Score E
Sequences producing significant alignments: (bits) Value
ref|NP_058036.1| (NM_016756) cyclin-dependent kinase 2 [Mus... 600 e-173
ref|NP_031685.1| (NM_007659) cell division cycle 2 homolog ... 389 e-109
ref|NP_031694.1| (NM_007668) cyclin-dependent kinase 5 [Mus... 350 2e-97
ref|NP_035179.1| (NM_011049) PCTAIRE-motif protein kinase 1... 315 7e-87
ref|NP_032821.1| (NM_008795) PCTAIRE-motif protein kinase 3... 314 2e-86
ref|NP_035204.1| (NM_011074) PFTAIRE protein kinase 1 [Mus ... 285 6e-78
ref|NP_031687.1| (NM_007661) cell division cycle 2 homolog ... 269 4e-73
ref|NP_034003.1| (NM_009873) cyclin-dependent kinase 6 [Mus... 267 2e-72
ref|NP_031686.1| (NM_007660) cell division cycle 2 homolog ... 263 2e-71
ref|NP_444410.1| (NM_053180) CDK-related protein kinase PNQ... 244 2e-65
ref|NP_034000.1| (NM_009870) cyclin-dependent kinase 4; p34... 241 1e-64
ref|NP_058608.1| (NM_016912) cyclin-dependent kinase-like 2... 229 7e-61
ref|NP_032573.1| (NM_008547) male germ cell-associated kina... 218 9e-58
ref|NP_064371.1| (NM_019987) intestinal cell kinase [Mus mu... 213 3e-56
ref|NP_570930.1| (NM_130860) cyclin-dependent kinase 9 [Mus... 209 7e-55
ref|NP_035971.1| (NM_011841) mitogen-activated protein kina... 208 9e-55
ref|NP_036080.1| (NM_011950) mitogen activated protein kina... 199 4e-52
ref|NP_038899.1| (NM_013871) stress activated protein kinas... 196 6e-51
ref|NP_036081.1| (NM_011951) mitogen activated protein kina... 187 2e-48
ref|NP_036079.1| (NM_011949) mitogen activated protein kina... 186 5e-48
ref|NP_032728.1| (NM_008702) nemo like kinase [Mus musculus] 183 3e-47
ref|NP_035291.2| (NM_011161) protein kinase, mitogen activa... 180 3e-46
ref|NP_033184.1| (NM_009158) mitogen activated protein kina... 173 3e-44
ref|NP_062801.1| (NM_019827) glycogen synthase kinase 3 bet... 170 4e-43
ref|NP_058657.1| (NM_016961) mitogen activated protein kina... 169 5e-43
ref|NP_057909.1| (NM_016700) mitogen activated protein kina... 169 8e-43
ref|NP_056621.1| (NM_015806) mitogen-activated protein kina... 160 2e-40
ref|NP_036103.1| (NM_011973) renal tumor antigen; MAPK/MAK/... 160 3e-40
ref|NP_034104.1| (NM_009974) casein kinase II, alpha 2, pol... 140 4e-34
ref|NP_031814.1| (NM_007788) casein kinase II, alpha 1 rela... 136 6e-33
ref|NP_031813.1| (NM_007787) casein kinase II, alpha 1 poly... 135 8e-33
ref|NP_034222.1| (NM_010092) dual-specificity tyrosine-(Y)-... 132 1e-31
ref|NP_067619.1| (NM_021606) NIMA-related expressed kinase ... 129 9e-31
ref|NP_067618.1| (NM_021605) NIMA (never in mitosis gene a)... 125 8e-30
ref|NP_067491.1| (NM_021516) MAP/microtubule affinity-regul... 120 3e-28
ref|NP_032804.1| (NM_008778) p21 (CDKN1A)-activated kinase ... 120 3e-28
ref|NP_073712.1| (NM_022801) MAP/microtubule affinity-regul... 120 3e-28
ref|NP_034961.1| (NM_010831) myocardial SNF1-like kinase [M... 119 6e-28
ref|NP_036078.1| (NM_011948) mitogen activated protein kina... 118 1e-27
ref|NP_033314.1| (NM_009288) serine/threonine kinase 10 [Mu... 117 4e-27
ref|NP_062609.1| (NM_019635) serine/threonine kinase 3 (Ste... 116 6e-27
ref|NP_035165.1| (NM_011035) p21 (CDKN1A)-activated kinase ... 115 8e-27
ref|NP_067395.1| (NM_021420) serine/threonine kinase 4; STE... 115 8e-27
ref|NP_034562.1| (NM_010432) homeodomain interacting protei... 114 2e-26
ref|NP_031954.1| (NM_007928) ELKL motif kinase [Mus musculus] 114 2e-26
ref|NP_034563.1| (NM_010433) homeodomain interacting protei... 114 3e-26
ref|NP_035622.1| (NM_011492) serine/threonine kinase 11 [Mu... 113 4e-26
ref|NP_033315.1| (NM_009289) serine/threonine kinase 2; Ste... 112 9e-26
ref|NP_032882.1| (NM_008856) protein kinase C, eta [Mus mus... 112 9e-26
ref|NP_057902.1| (NM_016693) mitogen-activated protein kina... 112 1e-25
ref|NP_032884.1| (NM_008858) protein kinase C, mu [Mus musc... 110 3e-25
ref|NP_034564.1| (NM_010434) homeodomain interacting protei... 110 3e-25
ref|NP_065597.1| (NM_020572) serine/threonine kinase 13 (au... 109 6e-25
ref|NP_034920.1| (NM_010790) maternal embryonic leucine zip... 109 6e-25
ref|NP_035022.1| (NM_010892) NIMA - related expressed kinas... 108 1e-24
ref|NP_035978.1| (NM_011848) NIMA-related expressed kinase ... 107 4e-24
ref|NP_032667.1| (NM_008641) microtubule associated testis ... 106 5e-24
ref|NP_032953.1| (NM_008927) mitogen activated protein kina... 104 2e-23
ref|NP_035293.1| (NM_011163) eukaryotic translation initiat... 104 2e-23
ref|NP_032885.1| (NM_008859) protein kinase C, theta [Mus m... 103 4e-23
ref|NP_033936.1| (NM_009806) calcium/calmodulin-dependent s... 103 4e-23
ref|NP_035233.1| (NM_011103) protein kinase C, delta; prote... 102 7e-23
ref|NP_075627.1| (NM_023138) mitogen activated protein kina... 102 9e-23
ref|NP_035915.1| (NM_011785) thymoma viral proto-oncogene 3... 102 1e-22
ref|NP_061371.1| (NM_018883) calcium/calmodulin-dependent p... 101 2e-22
ref|NP_035234.1| (NM_011104) protein kinase C, epsilon [Mus... 101 2e-22
ref|NP_035429.1| (NM_011299) ribosomal protein S6 kinase, 9... 101 2e-22
ref|NP_067460.1| (NM_021485) ribosomal protein S6 kinase, 7... 100 4e-22
ref|NP_056570.1| (NM_015755) hormonally upregulated Neu-ass... 100 4e-22
ref|NP_031621.1| (NM_007595) calcium/calmodulin-dependent p... 100 5e-22
ref|NP_033032.1| (NM_009006) mitogen activated protein kina... 100 6e-22
ref|NP_067512.1| (NM_021537) serine/threonine kinase 25 (ye... 99 8e-22
ref|NP_031717.1| (NM_007691) checkpoint kinase 1 homolog (S... 99 8e-22
ref|NP_031738.1| (NM_007712) CDC-like kinase 2 [Mus musculus] 99 1e-21
ref|NP_076302.1| (NM_023813) calcium/calmodulin-dependent p... 99 1e-21
ref|NP_033495.1| (NM_009469) Unc-51 like kinase 1 (C. elega... 98 2e-21
ref|NP_038909.1| (NM_013881) Unc-51 like kinase 2 (C. elega... 97 3e-21
ref|NP_034848.1| (NM_010718) LIM motif-containing protein k... 97 5e-21
ref|NP_033923.1| (NM_009793) calcium/calmodulin-dependent p... 97 5e-21
ref|NP_032606.1| (NM_008580) mitogen activated protein kina... 96 7e-21
ref|NP_035209.1| (NM_011079) phosphorylase kinase gamma [Mu... 96 7e-21
ref|NP_114393.1| (NM_032004) serine/threonine protein kinas... 96 9e-21
ref|NP_034847.1| (NM_010717) LIM-domain containing, protein... 96 9e-21
ref|NP_035979.1| (NM_011849) NIMA-related expressed kinase ... 95 1e-20
ref|NP_064362.1| (NM_019978) double cortin and calcium/calm... 94 3e-20
ref|NP_035970.1| (NM_011840) mitogen activated protein kina... 94 3e-20
ref|NP_057922.1| (NM_016713) mitogen-activated protein kina... 94 4e-20
ref|NP_064329.1| (NM_019945) syntrophin associated serine/t... 94 4e-20
ref|NP_573483.1| (NM_133220) serine/threonine protein kinas... 94 4e-20
ref|NP_036170.1| (NM_012040) pregnancy upregulated non-ubiq... 92 1e-19
ref|NP_031460.1| (NM_007434) thymoma viral proto-oncogene 2... 92 1e-19
ref|NP_033123.1| (NM_009097) ribosomal protein S6 kinase po... 91 2e-19
ref|NP_031854.1| (NM_007828) death-associated kinase 3; ZIP... 91 2e-19
ref|NP_032883.1| (NM_008857) protein kinase C, lamda [Mus m... 91 3e-19
ref|NP_035231.1| (NM_011101) protein kinase C, alpha [Mus m... 91 3e-19
ref|NP_038759.1| (NM_013731) serum/glucocorticoid regulated... 90 5e-19
ref|NP_032880.1| (NM_008854) protein kinase, cAMP dependent... 90 5e-19
ref|NP_032439.1| (NM_008413) Janus kinase 2 [Mus musculus] 90 6e-19
ref|NP_036076.1| (NM_011946) mitogen activated protein kina... 89 8e-19
ref|NP_035192.1| (NM_011062) 3-phosphoinositide dependent p... 89 8e-19
Alignments
>ref|NP_058036.1| (NM_016756) cyclin-dependent kinase 2 [Mus musculus]
Length = 298
Score = 600 bits (1548), Expect = e-173
Identities = 295/298 (98%), Positives = 297/298 (98%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
MENFQKVEKIGEGTYGVVYKA+NKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
Sbjct: 1 MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
HRVLHRDLKPQNLLIN EG+IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
Sbjct: 121 HRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Sbjct: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298
>ref|NP_031685.1| (NM_007659) cell division cycle 2 homolog A (S. pombe); cell
division cycle control protein 2a [Mus musculus]
Length = 297
Score = 389 bits (998), Expect = e-109
Identities = 192/295 (65%), Positives = 233/295 (78%), Gaps = 3/295 (1%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
ME++ K+EKIGEGTYGVVYK R+++TG++VA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1 MEDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFC 118
PNIV L DV+ +++LYL+FEFL DLKK++D S G + L+KSYL Q+LQG+ FC
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQFMDSSLVKSYLHQMLQGIVFC 119
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
HS RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHEVVTLWYR+PE+LLG
Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
YST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ DYK
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239
Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
+FPKW + V LDE+ LS+ML YDP KRIS K AL HP+F D+ +
Sbjct: 240 TFPKWNPGSLASHVKNLDENCLDFLSKMLVYDPAKRISGKMALKHPYFDDLDNQI 294
>ref|NP_031694.1| (NM_007668) cyclin-dependent kinase 5 [Mus musculus]
Length = 292
Score = 350 bits (898), Expect = 2e-97
Identities = 176/294 (59%), Positives = 219/294 (73%), Gaps = 4/294 (1%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
M+ ++K+EKIGEGTYG V+KA+N+ T E+VALK++RLD + EGVPS+A+REI LLKEL H
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV+L DV+H++ KL LVFEF QDLKK+ D S + ++KS+LFQLL+GL FCHS
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHS 119
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
VLHRDLKPQNLLIN G +KLADFGLARAFG+PVR Y+ EVVTLWYR P++L G K Y
Sbjct: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179
Query: 181 STAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
ST++D+WS GCIFAE+ R LFPG+ DQL RIFR LGTP E WP +T +PDYKP
Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKP- 238
Query: 240 FPKW-ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
+P + A VVP L+ GR LL +L +P +RISA+ AL HP+F D P
Sbjct: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292
>ref|NP_035179.1| (NM_011049) PCTAIRE-motif protein kinase 1 [Mus musculus]
Length = 496
Score = 315 bits (807), Expect = 7e-87
Identities = 158/287 (55%), Positives = 207/287 (72%), Gaps = 3/287 (1%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E + K++K+GEGTY VYK ++KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D+IHTE L LVFE+L +DLK+++D I + +K +LFQLL+GLA+CH
Sbjct: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNV-INMHNVKLFLFQLLRGLAYCHR 279
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
+VLHRDLKPQNLLIN G +KLADFGLARA +P +TY++EVVTLWYR P+ILLG Y
Sbjct: 280 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 339
Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
ST +D+W +GCIF EM T R LFPG + +QL IFR LGTP E WPG+ S +++ +
Sbjct: 340 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFRTYN 399
Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
+PK+ + P LD DG LL+++L ++ RISA+ A HPFF
Sbjct: 400 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKHPFF 446
>ref|NP_032821.1| (NM_008795) PCTAIRE-motif protein kinase 3 [Mus musculus]
Length = 451
Score = 314 bits (804), Expect = 2e-86
Identities = 158/297 (53%), Positives = 213/297 (71%), Gaps = 3/297 (1%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 118 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 176
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 177 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MNMHNVKIFMFQLLRGLAYCHH 235
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EVVTLWYR P++LLG Y
Sbjct: 236 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 295
Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
ST +D+W +GCI EM T + LFPG + ++L IFR LGTP E WPGVTS+ +++ +
Sbjct: 296 STPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRAYN 355
Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
FP++ Q P LD +G +LLS +L Y+ R+SA+AAL HP+FQ + V L
Sbjct: 356 FPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMSAEAALNHPYFQSLGDRVHQL 412
>ref|NP_035204.1| (NM_011074) PFTAIRE protein kinase 1 [Mus musculus]
Length = 469
Score = 285 bits (730), Expect = 6e-78
Identities = 152/294 (51%), Positives = 202/294 (68%), Gaps = 10/294 (3%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
++++K+EK+GEG+Y VYK ++K+ G++VALK IRL E EG P TAIRE SLLK L H
Sbjct: 133 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 191
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
NIV L D+IHT+ L LVFE++H DL ++M+ G+ +K +LFQLL+GL++ H
Sbjct: 192 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMEQHP-GGLHPDNVKLFLFQLLRGLSYIHQR 250
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
+LHRDLKPQNLLI+ G +KLADFGLARA VP TY++EVVTLWYR P++LLG YS
Sbjct: 251 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 310
Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS- 239
T +D+W +GCIF EM+ A FPG +I DQL RIF LGTP+E WPGV S+P +KP
Sbjct: 311 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 370
Query: 240 ----FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
K RQ ++K+ L S++L P R+SA+AAL+H +F D+
Sbjct: 371 FTVYSSKSLRQAWNKL--SYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 422
>ref|NP_031687.1| (NM_007661) cell division cycle 2 homolog (S. pombe)-like 2; cell
division cycle 2-like 2 [Mus musculus]
Length = 783
Score = 269 bits (688), Expect = 4e-73
Identities = 132/297 (44%), Positives = 200/297 (66%), Gaps = 5/297 (1%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 423 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 482
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL G+
Sbjct: 483 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLSGVKHL 541
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT VVTLWYRAPE+LLG K
Sbjct: 542 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 601
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
YSTAVD+WS+GCIF E++T++ LFPG S+IDQ+ +IF+ LGTP E +WPG +P K
Sbjct: 602 EYSTAVDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKK 661
Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
+F ++ + K L + G L+++ L Y P +RI+A+ L H +F++ P+
Sbjct: 662 MTFSEYPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPI 718
>ref|NP_034003.1| (NM_009873) cyclin-dependent kinase 6 [Mus musculus]
Length = 326
Score = 267 bits (682), Expect = 2e-72
Identities = 145/299 (48%), Positives = 196/299 (65%), Gaps = 13/299 (4%)
Query: 2 ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59
+ ++ V +IGEG YG V+KAR+ K G VALK++R+ T EG+P + IRE+++L+ L
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLSTIREVAVLRHLET 70
Query: 60 --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
HPN+V+L DV E KL LVFE + QDL ++D G+P IK +FQLL
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
+GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR + + T VVTLWYRAPE
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189
Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
+LL Y+T VD+WS+GCIFAEM R+ LF G S++DQL +I +G P E WP +
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVA 248
Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291
+P + +F + Q K V +DE G+ LL + L ++P KRISA AL HP+FQD+ +
Sbjct: 249 LP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQDLER 305
>ref|NP_031686.1| (NM_007660) cell division cycle 2 homolog (S. pombe)-like 1; cell
division cycle 2-like 1 [Mus musculus]
Length = 434
Score = 263 bits (673), Expect = 2e-71
Identities = 130/297 (43%), Positives = 197/297 (65%), Gaps = 5/297 (1%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 74 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 133
Query: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL G+
Sbjct: 134 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLSGVKHL 192
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
H + +LHRDLK NLL+ G +K+ DFGLAR +G P++ YT VVTLWYRAPE+LLG K
Sbjct: 193 HDNWILHRDLKTSNLLLTHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 252
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
YSTA D+WS+GCIF E++T++ LFPG S+IDQ+ +IF+ LG+P E +WPG +P K
Sbjct: 253 EYSTACDMWSVGCIFGELLTQKPLFPGKSDIDQINKIFKDLGSPSEKIWPGYNDLPAVKK 312
Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
+F + + K L + G L+++ L Y P +RI+A+ L H +F++ P+
Sbjct: 313 MTFSEIPYNNLRKRFGALLSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPI 369
>ref|NP_444410.1| (NM_053180) CDK-related protein kinase PNQLARE [Mus musculus]
Length = 346
Score = 244 bits (622), Expect = 2e-65
Identities = 129/297 (43%), Positives = 184/297 (61%), Gaps = 6/297 (2%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
M+ + + +IGEG +G+V+KA++ TGE+VALKK+ L +G+P+ A+REI L+E+
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEIED 60
Query: 61 PNIVKLLDVIHTENKLY-LVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
V L + + L FEF+ DL + + + P +KSYL LL+G+AFCH
Sbjct: 61 SQYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPAQ-VKSYLQMLLKGVAFCH 119
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYRAPEILLGCK 178
++ ++HRDLKP NLLI+ G +K+ADFGLAR F R YTH+V T WYRAPE+L G +
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGAR 179
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-K 237
Y VD+W++GCI E++ LFPG+++I+QL + R LGTP VWP +T +PDY K
Sbjct: 180 QYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPSPRVWPEITELPDYNK 239
Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294
SF + A +V+P LL Q L Y P +RI+A AL H +F T P+P
Sbjct: 240 ISFKEQAPVPLEEVLPDASPQALDLLGQFLLYPPRQRIAASQALLHQYF--FTAPLP 294
>ref|NP_034000.1| (NM_009870) cyclin-dependent kinase 4; p34/cdk4 [Mus
musculus]
Length = 303
Score = 241 bits (616), Expect = 1e-64
Identities = 132/293 (45%), Positives = 187/293 (63%), Gaps = 15/293 (5%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIREISLLKELN- 59
++ V +IG G YG VYKAR+ +G VALK +R+ G+P + +RE++LL+ L
Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLEA 65
Query: 60 --HPNIVKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
HPN+V+L+DV T K+ LVFE + QDL+ ++D + G+P+ IK + Q L
Sbjct: 66 FEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFL 125
Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
GL F H++ ++HRDLKP+N+L+ + G +KLADFGLAR + + T VVTLWYRAPE
Sbjct: 126 SGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
+LL Y+T VD+WS+GCIFAEM R+ LF G+SE DQL +IF +G P E WP S
Sbjct: 185 VLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVS 243
Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
+P + +F + VVP ++E G LL +ML ++P+KRISA AL H +
Sbjct: 244 LP--RGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
>ref|NP_058608.1| (NM_016912) cyclin-dependent kinase-like 2 (CDC2-related kinase)
[Mus musculus]
Length = 568
Score = 229 bits (583), Expect = 7e-61
Identities = 121/295 (41%), Positives = 169/295 (57%), Gaps = 13/295 (4%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
ME ++ + +GEG+YG+V K RNK +G +VA+KK + + V A+REI LLK+L H
Sbjct: 1 MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116
N+V LL+V + + YLVFEF+ DLK F + G+ +++ YLFQ++ G+
Sbjct: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPN-----GLDYQVVQKYLFQIINGIG 115
Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
FCHSH ++HRD+KP+N+L++ G +KL DFG AR P YT V T WYRAPE+L+G
Sbjct: 116 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVG 175
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT----PDEVVWPGVTS 232
Y AVDIW++GC+ EM+ + LFPG+S+IDQL I LG E+ +
Sbjct: 176 DVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVF 235
Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
P + P L E SL + LH DP+KR L H FFQ
Sbjct: 236 AGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDKRPFCADLLRHDFFQ 290
>ref|NP_032573.1| (NM_008547) male germ cell-associated kinase [Mus musculus]
Length = 622
Score = 218 bits (556), Expect = 9e-58
Identities = 115/289 (39%), Positives = 178/289 (60%), Gaps = 6/289 (2%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
M + ++++G+GTYG V ++ +GE+VA+K+++ + +RE+ LK+LNH
Sbjct: 1 MNRYTTMKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWD-ECMNLREVKSLKKLNH 59
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFM-DASALTGIPLPLIKSYLFQLLQGLAFCH 119
N++KL +VI + LY VFE++ ++L + M D + L P +I++ ++Q+LQGLAF H
Sbjct: 60 ANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKL--FPESVIRNIMYQILQGLAFIH 117
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
H HRD+KP+NLL +K+ADFGLAR YT V T WYRAPE+LL
Sbjct: 118 KHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQP-PYTDYVSTRWYRAPEVLLRSSV 176
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP-GVTSMPDYKP 238
YS+ +D+W++G I AE+ T R LFPG SE+D++F+I + LGTP + WP G
Sbjct: 177 YSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
FP+ + ++P + L+++ML++DP KR +A AL HP+FQ
Sbjct: 237 RFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYFQ 285
>ref|NP_064371.1| (NM_019987) intestinal cell kinase [Mus musculus]
Length = 629
Score = 213 bits (543), Expect = 3e-56
Identities = 117/291 (40%), Positives = 174/291 (59%), Gaps = 10/291 (3%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
M + ++++G+GTYG V R+ +GE++A+KK++ + +RE+ LK+LNH
Sbjct: 1 MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYS-WEECMNLREVKSLKKLNH 59
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
NIVKL +VI + LY +FE++ ++L + + P I++ ++Q+LQGLAF H
Sbjct: 60 ANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKL-FPESAIRNIMYQILQGLAFIHK 118
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT---YTHEVVTLWYRAPEILLGC 177
H HRDLKP+NLL +K+ADFGLAR +R+ YT V T WYRAPE+LL
Sbjct: 119 HGFFHRDLKPENLLCMGPELVKIADFGLARE----IRSRPPYTDYVSTRWYRAPEVLLRS 174
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP-GVTSMPDY 236
YS+ +DIW++GCI AE+ T R LFPG SEID +F+I + LGTP + WP G
Sbjct: 175 TNYSSPIDIWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAM 234
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
+P+ + ++P + LL +L +DP KR +A AL +P+FQ
Sbjct: 235 NFLWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQ 285
>ref|NP_570930.1| (NM_130860) cyclin-dependent kinase 9 [Mus musculus]
Length = 372
Score = 209 bits (531), Expect = 7e-55
Identities = 118/298 (39%), Positives = 174/298 (57%), Gaps = 16/298 (5%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
++K+ KIG+GT+G V+KA+++ TG+ VALKK+ ++ E EG P TA+REI +L+ L H N+
Sbjct: 19 YEKLAKIGQGTFGEVFKAKHRQTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78
Query: 64 VKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
V L+++ T + +YLVF+F DL + ++ L L IK + LL GL
Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRVMQMLLNGL 137
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----YTHEVVTLWYRAP 171
+ H +++LHRD+K N+LI +G +KLADFGLARAF + + YT+ VVTLWYR P
Sbjct: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197
Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231
E+LLG + Y +D+W GCI AEM TR + G++E QL I + G+ VWP V
Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257
Query: 232 SMPDY-KPSFPKWARQDFSKVVPPLDED--GRSLLSQMLHYDPNKRISAKAALAHPFF 286
+ K K ++ + D L+ ++L DP +RI + AL H FF
Sbjct: 258 KYELFEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
>ref|NP_035971.1| (NM_011841) mitogen-activated protein kinase 7; extracellular
signal regulated kinase 5; big MAP kinase 1 [Mus
musculus]
Length = 806
Score = 208 bits (530), Expect = 9e-55
Identities = 118/305 (38%), Positives = 168/305 (54%), Gaps = 18/305 (5%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ ++ +E IG G YGVV AR +LTG+ VA+KKI + +RE+ +LK H
Sbjct: 53 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 112
Query: 62 NIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPL--IKSYLFQLLQ 113
NI+ + D++ +Y+V + + DL + + +S PL L ++ +L+QLL+
Sbjct: 113 NIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQ----PLTLEHVRYFLYQLLR 168
Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYR 169
GL + HS +V+HRDLKP NLL+N +K+ DFG+AR + T V T WYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP- 228
APE++L Y+ A+D+WS+GCIF EM+ RR LFPG + + QL I LGTP V
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 229 -GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
G + Y S P + V P D SLL +ML ++P+ RISA AAL HPF
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 288 DVTKP 292
P
Sbjct: 349 KYHDP 353
>ref|NP_036080.1| (NM_011950) mitogen activated protein kinase 13; p38 delta MAP
kinase; SAPK/Erk/kinase 4 [Mus musculus]
Length = 366
Score = 199 bits (507), Expect = 4e-52
Identities = 113/291 (38%), Positives = 165/291 (55%), Gaps = 15/291 (5%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
+G G YG V A ++ TGE VA+KK+ ++E A RE+ LLK ++H N++ LLDV
Sbjct: 31 VGSGAYGAVCSAIDRRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDV 90
Query: 70 IHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123
+ L YLV F+ DL+K M ++ ++Q+L+GL + HS +
Sbjct: 91 FTPASSLRSFHDFYLVMPFMQTDLQKIMGME----FSEDKVQYLVYQMLKGLKYIHSAGI 146
Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183
+HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L +Y+
Sbjct: 147 VHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGY---VVTRWYRAPEVILSWMHYNQT 203
Query: 184 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP--DEVVWPGVTSMPDYKPSFP 241
VDIWS+GCI AEM+T + LF G +DQL +I + G P + V + Y S P
Sbjct: 204 VDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLP 263
Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
+ ++DF+++ P LL +ML D +KR++A ALAHPFF+ P
Sbjct: 264 QSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFFEPFRDP 314
>ref|NP_038899.1| (NM_013871) stress activated protein kinase-3; stress activated
protein kinase 3 [Mus musculus]
Length = 367
Score = 196 bits (497), Expect = 6e-51
Identities = 111/294 (37%), Positives = 164/294 (55%), Gaps = 14/294 (4%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+Q ++ +G G YG V A + TG VA+KK+ ++E A RE+ LLK + H N+
Sbjct: 27 YQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86
Query: 64 VKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
+ LLDV + L YLV F+ DL K M L+ I+ ++Q+L+GL +
Sbjct: 87 IGLLDVFTPDESLDDFTDFYLVMPFMGTDLGKLMKHETLSE---DRIQFLVYQMLKGLKY 143
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177
H+ V+HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L
Sbjct: 144 IHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNW 200
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--MPD 235
Y+ VDIWS+GCI AEM+T + LF G+ +DQL I + GTP + S +
Sbjct: 201 MRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEAKN 260
Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
Y P+ ++DF+ V+ +LL +ML D +R++A AL HP+F+ +
Sbjct: 261 YMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHPYFESL 314
>ref|NP_036081.1| (NM_011951) mitogen activated protein kinase 14; p38 MAP Kinase;
cytokine suppressive anti-inflammatory drug binding
protein 1 [Mus musculus]
Length = 360
Score = 187 bits (475), Expect = 2e-48
Identities = 112/299 (37%), Positives = 162/299 (53%), Gaps = 14/299 (4%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
E +Q + +G G YG V A + TG VA+KK+ ++ RE+ LLK + H
Sbjct: 22 ERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81
Query: 62 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
N++ LLDV + N +YLV + DL + LT + + ++Q+L+GL
Sbjct: 82 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGL 138
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175
+ HS ++HRDLKP NL +N + +K+ DFGLAR + Y V T WYRAPEI+L
Sbjct: 139 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIML 195
Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT--SM 233
+Y+ VDIWS+GCI AE++T R LFPG IDQL I R +GTP + ++ S
Sbjct: 196 NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 255
Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
+Y S + + +F+ V + LL +ML D +KRI+A ALAH +F P
Sbjct: 256 RNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 314
>ref|NP_036079.1| (NM_011949) mitogen activated protein kinase 1; protein kinase,
mitogen activated kinase 1 [Mus musculus]
Length = 358
Score = 186 bits (472), Expect = 5e-48
Identities = 111/299 (37%), Positives = 163/299 (54%), Gaps = 14/299 (4%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+ + IGEG YG+V A + L VA+KKI E + +REI +L H NI
Sbjct: 23 YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENI 81
Query: 64 VKLLDVIHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
+ + D+I +Y+V + + DL K + L+ I +L+Q+L+GL +
Sbjct: 82 IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSN---DHICYFLYQILRGLKYI 138
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP---VRTYTHEVVTLWYRAPEILL 175
HS VLHRDLKP NLL+NT +K+ DFGLAR T V T WYRAPEI+L
Sbjct: 139 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIML 198
Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP- 234
K Y+ ++DIWS+GCI AEM++ R +FPG +DQL I LG+P + + ++
Sbjct: 199 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKA 258
Query: 235 -DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
+Y S P + ++++ P D LL +ML ++P+KRI + ALAHP+ + P
Sbjct: 259 RNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 317
>ref|NP_032728.1| (NM_008702) nemo like kinase [Mus musculus]
Length = 515
Score = 183 bits (465), Expect = 3e-47
Identities = 115/297 (38%), Positives = 164/297 (54%), Gaps = 29/297 (9%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
IG G +GVV+ + G+ VALKK+ + RE+ +L H N++ LD+
Sbjct: 132 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 191
Query: 70 IHTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQLLQGLAFCHS 120
+ + ++Y+V E + DL K + + P PL +K +L+Q+L+GL + HS
Sbjct: 192 LQPPHIDYFEEIYVVTELMQSDLHKIIVS------PQPLSSDHVKVFLYQILRGLKYLHS 245
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYRAPEILLGCKY 179
+LHRD+KP NLL+N+ +K+ DFGLAR + R T EVVT +YRAPEIL+G ++
Sbjct: 246 AGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRH 305
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD--------EVVWPGVT 231
YS A+DIWS+GCIFAE++ RR LF S I QL I LGTP E +
Sbjct: 306 YSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHIL 365
Query: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
P +PS P + + LL +ML +DP+KRISAK ALAHP+ +
Sbjct: 366 RGPHKQPSLPV-----LYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDE 417
>ref|NP_035291.2| (NM_011161) protein kinase, mitogen activated kinase, 11, p38beta
