CLUSTAL W (1.81) multiple sequence alignment
Vitamin D-binding protein
 
C: conserved cysteine
X: conserved pattern
X: domain
 
 
VTDB_RAT         MKRVLVLLLALAFGHALERGRDYEKDKVCQELSTLGKDDFRSLSLILYSRKFPSSTFEQV 60
VTDB_MOUSE       ----LVLLLALAFGHALERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQV 56
VTDB_HUMAN       MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV 60
VTDB_RABBIT      MKRVLLLLLAVVCGHALERGRDYEKDKVCKELSTLGKDDFRTLSLVLYSRKFPSGTFDQV 60
                     *:****:. ************:***:*:: ***:** :***:******.*.**:**
 
VTDB_RAT         SQLVKEVVSLTEECCAEGADPNCYDTRTSELSIKSCESDAPFPVHPGTSECCTKEGLERK 120
VTDB_MOUSE       NQLVKEVVSLTEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERK 116
VTDB_HUMAN       SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK 120
VTDB_RABBIT      MKLVKEVVSLTEDCCTEDADPGCYDNRTSALSATSCESDSPFPVHPGTAECCTKEGLGRK 120
                  :********** **:*.*** ***.*** ** .****::********.******** **
 
VTDB_RAT         LCMAALSHQPQEFPAYVEPTNDEICEAFRKDPKGFADQFLFEYSSNYGQAPLPLLVGYTK 180
VTDB_MOUSE       LCMAALSHQPQEFPTYVEPTNDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTK 176
VTDB_HUMAN       LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK 180
VTDB_RABBIT      LCMAALKHPPQEFPTYVEPANDEICEAFRQDPMEFADKFLYEYSSNYGQAPLPILVSYTK 180
                 ******.* *****:****:*********:**  :*::*::***:*******.:**.***
 
VTDB_RAT         SYLSMVGSCCTSAKPTVCFLKERLQMKQLLLLTTMSNRVCSQYAAYGKEKSRMSHLIKLA 240
VTDB_MOUSE       NYLSMVGSCCTSANPTVCFVKERLQMKHLSLLTTMSNRVCSQYAAYGKEKSRLSHLIKLA 236
VTDB_HUMAN       SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA 240
VTDB_RABBIT      SYLSMVGTCCTSASPTVCFLKERLQIKHLSLLTTLSNRVCSQYAAYGKEKSRRSHLIKLA 240
                 .******:*****.*****:*****:*:* ****:************::*** *:*****
 
VTDB_RAT         QKVPTANLEDVLPLAEDLTEILSRCCKSTSEDCMARELPEHTLKICGNLSKKNSKFEECC 300
VTDB_MOUSE       QKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPEHTIKICQNLSKKNSKFEECC 296
VTDB_HUMAN       QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC 300
VTDB_RABBIT      QKAPTAALKEVLPLAEDITNILSKCCESTSEDCMAKELPEHTVKICDTLSTKNPKFEECC 300
                 **.*** *::*******:*:***:**:*:****** ******:*:* .**.**.***:**
 
VTDB_RAT         YETTPMGIFMCSYFMPTAEPLQLPAIKLPTSKDLCGQSATQAMDQYTFELSRRTQVPEVF 360
VTDB_MOUSE       QENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFELSRRTQVPEVF 356
VTDB_HUMAN       QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF 360
VTDB_RABBIT      QEKTPMDIFVCTYFMPAAQPPEPANVELPTSKDVCDSKNINVMDQYTFELSRKTHIPEVF 360
                  *.*.*.:*:*:****:*:  : . ::***.**:*.    :.**:*******:*::****
 
VTDB_RAT         LSKVLDTTLKTLRECCDTQDSVSCFSTQSPLMKRQLTSFIEKGQEMCADYSENTFTEYKK 420
VTDB_MOUSE       LSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKK 416
VTDB_HUMAN       LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK 420
VTDB_RABBIT      LSKVLEPTLKSLSECCHSADSTACLNAKGPVLKKEVSSFIDKGQELCAGYSENTFTEYKK 420
                 *****:.***:* ***.  **.:*:.::.*::*::::***:****:**.***********
 
VTDB_RAT         KLAERLRTKMPNASPEELADMVAKHSDFASKCCSINSPPRYCSSQIDAEMRDILQS 476
VTDB_MOUSE       KLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS 472
VTDB_HUMAN       KLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL-- 474
VTDB_RABBIT      KLSQQLRAKLPEATSAELAELVEKHSDFASKCCSINSPPNYCDSEIDAEIKNLPEP 476
                 **:::*::* *:::. ** .:* *:*****:******** **.*:****: :