-
LOCUS CDK2_MOUSE 346 aa linear ROD 20-AUG-2001
DEFINITION CELL DIVISION PROTEIN KINASE 2.
ACCESSION P97377
PID g8039782
VERSION P97377 GI:8039782
DBSOURCE swissprot: locus CDK2_MOUSE, accession P97377;
class: standard.
extra accessions:O55105,created: Jul 15, 1999.
sequence updated: May 30, 2000.
annotation updated: Aug 20, 2001.
xrefs: gi: gi: 1695879, gi: gi: 1695880, gi: gi: 2832436, gi: gi:
2832437, gi: gi: 2842420, gi: gi: 2842421, gi: gi: 2842422
xrefs (non-sequence databases): MGD MGI:104772, InterPro IPR000719,
InterPro IPR002290, Pfam PF00069, PROSITE PS00108, PROSITE PS00107,
PROSITE PS50011
KEYWORDS Transferase; Serine/threonine-protein kinase; ATP-binding; Cell
cycle; Cell division; Mitosis; Phosphorylation; Alternative
splicing.
SOURCE house mouse.
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
REFERENCE 1 (residues 1 to 346)
AUTHORS Jun,D., Lee,Y.H., Park,H.K. and Kim,Y.H.
TITLE Direct Submission
JOURNAL Submitted (??-JUL-1996)
REMARK SEQUENCE FROM N.A. (ISOFORM CDK2-ALPHA).
STRAIN=C57BL/6
REFERENCE 2 (residues 1 to 346)
AUTHORS Ellenrieder,C., Bartosch,B., Lee,G.Y., Murphy,M., Sweeney,C.,
Hergersberg,M., Hunt,T., Carrington,M. and Jaussi,R.
TITLE Direct Submission
JOURNAL Submitted (??-JAN-1998)
REMARK SEQUENCE FROM N.A., AND ALTERNATIVE SPLICING.
COMMENT On May 23, 2000 this sequence version replaced gi:5921710.
-------------------------------------------------------------------
This SWISS-PROT entry is copyright. It is produced through a
collaboration between the Swiss Institute of Bioinformatics and
the EMBL outstation - the European Bioinformatics Institute.
The original entry is available from http://www.expasy.ch/sprot
and http://www.ebi.ac.uk/sprot
------------------------------------------------------------------.
[FUNCTION] PROBABLY INVOLVED IN THE CONTROL OF THE CELL CYCLE.
INTERACTS WITH CYCLINS A, D, OR E. ACTIVITY OF CDK2 IS MAXIMAL
DURING S PHASE AND G2.
[ENZYME REGULATION] PHOSPHORYLATION AT THR-14 OR TYR-15 INACTIVATES
THE ENZYME, WHILE PHOSPHORYLATION AT THR-160 ACTIVATES IT (BY
SIMILARITY).
[ALTERNATIVE PRODUCTS] 2 ISOFORMS; CDK2-ALPHA AND CDK2-BETA (SHOWN
HERE); ARE PRODUCED BY ALTERNATIVE SPLICING.
[SIMILARITY] BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
CDC2/CDKX SUBFAMILY.
FEATURES Location/Qualifiers
source 1..346
/organism="Mus musculus"
/db_xref="taxon:10090"
1..346
Protein 1..346
/product="CELL DIVISION PROTEIN KINASE 2"
/EC_number="2.7.1.-"
Region 4..334
/region_name="Domain"
/note="PROTEIN KINASE."
Site 10..18
/site_type="np-binding"
/note="ATP (BY SIMILARITY)."
Site 14
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
Site 15
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
Site 33
/site_type="binding"
/note="ATP (BY SIMILARITY)."
Site 127
/site_type="active"
/note="BY SIMILARITY."
Site 160
/site_type="phosphorylation"
/note="(BY CAK) (BY SIMILARITY)."
Region 197..244
/region_name="Splicing variant"
/note="MISSING (IN CDK2-ALPHA)."
ORIGIN
1 menfqkveki gegtygvvyk aknkltgevv alkkirldte tegvpstair eisllkelnh
61 pnivklldvi htenklylvf eflhqdlkkf mdasaltgip lpliksylfq llqglafchs
121 hrvlhrdlkp qnllinaegs ikladfglar afgvpvrtyt hevvtlwyra peillgckyy
181 stavdiwslg cifaemhlvc tqhhakccge hrrngrhslc plcsylevaa sqgggmtavs
241 aphpvtrral fpgdseidql frifrtlgtp devvwpgvts mpdykpsfpk warqdfskvv
301 ppldedgrsl lsqmlhydpn krisakaala hpffqdvtkp vphlrl
//
Revised: October 24, 2001.