[Mus musculus]
Length = 364
Score = 180 bits (457), Expect = 3e-46
Identities = 109/299 (36%), Positives = 161/299 (53%), Gaps = 14/299 (4%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ Q + +G G YG V A + + VA+KK+ ++ RE+ LLK L H
Sbjct: 22 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 81
Query: 62 NIVKLLDV------IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
N++ LLDV I +++YLV + DL + AL+ + + ++QLL+GL
Sbjct: 82 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFL---VYQLLRGL 138
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175
+ HS ++HRDLKP N+ +N + +++ DFGLA + Y V T WYRAPEI+L
Sbjct: 139 KYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAPQADEEMTGY---VATRWYRAPEIML 195
Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--M 233
+Y+ VDIWS+GCI AE++ +ALFPG+ IDQL RI +GTP V ++S
Sbjct: 196 NWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHA 255
Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
Y S P ++D S V + LL +ML D ++R+SA ALAH +F P
Sbjct: 256 RTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYRDP 314
>ref|NP_033184.1| (NM_009158) mitogen activated protein kinase 10; SAPK/Erk/kinase 2
[Mus musculus]
Length = 422
Score = 173 bits (439), Expect = 3e-44
Identities = 118/325 (36%), Positives = 170/325 (52%), Gaps = 39/325 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH
Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120
Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 110
NI+ LL+V + L YLV E MDA+ I + L + L+Q
Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMEL--------MDANLCQVIQMELDHERMSYLLYQ 172
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
+L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRA
Sbjct: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-TPYVVTRYYRA 231
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPG 229
PE++LG Y VDIWS+GCI EMV + LFPG S IDQ ++ LGTP E +
Sbjct: 232 PEVILGMGYKEN-VDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKL 290
Query: 230 VTSMPDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISA 277
++ +Y + PK+A F K+ P P D + R LLS+ML DP KRIS
Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISV 350
Query: 278 KAALAHPFFQ------DVTKPVPHL 296
AL HP+ +V P P +
Sbjct: 351 DDALQHPYINVWYDPAEVEAPPPQI 375
>ref|NP_062801.1| (NM_019827) glycogen synthase kinase 3 beta [Mus musculus]
Length = 420
Score = 170 bits (430), Expect = 4e-43
Identities = 102/304 (33%), Positives = 176/304 (57%), Gaps = 26/304 (8%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
++ + IG G++GVVY+A+ +GE+VA+KK+ D + RE+ ++++L+H N
Sbjct: 55 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCN 108
Query: 63 IVKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQG 114
IV+L ++ + L LV +++ + + + + A +P+ +K Y++QL +
Sbjct: 109 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168
Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAF--GVPVRTYTHEVVTLWYRAP 171
LA+ HS + HRD+KPQNLL++ + A+ KL DFG A+ G P +Y + + +YRAP
Sbjct: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAP 225
Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT 231
E++ G Y++++D+WS GC+ AE++ + +FPGDS +DQL I + LGTP +
Sbjct: 226 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR---EQIR 282
Query: 232 SM-PDYKP-SFPKWARQDFSKVV-PPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
M P+Y FP+ ++KV P + +L S++L Y P R++ A AH FF +
Sbjct: 283 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 342
Query: 289 VTKP 292
+ P
Sbjct: 343 LRDP 346
>ref|NP_058657.1| (NM_016961) mitogen activated protein kinase 9; Jun kinase;
JNK/SAPK alpha; protein kinase, mitogen-activated 9 [Mus
musculus]
Length = 381
Score = 169 bits (429), Expect = 5e-43
Identities = 113/308 (36%), Positives = 162/308 (51%), Gaps = 33/308 (10%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
++ +Q+++ IG G G+V A + + G VA+KK+ + + A RE+ LLK +NH
Sbjct: 23 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 82
Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 110
NI+ LL+V + L YLV E MDA+ I + L + L+Q
Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMEL--------MDANLCQVIHMELDHERMSYLLYQ 134
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
+L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR T VVT +YRA
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMM-TPYVVTRYYRA 193
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD----EVV 226
PE++LG Y VDIWS+GCI AEMV + LFPG IDQ ++ LGTP + +
Sbjct: 194 PEVILGMGYKEN-VDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKL 252
Query: 227 WPGVTSMPDYKPS---------FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA 277
P V + + +P FP W S+ R LLS+ML DP+KRIS
Sbjct: 253 QPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISV 312
Query: 278 KAALAHPF 285
AL HP+
Sbjct: 313 DEALRHPY 320
>ref|NP_057909.1| (NM_016700) mitogen activated protein kinase 8; c-Jun N-terminal
kinase; protein kinase mitogen-activated 8 [Mus
musculus]
Length = 384
Score = 169 bits (427), Expect = 8e-43
Identities = 111/308 (36%), Positives = 163/308 (52%), Gaps = 33/308 (10%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH
Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82
Query: 61 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 110
NI+ LL+V + L Y+V E MDA+ I + L + L+Q
Sbjct: 83 KNIIGLLNVFTPQKSLEEFQDVYIVMEL--------MDANLCQVIQMELDHERMSYLLYQ 134
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
+L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRA
Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRA 193
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPG 229
PE++LG Y VD+WS+GCI EMV + LFPG IDQ ++ LGTP E +
Sbjct: 194 PEVILGMGYKEN-VDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252
Query: 230 VTSMPDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISA 277
++ Y + PK+A F K+ P P D + R LLS+ML D +KRIS
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 278 KAALAHPF 285
AL HP+
Sbjct: 313 DEALQHPY 320
>ref|NP_056621.1| (NM_015806) mitogen-activated protein kinase 6; mitogen activated
protein kinase 4; Erk-3 related; protein kinase, mitogen
activated kinase 4 [Mus musculus]
Length = 720
Score = 160 bits (406), Expect = 2e-40
Identities = 103/311 (33%), Positives = 171/311 (54%), Gaps = 30/311 (9%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+ ++ +G G G+V+ A + + VA+KKI L T+ + V A+REI +++ L+H NI
Sbjct: 20 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVL-TDPQSVKH-ALREIKIIRRLDHDNI 77
Query: 64 VKLLDVIHTE--------------NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 109
VK+ +++ N +Y+V E++ DL ++ +L L +++
Sbjct: 78 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGSLLEEHARL---FMY 134
Query: 110 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAFGVPVRTYTHE------ 162
QLL+GL + HS VLHRDLKP NL INTE + K+ DFGLAR Y+H+
Sbjct: 135 QLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPH---YSHKGHLSEG 191
Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222
+VT WYR+P +LL Y+ A+D+W+ GCIFAEM+T + LF G E++Q+ I ++
Sbjct: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVV 251
Query: 223 DEVVWPGVTS-MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281
E + S +P Y + + ++++P + + L Q+L + P R++A+ AL
Sbjct: 252 HEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL 311
Query: 282 AHPFFQDVTKP 292
+HP+ + P
Sbjct: 312 SHPYMSIYSFP 322
>ref|NP_036103.1| (NM_011973) renal tumor antigen; MAPK/MAK/MRK/ overlapping kinase
[Mus musculus]
Length = 420
Score = 160 bits (405), Expect = 3e-40
Identities = 103/295 (34%), Positives = 159/295 (52%), Gaps = 17/295 (5%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET-EGVPSTAIREISLLKELN 59
M+N++ + KIGEGT+ V K ++ G A K+++ E+ E V S +REI L+ LN
Sbjct: 1 MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNS--LREIQALRRLN 58
Query: 60 -HPNIVKLLDVI--HTENKLYLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQLL 112
HPNI+ L +V+ L L+ E + ++ + + G PL I Y++QL
Sbjct: 59 PHPNILALHEVVFDRKSGSLALICELMDMNIYEL-----IRGRRHPLSEKKIMLYMYQLC 113
Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
+ L H + + HRD+KP+N+L+ + +KL DFG R+ + YT + T WYRAPE
Sbjct: 114 KSLDHMHRNGIFHRDVKPENILVKQD-VLKLGDFGSCRSV-YSKQPYTEYISTRWYRAPE 171
Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
LL +Y+ +D+WS GC+F E+ + + LFPG +E+DQ+ +I +GTP +
Sbjct: 172 CLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPCQKTLTKFKQ 231
Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
FP + L SLL M+ YDP++RI+A AL HP+FQ
Sbjct: 232 SRAMSFDFPFKKGSGIPLLTANLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQ 286
>ref|NP_034104.1| (NM_009974) casein kinase II, alpha 2, polypeptide [Mus musculus]
Length = 350
Score = 140 bits (352), Expect = 4e-34
Identities = 97/305 (31%), Positives = 161/305 (51%), Gaps = 27/305 (8%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60
+++Q V K+G G Y V++A N E V +K ++ + + RE+ +L+ L
Sbjct: 38 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRGG 92
Query: 61 PNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
NI+KL+D + LVFE+++ D K+ LT I+ Y+++LL+ L +
Sbjct: 93 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFD---IRFYMYELLKALDY 147
Query: 118 CHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
CHS ++HRD+KP N++I+ + ++L D+GLA F P + Y V + +++ PE+L+
Sbjct: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVD 206
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235
+ Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT DE+ D
Sbjct: 207 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGT-DELYGYLKKYHID 265
Query: 236 YKPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
P F +W S+ + + LL ++L YD +R++AK A+ HP+F
Sbjct: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325
Query: 287 QDVTK 291
V K
Sbjct: 326 YPVVK 330
>ref|NP_031814.1| (NM_007788) casein kinase II, alpha 1 related sequence 4; casein
kinase II, alpha 1, related sequence 4 [Mus musculus]
Length = 391
Score = 136 bits (342), Expect = 6e-33
Identities = 95/305 (31%), Positives = 160/305 (52%), Gaps = 27/305 (8%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60
+++Q V K+G G Y V++A N E V +K ++ + + REI +L+ L
Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
Query: 61 PNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
PNI+ L D++ LVFE ++ D K+ LT I+ Y++++L+ L +
Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYD---IRFYMYEILKALDY 146
Query: 118 CHSHRVLHRDLKPQNLLINTEGA-IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
CHS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+
Sbjct: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVD 205
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235
+ Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + ++ +
Sbjct: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI-E 264
Query: 236 YKPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
P F +W R S+ + + L ++L YD R++A+ A+ HP+F
Sbjct: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
Query: 287 QDVTK 291
V K
Sbjct: 325 YTVVK 329
>ref|NP_031813.1| (NM_007787) casein kinase II, alpha 1 polypeptide; casein kinase
II, alpha 1, polypeptide [Mus musculus]
Length = 391
Score = 135 bits (341), Expect = 8e-33
Identities = 95/305 (31%), Positives = 159/305 (51%), Gaps = 27/305 (8%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60
+++Q V K+G G Y V++A N E V +K ++ + + REI +L+ L
Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKK-----IKREIKILENLRGG 91
Query: 61 PNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
PNI+ L D++ LVFE ++ D K+ LT I+ Y++++L+ L +
Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQT--LTDYD---IRFYMYEILKALDY 146
Query: 118 CHSHRVLHRDLKPQNLLINTEGA-IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
CHS ++HRD+KP N++I+ E ++L D+GLA F P + Y V + +++ PE+L+
Sbjct: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLVD 205
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235
+ Y ++D+WSLGC+ A M+ R+ F G DQL RI + LGT D + ++ +
Sbjct: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNI-E 264
Query: 236 YKPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
P F +W R S+ + + L ++L YD R++ + A+ HPFF
Sbjct: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTVREAMEHPFF 324
Query: 287 QDVTK 291
V K
Sbjct: 325 YTVVK 329
>ref|NP_034222.1| (NM_010092) dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1b [Mus musculus]
Length = 589
Score = 132 bits (331), Expect = 1e-31
Identities = 97/297 (32%), Positives = 151/297 (50%), Gaps = 22/297 (7%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E ++ IG+G++G V KA + T E+VA+K I+ + + A E+ LL+ +N
Sbjct: 108 LERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIK---NKKAFLNQAQIELRLLELMNQ 164
Query: 61 PNIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
+ ++H + N L LVFE L +L + + G+ L L + QL
Sbjct: 165 HDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTA 224
Query: 115 LAFCHSHR--VLHRDLKPQNLLINT--EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
L F + ++H DLKP+N+L+ AIK+ DFG + G + Y + + +YR+
Sbjct: 225 LLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRFYRS 281
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
PE+LLG Y A+D+WSLGCI EM T LF G +E+DQ+ RI LG P P +
Sbjct: 282 PEVLLGTPY-DLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPA---PML 337
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
P + F + ++ + E + L+ +ML Y+P RIS AL H FF+
Sbjct: 338 EQAPKARKYFERLPGGGWT--LRRTKELRKDLVLRMLEYEPAARISPLGALQHGFFR 392
>ref|NP_067619.1| (NM_021606) NIMA-related expressed kinase 6 [Mus musculus]
Length = 313
Score = 129 bits (323), Expect = 9e-31
Identities = 86/235 (36%), Positives = 119/235 (50%), Gaps = 11/235 (4%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG-VPSTAIREISLLKELN 59
+ +FQ +KIG G + VYKA L + VALKK+++ + ++EI LLK+LN
Sbjct: 42 LADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN 101
Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
HPNI+K LD +N+L +V E L Q +K F L IP + Y QL
Sbjct: 102 HPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRL--IPERTVWKYFVQLCSA 159
Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174
+ HS RV+HRD+KP N+ I G +KL D GL R F V T +Y +PE
Sbjct: 160 VEHMHSRRVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPE-R 218
Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
+ Y+ DIWSLGC+ EM ++ F GD LF + + + D PG
Sbjct: 219 IHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM--NLFSLCQKIEQCDYPPLPG 271
>ref|NP_067618.1| (NM_021605) NIMA (never in mitosis gene a)-related expressed kinase
7; NIMA-related expressed kinase 7 [Mus musculus]
Length = 302
Score = 125 bits (315), Expect = 8e-30
Identities = 80/212 (37%), Positives = 110/212 (51%), Gaps = 9/212 (4%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-DTETEGVPSTAIREISLLKELN 59
+ NF+ +KIG G + VY+A L G VALKK+++ D + I+EI LLK+LN
Sbjct: 31 LANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90
Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
HPN++K +N+L +V E L + +K F L IP + Y QL
Sbjct: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRL--IPERTVWKYFVQLCSA 148
Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174
L HS RV+HRD+KP N+ I G +KL D GL R F V T +Y +PE
