RID=1047300579-025604-27783, hg13_dna|geneid_v1.1_predicted_protein_2|1064

BLASTP 2.2.5 [Nov-16-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402.
RID: 1047300579-025604-27783
Query= hg13_dna|geneid_v1.1_predicted_protein_2|1064_AA (1063 letters)
Database: All non-redundant GenBank CDS translations+PDB+SwissProt+PIR+PRF 2,518,611 sequences; 813,738,281 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Taxonomy reports
Distribution of 103 Blast Hits on the Query Sequence

Related Structures

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5689521|dbj|BAA83044.1|  KIAA1092 protein [Homo sapiens]      2044   0.0   
gi|20379605|gb|AAH27746.1|  phospholipase C-like 2 [Mus musc...  2008   0.0   
gi|20900305|ref|XP_128631.1|  similar to phospholipase C-lik...  2006   0.0   
gi|6705987|dbj|BAA89457.1|  phospholipase C-L2 [Mus musculus]    1996   0.0   
gi|22137761|gb|AAH36392.1|  phospholipase C-like 2 [Homo sap...  1991   0.0   
gi|24308011|ref|NP_055999.1|  phospholipase C-like 2; phosph...  1991   0.0   
gi|1183844|dbj|BAA08351.1|  130kDa-Ins(1,4,5)P3 binding prot...  1347   0.0   
gi|2143804|pir||S62358  inositol 1,4,5-trisphosphate-binding...  1347   0.0   
gi|16758196|ref|NP_445908.1|  130kDa-Ins(1,4,5)P3 binding pr...  1347   0.0   
gi|10435513|dbj|BAB14606.1|  unnamed protein product [Homo s...  1327   0.0   
gi|780122|dbj|BAA07688.1|  Phospholipase C [Homo sapiens]        1323   0.0   
gi|2135919|pir||I54390  phosphoinositide-specific phospholip...  1323   0.0   
gi|5453912|ref|NP_006217.1|  phospholipase C-like 1; phospho...  1323   0.0   
gi|25144969|ref|NP_741068.1|  Phospholipase C (121.1 kD) [Ca...   737   0.0   
gi|25112181|gb|AAN72422.1|  Hypothetical protein K10F12.3a [...   737   0.0   
gi|25144971|ref|NP_741067.1|  Phospholipase C-L2 (120.0 kD) ...   735   0.0   
gi|25112182|gb|AAN72423.1|  Hypothetical protein K10F12.3b [...   735   0.0   
gi|7505734|pir||T32374  hypothetical protein K10F12.3 - Caen...   704   0.0   
gi|17554140|ref|NP_497191.1|  phospholipase C [Caenorhabditi...   704   0.0   
gi|28478991|ref|XP_129785.2|  similar to 130kDa-Ins(1,4,5)P3...   641   0.0   
gi|13623501|gb|AAH06355.1|AAH06355  Unknown (protein for MGC...   477   e-133 
gi|14249340|ref|NP_116115.1|  phospholipase C, delta 4; PLC ...   477   e-133 
gi|20269957|gb|AAM18122.1|AF498759_1  phospholipase C delta ...   470   e-130 
gi|108854|pir||S14113  1-phosphatidylinositol-4,5-bisphospha...   468   e-130 
gi|206220|gb|AAA41886.1|  phospholipase C-III                     462   e-128 
gi|91898|pir||B28821  1-phosphatidylinositol-4,5-bisphosphat...   462   e-128 
gi|130228|sp|P10688|PID1_RAT  1-phosphatidylinositol-4,5-bis...   462   e-128 
gi|8393981|ref|NP_058731.1|  phospholipase C, delta 1; Phosp...   462   e-128 
gi|4099291|gb|AAD00570.1|  phospholipase C delta-1; PI-PLC-d...   454   e-126 
gi|4894788|gb|AAD32616.1|AF133125_1  phospholipase C delta-1...   454   e-126 
gi|26324684|dbj|BAC26096.1|  unnamed protein product [Mus mu...   454   e-126 
gi|26350063|dbj|BAC38671.1|  unnamed protein product [Mus mu...   454   e-126 
gi|9790167|ref|NP_062650.1|  phospholipase C, delta; PLC-del...   454   e-126 
gi|23396799|sp|Q8R3B1|PID1_MOUSE  1-phosphatidylinositol-4,5...   454   e-126 
gi|19387967|gb|AAH25798.1|  phospholipase C, delta [Mus musc...   454   e-126 
gi|1245472|gb|AAA93481.1|  phospholipase C-delta1                 452   e-125 
gi|2137061|pir||PC4183  1-phosphatidylinositol-4,5-bisphosph...   452   e-125 
gi|1587358|prf||2206431A  phospholipase C-delta4                  451   e-125 
gi|571466|gb|AAC52346.1|  phospholipase C delta-4                 451   e-125 
gi|18093100|ref|NP_542419.1|  phospholipase C, delta 4 [Ratt...   451   e-125 
gi|1304189|dbj|BAA09046.1|  phodpholipase C delta4 [Rattus n...   449   e-124 
gi|1150520|emb|CAA89822.1|  phospholipase C [Oryctolagus cun...   445   e-123 
gi|89332|pir||C28821  1-phosphatidylinositol-4,5-bisphosphat...   437   e-121 
gi|163538|gb|AAA30710.1|  phospholipase C-III                     436   e-120 
gi|130227|sp|P10895|PID1_BOVIN  1-phosphatidylinositol-4,5-b...   436   e-120 
gi|483920|gb|AAA73567.1|  phospholipase c delta 1                 432   e-119 
gi|1082691|pir||A55943  1-phosphatidylinositol-4,5-bisphosph...   432   e-119 
gi|1730575|sp|P51178|PID1_HUMAN  1-phosphatidylinositol-4,5-...   432   e-119 
gi|5453910|ref|NP_006216.1|  phospholipase C, delta 1 [Homo ...   432   e-119 
gi|21740077|emb|CAD39054.1|  hypothetical protein [Homo sapi...   427   e-118 
gi|18676791|dbj|BAB85029.1|  unnamed protein product [Homo s...   427   e-118 
gi|19115964|ref|NP_588614.1|  similar to phospholipase C, de...   427   e-118 
gi|18916814|dbj|BAB85550.1|  KIAA1964 protein [Homo sapiens]      427   e-117 
gi|22779905|ref|NP_690026.1|  RIKEN cDNA 2610205J15 [Mus mus...   419   e-115 
gi|21595117|gb|AAH31392.1|  RIKEN cDNA 2610205J15 gene [Mus ...   419   e-115 
gi|26338287|dbj|BAC32829.1|  unnamed protein product [Mus mu...   417   e-115 
gi|2392267|pdb|1DJG|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392268|pdb|1DJG|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392269|pdb|1DJH|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392270|pdb|1DJH|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392271|pdb|1DJI|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392272|pdb|1DJI|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392273|pdb|1DJW|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392274|pdb|1DJW|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392275|pdb|1DJX|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392276|pdb|1DJX|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392277|pdb|1DJY|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392278|pdb|1DJY|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392279|pdb|1DJZ|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392280|pdb|1DJZ|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392700|pdb|2ISD|A  Chain A, Phosphoinositide-Specific Ph...   414   e-114 
gi|2392701|pdb|2ISD|B  Chain B, Phosphoinositide-Specific Ph...   414   e-114 
gi|1942317|pdb|1QAS|A  Chain A, 1-Phosphatidylinositol-4,5-B...   414   e-114 
gi|1942318|pdb|1QAS|B  Chain B, 1-Phosphatidylinositol-4,5-B...   414   e-114 
gi|1942319|pdb|1QAT|A  Chain A, 1-Phosphatidylinositol-4,5-B...   414   e-114 
gi|1942320|pdb|1QAT|B  Chain B, 1-Phosphatidylinositol-4,5-B...   414   e-114 
gi|25053795|gb|AAN71895.1|  PLC-zeta [Homo sapiens]               414   e-114 
gi|25188201|ref|NP_149114.2|  phospholipase C, zeta 1; testi...   414   e-114 
gi|7512642|pir||T17284  hypothetical protein DKFZp434L0735.1...   406   e-111 
gi|5912030|emb|CAB55974.1|  hypothetical protein [Homo sapiens]   406   e-111 
gi|1584770|prf||2123392A  phosphoinositide-specific phosphol...   404   e-110 
gi|1195552|gb|AAA87954.1|  phosphoinositide-specific phospho...   403   e-110 
gi|14715017|gb|AAH10668.1|AAH10668  Similar to phospholipase...   399   e-109 
gi|22347519|gb|AAM95914.1|AF435950_1  PLC-zeta [Mus musculus]     392   e-107 
gi|22550102|ref|NP_473407.2|  phospholipase C, zeta 1; phosp...   392   e-107 
gi|14517327|gb|AAK61372.1|  testis-development related NYD-S...   386   e-105 
gi|4521179|dbj|BAA76278.1|  PLC-deltaH [Hydra magnipapillata]     380   e-103 
gi|26336645|dbj|BAC32005.1|  unnamed protein product [Mus mu...   352   3e-95 
gi|27673527|ref|XP_217326.1|  similar to phospholipase C-lik...   349   2e-94 
gi|26340698|dbj|BAC34011.1|  unnamed protein product [Mus mu...   348   5e-94 
gi|27663526|ref|XP_233728.1|  similar to Hypothetical protei...   336   2e-90 
gi|4521175|dbj|BAA76276.1|  PLC-betaH1 [Hydra magnipapillata]     320   1e-85 
gi|28273134|dbj|BAC56930.1|  FLJ00414 protein [Homo sapiens]      316   2e-84 
gi|1583603|prf||2121280A  phosphatidylinositol specific phos...   297   1e-78 
gi|2146891|pir||S66672  phosphatidylinositol-specific phosph...   297   1e-78 
gi|439519|emb|CAA54275.1|  Phosphatidylinositol-specific Pho...   297   1e-78 
gi|27477726|ref|XP_042635.3|  similar to KIAA1069 protein [H...   292   4e-77 
gi|10336516|dbj|BAB13760.1|  phospholipase C [Watasenia scin...   289   3e-76 
gi|21288669|gb|EAA00962.1|  ebiP7901 [Anopheles gambiae str....   289   3e-76 
gi|21757361|dbj|BAC05099.1|  unnamed protein product [Homo s...   287   1e-75 

Alignments


>gi|5689521|dbj|BAA83044.1|   KIAA1092 protein [Homo sapiens]
          Length = 1154

 Score = 2044 bits (5295), Expect = 0.0
 Identities = 995/1047 (95%), Positives = 995/1047 (95%), Gaps = 28/1047 (2%)

Query: 17   KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD 76
            KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD
Sbjct: 136  KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD 195

Query: 77   MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYES 136
            MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYES
Sbjct: 196  MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYES 255

Query: 137  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHIT 196
            LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHIT
Sbjct: 256  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHIT 315

Query: 197  LCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLL 256
            LCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLL
Sbjct: 316  LCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLL 375

Query: 257  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 316
            VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY
Sbjct: 376  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 435

Query: 317  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 376
            LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR
Sbjct: 436  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 495

Query: 377  SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXX 436
            SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI   
Sbjct: 496  SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQ 555

Query: 437  XXXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDE 496
                     LLGDKLYTTSPNVEESYLPSPDV            SSNCSGVEGDVTDEDE
Sbjct: 556  KVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDE 615

Query: 497  GAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 556
            GAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF
Sbjct: 616  GAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 675

Query: 557  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 616
            NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG
Sbjct: 676  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 735

Query: 617  LMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 676
            LMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK
Sbjct: 736  LMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 795

Query: 677  PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVR 736
            PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVR
Sbjct: 796  PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVR 855

Query: 737  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 796
            FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK
Sbjct: 856  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 915

Query: 797  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 856
            PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC
Sbjct: 916  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 975

Query: 857  GLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSM 916
            GLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM  
Sbjct: 976  GLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM-- 1033

Query: 917  ITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK 976
                             MIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK
Sbjct: 1034 -----------------MIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK 1076

Query: 977  ERKLQKAVESFTWNITILKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1036
            ERKLQKAVESFTWNITILK         GQADLLKYAKNETLENLKQIHFAAVSCGLNKP
Sbjct: 1077 ERKLQKAVESFTWNITILK---------GQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1127

Query: 1037 GTENADVQKPRRSLEVIPEKANDETGE 1063
            GTENADVQKPRRSLEVIPEKANDETGE
Sbjct: 1128 GTENADVQKPRRSLEVIPEKANDETGE 1154



>gi|20379605|gb|AAH27746.1|   phospholipase C-like 2 [Mus musculus]
          Length = 1128

 Score = 2008 bits (5201), Expect = 0.0
 Identities = 974/1047 (93%), Positives = 988/1047 (94%), Gaps = 28/1047 (2%)

Query: 17   KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD 76
            KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD
Sbjct: 110  KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD 169

Query: 77   MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYES 136
            MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGIS+QISEDCAFSVIYGENYES
Sbjct: 170  MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYES 229

Query: 137  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHIT 196
            LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVD LGHIT
Sbjct: 230  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDGLGHIT 289

Query: 197  LCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLL 256
            LC+AVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTE+TKEEFIEVFHELCTRPEIYFLL
Sbjct: 290  LCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTRPEIYFLL 349

Query: 257  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 316
            VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY
Sbjct: 350  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 409

Query: 317  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 376
            LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR
Sbjct: 410  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 469

Query: 377  SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXX 436
            SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI   
Sbjct: 470  SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQ 529

Query: 437  XXXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDE 496
                     +LGDKLYTTSPN+EESYLPSPDV            SSNCSGVEGDVTDEDE
Sbjct: 530  KVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDE 589

Query: 497  GAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 556
            GAEMSQRMGKEN+EQPN+VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF
Sbjct: 590  GAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 649

Query: 557  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 616
            NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG
Sbjct: 650  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 709

Query: 617  LMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 676
            LMMDLN+GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK
Sbjct: 710  LMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 769

Query: 677  PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVR 736
            PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTV+QNGDAPIFDESFEFQINLPELAMVR
Sbjct: 770  PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVR 829

Query: 737  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 796
            FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK
Sbjct: 830  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 889

Query: 797  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 856
            PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC
Sbjct: 890  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 949

Query: 857  GLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSM 916
            GLSSVANLMQCMLAVSPRFLGPDN PLVVLNLSE YPTMELQ IVPEVLKKIVTTYDM  
Sbjct: 950  GLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDM-- 1007

Query: 917  ITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK 976
                             M+QSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK
Sbjct: 1008 -----------------MMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK 1050

Query: 977  ERKLQKAVESFTWNITILKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1036
            ERKLQKAVESFTWNITILK         GQADLLKYAKNETLENLKQIHFAAVSCGLNKP
Sbjct: 1051 ERKLQKAVESFTWNITILK---------GQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1101

Query: 1037 GTENADVQKPRRSLEVIPEKANDETGE 1063
            GTEN++ QKPRRSLE IPEKA+DE G+
Sbjct: 1102 GTENSEAQKPRRSLEAIPEKASDENGD 1128



>gi|20900305|ref|XP_128631.1|   similar to phospholipase C-like 2 [Mus musculus]
          Length = 1128

 Score = 2006 bits (5196), Expect = 0.0
 Identities = 972/1047 (92%), Positives = 987/1047 (94%), Gaps = 28/1047 (2%)

Query: 17   KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD 76
            KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD
Sbjct: 110  KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD 169

Query: 77   MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYES 136
            MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGIS+QISEDCAFSVIYGENYES
Sbjct: 170  MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYES 229

Query: 137  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHIT 196
            LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSW+SQMFSEIDVD LGHIT
Sbjct: 230  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHIT 289

Query: 197  LCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLL 256
            LC+AVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTE+TKEEFIEVFHELCTRPEIYFLL
Sbjct: 290  LCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELCTRPEIYFLL 349

Query: 257  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 316
            VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY
Sbjct: 350  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 409

Query: 317  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 376
            LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR
Sbjct: 410  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 469

Query: 377  SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXX 436
            SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI   
Sbjct: 470  SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQ 529

Query: 437  XXXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDE 496
                     +LGDKLYTTSPN+EESYLPSPDV            SSNCSGVEGDVTDEDE
Sbjct: 530  KVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDE 589

Query: 497  GAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 556
            GAEMSQRMGKEN+EQPN+VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF
Sbjct: 590  GAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 649

Query: 557  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 616
            NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG
Sbjct: 650  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 709

Query: 617  LMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 676
            LMMDLN+GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK
Sbjct: 710  LMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 769

Query: 677  PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVR 736
            PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTV+QNGDAPIFDESFEFQINLPELAMVR
Sbjct: 770  PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDAPIFDESFEFQINLPELAMVR 829

Query: 737  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 796
            FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK
Sbjct: 830  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 889

Query: 797  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 856
            PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC
Sbjct: 890  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 949

Query: 857  GLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSM 916
            GLSSVANLMQCMLAVSPRFLGPDN PLVVLNLSE YPTMELQ IVPEVLKKIVTTYDM  
Sbjct: 950  GLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDM-- 1007

Query: 917  ITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK 976
                             M+QSLKALIENADAVYEKIVHC KAAMEFHEHLHSIGTKEGLK
Sbjct: 1008 -----------------MMQSLKALIENADAVYEKIVHCHKAAMEFHEHLHSIGTKEGLK 1050

Query: 977  ERKLQKAVESFTWNITILKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1036
            ERKLQKAVESFTWNITILK         GQADLLKYAKNETLENLKQIHFAAVSCGLNKP
Sbjct: 1051 ERKLQKAVESFTWNITILK---------GQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1101

Query: 1037 GTENADVQKPRRSLEVIPEKANDETGE 1063
            GTEN++ QKPRRSLE IPEKA+DE G+
Sbjct: 1102 GTENSEAQKPRRSLEAIPEKASDENGD 1128



>gi|6705987|dbj|BAA89457.1|   phospholipase C-L2 [Mus musculus]
          Length = 1128

 Score = 1996 bits (5172), Expect = 0.0
 Identities = 968/1047 (92%), Positives = 985/1047 (94%), Gaps = 28/1047 (2%)

Query: 17   KDGTKQKRERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDAD 76
            KDGTKQKRERKKTVSFSSMPTEKKISSASDCI+SMVEGSELKKVRSNSRIYHRYFLLDAD
Sbjct: 110  KDGTKQKRERKKTVSFSSMPTEKKISSASDCIHSMVEGSELKKVRSNSRIYHRYFLLDAD 169

