Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
RID: 1015865421-9874-12190
Query= CDK2_HUMAN
(298 letters)
Database: Completed Saccharomyces cerevisiae;
6306 sequences; 2,967,424 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Taxonomy reports
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_009718.1| (NC_001134) Catalytic subunit of the main ... 383 e-107
ref|NP_015294.1| (NC_001148) involved in phosphate and glyc... 333 1e-92
ref|NP_010175.1| (NC_001136) serine-threonine kinase, subun... 226 3e-60
ref|NP_012783.1| (NC_001143) putative kinase subunit of the... 215 8e-57
ref|NP_015487.1| (NC_001148) CDC28/cdc2 related protein kin... 207 2e-54
ref|NP_009537.1| (NC_001134) Required for the arrest of cel... 187 1e-48
ref|NP_015283.1| (NC_001148) Component of RNA polymerase II... 185 6e-48
ref|NP_013214.1| (NC_001144) osmoregulation; Hog1p [Sacchar... 178 8e-46
ref|NP_011554.1| (NC_001139) Recovery from alpha factor arr... 176 4e-45
ref|NP_011895.1| (NC_001140) Suppressor of lyt2; Slt2p [Sac... 169 5e-43
ref|NP_015379.1| (NC_001148) involved in sporulation; Smk1p... 165 7e-42
ref|NP_013859.1| (NC_001145) Required for Ime1p phosphoryla... 157 1e-39
ref|NP_014092.1| (NC_001146) Disp. for mitosis, required fo... 154 1e-38
ref|NP_012761.1| (NC_001143) Hypothetical ORF; Ykl161cp [Sa... 152 6e-38
ref|NP_012429.1| (NC_001142) Positive regulator of meiosis,... 144 1e-35
ref|NP_010204.1| (NC_001136) putative protein kinase with s... 136 3e-33
ref|NP_012394.1| (NC_001142) Serine-threonine protein kinas... 134 2e-32
ref|NP_014704.1| (NC_001147) may have a role in regulation ... 128 1e-30
ref|NP_012440.1| (NC_001142) bypass requirement for protein... 128 1e-30
ref|NP_009411.1| (NC_001133) Required for mitosis and sporu... 127 3e-30
ref|NP_014513.1| (NC_001147) Hypothetical ORF; Yol128cp [Sa... 120 3e-28
ref|NP_010795.1| (NC_001136) Growth inhibitory gene; Gin4p ... 118 1e-27
ref|NP_010765.1| (NC_001136) Required for release from gluc... 117 3e-27
ref|NP_009998.2| (NC_001135) functionally redundant with, a... 115 6e-27
ref|NP_012229.1| (NC_001141) alpha subunit of casein kinase... 113 3e-26
ref|NP_015172.1| (NC_001148) Required for DNA damage-induce... 112 5e-26
ref|NP_015175.1| (NC_001148) Hypothetical ORF; Ypl150wp [Sa... 110 3e-25
ref|NP_009907.2| (NC_001135) involved in septin organizatio... 109 5e-25
ref|NP_011336.1| (NC_001139) Hypothetical ORF; Tos3p [Sacch... 108 1e-24
ref|NP_012821.1| (NC_001143) Negative regulator of swe1 kin... 107 3e-24
ref|NP_015115.1| (NC_001148) Regulation of yeast chromosome... 106 4e-24
ref|NP_011856.1| (NC_001140) Involved in pheromone response... 103 2e-23
ref|NP_010811.1| (NC_001136) dispensable for mitosis, invol... 100 3e-22
ref|NP_011970.1| (NC_001140) Kinase that interacts with Cdc... 100 4e-22
ref|NP_013466.1| (NC_001144) involved in the mating signall... 99 6e-22
ref|NP_010182.1| (NC_001136) DNA damage response; Dun1p [Sa... 99 8e-22
ref|NP_014428.1| (NC_001146) Suppressor of Sensor Kinase (S... 97 4e-21
ref|NP_012796.1| (NC_001143) 76.5 kDa Serine/threonine prot... 95 2e-20
ref|NP_014528.1| (NC_001147) Serine/threonine protein kinas... 95 2e-20
ref|NP_009445.1| (NC_001134) Protein Kinase C; Pkc1p [Sacch... 94 2e-20
ref|NP_010754.1| (NC_001136) Hypothetical ORF; Ydr466wp [Sa... 94 3e-20
ref|NP_012075.1| (NC_001140) protein kinase involved in gro... 93 4e-20
ref|NP_015121.1| (NC_001148) Involved in nutrient control o... 93 4e-20
ref|NP_014216.1| (NC_001146) protein kinase homolog; Npr1p ... 93 6e-20
ref|NP_009584.1| (NC_001134) Hypothetical ORF; Ybr028cp [Sa... 92 7e-20
ref|NP_013822.1| (NC_001145) protein kinase; Ypk2p [Sacchar... 92 7e-20
ref|NP_010067.1| (NC_001136) Prr2p [Saccharomyces cerevisiae] 92 1e-19
ref|NP_014910.1| (NC_001147) Hypothetical ORF; Yor267cp [Sa... 92 1e-19
ref|NP_012371.1| (NC_001142) putative catalytic subunit of ... 91 3e-19
ref|NP_012755.1| (NC_001143) Involved in nutrient control o... 90 4e-19
ref|NP_011335.1| (NC_001139) Required for autophagy; Apg1p ... 90 4e-19
ref|NP_010122.1| (NC_001136) Serine/threonine/tyrosine prot... 90 5e-19
ref|NP_015185.1| (NC_001148) Member of MAP kinase pathway i... 90 5e-19
ref|NP_014101.1| (NC_001146) Involved in localizing cell gr... 89 1e-18
ref|NP_013714.1| (NC_001145) CDC5 is dispensable for premei... 89 1e-18
ref|NP_116669.1| (NC_001138) Calmodulin-dependent protein k... 88 1e-18
ref|NP_010407.1| (NC_001136) Serine/threonine protein kinas... 88 2e-18
ref|NP_009833.1| (NC_001134) checkpoint kinase 1; homolog o... 87 3e-18
ref|NP_013197.1| (NC_001144) Serine/threonine protein kinas... 87 3e-18
ref|NP_010256.1| (NC_001136) Required for spindle pole body... 86 5e-18
ref|NP_011055.1| (NC_001137) high copy suppressor of temper... 86 5e-18
ref|NP_014445.1| (NC_001146) Hypothetical ORF; Ynr047wp [Sa... 86 9e-18
ref|NP_010259.1| (NC_001136) Hypothetical ORF; Ydl025cp [Sa... 86 9e-18
ref|NP_011946.1| (NC_001140) Involved in myo-inositol biosy... 86 9e-18
ref|NP_116620.1| (NC_001138) RIM15 is glucose-repressed; RI... 83 5e-17
ref|NP_012407.1| (NC_001142) Involved in osmoregulation, me... 83 5e-17
ref|NP_010015.2| (NC_001135) Putative serine/threonine prot... 82 1e-16
ref|NP_014541.1| (NC_001147) Pkb-activating Kinase Homologu... 81 2e-16
ref|NP_014874.1| (NC_001147) Mitogen-activated kinase-kinas... 81 2e-16
ref|NP_014626.1| (NC_001147) Calmodulin-dependent protein k... 81 2e-16
ref|NP_009410.1| (NC_001133) protein kinase; Kin3p [Sacchar... 80 4e-16
ref|NP_013081.1| (NC_001144) protein kinase homolog; Kns1p ... 80 4e-16
ref|NP_010778.1| (NC_001136) Pkb-activating Kinase Homologu... 80 5e-16
ref|NP_015184.1| (NC_001148) Hypothetical ORF; Ypl141cp [Sa... 80 5e-16
ref|NP_014876.1| (NC_001147) protein kinase; Kin4p [Sacchar... 79 7e-16
ref|NP_011566.1| (NC_001139) Hypothetical ORF; Ygr052wp [Sa... 79 9e-16
ref|NP_009385.1| (NC_001133) contains serine/threonine prot... 78 2e-15
ref|NP_011606.1| (NC_001139) kinase required for late nucle... 77 4e-15
ref|NP_010267.1| (NC_001136) Required for mitotic DNA synth... 77 4e-15
ref|NP_116624.1| (NC_001138) binds and phosphorylates Cdc28... 75 1e-14
ref|NP_012593.1| (NC_001142) Putative serine/threonine prot... 75 2e-14
ref|NP_012370.1| (NC_001142) Protein kinase homolog, mutant... 73 5e-14
ref|NP_010533.1| (NC_001136) Hypothetical ORF; Ydr247wp [Sa... 73 5e-14
ref|NP_015436.1| (NC_001148) kinase required for late nucle... 73 5e-14
ref|NP_009934.1| (NC_001135) Protein with similarity to Npr... 72 1e-13
ref|NP_014996.1| (NC_001147) Disp. for chr. pairing & chr. ... 71 2e-13
ref|NP_012753.1| (NC_001143) Serine/threonine protein kinas... 69 1e-12
ref|NP_014597.1| (NC_001147) Hypothetical ORF; Yol045wp [Sa... 68 2e-12
ref|NP_010569.1| (NC_001136) Derepression of GCN4 expressio... 67 3e-12
ref|NP_014238.1| (NC_001146) cell wall biosynthesis kinase;... 66 6e-12
ref|NP_012348.1| (NC_001142) Protein kinase that inhibits G... 65 1e-11
ref|NP_011357.1| (NC_001139) Serine/threonine protein kinas... 65 1e-11
ref|NP_012723.1| (NC_001143) Putative serine/threonine prot... 62 1e-10
ref|NP_015299.1| (NC_001148) multicopy suppressor of snf3 a... 60 4e-10
ref|NP_014019.1| (NC_001145) Hypothetical ORF; Ymr291wp [Sa... 58 2e-09
ref|NP_013943.1| (NC_001145) SRPK1-like Kinase in Yeast (SR... 57 3e-09
ref|NP_011950.1| (NC_001140) Serine/threonine kinase simila... 57 3e-09
ref|NP_012003.1| (NC_001140) membrane-bound casein kinase I... 53 7e-08
ref|NP_012750.1| (NC_001143) Hypothetical ORF; Ykl171wp [Sa... 49 9e-07
ref|NP_009615.1| (NC_001134) Ark-family kinase-like protein... 48 2e-06
Alignments
>ref|NP_009718.1| (NC_001134) Catalytic subunit of the main cell cycle
cyclin-dependent kinase; Cdc28p [Saccharomyces
cerevisiae]
Length = 298
Score = 383 bits (984), Expect = e-107
Identities = 185/298 (62%), Positives = 235/298 (78%), Gaps = 15/298 (5%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDTETEGVPSTAIREISLLKE 57
+ N++++EK+GEGTYGVVYKA + G+ VVALKKIRL++E EGVPSTAIREISLLKE
Sbjct: 5 LANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKE 64
Query: 58 LNHPNIVKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALTGIP------LPLIKSYLFQ 110
L NIV+L D++H++ +KLYLVFEFL DLK++M+ GIP ++K ++ Q
Sbjct: 65 LKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYME-----GIPKDQPLGADIVKKFMMQ 119
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
L +G+A+CHSHR+LHRDLKPQNLLIN +G +KL DFGLARAFGVP+R YTHE+VTLWYRA
Sbjct: 120 LCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRA 179
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
PE+LLG K YST VD WS+GCIFAEM R+ +F GDSEIDQ+F+IFR LGTP+E +WP +
Sbjct: 180 PEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDI 239
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
+PD+KPSFP+W R+D S+VVP LD G LL ++L YDP RISA+ A HP+FQ+
Sbjct: 240 VYLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQE 297
>ref|NP_015294.1| (NC_001148) involved in phosphate and glycogen metabolism and cell
cycle progression; Pho85p [Saccharomyces cerevisiae]
Length = 305
Score = 333 bits (855), Expect = 1e-92
Identities = 165/294 (56%), Positives = 217/294 (73%), Gaps = 10/294 (3%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
F+++EK+G GTY VYK NK TG VALK+++LD+E EG PSTAIREISL+KEL H NI
Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHENI 65
Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASAL----TGIPLPLIKSYLFQLLQGLAFCH 119
V+L DVIHTENKL LVFEF+ DLKK+MD+ + G+ L L+K + +QLLQGLAFCH
Sbjct: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
+++LHRDLKPQNLLIN G +KL DFGLARAFG+PV T++ EVVTLWYRAP++L+G +
Sbjct: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
YST++DIWS GCI AEM+T + LFPG ++ +QL IF +GTP+E +WP VT +P Y P+
Sbjct: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245
Query: 240 FPKWARQDFSKVV-----PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
+ +D +V+ PLD + L +L +P+ R+SAK AL HP+F +
Sbjct: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299
>ref|NP_010175.1| (NC_001136) serine-threonine kinase, subunit of transcription
factor TFIIK, a subcomplex of TFIIH; Kin28p
[Saccharomyces cerevisiae]
Length = 306
Score = 226 bits (577), Expect = 3e-60
Identities = 117/291 (40%), Positives = 174/291 (59%), Gaps = 3/291 (1%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+ K +K+GEGTY VVY TG +A+K+I+ +G+ +AIRE+ L+E+ HPN+
Sbjct: 7 YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNV 66
Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123
++L+D+ + L LV EFL DL+ + ++ P IK+++ L+G+ CH + +
Sbjct: 67 IELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPAD-IKAWMLMTLRGVYHCHRNFI 125
Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183
LHRDLKP NLL + +G IK+ADFGLARA P T VVT WYRAPE+L G K+Y++A
Sbjct: 126 LHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSA 185
Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK--PSFP 241
+DIWS+G IFAE++ R PG +++DQ+ FR LGTP + WP V+S Y +P
Sbjct: 186 IDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYP 245
Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
+R + K E + ML +P KR +A L +F+++ P
Sbjct: 246 PPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPP 296
>ref|NP_012783.1| (NC_001143) putative kinase subunit of the kinase complex that
phosphorylates the RPO21 CTD (carboxy-terminal domain);
also called CTDK-I alpha subunit; Ctk1p [Saccharomyces
cerevisiae]
Length = 528
Score = 215 bits (547), Expect = 8e-57
Identities = 116/301 (38%), Positives = 175/301 (57%), Gaps = 16/301 (5%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+ ++ ++GEGTYG VYKA+N T ++VALKK+RL E EG P T+IREI LL+ +HPN+
Sbjct: 183 YLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNV 242
Query: 64 VKLLDV-IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
+ ++ + ++ +Y++FE+ DL + + I K QLL G+ + H ++
Sbjct: 243 STIKEIMVESQKTVYMIFEYADNDLSGLL-LNKEVQISHSQCKHLFKQLLLGMEYLHDNK 301
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182
+LHRD+K N+LI+ +G +K+ DFGLAR YT+ V+TLWYR PE+LLG Y T
Sbjct: 302 ILHRDVKGSNILIDNQGNLKITDFGLARKMNSRA-DYTNRVITLWYRPPELLLGTTNYGT 360
Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPK 242
VD+W GC+ E+ + A+F G +E++Q+ IF+ +GTP WP + MP + P
Sbjct: 361 EVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMP- 419
Query: 243 WARQDFSKVVPPLDEDGRSLLS---------QMLHYDPNKRISAKAALAHPFFQDVTKPV 293
Q +K V E +S+L +L YD KR SA AL +F++ KP
Sbjct: 420 ---QQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKEEPKPE 476
Query: 294 P 294
P
Sbjct: 477 P 477
>ref|NP_015487.1| (NC_001148) CDC28/cdc2 related protein kinase; Sgv1p [Saccharomyces
cerevisiae]
Length = 657
Score = 207 bits (527), Expect = 2e-54
Identities = 122/328 (37%), Positives = 185/328 (56%), Gaps = 40/328 (12%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
++++ EK+G+GT+G VYK + T VA+KKI + E + P TA REI++LK LNH N
Sbjct: 59 HYREDEKLGQGTFGEVYKGIHLETQRQVAMKKIIVSVEKDLFPITAQREITILKRLNHKN 118
Query: 63 IVKLLDVIHTEN-------------KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109
I+KL+++++ + Y++ ++ DL + + + + IK+ +
Sbjct: 119 IIKLIEMVYDHSPDITNAASSNLHKSFYMILPYMVADLSGVLHNPRIN-LEMCDIKNMML 177
Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRT---------- 158
Q+L+GL + H + +HRD+K N+LI+ G +KLADFGLAR + G P
Sbjct: 178 QILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYPGGAGSGA 237
Query: 159 -YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217
YT VVT WYRAPE++LG K Y+TAVDIW +GC+FAE ++ + G ++IDQ IF+
Sbjct: 238 KYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEKKPILQGKTDIDQGHVIFK 297
Query: 218 TLGTPDEVVWPGVTSMP-------DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYD 270
LGTP E W +P +YKP+ R+ F K L E G L Q+L D
Sbjct: 298 LLGTPTEEDWAVARYLPGAELTTTNYKPTL----RERFGKY---LSETGLDFLGQLLALD 350
Query: 271 PNKRISAKAALAHPFFQDVTKPVPHLRL 298
P KR++A +A HP+F++ P + L
Sbjct: 351 PYKRLTAMSAKHHPWFKEDPLPSEKITL 378
>ref|NP_009537.1| (NC_001134) Required for the arrest of cells in G(sub)1 in response
to pheromone and cell fusion during conjugation; Fus3p
[Saccharomyces cerevisiae]
Length = 353
Score = 187 bits (476), Expect = 1e-48
Identities = 114/308 (37%), Positives = 161/308 (52%), Gaps = 22/308 (7%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
+FQ +GEG YGVV A +K TGE+VA+KKI + T +REI +LK H N
Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRT-LREIKILKHFKHEN 70
Query: 63 IVKLLDVIHTE-----NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
I+ + ++ + N++Y++ E + DL + + L+ I+ +++Q L+ +
Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSD---DHIQYFIYQTLRAVKV 127
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----------YTHEVVTLW 167
H V+HRDLKP NLLIN+ +K+ DFGLAR T V T W
Sbjct: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187
Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227
YRAPE++L YS A+D+WS GCI AE+ RR +FPG QL IF +GTP
Sbjct: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDND 247
Query: 228 PGVTSMP---DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284
P +Y S P + K+ P ++ G LL +ML +DP KRI+AK AL HP
Sbjct: 248 LRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP 307
Query: 285 FFQDVTKP 292
+ Q P
Sbjct: 308 YLQTYHDP 315
>ref|NP_015283.1| (NC_001148) Component of RNA polymerase II holoenzyme, involved in
RNA pol II carboxy-terminal domain phosphorylation.