Sbjct: 149 LDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE-R 207
Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGD 206
+ Y+ DIWSLGC+ EM ++ F GD
Sbjct: 208 IHENGYNFKSDIWSLGCLLYEMAALQSPFYGD 239
>ref|NP_067491.1| (NM_021516) MAP/microtubule affinity-regulating kinase 3; ELKL
motif kinase 2 long form [Mus musculus]
Length = 744
Score = 120 bits (301), Expect = 3e-28
Identities = 76/215 (35%), Positives = 115/215 (53%), Gaps = 2/215 (0%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
N++ ++ IG+G + V AR+ LTG VA+K I RE+ ++K LNHPN
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 114
Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
IVKL +VI TE LYL+ E+ + F A + ++ Q++ + +CH R
Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKR 173
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182
++HRDLK +NLL++ + IK+ADFG + F V + T + Y APE+ G KY
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTF-CGSPPYAAPELFQGKKYDGP 232
Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217
VD+WSLG I +V+ F G + + R+ R
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 267
>ref|NP_032804.1| (NM_008778) p21 (CDKN1A)-activated kinase 3 [Mus musculus]
Length = 544
Score = 120 bits (301), Expect = 3e-28
Identities = 90/295 (30%), Positives = 144/295 (48%), Gaps = 32/295 (10%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ + ++EKIG+G G VY A + TG+ VA+K++ L + + I EI +++E +P
Sbjct: 266 KKYTRLEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNP 323
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
NIV LD ++L++V E+L D T + + I + + LQ L F HS+
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGG--SLTDVVTETCMDVGQIAAVCRECLQALDFLHSN 381
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
+V+HRD+K N+L+ +G++KL DFG + V T ++ APE++ K Y
Sbjct: 382 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KAYG 440
Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241
VDIWSLG + EMV + ++ + L+ + T GTP+ P
Sbjct: 441 PKVDIWSLGIMAIEMVEGEPPYLNENPLRALY-LIATNGTPEL-----------QNPERL 488
Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
DF L++ L D ++R SAK L HPF + + KP+ L
Sbjct: 489 SAVFHDF--------------LNRCLEMDVDRRGSAKELLQHPFLK-LAKPLSSL 528
>ref|NP_073712.1| (NM_022801) MAP/microtubule affinity-regulating kinase 3; ELKL
motif kinase 2 long form [Mus musculus]
Length = 729
Score = 120 bits (301), Expect = 3e-28
Identities = 76/215 (35%), Positives = 115/215 (53%), Gaps = 2/215 (0%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
N++ ++ IG+G + V AR+ LTG VA+K I RE+ ++K LNHPN
Sbjct: 55 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 114
Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
IVKL +VI TE LYL+ E+ + F A + ++ Q++ + +CH R
Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKR 173
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182
++HRDLK +NLL++ + IK+ADFG + F V + T + Y APE+ G KY
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTF-CGSPPYAAPELFQGKKYDGP 232
Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217
VD+WSLG I +V+ F G + + R+ R
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 267
>ref|NP_034961.1| (NM_010831) myocardial SNF1-like kinase [Mus musculus]
Length = 779
Score = 119 bits (299), Expect = 6e-28
Identities = 92/291 (31%), Positives = 142/291 (48%), Gaps = 44/291 (15%)
Query: 4 FQKVEK-IGEGTYGVVYKARNKLTGEVVALK---KIRLDTETEGVPSTAIREISLLKELN 59
F VE+ +G+G + VV AR+++T VA+K K RLD+ RE+ L+K LN
Sbjct: 26 FYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNL---EKIYREVQLMKLLN 82
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFC 118
HPNI+KL V+ T++ LY+V EF + D G + + +Q+L + +C
Sbjct: 83 HPNIIKLYQVMETKDMLYIVTEFAKNG--EMFDYLTSNGHLSENEARQKFWQILSAVEYC 140
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLG 176
H+H ++HRDLK +NLL+++ IKLADFG + G P+ T V + Y APE+ G
Sbjct: 141 HNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTC---VGSPPYAAPEVFEG 197
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
+Y +D+WSLG + +V F G + L T + V G +P +
Sbjct: 198 KEYEGPQLDVWSLGVVLYVLVCGSLPFDGPN-----------LPTLRQRVLEGRFRIPFF 246
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
+ +D +L+ +ML DP KRI+ H + Q
Sbjct: 247 ------------------MSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQ 279
>ref|NP_036078.1| (NM_011948) mitogen activated protein kinase kinase kinase 4; MEK
kinase 4; DNA segment, Chr 17, Roswell Park-17, expressed
[Mus musculus]
Length = 1545
Score = 118 bits (296), Expect = 1e-27
Identities = 84/293 (28%), Positives = 134/293 (45%), Gaps = 36/293 (12%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
+Q+ KIGEG YG VY + TGE++A+K+IR E+ + + + HPN+
Sbjct: 1280 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNL 1339
Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123
V+ V ++Y+ E+ + ++ + G+ +I+ Y Q+ + H H +
Sbjct: 1340 VRYFGVELHREEMYIFMEYCDEGT---LEEVSRLGLQEHVIRLYTKQITVAINVLHEHGI 1396
Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----VTLWYRAPEILLGCK- 178
+HRD+K N+ + + G IKL DFG + +T EV T Y APE++ K
Sbjct: 1397 VHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKG 1456
Query: 179 -YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237
+ A DIWSLGC+ EMVT + + E + F+I +G +K
Sbjct: 1457 EGHGRAADIWSLGCVVIEMVTGKRPW---HEYEHNFQIMYKVGM-------------GHK 1500
Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290
P P+ L +G++ LS L DP R +A L H F + T
Sbjct: 1501 PPIPE-----------RLSPEGKAFLSHCLESDPKIRWTASQLLDHAFVKVCT 1542
>ref|NP_033314.1| (NM_009288) serine/threonine kinase 10 [Mus musculus]
Length = 966
Score = 117 bits (292), Expect = 4e-27
Identities = 92/289 (31%), Positives = 137/289 (46%), Gaps = 34/289 (11%)
Query: 7 VEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66
V ++G+G +G VYKA+NK TG + A K I +T++E I EI +L +HP IVKL
Sbjct: 39 VGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDYIVEIEILATCDHPYIVKL 96
Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126
L + + KL+++ EF + G+ P I+ Q+L+ L F H R++HR
Sbjct: 97 LGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHGKRIIHR 156
Query: 127 DLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY-----YS 181
DLK N+L+ EG I+LADFG++ ++ + T ++ APE++L C+ Y
Sbjct: 157 DLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVL-CETMKDAPYD 215
Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241
DIWSLG EM + P E++ + R+ + D P P
Sbjct: 216 YKADIWSLGITLIEMA---QIEPPHHELNPM-RVLLKIAKSD----PPTLLTPS------ 261
Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290
KW+ + R L L +P R SA L HPF VT
Sbjct: 262 KWS------------VEFRDFLKIALDKNPETRPSAAQLLQHPFVSRVT 298
>ref|NP_062609.1| (NM_019635) serine/threonine kinase 3 (Ste20, yeast homolog) STK3;
protein kinase homolog [Mus musculus]
Length = 445
Score = 116 bits (290), Expect = 6e-27
Identities = 91/301 (30%), Positives = 148/301 (48%), Gaps = 42/301 (13%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
E F +EK+GEG+YG V+KA +K +G+VVA+K++ ++++ + + I+EIS++++ + P
Sbjct: 25 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSP 80
Query: 62 NIVKLLDVIHTENKLYLVFEFLH----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
+VK L++V E+ D+ + + + ++KS L+GL +
Sbjct: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILKS----TLKGLEY 136
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177
H R +HRD+K N+L+NTEG KLADFG+A + + T ++ APE++
Sbjct: 137 LHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 196
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237
Y A DIWSLG EM + P ++I + IF P
Sbjct: 197 GYNCVA-DIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNP--------------P 238
Query: 238 PSFPKWARQDFSKVVPPL-DEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
P+F K P L +D + + L P +R +A L HPF ++ KPV L
Sbjct: 239 PTFRK----------PELWSDDFTDFVKKCLVKSPEQRATATQLLQHPFIKN-AKPVSIL 287
Query: 297 R 297
R
Sbjct: 288 R 288
>ref|NP_035165.1| (NM_011035) p21 (CDKN1A)-activated kinase 1 [Mus musculus]
Length = 545
Score = 115 bits (289), Expect = 8e-27
Identities = 89/295 (30%), Positives = 138/295 (46%), Gaps = 32/295 (10%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ + EKIG+G G VY A + TG+ VA+K++ L + + I EI +++E +P
Sbjct: 268 KKYTPFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNP 325
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
NIV LD ++L++V E+L D T + I + + LQ L F HS+
Sbjct: 326 NIVNYLDSYLVGDELWVVMEYLAGG--SLTDVVTETCMDEGQIAAVCRECLQALEFLHSN 383
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
+V+HRD+K N+L+ +G++KL DFG + V T ++ APE++ K Y
Sbjct: 384 QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KAYG 442
Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241
VDIWSLG + EM+ + ++ + L+ + T GTP+ P+
Sbjct: 443 PKVDIWSLGIMAIEMIEGEPPYLNENPLRALY-LIATNGTPE-------LQNPE------ 488
Query: 242 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
L R L L D KR SAK L H F + + KP+ L
Sbjct: 489 ------------KLSAIFRDFLQCCLEMDVEKRGSAKELLQHQFLK-IAKPLSSL 530
>ref|NP_067395.1| (NM_021420) serine/threonine kinase 4; STE20-like kinase MST1;
Yeast Sps1/Ste20-related kinase 3 (S. cerevisiae) [Mus
musculus]
Length = 487
Score = 115 bits (289), Expect = 8e-27
Identities = 87/285 (30%), Positives = 137/285 (47%), Gaps = 33/285 (11%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
E F +EK+GEG+YG VYKA +K TG++VA+K++ ++++ + + I+EIS++++ + P
Sbjct: 28 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI----IKEISIMQQCDSP 83
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
++VK L++V E+ + + I + L L+GL + H
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 143
Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
R +HRD+K N+L+NTEG KLADFG+A + + T ++ APE++ Y
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 203
Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 241
A DIWSLG EM + P ++I + IF P P+F
Sbjct: 204 VA-DIWSLGITAIEMAEGK---PPYADIHPMRAIFMIPTNP--------------PPTFR 245
Query: 242 KWARQDFSKVVPPLDEDG-RSLLSQMLHYDPNKRISAKAALAHPF 285
K P L D + Q L P +R +A L HPF
Sbjct: 246 K----------PELWSDNFMDFVKQCLVKSPEQRATATQLLQHPF 280
>ref|NP_034562.1| (NM_010432) homeodomain interacting protein kinase 1 [Mus musculus]
Length = 1209
Score = 114 bits (286), Expect = 2e-26
Identities = 101/339 (29%), Positives = 154/339 (44%), Gaps = 66/339 (19%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELN 59
+++ +E +G GT+G V K + T E+VA+K ++ PS A + E+S+L L+
Sbjct: 189 SYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILK------NHPSYARQGQIEVSILSRLS 242
Query: 60 HPN-----IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
N V+ + +N LVFE L Q+L F+ + + +PL I+ L Q+
Sbjct: 243 SENADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATA 302
Query: 115 LAFCHSHRVLHRDLKPQNLL----INTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYR 169
L S ++H DLKP+N++ + +K+ DFG A V TY + +YR
Sbjct: 303 LMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQ---SRYYR 359
Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
APEI+LG + A+D+WSLGC+ AE+ L+PG SE DQ+ I +T G P E +
Sbjct: 360 APEIILGLPFCE-AIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSA 418
Query: 230 VTSMP-----DYKPSFPKW------------------ARQ-------DFSKVVPPLDEDG 259
T D +P W AR+ D ++V D +G
Sbjct: 419 GTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMSTDLEG 478
Query: 260 R-------------SLLSQMLHYDPNKRISAKAALAHPF 285
LL +ML D +KRI+ L H F
Sbjct: 479 TDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQF 517
>ref|NP_031954.1| (NM_007928) ELKL motif kinase [Mus musculus]
Length = 774
Score = 114 bits (286), Expect = 2e-26
Identities = 75/219 (34%), Positives = 116/219 (52%), Gaps = 10/219 (4%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
N++ ++ IG+G + V AR+ LTG+ VA+K I RE+ ++K LNHPN
Sbjct: 52 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 111
Query: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
IVKL +VI TE LYLV E+ + F A + ++ Q++ + +CH
Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGG-EVFDYLVAHGRMKEKEARAKFRQIVLHVQYCHQKF 170
Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW----YRAPEILLGCK 178
++HRDLK +NLL++ + IK+ADFG + F T+ +++ T Y APE+ G K
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEF-----TFGNKLDTFCGSPPYAAPELFQGKK 225
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFR 217
VD+WSLG I +V+ F G + + R+ R
Sbjct: 226 IDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 264
>ref|NP_034563.1| (NM_010433) homeodomain interacting protein kinase 2 [Mus musculus]
Length = 1189
Score = 114 bits (284), Expect = 3e-26
Identities = 84/258 (32%), Positives = 129/258 (49%), Gaps = 28/258 (10%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNH 60
++ +E +G GT+G V K + T E+VA+K ++ PS A + E+S+L L+
Sbjct: 192 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILK------NHPSYARQGQIEVSILARLST 245
Query: 61 P-----NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
N V+ + +N LVFE L Q+L F+ + + +PL I+ L Q+ L
Sbjct: 246 ESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATAL 305
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPV-RTYTHEVVTLWYRA 170
S ++H DLKP+N+++ +K+ DFG A V TY + +YRA
Sbjct: 306 MKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQ---SRYYRA 362
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
PEI+LG + A+D+WSLGC+ AE+ L+PG SE DQ+ I +T G P E +
Sbjct: 363 PEIILGLPFCE-AIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAG 421
Query: 231 TSMP-----DYKPSFPKW 243
T D +P W
Sbjct: 422 TKTTRFFNRDTDSPYPLW 439
>ref|NP_035622.1| (NM_011492) serine/threonine kinase 11 [Mus musculus]
Length = 436
Score = 113 bits (283), Expect = 4e-26
Identities = 88/290 (30%), Positives = 139/290 (47%), Gaps = 46/290 (15%)
Query: 10 IGEGTYGVVYKARNKLT---GEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66
+GEG+YG V + + T V LKK +L G + +EI LL+ L H N+++L
Sbjct: 55 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVK-KEIQLLRRLRHRNVIQL 113
Query: 67 LDVIHTENK--LYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124
+DV++ E K +Y+V E+ +++ +D+ P+ Y QL+ GL + HS ++
Sbjct: 114 VDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIV 173
Query: 125 HRDLKPQNLLINTEGAIKLADFGLARA---FGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
H+D+KP NLL+ T G +K++D G+A A F V T + ++ PEI G +S
Sbjct: 174 HKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPA-FQPPEIANGLDTFS 232
Query: 182 -TAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
VDIWS G + T F GD+ ++++F +G
Sbjct: 233 GFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIG-------------------- 268
Query: 241 PKWARQDFS---KVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
R DF+ PPL + LL ML Y+P KR S + H +F+
Sbjct: 269 ----RGDFTIPCDCGPPLSD----LLRGMLEYEPAKRFSIRQIRQHSWFR 310
>ref|NP_033315.1| (NM_009289) serine/threonine kinase 2; Ste20-related kinase [Mus
musculus]
Length = 1233
Score = 112 bits (280), Expect = 9e-26
Identities = 92/305 (30%), Positives = 145/305 (47%), Gaps = 43/305 (14%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
E ++ + ++G+G +G VYKA+NK T + A K I DT++E + EI +L +HP
Sbjct: 32 EFWEIIGELGDGAFGKVYKAQNKETNVLAAAKVI--DTKSEEELEDYMVEIDILASCDHP 89
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF----QLLQGLAF 117
NIVKLLD + EN L+++ EF +DA L + PL +S + Q L+ L +
