Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
RID: 1015718634-14079-18617
Query= CDK5_XENLA
(292 letters)
Database: Completed Saccharomyces cerevisiae;
Completed Caenorhabditis elegans;
26,512 sequences; 11,834,680 total letters
If you have any problems or questions with the results of this search
please refer to the BLAST FAQs
Taxonomy reports
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_499783.1| (NM_067382) serine/threonine kinase (CDC2/... 466 e-132
ref|NP_015294.1| (NC_001148) involved in phosphate and glyc... 327 4e-90
ref|NP_009718.1| (NC_001134) Catalytic subunit of the main ... 325 2e-89
ref|NP_501373.1| (NM_068972) C07G1.3b.p [Caenorhabditis ele... 305 3e-83
ref|NP_501372.1| (NM_068971) ser/thr protein kinase [Caenor... 305 3e-83
ref|NP_499153.1| (NM_066752) serine/threonine kinase (CDC2/... 303 8e-83
ref|NP_490783.1| (NM_058382) protein kinase [Caenorhabditis... 280 7e-76
ref|NP_491157.1| (NM_058756) protein kinase [Caenorhabditis... 275 3e-74
ref|NP_497873.1| (NM_065472) serine/threonine kinase (CDC2/... 227 7e-60
ref|NP_495617.1| (NM_063216) CDC2 [Caenorhabditis elegans] 225 2e-59
ref|NP_509746.1| (NM_077345) serine/threonine kinase (CDC2/... 212 2e-55
ref|NP_010175.1| (NC_001136) serine-threonine kinase, subun... 208 3e-54
ref|NP_505823.1| (NM_073422) Eukaryotic protein kinase doma... 204 4e-53
ref|NP_012783.1| (NC_001143) putative kinase subunit of the... 199 1e-51
ref|NP_490952.1| (NM_058551) Y39G10AL.3.p [Caenorhabditis e... 190 9e-49
ref|NP_009537.1| (NC_001134) Required for the arrest of cel... 186 1e-47
ref|NP_015487.1| (NC_001148) CDC28/cdc2 related protein kin... 186 2e-47
ref|NP_492493.1| (NM_060092) serine/threonine kinase (CDC2/... 182 1e-46
ref|NP_510256.1| (NM_077855) serine/threonine kinase (CDC2/... 181 6e-46
ref|NP_510257.1| (NM_077856) serine/threonine kinase (CDC2/... 179 2e-45
ref|NP_492357.1| (NM_059956) serine/threonine kinase [Caeno... 174 4e-44
ref|NP_494946.1| (NM_062545) Ser/Thr protein kinase [Caenor... 174 7e-44
ref|NP_011895.1| (NC_001140) Suppressor of lyt2; Slt2p [Sac... 173 1e-43
ref|NP_497846.1| (NM_065445) serine/threonine kinase (CDC2/... 172 3e-43
ref|NP_497847.1| (NM_065446) serine/threonine kinase (CDC2/... 172 3e-43
ref|NP_013214.1| (NC_001144) osmoregulation; Hog1p [Sacchar... 171 5e-43
ref|NP_492907.1| (NM_060506) serine/threonine kinase (CDC2/... 171 6e-43
ref|NP_492906.1| (NM_060505) serine/threonine kinase (CDC2/... 171 6e-43
ref|NP_011554.1| (NC_001139) Recovery from alpha factor arr... 169 1e-42
ref|NP_015283.1| (NC_001148) Component of RNA polymerase II... 167 7e-42
ref|NP_498320.1| (NM_065919) C05D10.2.p [Caenorhabditis ele... 167 8e-42
ref|NP_493243.1| (NM_060842) Eukaryotic protein kinase doma... 165 3e-41
ref|NP_494948.1| (NM_062547) Ser/Thr protein kinase [Caenor... 163 9e-41
ref|NP_499829.1| (NM_067428) serine/threonine kinase (CDC2/... 160 8e-40
ref|NP_499831.1| (NM_067430) W06F12.1c.p [Caenorhabditis el... 160 8e-40
ref|NP_499830.1| (NM_067429) W06F12.1b.p [Caenorhabditis el... 160 8e-40
ref|NP_510429.1| (NM_078028) glycogen synthase kinase (CDC2... 159 2e-39
ref|NP_501073.1| (NM_068672) MAP kinase [Caenorhabditis ele... 159 2e-39
ref|NP_502232.1| (NM_069831) serine/threonine kinase (2 dom... 155 2e-38
ref|NP_499922.1| (NM_067521) protein kinase [Caenorhabditis... 150 8e-37
ref|NP_501363.1| (NM_068962) protein kinase [Caenorhabditis... 150 8e-37
ref|NP_013859.1| (NC_001145) Required for Ime1p phosphoryla... 148 3e-36
ref|NP_501365.1| (NM_068964) ser/thr kinases [Caenorhabditi... 148 4e-36
ref|NP_015379.1| (NC_001148) involved in sporulation; Smk1p... 146 1e-35
ref|NP_012761.1| (NC_001143) Hypothetical ORF; Ykl161cp [Sa... 144 6e-35
ref|NP_501364.1| (NM_068963) protein kinase [Caenorhabditis... 142 3e-34
ref|NP_510009.1| (NM_077608) serine/threonine kinase (CDC2/... 142 3e-34
ref|NP_500384.1| (NM_067983) protein kinase [Caenorhabditis... 140 7e-34
ref|NP_492811.1| (NM_060410) casein kinase [Caenorhabditis ... 128 3e-30
ref|NP_010204.1| (NC_001136) putative protein kinase with s... 127 7e-30
ref|NP_012229.1| (NC_001141) alpha subunit of casein kinase... 124 8e-29
ref|NP_492689.1| (NM_060288) Helix-loop-helix DNA-binding d... 119 2e-27
ref|NP_492367.1| (NM_059966) serine/threonine kinase [Caeno... 117 6e-27
ref|NP_012440.1| (NC_001142) bypass requirement for protein... 117 6e-27
ref|NP_496356.1| (NM_063955) serine/threonine kinase [Caeno... 115 2e-26
ref|NP_490967.1| (NM_058566) Y39G10AR.4.p [Caenorhabditis e... 115 4e-26
ref|NP_491474.1| (NM_059073) ser/thr-protein kinase [Caenor... 113 1e-25
ref|NP_009411.1| (NC_001133) Required for mitosis and sporu... 112 2e-25
ref|NP_492097.1| (NM_059696) serine/threonine kinase [Caeno... 111 4e-25
ref|NP_501815.1| (NM_069414) serine/threonine kinase [Caeno... 110 1e-24
ref|NP_502493.1| (NM_070092) serine/threonine kinase (2 dom... 110 1e-24
ref|NP_502492.1| (NM_070091) F49E11.1c.p [Caenorhabditis el... 110 1e-24
ref|NP_502494.1| (NM_070093) serine/threonine kinase (2 dom... 110 1e-24
ref|NP_009998.2| (NC_001135) functionally redundant with, a... 109 2e-24
ref|NP_014704.1| (NC_001147) may have a role in regulation ... 108 3e-24
ref|NP_012394.1| (NC_001142) Serine-threonine protein kinas... 108 3e-24
ref|NP_506499.1| (NM_074098) serine/threonine kinase (KIN1/... 105 2e-23
ref|NP_510080.1| (NM_077679) serine/threonine kinase [Caeno... 105 4e-23
ref|NP_491714.1| (NM_059313) protein kinase [Caenorhabditis... 105 4e-23
ref|NP_508718.1| (NM_076317) serine/threonine protein kinas... 104 7e-23
ref|NP_509010.1| (NM_076609) Serine/threonine protein kinas... 103 1e-22
ref|NP_010182.1| (NC_001136) DNA damage response; Dun1p [Sa... 102 3e-22
ref|NP_503086.1| (NM_070685) C49C3.10b.p [Caenorhabditis el... 102 3e-22
ref|NP_501185.1| (NM_068784) ser/thr protein kinase [Caenor... 101 4e-22
ref|NP_509199.1| (NM_076798) CDC2/CDC28 subfamily of ser/th... 101 4e-22
ref|NP_492259.1| (NM_059858) serine/threonine kinase (2 dom... 101 6e-22
ref|NP_012821.1| (NC_001143) Negative regulator of swe1 kin... 101 6e-22
ref|NP_492668.1| (NM_060267) serine/threonine kinase [Caeno... 100 7e-22
ref|NP_491914.1| (NM_059513) ser/thr-protein kinase [Caenor... 100 7e-22
ref|NP_010765.1| (NC_001136) Required for release from gluc... 100 7e-22
ref|NP_508742.1| (NM_076341) C24A8.4b.p [Caenorhabditis ele... 100 1e-21
ref|NP_508744.1| (NM_076343) protein kinase [Caenorhabditis... 100 1e-21
ref|NP_508743.1| (NM_076342) F14H12.4b.p [Caenorhabditis el... 100 1e-21
ref|NP_508741.1| (NM_076340) G-protein coupled receptor [Ca... 100 1e-21
ref|NP_510253.1| (NM_077852) serine/threonine kinase (KIN1/... 100 1e-21
ref|NP_014513.1| (NC_001147) Hypothetical ORF; Yol128cp [Sa... 100 2e-21
ref|NP_014092.1| (NC_001146) Disp. for mitosis, required fo... 99 2e-21
ref|NP_011970.1| (NC_001140) Kinase that interacts with Cdc... 99 2e-21
ref|NP_502274.1| (NM_069873) Fibronectin type III domain (3... 99 3e-21
ref|NP_504721.1| (NM_072320) serine/threonine kinase [Caeno... 99 3e-21
ref|NP_502273.1| (NM_069872) Fibronectin type III domain (3... 99 3e-21
ref|NP_502989.1| (NM_070588) Y43D4A.6.p [Caenorhabditis ele... 97 8e-21
ref|NP_015115.1| (NC_001148) Regulation of yeast chromosome... 97 8e-21
ref|NP_503161.1| (NM_070760) protein kinase [Caenorhabditis... 97 1e-20
ref|NP_015175.1| (NC_001148) Hypothetical ORF; Ypl150wp [Sa... 97 1e-20
ref|NP_496002.1| (NM_063601) serine/threonine kinase [Caeno... 96 2e-20
ref|NP_010795.1| (NC_001136) Growth inhibitory gene; Gin4p ... 96 2e-20
ref|NP_009584.1| (NC_001134) Hypothetical ORF; Ybr028cp [Sa... 96 2e-20
ref|NP_015172.1| (NC_001148) Required for DNA damage-induce... 96 2e-20
ref|NP_504582.1| (NM_072181) titin [Caenorhabditis elegans] 94 7e-20
ref|NP_010811.1| (NC_001136) dispensable for mitosis, invol... 94 7e-20
ref|NP_012429.1| (NC_001142) Positive regulator of meiosis,... 94 1e-19
ref|NP_501081.1| (NM_068680) protein-tyrosine kinase [Caeno... 93 2e-19
ref|NP_503162.1| (NM_070761) protein kinase [Caenorhabditis... 93 2e-19
ref|NP_510460.1| (NM_078059) serine/threonine kinase (2 dom... 93 2e-19
ref|NP_490975.1| (NM_058574) protein kinase [Caenorhabditis... 92 3e-19
ref|NP_503087.1| (NM_070686) serine/threonine kinase (2 dom... 92 3e-19
ref|NP_009907.2| (NC_001135) involved in septin organizatio... 92 3e-19
ref|NP_491682.1| (NM_059281) B0414.7b.p [Caenorhabditis ele... 92 3e-19
ref|NP_509747.1| (NM_077346) serine/threonine kinase (PAK/S... 92 3e-19
ref|NP_491683.1| (NM_059282) protein kinase [Caenorhabditis... 92 3e-19
ref|NP_509749.1| (NM_077348) ZC504.4b.p [Caenorhabditis ele... 92 3e-19
ref|NP_505119.1| (NM_072718) protein kinase [Caenorhabditis... 92 3e-19
ref|NP_509748.1| (NM_077347) ZC504.4c.p [Caenorhabditis ele... 92 3e-19
ref|NP_013714.1| (NC_001145) CDC5 is dispensable for premei... 92 3e-19
ref|NP_493390.1| (NM_060989) Phorbol esters/diacylglycerol ... 92 5e-19
ref|NP_015184.1| (NC_001148) Hypothetical ORF; Ypl141cp [Sa... 92 5e-19
ref|NP_492826.1| (NM_060425) protein kinase [Caenorhabditis... 91 6e-19
ref|NP_494925.1| (NM_062524) Protein kinase [Caenorhabditis... 91 6e-19
ref|NP_500846.1| (NM_068445) tyrosine-protein kinase [Caeno... 91 6e-19
ref|NP_507239.1| (NM_074838) Phorbol esters/diacylglycerol ... 91 6e-19
ref|NP_014874.1| (NC_001147) Mitogen-activated kinase-kinas... 91 6e-19
ref|NP_011055.1| (NC_001137) high copy suppressor of temper... 91 6e-19
ref|NP_501896.1| (NM_069495) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_505309.1| (NM_072908) serine/threonine kinase [Caeno... 91 8e-19
ref|NP_501901.1| (NM_069500) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_501900.1| (NM_069499) calcium/calmodulin dependent p... 91 8e-19
ref|NP_501904.1| (NM_069503) calcium/calmodulin dependent p... 91 8e-19
ref|NP_501905.1| (NM_069504) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_501902.1| (NM_069501) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_505810.1| (NM_073409) P21-Rho-binding domain ; Eukar... 91 8e-19
ref|NP_505310.1| (NM_072909) T19A5.2b.p [Caenorhabditis ele... 91 8e-19
ref|NP_501898.1| (NM_069497) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_501897.1| (NM_069496) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_501903.1| (NM_069502) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_505809.1| (NM_073408) serine/threonine kinase (PAK/S... 91 8e-19
ref|NP_501899.1| (NM_069498) Ca2+/calmodulin-dependent prot... 91 8e-19
ref|NP_013466.1| (NC_001144) involved in the mating signall... 91 1e-18
ref|NP_509198.1| (NM_076797) CDC2/CDC28 subfamily of ser/th... 90 1e-18
ref|NP_490820.1| (NM_058419) protein kinase [Caenorhabditis... 90 1e-18
ref|NP_503159.1| (NM_070758) protein kinase [Caenorhabditis... 90 2e-18
ref|NP_015185.1| (NC_001148) Member of MAP kinase pathway i... 90 2e-18
ref|NP_507869.1| (NM_075468) serine/threonine protein kinas... 89 2e-18
ref|NP_509778.1| (NM_077377) Src homology domain 2, Src hom... 89 3e-18
ref|NP_510710.1| (NM_078309) T01C8.1b.p [Caenorhabditis ele... 89 3e-18
ref|NP_510711.1| (NM_078310) ser/thr-protein kinase [Caenor... 89 3e-18
ref|NP_509777.1| (NM_077376) M79.1b.p [Caenorhabditis elegans] 89 3e-18
ref|NP_509779.1| (NM_077378) M79.1c.p [Caenorhabditis elegans] 89 3e-18
ref|NP_014428.1| (NC_001146) Suppressor of Sensor Kinase (S... 89 3e-18
ref|NP_011336.1| (NC_001139) Hypothetical ORF; Tos3p [Sacch... 89 3e-18
ref|NP_508493.1| (NM_076092) serine/threonine-protein kinas... 88 5e-18
ref|NP_504040.1| (NM_071639) Y39H10A.7.p [Caenorhabditis el... 88 5e-18
ref|NP_010256.1| (NC_001136) Required for spindle pole body... 88 5e-18
ref|NP_011856.1| (NC_001140) Involved in pheromone response... 88 5e-18
ref|NP_010122.1| (NC_001136) Serine/threonine/tyrosine prot... 88 7e-18
ref|NP_492320.1| (NM_059919) Protein kinase C terminal doma... 87 9e-18
ref|NP_492319.1| (NM_059918) Protein kinase C terminal doma... 87 9e-18
ref|NP_012075.1| (NC_001140) protein kinase involved in gro... 87 1e-17
ref|NP_496769.1| (NM_064368) Eukaryotic protein kinase doma... 87 1e-17
ref|NP_499937.1| (NM_067536) protein kinase [Caenorhabditis... 87 1e-17
ref|NP_500139.1| (NM_067738) ser/thr protein kinase [Caenor... 87 1e-17
ref|NP_010754.1| (NC_001136) Hypothetical ORF; Ydr466wp [Sa... 87 1e-17
ref|NP_498214.1| (NM_065813) C05H8.1.p [Caenorhabditis eleg... 86 2e-17
ref|NP_498933.1| (NM_066532) Protein kinase [Caenorhabditis... 86 3e-17
ref|NP_509104.1| (NM_076703) protein-tyrosine kinase [Caeno... 85 4e-17
ref|NP_509105.1| (NM_076704) T14E8.1b.p [Caenorhabditis ele... 85 4e-17
ref|NP_496201.1| (NM_063800) tyrosine-protein kinase (FES/F... 85 4e-17
ref|NP_508095.1| (NM_075694) homeobox; centromeric protein ... 85 6e-17
ref|NP_492594.1| (NM_060193) Src homology domain 2, tyrosin... 85 6e-17
ref|NP_508833.1| (NM_076432) Serine/Threonine protein kinas... 85 6e-17
ref|NP_014876.1| (NC_001147) protein kinase; Kin4p [Sacchar... 85 6e-17
ref|NP_499953.1| (NM_067552) protein kinase [Caenorhabditis... 84 7e-17
ref|NP_498327.1| (NM_065926) T17E9.1.p [Caenorhabditis eleg... 84 7e-17
ref|NP_014216.1| (NC_001146) protein kinase homolog; Npr1p ... 84 7e-17
ref|NP_012796.1| (NC_001143) 76.5 kDa Serine/threonine prot... 84 7e-17
ref|NP_509576.1| (NM_077175) Protein kinase C [Caenorhabdit... 84 9e-17
ref|NP_493502.1| (NM_061101) Src homology domain 2, Src hom... 83 2e-16
ref|NP_498770.1| (NM_066369) Protein kinase [Caenorhabditis... 83 2e-16
ref|NP_496450.1| (NM_064049) serine/threonine kinase [Caeno... 83 2e-16
ref|NP_492629.1| (NM_060228) serine/threonine kinase [Caeno... 83 2e-16
ref|NP_010067.1| (NC_001136) Prr2p [Saccharomyces cerevisiae] 83 2e-16
ref|NP_491036.1| (NM_058635) Y71F9B.7.p [Caenorhabditis ele... 82 4e-16
ref|NP_498178.1| (NM_065777) D1044.3.p [Caenorhabditis eleg... 81 8e-16
ref|NP_510647.1| (NM_078246) Protein kinase C terminal doma... 81 8e-16
ref|NP_509682.1| (NM_077281) serine/threonine kinase [Caeno... 81 8e-16
ref|NP_501196.1| (NM_068795) protein kinase [Caenorhabditis... 80 1e-15
ref|NP_509322.1| (NM_076921) SER/THR-protein kinase [Caenor... 80 1e-15
ref|NP_510290.1| (NM_077889) serine/threonine kinase [Caeno... 80 1e-15
ref|NP_506014.1| (NM_073613) Phorbol esters / diacylglycero... 80 1e-15
ref|NP_498589.1| (NM_066188) Tyrosine kinase [Caenorhabditi... 80 1e-15
ref|NP_116669.1| (NC_001138) Calmodulin-dependent protein k... 80 1e-15
ref|NP_013822.1| (NC_001145) protein kinase; Ypk2p [Sacchar... 80 1e-15
ref|NP_502160.1| (NM_069759) tyrosine-protein kinase [Caeno... 80 2e-15
ref|NP_491175.1| (NM_058774) tyrosine kinase [Caenorhabditi... 80 2e-15
ref|NP_501793.1| (NM_069392) Src homology domain 2, tyrosin... 80 2e-15
ref|NP_491516.1| (NM_059115) protein kinase [Caenorhabditis... 80 2e-15
ref|NP_490680.1| (NM_058279) protein-tyrosine kinase [Caeno... 79 2e-15
ref|NP_499145.1| (NM_066744) serine/threonine kinase [Caeno... 79 3e-15
ref|NP_501758.1| (NM_069357) tyrosine-protein kinase (FES/F... 79 4e-15
ref|NP_495011.1| (NM_062610) Protein kinase C [Caenorhabdit... 79 4e-15
ref|NP_491705.1| (NM_059304) ser/thr-protein kinase [Caenor... 78 5e-15
ref|NP_014910.1| (NC_001147) Hypothetical ORF; Yor267cp [Sa... 78 5e-15
ref|NP_508060.1| (NM_075659) Forkhead-associated (FHA) doma... 78 7e-15
ref|NP_499294.1| (NM_066893) cAMP-dependant protein kinase ... 78 7e-15
ref|NP_009410.1| (NC_001133) protein kinase; Kin3p [Sacchar... 78 7e-15
ref|NP_011566.1| (NC_001139) Hypothetical ORF; Ygr052wp [Sa... 78 7e-15
ref|NP_501994.1| (NM_069593) Src homology domain 2, protein... 77 9e-15
ref|NP_501761.1| (NM_069360) tyrosine-protein kinase [Caeno... 77 9e-15
ref|NP_492786.1| (NM_060385) protein kinase [Caenorhabditis... 77 9e-15
ref|NP_492008.1| (NM_059607) serine/threonine kinase [Caeno... 77 1e-14
ref|NP_495103.1| (NM_062702) F59E12.2.p [Caenorhabditis ele... 77 1e-14
ref|NP_507854.1| (NM_075453) Y60A3A.12.p [Caenorhabditis el... 77 2e-14
ref|NP_501603.1| (NM_069202) serine/threonine kinase [Caeno... 77 2e-14
ref|NP_014541.1| (NC_001147) Pkb-activating Kinase Homologu... 77 2e-14
ref|NP_013197.1| (NC_001144) Serine/threonine protein kinas... 77 2e-14
ref|NP_011335.1| (NC_001139) Required for autophagy; Apg1p ... 77 2e-14
ref|NP_502595.1| (NM_070194) serine/threonine kinase [Caeno... 76 2e-14
ref|NP_507533.1| (NM_075132) serine-threonine protein kinas... 76 2e-14
ref|NP_495701.1| (NM_063300) serine/threonine kinase [Caeno... 76 2e-14
ref|NP_014528.1| (NC_001147) Serine/threonine protein kinas... 76 2e-14
ref|NP_012755.1| (NC_001143) Involved in nutrient control o... 76 2e-14
ref|NP_491087.1| (NM_058686) protein kinase [Caenorhabditis... 76 3e-14
ref|NP_491440.1| (NM_059039) Rho-associated kinase [Caenorh... 76 3e-14
ref|NP_496095.1| (NM_063694) serine/threonine kinase [Caeno... 76 3e-14
ref|NP_497235.1| (NM_064834) G-protein coupled receptor [Ca... 76 3e-14
ref|NP_502037.1| (NM_069636) tyrosine-protein kinase [Caeno... 75 3e-14
ref|NP_009934.1| (NC_001135) Protein with similarity to Npr... 75 3e-14
ref|NP_501818.1| (NM_069417) Src homology domain 2, tyrosin... 75 4e-14
ref|NP_508243.1| (NM_075842) protein kinase [Caenorhabditis... 75 4e-14
ref|NP_510082.1| (NM_077681) MAGUK protein, calcium/calmodu... 75 4e-14
ref|NP_009445.1| (NC_001134) Protein Kinase C; Pkc1p [Sacch... 75 4e-14
ref|NP_009833.1| (NC_001134) checkpoint kinase 1; homolog o... 75 4e-14
ref|NP_502418.1| (NM_070017) Src homology domain 3, tyrosin... 75 6e-14
ref|NP_508242.1| (NM_075841) H42K12.1b.p [Caenorhabditis el... 75 6e-14
ref|NP_014101.1| (NC_001146) Involved in localizing cell gr... 75 6e-14
ref|NP_501309.1| (NM_068908) tyosine-protein kinase [Caenor... 74 7e-14
ref|NP_501458.1| (NM_069057) cAMP-dependant protein kinase ... 74 1e-13
ref|NP_498153.1| (NM_065752) W03A5.1.p [Caenorhabditis eleg... 74 1e-13
ref|NP_116624.1| (NC_001138) binds and phosphorylates Cdc28... 74 1e-13
ref|NP_492204.1| (NM_059803) Protein kinase C terminal doma... 74 1e-13
ref|NP_508671.1| (NM_076270) F47F2.1b.p [Caenorhabditis ele... 74 1e-13
ref|NP_508573.1| (NM_076172) F11D5.3b.p [Caenorhabditis ele... 74 1e-13
ref|NP_508572.1| (NM_076171) tyrosine kinase [Caenorhabditi... 74 1e-13
