ClustalW. Múltiple séquense aligment

Alpha fetoprotein

C : conserved cysteine

X : conserved pattern

X : domain

 

AFP_GORILLA         ------MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQF 54

AFP_HUMAN           ------MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQF 54

AFP_CHIMPANZEE      ------MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEINLTDLATIFFAQF 54

AFP_HORSE           ------MKWVVSILLIFLLNSTESRTMHSNAYGIASALDSFQCSPEMNLVDLATIFFAQF 54

AFP_MOUSE           ------MKWITPASLILLLHFAASKALHENEFGIASTLDSSQCVTEKNVLSIATITFTQF 54

AFP_RAT             MKQPATMKWSASISFLLLLNFAEPRVLHTNEFGIESTLDSSQCPTEKNMFNVATIVVAQF 60

                          ***  .  :::**: : .:.:* * :** * *** ** .* .: .:*** .:**

 

AFP_GORILLA         VQEATYKEVSKMVKDALTAIEKPTGDEQSAGCLENQLPAFLEELCHEKEILEKYGLSDCC 114

AFP_HUMAN           VQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCC 114

AFP_CHIMPANZEE      VQEATYKEVSKMVKDALTAIEKPTGDEQSAGCLENQLPAFLEELCREKEILEKYGHSDCC 114

AFP_HORSE           VQEATYKEVSKMVKDVLTVTEKSTGSEQPTGCSENRLSAFLEEICHEEEIPEKYGLSGCC 114

AFP_MOUSE           VPEATEEEVNKMTSDVLAAMKKNSGD----GCLESQLSVFLDEICHETELSNKYGLSGCC 110

AFP_RAT             VQDATKAEVNKMSSDALAAMKENTGD----GCLENQLSVFLDEICHETELSNKYGFSGCC 116

                    * :**  **.** .*.*:. :: :*.    ** *.:*..**:*:*:* *: :*** *.**

 

AFP_GORILLA         SQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLY 174

AFP_HUMAN           SQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLY 174

AFP_CHIMPANZEE      SQSEEGRHNCFLAHKKPTPASIPFFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLY 174

AFP_HORSE           SQNEEERHNCLLARKKDSPASIPPFQVPEPVTSCKAYEENREMFLNRYLYEIARRHPFLY 174

AFP_MOUSE           SQSGVERHQCLLARKKTAPASVPPFQFPEPAESCKAHEENRAVFMNRFIYEVSRRNPFMY 170

AFP_RAT             NQSGVERHQCLLARKKTAPDSVPPFHFPETAESCPAYEENRAMSINTFIYDVSKRNPFLY 176

                    .*.   **:*:**:** :* *:* *:.**.. ** *:**:*   :* ::*::::*:**:*

 

AFP_GORILLA         APTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRT 234

AFP_HUMAN           APTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRT 234

AFP_CHIMPANZEE      APTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRT 234

AFP_HORSE           SSTALYLASHYDKIISACCKSENAVECFQSKAATITKELRETSLLNQHVCAVIRNFGPRT 234

AFP_MOUSE           APAILSLAAQYDKVVLACCKADNKEECFQTKRASIAKELREGSMLNEHVCSVIRKFGSRN 230

AFP_RAT             APTILYLAAQYDKAVPACCKADNMEECFQTKRASMAKELREGSMLNEHVCAVIRKFGSRN 236

                    :.: *  *::*** : :***::*  ****:* *:::***** *:**:*.*:*:::**.*.

 

AFP_GORILLA         FQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDT 294

AFP_HUMAN           FQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDT 294

AFP_CHIMPANZEE      FQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDT 294

AFP_HORSE           LQAITVTTLSQRYSKANFTEIQKLVLDVAHAHEECCRGNVEECVQDGEKLISYVCSQEDI 294

AFP_MOUSE           LQATTIIKLSQKLTEANFTEIQKLALDVAHIHEECCQGNSLECLQDGEKVMTYICSQQNI 290

AFP_RAT             LQAVLIIKLSQKFPKANITEIRKLALDVAHIHEQCCHGNAMECLQDGESVMTHMCSQQEI 296

                    :**  : .***: .:.*:***:**.***** **.**:*:  :*:****.:::::***::

 

AFP_GORILLA         LSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASF 354