Activity of the kinase (SSN3)/cyclin (SSN8) pair
required, along with SSN6 & TUP1, for transcriptional
repression of a-specific genes>
Length = 555
Score = 185 bits (470), Expect = 6e-48
Identities = 101/272 (37%), Positives = 163/272 (59%), Gaps = 21/272 (7%)
Query: 43 GVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKK---FMDASALTGI 99
G+ +A RE++L +EL++ ++ L+++ +++V+E+ DL + F I
Sbjct: 199 GISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMI 258
Query: 100 PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT- 158
P +++S ++QLL G+++ H + VLHRDLKP N+++ +G +K+ D GLAR F ++T
Sbjct: 259 PPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTL 318
Query: 159 YTHE--VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS--------- 207
YT + VVT+WYRAPE+LLG ++Y+ AVD+WS+GCIFAE++ + +F G+
Sbjct: 319 YTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTV 378
Query: 208 --EIDQLFRIFRTLGTPDEVVWPGVTSMPDYK--PSFPKWARQ--DFSKVVPPLDEDGRS 261
+++QL RI LGTPD+ +WP + P+Y FPK+ + D+ S
Sbjct: 379 PFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALS 438
Query: 262 LLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
LL +L+YDP KRI A AL H +F + PV
Sbjct: 439 LLYHLLNYDPIKRIDAFNALEHKYFTESDIPV 470
Score = 27.3 bits (59), Expect = 2.9
Identities = 10/25 (40%), Positives = 17/25 (68%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKL 25
+E ++ + I GTYG VYKA+ ++
Sbjct: 72 LEKYEVIGYIAAGTYGKVYKAKRQI 96
>ref|NP_013214.1| (NC_001144) osmoregulation; Hog1p [Saccharomyces cerevisiae]
Length = 435
Score = 178 bits (452), Expect = 8e-46
Identities = 109/285 (38%), Positives = 154/285 (53%), Gaps = 9/285 (3%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+ + +G G +G+V A + LT + VA+KKI T + RE+ LLK L H N+
Sbjct: 23 YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENL 82
Query: 64 VKLLDVIHTE-NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
+ L D+ + +Y V E DL + + L ++ +L+Q+L+GL + HS
Sbjct: 83 ICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEK---QFVQYFLYQILRGLKYVHSAG 139
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182
V+HRDLKP N+LIN +K+ DFGLAR + Y V T +YRAPEI+L + Y
Sbjct: 140 VIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGY---VSTRYYRAPEIMLTWQKYDV 196
Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK--PSF 240
VDIWS GCIFAEM+ + LFPG + Q I LG+P + V + S K S
Sbjct: 197 EVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSL 256
Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
P FS+ ++ D LL +ML +DP KRI+A ALAHP+
Sbjct: 257 PHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPY 301
>ref|NP_011554.1| (NC_001139) Recovery from alpha factor arrest; Kss1p [Saccharomyces
cerevisiae]
Length = 368
Score = 176 bits (446), Expect = 4e-45
Identities = 118/308 (38%), Positives = 171/308 (55%), Gaps = 34/308 (11%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPN 62
++ V+ IGEG YG V A +K +G VA+KKI+ ++ V T IREI LL+ + H N
Sbjct: 13 YKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRT-IREIKLLRYFHEHEN 71
Query: 63 IVKLLDVIHTE-----NKLYLVFEFLHQDLKKFMDA--SALTGIPLPLIKSYLFQLLQGL 115
I+ +LD + N +YLV E + DL+K ++ S + + ++ + +Q+L+ L
Sbjct: 72 IISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRAL 131
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-------VRTYTHEVVTLWY 168
HS +V+HRD+KP NLL+N+ +K+ DFGLAR V T V T WY
Sbjct: 132 KSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWY 191
Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228
RAPEI+L + Y+TA+DIWS GCI AEMV+ + LFPG QL+ I LGTP +
Sbjct: 192 RAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFN 251
Query: 229 GVTS--MPDYKPSFPK---------WARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277
+ S +Y + P W++ D L+ D LL +ML ++P+KRISA
Sbjct: 252 QIKSKRAKEYIANLPMRPPLPWETVWSKTD-------LNPDMIDLLDKMLQFNPDKRISA 304
Query: 278 KAALAHPF 285
AL HP+
Sbjct: 305 AEALRHPY 312
>ref|NP_011895.1| (NC_001140) Suppressor of lyt2; Slt2p [Saccharomyces cerevisiae]
Length = 484
Score = 169 bits (428), Expect = 5e-43
Identities = 113/301 (37%), Positives = 163/301 (53%), Gaps = 21/301 (6%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGE--VVALKKIRLDTETEGVPSTAIREISLLKELN 59
+ FQ +++IG G YG+V AR E VA+KK+ + ++RE+ LL+
Sbjct: 21 KRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFR 80
Query: 60 -HPNIVKLLD---VIHTE---NKLYLVFEFLHQDLKKFMDASALTGIPLP--LIKSYLFQ 110
H NI L D V + + N LYL E + D+ + + + G PL +S+ +Q
Sbjct: 81 GHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKS----GQPLTDAHYQSFTYQ 136
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV-PVRT---YTHEVVTL 166
+L GL + HS VLHRDLKP NLL+N + +K+ DFGLAR + PV T V T
Sbjct: 137 ILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATR 196
Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT-PDEV 225
WYRAPEI+L + Y+ A+D+WS GCI AE + + +F G ++QL +I + LGT PDE
Sbjct: 197 WYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPDET 256
Query: 226 VWP-GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284
+ G ++ DY + F + P + LL QML +DP KRI+ AL HP
Sbjct: 257 LRRIGSKNVQDYIHQLGFIPKVPFVNLYPNANSQALDLLEQMLAFDPQKRITVDEALEHP 316
Query: 285 F 285
+
Sbjct: 317 Y 317
>ref|NP_015379.1| (NC_001148) involved in sporulation; Smk1p [Saccharomyces
cerevisiae]
Length = 388
Score = 165 bits (418), Expect = 7e-42
Identities = 105/308 (34%), Positives = 167/308 (54%), Gaps = 21/308 (6%)
Query: 4 FQKVEKIGEGTYGVV--YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-H 60
++ ++ +G+G YG V K + + +A+KKI E + AIRE+ + H
Sbjct: 38 YEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGH 97
Query: 61 PNIVKLLDV-IHTENK---LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116
NIV L+D+ I T + LY E + DL K + +S + IK +L+Q+L GL
Sbjct: 98 KNIVNLIDLEIVTSSPYDGLYCYQELIDYDLAKVIHSSVQ--LSEFHIKYFLYQILCGLK 155
Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV-------PVRTY-THEVVTLWY 168
+ HS V+HRDLKP N+L G +K+ DFGLAR V+ + T+ V T WY
Sbjct: 156 YIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWY 215
Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228
RAPE+LL + YS +VDIW++GCI AE R+ +F G + Q+F I + LGTPD+ +
Sbjct: 216 RAPELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILI 275
Query: 229 GVTSMPDY----KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284
++ + + P + + +S + P + +L+ +LH+D R++ + A++HP
Sbjct: 276 KFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHP 335
Query: 285 FFQDVTKP 292
F +V KP
Sbjct: 336 FLNEVRKP 343
>ref|NP_013859.1| (NC_001145) Required for Ime1p phosphorylation, association of the
Ime1p-Ume6p meiotic activator, early meiotic gene
expression, and sporulation; Rim11p [Saccharomyces
cerevisiae]
Length = 370
Score = 157 bits (398), Expect = 1e-39
Identities = 101/298 (33%), Positives = 164/298 (54%), Gaps = 21/298 (7%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
+F E +G G++GVV+ + T E VA+KK+ D + RE+ ++K L+H N
Sbjct: 38 SFPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKN------RELEIMKMLSHIN 91
Query: 63 IVKLLDVIH---TENKLYL--VFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQGL 115
I+ L + +++++YL + E++ Q L + + P+ IK Y+FQL + L
Sbjct: 92 IIDLKYFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSL 151
Query: 116 AFCHSH-RVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173
+ H V HRD+KPQNLL++ E ++KL DFG A+ P + + +YRAPE+
Sbjct: 152 NYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLK-PTEPNVSYICSRYYRAPEL 210
Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233
+ G Y+ +DIWS GC+ AE++ + +FPG+S IDQL I + LGTP + + SM
Sbjct: 211 IFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSK---QEICSM 267
Query: 234 -PDY-KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
P+Y + FP+ S+V D+ L+ +L YDP +R +A L P+F ++
Sbjct: 268 NPNYMEHKFPQIKPIPLSRVFKKEDDQTVEFLADVLKYDPLERFNALQCLCSPYFDEL 325
>ref|NP_014092.1| (NC_001146) Disp. for mitosis, required for chr. segregation,
benomyl resist., basal IME1 transcript. in mitosis, IME1
induction in meiosis & ascus mat. independ. of IME1;
maybe in mitotic chr. segregation specific to CDEIII;
Mck1p [Saccharomyces cerev>
Length = 375
Score = 154 bits (390), Expect = 1e-38
Identities = 104/307 (33%), Positives = 164/307 (52%), Gaps = 34/307 (11%)
Query: 5 QKVEKIGEGTYGVVYKA-----RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59
++ KIG G +G V +A + G A+KK+ TE + RE+ +L+ +
Sbjct: 36 KEYRKIGRGAFGTVVQAYLTQDKKNWLGPF-AIKKVPAHTEYKS------RELQILRIAD 88
Query: 60 HPNIVKL----LDVIHTENKLY--LVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQL 111
HPNIVKL + +NK+Y L E L + L+ ++ + +PL I+ Y +Q+
Sbjct: 89 HPNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQI 148
Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAF--GVPVRTYTHEVVTLWY 168
+G+ + H V HRD+KP N+L++ E G +K+ DFG A+ P +Y + + +Y
Sbjct: 149 ARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISY---ICSRFY 205
Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228
RAPE+++GC Y+T +DIW LGC+ EM+ +A+F G + QL I + LG PD+
Sbjct: 206 RAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFI- 264
Query: 229 GVTSMPDY------KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282
S P Y KP F ++Q F K DG LL ++L Y+P +R+S + LA
Sbjct: 265 -FFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILA 323
Query: 283 HPFFQDV 289
H FF ++
Sbjct: 324 HQFFNEL 330
>ref|NP_012761.1| (NC_001143) Hypothetical ORF; Ykl161cp [Saccharomyces cerevisiae]
Length = 433
Score = 152 bits (384), Expect = 6e-38
Identities = 98/299 (32%), Positives = 160/299 (52%), Gaps = 17/299 (5%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEV--VALKKIRLDTETEGVPSTAIREISLLKELN 59
++F KIG G++ ++ + + E VA++KI + +RE+ LL+ L
Sbjct: 21 KHFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLR 80
Query: 60 -HPNIVKLLD---VIHTE---NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
HPNIV L D V + N +YL E + DL + + + + +S+++Q+L
Sbjct: 81 GHPNIVWLFDTDIVFYPNGALNGVYLYEELMECDLSQIIRSEQR--LEDAHFQSFIYQIL 138
Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----YTHEVVTLWY 168
L + HS VLH DLKP+NLL+N++ +K+ +FGL+ ++ + + ++WY
Sbjct: 139 CALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLSCSYSENHKVNDGFIKGYITSIWY 198
Query: 169 RAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228
+APEILL + + AVDIWS GCI AE++ R+ +F G +D L I + LGTP E
Sbjct: 199 KAPEILLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEETLQ 258
Query: 229 GVTSMP--DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
+ S +Y F + F ++P + + LL +ML +DP KRI+ + AL HP+
Sbjct: 259 EIASQKVYNYIFQFGNIPGRSFESILPGANPEALELLKKMLEFDPKKRITVEDALEHPY 317
>ref|NP_012429.1| (NC_001142) Positive regulator of meiosis, dispensable for mitosis,
stimulates early, middle and late gene expression and
negatively regulates IME1; Ime2p [Saccharomyces
cerevisiae]
Length = 645
Score = 144 bits (364), Expect = 1e-35
Identities = 112/360 (31%), Positives = 172/360 (47%), Gaps = 80/360 (22%)
Query: 2 ENFQKVEKIGEGTYGVVYKAR-----NKLTGEVVALKKIRLD----------TETEGVPS 46
+ +Q +EK+G G++G V A+ + + G+ ++ +D T+T+GV +
Sbjct: 36 DRYQLIEKLGAGSFGCVTLAKAQFPLSNILGKQHDIRGTLMDQPKNGHQNYITKTQGVVA 95
Query: 47 --------------TAIREISLLKELN-HPNIVKLLDV-IHTEN-KLYLVFEFLHQDLKK 89
T +REI + + + +++++ +V I +EN +L++V E + Q+L +
Sbjct: 96 IKTMMTKLHTLQDYTRVREIKFILAIPANDHLIQIFEVFIDSENYQLHIVMECMEQNLYQ 155
Query: 90 FMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG---------- 139
M +P +KS L Q+L GL H H HRDLKP+N+LI
Sbjct: 156 MMKHRRRRVFSIPSLKSILSQILAGLKHIHEHNFFHRDLKPENILITPSTQYFEKEYMNQ 215
Query: 140 -------AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCI 192
IKLADFGLAR YT V T WYR+PEILL YYS +DIW+ GC+
Sbjct: 216 IGYQDNYVIKLADFGLARHVENK-NPYTAYVSTRWYRSPEILLRSGYYSKPLDIWAFGCV 274
Query: 193 FAEMVTRRALFPGDSEIDQLFRIFRTLGTP----DEVVWPGVTSMPDYKPSFPKWARQDF 248
E+ RALFPG +EIDQ+++I LGTP D V +T+ P P D
Sbjct: 275 AVEVTVFRALFPGANEIDQIWKILEVLGTPIKRSDFVNTNHITAPP------PGGFWDDA 328
Query: 249 SKVVPPLD--------------------EDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
S +V L+ D ++ + L +DPN+R +A+ PFF++
Sbjct: 329 SNLVHKLNLKLPYVEGSSLDHLLSSSQLSDLSEVVKKCLRWDPNERATAQELCEMPFFEN 388
>ref|NP_010204.1| (NC_001136) putative protein kinase with similarity to mammalian
glycogen synthase kinase-3 and Drosophila
Zeste-White3/Shaggy; Mrk1p [Saccharomyces cerevisiae]
Length = 501
Score = 136 bits (343), Expect = 3e-33
Identities = 94/301 (31%), Positives = 155/301 (51%), Gaps = 23/301 (7%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
++ E +G G++GVV T + VA+KK+ D + RE+ +K L HPN
Sbjct: 163 SYPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKN------RELETMKMLCHPN 216
Query: 63 IVKLLDVIHTENK-----LYLVFEF----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQ 113
V L + +++ L LV ++ L+Q L+ F++ +P IK Y +QL +
Sbjct: 217 TVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQ--MPRVEIKFYAYQLFK 274
Query: 114 GLAFCHS-HRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171
L + H+ R+ HRD+KPQNLL++ T + K+ DFG A+ P + + + +YRAP
Sbjct: 275 ALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLK-PDQPNVSYICSRYYRAP 333
Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231
E++ G YS VD+WS C+ AE++ + LF G+S IDQL I + +G P + G+
Sbjct: 334 ELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMN 393
Query: 232 SMPDYKPS-FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290
P+Y+ FP +++ D D LL++ L Y P +R+ L +F +
Sbjct: 394 --PNYEDHVFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSYFDETK 451
Query: 291 K 291
+
Sbjct: 452 R 452
>ref|NP_012394.1| (NC_001142) Serine-threonine protein kinase; Yak1p [Saccharomyces
cerevisiae]
Length = 807
Score = 134 bits (337), Expect = 2e-32
Identities = 80/219 (36%), Positives = 128/219 (57%), Gaps = 10/219 (4%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTE--TEGVPSTAIREI--SLLKELNHPNIVK 65
+G+GT+G V K +N LT E++A+K ++ TE T+ + I E+ + N + ++
Sbjct: 375 LGQGTFGQVVKCQNLLTKEILAVKVVKSRTEYLTQSITEAKILELLNQKIDPTNKHHFLR 434
Query: 66 LLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125
+ D +N L LVFE L +L + + + G+ + LI+++ Q+L L +++H
Sbjct: 435 MYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDSLCVLKESKLIH 494
Query: 126 RDLKPQNLLINT--EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183
DLKP+N+L+ + +K+ DFG + V TY + + +YRAPEI+LG Y ST+
Sbjct: 495 CDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTY---IQSRFYRAPEIILGIPY-STS 550
Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222
+D+WSLGCI AE+ +FPG SE +QL RI TLG P
Sbjct: 551 IDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYP 589
>ref|NP_014704.1| (NC_001147) may have a role in regulation and/or execution of the
eukaryotic cell cycle; Cka2p [Saccharomyces cerevisiae]
Length = 339
Score = 128 bits (321), Expect = 1e-30
Identities = 94/306 (30%), Positives = 157/306 (50%), Gaps = 36/306 (11%)
Query: 1 MENFQKVEKIGEGTYGVVYKAR---NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKE 57
+ N++ + KIG G Y V+ R N + LK +++ RE+ +L
Sbjct: 47 ISNYEIINKIGRGKYSEVFSGRCIVNNQKCVIKVLKPVKM--------KKIYRELKILTN 98
Query: 58 LNH-PNIVKLLDVIH-TENKL-YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
L PN+V L D++ ++K+ L+FE ++K + LP I+ Y QLL
Sbjct: 99 LTGGPNVVGLYDIVQDADSKIPALIFE----EIKNVDFRTLYPTFKLPDIQYYFTQLLIA 154
Query: 115 LAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173
L +CHS ++HRD+KPQN++I+ TE ++L D+GLA F P Y V + +++ PE+
Sbjct: 155 LDYCHSMGIMHRDVKPQNVMIDPTERKLRLIDWGLAE-FYHPGVDYNVRVASRYHKGPEL 213
Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGV-- 230
L+ Y ++D+WS+GC+ A +V ++ F G S DQL +I LGT + + + G
Sbjct: 214 LVNLNQYDYSLDLWSVGCMLAAIVFKKEPFFKGSSNPDQLVKIATVLGTKELLGYLGKYG 273
Query: 231 --------TSMPDY-KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281
M D+ K S+ + + VP + + L+ +L YD +R++AK A+
Sbjct: 274 LHLPSEYDNIMRDFTKKSWTHFITSETKLAVPEVVD----LIDNLLRYDHQERLTAKEAM 329
Query: 282 AHPFFQ 287
H FF+
Sbjct: 330 DHKFFK 335
>ref|NP_012440.1| (NC_001142) bypass requirement for protein kinase C homolog; Bck1p
[Saccharomyces cerevisiae]
Length = 1478
Score = 128 bits (321), Expect = 1e-30
Identities = 94/298 (31%), Positives = 155/298 (51%), Gaps = 49/298 (16%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL---DTETEGVPST--AIR-EISLLKE 57
+ K E IG+G++G VY N TGE++A+K++ + ++ E + ST A+R E+S LK+
Sbjct: 1175 WMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKD 1234
Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPL------PLIKSYLFQL 111
L+H NIV+ L +N +Y +F L+ S + I + PLIK Q+
Sbjct: 1235 LDHLNIVQYLG-FENKNNIYSLF------LEYVAGGSVGSLIRMYGRFDEPLIKHLTTQV 1287
Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTL----W 167
L+GLA+ HS +LHRD+K NLL++ +G K++DFG++R Y++ +T+ +
Sbjct: 1288 LKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRK---SKDIYSNSDMTMRGTVF 1344
Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227
+ APE++ + YS VDIWSLGCI EM + + + +F+I ++ P