ref|NP_503160.1| (NM_070759) DC2.7b.p [Caenorhabditis elegans] 73 2e-13
ref|NP_505637.1| (NM_073236) PH (pleckstrin homology) doma... 73 2e-13
ref|NP_012371.1| (NC_001142) putative catalytic subunit of ... 73 2e-13
ref|NP_509742.1| (NM_077341) Protein kinase C terminal doma... 72 3e-13
ref|NP_496679.1| (NM_064278) serine/threonine kinase (KIN1/... 72 3e-13
ref|NP_502587.1| (NM_070186) Eukaryotic protein kinase doma... 72 4e-13
ref|NP_510783.1| (NM_078382) protein tyrosine kinase [Caeno... 72 4e-13
ref|NP_508971.1| (NM_076570) serine/threonine-protein kinas... 72 4e-13
ref|NP_510784.1| (NM_078383) B0302.1b.p [Caenorhabditis ele... 72 4e-13
ref|NP_014445.1| (NC_001146) Hypothetical ORF; Ynr047wp [Sa... 72 4e-13
ref|NP_509676.1| (NM_077275) G protein-coupled receptor kin... 72 5e-13
ref|NP_496009.1| (NM_063608) Src homology domain 2, tyrosin... 72 5e-13
ref|NP_502591.1| (NM_070190) Eukaryotic protein kinase doma... 72 5e-13
ref|NP_509689.1| (NM_077288) calcium/calmodulin dependent p... 72 5e-13
ref|NP_507517.1| (NM_075116) Y59A8B.23.p [Caenorhabditis el... 72 5e-13
ref|NP_503039.1| (NM_070638) Y116A8C.38.p [Caenorhabditis e... 72 5e-13
ref|NP_012407.1| (NC_001142) Involved in osmoregulation, me... 72 5e-13
ref|NP_510358.1| (NM_077957) PH (pleckstrin homology) doma... 71 6e-13
ref|NP_491913.1| (NM_059512) protein-tyrosine kinase [Caeno... 71 6e-13
ref|NP_498511.1| (NM_066110) putative protein tyrosine kina... 71 6e-13
ref|NP_510357.1| (NM_077956) PH (pleckstrin homology) doma... 71 6e-13
ref|NP_015121.1| (NC_001148) Involved in nutrient control o... 71 6e-13
ref|NP_505770.1| (NM_073369) calcium/calmodulin dependent p... 71 8e-13
ref|NP_490840.1| (NM_058439) ankyrin and protein kinase [Ca... 71 8e-13
ref|NP_499861.1| (NM_067460) protein kinase [Caenorhabditis... 71 8e-13
ref|NP_499860.1| (NM_067459) protein kinase [Caenorhabditis... 71 8e-13
ref|NP_116620.1| (NC_001138) RIM15 is glucose-repressed; RI... 71 8e-13
ref|NP_010407.1| (NC_001136) Serine/threonine protein kinas... 71 8e-13
ref|NP_491620.1| (NM_059219) protein kinase [Caenorhabditis... 70 1e-12
ref|NP_509683.1| (NM_077282) serine/threonine kinase [Caeno... 70 1e-12
ref|NP_014626.1| (NC_001147) Calmodulin-dependent protein k... 70 1e-12
ref|NP_503024.1| (NM_070623) Y116A8C.24.p [Caenorhabditis e... 70 1e-12
ref|NP_502563.1| (NM_070162) Eukaryotic protein kinase doma... 70 1e-12
ref|NP_010259.1| (NC_001136) Hypothetical ORF; Ydl025cp [Sa... 70 1e-12
ref|NP_500142.1| (NM_067741) cyclic-GMP-dependent protein k... 70 2e-12
ref|NP_496058.1| (NM_063657) serine/threonine kinase [Caeno... 70 2e-12
ref|NP_500141.1| (NM_067740) cyclic-GMP-dependent protein k... 70 2e-12
ref|NP_510508.1| (NM_078107) protein kinase [Caenorhabditis... 70 2e-12
ref|NP_499447.1| (NM_067046) ribosomal protein S6 kinase [C... 69 2e-12
ref|NP_500644.1| (NM_068243) protein kinase [Caenorhabditis... 69 3e-12
ref|NP_502161.1| (NM_069760) serine/threonine kinase [Caeno... 69 4e-12
ref|NP_494745.1| (NM_062344) protein kinase [Caenorhabditis... 69 4e-12
ref|NP_010778.1| (NC_001136) Pkb-activating Kinase Homologu... 69 4e-12
ref|NP_010533.1| (NC_001136) Hypothetical ORF; Ydr247wp [Sa... 68 5e-12
ref|NP_491966.1| (NM_059565) tyrosine-protein kinase [Caeno... 68 7e-12
ref|NP_500006.1| (NM_067605) C44C8.6b.p [Caenorhabditis ele... 67 9e-12
ref|NP_500005.1| (NM_067604) protein kinase [Caenorhabditis... 67 9e-12
ref|NP_010015.2| (NC_001135) Putative serine/threonine prot... 67 9e-12
ref|NP_012593.1| (NC_001142) Putative serine/threonine prot... 67 9e-12
ref|NP_502040.1| (NM_069639) Eukaryotic protein kinase doma... 67 1e-11
ref|NP_493605.1| (NM_061204) Protein kinase C terminal doma... 67 2e-11
ref|NP_493606.1| (NM_061205) cAMP-dependant protein kinase ... 67 2e-11
ref|NP_508627.1| (NM_076226) protein kinase [Caenorhabditis... 67 2e-11
ref|NP_015299.1| (NC_001148) multicopy suppressor of snf3 a... 67 2e-11
ref|NP_491949.1| (NM_059548) protein kinase [Caenorhabditis... 66 2e-11
ref|NP_011946.1| (NC_001140) Involved in myo-inositol biosy... 66 2e-11
ref|NP_497650.1| (NM_065249) Y55D5A.5.p [Caenorhabditis ele... 66 3e-11
ref|NP_492004.1| (NM_059603) Src homology domain 2, tyrosin... 66 3e-11
ref|NP_009385.1| (NC_001133) contains serine/threonine prot... 66 3e-11
ref|NP_490866.1| (NM_058465) Y92H12A.1.p [Caenorhabditis el... 65 3e-11
ref|NP_492970.1| (NM_060569) tyrosine-protein kinase (KIN15... 65 3e-11
ref|NP_501934.1| (NM_069533) tyrosine-protein kinase (FES/F... 65 3e-11
ref|NP_508114.1| (NM_075713) protein kinase [Caenorhabditis... 65 3e-11
ref|NP_492827.1| (NM_060426) protein kinase [Caenorhabditis... 65 5e-11
ref|NP_504459.1| (NM_072058) protein kinase [Caenorhabditis... 65 6e-11
ref|NP_497551.1| (NM_065150) protein kinase [Caenorhabditis... 65 6e-11
ref|NP_504458.1| (NM_072057) protein kinase [Caenorhabditis... 65 6e-11
ref|NP_011606.1| (NC_001139) kinase required for late nucle... 65 6e-11
ref|NP_501993.1| (NM_069592) Src homology domain 2, protein... 64 8e-11
ref|NP_492969.1| (NM_060568) W04G5.10.p [Caenorhabditis ele... 64 8e-11
ref|NP_508853.1| (NM_076452) map kinase kinase; 3beta-hsd [... 64 8e-11
ref|NP_499631.1| (NM_067230) Y111B2A.1.p [Caenorhabditis el... 64 1e-10
ref|NP_498490.1| (NM_066089) seven-transmembrane receptor [... 64 1e-10
ref|NP_012753.1| (NC_001143) Serine/threonine protein kinas... 64 1e-10
ref|NP_492620.1| (NM_060219) tyrosine-protein kinase [Caeno... 64 1e-10
ref|NP_492699.1| (NM_060298) Protein kinase C terminal doma... 64 1e-10
ref|NP_509263.1| (NM_076862) Map kinase kinase [Caenorhabdi... 64 1e-10
ref|NP_010569.1| (NC_001136) Derepression of GCN4 expressio... 64 1e-10
ref|NP_010267.1| (NC_001136) Required for mitotic DNA synth... 64 1e-10
ref|NP_504599.1| (NM_072198) serine/threonine-protein kinas... 63 2e-10
ref|NP_494994.1| (NM_062593) tyrosine-protein kinase [Caeno... 63 2e-10
ref|NP_495860.1| (NM_063459) ribosomal S6 kinase [Caenorhab... 63 2e-10
ref|NP_508672.1| (NM_076271) protein kinase [Caenorhabditis... 63 2e-10
ref|NP_503375.1| (NM_070974) Y50D4B.6.p [Caenorhabditis ele... 63 2e-10
ref|NP_510382.1| (NM_077981) serine/threonine kinase (CLK s... 63 2e-10
ref|NP_495962.1| (NM_063561) tyrosine-protein kinase (Epide... 62 3e-10
ref|NP_493187.1| (NM_060786) Eukaryotic protein kinase doma... 62 3e-10
ref|NP_014597.1| (NC_001147) Hypothetical ORF; Yol045wp [Sa... 62 3e-10
ref|NP_497696.1| (NM_065295) serine/threonine kinase [Caeno... 62 4e-10
ref|NP_501034.1| (NM_068633) protein kinase [Caenorhabditis... 62 4e-10
ref|NP_509843.1| (NM_077442) F58A3.2b.p [Caenorhabditis ele... 62 5e-10
ref|NP_500813.1| (NM_068412) protein kinase [Caenorhabditis... 62 5e-10
ref|NP_509842.1| (NM_077441) F58A3.2c.p [Caenorhabditis ele... 62 5e-10
ref|NP_497240.1| (NM_064839) C24A1.3.p [Caenorhabditis eleg... 62 5e-10
ref|NP_501307.1| (NM_068906) T06C10.3.p [Caenorhabditis ele... 61 7e-10
ref|NP_495981.1| (NM_063580) protein tyrosine kinase recept... 61 7e-10
ref|NP_503111.1| (NM_070710) Eukaryotic protein kinase doma... 61 7e-10
ref|NP_508913.1| (NM_076512) F35C8.3.p [Caenorhabditis eleg... 61 9e-10
ref|NP_013081.1| (NC_001144) protein kinase homolog; Kns1p ... 61 9e-10
ref|NP_015436.1| (NC_001148) kinase required for late nucle... 61 9e-10
ref|NP_493812.1| (NM_061411) protein kinase [Caenorhabditis... 60 1e-09
ref|NP_495419.1| (NM_063018) Tyrosine-protein kinase [Caeno... 59 2e-09
ref|NP_496017.1| (NM_063616) tyrosine-protein kinase (KIN15... 59 2e-09
ref|NP_499404.1| (NM_067003) serine/threonine kinase [Caeno... 59 3e-09
ref|NP_494807.1| (NM_062406) tyrosine-protein kinase recept... 59 4e-09
ref|NP_495117.1| (NM_062716) C25H3.1.p [Caenorhabditis eleg... 58 6e-09
ref|NP_011357.1| (NC_001139) Serine/threonine protein kinas... 58 6e-09
ref|NP_494971.1| (NM_062570) tyrosine-protein kinase [Caeno... 58 7e-09
ref|NP_491433.1| (NM_059032) serine/threonine protein kinas... 58 7e-09
ref|NP_498528.1| (NM_066127) C06E8.3b.p [Caenorhabditis ele... 58 7e-09
ref|NP_498527.1| (NM_066126) Protein kinase [Caenorhabditis... 58 7e-09
ref|NP_012370.1| (NC_001142) Protein kinase homolog, mutant... 57 9e-09
ref|NP_492694.1| (NM_060293) casein kinase like [Caenorhabd... 57 1e-08
ref|NP_509433.1| (NM_077032) protein-tyosine kinase [Caenor... 57 1e-08
ref|NP_013349.1| (NC_001144) Serine/threonine protein kinas... 57 2e-08
ref|NP_494995.1| (NM_062594) guanylate cyclase [Caenorhabdi... 56 2e-08
ref|NP_497929.1| (NM_065528) serine/threonine kinase [Caeno... 56 3e-08
ref|NP_497928.1| (NM_065527) serine/threonine kinase [Caeno... 56 3e-08
ref|NP_014238.1| (NC_001146) cell wall biosynthesis kinase;... 56 3e-08
ref|NP_496016.1| (NM_063615) tyrosine-protein kinase (KIN15... 55 4e-08
ref|NP_012806.1| (NC_001143) Prr1p [Saccharomyces cerevisiae] 55 4e-08
ref|NP_504357.1| (NM_071956) K11D12.10.p [Caenorhabditis el... 55 5e-08
ref|NP_496272.1| (NM_063871) serine/threonine kinase [Caeno... 55 6e-08
ref|NP_501906.1| (NM_069505) calcium/calmodulin dependent p... 55 6e-08
ref|NP_510182.1| (NM_077781) tyrosine-protein kinase [Caeno... 54 8e-08
ref|NP_508638.1| (NM_076237) serine/threonine protein kinas... 54 8e-08
ref|NP_497818.1| (NM_065417) casein Kinase I [Caenorhabditi... 54 1e-07
ref|NP_490976.1| (NM_058575) protein kinase [Caenorhabditis... 54 1e-07
ref|NP_496130.1| (NM_063729) tyrosine-protein kinase (KIN15... 54 1e-07
ref|NP_014996.1| (NC_001147) Disp. for chr. pairing & chr. ... 54 1e-07
ref|NP_501826.1| (NM_069425) tyrosine-protein kinase [Caeno... 53 2e-07
ref|NP_505650.1| (NM_073249) guanylate cyclase (2 domains)... 53 2e-07
ref|NP_502028.1| (NM_069627) serine/threonine kinase [Caeno... 53 2e-07
ref|NP_502888.1| (NM_070487) Y105C5A.24.p [Caenorhabditis e... 53 2e-07
ref|NP_012723.1| (NC_001143) Putative serine/threonine prot... 53 2e-07
ref|NP_498522.1| (NM_066121) F31E3.2b.p [Caenorhabditis ele... 52 3e-07
ref|NP_494806.1| (NM_062405) M03A1.1b.p [Caenorhabditis ele... 52 3e-07
ref|NP_498523.1| (NM_066122) Protein kinase [Caenorhabditis... 52 3e-07
ref|NP_011950.1| (NC_001140) Serine/threonine kinase simila... 52 3e-07
ref|NP_498211.1| (NM_065810) C05D2.1a.p [Caenorhabditis ele... 52 4e-07
ref|NP_496025.1| (NM_063624) tyrosine-protein kinase (KIN15... 52 4e-07
ref|NP_506771.1| (NM_074370) tyrosine-protein kinase (KIN15... 52 4e-07
ref|NP_510533.1| (NM_078132) casein Kinase I [Caenorhabditi... 52 4e-07
ref|NP_508075.1| (NM_075674) Y73B3A.16.p [Caenorhabditis el... 52 5e-07
ref|NP_493047.1| (NM_060646) F58D5.4a.p [Caenorhabditis ele... 52 5e-07
ref|NP_493048.1| (NM_060647) F58D5.4b.p [Caenorhabditis ele... 52 5e-07
ref|NP_012348.1| (NC_001142) Protein kinase that inhibits G... 52 5e-07
ref|NP_491292.1| (NM_058891) protein kinase [Caenorhabditis... 51 7e-07
ref|NP_496124.1| (NM_063723) tyrosine-protein kinase (2 dom... 51 7e-07
ref|NP_509396.1| (NM_076995) F13B9.5.p [Caenorhabditis eleg... 51 9e-07
ref|NP_491379.1| (NM_058978) natriuretic peptides receptor ... 51 9e-07
ref|NP_491380.1| (NM_058979) guanylyl cyclase [Caenorhabdit... 51 9e-07
ref|NP_504827.1| (NM_072426) tyrosine protein kinase [Caeno... 50 1e-06
ref|NP_012003.1| (NC_001140) membrane-bound casein kinase I... 50 1e-06
ref|NP_496781.1| (NM_064380) Eukaryotic protein kinase doma... 50 2e-06
ref|NP_497181.1| (NM_064780) Y50D7A.3.p [Caenorhabditis ele... 50 2e-06
ref|NP_499962.1| (NM_067561) protein kinase [Caenorhabditis... 50 2e-06
ref|NP_014019.1| (NC_001145) Hypothetical ORF; Ymr291wp [Sa... 50 2e-06
ref|NP_498768.1| (NM_066367) K06H7.8.p [Caenorhabditis eleg... 49 3e-06
ref|NP_499080.1| (NM_066679) serine/threonine kinase (2 dom... 49 4e-06
ref|NP_499082.1| (NM_066681) Eukaryotic protein kinase doma... 49 4e-06
ref|NP_498912.1| (NM_066511) Tyrosine kinase [Caenorhabditi... 49 4e-06
ref|NP_499081.1| (NM_066680) Eukaryotic protein kinase doma... 49 4e-06
ref|NP_014245.1| (NC_001146) membrane-bound casein kinase I... 49 4e-06
ref|NP_496123.1| (NM_063722) tyrosine-protein kinase (KIN15... 48 6e-06
ref|NP_497158.1| (NM_064757) protein kinase [Caenorhabditis... 48 8e-06
ref|NP_510730.1| (NM_078329) serine/threonine-protein kinas... 48 8e-06
ref|NP_014378.1| (NC_001146) actin regulating kinase; Ark1p... 48 8e-06
ref|NP_506224.1| (NM_073823) casein Kinase I [Caenorhabditi... 47 1e-05
ref|NP_497900.1| (NM_065499) serine/threonine kinase [Caeno... 47 1e-05
ref|NP_502112.1| (NM_069711) serine/threonine kinase [Caeno... 47 1e-05
ref|NP_509374.1| (NM_076973) ser/thr protein kinase [Caenor... 47 1e-05
ref|NP_502093.1| (NM_069692) serine/threonine kinase [Caeno... 47 1e-05
ref|NP_509688.1| (NM_077287) serine/threonine kinase [Caeno... 47 2e-05
ref|NP_492838.1| (NM_060437) protein kinase [Caenorhabditis... 46 2e-05
ref|NP_508916.1| (NM_076515) F35C8.1.p [Caenorhabditis eleg... 46 2e-05
ref|NP_505159.1| (NM_072758) serine /threonine-protein kina... 46 2e-05
ref|NP_509512.1| (NM_077111) tyrosine-protein kinase [Caeno... 46 3e-05
ref|NP_009655.1| (NC_001134) myristoylated protein kinase i... 46 3e-05
ref|NP_495715.1| (NM_063314) serine/threonine kinase [Caeno... 45 4e-05
ref|NP_499835.1| (NM_067434) serine/threonine kinase [Caeno... 45 4e-05
ref|NP_009615.1| (NC_001134) Ark-family kinase-like protein... 45 4e-05
ref|NP_500739.1| (NM_068338) protein kinase [Caenorhabditis... 45 5e-05
ref|NP_495333.1| (NM_062932) Casein kinase [Caenorhabditis ... 45 6e-05
ref|NP_496542.1| (NM_064141) serine/threonine kinase [Caeno... 45 6e-05
ref|NP_499311.1| (NM_066910) serine/threonine kinase [Caeno... 44 8e-05
ref|NP_506600.1| (NM_074199) serine/threonine kinase [Caeno... 44 8e-05
ref|NP_495347.1| (NM_062946) F54H5.2.p [Caenorhabditis eleg... 44 8e-05
ref|NP_013943.1| (NC_001145) SRPK1-like Kinase in Yeast (SR... 44 8e-05
ref|NP_501832.1| (NM_069431) serine/threonine kinase [Caeno... 44 1e-04
ref|NP_501824.1| (NM_069423) serine/threonine kinase [Caeno... 44 1e-04
ref|NP_496691.1| (NM_064290) Y38E10A.8.p [Caenorhabditis el... 44 1e-04
ref|NP_495271.1| (NM_062870) Activin receptor [Caenorhabdit... 44 1e-04
ref|NP_499308.1| (NM_066907) serine/threonine kinase [Caeno... 44 1e-04
ref|NP_509912.1| (NM_077511) eukaryotic translation initiat... 44 1e-04
ref|NP_508456.1| (NM_076055) protein kinase [Caenorhabditis... 44 1e-04
ref|NP_496946.1| (NM_064545) protein kinase [Caenorhabditis... 44 1e-04
ref|NP_496022.1| (NM_063621) tyrosine-protein kinase (KIN15... 44 1e-04
ref|NP_501324.1| (NM_068923) receptor-type guanylyl cyclase... 43 2e-04
ref|NP_506259.1| (NM_073858) serine/threonine kinase [Caeno... 43 2e-04
ref|NP_501483.1| (NM_069082) serine/threonine-protein kinas... 43 2e-04
ref|NP_491162.1| (NM_058761) protein kinase [Caenorhabditis... 43 2e-04
ref|NP_500812.1| (NM_068411) protein kinase [Caenorhabditis... 43 2e-04
ref|NP_015120.1| (NC_001148) Similar to YCK1 and YCK2, two ... 43 2e-04
ref|NP_012876.1| (NC_001143) cell morphology; Elm1p [Saccha... 43 2e-04
ref|NP_504751.1| (NM_072350) serine/threonine-protein kinas... 43 2e-04
ref|NP_510266.1| (NM_077865) guanylate cyclase [Caenorhabdi... 43 2e-04
ref|NP_490669.1| (NM_058268) Y48G1C.2.p [Caenorhabditis ele... 43 2e-04
ref|NP_504685.1| (NM_072284) protein kinase [Caenorhabditis... 43 2e-04
ref|NP_503345.1| (NM_070944) K09C6.1.p [Caenorhabditis eleg... 42 4e-04
ref|NP_497820.1| (NM_065419) serine/threonine kinase [Caeno... 42 5e-04
ref|NP_510731.1| (NM_078330) serine/threonine-protein kinas... 41 7e-04
ref|NP_499571.1| (NM_067170) Y79H2A.11.p [Caenorhabditis el... 41 7e-04
ref|NP_495349.1| (NM_062948) casein kinase I [Caenorhabditi... 41 7e-04
ref|NP_491444.1| (NM_059043) protein kinase [Caenorhabditis... 41 7e-04
ref|NP_495099.1| (NM_062698) F59E12.3.p [Caenorhabditis ele... 41 0.001
ref|NP_510198.1| (NM_077797) serine/threonine kinase [Caeno... 41 0.001
ref|NP_500309.1| (NM_067908) T26C12.4.p [Caenorhabditis ele... 41 0.001
ref|NP_502428.1| (NM_070027) serine/threonine kinase [Caeno... 40 0.001
ref|NP_500816.1| (NM_068415) protein kinase [Caenorhabditis... 40 0.001
ref|NP_508684.1| (NM_076283) protein tyrosine kinase [Caeno... 40 0.002
ref|NP_498639.1| (NM_066238) protein kinase [Caenorhabditis... 40 0.002
ref|NP_509065.1| (NM_076664) protein kinase [Caenorhabditis... 40 0.002
ref|NP_496219.1| (NM_063818) guanylate cyclase [Caenorhabdi... 40 0.002
ref|NP_510377.1| (NM_077976) serine/threonine kinase [Caeno... 40 0.002
ref|NP_495017.1| (NM_062616) EEED8.9.p [Caenorhabditis eleg... 39 0.003
ref|NP_499015.1| (NM_066614) serine/threonine kinase [Caeno... 39 0.003
ref|NP_491074.1| (NM_058673) protein kinase [Caenorhabditis... 39 0.003
ref|NP_495224.1| (NM_062823) C29H12.5.p [Caenorhabditis ele... 39 0.003
ref|NP_490767.1| (NM_058366) Y65B4A.9.p [Caenorhabditis ele... 39 0.003
ref|NP_495788.1| (NM_063387) serine/threonine kinase [Caeno... 39 0.003
ref|NP_495737.1| (NM_063336) serine/threonine kinase [Caeno... 39 0.003
ref|NP_502449.1| (NM_070048) guanylate cyclase [Caenorhabdi... 39 0.003
ref|NP_508915.1| (NM_076514) F35C8.2.p [Caenorhabditis eleg... 39 0.003
ref|NP_012171.1| (NC_001141) p53 regulatory kinase; Prk1p [... 39 0.003
ref|NP_497999.1| (NM_065598) Protein kinase [Caenorhabditis... 39 0.003
ref|NP_494491.1| (NM_062090) guanylate cyclase [Caenorhabdi... 39 0.003
ref|NP_496261.1| (NM_063860) serine/threonine kinase [Caeno... 39 0.005
ref|NP_509835.1| (NM_077434) IG (immunoglobulin) superfamil... 39 0.005
ref|NP_015088.1| (NC_001148) Hypothetical ORF; Ypl236cp [Sa... 39 0.005
ref|NP_011049.2| (NC_001137) plasma membrane-bound casein k... 39 0.005
ref|NP_500772.1| (NM_068371) protein kinase [Caenorhabditis... 38 0.006
ref|NP_497916.1| (NM_065515) serine/threonine kinase [Caeno... 38 0.006
ref|NP_509836.1| (NM_077435) IG (immunoglobulin) superfamil... 38 0.006
ref|NP_505456.1| (NM_073055) serine/threonine kinase [Caeno... 38 0.006
ref|NP_499868.1| (NM_067467) protein kinase [Caenorhabditis... 38 0.008
ref|NP_510348.1| (NM_077947) serine/threonine kinase [Caeno... 38 0.008
ref|NP_510755.1| (NM_078354) guanylate cyclase receptor [Ca... 38 0.008
ref|NP_503110.1| (NM_070709) guanylate cyclase (2 domains)... 38 0.008
ref|NP_507962.1| (NM_075561) protein tyrosine kinase [Caeno... 37 0.010
