PROSITE

ADH 1

>SW:ADHA_H UMAN P0732 7 ALCOHOL� DEHYDROGEN ASE ALPHA� CHAIN (EC

1.1.1.1).

 STAGKVIKCK AAVLWELKKP FSIEEVEVAP PKAHEVRIKM VAVGICGTDD

HVVSGTMVTP

�LPVILGHEAA GIVESVGEGV TTVKPGDKVI PLAIPQCGKC

RICKNPESNY CLKNDVSNPQ

�GTLQDGTSRF TCRRKPIHHF LGISTFSQYT

VVDENAVAKI DAASPLEKVC LIGCGFSTGY

�GSAVNVAKVT PGSTCAVFGL

GGVGLSAIMG CKAAGAARII AVDINKDKFA KAKELGATEC

�INPQDYKKPI

QEVLKEMTDG GVDFSFEVIG RLDTMMASLL CCHEACGTSV IVGVPPDSQN

LSMNPMLLLT GRTWKGAILG GFKSKECVPK LVADFMAKKF SLDALITHVL PFEKINEGFD

 LLHSGKSIRT ILMF

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

���� 300 - 303� NLSM

>PDOC00004 PS00004 CAMP_PHOSPHO_SITE cAMP- and cGMP-dependent protein kinase phosphorylation site [pattern].

���� 338 - 341� KKfS

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

������ 82 - 84� TvK

���� 127 - 129� TsR

���� 131 - 133� TcR

���� 310 - 312� TgR

���� 313 - 315� TwK

���� 364 - 366� SgK

���� 367 - 369� SiR

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

������ 22 - 25� SieE

������ 75 - 78� SvgE

���� 122 - 125� TlqD

���� 150 - 153� TvvD

���� 164 - 167� SplE

>PDOC00007 PS00007 TYR_PHOSPHO_SITE Tyrosine kinase phosphorylation site [pattern].

���� 104 - 110� Knp.Esn.Y

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 44 - 49� GIcgTD

������ 71 - 76� GIveSV

���� 173 - 178� GCgfST

���� 181 - 186� GSavNV

���� 192 - 197� GStcAV

���� 202 - 207� GVglSA

���� 210 - 215� GCkaAG

���� 236 - 241� GAteCI

���� 261 - 266� GVdfSF

���� 316 - 321� GAilGG

���� 320 - 325� GGfkSK

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 66 - 80� GHEaaGivesvGegV

27 hits with 7 PROSITE entries

ADH 2

>SW:ADHB_H UMAN P0032 5 ALCOHOL� DEHYDROGEN ASE BETA C HAIN (EC 1

.1.1.1).

 STAGKVIKCK AAVLWEVKKP FSIEDVEVAP PKAYEVRIKM VAVGICRTDD

HVVSGNLVTP

�LPVILGHEAA GIVESVGEGV TTVKPGDKVI PLFTPQCGKC

RVCKNPESNY CLKNDLGNPR

�GTLQDGTRRF TCRGKPIHHF LGTSTFSQYT

VVDENAVAKI DAASPLEKVC LIGCGFSTGY

�GSAVNVAKVT PGSTCAVFGL

GGVGLSAVMG CKAAGAARII AVDINKDKFA KAKELGATEC

�INPQDYKKPI

QEVLKEMTDG GVDFSFEVIG RLDTMMASLL CCHEACGTSV IVGVPPASQN

LSINPMLLLT GRTWKGAVYG GFKSKEGIPK LVADFMAKKF SLDALITHVL PFEKINEGFD

 LLHSGKSIRT VLTF

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

���� 300 - 303� NLSI

>PDOC00004 PS00004 CAMP_PHOSPHO_SITE cAMP- and cGMP-dependent protein kinase phosphorylation site [pattern].