Sbjct: 90 NIVKLLDAFYYENNLWILIEFCAGGA---VDAVMLE-LERPLTESQIQVVCKQTLEALNY 145
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177
H ++++HRDLK N+L +G IKLADFG++ ++ + T ++ APE+++ C
Sbjct: 146 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVM-C 204
Query: 178 -----KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
+ Y D+WSLG EM + P E++ P V+ S
Sbjct: 205 ETSKDRPYDYKADVWSLGITLIEMA---EIEPPHHELN-----------PMRVLLKIAKS 250
Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ-DVTK 291
P KW+ + + L + L + + R + L HPF D K
Sbjct: 251 EPPTLAQPSKWS------------SNFKDFLRKCLEKNVDARWTTSQLLQHPFVTVDSNK 298
Query: 292 PVPHL 296
PV L
Sbjct: 299 PVREL 303
>ref|NP_032882.1| (NM_008856) protein kinase C, eta [Mus musculus]
Length = 683
Score = 112 bits (280), Expect = 9e-26
Identities = 91/308 (29%), Positives = 144/308 (46%), Gaps = 61/308 (19%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58
++NF+ + +G+G++G V AR K TGE+ A+K ++ D + + V T + L
Sbjct: 352 IDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVILQDDDVECTMTEKRILSLAR 411
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQ 110
NHP + +L T ++L+ V EF++ Q ++F +A A + Y +
Sbjct: 412 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARA---------RFYAAE 462
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLAR---AFGVPVRTYTHEVVTLW 167
++ L F H +++RDLK N+L++ EG KLADFG+ + GV T+ T
Sbjct: 463 IISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCG---TPD 519
Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227
Y APEIL Y AVD W++G + EM+ A F ++E D LF DEVV
Sbjct: 520 YIAPEILQE-MLYGPAVDWWAMGVLLYEMLCGHAPFEAENE-DDLFEAILN----DEVV- 572
Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISA------KAAL 281
+P W L ED R +L + +P R+ + L
Sbjct: 573 ------------YPTW-----------LHEDARGILKSFMTKNPTMRLGSLTQGGEHEIL 609
Query: 282 AHPFFQDV 289
HPFF+++
Sbjct: 610 RHPFFKEI 617
>ref|NP_057902.1| (NM_016693) mitogen-activated protein kinase kinase kinase 6;
apoptosis signal-regulating kinase 2 [Mus musculus]
Length = 1289
Score = 112 bits (279), Expect = 1e-25
Identities = 97/291 (33%), Positives = 134/291 (45%), Gaps = 50/291 (17%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
+G GTYGVVY R++ T +A+K+I P EI+L K L H NIV+ L
Sbjct: 653 LGRGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLH--EEIALHKRLRHKNIVRYLGS 710
Query: 70 IHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL------IKSYLFQLLQGLAFCHSHRV 123
L + E ++ +S L + PL I Y Q+LQGL++ H +R+
Sbjct: 711 ASQGGYLKIFME----EVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRI 766
Query: 124 LHRDLKPQNLLINT-EGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEIL-LGCKYY 180
+HRD+K N+LINT G +K++DFG + R G+ T T TL Y APEI+ G + Y
Sbjct: 767 VHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETF-TGTLQYMAPEIIDQGPRGY 825
Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
A DIWSLGC EM T R F LG+P ++
Sbjct: 826 GKAADIWSLGCTVIEMATGRP-------------PFHELGSPQAAMF------------- 859
Query: 241 PKWARQDFSKVVPP----LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
+ KV PP L + ++ L + DP R SA+ L PF Q
Sbjct: 860 ----QVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQ 906
>ref|NP_032884.1| (NM_008858) protein kinase C, mu [Mus musculus]
Length = 918
Score = 110 bits (276), Expect = 3e-25
Identities = 84/288 (29%), Positives = 140/288 (48%), Gaps = 40/288 (13%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALK---KIRLDTETEGVPSTAIREISLLKELNHPNIV 64
E +G G +G+VY +++ TG VA+K K+R T+ E S E+++L+ L+HP +V
Sbjct: 593 EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE---SQLRNEVAILQNLHHPGVV 649
Query: 65 KLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124
L + T ++++V E LH D+ + + +S +P + K + Q+L L H ++
Sbjct: 650 NLECMFETPERVFVVMEKLHGDMLEMILSSEKGWLPEHITKFLITQILVALRHLHFKNIV 709
Query: 125 HRDLKPQNLLINTEG---AIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCKYY 180
H DLKP+N+L+ + +KL DFG AR G +++ VV T Y APE+L K Y
Sbjct: 710 HCDLKPENVLLASADPFPQVKLCDFGFARIIG--EKSFRRSVVGTPAYLAPEVLRN-KGY 766
Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
+ ++D+WS+G I V+ FP + DE + + + P
Sbjct: 767 NRSLDMWSVGVII--YVSLSGTFPFNE---------------DEDIHDQIQNAAFMYPPN 809
Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
P W + + L++ +L KR S L+HP+ QD
Sbjct: 810 P-WKE---------ISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQD 847
>ref|NP_034564.1| (NM_010434) homeodomain interacting protein kinase 3 [Mus musculus]
Length = 1192
Score = 110 bits (275), Expect = 3e-25
Identities = 78/234 (33%), Positives = 123/234 (52%), Gaps = 23/234 (9%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR---EISLLKELNH 60
++ ++ +G GT+G V K + T E+VA+K ++ PS A + E+S+L L+
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILK------NHPSYARQGQIEVSILARLST 250
Query: 61 PN-----IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
N V+ + N LVFE L Q+L F+ + + +PL +I+ L Q+ L
Sbjct: 251 ENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATAL 310
Query: 116 AFCHSHRVLHRDLKPQNLL----INTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYRA 170
S ++H DLKP+N++ + +K+ DFG A V TY + + +YRA
Sbjct: 311 KKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTY---LQSRYYRA 367
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDE 224
PEI+LG + A+D+WSLGC+ AE+ L+PG E DQ+ I +T G P E
Sbjct: 368 PEIILGLP-FCEAIDMWSLGCVIAELFLGWPLYPGALEHDQIRYISQTQGLPGE 420
>ref|NP_065597.1| (NM_020572) serine/threonine kinase 13 (aurora/IPL-like) [Mus
musculus]
Length = 282
Score = 109 bits (273), Expect = 6e-25
Identities = 79/299 (26%), Positives = 144/299 (47%), Gaps = 44/299 (14%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELN 59
+ +F+ +G G +G VY AR K +VALK + + + E EG+ RE+ + L
Sbjct: 13 INDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQ 72
Query: 60 HPNIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
H NI++L + + + ++YL+ E+ L+++L++ + + + +L
Sbjct: 73 HRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQK------LDQQRTATIIQELSDA 126
Query: 115 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 174
L +CH +V+HRD+KP+NLL+ G +K++DFG + P TL Y PE +
Sbjct: 127 LTYCHEKKVIHRDIKPENLLLGLNGEVKISDFGW--SVHTPSLRRKTMCGTLDYLPPE-M 183
Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 234
+ K Y+ VD+W +G + E++ + F + + RI +
Sbjct: 184 IAQKPYNEMVDLWCIGVLCYELLVGKPPFESSTSSETYRRIRQV---------------- 227
Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
D+K F VP +D L+S++L Y P++R+S L HP+ ++ ++ V
Sbjct: 228 DFK----------FPSSVPAGAQD---LISKLLRYHPSERLSLAQVLKHPWVREHSRRV 273
>ref|NP_034920.1| (NM_010790) maternal embryonic leucine zipper kinase [Mus musculus]
Length = 643
Score = 109 bits (273), Expect = 6e-25
Identities = 89/298 (29%), Positives = 134/298 (44%), Gaps = 39/298 (13%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
++ ++ E IG G + V A + LTGE+VA+K + + +P EI LK L H
Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKT-EIDALKSLRH 66
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
+I +L V+ T+NK+++V E+ + F + + + Q+L +A+ HS
Sbjct: 67 QHICQLYHVLETKNKIFMVLEYCPGG-ELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT----LWYRAPEILLG 176
HRDLKP+NLL + +KL DFGL P + + T L Y APE++ G
Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLC---AKPKGNKDYHLQTCCGSLAYAAPELIQG 182
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
Y + D+WS+G + ++ F D+ + +I R
Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG------------------ 224
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF-FQDVTKPV 293
K PKW L LL QML DP KRIS + L HP+ QD + PV
Sbjct: 225 KYEVPKW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPV 271
>ref|NP_035022.1| (NM_010892) NIMA - related expressed kinase 2; NIMA-related
expressed kinase 2 [Mus musculus]
Length = 443
Score = 108 bits (271), Expect = 1e-24
Identities = 73/221 (33%), Positives = 110/221 (49%), Gaps = 14/221 (6%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E+++ + IG G+YG K R K G+++ K++ + TE + E++LL+EL H
Sbjct: 5 VEDYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKH 64
Query: 61 PNIVKLLDVI--HTENKLYLVFEFLH-QDLKKFMDASALTG--IPLPLIKSYLFQLLQGL 115
PNIV+ D I T LY+V E+ DL + + + + QL L
Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGTKDRQYLEEEFVLRVMTQLTLAL 124
Query: 116 AFCH-----SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
CH H VLHRDLKP N+ ++++ +KL DFGLAR V T +Y +
Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQ 211
PE + C Y+ DIWSL C+ E+ AL P + +Q
Sbjct: 185 PE-QMSCLSYNEKSDIWSLACLLYELC---ALMPPFTAFNQ 221
>ref|NP_035978.1| (NM_011848) NIMA-related expressed kinase 3 [Mus musculus]
Length = 509
Score = 107 bits (266), Expect = 4e-24
Identities = 68/216 (31%), Positives = 108/216 (49%), Gaps = 5/216 (2%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
M+N+ + IG+G++G + + + A+K+IRL + T+ +E LL ++ H
Sbjct: 1 MDNYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRL---LKSDTQTSRKEAVLLAKMKH 57
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
PNIV + E LY+V E+ DL + + P I ++ Q+ G+ H
Sbjct: 58 PNIVAFKESFEAEGYLYIVMEYCDGGDLMQRIKQQKGNLFPEDTILNWFIQICLGVNHIH 117
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
RVLHRD+K +N+ + G +KL DFG AR P+ V T +Y PEI Y
Sbjct: 118 KRRVLHRDIKSKNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPY 177
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRI 215
+ + DIWSLGCI E+ + F +S + + +I
Sbjct: 178 NNKS-DIWSLGCILYELCALKHPFQANSWKNLILKI 212
>ref|NP_032667.1| (NM_008641) microtubule associated testis specific serine/threonine
protein kinase [Mus musculus]
Length = 1734
Score = 106 bits (265), Expect = 5e-24
Identities = 84/308 (27%), Positives = 141/308 (45%), Gaps = 55/308 (17%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNH 60
E+F+ ++ I G YG V+ R+K T + A+KKI + + A E +L +
Sbjct: 451 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 510
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALT----GIPLPLIKSYLFQLLQGLA 116
P +V + T+ L +V E++ D + L +P+ +++ Y + + L
Sbjct: 511 PFVVSMFCSFETKRHLCMVMEYVEGG-----DCATLLKNIGALPVDMVRLYFAETVLALE 565
Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE-------------- 162
+ H++ ++HRDLKP NLLI + G IKL DFGL++ + + T +E
Sbjct: 566 YLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQ 625
Query: 163 -VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT 221
T Y APE++L + Y VD W++G I E + F GD+ + ++
Sbjct: 626 VCGTPEYIAPEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI----- 679
Query: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281
DE+VWP + +PP D + L S++LH +P +R+ +A
Sbjct: 680 SDEIVWP------------------EGDDALPP---DAQDLTSKLLHQNPLERLGTSSAY 718
Query: 282 ---AHPFF 286
HPFF
Sbjct: 719 EVKQHPFF 726
>ref|NP_032953.1| (NM_008927) mitogen activated protein kinase kinase 1; MAP kinase
kinase 1; protein kinase, mitogen activated, kinase 1,
p45 [Mus musculus]
Length = 393
Score = 104 bits (260), Expect = 2e-23
Identities = 72/217 (33%), Positives = 119/217 (54%), Gaps = 12/217 (5%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
++F+K+ ++G G GVV+K +K +G V+A K I L+ + + + IRE+ +L E N P
Sbjct: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 124
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHS 120
IV +++ ++ + E H D G IP ++ +++GL +
Sbjct: 125 YIVGFYGAFYSDGEISICME--HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 182
Query: 121 -HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEILLGCK 178
H+++HRD+KP N+L+N+ G IKL DFG++ G + + + V T Y +PE L G
Sbjct: 183 KHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQG-T 238
Query: 179 YYSTAVDIWSLGCIFAEM-VTRRALFPGDS-EIDQLF 213
+YS DIWS+G EM V R + P D+ E++ LF
Sbjct: 239 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLF 275
>ref|NP_035293.1| (NM_011163) eukaryotic translation initiation factor 2 alpha kinase
2; eIF-2 alpha; IFN- type I-induced and dsRNA-activated
kinase; IFN-induced and double-stranded RNA-activated
kinase; INF type I-induced and dsRNA-activated kinase;
INF-induced and dou>
Length = 515
Score = 104 bits (259), Expect = 2e-23
Identities = 70/212 (33%), Positives = 115/212 (54%), Gaps = 24/212 (11%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
+F+ +E+IG G +G V+KA++++ G+ A+K+++ +TE A E+ L ELNH N
Sbjct: 241 DFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEK------AEHEVQALAELNHVN 294
Query: 63 IVKL--------LDVIHTENK--------LYLVFEFLHQD-LKKFMDASALTGIPLPLIK 105
IV+ D H+ + L++ EF + L+++M + + LI
Sbjct: 295 IVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALIL 354
Query: 106 SYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT 165
Q++ G+ + HS ++HRDLKP N+ + E IK+ DFGLA A ++ T T
Sbjct: 355 DLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGT 414
Query: 166 LWYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197
L Y +PE L K+Y VDI++LG I AE++
Sbjct: 415 LQYMSPEQLF-LKHYGKEVDIFALGLILAELL 445
>ref|NP_032885.1| (NM_008859) protein kinase C, theta [Mus musculus]
Length = 707
Score = 103 bits (257), Expect = 4e-23
Identities = 82/300 (27%), Positives = 140/300 (46%), Gaps = 50/300 (16%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET--EGVPSTAIREISLLKEL 58
+++F + +G+G++G V+ A K T + A+K ++ D + V T + + L
Sbjct: 377 IDDFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 436
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQ 110
HP + + T+ L+ V E+L+ Q KF D S T Y +
Sbjct: 437 EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKF-DLSRAT--------FYAAE 487
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
++ GL F HS +++RDLK N+L++ +G IK+ADFG+ + + T Y A
Sbjct: 488 VILGLQFLHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIA 547
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
PEILLG K Y+ +VD WS G + EM+ ++ F G E ++LF R
Sbjct: 548 PEILLGQK-YNHSVDWWSFGVLVYEMLIGQSPFHGQDE-EELFHSIRM------------ 593
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL-AHPFFQDV 289
P +P+W L+ + + LL ++ +P KR+ + + HP F+++
Sbjct: 594 -----DNPFYPRW-----------LEREAKDLLVKLFVREPEKRLGVRGDIRQHPLFREI 637
>ref|NP_033936.1| (NM_009806) calcium/calmodulin-dependent serine protein kinase [Mus
musculus]
Length = 924
Score = 103 bits (257), Expect = 4e-23
Identities = 83/296 (28%), Positives = 143/296 (48%), Gaps = 40/296 (13%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAI-REISLLKELNH 60
++ E IG+G + VV + N+ TG+ A+K + + T + G+ + + RE S+ L H
Sbjct: 12 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 71
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-----DLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
P+IV+LL+ ++ LY+VFEF+ ++ K DA + + Y+ Q+L+ L
Sbjct: 72 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFV--YSEAVASHYMRQILEAL 129
Query: 116 AFCHSHRVLHRDLKPQNLLI---NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
+CH + ++HRD+KP +L+ +KL FG+A G V T + APE
Sbjct: 130 RYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE 189
Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
++ + Y VD+W G I +++ F G E R+F E + G
Sbjct: 190 VVKR-EPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLF-------EGIIKG--- 233
Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
YK + +W+ + E + L+ +ML DP +RI+ AL HP+ ++
Sbjct: 234 --KYKMNPRQWSH---------ISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 278