Query: 77   MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYES 136
            MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGIS+QISEDCAFSVIYGENYES
Sbjct: 170  MQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYES 229

Query: 137  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHIT 196
            LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSW+SQMFSEIDVD LGHIT
Sbjct: 230  LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWISQMFSEIDVDGLGHIT 289

Query: 197  LCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLL 256
            LC+AVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTE+TKEEFIEVFHEL TRPEIYFLL
Sbjct: 290  LCHAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEITKEEFIEVFHELRTRPEIYFLL 349

Query: 257  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 316
            VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY
Sbjct: 350  VQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNY 409

Query: 317  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 376
            LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR
Sbjct: 410  LMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCR 469

Query: 377  SVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXX 436
            SVELDVWDGPDNEPV+YTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI   
Sbjct: 470  SVELDVWDGPDNEPVVYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQ 529

Query: 437  XXXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDE 496
                     +LGDKLYTTSPN+EESYLPSPDV            SSNCSGVEGDVTDEDE
Sbjct: 530  KVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDE 589

Query: 497  GAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 556
            GAEMSQRMGKEN+EQPN+VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF
Sbjct: 590  GAEMSQRMGKENVEQPNHVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSF 649

Query: 557  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 616
            NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG
Sbjct: 650  NEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPG 709

Query: 617  LMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 676
            LMMDLN+GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK
Sbjct: 710  LMMDLNVGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPK 769

Query: 677  PKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVR 736
            PKGSGAKGDVVDPYVYVEIHGIPADCA  RTKTV+QNGDAPIFDESFEFQINLPELAMVR
Sbjct: 770  PKGSGAKGDVVDPYVYVEIHGIPADCAADRTKTVNQNGDAPIFDESFEFQINLPELAMVR 829

Query: 737  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 796
            FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK
Sbjct: 830  FVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGK 889

Query: 797  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 856
            PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC
Sbjct: 890  PHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELC 949

Query: 857  GLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSM 916
            GLSSVANLMQCMLAVSPRFLGPDN PLVVLNLSE YPTMELQ IVPEVLKKIVTTYDM  
Sbjct: 950  GLSSVANLMQCMLAVSPRFLGPDNNPLVVLNLSEPYPTMELQAIVPEVLKKIVTTYDM-- 1007

Query: 917  ITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK 976
                             M+QSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK
Sbjct: 1008 -----------------MMQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLK 1050

Query: 977  ERKLQKAVESFTWNITILKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1036
            ERKLQKAVESFTWNITILK         GQADLLKYAKNETLENLKQIHFAAVSCGLNKP
Sbjct: 1051 ERKLQKAVESFTWNITILK---------GQADLLKYAKNETLENLKQIHFAAVSCGLNKP 1101

Query: 1037 GTENADVQKPRRSLEVIPEKANDETGE 1063
            GTEN++ QKPRRSLE IPEKA+DE G+
Sbjct: 1102 GTENSEAQKPRRSLEAIPEKASDENGD 1128



>gi|22137761|gb|AAH36392.1|   phospholipase C-like 2 [Homo sapiens]
          Length = 1001

 Score = 1991 bits (5158), Expect = 0.0
 Identities = 972/1029 (94%), Positives = 974/1029 (94%), Gaps = 28/1029 (2%)

Query: 35   MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 94
            MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI
Sbjct: 1    MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60

Query: 95   DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 154
            DIKSIKEVRTGKNTDIFRSNGISD+ISEDCAFSVIYGENYESLDLVANSADVANIWVTGL
Sbjct: 61   DIKSIKEVRTGKNTDIFRSNGISDRISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120

Query: 155  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 214
            RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS
Sbjct: 121  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180

Query: 215  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 274
            KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF
Sbjct: 181  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240

Query: 275  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 334
            LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ
Sbjct: 241  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300

Query: 335  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 394
            DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT
Sbjct: 301  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360

Query: 395  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTT 454
            GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI            LLGDKLYTT
Sbjct: 361  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420

Query: 455  SPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 514
            SPNVEESYLPSPDV            SSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN
Sbjct: 421  SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 480

Query: 515  VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 574
            VPVKRFQLCKELSELVSICKSVQFKEFQ+SFQVQKYWEVCSFNEVLASKYANENPGDFVN
Sbjct: 481  VPVKRFQLCKELSELVSICKSVQFKEFQMSFQVQKYWEVCSFNEVLASKYANENPGDFVN 540

Query: 575  YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 634
            YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY
Sbjct: 541  YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 600

Query: 635  VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 694
            VLRPAIMREEVSFFS NTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE
Sbjct: 601  VLRPAIMREEVSFFSVNTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 660

Query: 695  IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 754
            IHGIPADCAEQRTKTVHQNGDA IFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT
Sbjct: 661  IHGIPADCAEQRTKTVHQNGDAHIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 720

Query: 755  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 814
            IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKP KRGLSVRKGKKSREYA
Sbjct: 721  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPRKRGLSVRKGKKSREYA 780

Query: 815  SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 874
            SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR
Sbjct: 781  SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 840

Query: 875  FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQKM 934
            FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM                   M
Sbjct: 841  FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM-------------------M 881

Query: 935  IQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITIL 994
            IQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITIL
Sbjct: 882  IQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITIL 941

Query: 995  KVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIP 1054
            K         GQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIP
Sbjct: 942  K---------GQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIP 992

Query: 1055 EKANDETGE 1063
            EKANDETGE
Sbjct: 993  EKANDETGE 1001



>gi|24308011|ref|NP_055999.1|   phospholipase C-like 2; phospholipase C, epsilon 2 [Homo sapiens]
          Length = 1001

 Score = 1991 bits (5158), Expect = 0.0
 Identities = 972/1029 (94%), Positives = 974/1029 (94%), Gaps = 28/1029 (2%)

Query: 35   MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 94
            MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI
Sbjct: 1    MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60

Query: 95   DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 154
            DIKSIKEVRTGKNTDIFRSNGISD+ISEDCAFSVIYGENYESLDLVANSADVANIWVTGL
Sbjct: 61   DIKSIKEVRTGKNTDIFRSNGISDRISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120

Query: 155  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 214
            RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS
Sbjct: 121  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180

Query: 215  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 274
            KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF
Sbjct: 181  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240

Query: 275  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 334
            LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ
Sbjct: 241  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300

Query: 335  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 394
            DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT
Sbjct: 301  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360

Query: 395  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTT 454
            GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI            LLGDKLYTT
Sbjct: 361  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420

Query: 455  SPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 514
            SPNVEESYLPSPDV            SSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN
Sbjct: 421  SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 480

Query: 515  VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 574
            VPVKRFQLCKELSELVSICKSVQFKEFQ+SFQVQKYWEVCSFNEVLASKYANENPGDFVN
Sbjct: 481  VPVKRFQLCKELSELVSICKSVQFKEFQMSFQVQKYWEVCSFNEVLASKYANENPGDFVN 540

Query: 575  YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 634
            YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY
Sbjct: 541  YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 600

Query: 635  VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 694
            VLRPAIMREEVSFFS NTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE
Sbjct: 601  VLRPAIMREEVSFFSVNTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 660

Query: 695  IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 754
            IHGIPADCAEQRTKTVHQNGDA IFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT
Sbjct: 661  IHGIPADCAEQRTKTVHQNGDAHIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 720

Query: 755  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 814
            IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKP KRGLSVRKGKKSREYA
Sbjct: 721  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPRKRGLSVRKGKKSREYA 780

Query: 815  SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 874
            SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR
Sbjct: 781  SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 840

Query: 875  FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQKM 934
            FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM                   M
Sbjct: 841  FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM-------------------M 881

Query: 935  IQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITIL 994
            IQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITIL
Sbjct: 882  IQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITIL 941

Query: 995  KVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIP 1054
            K         GQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIP
Sbjct: 942  K---------GQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIP 992

Query: 1055 EKANDETGE 1063
            EKANDETGE
Sbjct: 993  EKANDETGE 1001



>gi|1183844|dbj|BAA08351.1|   130kDa-Ins(1,4,5)P3 binding protein [Rattus norvegicus]
          Length = 1096

 Score = 1347 bits (3487), Expect = 0.0
 Identities = 661/1046 (63%), Positives = 798/1046 (76%), Gaps = 37/1046 (3%)

Query: 17   KDGTKQK-RERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDA 75
            KD + QK   RKKTVSFSSMP+EKKISSA DCI+ M  G ELKKVR NSRIY+R+F LD 
Sbjct: 81   KDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDT 140

Query: 76   DMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYE 135
            D+Q+LRWEPSKKD EKAK+DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYE
Sbjct: 141  DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYE 200

Query: 136  SLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHI 195
            SLDLVANSADVANIWV+GLRYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +
Sbjct: 201  SLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIM 260

Query: 196  TLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFL 255
                +V+ I+ LNP LK SKI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFL
Sbjct: 261  LEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFL 320

Query: 256  LVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTN 315
            LVQ S NKE+LD  DLM+FLE EQGV H+ E++ L+II +YE S++G++KG+L+IDGFT 
Sbjct: 321  LVQISKNKEYLDANDLMLFLEVEQGVTHVTEDMCLDIIRRYELSEDGRQKGFLAIDGFTQ 380

Query: 316  YLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGC 375
            YL+SP+C IFDPE KKV QDM QPLSHY+IN+SHNTYLIEDQFRGP+DI GY+RALKMGC
Sbjct: 381  YLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGC 440

Query: 376  RSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXX 435
            RS+ELDV DGPDNEP++   + M   + FRSV+++INK+AF ASEYPLILCL NHCS+  
Sbjct: 441  RSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQ 500

Query: 436  XXXXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                      + G+KLYT +P   ESYLPSP+              S    +EG+VTDED
Sbjct: 501  QRVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLPSESDLLEGEVTDED 560

Query: 496  EGAEMSQRM-GKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVC 554
            E AEMS+R+ G  N EQ      K   LC+ELS+LVSICKSVQ+++F++S + Q YWE+C
Sbjct: 561  EEAEMSRRVSGDYNGEQ------KHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEIC 614

Query: 555  SFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQT 614
            SF+E LAS+ ANE P DFVNYNK+FL+RV+PS MRIDSSN+NPQDFW CGCQIVAMNFQT
Sbjct: 615  SFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQT 674

Query: 615  PGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNF 674
            PG MMDL+ GWF QNG CGYVLRP+IMR+EVS+FSANTK  VPGVSP LLHIKIISGQNF
Sbjct: 675  PGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNF 734

Query: 675  PKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAM 734
            PKPKG+ AKGDV+DPYV VEIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPEL M
Sbjct: 735  PKPKGACAKGDVIDPYVCVEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELTM 794

Query: 735  VRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGG 794
            VRFV+LDDDYIGDEFIGQYTIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GG
Sbjct: 795  VRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGG 854

Query: 795  GKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKE 854
            GK  KR LSVR GKK REY  LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KE
Sbjct: 855  GKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKE 914

Query: 855  LCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM 914
            LCGL  +A+L QC+L +S R +  D+TP V L + + +P +E  G +P+V K+++  YD+
Sbjct: 915  LCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGTIPDVQKRMLAAYDL 974

Query: 915  SMITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEG 974
                               MIQ  + LIE AD V EKIV CQKA MEFHE LH++G KEG
Sbjct: 975  -------------------MIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEG 1015

Query: 975  LKERKLQKAVESFTWNITILKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLN 1034
            LK RKL KA+ESF WNIT+LK         GQ DLLK AKNE +EN+KQI  A +SCGL+
Sbjct: 1016 LKGRKLNKAIESFAWNITVLK---------GQGDLLKNAKNEAVENIKQIQLACLSCGLS 1066

Query: 1035 KPGTENADVQKPRRSLEVIPEKANDE 1060
            K G  +A   K +RSLE I EK + E
Sbjct: 1067 K-GPGSAAEAKGKRSLEAIEEKESSE 1091



>gi|2143804|pir||S62358   inositol 1,4,5-trisphosphate-binding protein, 130K - rat
          Length = 1096

 Score = 1347 bits (3487), Expect = 0.0
 Identities = 661/1046 (63%), Positives = 798/1046 (76%), Gaps = 37/1046 (3%)

Query: 17   KDGTKQK-RERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDA 75
            KD + QK   RKKTVSFSSMP+EKKISSA DCI+ M  G ELKKVR NSRIY+R+F LD 
Sbjct: 81   KDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDT 140

Query: 76   DMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYE 135
            D+Q+LRWEPSKKD EKAK+DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYE
Sbjct: 141  DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYE 200

Query: 136  SLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHI 195
            SLDLVANSADVANIWV+GLRYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +
Sbjct: 201  SLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIM 260

Query: 196  TLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFL 255
                +V+ I+ LNP LK SKI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFL
Sbjct: 261  LEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFL 320

Query: 256  LVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTN 315
            LVQ S NKE+LD  DLM+FLE EQGV H+ E++ L+II +YE S++G++KG+L+IDGFT 
Sbjct: 321  LVQISKNKEYLDANDLMLFLEVEQGVTHVTEDMCLDIIRRYELSEDGRQKGFLAIDGFTQ 380

Query: 316  YLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGC 375
            YL+SP+C IFDPE KKV QDM QPLSHY+IN+SHNTYLIEDQFRGP+DI GY+RALKMGC
Sbjct: 381  YLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGC 440

Query: 376  RSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXX 435
            RS+ELDV DGPDNEP++   + M   + FRSV+++INK+AF ASEYPLILCL NHCS+  
Sbjct: 441  RSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQ 500

Query: 436  XXXXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                      + G+KLYT +P   ESYLPSP+              S    +EG+VTDED
Sbjct: 501  QRVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLPSESDLLEGEVTDED 560

Query: 496  EGAEMSQRM-GKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVC 554
            E AEMS+R+ G  N EQ      K   LC+ELS+LVSICKSVQ+++F++S + Q YWE+C
Sbjct: 561  EEAEMSRRVSGDYNGEQ------KHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEIC 614

Query: 555  SFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQT 614
            SF+E LAS+ ANE P DFVNYNK+FL+RV+PS MRIDSSN+NPQDFW CGCQIVAMNFQT
Sbjct: 615  SFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQT 674

Query: 615  PGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNF 674
            PG MMDL+ GWF QNG CGYVLRP+IMR+EVS+FSANTK  VPGVSP LLHIKIISGQNF
Sbjct: 675  PGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNF 734

Query: 675  PKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAM 734
            PKPKG+ AKGDV+DPYV VEIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPEL M
Sbjct: 735  PKPKGACAKGDVIDPYVCVEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELTM 794

Query: 735  VRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGG 794
            VRFV+LDDDYIGDEFIGQYTIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GG
Sbjct: 795  VRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGG 854

Query: 795  GKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKE 854
            GK  KR LSVR GKK REY  LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KE
Sbjct: 855  GKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKE 914

Query: 855  LCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM 914
            LCGL  +A+L QC+L +S R +  D+TP V L + + +P +E  G +P+V K+++  YD+
Sbjct: 915  LCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGTIPDVQKRMLAAYDL 974

Query: 915  SMITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEG 974
                               MIQ  + LIE AD V EKIV CQKA MEFHE LH++G KEG
Sbjct: 975  -------------------MIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEG 1015

Query: 975  LKERKLQKAVESFTWNITILKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLN 1034
            LK RKL KA+ESF WNIT+LK         GQ DLLK AKNE +EN+KQI  A +SCGL+
Sbjct: 1016 LKGRKLNKAIESFAWNITVLK---------GQGDLLKNAKNEAVENIKQIQLACLSCGLS 1066

Query: 1035 KPGTENADVQKPRRSLEVIPEKANDE 1060
            K G  +A   K +RSLE I EK + E
Sbjct: 1067 K-GPGSAAEAKGKRSLEAIEEKESSE 1091



>gi|16758196|ref|NP_445908.1|   130kDa-Ins(1,4,5)P3 binding protein [Rattus norvegicus]
          Length = 1096

 Score = 1347 bits (3487), Expect = 0.0
 Identities = 661/1046 (63%), Positives = 798/1046 (76%), Gaps = 37/1046 (3%)

Query: 17   KDGTKQK-RERKKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDA 75
            KD + QK   RKKTVSFSSMP+EKKISSA DCI+ M  G ELKKVR NSRIY+R+F LD 
Sbjct: 81   KDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDT 140

Query: 76   DMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYE 135
            D+Q+LRWEPSKKD EKAK+DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYE
Sbjct: 141  DLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYE 200

Query: 136  SLDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHI 195
            SLDLVANSADVANIWV+GLRYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +
Sbjct: 201  SLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIM 260

Query: 196  TLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFL 255
                +V+ I+ LNP LK SKI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFL
Sbjct: 261  LEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFL 320

Query: 256  LVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTN 315
            LVQ S NKE+LD  DLM+FLE EQGV H+ E++ L+II +YE S++G++KG+L+IDGFT 
Sbjct: 321  LVQISKNKEYLDANDLMLFLEVEQGVTHVTEDMCLDIIRRYELSEDGRQKGFLAIDGFTQ 380

Query: 316  YLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGC 375
            YL+SP+C IFDPE KKV QDM QPLSHY+IN+SHNTYLIEDQFRGP+DI GY+RALKMGC
Sbjct: 381  YLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGC 440

Query: 376  RSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXX 435
            RS+ELDV DGPDNEP++   + M   + FRSV+++INK+AF ASEYPLILCL NHCS+  
Sbjct: 441  RSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQ 500

Query: 436  XXXXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                      + G+KLYT +P   ESYLPSP+              S    +EG+VTDED
Sbjct: 501  QRVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLPSESDLLEGEVTDED 560

Query: 496  EGAEMSQRM-GKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVC 554
            E AEMS+R+ G  N EQ      K   LC+ELS+LVSICKSVQ+++F++S + Q YWE+C
Sbjct: 561  EEAEMSRRVSGDYNGEQ------KHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEIC 614

Query: 555  SFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQT 614
            SF+E LAS+ ANE P DFVNYNK+FL+RV+PS MRIDSSN+NPQDFW CGCQIVAMNFQT
Sbjct: 615  SFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQT 674