���� 128 - 131� RRfT

���� 338 - 341� KKfS

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

������ 82 - 84� TvK

���� 127 - 129� TrR

���� 131 - 133� TcR

���� 310 - 312� TgR

���� 313 - 315� TwK

���� 364 - 366� SgK

���� 367 - 369� SiR

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

������ 22 - 25� SieD

������ 75 - 78� SvgE

���� 122 - 125� TlqD

���� 150 - 153� TvvD

���� 164 - 167� SplE

>PDOC00007 PS00007 TYR_PHOSPHO_SITE Tyrosine kinase phosphorylation site [pattern].

���� 104 - 110� Knp.Esn.Y

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 44 - 49� GIcrTD

������ 71 - 76� GIveSV

���� 117 - 122� GNprGT

���� 173 - 178� GCgfST

���� 181 - 186� GSavNV

���� 192 - 197� GStcAV

���� 202 - 207� GVglSA

���� 210 - 215� GCkaAG

���� 236 - 241� GAteCI

���� 261 - 266� GVdfSF

���� 293 - 298� GVppAS

���� 316 - 321� GAvyGG

���� 320 - 325� GGfkSK

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 66 - 80� GHEaaGivesvGegV

30 hits with 7 PROSITE entries

ADH 3

>SW:ADHG_H UMAN P0032 6 ALCOHOL� DEHYDROGEN ASE GAMMA� CHAIN (EC

1.1.1.1).

 STAGKVIKCK AAVLWELKKP FSIEEVEVAP PKAHEVRIKM VAAGICRSDE

HVVSGNLVTP

�LPVILGHEAA GIVESVGEGV TTVKPGDKVI PLFTPQCGKC

RICKNPESNY CLKNDLGNPR

�GTLQDGTRRF TCSGKPIHHF VGVSTFSQYT

VVDENAVAKI DAASPLEKVC LIGCGFSTGY

�GSAVKVAKVT PGSTCAVFGL

GGVGLSVVMG CKAAGAARII AVDINKDKFA KAKELGATEC

�INPQDYKKPI

QEVLKEMTDG GVDFSFEVIG RLDTMMASLL CCHEACGTSV IVGVPPDSQN

LSINPMLLLT GRTWKGAIFG GFKSKESVPK LVADFMAKKF SLDALITNIL PFEKINEGFD

 LLRSGKSIRT VLTF

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

���� 300 - 303� NLSI

>PDOC00004 PS00004 CAMP_PHOSPHO_SITE cAMP- and cGMP-dependent protein kinase phosphorylation site [pattern].

���� 128 - 131� RRfT

���� 338 - 341� KKfS

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

������ 82 - 84� TvK

���� 127 - 129� TrR

���� 133 - 135� SgK

���� 310 - 312� TgR

���� 313 - 315� TwK

���� 364 - 366� SgK

���� 367 - 369� SiR

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

������ 22 - 25� SieE

������ 75 - 78� SvgE

���� 122 - 125� TlqD

���� 150 - 153� TvvD

���� 164 - 167� SplE

>PDOC00007 PS00007 TYR_PHOSPHO_SITE Tyrosine kinase phosphorylation site [pattern].

���� 104 - 110� Knp.Esn.Y

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 44 - 49� GIcrSD

������ 71 - 76� GIveSV

���� 117 - 122� GNprGT

���� 173 - 178� GCgfST

���� 192 - 197� GStcAV

���� 202 - 207� GVglSV

���� 210 - 215� GCkaAG

���� 236 - 241� GAteCI

���� 261 - 266� GVdfSF

���� 316 - 321� GAifGG

���� 320 - 325� GGfkSK

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 66 - 80� GHEaaGivesvGegV

28 hits with 7 PROSITE entries

ADH 4

>SW:ADHP_H UMAN P0831 9 ALCOHOL� DEHYDROGEN ASE CLASS� II PI CHAI

N PRECURSOR (EC 1.1. 1.1).