Sbjct: 1345 WMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAP----- 1399
Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
+P+ +P + + GR+ L +P KR +A L+HPF
Sbjct: 1400 ----PIPE--------------DTLPLISQIGRNFLDACFEINPEKRPTANELLSHPF 1439
>ref|NP_009411.1| (NC_001133) Required for mitosis and sporulation, cell division
cycle blocked at 36 degrees; Cdc15p [Saccharomyces
cerevisiae]
Length = 974
Score = 127 bits (318), Expect = 3e-30
Identities = 77/190 (40%), Positives = 111/190 (57%), Gaps = 6/190 (3%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
IG G+YGVVYKA NK T +VVA+K++ + + E + + EISLLK LNH NIVK
Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEE--LNDIMAEISLLKNLNHNNIVKYHGF 88
Query: 70 IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129
I +LY++ E+ + + + + TG+ K+Y+ Q L GL + H V+HRD+K
Sbjct: 89 IRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIK 148
Query: 130 PQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189
N+L++ + +KLADFG++ T TL + APEI LG + ST DIWSL
Sbjct: 149 AANILLSADNTVKLADFGVSTIVNSSALTLAG---TLNWMAPEI-LGNRGASTLSDIWSL 204
Query: 190 GCIFAEMVTR 199
G EM+T+
Sbjct: 205 GATVVEMLTK 214
>ref|NP_014513.1| (NC_001147) Hypothetical ORF; Yol128cp [Saccharomyces cerevisiae]
Length = 375
Score = 120 bits (300), Expect = 3e-28
Identities = 92/300 (30%), Positives = 146/300 (48%), Gaps = 36/300 (12%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVV------ALKKIRLDTETEGVPSTAIREISLLKELNHP 61
++IG G++G V ++ L+ + A+K++ + + + E+ +L+ + HP
Sbjct: 45 KRIGHGSFGTV--TQSILSSNSIEWLGPYAIKRVVKSPKVQSL------ELEILQNIRHP 96
Query: 62 NIVKL----------LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLF 109
N+V L D H K + V E++ Q L + G +P IK Y F
Sbjct: 97 NLVTLEFFFESHCTTKDGGHLYQKNF-VMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTF 155
Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLI-NTEGAIKLADFGLARAF--GVPVRTYTHEVVTL 166
Q+L+ L HS + H DLKP N+LI + G K+ DFG A+ ++TY +
Sbjct: 156 QILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTY---FCSR 212
Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVV 226
+YRAPE+LL K Y+T +DIWSLGCI EM+ + LF GDS QL I + LG +
Sbjct: 213 FYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPK-- 270
Query: 227 WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
+ + + + S + F P ++ L ++L YD +R A+ +AH FF
Sbjct: 271 -SSIKNSQELQDSLNDQKFKKFMHWFPSIEFFDVEFLLKVLTYDATERCDARQLMAHEFF 329
>ref|NP_010795.1| (NC_001136) Growth inhibitory gene; Gin4p [Saccharomyces
cerevisiae]
Length = 1142
Score = 118 bits (296), Expect = 1e-27
Identities = 94/297 (31%), Positives = 140/297 (46%), Gaps = 46/297 (15%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRL---------------DTETEGVPSTAIREI 52
E +G G+ G V ARN TG+ A+K I T + +P REI
Sbjct: 23 ETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREI 82
Query: 53 SLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF--Q 110
++K LNHPN+++L DV T LYLV E+ + + + G PLP ++ F Q
Sbjct: 83 IIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKG--ELFNLLVERG-PLPEHEAIRFFRQ 139
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
++ G+++CH+ ++HRDLKP+NLL++ + IK+ADFG+A A + + Y A
Sbjct: 140 IIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMA-ALETEGKLLETSCGSPHYAA 198
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
PEI+ G Y A D+WS G I ++T R P D E + RTL V G
Sbjct: 199 PEIVSGIPYQGFASDVWSCGVILFALLTGR--LPFDEEDGNI----RTLLLK---VQKGE 249
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
MP + + + L+ ++L DP +RI + L HP Q
Sbjct: 250 FEMPSDDE----------------ISREAQDLIRKILTVDPERRIKTRDILKHPLLQ 290
>ref|NP_010765.1| (NC_001136) Required for release from glucose repression, invertase
expression and sporulation; Snf1p [Saccharomyces
cerevisiae]
Length = 633
Score = 117 bits (292), Expect = 3e-27
Identities = 75/215 (34%), Positives = 120/215 (54%), Gaps = 9/215 (4%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI-REISLLKELNHP 61
N+Q V+ +GEG++G V A + TG+ VALK I + I REIS L+ L HP
Sbjct: 54 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 113
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
+I+KL DVI +++++ +V E+ +L ++ + + + Q++ + +CH H
Sbjct: 114 HIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQR--DKMSEQEARRFFQQIISAVEYCHRH 171
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKY 179
+++HRDLKP+NLL++ +K+ADFGL+ G ++T + Y APE++ G Y
Sbjct: 172 KIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKT---SCGSPNYAAPEVISGKLY 228
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214
VD+WS G I M+ RR F D I LF+
Sbjct: 229 AGPEVDVWSCGVILYVMLCRRLPF-DDESIPVLFK 262
>ref|NP_009998.2| (NC_001135) functionally redundant with, and homologous to, SSK2;
Ssk22p [Saccharomyces cerevisiae]
Length = 1331
Score = 115 bits (289), Expect = 6e-27
Identities = 78/218 (35%), Positives = 116/218 (52%), Gaps = 23/218 (10%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIRE-ISLLKELNHP 61
+QK IG GT+G VY A N GE++A+K+I++ DT T I+E +++L+ LNHP
Sbjct: 1034 WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHP 1093
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV+ V +K+ + E+ L +D + + + Y F+LL+GLA+ H
Sbjct: 1094 NIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQV--YTFELLEGLAYLHQ 1151
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARA----------------FGVPVRTYTHEVV 164
V+HRD+KP+N+L++ G IK DFG AR FGV ++ +
Sbjct: 1152 SGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMG 1211
Query: 165 TLWYRAPEILLG--CKYYSTAVDIWSLGCIFAEMVTRR 200
T Y APE + G K A D+W+LGC+ EM T R
Sbjct: 1212 TPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGR 1249
>ref|NP_012229.1| (NC_001141) alpha subunit of casein kinase II; Cka1p [Saccharomyces
cerevisiae]
Length = 372
Score = 113 bits (283), Expect = 3e-26
Identities = 99/343 (28%), Positives = 165/343 (47%), Gaps = 61/343 (17%)
Query: 2 ENFQKVEKIGEGTYGVVY---KARNKLTGEVVALK-----------KIRLDTETEGVPST 47
++++ K+G G Y V+ K +K+ + LK KI D E VP T
Sbjct: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97
Query: 48 AI----------REISLLKELN----------HPNIVKLLDVIHT--ENKLYLVFEFLHQ 85
+ ++ +LK + H NI+ L D+I LVFE++
Sbjct: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157
Query: 86 DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG-AIKLA 144
+ + LT + I+ Y+F+LL+ L +CHS ++HRD+KP N++I+ + ++L
Sbjct: 158 VDFRILYPK-LTDLE---IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213
Query: 145 DFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR-ALF 203
D+GLA + V + Y V + +++ PE+L+ + Y ++D+WS G + A M+ +R F
Sbjct: 214 DWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272
Query: 204 PGDSEIDQLFRIFRTLGTPD--------EVVWP-GVTSMPDY--KPSFPKWAR--QDFSK 250
G S DQL +I + LGT D E+ P M Y KP W R D +K
Sbjct: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP----WHRFINDGNK 328
Query: 251 VVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
+ DE L+ +L YD +R++AK A+ HP+F + + +
Sbjct: 329 HLSGNDEI-IDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370
>ref|NP_015172.1| (NC_001148) Required for DNA damage-induced checkpoint arest in G1,
S/M, and G2/M in mitosis, dispensable for sporulation
but required for wild-type spore viability; Mec1p and
Tel1p regulate rad53p phosphorylation; Rad53p
[Saccharomyces cerevisiae]
Length = 821
Score = 112 bits (281), Expect = 5e-26
Identities = 89/297 (29%), Positives = 141/297 (46%), Gaps = 48/297 (16%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67
E +G+G + V KA + TG+ A+K I + G RE+ +L++LNHP IV+L
Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIIS-KRKVIGNMDGVTRELEVLQKLNHPRIVRLK 260
Query: 68 DVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126
Y+V EF+ DL F+ A G + Q+L + + HS + HR
Sbjct: 261 GFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG--REISRQILTAIKYIHSMGISHR 318
Query: 127 DLKPQNLLINTEG--AIKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEILLG------ 176
DLKP N+LI + +K+ DFGLA+ G ++T+ TL Y APE++ G
Sbjct: 319 DLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCG---TLAYVAPEVIRGKDTSVS 375
Query: 177 ------CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
YS+ VD+WS+GC+ ++T F G ++ DQL ++ +G
Sbjct: 376 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQL---YKQIG---------- 421
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
+ S+ + +DF + E+ R + +L DPN R +A AL HP+ +
Sbjct: 422 ------RGSYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 467
>ref|NP_015175.1| (NC_001148) Hypothetical ORF; Ypl150wp [Saccharomyces cerevisiae]
Length = 901
Score = 110 bits (275), Expect = 3e-25
Identities = 89/288 (30%), Positives = 136/288 (46%), Gaps = 42/288 (14%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
N++ +++IGEG++G VY A ++ T V LK T + P+ +RE+ ++ + P
Sbjct: 40 NYKILKQIGEGSFGKVYLALHRPTHRKVCLK-----TSDKNDPNI-VREVFYHRQFDFPY 93
Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMD-ASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
I KL +VI TE+K+++ E+ K+ D +L I L Q+ + + HS
Sbjct: 94 ITKLYEVIVTESKVWMALEYCPG--KELYDHLLSLRRISLLECGELFAQISGAVYYAHSM 151
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV--TLWYRAPEILLGCKY 179
+HRDLK +N+L++ G KL DFG R + T E V T Y APE++ Y
Sbjct: 152 HCVHRDLKLENILLDKNGNAKLTDFGFTREC---MTKTTLETVCGTTVYMAPELIERRTY 208
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
+DIWSLG I ++T F D E + W V P Y
Sbjct: 209 DGFKIDIWSLGVILYTLITGYLPFDDDDEA--------------KTKWKIVNEEPKYD-- 252
Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
+KV+P +D R L+S++L +P +R S L HPF Q
Sbjct: 253 ---------AKVIP---DDARDLISRLLAKNPGERPSLSQVLRHPFLQ 288
>ref|NP_009907.2| (NC_001135) involved in septin organization; Kcc4p [Saccharomyces
cerevisiae]
Length = 1037
Score = 109 bits (273), Expect = 5e-25
Identities = 86/291 (29%), Positives = 137/291 (46%), Gaps = 40/291 (13%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLD---------TETEGVPSTAIREISLLKEL 58
E +G G+ G V A+++ TG A+K I + +P REI ++K L
Sbjct: 25 ETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLL 84
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSY--LFQLLQGLA 116
+HPN++ L DV T N LYL+ E+ + + + G PLP ++ Q++ G++
Sbjct: 85 SHPNVLSLYDVWETNNNLYLILEYAEKG--ELFNLLVDHG-PLPEREAINCFRQIIIGIS 141
Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
+CH+ ++HRDLKP+NLL+++ IK+ADFG+A A + Y APEI+ G
Sbjct: 142 YCHALGIVHRDLKPENLLLDSFYNIKIADFGMA-ALQTDADLLETSCGSPHYAAPEIVSG 200
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
Y A D+WS G I ++T R P D E + + V G MP+
Sbjct: 201 LPYEGFASDVWSCGVILFALLTGR--LPFDEENGNVRDLLLK-------VQKGQFEMPN- 250
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
+ D + L+ ++L DP +RI + L+HP +
Sbjct: 251 ---------------DTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLK 286
>ref|NP_011336.1| (NC_001139) Hypothetical ORF; Tos3p [Saccharomyces cerevisiae]
Length = 560
Score = 108 bits (269), Expect = 1e-24
Identities = 88/312 (28%), Positives = 151/312 (48%), Gaps = 42/312 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG------VPSTAI-REIS 53
+ NF+ + +G G YG V AR+ TG +VA+K + + G V + + +EI
Sbjct: 47 LNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIE 106
Query: 54 LLKELNHPNIVKLLDVIHT--ENKLYLVFEFLHQDLKKF-----MDASALTGIPLPLIKS 106
++K +H N+V+L ++++ K+YLV E+ + K+ M+ A+ L +S
Sbjct: 107 VMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQS 166
Query: 107 --YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA--RAFGVPVRTYTHE 162
+ ++ GL + HS + HRD+KP NLLI++ G +K++DFG+A A G +HE
Sbjct: 167 RKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHE 226
Query: 163 VV-------TLWYRAPEILLGCKYY--STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLF 213
+ T + APE+ K Y S+A+DIWSLG ++ + F +S ++
Sbjct: 227 QLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLE--- 283
Query: 214 RIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK 273
++ + + P PS+ + S + D + LL ++L DP+K
Sbjct: 284 ------------LFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDK 331
Query: 274 RISAKAALAHPF 285
RI HPF
Sbjct: 332 RIKLADIKVHPF 343
>ref|NP_012821.1| (NC_001143) Negative regulator of swe1 kinase (which regulates
cdc28); Hsl1p [Saccharomyces cerevisiae]
Length = 1518
Score = 107 bits (266), Expect = 3e-24
Identities = 86/316 (27%), Positives = 142/316 (44%), Gaps = 70/316 (22%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKI---------------------RLDTETEGVPSTA 48
+G+G+ G V A+N TG++ A+K + + T PS A
Sbjct: 87 LGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIA 146
Query: 49 I---------------REISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDA 93
REI ++K ++H N++ L +V +++LYLV E++ D + D
Sbjct: 147 SREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYV--DGGELFDY 204
Query: 94 SALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARA 151
G +P Y Q+++G+++CHS + HRDLKP+NLL++ + IK+ADFG+A A
Sbjct: 205 LVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMA-A 263
Query: 152 FGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQ 211
+P + + Y +PEI++G Y+ D+WS G + ++T F D+
Sbjct: 264 LELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKL 323
Query: 212 LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDP 271
L + V G MP L + R L+S++L DP
Sbjct: 324 LLK-----------VQSGKYQMPS------------------NLSSEARDLISKILVIDP 354
Query: 272 NKRISAKAALAHPFFQ 287
KRI+ + L HP +
Sbjct: 355 EKRITTQEILKHPLIK 370
>ref|NP_015115.1| (NC_001148) Regulation of yeast chromosome segregation; Ipl1p
[Saccharomyces cerevisiae]
Length = 367
Score = 106 bits (265), Expect = 4e-24
Identities = 78/288 (27%), Positives = 138/288 (47%), Gaps = 37/288 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELN 59
+++F+ +K+G+G +G VY R++ TG + ALK + + + + RE+ + LN
Sbjct: 101 LDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLN 160
Query: 60 HPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKS-YLFQLLQGLAF 117
HPN+ K H E ++YL+ E+L + ++ K + L G ++ S Y++Q+ L +
Sbjct: 161 HPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLL---RLHGPFNDILASDYIYQIANALDY 217
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177
H ++HRD+KP+N+LI IKL DFG + P T+ Y +PE ++
Sbjct: 218 MHKKNIIHRDIKPENILIGFNNVIKLTDFGWS-IINPPENRRKTVCGTIDYLSPE-MVES 275
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237
+ Y +D W+LG + E++T G P P M D
Sbjct: 276 REYDHTIDAWALGVLAFELLT---------------------GAP-----PFEEEMKD-- 307
Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
++ + A D K+ + +D + L+ ++L YDP R+ HP+
Sbjct: 308 TTYKRIAALDI-KMPSNISQDAQDLILKLLKYDPKDRMRLGDVKMHPW 354
>ref|NP_011856.1| (NC_001140) Involved in pheromone response and pseudohyphal growth
pathways; Ste20p [Saccharomyces cerevisiae]
Length = 939
Score = 103 bits (258), Expect = 2e-23
Identities = 73/225 (32%), Positives = 111/225 (48%), Gaps = 18/225 (8%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+ + KIG+G G VY A T VA+K++ L+ + + I EI ++K HPNI
Sbjct: 620 YANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPK--KELIINEILVMKGSKHPNI 677
Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKS------YLFQLLQGLAF 117
V +D + L+++ E+ M+ +LT + I + + L GL F
Sbjct: 678 VNFIDSYVLKGDLWVIMEY--------MEGGSLTDVVTHCILTEGQIGAVCRETLSGLEF 729
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177
HS VLHRD+K N+L++ EG IKL DFG T V T ++ APE+ +
Sbjct: 730 LHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEV-VSR 788
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222
K Y VDIWSLG + EM+ + ++ + L+ + T GTP
Sbjct: 789 KEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALY-LIATNGTP 832
>ref|NP_010811.1| (NC_001136) dispensable for mitosis, involved in middle/late stage
of meiosis, required for spore wall formation; Sps1p
[Saccharomyces cerevisiae]
Length = 490
Score = 100 bits (249), Expect = 3e-22
Identities = 80/284 (28%), Positives = 136/284 (47%), Gaps = 34/284 (11%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
IG G +G VYKA +++T E+VA+K + L+ E + A +EI L EL P I +
Sbjct: 24 IGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLA-QEIFFLAELKSPLITNYIAT 82
Query: 70 IHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDL 128
+ + +++V E+ + S + G+P + + ++ GL + H R +HRD+
Sbjct: 83 MLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDI 142
Query: 129 KPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY--YSTAVDI 186
K N+L+N EG +KL DFG++ ++ T V T ++ APE++ C+ Y+ DI
Sbjct: 143 KAANILLNEEGMVKLGDFGVSGHIRSTLKRDTF-VGTPYWMAPEVVC-CEVDGYNEKADI 200
Query: 187 WSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ 246
WSLG E++ P S+ D P +V +T++P KP
Sbjct: 201 WSLGITTYELLKG---LPPLSKYD-----------PMKV----MTNLPKRKP-------- 234
Query: 247 DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290
K+ P + + ++ L P R SA L+ F +++T
Sbjct: 235 --PKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVKNIT 276
>ref|NP_011970.1| (NC_001140) Kinase that interacts with Cdc31p; N-rich kinase 1;
