Your ClustalW Results:
Pairwise Scores:
CLUSTAL W (1.81) Multiple Sequence Alignments
Sequence format is Pearson
Sequence 1: CDK2_HUMAN 298 aa
Sequence 2: CDK1_HUMAN 297 aa
Sequence 3: CDK3_HUMAN 305 aa
Sequence 4: CDK4_HUMAN 303 aa
Sequence 5: CDK5_HUMAN 292 aa
Sequence 6: CDK6_HUMAN 326 aa
Sequence 7: CDK7_HUMAN 346 aa
Sequence 8: CDK8_HUMAN 464 aa
Sequence 9: CDK9_HUMAN 372 aa
Sequence 10: CDK10_HUMAN 360 aa
Start of Pairwise alignments
Aligning...
Sequences (2:3) Aligned. Score: 64
Sequences (4:5) Aligned. Score: 44
Sequences (3:4) Aligned. Score: 45
Sequences (2:4) Aligned. Score: 43
Sequences (1:2) Aligned. Score: 65
Sequences (3:5) Aligned. Score: 61
Sequences (4:6) Aligned. Score: 68
Sequences (2:5) Aligned. Score: 56
Sequences (1:3) Aligned. Score: 75
Sequences (3:6) Aligned. Score: 46
Sequences (4:7) Aligned. Score: 36
Sequences (2:6) Aligned. Score: 46
Sequences (1:4) Aligned. Score: 44
Sequences (3:7) Aligned. Score: 44
Sequences (4:8) Aligned. Score: 36
Sequences (2:7) Aligned. Score: 42
Sequences (1:5) Aligned. Score: 59
Sequences (4:9) Aligned. Score: 34
Sequences (1:6) Aligned. Score: 48
Sequences (3:8) Aligned. Score: 39
Sequences (2:8) Aligned. Score: 38
Sequences (4:10) Aligned. Score: 40
Sequences (1:7) Aligned. Score: 44
Sequences (3:9) Aligned. Score: 39
Sequences (2:9) Aligned. Score: 40
Sequences (5:6) Aligned. Score: 46
Sequences (3:10) Aligned. Score: 42
Sequences (1:8) Aligned. Score: 37
Sequences (2:10) Aligned. Score: 40
Sequences (5:7) Aligned. Score: 45
Sequences (6:7) Aligned. Score: 33
Sequences (1:9) Aligned. Score: 40
Sequences (7:8) Aligned. Score: 34
Sequences (5:8) Aligned. Score: 36
Sequences (1:10) Aligned. Score: 43
Sequences (6:8) Aligned. Score: 30
Sequences (7:9) Aligned. Score: 35
Sequences (5:9) Aligned. Score: 41
Sequences (6:9) Aligned. Score: 33
Sequences (8:9) Aligned. Score: 29
Sequences (5:10) Aligned. Score: 43
Sequences (7:10) Aligned. Score: 36
Sequences (6:10) Aligned. Score: 35
Sequences (9:10) Aligned. Score: 34
Sequences (8:10) Aligned. Score: 32
Guide tree file created: [/net/nfs0/vol1/production/w3nobody/tmp/939305.808162-166018.dnd]
Start of Multiple Alignment
There are 9 groups
Aligning...
Group 1: Sequences: 2 Score:5763
Group 2: Sequences: 3 Score:5387
Group 3: Sequences: 4 Score:5055
Group 4: Sequences: 2 Score:5575
Group 5: Sequences: 6 Score:4388
Group 6: Sequences: 7 Score:4502
Group 7: Sequences: 8 Score:4454
Group 8: Sequences: 9 Score:4565
Group 9: Sequences: 10 Score:3534
Alignment Score 34354
CLUSTAL-Alignment file created [/net/nfs0/vol1/production/w3nobody/tmp/939305.808162-166018.aln]
Your Multiple Sequence Alignment:
939305.808162-166018.aln
CLUSTAL W (1.81) multiple sequence alignment
CDK2_HUMAN -----------------------------------MENFQKVEKIGEGTYGVVYKARNKL 25
CDK3_HUMAN -----------------------------------MDMFQKVEKIGEGTYGVVYKAKNRE 25
CDK1_HUMAN -----------------------------------MEDYTKIEKIGEGTYGVVYKGRHKT 25
CDK5_HUMAN -----------------------------------MQKYEKLEKIGEGTYGTVFKAKNRE 25
CDK4_HUMAN ---------------------------------MATSRYEPVAEIGVGAYGTVYKARDPH 27
CDK6_HUMAN --------------------------MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLK 34
CDK10_HUMAN MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQ 60
CDK9_HUMAN --------------------MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRK 40
CDK7_HUMAN ---------------------------MALDVKSRAKRYEKLDFLGEGQFATVYKARDKN 33
CDK8_HUMAN -----------------MDYDFKVKLSSERERVEDLFEYEG-CKVGRGTYGHVYKAKRKD 42
: :* * :. *::.:
CDK2_HUMAN TG--EVVALKKIRLDTET---EGVPSTAIREISLLKELN---HPNIVKLLDVIHT----- 72
CDK3_HUMAN TG--QLVALKKIRLDLEM---EGVPSTAIREISLLKELK---HPNIVRLLDVVHN----- 72
CDK1_HUMAN TG--QVVAMKKIRLESEE---EGVPSTAIREISLLKELR---HPNIVSLQDVLMQ----- 72
CDK5_HUMAN TH--EIVALKRVRLDDDD---EGVPSSALREICLLKELK---HKNIVRLHDVLHS----- 72
CDK4_HUMAN SG--HFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRT-- 83
CDK6_HUMAN NGG-RFVALKRVRVQTGE---EGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRT-- 88
CDK10_HUMAN TD--EIVALKKVRMDKEK---DGIPISSLREITLLLRLR---HPNIVELKEVVVG----- 107
CDK9_HUMAN TG--QKVALKKVLMENEK---EGFPITALREIKILQLLK---HENVVNLIEICRTKASPY 92
CDK7_HUMAN TN--QIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS---HPNIIGLLDAFGH----- 83
CDK8_HUMAN GKDDKDYALKQIEG-------TGISMSACREIALLRELK---HPNVISLQKVFLS----- 87
. *:* : *. :: **: :* * * *:: * .