ref|NP_499906.1| (NM_067505) serine/threonine-protein kinas... 37 0.010
ref|NP_501778.1| (NM_069377) serine/threonine kinase [Caeno... 37 0.010
ref|NP_500614.1| (NM_068213) ser/thr protein kinase [Caenor... 37 0.013
ref|NP_011704.1| (NC_001139) checkpoint gene involved in pe... 37 0.013
ref|NP_510698.1| (NM_078297) protein kinase [Caenorhabditis... 37 0.017
ref|NP_496038.1| (NM_063637) guanylate cyclase [Caenorhabdi... 37 0.017
ref|NP_495378.1| (NM_062977) protein kinase [Caenorhabditis... 36 0.023
Alignments
>ref|NP_499783.1| (NM_067382) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 292
Score = 466 bits (1200), Expect = e-132
Identities = 217/288 (75%), Positives = 257/288 (88%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
M Y+K+EKIGEGTYGTVFKA+N+++ EIVALKRVRLDDDDEGVPSSALREIC+L+ELKH
Sbjct: 1 MLNYDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKH 60
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSR 120
+N+VRL+DV+HS+ KLTLVFE+CDQDLKK+FDS NG +D + +S M QLL+GL+FCH+
Sbjct: 61 RNVVRLYDVVHSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTARSLMLQLLRGLSFCHAH 120
Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
+VLHRDLKPQNLLIN NG LKLADFGLARAFG+PVRC+SAEVVTLWYRPPDVLFGAKLY+
Sbjct: 121 HVLHRDLKPQNLLINTNGTLKLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYN 180
Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYP 240
TSIDMWSAGCIFAE++NAGRPLFPG DVDDQLKRIF+ LG+P+E+ WP++T+LPDYKPYP
Sbjct: 181 TSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPSITQLPDYKPYP 240
Query: 241 MYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
+Y T++ +VP LN+ GRDLLQ LL CNP RI AD AL+H YFAD
Sbjct: 241 IYHPTLTWSQIVPNLNSRGRDLLQKLLVCNPAGRIDADAALRHAYFAD 288
>ref|NP_015294.1| (NC_001148) involved in phosphate and glycogen metabolism and cell
cycle progression; Pho85p [Saccharomyces cerevisiae]
Length = 305
Score = 327 bits (839), Expect = 4e-90
Identities = 166/297 (55%), Positives = 212/297 (70%), Gaps = 12/297 (4%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
++++LEK+G GTY TV+K N+ T VALK V+LD + EG PS+A+REI L+KELKH+N
Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64
Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-----GDLDPEIVKSFMYQLLKGLAFC 117
IVRL+DV+H++ KLTLVFEF D DLKKY DS L+ +VK F +QLL+GLAFC
Sbjct: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124
Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177
H +LHRDLKPQNLLIN+ G+LKL DFGLARAFGIPV +S+EVVTLWYR PDVL G++
Sbjct: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184
Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYK 237
YSTSID+WS GCI AE+ G+PLFPG + ++QLK IF ++GTP E WP++TKLP Y
Sbjct: 185 TYSTSIDIWSCGCILAEMI-TGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243
Query: 238 PYPMYPATMSLVNVV-----PKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADF 289
P L V+ L+ D L LL+ NP R+ A +AL HP+FA++
Sbjct: 244 PNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEY 300
>ref|NP_009718.1| (NC_001134) Catalytic subunit of the main cell cycle
cyclin-dependent kinase; Cdc28p [Saccharomyces
cerevisiae]
Length = 298
Score = 325 bits (832), Expect = 2e-89
Identities = 166/295 (56%), Positives = 211/295 (71%), Gaps = 9/295 (3%)
Query: 1 MQKYEKLEKIGEGTYGTVFKA---KNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKE 57
+ Y++LEK+GEGTYG V+KA + +VALK++RL+ +DEGVPS+A+REI LLKE
Sbjct: 5 LANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKE 64
Query: 58 LKHKNIVRLHDVLHSDK-KLTLVFEFCDQDLKKYFDSCNGD--LDPEIVKSFMYQLLKGL 114
LK NIVRL+D++HSD KL LVFEF D DLK+Y + D L +IVK FM QL KG+
Sbjct: 65 LKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQLCKGI 124
Query: 115 AFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174
A+CHS +LHRDLKPQNLLIN++G LKL DFGLARAFG+P+R Y+ E+VTLWYR P+VL
Sbjct: 125 AYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLL 184
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLP 234
G K YST +D WS GCIFAE+ N +P+F G+ DQ+ +IFR+LGTP E WP + LP
Sbjct: 185 GGKQYSTGVDTWSIGCIFAEMCNR-KPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIVYLP 243
Query: 235 DYKP-YPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
D+KP +P + L VVP L+ G DLL LL +P+ RI A A HPYF +
Sbjct: 244 DFKPSFPQW-RRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQE 297
>ref|NP_501373.1| (NM_068972) C07G1.3b.p [Caenorhabditis elegans]
Length = 700
Score = 305 bits (780), Expect = 3e-83
Identities = 149/286 (52%), Positives = 202/286 (70%), Gaps = 3/286 (1%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
++ YEKL+K+GEGTY TVF+ ++ T++ VALK +RL+ + EG P +A+RE+ LL+ L+H
Sbjct: 358 LETYEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQE-EGAPCTAIREVSLLRNLRH 416
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSR 120
N+V LHD++H+D+ LTLVFE+ D+DLK+Y DSCN + ++ F+YQLL+GLA+CH R
Sbjct: 417 ANVVTLHDIIHTDRLLTLVFEYVDRDLKQYMDSCNNAMQMNNIRLFLYQLLRGLAYCHQR 476
Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
VLHRDLKPQNLLI GELKLADFGLARA +P + YS EVVTLWYRPPDVL G+ YS
Sbjct: 477 RVLHRDLKPQNLLITAKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTDYS 536
Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYP 240
T IDMW GCI E+ AGR LFPG +QL IFR LG+P ++ P + + P + PY
Sbjct: 537 THIDMWGVGCILFEMI-AGRALFPGGTPTEQLGLIFRTLGSPRPDRHPTICEKPTFYPYA 595
Query: 241 -MYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
+ L +P+++A G +LL L+ R+ A EA++HP+
Sbjct: 596 NRHYNPDPLCRQIPRIDAHGFELLMKFLQYEGKDRVSAAEAVKHPF 641
>ref|NP_501372.1| (NM_068971) ser/thr protein kinase [Caenorhabditis elegans]
Length = 577
Score = 305 bits (780), Expect = 3e-83
Identities = 149/286 (52%), Positives = 202/286 (70%), Gaps = 3/286 (1%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
++ YEKL+K+GEGTY TVF+ ++ T++ VALK +RL+ + EG P +A+RE+ LL+ L+H
Sbjct: 235 LETYEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQE-EGAPCTAIREVSLLRNLRH 293
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSR 120
N+V LHD++H+D+ LTLVFE+ D+DLK+Y DSCN + ++ F+YQLL+GLA+CH R
Sbjct: 294 ANVVTLHDIIHTDRLLTLVFEYVDRDLKQYMDSCNNAMQMNNIRLFLYQLLRGLAYCHQR 353
Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
VLHRDLKPQNLLI GELKLADFGLARA +P + YS EVVTLWYRPPDVL G+ YS
Sbjct: 354 RVLHRDLKPQNLLITAKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTDYS 413
Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYP 240
T IDMW GCI E+ AGR LFPG +QL IFR LG+P ++ P + + P + PY
Sbjct: 414 THIDMWGVGCILFEMI-AGRALFPGGTPTEQLGLIFRTLGSPRPDRHPTICEKPTFYPYA 472
Query: 241 -MYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
+ L +P+++A G +LL L+ R+ A EA++HP+
Sbjct: 473 NRHYNPDPLCRQIPRIDAHGFELLMKFLQYEGKDRVSAAEAVKHPF 518
>ref|NP_499153.1| (NM_066752) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 332
Score = 303 bits (776), Expect = 8e-83
Identities = 155/295 (52%), Positives = 204/295 (68%), Gaps = 10/295 (3%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
+ + KLEKIGEGTYG V+K KNR T+ +VA+K++RL+ +DEGVPS+A+REI LLKEL+H
Sbjct: 19 LNDFTKLEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKELQH 78
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD--LDPEIVKSFMYQLLKGLAFCH 118
N+V L V+ + +L L+FEF DLK+Y D D L E +KS+ +Q+L+ + FCH
Sbjct: 79 PNVVGLEAVIMQENRLFLIFEFLSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAMCFCH 138
Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178
R V+HRDLKPQNLL++ NG +KLADFGLARA GIP+R Y+ EVVTLWYR P++L GA+
Sbjct: 139 QRRVIHRDLKPQNLLVDNNGAIKLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQR 198
Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYK- 237
YS +DMWS GCIFAE+A +PLF G+ D+L RIFR+LGTPTE +W + LPDYK
Sbjct: 199 YSMGVDMWSIGCIFAEMATK-KPLFQGDSEIDELFRIFRVLGTPTELEWNGVESLPDYKA 257
Query: 238 PYPMYPATMSLVNVVPK------LNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
+P + K L+ T LL+ LL +P R+ A +AL HPYF
Sbjct: 258 TFPKWRENFLRDKFYDKKTGKHLLDDTAFSLLEGLLIYDPSLRLNAKKALVHPYF 312
>ref|NP_490783.1| (NM_058382) protein kinase [Caenorhabditis elegans]
Length = 426
Score = 280 bits (716), Expect = 7e-76
Identities = 147/297 (49%), Positives = 196/297 (65%), Gaps = 14/297 (4%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y++++K+GEG+Y TV+K +++ IVALK ++L EG+P +A+RE LL+ L+H NI
Sbjct: 108 YKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQ-EGLPFTAIREASLLRNLRHANI 166
Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVL 123
V LHD+ + +LT VFE+ DL KY + LD +K ++QLL+GL FCH + +L
Sbjct: 167 VSLHDIFYQHHQLTFVFEYMKMDLSKYLEQNVYGLDSIDIKLLLFQLLRGLDFCHRKKIL 226
Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183
HRDLKPQNLL++ +G LKLADFGLARA +P R YS EVVTLWYRPPDVL G+ YSTS+
Sbjct: 227 HRDLKPQNLLLDEDGVLKLADFGLARAKSVPSRTYSHEVVTLWYRPPDVLMGSTDYSTSL 286
Query: 184 DMWSAGCIFAELANAGRPLFPGN------DVDDQLKRIFRLLGTPTEEQWPAMTKLPDYK 237
DMW GCIFAE+ G LFPG+ DQL IF + GTP E++WP + LP Y
Sbjct: 287 DMWGVGCIFAEIC-TGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPGYT 345
Query: 238 P--YPMYPATMSLVNVVP---KLNATGRDLLQNLLKCNPVQRICADEALQHPYFADF 289
P +P Y +S + V P K+ TG++LL LL+ P R+ A A+ HPYFA F
Sbjct: 346 PELFPRY-RELSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPYFASF 401
>ref|NP_491157.1| (NM_058756) protein kinase [Caenorhabditis elegans]
Length = 384
Score = 275 bits (702), Expect = 3e-74
Identities = 140/304 (46%), Positives = 196/304 (64%), Gaps = 21/304 (6%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
++ L +IGEGTYG VFKA + + ALK +R D D+EG+PS+ LREI +K+L+H N
Sbjct: 44 RFCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDN 103
Query: 63 IVRLHDVLH----------------SDKKLTLVFEFCDQDLK---KYFDSCNGDLDPEIV 103
IV L D+++ S+ KL +VFEF D+DLK + + N L P V
Sbjct: 104 IVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDRDLKNLLEMLEPTNSVLPPNYV 163
Query: 104 KSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV 163
KSFM+QLL L++CH R ++HRDLKPQN+L++ +G +K+ADFGLAR F P R Y+ EVV
Sbjct: 164 KSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRNYTHEVV 223
Query: 164 TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPT 223
TLWYRPP++L G++ YSTS+DMWS GCIF+E+A + +PLFPG QL +IF ++GTP
Sbjct: 224 TLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIA-SNKPLFPGECEISQLFKIFEIVGTPN 282
Query: 224 EEQWPAMTKLPDYKP-YPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQ 282
+ WP + P YK +P +P + + L G D+L+ +L+ P +R+ A AL
Sbjct: 283 IKSWPGVDSFPHYKAVFPQWPVNLKKLEETSCLTGNGLDVLREILRYPPERRLTAKGALS 342
Query: 283 HPYF 286
H YF
Sbjct: 343 HRYF 346
>ref|NP_497873.1| (NM_065472) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 684
Score = 227 bits (578), Expect = 7e-60
Identities = 127/298 (42%), Positives = 181/298 (60%), Gaps = 20/298 (6%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y L++IGEGTYG V+KA N T E VALKRVRL+++ EG P +A+REI +L++L HKNI
Sbjct: 311 YTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNI 370
Query: 64 VRLHDVLHSDKKLT----------LVFEFCDQDLKKYFDSCN-GDLDPEIVKSFMYQLLK 112
VRL D++ D + LVFE+ D DL +S D + + + S QLL+
Sbjct: 371 VRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLE 430
Query: 113 GLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172
GLA+ H+ LHRD+K N+L+N GELK+AD GLAR + R Y+ V+TLWYRPP++
Sbjct: 431 GLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVITLWYRPPEL 490
Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTK 232
L G + Y +ID+WS GC+ EL +PLF GN+ QL+ I ++ G+P + WP +T+
Sbjct: 491 LLGDERYGPAIDVWSTGCMLGELFTR-KPLFNGNNEFGQLELISKVCGSPNVDNWPELTE 549
Query: 233 LPDYKPYPMYPATMSLV-----NVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
L + + M + +++P+ DLL +L NP +RI A EAL HP+
Sbjct: 550 LVGWNTFRMKRTYQRRIREEFEHIMPR---EAVDLLDKMLTLNPEKRISAKEALNHPW 604
>ref|NP_495617.1| (NM_063216) CDC2 [Caenorhabditis elegans]
Length = 719
Score = 225 bits (574), Expect = 2e-59
Identities = 125/298 (41%), Positives = 180/298 (59%), Gaps = 11/298 (3%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREI-CLLKELK 59
+ +YE + ++ EGT+G V++ K++ T EIVALKR++++ + EG P +ALREI LLK
Sbjct: 353 IDEYECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAGN 412
Query: 60 HKNIVRLHDVLHSDK--KLTLVFEFCDQDLKKYFDSC---NGDLDPEIVKSFMYQLLKGL 114
H NIV + ++L K+ + EF + D+K D+ N K+ + QLL G+
Sbjct: 413 HPNIVNVKEILLGSNMDKIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGI 472
Query: 115 AFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174
H +LHRDLK NLL++ G LK+ADFGLAR +G P++ +++ VVTLWYR P++L
Sbjct: 473 EHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLL 532
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLP 234
G +LYST +DMWS GCI AE +PLFPG +Q+K+IF +GTPTE WP +T+L
Sbjct: 533 GTRLYSTPVDMWSVGCIMAEFILL-KPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELD 591
Query: 235 DYK--PYPMYPATMSLVNVVP--KLNATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
+K + YP + LN TG LL LL +P R A +AL H +F +
Sbjct: 592 GWKALTFEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWFTE 649
>ref|NP_509746.1| (NM_077345) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 763
Score = 212 bits (540), Expect = 2e-55
Identities = 129/303 (42%), Positives = 179/303 (58%), Gaps = 16/303 (5%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREI-CLLKELK 59
+ +Y L I EGTYG VF+ KN T E+VALKR +++ + EG P +ALREI LLK
Sbjct: 396 ISEYVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINMLLKAGA 455
Query: 60 HKNIVRLHDVLHSDKK--LTLVFEFCDQDLKKYFD---SCNGDLDPEIVKSFMYQLLKGL 114
H+NIV + ++L K + + E+ + D+K D S N K+ M QLL G+
Sbjct: 456 HENIVNVKEILVGSTKTEVYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLSGI 515
Query: 115 AFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG----IPVRC-YSAEVVTLWYRP 169
H +LHRDLK NLLI+ +G LK+ADFGLAR +G I R + VVTLWYR
Sbjct: 516 EHMHKLWILHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRS 575
Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPA 229
P++L K YST +DMWS GCI AE +P+F G+ +Q+ +IF+++GTPTE+ WP
Sbjct: 576 PELLLEPKTYSTPVDMWSIGCIMAEFIMM-KPMFQGDSEPNQVHQIFQMMGTPTEQIWPD 634
Query: 230 MTKLPDYKPY---PMYPATMSLVNVVPKL-NATGRDLLQNLLKCNPVQRICADEALQHPY 285
+ +L + P+ P + + KL N TG DLL +L NP R+ A EALQH +
Sbjct: 635 IKELKVWNMVEFPPVKPGQLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDW 694
Query: 286 FAD 288
F++
Sbjct: 695 FSE 697
>ref|NP_010175.1| (NC_001136) serine-threonine kinase, subunit of transcription
factor TFIIK, a subcomplex of TFIIH; Kin28p
[Saccharomyces cerevisiae]
Length = 306
Score = 208 bits (529), Expect = 3e-54
Identities = 110/292 (37%), Positives = 166/292 (56%), Gaps = 3/292 (1%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y K +K+GEGTY V+ T +A+K ++ + +G+ SA+RE+ L+E++H N
Sbjct: 6 EYTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPN 65
Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
++ L D+ + L LV EF DL+ + P +K++M L+G+ CH +
Sbjct: 66 VIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFI 125
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
LHRDLKP NLL + +G++K+ADFGLARA P ++ VVT WYR P++LFGAK Y+++
Sbjct: 126 LHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSA 185
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMY 242
ID+WS G IFAEL P PG + DQ++ FR LGTPT+ WP ++ Y +Y
Sbjct: 186 IDIWSVGVIFAELM-LRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIY 244
Query: 243 --PATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCPP 292
P+ L + D + +L NP +R A + L+ YF + PP
Sbjct: 245 PPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPP 296
>ref|NP_505823.1| (NM_073422) Eukaryotic protein kinase domain [Caenorhabditis
elegans]
Length = 353
Score = 204 bits (520), Expect = 4e-53
Identities = 113/297 (38%), Positives = 171/297 (57%), Gaps = 16/297 (5%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
M KY++L K+GEG+YG V+K KNRDT +IVA+K+ +DD + ALREI +LK+LKH
Sbjct: 1 MDKYDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKH 60
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSR 120
+N+V L +V ++KL LVFE CD+ + + ++ E++K +YQLL+ L FCHS
Sbjct: 61 QNLVGLIEVFKRNRKLHLVFELCDRTVLHELEKNPHGVNDELIKKIIYQLLEALKFCHSH 120
Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
+HRD+KP+N+ + RN ++KL DFG AR Y+ V T WYR P++L G Y
Sbjct: 121 KCIHRDVKPENIFLTRNDQVKLGDFGFARIIN-TTEMYTDYVATRWYRSPELLVGDVQYG 179
Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG--TPTE------EQWPAMTK 232
+D+W+ GC++AEL G L+PG DQL I + LG P Q+
Sbjct: 180 PPVDIWAVGCVYAELL-TGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQFFFGLS 238
Query: 233 LPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADF 289
+P+ P + P L + +P ++ D LQ + +P +R E + H F+++
Sbjct: 239 IPE--PEHLEP----LPSKLPNASSAQLDFLQKCFEMSPDRRFSCSELMLHGIFSNW 289
>ref|NP_012783.1| (NC_001143) putative kinase subunit of the kinase complex that
phosphorylates the RPO21 CTD (carboxy-terminal domain);
also called CTDK-I alpha subunit; Ctk1p [Saccharomyces
cerevisiae]
Length = 528
Score = 199 bits (507), Expect = 1e-51
Identities = 107/291 (36%), Positives = 164/291 (55%), Gaps = 8/291 (2%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y ++ ++GEGTYG V+KAKN +T ++VALK++RL + EG P +++REI LL+ H N+
Sbjct: 183 YLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNV 242
Query: 64 VRLHDVL-HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
+ +++ S K + ++FE+ D DL + + K QLL G+ + H +
Sbjct: 243 STIKEIMVESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKI 302
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
LHRD+K N+LI+ G LK+ DFGLAR Y+ V+TLWYRPP++L G Y T
Sbjct: 303 LHRDVKGSNILIDNQGNLKITDFGLARKMNSRAD-YTNRVITLWYRPPELLLGTTNYGTE 361
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMY 242
+DMW GC+ EL N +F G++ +Q++ IF+++GTPT WP + +P +
Sbjct: 362 VDMWGCGCLLVELFNK-TAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQ 420
Query: 243 PATMSLVNVVPKL-----NATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
T + N K ++ L NLL + +R A EALQ YF +
Sbjct: 421 QTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKE 471
>ref|NP_490952.1| (NM_058551) Y39G10AL.3.p [Caenorhabditis elegans]
Length = 308
Score = 190 bits (482), Expect = 9e-49
Identities = 109/291 (37%), Positives = 160/291 (54%), Gaps = 32/291 (10%)
Query: 2 QKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDE---GVPSSALREICLLKEL 58
++Y+ ++ +GEG + V+ A++ ++ E VA+K+++L +E G+ +A+REI LLKE+
Sbjct: 3 RRYDTIKHLGEGQFANVYLAQDLESGECVAIKKIKLGSREEAKDGINRTAIREIKLLKEI 62
Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCH 118
H NI+ L DV+ + LVF+F D DL+ L P +K+ Q+L GL F H