>ref|NP_035233.1| (NM_011103) protein kinase C, delta; protein kinase C[d] [Mus
musculus]
Length = 674
Score = 102 bits (255), Expect = 7e-23
Identities = 82/300 (27%), Positives = 138/300 (45%), Gaps = 50/300 (16%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTET--EGVPSTAIREISLLKEL 58
+ENF + +G+G++G V A K + A+K ++ D + V T + + L
Sbjct: 344 LENFTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAW 403
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQ 110
P + L+ T++ L+ V EFL+ QD +F L Y +
Sbjct: 404 ESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRF---------ELYRATFYAAE 454
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
++ GL F HS +++RDLK N++++ +G IK+ADFG+ + + T Y A
Sbjct: 455 IICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIA 514
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
PEIL G K YS +VD WS G + EM+ ++ F GD E D+LF R
Sbjct: 515 PEILQGLK-YSFSVDWWSFGVLLYEMLIGQSPFHGDDE-DELFESIRV------------ 560
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL-AHPFFQDV 289
P +P+W + ++ + ++ ++ DP+KR+ + HPFF+ +
Sbjct: 561 -----DTPHYPRW-----------ITKESKDIMEKLFERDPDKRLGVTGNIRIHPFFKTI 604
>ref|NP_075627.1| (NM_023138) mitogen activated protein kinase kinase 2; MAP kinase
kinase 2; protein kinase, mitogen activated, kinase 2,
p45; MAP kinase/Erk kinase [Mus musculus]
Length = 401
Score = 102 bits (254), Expect = 9e-23
Identities = 69/210 (32%), Positives = 114/210 (53%), Gaps = 18/210 (8%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
++F+++ ++G G GVV KAR++ +G ++A K I L+ + V + IRE+ +L E N P
Sbjct: 70 DDFERISELGAGNGGVVTKARHRPSGFIMARKLIHLEIKP-AVRNQIIRELQVLHECNSP 128
Query: 62 NIVKLLDVIHTENKLYLVFEF-----LHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116
IV +++ ++ + E L Q LK+ IP ++ +L+GLA
Sbjct: 129 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKE------AKRIPEDILGKVSIAVLRGLA 182
Query: 117 FCHS-HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYRAPEIL 174
+ H+++HRD+KP N+L+N+ G IKL DFG++ G + + + V T Y +PE L
Sbjct: 183 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERL 239
Query: 175 LGCKYYSTAVDIWSLGCIFAEMVTRRALFP 204
G +YS DIWS+G E+ R P
Sbjct: 240 QG-THYSVQSDIWSMGLSLVELAIGRYPIP 268
>ref|NP_035915.1| (NM_011785) thymoma viral proto-oncogene 3; PKB gamma [Mus
musculus]
Length = 479
Score = 102 bits (253), Expect = 1e-22
Identities = 84/295 (28%), Positives = 137/295 (45%), Gaps = 37/295 (12%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELN 59
M +F ++ +G+GT+G V R K +G+ A+K ++ + + + + E +LK
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
HP + L T+++L V E+++ + F S + Y +++ L + H
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGG-ELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
S ++++RDLK +NL+++ +G IK+ DFGL + T T Y APE+L
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLED-ND 322
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
Y AVD W LG + EM+ R F + + ++LF + M D K
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPF-YNQDHEKLFELI---------------LMEDIK-- 364
Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289
FP+ L D +SLLS +L DPNKR+ AK + H FF V
Sbjct: 365 FPR-----------TLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGV 408
>ref|NP_061371.1| (NM_018883) calcium/calmodulin-dependent protein kinase kinase 1,
alpha; calcium calmodulin dependent protein kinase
kinase alpha [Mus musculus]
Length = 505
Score = 101 bits (252), Expect = 2e-22
Identities = 86/326 (26%), Positives = 141/326 (42%), Gaps = 64/326 (19%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-----------------RLDTETEG 43
+ ++ +IG+G YGVV A N+ A+K + R T+G
Sbjct: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQG 184
Query: 44 VPSTAI-------REISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQDLKKFMDAS 94
P+ + +I++LK+L+H N+VKL++V+ E+ LYLVF+ L + M+
Sbjct: 185 GPAKQLLPLERVYHDIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 242
Query: 95 ALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGV 154
P + YL ++ GL + H +++HRD+KP NLL+ +G +K+ADFG++ F
Sbjct: 243 CDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 302
Query: 155 PVRTYTHEVVTLWYRAPEIL--LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQL 212
+ T + APE + G + A+D+W+ G V + F ID
Sbjct: 303 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-----IDDY 357
Query: 213 FRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPN 272
+ VV+P P + ED + L+ +ML +P
Sbjct: 358 ILTLHRKIKNEAVVFP----------------------EEPEVSEDSKDLILRMLDKNPE 395
Query: 273 KRISAKAALAHPFFQDVTK----PVP 294
RI HP+ VTK P+P
Sbjct: 396 TRIGVSDIKLHPW---VTKHGEEPIP 418
>ref|NP_035234.1| (NM_011104) protein kinase C, epsilon [Mus musculus]
Length = 737
Score = 101 bits (251), Expect = 2e-22
Identities = 84/306 (27%), Positives = 140/306 (45%), Gaps = 56/306 (18%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58
++ F ++ +G+G++G V A K EV A+K ++ D + + V T + L
Sbjct: 405 LDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALAR 464
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQ 110
HP + +L T+++L+ V E+++ Q +KF + P + Y +
Sbjct: 465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE---------PRSRFYAAE 515
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 170
+ L F H H V++RDLK N+L++ EG KLADFG+ + + T T T Y A
Sbjct: 516 VTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIA 575
Query: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 230
PEIL + Y +VD W+LG + EM+ + F D+E D I D+V+
Sbjct: 576 PEILQELE-YGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH-----DDVL---- 625
Query: 231 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAA-------LAH 283
+P W L ++ S+L + +P+KR+ AA H
Sbjct: 626 ---------YPVW-----------LSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQH 665
Query: 284 PFFQDV 289
PFF+++
Sbjct: 666 PFFKEI 671
>ref|NP_035429.1| (NM_011299) ribosomal protein S6 kinase, 90kD, polypeptide 2 [Mus
musculus]
Length = 733
Score = 101 bits (251), Expect = 2e-22
Identities = 77/226 (34%), Positives = 120/226 (53%), Gaps = 12/226 (5%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTG----EVVALKKIRLDTETEGVPSTAIREISLLKELN 59
F+ ++ +G+G+YG V+ R K+TG ++ A+K ++ T + E +L E+N
Sbjct: 59 FELLKVLGQGSYGKVFLVR-KVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVN 117
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
HP IVKL TE KLYL+ +FL DL F S +K YL +L L
Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALALDHL 175
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEILLGC 177
H +++RDLKP+N+L++ EG IK+ DFGL++ A R Y+ T+ Y APE+ +
Sbjct: 176 HGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSF-CGTIEYMAPEV-VNR 233
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT-LGTP 222
+ ++ + D WS G + EM+T F G + + I + LG P
Sbjct: 234 RGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMP 279
Score = 86.3 bits (212), Expect = 7e-18
Identities = 77/290 (26%), Positives = 126/290 (42%), Gaps = 37/290 (12%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ ++ E IG G+Y V + +K T A+K I +++ PS I LL+ HP
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDAEYAVKII---DKSKRDPSEEIE--ILLRYGQHP 467
Query: 62 NIVKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
NI+ L DV +YLV E + + L + + + L+ + + + + H
Sbjct: 468 NIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREA---SDVLYTIARTMDYLH 524
Query: 120 SHRVLHRDLKPQNLLINTEG----AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 175
S V+HRDLKP N+L E +I++ DFG A+ T + APE+L
Sbjct: 525 SQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 584
Query: 176 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235
+ Y A D+WSLG + M+ F + TP+E++
Sbjct: 585 R-QGYDAACDVWSLGILLYTMLAGFTPFANGPD-----------DTPEEIL--ARIGSGK 630
Query: 236 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
Y S W + + + ++S+MLH DP +R++A L HP+
Sbjct: 631 YALSGGNW---------DSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPW 671
>ref|NP_067460.1| (NM_021485) ribosomal protein S6 kinase, 70kD, polypeptide 2; S6
kinase 2 [Mus musculus]
Length = 485
Score = 100 bits (249), Expect = 4e-22
Identities = 86/305 (28%), Positives = 139/305 (45%), Gaps = 59/305 (19%)
Query: 4 FQKVEKIGEGTYGVVYKARNKL---TGEVVALKKIRLDTETEGVPSTAIR--EISLLKEL 58
F+ + +G+G YG V++ R G++ A+K +R TA E ++L+ +
Sbjct: 67 FELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESV 126
Query: 59 NHPNIVKLLDVIHTENKLYLVFE-------FLHQDLKK-FMDASALTGIPLPLIKSYLFQ 110
HP IV+L T KLYL+ E F H + + F++ +A YL +
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACF---------YLAE 177
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVV-TLWYR 169
+ L HSH +++RDLKP+N++++++G IKL DFGL + + TH T+ Y
Sbjct: 178 ITLALGHLHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKE-SIHEGAITHTFCGTIEYM 236
Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
APEIL+ ++ AVD WSLG + +M+T F ++ + +I + G
Sbjct: 237 APEILVRTG-HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIK-----------G 284
Query: 230 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHP 284
+P Y L D R L + L +P +RI A HP
Sbjct: 285 KLVLPPY------------------LTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHP 326
Query: 285 FFQDV 289
FF+ +
Sbjct: 327 FFRHI 331
>ref|NP_056570.1| (NM_015755) hormonally upregulated Neu-associated kinase [Mus
musculus]
Length = 714
Score = 100 bits (249), Expect = 4e-22
Identities = 71/203 (34%), Positives = 109/203 (52%), Gaps = 24/203 (11%)
Query: 9 KIGEGTYGVVYKARNKLTGEVVALKKI---RLDTETEGVPSTAIREISLLKELNHPNIVK 65
K+GEG++ V + + LTGE VA+K I R +T V RE + + + HPNI +
Sbjct: 67 KLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTY-VTKNLRREGQIQQMIRHPNITQ 125
Query: 66 LLDVIHTENKLYLVFEF------LHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
LLD++ TEN YLV E +H+ + K+ +A A + Y+ QL+ +
Sbjct: 126 LLDILETENSYYLVMELCPGGNLMHKIYEKKRLDEAEA---------RRYIRQLISAVEH 176
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT--YTHEVVTLWYRAPEILL 175
H V+HRDLK +NLL++ + IKL DFGL+ G+ + ++ + + Y APE LL
Sbjct: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPE-LL 235
Query: 176 GCKYYSTAVDIWSLGCIFAEMVT 198
K Y +D+WS+G M+T
Sbjct: 236 ARKKYGPKIDVWSIGVNMYAMLT 258
>ref|NP_031621.1| (NM_007595) calcium/calmodulin-dependent protein kinase II, beta;
CaMK II [Mus musculus]
Length = 542
Score = 100 bits (248), Expect = 5e-22
Identities = 87/287 (30%), Positives = 132/287 (45%), Gaps = 30/287 (10%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ +Q E+IG+G + VV + TG A K I + RE + + L H
Sbjct: 12 DEYQLYEEIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
NIV+L D I E YLVF+ + + F D A + Q+L+ + CH
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 130
Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
V+HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L +
Sbjct: 131 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-E 189
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
Y VDIW+ G I ++ F D + +L++ + G P
Sbjct: 190 AYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKA----------GAYDFPS--- 235
Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
P+W V P + ++L++QML +P KRI+A AL HP+
Sbjct: 236 --PEW-----DTVTP----EAKNLINQMLTINPAKRITAHEALKHPW 271
>ref|NP_033032.1| (NM_009006) mitogen activated protein kinase kinase kinase kinase
2; RAB8 interacting protein [Mus musculus]
Length = 821
Score = 99.8 bits (247), Expect = 6e-22
Identities = 64/200 (32%), Positives = 109/200 (54%), Gaps = 11/200 (5%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ F+ ++++G GTYG VYKAR+ +T E+ A+K ++LD + S+ +EI++L+E HP
Sbjct: 14 DRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDD--ISSLQQEITILRECRHP 71
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLP--LIKSYLFQLLQGLAFC 118
N+V + ++L++ EF L++ A+ PL I + L+GL
Sbjct: 72 NVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG----PLEERQIAYVCREALKGLHHL 127
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
HS +HRD+K NLL+ +G +KLADFG++ V + T ++ APE+ +
Sbjct: 128 HSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVER 187
Query: 179 Y--YSTAVDIWSLGCIFAEM 196
Y+ D+W+LG E+
Sbjct: 188 KGGYNELCDVWALGITAIEL 207
>ref|NP_067512.1| (NM_021537) serine/threonine kinase 25 (yeast); Ste20-like kinase;
serine/threonine kinase 25 (Ste20, yeast homolog); Yeast
Sps1/Ste20-related kinase 1 [Mus musculus]
Length = 426
Score = 99.4 bits (246), Expect = 8e-22
Identities = 88/300 (29%), Positives = 139/300 (46%), Gaps = 42/300 (14%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
E F K+++IG+G++G VYK + T EVVA+K I L+ E E +EI++L + + P
Sbjct: 18 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLE-EAEDEIEDIQQEITVLSQCDSP 76
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGI-PLPLIKSY----LFQLLQGLA 116
I + KL+++ E+L SAL + P PL ++Y L ++L+GL
Sbjct: 77 YITRYFGSYLKSTKLWIIMEYLG-------GGSALDLLKPGPLEETYIATILREILKGLD 129
Query: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
+ HS R +HRD+K N+L++ +G +K+ADFG+A V T ++ APE++
Sbjct: 130 YLHSERKIHRDIKAANVLLSEQGDVKMADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
Y A DIWSLG E+ P +S++ + R+ + + G S P
Sbjct: 190 SAYDFKA-DIWSLGITAIELAKGE---PPNSDLHPM-RVLFLIPKNNPPTLEGHHSKP-- 242
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
+ + L+ DP R +AK L H F TK L
Sbjct: 243 ----------------------FKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFL 280
>ref|NP_031717.1| (NM_007691) checkpoint kinase 1 homolog (S. pombe); rad27 homolog
(S.pombe) [Mus musculus]
Length = 476
Score = 99.4 bits (246), Expect = 8e-22
Identities = 62/199 (31%), Positives = 103/199 (51%), Gaps = 4/199 (2%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
+E++ V+ +GEG YG V A N++T + VA+K + + + P +EI + K L+H
Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRITEQAVAVKIVDMKRAID-CPQNIKKEICINKMLSH 64
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
N+VK + YL E+ + F G+P + + QL+ G+ + H
Sbjct: 65 ENVVKFYGHRREGHIQYLFLEYCSGG-ELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHG 123
Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCK 178
+ HRD+KP+NLL++ +K++DFGLA F R TL Y APE+L +
Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRHNNRERLLNKMCGTLPYVAPELLKRKE 183
Query: 179 YYSTAVDIWSLGCIFAEMV 197
+++ VD+WS G + M+
Sbjct: 184 FHAEPVDVWSCGIVLTAML 202
>ref|NP_031738.1| (NM_007712) CDC-like kinase 2 [Mus musculus]
Length = 499
Score = 99.0 bits (245), Expect = 1e-21
Identities = 93/344 (27%), Positives = 150/344 (43%), Gaps = 60/344 (17%)
Query: 2 ENFQKVEKIGEGTYG-VVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
E ++ V +GEGT G VV ++ G VALK I+ E A EI++L+++N
Sbjct: 160 ERYEIVSTLGEGTSGRVVQCVDHRRGGTRVALKIIK---NVEKYKEAARLEINVLEKINE 216
Query: 61 PN------IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 114
+ V++ D + + FE L F+ + P+ ++ FQL Q
Sbjct: 217 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQA 276
Query: 115 LAFCHSHRVLHRDLKPQNLL-INTE------------------GAIKLADFGLARAFGVP 155
+ F H +++ H DLKP+N+L +N++ A+++ DFG A
Sbjct: 277 VKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA------ 330
Query: 156 VRTYTHE-----VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEID 210
T+ HE V T YRAPE++L +S D+WS+GCI E LF +
Sbjct: 331 --TFDHEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 387