CDK2_HUMAN ---ENKLYLVFEFLHQDLKKFMDASA-------LTGIPLPLIKSYLFQLLQGLAFCHSHR 122
CDK3_HUMAN ---ERKLYLVFEFLSQDLKKYMDSTP-------GSELPLHLIKSYLFQLLQGVSFCHSHR 122
CDK1_HUMAN ---DSRLYLIFEFLSMDLKKYLDSIPP------GQYMDSSLVKSYLYQILQGIVFCHSRR 123
CDK5_HUMAN ---DKKLTLVFEFCDQDLKKYFDSCN--------GDLDPEIVKSFLFQLLKGLGFCHSRN 121
CDK4_HUMAN -DREIKVTLVFEHVDQDLRTYLDKAP-------PPGLPAETIKDLMRQFLRGLDFLHANC 135
CDK6_HUMAN -DRETKLTLVFEHVDQDLTTYLDKVP-------EPGVPTETIKDMMFQLLRGLDFLHSHR 140
CDK10_HUMAN -NHLESIFLVMGYCEQDLASLLENMP--------TPFSEAQVKCIVLQVLRGLQYLHRNF 158
CDK9_HUMAN NRCKGSIYLVFDFCEHDLAGLLSNVL--------VKFTLSEIKRVMQMLLNGLYYIHRNK 144
CDK7_HUMAN ---KSNISLVFDFMETDLEVIIKDNS--------LVLTPSHIKAYMLMTLQGLEYLHQHW 132
CDK8_HUMAN -HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANW 146
: *:: . ** :. . :* : * *: : * .
CDK2_HUMAN VLHRDLKPQNLLIN----TEGAIKLADFGLARAFGVPVR----TYTHEVVTLWYRAPEIL 174
CDK3_HUMAN VIHRDLKPQNLLIN----ELGAIKLADFGLARAFGVPLR----TYTHEVVTLWYRAPEIL 174
CDK1_HUMAN VLHRDLKPQNLLID----DKGTIKLADFGLARAFGIPIR----VYTHEVVTLWYRSPEVL 175
CDK5_HUMAN VLHRDLKPQNLLIN----RNGELKLADFGLARAFGIPVR----CYSAEVVTLWYRPPDVL 173
CDK4_HUMAN IVHRDLKPENILVT----SGGTVKLADFGLARIYSYQM-----ALTPVVVTLWYRAPEVL 186
CDK6_HUMAN VVHRDLKPQNILVT----SSGQIKLADFGLARIYSFQM-----ALTSVVVTLWYRAPEVL 191
CDK10_HUMAN IIHRDLKVSNLLMT----DKGCVKTADFGLARAYGVPVK----PMTPKVVTLWYRAPELL 210
CDK9_HUMAN ILHRDMKAANVLIT----RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200
CDK7_HUMAN ILHRDLKPNNLLLD----ENGVLKLADFGLAKSFGSPNR----AYTHQVVTRWYRAPELL 184
CDK8_HUMAN VLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKP-LADLDPVVVTFWYRAPELL 205
::***:* *:*: * :* **:*:*: :. *** ***.*::*
CDK2_HUMAN LGCKYYSTAVDIWSLGCIFAEMVTR-RALFPGDSE---------IDQLFRIFRTLGTPDE 224
CDK3_HUMAN LGSKFYTTAVDIWSIGCIFAEMVTR-KALFPGDSE---------IDQLFRIFRMLGTPSE 224
CDK1_HUMAN LGSARYSTPVDIWSIGTIFAELATK-KPLFHGDSE---------IDQLFRIFRALGTPNN 225
CDK5_HUMAN FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDV---------DDQLKRIFRLLGTPTE 224
CDK4_HUMAN LQST-YATPVDMWSVGCIFAEMFRR-KPLFCGNSE---------ADQLGKIFDLIGLPPE 235
CDK6_HUMAN LQSS-YATPVDLWSVGCIFAEMFRR-KPLFRGSSD---------VDQLGKILDVIGLPGE 240
CDK10_HUMAN LGTTTQTTSIDMWAVGCILAELLAH-RPLLPGTSE---------IHQIDLIVQLLGTPSE 260
CDK9_HUMAN LGERDYGPPIDLWGAGCIMAEMWTR-SPIMQGNTE---------QHQLALISQLCGSITP 250
CDK7_HUMAN FGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSD---------LDQLTRIFETLGTPTE 234
CDK8_HUMAN LGARHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPAD 264
: :*:*. * *:**: .:: .*: * *
CDK2_HUMAN VVWPGVTSMPDYKPSFPKWARQ-DFSKVVPPLDED--------GRSLLSQMLHYDPNKRI 275
CDK3_HUMAN DTWPGVTQLPDYKGSFPKWTRK-GLEEIVPNLEPE--------GRDLLMQLLQYDPSQRI 275
CDK1_HUMAN EVWPEVESLQDYKNTFPKWKPG-SLASHVKNLDEN--------GLDLLSKMLIYDPAKRI 276