Kic1p [Saccharomyces cerevisiae]
Length = 1080
Score = 100 bits (248), Expect = 4e-22
Identities = 66/197 (33%), Positives = 98/197 (49%), Gaps = 6/197 (3%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH-PN 62
F++ E IG G +GVVYK N TG V A+K + LD++++ V REI L L N
Sbjct: 23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQ-REIQFLASLKQISN 81
Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
I + + L+++ E L+ + + + +I + +LL L H
Sbjct: 82 ITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVI---MRELLVALKCIHKD 138
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
V+HRD+K N+LI EG +KL DFG+A T ++ APE+++ YY
Sbjct: 139 NVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYD 198
Query: 182 TAVDIWSLGCIFAEMVT 198
T VDIWSLG E+ T
Sbjct: 199 TKVDIWSLGITTYEIAT 215
>ref|NP_013466.1| (NC_001144) involved in the mating signalling pathway; Ste11p
[Saccharomyces cerevisiae]
Length = 717
Score = 99.4 bits (246), Expect = 6e-22
Identities = 83/330 (25%), Positives = 140/330 (42%), Gaps = 77/330 (23%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR----------- 50
+N+ K IG G++G VY N TGE++A+K++ + GVP+ +
Sbjct: 413 KNWLKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQE 472
Query: 51 -------------------------------EISLLKELNHPNIVKLLDVIHTENKLYLV 79
E++LLKEL+H NIV L +
Sbjct: 473 EQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIF 532
Query: 80 FEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG 139
E++ M + LI ++ Q+L G+A+ H ++HRD+K N+LI+ +G
Sbjct: 533 LEYVPGGSVSSM-LNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKG 591
Query: 140 AIKLADFGLARAFGVPVRTYTHEVVTL----WYRAPEILLGCKYYSTAVDIWSLGCIFAE 195
+K+ DFG+++ P+ ++ +L ++ +PE++ + A DIWS GC+ E
Sbjct: 592 CVKITDFGISKKLS-PLNKKQNKRASLQGSVFWMSPEVVKQTATTAKA-DIWSTGCVVIE 649
Query: 196 MVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPL 255
M T + FP S++ +F+I GT + P P WA
Sbjct: 650 MFTGKHPFPDFSQMQAIFKI----GT-------------NTTPEIPSWA----------- 681
Query: 256 DEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
+G++ L + D R SA L HP+
Sbjct: 682 TSEGKNFLRKAFELDYQYRPSALELLQHPW 711
>ref|NP_010182.1| (NC_001136) DNA damage response; Dun1p [Saccharomyces cerevisiae]
Length = 513
Score = 99.0 bits (245), Expect = 8e-22
Identities = 90/307 (29%), Positives = 139/307 (44%), Gaps = 52/307 (16%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIRE-ISLLKELNHPNIVKL 66
+++G G Y +V +A+NK TG+ VA+K + + RE ++L + HPNIV L
Sbjct: 204 KELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIVNL 263
Query: 67 LD-----VIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
LD + ++ + YLV E + D + F T + K+ QLL GL + H
Sbjct: 264 LDSFVEPISKSQIQKYLVLEKI-DDGELFERIVRKTCLRQDESKALFKQLLTGLKYLHEQ 322
Query: 122 RVLHRDLKPQNLLIN-------------------TEGAIKLADFGLARAFGVPVRTYTHE 162
++HRD+KP+N+L+N + +K+ADFGLA+ G T T
Sbjct: 323 NIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKFTGEMQFTNT-L 381
Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222
T Y APE+L K Y++ VD+WS G I + FP S DQL
Sbjct: 382 CGTPSYVAPEVLTK-KGYTSKVDLWSAGVILYVCLCG---FPPFS--DQL---------- 425
Query: 223 DEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282
P K + +S +D+ L+S +L +P++R + AL
Sbjct: 426 ---------GPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNLLVLNPDERYNIDEALN 476
Query: 283 HPFFQDV 289
HP+F D+
Sbjct: 477 HPWFNDI 483
>ref|NP_014428.1| (NC_001146) Suppressor of Sensor Kinase (SLN1); Ssk2p [Saccharomyces
cerevisiae]
Length = 1579
Score = 96.7 bits (239), Expect = 4e-21
Identities = 89/324 (27%), Positives = 138/324 (42%), Gaps = 66/324 (20%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET--EGVPSTAIREISLLKELNHP 61
+QK IG GT+G VY A + GE++A+K+I + + + E+S+L+ LNHP
Sbjct: 1266 WQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHP 1325
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV V +K+ + E+ L ++ + + + Y QLL+GLA+ H
Sbjct: 1326 NIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDEMVTQV--YTLQLLEGLAYLHE 1383
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFG-----------VPVRTYTHEVV----- 164
++HRD+KP+N+L++ G IK DFG A+ + HE V
Sbjct: 1384 SGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHEDVTHVSD 1443
Query: 165 ----------------TLWYRAPEILLG--CKYYSTAVDIWSLGCIFAEMVT-RRALFPG 205
T Y APE + G K A D+WSLGC+ EM+T RR
Sbjct: 1444 SKAVKNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANL 1503
Query: 206 DSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ 265
D+E ++ + + P FP + + S G L +
Sbjct: 1504 DNEWAIMYHV-----------------AAGHTPQFP--TKDEVSSA-------GMKFLER 1537
Query: 266 MLHYDPNKRISAKAALAHPFFQDV 289
L +P+KR SA L P+ +
Sbjct: 1538 CLIQNPSKRASAVELLMDPWIVQI 1561
>ref|NP_012796.1| (NC_001143) 76.5 kDa Serine/threonine protein kinase with
similarity to protein kinase C, is 90% identical to
Ypk2p; Ypk1p [Saccharomyces cerevisiae]
Length = 680
Score = 94.7 bits (234), Expect = 2e-20
Identities = 87/297 (29%), Positives = 133/297 (44%), Gaps = 41/297 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD-TETEGVPSTAIREISLLKELN 59
+++F ++ IG+G++G V + R K T +V ALK IR ++ + + E ++L ++
Sbjct: 344 IDDFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVD 403
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
P IV L + KLY V F++ + F L + Y +LL L H
Sbjct: 404 CPFIVPLKFSFQSPEKLYFVLAFINGG-ELFYHLQKEGRFDLSRARFYTAELLCALDNLH 462
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
V++RDLKP+N+L++ +G I L DFGL + T Y APE+LLG
Sbjct: 463 KLDVVYRDLKPENILLDYQGHIALCDFGLCKLNMKDDDKTDTFCGTPEYLAPELLLGLG- 521
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
Y+ AVD W+LG + EM+T G P P Y
Sbjct: 522 YTKAVDWWTLGVLLYEMLT---------------------GLP-----------PYYDED 549
Query: 240 FPKWARQDFSK--VVPP-LDEDGRSLLSQMLHYDPNKRISAKAA---LAHPFFQDVT 290
PK ++ + V P D D + LL +L DP +R+ A HPFF ++
Sbjct: 550 VPKMYKKILQEPLVFPDGFDRDAKDLLIGLLSRDPTRRLGYNGADEIRNHPFFSQLS 606
>ref|NP_014528.1| (NC_001147) Serine/threonine protein kinase with similarity to
Ste20p and Cla4p; Skm1p [Saccharomyces cerevisiae]
Length = 655
Score = 94.7 bits (234), Expect = 2e-20
Identities = 67/238 (28%), Positives = 118/238 (49%), Gaps = 29/238 (12%)
Query: 4 FQKVEKIGEGTYGVVYKAR-----------------NKLTGEVVALKKIRLDTETEGVPS 46
FQ VEK G+G G VY ++ +++ GE VA+K+IRL + +
Sbjct: 360 FQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPK--KQ 417
Query: 47 TAIREISLLKELNHPNIVKLLDV-IHTENKLYLVFEFLHQD-LKKFMDASALTGI---PL 101
+ E+ ++ + NIV L+ I + +L+++ E++ L +DA A +
Sbjct: 418 LIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSS 477
Query: 102 PLIKSYLFQLL----QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR 157
PL ++ + ++ QGL F H+ +++HRD+K N+L+N++G +K+ DFG
Sbjct: 478 PLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRS 537
Query: 158 TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRI 215
V T ++ APEI + K Y VD+WSLG + EM+ + + + L+ I
Sbjct: 538 KRATMVGTPYWMAPEI-VNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLI 594
>ref|NP_009445.1| (NC_001134) Protein Kinase C; Pkc1p [Saccharomyces cerevisiae]
Length = 1151
Score = 94.4 bits (233), Expect = 2e-20
Identities = 72/236 (30%), Positives = 126/236 (52%), Gaps = 20/236 (8%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPST-AIREISLLK- 56
++NF ++ +G+G +G V +++K T + A+K ++ D + + S A +++ LL
Sbjct: 821 LDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLAT 880
Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
+ HP + L TEN++Y EF+ DL + L+ + K Y ++L L
Sbjct: 881 KTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQRLS---VRRAKFYAAEVLLAL 937
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA---FGVPVRTYTHEVVTLWYRAPE 172
+ H + V++RDLK +N+L+ EG IK+AD+GL + +G T+ T + APE
Sbjct: 938 KYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCG---TPEFMAPE 994
Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228
IL + Y+ AVD W+ G + +M+ ++ F GD E D++F T DE ++P
Sbjct: 995 ILKE-QEYTKAVDWWAFGVLLYQMLLCQSPFSGDDE-DEVFNAILT----DEPLYP 1044
>ref|NP_010754.1| (NC_001136) Hypothetical ORF; Ydr466wp [Saccharomyces cerevisiae]
Length = 898
Score = 94.0 bits (232), Expect = 3e-20
Identities = 79/308 (25%), Positives = 129/308 (41%), Gaps = 52/308 (16%)
Query: 8 EKIGEGTYGVVYKAR-----NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
E++G G+Y V+KA NK+ V KK + + ++LL + +H
Sbjct: 15 EELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHHAG 74
Query: 63 IVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
I+KL H E LY V +F + L I + + QL+ L F HS
Sbjct: 75 IIKLYYTFHDEENLYFVLDFAPGGELLSLLHKMGTFNDI---WTRHFTAQLIDALEFIHS 131
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-----------------RTYTHEV 163
H ++HRDLKP+N+L++ +G + + DFG A + + V
Sbjct: 132 HGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKFNSDSNGSKDNQNCASFV 191
Query: 164 VTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221
T Y +PE+LL C Y S DIW+LGC+ + V + F G++E+ +I
Sbjct: 192 GTAEYVSPELLLYNQCGYGS---DIWALGCMIYQFVQGQPPFRGENELKTFEKIVAL--- 245
Query: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281
+P + P++ +L+ ++L + N+RIS +
Sbjct: 246 -----------------DYPWGPNNRINNSTSPINPLVINLVQKILVIEVNERISLEQIK 288
Query: 282 AHPFFQDV 289
HP+F V
Sbjct: 289 RHPYFSKV 296
>ref|NP_012075.1| (NC_001140) protein kinase involved in growth control, may be
redundant with cAMP pathway; Sch9p [Saccharomyces
cerevisiae]
Length = 824
Score = 93.2 bits (230), Expect = 4e-20
Identities = 84/297 (28%), Positives = 138/297 (46%), Gaps = 41/297 (13%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI--RLDTETEGVPSTAIREISLL---K 56
++F+ + +G+GT+G VY+ + K T + A+K + ++ + + T I E ++L
Sbjct: 410 QDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHT-IGERNILVTTA 468
Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116
+ P IV L T LYLV +++ + F K Y+ +L+ L
Sbjct: 469 SKSSPFIVGLKFSFQTPTDLYLVTDYMSGG-ELFWHLQKEGRFSEDRAKFYIAELVLALE 527
Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
H + +++RDLKP+N+L++ G I L DFGL++A + RT T T Y APE+LL
Sbjct: 528 HLHDNDIVYRDLKPENILLDANGNIALCDFGLSKA-DLKDRTNTF-CGTTEYLAPELLLD 585
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
Y+ VD WSLG + EM + F ++ +I G
Sbjct: 586 ETGYTKMVDFWSLGVLIFEMCCGWSPFFAENNQKMYQKI--AFG---------------- 627
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA----KAALAHPFFQDV 289
K FP+ L ++GRS + +L+ +P R+ A + AHPFF D+
Sbjct: 628 KVKFPR----------DVLSQEGRSFVKGLLNRNPKHRLGAIDDGRELRAHPFFADI 674
>ref|NP_015121.1| (NC_001148) Involved in nutrient control of cell growth and
division; Tpk2p [Saccharomyces cerevisiae]
Length = 380
Score = 93.2 bits (230), Expect = 4e-20
Identities = 76/297 (25%), Positives = 139/297 (46%), Gaps = 44/297 (14%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58
+ +FQ + +G G++G V+ R+ G A+K ++ + + V T E +LK +
Sbjct: 67 LHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTN-DERRMLKLV 125
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
HP ++++ +++V +++ + F P P+ K Y +++ L +
Sbjct: 126 EHPFLIRMWGTFQDARNIFMVMDYIEGG-ELFSLLRKSQRFPNPVAKFYAAEVILALEYL 184
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGC 177
H+H +++RDLKP+N+L++ G IK+ DFG A+ V+T T + T Y APE++
Sbjct: 185 HAHNIIYRDLKPENILLDRNGHIKITDFGFAK----EVQTVTWTLCGTPDYIAPEVIT-T 239
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237
K Y+ +VD WSLG + EM+ F + + +I + +VV+P
Sbjct: 240 KPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQ-----GKVVYP--------- 285
Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289
P D LLS+++ D +RI ++ AHP+F +V
Sbjct: 286 ---------------PYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEV 327
>ref|NP_014216.1| (NC_001146) protein kinase homolog; Npr1p [Saccharomyces
cerevisiae]
Length = 790
Score = 92.8 bits (229), Expect = 6e-20
Identities = 70/238 (29%), Positives = 114/238 (47%), Gaps = 12/238 (5%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKL 66
+G G G V A+ ++ A+K+ R E E + E + LNHPNI++
Sbjct: 444 LGAGAGGSVKLAQRISDNKIFAVKEFRTKFENESKRDYVKKITSEYCIGTTLNHPNIIET 503
Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126
+++++ +++ V E+ DL + ++ ++ I Q+L G+ + HS + HR
Sbjct: 504 IEIVYENDRILQVMEYCEYDLFAIVMSNKMS---YEEICCCFKQILTGVQYLHSIGLAHR 560
Query: 127 DLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW----YRAPEILLGCKYYST 182
DLK N +IN +G +KL DFG A F P E + Y APE+ + KY
Sbjct: 561 DLKLDNCVINEKGIVKLIDFGAAVVFSYPFSKNLVEASGIVGSDPYLAPEVCIFAKYDPR 620
Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
VDIWS IFA M+ ++ + D F++F + G + + VT PD PS+
Sbjct: 621 PVDIWSSAIIFACMILKKFPWKIPKLRDNSFKLFCS-GRDCDSLSSLVTRTPD-PPSY 676
>ref|NP_009584.1| (NC_001134) Hypothetical ORF; Ybr028cp [Saccharomyces cerevisiae]
Length = 525
Score = 92.4 bits (228), Expect = 7e-20
Identities = 69/244 (28%), Positives = 111/244 (45%), Gaps = 39/244 (15%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR----------LDTETEGVPST--- 47
+ +F+ V +G+G YG V ++ T ++ A+K++R D++ E
Sbjct: 125 LHDFKPVRVLGQGAYGKVLLVKDVNTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGN 184
Query: 48 --------------AIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDA 93
E S+L E+ HPNIVKL H +KLYL+ +++ + F
Sbjct: 185 NNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGG-ELFYHL 243
Query: 94 SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFG 153
+ + Y ++ L F H+ V++RDLKP+N L+N G + L DFGL++
Sbjct: 244 KEHGTLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSA 303
Query: 154 ----------VPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALF 203
V + T Y APEILLG K YS D +SLGC+ +M+ + +
Sbjct: 304 NDSAVDEEDPENVNALYSIIGTPEYCAPEILLG-KAYSQNCDWYSLGCLLYDMLVGKPPY 362
Query: 204 PGDS 207
G +
Sbjct: 363 TGSN 366
>ref|NP_013822.1| (NC_001145) protein kinase; Ypk2p [Saccharomyces cerevisiae]
Length = 677
Score = 92.4 bits (228), Expect = 7e-20
Identities = 86/299 (28%), Positives = 135/299 (44%), Gaps = 45/299 (15%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPST-AIREISLLKELN 59
+++F ++ IG+G++G V + R K T ++ ALK +R T + E ++L ++
Sbjct: 341 IDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVD 400
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
P IV L + KLYLV F++ + F L + Y+ +LL L H
Sbjct: 401 CPFIVPLKFSFQSPEKLYLVLAFINGG-ELFYHLQHEGRFSLARSRFYIAELLCALDSLH 459
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
V++RDLKP+N+L++ +G I L DFGL + T Y APEILLG +
Sbjct: 460 KLDVIYRDLKPENILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLG-QG 518
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
Y+ VD W+LG + EM+T G P P Y +
Sbjct: 519 YTKTVDWWTLGILLYEMMT---------------------GLP-----------PYYDEN 546
Query: 240 FPKWARQDFSKVVPPLDEDG-----RSLLSQMLHYDPNKRISAKAA---LAHPFFQDVT 290
P ++ + P L DG + LL +L DP++R+ HPFF+D++
Sbjct: 547 VPVMYKKILQQ--PLLFPDGFDPAAKDLLIGLLSRDPSRRLGVNGTDEIRNHPFFKDIS 603
>ref|NP_010067.1| (NC_001136) Prr2p [Saccharomyces cerevisiae]
Length = 699
Score = 92.0 bits (227), Expect = 1e-19
Identities = 74/293 (25%), Positives = 130/293 (44%), Gaps = 16/293 (5%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS---TAIREISLLKELNHPNIVKL 66
+GEG+ G V + L +V ALK+ R + E I E + L +PNI +
Sbjct: 367 LGEGSGGKVKLVQRVLDNKVFALKEYRSKKKRESERKYIKNIISEYCIASTLKNPNICET 426
Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126
L++++ + K++ + E+ DL + + + I QL+ G+ + H + HR
Sbjct: 427 LEILYEKGKIFQILEYCEYDLFSLVMSEKMH---YEEICCLFKQLINGVKYLHDIGLSHR 483
Query: 127 DLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE----VVTLWYRAPEILLGCKYYST 182
DLK N ++ G +KL DFG + F P+ + E V + Y +PE+ +Y
Sbjct: 484 DLKLDNCVVTRRGILKLIDFGASSVFHYPLSSQMIEANGIVGSDPYLSPEVFYFNEYDPR 543
Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF----RTLGTPDEVVWPGVTSMPDYKP 238
A+D+WS+G IF M+TRR + D F+ F D V P +Y
Sbjct: 544 ALDVWSVGIIFFCMITRRFPWKYPKVKDVQFKAFCSGRGVSSFKDLVTRPATDDSNNYDN 603
Query: 239 SFPKWARQDFSK--VVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
+ D ++ L E+ ++ ++L P +RI+ L + +++
Sbjct: 604 DGYEEGVIDMGPNFILHRLPEETHKIMRRILEVSPFRRITINGILQDGWIKEI 656
>ref|NP_014910.1| (NC_001147) Hypothetical ORF; Yor267cp [Saccharomyces cerevisiae]
Length = 759
Score = 91.7 bits (226), Expect = 1e-19
Identities = 71/218 (32%), Positives = 105/218 (47%), Gaps = 15/218 (6%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNHPNIVKL 66
+G G G V G A+K+ R E V A + E + L+HPN+++
Sbjct: 221 LGSGAGGSVKVLVRPTDGATFAVKEFRPRKPNESVKEYAKKCTAEFCIGSTLHHPNVIET 280
Query: 67 LDVIHT--ENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRV 123
+DV +NK Y V E+ D A +TG + I L QL +G+ + HS +
Sbjct: 281 VDVFSDSKQNKYYEVMEYCPIDFF----AVVMTGKMSRGEINCCLKQLTEGVKYLHSMGL 336
Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR---TYTHEVV-TLWYRAPEILLGCKY 179
HRDLK N ++ ++G +KL DFG A F P T H +V + Y APE++ K
Sbjct: 337 AHRDLKLDNCVMTSQGILKLIDFGSAVVFRYPFEDGVTMAHGIVGSDPYLAPEVITSTKS 396
Query: 180 YS-TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216
