T

T

T

T

A

C

T

A

T

T

A

A

T

A

G

T

A

T

A

G

G

A

T

T

A

A

G

A

A

A

A

T

A

A

A

C

C

T

T

A

T

C

T

G

G

G

T

T

C

T

G

G

C

T

G

G

C

A

C

T

G

C

C

T

T

C

C

C

T

C

T

A

G

G

G

A

T

G

A

A

A

A

T

G

G

A

G

T

G

T

A

G

T

C

T

G

T

A

A

T

A

T

A

T

C

C

T

G

G

T

A

T

C

A

T

A

A

A

T

A

T

A

T

T

T

A

T

A

A

A

A

T

T

A

T

A

C

A

A

A

T

G

T

A

G

C

T

T

G

C

A

G

T

T

C

T

A

A

A

G

G

C

A

T

G

T

A

A

T

C

T

A

A

T

T

T

T

T

A

C

T

T

G

A

A

T

T

T

T

A

T

C

T

T

T

T

T

T

C

T

C

T

T

T

T

T

G

T

C

C

T

T

C

A

T

A

G

A

C

C

T

C

G

A

G

C

T

C

T

G

T

C

T

A

G

C

C

C

T

C

A

A

C

T

G

T

T

C

T

C

A

A

A

T

C

T

C

C

A

T

T

G

T

T

T

T

C

T

A

C

A

A

G

T

G

A

C

C

C

T

C

A

C

A

G

C

T

G

T

G

G

G

C

C

T

T

T

G

T

T

G

A

C

A

A

A

T

T

G

T

T

T

C

A

T

C

T

C

C

T

C

T

G

G

G

T

C

T

T

A

A

A

T

T

A

T

T

T

T

C

T

C

T

T

A

C

T

C

T

A

A

A

G

T

G

A

A

A

A

T

T

T

G

A

T

G

A

A

T

G

T

T

T

C

C

A

G

A

T

A

C

T

G

C

A

C

T

T

G

G

A

A

T

C

A

T

A

A

C

T

T

A

A

T

T

T

C

C

C

T

T

A

A

C

C

T

T

G

T

G

T

A

A

A

T

T

C

T

G

T

C

C

C

C

C

C

A

C

T

A

C

T

C

C

C

A

A

C

T

C

C

T

A

T

C

C

C

T

C

C

T

C

C

A

A

A

G

C

A

C

T

G

A

T

A

C

T

T

A

T

T

A

T

C

A

C

A

T

T

T

A

A

A

T

T

T

T

T

T

C

C

C

C

G

C

T

C

T

A

C

T

G

A

T

A

A

C

T

T

A

C

A

G

A

A

T

G

C

A

G

G

A

C

T

G

C

A

T

T

G

T

G

A

T

G

G

G

G

T

A

A

T

T

T

C

C

A

T

G

A

G

T

T

G

A

T

T

G

G

T

T

G

G

T

T

T

T

G

A

G

T

T

G

A

A

A

A

A

C

T

T

A

A

C

A

A

T

G

A

T

A

C

A

T

C

T

T

A

A

A

T

T

C

T

T

T

C

T

T

T

G

A

G

G

A

T

T

A

T

T

C

C

T

T

A

A

T

G

A

A

T

T

C

G

T

G

C

T

A

C

G

G

A

C

A

T

A

C

T

G

A

G

G

T

G

G

T

T

A

T

T

T

T

T

A

T

A

T

T

T

C

C

C

T

G

A

T

A

A

T

A

A

A

T

T

C

T

A

A

A

T

T

G

C

T

A

A

G

G

G

T

T

T

C

T

T

A

C

C

A

C

C

C

T

C

G

T

C

C

T

T

T

T

A

C

T

G

T

T

A

C

T

A

G

A

T

C

T

A

T

T

T

T

T

A

G

C

T

G

G

T

G

T

G

G

G

C

G

T

C

C

C

C

A

G

C

T

A

G

T

T

T

C

A

C

T

T

G

C

C

T