Query: 211 QLFRIFRTLG-TPDEVV---------WPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGR 260
L + R LG P ++ + G D S ++ R++ + L +
Sbjct: 388 HLAMMERILGPVPSRMIRKTRKQKYFYRGRLDW-DENTSAGRYVRENCKPLRRYLTSEAE 446
Query: 261 ------SLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298
L+ ML Y+P KR++ AL HPFF + P+ +L
Sbjct: 447 DHHQLFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKL 490
>ref|NP_076302.1| (NM_023813) calcium/calmodulin-dependent protein kinase II, delta;
CaMK II [Mus musculus]
Length = 478
Score = 98.6 bits (244), Expect = 1e-21
Identities = 84/287 (29%), Positives = 133/287 (46%), Gaps = 30/287 (10%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
+ +Q E++G+G + VV + TG+ A K I + RE + + L HP
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
NIV+L D I E YLVF+ + + F D A + Q+L+ + CH +
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGG-ELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
Query: 122 RVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
++HRDLKP+NLL+ ++ A+KLADFGLA + + T Y +PE+L
Sbjct: 131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-D 189
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
Y VD+W+ G I ++ F D + +L++ + G P
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQIKA----------GAYDFPS--- 235
Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
P+W V P + + L+++ML +P KRI+A AL HP+
Sbjct: 236 --PEW-----DTVTP----EAKDLINKMLTINPAKRITASEALKHPW 271
>ref|NP_033495.1| (NM_009469) Unc-51 like kinase 1 (C. elegans); Unc-51 like kinase 1
[Mus musculus]
Length = 1051
Score = 98.2 bits (243), Expect = 2e-21
Identities = 68/218 (31%), Positives = 111/218 (50%), Gaps = 16/218 (7%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEV-VALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
F + + IG G + VV+K R++ ++ VA+K I + +EI +LKEL H N
Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLG-KEIKILKELKHEN 74
Query: 63 IVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
IV L D N +YLV E+ + DL ++ + + ++ +L Q+ + HS
Sbjct: 75 IVALYDFQEMANSVYLVMEYCNGGDLADYLHT--MRTLSEDTVRLFLQQIAGAMRLLHSK 132
Query: 122 RVLHRDLKPQNLLINTEGA---------IKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
++HRDLKPQN+L++ G +K+ADFG AR + T + Y APE
Sbjct: 133 GIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAAT-LCGSPMYMAPE 191
Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEID 210
+++ ++Y D+WS+G I + +T +A F S D
Sbjct: 192 VIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 228
>ref|NP_038909.1| (NM_013881) Unc-51 like kinase 2 (C. elegans) [Mus musculus]
Length = 1037
Score = 97.4 bits (241), Expect = 3e-21
Identities = 90/311 (28%), Positives = 141/311 (44%), Gaps = 60/311 (19%)
Query: 6 KVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 64
K + +G G + VV++ R++ T VA+K I ++ +EI +LKEL H NIV
Sbjct: 11 KRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLG-KEIKILKELQHENIV 69
Query: 65 KLLDVIHTENKLYLVFEFLH-QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123
L DV N ++LV E+ + DL ++ A + I+ +L Q+ + HS +
Sbjct: 70 ALYDVQELPNSVFLVMEYCNGGDLADYLQAKGT--LSEDTIRVFLHQIAAAMRILHSKGI 127
Query: 124 LHRDLKPQNLLI--------NTEG-AIKLADFGLARAFGVPVRTYTHE---VVTL----W 167
+HRDLKPQN+L+ N G IK+ADFG AR Y H TL
Sbjct: 128 IHRDLKPQNILLSYANRRKSNVSGIRIKIADFGFAR--------YLHSNTMAATLCGSPM 179
Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 227
Y APE+++ ++Y D+WS+G + + + + F +S D R+F
Sbjct: 180 YMAPEVIMS-QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD--LRMF----------- 225
Query: 228 PGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
PS P+ + P L +LL +L + R+ +A +HPF +
Sbjct: 226 --YEKNRSLMPSIPR-------ETSPYL----ANLLLGLLQRNQKDRMDFEAFFSHPFLE 272
Query: 288 DV----TKPVP 294
V + PVP
Sbjct: 273 QVPVKKSCPVP 283
>ref|NP_034848.1| (NM_010718) LIM motif-containing protein kinase 2 [Mus musculus]
Length = 638
Score = 96.7 bits (239), Expect = 5e-21
Identities = 67/214 (31%), Positives = 112/214 (52%), Gaps = 32/214 (14%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKK-IRLDTETEGVPSTAIREISLLKELNHPNIVKL 66
E +G+G +G K +K TG+V+ +K+ IR D ET+ T + E+ +++ L+HPN++K
Sbjct: 335 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ---KTFLTEVKVMRSLDHPNVLKF 391
Query: 67 LDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQ--LLQGLAFCHSHRV 123
+ V++ + KL L+ E++ LK F+ + P P + F + G+A+ HS +
Sbjct: 392 IGVLYKDKKLNLLTEYIEGGTLKDFLRSVD----PFPWQQKVRFAKGISSGMAYLHSMCI 447
Query: 124 LHRDLKPQNLLINTEGAIKLADFGLARAF-----GVPVRTYTHEVVTL------------ 166
+HRDL N LI + + +ADFGL+R PV T + TL
Sbjct: 448 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVV 507
Query: 167 ---WYRAPEILLGCKYYSTAVDIWSLGCIFAEMV 197
++ APE+L G K Y VD++S G + E++
Sbjct: 508 GNPYWMAPEMLNG-KSYDETVDVFSFGIVLCEII 540
>ref|NP_033923.1| (NM_009793) calcium/calmodulin-dependent protein kinase IV;
Ca2+/calmodulin-dependent protein kinase type IV/Gr [Mus
musculus]
Length = 469
Score = 96.7 bits (239), Expect = 5e-21
Identities = 82/286 (28%), Positives = 132/286 (45%), Gaps = 36/286 (12%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
F+ ++G G +VY+ + K T + ALK ++ + + V + EI +L L+HPNI
Sbjct: 42 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLSHPNI 97
Query: 64 VKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPL-IKSYLFQLLQGLAFCHSHR 122
+KL ++ T ++ LV E + + D G + + Q+L+ +A+ H +
Sbjct: 98 IKLKEIFETPTEISLVLELVTGG--ELFDRIVEKGYYSERDARDAVKQILEAVAYLHENG 155
Query: 123 VLHRDLKPQNLLINT---EGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
++HRDLKP+NLL T + +K+ADFGL++ V T T Y APEIL GC
Sbjct: 156 IVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKT-VCGTPGYCAPEILRGCA- 213
Query: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
Y VD+WS+G I + P E F R L +Y
Sbjct: 214 YGPEVDMWSVGII--TYILLCGFEPFYDERGDQFMFRRILNC-------------EYYFI 258
Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
P W + + + L+ +++ DP KR++ AL HP+
Sbjct: 259 SPWW---------DEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPW 295
>ref|NP_032606.1| (NM_008580) mitogen activated protein kinase kinase kinase 5; MEK
kinase 5 [Mus musculus]
Length = 1379
Score = 96.3 bits (238), Expect = 7e-21
Identities = 95/312 (30%), Positives = 146/312 (46%), Gaps = 50/312 (16%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
+G+GTYG+VY R+ +A+K+I P EI+L K L H NIV+ L
Sbjct: 693 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLH--EEIALHKHLKHKNIVQYLGS 750
Query: 70 IHTENKLYLVFEFLHQDLKKFMDASALTGI------PLP----LIKSYLFQLLQGLAFCH 119
+EN +F + + +L+ + PL I Y Q+L+GL + H
Sbjct: 751 F-SENCFIKIF-------MEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLH 802
Query: 120 SHRVLHRDLKPQNLLINT-EGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEIL-LG 176
++++HRD+K N+LINT G +K++DFG + R G+ T T TL Y APEI+ G
Sbjct: 803 DNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETF-TGTLQYMAPEIIDKG 861
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP-GVTSM-P 234
+ Y A DIWSLGC EM T + F LG P ++ G+ + P
Sbjct: 862 PRGYGKAADIWSLGCTIIEMATGKP-------------PFYELGEPQAAMFKVGMFKVHP 908
Query: 235 DYKPSFPKWARQDFSKVVPPLDEDGRS-----LLSQMLHYDPNK-----RISAKAALAHP 284
+ S A+ K P D D R+ L+ + L K ++SA + ++
Sbjct: 909 EIPESMSAEAKAFILKCFEP-DPDKRACANDLLIDEFLKVSSKKKKTQPKLSALSTGSNE 967
Query: 285 FFQDVTKPVPHL 296
+ + ++ PVP L
Sbjct: 968 YLRSISLPVPVL 979
>ref|NP_035209.1| (NM_011079) phosphorylase kinase gamma [Mus musculus]
Length = 388
Score = 96.3 bits (238), Expect = 7e-21
Identities = 88/308 (28%), Positives = 141/308 (45%), Gaps = 41/308 (13%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRL-------DTETEGVPSTAIREISL 54
EN++ E +G G VV + +K T + A+K I + E + + ++E+ +
Sbjct: 18 ENYEPKEILGRGVSSVVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDI 77
Query: 55 LKELN-HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQ 113
L++++ HPNI++L D T +LVF+ + + + F + + + + LL+
Sbjct: 78 LQKVSGHPNIIQLKDTYETNTFFFLVFDLMKRG-ELFDYLTEKVTLTEKETRKIMRALLE 136
Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173
+ H ++HRDLKP+N+L++ IKL DFG + P T Y APEI
Sbjct: 137 VICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQL-QPGEKLREVCGTPSYLAPEI 195
Query: 174 LL-----GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP 228
+ G Y VD+WS G I M T A P Q+ + ++
Sbjct: 196 IQCSMDDGHPGYGKEVDMWSTGVI---MYTLLAGSPPFWHRKQMLML--------RMIMD 244
Query: 229 GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
G Y+ P+W D+S V + L+S+ L P R SA+ ALAHPFFQ+
Sbjct: 245 G-----KYQFGSPEW--DDYSDTV-------KDLVSRFLVVQPQDRCSAEEALAHPFFQE 290
Query: 289 -VTKPVPH 295
V + V H
Sbjct: 291 YVVEEVRH 298
>ref|NP_114393.1| (NM_032004) serine/threonine protein kinase SSTK [Mus musculus]
Length = 273
Score = 95.9 bits (237), Expect = 9e-21
Identities = 73/209 (34%), Positives = 109/209 (51%), Gaps = 8/209 (3%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68
IGEG+Y V A +K VA+K + R + V RE+S+L+ + HP+IV + +
Sbjct: 18 IGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFE 77
Query: 69 VIHTEN-KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127
I N KLY+V E DL + + + IP + Q+ + + H H ++HRD
Sbjct: 78 FIEVCNGKLYIVMEAAATDLLQAVQRNGR--IPGSQARELFSQIAGAVRYLHDHHLVHRD 135
Query: 128 LKPQNLLINT-EGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVD 185
LK +N+L++ E +K+ DFG R A G P + T+ + Y +PE+LLG Y D
Sbjct: 136 LKCENVLLSPDERRVKITDFGFGRQAHGYPDLSTTY-CGSAAYASPEVLLGIPYDPKKYD 194
Query: 186 IWSLGCIFAEMVTRRALFPGDSEIDQLFR 214
+WSLG + MVT F DS+I L R
Sbjct: 195 VWSLGVVLYVMVTGCMPF-DDSDIAGLPR 222
>ref|NP_034847.1| (NM_010717) LIM-domain containing, protein kinase [Mus musculus]
Length = 647
Score = 95.9 bits (237), Expect = 9e-21
Identities = 59/207 (28%), Positives = 109/207 (52%), Gaps = 19/207 (9%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKK-IRLDTETEGVPSTAIREISLLKELNHPNIVKL 66
E +G+G +G K ++ TGEV+ +K+ IR D ET+ T ++E+ +++ L HPN++K
Sbjct: 343 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQ---RTFLKEVKVMRCLEHPNVLKF 399
Query: 67 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHR 126
+ V++ + +L + E++ + + + + P S+ + G+A+ HS ++HR
Sbjct: 400 IGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHR 459
Query: 127 DLKPQNLLINTEGAIKLADFGLA-------------RAFGVPVRTYTHEVV-TLWYRAPE 172
DL N L+ + +ADFGLA R+ P R + VV ++ APE
Sbjct: 460 DLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPYWMAPE 519
Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTR 199
++ G + Y VD++S G + E++ R
Sbjct: 520 MING-RSYDEKVDVFSFGIVLCEIIGR 545
>ref|NP_035979.1| (NM_011849) NIMA-related expressed kinase 4 [Mus musculus]
Length = 792
Score = 95.1 bits (235), Expect = 1e-20
Identities = 69/252 (27%), Positives = 112/252 (44%), Gaps = 12/252 (4%)
Query: 10 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDV 69
+G G+YG V +++ G+ +KK+ L + A +E LL +L HPNIV +
Sbjct: 12 VGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTYKES 71
Query: 70 IHT-ENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 127
+ LY+V F DL + + +P + + Q+ L + H +LHRD
Sbjct: 72 WEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPESQVVEWFVQIAMALQYLHEKHILHRD 131
Query: 128 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIW 187
LK QN+ + IK+ D G+AR + + T +Y +PE L K Y+ D+W
Sbjct: 132 LKTQNVFLTRTNIIKVGDLGIARVLENHGDMASTLIGTPYYMSPE-LFSNKPYNYKSDVW 190
Query: 188 SLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP---------DEVVWPGVTSMPDYKP 238
+LGC EM T + F ++RI P E++ ++ P+ +P
Sbjct: 191 ALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPKVYSTELAELIRTMLSRRPEERP 250
Query: 239 SFPKWARQDFSK 250
S RQ + K
Sbjct: 251 SVRSILRQPYIK 262
>ref|NP_064362.1| (NM_019978) double cortin and calcium/calmodulin-dependent protein
kinase-like 1; doublecortin-like kinase [Mus musculus]
Length = 756
Score = 94.4 bits (233), Expect = 3e-20
Identities = 84/292 (28%), Positives = 130/292 (43%), Gaps = 35/292 (11%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
E ++ IG+G + VV + + T ALK I+ ++ G E+S+L+ + HP
Sbjct: 404 ERYKVGRTIGDGNFAVVKECIERSTAREYALKIIK-KSKCRGKEHMIQNEVSILRRVKHP 462
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKS-YLFQLLQGLAFCHS 120
NIV L++ + +LYLV E + DA T S L+ L + + HS
Sbjct: 463 NIVLLIEEMDVPTELYLVMELVKGG--DLFDAITSTSKYTERDASGMLYNLASAIKYLHS 520
Query: 121 HRVLHRDLKPQNLLI----NTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176
++HRD+KP+NLL+ + ++KL DFGLA P+ T T Y APEI+
Sbjct: 521 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG---TPTYVAPEIIAE 577
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
Y VDIW+ G I ++ F FR G EV++ +
Sbjct: 578 TG-YGLKVDIWAAGVITYILLCG-------------FPPFRGSGDDQEVLFDQILMGQVD 623
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
PS P W + + + L++ ML + ++R SA L HP+ D
Sbjct: 624 FPS-PYWDN---------VSDSAKELINMMLLVNVDQRFSAVQVLEHPWVND 665
>ref|NP_035970.1| (NM_011840) mitogen activated protein kinase kinase 5; MAPK/ERK
kinese 5 [Mus musculus]
Length = 448
Score = 94.0 bits (232), Expect = 3e-20
Identities = 64/201 (31%), Positives = 104/201 (50%), Gaps = 17/201 (8%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67
+ +G G G VYKA + +G+++A+K I LD E + + E+ +L + + I+
Sbjct: 170 DTLGHGNGGTVYKAHHVPSGKILAVKVILLDITLE-LQKQIMSELEILYKCDSSYIIGFY 228
Query: 68 DVIHTENKLYLVFEFLHQDLKKFMDASALT---GIPLPLIKSYLFQLLQGLAFCHSHRVL 124
EN++ + EF MD +L IP ++ +++GL + S ++L
Sbjct: 229 GAFFVENRISICTEF--------MDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKIL 280
Query: 125 HRDLKPQNLLINTEGAIKLADFGLA-RAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 183
HRD+KP N+L+NT G +KL DFG++ + +TY V T Y APE + G + Y
Sbjct: 281 HRDVKPSNMLVNTGGQVKLCDFGVSTQLVNSIAKTY---VGTNAYMAPERISG-EQYGIH 336
Query: 184 VDIWSLGCIFAEMVTRRALFP 204
D+WSLG F E+ R +P
Sbjct: 337 SDVWSLGISFMELALGRFPYP 357
>ref|NP_057922.1| (NM_016713) mitogen-activated protein kinase kinase kinase kinase
6; Misshapen/NIKs-related kinase [Mus musculus]
Length = 1300
Score = 93.6 bits (231), Expect = 4e-20
Identities = 70/209 (33%), Positives = 106/209 (50%), Gaps = 23/209 (11%)
Query: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP-N 62
F+ VE +G GTYG VYK R+ TG++ A+K + + TE +EI++LK+ +H N
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV---TEDEEEEIKQEINMLKKYSHHRN 81
Query: 63 IVKLLDVI------HTENKLYLVFEFLHQ----DLKKFMDASALTGIPLPLIKSYLFQLL 112
I +++L+LV EF DL K +AL + I ++L
Sbjct: 82 IATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR---EIL 138
Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
+GLA H+H+V+HRD+K QN+L+ +KL DFG++ V + T ++ APE
Sbjct: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
Query: 173 ILLGC-----KYYSTAVDIWSLGCIFAEM 196
+ + C Y DIWSLG EM
Sbjct: 199 V-IACDENPDATYDYRSDIWSLGITAIEM 226
>ref|NP_064329.1| (NM_019945) syntrophin associated serine/threonine kinase;
syntrophin-associated serine-threonine protein kinase
[Mus musculus]
Length = 1566
Score = 93.6 bits (231), Expect = 4e-20
Identities = 81/311 (26%), Positives = 137/311 (44%), Gaps = 57/311 (18%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHP 61
+F ++ I G YG VY R++ T + A+KKI + + A E +L +P
Sbjct: 374 DFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 433
Query: 62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALT----GIPLPLIKSYLFQLLQGLAF 117
+V + T L +V E++ D + L +P+ + + Y + + L +