Sbjct: 63 HHDNIIGLRDVIGHRTSIQLVFDFMDTDLEHVIKDKEIILMPAHIKNITMQMLLGLEFLH 122
Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178
+LHRDLKP NLL+N+ G VVT WYR P++LFGA+
Sbjct: 123 VHWILHRDLKPNNLLMNKMG----------------------RVVTRWYRAPELLFGARS 160
Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDY-- 236
Y ID+WS GCI AEL P+FPG DQL +IF +LG PT E WP MT++ Y
Sbjct: 161 YGVGIDIWSVGCIIAELL-LRNPIFPGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVI 219
Query: 237 -KPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
KP Y A + P+ DL+ + +P++R+ ++LQ YF
Sbjct: 220 IKPQTEYMALNYYFSAAPQ---DLLDLMAGMWTFDPIKRLTCTQSLQMEYF 267
>ref|NP_009537.1| (NC_001134) Required for the arrest of cells in G(sub)1 in response
to pheromone and cell fusion during conjugation; Fus3p
[Saccharomyces cerevisiae]
Length = 353
Score = 186 bits (472), Expect = 1e-47
Identities = 115/302 (38%), Positives = 162/302 (53%), Gaps = 24/302 (7%)
Query: 10 IGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69
+GEG YG V A ++ T EIVA+K++ D LREI +LK KH+NI+ + ++
Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77
Query: 70 LHSDK-----KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLH 124
D ++ ++ E DL + + L + ++ F+YQ L+ + H NV+H
Sbjct: 78 QRPDSFENFNEVYIIQELMQTDLHRVISTQM--LSDDHIQYFIYQTLRAVKVLHGSNVIH 135
Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE----------VVTLWYRPPDVLF 174
RDLKP NLLIN N +LK+ DFGLAR S V T WYR P+V+
Sbjct: 136 RDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML 195
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLP 234
+ YS ++D+WS GCI AEL RP+FPG D QL IF ++GTP + + P
Sbjct: 196 TSAKYSRAMDVWSCGCILAELF-LRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESP 254
Query: 235 DYKPY----PMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFC 290
+ Y PMYPA L + P++N G DLLQ +L +P +RI A EAL+HPY +
Sbjct: 255 RAREYIKSLPMYPAA-PLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYH 313
Query: 291 PP 292
P
Sbjct: 314 DP 315
>ref|NP_015487.1| (NC_001148) CDC28/cdc2 related protein kinase; Sgv1p [Saccharomyces
cerevisiae]
Length = 657
Score = 186 bits (471), Expect = 2e-47
Identities = 111/318 (34%), Positives = 169/318 (52%), Gaps = 42/318 (13%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y + EK+G+GT+G V+K + +T VA+K++ + + + P +A REI +LK L HKNI
Sbjct: 60 YREDEKLGQGTFGEVYKGIHLETQRQVAMKKIIVSVEKDLFPITAQREITILKRLNHKNI 119
Query: 64 VRLHDVLHSD-------------KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQL 110
++L ++++ K ++ + DL + +L+ +K+ M Q+
Sbjct: 120 IKLIEMVYDHSPDITNAASSNLHKSFYMILPYMVADLSGVLHNPRINLEMCDIKNMMLQI 179
Query: 111 LKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARA-FGIPVRC-----------Y 158
L+GL + H +HRD+K N+LI+ NG LKLADFGLAR +G P Y
Sbjct: 180 LEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYPGGAGSGAKY 239
Query: 159 SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL 218
++ VVT WYR P+++ G K Y+T++D+W GC+FAE +P+ G DQ IF+L
Sbjct: 240 TSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEK-KPILQGKTDIDQGHVIFKL 298
Query: 219 LGTPTEEQWPAMTKLPDYKPYPMYPATMSLVNVVPK--------LNATGRDLLQNLLKCN 270
LGTPTEE W LP A ++ N P L+ TG D L LL +
Sbjct: 299 LGTPTEEDWAVARYLPG--------AELTTTNYKPTLRERFGKYLSETGLDFLGQLLALD 350
Query: 271 PVQRICADEALQHPYFAD 288
P +R+ A A HP+F +
Sbjct: 351 PYKRLTAMSAKHHPWFKE 368
>ref|NP_492493.1| (NM_060092) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 527
Score = 182 bits (463), Expect = 1e-46
Identities = 101/285 (35%), Positives = 165/285 (57%), Gaps = 4/285 (1%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y +++G+GT+G V AK DT + VA+KR++ + +LRE+ LK+L H N
Sbjct: 44 RYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMK-KKFYSWEEAMSLREVKSLKKLNHPN 102
Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
I++L +V+ + L VFEF ++L + + ++++ +YQ+L+GLAF H
Sbjct: 103 IIKLREVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGF 162
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
HRD+KP+N++ N +K+ADFGLAR Y+ V T WYR P++L + Y++
Sbjct: 163 FHRDMKPENIMCNGTELVKIADFGLAREIRSKPP-YTDYVSTRWYRAPEILLRSTSYNSP 221
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMY 242
IDMW+ GCI AEL RPLFPG DQL +I +LGTP +++WP +L +
Sbjct: 222 IDMWALGCIMAELYIL-RPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMNFRFQ 280
Query: 243 PATMS-LVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
+ + VV ++ G L+ +++ NP +R A+++L++ YF
Sbjct: 281 QVVATPMEQVVNTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYF 325
>ref|NP_510256.1| (NM_077855) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 342
Score = 181 bits (458), Expect = 6e-46
Identities = 99/299 (33%), Positives = 170/299 (56%), Gaps = 24/299 (8%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELK- 59
M+ ++ + +G+G YG V++ ++ + ALK++ + +EG+P S LREI ++K L
Sbjct: 35 MKDFQIHQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLAR 94
Query: 60 --HKNIVRLHDVLH------SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLL 111
H NI+ L V H + K+ ++ E CD DL + + + + K Q++
Sbjct: 95 KAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIPRGVPEQQAKHVTAQIV 154
Query: 112 KGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171
+ L F H+ +++HRDLKPQN+L+NR+ +KLADFGL++ + ++ VVTLWYR P+
Sbjct: 155 RALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYS-NTTAFTTLVVTLWYRSPE 213
Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP--- 228
VL Y++++DMW+ GCI +E+ +PLF G + +QL IF+ +GTP + WP
Sbjct: 214 VLL-QSYYNSTVDMWALGCIVSEI-YCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSES 271
Query: 229 --AMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
A P Y+P +L ++ P+++ + +Q L+ + +R+ A AL HP+
Sbjct: 272 VIARDSFPQYRP-------TNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPF 323
>ref|NP_510257.1| (NM_077856) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 406
Score = 179 bits (454), Expect = 2e-45
Identities = 98/292 (33%), Positives = 166/292 (56%), Gaps = 24/292 (8%)
Query: 8 EKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELK---HKNIV 64
+ +G+G YG V++ ++ + ALK++ + +EG+P S LREI ++K L H NI+
Sbjct: 106 QALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNII 165
Query: 65 RLHDVLH------SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCH 118
L V H + K+ ++ E CD DL + + + + K Q+++ L F H
Sbjct: 166 SLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIPRGVPEQQAKHVTAQIVRALDFLH 225
Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178
+ +++HRDLKPQN+L+NR+ +KLADFGL++ + ++ VVTLWYR P+VL
Sbjct: 226 THSIIHRDLKPQNILLNRDQTVKLADFGLSKEYS-NTTAFTTLVVTLWYRSPEVLL-QSY 283
Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP-----AMTKL 233
Y++++DMW+ GCI +E+ +PLF G + +QL IF+ +GTP + WP A
Sbjct: 284 YNSTVDMWALGCIVSEI-YCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSF 342
Query: 234 PDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
P Y+P +L ++ P+++ + +Q L+ + +R+ A AL HP+
Sbjct: 343 PQYRP-------TNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPF 387
>ref|NP_492357.1| (NM_059956) serine/threonine kinase [Caenorhabditis elegans]
Length = 622
Score = 174 bits (442), Expect = 4e-44
Identities = 115/328 (35%), Positives = 178/328 (54%), Gaps = 50/328 (15%)
Query: 4 YEKLEKIGEGTYGTVFKA-----KNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58
+E ++IG GTYG V+KA + ++ ALK + + +G SA REI L +EL
Sbjct: 26 FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMI----EGQGFSMSACREIALFREL 81
Query: 59 KHKNIVRLHDV-LHSDKKLTLVFEFCDQDLK---KYFDSCNGDLDP-----EIVKSFMYQ 109
+H N++ L V L ++KK+ L+ ++ + DL K+ + P +VK+ ++Q
Sbjct: 82 RHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTAKSKKVPIMVPRNMVKNILFQ 141
Query: 110 LLKGLAFCHSRNVLHRDLKPQNLLI------NRNGELKLADFGLARAFGIPVRCYSA--- 160
+L G+ + HS VLHRDLKP N+L+ + G +K+AD G +R + P++ +
Sbjct: 142 ILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDP 201
Query: 161 EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD---------DQ 211
VVT WYR P++L GAK Y+ +ID+W+ GCIFAEL A PLF + D DQ
Sbjct: 202 VVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTA-EPLFFCKEEDIKAQNPYHYDQ 260
Query: 212 LKRIFRLLGTPTEEQWPAMTKLPDYK-----------PYPMYPATMSLVNVVPKLNATGR 260
+KRIF LLG P++ WP M K+PD++ P +P ++ K+N+
Sbjct: 261 VKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRYFDKWKINSQSS 320
Query: 261 D--LLQNLLKCNPVQRICADEALQHPYF 286
LL LL +P +R+ +EA+ YF
Sbjct: 321 PYRLLVKLLTVDPTKRVSCEEAMNDIYF 348
>ref|NP_494946.1| (NM_062545) Ser/Thr protein kinase [Caenorhabditis elegans]
Length = 367
Score = 174 bits (440), Expect = 7e-44
Identities = 108/308 (35%), Positives = 163/308 (52%), Gaps = 25/308 (8%)
Query: 8 EKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67
E +G G YG V KA + + VA+K++ + +LRE+ +L+EL H+NI+ +
Sbjct: 61 ENVGAGAYGVVCKAMDTRNKKQVAIKKIPRAFTAHTLAKRSLREVRILRELLHENIIAVL 120
Query: 68 DVLHSD----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVL 123
D+ ++ K + LV + + DL + S L + + F YQLL+GL + HS ++
Sbjct: 121 DMFTAEGAHGKDIYLVMDLMETDLHQILHS-RQTLMEQHFQYFFYQLLRGLKYLHSAGII 179
Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRC---------YSAEVVTLWYRPPDVLF 174
HRDLKP NLL+N + L++ADFG+ARA+ + V T WYR P++LF
Sbjct: 180 HRDLKPSNLLLNGDCLLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRAPEILF 239
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTK-- 232
Y T +D+WSAGCIFAE+ R LFPG D Q+K I LG+P EE +T
Sbjct: 240 SMVEYDTKVDLWSAGCIFAEML-LRRQLFPGKDSVSQIKMIVYYLGSPEEEVINRITSDL 298
Query: 233 LPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADF--- 289
+ D + + PK + R+++ LL+ +P +R AD+ LQHP+ A +
Sbjct: 299 VRDSIEACGRKTPLPFSAIFPKASPEARNMVSYLLQISPWKRYSADQILQHPFMAQYHND 358
Query: 290 -----CPP 292
CPP
Sbjct: 359 QYEPLCPP 366
>ref|NP_011895.1| (NC_001140) Suppressor of lyt2; Slt2p [Saccharomyces cerevisiae]
Length = 484
Score = 173 bits (438), Expect = 1e-43
Identities = 111/306 (36%), Positives = 173/306 (56%), Gaps = 17/306 (5%)
Query: 2 QKYEKLEKIGEGTYGTVFKAKNRDTHE--IVALKRVRLDDDDEGVPSSALREICLLKELK 59
++++ +++IG G YG V A+ + E VA+K+V + +LRE+ LL+ +
Sbjct: 21 KRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFR 80
Query: 60 -HKNIVRLHD---VLHSDKKLTLVF---EFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLK 112
HKNI L+D V + D + ++ E + D+ + S D +SF YQ+L
Sbjct: 81 GHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQPLTDAHY-QSFTYQILC 139
Query: 113 GLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG-IPV---RCYSAEVVTLWYR 168
GL + HS +VLHRDLKP NLL+N + +LK+ DFGLAR + PV + + V T WYR
Sbjct: 140 GLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPVENSQFLTEYVATRWYR 199
Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228
P+++ + Y+ +ID+WSAGCI AE G+P+F G D +QL +I ++LGTP +E
Sbjct: 200 APEIMLSYQGYTKAIDVWSAGCILAEFL-GGKPIFKGKDYVNQLNQILQVLGTPPDETLR 258
Query: 229 AM--TKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
+ + DY + + VN+ P N+ DLL+ +L +P +RI DEAL+HPY
Sbjct: 259 RIGSKNVQDYIHQLGFIPKVPFVNLYPNANSQALDLLEQMLAFDPQKRITVDEALEHPYL 318
Query: 287 ADFCPP 292
+ + P
Sbjct: 319 SIWHDP 324
>ref|NP_497846.1| (NM_065445) serine/threonine kinase (CDC2/CDC28 subfamily)
[Caenorhabditis elegans]
Length = 444
Score = 172 bits (435), Expect = 3e-43
Identities = 107/300 (35%), Positives = 156/300 (51%), Gaps = 14/300 (4%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y L IGEG YG V A + T + VA+K++ + + LREI +L KH+N
Sbjct: 95 RYVNLSYIGEGAYGMVASALDTITRDRVAIKKIS-PFEHQTFCQRTLREIKILNRFKHEN 153
Query: 63 IVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFC 117
I+ + +++ S+ K + +V + DL K + L + V F+YQ+L+GL +
Sbjct: 154 IINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQK--LSNDHVCYFLYQILRGLKYI 211
Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLF 174
HS NVLHRDLKP NLL+N +LK+ DFGLAR + V T WYR P+++
Sbjct: 212 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIML 271
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAM--TK 232
+K Y+ SID+WS GCI AE+ + RPLFPG DQL I ++G+P+ + K
Sbjct: 272 NSKGYTKSIDVWSVGCILAEML-SNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDK 330
Query: 233 LPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCPP 292
Y + + P + DLL +L NP RI ++AL HPY + P
Sbjct: 331 ARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDP 390
>ref|NP_497847.1| (NM_065446) serine/threonine kinase (CDC2/CDC28 subfamily)
[Caenorhabditis elegans]
Length = 376
Score = 172 bits (435), Expect = 3e-43
Identities = 107/300 (35%), Positives = 156/300 (51%), Gaps = 14/300 (4%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y L IGEG YG V A + T + VA+K++ + + LREI +L KH+N
Sbjct: 27 RYVNLSYIGEGAYGMVASALDTITRDRVAIKKIS-PFEHQTFCQRTLREIKILNRFKHEN 85
Query: 63 IVRLHDVLHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFC 117
I+ + +++ S+ K + +V + DL K + L + V F+YQ+L+GL +
Sbjct: 86 IINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQK--LSNDHVCYFLYQILRGLKYI 143
Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP---VRCYSAEVVTLWYRPPDVLF 174
HS NVLHRDLKP NLL+N +LK+ DFGLAR + V T WYR P+++
Sbjct: 144 HSANVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIML 203
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAM--TK 232
+K Y+ SID+WS GCI AE+ + RPLFPG DQL I ++G+P+ + K
Sbjct: 204 NSKGYTKSIDVWSVGCILAEML-SNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDK 262
Query: 233 LPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCPP 292
Y + + P + DLL +L NP RI ++AL HPY + P
Sbjct: 263 ARSYLISLPHKPKQPWARLYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDP 322
>ref|NP_013214.1| (NC_001144) osmoregulation; Hog1p [Saccharomyces cerevisiae]
Length = 435
Score = 171 bits (433), Expect = 5e-43
Identities = 107/300 (35%), Positives = 158/300 (52%), Gaps = 23/300 (7%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y L +G G +G V A + T + VA+K++ + RE+ LLK L+H+N
Sbjct: 22 RYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHEN 81
Query: 63 IVRLHDVLHSD-KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRN 121
++ L D+ S + + V E DL + + L+ + V+ F+YQ+L+GL + HS
Sbjct: 82 LICLQDIFLSPLEDIYFVTELQGTDLHRLLQT--RPLEKQFVQYFLYQILRGLKYVHSAG 139
Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181
V+HRDLKP N+LIN N +LK+ DFGLAR + Y V T +YR P+++ + Y
Sbjct: 140 VIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGY---VSTRYYRAPEIMLTWQKYDV 196
Query: 182 SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP---------TEEQWPAMTK 232
+D+WSAGCIFAE+ G+PLFPG D Q I LLG+P +E +T
Sbjct: 197 EVDIWSAGCIFAEMIE-GKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTS 255
Query: 233 LPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCPP 292
LP P P + + DLL+ +L +P +RI A +AL HPY A + P
Sbjct: 256 LPHRDPIPFSERFKT-------VEPDAVDLLEKMLVFDPKKRITAADALAHPYSAPYHDP 308
>ref|NP_492907.1| (NM_060506) serine/threonine kinase (CDC2/CDKX subfamily) (2
domains) [Caenorhabditis elegans]
Length = 456
Score = 171 bits (432), Expect = 6e-43
Identities = 100/258 (38%), Positives = 144/258 (55%), Gaps = 28/258 (10%)
Query: 4 YEKLEKIGEGTYGTV-----------FKAKNRDTHEIVALKRVRLDDDDEGVPSSALREI 52
YEKL KIG+GT+G V FKA+ ++T +VALK++ ++++ EG P +ALRE+
Sbjct: 85 YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALREV 144
Query: 53 CLLKELKHKNIVRLHDVLHSDKKLT----------LVFEFCDQDLKKYFDSCNGDLDPEI 102
+L++LKH NI L +V + T LV C DL + +
Sbjct: 145 KMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMALCAHDLAGLLSNPKIRMSLVH 204
Query: 103 VKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF------GIPVR 156
+K+ M L+ GL H +LHRD+K N+LI+++G LKLADFGLAR F P
Sbjct: 205 IKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRP 264
Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216
Y+ VVTLWYRPP++L G + Y T ID+W AGCI AE+ +P+ G+ QL+ I
Sbjct: 265 LYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTR-QPIMQGDTEQKQLQLIS 323
Query: 217 RLLGTPTEEQWPAMTKLP 234
L G+ ++ WP +P
Sbjct: 324 GLCGSINKDVWPNCVNMP 341
>ref|NP_492906.1| (NM_060505) serine/threonine kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 489
Score = 171 bits (432), Expect = 6e-43
Identities = 100/258 (38%), Positives = 144/258 (55%), Gaps = 28/258 (10%)
Query: 4 YEKLEKIGEGTYGTV-----------FKAKNRDTHEIVALKRVRLDDDDEGVPSSALREI 52
YEKL KIG+GT+G V FKA+ ++T +VALK++ ++++ EG P +ALRE+
Sbjct: 85 YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALREV 144
Query: 53 CLLKELKHKNIVRLHDVLHSDKKLT----------LVFEFCDQDLKKYFDSCNGDLDPEI 102
+L++LKH NI L +V + T LV C DL + +
Sbjct: 145 KMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMALCAHDLAGLLSNPKIRMSLVH 204
Query: 103 VKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF------GIPVR 156
+K+ M L+ GL H +LHRD+K N+LI+++G LKLADFGLAR F P
Sbjct: 205 IKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRP 264
Query: 157 CYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIF 216
Y+ VVTLWYRPP++L G + Y T ID+W AGCI AE+ +P+ G+ QL+ I
Sbjct: 265 LYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTR-QPIMQGDTEQKQLQLIS 323
Query: 217 RLLGTPTEEQWPAMTKLP 234
L G+ ++ WP +P
Sbjct: 324 GLCGSINKDVWPNCVNMP 341
>ref|NP_011554.1| (NC_001139) Recovery from alpha factor arrest; Kss1p [Saccharomyces
cerevisiae]
Length = 368
Score = 169 bits (429), Expect = 1e-42
Identities = 118/311 (37%), Positives = 172/311 (54%), Gaps = 24/311 (7%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHK 61
+Y+ ++ IGEG YGTV A ++ + VA+K+++ V + +REI LL+ +H+
Sbjct: 12 QYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFV-TRTIREIKLLRYFHEHE 70
Query: 62 NIVRLHDVLH--SDKKLTLVF---EFCDQDLKKYFDSCNGD---LDPEIVKSFMYQLLKG 113
NI+ + D + S KL V+ E + DL+K ++ N L + V+ F YQ+L+
Sbjct: 71 NIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRA 130
Query: 114 LAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP-------VRCYSAEVVTLW 166
L HS V+HRD+KP NLL+N N +LK+ DFGLAR V + V T W
Sbjct: 131 LKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRW 190
Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226
YR P+++ + Y+T++D+WS GCI AE+ +G+PLFPG D QL I +LGTP+ E
Sbjct: 191 YRAPEIMLTFQEYTTAMDIWSCGCILAEMV-SGKPLFPGRDYHHQLWLILEVLGTPSFED 249
Query: 227 WPAMTKLPDYKPY----PMY-PATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEAL 281
+ + K K Y PM P V LN DLL +L+ NP +RI A EAL
Sbjct: 250 FNQI-KSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEAL 308
Query: 282 QHPYFADFCPP 292
+HPY A + P
Sbjct: 309 RHPYLAMYHDP 319
>ref|NP_015283.1| (NC_001148) Component of RNA polymerase II holoenzyme, involved in
RNA pol II carboxy-terminal domain phosphorylation.