 GTKGKVIKCK AAIAWEAGKP LCIEEVEVAP

PKAHEVRIQI IATSLCHTDA SVIDSKFEGL

�AFPVIVGHEA AGIVESIGPG

VTNVKPGDKV IPLYAPLCRK CKFCLSPLTN LCGKISNLKS

�PASDQQLMED

KTSRFTCKGK PVYHFFGTST FSQYTVVSDI NLAKIDDDAN LERVCLLGCG

FSTGYGAAIN NAKVTPGSTC AVFGLGGVGL SAVMGCKAAG ASRIIGIDIN SEKFVKAKAL

 GATDCLNPRD LHKPIQEVII ELTKGGVDFA LDCAGGSETM KAALDCTTAG

WGSCTFIGVA

�AGSKGLTIFP EELIIGRTIN GTFFGGWKSV DSIPKLVTDY

KNKKFNLDAL VTHTLPFDKI

�SEAFDLMNQG KSVRTILIFG RCQEQFRILS

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

���� 320 - 323� NGTF

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

���� 132 - 134� TsR

���� 136 - 138� TcK

���� 231 - 233� SeK

���� 279 - 281� TmK

���� 372 - 374� SvR

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

������ 51 - 54� SviD

������ 55 - 58� SkfE

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 72 - 77� GIveSI

���� 178 - 183� GCgfST

���� 186 - 191� GAaiNN

���� 197 - 202� GStcAV

���� 207 - 212� GVglSA

���� 215 - 220� GCkaAG

���� 226 - 231� GIdiNS

���� 241 - 246� GAtdCL

���� 266 - 271� GVdfAL

���� 275 - 280� GGseTM

���� 298 - 303� GVaaGS

�� ��321 - 326� GTffGG

���� 325 - 330� GGwkSV

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 67 - 81� GHEaaGivesiGpgV

22 hits with 5 PROSITE entries

ADH 5

>SW:ADHX_H UMAN P1176 6 ALCOHOL� DEHYDROGEN ASE CLASS� III CHI CH

AIN (EC 1. 1.1.1) (GL UTATHIONE-� DEPENDENT� FORMALDEH YDE DEHYDR

OGENASE) ( EC 1.2.1.1 ) (FDH).

 ANEVIKCKAA VAWEAGKPLS IEEIEVAPPK

AHEVRIKIIA TAVCHTDAYT LSGADPEGCF

�PVILGHEGAG IVESVGEGVT

KLKAGDTVIP LYIPQCGECK FCLNPKTNLC QKIRVTQGKG

�LMPDGTSRFT

CKGKTILHYM GTSTFSEYTV VADISVAKID PLAPLDKVCL LGCGISTGYG

AAVNTAKLEP GSVCAVFGLG GVGLAVIMGC KVAGASRIIG VDINKDKFAR AKEFGATECI

 NPQDFSKPIQ EVLIEMTDGG VDYSFECIGN VKVMRAALEA CHKGWGVSVV

VGVAASGEEI

�ATRPFQLVTG RTWKGTAFGG WKSVESVPKL VSEYMSKKIK

VDEFVTHNLS FDEINKAFEL

�MHSGKSIRTV VKI

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

���� 348 - 351� NLSF

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

���� 126 - 128� TsR

���� 130 - 132� TcK

���� 185 - 187� TaK

���� 309 - 311� TgR

���� 312 - 314� TwK

���� 336 - 338� SkK

���� 363 - 365� SgK

���� 366 - 368� SiR

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

������ 20 - 23� SieE

������ 52 - 55� SgaD

������ 74 - 77� SvgE

���� 144 - 147� TfsE

���� 296 - 299� SgeE

���� 350 - 353� SfdE

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 70 - 75� GIveSV

���� 172 - 177� GCgiST

���� 174 - 179� GIstGY

���� 180 - 185� GAavNT

���� 191 - 196� GSvcAV

���� 201 - 206� GVglAV

���� 209 - 214� GCkvAG

���� 220 - 225� GVdiNK

���� 235 - 240� GAteCI

���� 260 - 265� GVdySF

���� 292 - 297� GVaaSG

���� 315 - 320� GTafGG

���� 319 - 324� GGwkSV

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 65 - 79� GHEgaGivesvGegV

29 hits with 5 PROSITE entries

ADH 6

>SW:ADH6_H UMAN P2833 2 ALCOHOL� DEHYDROGEN ASE 6 (EC� 1.1.1.1).