Query: 615  PGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNF 674
            PG MMDL+ GWF QNG CGYVLRP+IMR+EVS+FSANTK  VPGVSP LLHIKIISGQNF
Sbjct: 675  PGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNF 734

Query: 675  PKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAM 734
            PKPKG+ AKGDV+DPYV VEIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPEL M
Sbjct: 735  PKPKGACAKGDVIDPYVCVEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELTM 794

Query: 735  VRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGG 794
            VRFV+LDDDYIGDEFIGQYTIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GG
Sbjct: 795  VRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGG 854

Query: 795  GKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKE 854
            GK  KR LSVR GKK REY  LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KE
Sbjct: 855  GKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKE 914

Query: 855  LCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM 914
            LCGL  +A+L QC+L +S R +  D+TP V L + + +P +E  G +P+V K+++  YD+
Sbjct: 915  LCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGTIPDVQKRMLAAYDL 974

Query: 915  SMITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEG 974
                               MIQ  + LIE AD V EKIV CQKA MEFHE LH++G KEG
Sbjct: 975  -------------------MIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEG 1015

Query: 975  LKERKLQKAVESFTWNITILKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLN 1034
            LK RKL KA+ESF WNIT+LK         GQ DLLK AKNE +EN+KQI  A +SCGL+
Sbjct: 1016 LKGRKLNKAIESFAWNITVLK---------GQGDLLKNAKNEAVENIKQIQLACLSCGLS 1066

Query: 1035 KPGTENADVQKPRRSLEVIPEKANDE 1060
            K G  +A   K +RSLE I EK + E
Sbjct: 1067 K-GPGSAAEAKGKRSLEAIEEKESSE 1091



>gi|10435513|dbj|BAB14606.1|   unnamed protein product [Homo sapiens]
          Length = 677

 Score = 1327 bits (3435), Expect = 0.0
 Identities = 635/679 (93%), Positives = 636/679 (93%), Gaps = 19/679 (2%)

Query: 318 MSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRS 377
           MSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRS
Sbjct: 1   MSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRS 60

Query: 378 VELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXX 437
           VELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI    
Sbjct: 61  VELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQK 120

Query: 438 XXXXXXXXLLGDKLYTTSPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEG 497
                   LLGDKLYTTSPNVEESYLPSPDV            SSNCSGVEGDVTDEDEG
Sbjct: 121 VMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEG 180

Query: 498 AEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFN 557
           AEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFN
Sbjct: 181 AEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFN 240

Query: 558 EVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGL 617
           EVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGL
Sbjct: 241 EVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGL 300

Query: 618 MMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKP 677
           MMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKP
Sbjct: 301 MMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKP 360

Query: 678 KGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRF 737
           KGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRF
Sbjct: 361 KGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRF 420

Query: 738 VVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKP 797
           VVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKP
Sbjct: 421 VVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKP 480

Query: 798 HKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCG 857
           HKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCG
Sbjct: 481 HKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCG 540

Query: 858 LSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSMI 917
           LSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM   
Sbjct: 541 LSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDM--- 597

Query: 918 TPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKE 977
                           MIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKE
Sbjct: 598 ----------------MIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKE 641

Query: 978 RKLQKAVESFTWNITILKV 996
           RKLQKAVESFTWNITILK+
Sbjct: 642 RKLQKAVESFTWNITILKI 660



>gi|780122|dbj|BAA07688.1|   Phospholipase C [Homo sapiens]
          Length = 997

 Score = 1323 bits (3423), Expect = 0.0
 Identities = 649/1027 (63%), Positives = 788/1027 (76%), Gaps = 36/1027 (3%)

Query: 35   MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 94
            MP+EKKISSA+DCI+ M  G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 1    MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60

Query: 95   DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 154
            DI +IKE+R GKNT+ F +NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 61   DISAIKEIRLGKNTETFTNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120

Query: 155  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 214
            RYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +    +V+ I+ LNP LK +
Sbjct: 121  RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180

Query: 215  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 274
            KI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD  DLM+F
Sbjct: 181  KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240

Query: 275  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 334
            LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 241  LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300

Query: 335  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 394
            DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++  
Sbjct: 301  DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360

Query: 395  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTT 454
             + MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+            + G+KLYT 
Sbjct: 361  RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420

Query: 455  SPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 513
            +P   ESYLPSP+              S+   +EG+VTDEDE A+MS+RM  + N EQ  
Sbjct: 421  APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAQMSRRMSVDYNGEQ-- 478

Query: 514  NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 573
                K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E  AS+ ANE P DFV
Sbjct: 479  ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534

Query: 574  NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 633
            NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 535  NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594

Query: 634  YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 693
            YVLRP+IMR+EVS+FSANTK  +PGVSP  LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 595  YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654

Query: 694  EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 753
            EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 655  EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714

Query: 754  TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 813
            TIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GGGK  KR LSVR GKK REY
Sbjct: 715  TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774

Query: 814  ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 873
              LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KELCGL  +A+L QC+L +S 
Sbjct: 775  TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834

Query: 874  RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQK 933
            R +  DNTP V L + + +P +E  G +P+V KK++T YD+                   
Sbjct: 835  RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDL------------------- 875

Query: 934  MIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITI 993
            MIQ  + LIE AD V EKIV CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+
Sbjct: 876  MIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITV 935

Query: 994  LKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVI 1053
            LK         GQ DLLK AKNE +EN+KQI  A +SCGL+K  + +A+  K +RSLE I
Sbjct: 936  LK---------GQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEA-KSKRSLEAI 985

Query: 1054 PEKANDE 1060
             EK + E
Sbjct: 986  EEKESSE 992



>gi|2135919|pir||I54390   phosphoinositide-specific phospholipase C (EC 3.1.4.-) epsilon -
            human
          Length = 997

 Score = 1323 bits (3423), Expect = 0.0
 Identities = 649/1027 (63%), Positives = 788/1027 (76%), Gaps = 36/1027 (3%)

Query: 35   MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 94
            MP+EKKISSA+DCI+ M  G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 1    MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60

Query: 95   DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 154
            DI +IKE+R GKNT+ F +NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 61   DISAIKEIRLGKNTETFTNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120

Query: 155  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 214
            RYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +    +V+ I+ LNP LK +
Sbjct: 121  RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180

Query: 215  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 274
            KI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD  DLM+F
Sbjct: 181  KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240

Query: 275  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 334
            LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 241  LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300

Query: 335  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 394
            DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++  
Sbjct: 301  DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360

Query: 395  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTT 454
             + MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+            + G+KLYT 
Sbjct: 361  RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420

Query: 455  SPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 513
            +P   ESYLPSP+              S+   +EG+VTDEDE A+MS+RM  + N EQ  
Sbjct: 421  APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAQMSRRMSVDYNGEQ-- 478

Query: 514  NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 573
                K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E  AS+ ANE P DFV
Sbjct: 479  ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534

Query: 574  NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 633
            NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 535  NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594

Query: 634  YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 693
            YVLRP+IMR+EVS+FSANTK  +PGVSP  LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 595  YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654

Query: 694  EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 753
            EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 655  EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714

Query: 754  TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 813
            TIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GGGK  KR LSVR GKK REY
Sbjct: 715  TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774

Query: 814  ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 873
              LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KELCGL  +A+L QC+L +S 
Sbjct: 775  TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834

Query: 874  RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQK 933
            R +  DNTP V L + + +P +E  G +P+V KK++T YD+                   
Sbjct: 835  RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDL------------------- 875

Query: 934  MIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITI 993
            MIQ  + LIE AD V EKIV CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+
Sbjct: 876  MIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITV 935

Query: 994  LKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVI 1053
            LK         GQ DLLK AKNE +EN+KQI  A +SCGL+K  + +A+  K +RSLE I
Sbjct: 936  LK---------GQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEA-KSKRSLEAI 985

Query: 1054 PEKANDE 1060
             EK + E
Sbjct: 986  EEKESSE 992



>gi|5453912|ref|NP_006217.1|   phospholipase C-like 1; phospholipase C, epsilon [Homo sapiens]
          Length = 997

 Score = 1323 bits (3423), Expect = 0.0
 Identities = 649/1027 (63%), Positives = 788/1027 (76%), Gaps = 36/1027 (3%)

Query: 35   MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 94
            MP+EKKISSA+DCI+ M  G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 1    MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60

Query: 95   DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 154
            DI +IKE+R GKNT+ F +NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 61   DISAIKEIRLGKNTETFTNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120

Query: 155  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 214
            RYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +    +V+ I+ LNP LK +
Sbjct: 121  RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180

Query: 215  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 274
            KI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD  DLM+F
Sbjct: 181  KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240

Query: 275  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 334
            LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 241  LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300

Query: 335  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 394
            DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++  
Sbjct: 301  DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360

Query: 395  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTT 454
             + MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+            + G+KLYT 
Sbjct: 361  RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420

Query: 455  SPNVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 513
            +P   ESYLPSP+              S+   +EG+VTDEDE A+MS+RM  + N EQ  
Sbjct: 421  APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAQMSRRMSVDYNGEQ-- 478

Query: 514  NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 573
                K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E  AS+ ANE P DFV
Sbjct: 479  ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534

Query: 574  NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 633
            NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 535  NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594

Query: 634  YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 693
            YVLRP+IMR+EVS+FSANTK  +PGVSP  LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 595  YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654

Query: 694  EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 753
            EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 655  EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714

Query: 754  TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 813
            TIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GGGK  KR LSVR GKK REY
Sbjct: 715  TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774

Query: 814  ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 873
              LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KELCGL  +A+L QC+L +S 
Sbjct: 775  TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834

Query: 874  RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQK 933
            R +  DNTP V L + + +P +E  G +P+V KK++T YD+                   
Sbjct: 835  RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDL------------------- 875

Query: 934  MIQSLKALIENADAVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITI 993
            MIQ  + LIE AD V EKIV CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+
Sbjct: 876  MIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITV 935

Query: 994  LKVSIELFLMLGQADLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVI 1053
            LK         GQ DLLK AKNE +EN+KQI  A +SCGL+K  + +A+  K +RSLE I
Sbjct: 936  LK---------GQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEA-KSKRSLEAI 985

Query: 1054 PEKANDE 1060
             EK + E
Sbjct: 986  EEKESSE 992



>gi|25144969|ref|NP_741068.1|   Phospholipase C (121.1 kD) [Caenorhabditis elegans]
          Length = 1075

 Score =  737 bits (1903), Expect = 0.0
 Identities = 399/1008 (39%), Positives = 588/1008 (58%), Gaps = 75/1008 (7%)

Query: 27   KKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSK 86
            +KTVSFSS  ++ KIS+ SDC N M  GS+  K+R  +R + R+F LDAD+  +RW P+ 
Sbjct: 58   RKTVSFSSKNSDAKISNVSDCWNYMQTGSDFVKLRGTNRQFRRFFSLDADLSYIRWTPTN 117

Query: 87   KDSEKAKIDIKSIKEVRTGKNTDIFRSNG-ISDQISEDCAFSVIYGENYESLDLVANSAD 145
            K   KA+I I  I+E+R GKNT++ RS+  +   + E+C FS+IYG+NYE+LDL+A+S D
Sbjct: 118  KKPHKARIAIDEIREIRLGKNTELLRSSDEVFTDLQEECLFSIIYGDNYETLDLIASSGD 177

Query: 146  VANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIR 205
             ANIWVTGL  L S  K+      S    +R  W+  +F E D    GH+    A + I 
Sbjct: 178  DANIWVTGLMALTS-NKYECKPSSSQFATLRERWIESVFDEFDTKKNGHLDEQTAFKAIL 236

Query: 206  NLNPGLKTSKIELKFKELH-KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKE 264
            ++N  +   ++  K KE+   +++    ++ K  F++++ E+ TRPE+YFL+V++ +NK+
Sbjct: 237  HINSRISHHRLTNKLKEVTIGAEESERGKIEKSHFVDLYKEIGTRPEVYFLMVRY-ANKD 295

Query: 265  FLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYI 324
            +L  +DL +FLE EQG+  +  +    +I +YEP  E +E   +++DGFT++L SPDC +
Sbjct: 296  YLSCQDLRLFLETEQGMVGVTTDNCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGV 355

Query: 325  FDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWD 384
            FDP H+ V  DMKQP S YFI+SS  +YL+EDQ  GPS   G+  ALK  CR +E D+WD
Sbjct: 356  FDPNHRVVTMDMKQPFSRYFISSSRKSYLVEDQL-GPSSSDGFSSALKRNCRFLEFDIWD 414

Query: 385  ----GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXX 440
                  D EP++  G T TS+I   S + II ++AF  S YPL+L +  HCS        
Sbjct: 415  PNEADGDTEPMVQNGQTATSKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAA 474

Query: 441  XXXXXLLGDKLYTTSPNV----EESYLPSP-DVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                  LG +LY    +     +E   P+P D             + +     G+V++ED
Sbjct: 475  MLIVTHLGTRLYLPKNDPTNWDDEKNCPTPWDFQNRILIVGKKLDNPDTD--SGEVSEED 532

Query: 496  EGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQ-----FKEFQVSFQVQKY 550
            +    + R              KR QLCKELS+LV +  +V+           S  +   
Sbjct: 533  DSLASTTRRKS-----------KRIQLCKELSDLVPVFFNVKTLNDLLSTAPGSTTMSSR 581

Query: 551  WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 610
              + S  E    +  +    +F    + +  RVFP+P R+DSSN+NPQ+FW  G Q+V +
Sbjct: 582  KNLASVTESTCLRLMHTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNNGVQMVCL 641

Query: 611  NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 670
            N+QTPGLMMDL  G F  NG CGYVL+P +M++++   S    D VP  SPQ+LH++I+S
Sbjct: 642  NYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVPS----DRVP-TSPQILHLRILS 696

Query: 671  GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLP 730
            GQ  P+P+GS AKGD  DP+V VE+ G+P DCAE+RT+TV  +   P FDESF+FQ+++P
Sbjct: 697  GQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSINPSFDESFQFQVSVP 756

Query: 731  ELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITN 790
            ELA+VRF+VLDDDYIGD+FIGQYTIPFECLQ GYRH+ L +  G+ L HA+LFVHVAITN
Sbjct: 757  ELALVRFLVLDDDYIGDDFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHATLFVHVAITN 816

Query: 791  RRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVV 850
            RRGGGK  KRG+SV++ K SR  + ++ + IK+VD+ FK A  P+ ++T +R  ++NA++
Sbjct: 817  RRGGGKAKKRGMSVKR-KNSRISSGMKLVGIKSVDDQFKVAVVPLAESTAIRNRLENAMI 875

Query: 851  SFKELCGLSSVANLMQCMLAVSPRFLG-----------------PDNTPLVVLNLSEQ-Y 892
             ++E CGL     + Q +  +  R +                     TPL +++  E  Y
Sbjct: 876  DWQEECGLGPAGTIRQGIRLIHSRMITLAVNSSPPPSPTTSSAESSVTPLFIIDSDEHGY 935

Query: 893  PTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKI 952
            P +   G +P+ L++            F+K++         +I      +  +D +  KI
Sbjct: 936  PAIVTMGTLPDQLQR-----------SFNKLK--------NLIAHCVTTLSQSDQLLSKI 976

Query: 953  VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKVSIEL 1000
                +   E HE L  +  + GLK +K  +A E+FTWN+ +LK  + L
Sbjct: 977  EDSIRRISECHEELSKLCAEAGLKGQKATRAAENFTWNLRLLKAQLNL 1024



>gi|25112181|gb|AAN72422.1|   Hypothetical protein K10F12.3a [Caenorhabditis elegans]
          Length = 1075

 Score =  737 bits (1903), Expect = 0.0
 Identities = 399/1008 (39%), Positives = 588/1008 (58%), Gaps = 75/1008 (7%)

Query: 27   KKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSK 86
            +KTVSFSS  ++ KIS+ SDC N M  GS+  K+R  +R + R+F LDAD+  +RW P+ 
Sbjct: 58   RKTVSFSSKNSDAKISNVSDCWNYMQTGSDFVKLRGTNRQFRRFFSLDADLSYIRWTPTN 117

Query: 87   KDSEKAKIDIKSIKEVRTGKNTDIFRSNG-ISDQISEDCAFSVIYGENYESLDLVANSAD 145
            K   KA+I I  I+E+R GKNT++ RS+  +   + E+C FS+IYG+NYE+LDL+A+S D
Sbjct: 118  KKPHKARIAIDEIREIRLGKNTELLRSSDEVFTDLQEECLFSIIYGDNYETLDLIASSGD 177

Query: 146  VANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIR 205
             ANIWVTGL  L S  K+      S    +R  W+  +F E D    GH+    A + I 
Sbjct: 178  DANIWVTGLMALTS-NKYECKPSSSQFATLRERWIESVFDEFDTKKNGHLDEQTAFKAIL 236

Query: 206  NLNPGLKTSKIELKFKELH-KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKE 264
            ++N  +   ++  K KE+   +++    ++ K  F++++ E+ TRPE+YFL+V++ +NK+
Sbjct: 237  HINSRISHHRLTNKLKEVTIGAEESERGKIEKSHFVDLYKEIGTRPEVYFLMVRY-ANKD 295

Query: 265  FLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYI 324
            +L  +DL +FLE EQG+  +  +    +I +YEP  E +E   +++DGFT++L SPDC +
Sbjct: 296  YLSCQDLRLFLETEQGMVGVTTDNCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGV 355

Query: 325  FDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWD 384
            FDP H+ V  DMKQP S YFI+SS  +YL+EDQ  GPS   G+  ALK  CR +E D+WD
Sbjct: 356  FDPNHRVVTMDMKQPFSRYFISSSRKSYLVEDQL-GPSSSDGFSSALKRNCRFLEFDIWD 414

Query: 385  ----GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXX 440
                  D EP++  G T TS+I   S + II ++AF  S YPL+L +  HCS        
Sbjct: 415  PNEADGDTEPMVQNGQTATSKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAA 474

Query: 441  XXXXXLLGDKLYTTSPNV----EESYLPSP-DVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                  LG +LY    +     +E   P+P D             + +     G+V++ED
Sbjct: 475  MLIVTHLGTRLYLPKNDPTNWDDEKNCPTPWDFQNRILIVGKKLDNPDTD--SGEVSEED 532