Activity of the kinase (SSN3)/cyclin (SSN8) pair
required, along with SSN6 & TUP1, for transcriptional
repression of a-specific genes>
Length = 555
Score = 167 bits (423), Expect = 7e-42
Identities = 102/287 (35%), Positives = 164/287 (56%), Gaps = 31/287 (10%)
Query: 31 ALKRVRLDDDD------EGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCD 84
A+K+ + + D G+ SA RE+ L +EL +K++ L ++ K + +V+E+ +
Sbjct: 181 AIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAE 240
Query: 85 QDLKK--YFDSCNGD--LDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGEL 140
DL + +F S + P +V+S M+QLL G+++ H VLHRDLKP N+++ +G +
Sbjct: 241 HDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCV 300
Query: 141 KLADFGLARAF-GIPVRCYSAE--VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELAN 197
K+ D GLAR F + Y+ + VVT+WYR P++L GA+ Y+ ++D+WS GCIFAEL
Sbjct: 301 KIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIG 360
Query: 198 AGRPLFPGNDVD-----------DQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATM 246
+P+F G + +QL+RI +LGTP ++ WP + K P+Y +P
Sbjct: 361 L-QPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYR 419
Query: 247 SLVNVVPKLNATGRD-----LLQNLLKCNPVQRICADEALQHPYFAD 288
+ +A GRD LL +LL +P++RI A AL+H YF +
Sbjct: 420 DNL-ATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYFTE 465
Score = 29.6 bits (65), Expect = 2.1
Identities = 12/24 (50%), Positives = 17/24 (70%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNR 24
++KYE + I GTYG V+KAK +
Sbjct: 72 LEKYEVIGYIAAGTYGKVYKAKRQ 95
>ref|NP_498320.1| (NM_065919) C05D10.2.p [Caenorhabditis elegans]
Length = 470
Score = 167 bits (422), Expect = 8e-42
Identities = 102/309 (33%), Positives = 164/309 (53%), Gaps = 25/309 (8%)
Query: 2 QKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KH 60
+K++ +++G+G YG V+KA ++ + E VALK++ + RE+ L+E KH
Sbjct: 11 EKFDLQKRLGKGAYGIVWKAYDKRSRETVALKKIFDAFRNPTDSQRTFREVMFLQEFGKH 70
Query: 61 KNIVRLHDVLHSD--KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSF-MYQLLKGLAFC 117
N+++L+++ +D + + L FEF + DL G + ++ K + M QL + + F
Sbjct: 71 PNVIKLYNIFRADNDRDIYLAFEFMEADLHNVIKK--GSILKDVHKQYIMCQLFRAIRFL 128
Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--------GIPVRCYSAEVVTLWYRP 169
HS NVLHRDLKP N+L++ + +KLADFGLAR+ G + + V T WYR
Sbjct: 129 HSGNVLHRDLKPSNVLLDADCRVKLADFGLARSLSSLEDYPEGQKMPDLTEYVATRWYRS 188
Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP- 228
P++L AK Y+ +DMWS GCI AE+ GR LFPG+ +Q++RI + P+
Sbjct: 189 PEILLAAKRYTKGVDMWSLGCILAEML-IGRALFPGSSTINQIERIMNTIAKPSRADIAS 247
Query: 229 -----AMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQH 283
A + L P P + ++ + D++Q LL P +R+ ++ L H
Sbjct: 248 IGSHYAASVLEKMPQRPRKPLDL----IITQSQTAAIDMVQRLLIFAPQKRLTVEQCLVH 303
Query: 284 PYFADFCPP 292
PY F P
Sbjct: 304 PYVVQFHNP 312
>ref|NP_493243.1| (NM_060842) Eukaryotic protein kinase domain [Caenorhabditis
elegans]
Length = 362
Score = 165 bits (417), Expect = 3e-41
Identities = 108/301 (35%), Positives = 169/301 (55%), Gaps = 22/301 (7%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y + IG G++G VF AK T+E+VA+K+V D + RE+ ++++L H NI
Sbjct: 36 YYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKN------RELQIMRKLNHPNI 89
Query: 64 VRLHDVLHS--DKK----LTLVFEFCDQDL---KKYFDSCNGDLDPEIVKSFMYQLLKGL 114
V+L +S +KK L L+ E+ + + +++ + VK +MYQLL+ L
Sbjct: 90 VKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSL 149
Query: 115 AFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173
A+ HS + HRD+KPQNLLI+ +G LKL DFG A+ + + + + + +YR P+++
Sbjct: 150 AYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAK-YLVRNEPNVSYICSRYYRAPELI 208
Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
FGA Y+ SID+WSAG + AEL G+P+FPG+ DQL I ++LGTPT EQ +M
Sbjct: 209 FGATNYTNSIDVWSAGTVMAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMN-- 265
Query: 234 PDYKPYPMYPATMSLVNVVPKLN--ATGRDLLQNLLKCNPVQRICADEALQHPYFADFCP 291
P+YK + N V +++ A DL+ +++ P R A QH +F +
Sbjct: 266 PNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRN 325
Query: 292 P 292
P
Sbjct: 326 P 326
>ref|NP_494948.1| (NM_062547) Ser/Thr protein kinase [Caenorhabditis elegans]
Length = 691
Score = 163 bits (413), Expect = 9e-41
Identities = 102/305 (33%), Positives = 162/305 (52%), Gaps = 28/305 (9%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y E +G G +G V +A + ++ VA+K++ ++ ALREI + +EL H+N
Sbjct: 43 QYLAQENLGAGAFGVVCRAIDSKLNKQVAIKKITRVFKNQSTAKCALREIRITRELSHEN 102
Query: 63 IVRLHDVLH----SDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCH 118
I+ DVL S + + +V + + DL S N L+ + + F YQ+LKGL + H
Sbjct: 103 IINSTDVLMRESGSGQDIYIVMDLMETDLLSVLKS-NQTLNEKHFQYFFYQILKGLKYLH 161
Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC-------------YSAEVVTL 165
S ++HRDLKP NLL+N + LK+ADFG++R+ G + S V TL
Sbjct: 162 SAGIIHRDLKPANLLLNEDCSLKIADFGMSRS-GPSTKTTPNTSPNAHISGDLSQYVSTL 220
Query: 166 WYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225
WYR P++L Y T +D+WSAGCI AE+ RP+F G D Q++ + LGTP +E
Sbjct: 221 WYRAPEILLSMGEYDTQVDIWSAGCILAEMLLL-RPIFTGTDSYSQIQLLIEYLGTP-DE 278
Query: 226 QWPAMTKLPDYKPY-----PMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEA 280
Q K P + Y P P + + P + R+++ +L+ +P +R A++
Sbjct: 279 QVIRRIKSPSIRDYISSFGPKTP--LPFTAMFPNASIEARNIVSKMLQISPWKRFSAEQL 336
Query: 281 LQHPY 285
L+ P+
Sbjct: 337 LEEPF 341
>ref|NP_499829.1| (NM_067428) serine/threonine kinase (CDC2/CDC28 subfamily)
[Caenorhabditis elegans]
Length = 634
Score = 160 bits (405), Expect = 8e-40
Identities = 108/290 (37%), Positives = 156/290 (53%), Gaps = 13/290 (4%)
Query: 10 IGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69
IG G +G V+ + + + VALK++ + REI +L +H N++ L D+
Sbjct: 246 IGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDI 305
Query: 70 LHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLH 124
L ++L ++ E DL K S L P+ VK F+YQ+L+GL + H+ N+LH
Sbjct: 306 LQPANPSFFQELYVLTELMQSDLHKIIVSPQA-LTPDHVKVFVYQILRGLKYLHTANILH 364
Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRC-YSAEVVTLWYRPPDVLFGAKLYSTSI 183
RD+KP NLL+N N LK+ DFGLAR + R + EVVT +YR P++L GA+ Y+ ++
Sbjct: 365 RDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAV 424
Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAM---TKLPDYKPYP 240
D+WS GCIFAEL + LF +QL+ I LLGTP++E K +
Sbjct: 425 DIWSVGCIFAELLQR-KILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGL 483
Query: 241 MYPATMSLVNVV--PKLNATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
P T L + N DLLQ LL +P +RI +EALQH Y +
Sbjct: 484 RAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEE 533
>ref|NP_499831.1| (NM_067430) W06F12.1c.p [Caenorhabditis elegans]
Length = 437
Score = 160 bits (405), Expect = 8e-40
Identities = 108/290 (37%), Positives = 156/290 (53%), Gaps = 13/290 (4%)
Query: 10 IGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69
IG G +G V+ + + + VALK++ + REI +L +H N++ L D+
Sbjct: 49 IGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDI 108
Query: 70 LHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLH 124
L ++L ++ E DL K S L P+ VK F+YQ+L+GL + H+ N+LH
Sbjct: 109 LQPANPSFFQELYVLTELMQSDLHKIIVSPQA-LTPDHVKVFVYQILRGLKYLHTANILH 167
Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRC-YSAEVVTLWYRPPDVLFGAKLYSTSI 183
RD+KP NLL+N N LK+ DFGLAR + R + EVVT +YR P++L GA+ Y+ ++
Sbjct: 168 RDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAV 227
Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAM---TKLPDYKPYP 240
D+WS GCIFAEL + LF +QL+ I LLGTP++E K +
Sbjct: 228 DIWSVGCIFAELLQR-KILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGL 286
Query: 241 MYPATMSLVNVV--PKLNATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
P T L + N DLLQ LL +P +RI +EALQH Y +
Sbjct: 287 RAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEE 336
>ref|NP_499830.1| (NM_067429) W06F12.1b.p [Caenorhabditis elegans]
Length = 462
Score = 160 bits (405), Expect = 8e-40
Identities = 108/290 (37%), Positives = 156/290 (53%), Gaps = 13/290 (4%)
Query: 10 IGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDV 69
IG G +G V+ + + + VALK++ + REI +L +H N++ L D+
Sbjct: 74 IGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDI 133
Query: 70 LHSD-----KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLH 124
L ++L ++ E DL K S L P+ VK F+YQ+L+GL + H+ N+LH
Sbjct: 134 LQPANPSFFQELYVLTELMQSDLHKIIVSPQA-LTPDHVKVFVYQILRGLKYLHTANILH 192
Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRC-YSAEVVTLWYRPPDVLFGAKLYSTSI 183
RD+KP NLL+N N LK+ DFGLAR + R + EVVT +YR P++L GA+ Y+ ++
Sbjct: 193 RDIKPGNLLVNSNCILKICDFGLARTWDQRDRLNMTHEVVTQYYRAPELLMGARRYTGAV 252
Query: 184 DMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAM---TKLPDYKPYP 240
D+WS GCIFAEL + LF +QL+ I LLGTP++E K +
Sbjct: 253 DIWSVGCIFAELLQR-KILFQAAGPIEQLQMIIDLLGTPSQEAMKYACEGAKNHVLRAGL 311
Query: 241 MYPATMSLVNVV--PKLNATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
P T L + N DLLQ LL +P +RI +EALQH Y +
Sbjct: 312 RAPDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYLEE 361
>ref|NP_510429.1| (NM_078028) glycogen synthase kinase (CDC2/CDKX subfamily)
[Caenorhabditis elegans]
Length = 367
Score = 159 bits (402), Expect = 2e-39
Identities = 100/298 (33%), Positives = 161/298 (53%), Gaps = 18/298 (6%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
++ L+ IG G++G V+KA R+ E +A+K++++DD + RE+ ++ E+ H N
Sbjct: 36 QFTNLQLIGTGSFGAVYKAVLRENDEPIAIKKIKVDDRFKS------RELTIMHEMDHPN 89
Query: 63 IVRL--HDVLHSDKKLTLVFEFCDQDLK---KYFDSCNGDLDPEIVKSFMYQLLKGLAFC 117
I+RL + V+ + L V EF +DL + F + + +K +M+QLL+G+ F
Sbjct: 90 IIRLLYYYVMQQENCLNFVMEFMPKDLAYVHRQFAHNDKQMPAYSIKLYMFQLLRGIGFL 149
Query: 118 HSRNVLHRDLKPQNLLINR-NGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLF 174
H N++HRD+KP+NLL++ NG LK+ DFG A+ P Y + + +YR P+++F
Sbjct: 150 HLHNIVHRDIKPKNLLVDESNGILKICDFGSAKRLEKNEPNITY---ICSRYYRAPELIF 206
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLP 234
G+K Y TSID WS G + EL + P+F + D L + GTP++E
Sbjct: 207 GSKNYDTSIDTWSVGTVVGELLH-NSPIFLADSAVDILALQIKAFGTPSKEDMAKWNYEY 265
Query: 235 DYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCPP 292
+ PY + KL+ + +LL +L+K +P RI EAL PYF D P
Sbjct: 266 VHIPYDTITGVGIQKFIGRKLSLSTLELLNSLMKMDPKLRIKPYEALTLPYFDDLRDP 323
>ref|NP_501073.1| (NM_068672) MAP kinase [Caenorhabditis elegans]
Length = 463
Score = 159 bits (401), Expect = 2e-39
Identities = 109/307 (35%), Positives = 155/307 (49%), Gaps = 31/307 (10%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
+++Y+ L IG G G V A + +E VA+K++ + A RE+ L+ + H
Sbjct: 116 LKRYQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAKRAYRELKLMSLVNH 175
Query: 61 KNIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGL 114
KNI+ + + KKL +V E D +L + DLD E + +YQ+L G+
Sbjct: 176 KNIIGILNCFTPQKKLDEFNDLYIVMELMDANLCQVIQM---DLDHERLSYLLYQMLCGI 232
Query: 115 AFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174
HS ++HRDLKP N+++ + LK+ DFGLAR I + VVT +YR P+V+
Sbjct: 233 RHLHSAGIIHRDLKPSNIVVRSDCTLKILDFGLART-AIEAFMMTPYVVTRYYRAPEVIL 291
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP----TEEQWPAM 230
G Y ++D+WS GCIF EL GR LFPG D DQ RI LGTP E P +
Sbjct: 292 GMG-YKENVDVWSIGCIFGELIR-GRVLFPGGDHIDQWTRIIEQLGTPDRSFLERLQPTV 349
Query: 231 TKL----PDYKPYP--------MYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICAD 278
P Y+ P M+P T + A RDLL +L +P +RI D
Sbjct: 350 RNYVENRPRYQATPFEVLFSDNMFPMTADSSRLT---GAQARDLLSRMLVIDPERRISVD 406
Query: 279 EALQHPY 285
+AL+HPY
Sbjct: 407 DALRHPY 413
>ref|NP_502232.1| (NM_069831) serine/threonine kinase (2 domains) [Caenorhabditis
elegans]
Length = 305
Score = 155 bits (393), Expect = 2e-38
Identities = 85/236 (36%), Positives = 134/236 (56%), Gaps = 26/236 (11%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+YE ++ G G +G V A++ T + VA+KR+ + + + S REI L+ L H+N
Sbjct: 7 RYETIQVAGRGAFGLVVIARDTLTSKRVAIKRIMVPNVSK---VSLAREISCLRNLHHRN 63
Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMY-QLLKGLAFCHSRN 121
I++L D S +++V E E+ ++ Y Q+L G+A+ HS+
Sbjct: 64 ILKLLDCFPSADLMSIVTE-------------------EVPYTWYYTQILSGIAYLHSKE 104
Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLY 179
++HRD+KP+N+L+ +K+ADFG A + P + Y V T WYR P++LFG+K Y
Sbjct: 105 IMHRDIKPENILVTSRNVVKIADFGQACFYMPKDPNQEYDVNVATRWYRAPELLFGSKKY 164
Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPD 235
+D+W+ GCI AEL G+P+FPG +Q+ IF +LGTP E+ WP +PD
Sbjct: 165 KPDVDIWAIGCILAELVR-GKPIFPGRSELEQISIIFGVLGTPNEDNWPNWRTMPD 219
>ref|NP_499922.1| (NM_067521) protein kinase [Caenorhabditis elegans]
Length = 390
Score = 150 bits (379), Expect = 8e-37
Identities = 109/305 (35%), Positives = 156/305 (50%), Gaps = 26/305 (8%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y L + G GTV A + T + VA+K+++ A RE LL +KH N
Sbjct: 37 RYVNLSFLNAGAQGTVVMADDLVTTQRVAIKKMQQPFVMTMSAKRAYREFILLTTIKHPN 96
Query: 63 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAF 116
I+RL + D L+ LV E +L + LD + + F+YQ L +
Sbjct: 97 IIRLLNAFTPDTSLSTFREVYLVMELMTHNLHEVIHRLR--LDHKTLSFFVYQSLCAIKH 154
Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE-VVTLWYRPPDVLFG 175
H+ V+HRDLKP N+++N LK+ DFGLAR + ++ VVT +YR P+V+ G
Sbjct: 155 LHNSGVIHRDLKPSNIVVNDRCVLKVLDFGLARKKNVDTSMRMSDYVVTRYYRAPEVILG 214
Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE------QWPA 229
YS +D+WS GCIFAE+ N LFPG D DQ +I+ +LGTP + Q A
Sbjct: 215 LP-YSEKVDIWSVGCIFAEMIN-HTVLFPGKDRIDQWTKIYSVLGTPDDHFISQLGQSAA 272
Query: 230 M--TKLPDYKP---YPMYPATMSLVNVV-PKLNAT---GRDLLQNLLKCNPVQRICADEA 280
M LP ++ + P T L P+++ T RDLL N+LK NP +R ++A
Sbjct: 273 MYVRSLPRHQARAFSEIVPDTNFLPETENPRVHLTPHVARDLLFNMLKINPEERYSVEDA 332
Query: 281 LQHPY 285
L HPY
Sbjct: 333 LNHPY 337
>ref|NP_501363.1| (NM_068962) protein kinase [Caenorhabditis elegans]
Length = 474
Score = 150 bits (379), Expect = 8e-37
Identities = 108/309 (34%), Positives = 161/309 (51%), Gaps = 27/309 (8%)
Query: 7 LEKIGEGTYGTVFK--AKNRD-THEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
+E +G G++G V K A RD VA+K++R D RE LL+ ++H NI
Sbjct: 121 IEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNI 180
Query: 64 VRLHDVLHSDKK-----LTLVFEFCD----QDLKKYFDSCNGDLDPEIVKSFMYQLLKGL 114
+ D+ D++ + +V EF Q LK+ D L E +K +YQ+++ L
Sbjct: 181 ICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIKFIIYQIIRAL 240
Query: 115 AFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174
+ HS N++HRDLKP NL + + +L + DFGLAR+ + V T WYR P+V++
Sbjct: 241 KYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIY 300
Query: 175 -GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
Y+ DMWS GCI AEL G PLFPG++ + Q +RI +L G+P EE +TK+
Sbjct: 301 WKIDSYTNLADMWSLGCIAAELL-TGEPLFPGDEPNAQYQRITQLCGSPDEE---LLTKI 356
Query: 234 PDYKPYPMYPATMSLV--------NVVPKLNATGR--DLLQNLLKCNPVQRICADEALQH 283
+ + S +V N + DLL+ LL +P +RI +EA+QH
Sbjct: 357 ENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQH 416
Query: 284 PYFADFCPP 292
PY A+F P
Sbjct: 417 PYLAEFSLP 425
>ref|NP_013859.1| (NC_001145) Required for Ime1p phosphorylation, association of the
Ime1p-Ume6p meiotic activator, early meiotic gene
expression, and sporulation; Rim11p [Saccharomyces
cerevisiae]
Length = 370
Score = 148 bits (374), Expect = 3e-36
Identities = 101/295 (34%), Positives = 156/295 (52%), Gaps = 31/295 (10%)
Query: 8 EKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLH 67
E +G G++G VF ++T+E VA+K+V D + RE+ ++K L H NI+ L
Sbjct: 43 EVVGHGSFGVVFATVIQETNEKVAIKKVLQDKRFKN------RELEIMKMLSHINIIDLK 96
Query: 68 DVLHSDKK-----LTLVFEFCDQDLK---KYFDSCNGDLDPEIVKSFMYQLLKGLAFCHS 119
+ L L+ E+ Q L ++F + +K +M+QL K L + H
Sbjct: 97 YFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHH 156
Query: 120 -RNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 177
NV HRD+KPQNLL++ LKL DFG A+ P + + + +YR P+++FGA
Sbjct: 157 FANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLK-PTEPNVSYICSRYYRAPELIFGAT 215
Query: 178 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMT------ 231
Y+ ID+WS+GC+ AEL G+P+FPG DQL I ++LGTP++++ +M
Sbjct: 216 NYTNQIDIWSSGCVMAELL-LGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEH 274
Query: 232 KLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
K P KP P L V K + + L ++LK +P++R A + L PYF
Sbjct: 275 KFPQIKPIP-------LSRVFKKEDDQTVEFLADVLKYDPLERFNALQCLCSPYF 322
>ref|NP_501365.1| (NM_068964) ser/thr kinases [Caenorhabditis elegans]
Length = 377
Score = 148 bits (373), Expect = 4e-36
Identities = 96/292 (32%), Positives = 150/292 (50%), Gaps = 10/292 (3%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y L IG G YGTV A+ + VA+K+ RE+ LL+ + H+NI
Sbjct: 35 YINLTPIGTGAYGTVCAAECTRSGTRVAIKKFNRPFQSIIHARRTYRELRLLRCMCHENI 94
Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN----GDLDPEIVKSFMYQLLKGLAFCHS 119
+ L DV ++ + + + + D N L+ + ++ +YQ+L+GL + HS
Sbjct: 95 IDLLDVFTPNENVNDIEDVYFVSMLMGADLSNILKIQRLNDDHIQFLVYQILRGLKYIHS 154
Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179
+++HRDLKP N+ +N + ELK+ DFGLAR + Y V T WYR P+++ Y
Sbjct: 155 ADIIHRDLKPSNIAVNEDCELKILDFGLARQTDSEMTGY---VATRWYRAPEIMLNWMHY 211
Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMT--KLPDYK 237
+ ++D+WS GCI AEL G+ LFPG+D DQL RI + GTP EE ++ + +Y
Sbjct: 212 TQTVDVWSVGCILAELI-TGKTLFPGSDHIDQLTRIMSVTGTPDEEFLKKISSEEARNYI 270
Query: 238 PYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADF 289
+ + DLL+ +L +P +R A EA++H Y A +
Sbjct: 271 RNLPKMTRRDFKRLFAQATPQAIDLLEKMLHLDPDRRPTAKEAMEHEYLAAY 322
>ref|NP_015379.1| (NC_001148) involved in sporulation; Smk1p [Saccharomyces
cerevisiae]
Length = 388
Score = 146 bits (369), Expect = 1e-35
Identities = 105/312 (33%), Positives = 160/312 (50%), Gaps = 29/312 (9%)
Query: 4 YEKLEKIGEGTYGTV--FKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELK-H 60
YE ++ +G+G YGTV K K R +A+K++ + E + A+RE+ + K H
Sbjct: 38 YEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGH 97
Query: 61 KNIVRLHDVLHSDKK----LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAF 116
KNIV L D+ L E D DL K S + L +K F+YQ+L GL +
Sbjct: 98 KNIVNLIDLEIVTSSPYDGLYCYQELIDYDLAKVIHS-SVQLSEFHIKYFLYQILCGLKY 156
Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP-VRCYSA-------EVVTLWYR 168
HS +V+HRDLKP N+L NG LK+ DFGLAR +C+S V T WYR
Sbjct: 157 IHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYR 216
Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228
P++L + YS S+D+W+ GCI AE A +P+F G D Q+ I ++LGTP ++
Sbjct: 217 APELLLSNQPYSKSVDIWAVGCILAEF-YARKPVFMGRDSMHQIFEIIKVLGTPDKD--- 272
Query: 229 AMTKLPDYKPY--------PMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEA 280
+ K K + P+Y + N+ P + +L+++LL + R+ ++A
Sbjct: 273 ILIKFGTIKAWNLGKNSNNPVY-KKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQA 331
Query: 281 LQHPYFADFCPP 292
+ HP+ + P
Sbjct: 332 ISHPFLNEVRKP 343
>ref|NP_012761.1| (NC_001143) Hypothetical ORF; Ykl161cp [Saccharomyces cerevisiae]
Length = 433
Score = 144 bits (363), Expect = 6e-35
Identities = 98/296 (33%), Positives = 162/296 (54%), Gaps = 21/296 (7%)
Query: 9 KIGEGTYGTV----FKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELK-HKNI 63
KIG G++ + + N +TH VA++++ ++ LRE+ LL+ L+ H NI
Sbjct: 28 KIGRGSHSLICSSTYTESNEETH--VAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHPNI 85
Query: 64 VRLHD---VLHSDKKLTLVF---EFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFC 117
V L D V + + L V+ E + DL + S L+ +SF+YQ+L L +
Sbjct: 86 VWLFDTDIVFYPNGALNGVYLYEELMECDLSQIIRS-EQRLEDAHFQSFIYQILCALKYI 144
Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVL 173
HS NVLH DLKP+NLL+N + +LK+ +FGL+ ++ + + ++WY+ P++L
Sbjct: 145 HSANVLHCDLKPKNLLVNSDCQLKICNFGLSCSYSENHKVNDGFIKGYITSIWYKAPEIL 204
Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE--QWPAMT 231
+ + ++D+WS GCI AEL +P+F G D D L I ++LGTP EE Q A
Sbjct: 205 LNYQECTKAVDIWSTGCILAELLGR-KPMFEGKDYVDHLNHILQILGTPPEETLQEIASQ 263
Query: 232 KLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFA 287
K+ +Y S +++P N +LL+ +L+ +P +RI ++AL+HPY +
Sbjct: 264 KVYNYIFQFGNIPGRSFESILPGANPEALELLKKMLEFDPKKRITVEDALEHPYLS 319
>ref|NP_501364.1| (NM_068963) protein kinase [Caenorhabditis elegans]
Length = 448
Score = 142 bits (357), Expect = 3e-34
Identities = 102/345 (29%), Positives = 154/345 (44%), Gaps = 60/345 (17%)
Query: 2 QKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61
Q Y L+ +GEG YG V A+ T + VA+K+ RE+ LL+ L+H
Sbjct: 47 QWYNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQHD 106
Query: 62 NIVRLHDVLHSD------KKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLA 115
N++ + DV D + V DL+ L E ++ +YQ+L+GL
Sbjct: 107 NVLEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIMKIQR--LTDEQIQLLIYQVLRGLK 164
Query: 116 FC-----------------------------HSRNVLHRDLKPQNLLINRNGELK----- 141
+ HS ++HRDLKP N+ +N E+K
Sbjct: 165 YMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVNERCEVKVFLSF 224
Query: 142 ------------LADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAG 189
+ DFGLARA + Y V T WYR P+++ Y+ ++D+WS G
Sbjct: 225 SQLSFLILSFFKILDFGLARAQDAEMTGY---VATRWYRAPEIMLNWMHYTQTVDVWSVG 281