Y VDIWS+G I+ MV +R + + D FR++
Sbjct: 397 YDPQCVDIWSIGIIYCCMVLKRFPWKAPRDSDDNFRLY 434
>ref|NP_012371.1| (NC_001142) putative catalytic subunit of cAMP-dependent protein
kinase; Tpk1p [Saccharomyces cerevisiae]
Length = 397
Score = 90.5 bits (223), Expect = 3e-19
Identities = 74/295 (25%), Positives = 142/295 (48%), Gaps = 42/295 (14%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKELN 59
+NFQ + +G G++G V+ R++ G A+K ++ + + V T + +L +
Sbjct: 85 KNFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERL-MLSIVT 143
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
HP I+++ +++++ +++ + F P P+ K Y ++ L + H
Sbjct: 144 HPFIIRMWGTFQDAQQIFMIMDYIEGG-ELFSLLRKSQRFPNPVAKFYAAEVCLALEYLH 202
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
S +++RDLKP+N+L++ G IK+ DFG A+ VP TYT T Y APE+ + K
Sbjct: 203 SKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYT-LCGTPDYIAPEV-VSTKP 258
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
Y+ ++D WS G + EM+ F + T+ T ++++ + +
Sbjct: 259 YNKSIDWWSFGILIYEMLAGYTPFYDSN----------TMKTYEKIL--------NAELR 300
Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289
FP P +ED + LLS+++ D ++R+ + HP+F++V
Sbjct: 301 FP-----------PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEV 344
>ref|NP_012755.1| (NC_001143) Involved in nutrient control of cell growth and
division; Tpk3p [Saccharomyces cerevisiae]
Length = 398
Score = 90.1 bits (222), Expect = 4e-19
Identities = 61/199 (30%), Positives = 106/199 (52%), Gaps = 8/199 (4%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58
+ +FQ + +G G++G V+ R+ G ALK ++ T + + V T E +L +
Sbjct: 85 LSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTN-DERRMLSIV 143
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
+HP I+++ ++++V +++ + F P P+ K Y ++ L +
Sbjct: 144 SHPFIIRMWGTFQDSQQVFMVMDYIEGG-ELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 202
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
HS +++RDLKP+N+L++ G IK+ DFG A+ VP TYT T Y APE+ + K
Sbjct: 203 HSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYT-LCGTPDYIAPEV-VSTK 258
Query: 179 YYSTAVDIWSLGCIFAEMV 197
Y+ +VD WS G + EM+
Sbjct: 259 PYNKSVDWWSFGVLIYEML 277
>ref|NP_011335.1| (NC_001139) Required for autophagy; Apg1p [Saccharomyces
cerevisiae]
Length = 897
Score = 90.1 bits (222), Expect = 4e-19
Identities = 89/330 (26%), Positives = 147/330 (43%), Gaps = 79/330 (23%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEV---VALKKI-RLDTETEGVPSTAIREISLLKEL 58
N+ ++IG+G++ VY R LT + VA+K++ R + + + EI++LK++
Sbjct: 23 NYTAEKEIGKGSFATVY--RGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKI 80
Query: 59 NHPNIVKLLDVIHTENKLYLVFE--------FLHQDLKKFMDASAL-------------- 96
HP+IV L+D T YL+ E FL + K+ M+ L
Sbjct: 81 KHPHIVGLIDCERTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSEN 140
Query: 97 -TGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE----------------- 138
G+ + SYL QL L F S ++HRD+KPQNLL++T
Sbjct: 141 HNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVG 200
Query: 139 ----GAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKYYSTAVDIWSLGCIF 193
+K+ADFG AR +P + + + Y APEIL KY + A D+WS+G +
Sbjct: 201 IYNLPILKIADFGFARF--LPNTSLAETLCGSPLYMAPEILNYQKYNAKA-DLWSVGTVV 257
Query: 194 AEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVP 253
EM F + ++ +F+ + ++V+ +FP + + P
Sbjct: 258 FEMCCGTPPFRASNHLE----LFKKIKRANDVI------------TFP-----SYCNIEP 296
Query: 254 PLDEDGRSLLSQMLHYDPNKRISAKAALAH 283
L E L+ +L +DP +RI + A+
Sbjct: 297 ELKE----LICSLLTFDPAQRIGFEEFFAN 322
>ref|NP_010122.1| (NC_001136) Serine/threonine/tyrosine protein kinase of the
pheromone pathway, homologous to MAP kinase kinase
family; Ste7p [Saccharomyces cerevisiae]
Length = 515
Score = 89.7 bits (221), Expect = 5e-19
Identities = 77/293 (26%), Positives = 140/293 (47%), Gaps = 39/293 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59
+++ ++ KIG G G V KA + ++VA K I ++ + + +RE+S++K +
Sbjct: 188 LQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKP 247
Query: 60 HPNIVKLLDVI---HTENKLYLVFEF--------LHQDLKKFMD----ASALTGIPLPLI 104
H NI+ H N++ ++ E+ + K+F+ +S T I
Sbjct: 248 HENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTI 307
Query: 105 KSYLFQLLQGLAFCH-SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV 163
+ +L GL + ++++HRD+KP N+LIN++G IKL DFG+++ + +
Sbjct: 308 SKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKL---INSIADTF 364
Query: 164 V-TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222
V T Y +PE + G YS D+WSLG + E+VT G ++ TP
Sbjct: 365 VGTSTYMSPERIQG-NVYSIKGDVWSLGLMIIELVTGEFPLGGHND------------TP 411
Query: 223 DEVVWPGVTSMPDYKPSFPK---WARQ--DFSKVVPPLDEDGRSLLSQMLHYD 270
D ++ + + P PK ++++ DF +E RS + ++LH+D
Sbjct: 412 DGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHHD 464
>ref|NP_015185.1| (NC_001148) Member of MAP kinase pathway involving PKC1, BCK1, and
SLT2. Shows functional redundancy with MKK1; Mkk2p
[Saccharomyces cerevisiae]
Length = 506
Score = 89.7 bits (221), Expect = 5e-19
Identities = 83/288 (28%), Positives = 121/288 (41%), Gaps = 39/288 (13%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
+GEG G V K R K +V ALK I RE+ K IV+ +
Sbjct: 220 LGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGM 279
Query: 70 IHTE--NKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
E + +Y+ E+ L K + I +I +L+GL++ H +
Sbjct: 280 FTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR--ISERVIGKIAESVLRGLSYLHERK 337
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
V+HRD+KPQN+L+N +G IKL DFG++ A T+T T +Y APE + G + YS
Sbjct: 338 VIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTG---TSFYMAPERIQG-QPYS 393
Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241
D+WSLG E+ R F D + P E++ +T P K
Sbjct: 394 VTCDVWSLGLTLLEVAGGRFPFESDKITQNV--------APIELLTMILTFSPQLKDE-- 443
Query: 242 KWARQDFSKVVPPLD----EDGRSLLSQMLHYDPNKRISAKAALAHPF 285
P LD + RS + L D +R S + L HP+
Sbjct: 444 -----------PELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPW 480
>ref|NP_014101.1| (NC_001146) Involved in localizing cell growth with respect to the
septin ring; Cla4p [Saccharomyces cerevisiae]
Length = 842
Score = 88.6 bits (218), Expect = 1e-18
Identities = 66/245 (26%), Positives = 113/245 (45%), Gaps = 30/245 (12%)
Query: 4 FQKVEKIGEGTYGVVYKARNKL-------------------TGEVVALKKIRLDTETEGV 44
F+ +EK G+G G VY A G+ VA+K++ L +
Sbjct: 546 FKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPR-- 603
Query: 45 PSTAIREISLLKELNHPNIVKLLDV-IHTENKLYLVFEFLH----QDLKKFMDASALTGI 99
+ EI ++K+ H NIV L+ + T++ L++V EF+ D+ + + +
Sbjct: 604 KELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHS 663
Query: 100 PL--PLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR 157
PL P I + + QGL F H ++HRD+K N+L++T +K+ DFG
Sbjct: 664 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRS 723
Query: 158 TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217
V T ++ APE++ + Y +D+WSLG + EM+ + + + L+ +
Sbjct: 724 KRATMVGTPYWMAPEVVKQ-REYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALY-LIA 781
Query: 218 TLGTP 222
T GTP
Sbjct: 782 TNGTP 786
>ref|NP_013714.1| (NC_001145) CDC5 is dispensable for premeiotic DNA synthesis and
recombination, but required for tripartite synaptonemal
complexes, haploidization, and spores; Cdc5p
[Saccharomyces cerevisiae]
Length = 705
Score = 88.6 bits (218), Expect = 1e-18
Identities = 70/275 (25%), Positives = 127/275 (45%), Gaps = 31/275 (11%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60
+++ + +GEG + ++ ++ +GE+ A K + + ++E + EI + K ++H
Sbjct: 80 KDYHRGHFLGEGGFARCFQIKDD-SGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSH 138
Query: 61 PNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
PNIV+ +D ++ +Y++ E + L + + + + P ++ + Q+ + + H
Sbjct: 139 PNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKV--LTEPEVRFFTTQICGAIKYMH 196
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG-CK 178
S RV+HRDLK N+ ++ +K+ DFGLA T Y APE+L+G
Sbjct: 197 SRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHS 256
Query: 179 YYSTAVDIWSLG-------------------CIFAEMVTRRALFPGDSEI-DQLFRIFRT 218
+S VDIWSLG I+ + R FP D I D+ + R
Sbjct: 257 GHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRD 316
Query: 219 LGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVP 253
+ + D + P +T + DY W R F +P
Sbjct: 317 ILSLDPIERPSLTEIMDY-----VWFRGTFPPSIP 346
>ref|NP_116669.1| (NC_001138) Calmodulin-dependent protein kinase; Cmk1p
[Saccharomyces cerevisiae]
Length = 446
Score = 88.2 bits (217), Expect = 1e-18
Identities = 82/289 (28%), Positives = 130/289 (44%), Gaps = 46/289 (15%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALK-KIRLDTETEGVPSTAIR-EISLLKELNHPNIVKLL 67
+G GT+GVV +A+N TGE VA+K I+ + V A+ E+ +L+ L+HPNIV
Sbjct: 43 LGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFK 102
Query: 68 DVIHTENKLYLVF------EFLHQDLKK--FMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
D +++K Y++ E + LKK F + A+ L ++L + + H
Sbjct: 103 DWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVR---------ILVEILSAVKYMH 153
Query: 120 SHRVLHRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
S ++HRDLKP+NLL + E + +ADFG+A+ +L Y APE+L
Sbjct: 154 SQNIVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQ 213
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
+ DIWS+G I ++ + F + D L DE T
Sbjct: 214 -DGHGKPCDIWSIGVITYTLLCGYSAFRAERVQDFL----------DEC----TTGEYPV 258
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
K P W + + + + L+ DP+KR +A L P+
Sbjct: 259 KFHRPYW---------DSVSNKAKQFILKALNLDPSKRPTAAELLEDPW 298
>ref|NP_010407.1| (NC_001136) Serine/threonine protein kinase; Kin1p [Saccharomyces
cerevisiae]
Length = 1064
Score = 87.8 bits (216), Expect = 2e-18
Identities = 77/309 (24%), Positives = 134/309 (42%), Gaps = 60/309 (19%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET-----EGVP------------ 45
+++ VE +G G+ G V A+++ T EV A+K + T+ + +P
Sbjct: 119 DWEFVETVGAGSMGKVKLAKHRYTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQ 178
Query: 46 ----------STAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASA 95
IRE SL + L HP+I +L ++ N Y++FE++ + +D
Sbjct: 179 KKLEKEISRDKRTIREASLGQILYHPHICRLFEMCTLSNHFYMLFEYVSGG--QLLDYII 236
Query: 96 LTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154
G I + + + L + H++ ++HRDLK +N++I+ IK+ DFGL+ +
Sbjct: 237 QHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDS 296
Query: 155 PVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214
+ +T +L++ APE+L Y VD+WS G + +V + P D E +
Sbjct: 297 RKQLHTF-CGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKV--PFDDENSSVLH 353
Query: 215 IFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 274
E + G P + L + SLLS+ML DP +R
Sbjct: 354 ---------EKIKQGKVEYPQH------------------LSIEVISLLSKMLVVDPKRR 386
Query: 275 ISAKAALAH 283
+ K + H
Sbjct: 387 ATLKQVVEH 395
>ref|NP_009833.1| (NC_001134) checkpoint kinase 1; homolog of the S. pombe and
mammalian Chk1 checkpoint kinases; Chk1p [Saccharomyces
cerevisiae]
Length = 527
Score = 87.0 bits (214), Expect = 3e-18
Identities = 76/288 (26%), Positives = 141/288 (48%), Gaps = 36/288 (12%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVV-ALKKIRLDT-ETEGVPSTAI-REISLLKELN-HPNI 63
+ +G+G + V A ++ ++ A+K I + T + G+ I +E+ L + + HPN+
Sbjct: 19 DTVGQGAFACVKNAHLQMDPSIILAVKFIHVPTCKKMGLSDKDITKEVVLQSKCSKHPNV 78
Query: 64 VKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH- 121
++L+D ++ ++++ E DL F G+ + + Y QL+ + + H
Sbjct: 79 LRLIDCNVSKEYMWIILEMADGGDL--FDKIEPDVGVDSDVAQFYFQQLVSAINYLHVEC 136
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLWYRAPEILLGCK 178
V HRD+KP+N+L++ G +KLADFGLA F +R + + Y APE+L +
Sbjct: 137 GVAHRDIKPENILLDKNGNLKLADFGLASQFRRKDGTLRVSMDQRGSPPYMAPEVLYSEE 196
Query: 179 -YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237
YY+ DIWS+G + ++T + + S ++ F F D
Sbjct: 197 GYYADRTDIWSIGILLFVLLTGQTPWELPSLENEDFVFF---------------IENDGN 241
Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
++ W++ +F+ + +LL ++L DPNKR++ KA HP+
Sbjct: 242 LNWGPWSKIEFTHL---------NLLRKILQPDPNKRVTLKALKLHPW 280
>ref|NP_013197.1| (NC_001144) Serine/threonine protein kinase; Kin2p [Saccharomyces
cerevisiae]
Length = 1147
Score = 87.0 bits (214), Expect = 3e-18
Identities = 76/321 (23%), Positives = 134/321 (41%), Gaps = 80/321 (24%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET-----EGVPST---------- 47
+++ +E +G G+ G V +++ T E+ +K + ++ +PS
Sbjct: 98 DWEFLETVGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQ 157
Query: 48 ------------AIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFL-----------H 84
+RE SL + L HP+I +L ++ N Y++FE++ H
Sbjct: 158 KRLEKEIARDKRTVREASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQH 217
Query: 85 QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLA 144
LK+ GI L + H++ ++HRDLK +N++I++ G IK+
Sbjct: 218 GSLKEHHARKFARGIA------------SALQYLHANNIVHRDLKIENIMISSSGEIKII 265
Query: 145 DFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP 204
DFGL+ F + +T +L++ APE+L Y VDIWS G + +V + P
Sbjct: 266 DFGLSNIFDYRKQLHTF-CGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKV--P 322
Query: 205 GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLS 264
D E + E + G P + L + SLL+
Sbjct: 323 FDDENSSILH---------EKIKKGKVDYPSH------------------LSIEVISLLT 355
Query: 265 QMLHYDPNKRISAKAALAHPF 285
+M+ DP +R + K + HP+
Sbjct: 356 RMIVVDPLRRATLKNVVEHPW 376
>ref|NP_010256.1| (NC_001136) Required for spindle pole body duplication and a
mitotic checkpoint function.; Mps1p [Saccharomyces
cerevisiae]
Length = 764
Score = 86.3 bits (212), Expect = 5e-18
Identities = 74/303 (24%), Positives = 129/303 (42%), Gaps = 44/303 (14%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPN 62
++K+E +G G VYK + V ALK++ D + EI LL++L +
Sbjct: 440 YEKIELLGRGGSSRVYKVKGS-GNRVYALKRVSFDAFDDSSIDGFKGEIELLEKLKDQKR 498
Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
+++LLD + LYL+ E DL + ++ + + ++ Y ++L + H
Sbjct: 499 VIQLLDYEMGDGLLYLIMECGDHDLSQILNQRSGMPLDFNFVRFYTKEMLLCIKVVHDAG 558
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT----HEVVTLWYRAPEILLGCK 178
++H DLKP N ++ +G +K+ DFG+A A VP T ++ T Y APE L+
Sbjct: 559 IVHSDLKPANFVL-VKGILKIIDFGIANA--VPEHTVNIYRETQIGTPNYMAPEALVAMN 615
Query: 179 YYSTA--------------VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224
Y + D+WS GCI +M+ + + ++L I
Sbjct: 616 YTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNRLLAIMN------- 668
Query: 225 VVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284
PD K FP+ + + + L+ L+ +P+KR + L+
Sbjct: 669 ---------PDVKIPFPEHTSNN-----EKIPKSAIELMKACLYRNPDKRWTVDKVLSST 714
Query: 285 FFQ 287
F Q
Sbjct: 715 FLQ 717
>ref|NP_011055.1| (NC_001137) high copy suppressor of temperature sensitive cdc17
(DNA polymerase alpha) mutations; Pak1p [Saccharomyces
cerevisiae]
Length = 1142
Score = 86.3 bits (212), Expect = 5e-18
Identities = 81/321 (25%), Positives = 155/321 (48%), Gaps = 39/321 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI----------- 49
+ ++ ++++G G +G V AR+ L+ ++VA+K + + + T I
Sbjct: 130 LNTYEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHEKKQRKFFTFIKSSKISENDKI 189
Query: 50 -REISLLKELNHPNIVKLLDVIHT--ENKLYLVFEFLHQDLKKFM-------DASALTGI 99
REI+++K+ +H ++V+L++V+ K+YLV E+ + K+ DA + +
Sbjct: 190 KREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRGEVKWCPPDCMESDAKGPSLL 249
Query: 100 PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY 159
+ L ++ GL + H ++HRD+KP NLLI+ +G +K++DFG++ A +
Sbjct: 250 SFQETREILRGVVLGLEYLHYQGIIHRDIKPANLLISGDGTVKISDFGVSLAASSTNSSD 309
Query: 160 THE----------VVTLWYRAPEILLG----CKYYSTAVDIWSLGCIFAEMVTRRALFPG 205
+ E V T + APE+ LG +Y T +++ CI + M+ A+ G
Sbjct: 310 SSESLDELELAKTVGTPAFFAPEMCLGEDAFTRYNLTKENLFRGSCI-SFMIDIWAV--G 366
Query: 206 DSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD-EDGRSLLS 264
+ LF + + ++ + + P P+F + SKV + E + LL
Sbjct: 367 VTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNKVSKVSCEEEYEMAKDLLL 426
Query: 265 QMLHYDPNKRISAKAALAHPF 285
++L +P KR++ A HPF
Sbjct: 427 KLLEKNPQKRMTIPAIKKHPF 447
>ref|NP_014445.1| (NC_001146) Hypothetical ORF; Ynr047wp [Saccharomyces cerevisiae]
Length = 893
Score = 85.5 bits (210), Expect = 9e-18
Identities = 84/316 (26%), Positives = 137/316 (42%), Gaps = 57/316 (18%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIREISLLKELNH 60
++F+K+ +G+G G V+ R K T V ALK + D + + E +L NH
Sbjct: 494 QSFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNH 553
Query: 61 PNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
P IV L +E+ LYL E+ + + + + I + Y ++ L + H
Sbjct: 554 PFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQTRKTKCICEDDARFYASEVTAALEYLH 613
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGL---ARAFGVPV-------------------R 157