Query: 496  EGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQ-----FKEFQVSFQVQKY 550
            +    + R              KR QLCKELS+LV +  +V+           S  +   
Sbjct: 533  DSLASTTRRKS-----------KRIQLCKELSDLVPVFFNVKTLNDLLSTAPGSTTMSSR 581

Query: 551  WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 610
              + S  E    +  +    +F    + +  RVFP+P R+DSSN+NPQ+FW  G Q+V +
Sbjct: 582  KNLASVTESTCLRLMHTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNNGVQMVCL 641

Query: 611  NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 670
            N+QTPGLMMDL  G F  NG CGYVL+P +M++++   S    D VP  SPQ+LH++I+S
Sbjct: 642  NYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVPS----DRVP-TSPQILHLRILS 696

Query: 671  GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLP 730
            GQ  P+P+GS AKGD  DP+V VE+ G+P DCAE+RT+TV  +   P FDESF+FQ+++P
Sbjct: 697  GQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSINPSFDESFQFQVSVP 756

Query: 731  ELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITN 790
            ELA+VRF+VLDDDYIGD+FIGQYTIPFECLQ GYRH+ L +  G+ L HA+LFVHVAITN
Sbjct: 757  ELALVRFLVLDDDYIGDDFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHATLFVHVAITN 816

Query: 791  RRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVV 850
            RRGGGK  KRG+SV++ K SR  + ++ + IK+VD+ FK A  P+ ++T +R  ++NA++
Sbjct: 817  RRGGGKAKKRGMSVKR-KNSRISSGMKLVGIKSVDDQFKVAVVPLAESTAIRNRLENAMI 875

Query: 851  SFKELCGLSSVANLMQCMLAVSPRFLG-----------------PDNTPLVVLNLSEQ-Y 892
             ++E CGL     + Q +  +  R +                     TPL +++  E  Y
Sbjct: 876  DWQEECGLGPAGTIRQGIRLIHSRMITLAVNSSPPPSPTTSSAESSVTPLFIIDSDEHGY 935

Query: 893  PTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKI 952
            P +   G +P+ L++            F+K++         +I      +  +D +  KI
Sbjct: 936  PAIVTMGTLPDQLQR-----------SFNKLK--------NLIAHCVTTLSQSDQLLSKI 976

Query: 953  VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKVSIEL 1000
                +   E HE L  +  + GLK +K  +A E+FTWN+ +LK  + L
Sbjct: 977  EDSIRRISECHEELSKLCAEAGLKGQKATRAAENFTWNLRLLKAQLNL 1024



>gi|25144971|ref|NP_741067.1|   Phospholipase C-L2 (120.0 kD) [Caenorhabditis elegans]
          Length = 1068

 Score =  735 bits (1898), Expect = 0.0
 Identities = 399/1008 (39%), Positives = 588/1008 (58%), Gaps = 75/1008 (7%)

Query: 27   KKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSK 86
            +KTVSFSS  ++ KIS+ SDC N M  GS+  K+R  +R + R+F LDAD+  +RW P+ 
Sbjct: 51   RKTVSFSSKNSDAKISNVSDCWNYMQTGSDFVKLRGTNRQFRRFFSLDADLSYIRWTPTN 110

Query: 87   KDSEKAKIDIKSIKEVRTGKNTDIFRSNG-ISDQISEDCAFSVIYGENYESLDLVANSAD 145
            K   KA+I I  I+E+R GKNT++ RS+  +   + E+C FS+IYG+NYE+LDL+A+S D
Sbjct: 111  KKPHKARIAIDEIREIRLGKNTELLRSSDEVFTDLQEECLFSIIYGDNYETLDLIASSGD 170

Query: 146  VANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIR 205
             ANIWVTGL  L S  K+      S    +R  W+  +F E D    GH+    A + I 
Sbjct: 171  DANIWVTGLMALTS-NKYECKPSSSQFATLRERWIESVFDEFDTKKNGHLDEQTAFKAIL 229

Query: 206  NLNPGLKTSKIELKFKELH-KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKE 264
            ++N  +   ++  K KE+   +++    ++ K  F++++ E+ TRPE+YFL+V++ +NK+
Sbjct: 230  HINSRISHHRLTNKLKEVTIGAEESERGKIEKSHFVDLYKEIGTRPEVYFLMVRY-ANKD 288

Query: 265  FLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYI 324
            +L  +DL +FLE EQG+  +  +    +I +YEP  E +E   +++DGFT++L SPDC +
Sbjct: 289  YLSCQDLRLFLETEQGMVGVTTDNCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGV 348

Query: 325  FDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWD 384
            FDP H+ V  DMKQP S YFI+SS  +YL+EDQ  GPS   G+  ALK  CR +E D+WD
Sbjct: 349  FDPNHRVVTMDMKQPFSRYFISSSRKSYLVEDQL-GPSSSDGFSSALKRNCRFLEFDIWD 407

Query: 385  ----GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXX 440
                  D EP++  G T TS+I   S + II ++AF  S YPL+L +  HCS        
Sbjct: 408  PNEADGDTEPMVQNGQTATSKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAA 467

Query: 441  XXXXXLLGDKLYTTSPNV----EESYLPSP-DVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                  LG +LY    +     +E   P+P D             + +     G+V++ED
Sbjct: 468  MLIVTHLGTRLYLPKNDPTNWDDEKNCPTPWDFQNRILIVGKKLDNPDTD--SGEVSEED 525

Query: 496  EGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQ-----FKEFQVSFQVQKY 550
            +    + R              KR QLCKELS+LV +  +V+           S  +   
Sbjct: 526  DSLASTTRRKS-----------KRIQLCKELSDLVPVFFNVKTLNDLLSTAPGSTTMSSR 574

Query: 551  WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 610
              + S  E    +  +    +F    + +  RVFP+P R+DSSN+NPQ+FW  G Q+V +
Sbjct: 575  KNLASVTESTCLRLMHTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNNGVQMVCL 634

Query: 611  NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 670
            N+QTPGLMMDL  G F  NG CGYVL+P +M++++   S    D VP  SPQ+LH++I+S
Sbjct: 635  NYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVPS----DRVP-TSPQILHLRILS 689

Query: 671  GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLP 730
            GQ  P+P+GS AKGD  DP+V VE+ G+P DCAE+RT+TV  +   P FDESF+FQ+++P
Sbjct: 690  GQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSINPSFDESFQFQVSVP 749

Query: 731  ELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITN 790
            ELA+VRF+VLDDDYIGD+FIGQYTIPFECLQ GYRH+ L +  G+ L HA+LFVHVAITN
Sbjct: 750  ELALVRFLVLDDDYIGDDFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHATLFVHVAITN 809

Query: 791  RRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVV 850
            RRGGGK  KRG+SV++ K SR  + ++ + IK+VD+ FK A  P+ ++T +R  ++NA++
Sbjct: 810  RRGGGKAKKRGMSVKR-KNSRISSGMKLVGIKSVDDQFKVAVVPLAESTAIRNRLENAMI 868

Query: 851  SFKELCGLSSVANLMQCMLAVSPRFLG-----------------PDNTPLVVLNLSEQ-Y 892
             ++E CGL     + Q +  +  R +                     TPL +++  E  Y
Sbjct: 869  DWQEECGLGPAGTIRQGIRLIHSRMITLAVNSSPPPSPTTSSAESSVTPLFIIDSDEHGY 928

Query: 893  PTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKI 952
            P +   G +P+ L++            F+K++         +I      +  +D +  KI
Sbjct: 929  PAIVTMGTLPDQLQR-----------SFNKLK--------NLIAHCVTTLSQSDQLLSKI 969

Query: 953  VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKVSIEL 1000
                +   E HE L  +  + GLK +K  +A E+FTWN+ +LK  + L
Sbjct: 970  EDSIRRISECHEELSKLCAEAGLKGQKATRAAENFTWNLRLLKAQLNL 1017



>gi|25112182|gb|AAN72423.1|   Hypothetical protein K10F12.3b [Caenorhabditis elegans]
          Length = 1068

 Score =  735 bits (1898), Expect = 0.0
 Identities = 399/1008 (39%), Positives = 588/1008 (58%), Gaps = 75/1008 (7%)

Query: 27   KKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSK 86
            +KTVSFSS  ++ KIS+ SDC N M  GS+  K+R  +R + R+F LDAD+  +RW P+ 
Sbjct: 51   RKTVSFSSKNSDAKISNVSDCWNYMQTGSDFVKLRGTNRQFRRFFSLDADLSYIRWTPTN 110

Query: 87   KDSEKAKIDIKSIKEVRTGKNTDIFRSNG-ISDQISEDCAFSVIYGENYESLDLVANSAD 145
            K   KA+I I  I+E+R GKNT++ RS+  +   + E+C FS+IYG+NYE+LDL+A+S D
Sbjct: 111  KKPHKARIAIDEIREIRLGKNTELLRSSDEVFTDLQEECLFSIIYGDNYETLDLIASSGD 170

Query: 146  VANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIR 205
             ANIWVTGL  L S  K+      S    +R  W+  +F E D    GH+    A + I 
Sbjct: 171  DANIWVTGLMALTS-NKYECKPSSSQFATLRERWIESVFDEFDTKKNGHLDEQTAFKAIL 229

Query: 206  NLNPGLKTSKIELKFKELH-KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKE 264
            ++N  +   ++  K KE+   +++    ++ K  F++++ E+ TRPE+YFL+V++ +NK+
Sbjct: 230  HINSRISHHRLTNKLKEVTIGAEESERGKIEKSHFVDLYKEIGTRPEVYFLMVRY-ANKD 288

Query: 265  FLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYI 324
            +L  +DL +FLE EQG+  +  +    +I +YEP  E +E   +++DGFT++L SPDC +
Sbjct: 289  YLSCQDLRLFLETEQGMVGVTTDNCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGV 348

Query: 325  FDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWD 384
            FDP H+ V  DMKQP S YFI+SS  +YL+EDQ  GPS   G+  ALK  CR +E D+WD
Sbjct: 349  FDPNHRVVTMDMKQPFSRYFISSSRKSYLVEDQL-GPSSSDGFSSALKRNCRFLEFDIWD 407

Query: 385  ----GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXX 440
                  D EP++  G T TS+I   S + II ++AF  S YPL+L +  HCS        
Sbjct: 408  PNEADGDTEPMVQNGQTATSKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAA 467

Query: 441  XXXXXLLGDKLYTTSPNV----EESYLPSP-DVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                  LG +LY    +     +E   P+P D             + +     G+V++ED
Sbjct: 468  MLIVTHLGTRLYLPKNDPTNWDDEKNCPTPWDFQNRILIVGKKLDNPDTD--SGEVSEED 525

Query: 496  EGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQ-----FKEFQVSFQVQKY 550
            +    + R              KR QLCKELS+LV +  +V+           S  +   
Sbjct: 526  DSLASTTRRKS-----------KRIQLCKELSDLVPVFFNVKTLNDLLSTAPGSTTMSSR 574

Query: 551  WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 610
              + S  E    +  +    +F    + +  RVFP+P R+DSSN+NPQ+FW  G Q+V +
Sbjct: 575  KNLASVTESTCLRLMHTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNNGVQMVCL 634

Query: 611  NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 670
            N+QTPGLMMDL  G F  NG CGYVL+P +M++++   S    D VP  SPQ+LH++I+S
Sbjct: 635  NYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVPS----DRVP-TSPQILHLRILS 689

Query: 671  GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLP 730
            GQ  P+P+GS AKGD  DP+V VE+ G+P DCAE+RT+TV  +   P FDESF+FQ+++P
Sbjct: 690  GQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSINPSFDESFQFQVSVP 749

Query: 731  ELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITN 790
            ELA+VRF+VLDDDYIGD+FIGQYTIPFECLQ GYRH+ L +  G+ L HA+LFVHVAITN
Sbjct: 750  ELALVRFLVLDDDYIGDDFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHATLFVHVAITN 809

Query: 791  RRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVV 850
            RRGGGK  KRG+SV++ K SR  + ++ + IK+VD+ FK A  P+ ++T +R  ++NA++
Sbjct: 810  RRGGGKAKKRGMSVKR-KNSRISSGMKLVGIKSVDDQFKVAVVPLAESTAIRNRLENAMI 868

Query: 851  SFKELCGLSSVANLMQCMLAVSPRFLG-----------------PDNTPLVVLNLSEQ-Y 892
             ++E CGL     + Q +  +  R +                     TPL +++  E  Y
Sbjct: 869  DWQEECGLGPAGTIRQGIRLIHSRMITLAVNSSPPPSPTTSSAESSVTPLFIIDSDEHGY 928

Query: 893  PTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQKMIQSLKALIENADAVYEKI 952
            P +   G +P+ L++            F+K++         +I      +  +D +  KI
Sbjct: 929  PAIVTMGTLPDQLQR-----------SFNKLK--------NLIAHCVTTLSQSDQLLSKI 969

Query: 953  VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKVSIEL 1000
                +   E HE L  +  + GLK +K  +A E+FTWN+ +LK  + L
Sbjct: 970  EDSIRRISECHEELSKLCAEAGLKGQKATRAAENFTWNLRLLKAQLNL 1017



>gi|7505734|pir||T32374   hypothetical protein K10F12.3 - Caenorhabditis elegans
          Length = 895

 Score =  704 bits (1818), Expect = 0.0
 Identities = 367/866 (42%), Positives = 532/866 (61%), Gaps = 38/866 (4%)

Query: 27  KKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSK 86
           +KTVSFSS  ++ KIS+ SDC N M  GS+  K+R  +R + R+F LDAD+  +RW P+ 
Sbjct: 29  RKTVSFSSKNSDAKISNVSDCWNYMQTGSDFVKLRGTNRQFRRFFSLDADLSYIRWTPTN 88

Query: 87  KDSEKAKIDIKSIKEVRTGKNTDIFRSNG-ISDQISEDCAFSVIYGENYESLDLVANSAD 145
           K   KA+I I  I+E+R GKNT++ RS+  +   + E+C FS+IYG+NYE+LDL+A+S D
Sbjct: 89  KKPHKARIAIDEIREIRLGKNTELLRSSDEVFTDLQEECLFSIIYGDNYETLDLIASSGD 148

Query: 146 VANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIR 205
            ANIWVTGL  L S  K+      S    +R  W+  +F E D    GH+    A + I 
Sbjct: 149 DANIWVTGLMALTS-NKYECKPSSSQFATLRERWIESVFDEFDTKKNGHLDEQTAFKAIL 207

Query: 206 NLNPGLKTSKIELKFKELH-KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKE 264
           ++N  +   ++  K KE+   +++    ++ K  F++++ E+ TRPE+YFL+V++ +NK+
Sbjct: 208 HINSRISHHRLTNKLKEVTIGAEESERGKIEKSHFVDLYKEIGTRPEVYFLMVRY-ANKD 266

Query: 265 FLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYI 324
           +L  +DL +FLE EQG+  +  +    +I +YEP  E +E   +++DGFT++L SPDC +
Sbjct: 267 YLSCQDLRLFLETEQGMVGVTTDNCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGV 326

Query: 325 FDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWD 384
           FDP H+ V  DMKQP S YFI+SS  +YL+EDQ  GPS   G+  ALK  CR +E D+WD
Sbjct: 327 FDPNHRVVTMDMKQPFSRYFISSSRKSYLVEDQL-GPSSSDGFSSALKRNCRFLEFDIWD 385

Query: 385 ----GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXX 440
                 D EP++  G T TS+I   S + II ++AF  S YPL+L +  HCS        
Sbjct: 386 PNEADGDTEPMVQNGQTATSKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAA 445

Query: 441 XXXXXLLGDKLYTTSPNV----EESYLPSP-DVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                 LG +LY    +     +E   P+P D             + +     G+V++ED
Sbjct: 446 MLIVTHLGTRLYLPKNDPTNWDDEKNCPTPWDFQNRILIVGKKLDNPDTD--SGEVSEED 503

Query: 496 EGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQ-----FKEFQVSFQVQKY 550
           +    + R              KR QLCKELS+LV +  +V+           S  +   
Sbjct: 504 DSLASTTRRKS-----------KRIQLCKELSDLVPVFFNVKTLNDLLSTAPGSTTMSSR 552

Query: 551 WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 610
             + S  E    +  +    +F    + +  RVFP+P R+DSSN+NPQ+FW  G Q+V +
Sbjct: 553 KNLASVTESTCLRLMHTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNNGVQMVCL 612

Query: 611 NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 670
           N+QTPGLMMDL  G F  NG CGYVL+P +M++++   S    D VP  SPQ+LH++I+S
Sbjct: 613 NYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVPS----DRVP-TSPQILHLRILS 667

Query: 671 GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLP 730
           GQ  P+P+GS AKGD  DP+V VE+ G+P DCAE+RT+TV  +   P FDESF+FQ+++P
Sbjct: 668 GQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSINPSFDESFQFQVSVP 727

Query: 731 ELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITN 790
           ELA+VRF+VLDDDYIGD+FIGQYTIPFECLQ GYRH+ L +  G+ L HA+LFVHVAITN
Sbjct: 728 ELALVRFLVLDDDYIGDDFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHATLFVHVAITN 787

Query: 791 RRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVV 850
           RRGGGK  KRG+SV++ K SR  + ++ + IK+VD+ FK A  P+ ++T +R  ++NA++
Sbjct: 788 RRGGGKAKKRGMSVKR-KNSRISSGMKLVGIKSVDDQFKVAVVPLAESTAIRNRLENAMI 846

Query: 851 SFKELCGLSSVANLMQCMLAVSPRFL 876
            ++E CGL     + Q +  +  R +
Sbjct: 847 DWQEECGLGPAGTIRQGIRLIHSRMI 872



>gi|17554140|ref|NP_497191.1|   phospholipase C [Caenorhabditis elegans]
          Length = 895

 Score =  704 bits (1818), Expect = 0.0
 Identities = 367/866 (42%), Positives = 532/866 (61%), Gaps = 38/866 (4%)

Query: 27  KKTVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSK 86
           +KTVSFSS  ++ KIS+ SDC N M  GS+  K+R  +R + R+F LDAD+  +RW P+ 
Sbjct: 29  RKTVSFSSKNSDAKISNVSDCWNYMQTGSDFVKLRGTNRQFRRFFSLDADLSYIRWTPTN 88