MSTTGQVIRC KAAILWKPGA PFSIEEVEVA PPKAKEVRIK VVATGLCGTE MKVLGSKHLD

 LLYPTILGHE GAGIVESIGE GVSTVKPGDK VITLFLPQCG ECTSCLNSEG

NFCIQFKQSK

�TQLMSDGTSR FTCKGKSIYH FGNTSTFCEY TVIKEISVAK

IDAVAPLEKV CLISCGFSTG

�FGAAINTAKV TPGSTCAVFG LGGVGLSVVM

GCKAAGAARI IGVDVNKEKF KKAQELGATE

�CLNPQDLKKP IQEVLFDMTD

AGIDFCFEAI GNLDVLAAAL ASCNESYGVC VVVGVLPASV

�QLKISGQLFF

SGRSLKGSVF GGWKSRQHIP KLVADYMAEK LNLDPLITHT LNLDKINEAV

ELMKTGKW

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

���� 143 - 146� NTST

���� 284 - 287� NESY

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

������ 84 - 86� TvK

���� 128 - 130� TsR

���� 132 - 134� TcK

���� 187 - 189� TaK

���� 311 - 313� SgR

���� 314 - 316� SlK

���� 365 - 367� TgK

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

������ 23 - 26� SieE

������ 77 - 80� SigE

���� 146 - 149� TfcE

���� 282 - 285� ScnE

>PDOC00007 PS00007 TYR_PHOSPHO_SITE Tyrosine kinase phosphorylation site [pattern].

������ 57 - 63� Khl.Dll.Y

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 19 - 24� GApfSI

������ 45 - 50� GLcgTE

������ 73 - 78� GIveSI

���� 142 - 147� GNtsTF

���� 182 - 187� GAaiNT

���� 193 - 198� GStcAV

���� 203 - 208� GVglSV

���� 211 - 216� GCkaAG

���� 222 - 227� GVdvNK

���� 237 - 242� GAteCL

���� 262 - 267� GIdfCF

���� 294 - 299� GVlpAS

���� 317 - 322� GSvfGG

���� 321 - 326� GGwkSR

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 68 - 82� GHEgaGivesiGegV

29 hits with 6 PROSITE entries

ADH 7

>SW:ADH7_H UMAN P4039 4 ALCOHOL� DEHYDROGEN ASE CLASS �IV MU/SIGM

A CHAIN (E C 1.1.1.1)� (RETINOL� DEHYDROGEN ASE) (GAST RIC ALCOHO

L DEHYDROG ENASE).

 MGTAGKVIKC KAAVLWEQKQ PFSIEEIEVA PPKTKEVRIK

ILATGICRTD DHVIKGTMVS

�KFPVIVGHEA TGIVESIGEG VTTVKPGDKV

IPLFLPQCRE CNACRNPDGN LCIRSDITGR

�GVLADGTTRF TCKGKPVHHF

MNTSTFTEYT VVDESSVAKI DDAAPPEKVC LIGCGFSTGY

�GAAVKTGKVK

PGSTCVVFGL GGVGLSVIMG CKSAGASRII GIDLNKDKFE KAMAVGATEC

ISPKDSTKPI SEVLSEMTGN NVGYTFEVIG HLETMIDALA SCHMNYGTSV VVGVPPSAKM

 LTYDPMLLFT GRTWKGCVFG GLKSRDDVPK LVTEFLAKKF DLDQLITHVL

PFKKISEGFE

�LLNSGQSIRT VLTF

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

���� 142 - 145� NTST

>PDOC00003 PS00003 SULFATION Tyrosine sulfation site [rule].