++RDLKP+N+L++ G I L+DF L A+ VPV R
Sbjct: 614 LLGFIYRDLKPENILLHQSGHIMLSDFDLSIQAKDSKVPVVKGSAQSTLVDTKICSDGFR 673
Query: 158 TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217
T + V T Y APE++ G ++ AVD W+LG + EM+ F GD+ + I +
Sbjct: 674 TNSF-VGTEEYIAPEVIRG-NGHTAAVDWWTLGILIYEMLFGFTPFKGDNTNETFTNILK 731
Query: 218 TLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277
+EV +P + S+ + L+ ++L + +KR+
Sbjct: 732 -----NEVSFPN---------------NNEISRTC-------KDLIKKLLTKNESKRLGC 764
Query: 278 KAALA----HPFFQDV 289
K A HPFF+ V
Sbjct: 765 KMGAADVKKHPFFKKV 780
>ref|NP_010259.1| (NC_001136) Hypothetical ORF; Ydl025cp [Saccharomyces cerevisiae]
Length = 620
Score = 85.5 bits (210), Expect = 9e-18
Identities = 74/280 (26%), Positives = 122/280 (43%), Gaps = 35/280 (12%)
Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKIRLD-TETEGVPSTAIR--------EISLLKELN 59
K+GEG G V + G++ A K R EG + + E + L+
Sbjct: 307 KLGEGASGSV-SVVERTDGKLFACKMFRKPHLNNEGTNQSQLANYSKKVTTEFCIGSTLH 365
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
H NIV+ LD++ + LV E+ D + ++ +T + Y QL G+ + H
Sbjct: 366 HENIVETLDMLTEGDTYLLVMEYAPYDFFNLVMSNLMTQDE---VNCYFKQLCHGVNYLH 422
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR---TYTHEVV-TLWYRAPEILL 175
S + HRDLK N ++ +G +KL DFG A F P +H +V + Y APE+L
Sbjct: 423 SMGLAHRDLKLDNCVVTKDGILKLIDFGSAVVFQYPYEDTIVKSHGIVGSDPYLAPELLK 482
Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235
Y D+WS+ IF MV +R + + FR+F T P+
Sbjct: 483 QTSYDPRVADVWSIAIIFYCMVLKRFPWKAPKKSFNSFRLF--------------TEEPE 528
Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI 275
+ + +K++ L R+++ +ML +P +R+
Sbjct: 529 DEDDIVRGP----NKILRLLPRHSRTIIGRMLALEPKQRV 564
>ref|NP_011946.1| (NC_001140) Involved in myo-inositol biosynthesis; implicated as
the sensor of unfolded proteins in the ER that initiates
transmittance of the unfolded protein signal from the ER
to the nucleus; Ire1p [Saccharomyces cerevisiae]
Length = 1115
Score = 85.5 bits (210), Expect = 9e-18
Identities = 91/350 (26%), Positives = 154/350 (44%), Gaps = 83/350 (23%)
Query: 1 MENFQKVEKI-GEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 59
++N EKI G G+ G V + G VA+K++ +D A+ EI LL E +
Sbjct: 670 LKNLVVSEKILGYGSSGTVV-FQGSFQGRPVAVKRMLID-----FCDIALMEIKLLTESD 723
Query: 60 -HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSY-----LFQLLQ 113
HPN+++ T+ LY+ E + +L+ +++ ++ L L K Y L Q+
Sbjct: 724 DHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 783
Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEG-------------AIKLADFGLARAFGVPVRTY- 159
G+A HS +++HRDLKPQN+L++T I ++DFGL + ++
Sbjct: 784 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 843
Query: 160 ---THEVVTLWYRAPEIL-----LGCK-----------------YY--------STAVDI 186
+ T +RAPE+L L C+ +Y + ++DI
Sbjct: 844 TNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDI 903
Query: 187 WSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQ 246
+S+GC+F +++ + P + + I R G+ S+ + K
Sbjct: 904 FSMGCVFYYILS-KGKHPFGDKYSRESNIIR-----------GIFSLDEMK------CLH 945
Query: 247 DFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
D S + D L+SQM+ +DP KR +A L HP F +K + L
Sbjct: 946 DRSLIAEATD-----LISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFL 990
>ref|NP_116620.1| (NC_001138) RIM15 is glucose-repressed; RIM15 is required for IME2
expression; Rim15p [Saccharomyces cerevisiae]
Length = 1770
Score = 83.2 bits (204), Expect = 5e-17
Identities = 49/154 (31%), Positives = 83/154 (53%), Gaps = 5/154 (3%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58
++++ ++ I +G YG VY AR KLTG+ A+K +R V + ++ +
Sbjct: 791 IKDYDILKPISKGAYGSVYLARKKLTGDYFAIKVLRKSDMIAKNQVTNVKSERAIMMVQS 850
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
+ P + +L ++ L+LV E+L DL + +P K YL +++ G+
Sbjct: 851 DKPYVARLFASFQNKDNLFLVMEYLPGGDLATLIKMMGY--LPDQWAKQYLTEIVVGVND 908
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARA 151
H + ++H DLKP+NLLI+ G +KL DFGL+RA
Sbjct: 909 MHQNGIIHHDLKPENLLIDNAGHVKLTDFGLSRA 942
Score = 42.7 bits (99), Expect = 7e-05
Identities = 36/128 (28%), Positives = 57/128 (44%), Gaps = 29/128 (22%)
Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEV-- 225
Y APE + G + D WS+GCIF E++ F + TPD V
Sbjct: 1153 YLAPETIEGKGEDNKQCDWWSVGCIFFELLLGYPPFHAE--------------TPDAVFK 1198
Query: 226 -VWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-- 282
+ GV P++K + ++F L + + L+ ++L DP KR+ AK
Sbjct: 1199 KILSGVIQWPEFK---NEEEEREF------LTPEAKDLIEKLLVVDPAKRLGAKGIQEIK 1249
Query: 283 -HPFFQDV 289
HP+F++V
Sbjct: 1250 DHPYFKNV 1257
>ref|NP_012407.1| (NC_001142) Involved in osmoregulation, member of the HOG1
mitogen-activated protein kinase (MAPK) cascade; Pbs2p
[Saccharomyces cerevisiae]
Length = 668
Score = 83.2 bits (204), Expect = 5e-17
Identities = 62/221 (28%), Positives = 106/221 (47%), Gaps = 12/221 (5%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
++ + ++++G G YG V K +K T ++A K++RL+ + E + E+ +L + N
Sbjct: 357 LDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELD-EAKFRQILMELEVLHKCNS 415
Query: 61 PNIVKLLDVIHTENKLYLVFEFLH-QDLKKFMD-ASALTGIPLPLIKSYLFQLLQGL-AF 117
P IV E +Y+ E++ L K D +S + GI P + ++ GL
Sbjct: 416 PYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAFIANAVIHGLKEL 475
Query: 118 CHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
H ++HRD+KP N+L + +G +KL DFG++ + + Y APE +
Sbjct: 476 KEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSG--NLVASLAKTNIGCQSYMAPERIKS 533
Query: 177 CK----YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLF 213
Y+ DIWSLG EM R +P ++ D +F
Sbjct: 534 LNPDRATYTVQSDIWSLGLSILEMALGRYPYPPET-YDNIF 573
>ref|NP_010015.2| (NC_001135) Putative serine/threonine protein kinase most similar
to cyclic nucleotide-dependent protein kinase subfamily
and the protein kinase C subfamily; Kin82p
[Saccharomyces cerevisiae]
Length = 720
Score = 81.6 bits (200), Expect = 1e-16
Identities = 79/315 (25%), Positives = 140/315 (44%), Gaps = 58/315 (18%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL--- 58
++F+K+ +G+G G VY R + T ++ ALK + + E + I+ + +E+
Sbjct: 322 QSFEKIRLLGQGDVGKVYLMRERDTNQIFALKVLN---KHEMIKRKKIKRVLTEQEILAT 378
Query: 59 -NHPNIVKLLDVIHTENKLYLVFEF-LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116
+HP IV L T++ LYL E+ + + + + I K Y +++ L
Sbjct: 379 SDHPFIVTLYHSFQTKDYLYLCMEYCMGGEFFRALQTRKSKCIAEEDAKFYASEVVAALE 438
Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHE------------- 162
+ H ++RDLKP+N+L++ G + L+DF L+ +A G T
Sbjct: 439 YLHLLGFIYRDLKPENILLHQSGHVMLSDFDLSIQATGSKKPTMKDSTYLDTKICSDGFR 498
Query: 163 ----VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT 218
V T Y APE++ G ++ AVD W+LG + EM+ F GD+ + F
Sbjct: 499 TNSFVGTEEYLAPEVIRG-NGHTAAVDWWTLGILIYEMLFGCTPFKGDNSNE----TFSN 553
Query: 219 LGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK 278
+ T D P K + ++ + L+ ++L+ + KR+ +K
Sbjct: 554 ILTKD-------VKFPHDK----------------EVSKNCKDLIKKLLNKNEAKRLGSK 590
Query: 279 AALA----HPFFQDV 289
+ A HPFF+ V
Sbjct: 591 SGAADIKRHPFFKKV 605
>ref|NP_014541.1| (NC_001147) Pkb-activating Kinase Homologue; Pkh2p [Saccharomyces
cerevisiae]
Length = 1081
Score = 81.3 bits (199), Expect = 2e-16
Identities = 60/223 (26%), Positives = 106/223 (46%), Gaps = 19/223 (8%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58
+++F+ IG+G Y V A + T + A K + + + V +I + +L K
Sbjct: 176 IKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLN 235
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
N P++V+L E+ LY + E+ + D M + + Y Q++ + +
Sbjct: 236 NSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYG--SLDETCARYYAAQIIDAIDY 293
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR------------AFGVPVRTYTHEVVT 165
HS+ ++HRD+KP+N+L++ E IKL DFG A+ + + R+ + V T
Sbjct: 294 LHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSF-VGT 352
Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSE 208
Y +PE LL + DIW+ GCI +M+ + F +E
Sbjct: 353 AEYVSPE-LLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNE 394
>ref|NP_014874.1| (NC_001147) Mitogen-activated kinase-kinase involved in protein
kinase C pathway; Mkk1p [Saccharomyces cerevisiae]
Length = 508
Score = 81.3 bits (199), Expect = 2e-16
Identities = 64/208 (30%), Positives = 102/208 (48%), Gaps = 18/208 (8%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIR-LDTETEGVPSTAIREISLLKELNHPNIVKLLD 68
+GEG G V K + K ++ ALK I L+T+ E RE+ + IV+
Sbjct: 227 LGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPE-YQKQIFRELQFNRSFQSEYIVRYYG 285
Query: 69 VIHTE--NKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
+ + + +Y+ E+ L K ++ I ++ +L+GL++ H
Sbjct: 286 MFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGR--ISEKVLGKIAEAVLRGLSYLHEK 343
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
+V+HRD+KPQN+L+N G +KL DFG++ A T+T T +Y APE + G + Y
Sbjct: 344 KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTG---TSFYMAPERIQG-QPY 399
Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSE 208
S D+WSLG E+ + FP SE
Sbjct: 400 SVTSDVWSLGLTILEVANGK--FPCSSE 425
>ref|NP_014626.1| (NC_001147) Calmodulin-dependent protein kinase; Cmk2p
[Saccharomyces cerevisiae]
Length = 447
Score = 80.9 bits (198), Expect = 2e-16
Identities = 60/191 (31%), Positives = 96/191 (49%), Gaps = 13/191 (6%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVP---STAIREISLLKELNHPNIVKL 66
+G G++GVV +AR T E VA+K I L +G E+S+L++L+HPNIV
Sbjct: 53 LGAGSFGVVRQARKLSTNEDVAIK-ILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSF 111
Query: 67 LDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124
D +++K Y+V + + + + T + I + Q+L + + HS V+
Sbjct: 112 KDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEI---IVQILGAVEYMHSKNVV 168
Query: 125 HRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
HRDLKP+N+L + + +ADFG+A+ +L Y APE+L +
Sbjct: 169 HRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQ-DGHG 227
Query: 182 TAVDIWSLGCI 192
DIWS+G I
Sbjct: 228 KPCDIWSIGVI 238
>ref|NP_009410.1| (NC_001133) protein kinase; Kin3p [Saccharomyces cerevisiae]
Length = 435
Score = 80.1 bits (196), Expect = 4e-16
Identities = 72/274 (26%), Positives = 113/274 (40%), Gaps = 70/274 (25%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+Q +E+IG G++G V K + T +++ K I+ I E S+L +L H NI
Sbjct: 25 YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENI 84
Query: 64 VKLLDVIHTENK--LYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116
V+ + E K LYL E+ L Q +K + IP ++ L QLL L
Sbjct: 85 VEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKY--IPEKIVWGILAQLLTALY 142
Query: 117 FCH---------------------SHRVLHRDLKPQNLLIN------------------- 136
CH + V+HRDLKP N+ ++
Sbjct: 143 KCHYGVELPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVN 202
Query: 137 --------------------TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
++ +KL DFGLA++ ++ T V T +Y +PE+L+
Sbjct: 203 SNYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMD 262
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEID 210
+ YS DIWSLGC+ EM + F + ++
Sbjct: 263 -QPYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLE 295
>ref|NP_013081.1| (NC_001144) protein kinase homolog; Kns1p [Saccharomyces
cerevisiae]
Length = 737
Score = 80.1 bits (196), Expect = 4e-16
Identities = 69/253 (27%), Positives = 109/253 (42%), Gaps = 48/253 (18%)
Query: 10 IGEGTYGVVYKA-RNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN----IV 64
+G+GT+G V K NK VA+K IR T +R + + N P +
Sbjct: 319 LGQGTFGKVLKCIDNKYEPNYVAVKVIRAVDRYREAAKTELRILQTILN-NDPQGQFQCL 377
Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124
L + +N + LV + + + FM ++ + P I++ QL++ + F H ++
Sbjct: 378 LLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIARQLIRSVCFLHDLGII 437
Query: 125 HRDLKPQNLLINTE--------------------------------GAIKLADFGLA--- 149
H DLKP+N+LI E IK+ DFG A
Sbjct: 438 HTDLKPENILICDETHIAQKLPLKTVQSLSKRRREASKGKRKILKNPEIKIIDFGSAIFH 497
Query: 150 RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209
+ PV + H YRAPEI+LG +S DIWS+ C+ E+V +L+P +
Sbjct: 498 YEYHPPVISTRH------YRAPEIVLGLG-WSFPCDIWSIACVLVELVIGESLYPIHENL 550
Query: 210 DQLFRIFRTLGTP 222
+ + + R GTP
Sbjct: 551 EHMAMMQRINGTP 563
Score = 32.7 bits (73), Expect = 0.070
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 10/54 (18%)
Query: 243 WARQDFSKVVPPLDEDGRS----------LLSQMLHYDPNKRISAKAALAHPFF 286
W RQ S DE + LL +M +DP KRI+AK AL H +F
Sbjct: 667 WKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWF 720
>ref|NP_010778.1| (NC_001136) Pkb-activating Kinase Homologue; Pkh1p [Saccharomyces
cerevisiae]
Length = 766
Score = 79.7 bits (195), Expect = 5e-16
Identities = 75/309 (24%), Positives = 134/309 (43%), Gaps = 56/309 (18%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58
+++F+ E++G+G+Y V A + +G+ A+K + + + V + +++L K
Sbjct: 122 IKDFKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLN 181
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFL-HQD----LKKFMDASALTGIPLPLIKSYLFQLLQ 113
I KL E LY + E+ H D +KK+ + + Y Q++
Sbjct: 182 GTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKYGSLNETCA------RYYASQIID 235
Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR---------AFGVPVRTYTHE-- 162
+ H+ ++HRD+KP+N+L++ +KL DFG A+ A G P +
Sbjct: 236 AVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSK 295
Query: 163 --VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG 220
V T Y +PE LL Y + DIW+ GCI +M+ + F +E ++ +
Sbjct: 296 SFVGTAEYVSPE-LLNDNYTDSRCDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMK--- 351
Query: 221 TPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA 280
+ F+ P + +D L+ ++L DPN R++ K
Sbjct: 352 -----------------------IQYAFTAGFPQIVKD---LVKKLLVRDPNDRLTIKQI 385
Query: 281 LAHPFFQDV 289
AH FF +V
Sbjct: 386 KAHLFFHEV 394
>ref|NP_015184.1| (NC_001148) Hypothetical ORF; Ypl141cp [Saccharomyces cerevisiae]
Length = 865
Score = 79.7 bits (195), Expect = 5e-16
Identities = 72/270 (26%), Positives = 116/270 (42%), Gaps = 44/270 (16%)
Query: 30 VALKKIRLDTETEGVPSTA--IREISLLKELNHPNIVKLLDVIHTENKLYLVFEF----- 82
VA+K I+ D+ + REI+ LK L+HPNIVKL +V+ + +V E+
Sbjct: 77 VAIKLIKRDSISNDYRKEVKIYREINALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGE 136
Query: 83 LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIK 142
++ ++K + L QL+ G+ + HS ++HRDLK +NLL++ +
Sbjct: 137 FYKYIQKKRRLKEMNACRL------FSQLISGVHYIHSKGLVHRDLKLENLLLDKNENLV 190
Query: 143 LADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK-YYSTAVDIWSLGCIFAEMVTRRA 201
+ DFG F + Y APE+++ + Y + DIWS G I ++
Sbjct: 191 ITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPYEARKADIWSCGVILYAILAGYL 250
Query: 202 LF---PGDSEIDQLFRIFRTL-GTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDE 257
+ P + E + R++ + TP PDY P
Sbjct: 251 PWDDDPNNPEGSDIGRLYNYINSTP--------LKFPDYILPIP---------------- 286
Query: 258 DGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
R LL +ML DP KRI+ K H + +
Sbjct: 287 --RDLLRRMLVSDPKKRINLKQIKKHEWLK 314
>ref|NP_014876.1| (NC_001147) protein kinase; Kin4p [Saccharomyces cerevisiae]
Length = 800
Score = 79.3 bits (194), Expect = 7e-16
Identities = 78/295 (26%), Positives = 125/295 (41%), Gaps = 57/295 (19%)
Query: 10 IGEGTYGVVYKARNKLTG-----EVVALKKIRLDTETEGVPSTA--IREISLLKELNHPN 62
+GEG +G V K + + VA+K IR DT + REI+ LK L HPN
Sbjct: 52 LGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPN 111
Query: 63 IVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLF-QLLQ 113
I+ L +V+ + +V EF+ Q ++ ++SA LF QL+
Sbjct: 112 IIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACR----------LFAQLIS 161
Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173
G+ + H ++HRDLK +NLL++ + + DFG F + Y APE+
Sbjct: 162 GVNYMHYKGLVHRDLKLENLLLDKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPEL 221
Query: 174 LLGCK-YYSTAVDIWSLGCIFAEMVTRRALFPGDSEI---DQLFRIFRTL-GTPDEVVWP 228
++ K Y + D+WS G I M+ + D E D + R+++ + TP
Sbjct: 222 VVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIARLYKYITQTP------ 275
Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 283
P+Y P R LL ++L +P +RI+ + H
Sbjct: 276 --LKFPEYITPIP------------------RDLLRRILVPNPRRRINLQTIKRH 310
>ref|NP_011566.1| (NC_001139) Hypothetical ORF; Ygr052wp [Saccharomyces cerevisiae]
Length = 369
Score = 79.0 bits (193), Expect = 9e-16
Identities = 66/224 (29%), Positives = 98/224 (43%), Gaps = 27/224 (12%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPN 62
+ K+ I GT+ VYKA + VALK +E + +L N HPN
Sbjct: 2 YTKLRSIQSGTFSTVYKAWSTTHNRYVALKITPKYKTSEANMKNEYDVMKILSSCNPHPN 61
Query: 63 IVKLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPL------IKSYLFQLLQGL 115
I +LD ++ +V E+ DL F+D + G P ++ + QL +
Sbjct: 62 ICSMLDFYTDDSYYIMVLEYCECGDLYDFLDIAKSQGSPSSPSLIQIDMQKIIKQLCSAI 121
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175
+F HS + HRD+KP+N+L+ G IKLAD+G A P ++ ++ T YRAPE