Query: 87  KDSEKAKIDIKSIKEVRTGKNTDIFRSNG-ISDQISEDCAFSVIYGENYESLDLVANSAD 145
           K   KA+I I  I+E+R GKNT++ RS+  +   + E+C FS+IYG+NYE+LDL+A+S D
Sbjct: 89  KKPHKARIAIDEIREIRLGKNTELLRSSDEVFTDLQEECLFSIIYGDNYETLDLIASSGD 148

Query: 146 VANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIR 205
            ANIWVTGL  L S  K+      S    +R  W+  +F E D    GH+    A + I 
Sbjct: 149 DANIWVTGLMALTS-NKYECKPSSSQFATLRERWIESVFDEFDTKKNGHLDEQTAFKAIL 207

Query: 206 NLNPGLKTSKIELKFKELH-KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKE 264
           ++N  +   ++  K KE+   +++    ++ K  F++++ E+ TRPE+YFL+V++ +NK+
Sbjct: 208 HINSRISHHRLTNKLKEVTIGAEESERGKIEKSHFVDLYKEIGTRPEVYFLMVRY-ANKD 266

Query: 265 FLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYI 324
           +L  +DL +FLE EQG+  +  +    +I +YEP  E +E   +++DGFT++L SPDC +
Sbjct: 267 YLSCQDLRLFLETEQGMVGVTTDNCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGV 326

Query: 325 FDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWD 384
           FDP H+ V  DMKQP S YFI+SS  +YL+EDQ  GPS   G+  ALK  CR +E D+WD
Sbjct: 327 FDPNHRVVTMDMKQPFSRYFISSSRKSYLVEDQL-GPSSSDGFSSALKRNCRFLEFDIWD 385

Query: 385 ----GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXX 440
                 D EP++  G T TS+I   S + II ++AF  S YPL+L +  HCS        
Sbjct: 386 PNEADGDTEPMVQNGQTATSKITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAA 445

Query: 441 XXXXXLLGDKLYTTSPNV----EESYLPSP-DVXXXXXXXXXXXXSSNCSGVEGDVTDED 495
                 LG +LY    +     +E   P+P D             + +     G+V++ED
Sbjct: 446 MLIVTHLGTRLYLPKNDPTNWDDEKNCPTPWDFQNRILIVGKKLDNPDTD--SGEVSEED 503

Query: 496 EGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQ-----FKEFQVSFQVQKY 550
           +    + R              KR QLCKELS+LV +  +V+           S  +   
Sbjct: 504 DSLASTTRRKS-----------KRIQLCKELSDLVPVFFNVKTLNDLLSTAPGSTTMSSR 552

Query: 551 WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 610
             + S  E    +  +    +F    + +  RVFP+P R+DSSN+NPQ+FW  G Q+V +
Sbjct: 553 KNLASVTESTCLRLMHTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNNGVQMVCL 612

Query: 611 NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 670
           N+QTPGLMMDL  G F  NG CGYVL+P +M++++   S    D VP  SPQ+LH++I+S
Sbjct: 613 NYQTPGLMMDLQEGKFSDNGGCGYVLKPQVMKDDMFVPS----DRVP-TSPQILHLRILS 667

Query: 671 GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLP 730
           GQ  P+P+GS AKGD  DP+V VE+ G+P DCAE+RT+TV  +   P FDESF+FQ+++P
Sbjct: 668 GQQLPRPRGSNAKGDSADPFVVVEVFGLPGDCAEERTRTVRNDSINPSFDESFQFQVSVP 727

Query: 731 ELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITN 790
           ELA+VRF+VLDDDYIGD+FIGQYTIPFECLQ GYRH+ L +  G+ L HA+LFVHVAITN
Sbjct: 728 ELALVRFLVLDDDYIGDDFIGQYTIPFECLQPGYRHIYLLNNEGDPLEHATLFVHVAITN 787

Query: 791 RRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVV 850
           RRGGGK  KRG+SV++ K SR  + ++ + IK+VD+ FK A  P+ ++T +R  ++NA++
Sbjct: 788 RRGGGKAKKRGMSVKR-KNSRISSGMKLVGIKSVDDQFKVAVVPLAESTAIRNRLENAMI 846

Query: 851 SFKELCGLSSVANLMQCMLAVSPRFL 876
            ++E CGL     + Q +  +  R +
Sbjct: 847 DWQEECGLGPAGTIRQGIRLIHSRMI 872



>gi|28478991|ref|XP_129785.2|   similar to 130kDa-Ins(1,4,5)P3 binding protein [Rattus norvegicus]
            [Mus musculus]
          Length = 449

 Score =  641 bits (1654), Expect = 0.0
 Identities = 306/473 (64%), Positives = 359/473 (75%), Gaps = 29/473 (6%)

Query: 588  MRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSF 647
            MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CGYVLRP+IMR+EVS+
Sbjct: 1    MRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSY 60

Query: 648  FSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRT 707
            FSANTK  VPGVSP +LHIKIISGQNFPKPKG+ AKGDV+DPYV VEIHGIPADC EQRT
Sbjct: 61   FSANTKGIVPGVSPLVLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCCEQRT 120

Query: 708  KTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHV 767
            KTV QN D PIFDE+FEFQ+NLPEL MVRFV+LDDDYIGDEFIGQYTIPFECLQ GYRHV
Sbjct: 121  KTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHV 180

Query: 768  PLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEV 827
            PL+S  G+++ H +LFVH+AITNR GGGKP KR LSVR GKK REY  LR + +KT+D++
Sbjct: 181  PLRSFVGDIMEHVTLFVHIAITNRSGGGKPQKRSLSVRMGKKVREYTMLRNIGLKTIDDI 240

Query: 828  FKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLN 887
            FK A  P+R+A D+RENMQNA+VS KELCGL  +A+L QC+L +S R +  D+TP V L 
Sbjct: 241  FKIAVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDSTPSVSLV 300

Query: 888  LSEQYPTMELQGIVPEVLKKIVTTYDMSMITPFHKVRFKVQNEKQKMIQSLKALIENADA 947
            + + +P +E  G +P+V K+++  YD+                   MIQ  + LIE AD 
Sbjct: 301  MKDCFPYLEPLGAIPDVQKRMLAAYDL-------------------MIQESRVLIEMADT 341

Query: 948  VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKVSIELFLMLGQA 1007
            V EKIV CQKA MEFHE LH++G KEGLK RKL KA+ESF WNIT+LK         GQ 
Sbjct: 342  VQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAWNITVLK---------GQG 392

Query: 1008 DLLKYAKNETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 1060
            DLLK AKNE +EN+KQI  A +SCGL+K G       K +RSLE I EK + E
Sbjct: 393  DLLKNAKNEAVENIKQIQLACLSCGLSK-GPGGGSEAKGKRSLEAIEEKESSE 444



>gi|13623501|gb|AAH06355.1|AAH06355   Unknown (protein for MGC:12837) [Homo sapiens]
          Length = 762

 Score =  477 bits (1228), Expect = e-133
 Identities = 278/751 (37%), Positives = 414/751 (55%), Gaps = 28/751 (3%)

Query: 51  MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 110
           M EG  ++KVRS S    RYF L  D  ++      + S K    I  ++ +R G ++++
Sbjct: 18  MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77

Query: 111 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 170
            RS  +++++  +  F++++     +LDL+ANS + A IW+ GL+ L+       D++ S
Sbjct: 78  LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128

Query: 171 SQDNMR-TSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDK 229
                R   W+S  F   D +  G ++     + +  +N  +     E  F     +   
Sbjct: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185

Query: 230 AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEIS 289
               +  EEF++ +  L  R E+  L   FS++ + L   + + FL+ EQ       E++
Sbjct: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245

Query: 290 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSH 349
           LE+I +YEPS  G+ +  LS+DGF +YL S D  IF+P    + QDM QPL+HYFI SSH
Sbjct: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305

Query: 350 NTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVID 409
           NTYL+ DQ  G S + GYIRALK GCR VE+DVWDGP  EPV+Y GHT+TS+I+F+ V+ 
Sbjct: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365

Query: 410 IINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPN-VEESYLPSPDV 468
            + +YAF  S+YP+IL LE HCS             +LG++L +T+ + V  + LPSP+ 
Sbjct: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEE 425

Query: 469 XXXXXXXXXXXXSSNCSGVEGDVTDEDEGA----------EMSQRMGKENMEQPNNVPVK 518
                       +        +   E E            E      ++N++  +     
Sbjct: 426 LRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKS 485

Query: 519 RFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
           +  LC  LS LV   KSV F+ F  S +   ++E+ SF+E  A +   E   +FV +N  
Sbjct: 486 KPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTW 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+RV+PS +R DSSN NPQ+ W  GCQ+VAMN QT GL MD+  G FRQNG CGYVL+P
Sbjct: 546 QLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
             +R+  S F  + +  +     Q L I++ISGQ  PK   +  +G +VDP V V+I G+
Sbjct: 606 DFLRDIQSSF--HPEKPISPFKAQTLLIQVISGQQLPKVDKT-KEGSIVDPLVKVQIFGV 662

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPF 757
             D A Q T  V  NG  P + ++  F++ +PELAM+RFVV+D D+   ++FIGQYT+P+
Sbjct: 663 RLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPW 722

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
            C+Q GYRH+ L S  G  L  AS+FV++ I
Sbjct: 723 TCMQQGYRHIHLLSKDGISLRPASIFVYICI 753



>gi|14249340|ref|NP_116115.1|   phospholipase C, delta 4; PLC delta4 [Homo sapiens]
          Length = 762

 Score =  477 bits (1228), Expect = e-133
 Identities = 278/751 (37%), Positives = 414/751 (55%), Gaps = 28/751 (3%)

Query: 51  MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 110
           M EG  ++KVRS S    RYF L  D  ++      + S K    I  ++ +R G ++++
Sbjct: 18  MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77

Query: 111 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 170
            RS  +++++  +  F++++     +LDL+ANS + A IW+ GL+ L+       D++ S
Sbjct: 78  LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128

Query: 171 SQDNMR-TSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDK 229
                R   W+S  F   D +  G ++     + +  +N  +     E  F     +   
Sbjct: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185

Query: 230 AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEIS 289
               +  EEF++ +  L  R E+  L   FS++ + L   + + FL+ EQ       E++
Sbjct: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245

Query: 290 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSH 349
           LE+I +YEPS  G+ +  LS+DGF +YL S D  IF+P    + QDM QPL+HYFI SSH
Sbjct: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305

Query: 350 NTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVID 409
           NTYL+ DQ  G S + GYIRALK GCR VE+DVWDGP  EPV+Y GHT+TS+I+F+ V+ 
Sbjct: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365

Query: 410 IINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPN-VEESYLPSPDV 468
            + +YAF  S+YP+IL LE HCS             +LG++L +T+ + V  + LPSP+ 
Sbjct: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEE 425

Query: 469 XXXXXXXXXXXXSSNCSGVEGDVTDEDEGA----------EMSQRMGKENMEQPNNVPVK 518
                       +        +   E E            E      ++N++  +     
Sbjct: 426 LRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKS 485

Query: 519 RFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
           +  LC  LS LV   KSV F+ F  S +   ++E+ SF+E  A +   E   +FV +N  
Sbjct: 486 KPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTW 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+RV+PS +R DSSN NPQ+ W  GCQ+VAMN QT GL MD+  G FRQNG CGYVL+P
Sbjct: 546 QLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
             +R+  S F  + +  +     Q L I++ISGQ  PK   +  +G +VDP V V+I G+
Sbjct: 606 DFLRDIQSSF--HPEKPISPFKAQTLLIQVISGQQLPKVDKT-KEGSIVDPLVKVQIFGV 662

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPF 757
             D A Q T  V  NG  P + ++  F++ +PELAM+RFVV+D D+   ++FIGQYT+P+
Sbjct: 663 RLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPW 722

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
            C+Q GYRH+ L S  G  L  AS+FV++ I
Sbjct: 723 TCMQQGYRHIHLLSKDGISLRPASIFVYICI 753



>gi|20269957|gb|AAM18122.1|AF498759_1   phospholipase C delta 4 [Sus scrofa]
          Length = 772

 Score =  470 bits (1209), Expect = e-130
 Identities = 276/760 (36%), Positives = 410/760 (53%), Gaps = 43/760 (5%)

Query: 51  MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 110
           M +G  ++KVRS S    RY+ L  D  ++          K    I  ++ VR G  +++
Sbjct: 25  MQKGMLMRKVRSKSWKKLRYYRLQDDGMTVWHARQAGGRAKPSFSISDVETVRGGHESEL 84

Query: 111 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 170
            R+  ++++   +  F++++     +LDLVANS + A +W+ GL+ L+ +      +   
Sbjct: 85  LRN--LAEEFPLEQGFTIVFHGRRSNLDLVANSVEEAQVWMQGLQLLVDF------VTNM 136

Query: 171 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 230
            Q      W+S  F   D +  G ++     + +  +N  +     E  F+    +    
Sbjct: 137 DQQERLDQWLSDWFQRGDKNQDGRMSFGEVQRLLHLMNVEMDQ---EHAFQLFQTADTSQ 193

Query: 231 GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISL 290
              +  EEF+E +  L  R E+  L   FSS+ + L   + + FL+ EQ       +++L
Sbjct: 194 SGTLEGEEFVEFYKSLTKRAEVQELFENFSSDGQKLTLLEFVDFLQEEQKEGERASDLAL 253

Query: 291 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHN 350
           E+I ++EPS  G+ +  LS+DGF +YL S D  IF+P    + QDM QPL+HYFINSSHN
Sbjct: 254 ELIDRHEPSDSGKLRHVLSLDGFLSYLCSKDGDIFNPTCLPIYQDMTQPLNHYFINSSHN 313

Query: 351 TYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDI 410
           TYL+ DQ  G S + GYIRALK GCR VE+D+WDGP+ EPV+Y GHT+TS+I F+ V+  
Sbjct: 314 TYLVGDQLCGQSSVEGYIRALKRGCRCVEVDIWDGPNGEPVVYHGHTLTSRIPFKDVVAA 373

Query: 411 INKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVE-ESYLPSPDVX 469
           I +YAF  S+YP+IL LENHCS             +LG++L +T+ + +  + LPSP+  
Sbjct: 374 IAQYAFQTSDYPVILSLENHCSWEQQEMIAHHLTEILGEQLLSTTLDGQLPTQLPSPEEL 433

Query: 470 XXXXXXXXXXXSSNCSGVEGDVTD--------------------EDEGAEMSQRMGKENM 509
                       +    +E +  +                    E E  E+S R      
Sbjct: 434 RRKILVKGKKLRTLEEDLEEEEEEPEESELEGEQEAELELEAQFESEPQELSPR------ 487

Query: 510 EQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENP 569
              +     +  LC  LS LV   K+V F  F  S +  +++E+ SF+E  A     E+ 
Sbjct: 488 -SKDKKKKVKAILCPALSALVVYLKAVSFYSFAHSREHYRFYEISSFSEAKAKSLIKESG 546

Query: 570 GDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQN 629
            +FV +N   L+RV+P  +R DSSN NPQ+FW  GCQ+VAMN QT GL MDL  G FRQN
Sbjct: 547 NEFVQHNTWQLSRVYPGGLRTDSSNYNPQEFWNAGCQMVAMNMQTAGLEMDLCDGLFRQN 606

Query: 630 GNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDP 689
             CGYVL+P  +R+  S F  + +  +     Q L I++ISGQ  PK   S  +G +VDP
Sbjct: 607 AGCGYVLKPDFLRDAQSSF--HPERPISPSKAQTLLIQVISGQQLPKVDDS-KEGSIVDP 663

Query: 690 YVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DE 748
            V VEI G+  D A Q T  V  NG  P + ++  F++ +PELA++RFVV D D+   ++
Sbjct: 664 LVRVEIFGVRPDTARQETSYVENNGFNPYWGQTLCFRVLVPELALLRFVVKDYDWKSRND 723

Query: 749 FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           F+GQYT+P+ C+Q GYRH+ L S  G  L  AS+FVH+ I
Sbjct: 724 FVGQYTLPWNCMQQGYRHIHLLSKDGISLHPASIFVHICI 763



>gi|108854|pir||S14113   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase  (EC
           3.1.4.11) delta-2 - bovine
          Length = 764

 Score =  468 bits (1205), Expect = e-130
 Identities = 274/755 (36%), Positives = 407/755 (53%), Gaps = 38/755 (5%)

Query: 51  MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 110
           M +G+ ++KVRS S    R+F L  D  ++          K    I  +  VR G  +++
Sbjct: 18  MQKGTMMRKVRSKSWKKLRFFRLQDDGMTVWHARQAGGRAKPSFSISDVDTVREGHESEL 77

Query: 111 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 170
            R+  ++++   +  F++++     +LDLVANS   A  W+ GL+ L+ +      +   
Sbjct: 78  LRN--LAEEFPLEQGFTIVFHGRRSNLDLVANSVQEAQTWMQGLQLLVGF------VTNM 129

Query: 171 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 230
            Q      W+S  F   D +  G ++     + +  +N  +     E  F+    +    
Sbjct: 130 DQQERLDQWLSDWFQRGDKNQDGRMSFGEVQRLLHLMNVEMDQ---EYAFQLFQTADTSQ 186

Query: 231 GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISL 290
              +  EEF+E +  L  RPE+  L  +FSS+ + L   + + FL+ EQ       +++L
Sbjct: 187 SGTLEGEEFVEFYKSLTQRPEVQELFEKFSSDGQKLTLLEFVDFLQEEQKEGERASDLAL 246

Query: 291 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHN 350
           E+I +YEPS+ G+ +  LS+DGF  YL S D  IF+P    + QDM QPL+HY+INSSHN
Sbjct: 247 ELIDRYEPSESGKLRHVLSMDGFLGYLCSKDGDIFNPTCHPLYQDMTQPLNHYYINSSHN 306

Query: 351 TYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDI 410
           TYL+ DQ  G S + GYIRALK GCR VE+D+WDGP  EP++Y GHT+TS+I F+ V+  
Sbjct: 307 TYLVGDQLCGQSSVEGYIRALKRGCRCVEVDIWDGPSGEPIVYHGHTLTSRIPFKDVVAA 366

