LOCUS CDK5_MOUSE 292 aa linear ROD 16-OCT-2001
DEFINITION Cell division protein kinase 5 (TAU protein kinase II catalytic
subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase
PSSALRE) (CRK6).
ACCESSION P49615
PID g1345717
VERSION P49615 GI:1345717
DBSOURCE swissprot: locus CDK5_MOUSE, accession P49615;
class: standard.
created: Feb 1, 1996.
sequence updated: Feb 1, 1996.
annotation updated: Oct 16, 2001.
xrefs: gi: gi: 577635, gi: gi: 577636, gi: gi: 50558, gi: gi:
547568, gi: gi: 1839377
xrefs (non-sequence databases): HSSP P24941, MGD MGI:101765,
InterPro IPR000719, InterPro IPR002290, Pfam PF00069, SMART
SM00220, PROSITE PS00107, PROSITE PS00108, PROSITE PS50011
KEYWORDS Transferase; Serine/threonine-protein kinase; ATP-binding; Cell
cycle; Cell division; Phosphorylation.
SOURCE house mouse.
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
REFERENCE 1 (residues 1 to 292)
AUTHORS Ino,H., Ishizuka,T., Chiba,T. and Tatibana,M.
TITLE Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein
kinase, in the mature and developing mouse central and peripheral
nervous systems
JOURNAL Brain Res. 661 (1-2), 196-206 (1994)
MEDLINE 95135945
REMARK SEQUENCE FROM N.A.
TISSUE=Brain
REFERENCE 2 (residues 1 to 292)
AUTHORS Ershler,M., Nagorskaya,T.V., Visser,J.W. and Belyavsky,A.V.
TITLE Novel CDC2-related protein kinases produced in murine hematopoietic
stem cells
JOURNAL Gene 124 (2), 305-306 (1993)
MEDLINE 93185941
REMARK SEQUENCE OF 130-165 FROM N.A.
STRAIN=CBA; TISSUE=Bone marrow
REFERENCE 3 (residues 1 to 292)
AUTHORS Ohshima,T., Nagle,J.W., Pant,H.C., Joshi,J.B., Kozak,C.A.,
Brady,R.O. and Kulkarni,A.B.
TITLE Molecular cloning and chromosomal mapping of the mouse
cyclin-dependent kinase 5 gene
JOURNAL Genomics 28 (3), 585-588 (1995)
MEDLINE 96039276
REMARK SEQUENCE OF 1-12 FROM N.A.
COMMENT -------------------------------------------------------------------
This SWISS-PROT entry is copyright. It is produced through a
collaboration between the Swiss Institute of Bioinformatics and
the EMBL outstation - the European Bioinformatics Institute.
The original entry is available from http://www.expasy.ch/sprot
and http://www.ebi.ac.uk/sprot
------------------------------------------------------------------.
[FUNCTION] PROBABLY INVOLVED IN THE CONTROL OF THE CELL CYCLE.
INTERACTS WITH D1 AND D3-TYPE G1 CYCLINS. CAN PHOSPHORYLATE HISTONE
H1, TAU, MAP2 AND NF-H AND NF-M. ALSO INTERACTS WITH P35 WHICH
ACTIVATES THE KINASE.
[SUBUNIT] HETERODIMER OF A CATALYTIC SUBUNIT AND A REGULATORY
SUBUNIT (P35).
[TISSUE SPECIFICITY] SPECIFICALLY EXPRESSED IN POST-MITOTIC
NEURONS.
[SIMILARITY] BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
CDC2/CDKX SUBFAMILY.
FEATURES Location/Qualifiers
source 1..292
/organism="Mus musculus"
/db_xref="taxon:10090"
1..292
Protein 1..292
/product="Cell division protein kinase 5"
/EC_number="2.7.1.-"
Region 4..286
/region_name="Domain"
/note="PROTEIN KINASE."
Site 10..18
/site_type="np-binding"
/note="ATP (BY SIMILARITY)."
Site 14
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
Site 15
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
Site 33
/site_type="binding"
/note="ATP (BY SIMILARITY)."
Site 126
/site_type="active"
/note="BY SIMILARITY."
Site 159
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
ORIGIN
1 mqkyekleki gegtygtvfk aknretheiv alkrvrlddd degvpssalr eicllkelkh
61 knivrlhdvl hsdkkltlvf efcdqdlkky fdscngdldp eivksflfql lkglgfchsr
121 nvlhrdlkpq nllinrngel kladfglara fgipvrcysa evvtlwyrpp dvlfgaklys
181 tsidmwsagc ifaelanagr plfpgndvdd qlkrifrllg tpteeqwpam tklpdykpyp
241 mypattslvn vvpklnatgr dllqnllkcn pvqrisaeea lqhpyfsdfc pp
//
Revised: October 24, 2001.