Query: 190 CIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAM--TKLPDYKPYPMYPATMS 247
CI AEL +GRPLFPG+D DQL +I ++GTP EE W + + +Y
Sbjct: 282 CILAELV-SGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYIKNRSPIIRQD 340
Query: 248 LVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCPP 292
V + P + +LL+ +L +P +RI AL+H Y ++ P
Sbjct: 341 FVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYLREYSVP 385
>ref|NP_510009.1| (NM_077608) serine/threonine kinase (CDC2/CDC28 subfamily)
[Caenorhabditis elegans]
Length = 472
Score = 142 bits (357), Expect = 3e-34
Identities = 81/237 (34%), Positives = 127/237 (53%), Gaps = 14/237 (5%)
Query: 2 QKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61
+ YE + IG G +G V +A +++ VA+K+V + LREI +L+ + H
Sbjct: 80 ETYEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHP 139
Query: 62 NIVRLHDVLHSDKKLT----LVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFC 117
NIV L D+ + L LV + +L L+ + +F+ QLL+GL +
Sbjct: 140 NIVPLRDIFRTKGPLGIDVFLVMDLMQNNLHHIIYGNEDPLEEHYINAFLGQLLRGLEYL 199
Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR-------CY--SAEVVTLWYR 168
H+ + HRDLKP NLL+N++G L++ADFG+A+ + CY + V TL YR
Sbjct: 200 HAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYR 259
Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE 225
P++LF +ST++DMW+ GCIF E+ + PG V Q+K + +LG P +E
Sbjct: 260 APELLFVLPEHSTAVDMWAVGCIFGEMV-IRNEILPGRSVQGQIKMLLTMLGQPPQE 315
>ref|NP_500384.1| (NM_067983) protein kinase [Caenorhabditis elegans]
Length = 375
Score = 140 bits (354), Expect = 7e-34
Identities = 104/308 (33%), Positives = 149/308 (47%), Gaps = 28/308 (9%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y L+ + G G V A + T + VA+K+++ A RE LL LKH N
Sbjct: 28 RYVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILLTTLKHPN 87
Query: 63 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAF 116
I+RL + D L+ LV EF +L + LD E + +YQ L +
Sbjct: 88 IIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVIHRLR--LDHETLSFLVYQSLCAIKH 145
Query: 117 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176
H+ +HRDLKP N+++N LK+ DFGLAR + +R S V T +YR P+V+ G
Sbjct: 146 LHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVDMR-MSDYVGTRYYRAPEVILGL 204
Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPD- 235
YS +D+WS GCI AE+ N LFPG D+ DQ +I +L TP + + +
Sbjct: 205 N-YSEKVDIWSVGCILAEMIN-HTVLFPGKDIRDQWTQISSVLRTPDDHFINQLEPIGAV 262
Query: 236 -YKPYPMYPATMSLVNVVPKLN--------------ATGRDLLQNLLKCNPVQRICADEA 280
+ P + A + +VP N RDLL N+LK NP +R ++A
Sbjct: 263 YVRSLPQHLA-RAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNMLKINPEERYSVEDA 321
Query: 281 LQHPYFAD 288
L HPY D
Sbjct: 322 LNHPYTMD 329
>ref|NP_492811.1| (NM_060410) casein kinase [Caenorhabditis elegans]
Length = 360
Score = 128 bits (322), Expect = 3e-30
Identities = 94/300 (31%), Positives = 153/300 (50%), Gaps = 31/300 (10%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62
Y+ + K+G G Y VF+ T E V +K ++ REI +L+ L+ N
Sbjct: 38 YQLVRKLGRGKYSEVFEGFKMSTDEKVVVKILK-----PVKKKKIKREIKILENLRGGTN 92
Query: 63 IVRLHDVLHSDKKLT--LVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHS 119
I+ L DV+ T L+FE + D K+ + + + D D ++ ++Y+LLK L FCHS
Sbjct: 93 IITLLDVVKDPISRTPALIFEHVNNSDFKQLYQTLS-DYD---IRYYLYELLKALDFCHS 148
Query: 120 RNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178
+ ++HRD+KP N++I+ EL+L D+GLA F P + Y+ V + +++ P++L +
Sbjct: 149 QGIMHRDVKPHNVMIDAEKRELRLIDWGLAE-FYHPRQDYNVRVASRYFKGPELLVDYQC 207
Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLP---- 234
Y S+DMWS GC+ A + P F G+D DQL RI ++LGT ++ A +
Sbjct: 208 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTDELYEYIARYHIDLDPR 267
Query: 235 --------DYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
K + + + V P+ D L LL+ + +R+ A EA+ H YF
Sbjct: 268 FNDILGRHSRKRWERFIHAENQHLVTPE----ALDFLDKLLRYDHAERLTAQEAMGHEYF 323
>ref|NP_010204.1| (NC_001136) putative protein kinase with similarity to mammalian
glycogen synthase kinase-3 and Drosophila
Zeste-White3/Shaggy; Mrk1p [Saccharomyces cerevisiae]
Length = 501
Score = 127 bits (319), Expect = 7e-30
Identities = 90/295 (30%), Positives = 151/295 (50%), Gaps = 23/295 (7%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y E +G G++G V +T++ VA+K+V D + RE+ +K L H N
Sbjct: 164 YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKN------RELETMKMLCHPNT 217
Query: 64 VRLHDVLHSDKK-----LTLVFEFCDQDLK---KYFDSCNGDLDPEIVKSFMYQLLKGLA 115
V L + + L LV ++ Q L ++F + + +K + YQL K L
Sbjct: 218 VGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALN 277
Query: 116 FCHS-RNVLHRDLKPQNLLINRNG-ELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173
+ H+ + HRD+KPQNLL++ K+ DFG A+ P + + + + +YR P+++
Sbjct: 278 YLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLK-PDQPNVSYICSRYYRAPELM 336
Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
FGA YS +D+WS+ C+ AEL G+PLF G DQL I +++G PT+++ M
Sbjct: 337 FGATNYSNQVDVWSSACVIAELL-LGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMN-- 393
Query: 234 PDYKPYPMYP--ATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
P+Y+ + ++P ++L + + DLL LK +P +R+ + L YF
Sbjct: 394 PNYEDH-VFPNIKPITLAEIFKAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSYF 447
>ref|NP_012229.1| (NC_001141) alpha subunit of casein kinase II; Cka1p [Saccharomyces
cerevisiae]
Length = 372
Score = 124 bits (310), Expect = 8e-29
Identities = 92/330 (27%), Positives = 162/330 (48%), Gaps = 51/330 (15%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALK--------------RVRLDDDDEGVPSSAL 49
YE K+G G Y VF+ D+ + +K ++ D +E VP + L
Sbjct: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99
Query: 50 ----------REICLLKELK----------HKNIVRLHDVLHS--DKKLTLVFEFCDQ-D 86
++ +LK ++ H NI+ L D++ K LVFE+ D D
Sbjct: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159
Query: 87 LKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLIN-RNGELKLADF 145
+ + DL+ ++ +M++LLK L +CHS ++HRD+KP N++I+ +N +L+L D+
Sbjct: 160 FRILYPKLT-DLE---IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215
Query: 146 GLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPG 205
GLA + + + Y+ V + +++ P++L ++Y S+D+WS G + A + P F G
Sbjct: 216 GLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274
Query: 206 NDVDDQLKRIFRLLGTPTEEQWPAMTKLP------DYKPYPMYPATMSLVNVVPKLNATG 259
DQL +I ++LGT E++ ++ D Y P + + L+
Sbjct: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334
Query: 260 R--DLLQNLLKCNPVQRICADEALQHPYFA 287
DL+ NLL+ + +R+ A EA+ HP+FA
Sbjct: 335 EIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364
>ref|NP_492689.1| (NM_060288) Helix-loop-helix DNA-binding domain, serine/threonine
kinase [Caenorhabditis elegans]
Length = 381
Score = 119 bits (299), Expect = 2e-27
Identities = 90/269 (33%), Positives = 132/269 (48%), Gaps = 44/269 (16%)
Query: 55 LKELKHKNIVRLHDVLHSDKK-------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFM 107
L +LKH+NIVRL L+S +K L L+FE+ +L ++ N +D VK +
Sbjct: 77 LGKLKHRNIVRL---LYSYQKQHEGRICLALIFEYIPLNLYQFLKDKNRRIDIVEVKLIV 133
Query: 108 YQLLKGLAFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLA--RAFGIPVRCYSAEVVT 164
+QL +G A ++ HRD+KPQNLL N G LK++DFG + ++ P + Y VT
Sbjct: 134 WQLFRGQAHLEKADICHRDIKPQNLLYNAETGLLKISDFGSSSIQSTKSPQQSYH---VT 190
Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224
+YRPP+++ G+K Y ID WS GC+F EL G + G ++Q + IF +LG PT+
Sbjct: 191 RYYRPPELILGSKYYGCKIDTWSCGCVFGELLKGG-IILAGKSSNNQAEVIFDMLGYPTD 249
Query: 225 EQWPAM----TKLP---DYKPYPMYPATMSLVNVVPKLNATGRD---------------- 261
+M TKL D Y T L + + +D
Sbjct: 250 SDVSSMKVSSTKLQEVLDSYEYNKSKTTADLTYLYTQTVIYQKDRRTTVYNTKIEQDDMK 309
Query: 262 ----LLQNLLKCNPVQRICADEALQHPYF 286
+L +L NP +R+ E L HPYF
Sbjct: 310 ESVAVLLQILVYNPNKRLSGIEILTHPYF 338
>ref|NP_492367.1| (NM_059966) serine/threonine kinase [Caenorhabditis elegans]
Length = 381
Score = 117 bits (294), Expect = 6e-27
Identities = 90/270 (33%), Positives = 131/270 (48%), Gaps = 46/270 (17%)
Query: 55 LKELKHKNIVRLHDVLHSDKK-------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFM 107
L +LKHKNIVRL L S +K L L+FE+ +L ++ N +D VK +
Sbjct: 77 LGKLKHKNIVRL---LFSYQKQHEGRICLGLIFEYIPMNLHQFLKDNNRRVDIIEVKLIV 133
Query: 108 YQLLKGLAFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGI--PVRCYSAEVVT 164
+QL +G A + HRD+KPQNLL N + G LK++D+G + + P + Y VT
Sbjct: 134 WQLFRGQAHLEKSEICHRDIKPQNLLYNADTGLLKISDYGSSAIESVKTPQQSYH---VT 190
Query: 165 LWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTE 224
+YRPP++L G+K Y ID WS GC+F EL G G +Q + +F + G PT
Sbjct: 191 RYYRPPELLLGSKNYGCKIDTWSCGCVFGELLKGG-IFLAGKSAKNQAEVVFDMFGVPTA 249
Query: 225 EQWPAM----TK----LPDYKPYPMYPATMSLVNVVPKLNATGRD--------------- 261
E +M TK + Y+P T L + + + RD
Sbjct: 250 EDVSSMNVSNTKYKEIIQSYEP-DTSKRTADLAYLYNQTASFQRDRRSTVYNTKIDYSDM 308
Query: 262 -----LLQNLLKCNPVQRICADEALQHPYF 286
LL+ +L NP +R+C E L +P+F
Sbjct: 309 KDSVELLRQVLVYNPSRRLCGIEFLTNPFF 338
>ref|NP_012440.1| (NC_001142) bypass requirement for protein kinase C homolog; Bck1p
[Saccharomyces cerevisiae]
Length = 1478
Score = 117 bits (294), Expect = 6e-27
Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 37/290 (12%)
Query: 6 KLEKIGEGTYGTVFKAKNRDTHEIVALKRVRL---DDDDEGVPSS--ALR-EICLLKELK 59
K E IG+G++G V+ N T E++A+K+V + +E + S+ ALR E+ LK+L
Sbjct: 1177 KGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLD 1236
Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHS 119
H NIV+ + + +L E+ G D ++K Q+LKGLA+ HS
Sbjct: 1237 HLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHS 1296
Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTL----WYRPPDVLFG 175
+ +LHRD+K NLL++++G K++DFG++R YS +T+ ++ P+++
Sbjct: 1297 KGILHRDMKADNLLLDQDGICKISDFGISRK---SKDIYSNSDMTMRGTVFWMAPEMVDT 1353
Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPD 235
+ YS +D+WS GCI E+ RP E AM K+
Sbjct: 1354 KQGYSAKVDIWSLGCIVLEMFAGKRP-------------------WSNLEVVAAMFKIGK 1394
Query: 236 YKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
K P P + +P ++ GR+ L + NP +R A+E L HP+
Sbjct: 1395 SKSAPPIPE-----DTLPLISQIGRNFLDACFEINPEKRPTANELLSHPF 1439
>ref|NP_496356.1| (NM_063955) serine/threonine kinase [Caenorhabditis elegans]
Length = 410
Score = 115 bits (289), Expect = 2e-26
Identities = 75/201 (37%), Positives = 114/201 (56%), Gaps = 7/201 (3%)
Query: 30 VALKRVRLDDDDEGVPSSALREICLLKELKH---KNIVRLHDVLHSDKKLT-LVFEFCDQ 85
VA+K V D + + +S EI +L +L H N++ + +DK + LV ++ Q
Sbjct: 54 VAVKNVWSDTETRHLATSEYPEIQILSKLFHPAISNLLYFYSRNANDKVINCLVLDYLPQ 113
Query: 86 DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRN-GELKLAD 144
DL + D D K + +QL ++ S+N++H D+KPQN++++R G LKLAD
Sbjct: 114 DLARLRDQ-GVKFDVLDAKLYTFQLFCAISHLTSKNIVHMDIKPQNVVMDRMAGRLKLAD 172
Query: 145 FGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP 204
FG AR + SA VT +YRPP++LFG + ++ SID+WSA C+ EL A R LF
Sbjct: 173 FGNARRLETNEKTGSAYQVTRFYRPPELLFGCEKFTASIDIWSATCVAFELF-ANRVLFK 231
Query: 205 GNDVDDQLKRIFRLLGTPTEE 225
G D DQ+ I + G PT++
Sbjct: 232 GKDTKDQIVLITGVFGYPTDD 252
>ref|NP_490967.1| (NM_058566) Y39G10AR.4.p [Caenorhabditis elegans]
Length = 579
Score = 115 bits (287), Expect = 4e-26
Identities = 65/234 (27%), Positives = 115/234 (48%), Gaps = 5/234 (2%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+YE++ +G+G +G+ + R+ +V +K + + D D AL E+ LL ++H N
Sbjct: 170 RYERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPN 229
Query: 63 IVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRN 121
I+ +D + L + E+ D L + LD E + M Q+ +A+ H +
Sbjct: 230 IIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQNLLDEEQIGDMMIQMCSAVAYLHENS 289
Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPPDVLFGAKLY 179
VLHRDLK N+ + R+ +K+ DFG+++ G A+ V T +Y P++ G Y
Sbjct: 290 VLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVS-Y 348
Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
+ DMW+ GCI E+ + F G+++ + I TP + + A K+
Sbjct: 349 NEKSDMWALGCILYEMC-CLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKM 401
>ref|NP_491474.1| (NM_059073) ser/thr-protein kinase [Caenorhabditis elegans]
Length = 440
Score = 113 bits (283), Expect = 1e-25
Identities = 85/292 (29%), Positives = 145/292 (49%), Gaps = 14/292 (4%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEI-VALKRVRLDDDDEGVPSSALREICLLKELK 59
M K E++ G + V+K R+ +E +A+K+ ++G + + + K
Sbjct: 20 MLKIEEVHLHSCGVFSNVYKGILREPYEKKIAIKK---SWPEKGERNFEFIFLTGRERAK 76
Query: 60 HKNIVRLHDVL-HS-DKKL--TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLA 115
HKN++ + HS D K+ + VF+F L + DLD ++ + +Q+ GL
Sbjct: 77 HKNVIHMIFAFSHSYDTKVCESYVFDFMPNTLAEVIRQKLTDLD---IRLYTWQIFSGLK 133
Query: 116 FCHSRNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174
+ V+HRDLKP N+L++ + LK++DFG A+ + + + VT +YRPP++L
Sbjct: 134 YLEEHKVVHRDLKPVNILVDHDTAFLKISDFGSAKII-VKGKANNFYQVTRFYRPPELLM 192
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLP 234
A Y++++D+WSAGCI AE+ +FPG D QLK R G P E+ AM
Sbjct: 193 KAMEYNSTVDVWSAGCIMAEMVKR-HVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEK 251
Query: 235 DYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
K Y + L +V ++ ++ +L P +R+ + LQ +F
Sbjct: 252 LEKEYWKFTKGFGLQRLVNDISPDQLQFIKRILVYAPEKRLRGKQLLQDDFF 303
>ref|NP_009411.1| (NC_001133) Required for mitosis and sporulation, cell division
cycle blocked at 36 degrees; Cdc15p [Saccharomyces
cerevisiae]
Length = 974
Score = 112 bits (281), Expect = 2e-25
Identities = 65/200 (32%), Positives = 108/200 (53%), Gaps = 7/200 (3%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y + IG G+YG V+KA N+ T ++VA+K V ++D+E + + EI LLK L H N
Sbjct: 24 QYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEE--LNDIMAEISLLKNLNHNN 81
Query: 63 IVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRN 121
IV+ H + +L ++ E+C + L++ + L K+++ Q L GL + H
Sbjct: 82 IVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEG 141
Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181
V+HRD+K N+L++ + +KLADFG++ + TL + P++L G + ST
Sbjct: 142 VIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAG---TLNWMAPEIL-GNRGAST 197
Query: 182 SIDMWSAGCIFAELANAGRP 201
D+WS G E+ P
Sbjct: 198 LSDIWSLGATVVEMLTKNPP 217
>ref|NP_492097.1| (NM_059696) serine/threonine kinase [Caenorhabditis elegans]
Length = 1016
Score = 111 bits (278), Expect = 4e-25
Identities = 64/211 (30%), Positives = 111/211 (52%), Gaps = 2/211 (0%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y+ + IG+G + V AK+ T E+VA+K + DE S ++E+ +K ++H NI
Sbjct: 27 YDLEKTIGQGHFAVVKLAKHVFTGEMVAVKIIDKTKMDEASTSQIMKEVRCMKLVQHANI 86
Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVL 123
VRL++VL + K+ L+ E D DL + + + + + Q++ + +CH +V+
Sbjct: 87 VRLYEVLDTQTKIFLILELGDYDLHDFIIKHEKGVCESLAQQYFCQIMTAIDYCHQLHVV 146
Query: 124 HRDLKPQNLL-INRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
HRDLKP+N++ + G +KL DFG + ++ P + +L Y P++L G + +
Sbjct: 147 HRDLKPENVVFFEKLGMVKLTDFGFSNSYE-PGEQLNTSCGSLAYSAPEILLGDSYDAPA 205
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLK 213
+D+WS G I L P ND + K
Sbjct: 206 VDVWSLGVILYMLVCGRLPFQEANDSETLTK 236
>ref|NP_501815.1| (NM_069414) serine/threonine kinase [Caenorhabditis elegans]
Length = 399
Score = 110 bits (274), Expect = 1e-24
Identities = 84/297 (28%), Positives = 144/297 (48%), Gaps = 14/297 (4%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEI-VALKRVRLDDDDEGVPSSALREICLLKELK 59
M K E++ G + V+K R+ HE +A+K+ ++G + + + K
Sbjct: 20 MLKIEEVHLHSCGVFSNVYKGILREPHEKNIAIKK---SWPEKGERNFEFIFLTGRERTK 76
Query: 60 HKNIVRLHDVL-HS-DKKL--TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLA 115
HKN++ + HS K+ + VF++ L + DLD ++ + +Q+ GL
Sbjct: 77 HKNVIHMIFAFSHSYGTKVCESYVFDYMPNTLAEVIRQKLTDLD---IRLYTWQIFSGLK 133
Query: 116 FCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 174
+ V+HRDLKP N+L++ + G LK++DFG + + + + VT +YRPP++L
Sbjct: 134 YLEEHRVVHRDLKPVNILVDHDTGFLKISDFGSVKII-VKGKANNHYQVTRFYRPPELLQ 192
Query: 175 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLP 234
A Y+ ++D+WSAGCI AE+ R +FPG D Q+K R G PTE+ AM
Sbjct: 193 KAMEYNCTVDVWSAGCIMAEMVKR-RVVFPGRDSAQQMKLYCRCFGVPTEQDILAMKGER 251
Query: 235 DYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADFCP 291
+ L +V ++ ++ +L P +R+ + LQ +F P
Sbjct: 252 LENELWKFTKGFGLQRLVTEITPDQLQFIKRILVYTPEKRLHGKQLLQDDFFQTKTP 308
>ref|NP_502493.1| (NM_070092) serine/threonine kinase (2 domains) [Caenorhabditis
elegans]
Length = 817
Score = 110 bits (274), Expect = 1e-24
Identities = 82/258 (31%), Positives = 124/258 (47%), Gaps = 20/258 (7%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK- 61
+YE L+ IG+G++G V KA + + VALK VR +++ A EI +L L+ +
Sbjct: 460 RYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVR---NEKRFHRQADEEIRILDHLRRQD 516
Query: 62 -----NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFMYQLLKGLA 115
NI+ + D + + FE +L + +V+ F Y +L L
Sbjct: 517 SDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLD 576
Query: 116 FCHSRNVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173
++H DLKP+N+L+ + G +K+ DFG + + Y + + +YR P+V+
Sbjct: 577 LLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTY---IQSRFYRAPEVI 633
Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
G K Y IDMWS GCI AEL G PL PG D +DQL I LLG P + +
Sbjct: 634 LGTK-YGMPIDMWSLGCILAELL-TGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRA 691
Query: 234 PDY---KPYPMYPATMSL 248
+ K YP Y S+
Sbjct: 692 RTFITSKGYPRYCTATSM 709
>ref|NP_502492.1| (NM_070091) F49E11.1c.p [Caenorhabditis elegans]
Length = 796
Score = 110 bits (274), Expect = 1e-24
Identities = 82/258 (31%), Positives = 124/258 (47%), Gaps = 20/258 (7%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK- 61
+YE L+ IG+G++G V KA + + VALK VR +++ A EI +L L+ +
Sbjct: 460 RYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVR---NEKRFHRQADEEIRILDHLRRQD 516
Query: 62 -----NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFMYQLLKGLA 115
NI+ + D + + FE +L + +V+ F Y +L L
Sbjct: 517 SDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLD 576
Query: 116 FCHSRNVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173
++H DLKP+N+L+ + G +K+ DFG + + Y + + +YR P+V+
Sbjct: 577 LLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTY---IQSRFYRAPEVI 633
Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
G K Y IDMWS GCI AEL G PL PG D +DQL I LLG P + +
Sbjct: 634 LGTK-YGMPIDMWSLGCILAELL-TGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRA 691
Query: 234 PDY---KPYPMYPATMSL 248
+ K YP Y S+
Sbjct: 692 RTFITSKGYPRYCTATSM 709
>ref|NP_502494.1| (NM_070093) serine/threonine kinase (2 domains) [Caenorhabditis
elegans]
Length = 508
Score = 110 bits (274), Expect = 1e-24
Identities = 82/258 (31%), Positives = 124/258 (47%), Gaps = 20/258 (7%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK- 61
+YE L+ IG+G++G V KA + + VALK VR +++ A EI +L L+ +
Sbjct: 166 RYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVR---NEKRFHRQADEEIRILDHLRRQD 222
Query: 62 -----NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFMYQLLKGLA 115
NI+ + D + + FE +L + +V+ F Y +L L
Sbjct: 223 SDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLD 282
Query: 116 FCHSRNVLHRDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 173
++H DLKP+N+L+ + G +K+ DFG + + Y + + +YR P+V+
Sbjct: 283 LLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTY---IQSRFYRAPEVI 339
Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
G K Y IDMWS GCI AEL G PL PG D +DQL I LLG P + +
Sbjct: 340 LGTK-YGMPIDMWSLGCILAELL-TGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRA 397
Query: 234 PDY---KPYPMYPATMSL 248
+ K YP Y S+
Sbjct: 398 RTFITSKGYPRYCTATSM 415
>ref|NP_009998.2| (NC_001135) functionally redundant with, and homologous to, SSK2;
Ssk22p [Saccharomyces cerevisiae]
Length = 1331
Score = 109 bits (272), Expect = 2e-24
Identities = 81/305 (26%), Positives = 141/305 (45%), Gaps = 50/305 (16%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSAL--REICLLKELKH 60
+++K IG GT+G V+ A N + EI+A+K +++ D L E+ +L+ L H
Sbjct: 1033 RWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNH 1092
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKS-FMYQLLKGLAFCH 118
NIV+ + V K+ + E+C+ L D +G ++ E+V + ++LL+GLA+ H
Sbjct: 1093 PNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLD--HGRIEDEMVTQVYTFELLEGLAYLH 1150
Query: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARA----------------FGIPVRCYSAEV 162
V+HRD+KP+N+L++ NG +K DFG AR FG+ + + +
Sbjct: 1151 QSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMM 1210
Query: 163 VTLWYRPPDVLFGAKLYST--SIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220
T Y P+ + G+ + + D+W+ GC+ E+A RP
Sbjct: 1211 GTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRP------------------W 1252
Query: 221 TPTEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEA 280
+ + +W M Y + + + ++ A GR L+ L +P R A E
Sbjct: 1253 SNLDNEWAIM--------YHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVEL 1304
Query: 281 LQHPY 285
L P+
Sbjct: 1305 LIDPW 1309