Query: 411 INKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVE-ESYLPSPD-- 467
           I +YAF  S+YP+IL LENHCS             +LGD+L TT+ + +  + LPSP+  
Sbjct: 367 IGQYAFQTSDYPVILSLENHCSWEQQEIIVRHLTEILGDQLLTTALDGQPPTQLPSPEDL 426

Query: 468 ------------VXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNV 515
                       +            +   + ++ +   E E  ++S R  ++  ++P  +
Sbjct: 427 RGKILVKGKKLMLEEEEEEPEAELEAEQEARLDLEAQLESEPQDLSPR-SEDKKKKPKAI 485

Query: 516 PVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNY 575
                 LC  LS LV   K+V F  F  S +   ++E  SF+E  A     E   +FV +
Sbjct: 486 ------LCPALSALVVYLKAVTFYSFTHSREHYHFYETSSFSETKAKSLIKEAGDEFVQH 539

Query: 576 NKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYV 635
           N   L+RV+PS +R DSSN NPQ+FW  GCQ+VAMN QT GL MDL  G FRQN  CGYV
Sbjct: 540 NAWQLSRVYPSGLRTDSSNYNPQEFWNAGCQMVAMNMQTAGLEMDLCDGLFRQNAGCGYV 599

Query: 636 LRPAIMREEVSFFSANTKDSVPGVSPQLLH---IKIISGQNFPKPKGSGAKGDVVDPYVY 692
           L+P  +R+  S F      S       ++    +++ISGQ  PK   +  +  +VDP V 
Sbjct: 600 LKPDFLRDAQSSFHPERPISPFKAQTLIIQEPWLQVISGQQLPKVDNTKEQ-SIVDPLVR 658

Query: 693 VEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIG 751
           VEI G+  D   Q T  V  NG  P + ++  F+I +PELA++RFVV D D+   ++FIG
Sbjct: 659 VEIFGVRPDTTRQETSYVENNGFNPYWGQTLCFRILVPELALLRFVVKDYDWKSRNDFIG 718

Query: 752 QYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHV 786
           QYT+P+ C+Q GYRH+ L S  G  L  AS+FVH+
Sbjct: 719 QYTLPWSCMQQGYRHIHLLSKDGLSLHPASIFVHI 753



>gi|206220|gb|AAA41886.1|   phospholipase C-III
          Length = 756

 Score =  462 bits (1190), Expect = e-128
 Identities = 276/754 (36%), Positives = 416/754 (55%), Gaps = 31/754 (4%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S   A  WV GLR +I +   +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +        F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSL 425

Query: 464 PSPD-----VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENME-QPNNVP 516
           PSP+     +            +   +G E  DV+DE E AEM     +  ++ +P    
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKE-- 483

Query: 517 VKRFQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNY 575
             + +L  ELS+++  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +
Sbjct: 484 -DKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRH 542

Query: 576 NKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYV 635
           N   L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYV
Sbjct: 543 NVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYV 602

Query: 636 LRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEI 695
           L+PA +R+  + F++      P   P+ L ++IISGQ  PK   +  K  +VDP V VEI
Sbjct: 603 LKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKN--KNSIVDPKVIVEI 660

Query: 696 HGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYT 754
           HG+  D   ++T  +  NG  P +D  FEF++ +P+LA+VRF+V D D    ++FIGQ T
Sbjct: 661 HGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQST 720

Query: 755 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           IP+  L+ GYRHV L S  G+    A+LFV ++I
Sbjct: 721 IPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISI 754



>gi|91898|pir||B28821   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase  (EC
           3.1.4.11) delta-1 - rat
          Length = 756

 Score =  462 bits (1190), Expect = e-128
 Identities = 276/754 (36%), Positives = 416/754 (55%), Gaps = 31/754 (4%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S   A  WV GLR +I +   +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +        F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSL 425

Query: 464 PSPD-----VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENME-QPNNVP 516
           PSP+     +            +   +G E  DV+DE E AEM     +  ++ +P    
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKE-- 483

Query: 517 VKRFQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNY 575
             + +L  ELS+++  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +
Sbjct: 484 -DKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRH 542

Query: 576 NKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYV 635
           N   L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYV
Sbjct: 543 NVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYV 602

Query: 636 LRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEI 695
           L+PA +R+  + F++      P   P+ L ++IISGQ  PK   +  K  +VDP V VEI
Sbjct: 603 LKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKN--KNSIVDPKVIVEI 660

Query: 696 HGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYT 754
           HG+  D   ++T  +  NG  P +D  FEF++ +P+LA+VRF+V D D    ++FIGQ T
Sbjct: 661 HGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQST 720

Query: 755 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           IP+  L+ GYRHV L S  G+    A+LFV ++I
Sbjct: 721 IPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISI 754



>gi|130228|sp|P10688|PID1_RAT   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1
           (Phosphoinositide phospholipase C) (PLC-delta-1)
           (Phospholipase C-delta-1) (PLC-III)
          Length = 756

 Score =  462 bits (1190), Expect = e-128
 Identities = 276/754 (36%), Positives = 416/754 (55%), Gaps = 31/754 (4%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S   A  WV GLR +I +   +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +        F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSL 425

Query: 464 PSPD-----VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENME-QPNNVP 516
           PSP+     +            +   +G E  DV+DE E AEM     +  ++ +P    
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKE-- 483

Query: 517 VKRFQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNY 575
             + +L  ELS+++  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +
Sbjct: 484 -DKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRH 542

Query: 576 NKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYV 635
           N   L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYV
Sbjct: 543 NVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYV 602

Query: 636 LRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEI 695
           L+PA +R+  + F++      P   P+ L ++IISGQ  PK   +  K  +VDP V VEI
Sbjct: 603 LKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKN--KNSIVDPKVIVEI 660

Query: 696 HGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYT 754
           HG+  D   ++T  +  NG  P +D  FEF++ +P+LA+VRF+V D D    ++FIGQ T
Sbjct: 661 HGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQST 720

Query: 755 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           IP+  L+ GYRHV L S  G+    A+LFV ++I
Sbjct: 721 IPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISI 754



>gi|8393981|ref|NP_058731.1|   phospholipase C, delta 1; Phospholipase C-delta1 [Rattus
           norvegicus]
          Length = 756

 Score =  462 bits (1190), Expect = e-128
 Identities = 276/754 (36%), Positives = 416/754 (55%), Gaps = 31/754 (4%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S   A  WV GLR +I +   +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +        F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSL 425

Query: 464 PSPD-----VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENME-QPNNVP 516
           PSP+     +            +   +G E  DV+DE E AEM     +  ++ +P    
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKE-- 483

Query: 517 VKRFQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNY 575
             + +L  ELS+++  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +
Sbjct: 484 -DKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRH 542

Query: 576 NKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYV 635
           N   L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYV
Sbjct: 543 NVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYV 602

Query: 636 LRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEI 695
           L+PA +R+  + F++      P   P+ L ++IISGQ  PK   +  K  +VDP V VEI
Sbjct: 603 LKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKN--KNSIVDPKVIVEI 660

Query: 696 HGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYT 754
           HG+  D   ++T  +  NG  P +D  FEF++ +P+LA+VRF+V D D    ++FIGQ T
Sbjct: 661 HGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQST 720

Query: 755 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           IP+  L+ GYRHV L S  G+    A+LFV ++I
Sbjct: 721 IPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISI 754



>gi|4099291|gb|AAD00570.1|   phospholipase C delta-1; PI-PLC-delta-1 [Mus musculus]
          Length = 756

 Score =  454 bits (1169), Expect = e-126
 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S      WV GLR +I     +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+ + T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425

Query: 464 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 519
           PSP+                    G  G + TD  +  E ++   +    Q  + P + +
Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+  + F++      P  +P+ L + IISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  FEF + +P+LA+VRF+V D D    ++FIGQ TIP+
Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G++   A+LFV ++I
Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754



>gi|4894788|gb|AAD32616.1|AF133125_1   phospholipase C delta-1 [Mus musculus]
          Length = 756

 Score =  454 bits (1169), Expect = e-126
 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S      WV GLR +I     +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+ + T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425

Query: 464 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 519
           PSP+                    G  G + TD  +  E ++   +    Q  + P + +
Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+  + F++      P  +P+ L + IISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  FEF + +P+LA+VRF+V D D    ++FIGQ TIP+
Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G++   A+LFV ++I
Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754



>gi|26324684|dbj|BAC26096.1|   unnamed protein product [Mus musculus]
          Length = 756

 Score =  454 bits (1169), Expect = e-126
 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S      WV GLR +I     +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+ + T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425

Query: 464 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 519
           PSP+                    G  G + TD  +  E ++   +    Q  + P + +
Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+  + F++      P  +P+ L + IISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  FEF + +P+LA+VRF+V D D    ++FIGQ TIP+
Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G++   A+LFV ++I
Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754



>gi|26350063|dbj|BAC38671.1|   unnamed protein product [Mus musculus]
          Length = 756

 Score =  454 bits (1169), Expect = e-126
 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S      WV GLR +I     +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+ + T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425

Query: 464 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 519
           PSP+                    G  G + TD  +  E ++   +    Q  + P + +
Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+  + F++      P  +P+ L + IISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  FEF + +P+LA+VRF+V D D    ++FIGQ TIP+
Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G++   A+LFV ++I
Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754



>gi|9790167|ref|NP_062650.1|   phospholipase C, delta; PLC-delta 1; phospholipase C delta-1 [Mus
           musculus]
          Length = 756

 Score =  454 bits (1169), Expect = e-126
 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S      WV GLR +I     +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+ + T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425

Query: 464 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 519
           PSP+                    G  G + TD  +  E ++   +    Q  + P + +
Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+  + F++      P  +P+ L + IISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  FEF + +P+LA+VRF+V D D    ++FIGQ TIP+
Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G++   A+LFV ++I
Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754



>gi|23396799|sp|Q8R3B1|PID1_MOUSE   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1
           (Phosphoinositide phospholipase C) (PLC-delta-1)
           (Phospholipase C-delta-1) (PLC-III)
          Length = 756

 Score =  454 bits (1168), Expect = e-126
 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S      WV GLR +I     +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+ + T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRVEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425

Query: 464 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 519
           PSP+                    G  G + TD  +  E ++   +    Q  + P + +
Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+  + F++      P  +P+ L + IISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  FEF + +P+LA+VRF+V D D    ++FIGQ TIP+
Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G++   A+LFV ++I
Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754



>gi|19387967|gb|AAH25798.1|   phospholipase C, delta [Mus musculus]
          Length = 756

 Score =  454 bits (1168), Expect = e-126
 Identities = 275/751 (36%), Positives = 411/751 (54%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S      WV GLR +I     +
Sbjct: 78  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+ + T R EI     + + + E L  + L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIETFYRMLTQRVEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEE 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSL 425

Query: 464 PSPD--VXXXXXXXXXXXXSSNCSGVEG-DVTDEDEGAEMSQRMGKENMEQPNNVPVK-R 519
           PSP+                    G  G + TD  +  E ++   +    Q  + P + +
Sbjct: 426 PSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+  + F++      P  +P+ L + IISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKN--KNSIVDPKVIVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  FEF + +P+LA+VRF+V D D    ++FIGQ TIP+
Sbjct: 664 GQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPW 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G++   A+LFV ++I
Sbjct: 724 NSLKQGYRHVHLLSKNGDLHPSATLFVKISI 754



>gi|1245472|gb|AAA93481.1|   phospholipase C-delta1
          Length = 745

 Score =  452 bits (1164), Expect = e-125
 Identities = 278/753 (36%), Positives = 420/753 (55%), Gaps = 29/753 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 8   LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 66

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S+  A  WV GLR +I +   +
Sbjct: 67  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSSADAQHWVQGLRKIIHHSG-S 123

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 124 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDSYARKIFREC- 177

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI  +  + + + E L  + L+ FL+ +Q    
Sbjct: 178 ---DHSQTDSLEDEEIETFYKMLTQRAEIDRVFAEAAGSAETLSVEKLVTFLQHQQREEA 234

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 235 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMDQPLSHY 294

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 295 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 354

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +     L
Sbjct: 355 FYDVLRAIRDYAFKASPYPVILSLENHCSLEQQQVMARHLKAILGPMLLDQPLDGVTMSL 414

Query: 464 PSPD-----VXXXXXXXXXXXXSSNCSGVE-GDVTDEDEGAEMSQRMGKENMEQPNNVPV 517
           PSP+     +            +   +G E  DV+DEDE AEM     +  ++Q +    
Sbjct: 415 PSPEQLKGKILLKGKKFGGLLPAGGENGPETTDVSDEDEAAEMEDEAVRSQVQQKSK--E 472

Query: 518 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 576
            +  +  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+  +FV +N
Sbjct: 473 DKLNVAPELSDMVIYCKSVHFGGFSNPSTSGQAFYEMASFSENRALRLLQESGNNFVRHN 532

Query: 577 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 636
              L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL
Sbjct: 533 VSHLSRIYPAGRRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGRFQDNGACGYVL 592

Query: 637 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 696
           +PA +R+  + F+       P  + + L +++ISGQ  PK   S  K  +VDP V VE+H
Sbjct: 593 KPAFLRDPDTAFNPRALTQGPWWAQKRLRVRVISGQQLPKVNKS--KNSIVDPKVIVEVH 650

Query: 697 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTI 755
           G+  D A ++T  +  NG  P +D  FEF++ +P+LA+VRFVV D D    ++FIGQ TI
Sbjct: 651 GVGQDVASRQTAVITNNGFNPWWDTEFEFEVAVPDLALVRFVVEDYDASSKNDFIGQSTI 710

Query: 756 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           P+  L+ GYRHV L S  G+    A+LFV +++
Sbjct: 711 PWNSLKQGYRHVHLLSKNGDQHPSATLFVKISL 743



>gi|2137061|pir||PC4183   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase  (EC
           3.1.4.11) delta-1 - Chinese hamster (fragment)
          Length = 745

 Score =  452 bits (1164), Expect = e-125
 Identities = 278/753 (36%), Positives = 420/753 (55%), Gaps = 29/753 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 8   LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRM 66

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  I ED  FS+++ +   +LDL+A S+  A  WV GLR +I +   +
Sbjct: 67  GHRTEGLEK--FARDIPEDRCFSIVFKDQRNTLDLIAPSSADAQHWVQGLRKIIHHSG-S 123

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    +        ++ LN  +  S     F+E  
Sbjct: 124 MDQRQKLQ-----HWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDSYARKIFREC- 177

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI  +  + + + E L  + L+ FL+ +Q    
Sbjct: 178 ---DHSQTDSLEDEEIETFYKMLTQRAEIDRVFAEAAGSAETLSVEKLVTFLQHQQREEA 234

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 235 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMDQPLSHY 294

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 295 LVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 354

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHCS+            +LG  L     +     L
Sbjct: 355 FYDVLRAIRDYAFKASPYPVILSLENHCSLEQQQVMARHLKAILGPMLLDQPLDGVTMSL 414

Query: 464 PSPD-----VXXXXXXXXXXXXSSNCSGVE-GDVTDEDEGAEMSQRMGKENMEQPNNVPV 517
           PSP+     +            +   +G E  DV+DEDE AEM     +  ++Q +    
Sbjct: 415 PSPEQLKGKILLKGKKFGGLLPAGGENGPETTDVSDEDEAAEMEDEAVRSQVQQKSK--E 472

Query: 518 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 576
            +  +  ELS++V  CKSV F  F   S   Q ++E+ SF+E  A +   E+  +FV +N
Sbjct: 473 DKLNVAPELSDMVIYCKSVHFGGFSNPSTSGQAFYEMASFSENRALRLLQESGNNFVRHN 532

Query: 577 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 636
              L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ +G F+ NG CGYVL
Sbjct: 533 VSHLSRIYPAGRRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGRFQDNGACGYVL 592

Query: 637 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 696
           +PA +R+  + F+       P  + + L +++ISGQ  PK   S  K  +VDP V VE+H
Sbjct: 593 KPAFLRDPDTAFNPRALTQGPWWAQKRLRVRVISGQQLPKVNKS--KNSIVDPKVIVEVH 650

Query: 697 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTI 755
           G+  D A ++T  +  NG  P +D  FEF++ +P+LA+VRFVV D D    ++FIGQ TI
Sbjct: 651 GVGQDVASRQTAVITNNGFNPWWDTEFEFEVAVPDLALVRFVVEDYDASSKNDFIGQSTI 710

Query: 756 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           P+  L+ GYRHV L S  G+    A+LFV +++
Sbjct: 711 PWNSLKQGYRHVHLLSKNGDQHPSATLFVKISL 743



>gi|1587358|prf||2206431A   phospholipase C-delta4
          Length = 772

 Score =  451 bits (1159), Expect = e-125
 Identities = 279/775 (36%), Positives = 419/775 (54%), Gaps = 42/775 (5%)

Query: 39  KKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDS-EKAKIDIK 97
           +K+ + +  +  M +G+ ++KVR+ S    RYF L  D  ++ W     +S  K    I 
Sbjct: 6   QKLLTTNQDLLLMQKGTMMRKVRTKSWKKLRYFRLQDDGMTV-WHGRHLESISKPTFSIS 64

Query: 98  SIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYL 157
            ++ +R G+++++ R   + ++   +  F++++     +LDLVANS + A  W+ GL+ L
Sbjct: 65  DVERIRKGQDSELLRY--LVEEFPLEQGFTIVFNGRRPNLDLVANSVEEAQTWMRGLQLL 122

Query: 158 ISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIE 217
           +          +   D M   W    F + D +    ++   A + +  +N  +     E
Sbjct: 123 VDLVARM--NYQEQLDQMLREW----FQQADRNQDSRMSFREAQRLLLLMNVEMDE---E 173

Query: 218 LKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEA 277
             F    ++       +  EEF++ +  L  R EI  L   FSS+K+ L   + + FL  
Sbjct: 174 YAFSLFQEADVSQSNTLDSEEFVQFYKALTKRTEIEELFENFSSDKQKLTLLEFVDFLRE 233

Query: 278 EQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMK 337
           EQ  +  + +++L++I +YEPS+ G+    LS DGF +YL S D  IF+P+   + QDM 
Sbjct: 234 EQKESDHSSDLALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGNIFNPDCLPIYQDMT 293

Query: 338 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 397
           QPLSHY+INSSHNTYL+ DQF G S + GYIRALK GCR VE+D WDGPD EPV+Y G T
Sbjct: 294 QPLSHYYINSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGRT 353

Query: 398 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPN 457
           +TS+I+F+ V+  + +YAF +S+YPLIL L+NHC+             +LG++L +T+  
Sbjct: 354 LTSRILFKDVLATLAQYAFQSSDYPLILSLDNHCTWEQQKTMAHHLIAILGEQLLSTT-- 411

Query: 458 VEESY---LPSPDVXXXXXXXXXXXXSS---------NCSGVEGDVTDEDEG-AEMSQRM 504
           +EE     +PSP+              +              + + +D D   AE+  + 
Sbjct: 412 LEEQLIDIMPSPEQLRGKILVKGKKLRTIEVVESDKEEEELEKDEGSDLDPASAELDMQS 471

Query: 505 GKENMEQPNNVPVKRFQ----------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVC 554
             E+ EQ +    K  +          LC +LS LV   ++  F  F  S +    +++ 
Sbjct: 472 QPESQEQASGNKSKNKKKFLLQSSTTILCPDLSALVVYLRTAPFCSFTHSKENYHIYDIS 531

Query: 555 SFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQT 614
           SF+E  A     E   +FV +N R L RV+PS +R DSSN NPQ+ W  GCQ+VAMN QT
Sbjct: 532 SFSESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNVGCQMVAMNMQT 591

Query: 615 PGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNF 674
            G  MD+  G FRQNG  GYVL+P  +R+  S F  N    V     Q+L +++ISGQ  
Sbjct: 592 AGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSF--NPMKPVSLYKAQILVVQVISGQRL 649

Query: 675 PKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAM 734
           PK   +  +  VVDP V VE++G+P D  +Q T  V  NG  P + E+F FQI +PELAM
Sbjct: 650 PKVDKT-KETTVVDPLVRVELYGVPEDTKQQETSYVENNGINPYWGETFYFQIQVPELAM 708

Query: 735 VRFVVLDDDYIG-DEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           +RFVV D      + FIGQYT+P+ C++ GYRHV L S  G  L  AS+FV+  +
Sbjct: 709 LRFVVKDYSRTSRNNFIGQYTLPWTCMKHGYRHVSLLSKDGTSLHPASIFVYTCM 763



>gi|571466|gb|AAC52346.1|   phospholipase C delta-4
          Length = 772

 Score =  451 bits (1159), Expect = e-125
 Identities = 279/775 (36%), Positives = 419/775 (54%), Gaps = 42/775 (5%)

Query: 39  KKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDS-EKAKIDIK 97
           +K+ + +  +  M +G+ ++KVR+ S    RYF L  D  ++ W     +S  K    I 
Sbjct: 6   QKLLTTNQDLLLMQKGTMMRKVRTKSWKKLRYFRLQDDGMTV-WHGRHLESISKPTFSIS 64

Query: 98  SIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYL 157
            ++ +R G+++++ R   + ++   +  F++++     +LDLVANS + A  W+ GL+ L
Sbjct: 65  DVERIRKGQDSELLRY--LVEEFPLEQGFTIVFNGRRPNLDLVANSVEEAQTWMRGLQLL 122

Query: 158 ISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIE 217
           +          +   D M   W    F + D +    ++   A + +  +N  +     E
Sbjct: 123 VDLVARM--NYQEQLDQMLREW----FQQADRNQDSRMSFREAQRLLLLMNVEMDE---E 173

Query: 218 LKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEA 277
             F    ++       +  EEF++ +  L  R EI  L   FSS+K+ L   + + FL  
Sbjct: 174 YAFSLFQEADVSQSNTLDSEEFVQFYKALTKRTEIEELFENFSSDKQKLTLLEFVDFLRE 233

Query: 278 EQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMK 337
           EQ  +  + +++L++I +YEPS+ G+    LS DGF +YL S D  IF+P+   + QDM 
Sbjct: 234 EQKESDHSSDLALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGNIFNPDCLPIYQDMT 293

Query: 338 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 397
           QPLSHY+INSSHNTYL+ DQF G S + GYIRALK GCR VE+D WDGPD EPV+Y G T
Sbjct: 294 QPLSHYYINSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGRT 353

Query: 398 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPN 457
           +TS+I+F+ V+  + +YAF +S+YPLIL L+NHC+             +LG++L +T+  
Sbjct: 354 LTSRILFKDVLATLAQYAFQSSDYPLILSLDNHCTWEQQKTMAHHLIAILGEQLLSTT-- 411

Query: 458 VEESY---LPSPDVXXXXXXXXXXXXSS---------NCSGVEGDVTDEDEG-AEMSQRM 504
           +EE     +PSP+              +              + + +D D   AE+  + 
Sbjct: 412 LEEQLIDIMPSPEQLRGKILVKGKKLRTIEVVESDKEEEELEKDEGSDLDPASAELDMQS 471

Query: 505 GKENMEQPNNVPVKRFQ----------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVC 554
             E+ EQ +    K  +          LC +LS LV   ++  F  F  S +    +++ 
Sbjct: 472 QPESQEQASGNKSKNKKKFLLQSSTTILCPDLSALVVYLRTAPFCSFTHSKENYHIYDIS 531

Query: 555 SFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQT 614
           SF+E  A     E   +FV +N R L RV+PS +R DSSN NPQ+ W  GCQ+VAMN QT
Sbjct: 532 SFSESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNVGCQMVAMNMQT 591

Query: 615 PGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNF 674
            G  MD+  G FRQNG  GYVL+P  +R+  S F  N    V     Q+L +++ISGQ  
Sbjct: 592 AGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSF--NPMKPVSLYKAQILVVQVISGQRL 649

Query: 675 PKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAM 734
           PK   +  +  VVDP V VE++G+P D  +Q T  V  NG  P + E+F FQI +PELAM
Sbjct: 650 PKVDKT-KETTVVDPLVRVELYGVPEDTKQQETSYVENNGINPYWGETFYFQIQVPELAM 708

Query: 735 VRFVVLDDDYIG-DEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           +RFVV D      + FIGQYT+P+ C++ GYRHV L S  G  L  AS+FV+  +
Sbjct: 709 LRFVVKDYSRTSRNNFIGQYTLPWTCMKHGYRHVSLLSKDGTSLHPASIFVYTCM 763



>gi|18093100|ref|NP_542419.1|   phospholipase C, delta 4 [Rattus norvegicus]
          Length = 772

 Score =  451 bits (1159), Expect = e-125
 Identities = 279/775 (36%), Positives = 419/775 (54%), Gaps = 42/775 (5%)

Query: 39  KKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDS-EKAKIDIK 97
           +K+ + +  +  M +G+ ++KVR+ S    RYF L  D  ++ W     +S  K    I 
Sbjct: 6   QKLLTTNQDLLLMQKGTMMRKVRTKSWKKLRYFRLQDDGMTV-WHGRHLESISKPTFSIS 64

Query: 98  SIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYL 157
            ++ +R G+++++ R   + ++   +  F++++     +LDLVANS + A  W+ GL+ L
Sbjct: 65  DVERIRKGQDSELLRY--LVEEFPLEQGFTIVFNGRRPNLDLVANSVEEAQTWMRGLQLL 122

Query: 158 ISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIE 217
           +          +   D M   W    F + D +    ++   A + +  +N  +     E
Sbjct: 123 VDLVARM--NYQEQLDQMLREW----FQQADRNQDSRMSFREAQRLLLLMNVEMDE---E 173

Query: 218 LKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEA 277
             F    ++       +  EEF++ +  L  R EI  L   FSS+K+ L   + + FL  
Sbjct: 174 YAFSLFQEADVSQSNTLDSEEFVQFYKALTKRTEIEELFENFSSDKQKLTLLEFVDFLRE 233

Query: 278 EQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMK 337
           EQ  +  + +++L++I +YEPS+ G+    LS DGF +YL S D  IF+P+   + QDM 
Sbjct: 234 EQKESDHSSDLALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGNIFNPDCLPIYQDMT 293

Query: 338 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 397
           QPLSHY+INSSHNTYL+ DQF G S + GYIRALK GCR VE+D WDGPD EPV+Y G T
Sbjct: 294 QPLSHYYINSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGRT 353

Query: 398 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPN 457
           +TS+I+F+ V+  + +YAF +S+YPLIL L+NHC+             +LG++L +T+  
Sbjct: 354 LTSRILFKDVLATLAQYAFQSSDYPLILSLDNHCTWEQQKTMAHHLIAILGEQLLSTT-- 411

Query: 458 VEESY---LPSPDVXXXXXXXXXXXXSS---------NCSGVEGDVTDEDEG-AEMSQRM 504
           +EE     +PSP+              +              + + +D D   AE+  + 
Sbjct: 412 LEEQLIDIMPSPEQLRGKILVKGKKLRTIEVVESDKEEEELEKDEGSDLDPASAELDMQS 471

Query: 505 GKENMEQPNNVPVKRFQ----------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVC 554
             E+ EQ +    K  +          LC +LS LV   ++  F  F  S +    +++ 
Sbjct: 472 QPESQEQASGNKSKNKKKFLLQSSTTILCPDLSALVVYLRTAPFCSFTHSKENYHIYDIS 531

Query: 555 SFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQT 614
           SF+E  A     E   +FV +N R L RV+PS +R DSSN NPQ+ W  GCQ+VAMN QT
Sbjct: 532 SFSESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNVGCQMVAMNMQT 591

Query: 615 PGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNF 674
            G  MD+  G FRQNG  GYVL+P  +R+  S F  N    V     Q+L +++ISGQ  
Sbjct: 592 AGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSF--NPMKPVSLYKAQILVVQVISGQRL 649

Query: 675 PKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAM 734
           PK   +  +  VVDP V VE++G+P D  +Q T  V  NG  P + E+F FQI +PELAM
Sbjct: 650 PKVDKT-KETTVVDPLVRVELYGVPEDTKQQETSYVENNGINPYWGETFYFQIQVPELAM 708

Query: 735 VRFVVLDDDYIG-DEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           +RFVV D      + FIGQYT+P+ C++ GYRHV L S  G  L  AS+FV+  +
Sbjct: 709 LRFVVKDYSRTSRNNFIGQYTLPWTCMKHGYRHVSLLSKDGTSLHPASIFVYTCM 763



>gi|1304189|dbj|BAA09046.1|   phodpholipase C delta4 [Rattus norvegicus]
          Length = 771

 Score =  449 bits (1156), Expect = e-124
 Identities = 277/772 (35%), Positives = 417/772 (54%), Gaps = 37/772 (4%)

Query: 39  KKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDS-EKAKIDIK 97
           +K+ + +  +  M +G+ ++KVR+ S    RYF L  D  ++ W     +S  K    I 
Sbjct: 6   QKLLTTNQDLLLMQKGTMMRKVRTKSWKKLRYFRLQDDGMTV-WHGRHLESISKPTFSIS 64

Query: 98  SIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYL 157
            ++ +R G+++++ R   + ++   +  F++++     +LDLVANS + A  W+ GL+ L
Sbjct: 65  DVERIRKGQDSELLRY--LVEEFPLEQGFTIVFNGRRPNLDLVANSVEEAQTWMRGLQLL 122

Query: 158 ISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIE 217
           +          +   D M   W    F + D +    ++   A + +  +N  +     E
Sbjct: 123 VDLVARM--NYQEQLDQMLREW----FQQADRNQDSRMSFREAQRLLLLMNVEMDE---E 173

Query: 218 LKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEA 277
             F    ++       +  EEF++ +  L  R EI  L   FSS+K+ L   + + FL  
Sbjct: 174 YAFSLFQEADVSQSNTLDSEEFVQFYKALTKRTEIEELFENFSSDKQKLTLLEFVDFLRE 233

Query: 278 EQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMK 337
           EQ  +  + +++L++I +YEPS+ G+    LS DGF +YL S D  IF+P+   + QDM 
Sbjct: 234 EQKESDHSSDLALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGNIFNPDCLPIYQDMT 293

Query: 338 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 397
           QPLSHY+INSSHNTYL+ DQF G S + GYIRALK GCR VE+D WDGPD EPV+Y G T
Sbjct: 294 QPLSHYYINSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGRT 353

Query: 398 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSI-XXXXXXXXXXXXLLGDKLYTTSP 456
           +TS+I+F+ V+  + +YAF +S+YPLIL L+NHC+              +LG++L +T+ 
Sbjct: 354 LTSRILFKDVLATLAQYAFQSSDYPLILSLDNHCTWEQQKTMLAHHLIAILGEQLLSTTL 413

Query: 457 NVEESYLPSPDVXXXXXXXXXXXXSSNCSGVEGDV--------TDEDEG-AEMSQRMGKE 507
             +   +PSP++            +      + +         +D D   AE+  +   E
Sbjct: 414 EEQIDIMPSPELRGKILVKGKKLRTIEVVESDKEEEELEKDEGSDLDPASAELDMQSQPE 473

Query: 508 NMEQPNNVPVKRFQ----------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFN 557
           + EQ +    K  +          LC +LS LV   ++  F  F  S +    +++ SF+
Sbjct: 474 SQEQASGNKSKNKKKFLLQSSTTILCPDLSALVVYLRTAPFCSFTHSKENYHIYDISSFS 533

Query: 558 EVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGL 617
           E  A     E   +FV +N R L RV+PS +R DSSN NPQ+ W  GCQ+VAMN QT G 
Sbjct: 534 ESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNVGCQMVAMNMQTAGS 593

Query: 618 MMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKP 677
            MD+  G FRQNG  GYVL+P  +R+  S F  N    V     Q+L +++ISGQ  PK 
Sbjct: 594 AMDICDGLFRQNGGSGYVLKPEFLRDTQSSF--NPMKPVSLYKAQILVVQVISGQRLPKV 651

Query: 678 KGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRF 737
             +  +  VVDP V VE++G+P D  +Q T  V  NG  P + E+F FQI +PELAM+RF
Sbjct: 652 DKT-KETTVVDPLVRVELYGVPEDTKQQETSYVENNGINPYWGETFYFQIQVPELAMLRF 710

Query: 738 VVLDDDYIG-DEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           VV D      + FIGQYT+P+ C++ GYRHV L S  G  L  AS FV+  +
Sbjct: 711 VVKDYSRTSRNNFIGQYTLPWTCMKHGYRHVSLLSKDGTSLHPASHFVYTCM 762



>gi|1150520|emb|CAA89822.1|   phospholipase C [Oryctolagus cuniculus]
          Length = 745

 Score =  445 bits (1145), Expect = e-123
 Identities = 277/749 (36%), Positives = 404/749 (53%), Gaps = 27/749 (3%)

Query: 51  MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRTGKN 107
           +++GS+L KV+S S    R+  L  D +++ W+ S+K     E     I+ I+EVR G  
Sbjct: 11  LLKGSQLLKVKSGSWRRERFLKLQEDCKTI-WQESRKVMRSPESQLFSIEDIQEVRVGHR 69

Query: 108 TDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDM 167
           T+       +  + ED  FS+++ +    LDL+A S   A  WV GLR +I +   ++D 
Sbjct: 70  TEGLEK--FARDVPEDRCFSIVFKDQRRPLDLIAPSPADAQHWVQGLRKVIHHSG-SMDQ 126

Query: 168 LESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSK 227
            +  Q      W+     + D +    ++       ++ LN  +        F+E     
Sbjct: 127 RQKLQ-----HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDGYARKIFREC---- 177

Query: 228 DKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 286
           D++ T+  ++E IE F+++ T R EI     + + + + L    L+ FL+ +Q       
Sbjct: 178 DRSQTDSLEDEEIEAFYKMLTQREEIDRAFAEAAGSGQTLSVDQLVGFLQHQQREEAAGP 237

Query: 287 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 346
            ++L +I +YEPS+  + +  ++ DGF  YL+S D   F  EH++V QDM QPLSHY ++
Sbjct: 238 ALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSREHRRVYQDMGQPLSHYLVS 297

Query: 347 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 406
           SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP  EPVIY G+T TS+I+F  
Sbjct: 298 SSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPSLEPVIYHGYTFTSKILFCD 357

Query: 407 VIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYLPSP 466
            +  I  YAF  S YP+IL LENHCS+            LLG  L     +   S LPSP
Sbjct: 358 ALRAIRDYAFKVSPYPVILSLENHCSLEQQRVMARHLRTLLGPMLLDRPLDGVTSSLPSP 417

Query: 467 D-----VXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQ 521
           +     +            S+   G E  V  +++ A   +     +  Q +     + +
Sbjct: 418 EQLKGKILLKGKKLGGLLPSAGEGGPEATVVSDEDEAAEMEDEAVRSRVQ-HQPKADKVR 476

Query: 522 LCKELSELVSICKSVQFKEFQVSFQVQK-YWEVCSFNEVLASKYANENPGDFVNYNKRFL 580
           L +ELS+LV  CKSV F  F      ++ ++E+ SF+E  A +   E+   FV +N   L
Sbjct: 477 LVQELSDLVIYCKSVHFDGFSSPGTPRRAFYEMMSFSENRALRLLQESGNSFVRHNVGHL 536

Query: 581 ARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAI 640
           +R++P   R DSSN +P D W  GCQIVA+NFQTPG  MD+  G F  NG CGYVL+PA 
Sbjct: 537 SRIYPPGWRTDSSNYSPVDMWNGGCQIVALNFQTPGPEMDVYQGRFLDNGACGYVLKPAF 596

Query: 641 MREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA 700
           +R+  + F+A      P  + + L I++ISGQ  PK   S  K  +VDP V VEIHG+  
Sbjct: 597 LRDPNTTFNARALAQGPWWARKRLSIRVISGQQLPKVNKS--KNSIVDPKVTVEIHGVSR 654

Query: 701 DCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPFEC 759
           D A ++T  V  NG  P +D  FEF++ +PELA+VRFVV D D    ++FIGQ TIP   
Sbjct: 655 DVASRQTAVVTNNGFNPRWDTEFEFEVVVPELALVRFVVEDYDPSSKNDFIGQSTIPLGS 714

Query: 760 LQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           L+ GY HV L S TG+    A+LFV +++
Sbjct: 715 LKQGYPHVHLLSKTGDQHPSATLFVKISL 743