���� 142 - 156� ntstfteYtvvdess

>PDOC00004 PS00004 CAMP_PHOSPHO_SITE cAMP- and cGMP-dependent protein kinase phosphorylation site [pattern].

���� 353 - 356� KKiS

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

������ 83 - 85� TvK

���� 118 - 120� TgR

���� 127 - 129� TtR

���� 131 - 133� TcK

���� 186 - 188� TgK

���� 242 - 244� SpK

���� 246 - 248� StK

���� 297 - 299� SaK

���� 310 - 312� TgR

���� 313 - 315� TwK

���� 367 - 369� SiR

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

������ 23 - 26� SieE

������ 76 - 79� SigE

���� 145 - 148� TftE

���� 150 - 153� TvvD

���� 242 - 245� SpkD

���� 274 - 277� TmiD

���� 324 - 327� SrdD

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 45 - 50� GIcrTD

������ 56 - 61� GTmvSK

������ 72 - 77� GIveSI

���� 173 - 178� GCgfST

���� 202 - 207� GVglSV

���� 210 - 215� GCksAG

���� 221 - 226� GIdlNK

���� 236 - 241� GAteCI

���� 259 - 264� GNnvGY

���� 293 - 298� GVppSA

���� 316 - 321� GCvfGG

���� 320 - 325� GGlkSR

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 67 - 81� GHEatGivesiGegV

34 hits with 7 PROSITE entries

SORBITOL DEHYDROGENASE

>SW:DHSO_H UMAN Q0079 6 SORBITOL� DEHYDROGE NASE (EC 1 .1.1.14) (

L-IDITOL 2 -DEHYDROGE NASE).

 AAAAKPNNLS LVVHGPGDLR LENYPIPEPG

PNEVLLRMHS VGICGSDVHY WEYGRIGNFI

�VKKPMVLGHE ASGTVEKVGS

SVKHLKPGDR VAIEPGAPRE NDEFCKMGRY NLSPSIFFCA

�TPPDDGNLCR

FYKHNAAFCY KLPDNVTFEE GALIEPLSVG IHACRRGGVT LGHKVLVCGA

GPIGMVTLLV AKAMGAAQVV VTDLSATRLS KAKEIGADLV LQISKESPQE IARKVEGLLG

 CKPEVTIECT GAEASIQAGI YATRSGGTLV LVGLGSEMTT VPLLHAAIRE

VDIKGVFRYC �����

�NTWPVAISML ASKSVNVKPL VTHRFPLEKA LEAFETFKKG

LGLKIMLKCD PSDQNP

PROSITE Release 17.3, of 12-Feb-2002

>PDOC00001 PS00001 ASN_GLYCOSYLATION N-glycosylation site [pattern].

������� 8 - 11� NLSL

���� 145 - 148� NVTF

>PDOC00005 PS00005 PKC_PHOSPHO_SITE Protein kinase C phosphorylation site [pattern].

������ 81 - 83� SvK

���� 322 - 324� ThR

���� 336 - 338� TfK

>PDOC00006 PS00006 CK2_PHOSPHO_SITE Casein kinase II phosphorylation site [pattern].

���� 121 - 124� TppD

���� 147 - 150� TfeE

���� 227 - 230� SpqE

���� 250 - 253� TgaE

>PDOC00008 PS00008 MYRISTYL N-myristoylation site [pattern].

������ 42 - 47� GIcgSD

���� 160 - 165� GIhaCR

���� 168 - 173� GVtlGH

���� 237 - 242� GLlgCK

���� 251 - 256� GAeaSI

���� 259 - 264� GIyaTR

���� 275 - 280� GSemTT

>PDOC00058 PS00059 ADH_ZINC Zinc-containing alcohol dehydrogenases signature [pattern].

������ 68 - 82� GHEasGtvekvGssV

17 hits with 5 PROSITE entries