Sbjct: 434 FVVGMFCSFETRRHLCMVMEYVEGG-----DCATLLKNIGALPVEMARMYFAETVLALEY 488
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE--------------- 162
H++ ++HRDLKP NLLI + G IKL DFGL++ + + T +E
Sbjct: 489 LHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQV 548
Query: 163 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 222
T Y APE++L + Y VD W++G I E + F GD+ + ++
Sbjct: 549 CGTPEYIAPEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI-----S 602
Query: 223 DEVVWP-GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL 281
D+++WP G ++P D + L+S +L +P R+ A A
Sbjct: 603 DDILWPEGDEALP----------------------TDAQLLISSLLQTNPLVRLGAGGAF 640
Query: 282 ---AHPFFQDV 289
H FF+D+
Sbjct: 641 EVKQHTFFRDL 651
>ref|NP_573483.1| (NM_133220) serine/threonine protein kinase CISK [Mus musculus]
Length = 496
Score = 93.6 bits (231), Expect = 4e-20
Identities = 67/199 (33%), Positives = 105/199 (52%), Gaps = 8/199 (4%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALK----KIRLDTETEGVPSTAIREISLLKEL 58
+F ++ IG+G++G V A+ KL G+ A+K KI L+ + E A R + LLK +
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRK-EQKHIMAERNV-LLKNV 218
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
HP +V L T KLY V +F++ + F P P + Y ++ L +
Sbjct: 219 KHPFLVGLHYSFQTTEKLYFVLDFVNGG-ELFFHLQRERSFPEPRARFYAAEIASALGYL 277
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
HS ++++RDLKP+N+L+++ G + L DFGL + T T T Y APE++
Sbjct: 278 HSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337
Query: 179 YYSTAVDIWSLGCIFAEMV 197
Y +T VD W LG + EM+
Sbjct: 338 YDNT-VDWWCLGAVLYEML 355
>ref|NP_036170.1| (NM_012040) pregnancy upregulated non-ubiquitously expressed CaM
kinase; calcium/calmodulin-dependent protein kinase 1,
beta [Mus musculus]
Length = 343
Score = 92.0 bits (227), Expect = 1e-19
Identities = 85/290 (29%), Positives = 129/290 (44%), Gaps = 55/290 (18%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67
EK+G G + V A+ + + +VALK I G + EI++L+ ++HPNIV L
Sbjct: 19 EKLGSGAFSEVMLAQERGSAHLVALKCIPKKA-LRGKEALVENEIAVLRRISHPNIVALE 77
Query: 68 DVIHTENKLYLVFE----------FLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
DV + + LYL E + + DAS L G Q+L +++
Sbjct: 78 DVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVG-----------QVLGAVSY 126
Query: 118 CHSHRVLHRDLKPQNLLINT---EGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEI 173
HS ++HRDLKP+NLL T + I ++DFGL++ G + T T Y APE
Sbjct: 127 LHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGT---ACGTPGYVAPE- 182
Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233
LL K Y AVD+W+LG I ++ F +S+ + +I R
Sbjct: 183 LLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRA--------------- 227
Query: 234 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAH 283
Y+ P W + E + + +L DP KR + + AL H
Sbjct: 228 -SYEFDSPFW---------DDISESAKDFIRHLLERDPQKRFTCQQALQH 267
>ref|NP_031460.1| (NM_007434) thymoma viral proto-oncogene 2 [Mus musculus]
Length = 481
Score = 92.0 bits (227), Expect = 1e-19
Identities = 78/298 (26%), Positives = 136/298 (45%), Gaps = 43/298 (14%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE-TEGVPSTAIREISLLKELN 59
M +F ++ +G+GT+G V R K TG A+K +R + + + + E +L+
Sbjct: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 208
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
HP + L T ++L V E+ + + F S + Y +++ L + H
Sbjct: 209 HPFLTALKYAFQTHDRLCFVMEYANGG-ELFFHLSRERVFTEDRARFYGAEIVSALEYLH 267
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLAR---AFGVPVRTYTHEVVTLWYRAPEILLG 176
S V++RD+K +NL+++ +G IK+ DFGL + + G ++T+ T Y APE+L
Sbjct: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCG---TPEYLAPEVLED 324
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
Y AVD W LG + EM+ R F + + ++LF + +E+ +P
Sbjct: 325 -NDYGRAVDWWGLGVVMYEMMCGRLPF-YNQDHERLFELI----LMEEIRFPRT------ 372
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDV 289
L + +SLL+ +L DP +R+ AK + H FF +
Sbjct: 373 ------------------LGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSI 412
>ref|NP_033123.1| (NM_009097) ribosomal protein S6 kinase polypeptide 1 [Mus
musculus]
Length = 724
Score = 91.3 bits (225), Expect = 2e-19
Identities = 65/197 (32%), Positives = 106/197 (52%), Gaps = 9/197 (4%)
Query: 4 FQKVEKIGEGTYGVVYKARNKL---TGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
F+ ++ +G+G++G V+ R +G + A+K ++ T E +L ++NH
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 121
Query: 61 PNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
P +VKL TE KLYL+ +FL DL F S +K YL +L GL H
Sbjct: 122 PFVVKLHYAFQTEGKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALGLDHLH 179
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLAR-AFGVPVRTYTHEVVTLWYRAPEILLGCK 178
S +++RDLKP+N+L++ EG IKL DFGL++ A + Y+ T+ Y APE+ + +
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF-CGTVEYMAPEV-VNRQ 237
Query: 179 YYSTAVDIWSLGCIFAE 195
++ + D WS G + +
Sbjct: 238 GHTHSADWWSYGVLMGK 254
Score = 86.7 bits (213), Expect = 5e-18
Identities = 83/293 (28%), Positives = 124/293 (41%), Gaps = 43/293 (14%)
Query: 8 EKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLL 67
E IG G+Y V + +K T A+K I +++ PS I LL+ HPNI+ L
Sbjct: 411 ETIGVGSYSVCKRCVHKATNMEYAVKVI---DKSKRDPSEEIE--ILLRYGQHPNIITLK 465
Query: 68 DVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 125
DV +YLV E + + L K + + + L + + + + HS V+H
Sbjct: 466 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV---LHTISKTVEYLHSQGVVH 522
Query: 126 RDLKPQNLLINTEG----AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
RDLKP N+L E +++ DFG A+ T + APE+L + Y
Sbjct: 523 RDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR-QGYD 581
Query: 182 TAVDIWSLGCIFAEMVTRRALF---PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
DIWSLG + M+ F P D+ + L RI T W V+
Sbjct: 582 EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVS------- 634
Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291
E + L+S+MLH DP++R++AK L HP+ K
Sbjct: 635 ------------------ETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDK 669
>ref|NP_031854.1| (NM_007828) death-associated kinase 3; ZIP kinase [Mus musculus]
Length = 448
Score = 91.3 bits (225), Expect = 2e-19
Identities = 69/224 (30%), Positives = 119/224 (52%), Gaps = 15/224 (6%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVA---LKKIRLDTETEGVPSTAI-REISLLKE 57
++++ E++G G + +V K + K TG A +KK RL + GV I RE+S+L+E
Sbjct: 11 DHYEMGEELGSGQFAIVRKCQQKGTGMEYAAKFIKKRRLPSSRRGVSREEIEREVSILRE 70
Query: 58 LNHPNIVKLLDVIHTENKLYLVFEFLH-QDLKKFM-DASALTGIPLPLIKSYLFQLLQGL 115
+ HPNI+ L DV + + L+ E + +L F+ + +LT +L Q+L G+
Sbjct: 71 IRHPNIITLHDVFENKTDVVLILELVSGGELFDFLAEKESLTE---DEATQFLKQILDGV 127
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTHEVVTLWYRAP 171
+ HS R+ H DLKP+N+++ + A IKL DFG+A + + T + AP
Sbjct: 128 HYLHSKRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHRIEAG-SEFKNIFGTPEFVAP 186
Query: 172 EILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRI 215
EI + + D+WS+G I +++ + F G+++ + L I
Sbjct: 187 EI-VNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNI 229
>ref|NP_032883.1| (NM_008857) protein kinase C, lamda [Mus musculus]
Length = 586
Score = 90.9 bits (224), Expect = 3e-19
Identities = 80/298 (26%), Positives = 135/298 (44%), Gaps = 32/298 (10%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR--LDTETEGVPSTAIREISLLKEL 58
+++F + IG G+Y V R K T + A+K ++ L + E + + +
Sbjct: 241 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 300
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117
NHP +V L TE++L+ V E+++ DL M +P + Y ++ L +
Sbjct: 301 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARFYSAEISLALNY 358
Query: 118 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 177
H +++RDLK N+L+++EG IKL D+G+ + P T + T Y APEIL G
Sbjct: 359 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG- 417
Query: 178 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYK 237
+ Y +VD W+LG + EM+ R+ F I + PD+ + DY
Sbjct: 418 EDYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQ-------NTEDY- 459
Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAAL------AHPFFQDV 289
+ + ++ L S+L L+ DP +R+ HPFF++V
Sbjct: 460 --LFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNV 515
>ref|NP_035231.1| (NM_011101) protein kinase C, alpha [Mus musculus]
Length = 672
Score = 90.9 bits (224), Expect = 3e-19
Identities = 68/227 (29%), Positives = 116/227 (50%), Gaps = 27/227 (11%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT--ETEGVPSTAIREISLLKEL 58
+ +F + +G+G++G V A K T E+ A+K ++ D + + V T + + L
Sbjct: 336 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 395
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLH--------QDLKKFMDASALTGIPLPLIKSYLFQ 110
P + +L T ++LY V E+++ Q + KF + A+ Y +
Sbjct: 396 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVF---------YAAE 446
Query: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTHEVVTLW 167
+ GL F H +++RDLK N+++N+EG IK+ADFG+ + GV RT+ T
Sbjct: 447 ISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIADFGMCKEHMMDGVTTRTFCG---TPD 503
Query: 168 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFR 214
Y APEI + + Y +VD W+ G + EM+ + F G+ E D+LF+
Sbjct: 504 YIAPEI-IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE-DELFQ 548
>ref|NP_038759.1| (NM_013731) serum/glucocorticoid regulated kinase 2;
serum/glucocorticoid regulated kinase-like [Mus
musculus]
Length = 367
Score = 90.1 bits (222), Expect = 5e-19
Identities = 61/198 (30%), Positives = 99/198 (49%), Gaps = 6/198 (3%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAI---REISLLKELN 59
+F ++ IG+G YG V A+ K G A+K ++ + + I R + LLK +
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHIMAERNV-LLKNVR 92
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
HP +V L T KLY V ++++ + F P + Y ++ + + H
Sbjct: 93 HPFLVGLRYSFQTPEKLYFVLDYVNGG-ELFFHLQRERRFLEPRARFYTAEVASAIGYLH 151
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 179
S +++RDLKP+N+L++ +G + L DFGL + P T + T Y APE+L +
Sbjct: 152 SLNIIYRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRK-EP 210
Query: 180 YSTAVDIWSLGCIFAEMV 197
Y AVD W LG + EM+
Sbjct: 211 YDRAVDWWCLGAVLYEML 228
>ref|NP_032880.1| (NM_008854) protein kinase, cAMP dependent, catalytic, alpha; C
alpha [Mus musculus]
Length = 351
Score = 90.1 bits (222), Expect = 5e-19
Identities = 66/211 (31%), Positives = 111/211 (52%), Gaps = 8/211 (3%)
Query: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD--TETEGVPSTAIREISLLKEL 58
++ F +++ +G G++G V ++K +G A+K + + + + T + E +L+ +
Sbjct: 41 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHT-LNEKRILQAV 99
Query: 59 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
N P +VKL + LY+V E++ + F + P + Y Q++ +
Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVMEYVAGG-EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
HS +++RDLKP+NLLI+ +G I++ DFG A+ V RT+T T Y APEI+L K
Sbjct: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWT-LCGTPEYLAPEIILS-K 214
Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEI 209
Y+ AVD W+LG + EM F D I
Sbjct: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245
>ref|NP_032439.1| (NM_008413) Janus kinase 2 [Mus musculus]
Length = 1129
Score = 89.7 bits (221), Expect = 6e-19
Identities = 65/203 (32%), Positives = 102/203 (50%), Gaps = 16/203 (7%)
Query: 7 VEKIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
++++G+G +G V Y TGEVVA+KK++ TE REI +LK L H N
Sbjct: 852 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH--LRDFEREIEILKSLQHDN 909
Query: 63 IVKLLDVIHTENK--LYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
IVK V ++ + L L+ E+L + L+ ++ I + Y Q+ +G+ +
Sbjct: 910 IVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHK-ERIDHKKLLQYTSQICKGMEYLG 968
Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYRAPEILL 175
+ R +HRDL +N+L+ E +K+ DFGL + Y E WY AP+ L
Sbjct: 969 TKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APQSLT 1027
Query: 176 GCKYYSTAVDIWSLGCIFAEMVT 198
K +S A D+WS G + E+ T
Sbjct: 1028 ESK-FSVASDVWSFGVVLYELFT 1049
>ref|NP_036076.1| (NM_011946) mitogen activated protein kinase kinase kinase 2; MEK
kinase 2 [Mus musculus]
Length = 619
Score = 89.4 bits (220), Expect = 8e-19
Identities = 71/253 (28%), Positives = 122/253 (48%), Gaps = 25/253 (9%)
Query: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR------EISLLK 56
N++ + +G+G +G VY + TG +A+K+++ + E+ P T+ EI LLK
Sbjct: 355 NWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPES---PETSKEVNALECEIQLLK 411
Query: 57 ELNHPNIVKLLDVIHT-ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 115
L H IV+ + + K +F L A + + + Y Q+L+G+
Sbjct: 412 NLLHERIVQYYGCLRDPQEKTLSIFMELSPGGSIKDQLKAYGALTENVTRKYTRQILEGV 471
Query: 116 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF------GVPVRTYTHEVVTLWYR 169
+ HS+ ++HRD+K N+L ++ G IKL DFG ++ G +++ T T ++
Sbjct: 472 HYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTG---TPYWM 528
Query: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
+PE++ G + Y DIWS+ C EM+T + P +E + + IF+ P P
Sbjct: 529 SPEVISG-EGYGRKADIWSVACTVVEMLTEK---PPWAEFEAMAAIFKIATQPTNPKLPP 584
Query: 230 VTSMPDYKPSFPK 242
S DY F K
Sbjct: 585 HVS--DYTRDFLK 595
>ref|NP_035192.1| (NM_011062) 3-phosphoinositide dependent protein kinase-1; Pkb
kinase [Mus musculus]
Length = 559
Score = 89.4 bits (220), Expect = 8e-19
Identities = 82/294 (27%), Positives = 133/294 (44%), Gaps = 32/294 (10%)
Query: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI--RLDTETEGVPSTAIREISLLKELN 59
ENF+ + +GEG++ V AR T A+K + R + VP RE ++ L+
Sbjct: 83 ENFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT-RERDVMSRLD 141
Query: 60 HPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
HP VKL + KLY + +L K++ + + Y +++ L +
Sbjct: 142 HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYI--RKIGSFDETCTRFYTAEIVSALEYL 199
Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE--VVTLWYRAPEILLG 176
H ++HRDLKP+N+L+N + I++ DFG A+ + V T Y +PE+L
Sbjct: 200 HGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTE 259
Query: 177 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 236
K + D+W+LGCI ++V F +E + IF+ + E +P
Sbjct: 260 -KSACKSSDLWALGCIIYQLVAGLPPFRAGNE----YLIFQKI-IKLEYHFP-------- 305
Query: 237 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 290
+ FPK +D + + LD R +M Y P K AHPFF+ +T
Sbjct: 306 EKFFPK--ARDLVEKLLVLDATKRLGCEEMEGYGPLK--------AHPFFETIT 349
Database: mouse_ref_prot
Posted date: Mar 6, 2002 1:29 AM
Number of letters in database: 3,838,156
Number of sequences in database: 8005
Lambda K H
0.323 0.140 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,348,643
Number of Sequences: 8005
Number of extensions: 101948
Number of successful extensions: 1030
Number of sequences better than 1.0e-02: 243
Number of HSP's better than 0.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 270
Number of HSP's gapped (non-prelim): 297
length of query: 298
length of database: 3,838,156
effective HSP length: 92
effective length of query: 206
effective length of database: 3,101,696
effective search space: 638949376
effective search space used: 638949376
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 82 (36.2 bits)