>ref|NP_014704.1| (NC_001147) may have a role in regulation and/or execution of the
eukaryotic cell cycle; Cka2p [Saccharomyces cerevisiae]
Length = 339
Score = 108 bits (271), Expect = 3e-24
Identities = 90/303 (29%), Positives = 147/303 (47%), Gaps = 32/303 (10%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAK---NRDTHEIVALKRVRLDDDDEGVPSSALREICLLKE 57
+ YE + KIG G Y VF + N I LK V++ RE+ +L
Sbjct: 47 ISNYEIINKIGRGKYSEVFSGRCIVNNQKCVIKVLKPVKM--------KKIYRELKILTN 98
Query: 58 LKH-KNIVRLHDVLH-SDKKL-TLVFEFCDQDLKKY-FDSCNGDLDPEIVKSFMYQLLKG 113
L N+V L+D++ +D K+ L+FE ++K F + ++ + QLL
Sbjct: 99 LTGGPNVVGLYDIVQDADSKIPALIFE----EIKNVDFRTLYPTFKLPDIQYYFTQLLIA 154
Query: 114 LAFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172
L +CHS ++HRD+KPQN++I+ +L+L D+GLA F P Y+ V + +++ P++
Sbjct: 155 LDYCHSMGIMHRDVKPQNVMIDPTERKLRLIDWGLAE-FYHPGVDYNVRVASRYHKGPEL 213
Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTK 232
L Y S+D+WS GC+ A + P F G+ DQL +I +LG T+E + K
Sbjct: 214 LVNLNQYDYSLDLWSVGCMLAAIVFKKEPFFKGSSNPDQLVKIATVLG--TKELLGYLGK 271
Query: 233 ----LPD-----YKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQH 283
LP + + T + + DL+ NLL+ + +R+ A EA+ H
Sbjct: 272 YGLHLPSEYDNIMRDFTKKSWTHFITSETKLAVPEVVDLIDNLLRYDHQERLTAKEAMDH 331
Query: 284 PYF 286
+F
Sbjct: 332 KFF 334
>ref|NP_012394.1| (NC_001142) Serine-threonine protein kinase; Yak1p [Saccharomyces
cerevisiae]
Length = 807
Score = 108 bits (271), Expect = 3e-24
Identities = 79/231 (34%), Positives = 121/231 (52%), Gaps = 18/231 (7%)
Query: 2 QKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61
+KY L+ +G+GT+G V K +N T EI+A+K V+ + + ++ E +L+ L K
Sbjct: 367 RKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRTE---YLTQSITEAKILELLNQK 423
Query: 62 -------NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFMYQLLKG 113
+ +R++D L LVFE +L + L +++++F Q+L
Sbjct: 424 IDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLSIQLIRTFTTQILDS 483
Query: 114 LAFCHSRNVLHRDLKPQNLLINR--NGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 171
L ++H DLKP+N+L+ ELK+ DFG + V Y + + +YR P+
Sbjct: 484 LCVLKESKLIHCDLKPENILLCAPDKPELKIIDFGSSCEEARTVYTY---IQSRFYRAPE 540
Query: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222
++ G YSTSIDMWS GCI AEL G P+FPG +QL RI LG P
Sbjct: 541 IILGIP-YSTSIDMWSLGCIVAELF-LGIPIFPGASEYNQLTRIIDTLGYP 589
>ref|NP_506499.1| (NM_074098) serine/threonine kinase (KIN1/SNF1/Nim1 subfamily)
[Caenorhabditis elegans]
Length = 1192
Score = 105 bits (263), Expect = 2e-23
Identities = 63/219 (28%), Positives = 115/219 (51%), Gaps = 10/219 (4%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
KY+ L+ IG+G + V AK+ T VA+K + + RE+ ++K+L H N
Sbjct: 169 KYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPN 228
Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
IV+L+ V+ +++ L LV E+ + +G + + ++ Q++ + + HS+N+
Sbjct: 229 IVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNI 288
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVR----CYSAEVVTLWYRPPDVLFGAKL 178
+HRDLK +NLL++++ +K+ADFG + F + + C S Y P++ G K
Sbjct: 289 IHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPP-----YAAPELFSGKKY 343
Query: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFR 217
+D+WS G I L + P F G ++ + +R+ R
Sbjct: 344 DGPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLR 381
>ref|NP_510080.1| (NM_077679) serine/threonine kinase [Caenorhabditis elegans]
Length = 294
Score = 105 bits (261), Expect = 4e-23
Identities = 66/202 (32%), Positives = 107/202 (52%), Gaps = 8/202 (3%)
Query: 8 EKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDD-DEGVPSSALREICLLKELKHKNIVRL 66
+KIG+G + VF+A+ VALK++++ + D+ L+EI LLK+L H N++R
Sbjct: 27 KKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRY 86
Query: 67 HDVLHSDKKLTLVFEFCDQD----LKKYFDSCNGDLDPE-IVKSFMYQLLKGLAFCHSRN 121
+ + +L +V E + + K+F G L PE + + QL + LA HS+
Sbjct: 87 YASFIDNNQLNIVLELAEAGDMSRMIKHFKK-GGRLIPEKTIWKYFVQLARALAHMHSKR 145
Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181
++HRD+KP N+ I NG +KL D GL R F + V T +Y P+ + + Y+
Sbjct: 146 IMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESG-YNF 204
Query: 182 SIDMWSAGCIFAELANAGRPLF 203
D+WS GC+ E+A P +
Sbjct: 205 KSDLWSTGCLLYEMAALQSPFY 226
>ref|NP_491714.1| (NM_059313) protein kinase [Caenorhabditis elegans]
Length = 305
Score = 105 bits (261), Expect = 4e-23
Identities = 66/200 (33%), Positives = 107/200 (53%), Gaps = 7/200 (3%)
Query: 10 IGEGTYGTVFKAKNRDTHEIVALKRV-RLDDDDEGVPSSALREICLLKELKHKNIVRLHD 68
+G+G +G+V+ A+ + H VA+K + + GV REI + L H NI++L+
Sbjct: 36 LGKGKFGSVYLARTKTGHFHVAIKVLFKSQLISGGVEHQLEREIEIQSHLNHPNIIKLYT 95
Query: 69 VLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDL 127
KK+ LV E+ ++ K +P K +MY++ L++CH +NV+HRD+
Sbjct: 96 YFWDAKKIYLVLEYAPGGEMYKQLTVSKRFSEPTAAK-YMYEIADALSYCHRKNVIHRDI 154
Query: 128 KPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWS 187
KP+NLLI GELK+ DFG + P T+ Y PP+++ GA +S ++D+W+
Sbjct: 155 KPENLLIGSQGELKIGDFGW--SVHAPSNKRQTMCGTMDYLPPEMVNGAD-HSDAVDLWA 211
Query: 188 AGCIFAELANAGRPLFPGND 207
G + E G+P F D
Sbjct: 212 IGVLCYEFL-VGKPPFEHED 230
>ref|NP_508718.1| (NM_076317) serine/threonine protein kinase [Caenorhabditis
elegans]
Length = 821
Score = 104 bits (259), Expect = 7e-23
Identities = 76/244 (31%), Positives = 125/244 (51%), Gaps = 23/244 (9%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALR---EICLLKELK 59
+YE LE +G+GT+G V KA + T EIVA+K ++ PS A + E+ +L L
Sbjct: 121 QYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKH------PSYARQGQIEVSILSRLS 174
Query: 60 HK-----NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN-GDLDPEIVKSFMYQLLKG 113
++ N VR + + LVFE +Q+L + L ++ ++Q+L
Sbjct: 175 NENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTA 234
Query: 114 LAFCHSRNVLHRDLKPQNLLI----NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRP 169
L S ++H DLKP+N+++ + +K+ DFG A V + + + +YR
Sbjct: 235 LLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVT--NTYLQSRYYRA 292
Query: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPA 229
P+++ G ++ SIDMWS GC+ AEL G PL+PG+ DQ++ I + G P +
Sbjct: 293 PEIILGLP-FNESIDMWSLGCVIAELF-LGWPLYPGSSEYDQIRFIIQTQGLPPTSMLES 350
Query: 230 MTKL 233
+KL
Sbjct: 351 ASKL 354
>ref|NP_509010.1| (NM_076609) Serine/threonine protein kinase [Caenorhabditis
elegans]
Length = 572
Score = 103 bits (257), Expect = 1e-22
Identities = 75/250 (30%), Positives = 117/250 (46%), Gaps = 27/250 (10%)
Query: 2 QKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 61
+KY K++KIG G G+V+ A T VA+K++ L D + + EI +++E KH
Sbjct: 293 RKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPK--KELIINEILVMRENKHA 350
Query: 62 NIVRLHDVLHSDKKLTLVFEF-CDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSR 120
NIV D +L +V E+ L C ++ I+ + ++L+ L F HSR
Sbjct: 351 NIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQ--MEDGIIAAVCREVLQALEFLHSR 408
Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
+V+HRD+K N+L+ +G +KL DFG R + V T ++ P+V+ K Y
Sbjct: 409 HVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVV-TRKQYG 467
Query: 181 TSIDMWSAGCIFAE-------------------LANAGRPLFPGNDVDDQLKRIF--RLL 219
+D+WS G + E +A G+P FPG D L + F L
Sbjct: 468 PKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSAL 527
Query: 220 GTPTEEQWPA 229
E +W A
Sbjct: 528 EVQVENRWSA 537
>ref|NP_010182.1| (NC_001136) DNA damage response; Dun1p [Saccharomyces cerevisiae]
Length = 513
Score = 102 bits (254), Expect = 3e-22
Identities = 97/321 (30%), Positives = 145/321 (44%), Gaps = 72/321 (22%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREIC-LLKELKHK 61
KY +++G G Y V +AKN+ T + VA+K +D+ + RE +L ++H
Sbjct: 199 KYLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQNDDQKKNKQFREETNILMRVQHP 258
Query: 62 NIVRLHD-----VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIV----------KSF 106
NIV L D + S + LV E D +G+L IV K+
Sbjct: 259 NIVNLLDSFVEPISKSQIQKYLVLEKID----------DGELFERIVRKTCLRQDESKAL 308
Query: 107 MYQLLKGLAFCHSRNVLHRDLKPQNLLINRNG-------------------ELKLADFGL 147
QLL GL + H +N++HRD+KP+N+L+N ++K+ADFGL
Sbjct: 309 FKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGL 368
Query: 148 ARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGND 207
A+ G ++ + T Y P+VL K Y++ +D+WSAG I + G P F
Sbjct: 369 AKFTG-EMQFTNTLCGTPSYVAPEVL-TKKGYTSKVDLWSAGVIL-YVCLCGFPPF---- 421
Query: 208 VDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLL 267
DQ LG P+ ++ K Y PY K++ + L+ NLL
Sbjct: 422 -SDQ-------LGPPSLKEQILQAKYAFYSPY------------WDKIDDSVLHLISNLL 461
Query: 268 KCNPVQRICADEALQHPYFAD 288
NP +R DEAL HP+F D
Sbjct: 462 VLNPDERYNIDEALNHPWFND 482
>ref|NP_503086.1| (NM_070685) C49C3.10b.p [Caenorhabditis elegans]
Length = 384
Score = 102 bits (253), Expect = 3e-22
Identities = 80/284 (28%), Positives = 131/284 (45%), Gaps = 28/284 (9%)
Query: 30 VALKRVRLDDD--DEGVPSSALREICLLKELKHKNIVRLHDVL---HSDKKLT---LVFE 81
V +K+V L D D A RE+ + ++ N+V+++ + K+T +V E
Sbjct: 46 VVIKKVMLPDSLHDRQPWRRAQRELNCMLNIEDDNVVKMYSTFTPAENPLKMTEFYIVRE 105
Query: 82 FCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELK 141
+ +K S + VKS + + +G+ + H+ + HRDLKP+N+L+N+ G++K
Sbjct: 106 YMHGTMKNLSASTFNEGGHRTVKSIFFDICRGVQYLHAMRISHRDLKPENILMNQEGDVK 165
Query: 142 LADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF-GAKLYSTSIDMWSAGCIFAELANAGR 200
L DFG + + +V +YR P+++ T++D+WS GCI AEL G
Sbjct: 166 LCDFGHSNK--EDPTSNTPYIVQRFYRAPEIICETTDNNKTNVDIWSLGCILAELL-TGH 222
Query: 201 PLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTK----------LPDYKP----YPMYPATM 246
LF G D DQ + + LG + M + L Y+ Y +P T+
Sbjct: 223 VLFRGKDHIDQFILMVQFLGNAGPSFYSQMNEHARNFLLRYNLDQYQAPINFYSRFPDTV 282
Query: 247 --SLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFAD 288
++ PK RDLL +L NP R+ L HPY +
Sbjct: 283 FQGVLQFEPKECDMSRDLLFRMLVINPDDRLNIQMVLSHPYLRE 326
>ref|NP_501185.1| (NM_068784) ser/thr protein kinase [Caenorhabditis elegans]
Length = 1542
Score = 101 bits (252), Expect = 4e-22
Identities = 77/287 (26%), Positives = 127/287 (43%), Gaps = 43/287 (14%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALR-EICLLKELKHK 61
++E +K+G GTYG V A + VA+K ++ + +R EI ++ L H
Sbjct: 74 RFEITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHP 133
Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSR 120
NI+++++V + K+ LV E+ +L Y C G L + Q+ + +CH
Sbjct: 134 NIIQIYEVFENKDKIILVMEYSSGGELYDYVSRC-GSLPEAEARRIFRQITSAVLYCHKH 192
Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGA 176
V HRDLK +N+L+++N K+ADFGL+ F + C S Y P+++ G
Sbjct: 193 RVAHRDLKLENILLDQNNNAKIADFGLSNYFADKNLLTTFCGSP-----LYASPEIINGT 247
Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDY 236
+D WS G + L P F G D + +++I R G E
Sbjct: 248 PYKGPEVDCWSLGILLYTLVYGSMP-FDGRDFNRMVRQIKR--GAYFE------------ 292
Query: 237 KPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQH 283
P P+T S+ L++N+L+ NP +R + H
Sbjct: 293 ---PETPSTASM-------------LIRNMLRVNPERRATIFDIASH 323
>ref|NP_509199.1| (NM_076798) CDC2/CDC28 subfamily of ser/thr protein kinases
[Caenorhabditis elegans]
Length = 450
Score = 101 bits (252), Expect = 4e-22
Identities = 91/321 (28%), Positives = 136/321 (42%), Gaps = 44/321 (13%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
+Y E + G Y VF+ ++ T + V +K + + L I L + N
Sbjct: 130 RYSIDEVLSSGYYAQVFRCTDKKTDKKVCIKLKNRNLSTTYEETIILLRIHQLNRQNNSN 189
Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
VR+ D H +V E DL Y L P + ++ GL F H +
Sbjct: 190 CVRMLDYDHFRGHHFIVLENYQTDLASYLCG-RSKLTPREYIPMIKSIVHGLKFLHQNKI 248
Query: 123 LHRDLKPQNLLIN--RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
+H DLKP N+L+N LKL DFGL+ + + + TL+Y+ P+V K+ S
Sbjct: 249 IHGDLKPANVLLNEWNRNNLKLTDFGLSTF--VNQGPFFRDYQTLYYKAPEVFCQGKV-S 305
Query: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE--------------- 225
ID+WS GC+ AE+ G PLF G++ DQ I G P+ +
Sbjct: 306 VEIDIWSLGCVAAEIVR-GTPLFVGDNYFDQFALIQEFFGKPSRKLFNTWGGIHQFYTEY 364
Query: 226 -------QW-------PAMTKLPDYK---PYPMYPATMSLVNVVPKLNATGRDLLQNLLK 268
+W M P YK P P T SLV+ +P N + L + L++
Sbjct: 365 FFPRHCFEWLNPFNGDRTMEIEPHYKLAHPSRKPPLTSSLVSKLPGGNQ--KFLARFLMR 422
Query: 269 C---NPVQRICADEALQHPYF 286
C +P +RI + L HP+F
Sbjct: 423 CFEWDPTERIKSSFILNHPFF 443
>ref|NP_492259.1| (NM_059858) serine/threonine kinase (2 domains) [Caenorhabditis
elegans]
Length = 301
Score = 101 bits (251), Expect = 6e-22
Identities = 72/233 (30%), Positives = 117/233 (49%), Gaps = 15/233 (6%)
Query: 59 KHKNIVRLHDVLHSDK-KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFC 117
+ +NIV + + + +L +VF+ + DL L P ++ +M L++GL F
Sbjct: 70 QRRNIVEMLKSFETPEIRLGMVFKRYETDLFGILGD-RQRLQPSTIQKYMKGLMEGLQFI 128
Query: 118 HSRNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYSAEVV---TLWYRPPDVL 173
H + +HRD+KP+NLLI+ GE + +ADFG V S +VV TL Y + +
Sbjct: 129 HRMDYIHRDIKPENLLID--GETICIADFGET------VLSTSDKVVKPGTLPYLTIEHI 180
Query: 174 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKL 233
G K + S+D+W+A C+ + G LF N + I LLG T+E WP M KL
Sbjct: 181 LGYKENTKSMDIWAAACVLGAMFQ-GSHLFSQNSNLQTIHAIRLLLGNHTKETWPEMDKL 239
Query: 234 PDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
P + + P + + + DL++ ++K +P +R+ A + L H YF
Sbjct: 240 PLMQSIELPPVGEKTFSKIENITKEAADLMEQMMKYDPTKRLMASQVLNHEYF 292
>ref|NP_012821.1| (NC_001143) Negative regulator of swe1 kinase (which regulates
cdc28); Hsl1p [Saccharomyces cerevisiae]
Length = 1518
Score = 101 bits (251), Expect = 6e-22
Identities = 70/242 (28%), Positives = 116/242 (47%), Gaps = 34/242 (14%)
Query: 45 PSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIV 103
P REI ++K + H N++ L +V + +L LV E+ D +L Y S G L
Sbjct: 158 PYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVS-KGKLPEREA 216
Query: 104 KSFMYQLLKGLAFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEV 162
+ Q+++G+++CHS N+ HRDLKP+NLL++ +N +K+ADFG+A A +P +
Sbjct: 217 IHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMA-ALELPNKLLKTSC 275
Query: 163 VTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222
+ Y P+++ G + D+WS G + L P DD +K++ L
Sbjct: 276 GSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPF-----NDDNIKKLL-LKVQS 329
Query: 223 TEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQ 282
+ Q P+ L++ RDL+ +L +P +RI E L+
Sbjct: 330 GKYQMPS------------------------NLSSEARDLISKILVIDPEKRITTQEILK 365
Query: 283 HP 284
HP
Sbjct: 366 HP 367
>ref|NP_492668.1| (NM_060267) serine/threonine kinase [Caenorhabditis elegans]
Length = 512
Score = 100 bits (250), Expect = 7e-22
Identities = 73/248 (29%), Positives = 120/248 (47%), Gaps = 24/248 (9%)
Query: 55 LKELKHKNIVRLHDVLH----SDKKLTLVFEFCD-----------QDLKKYFDSCNGDLD 99
L+ HKNIV++ S + L + FC+ Q++ K D+
Sbjct: 77 LRRKPHKNIVQMLFAFSRNTTSGEGLEMKHSFCESYVFGFMPYTLQNILKKTRLAEVDM- 135
Query: 100 PEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCY 158
K + +QL +G+ + + ++HRD+KP N+L++ + G LK+ADFG A+ +
Sbjct: 136 ----KLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVV-LRGSSS 190
Query: 159 SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL 218
++ VT +YRPP++L AK Y +D+WSAGC E+ G+ LFPG + LK I +
Sbjct: 191 TSYQVTRFYRPPELLLDAKEYYWMVDVWSAGCCVGEMMK-GKVLFPGASIKIMLKLIVQA 249
Query: 219 LGTPTEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICAD 278
+G P+ M K+ + L V+ N D L +L+ P +R+
Sbjct: 250 IGLPSARDLDYM-KVSSMIDQQSAVKVIGLKEVLGTENQEWADFLGAILRYRPRERLHGP 308
Query: 279 EALQHPYF 286
+ L HP+F
Sbjct: 309 KLLSHPFF 316
>ref|NP_491914.1| (NM_059513) ser/thr-protein kinase [Caenorhabditis elegans]
Length = 357
Score = 100 bits (250), Expect = 7e-22
Identities = 72/234 (30%), Positives = 116/234 (48%), Gaps = 15/234 (6%)
Query: 1 MQKYEKLEKIGEGTYGTVF--KAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKEL 58
M YEK+ +G G +G + + KN +H+ V +K + E +S E+ LLK++
Sbjct: 1 MDNYEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKV 60
Query: 59 KHKNIVRLHDVLHSDKKLTLVFEFCD--------QDLKKYFDSCNGDLDPE-IVKSFMYQ 109
+H I+ D D +L +V ++ + D + DS + PE V + Q
Sbjct: 61 QHPLIIGYIDSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQ 120
Query: 110 LLKGLAFCHSRNVLHRDLKPQNLLINRNGE-LKLADFGLARAFGIPVRCYSAEVVTLWYR 168
+L L H +N++HRDLKPQN+L+NR LKL+DFG+++ G S + T Y
Sbjct: 121 ILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELGTK-SAASTVIGTPNYL 179
Query: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222
P++ ++ Y+ DMWS GC+ EL R F G ++ + +I R P
Sbjct: 180 SPEIC-ESRPYNQKSDMWSLGCVLYELLQLER-AFDGENLPAIVMKITRSKQNP 231
>ref|NP_010765.1| (NC_001136) Required for release from glucose repression, invertase
expression and sporulation; Snf1p [Saccharomyces
cerevisiae]
Length = 633
Score = 100 bits (250), Expect = 7e-22
Identities = 76/292 (26%), Positives = 133/292 (45%), Gaps = 49/292 (16%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALK----RVRLDDDDEGVPSSALREICLLKELK 59
Y+ ++ +GEG++G V A + T + VALK +V D +G REI L+ L+
Sbjct: 55 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQG---RIEREISYLRLLR 111
Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHS 119
H +I++L+DV+ S ++ +V E+ +L Y + + + F Q++ + +CH
Sbjct: 112 HPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQ-RDKMSEQEARRFFQQIISAVEYCHR 170
Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFG 175
++HRDLKP+NLL++ + +K+ADFGL+ + C S Y P+V+ G
Sbjct: 171 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPN-----YAAPEVISG 225
Query: 176 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPD 235
+D+WS G I + P D+ + +F+ +
Sbjct: 226 KLYAGPEVDVWSCGVILYVMLCRRLPF-----DDESIPVLFKNISNG------------- 267
Query: 236 YKPYPMYPATMSLVNVVPKLNATG-RDLLQNLLKCNPVQRICADEALQHPYF 286
V +PK + G L++ +L NP+ RI E +Q +F
Sbjct: 268 -------------VYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWF 306
>ref|NP_508742.1| (NM_076341) C24A8.4b.p [Caenorhabditis elegans]
Length = 421
Score = 100 bits (249), Expect = 1e-21
Identities = 64/220 (29%), Positives = 118/220 (53%), Gaps = 10/220 (4%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
++ + K+GEG+YG+V KA +R++ ++A+K+V +D D + + ++EI ++++ K K +
Sbjct: 35 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEI----IKEISIMQQCKSKYV 90
Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
V+ + L +V E+C + + L + + + + LKGL + H
Sbjct: 91 VKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKK 150
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
+HRD+K N+L+N +G KLADFG+A + + + T ++ P+V+ Y T
Sbjct: 151 IHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIG-YDTK 209
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222
D+WS G E+A GRP P +D+ ++ IF + P
Sbjct: 210 ADIWSLGITAIEMAE-GRP--PYSDI-HPMRAIFMIPTKP 245
>ref|NP_508744.1| (NM_076343) protein kinase [Caenorhabditis elegans]
Length = 523
Score = 100 bits (249), Expect = 1e-21
Identities = 64/220 (29%), Positives = 118/220 (53%), Gaps = 10/220 (4%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
++ + K+GEG+YG+V KA +R++ ++A+K+V +D D + + ++EI ++++ K K +
Sbjct: 63 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEI----IKEISIMQQCKSKYV 118
Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
V+ + L +V E+C + + L + + + + LKGL + H
Sbjct: 119 VKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKK 178
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
+HRD+K N+L+N +G KLADFG+A + + + T ++ P+V+ Y T
Sbjct: 179 IHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIG-YDTK 237
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222
D+WS G E+A GRP P +D+ ++ IF + P
Sbjct: 238 ADIWSLGITAIEMAE-GRP--PYSDI-HPMRAIFMIPTKP 273
>ref|NP_508743.1| (NM_076342) F14H12.4b.p [Caenorhabditis elegans]
Length = 525
Score = 100 bits (249), Expect = 1e-21
Identities = 64/220 (29%), Positives = 118/220 (53%), Gaps = 10/220 (4%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
++ + K+GEG+YG+V KA +R++ ++A+K+V +D D + + ++EI ++++ K K +
Sbjct: 63 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEI----IKEISIMQQCKSKYV 118
Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
V+ + L +V E+C + + L + + + + LKGL + H
Sbjct: 119 VKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKK 178
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
+HRD+K N+L+N +G KLADFG+A + + + T ++ P+V+ Y T
Sbjct: 179 IHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIG-YDTK 237
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222
D+WS G E+A GRP P +D+ ++ IF + P
Sbjct: 238 ADIWSLGITAIEMAE-GRP--PYSDI-HPMRAIFMIPTKP 273
>ref|NP_508741.1| (NM_076340) G-protein coupled receptor [Caenorhabditis elegans]
Length = 640
Score = 100 bits (249), Expect = 1e-21
Identities = 64/220 (29%), Positives = 118/220 (53%), Gaps = 10/220 (4%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
++ + K+GEG+YG+V KA +R++ ++A+K+V +D D + + ++EI ++++ K K +
Sbjct: 35 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDLQEI----IKEISIMQQCKSKYV 90
Query: 64 VRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNV 122
V+ + L +V E+C + + L + + + + LKGL + H
Sbjct: 91 VKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKK 150