A

A

T

G

C

T

A

G

T

T

C

T

T

T

T

T

T

C

T

T

C

T

A

C

A

T

C

A

G

G

T

C

G

C

C

T

C

T

T

C

C

T

A

G

C

A

T

C

T

T

C

T

C

C

A

T

G

T

T

T

C

T

T

G

T

T

G

C

T

C

T

A

C

A

G

C

A

T

T

T

A

C

A

A

G

A

C

C

C

A

G

T

T

T

A

A

T

A

G

T

T

T

A

G

T

G

C

C

T

T

T

T

T

T

G

T

C

A

C

T

C

A

T

T

A

T

T

T

C

T

T

C

T

T

T

G

T

T

C

T

C

T

G

T

T

A

A

A

A

T

A

A

T

A

A

G

T

G

T

A

T

G

A

T

C

C

A

T

T

G

C

A

C

T

T

G

C

C

T

T

A

G

A

G

T

C

T

T

G

A

A

C

C

A

G

T

C

T

T

G

G

A

T

T

T

C

C

C

G

C

C

A

T

C

T

G

G

G

T

T

C

T

G

G

C

T

G

G

C

T

T

G

C

A

A

T

T

T

C

T

C

C

T

T

T

G

A

T

G

T

T

G

T

A

A

T

A

C

T

T

T

T

T

C

A

T

T

G

A

A

C

T

T

G

A

G

T

G

T

G

G

G

G

C

T

T

A

T

A

G

A

G

C

T

T

C

T

T

T

G

C

T

T

T

C

A

T

T

A

T

T

T

T

T

T

C

C

C

A

A

A

A

T

G

T

G

C

A

C

A

T

T

T

T

T

T

T

T

C

T

T

A

A

G

C

T

T

A

T

T

T

T

G

C

T

G

T

T

T

T

G

T

G

C

T

G

T

T

A

T

T

T

T

T

A

A

T

T

G

C

T

T

C

C

C

A

C

T

G

G

G

T

G

G

G

G

G

G

G

T

A

G

G

G

G

G

A

C

T

G

A

G

A

G

T

G

A

G

A

T

T

T

G

G

C

T

T

G

A

G

T

T

T

G

G

C

T

C

T

C

T

T

T

G

C

T

A

T

T

A

C

T

C

A

C

A

T

T

T

C

C

C

C

C

C

A

G

A

A

G

C

C

C

T

A

C

A

T

G

C

A

C

T

C

C

T

C

T

C

T

C

T

C

T

G

T

C

T

T

T

G

A

C

A

A

A

T

T

A

C

T

T

T

T

G

A

A

A

G

A

T

C

A

T

T

G

A

T

C

C

C

T

G

G

C

G

T

A

A

A

T

G

G

T

G

T

T

A

A

G

A

G

T

A

A

G

A

T

G

G

A

C

T

C

G

G

G

T

A

G

G

G

A

T

G

C

T

C

A

G

G

A

A

T

C

C

A

G

T

C

C

T

G

T

A

C

A

G

T

C

A

T

G

A

G

C

T

T

G

G

C

C

A

T

C

T

G

G

A

A

G

T

C

T

C

C

T

C

T

T

G

C

T

C

A

A

T

G

A

A

A

T

G

G

A

G

T

A

A

A

C

A

T

T

G

T

C

C

A

T

T

A

T

G

A

A

A

T

C

C

A

C

C

A

C

A

C

A

G

G

C

T

G

C

C

A

G

G

G

A

C

G

A

A

T

G

G

G

A

T

C

C

C

A

C

C

C

A

A

A

G

C

C

A

A

T

C

G

C

T

G

C

T

C

T

G

A

C

A

G

G

G

A

A

A

T

T

G

G

C

T

A

G

C

A

C

T

G

C

C

T

G

A

G

A

C

T

A

C

T

C

C

A

G

C

C

T

C

C

C

C

C

G

T

C

C

C

T

G

A

T

G

T

C

A

C

Matrix 1

Matrix 2