Sbjct: 122 SFAHSLGIAHRDIKPENILLTINGDIKLADWG--HAIQSP-KSNDFQIGTDNYRAPETFS 178
Query: 176 G-----C-----------KYYSTAVDIWSLGCIFAEMVTRRALF 203
G C Y + D WSLG ++ LF
Sbjct: 179 GRVSNSCFKKNFDRSSAPLYNTYQADYWSLGATIFYLMFGDCLF 222
>ref|NP_009385.1| (NC_001133) contains serine/threonine protein kinase domain and shows
homology with the SNF1 serine/threonine protein kinase;
Fun31p [Saccharomyces cerevisiae]
Length = 1356
Score = 77.8 bits (190), Expect = 2e-15
Identities = 62/223 (27%), Positives = 108/223 (47%), Gaps = 23/223 (10%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALK-----KIRLDTETE----GVPSTAIREIS 53
+F ++K+GEG YG V +K +V +K +I +DT G + I+ ++
Sbjct: 1095 DFVSLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMA 1154
Query: 54 LLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-------DLKKFMDASALTGIPLPLIKS 106
L + H NI++LLD ++ Y+ + DL +F + +T LI
Sbjct: 1155 TLNKKPHENILRLLDFFEDDDYYYIETPVHGETGCIDLFDLIEFK--TNMTEFEAKLIFK 1212
Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTL 166
Q++ G+ H ++HRD+K +N++++++G +K+ DFG A V + V T+
Sbjct: 1213 ---QVVAGIKHLHDQGIVHRDIKDENVIVDSKGFVKIIDFGSAAY--VKSGPFDVFVGTI 1267
Query: 167 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209
Y APE+L G Y DIW++G + +V + F EI
Sbjct: 1268 DYAAPEVLGGNPYEGQPQDIWAIGILLYTVVFKENPFYNIDEI 1310
>ref|NP_011606.1| (NC_001139) kinase required for late nuclear division; Dbf2p
[Saccharomyces cerevisiae]
Length = 572
Score = 76.6 bits (187), Expect = 4e-15
Identities = 83/274 (30%), Positives = 114/274 (41%), Gaps = 66/274 (24%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD-----TETEGVPSTAIREISLLKE 57
+F+ + ++G+G YG VY AR K T EV ALK + ET+ V + E +L
Sbjct: 176 DFEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHV----LTERDILTT 231
Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKS-----YLFQL 111
+VKLL LYL EF+ D + + I +KS Y+ ++
Sbjct: 232 TRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLL-------INTRCLKSGHARFYISEM 284
Query: 112 LQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA-------RAFGVPVR------- 157
+ H HRDLKP+N LI+ +G IKL DFGLA R + +R
Sbjct: 285 FCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISNERIESMKIRLEKIKDL 344
Query: 158 -------------------------TYTHEVV-TLWYRAPEILLGCKYYSTAVDIWSLGC 191
Y + +V + Y A E+L G KY T VD WSLGC
Sbjct: 345 EFPAFTEKSIEDRRKMYNQLREKEINYANSMVGSPDYMALEVLEGKKYDFT-VDYWSLGC 403
Query: 192 IFAEMVTRRALFPGDS---EIDQLFRIFRTLGTP 222
+ E + F G S D L R +TL P
Sbjct: 404 MLFESLVGYTPFSGSSTNETYDNLRRWKQTLRRP 437
>ref|NP_010267.1| (NC_001136) Required for mitotic DNA synthesis but dispensable for
premeiotic DNA synthesis and spindle pole body
duplication; required for synaptonemal complexes,
meiotic recombination, spindle pole body separation and
spindles; Cdc7p [Saccharomyces c>
Length = 507
Score = 76.6 bits (187), Expect = 4e-15
Identities = 54/166 (32%), Positives = 87/166 (51%), Gaps = 28/166 (16%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEV---------------VALKKIRLDTETEGVPSTA 48
++ ++KIGEGT+ VYKA++ +TG++ VALKKI + + P
Sbjct: 33 YKLIDKIGEGTFSSVYKAKD-ITGKITKKFASHFWNYGSNYVALKKIYVTSS----PQRI 87
Query: 49 IREISLLKELNHPN-IVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKS 106
E++LL + + + L D +++ V + H++ + F +P+ IK
Sbjct: 88 YNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFY-----RDLPIKGIKK 142
Query: 107 YLFQLLQGLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARA 151
Y+++LL+ L F HS ++HRD+KP N L N E G L DFGLA A
Sbjct: 143 YIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEA 188
Score = 42.0 bits (97), Expect = 1e-04
Identities = 21/57 (36%), Positives = 31/57 (53%), Gaps = 1/57 (1%)
Query: 165 TLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLG 220
T +RAPE+L+ C ST +DIWS+G I ++ RR +F + D L + G
Sbjct: 281 TRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFG 337
Score = 27.3 bits (59), Expect = 2.9
Identities = 12/30 (40%), Positives = 17/30 (56%)
Query: 262 LLSQMLHYDPNKRISAKAALAHPFFQDVTK 291
+L Q DP KR SA+ L PFF ++ +
Sbjct: 445 VLEQCFEMDPQKRSSAEDLLKTPFFNELNE 474
>ref|NP_116624.1| (NC_001138) binds and phosphorylates Cdc28p; Cak1p [Saccharomyces
cerevisiae]
Length = 368
Score = 75.1 bits (183), Expect = 1e-14
Identities = 66/264 (25%), Positives = 114/264 (43%), Gaps = 63/264 (23%)
Query: 28 EVVALKKIRLDTETEGVPSTAIREISLLKELNHP--NIVKLLDVIHTENK-LYLVFEFLH 84
+ A+K + LD + P A E+S+L +L + +I+ LL+ T+N L L+F F
Sbjct: 26 DTYAIKCLALDFDIP--PHNAKFEVSILNKLGNKCKHILPLLESKATDNNDLLLLFPFEE 83
Query: 85 QDLKKFMDASA------------LTGIPLPLIK------------------SYLFQLLQG 114
+L +FM L +P++ S+ Q+++G
Sbjct: 84 MNLYEFMQMHYKRDRRKKNPYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEG 143
Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGA-----IKLADFGL-------ARAFGVPVRTYTHE 162
+AF H ++++HRD+KPQN+++ + + + DFG+ ++ P+ + +
Sbjct: 144 IAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTD 203
Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG----------------D 206
+ T Y+APE+L G K Y VD+WSL I ++ R G
Sbjct: 204 ISTGIYKAPEVLFGVKCYDGGVDVWSLLIIISQWFQRETSRMGHVPAMIDDGSDDMNSDG 263
Query: 207 SEIDQLFRIFRTLGTPDEVVWPGV 230
S+ + IF LG P W V
Sbjct: 264 SDFRLICSIFEKLGIPSIQKWEEV 287
>ref|NP_012593.1| (NC_001142) Putative serine/threonine protein kinase that enhances
spermine uptake; Ptk2p [Saccharomyces cerevisiae]
Length = 818
Score = 74.7 bits (182), Expect = 2e-14
Identities = 63/235 (26%), Positives = 98/235 (40%), Gaps = 28/235 (11%)
Query: 10 IGEGTYGVVYKARNKLTG-EVVALKKIRL--DTETEGVPSTAIREISLLKELNHP----- 61
IG G V K ++ +V ALKK+ + E +E + K L+H
Sbjct: 261 IGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITN 320
Query: 62 --NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
++K+ +T + E +DL + M+ + +P Q+ QG+ FCH
Sbjct: 321 TFYLLKVPTTTYTTRGWGFIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCH 380
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW-------YRAPE 172
+ + HRDLKP+N+LI+ EG KL DFG++ + V YT V T Y PE
Sbjct: 381 DNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPE 440
Query: 173 IL-----------LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216
++ Y A+D ++LG + M+ F D FR F
Sbjct: 441 VMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREF 495
>ref|NP_012370.1| (NC_001142) Protein kinase homolog, mutant is salt and pH
sensitive; Hal5p [Saccharomyces cerevisiae]
Length = 855
Score = 73.2 bits (178), Expect = 5e-14
Identities = 65/250 (26%), Positives = 104/250 (41%), Gaps = 43/250 (17%)
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT------------------GI 99
N PNI+K+LD++ N V EF DL + + ++ G
Sbjct: 599 NAPNILKILDLMEYSNSFVEVMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGS 658
Query: 100 PLPLIKSYLF--QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR 157
PL +++ F QLL G+ + H H + H DLKP+N+L G +K+ DFG + F
Sbjct: 659 PLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQPNGLLKICDFGTSSVFQTAWE 718
Query: 158 TYTH----EVVTLWYRAP-EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQ 211
+ H + + Y AP E + +Y VD WS G ++ MV + L+ E D
Sbjct: 719 KHVHFQSGAMGSEPYVAPEEFIRDAEYDPRLVDCWSCGIVYCTMVMGQYLWKIAIPEKDS 778
Query: 212 LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDP 271
LF+ F + + K + ++ V L+ + L + DP
Sbjct: 779 LFKSF----------------LSEIKDDGQFYLFEELRHVSSELNRLRKIALYRTFQVDP 822
Query: 272 NKRISAKAAL 281
KRI+ + L
Sbjct: 823 TKRITIEQLL 832
>ref|NP_010533.1| (NC_001136) Hypothetical ORF; Ydr247wp [Saccharomyces cerevisiae]
Length = 461
Score = 73.2 bits (178), Expect = 5e-14
Identities = 87/346 (25%), Positives = 134/346 (38%), Gaps = 102/346 (29%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI------------------------- 35
+ N+ +IGEG YG+VY+A + T A+K +
Sbjct: 9 INNYLITSQIGEGAYGLVYRALDIRTDRQYAIKAVVQSYGVSKEADMGNDKIHKNSVKLQ 68
Query: 36 ----RLDTETEGV---PSTAI-----------------REISL-LKELNHPNIVKLLDVI 70
+L E++ V PS + +EISL L+ +H NIV + +V+
Sbjct: 69 KKLAKLFKESKNVVRVPSIDLESIENMSEEDFKKLPHYKEISLHLRVHHHKNIVTIHEVL 128
Query: 71 HTENKLYLVFEFLHQDL-KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129
+ ++V ++ DL +D L L+K Q+ L +CH H + H D+K
Sbjct: 129 QSAVCTFIVMDYYPTDLFTSIVDNRHFVTNGL-LVKKVFLQICSALNYCHEHGIYHCDIK 187
Query: 130 PQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTL---WYRAPEIL------------ 174
P+NLL++TE + L DFGL+ TY V + +Y PE +
Sbjct: 188 PENLLLDTEDNVFLCDFGLS-----TTSTYIKPNVCIGSSYYMPPERISFDGRVSSSKSG 242
Query: 175 ---LGCKYYSTAVDIWSLGCIFAEMV-TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
LG S D+WSLG I + R D D + F T D
Sbjct: 243 GHKLGKVCPSCNGDLWSLGIILINLTCIRNPWLKADKTEDNTYYYF----TKD------- 291
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS 276
+ K + PL +D SLLS++L +P R+S
Sbjct: 292 ---------------PNILKQILPLSDDFYSLLSKILQVNPKNRMS 322
>ref|NP_015436.1| (NC_001148) kinase required for late nuclear division; Dbf20p
[Saccharomyces cerevisiae]
Length = 564
Score = 73.2 bits (178), Expect = 5e-14
Identities = 75/257 (29%), Positives = 107/257 (41%), Gaps = 63/257 (24%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD-----TETEGVPSTAIREISLLK 56
++FQ + ++G+G YG VY A+ K + E+ ALK + ET V + E +L
Sbjct: 167 KDFQILTQVGQGGYGQVYLAKKKDSDEICALKILNKKLLFKLNETNHV----LTERDILT 222
Query: 57 ELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKS-----YLFQ 110
+VKLL LYL EF+ D + + I ++KS Y+ +
Sbjct: 223 TTRSDWLVKLLYAFQDPESLYLAMEFVPGGDFRTLL-------INTRILKSGHARFYISE 275
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA-------RAFGVPVR------ 157
+ + H HRDLKP+N LI+ G IKL DFGLA R + +R
Sbjct: 276 MFCAVNALHELGYTHRDLKPENFLIDATGHIKLTDFGLAAGTVSNERIESMKIRLEEVKN 335
Query: 158 --------------------------TYTHEVV-TLWYRAPEILLGCKYYSTAVDIWSLG 190
Y + +V + Y A E+L G KY T VD WSLG
Sbjct: 336 LEFPAFTERSIEDRRKIYHNMRKTEINYANSMVGSPDYMALEVLEGKKYDFT-VDYWSLG 394
Query: 191 CIFAEMVTRRALFPGDS 207
C+ E + F G S
Sbjct: 395 CMLFESLVGYTPFSGSS 411
>ref|NP_009934.1| (NC_001135) Protein with similarity to Npr1p protein kinase; Sat4p
[Saccharomyces cerevisiae]
Length = 603
Score = 72.0 bits (175), Expect = 1e-13
Identities = 64/224 (28%), Positives = 100/224 (44%), Gaps = 22/224 (9%)
Query: 8 EKIGEGTYGVVYKARNKLTG--------EVVALK--KIRLDTETEGVPSTAIREISLLKE 57
E +G+G +GVV + K ++ A+K K R E E +
Sbjct: 320 EVLGKGAFGVVRICQKKNVSSQDGNKSEKLYAVKEFKRRTSESAEKYSKRLTSEFCISSS 379
Query: 58 LNHPNIVKLLDVIHTENKLYL-VFEFLHQ-DLKKFMDASALTGIPLPLIKSYLF--QLLQ 113
L+H NIV LD+ Y V E+ DL + A+ L +++ F QL++
Sbjct: 380 LHHTNIVTTLDLFQDAKGEYCEVMEYCAGGDLFTLVVAAG----KLEYMEADCFFKQLIR 435
Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTH----EVVTLWYR 169
G+ + H V HRDLKP+NLL+ +G +K+ DFG + F + H + Y
Sbjct: 436 GVVYMHEMGVCHRDLKPENLLLTHDGVLKITDFGNSECFKMAWEKNIHLSGGVCGSSPYI 495
Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLF 213
APE + ++ VDIW+ G I+ M T R L+ + D +
Sbjct: 496 APEEYIKEEFDPRPVDIWACGVIYMAMRTGRQLWSSAEKDDPFY 539
>ref|NP_014996.1| (NC_001147) Disp. for chr. pairing & chr. condensation seen by in
situ hybrid. Required for full double strand breaks,
normal length synaptonemal complexes, meiotic recomb. &
spore viability. mek1 is rescued by spo13 & in early
recomb. function; Mek1p >
Length = 497
Score = 70.9 bits (172), Expect = 2e-13
Identities = 78/304 (25%), Positives = 123/304 (39%), Gaps = 60/304 (19%)
Query: 10 IGEGTYGVVYKARNKLTG--------EVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+G GT+G V N E A+K I+L P+ +E +L L+HP
Sbjct: 168 VGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLK------PNKFDKEARILLRLDHP 221
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ--DLKKFM-DASALTGIPLPLIKSYLFQLLQGLAFC 118
NI+K+ N +F+ L DL ++ LT + +FQ+LQ L +
Sbjct: 222 NIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSMSETESLLIVFQILQALNYL 281
Query: 119 HSHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI-- 173
H ++HRDLK N+L+ T I LADFG+A+ V T Y APE+
Sbjct: 282 HDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGF 341
Query: 174 --------------LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTL 219
L + Y + D+WSLG I M+T + F GD
Sbjct: 342 RANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGD------------- 388
Query: 220 GTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA 279
G+ ++ ++K +W + ++ +S + +L D KR+++K
Sbjct: 389 GSERSIIQNAKIGKLNFK--LKQW---------DIVSDNAKSFVKDLLQTDVVKRLNSKQ 437
Query: 280 ALAH 283
L H
Sbjct: 438 GLKH 441
>ref|NP_012753.1| (NC_001143) Serine/threonine protein kinase of unknown function;
Kkq8p [Saccharomyces cerevisiae]
Length = 734
Score = 68.6 bits (166), Expect = 1e-12
Identities = 46/145 (31%), Positives = 69/145 (46%), Gaps = 8/145 (5%)
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFM-DASALTGIPLPL-IKSYLFQLLQGLAF 117
PNI+ + D++ + V EF DL + S L G PL ++ QLL G+ F
Sbjct: 504 PNILNVFDILEDSSSFIEVMEFCPAGDLYGMLVGKSKLKGRLHPLEADCFMKQLLHGVKF 563
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE----VVTLWYRAPEI 173
H H + H DLKP+N+L G +K+ DFG + F H + + Y APE
Sbjct: 564 MHDHGIAHCDLKPENILFYPHGLLKICDFGTSSVFQTAWERRVHAQKGIIGSEPYVAPEE 623
Query: 174 LLGCKYYS-TAVDIWSLGCIFAEMV 197
+ +YY +D WS G ++ M+
Sbjct: 624 FVDGEYYDPRLIDCWSCGVVYITMI 648
>ref|NP_014597.1| (NC_001147) Hypothetical ORF; Yol045wp [Saccharomyces cerevisiae]
Length = 1101
Score = 67.8 bits (164), Expect = 2e-12
Identities = 55/220 (25%), Positives = 103/220 (46%), Gaps = 17/220 (7%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALK-----KIRLDTETE----GVPSTAIREIS 53
+F ++ +GEG YG V + +V +K +I +DT G + I+ ++
Sbjct: 840 DFTILQVMGEGAYGKVNLCIHNREHYIVVIKMIFKERILVDTWVRDRKLGTIPSEIQIMA 899
Query: 54 LLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLI----KSYLF 109
L + + NI+KLLD ++ Y+ +H + +D + ++ K
Sbjct: 900 TLNKNSQENILKLLDFFEDDDYYYIETP-VHGETGS-IDLFDVIEFKKDMVEHEAKLVFK 957
Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR 169
Q++ + H ++HRD+K +N+++++ G +KL DFG A + + V T+ Y
Sbjct: 958 QVVASIKHLHDQGIVHRDIKDENVIVDSHGFVKLIDFGSAAY--IKSGPFDVFVGTMDYA 1015
Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209
APE+L G Y DIW+LG + ++ + + EI
Sbjct: 1016 APEVLGGSSYKGKPQDIWALGVLLYTIIYKENPYYNIDEI 1055
>ref|NP_010569.1| (NC_001136) Derepression of GCN4 expression; Gcn2p [Saccharomyces
cerevisiae]
Length = 1659
Score = 67.0 bits (162), Expect = 3e-12
Identities = 51/169 (30%), Positives = 84/169 (49%), Gaps = 39/169 (23%)
Query: 45 PSTAIREIS-LLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL 103
P TA+++ S L ++ + L D+IH+EN L+Q ++
Sbjct: 774 PMTAVKKKSTLFIQMEYCENRTLYDLIHSEN--------LNQQRDEYWR----------- 814
Query: 104 IKSYLF-QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR------------ 150
LF Q+L+ L++ HS ++HRDLKP N+ I+ +K+ DFGLA+
Sbjct: 815 ----LFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLD 870
Query: 151 AFGVPVRT--YTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197
+ +P + T + T Y A E+L G +Y+ +D++SLG IF EM+
Sbjct: 871 SQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI 919
Score = 49.7 bits (117), Expect = 6e-07
Identities = 26/63 (41%), Positives = 38/63 (60%), Gaps = 3/63 (4%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
+F+++ +G+G +G V KARN L A+KKIR TE ST + E+ LL LNH
Sbjct: 598 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR---HTEEKLSTILSEVMLLASLNHQY 654
Query: 63 IVK 65
+V+
Sbjct: 655 VVR 657
Score = 32.3 bits (72), Expect = 0.092
Identities = 48/207 (23%), Positives = 80/207 (38%), Gaps = 61/207 (29%)
Query: 99 IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT 158
+ L + ++ +LL+GL H ++H+ + + +++ +K ADFG + + T
Sbjct: 365 VNLATARIWMIRLLEGLEAIHKLGIVHKCINLETVIL-----VKDADFG-STIPKLVHST 418
Query: 159 YTHEVVTLWYR-----------------APEIL-LGCKYYSTAVDIWSLGCIFAEMVTRR 200
Y + V+ + R APE+L DIW LG +F ++++
Sbjct: 419 YGYTVLNMLSRYPNKNGSSVELSPSTWIAPELLKFNNAKPQRLTDIWQLGVLFIQIIS-- 476
Query: 201 ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGR 260
S+I F TP E + TSM DE
Sbjct: 477 -----GSDIVMNFE------TPQEFL--DSTSM----------------------DETLY 501
Query: 261 SLLSQMLHYDPNKRISAKAALAHPFFQ 287
LLS+ML+ DP KR+ L F +
Sbjct: 502 DLLSKMLNNDPKKRLGTLELLPMKFLR 528
>ref|NP_014238.1| (NC_001146) cell wall biosynthesis kinase; Cbk1p [Saccharomyces
cerevisiae]
Length = 756
Score = 66.2 bits (160), Expect = 6e-12
Identities = 46/154 (29%), Positives = 77/154 (49%), Gaps = 4/154 (2%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59
+E+F V+ IG+G +G V + K TG++ A+K + + + + + E +L +
Sbjct: 349 LEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSD 408
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
P +V L LYL+ EFL DL + L + + Y+ + + +
Sbjct: 409 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQL--FTEDVTRFYMAECILAIETI 466
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF 152
H +HRD+KP N+LI+ G IKL+DFGL+ F
Sbjct: 467 HKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGF 500
>ref|NP_012348.1| (NC_001142) Protein kinase that inhibits G2/M transition.