AFP_HUMAN           LSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASF 354

AFP_CHIMPANZEE      LSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASF 354

AFP_HORSE           LSSSIVECCKLPTVELAQCIIHAENDDKPEGLSPNLNRLLGERDFNQFSSKEKDLFMARF 354

AFP_MOUSE           LSSKIAECCKLPMIQLGFCIIHAENGVKPEGLSLNPSQFLGDRNFAQFSSEEKIMFMASF 350

AFP_RAT             LSSKTAECCKLPTIELGYCIIHAENGDKPEGLTLNPSEFLGDRNFAQFSSEEKLLFMASF 356

                    **.. .*****. :: . *******. *****: * ..:**:*:* **** ** :*:* *

 

AFP_GORILLA         VHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKR 414

AFP_HUMAN           VHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKR 414

AFP_CHIMPANZEE      VHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKR 414

AFP_HORSE           TYEYSRRHTKLAVPVILRVAKGYQEFLEKCSQSENPLECQDKGEEELQKYIQEGQALAKR 414

AFP_MOUSE           LHEYSRTHPNLPVSVILRIAKTYQEILEKCSQSGNLPGCQDNLEEELQKHIEESQALSKQ 410

AFP_RAT             LHEYSRNHPNLPVSVILKTAKSYQEILEKCSQSETPSKCQDNMEEELQKHIQESQALAKQ 416

                     :**** *.:*.*.***: ** ***:**** *: .   ***: ******:*:*.***:*:

 

AFP_GORILLA         SCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGE 474

AFP_HUMAN           SCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGE 474

AFP_CHIMPANZEE      SCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGE 474

AFP_HORSE           SCGLFQKLGDYYLQNAFLVAYTKKAPQLTPPELIALTRKMATAAATCCQLSEDKQLACGE 474

AFP_MOUSE           SCALYQTLGDYKLQNLFLIGYTRKAPQLTSAELIDLTGKMVSIASTCCQLSEEKWSGCGE 470

AFP_RAT             SCNLYQKLGPYYLQNLFLIGYTRKAPQLTSAELIDLTGKMVSIASTCCQLSEEKRSACGE 476

                    ** *:*.** * *** **:.**:******..**: :* **.: *:*******:*  .***

 

AFP_GORILLA         GAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFH 534

AFP_HUMAN           GAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFH 534

AFP_CHIMPANZEE      GAADIIIGHLCIRHETTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFH 534

AFP_HORSE           QVAGLIIGQLCIRHEESPINPGVGQCCTSSYANRRPCFSSLVVDETYVPPPFSDDKFIFH 534

AFP_MOUSE           GMADIFIGHLCIRNEASPVNSGISHCCNSSYSNRRLCITSFLRDETYAPPPFSEDKFIFH 530

AFP_RAT             GLADIYIGHLCLRHEANPVNSGINHCCSSSYSNRRLCITSFLRDETYVPPPFSEDKFIFH 536

                      *.: **:**:*:* .*:*.*:.:**.***:*** *::*:: ****.**.**:******

 

AFP_GORILLA         KDLCQAQGVALQTMKQEFLINLVKQKPQITEEQLETVIADFSGLLEKCCQGQEQEVCFAE 594

AFP_HUMAN           KDLCQAQGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAE 594

AFP_CHIMPANZEE      KDLCQAQGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAE 594

AFP_HORSE           KDLCQAQGVALQTMKQQFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQGQEVCFSE 594

AFP_MOUSE           KDLCQAQGKALQTMKQELLINLVKQKPELTEEQLAAVTADFSGLLEKCCKAQDQEVCFTE 590

AFP_RAT             KDLCQAQGRALQTMKQELLINLVKQKPEMTEEQHAAVTADFSGLLEKCCKDQDQEACFAK 596

                    ******** *******::*********::****  :* ***********: * **.**::

 

AFP_GORILLA         EGQKLISKTRTALGV 609

AFP_HUMAN           EGQKLISKTRAALGV 609

AFP_CHIMPANZEE      EGQKLISKTRAALGV 609

AFP_HORSE           EGPQLISKTRAALGV 609

AFP_MOUSE           EGPKLISKTRDALGV 605

AFP_RAT             EGPKLISKTREALGV 611

                    ** :****** ****