>gi|89332|pir||C28821   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase  (EC
           3.1.4.11) delta-1 - bovine (fragments)
          Length = 709

 Score =  437 bits (1124), Expect = e-121
 Identities = 266/710 (37%), Positives = 388/710 (54%), Gaps = 23/710 (3%)

Query: 87  KDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADV 146
           ++ E     I+ I+EVR G  T+       +  + E+  FS+++ +   +LDL+A S   
Sbjct: 13  QEEESQLFSIEDIQEVRMGHRTEGLEK--FARDVPENRCFSIVFKDQRNTLDLIAPSPAD 70

Query: 147 ANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRN 206
           A  WV GL  +I    H+  M    Q  +R  W+     + D +    ++       ++ 
Sbjct: 71  AQHWVQGLGKII---HHSGSM--DQQQKLR-HWIHSCLRKADKNKDNKMSFKELQNFLKE 124

Query: 207 LNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEF 265
           LN  +  S     FKE     D + T+  ++E IE F+++ T R EI     + + +KE 
Sbjct: 125 LNIQVDDSYARKIFKEC----DHSQTDSLEDEEIETFYKILTQRKEIDRTFEEATGSKET 180

Query: 266 LDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 325
           L    L+ FL+ +Q        ++L +I +YEPS+  + +  ++ DGF  YL+S D   F
Sbjct: 181 LSVDQLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAF 240

Query: 326 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 385
           D   ++V QDM QPLSHY ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDG
Sbjct: 241 DLADRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDG 300

Query: 386 PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXX 445
           P+ EP+IY G+T TS+I+F  V+  I  YAF AS YP+IL LENHCS+            
Sbjct: 301 PNQEPIIYHGYTFTSKILFCDVVRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRT 360

Query: 446 LLGDKLYTTSPNVEESYLPSPD-----VXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEM 500
           LLG  L     +   + LPSP+     +                +G E  V  +++ A  
Sbjct: 361 LLGPMLLDRPLDGVVTSLPSPEQLRGKILLKGKKLGGLFPPGGENGPEATVVSDEDEAAE 420

Query: 501 SQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVS-FQVQKYWEVCSFNEV 559
            +     +  Q +     + +L KELS++V  CKSV F+ F  S    Q ++E+ SF+E 
Sbjct: 421 MEDEAVRSQVQ-HKSKEDKLRLAKELSDMVIYCKSVHFRGFPSSGTSGQAFYEMSSFSEN 479

Query: 560 LASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMM 619
            A +   E+   FV +N   L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  M
Sbjct: 480 RALRLLQESGNSFVRHNVNHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGSEM 539

Query: 620 DLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKG 679
           D+  G F  NG CGYVL+PA +R+  S F++      P  +P+ L++++ISGQ  PK   
Sbjct: 540 DVYQGRFLDNGACGYVLKPAFLRDPNSTFNSRALAHGPWWTPKRLNVRVISGQQLPKVNK 599

Query: 680 SGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVV 739
           +  K  +VDP V VEIHG+  D A ++T  V  NG  P +D   EF++ +PELA+VRFVV
Sbjct: 600 N--KNSIVDPKVTVEIHGVTGDVASRQTAVVTNNGFNPWWDTELEFEVAVPELALVRFVV 657

Query: 740 LD-DDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
            D D    ++FIGQ TIP + L+ GYRH+ L S  G+    A+LFV VA+
Sbjct: 658 EDYDASSKNDFIGQSTIPLKSLKQGYRHIHLLSKNGDQHPSATLFVKVAL 707



>gi|163538|gb|AAA30710.1|   phospholipase C-III
          Length = 695

 Score =  436 bits (1120), Expect = e-120
 Identities = 266/707 (37%), Positives = 385/707 (54%), Gaps = 23/707 (3%)

Query: 90  EKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANI 149
           E     I+ I+EVR G  T+       +  + E+  FS+++ +   +LDL+A S   A  
Sbjct: 2   ESQLFSIEDIQEVRMGHRTEGLEK--FARDVPENRCFSIVFKDQRNTLDLIAPSPADAQH 59

Query: 150 WVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNP 209
           WV GL  +I    H+  M    Q  +R  W+     + D +    ++       ++ LN 
Sbjct: 60  WVQGLGKII---HHSGSM--DQQQKLR-HWIHSCLRKADKNKDNKMSFKELQNFLKELNI 113

Query: 210 GLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDT 268
            +  S     FKE     D + T+  ++E IE F+++ T R EI     + + +KE L  
Sbjct: 114 QVDDSYARKIFKEC----DHSQTDSLEDEEIETFYKILTQRKEIDRTFEEATGSKETLSV 169

Query: 269 KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 328
             L+ FL+ +Q        ++L +I +YEPS+  + +  ++ DGF  YL+S D   FD  
Sbjct: 170 DQLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFDLA 229

Query: 329 HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 388
            ++V QDM QPLSHY ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ 
Sbjct: 230 DRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQ 289

Query: 389 EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLG 448
           EP+IY G+T TS+I+F  V+  I  YAF AS YP+IL LENHCS+            LLG
Sbjct: 290 EPIIYHGYTFTSKILFCDVVRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRTLLG 349

Query: 449 DKLYTTSPNVEESYLPSPD-----VXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQR 503
             L     +   + LPSP+     +                 G E  V  +++ A   + 
Sbjct: 350 PMLLDRPLDGVVTSLPSPEQLRGKILLKGKKLGGLFPPGGEGGPEATVVSDEDEAAEMED 409

Query: 504 MGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVS-FQVQKYWEVCSFNEVLAS 562
               +  Q +     + +L KELS++V  CKSV F+ F  S    Q ++E+ SF+E  A 
Sbjct: 410 EAVRSQVQ-HKSKEDKLRLAKELSDMVIYCKSVHFRGFPSSGTSGQAFYEMSSFSENRAL 468

Query: 563 KYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLN 622
           +   E+   FV +N   L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ 
Sbjct: 469 RLLQESGNSFVRHNVNHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGSEMDVY 528

Query: 623 IGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGA 682
            G F  NG CGYVL+PA +R+  S F++      P  +P+ L++++ISGQ  PK   +  
Sbjct: 529 QGRFLDNGACGYVLKPAFLRDPNSTFNSRALAHGPWWTPKRLNVRVISGQQLPKVNKN-- 586

Query: 683 KGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD- 741
           K  +VDP V VEIHG+  D A ++T  V  NG  P +D   EF++ +PELA+VRFVV D 
Sbjct: 587 KNSIVDPKVTVEIHGVTGDVASRQTAVVTNNGFNPWWDTELEFEVAVPELALVRFVVEDY 646

Query: 742 DDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           D    ++FIGQ TIP + L+ GYRH+ L S  G+    A+LFV VA+
Sbjct: 647 DASSKNDFIGQSTIPLKSLKQGYRHIHLLSKNGDQHPSATLFVKVAL 693



>gi|130227|sp|P10895|PID1_BOVIN   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1
           (Phosphoinositide phospholipase C) (PLC-delta-1)
           (Phospholipase C-delta-1) (PLC-III)
          Length = 695

 Score =  436 bits (1120), Expect = e-120
 Identities = 266/707 (37%), Positives = 385/707 (54%), Gaps = 23/707 (3%)

Query: 90  EKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANI 149
           E     I+ I+EVR G  T+       +  + E+  FS+++ +   +LDL+A S   A  
Sbjct: 2   ESQLFSIEDIQEVRMGHRTEGLEK--FARDVPENRCFSIVFKDQRNTLDLIAPSPADAQH 59

Query: 150 WVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNP 209
           WV GL  +I    H+  M    Q  +R  W+     + D +    ++       ++ LN 
Sbjct: 60  WVQGLGKII---HHSGSM--DQQQKLR-HWIHSCLRKADKNKDNKMSFKELQNFLKELNI 113

Query: 210 GLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDT 268
            +  S     FKE     D + T+  ++E IE F+++ T R EI     + + +KE L  
Sbjct: 114 QVDDSYARKIFKEC----DHSQTDSLEDEEIETFYKILTQRKEIDRTFEEATGSKETLSV 169

Query: 269 KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 328
             L+ FL+ +Q        ++L +I +YEPS+  + +  ++ DGF  YL+S D   FD  
Sbjct: 170 DQLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFDLA 229

Query: 329 HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 388
            ++V QDM QPLSHY ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ 
Sbjct: 230 DRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQ 289

Query: 389 EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLG 448
           EP+IY G+T TS+I+F  V+  I  YAF AS YP+IL LENHCS+            LLG
Sbjct: 290 EPIIYHGYTFTSKILFCDVVRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRTLLG 349

Query: 449 DKLYTTSPNVEESYLPSPD-----VXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQR 503
             L     +   + LPSP+     +                 G E  V  +++ A   + 
Sbjct: 350 PMLLDRPLDGVVTSLPSPEQLRGKILLKGKKLGGLFPPGGEGGPEATVVSDEDEAAEMED 409

Query: 504 MGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVS-FQVQKYWEVCSFNEVLAS 562
               +  Q +     + +L KELS++V  CKSV F+ F  S    Q ++E+ SF+E  A 
Sbjct: 410 EAVRSQVQ-HKSKEDKLRLAKELSDMVIYCKSVHFRGFPSSGTSGQAFYEMSSFSENRAL 468

Query: 563 KYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLN 622
           +   E+   FV +N   L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+ 
Sbjct: 469 RLLQESGNSFVRHNVNHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGSEMDVY 528

Query: 623 IGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGA 682
            G F  NG CGYVL+PA +R+  S F++      P  +P+ L++++ISGQ  PK   +  
Sbjct: 529 QGRFLDNGACGYVLKPAFLRDPNSTFNSRALAHGPWWTPKRLNVRVISGQQLPKVNKN-- 586

Query: 683 KGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD- 741
           K  +VDP V VEIHG+  D A ++T  V  NG  P +D   EF++ +PELA+VRFVV D 
Sbjct: 587 KNSIVDPKVTVEIHGVTGDVASRQTAVVTNNGFNPWWDTELEFEVAVPELALVRFVVEDY 646

Query: 742 DDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           D    ++FIGQ TIP + L+ GYRH+ L S  G+    A+LFV VA+
Sbjct: 647 DASSKNDFIGQSTIPLKSLKQGYRHIHLLSKNGDQHPSATLFVKVAL 693



>gi|483920|gb|AAA73567.1|   phospholipase c delta 1
          Length = 756

 Score =  432 bits (1110), Expect = e-119
 Identities = 263/751 (35%), Positives = 402/751 (53%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  + ED  FS+++ +   +LDL+A S   A  WV GL  +I +   +
Sbjct: 78  GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    ++       ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + +   E L    L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGPGETLSVDQLVTFLQHQQREEA 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETTKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHC++            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 425

Query: 464 PSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVK----R 519
           PSP+                         +    ++  +    E+    + V  K    +
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L +ELS++V  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+    F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQDRFQDNGACGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+    F+       P  + + L+I++ISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  F F++ +P+LA++RF+V D D    ++FIGQ TIP 
Sbjct: 664 SRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPL 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G+    A+LFV +++
Sbjct: 724 NSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754



>gi|1082691|pir||A55943   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase  (EC
           3.1.4.11) delta-1 [validated] - human
          Length = 756

 Score =  432 bits (1110), Expect = e-119
 Identities = 263/751 (35%), Positives = 402/751 (53%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  + ED  FS+++ +   +LDL+A S   A  WV GL  +I +   +
Sbjct: 78  GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    ++       ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + +   E L    L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGPGETLSVDQLVTFLQHQQREEA 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETTKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHC++            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 425

Query: 464 PSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVK----R 519
           PSP+                         +    ++  +    E+    + V  K    +
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L +ELS++V  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+    F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQDRFQDNGACGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+    F+       P  + + L+I++ISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  F F++ +P+LA++RF+V D D    ++FIGQ TIP 
Sbjct: 664 SRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPL 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G+    A+LFV +++
Sbjct: 724 NSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754



>gi|1730575|sp|P51178|PID1_HUMAN   1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1
           (Phosphoinositide phospholipase C) (PLC-delta-1)
           (Phospholipase C-delta-1) (PLC-III)
          Length = 756

 Score =  432 bits (1110), Expect = e-119
 Identities = 263/751 (35%), Positives = 402/751 (53%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  + ED  FS+++ +   +LDL+A S   A  WV GL  +I +   +
Sbjct: 78  GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    ++       ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + +   E L    L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGPGETLSVDQLVTFLQHQQREEA 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETTKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHC++            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 425

Query: 464 PSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVK----R 519
           PSP+                         +    ++  +    E+    + V  K    +
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L +ELS++V  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+    F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQDRFQDNGACGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+    F+       P  + + L+I++ISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  F F++ +P+LA++RF+V D D    ++FIGQ TIP 
Sbjct: 664 SRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPL 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G+    A+LFV +++
Sbjct: 724 NSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754



>gi|5453910|ref|NP_006216.1|   phospholipase C, delta 1 [Homo sapiens]
          Length = 756

 Score =  432 bits (1110), Expect = e-119
 Identities = 263/751 (35%), Positives = 402/751 (53%), Gaps = 25/751 (3%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 104
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77

Query: 105 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 164
           G  T+       +  + ED  FS+++ +   +LDL+A S   A  WV GL  +I +   +
Sbjct: 78  GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 134

Query: 165 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 224
           +D  +  Q      W+     + D +    ++       ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQ-----HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 188

Query: 225 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 283
              D + T+  ++E IE F+++ T R EI     + +   E L    L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGPGETLSVDQLVTFLQHQQREEA 245

Query: 284 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 343
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETTKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 305

Query: 344 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 403
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 404 FRSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTTSPNVEESYL 463
           F  V+  I  YAF AS YP+IL LENHC++            +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 425

Query: 464 PSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVK----R 519
           PSP+                         +    ++  +    E+    + V  K    +
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDK 485

Query: 520 FQLCKELSELVSICKSVQFKEFQV-SFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKR 578
            +L +ELS++V  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +N  
Sbjct: 486 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 545

Query: 579 FLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRP 638
            L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+    F+ NG CGYVL+P
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQDRFQDNGACGYVLKP 605

Query: 639 AIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGI 698
           A +R+    F+       P  + + L+I++ISGQ  PK   +  K  +VDP V VEIHG+
Sbjct: 606 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIHGV 663

Query: 699 PADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLD-DDYIGDEFIGQYTIPF 757
             D A ++T  +  NG  P +D  F F++ +P+LA++RF+V D D    ++FIGQ TIP 
Sbjct: 664 SRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPL 723

Query: 758 ECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
             L+ GYRHV L S  G+    A+LFV +++
Sbjct: 724 NSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754



>gi|21740077|emb|CAD39054.1|   hypothetical protein [Homo sapiens]
          Length = 737

 Score =  427 bits (1098), Expect = e-118
 Identities = 267/755 (35%), Positives = 390/755 (51%), Gaps = 44/755 (5%)

Query: 48  INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI-DIKSIKEVRTGK 106
           + +M+ GS L+K+RS +    R + L  D  S+ ++     +    I  ++ I+ VR G 
Sbjct: 10  VRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGH 69

Query: 107 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 166
            ++  R  G     +     ++ +    ++LDL A +A+ A  WV GL  L    +  LD
Sbjct: 70  QSEGLRRFG--GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL----RARLD 123

Query: 167 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKEL-HK 225
            +  SQ      W+       D +    ++       +R +N  +      L FKE  H 
Sbjct: 124 AM--SQRERLDHWIHSYLHRADSNQDSKMSFKETKSLLRMVNVDMNDMYAYLLFKECDHS 181

Query: 226 SKDK-AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHI 284
           + D+  G E+  EEF+     L  RPE+  +  Q+S     L   +L+ FLE +QG    
Sbjct: 182 NNDRLEGAEI--EEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 235

Query: 285 NEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYF 344
               + ++I  YE ++  ++   +++DGF  YL+SP+    D  H  V QDM QPL+HYF
Sbjct: 236 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 295

Query: 345 INSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVF 404
           I+SSHNTYL + Q  GPS    Y+RA   GCR VELD W+GP  EPVIY GHT+TS+I+F
Sbjct: 296 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 355

Query: 405 RSVIDIINKYAFFASEYPLILCLENHCSIXXXXXXXXXXXXLLGDKLYTT---SPNVEES 461
           R V+  +  +AF  S YP+IL LENHC +            +LGD L T    SPN EE 
Sbjct: 356 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEE- 414

Query: 462 YLPSPDVXXXXXXXXXXXXSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPV---- 517
            LPSP+                  G +      ++G  +S R  +E  ++     V    
Sbjct: 415 -LPSPEQLKGRVL---------VKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAA 464

Query: 518 -KRF--QLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 574
            +R   Q+  ELS L   C + + +    +    +  +V S +E  A K   E    FV 
Sbjct: 465 QRRLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVR 524

Query: 575 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 634
           +N R L RV+P  +R++S+N +PQ+ W  GCQ+VA+NFQTPG  MDLN G F  NG CGY
Sbjct: 525 HNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGY 584

Query: 635 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 694
           VL+PA +R+  S F        PG     L I++++ Q  PK         +VDP V +E
Sbjct: 585 VLKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPH-SIVDPLVRIE 639

Query: 695 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQY 753
           IHG+PADCA Q T  V  NG  P + ++ +FQ+  PELA+VRFVV D D    ++F+GQ+
Sbjct: 640 IHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQF 699

Query: 754 TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 788
           T+P   L+ GYRH+ L S  G  L+ A+LF+ + I
Sbjct: 700 TLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 734






  Database: All non-redundant GenBank CDS
  translations+PDB+SwissProt+PIR+PRF
    Posted date:  Mar 9, 2003  1:51 AM
  Number of letters in database: 813,738,281
  Number of sequences in database:  2,518,611
  
Lambda     K      H
   0.318    0.134    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,639,538,282
Number of Sequences: 2518611
Number of extensions: 68445108
Number of successful extensions: 161909
Number of sequences better than 10.0: 693
Number of HSP's better than 10.0 without gapping: 457
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 159224
Number of HSP's gapped (non-prelim): 1188
length of query: 1063
length of database: 813,738,281
effective HSP length: 138
effective length of query: 925
effective length of database: 466,169,963
effective search space: 431207215775
effective search space used: 431207215775
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 80 (35.4 bits)