S.
pombe wee1+ homolog; Swe1p [Saccharomyces cerevisiae]
Length = 819
Score = 65.5 bits (158), Expect = 1e-11
Identities = 60/215 (27%), Positives = 99/215 (45%), Gaps = 18/215 (8%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
E F V IG+G + VY+ T + A+K I+ + + EI +L E+ +
Sbjct: 442 EKFTNVHSIGKGQFSTVYQVTFAQTNKKYAIKAIKPNKYNS--LKRILLEIKILNEVTNQ 499
Query: 62 NIVK------LLDVIHT---ENKLYLVFEFLHQ-DLKKFMDASALTG---IPLPLIKSYL 108
+ ++D I + +N Y++ E +L F+ + + I +
Sbjct: 500 ITMDQEGKEYIIDYISSWKFQNSYYIMTELCENGNLDGFLQEQVIAKKKRLEDWRIWKII 559
Query: 109 FQLLQGLAFCH-SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW 167
+L L F H S ++H DLKP N++I EG +KL DFG+A + +++ +E
Sbjct: 560 VELSLALRFIHDSCHIVHLDLKPANVMITFEGNLKLGDFGMATHLPLEDKSFENE-GDRE 618
Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRAL 202
Y APEI+ C Y A DI+SLG + E+ L
Sbjct: 619 YIAPEIISDCTYDYKA-DIFSLGLMIVEIAANVVL 652
>ref|NP_011357.1| (NC_001139) Serine/threonine protein kinase; Rck1p [Saccharomyces
cerevisiae]
Length = 512
Score = 65.1 bits (157), Expect = 1e-11
Identities = 81/329 (24%), Positives = 126/329 (37%), Gaps = 77/329 (23%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEV--VALKKIRLDTETEGVPSTAIRE------- 51
+ N++ + KIGEG + V+KA T + VA+K I +G+ S AI +
Sbjct: 118 LHNYKLLNKIGEGAFSRVFKAVGINTDDQAPVAIKAII----KKGISSDAILKGNDRIQG 173
Query: 52 -----------ISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIP 100
I L N+P+ K + + N YLV E + + F LT
Sbjct: 174 SSRKKVLNEVAIHKLVSKNNPHCTKFIAFQESANYYYLVTELVTGG-EIFDRIVQLTCFS 232
Query: 101 LPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT----------------------- 137
L + + Q+ + H ++HRD+KP+NLL
Sbjct: 233 EDLARHVITQVAIAIKHMHYMGIVHRDVKPENLLFEPIPFYGLDGDMQKEDEFTLGVGGG 292
Query: 138 -EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEM 196
G +KL DFGLA+ + T T+ Y A E+ K YS VD+WS+GC+ +
Sbjct: 293 GIGLVKLMDFGLAKK--LRNNTAKTPCGTIEYVASEVFTS-KRYSMKVDMWSIGCVLFTL 349
Query: 197 VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD 256
+ F +E L +I S DY+ P W +
Sbjct: 350 LCGYPPFYEKNEKTLLKKI----------------SRGDYEFLAPWWDN---------IS 384
Query: 257 EDGRSLLSQMLHYDPNKRISAKAALAHPF 285
++ ++ +L DPNKR L P+
Sbjct: 385 SGAKNAVTHLLEVDPNKRYDIDDFLNDPW 413
>ref|NP_012723.1| (NC_001143) Putative serine/threonine protein kinase; Ptk1p
[Saccharomyces cerevisiae]
Length = 399
Score = 61.6 bits (148), Expect = 1e-10
Identities = 46/150 (30%), Positives = 73/150 (48%), Gaps = 10/150 (6%)
Query: 10 IGEGTYGVVYKARNKLTG-EVVALKKIRL--DTETEGVPSTAIREISLLKELNHPN---- 62
IG G V K R+K +V ALKK+ + + E + A +E + K+L+H
Sbjct: 202 IGWGGSCEVRKIRSKYRKKDVFALKKLNMIYNETPEKFYNAAPKEFIIAKQLSHHVHITN 261
Query: 63 ---IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
+VK+ ++T V E +DL + S + L Q+ G+ FCH
Sbjct: 262 TFLLVKVPTTVYTTRGWGFVMELGLRDLFAMIQKSGWRHVALAEKFCIFKQVACGVKFCH 321
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLA 149
+ HRDLKP+N+L++ +G KL DFG++
Sbjct: 322 DQGIAHRDLKPENVLLSPDGVCKLTDFGIS 351
>ref|NP_015299.1| (NC_001148) multicopy suppressor of snf3 and grr1 mutants; Sks1p
[Saccharomyces cerevisiae]
Length = 502
Score = 60.1 bits (144), Expect = 4e-10
Identities = 57/196 (29%), Positives = 83/196 (42%), Gaps = 20/196 (10%)
Query: 22 RNKLTGEVVALKKIRLDTETEGVPSTAIREISL-LKELNHPNIVKLLDVIHTENKLYLVF 80
+ KL V L I TE E REI+ L+ +H NIVK+ V+ + ++V
Sbjct: 80 QKKLFLPSVDLDSILQLTENELNRLPHYREIAFQLRVQSHGNIVKIHQVLESSIATFIVM 139
Query: 81 EFLHQDL-KKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEG 139
++ +DL +D + LIK QL L CH + H D+KP+N+L++
Sbjct: 140 DYYDRDLFTSIVDDKHFVNHGI-LIKKVFLQLCSALDHCHRLGIYHCDIKPENVLLDRND 198
Query: 140 AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST---------------AV 184
L DFGL+ V + +Y APE +L C +T
Sbjct: 199 NAYLCDFGLSTKSKYLAPNVC--VGSSYYMAPERILYCLNTTTNGIHVDECCSSLPTDTG 256
Query: 185 DIWSLGCIFAEMVTRR 200
DIWSLG I + R
Sbjct: 257 DIWSLGIILINLTCIR 272
>ref|NP_014019.1| (NC_001145) Hypothetical ORF; Ymr291wp [Saccharomyces cerevisiae]
Length = 586
Score = 57.8 bits (138), Expect = 2e-09
Identities = 62/240 (25%), Positives = 100/240 (40%), Gaps = 60/240 (25%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN---------- 59
+G+G + VV + N T ++ A+K I+ T + RE LL+ ++
Sbjct: 45 LGDGNFSVVKECMNIHTKDLYAMKLIKKQTVKNKIQLIQ-REFDLLRSISEKIRDMEKKN 103
Query: 60 ---------HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLF 109
H +I++L D T + + L+ + + DL + + + + + SY
Sbjct: 104 EHSLDIFEGHHHILQLFDYFETADNIVLITQLCQKGDLYEKIVENQCLDLETQ-VTSYCA 162
Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLI---------NTEGA-------------IKLADFG 147
L+ L F HS ++HRDLK +N+L N +G + LADFG
Sbjct: 163 CLVSVLEFLHSQGIVHRDLKAENVLFRLRVNENEKNLQGEHHGDFKYDLLAHDLVLADFG 222
Query: 148 LARAFGV-PVRTYTHEVVTLWYRAPEILLGCK--------------YYSTAVDIWSLGCI 192
LA + V + V T+ Y APEI + CK Y VDIW+LG +
Sbjct: 223 LAAEYNTSKVNSLKEFVGTISYIAPEI-VKCKGVGEMTPDQVGKLDKYGCPVDIWALGVL 281
>ref|NP_013943.1| (NC_001145) SRPK1-like Kinase in Yeast (SRPK1 is a human serine
kinase that specifically phosphoryates arginine-serine
rich domains found in the SR family of splicing
factors.); Sky1p [Saccharomyces cerevisiae]
Length = 742
Score = 57.4 bits (137), Expect = 3e-09
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 26/160 (16%)
Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN---- 62
V K+G G + V+ A++ + VA+K +R D + A EI LL+ +N +
Sbjct: 161 VRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGD---KVYTEAAEDEIKLLQRVNDADNTKE 217
Query: 63 -------IVKLLDVIHTENK------LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109
I+KLLD H +K + +VFE L ++L + GIPL +K
Sbjct: 218 DSMGANHILKLLD--HFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISK 275
Query: 110 QLLQGLAFCHSH-RVLHRDLKPQNLLI---NTEGAIKLAD 145
QLL GL + H ++H D+KP+N+L+ + EG +++ +
Sbjct: 276 QLLLGLDYMHRRCGIIHTDIKPENVLMEIGDVEGIVQMVE 315
Score = 55.5 bits (132), Expect = 1e-08
Identities = 50/178 (28%), Positives = 74/178 (41%), Gaps = 28/178 (15%)
Query: 130 PQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189
P+NL+ IK+AD G A + YT+ + T YR+PE+LLG + DIWS
Sbjct: 540 PENLI-----QIKIADLGNACWYD---EHYTNSIQTREYRSPEVLLGAP-WGCGADIWST 590
Query: 190 GCIFAEMVTRRALFPGD------SEIDQLFRIFRTLG-TPDEVVWPGVTSMPDYK----- 237
C+ E++T LF D + D + +I LG P ++ G + +
Sbjct: 591 ACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLL 650
Query: 238 ---PSFPKWARQDFSKVVPPLDEDG----RSLLSQMLHYDPNKRISAKAALAHPFFQD 288
W +D +D LS ML DP KR A + HP+ +D
Sbjct: 651 RNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 708
>ref|NP_011950.1| (NC_001140) Serine/threonine kinase similar to casein kinase II and
other serine/threonine protein kinases; Ksp1p
[Saccharomyces cerevisiae]
Length = 1029
Score = 57.4 bits (137), Expect = 3e-09
Identities = 49/180 (27%), Positives = 87/180 (48%), Gaps = 19/180 (10%)
Query: 48 AIREISLLKELN-HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIK 105
A+ E+ + ++ H NI LLD + Y++ E+ DL + + A A+ I
Sbjct: 131 AMYEVDIQTKIGRHQNIAALLDFFDS----YIIMEYCSGGDLYEAIKADAVPK-KTKSIT 185
Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVV 164
+ Q++ + + H+ + HRD+KP+N+LI+ + IKL D+GLA + V
Sbjct: 186 HIITQIMDAIEYVHNKGIYHRDIKPENILISGIDWTIKLTDWGLAT---TDKTSMDRNVG 242
Query: 165 TLWYRAPEIL---LGCK-----YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIF 216
+ Y +PE+ L K Y VD+W++G +F +V + F ++ D+ F F
Sbjct: 243 SERYMSPELFDSNLDIKERKEPYDCAKVDLWAMGIVFLNIVFHKNPFSIANQSDKSFCYF 302
Score = 29.6 bits (65), Expect = 0.59
Identities = 14/32 (43%), Positives = 21/32 (64%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKI 35
+QK+E I EG+YG V A++ +VA+K I
Sbjct: 18 YQKIEDISEGSYGYVSLAKDVREKRLVAVKYI 49
>ref|NP_012003.1| (NC_001140) membrane-bound casein kinase I homolog; Yck1p
[Saccharomyces cerevisiae]
Length = 538
Score = 52.8 bits (125), Expect = 7e-08
Identities = 51/179 (28%), Positives = 78/179 (43%), Gaps = 16/179 (8%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HPNIVKL 66
+KIGEG++GV+++ N + G VA+K TE + E K LN PNI
Sbjct: 73 KKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRD----EYKTYKILNGTPNIPYA 128
Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126
LV + L L+ D + + Q++ + H+H +++R
Sbjct: 129 YYFGQEGLHNILVIDLLGPSLEDLFDWCG-RKFSVKTVVQVAVQMITLIEDLHAHDLIYR 187
Query: 127 DLKPQNLLINTEGA-----IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
D+KP N LI G I L DFG+A+ + P +T H + YR + L G Y
Sbjct: 188 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDP-KTKQH----IPYREKKSLSGTARY 241
>ref|NP_012750.1| (NC_001143) Hypothetical ORF; Ykl171wp [Saccharomyces cerevisiae]
Length = 928
Score = 48.9 bits (115), Expect = 9e-07
Identities = 42/157 (26%), Positives = 73/157 (45%), Gaps = 15/157 (9%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
IG G +G++ + + TG +K ++ + + +RE+++ + L H I+ LLD
Sbjct: 455 IGFGAWGIIRECFDIETGVGRVIKIVKFKGH-QNIKKHVLREVAIWRTLKHNRILPLLDW 513
Query: 70 IHTEN-KLYLVFEFLHQ----DLKKFMDASALTGIPLP----LIKSYLFQLLQGLAFCHS 120
+N +Y + E ++ DL D + IP L QLL L + HS
Sbjct: 514 KLDDNYAMYCLTERINDGTLYDLVISWDEFKRSKIPFAERCRLTIFLSLQLLSALKYMHS 573
Query: 121 HRVLHRDLKPQNLLINTEG-----AIKLADFGLARAF 152
++H D+K +N L+ EG + L DFG++ F
Sbjct: 574 KTIVHGDIKLENCLLQKEGKKSDWKVFLCDFGMSCHF 610
>ref|NP_009615.1| (NC_001134) Ark-family kinase-like protein. This protein is the
third member (After Ark1p and Prk1p) of the Ark-family
kinases in S. cerevisiae.; Akl1p [Saccharomyces
cerevisiae]
Length = 1108
Score = 48.1 bits (113), Expect = 2e-06
Identities = 50/195 (25%), Positives = 93/195 (47%), Gaps = 28/195 (14%)
Query: 27 GEVVALKKIRLDTETEGVPSTAIREISLLKELNH-PNIVKLLDVIHTENK-------LYL 78
G+V LK++ + E G+ E+ ++K+L PNIV+ D + + + L
Sbjct: 72 GDVACLKRVLVQDEN-GLNEMR-NEVEVMKKLKGAPNIVQYFDSNASRRRDGVQGFEVLL 129
Query: 79 VFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV--LHRDLKPQNLLI 135
+ E ++ L +M+ T + I ++ + ++ H V +HRD+K +N+L+
Sbjct: 130 LMELCPNKSLLDYMNQRLSTKLTEAEIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLV 189
Query: 136 NTEGAIKLADFGLARAFGVPVRTYTHEVVTL-----------WYRAPEI--LLGCKYYST 182
+ + KLADFG + + P+ T TH+ + L YR+PE+ L C +
Sbjct: 190 DAKNNFKLADFG-STSTCFPIVT-THQDIALLTQNIYVHTTPQYRSPEMIDLYRCLPINE 247
Query: 183 AVDIWSLGCIFAEMV 197
DIW+LG +++
Sbjct: 248 KSDIWALGVFLYKLL 262
Database: Completed Saccharomyces cerevisiae
Posted date: Mar 6, 2002 1:29 AM
Number of letters in database: 2,967,424
Number of sequences in database: 6306
Lambda K H
0.323 0.140 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,746,587
Number of Sequences: 6306
Number of extensions: 74319
Number of successful extensions: 559
Number of sequences better than 10.0: 120
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 154
Number of HSP's gapped (non-prelim): 166
length of query: 298
length of database: 2,967,424
effective HSP length: 90
effective length of query: 208
effective length of database: 2,399,884
effective search space: 499175872
effective search space used: 499175872
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 55 (25.8 bits)
