-
LOCUS NP_476797 297 aa linear INV 10-JAN-2002
DEFINITION cdc2-P1 [Drosophila melanogaster].
ACCESSION NP_476797
PID g17136606
VERSION NP_476797.1 GI:17136606
DBSOURCE REFSEQ: accession NM_057449.1
KEYWORDS .
SOURCE fruit fly.
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
REFERENCE 1 (residues 1 to 297)
AUTHORS Lehner,C.F. and O'Farrell,P.H.
TITLE Drosophila cdc2 homologs: a functional homolog is coexpressed with
a cognate variant
JOURNAL EMBO J. 9 (11), 3573-3581 (1990)
MEDLINE 91006057
PUBMED 2120045
REFERENCE 2 (residues 1 to 297)
AUTHORS Jimenez,J., Alphey,L., Nurse,P. and Glover,D.M.
TITLE Complementation of fission yeast cdc2ts and cdc25ts mutants
identifies two cell cycle genes from Drosophila: a cdc2 homologue
and string
JOURNAL EMBO J. 9 (11), 3565-3571 (1990)
MEDLINE 91006056
PUBMED 2120044
REFERENCE 3 (sites)
AUTHORS Stern,B., Ried,G., Clegg,N.J., Grigliatti,T.A. and Lehner,C.F.
TITLE Genetic analysis of the Drosophila cdc2 homolog
JOURNAL Development 117 (1), 219-232 (1993)
MEDLINE 94038657
REFERENCE 4 (sites)
AUTHORS Clegg,N.J., Whitehead,I.P., Williams,J.A., Spiegelman,G.B. and
Grigliatti,T.A.
TITLE A developmental and molecular analysis of Cdc2 mutations in
Drosophila melanogaster
JOURNAL Genome 36 (4), 676-685 (1993)
MEDLINE 94010270
REFERENCE 5 (sites)
AUTHORS Sigrist,S., Ried,G. and Lehner,C.F.
TITLE Dmcdc2 kinase is required for both meiotic divisions during
Drosophila spermatogenesis and is activated by the Twine/cdc25
phosphatase
JOURNAL Mech. Dev. 53 (2), 247-260 (1995)
MEDLINE 96122901
REFERENCE 6 (residues 1 to 297)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
MEDLINE 20196006
PUBMED 10731132
COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. The
reference sequence was derived from AC007451.1.
FEATURES Location/Qualifiers
source 1..297
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
/chromosome="2"
/map="31D11-31E1"
Protein 1..297
/product="cdc2-P1"
/EC_number="2.7.1.-"
/EC_number="2.7.1.37"
Region 4..287
/region_name="Protein kinase domain"
/db_xref="CDD:pfam00069"
/note="pkinase"
Region 4..287
/region_name="Serine/Threonine protein kinases, catalytic
domain"
/db_xref="CDD:smart00220"
/note="S_TKc"
Region 5..200
/region_name="Tyrosine kinase, catalytic domain"
/db_xref="CDD:smart00219"
/note="TyrKc"
CDS 1..297
/gene="cdc2"
/label=cdc2-P1|CDS
/db_xref="FLYBASE:FBgn0004106;"
/db_xref="LocusID:34411"
/coded_by="NM_057449.1:1..894"
ORIGIN
1 medfekieki gegtygvvyk grnrltgqiv amkkirlesd degvpstair eisllkelkh
61 enivcledvl meenriylif eflsmdlkky mdslpvdkhm eselvrsyly qitsailfch
121 rrrvlhrdlk pqnllidksg likvadfglg rsfgipvriy theivtlwyr apevllgspr
181 yscpvdiwsi gcifaematr kplfqgdsei dqlfrmfril ktptediwpg vtslpdyknt
241 fpcwstnqlt nqlknldang idliqkmliy dpvhrisakd ilehpyfngf qsglvrn
//
Revised: October 24, 2001.
