LOCUS CDK5_DROME 294 aa linear INV 20-AUG-2001
DEFINITION CELL DIVISION PROTEIN KINASE 5 HOMOLOG.
ACCESSION P48609
PID g12644288
VERSION P48609 GI:12644288
DBSOURCE swissprot: locus CDK5_DROME, accession P48609;
class: standard.
extra accessions:Q94878,Q9V7D8,created: Feb 1, 1996.
sequence updated: Aug 20, 2001.
annotation updated: Aug 20, 2001.
xrefs: gi: gi: 710416, gi: gi: 710417, gi: gi: 1523998, gi: gi:
1523999, gi: gi: 10727525, gi: gi: 7303051
xrefs (non-sequence databases): HSSP P24941, FlyBase FBgn0013762,
InterPro IPR000719, InterPro IPR002290, InterPro IPR001245, Pfam
PF00069, PROSITE PS00107, PROSITE PS00108, PROSITE PS50011
KEYWORDS Transferase; Serine/threonine-protein kinase; ATP-binding; Cell
cycle; Cell division; Phosphorylation.
SOURCE fruit fly.
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
REFERENCE 1 (residues 1 to 294)
AUTHORS Hellmich,M.R., Kennison,J.A., Hampton,L.L. and Battey,J.F.
TITLE Cloning and characterization of the Drosophila melanogaster CDK5
homolog
JOURNAL FEBS Lett. 356 (2-3), 317-321 (1994)
MEDLINE 95104441
REMARK SEQUENCE FROM N.A.
STRAIN=OREGON-R
REFERENCE 2 (residues 1 to 294)
AUTHORS Sauer,K., Weigmann,K., Sigrist,S. and Lehner,C.F.
TITLE Novel members of the cdc2-related kinase family in Drosophila:
cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase
JOURNAL Mol. Biol. Cell 7 (11), 1759-1769 (1996)
MEDLINE 97084555
REMARK SEQUENCE FROM N.A.
REFERENCE 3 (residues 1 to 294)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.-H.C., Blazej,R.G., Champe,M.,
Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G.,
Nelson,C.R., Miklos,G.L.G., Abril,J.F., Agbayani,A., An,H.-J.,
Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A.,
Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y.,
Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D.,
Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C.,
Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I.,
Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de
Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M.,
Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C.,
Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S.,
Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.-H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D.C., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.-Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., Woodage,T.,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.-F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
MEDLINE 20196006
REMARK SEQUENCE FROM N.A.
STRAIN=BERKELEY
COMMENT On Feb 1, 2001 this sequence version replaced gi:1345716.
-------------------------------------------------------------------
This SWISS-PROT entry is copyright. It is produced through a
collaboration between the Swiss Institute of Bioinformatics and
the EMBL outstation - the European Bioinformatics Institute.
The original entry is available from http://www.expasy.ch/sprot
and http://www.ebi.ac.uk/sprot
------------------------------------------------------------------.
[FUNCTION] PROBABLY INVOLVED IN THE CONTROL OF THE CELL CYCLE.
INTERACTS WITH D1 AND D3-TYPE G1 CYCLINS. POSSIBLE REGULATOR OF
NEURONAL DIFFERENTIATION AND/OR DEVELOPMENT.
[TISSUE SPECIFICITY] ABUNDANTLY EXPRESSED IN ALL ADULT TISSUES.
LOWER LEVELS FOUND IN LARVAE AND EARLY EMBRYOS. BARELY DETECTABLE
IN LATE EMBRYOS.
[SIMILARITY] BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES.
CDC2/CDKX SUBFAMILY.
FEATURES Location/Qualifiers
source 1..294
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
1..294
Protein 1..294
/product="CELL DIVISION PROTEIN KINASE 5 HOMOLOG"
/EC_number="2.7.1.-"
Region 4..286
/region_name="Domain"
/note="PROTEIN KINASE."
Site 10..18
/site_type="np-binding"
/note="ATP (BY SIMILARITY)."
Site 14
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
Site 15
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
Region 25
/region_name="Conflict"
/note="D -> A (IN REF. 1)."
Site 33
/site_type="binding"
/note="ATP (BY SIMILARITY)."
Site 126
/site_type="active"
/note="BY SIMILARITY."
Site 159
/site_type="phosphorylation"
/note="(BY SIMILARITY)."
Region 166
/region_name="Conflict"
/note="W -> L (IN REF. 1)."
ORIGIN
1 mqkydkmeki gegtygtvfk grnrdtmeiv alkrvrlded degvpssalr eicllkelkh
61 knivrlidvl hsdkkltlvf ehcdqdlkky fdslngeidm avcrsfmlql lrglafchsh
121 nvlhrdlkpq nllinkngel kladfglara fgipvkcysa evvtlwyrpp dvlfgaklyt
181 tsidmwsagc ilaeladagr plfpgsdvld qlmkifrvlg tpnedswpgv shlsdyvalp
241 sfpaitswsq lvprlnskgr dllqkllicr pnqrisaeaa mqhpyftdss ssgh
//
Revised: October 24, 2001.