CDK5_HUMAN EQWPSMTKLPDYKP-YPMYPATTSLVNVVPKLNAT--------GRDLLQNLLKCNPVQRI 275
CDK4_HUMAN DDWPRDVSLP--RGAFPPRGPR-PVQSVVPEMEES--------GAQLLLEMLTFNPHKRI 284
CDK6_HUMAN EDWPRDVALP--RQAFHSKSAQ-PIEKFVTDIDEL--------GKDLLLKCLTFNPAKRI 289
CDK10_HUMAN NIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEA--------GLRLLHFLFMYDPKKRA 312
CDK9_HUMAN EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP------YALDLIDKLLVLDPAQRI 304
CDK7_HUMAN EQWPDMCSLP--DYVTFKSFPGIPLHHIFSAAGDD--------LLDLIQGLFLFNPCARI 284
CDK8_HUMAN KDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRI 324
* . *: : :* *
CDK2_HUMAN SAKAALAHPFFQDVTKPVPHLRL------------------------------------- 298
CDK3_HUMAN TAKTALAHPYFSSP-EPSPAARQY----------VLQRFRH------------------- 305
CDK1_HUMAN SGKMALNHPYFNDLDNQIKKM--------------------------------------- 297
CDK5_HUMAN SAEEALQHPYFSDFCPP------------------------------------------- 292
CDK4_HUMAN SAFRALQHSYLHKDEGNPE----------------------------------------- 303
CDK6_HUMAN SAYSALSHPYFQDLERCKENLDSH----------LPPSQNTSELNTA------------- 326
CDK10_HUMAN TAGDCLESSYFKEKPLPCEPELMP----------TFPHHRNKRAAPATSEGQSKRCKP-- 360
CDK9_HUMAN DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTN 364
CDK7_HUMAN TATQALKMKYFSNRPGPTPGCQLPRP--------NCPVETLKEQSNPALAIKRKRTEALE 336
CDK8_HUMAN TSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNG 384
. .: :: .
CDK2_HUMAN ------------------------------------------------------------
CDK3_HUMAN ------------------------------------------------------------
CDK1_HUMAN ------------------------------------------------------------
CDK5_HUMAN ------------------------------------------------------------
CDK4_HUMAN ------------------------------------------------------------
CDK6_HUMAN ------------------------------------------------------------
CDK10_HUMAN ------------------------------------------------------------
CDK9_HUMAN QTEFERVF---------------------------------------------------- 372
CDK7_HUMAN QGGLPKKLIF-------------------------------------------------- 346
CDK8_HUMAN TGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSS 444
CDK2_HUMAN --------------------
CDK3_HUMAN --------------------
CDK1_HUMAN --------------------
CDK5_HUMAN --------------------
CDK4_HUMAN --------------------
CDK6_HUMAN --------------------
CDK10_HUMAN --------------------
CDK9_HUMAN --------------------
CDK7_HUMAN --------------------
CDK8_HUMAN MGYSATSQQPPQYSHQTHRY 464
Your guide tree:
939305.808162-166018.dnd
(
(
(
(
(
CDK2_HUMAN:0.12481,
CDK3_HUMAN:0.12351)
:0.04142,
CDK1_HUMAN:0.18291)
:0.03693,
CDK5_HUMAN:0.20407)
:0.03374,
(
CDK4_HUMAN:0.15061,
CDK6_HUMAN:0.15962)
:0.14838)
:0.01186,
(
(
CDK7_HUMAN:0.30313,
CDK8_HUMAN:0.35294)
:0.00818,
CDK9_HUMAN:0.33684)
:0.00406,
CDK10_HUMAN:0.31276);