Query: 123 LHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTS 182
+HRD+K N+L+N +G KLADFG+A + + + T ++ P+V+ Y T
Sbjct: 151 IHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIG-YDTK 209
Query: 183 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP 222
D+WS G E+A GRP P +D+ ++ IF + P
Sbjct: 210 ADIWSLGITAIEMAE-GRP--PYSDI-HPMRAIFMIPTKP 245
>ref|NP_510253.1| (NM_077852) serine/threonine kinase (KIN1/SNF1/Nim1 subfamily)
[Caenorhabditis elegans]
Length = 914
Score = 100 bits (248), Expect = 1e-21
Identities = 76/281 (27%), Positives = 126/281 (44%), Gaps = 32/281 (11%)
Query: 6 KLEK-IGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIV 64
KLEK +G+G G V + T VA+K V + E V REI ++K ++H +++
Sbjct: 48 KLEKTLGKGQTGLVKTGTHCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIEHPHVL 107
Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLH 124
L+DV + K L L+ E + G L + + F Q++ L FCH+ N+ H
Sbjct: 108 HLYDVYENKKYLYLLLEHVSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICH 167
Query: 125 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSID 184
RDLKP+NLL++ +K+ADFG+A + + + Y P+V+ G K D
Sbjct: 168 RDLKPENLLLDERNNIKVADFGMA-SLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKAD 226
Query: 185 MWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPYPMYPA 244
+WS G I L P DD L+ + E+ + +P + P
Sbjct: 227 VWSCGVILYALLVGALPF-----DDDNLRNLL-------EKVKRGVFHIPHFVP------ 268
Query: 245 TMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
A + LL+ +++ +P +R + +HP+
Sbjct: 269 ------------ADVQSLLRAMIEVDPGKRYSLADVFKHPW 297
>ref|NP_014513.1| (NC_001147) Hypothetical ORF; Yol128cp [Saccharomyces cerevisiae]
Length = 375
Score = 99.8 bits (247), Expect = 2e-21
Identities = 85/300 (28%), Positives = 141/300 (46%), Gaps = 36/300 (12%)
Query: 8 EKIGEGTYGTV----FKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
++IG G++GTV + + + A+KRV P E+ +L+ ++H N+
Sbjct: 45 KRIGHGSFGTVTQSILSSNSIEWLGPYAIKRVVKS------PKVQSLELEILQNIRHPNL 98
Query: 64 VRLHDVLHSD---------KKLTLVFEFCDQDLK----KYFDSCNGDLDP-EIVKSFMYQ 109
V L S + V E+ Q L +YFD NG P + +K + +Q
Sbjct: 99 VTLEFFFESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFD--NGSKMPTKHIKLYTFQ 156
Query: 110 LLKGLAFCHSRNVLHRDLKPQNLLI-NRNGELKLADFGLARAF--GIPVRCYSAEVVTLW 166
+L+ L HS ++ H DLKP N+LI +G K+ DFG A+ ++ Y + +
Sbjct: 157 ILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTYFC---SRF 213
Query: 167 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 226
YR P++L +K Y+T ID+WS GCI E+ G+PLF G+ + QL+ I +LLG +
Sbjct: 214 YRAPELLLNSKDYTTQIDIWSLGCIIGEMIK-GQPLFKGDSANSQLEEIAKLLGRFPKSS 272
Query: 227 WPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYF 286
+L D + M + P + + L +L + +R A + + H +F
Sbjct: 273 IKNSQELQDSLNDQKFKKFM---HWFPSIEFFDVEFLLKVLTYDATERCDARQLMAHEFF 329
>ref|NP_014092.1| (NC_001146) Disp. for mitosis, required for chr. segregation,
benomyl resist., basal IME1 transcript. in mitosis, IME1
induction in meiosis & ascus mat. independ. of IME1;
maybe in mitotic chr. segregation specific to CDEIII;
Mck1p [Saccharomyces cerev>
Length = 375
Score = 99.4 bits (246), Expect = 2e-21
Identities = 79/303 (26%), Positives = 138/303 (45%), Gaps = 32/303 (10%)
Query: 5 EKLEKIGEGTYGTVFKA----KNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
++ KIG G +GTV +A ++ A+K+V + + RE+ +L+ H
Sbjct: 36 KEYRKIGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKS------RELQILRIADH 89
Query: 61 KNIVRLH----------DVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQL 110
NIV+L + ++ + + E ++ +Y + ++ + ++ + YQ+
Sbjct: 90 PNIVKLQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTN-KLEMPLKHIRLYTYQI 148
Query: 111 LKGLAFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAF--GIPVRCYSAEVVTLWY 167
+G+ + H V HRD+KP N+L++ G LK+ DFG A+ P Y + + +Y
Sbjct: 149 ARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISY---ICSRFY 205
Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE-- 225
R P+++ G Y+T ID+W GC+ E+ G+ +F G + QL+ I +LLG P +
Sbjct: 206 RAPELIIGCTQYTTQIDIWGLGCVMGEML-IGKAIFQGQEPLLQLREIAKLLGPPDKRFI 264
Query: 226 --QWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQH 283
PA KP + G DLL +L P QR+ L H
Sbjct: 265 FFSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAH 324
Query: 284 PYF 286
+F
Sbjct: 325 QFF 327
>ref|NP_011970.1| (NC_001140) Kinase that interacts with Cdc31p; N-rich kinase 1;
Kic1p [Saccharomyces cerevisiae]
Length = 1080
Score = 99.4 bits (246), Expect = 2e-21
Identities = 64/200 (32%), Positives = 93/200 (46%), Gaps = 5/200 (2%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62
+++ E IG G +G V+K N T + A+K + LD D + V REI L LK N
Sbjct: 23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEV-EDVQREIQFLASLKQISN 81
Query: 63 IVRLHDVLHSDKKLTLVFEFC-DQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRN 121
I R + D L ++ E C L+ G +D + + M +LL L H N
Sbjct: 82 ITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP--GKIDEKYIGVIMRELLVALKCIHKDN 139
Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST 181
V+HRD+K N+LI G +KL DFG+A T ++ P+V+ Y T
Sbjct: 140 VIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDT 199
Query: 182 SIDMWSAGCIFAELANAGRP 201
+D+WS G E+A P
Sbjct: 200 KVDIWSLGITTYEIATGNPP 219
>ref|NP_502274.1| (NM_069873) Fibronectin type III domain (31 domains), IG
(immunoglobulin) superfamily (18 domains),
calcium/calmodulin dependent protein kinase
[Caenorhabditis elegans]
Length = 7160
Score = 99.0 bits (245), Expect = 3e-21
Identities = 80/289 (27%), Positives = 132/289 (44%), Gaps = 35/289 (12%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
+ Y+ E++G G +G V + R T A K V + + + +EI + L+H
Sbjct: 6260 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD--KETVRKEIQTMSVLRH 6317
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCH 118
+V LHD D ++ +++EF + +K D N + E V+ +M Q+ KGL H
Sbjct: 6318 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVE-YMRQVCKGLCHMH 6376
Query: 119 SRNVLHRDLKPQNLLI--NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176
N +H DLKP+N++ R+ ELKL DFGL A P + T + P+V G
Sbjct: 6377 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEG- 6434
Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDY 236
K DMWS G + + + +G F G + D+ L+ + K D+
Sbjct: 6435 KPVGYYTDMWSVG-VLSYILLSGLSPFGGENDDETLRNV----------------KSCDW 6477
Query: 237 KPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
M + S ++ G+D ++ LL +P R+ +AL+HP+
Sbjct: 6478 N---MDDSAFS------GISEDGKDFIRKLLLADPNTRMTIHQALEHPW 6517
>ref|NP_504721.1| (NM_072320) serine/threonine kinase [Caenorhabditis elegans]
Length = 829
Score = 99.0 bits (245), Expect = 3e-21
Identities = 59/202 (29%), Positives = 101/202 (49%), Gaps = 4/202 (1%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
YE L+++G GTYG V+KA++ + + A+K V+L+ D +EI +++E H NI
Sbjct: 15 YELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQ--QEIMVIRECSHPNI 72
Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVL 123
+ +L +V E+C + G L + + L+GL + H+ +
Sbjct: 73 IAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKI 132
Query: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL--YST 181
HRD+K N+L++ +G++KLADFG+A + + + T ++ P+V K Y
Sbjct: 133 HRDIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGM 192
Query: 182 SIDMWSAGCIFAELANAGRPLF 203
D+W+ G EL PLF
Sbjct: 193 QCDVWATGITAIELGECQPPLF 214
>ref|NP_502273.1| (NM_069872) Fibronectin type III domain (31 domains), IG
(immunoglobulin) superfamily (18 domains),
calcium/calmodulin dependent protein kinase
[Caenorhabditis elegans]
Length = 6831
Score = 99.0 bits (245), Expect = 3e-21
Identities = 80/289 (27%), Positives = 132/289 (44%), Gaps = 35/289 (12%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
+ Y+ E++G G +G V + R T A K V + + + +EI + L+H
Sbjct: 5931 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD--KETVRKEIQTMSVLRH 5988
Query: 61 KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCH 118
+V LHD D ++ +++EF + +K D N + E V+ +M Q+ KGL H
Sbjct: 5989 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVE-YMRQVCKGLCHMH 6047
Query: 119 SRNVLHRDLKPQNLLI--NRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 176
N +H DLKP+N++ R+ ELKL DFGL A P + T + P+V G
Sbjct: 6048 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAEG- 6105
Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDY 236
K DMWS G + + + +G F G + D+ L+ + K D+
Sbjct: 6106 KPVGYYTDMWSVG-VLSYILLSGLSPFGGENDDETLRNV----------------KSCDW 6148
Query: 237 KPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
M + S ++ G+D ++ LL +P R+ +AL+HP+
Sbjct: 6149 N---MDDSAFS------GISEDGKDFIRKLLLADPNTRMTIHQALEHPW 6188
>ref|NP_502989.1| (NM_070588) Y43D4A.6.p [Caenorhabditis elegans]
Length = 328
Score = 97.4 bits (241), Expect = 8e-21
Identities = 62/203 (30%), Positives = 105/203 (51%), Gaps = 5/203 (2%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEI-VALKRVRLDDDDEGVPSSALREICLLKELKHK 61
+++ ++ IG+G +G VF A+ + I VA+K++ + + +E + K +KHK
Sbjct: 5 QFKPIKSIGKGAFGQVFLAEKLNNPRIKVAMKKINIFGAPKEFLEQIQQEYYIQKNMKHK 64
Query: 62 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSR 120
NIV+++ + + L EF DL + D NG + VK ++ QL+ GL + H
Sbjct: 65 NIVKMYGMSMDTEFCYLFQEFVTGGDLFEKIDFENG-MPVNQVKGYLKQLMSGLKYIHGC 123
Query: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR--CYSAEVVTLWYRPPDVLFGAKL 178
++HRD+KP NLLIN + LK+ADFGL+ F + + + T + P++ K
Sbjct: 124 GIVHRDIKPDNLLINSSDALKIADFGLSTRFIVDDKEILLHERIGTTPFMAPELFAKKKH 183
Query: 179 YSTSIDMWSAGCIFAELANAGRP 201
+D+WSAG + L P
Sbjct: 184 RGPPVDIWSAGILVFSLLTGNLP 206
>ref|NP_015115.1| (NC_001148) Regulation of yeast chromosome segregation; Ipl1p
[Saccharomyces cerevisiae]
Length = 367
Score = 97.4 bits (241), Expect = 8e-21
Identities = 71/286 (24%), Positives = 128/286 (43%), Gaps = 33/286 (11%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDE-GVPSSALREICLLKELK 59
+ +E +K+G+G +G V+ ++R T I ALK + ++ + + RE+ + L
Sbjct: 101 LDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLN 160
Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHS 119
H N+ + + H +K++ L+ E+ +G + + ++YQ+ L + H
Sbjct: 161 HPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYMHK 220
Query: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179
+N++HRD+KP+N+LI N +KL DFG + P T+ Y P+++ ++ Y
Sbjct: 221 KNIIHRDIKPENILIGFNNVIKLTDFGWS-IINPPENRRKTVCGTIDYLSPEMV-ESREY 278
Query: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDYKPY 239
+ID W+ G + EL G P F D KRI L K+P
Sbjct: 279 DHTIDAWALGVLAFELL-TGAPPFEEEMKDTTYKRIAAL-----------DIKMPS---- 322
Query: 240 PMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
++ +DL+ LLK +P R+ + HP+
Sbjct: 323 --------------NISQDAQDLILKLLKYDPKDRMRLGDVKMHPW 354
>ref|NP_503161.1| (NM_070760) protein kinase [Caenorhabditis elegans]
Length = 637
Score = 96.7 bits (239), Expect = 1e-20
Identities = 63/206 (30%), Positives = 102/206 (48%), Gaps = 10/206 (4%)
Query: 4 YEKLEKIGEGTYG-TVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKEL---K 59
YE +E +GEG++ V AK +++ A+K + + DE S RE + K L +
Sbjct: 18 YEFIENLGEGSFAEVVLVAKVGTPNKMFAMKEISIVGKDECFMESIKRECSIQKRLSKSR 77
Query: 60 HKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN--GDLDPEIVKSFMYQLLKGLAFC 117
H N++ L ++ + + L+ + D F+ N G L + + QL+ GL F
Sbjct: 78 HLNMIHLFEIRTNPENYQLILSYADGG--DLFEKINQHGGLGSDEAHRYFKQLIDGLRFI 135
Query: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLA--RAFGIPVRCYSAEVVTLWYRPPDVLFG 175
H V HRD+KP+NLL+ ++G LK+ADFG A F + +A + Y P+VL G
Sbjct: 136 HEEGVTHRDIKPENLLLTKSGILKIADFGFATMHRFNGAEQMLNAYCGSPPYIAPEVLTG 195
Query: 176 AKLYSTSIDMWSAGCIFAELANAGRP 201
++D+WSAG + + P
Sbjct: 196 IDYRGPAVDIWSAGVVLIAMIAGAVP 221
Score = 75.5 bits (184), Expect = 3e-14
Identities = 75/308 (24%), Positives = 131/308 (42%), Gaps = 59/308 (19%)
Query: 2 QKYEKLEKIGEGTYGTVFKAK-NRDTHEIVALKRVRLDDDDEGVPSSALREICL---LKE 57
++Y+ +E + +G++G V + R+ VA+K V + ++ +E + L +
Sbjct: 341 KEYKVVEHLCKGSFGQVHLCELTRNPSVKVAVKEVAVSGKSRKNLTAVQKEYKIHRRLSK 400
Query: 58 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVK----------SFM 107
+ H+N++++ ++ + K +LV E+ D GDL E+ + S+
Sbjct: 401 IGHENVIQMMKMIETPKFYSLVMEYAD----------GGDLFDELKEQEKFSRKDAHSYF 450
Query: 108 YQLLKGLAFCHSRNVLHRDLKPQNLLI------NRNGELKLADFGLA---RAFGIPVRCY 158
QL+KGL F H + ++HRD+K +NLL+ + G LK+ DFGLA R G +
Sbjct: 451 KQLIKGLKFIHEQGIVHRDIKLENLLLVYSESEDDPGTLKITDFGLATKYRKDGEEI-ML 509
Query: 159 SAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL 218
S + + Y P+V G +D+WSAG + + L
Sbjct: 510 SEDCGSKPYAAPEVCTGNDYRGPPVDIWSAGVVLMTM----------------------L 547
Query: 219 LGTPTEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICAD 278
+G E W K D A N+ ++ LL+ LL NP +R
Sbjct: 548 VG---EHSWKVANKEKDAAYSNWINAKDEKANLWNVISGPTTALLRKLLHANPEKRATMA 604
Query: 279 EALQHPYF 286
+ P+F
Sbjct: 605 KIEADPWF 612
>ref|NP_015175.1| (NC_001148) Hypothetical ORF; Ypl150wp [Saccharomyces cerevisiae]
Length = 901
Score = 96.7 bits (239), Expect = 1e-20
Identities = 77/293 (26%), Positives = 131/293 (44%), Gaps = 50/293 (17%)
Query: 4 YEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Y+ L++IGEG++G V+ A +R TH V LK D +D + +RE+ ++ I
Sbjct: 41 YKILKQIGEGSFGKVYLALHRPTHRKVCLKTS--DKNDPNI----VREVFYHRQFDFPYI 94
Query: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVK--SFMYQLLKGLAFCHSRN 121
+L++V+ ++ K+ + E+C K+ +D +++ Q+ + + HS +
Sbjct: 95 TKLYEVIVTESKVWMALEYCPG--KELYDHLLSLRRISLLECGELFAQISGAVYYAHSMH 152
Query: 122 VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV-----TLWYRPPDVLFGA 176
+HRDLK +N+L+++NG KL DFG R C + + T Y P+++
Sbjct: 153 CVHRDLKLENILLDKNGNAKLTDFGFTR------ECMTKTTLETVCGTTVYMAPELIERR 206
Query: 177 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTKLPDY 236
ID+WS G I L P D DD+ K +W + + P Y
Sbjct: 207 TYDGFKIDIWSLGVILYTLITGYLPF----DDDDEAK-----------TKWKIVNEEPKY 251
Query: 237 KPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFADF 289
V+P RDL+ LL NP +R + L+HP+ +
Sbjct: 252 D-----------AKVIPD---DARDLISRLLAKNPGERPSLSQVLRHPFLQPY 290
>ref|NP_496002.1| (NM_063601) serine/threonine kinase [Caenorhabditis elegans]
Length = 381
Score = 96.3 bits (238), Expect = 2e-20
Identities = 76/267 (28%), Positives = 121/267 (44%), Gaps = 32/267 (11%)
Query: 48 ALREICLLKELKHKNIVRLHDV------LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPE 101
A RE+ ++ +N V+++ + + ++ V E+ D +L+ + S LD +
Sbjct: 63 AQRELFCTLHIQEENFVKMYSIYTWVETVEEMREFYTVREYMDWNLRNFILSTPEKLDHK 122
Query: 102 IVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAE 161
++KS + + + + HS V HRDLKP+N+LIN K++ F A V +
Sbjct: 123 VIKSIFFDVCLAVQYMHSIRVGHRDLKPENVLINYEAIAKISGFAHANREDPFVN--TPY 180
Query: 162 VVTLWYRPPDVLFGA-KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLG 220
+V +YR P++L S+D+WS GCI AEL G+ LF G DQ +I R LG
Sbjct: 181 IVQRFYRAPEILCETMDNNKPSVDIWSLGCILAELL-TGKILFTGQTQIDQFFQIVRFLG 239
Query: 221 TP-------------------TEEQWPAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRD 261
P Q+ T + ++ P ++ TM + L RD
Sbjct: 240 NPDLSFYMQMPDSARTFFLGLPMNQYQKPTNIHEHFPNSLFLDTMISEPIDCDL---ARD 296
Query: 262 LLQNLLKCNPVQRICADEALQHPYFAD 288
LL +L NP RI + L HPY +
Sbjct: 297 LLFRMLVINPDDRIDIQKILVHPYLEE 323
>ref|NP_010795.1| (NC_001136) Growth inhibitory gene; Gin4p [Saccharomyces
cerevisiae]
Length = 1142
Score = 96.3 bits (238), Expect = 2e-20
Identities = 74/292 (25%), Positives = 127/292 (43%), Gaps = 42/292 (14%)
Query: 8 EKIGEGTYGTVFKAKNRDTHEIVALKRVRL---------------DDDDEGVPSSALREI 52
E +G G+ G V A+N T + A+K + + +P REI
Sbjct: 23 ETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREI 82
Query: 53 CLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLK 112
++K L H N++RL+DV ++ L LV E+ ++ G L F Q++
Sbjct: 83 IIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIII 142
Query: 113 GLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDV 172
G+++CH+ ++HRDLKP+NLL++ +K+ADFG+A A + + Y P++
Sbjct: 143 GVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMA-ALETEGKLLETSCGSPHYAAPEI 201
Query: 173 LFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAMTK 232
+ G + D+WS G I L P D +D R L E + P+
Sbjct: 202 VSGIPYQGFASDVWSCGVILFALLTGRLPF----DEEDGNIRTLLLKVQKGEFEMPS--- 254
Query: 233 LPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHP 284
+++ +DL++ +L +P +RI + L+HP
Sbjct: 255 -------------------DDEISREAQDLIRKILTVDPERRIKTRDILKHP 287
>ref|NP_009584.1| (NC_001134) Hypothetical ORF; Ybr028cp [Saccharomyces cerevisiae]
Length = 525
Score = 96.3 bits (238), Expect = 2e-20
Identities = 66/244 (27%), Positives = 117/244 (47%), Gaps = 39/244 (15%)
Query: 1 MQKYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRL----------------------- 37
+ ++ + +G+G YG V K+ +T ++ A+K++R
Sbjct: 125 LHDFKPVRVLGQGAYGKVLLVKDVNTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGN 184
Query: 38 -DDDDEGVPSSALR---EICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDS 93
+D+D+G+ R E +L E++H NIV+L H + KL L+ ++ Y
Sbjct: 185 NNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLK 244
Query: 94 CNGDLDPEIVKSFMYQLLKGLAFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI 153
+G LD V + ++ L F H++ V++RDLKP+N L+N+ G L L DFGL++
Sbjct: 245 EHGTLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSAN 304
Query: 154 P----------VRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLF 203
V + + T Y P++L G K YS + D +S GC+ ++ G+P +
Sbjct: 305 DSAVDEEDPENVNALYSIIGTPEYCAPEILLG-KAYSQNCDWYSLGCLLYDML-VGKPPY 362
Query: 204 PGND 207
G++
Sbjct: 363 TGSN 366
>ref|NP_015172.1| (NC_001148) Required for DNA damage-induced checkpoint arest in G1,
S/M, and G2/M in mitosis, dispensable for sporulation
but required for wild-type spore viability; Mec1p and
Tel1p regulate rad53p phosphorylation; Rad53p
[Saccharomyces cerevisiae]
Length = 821
Score = 95.9 bits (237), Expect = 2e-20
Identities = 80/295 (27%), Positives = 135/295 (45%), Gaps = 48/295 (16%)
Query: 8 EKIGEGTYGTVFKAKNRDTHEIVALKRV---RLDDDDEGVPSSALREICLLKELKHKNIV 64
E +G+G + TV KA R T + A+K + ++ + +GV RE+ +L++L H IV
Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT----RELEVLQKLNHPRIV 257
Query: 65 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFMYQLLKGLAFCHSRNVLH 124
RL + +V EF F + +G + + + Q+L + + HS + H
Sbjct: 258 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISH 317
Query: 125 RDLKPQNLLINRNGE--LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL---- 178
RDLKP N+LI ++ +K+ DFGLA+ G TL Y P+V+ G
Sbjct: 318 RDLKPDNILIEQDDPVLVKITDFGLAKVQG-NGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376
Query: 179 --------YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPAM 230
YS+ +DMWS GC+ + P F G+ D ++++ +G + + P
Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLP-FSGSTQD----QLYKQIGRGSYHEGP-- 429
Query: 231 TKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPY 285
L D+ +++ RD + +LL+ +P R A +AL HP+
Sbjct: 430 --LKDF-----------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPW 465
>ref|NP_504582.1| (NM_072181) titin [Caenorhabditis elegans]
Length = 2783
Score = 94.4 bits (233), Expect = 7e-20
Identities = 79/304 (25%), Positives = 136/304 (43%), Gaps = 57/304 (18%)
Query: 3 KYEKLEKIGEGTYGTVFKAKNRDTHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 62
KY E++G+G YGTV++A + T + A K V++ + + + EI ++ +L H+
Sbjct: 194 KYIIHEELGKGAYGTVYRATEKATGKTWAAKMVQVRPGVK--KENVIHEISMMNQLHHEK 251
Query: 63 IVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGD---LDPEIVKSFMYQLLKGLAFCHS 119
++ LH+ ++ L+ EF + F+ D + E V+ +M+Q+L G++ H
Sbjct: 252 LLNLHEAFDMGNEMWLIEEFVSGG--ELFEKILEDDSLMSEEEVRDYMHQILLGVSHMHK 309
Query: 120 RNVLHRDLKPQNLLI--NRNGELKLADFGLAR----------AFGIPVRCYSAEVVTLWY 167
++H DLKP+N+L+ + ELK+ DFGLAR FG P C + EVV Y
Sbjct: 310 NQIVHLDLKPENILLKAKNSNELKIIDFGLARKLDPKKSVKLLFGTPEFC-APEVVN--Y 366
Query: 168 RPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQW 227
+P S DMW+ G I L + P F G+ +D L + + W
Sbjct: 367 QP---------VGLSTDMWTVGVISYVLLSGLSP-FLGDSDEDTLANVSASDWDFDDPSW 416
Query: 228 PAMTKLPDYKPYPMYPATMSLVNVVPKLNATGRDLLQNLLKCNPVQRICADEALQHPYFA 287
++ L +D + L+ + +R+ +AL+HP+
Sbjct: 417 DDVSDL-------------------------AKDFICRLMIKDKRKRMSVQDALRHPWIT 451
Query: 288 DFCP 291
P
Sbjct: 452 KMQP 455
Database: Completed Saccharomyces cerevisiae
Posted date: Mar 6, 2002 1:29 AM
Number of letters in database: 2,967,424
Number of sequences in database: 6306
Lambda K H
0.323 0.141 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,532,351
Number of Sequences: 26512
Number of extensions: 343615
Number of successful extensions: 2203
Number of sequences better than 10.0: 555
Number of HSP's better than 10.0 without gapping: 463
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 834
Number of HSP's gapped (non-prelim): 662
length of query: 292
length of database: 11,834,680
effective HSP length: 99
effective length of query: 193
effective length of database: 9,209,992
effective search space: 1777528456
effective search space used: 1777528456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 60 (27.7 bits)
